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Sample records for actinium 225

  1. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces ∼100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 GeV protons

  2. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  3. New method for large scale production of medically applicable Actinium-225 and Radium-223

    Alpha-emitters (211At, 212Bi, 213Bi, 223Ra, 225Ac) are promising for targeted radiotherapy of cancer. Only two alpha decays near a cell membrane result in 50% death of cancer cell and only a single decay inside the cell is required for this. 225Ac may be used either directly or as a mother radionuclide in 213Bi isotope generator. Production of 225Ac is provided by three main suppliers - Institute for Transuranium Elements in Germany, Oak Ridge National Laboratory in USA and Institute of Physics and Power Engineering in Obninsk, Russia. The current worldwide production of 225Ac is approximately 1.7 Ci per year that corresponds to only 100-200 patients that could be treated annually. The common approach for 225Ac production is separation from mother 229Th or irradiation of 226Ra with protons in a cyclotron. Both the methods have some practical limitations to be applied routinely. 225Ac can be also produced by irradiation of natural thorium with medium energy protons . Cumulative cross sections of 225Ac, 227Ac, 227Th, 228Th formations have been obtained recently. Thorium targets (1-9 g) were irradiated by 114-91 MeV proton beam (1-50 μA) at INR linear accelerator. After dissolution in 8 M HNO3 + 0.004 M HF thorium was removed by double LLX by HDEHP in toluene (1:1). Ac and REE were pre-concentrated and separated from Ra and most fission products by DGA-Resin (Triskem). After washing out by 0.01 M HNO3 Ac was separated from REE by TRU Resin (Triskem) in 3 M HNO3 media. About 6 mCi 225Ac were separated in hot cell with chemical yield 85%. The method may be upscaled for production of Ci amounts of the radionuclide. The main impurity is 227Ac (0.1% at the EOB) but it does not hinder 225Ac from being used for medical 225Ac/213Bi generators. (author)

  4. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  5. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the

  6. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  7. Spectroscopic and computational investigation of actinium coordination chemistry.

    Ferrier, Maryline G; Batista, Enrique R; Berg, John M; Birnbaum, Eva R; Cross, Justin N; Engle, Jonathan W; La Pierre, Henry S; Kozimor, Stosh A; Lezama Pacheco, Juan S; Stein, Benjamin W; Stieber, S Chantal E; Wilson, Justin J

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, Ac(III) reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between Ac(III) and Am(III) in HCl solutions indicate Ac(III) coordinates more inner-sphere Cl(1-) ligands (3.2±1.1) than Am(III) (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique Ac(III) chemical behaviour. PMID:27531582

  8. Generator method of 225Ac production without a carrier for nuclear medicine

    The two-steps isotope generator scheme of 225Ac production from 229Th has been developed. The first step is used for separation of thorium, actinium, radium and daughter decay products (DDP), and removals of parent radionuclide. The second step provides additional separation of actinium from traces of radium and DDP, and conversion of actinium in the nitrate form. The chosen solutions provide optimal conditions for carry out of process. The yield of the 225Ac was 99.9% at minimal losses of parent 229Th (less than 0.1%)

  9. Extraction of actinium with di-(2-ethylhexyl)phosphoric acid from hydrochloric and nitric acid solutions

    The extraction of actinium with HDEHP from Cl- and NO3- systems has been investigated. It was found that extraction of actinium from HCl solutions is much better than from HNO3 solutions. Stability constants of actinium complexes Ac(X-)+2 with Cl- and NO3- ligands were determined. Our results show that the actinium formed less stable complexes with Cl- than with NO3- ligands. 5 refs., 3 figs., 1 tab. (author)

  10. The sorption of polonium, actinium and protactinium onto geological materials

    This paper describes a combined experimental and modeling program of generic sorption studies to increase confidence in the performance assessment for a potential high-level radioactive waste repository in Japan. The sorption of polonium, actinium and protactinium onto geological materials has been investigated. Sorption of these radioelements onto bentonite, tuff and granodiorite from equilibrated de-ionized water was studied under reducing conditions at room temperature. In addition, the sorption of actinium and protactinium was investigated at 60 C. Thermodynamic chemical modeling was carried out to aid interpretation of the results

  11. Separation of Actinium 227 from the uranium minerals

    The purpose of this work was to separate Actinium 227, whose content is 18%, from the mineral carnotite found in Gomez Chihuahua mountain range in Mexico. The mineral before processing is is pre-concentrated and passed, first through anionic exchange resins, later the eluate obtained is passed through cationic resins. The resins were 20-50 MESH QOWEX and 100-200 MESH 50 X 8-20 in some cased 200-400 MESH AG 50W-X8, 1X8 in other cases. The eluates from the ionic exchange were electrodeposited on stainless steel polished disc cathode and platinum electrode as anode; under a current ODF 10mA for 2.5 to 5 hours and of 100mA for .5 of an hour. it was possible to identify the Actinium 227 by means of its descendents, TH-227 and RA-223, through alpha spectroscopy. Due to the radiochemical purity which the electro deposits were obtained the Actinium 227 was low and was not quantitatively determined. A large majority of the members of the natural radioactive series 3 were identified and even alpha energies reported in the literature with very low percentages of non-identified emissions were observed. We conclude that a more precise study is needed concerning ionic exchange and electrodeposit to obtain an Actinium 227 of radiochemical purity. (Author)

  12. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    Fry, C; Thoennessen, M

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  13. Production of high-purity radium-223 from legacy actinium-beryllium neutron sources.

    Soderquist, Chuck Z; McNamara, Bruce K; Fisher, Darrell R

    2012-07-01

    Radium-223 is a short-lived alpha-particle-emitting radionuclide with potential applications in cancer treatment. Research to develop new radiopharmaceuticals employing (223)Ra has been hindered by poor availability due to the small quantities of parent actinium-227 available world-wide. The purpose of this study was to develop innovative and cost-effective methods to obtain high-purity (223)Ra from (227)Ac. We obtained (227)Ac from two surplus actinium-beryllium neutron generators. We retrieved the actinium/beryllium buttons from the sources and dissolved them in a sulfuric-nitric acid solution. A crude actinium solid was recovered from the solution by coprecipitation with thorium fluoride, leaving beryllium in solution. The crude actinium was purified to provide about 40 milligrams of actinium nitrate using anion exchange in methanol-water-nitric acid solution. The purified actinium was then used to generate high-purity (223)Ra. We extracted (223)Ra using anion exchange in a methanol-water-nitric acid solution. After the radium was separated, actinium and thorium were then eluted from the column and dried for interim storage. This single-pass separation produces high purity, carrier-free (223)Ra product, and does not disturb the (227)Ac/(227)Th equilibrium. A high purity, carrier-free (227)Th was also obtained from the actinium using a similar anion exchange in nitric acid. These methods enable efficient production of (223)Ra for research and new alpha-emitter radiopharmaceutical development. PMID:22697483

  14. BEH 225 Tutorials /beh225dotcom

    veena022

    2015-01-01

    BEH 225 Entire Course For more course tutorials visit www.beh225.com   BEH 225 Week 1 CheckPointResearch Methods BEH 225 Week 1 DQ 1 and DQ 2 BEH 225 Week 2 CheckPointHeredity and Hormones BEH 225 Week 2 AssignmentBrain Response of Behavior BEH 225 Week 3 CheckPointIntelligence Presentation BEH 225 Week 3 DQ 1 and DQ 2 BEH 225 Week 4 CheckPointSkinner Article BEH 225 Week 4 AssignmentProblem-Solving Simulation BEH 225 Week 5 CheckPointMotiv...

  15. Synthesis of chelating agents for actinium 225 complexation and its application in radioimmunotherapy

    Immunotherapy with radiolabeled antibodies should allow fairly specific targeting of certain cancers. However, iodine 131 may not be the best isotope for tumor therapy because of its limited specific activity, low beta-energy, relatively long half life and strong gamma emission. Another approach to improve therapeutic efficacy is the use of replacement isotopes with better physical properties. Chelator that can hold radio-metals with high stability under physiological conditions are essential to avoid excessive damage to non-target cells; Moreover, the development of new bifunctional chelating agents is essential for this purpose. Accordingly, our efforts have been directed, for several years, to the synthesis of original chelating agents likely to form stable complexes in vivo with the numerous potential candidates for such applications. Therefore, we have developed a new simple and efficient synthesis pathway of 2-(4-iso-thio-cyanate-benzyl)-1,4,7,10,13,16- hexa-aza-cyclo-hexadecane- 1,4,7,10,13,16-hexa-acetic acid, though functionalized on the cycle by a termination allowed coupling to an antibody or any other biological substance such as a hapten. (author)

  16. Radium, thorium, and actinium extraction from seawater using an improved manganese-oxide-coated fiber

    Laboratory experiments were conducted to determine the efficiency with which improved manganese-oxide-coated acrylic fibers extract radium, thorium, and actinium from seawater. Tests were made using surface seawater spiked with 227Ac, 227Th and 223Ra. For sample volumes of approximately 30 liters and flow rates up to 0.5 liters per minute, radium and actinium are removed quantitatively. Approximately 80-95% of the thorium is removed under these same conditions. (Auth.)

  17. ADJ 225 Courses Tutorial / indigohelp

    nesa

    2015-01-01

    ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ADJ 225 Assignment Risk Factor Handout ADJ 225 CheckPoint Community Agency Goals ADJ 225 CheckPoint 1 Juvenile Court Characteristics ADJ 2...

  18. ENG 225 ASH Course Tutorial / eng225dotcom

    anil27

    2015-01-01

    ENG 225 Entire Course (Ash) For more course tutorials visit www.eng225.com   ENG 225 Week 1 DQ 1 An Evolving Industry ENG 225 Week 1 DQ 2 Narrative and Storytelling ENG 225 Week 1 Quiz ENG 225 Week 2 DQ 1 Actors and Acting ENG 225 Week 2 DQ 2 Tools of Cinematography ENG 225 Week 2 Assignment Elements of Design ENG 225 Week 2 Quiz ENG 225 Week 3 DQ 1 Frame by Frame ENG 225 Week 3 DQ 2 Music and Soundscapes ENG 225 Week 3 Assignment Final Film Cri...

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    Sandywilliam1

    2015-01-01

    ENG 225 Entire Course (Ash) For more course tutorials visit www.eng225.com   ENG 225 Week 1 DQ 1 An Evolving Industry ENG 225 Week 1 DQ 2 Narrative and Storytelling ENG 225 Week 1 Quiz ENG 225 Week 2 DQ 1 Actors and Acting ENG 225 Week 2 DQ 2 Tools of Cinematography ENG 225 Week 2 Assignment Elements of Design ENG 225 Week 2 Quiz ENG 225 Week 3 DQ 1 Frame by Frame ENG 225 Week 3 DQ 2 Music and Soundscapes ENG 225 Week 3 Assignment Final Film Cri...

  20. ADJ 225 Course Tutorial / tutorialrank

    welcome1365

    2015-01-01

    ADJ 225 Entire Course For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 1 Times, Rating: A+     ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ...

  1. Neutron-Induced Fission of Actinium-227, Protactinium-231 and Neptunium-237: Mass Distribution

    Results of radiochemical studies on the mass distribution in the neutron-induced fission of actinium-227, protactinium-231 and neptunium-237 have been presented. This work has been carried out as part of a programme to determine the mass distribution in the fission of heavy elements as a function of Z and A. All irradiations have been carried out in the core of the swimming-pool type reactor APSARA with cadmium shielding wherever necessary. Relative yields of several fission product nuclides have been obtained by a method involving a comparison of the fission product activities from the respective targets with those formed from uranium-235 simultaneously irradiated. Thermal-neutron fission yields of uranium-235 have been assumed. These results indicate a predominantly asymmetric mass distribution in all the three cases, and also a distinct though small symmetric peak in the case of actinium-227. (author)

  2. A new method for the determination of low-level actinium-227 in geological samples

    We developed a new method for the determination of 227Ac in geological samples. The method uses extraction chromatographic techniques and alpha-spectrometry and is applicable for a range of natural matrices. Here we report on the procedure and results of the analysis of water (fresh and seawater) and rock samples. Water samples were acidified and rock samples underwent total dissolution via acid leaching. A DGA (N,N,N',N'-tetra-n-octyldiglycolamide) extraction chromatographic column was used for the separation of actinium. The actinium fraction was prepared for alpha spectrometric measurement via cerium fluoride micro-precipitation. Recoveries of actinium in water samples were 80 ± 8 % (number of analyses n = 14) and in rock samples 70 ± 12 % (n = 30). The minimum detectable activities (MDA) were 0.017-0.5 Bq kg-1 for both matrices. Rock sample 227Ac activities ranged from 0.17 to 8.3 Bq kg-1 and water sample activities ranged from below MDA values to 14 Bq kg-1of 227Ac. From the analysis of several standard rock and water samples with the method we found very good agreement between our results and certified values. (author)

  3. ADJ 225 Courses/snaptutorial

    charles

    2015-01-01

    ­For more classes visits www.snaptutorial.com                 ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ADJ ...

  4. BEH 225 Course tutorial/ indigohelp

    AcSCCSA

    2015-01-01

    For more classes visit www.indigohelp.com   BEH 225 Week 1 CheckPointResearch Methods BEH 225 Week 1 DQ 1 and DQ 2 BEH 225 Week 2 CheckPoint Heredity and Hormones BEH 225 Week 2 Assignment Brain Response of Behavior BEH 225 Week 3 CheckPoint Intelligence Presentation BEH 225 Week 3 DQ 1 and DQ 2 BEH 225 Week 4 CheckPoint Skinner Article BEH 225 Week 4 AssignmentProblem-Solving Simulation BEH 225 Week 5 CheckPoint Motivating Employees BEH 22...

  5. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    Momeni, M.H.

    1981-09-01

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore.

  6. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore

  7. ADJ 225 UOP COURSE Tutorial/UOPHELP

    mangush

    2015-01-01

    For more course tutorials visit www.uophelp.com       ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ADJ 225 Assignment Risk Factor Handout ADJ 225 CheckPoint...

  8. In-source laser spectroscopy developments at TRILIS—towards spectroscopy on actinium and scandium

    Resonance Ionization Laser Ion Sources (RILIS) have become a versatile tool for production and study of exotic nuclides at Isotope Separator On-Line (ISOL) facilities such as ISAC at TRIUMF. The recent development and addition of a grating tuned spectroscopy laser to the TRIUMF RILIS solid state laser system allows for wide range spectral scans to investigate atomic structures on short lived isotopes, e.g., those from the element actinium, produced in uranium targets at ISAC. In addition, development of new and improved laser ionization schemes for rare isotope production at ISAC is ongoing. Here spectroscopic studies on bound states, Rydberg states and autoionizing (AI) resonances on scandium using the existing off-line capabilities are reported. These results allowed to identify a suitable ionization scheme for scandium via excitation into an autoionizing state at 58,104 cm − 1 which has subsequently been used for ionization of on-line produced exotic scandium isotopes.

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    dfvgbnm,m

    2015-01-01

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    NARESH 1

    2015-01-01

    For more course tutorials visit www.tutorialoutlet.com     ENG 225 Week 1 DQ 1 An Evolving Industry ENG 225 Week 1 DQ 2 Narrative and Storytelling ENG 225 Week 1 Quiz ENG 225 Week 2 DQ 1 Actors and Acting ENG 225 Week 2 DQ 2 Tools of Cinematography ENG 225 Week 2 Assignment Elements of Design ENG 225 Week 2 Quiz ENG 225 Week 3 DQ 1 Frame by Frame ENG 225 Week 3 DQ 2 Music and Soundscapes ENG 225 Week 3 Assignment Final Film Critique Draft ...

  11. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Raeder, S.; Bastin, B.; Block, M.; Creemers, P.; Delahaye, P.; Ferrer, R.; Fléchard, X.; Franchoo, S.; Ghys, L.; Gaffney, L. P.; Granados, C.; Heinke, R.; Hijazi, L.; Huyse, M.; Kron, T.; Kudryavtsev, Yu.; Laatiaoui, M.; Lecesne, N.; Luton, F.; Moore, I. D.; Martinez, Y.; Mogilevskiy, E.; Naubereit, P.; Piot, J.; Rothe, S.; Savajols, H.; Sels, S.; Sonnenschein, V.; Traykov, E.; Van Beveren, C.; Van den Bergh, P.; Van Duppen, P.; Wendt, K.; Zadvornaya, A.

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  12. ADJ 225 UOP Course Tutorial / Tutorialrank

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    2015-01-01

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    2015-01-01

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    sando

    2015-01-01

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    2010-04-01

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  18. 21 CFR 225.10 - Personnel.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Personnel. 225.10 Section 225.10 Food and Drugs... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS General Provisions § 225.10 Personnel. (a) Qualified personnel and adequate personnel training and supervision are essential for the proper...

  19. 49 CFR 238.225 - Electrical system.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Electrical system. 238.225 Section 238.225... Equipment § 238.225 Electrical system. All passenger equipment shall comply with the following: (a... derated for grouping and for operating temperature. (b) Main battery system. (1) The main...

  20. 12 CFR 225.65 - Appraiser independence.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Appraiser independence. 225.65 Section 225.65 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM... Federally Related Transactions § 225.65 Appraiser independence. (a) Staff appraisers. If an appraisal...

  1. 40 CFR 46.225 - Equipment.

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Equipment. 46.225 Section 46.225... After the Fellowship § 46.225 Equipment. (a) If EPA authorizes you to purchase equipment (see § 46.140(b)) and the equipment retains a fair market value of more than $5,000, you must request...

  2. 21 CFR 225.30 - Equipment.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Equipment. 225.30 Section 225.30 Food and Drugs... Equipment § 225.30 Equipment. (a) Equipment which is designed to perform its intended function and is properly installed and used is essential to the manufacture of medicated feeds. Such equipment...

  3. 21 CFR 225.130 - Equipment.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Equipment. 225.130 Section 225.130 Food and Drugs... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Facilities and Equipment § 225.130 Equipment. Equipment shall be capable of producing a medicated feed of intended potency and purity, and shall...

  4. 21 CFR 225.42 - Components.

    2010-04-01

    ... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Product Quality Control § 225.42 Components. (a) A... inventory control for all such drugs to aid in assuring their identity, strength, quality, and purity when... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Components. 225.42 Section 225.42 Food and...

  5. 12 CFR 225.3 - Administration.

    2010-01-01

    ... Regarding Delegation of Authority (12 CFR part 265) and the Board's Rules of Procedure (12 CFR part 262). (b... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Administration. 225.3 Section 225.3 Banks and... COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations General Provisions § 225.3...

  6. ADJ 225 UOP Course Tutorial/TutorialRank

    apj

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 1 Times, Rating: A+   ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ADJ 225 Assignment Risk Factor Han...

  7. Octupole correlations in 225Th

    The nuclear structure of 225Th has been studied using the reaction 226Ra(α, 5n)225Th at a beam energy of 50 MeV. In-beam γγ, e-e-, e-n and e-γ coincidences have been measured, along with γ-ray and electron intensities, and these have been used to establish a decay scheme up to spin 39/2 ℎ and excitation energy 2494 keV. Parity doublets have been observed, forming two 'quasi-molecular bands', along with enhanced E1 transitions linking states of opposite parity. γ-branching ratios have been measured and an average value of vertical strokeD0/Q0vertical stroke=(0.51±0.06)x10-3 fm-1 has been deduced. The results are compared with calculations incorporating odd multipole degrees of freedom in the description of the nuclear shape. (orig.)

  8. DNA double strand breaks as predictor of efficacy of the alpha-particle emitter Ac-225 and the electron emitter Lu-177 for somatostatin receptor targeted radiotherapy.

    Franziska Graf

    Full Text Available RATIONALE: Key biologic effects of the alpha-particle emitter Actinium-225 in comparison to the beta-particle emitter Lutetium-177 labeled somatostatin-analogue DOTATOC in vitro and in vivo were studied to evaluate the significance of γH2AX-foci formation. METHODS: To determine the relative biological effectiveness (RBE between the two isotopes (as - biological consequence of different ionisation-densities along a particle-track, somatostatin expressing AR42J cells were incubated with Ac-225-DOTATOC and Lu-177-DOTATOC up to 48 h and viability was analyzed using the MTT assay. DNA double strand breaks (DSB were quantified by immunofluorescence staining of γH2AX-foci. Cell cycle was analyzed by flow cytometry. In vivo uptake of both radiolabeled somatostatin-analogues into subcutaneously growing AR42J tumors and the number of cells displaying γH2AX-foci were measured. Therapeutic efficacy was assayed by monitoring tumor growth after treatment with activities estimated from in vitro cytotoxicity. RESULTS: Ac-225-DOTATOC resulted in ED50 values of 14 kBq/ml after 48 h, whereas Lu-177-DOTATOC displayed ED50 values of 10 MBq/ml. The number of DSB grew with increasing concentration of Ac-225-DOTATOC and similarly with Lu-177-DOTATOC when applying a factor of 700-fold higher activity compared to Ac-225. Already 24 h after incubation with 2.5-10 kBq/ml, Ac-225-DOTATOC cell-cycle studies showed up to a 60% increase in the percentage of tumor cells in G2/M phase. After 72 h an apoptotic subG1 peak was also detectable. Tumor uptake for both radio peptides at 48 h was identical (7.5%ID/g, though the overall number of cells with γH2AX-foci was higher in tumors treated with 48 kBq Ac-225-DOTATOC compared to tumors treated with 30 MBq Lu-177-DOTATOC (35% vs. 21%. Tumors with a volume of 0.34 ml reached delayed exponential tumor growth after 25 days (44 kBq Ac-225-DOTATOC and after 21 days (34 MBq Lu-177-DOTATOC. CONCLUSION: γH2AX-foci formation, triggered

  9. Groundwater seepage from the Ranger uranium mine tailings dam: radioisotopes of radium, thorium and actinium. Supervising Scientist report 106

    Monitoring of bores near the Ranger uranium mine tailings dam has revealed deterioration in water quality in several bores since 1983. In a group of bores to the north of the dam, increases have been observed of up to 500 times for sulphate concentrations and of up to 5 times for 226Ra concentrations. Results are presented here of measurements of members of the uranium, thorium and actinium decay series in borewater samples collected between 1985 and 1993. In particular, measurements of all four naturally-occurring radium isotopes have been used in an investigation of the mechanism of radium concentration changes. For the most seepage-affected bores the major findings of the study include: 228Ra/226Ra 223Ra /226Ra and 224Ra/228Ra ratios all increased over the course of the study; barium concentrations show high seasonal variability, being lower in November than May, but strontium concentrations show a steady increase with time. Calculations show that the groundwater is probably saturated with respect to barite but not with respect to celestite or anglesite; sulphide concentrations are low in comparison with sulphate, and are higher in November than in May; and 227Ac concentrations have increased with time, but do not account for the high 223Ra/226Ra ratios. It is concluded on the basis of these observations that increases in Ra isotope concentrations observed in a number of seepage-affected bores arise from increases in salinity leading to desorption of radium from adsorption sites in the vicinity of the bore rather by direct transport of radium from the tailings. Increased salinity is also causing the observed increases in 227Ac and strontium concentrations, while formation of a barite solid phase in the groundwater is causing the removal of some radium from solution. This is the cause of the increasing radium isotope ratios noted above

  10. 48 CFR 225.503 - Group offers.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Group offers. 225.503... OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Evaluating Foreign Offers-Supply Contracts 225.503 Group offers. Evaluate group offers in accordance with FAR 25.503, but apply the...

  11. 48 CFR 225.104 - Nonavailable articles.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Nonavailable articles. 225.104 Section 225.104 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Nonavailable articles. (a) DoD has determined that the following articles also are nonavailable in...

  12. 24 CFR 990.225 - Transition determination.

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Transition determination. 990.225 Section 990.225 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT THE PUBLIC HOUSING OPERATING...

  13. 21 CFR 225.58 - Laboratory controls.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Laboratory controls. 225.58 Section 225.58 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Product Quality Control §...

  14. 12 CFR 225.177 - Definitions.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Definitions. 225.177 Section 225.177 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Merchant Banking Investments §...

  15. 25 CFR 225.2 - Information collection.

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Information collection. 225.2 Section 225.2 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS OIL AND GAS, GEOTHERMAL, AND... require review under the Paperwork Reduction Act (44 U.S.C. 3501 et seq.)....

  16. 31 CFR 800.225 - United States.

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false United States. 800.225 Section 800... TAKEOVERS BY FOREIGN PERSONS Definitions § 800.225 United States. The term United States or U.S. means the United States of America, the States of the United States, the District of Columbia, and any...

  17. 40 CFR 86.225-94 - [Reserved

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false 86.225-94 Section 86.225-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty...

  18. Dicty_cDB: SSI225 [Dicty_cDB

    Full Text Available SS (Link to library) SSI225 (Link to dictyBase) - - - Contig-U12571-1 SSI225E (Link... to Original site) - - - - - - SSI225E 293 Show SSI225 Library SS (Link to library) Clone ID SSI225 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSI2-B/SSI225Q.Seq.d/ Representative seq. ID SSI22...5E (Link to Original site) Representative DNA sequence >SSI225 (SSI225Q) /CSM/SS/SSI2-B/SSI225Q.Seq.d/ CTTTA...irkkk*e Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SSI225 (SSI

  19. Dicty_cDB: CHR225 [Dicty_cDB

    Full Text Available CH (Link to library) CHR225 (Link to dictyBase) - - - Contig-U11316-1 - (Link to Original site) - - CHR...225Z 621 - - - - Show CHR225 Library CH (Link to library) Clone ID CHR225 (Link to dicty...iol.tsukuba.ac.jp/CSM/CH/CHR2-B/CHR225Q.Seq.d/ Representative seq. ID - (Link to ...Original site) Representative DNA sequence >CHR225 (CHR225Q) /CSM/CH/CHR2-B/CHR225Q.Seq.d/ XXXXXXXXXXTTAGCTC... CSM-cDNA Score E Sequences producing significant alignments: (bits) Value CHR225 (CHR225Q) /CSM/CH/CHR2-B/CHR

  20. 48 CFR 225.872-6 - Audit.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Audit. 225.872-6 Section...-6 Audit. (a) Memoranda of understanding with some qualifying countries contain annexes that provide for reciprocal “no-cost” audits of contracts and subcontracts (pre- and post-award). (b) To...

  1. 29 CFR 553.225 - Early relief.

    2010-07-01

    ... by the employer, the time involved must be added to the employee's tour of duty and treated as... Enforcement Employees of Public Agencies Tour of Duty and Compensable Hours of Work Rules § 553.225 Early... pursuant to employee agreement, either expressed or implied. This practice will not have the effect...

  2. 48 CFR 225.7501 - Policy.

    2010-10-01

    ... manufacturer or its supplier; (iv) An industrial gas; (v) A brand drug specified by the Defense Medical... low offer (see Subpart 225.5) is an offer of an end product that— (i) Is a qualifying country end product; (ii) Is an eligible product; or (iii) Is a nonqualifying country end product, but application...

  3. 48 CFR 225.7003-3 - Exceptions.

    2010-10-01

    ... requests to the Under Secretary of Defense (Acquisition, Technology, and Logistics) (USD(AT&L)) for a... qualifying country. (5) Specialty metal in any of the items listed in 225.7003-2 if the USD(AT&L), or an... domestic nonavailability determination), requires the approval of the USD(AT&L). (A) At least 30...

  4. 44 CFR 206.225 - Emergency work.

    2010-10-01

    ... HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE Public Assistance Eligibility § 206.225... economically eliminates the need for temporary housing. The work will be limited to that necessary for the... communications. Emergency communications necessary for the purpose of carrying out disaster relief functions...

  5. 21 CFR 225.115 - Complaint files.

    2010-04-01

    ... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Records and Reports § 225.115 Complaint files. (a... current good manufacturing practices. These complaints and experiences may reveal the existence of manufacturing problems not otherwise detected through the normal quality control procedures. Timely...

  6. 21 CFR 225.80 - Labeling.

    2010-04-01

    ... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Packaging and Labeling § 225.80 Labeling. (a... adhered to, will assure that the article is safe and effective for its intended purposes. (b)(1) Labels... medicated feed and includes adequate information for the safe and effective use of the medicated feed....

  7. 21 CFR 137.225 - Whole durum flour.

    2010-04-01

    ... Flours and Related Products § 137.225 Whole durum flour. Whole durum wheat flour conforms to the..., prescribed for whole wheat flour by § 137.200, except that cleaned durum wheat, instead of cleaned wheat... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Whole durum flour. 137.225 Section 137.225...

  8. 14 CFR 13.225 - Offer of proof.

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Offer of proof. 13.225 Section 13.225... INVESTIGATIVE AND ENFORCEMENT PROCEDURES Rules of Practice in FAA Civil Penalty Actions § 13.225 Offer of proof. A party whose evidence has been excluded by a ruling of the administrative law judge may offer...

  9. 12 CFR 225.131 - Activities closely related to banking.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Activities closely related to banking. 225.131 Section 225.131 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... Holding Companies Interpretations § 225.131 Activities closely related to banking. (a) Bank...

  10. 12 CFR 225.123 - Activities closely related to banking.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Activities closely related to banking. 225.123 Section 225.123 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... Holding Companies Interpretations § 225.123 Activities closely related to banking. (a) Effective June...

  11. 12 CFR 225.129 - Activities closely related to banking.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Activities closely related to banking. 225.129 Section 225.129 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... Holding Companies Interpretations § 225.129 Activities closely related to banking. Courier activities....

  12. 25 CFR 225.26 - Auditing and accounting.

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Auditing and accounting. 225.26 Section 225.26 Indians... SOLID MINERALS AGREEMENTS Minerals Agreements § 225.26 Auditing and accounting. The Secretary may... agreement. Procedures and standards used for accounting and auditing of minerals agreements will be...

  13. 29 CFR 22.5 - Review by the reviewing official.

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Review by the reviewing official. 22.5 Section 22.5 Labor Office of the Secretary of Labor PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 22.5 Review by the reviewing official. (a) If, based on the report of the investigating official under § 22.4(b), the reviewing...

  14. Improved limit on the $^{225}$Ra electric dipole moment

    Bishof, Michael; Parker, Richard H.; Bailey, Kevin G.; Greene, John P.; Holt, Roy J.; Kalita, Mukut R.; Korsch, Wolfgang; Lemke, Nathan D.; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas P.; Singh, Jaideep T.; Dietrich, Matthew R.

    2016-01-01

    Background: Octupole-deformed nuclei, such as that of $^{225}$Ra, are expected to amplify observable atomic electric dipole moments (EDMs) that arise from time-reversal and parity-violating interactions in the nuclear medium. In 2015, we reported the first "proof-of-principle" measurement of the $^{225}$Ra atomic EDM. Purpose: This work reports on the first of several experimental upgrades to improve the statistical sensitivity of our $^{225}$Ra EDM measurements by orders of magnitude and eva...

  15. 12 CFR 225.124 - Foreign bank holding companies.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Foreign bank holding companies. 225.124 Section... SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.124 Foreign bank holding companies. (a) Effective December 1, 1971,...

  16. 12 CFR 225.125 - Investment adviser activities.

    2010-01-01

    ... and that their securities are distributed to the public by such affiliated investment advisers, or... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Investment adviser activities. 225.125 Section... Companies Interpretations § 225.125 Investment adviser activities. (a) Effective February 1, 1972, the...

  17. 49 CFR 225.33 - Internal Control Plans.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Internal Control Plans. 225.33 Section 225.33....33 Internal Control Plans. (a) Each railroad shall adopt and comply with a written Internal Control... official business. Each railroad shall amend its Internal Control Plan, as necessary, to reflect...

  18. 22 CFR 225.112 - Review by institution.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Review by institution. 225.112 Section 225.112... institution. Research covered by this policy that has been approved by an IRB may be subject to further appropriate review and approval or disapproval by officials of the institution. However, those officials...

  19. 29 CFR 778.225 - Talent fees excludable under regulations.

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Talent fees excludable under regulations. 778.225 Section 778.225 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS OVERTIME COMPENSATION Payments That May Be Excluded From...

  20. Dicty_cDB: VFF225 [Dicty_cDB

    Full Text Available VF (Link to library) VFF225 (Link to dictyBase) - - - Contig-U15602-1 VFF225P (Link to Original ... B028630 |AB028630.1 Clostridium perfringens hyp27, bacH , ptp, cpd genes for hypothetical protein, bacteria ...

  1. 12 CFR 225.132 - Acquisition of assets.

    2010-01-01

    ... obtaining Board approval pursuant to section 4(c) (8) and the Board's Regulation Y (12 CFR 225.4(b)). (b) In... the Board's Regulation Y (12 CFR 225.4(c)(3)) generally prohibits a bank holding company or its... any merger “or acquisition of assets other than in the ordinary course of business” without...

  2. 40 CFR 225.4 - Waiver by Administrator.

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Waiver by Administrator. 225.4 Section... ENGINEERS DREDGED MATERIAL PERMITS § 225.4 Waiver by Administrator. The Administrator shall grant the... (including spawning and breeding areas), wildlife, or recreational areas. Notice of the Administrator's...

  3. 48 CFR 225.870-8 - Industrial security.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Industrial security. 225... Coordination 225.870-8 Industrial security. Industrial security for Canada shall be in accordance with the U.S.-Canada Industrial Security Agreement of March 31, 1952, as amended....

  4. 14 CFR 417.225 - Debris risk analysis.

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Debris risk analysis. 417.225 Section 417... OF TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.225 Debris risk analysis. A flight safety analysis must demonstrate that the risk to the public potentially exposed to inert...

  5. Dicty_cDB: CHB225 [Dicty_cDB

    Full Text Available CH (Link to library) CHB225 (Link to dictyBase) - - - Contig-U16517-1 CHB225P (Link to Original ... *edmqvqv*ekviy*elkiffhlqevl lnvvykvfqifilninhyymif*ivf *rtn*kkplihtyqqlnqerdhkm*lylwlvvsl mkrh*pftllil*ilv ...

  6. 21 CFR 225.1 - Current good manufacturing practice.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Current good manufacturing practice. 225.1 Section...) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS General Provisions § 225.1 Current good manufacturing practice. (a) Section 501(a)(2)(B) of the Federal Food, Drug, and Cosmetic...

  7. 48 CFR 252.225-7041 - Correspondence in English.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Correspondence in English... of Provisions And Clauses 252.225-7041 Correspondence in English. As prescribed in 225.1103(2), use the following clause: Correspondence in English (JUN 1997) The Contractor shall ensure that...

  8. 5 CFR 532.225 - Nonappropriated fund survey jobs.

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Nonappropriated fund survey jobs. 532.225... PREVAILING RATE SYSTEMS Prevailing Rate Determinations § 532.225 Nonappropriated fund survey jobs. (a) A lead agency shall survey the following required jobs: Job title Job grade Janitor (Light) 1 Food...

  9. 25 CFR 225.1 - Purpose and scope.

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Purpose and scope. 225.1 Section 225.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS OIL AND GAS, GEOTHERMAL, AND SOLID... Development Act of 1982, 25 U.S.C. 2101-2108 (IMDA). These regulations are applicable to the lands...

  10. 25 CFR 225.22 - Approval of minerals agreements.

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Approval of minerals agreements. 225.22 Section 225.22 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS OIL AND GAS, GEOTHERMAL... required, with section 102(2)(C) of the National Environmental Policy Act of 1969 (42 U.S.C. 4332(2)(C))...

  11. 7 CFR 1280.225 - Books and records of persons.

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Books and records of persons. 1280.225 Section 1280... PROMOTION, RESEARCH, AND INFORMATION ORDER Lamb Promotion, Research, and Information Order Reports, Books, and Records § 1280.225 Books and records of persons. (a) Each first handler, exporter of lambs,...

  12. 48 CFR 225.7402-3 - Government support.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government support. 225... States 225.7402-3 Government support. (a) Government support that may be authorized or required for... coordination with the combatant commander that— (1) Such Government support is available and is needed...

  13. 48 CFR 225.7403-2 - Contract clause.

    2010-10-01

    ..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Defense Contractors Outside the United States 225.7403-2 Contract clause. Use the clause at 252.225-7043, Antiterrorism/Force Protection Policy... performance or travel outside the United States, except for contracts with— (a) Foreign governments;...

  14. 14 CFR 121.225 - Propeller deicing fluid.

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Propeller deicing fluid. 121.225 Section 121.225 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS AND OPERATORS FOR COMPENSATION OR HIRE: CERTIFICATION AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND...

  15. 33 CFR 106.225 - Drill and exercise requirements.

    2010-07-01

    ...) Exercises are a full test of the Facility Security Plan and must include substantial and active.... 106.225 Section 106.225 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARINE SECURITY: OUTER CONTINENTAL SHELF (OCS) FACILITIES Outer Continental Shelf...

  16. 48 CFR 52.225-5 - Trade Agreements.

    2010-10-01

    ... following: textiles and apparel articles; footwear, handbags, luggage, flat goods, work gloves, and leather... clause) Editorial Note: For Federal Register citations affecting § 52.225-5, see the List of CFR...

  17. 48 CFR 252.225-7037 - Evaluation of Offers for Air Circuit Breakers.

    2010-10-01

    ... Air Circuit Breakers. 252.225-7037 Section 252.225-7037 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.225-7037 Evaluation of Offers for Air Circuit Breakers. As prescribed in 225.7006-4(a), use the following provision: Evaluation of Offers for Air Circuit Breakers...

  18. 48 CFR 252.225-7031 - Secondary Arab boycott of Israel.

    2010-10-01

    ... Israel. 252.225-7031 Section 252.225-7031 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.225-7031 Secondary Arab boycott of Israel. As prescribed in 225.7605, use the following provision: Secondary Arab Boycott of Israel (JUN 2005) (a) Definitions. As used...

  19. 48 CFR 252.225-7008 - Restriction on Acquisition of Specialty Metals.

    2010-10-01

    ... of Specialty Metals. 252.225-7008 Section 252.225-7008 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.225-7008 Restriction on Acquisition of Specialty Metals. As prescribed in 225.7003-5(a)(1), use the following clause: Restriction on Acquisition of Specialty Metals...

  20. Encapsulation of α-Particle–Emitting 225Ac3+ Ions Within Carbon Nanotubes

    Matson, Michael L.; Villa, Carlos H.; Ananta, Jeyarama S.; Law, Justin J.; Scheinberg, David A.; Wilson, Lon J.

    2016-01-01

    225Ac3+ is a generator of α-particle–emitting radionuclides with 4 net α-particle decays that can be used therapeutically. Targeting 225Ac3+ by use of ligands conjugated to traditional bifunctional chelates limits the amount of 225Ac3+ that can be delivered. Ultrashort, single-walled carbon nanotubes (US-tubes), previously demonstrated as sequestering agents of trivalent lanthanide ions and small molecules, also successfully incorporate 225Ac3+. Methods Aqueous loading of both 225Ac3+ ions and Gd3+ ions via bath sonication was used to construct 225Ac@gadonanotubes (225Ac@GNTs). The 225Ac@GNTs were subsequently challenged with heat, time, and human serum. Results US-tubes internally loaded with both 225Ac3+ ions and Gd3+ ions show 2 distinct populations of 225Ac3+ ions: one rapidly lost in human serum and one that remains bound to the US-tubes despite additional challenge with heat, time, and serum. The presence of the latter population depended on cosequestration of Gd3+ and 225Ac3+ ions. Conclusion US-tubes successfully sequester 225Ac3+ ions in the presence of Gd3+ ions and retain them after a human serum challenge, rendering 225Ac@GNTs candidates for radioimmunotherapy for delivery of 225Ac3+ ions at higher concentrations than is currently possible for traditional ligand carriers. PMID:25931476

  1. Improved experimental limit on the EDM of 225Ra

    Bishof, Michael; Bailey, Kevin; Dietrich, Matthew R.; Greene, John P.; Holt, Roy J.; Kalita, Mukut R.; Korsch, Wolfgang; Lemke, Nathan D.; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Tom P.; Parker, Richard H.; Rabga, Tenzin; Singh, Jaideep T.

    2015-10-01

    Searches for permanent electric dipole moments (EDMs) in fundamental and composite particles are sensitive probes of beyond-standard-model symmetry violation that could explain the dominance of matter over anti-matter. The 225Ra (t1/2 = 15d, I = 1/2) atom is a particularly attractive system to use for an EDM measurement because its large nuclear octupole deformation, closely spaced ground-state parity doublet, and large atomic mass make 225Ra uniquely sensitive to symmetry-violating interactions in the nuclear medium. We have developed an experiment to measure the EDM of 225Ra and demonstrated the first ``proof-of-principle'' measurement, giving a 95% confidence upper limit of 5E-22 e-cm. After implementing a vacuum upgrade, we have observed nuclear spin coherence after 20 s of free evolution - a factor of ten improvement over our earlier results - and have lowered the 225Ra EDM limit by over an order of magnitude. Upcoming experimental upgrades have the potential to further improve our EDM sensitivity by many orders of magnitude, allowing us to test symmetry violation at an unprecedented level. This work is supported by U.S. DOE, Office of Science, Office of Nuclear Physics, under Contract DE-AC02-06CH11357.

  2. 40 CFR 98.225 - Procedures for estimating missing data.

    2010-07-01

    ... PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Nitric Acid Production § 98.225 Procedures for... (a) and (b) of this section. (a) For each missing value of nitric acid production, the substitute..., including emission factors, production rate, and N2O concentration, you must conduct a new performance...

  3. Expert Consideration on the Amendment to the INFCIRC/225

    The INFCIRC/225 has played an important role as a guideline for establishing international regimes for physical protection since it was published in 1975 by the IAEA. It has been amended four times to reflect the changes that have taken place with regard to nuclear security. The fourth revision was released in 1999. Since the release of this revision, the international nuclear security environment has changed drastically. Because of the September 11, 2001 terrorist attacks in the USA, an amendment to the CPPNM (Convention on Physical Protection of Nuclear Material) was passed at an international conference held in July of 2005 in Vienna. Many requests for a revision of the INFCIRC/225 have been raised since then. The IAEA had prepared a revised document; and sponsored the first of six meetings in order to amendment the document beginning in February of 2008. A TM (Technical Meeting) was also held in February of 2010. Physical protection experts from 22 countries participated in the meeting. After the TM, a draft document was sent to member states for reviewed for a designated 120 days. If ratified, document will then become the 5th amendment to the INFCIRC/225. The INFCIRC/225 will be used as a basis for physical protection measures specified in the Act. This paper will analyze the revised document and discussed on how it affects our national regime of physical protection

  4. 40 CFR 225.3 - Procedure for invoking economic impact.

    2010-07-01

    ... accordance with 33 CFR 209.120 and 209.145. (b) If the decision of the Chief of Engineers is that ocean... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Procedure for invoking economic impact... DUMPING CORPS OF ENGINEERS DREDGED MATERIAL PERMITS § 225.3 Procedure for invoking economic impact....

  5. 12 CFR 225.28 - List of permissible nonbanking activities.

    2010-01-01

    ... institutions—(i) Industrial banking. Owning, controlling, or operating an industrial bank, Morris Plan bank, or... Feasibility studies do not include assisting management with the planning or marketing for a given project or... itself. See also the Board's interpretation of bank management consulting advice (12 CFR 225.131). (1)...

  6. 7 CFR 225.6 - State agency responsibilities.

    2010-01-01

    ... meet the minimum requirements of 7 CFR 225.13. (b) Approval of sponsor applications. (1) Each State... Accounting Office at any reasonable time and place for a period of 3 years from the date of receipt of final... liability for payment of differences between the number of meals delivered by the food service...

  7. 48 CFR 225.7702 - Acquisition of small arms.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition of small arms... Operations in Iraq or Afghanistan 225.7702 Acquisition of small arms. (a) Except as provided in paragraph (b) of this section, when acquiring small arms for assistance to the Army of Iraq, the Army...

  8. 20 CFR 637.225 - Determination of incentive bonus.

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of incentive bonus. 637.225... of incentive bonus. The amount of the incentive bonus to be paid to each State shall be the total of the incentive bonuses claimed for each eligible individual within the State. The amount of...

  9. 48 CFR 225.7304 - FMS customer involvement.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false FMS customer involvement... Military Sales 225.7304 FMS customer involvement. (a) FMS customers may request that a defense article or... contract without full and open competition. The FMS customer may also request that a subcontract be...

  10. 48 CFR 752.225-71 - Local procurement.

    2010-10-01

    ... and nationality waivers as set forth in subpart F of 22 CFR part 228 except as provided for in 22 CFR... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Local procurement. 752.225... Local procurement. For use in any USAID contract involving performance overseas. Local Procurement...

  11. 33 CFR 183.225 - Flotation test for persons capacity.

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Flotation test for persons... SECURITY (CONTINUED) BOATING SAFETY BOATS AND ASSOCIATED EQUIPMENT Flotation Requirements for Outboard Boats Rated for Engines of More Than 2 Horsepower Tests § 183.225 Flotation test for persons...

  12. 40 CFR 1065.225 - Intake-air flow meter.

    2010-07-01

    ... § 1065.205. This may include a laminar flow element, an ultrasonic flow meter, a subsonic venturi, a... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Intake-air flow meter. 1065.225... flow meter. (a) Application. You may use an intake-air flow meter in combination with a...

  13. An irradiation facility at the 225 cm cyclotron in Stockholm

    An irradiation facility now in operation at the 225 cm cyclotron of the Research Institute for Physics in Stockholm is described. Irradiations are performed in an unfocused and otherwise lost part of the beam. The target can be inserted and extracted from the irradiation position without disturbing simultaneous in-beam measurements. (Auth.)

  14. 27 CFR 28.225 - Removals of beer by brewer.

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Removals of beer by brewer..., DEPARTMENT OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Exportation of Beer With Benefit of Drawback Execution of Claims § 28.225 Removals of beer by brewer. Where a brewer removes taxpaid beer from...

  15. 40 CFR 180.225 - Phosphine; tolerances for residues.

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Phosphine; tolerances for residues...) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.225 Phosphine; tolerances for residues. (a) General. (1) Tolerances are established for...

  16. Improved limit on the $^{225}$Ra electric dipole moment

    Bishof, Michael; Bailey, Kevin G; Greene, John P; Holt, Roy J; Kalita, Mukut R; Korsch, Wolfgang; Lemke, Nathan D; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas P; Singh, Jaideep T; Dietrich, Matthew R

    2016-01-01

    Background: Octupole-deformed nuclei, such as that of $^{225}$Ra, are expected to amplify observable atomic electric dipole moments (EDMs) that arise from time-reversal and parity-violating interactions in the nuclear medium. In 2015, we reported the first "proof-of-principle" measurement of the $^{225}$Ra atomic EDM. Purpose: This work reports on the first of several experimental upgrades to improve the statistical sensitivity of our $^{225}$Ra EDM measurements by orders of magnitude and evaluates systematic effects that contribute to current and future levels of experimental sensitivity. Method: Laser-cooled and trapped $^{225}$Ra atoms are held between two high voltage electrodes in an ultra high vacuum chamber at the center of a magnetically shielded environment. We observe Larmor precession in a uniform magnetic field using nuclear-spin-dependent laser light scattering and look for a phase shift proportional to the applied electric field, which indicates the existence of an EDM. The main improvement to o...

  17. 48 CFR 225.7009 - Restriction on ball and roller bearings.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on ball and roller bearings. 225.7009 Section 225.7009 Federal Acquisition Regulations System DEFENSE ACQUISITION... roller bearings....

  18. 48 CFR 225.7703 - Acquisition of products or services other than small arms.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition of products or services other than small arms. 225.7703 Section 225.7703 Federal Acquisition Regulations System DEFENSE... than small arms....

  19. 48 CFR 225.7003 - Restrictions on acquisition of specialty metals.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restrictions on acquisition of specialty metals. 225.7003 Section 225.7003 Federal Acquisition Regulations System DEFENSE... Restrictions on acquisition of specialty metals....

  20. Improved limit on the 225Ra electric dipole moment

    Bishof, Michael; Parker, Richard H.; Bailey, Kevin G.; Greene, John P.; Holt, Roy J.; Kalita, Mukut R.; Korsch, Wolfgang; Lemke, Nathan D.; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas P.; Singh, Jaideep T.; Dietrich, Matthew R.

    2016-08-01

    Background: Octupole-deformed nuclei, such as that of 225Ra, are expected to amplify observable atomic electric dipole moments (EDMs) that arise from time-reversal and parity-violating interactions in the nuclear medium. In 2015 we reported the first "proof-of-principle" measurement of the 225Ra atomic EDM. Purpose: This work reports on the first of several experimental upgrades to improve the statistical sensitivity of our 225Ra EDM measurements by orders of magnitude and evaluates systematic effects that contribute to current and future levels of experimental sensitivity. Method: Laser-cooled and trapped 225Ra atoms are held between two high-voltage electrodes in an ultrahigh-vacuum chamber at the center of a magnetically-shielded environment. We observe Larmor precession in a uniform magnetic field using nuclear-spin-dependent laser light scattering and look for a phase shift proportional to the applied electric field, which indicates the existence of an EDM. The main improvement to our measurement technique is an order-of-magnitude increase in spin-precession time, which is enabled by an improved vacuum system and a reduction in trap-induced heating. Results: We have measured the 225Ra atomic EDM to be less than 1.4 ×10-23e cm (95 % confidence upper limit), which is a factor of 36 improvement over our previous result. Conclusions: Our evaluation of systematic effects shows that this measurement is completely limited by statistical uncertainty. Combining this measurement technique with planned experimental upgrades, we project a statistical sensitivity at the 1 ×10-28e cm level and a total systematic uncertainty at the 4 ×10-29e cm level.

  1. 41 CFR 102-36.225 - Must we report excess related personal property?

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Must we report excess related personal property? 102-36.225 Section 102-36.225 Public Contracts and Property Management Federal... Property § 102-36.225 Must we report excess related personal property? Yes, you must report excess...

  2. 48 CFR 252.225-7030 - Restriction on Acquisition of Carbon, Alloy, and Armor Steel Plate.

    2010-10-01

    ... of Carbon, Alloy, and Armor Steel Plate. 252.225-7030 Section 252.225-7030 Federal Acquisition... Acquisition of Carbon, Alloy, and Armor Steel Plate. As prescribed in 225.7011-3, use the following clause: Restriction on Acquisition of Carbon, Alloy, and Armor Steel Plate (DEC 2006) (a) Carbon, alloy, and...

  3. 12 CFR 225.174 - What aggregate thresholds apply to merchant banking investments?

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What aggregate thresholds apply to merchant banking investments? 225.174 Section 225.174 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF...) Regulations Merchant Banking Investments § 225.174 What aggregate thresholds apply to merchant...

  4. 12 CFR 225.172 - What are the holding periods permitted for merchant banking investments?

    2010-01-01

    ... applicable under the Board's capital adequacy rules or guidelines (see 12 CFR 225 appendix A) to merchant... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What are the holding periods permitted for merchant banking investments? 225.172 Section 225.172 Banks and Banking FEDERAL RESERVE SYSTEM...

  5. 12 CFR 225.126 - Activities not closely related to banking.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Activities not closely related to banking. 225.126 Section 225.126 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE... Financial Holding Companies Interpretations § 225.126 Activities not closely related to banking. Pursuant...

  6. 48 CFR 252.225-7016 - Restriction on acquisition of ball and roller bearings.

    2010-10-01

    ... of ball and roller bearings. 252.225-7016 Section 252.225-7016 Federal Acquisition Regulations System... and roller bearings. As prescribed in 225.7009-5, use the following clause: Restriction on Acquisition of Ball and Roller Bearings (MAR 2006) (a) Definitions. As used in this clause' (1)...

  7. 48 CFR 225.871 - North Atlantic Treaty Organization (NATO) cooperative projects.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false North Atlantic Treaty Organization (NATO) cooperative projects. 225.871 Section 225.871 Federal Acquisition Regulations System... Other International Agreements and Coordination 225.871 North Atlantic Treaty Organization...

  8. Nuclear Structure Effects in the Exotic Decay of $^{225}$Ac via $^{14}$C Emission

    2002-01-01

    % IS323 \\\\ \\\\ We propose to build at Isolde a high intensity $^{225}$Ac source by $\\beta$-decay of $^{225}$(Ra+Fr) beam, to be used at the superconducting spectrometer SOLENO of IPN-Orsay in order to study a possible fine structure in the spectrum of $^{14}$C ions spontaneously emitted by $^{225}$Ac.

  9. 22 CFR 225.119 - Research undertaken without the intention of involving human subjects.

    2010-04-01

    ... involving human subjects. 225.119 Section 225.119 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.119 Research undertaken without the intention of involving human subjects. In the event research is undertaken without the intention of involving human subjects, but it...

  10. 22 CFR 225.118 - Applications and proposals lacking definite plans for involvement of human subjects.

    2010-04-01

    ... plans for involvement of human subjects. 225.118 Section 225.118 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.118 Applications and proposals lacking definite plans for involvement of human subjects. Certain types of applications for grants,...

  11. 48 CFR 252.225-7038 - Restriction on Acquisition of Air Circuit Breakers.

    2010-10-01

    ... of Air Circuit Breakers. 252.225-7038 Section 252.225-7038 Federal Acquisition Regulations System... Circuit Breakers. As prescribed in 225.7006-4(b), use the following clause: Restriction on Acquisition of Air Circuit Breakers (JUN 2005) Unless otherwise specified in its offer, the Contractor shall...

  12. 48 CFR 225.873 - Waiver of United Kingdom commercial exploitation levies.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Waiver of United Kingdom commercial exploitation levies. 225.873 Section 225.873 Federal Acquisition Regulations System DEFENSE... International Agreements and Coordination 225.873 Waiver of United Kingdom commercial exploitation levies....

  13. 48 CFR 52.225-14 - Inconsistency between English Version and Translation of Contract.

    2010-10-01

    ... English Version and Translation of Contract. 52.225-14 Section 52.225-14 Federal Acquisition Regulations... CLAUSES Text of Provisions and Clauses 52.225-14 Inconsistency between English Version and Translation of Contract. As prescribed in 25.1103(b), insert the following clause: Inconsistency Between English...

  14. 48 CFR 225.403 - World Trade Organization Government Procurement Agreement and Free Trade Agreements.

    2010-10-01

    ... Government Procurement Agreement and Free Trade Agreements. 225.403 Section 225.403 Federal Acquisition... FOREIGN ACQUISITION Trade Agreements 225.403 World Trade Organization Government Procurement Agreement and Free Trade Agreements. (c) For acquisitions of supplies covered by the World Trade...

  15. 48 CFR 252.225-7010 - Commercial Derivative Military Article-Specialty Metals Compliance Certificate.

    2010-10-01

    ... Military Article-Specialty Metals Compliance Certificate. 252.225-7010 Section 252.225-7010 Federal... Military Article—Specialty Metals Compliance Certificate. As prescribed in 225.7003-5(b), use the following provision: Commercial Derivative Military Article—Specialty Metals Compliance Certificate (JUL 2009)...

  16. 27 CFR 25.225 - Destruction of taxpaid beer which was never removed from brewery premises.

    2010-04-01

    ... beer which was never removed from brewery premises. 25.225 Section 25.225 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Voluntary Destruction § 25.225 Destruction of taxpaid beer which was never removed from brewery premises. (a) General....

  17. First Measurement of the Atomic Electric Dipole Moment of $^{225}$Ra

    Parker, R H; Kalita, M R; Lemke, N D; Bailey, K G; Bishof, M N; Greene, J P; Holt, R J; Korsch, W; Lu, Z -T; Mueller, P; O'Connor, T P; Singh, J T

    2015-01-01

    The radioactive radium-225 ($^{225}$Ra) atom is a favorable case to search for a permanent electric dipole moment (EDM). Due to its strong nuclear octupole deformation and large atomic mass, $^{225}$Ra is particularly sensitive to interactions in the nuclear medium that violate both time-reversal symmetry and parity. We have developed a cold-atom technique to study the spin precession of $^{225}$Ra atoms held in an optical dipole trap, and demonstrated the principle of this method by completing the first measurement of its atomic EDM, reaching an upper limit of $|$$d$($^{225}$Ra)$|$ $<$ $5.0\\!\\times\\!10^{-22}$ $e \\cdot$cm (95$\\%$ confidence).

  18. Muoproduction of neutral strange hadrons at 225 GeV

    The production of K/sub s/ 0, Λ0, and Lambda-bar0 has been measured in deep-inelastic muon scattering at 225 GeV; decays into two charged hadrons were detected. Momentum distributions are compared to the inclusive charged-hadron distributions measured in the same experiment. The range of virtual-photon parameters covered is 0.422 and 20<ν<210 GeV

  19. An improved limit on the EDM of 225 Ra

    Bishof, Michael; Bailey, Kevin; Dietrich, Matthew R.; Greene, John P.; Holt, Roy J.; Kalita, Mukut R.; Korsch, Wolfgang; Lemke, Nathan D.; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas P.; Parker, Richard H.; Rabga, Tenzin; Singh, Jaideep T.

    2016-05-01

    Searches for permanent electric dipole moments (EDMs) are sensitive probes of symmetry violation that could explain the dominance of matter over anti-matter. The 225 Ra (t1/2 = 15 days, I = 1/2) atom is a particularly attractive system to use for an EDM measurement because its octupole-deformed nucleus, closely spaced ground-state parity doublet, and large nuclear charge make 225 Ra uniquely sensitive to symmetry-violating interactions in the nuclear medium. In 2015, we reported the first ``proof of principle'' measurement of the 225 Ra EDM, giving a 95% confidence upper limit of 5* 10-22 e-cm; representing the first EDM measurement using laser-trapped atoms as well as the first EDM measurement of an atom with an octupole-deformed nucleus. After implementing upgrades to our apparatus, we now observe nuclear spin coherence after 20 s of free evolution - a factor of ten improvement. A new EDM measurement based on the upgraded system improved the 95% confidence upper limit by a factor of 36. We also report on the progress of current experimental upgrades that have the potential to further improve our EDM sensitivity by many orders of magnitude, allowing us to test symmetry violation at an unprecedented level. This work is supported by U.S. DOE, Office of Science, Office of Nuclear Physics, under Contract DE-AC02-06CH11357.

  20. Search for a Permanent Electric Dipole Moment of 225Ra

    Kalita, Mukut Ranjan

    The observation of a permanent electric dipole moment (EDM) in a non-degenerate system would indicate the violation of discrete symmetries of Time reversal (T) or combined application of Charge (C) and Parity (P) symmetry violation through the CPT theorem. The diamagnetic 225Ra atom with nuclear spin I=1/2 is a favorable candidate for an EDM search. Experimental sensitivity to its EDM is enhanced due to its high atomic mass and the increased Schiff moment of its octupole deformed nucleus. An experimental setup is developed where laser cooled neutral radium atoms are collected in a magneto-optical trap (MOT). The collected atoms are transported 1 meter with a far off-resonant optical dipole trap (ODT) and then the atoms are transferred to a second standing-wave ODT in an experimental chamber. The atoms are then optically polarized and allowed to Larmor precess in parallel and antiparallel electric and magnetic fields. The difference between the Larmor precession frequency for parallel and antiparallel fields is experimentally determined to measure the EDM. This thesis is about the first measurement of the EDM of the 225Ra atom where an upper limit of |d(225Ra)| EDM, CP violation, laser cooling and trapping, rare isotopes, radium.

  1. Effect of niobium on the embrittlement of 2.25 Cr and 2.25 Cr-1Mo steels by phosphous

    The influence of niobium on the temper embrittlement of 2.25Cr and 2.25 Cr-1Mo steels doped with phosphorus is evaluated. The transition temperatures of the samples tempered at 6500C and aged at different temperatures for niobium steels. (M.J.C.)

  2. NIR photometry of the flaring Quasar PKS050-225

    Carrasco, L.; Recillas, E.; Escobedo, G.; Carraminana, D. Y. Mayya. A.

    2012-11-01

    Following the report of a Gamma Ray flare in this object by M. Dutka et al. (Atel # 4574), we observed a recent NIR brightening of the high redshift, PKS0250-225 also known as CGRaBSJ0252-2219 z=1.419), cross identified with the gamma ray source 2FGLJ0252.7-2218. On November 24th 2012 (JD 2456255.7662), we determined the following photometric values H = 15.592+/- 0.05, J = 16.570 +/- 0.04 and Ks = 14.653 +/- 0.06.

  3. Combined effects of C225 and 125-iodine seed radiation on colorectal cancer cells

    To characterize the effect of combined treatment of the anti-epidermal growth factor receptor (EGFR) monoclonal antibody C225 and 125-iodine (125I) seed radiation in human colorectal cancer. We treated LS180 cells with 125I continuous low dose rate radiation in the presence and absence of 100 nM C225. The clonogenic capacity, cellular proliferation, cell cycle distribution, apoptosis, and molecular pathways of the cells following the treatments were analyzed in vitro. The sensitizer enhancement ratio of C225 was approximately 1.4. Treatment with C225 and radiation alone produced significant inhibition of cell growth, but combination therapy produced greater inhibition than either treatment administered alone. C225 increased the radiation-induced apoptosis and the fraction of γ-H2AX foci positive cells at 48 h after treatment. The Akt phosphorylation level was lower in the cells receiving the combination treatment than in the cells treated with radiation or C225 alone. These findings indicate that C225 sensitizes LS180 cells to 125I seed radiation. Growth inhibition is mediated by inducing apoptosis and not cell cycle arrest. Additionally, we confirmed that C225 impairs DNA repair by reducing the cellular level of the DNA-PKcs and Ku70 proteins. Furthermore, the inhibition of Akt signaling activation may be responsible for the C225-mediated radiosensitization

  4. 48 CFR 252.225-7032 - Waiver of United Kingdom Levies-Evaluation of offers.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Waiver of United Kingdom... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7032 Waiver of United Kingdom Levies—Evaluation of offers. As prescribed in 225.1101(8), use the following provision: Waiver of United...

  5. 48 CFR 252.225-7033 - Waiver of United Kingdom levies.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Waiver of United Kingdom... of Provisions And Clauses 252.225-7033 Waiver of United Kingdom levies. As prescribed in 225.1101(9), use the following clause: Waiver of United Kingdom Levies (APR 2003) (a) The U.S. Government...

  6. 48 CFR 225.7011 - Restriction on carbon, alloy, and armor steel plate.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on carbon, alloy, and armor steel plate. 225.7011 Section 225.7011 Federal Acquisition Regulations System DEFENSE... on carbon, alloy, and armor steel plate....

  7. 42 CFR 22.5 - Leave without pay while on detail.

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Leave without pay while on detail. 22.5 Section 22... OTHER THAN COMMISSIONED OFFICERS Special Consultants § 22.5 Leave without pay while on detail. The... the period of a detail to a State, a subdivision thereof, or a private non-profit institution and...

  8. 76 FR 54527 - Fourth Meeting: RTCA Special Committee 225: Rechargeable Lithium Batteries and Battery Systems...

    2011-09-01

    ... and Battery Systems--Small and Medium Sizes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 225 meeting: Rechargeable Lithium Batteries and Battery Systems--Small... Special Committee 225: Rechargeable Lithium Batteries and Battery Systems--Small and Medium Sizes....

  9. 76 FR 38741 - Third Meeting: RTCA Special Committee 225: Rechargeable Lithium Batteries and Battery Systems...

    2011-07-01

    ... and Battery Systems--Small and Medium Sizes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 225 meeting: Rechargeable Lithium Batteries and Battery Systems--Small... Special Committee 225: Rechargeable Lithium Batteries and Battery Systems--Small and Medium Sizes....

  10. 76 FR 6180 - First Meeting: RTCA Special Committee 225: Rechargeable Lithium Batteries and Battery Systems...

    2011-02-03

    ... and Battery Systems--Small and Medium Sizes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 225 meeting: Rechargeable Lithium Batteries and Battery Systems--Small... Special Committee 225: Rechargeable Lithium Batteries and Battery Systems--Small and Medium Sizes....

  11. 76 FR 22161 - Second Meeting: RTCA Special Committee 225: Rechargeable Lithium Batteries and Battery Systems...

    2011-04-20

    ... and Battery Systems--Small and Medium Sizes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 225 meeting: Rechargeable Lithium Batteries and Battery Systems--Small... Special Committee 225: Rechargeable Lithium Batteries and Battery Systems--Small and Medium Sizes....

  12. 48 CFR 225.7006 - Restriction on air circuit breakers for naval vessels.

    2010-10-01

    ... on air circuit breakers for naval vessels. ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on air circuit breakers for naval vessels. 225.7006 Section 225.7006 Federal Acquisition Regulations System...

  13. 12 CFR 225.102 - Bank holding company indirectly owning nonbanking company through subsidiaries.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Bank holding company indirectly owning nonbanking company through subsidiaries. 225.102 Section 225.102 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN...

  14. 20 CFR 225.33 - Months for which DRC's are due.

    2010-04-01

    ... Section 225.33 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT PRIMARY INSURANCE AMOUNT DETERMINATIONS Delayed Retirement Credits § 225.33 Months for which DRC's are due. (a) A DRC is due for each month after 1970 in which the employee is— (1) Full retirement age or...

  15. 7 CFR Appendix C to Part 225 - Child Nutrition (CN) Labeling Program

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Child Nutrition (CN) Labeling Program C Appendix C to... Appendix C to Part 225—Child Nutrition (CN) Labeling Program 1. The Child Nutrition (CN) Labeling Program... 7 CFR 210.10, 225.16, and 226.20 and are served in the main dish. (b) Juice drinks and juice...

  16. 40 CFR 80.225 - What is the definition of a small refiner?

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false What is the definition of a small refiner? 80.225 Section 80.225 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... company and subsidiaries of the parent company, and any joint venture partners. A subsidiary under...

  17. 12 CFR Appendix F to Part 225 - Interagency Guidelines Establishing Information Security Standards

    2010-01-01

    ... (FDIC); and 12 CFR part 570, app. B (OTS). The “Interagency Guidelines Establishing Information Security.... 225, App. F Appendix F to Part 225—Interagency Guidelines Establishing Information Security Standards.... Standards for Safeguarding Customer Information A. Information Security Program B. Objectives...

  18. 48 CFR 652.225-70 - Arab League Boycott of Israel.

    2010-10-01

    ... Israel. 652.225-70 Section 652.225-70 Federal Acquisition Regulations System DEPARTMENT OF STATE CLAUSES... League Boycott of Israel. As prescribed in 625.7002(a), insert the following provision: Arab League Boycott of Israel (AUG 1999) (a) Definitions. As used in this provision: Foreign person means any...

  19. 46 CFR 10.225 - Requirements for original merchant mariner credentials.

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Requirements for original merchant mariner credentials. 10.225 Section 10.225 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN MERCHANT MARINER CREDENTIAL General Requirements for All Merchant Mariner Credentials §...

  20. FORECASTING NIKKEI 225 INDEX WITH SUPPORT VECTOR MACHINE

    HUANG Wei; Yoshiteru Nakamori; WANG Shouyang; YU Lean

    2003-01-01

    Support Vector Machine (SVM) is a very specific type of learning algorithms characterized by the capacity control of the decision function, the use of the kernel functions and the sparsity of the solution. In this paper, we investigate the predictability of financial movement direction with SVM by forecasting the weekly movement direction of NIKKEI 225 index. To evaluate the forecasting ability of SVM, we compare the performance with those of Linear Discriminant Analysis, Quadratic Discriminant Analysis and Elman Backpropagation Neural Networks. The experiment results show that SVM outperforms other classification methods. Furthermore, we propose a combining model by integrating SVM with other classification methods. The combining model performs the best among the forecasting methods.

  1. 40 CFR 1048.225 - How do I amend my application for certification to include new or modified engine configurations?

    2010-07-01

    ... already covered by a certificate of conformity, you may start producing the new or modified engine... certification to include new or modified engine configurations? 1048.225 Section 1048.225 Protection of..., LARGE NONROAD SPARK-IGNITION ENGINES Certifying Engine Families § 1048.225 How do I amend my...

  2. 48 CFR 52.225-3 - Buy American Act-Free Trade Agreements-Israeli Trade Act.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Buy American Act-Free Trade Agreements-Israeli Trade Act. 52.225-3 Section 52.225-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.225-3...

  3. 12 CFR 225.145 - Limitations established by the Competitive Equality Banking Act of 1987 on the activities and...

    2010-01-01

    ... provisions of the Board's Regulation Y (12 CFR 225.52). 1 12 U.S.C. 1843(f). Such a company is treated as a..., credit card and mortgage lending. 12 CFR 225.25(b)(1). Finally, CEBA itself recognizes the specialized... a business. See 12 CFR 225.25(b)(3). Similarly, the trust company exemption from the bank...

  4. 12 CFR 225.130 - Issuance and sale of short-term debt obligations by bank holding companies.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Issuance and sale of short-term debt obligations by bank holding companies. 225.130 Section 225.130 Banks and Banking FEDERAL RESERVE SYSTEM... CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.130 Issuance and...

  5. Importance of maintenance therapy in C225-induced enhancement of tumor control by fractionated radiation

    Purpose: C225 strongly enhances tumor radioresponse when given concurrently with radiotherapy. We investigated whether additional therapeutic benefit could be achieved by continuing maintenance treatment with C225 after the completion of fractionated radiotherapy. Methods and Materials: A431 xenografts were treated with local irradiation or combined with C225 by two different schedules: (1) 6 h before the first dose of irradiation and at 3-day intervals for a total of 3 doses during the 7-day fractionated radiotherapy, or (2) 6 doses of C225 given both during radiotherapy and continuing for 3 additional doses after radiotherapy. Tumor cure was assessed by the radiation dose yielding local tumor control in 50% of animals (TCD50), and time to recurrence was also determined. Results: Both treatment schedules increased radiocurability as evidenced by reductions in TCD50, but the effect was greater when C225 was given both during and after radiotherapy. C225 reduced the TCD50 of 83.1 (73.2-124.8) Gy by radiation only to 46.2 (39.1-57.5) Gy when given during radiotherapy and to 30.8 (22.2-38.0) Gy when given during and after radiotherapy. Dose modification factors were 1.8 when C225 was given during radiotherapy and 2.7 when given both during and after radiotherapy. C225 was also effective in delaying the onset of tumor recurrences, and was more effective when given as both concurrent and maintenance therapy. Conclusions: Data showed that C225 strongly enhanced the curative effect of fractionated radiation, and its effect was greater if administration was extended beyond the end of radiotherapy. This important finding may influence future designs of clinical trials combining anti-EGFR (anti-epidermal growth factor receptor) agents with radiotherapy

  6. Results of the Test Program for Replacement of AK-225G Solvent for Cleaning NASA Propulsion Oxygen Systems

    Lowrey, Nikki M.; Mitchell, Mark A.

    2016-01-01

    Since the 1990's, when the Class I Ozone Depleting Substance chlorofluorocarbon-113 was banned, NASA's propulsion test facilities at Marshall Space Flight Center and Stennis Space Center have relied upon the solvent Asahiklin AK-225 (hydrochlorofluorocarbon-225ca/cb or HCFC-225ca/cb) and, more recently AK-225G (the single isomer form, HCFC-225cb) to safely clean and verify the cleanliness of large scale propulsion oxygen systems. Effective January 1, 2015, the production, import, export, and new use of Class II Ozone Depleting Substances, including AK-225G, was prohibited in the United States by the Clean Air Act. In 2012 through 2014, NASA test labs at MSFC, SSC, and Johnson Space Center's White Sands Test Facility collaborated to seek out, test, and qualify a solvent replacement for AK-225G that is both an effective cleaner and safe for use with oxygen systems. This paper summarizes the tests performed, results, and lessons learned.

  7. Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles

    Alpha radionuclide therapy is steadily gaining importance and a large number of pre-clinical and clinical studies have been carried out. However, due to the recoil effects the daughter recoil atoms, most of which are alpha emitters as well, receive energies that are much higher than the energies of chemical bonds resulting in decoupling of the radionuclide from common targeting agents. Here, we demonstrate that polymer vesicles (i.e. polymersomes) can retain recoiling daughter nuclei based on an experimental study examining the retention of 221Fr and 213Bi when encapsulating 225Ac. - Highlights: • First reported loading of 213Bi and 225Ac in polymer vesicles (i.e. polymersomes). • Encapsulating 225Ac in polymersomes results in up to 69 % recoil retention of 221Fr. • Encapsulating 225Ac in polymersomes results in up to 53 % recoil retention of 213Bi

  8. 25 CFR 225.29 - Corporate qualifications and requests for information.

    2010-04-01

    ... OIL AND GAS, GEOTHERMAL, AND SOLID MINERALS AGREEMENTS Minerals Agreements § 225.29 Corporate..., constitutes certification that the individual signing (except a surety agent) is authorized to act in such...

  9. Search for Electric dipole moment (EDM) in laser cooled and trapped 225Ra atoms

    Kalita, Mukut; Bailey, Kevin; Dietrich, Matthew; Green, John; Holt, Roy; Korsch, Wolfgang; Lu, Zheng-Tian; Lemke, Nathan; Mueller, Peter; O'Connor, Tom; Parker, Richard; Singh, Jaideep; Trimble, Will; Argonne National Laboratory Collaboration; University Of Chicago Collabration; University Of Kentucky Collaboration

    2014-05-01

    We are searching for an EDM of the diamagnetic 225Ra atom. 225Ra has nuclear spin I =1/2. Experimental sensitivity to its EDM is enhanced due to its heavy mass and the increased Schiff moment of its octupole deformed nucleus. Our experiment involves collecting laser cooled Ra atoms in a magneto-optical trap (MOT), transporting them 1 meter with a far off-resonant optical dipole trap (ODT) and then transferring the atoms to a second standing-wave ODT in our experimental chamber. We will report our recent experiences in polarizing and observing Larmor precession of 225Ra atoms in parallel electric and magnetic fields in a magnetically shielded region and progress towards a first measurement of the EDM of 225Ra. This work is supported by DOE, Office of Nuclear Physics, under contract No. DE-AC02-06CH11357 and contract No. DE-FG02-99ER41101.

  10. A two-dimensional phase separation on the spherical surface of the metallic glass Au55Pb22.5Sb22.5

    Lee, M. C.; Johnson, W. L.

    1982-01-01

    Recent experiments indicate that a phase separation in a spherical sample of the metallic glass Au55Pb22.5Sb22.5 occurs near the surface of the sphere. This strongly suggests either a contribution of surface-free energy to the decomposition process or a possible influence of near surface impurities absorbed during synthesis of the sphere. The surface phase separation has been studied as a function of cooling rate of the sphere. At high cooling rates (small sphere sizes), the surface separation disappears altogether suggesting that the surface of the parent liquid droplet is initially homogeneous.

  11. Performance and beam characteristics of the PANTAK THERAPAX HF225 X-ray therapy machine

    The performance and beam characteristics of the new PANTAK THERAPAX HF225 X-ray therapy machine have been measured, evaluated and discussed. Eight beam qualities within the working range of generating potentials between 50 and 225 kVp are used in our department. These beam qualities have been investigated in order to provide a data base specific to our machine. Beam Quality, Central Axis Depth Dose, Output, Relative Field Uniformity and Timer Error were investigated. (authors)

  12. 12 CFR 225.127 - Investment in corporations or projects designed primarily to promote community welfare.

    2010-01-01

    ..., limited as to the rate of return on his investment in the project, as to rentals or occupancy charges for... (12 U.S.C. 1843(c)(8)) and § 225.25(b)(6) of the Board's Regulation Y (12 CFR 225.25(b)(6)) includes... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Investment in corporations or projects...

  13. Auricular reconstruction of congenital microtia: personal experience in 225 cases.

    Anghinoni, M; Bailleul, C; Magri, A S

    2015-06-01

    Microtia is a congenital disease with various degrees of severity, ranging from the presence of rudimentary and malformed vestigial structures to the total absence of the ear (anotia). The complex anatomy of the external ear and the necessity to provide good projection and symmetry make this reconstruction particularly difficult. The aim of this work is to report our surgical technique of microtic ear correction and to analyse the short and long term results. From 2000 to 2013, 210 patients affected by microtia were treated at the Maxillo-Facial Surgery Division, Head and Neck Department, University Hospital of Parma. The patient population consisted of 95 women and 115 men, aged from 7 to 49 years. A total of 225 reconstructions have been performed in two surgical stages basing of Firmin's technique with some modifications and refinements. The first stage consists in fabrication and grafting of a three-dimensional costal cartilage framework. The second stage is performed 5-6 months later: the reconstructed ear is raised up and an additional cartilaginous graft is used to increase its projection. A mastoid fascial flap together with a skin graft are then used to protect the cartilage graft. All reconstructions were performed without any major complication. The results have been considered satisfactory by all patients starting from the first surgical step. Low morbidity, the good results obtained and a high rate of patient satisfaction make our protocol an optimal choice for treatment of microtia. The surgeon's experience and postoperative patient care must be considered as essential aspects of treatment. PMID:26246664

  14. 女性生殖管道发育异常225例临床分析%Clinical analysis of 225 women with congenital uterine malformation

    王世军; Mandakini Oli; 蒋励; 王建六; 魏丽惠

    2008-01-01

    目的 探讨子宫发育异常的发病情况、临床特征、诊治方法及其对生育的影响.方法 选取1990年3月-2005年1月北京大学人民医院收治的子宫发育异常患者225例的临床资料,进行回顾性分析,总结不同类型子宫发育异常的构成比、临床特征、诊治方法及对生育的影响.结果 (1)225例子宫发育异常患者中,中隔子宫125例,占55.6%,其中122例(97.6%,122/125)患者妊娠,但影响其妊娠结局,出现流产、胎位异常、早产、前置胎盘、胎膜早破等并发症.(2)双子宫51例,占22.7%(51/225);其中50例(98%,50/51)患者妊娠,对妊娠无明显影响;5例(10%,5/51)合并泌尿系统畸形.(3)残角子宫26例(11.6%,26/225),发生残角子宫妊娠4例(15%,4/26),残角子宫同侧输卵管妊娠1例(4%,1/26);2例(8%,2/26)合并泌尿系统畸形;合并不孕4例(15%,4/26).(4)双角子宫14例,占6.2%(14/225),无不孕患者,出现早产、胎膜早破等并发症;1例(7%,1/14)合并泌尿系统畸形.(5)其他类型:鞍状子宫4例(1.8%,4/225),无不孕患者;无子宫3例(1.3%,3/225),均以原发闭经就诊;单角子宫2例(0.9%,2/225),均合并不孕.结论 子宫发育异常中以中隔子宫最多见.中隔子宫、双子宫、双角子官、残角子宫、鞍状子宫对生育无明显影响,但在妊娠期可出现不同的并发症.子宫发育异常常合并泌尿系统畸形.无症状的子宫发育异常,可不予处理.%Objective To investigate the prevalence, clinical features, diagnosis, treatment and the influence on procreation of uterine malformation. Methods Totally 225 women with uterine malformation referred to our hospital from Mar 1990 to Jan 2005 were involved in this retrospective analysis.The constituent ratio, clinical feature, diagnosis, treatment and the influence on procreation were analyzed.Results (1) Among 225 cases of uterine malformation, 125 cases (55.6%) were septate uterus; 122(97.6%, 122/125 ) of these patients became pregnant, but

  15. 12 CFR 225.171 - What are the limitations on managing or operating a portfolio company held as a merchant banking...

    2010-01-01

    ... restrictions on such activities contained in §§ 225.28(b)(6) or 225.86(b)(1) of this part (12 CFR 225.28(b)(6... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What are the limitations on managing or operating a portfolio company held as a merchant banking investment? 225.171 Section 225.171 Banks...

  16. Composite outcomes in 2.25-mm drug eluting stents: a systematic review

    Background: Coronary atherosclerosis often involves small-caliber coronaries, yet the safety and efficacy of 2.25-mm DES have been poorly defined, with a general lack of separation of 2.25 with 2.5-mm performance. No randomized head-to-head 2.25 mm DES studies have been reported. There are several single-arm prospective studies, and we aim to systematically review all published specific 2.25-mm data to estimate composite DES-specific performance and highlight current knowledge gaps. Methods: We performed a systematic literature search of PubMed, EMBASE, Web of Science and Cochrane database for clinical trials of 2.25-mm DES. Angiographic and composite clinical outcomes were compared with descriptive statistics. Results: 2.25 mm-Paclitaxel (PES), sirolimus (SES), everolimus (EES) and platinum chromium EES DES-specific outcomes have been reported. Death at 12 months for SES, PES, EES and platinum chromium EES was 1.3%, 3.0%, 1.5%, and 4.4%. Rates of target vessel revascularization at 12 months for SES, PES, EES and platinum chromium EES were 5.7%, 13.3%, 8.8%, and 3.3%. Angiographic outcomes at 9 months to one year were as follows: mean late lumen loss (LLL) for SES, PES, and EES was 0.15 ± 0.11-mm, 0.28 ± 0.11-mm, and 0.16 ± 0.41-mm and mean diameter restenosis for SES, PES, and EES were 29.5 ± 6.2%, 34.7 ± 4.2%, and 20.9 ± 22.5%. Reported stent thrombosis rates for 2.25-mm DES were low ranging from 0% to 2.2% in up to 24-months of follow-up. Conclusions: This systematic review summarizes and tabulates all available specific data on 2.25-mm DES. Based on our descriptive analysis, 2.25-mm DESs have a favorable safety and efficacy profile for the treatment of very small coronary lesions. - Highlights: • Safety and efficacy of 2.25-mm DES have been poorly defined. • We performed a systematic review on all published 2.25 mm data to estimate composite DES-specific performance and highlight current knowledge gaps. • We pooled data from 9 clinical studies and 1

  17. Composite outcomes in 2.25-mm drug eluting stents: a systematic review

    Lee, Justin Z. [Department of Medicine, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ, 85724 (United States); Singh, Nirmal [Department of Cardiovascular Diseases, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States); Ortega, Gilbert [College of Medicine, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States); Low, See Wei; Kanakadandi, Uday [Department of Cardiovascular Diseases, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States); Fortuin, F. David [Department of Cardiovascular Diseases, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ, 85054 (United States); Lassar, Tom [Department of Cardiovascular Diseases, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States); Lee, Kwan S., E-mail: klee@shc.arizona.edu [Department of Cardiovascular Diseases, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States)

    2015-06-15

    Background: Coronary atherosclerosis often involves small-caliber coronaries, yet the safety and efficacy of 2.25-mm DES have been poorly defined, with a general lack of separation of 2.25 with 2.5-mm performance. No randomized head-to-head 2.25 mm DES studies have been reported. There are several single-arm prospective studies, and we aim to systematically review all published specific 2.25-mm data to estimate composite DES-specific performance and highlight current knowledge gaps. Methods: We performed a systematic literature search of PubMed, EMBASE, Web of Science and Cochrane database for clinical trials of 2.25-mm DES. Angiographic and composite clinical outcomes were compared with descriptive statistics. Results: 2.25 mm-Paclitaxel (PES), sirolimus (SES), everolimus (EES) and platinum chromium EES DES-specific outcomes have been reported. Death at 12 months for SES, PES, EES and platinum chromium EES was 1.3%, 3.0%, 1.5%, and 4.4%. Rates of target vessel revascularization at 12 months for SES, PES, EES and platinum chromium EES were 5.7%, 13.3%, 8.8%, and 3.3%. Angiographic outcomes at 9 months to one year were as follows: mean late lumen loss (LLL) for SES, PES, and EES was 0.15 ± 0.11-mm, 0.28 ± 0.11-mm, and 0.16 ± 0.41-mm and mean diameter restenosis for SES, PES, and EES were 29.5 ± 6.2%, 34.7 ± 4.2%, and 20.9 ± 22.5%. Reported stent thrombosis rates for 2.25-mm DES were low ranging from 0% to 2.2% in up to 24-months of follow-up. Conclusions: This systematic review summarizes and tabulates all available specific data on 2.25-mm DES. Based on our descriptive analysis, 2.25-mm DESs have a favorable safety and efficacy profile for the treatment of very small coronary lesions. - Highlights: • Safety and efficacy of 2.25-mm DES have been poorly defined. • We performed a systematic review on all published 2.25 mm data to estimate composite DES-specific performance and highlight current knowledge gaps. • We pooled data from 9 clinical studies and 1

  18. 21 CFR 2.25 - Grain seed treated with poisonous substances; color identification to prevent adulteration of...

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Grain seed treated with poisonous substances; color identification to prevent adulteration of human and animal food. 2.25 Section 2.25 Food and Drugs... identification to prevent adulteration of human and animal food. (a) In recent years there has...

  19. 12 CFR 225.175 - What risk management, record keeping and reporting policies are required to make merchant banking...

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What risk management, record keeping and reporting policies are required to make merchant banking investments? 225.175 Section 225.175 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK...

  20. 12 CFR 225.104 - “Services” under section 4(c)(1) of Bank Holding Company Act.

    2010-01-01

    ... company chooses to have done through another organization. Moreover, the report of the Senate Banking and... Holding Company Act. 225.104 Section 225.104 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF... Holding Company Act. (a) Section 4(c)(1) of the Bank Holding Company Act, among other things, exempts...

  1. 34 CFR 225.11 - What selection criteria does the Secretary use in evaluating an application for a Credit...

    2010-07-01

    ... evaluating an application for a Credit Enhancement for Charter School Facilities grant? 225.11 Section 225.11... application for a Credit Enhancement for Charter School Facilities grant? The Secretary uses the following criteria to evaluate an application for a Credit Enhancement for Charter School Facilities grant:...

  2. 12 CFR 225.111 - Limit on investment by bank holding company system in stock of small business investment companies.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Limit on investment by bank holding company system in stock of small business investment companies. 225.111 Section 225.111 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES...

  3. 12 CFR 225.103 - Bank holding company acquiring stock by dividends, stock splits or exercise of rights.

    2010-01-01

    ... dividends, stock splits or exercise of rights. 225.103 Section 225.103 Banks and Banking FEDERAL RESERVE... holding company acquiring stock by dividends, stock splits or exercise of rights. (a) The Board of... bank stock splits without the Board's prior approval, and whether such a company may exercise,...

  4. 12 CFR 225.122 - Bank holding company ownership of mortgage companies.

    2010-01-01

    ... “incidental powers” clause. (See 1966 Federal Reserve Bulletin 1151; 12 CFR 208.119.) Accordingly, a bank... the 1958 Federal Reserve Bulletin at page 431 (12 CFR 225.104), the legislative history of the... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Bank holding company ownership of...

  5. First Measurement of the Permanent Electric Dipole Moment of Radium-225

    Singh, Jaideep T.; Bailey, K. G.; Bishof, M. N.; Dietrich, M. R.; Greene, J. P.; Holt, R. J.; Kalita, M. R.; Korsch, W.; Lemke, N. D.; Lu, Z.-T.; Mueller, P.; O'Connor, T. P.; Parker, R. H.

    2015-04-01

    Electric dipole moments (EDMs) are signatures of time-reversal (T), parity (P),& charge-parity (CP) violation. CP -violation beyond the Standard Model is generally believed to be required to explain the observed prevalence of matter over antimatter in the universe. Radium-225 (τ1 / 2 = 14 . 7 d, I = 1 / 2) is mostly sensitive to T- and P-violating interactions originating within the nucleus. The best limits on these types of exotic interactions are derived from the atomic EDM limit for Mercury-199. Because of its unusual nuclear structure (octupole deformation), Ra-225 is expected to have a physics sensitivity that is a few hundred to a few thousand times higher than Hg-199. Laser cooling & trapping techniques are performed to collect & transport the cold Ra atoms into the measurement region. An EDM measurement is then performed by searching for a linear electric field dependent shift in the nuclear spin precession frequency of Ra-225. We will report on the first measurement of the atomic EDM of Ra-225 as well as plans for future improvements. This work is supported by U.S. DOE, Office of Science, Office of Nuclear Physics, under Contract DE-AC02-06CH11357.

  6. 2 CFR Appendix B to Part 225 - Selected Items of Cost

    2010-01-01

    ... Part 225—Selected Items of Cost Table of Contents 1. Advertising and public relations costs 2. Advisory... related items of cost. 1. Advertising and public relations costs. a. The term advertising costs means the..., sections E. (“Direct Costs”) and F. (“Indirect Costs”) are observed. f. Unallowable advertising and...

  7. CCD UBV Photometry and Kinematics of the Open Cluster NGC 225

    Bilir, S; Yontan, T; Guver, T; Bakis, V; Ak, T; Ak, S; Paunzen, E; Eker, Z

    2016-01-01

    We present the results of CCD $UBV$ photometric and spectroscopic observations of the open cluster NGC 225. In order to determine the structural parameters of NGC 225, we calculated the stellar density profile in the cluster's field. We estimated the probabilities of the stars being physical members of the cluster using the existing astrometric data. The most likely members of the cluster were used in the determination of the astrophysical parameters of the cluster. We calculated the mean radial velocity of the cluster as $V_{r}=-8.3\\pm 5.0$ km s$^{-1}$ from the optical spectra of eight stars in the cluster's field. Using the U-B vs B-V two-colour diagram and UV excesses of the F-G type main-sequence stars, the reddening and metallicity of NGC 225 were inferred as $E(B-V)=0.151\\pm 0.047$ mag and $[Fe/H]=-0.11\\pm 0.01$ dex, respectively. We fitted the colour-magnitude diagrams of NGC 225 with the PARSEC isochrones and derived the distance modulus, distance and age of the cluster as $\\mu_{V}=9.3\\pm 0.07$ mag, d...

  8. 12 CFR 225.43 - Procedures for filing, processing, publishing, and acting on notices.

    2010-01-01

    ... paragraph shall be in accordance with the Rules of Practice for Formal Hearings (12 CFR part 263). At the... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Procedures for filing, processing, publishing... (REGULATION Y) Regulations Change in Bank Control § 225.43 Procedures for filing, processing, publishing,...

  9. 78 FR 38093 - Thirteenth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

    2013-06-25

    ... Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is issuing this notice to advise the public of the twelfth meeting of the RTCA Special Committee 225, Rechargeable Lithium...

  10. 78 FR 16031 - Twelfth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

    2013-03-13

    ... Federal Aviation Administration Twelfth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is issuing this notice...

  11. 78 FR 6845 - Eleventh Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

    2013-01-31

    ... Federal Aviation Administration Eleventh Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is issuing this notice...

  12. 77 FR 39321 - Eighth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

    2012-07-02

    ... Federal Aviation Administration Eighth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Sizes AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Sizes. SUMMARY: The FAA is issuing this notice...

  13. 48 CFR 225.872-7 - Industrial security for qualifying countries.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Industrial security for... Agreements and Coordination 225.872-7 Industrial security for qualifying countries. The required procedures... qualifying country sources are in the DoD Industrial Security Regulation DoD 5220.22-R (implemented for...

  14. 77 FR 8325 - Sixth Meeting: RTCA Special Committee 225, Rechargeable Lithium Batteries and Battery Systems...

    2012-02-14

    ... Batteries and Battery Systems, Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Batteries and Battery Systems, Small and Medium Size. SUMMARY: The FAA is issuing this notice to advise the public of the sixth meeting of RTCA Special Committee 225, Rechargeable Lithium Batteries and...

  15. 77 FR 20688 - Seventh Meeting: RTCA Special Committee 225, Rechargeable Lithium Batteries and Battery Systems...

    2012-04-05

    ... Batteries and Battery Systems, Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Batteries and Battery Systems, Small and Medium Size. SUMMARY: The FAA is issuing this notice to advise the public of the seventh meeting of RTCA Special Committee 225, Rechargeable Lithium Batteries and...

  16. 48 CFR 225.7006-4 - Solicitation provision and contract clause.

    2010-10-01

    ... and contract clause. (a) Use the provision at 252.225-7037, Evaluation of Offers for Air Circuit Breakers, in solicitations requiring air circuit breakers for naval vessels unless— (1) An exception... Breakers, in solicitations and contracts requiring air circuit breakers for naval vessels unless— (1)...

  17. 47 CFR 25.225 - Geographic Service Requirements for 17/24 GHz Broadcasting Satellite Service.

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Geographic Service Requirements for 17/24 GHz... (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Technical Standards § 25.225 Geographic Service Requirements for 17/24 GHz Broadcasting Satellite Service. (a) Each operator of a 17/24 GHz BSS space...

  18. Determination of ''226Ra by Alpha Spectrometry by Using ''225Ra as Yield Tracer

    A method for the determination of low-level ''226 Ra in environmental and geological samples by alpha spectrometry is described. The method is based on the use of ''225 Ra from ''229 Th as yield tracer and has been developed to analyze U, Th and Ra in the same sample. (Author) 12 refs

  19. 20 CFR 405.225 - Notice of the Federal reviewing official's decision.

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Notice of the Federal reviewing official's... PROCESS FOR ADJUDICATING INITIAL DISABILITY CLAIMS Review of Initial Determinations by a Federal Reviewing Official § 405.225 Notice of the Federal reviewing official's decision. We will mail a written notice...

  20. 25 CFR 225.35 - Inspection of premises; books and accounts.

    2010-04-01

    ... records pertaining to a minerals agreement shall be maintained by an operator in accordance with 30 CFR... 25 Indians 1 2010-04-01 2010-04-01 false Inspection of premises; books and accounts. 225.35...; books and accounts. (a) Operators shall allow Indian mineral owners, their authorized...

  1. 48 CFR 225.7303-3 - Government-to-government agreements.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government-to-government... Military Sales 225.7303-3 Government-to-government agreements. If a government-to-government agreement between the United States and a foreign government for the sale, coproduction, or cooperative...

  2. 12 CFR 225.143 - Policy statement on nonvoting equity investments by bank holding companies.

    2010-01-01

    ... agreement placing long-term restrictions on the rights of a holder of voting securities. (12 CFR 225.2(b)(4... their investments, prevent takeovers by others, and allow for sale of their options, warrants, or rights... distribution in the event of sale, have a much greater prospect of achieving consistency with the Act...

  3. A=225 implantation for $^{221}$Fr source for TRIUMF atom trap

    The FrPNC Collaboration is mounting an atom trap for parity violation experiments and precision spectroscopy on francium atoms at TRIUMF's ISAC facility. We would like to use ISOLDE's capability of simultaneously implanting A=225 (while another experiment runs online) to make a long-lived source feeding $^{221}$Fr for tests of the trap. $^{225}$Ra $\\beta$-decays to $^{225}$Ac, which then $\\alpha$-decays, producing 100 keV $^{221}$Fr t$_{1/2}$= 4.8 minute recoils. The implanted A=225 source would be shipped to TRIUMF, where it would be held for several minutes at a time a few mm from the same yttrium foil that normally receives the ISAC beam. SRIM calculations imply that 20% of the $^{221}$Fr will be implanted in a 1 cm diameter spot on the yttrium. Then the yttrium foil is moved to the trap and heated to release the Fr atoms, just as in normal ISAC online operation. A test implantation will be done at 10$^{7}$/sec production for 1 day, testing whether carbon cracking on the implantation foil in the mass separ...

  4. 27 CFR 70.225 - Suspension of running of period of limitation; assets of taxpayer in control or custody of court.

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Suspension of running of period of limitation; assets of taxpayer in control or custody of court. 70.225 Section 70.225 Alcohol... (Occupational) Tax Limitations § 70.225 Suspension of running of period of limitation; assets of taxpayer...

  5. The E2-25K ubiquitin-associated (UBA) domain aids in polyubiquitin chain synthesis and linkage specificity

    Research highlights: → We examine the role of a ubiquitin-associated (UBA) domain in an E2 enzyme. → The E2-25K UBA domain directs polyubiquitin chain linkage specificity. → The E2-25K UBA domain regulates length of polyubiquitin chains synthesized. -- Abstract: E2-25K is an ubiquitin-conjugating enzyme with the ability to synthesize Lys48-linked polyubiquitin chains. E2-25K and its homologs represent the only known E2 enzymes which contain a C-terminal ubiquitin-associated (UBA) domain as well as the conserved catalytic ubiquitin-conjugating (UBC) domain. As an additional non-covalent binding surface for ubiquitin, the UBA domain must provide some functional specialization. We mapped the protein-protein interface involved in the E2-25K UBA/ubiquitin complex by solution nuclear magnetic resonance (NMR) spectroscopy and subsequently modeled the structure of the complex. Domain-domain interactions between the E2-25K catalytic UBC domain and the UBA domain do not induce significant structural changes in the UBA domain or alter the affinity of the UBA domain for ubiquitin. We determined that one of the roles of the C-terminal UBA domain, in the context of E2-25K, is to increase processivity in Lys48-linked polyubiquitin chain synthesis, possibly through increased binding to the ubiquitinated substrate. Additionally, we see evidence that the UBA domain directs specificity in polyubiquitin chain linkage.

  6. Immunoscintigraphy with anti-225.28S for ocular melanoma - a comparison with histology and immunohistochemistry

    Aim: The purpose of this prospective study was to evaluate the value of immunoscintigraphy (ISG) with anti-225.28S in clinically suspected ocular melanoma. Methods: For this purpose standardized ISG was performed in 36 patients using both planar acquisition and emission computed tomography (ECT). Ocular melanoma was present in 31 patients. In 21 patients therapy was enucleation of the eye. These specimens were evaluated by histology and immunohistochemistry in 11 of 21 patients. Results: Regarding the clinical diagnosis, ISG was positive only in 15 of 31 patients with ocular melanoma, regarding histology in 11 of 21 and regarding immunohistochemistry in 5 of 6 patients with a positive immunoreaction. 5 patients showed no immunoreactivity, their ISG was negative. Conclusion: Thus a good correlation between ISG and immunohistochemistry was observed. However ISG using the cutaneous melanoma antibody 225.28S cannot be recommended for the diagnostic work-up of an ocular melanoma considering the poor immunoreactivity. (orig.)

  7. Elastic scattering of neutron from 40Ca at 65-225 MeV

    We show the radial behavior of real part and imaginary part of the calculated central optical potential for n - 40Ca elastic scattering at incident energies En = 65, 75, 85, 95, 107.5, 127.5, 155, 185, 225 MeV using Urbana V-14 and Hamada Johnston realistic interaction. In the present work, we have analyzed neutron elastic scattering data at 65, 75, 85, 107.5, 127.5, 155, 185, 225 MeV from 40Ca using optical model potential calculated in first order Brueckner theory from two sources. We have used Urbana V-14 soft core inter nucleon potential as well as hard core Hamada Johnston inter- nucleon potential. We denote the neutron-nucleus optical potential obtained using soft-core potential by V-14 and for the hard-core potential by HJ

  8. Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K.

    Helms, Kimberli M; Wilson, Randall C; Ogungbe, Ifedayo V; Setzer, William N; Twigg, Pamela D

    2011-10-01

    An extract of bark from the tropical rainforest plant Byrsonima crassifolia was screened for inhibition of diubiquitin formation by the human ubiquitin-conjugating enzyme E2-25K. Activity assays with both the full-length enzyme and a truncated, active catalytic UBC domain revealed that the extract contained inhibitory properties. Separation of the extract into individual components and additional screens identified vitexin as the active inhibitor. An IC50 for vitexin was calculated to be approximately 0.5 mM. Molecular modeling simulations were used to predict the mode of inhibition and NMR spectra were used to confirm the binding site of vitexin to E2-25K. PMID:22164771

  9. 内地50家企业入选2009年ENR225

    2009-01-01

    2009年9月5日,美国麦格劳·希尔建筑信息公司(McGraw—Hill)在其官方网站发布了2009年度ENR全球最大225家国际承包商排名,我国内地共有50家企业榜上有名。ENR的统计显示,全球225家最大国际承包商的海外经营业绩在2008年大幅飙升,完成海外营业额较上年度增长了25.7%。

  10. Structure of quinoprotein methylamine dehydrogenase at 2.25 A resolution.

    Vellieux, F. M.; Huitema, F; Groendijk, H; Kalk, K H; Jzn, J F; Jongejan, J.A.; Duine, J A; Petratos, K; DRENTH, J.; Hol, W. G.

    1989-01-01

    The three-dimensional structure of quinoprotein methylamine dehydrogenase from Thiobacillus versutus has been determined at 2.25 A resolution by a combination of multiple isomorphous replacement, phase extension by solvent flattening and partial structure phasing using molecular dynamics refinement. In the resulting map, the polypeptide chain for both subunits could be followed and an X-ray sequence was established. The tetrameric enzyme, made up of two heavy (H) and two light (L) subunits, i...

  11. Atmospheric Abundances, Trends and Emissions of CFC-216ba, CFC-216ca and HCFC-225ca

    Corinna Kloss

    2014-06-01

    Full Text Available The first observations of the feedstocks, CFC-216ba (1,2-dichlorohexafluoropropane and CFC-216ca (1,3-dichlorohexafluoropropane, as well as the CFC substitute HCFC-225ca (3,3-dichloro-1,1,1,2,2-pentafluoropropane, are reported in air samples collected between 1978 and 2012 at Cape Grim, Tasmania. Present day (2012 mixing ratios are 37.8 ± 0.08 ppq (parts per quadrillion; 1015 and 20.2 ± 0.3 ppq for CFC-216ba and CFC-216ca, respectively. The abundance of CFC-216ba has been approximately constant for the past 20 years, whilst that of CFC-216ca is increasing, at a current rate of 0.2 ppq/year. Upper tropospheric air samples collected in 2013 suggest a further continuation of this trend. Inferred annual emissions peaked 421 at 0.18 Gg/year (CFC-216ba and 0.05 Gg/year (CFC-216ca in the mid-1980s and then decreased sharply as expected from the Montreal Protocol phase-out schedule for CFCs. The atmospheric trend of CFC-216ca and CFC-216ba translates into continuing emissions of around 0.01 Gg/year in 2011, indicating that significant banks still exist or that they are still being used. HCFC-225ca was not detected in air samples collected before 1992. The highest mixing ratio of 52 ± 1 ppq was observed in 2001. Increasing annual emissions were found in the 1990s (i.e., when HCFC-225ca was being introduced as a replacement for CFCs. Emissions peaked around 1999 at about 1.51 Gg/year. In accordance with the Montreal Protocol, restrictions on HCFC consumption and the short lifetime of HCFC-225ca, mixing ratios declined after 2001 to 23.3 ± 0.7 ppq by 2012.

  12. Which Option Pricing Model is the Best? High Frequency Data for Nikkei225 Index Options

    Ryszard Kokoszczyński; Paweł Sakowski; Robert Ślepaczuk

    2010-01-01

    Option pricing models are the main subject of many research papers prepared both in academia and financial industry. Using high-frequency data for Nikkei225 index options, we check the properties of option pricing models with different assumptions concerning the volatility process (historical, realized, implied, stochastic or based on GARCH model). In order to relax the continuous dividend payout assumption, we use the Black model for pricing options on futures, instead of the Black-Scholes-M...

  13. Cavity Formation in Aluminium Irradiated with a Pulsating Beam of 225 MeV Electrons

    Singh, Bachu Narain; Bilde-Sørensen, Jørgen; Leffers, Torben;

    1984-01-01

    High-purity aluminium was irradiated with a pulsating beam of 225 MeV electrons to a maximum dose of 0.035 dpa with a helium generation rate of up to 17 appm/dpa. The irradiated samples contained cavities in the size range 5 to 70 nm. In a zone of up to 14 μm from the grain boundaries cavity size...

  14. Wind turbine test Vestas V27-225 kW

    Markkilde Petersen, S.

    1990-10-15

    The report describes fundamental measurements performed on a Vestas-V27-225 kW pitch regulated wind turbine. The measurements carried out and reported here comprises the power output, system efficiency, energy production, transmission efficiency, rotor power, rotor efficiency, air-brakes efficiency, structural dynamics, loads at cut-in and braking, yaw error statistics, flapwise root bending moment and rotor thrust. (author).

  15. Structure of liquid heavy water from 20 deg.C to 225 deg.C

    Recent results concerning the investigation of microscopic water properties by means of time of flight neutron diffraction are presented. It is found that the mean distance among water molecules increases with the decrease of water temperature. This implies an increase in local fourfold coordination due to the increase in 'hydrogen bonds'. Such behavior is observed in time-of-flight diffraction experiments using constant volume measurements for temperature range from +20 deg.C to 225 deg.C. (authors)

  16. Interplay of fission modes in mass distribution of light actinide nuclei 225,227Pa

    R. Dubey

    2016-01-01

    Full Text Available Fission-fragment mass distributions were measured for 225,227Pa nuclei formed in fusion reactions of 19F+206,208Pb around fusion barrier energies. Mass-angle correlations do not indicate any quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with existing data for induced fission of 224,226Th and 228U around barrier energies. Enhancement in mass variance of 225,227Pa nuclei at below-barrier energies shows evidence for presence of asymmetric fission events mixed with symmetric fission events. This is in agreement with the results of mass distributions of nearby nuclei 224,226Th and 228U where two-mode fission process was observed. Two-mode feature of fission arises due to the shell effects changing the landscape of the potential-energy surfaces at low excitation energies. The excitation-energy dependence of the mass variance gives strong evidence for survival of microscopic shell effects in fission of light actinide nuclei 225,227Pa with initial excitation energy ∼30–50 MeV.

  17. Interplay of fission modes in mass distribution of light actinide nuclei 225,227Pa

    Dubey, R.; Sugathan, P.; Jhingan, A.; Kaur, Gurpreet; Mukul, Ish; Mohanto, G.; Siwal, D.; Saneesh, N.; Banerjee, T.; Thakur, Meenu; Mahajan, Ruchi; Kumar, N.; Chatterjee, M. B.

    2016-01-01

    Fission-fragment mass distributions were measured for 225,227Pa nuclei formed in fusion reactions of 19F + 206,208Pb around fusion barrier energies. Mass-angle correlations do not indicate any quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with existing data for induced fission of 224,226Th and 228U around barrier energies. Enhancement in mass variance of 225,227Pa nuclei at below-barrier energies shows evidence for presence of asymmetric fission events mixed with symmetric fission events. This is in agreement with the results of mass distributions of nearby nuclei 224,226Th and 228U where two-mode fission process was observed. Two-mode feature of fission arises due to the shell effects changing the landscape of the potential-energy surfaces at low excitation energies. The excitation-energy dependence of the mass variance gives strong evidence for survival of microscopic shell effects in fission of light actinide nuclei 225,227Pa with initial excitation energy ∼30-50 MeV.

  18. Guidance and considerations for implementation of INFCIRC/225/Rev.3, the physical protection of nuclear material

    The Physical Protection of Nuclear Material, INFCIRC/225/Rev.3, provides recommendations for the physical protection of nuclear material against theft in use, storage and transport, whether national or international and whether peaceful or military, and contains provisions relating to the sabotage of nuclear material or facilities. The recommendations contained in INFCIRC/225/Rev.3 detail the elements that should be included in a State's system of physical protection. It also recognizes the adverse health and safety consequences arising from the theft of nuclear material and the sabotage of nuclear material or facilities. Most industrial and developing countries use these recommendations to some extent in the establishment and operation of their physical protection systems. Although INFCIRC/225/Rev.3 provides recommendations for protecting materials and facilities from theft or sabotage, it does not provide in-depth details for these recommendations. In June 1996, the IAEA convened a consultants meeting to consider this matter. This report is the result of continuing discussions and drafts over a period of nine months. The intent of this guidance is to provide a broader basis for relevant State organizations to prescribe appropriate requirements for the use of nuclear materials which are compatible with accepted international practice

  19. NOAA TIFF Image- 5m Bathymetry (Sun Illuminated- Azimuth 225) of St. Croix (Buck Island), US Virgin Islands, 2004

    National Oceanic and Atmospheric Administration, Department of Commerce — This georeferenced image represents 5 meter resolution bathymetry (sun illuminated with azimuth 225 and incline 45) of the north shore of St. Croix, US Virgin...

  20. Development of a Complex Geometry Standard Fixture and Solvent Evaluation Method fo Assessing Replacement Solvents for AK-225G Project

    National Aeronautics and Space Administration — The focus of this analysis was the development of a complex geometry test fixture and test method for determining solvent cleaning efficiency. AK-225 belongs to a...

  1. "Modeling and Forecasting the Volatility of the Nikkei 225 Realized Volatility Using the ARFIMA-GARCH Model"

    Isao Ishida; Toshiaki Watanabe

    2009-01-01

    In this paper, we apply the ARFIMA-GARCH model to the realized volatility and the continuous sample path variations constructed from high-frequency Nikkei 225 data. While the homoskedastic ARFIMA model performs excellently in predicting the Nikkei 225 realized volatility time series and their square-root and log transformations, the residuals of the model suggest presence of strong conditional heteroskedasticity similar to the finding of Corsi et al. (2007) for the realized S&P 500 futures vo...

  2. Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity

    Background and purpose: Inhibition of EGFR-function can induce radiosensitization in tumor cells. Purpose of our investigation was to identify the possible molecular mechanism of radiosensitization following treatment with anti-EGFR-antibody C225 (Cetuximab). Materials and methods: The effect of C225 on radiation response was determined in human cell lines of bronchial carcinoma (A549) and breast adenoma cells (MDA MB 231). The molecular effects of C225 on EGFR-function after irradiation were analyzed applying western blotting, immune-precipitation and kinase assays. Effects on DNA-repair were detected by quantification of γ-H2AX positive foci 24 h after irradiation. Results: The EGFR specific antibody C225 induced radiosensitization in A549 and also in MDA MB 231 cells. Radiosensitization in A549 was associated with blockage of radiation-induced EGFR transport into the nucleus, and immobilized the complex of EGFR with DNA-dependent protein kinase (DNA-PK) in the cytoplasm. As a consequence radiation-induced DNA-PK activation was abolished, a process that is essential for DNA-repair after radiation exposure. Likewise C225 treatment increased the residual amount of γ-H2AX-positive foci 24 h after irradiation in A549 and in MDA MB 231 cells. Conclusions: Our results suggest that irradiation induced DNA-PK activation-essential for DNA repair-may be hampered specifically by use of the anti-EGFR-antibody C225. This process is associated with radiosensitization

  3. Treatment of pancreatic cancer xenografts with Erbitux (IMC-C225) anti-EGFR antibody, gemcitabine, and radiation

    Purpose: To investigate treatment of human pancreatic cancer cell lines and xenografts with combinations of Erbitux (IMC-C225) anti-epidermal growth factor receptor (EGFR) antibody, gemcitabine, and radiation. Methods and Materials: BxPC-3 and MiaPaCa-2 human pancreatic carcinoma cells were treated in vitro for 24 h with IMC-C225 (5 μg/mL), then exposed to epidermal growth factor (EGF) (10 mM) for 5 min. Immunoblots were screened for EGFR expression and the ability of IMC-C225 to block EGF-induced tyrosine phosphorylation of EGFR. Cells were treated with IMC-C225 (5 μg/mL) on Day 0, the IC50 dose of gemcitabine on Day 1 for 24 h, followed by 3 Gy 60Co irradiation on Day 2, or the combination of each agent. For cell proliferation, cells were counted on Day 4, and for apoptosis, cells were stained with annexin V-FITC and propidium iodide, then analyzed by FACS. Cells were treated with the same single or multiple treatments and analyzed in a clonogenic cell survival assay. The effect of IMC-C225, gemcitabine, and radiation on the growth of BxPC-3 and MiaPaCa-2 tumor xenografts was determined. Athymic nude mice bearing established s.c. tumor xenografts of 6-8 mm diameter received 6 weeks of treatment with IMC-C225 (1 mg every 3 days x 6) alone or in combination with gemcitabine (120 mg/kg i.v. every 6 days x 6), and 6 weekly fractions of 3 Gy radiation on the days after gemcitabine administration. Tumor growth was measured with Vernier calipers. Results: BxPC-3 and MiaPaCa-2 cell lines expressed low levels of EGFR. IMC-C225 inhibited EGF-induced tyrosine phosphorylation of the EGF receptor on both cell lines. Treatment of cells with a combination of IMC-C225 + gemcitabine + radiation produced the highest induction of apoptosis and inhibition of proliferation in vitro. Combination treatment with IMC-C225, gemcitabine, and radiation produced 100% complete regression of MiaPaCa-2 tumors for more than 250 days, and the greatest growth inhibition of BxPC-3 tumors compared

  4. Interplay of fission modes in mass distribution of light actinide nuclei 225,227Pa

    R Dubey; Sugathan, P; Jhingan, A.; Gurpreet Kaur; Ish Mukul; G. Mohanto; Siwal, D.; Saneesh, N.; T Banerjee; Meenu Thakur; Ruchi Mahajan; Kumar, N; Chatterjee, M. B.

    2016-01-01

    Fission-fragment mass distributions were measured for 225,227 Pa nuclei formed in fusion reactions of 19 F + 206,208 Pb around fusion barrier energies. Mass-angle correlations do not indicate any quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with exis...

  5. Time history solution program, L225 (TEV126). Volume 1: Engineering and usage

    Kroll, R. I.; Tornallyay, A.; Clemmons, R. E.

    1979-01-01

    Volume 1 of a two volume document is presented. The usage of the convolution program L225 (TEV 126) is described. The program calculates the time response of a linear system by convoluting the impulsive response function with the time-dependent excitation function. The convolution is performed as a multiplication in the frequency domain. Fast Fourier transform techniques are used to transform the product back into the time domain to obtain response time histories. A brief description of the analysis used is presented.

  6. Production of chi mesons in 225 GeV/c π-Be interactions

    Gamma rays associated with psi mesons have been studied in 225 GeV/c π-Be interactions. The psi-γ mass spectrum shows an excess of 47 +- 11 events above background centered at 3.531 GeV/c2 with an rms width of 22.4 MeV. Attributing this excess of events to the decay chi → psi γ implies that 38 +- 9 % of all psi mesons are produced by this mechanism. The experimental setup and results are detailed

  7. Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles.

    Wang, G; de Kruijff, R M; Rol, A; Thijssen, L; Mendes, E; Morgenstern, A; Bruchertseifer, F; Stuart, M C A; Wolterbeek, H T; Denkova, A G

    2014-02-01

    Alpha radionuclide therapy is steadily gaining importance and a large number of pre-clinical and clinical studies have been carried out. However, due to the recoil effects the daughter recoil atoms, most of which are alpha emitters as well, receive energies that are much higher than the energies of chemical bonds resulting in decoupling of the radionuclide from common targeting agents. Here, we demonstrate that polymer vesicles (i.e. polymersomes) can retain recoiling daughter nuclei based on an experimental study examining the retention of (221)Fr and (213)Bi when encapsulating (225)Ac. PMID:24374072

  8. 22.5% efficient silicon heterojunction solar cell with molybdenum oxide hole collector

    Substituting the doped amorphous silicon films at the front of silicon heterojunction solar cells with wide-bandgap transition metal oxides can mitigate parasitic light absorption losses. This was recently proven by replacing p-type amorphous silicon with molybdenum oxide films. In this article, we evidence that annealing above 130 °C—often needed for the curing of printed metal contacts—detrimentally impacts hole collection of such devices. We circumvent this issue by using electrodeposited copper front metallization and demonstrate a silicon heterojunction solar cell with molybdenum oxide hole collector, featuring a fill factor value higher than 80% and certified energy conversion efficiency of 22.5%

  9. An 225Ac/213Bi generator system for therapeutic clinical applications: construction and operation

    A method for construction and operation of an 225Ac/213Bi generator capable of producing 25-100 mCi of 213Bi suitable for clinical antibody labeling is described. The generator has been designed to have an effective lifetime of several weeks, producing up to six therapeutic doses of radionuclide per day. To date, 57 clinical doses have been prepared and injected into patients using the described 213Bi generator. Factors such as radiation damage, radioprotection, iodide eluate chemistry, radiolabeling chemistry and radionuclidic purity are addressed

  10. Laser-trapping of Ra-225 and Ra-226 with repumping by room temperature blackbody radiation

    Guest, J R; Scielzo, N. D.; Ahmad, I.; Bailey, K.; Greene, J. P.; Holt, R J; Lu, Z. -T.; O'Connor, T. P.; Potterveld, D. H.

    2007-01-01

    We have demonstrated Zeeman slowing and capture of neutral Ra-225 and Ra-226 atoms in a magneto-optical trap (MOT). The intercombination transition 1S0-3P1 is the only quasi-cycling transition in radium and was used for laser-cooling and trapping. Repumping along the 3D1-1P1 transition extended the lifetime of the trap from milliseconds to seconds. Room-temperature blackbody radiation was demonstrated to provide repumping from the metastable 3P0 level. We measured the isotope shift and hyperf...

  11. Facile solvent extraction separation of Th-227 and Ac-225 based on room-temperature ionic liquids

    New separation methodologies for radioisotopes are crucial to many medical applications. In this work, the solvent extraction of Th-227 and Ac-225 based on ionic liquids (ILs) was investigated using N,N,N',N'-tetraoctyldiglycolamide (TODGA) or di(2-ethylhexyl)phosphoric acid (HDEHP) as an extractant. Four ILs, 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([C4mim][NTf2]), 1-butyl-3-methylimidazolium bis(perfluoroethanesulfonyl)imide ([C4mim][BETI]), 1-butyl-2,3-trimethyleneimidazolium (trifluoromethanesulfonyl)imide ([BuI5][NTf2]), and 1-benzyl pyridinium bis(trifluoromethanesulfonyl)imide ([PhCH2Py][NTf2]) with different cation or anion structural features were used as diluents for the separation of Th-227 and Ac-225. Excellent extraction efficiencies and selectivities were found for Th-227/Ac-225 when HDEHP was used as an extractant in these ILs. The effects of different extractant concentrations in ILs and different aqueous phase acidities on extraction efficiencies and selectivities of Th-227/Ac-225 are also presented. The success in separation of Th-227 and Ac-225 isotopes highlights great potentials of use of ionic liquids in isotope production. (orig.)

  12. Specific targeting of nasopharyngeal carcinoma cell line CNE1 by C225-conjugated ultrasmall superparamagnetic iron oxide particles with magnetic resonance imaging

    Dongbo Lin; Chunli Chen; Guangyuaa Hu; Qi Mei; Hong Qiu; Guoxian Long; Guoqing Hu

    2011-01-01

    An accurate definition of clinical target volume (CTV) is essential for the application of radiotherapy in nasopharvngeai carcinoma (NPC) treatment. A novel epidermal growth factor receptor (EGFR)-targeting contrast agent (C225-USPIO) was designed by conjugating ultrasmail superparamagnetic iron oxide (USPIO) nanoparticles with cetuximab (C225), to non-invasively define the CTV of tumor. The immunobinding activity of C225-USPIO to NPC cell line CNEI was confirmed by flow cytometry and immunofluorescence. The time-dependent accumulation of C225-USPIO in CNE1 cells was evaluated using Prussian blue staining. Targeted internalization and subcellular localization of C225-USPIO was confirmed by transmission electron microscope. The results indicated that C225-USPIO specifically bound to EGFR on the surface of CNEI cells and was taken up into the cell. The uptake of C225-USPIO by CNE1 cells increased significantly with time, when compared with human IgG-USPIO. In addition, 4.7 T magnetic resonance imaging (MRI) revealed that C225-USPIO had a capacity to accumulate in the CNE1 cells, with a resultant marked decrease in MRI T2-weighted signal intensity over time. These findings imply that C225-USPIO has the potential as an MRI contrast agent and can be employed to non-invasively detect early-stage NPC with EGFR overexpression. This provides sufficient theoretical basis for commencing in vivo experiments with the compound.

  13. Interplay of fission modes in mass distribution of light actinide nuclei 225,227Pa

    Dubey, R; Jhingan, A; Kaur, Gurpreet; Mukul, Ish; Mohanto, G; Siwal, D; Saneesh, N; Banerjee, T; Thakur, Meenu; Mahajan, Ruchi; Kumar, N; Chatterjee, M B

    2015-01-01

    Fission-fragment mass distributions were measured for 225,227Pa nuclei formed in fusion reactions of 19F + 206, 208Pb around fusion barrier energies. Mass-angle correlations do not indicate any quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with existing data for induced fission of 224, 226Th and 228U around barrier energies. Enhancement in mass variance of 225, 227Pa nuclei at below-barrier energies shows evidence for presence of asymmetric fission events mixed with symmetric fission events. This is in agreement with the results of mass distributions of nearby nuclei 224, 226Th and 228U where two-mode fission process was observed. Two-mode feature of fission arises due to the shell effects changing the landscape of the potential energy surfaces at low excitation energ...

  14. Challenges and opportunities in the search for electric dipole moment (EDM) in 225Ra atom

    Kalita, Mukut; Bailey, Kevin; Dietrich, Matthew; Greene, John; Holt, Roy; Korsch, Wolfgang; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas; Parker, Richard; Sulai, Ibrahim; Singh, Jaideep

    2011-10-01

    The observation of a permanent electric dipole moment (EDM) in a non-degenerate system would indicate violation of time reversal symmetry. 225Ra atom is a particularly attractive candidate for this search since it has a nuclear spin I = 1/2 and has a significant nuclear octupole deformation. This property increases the Schiff moment of the nucleus and therefore enhances the atomic EDM. The half life (t1/2 = 14.9 days) of 225Ra is sufficiently long to perform EDM searches. Our group has already demonstrated the trapping of laser cooled Ra atoms in a magneto-optical trap (MOT) and transferring them to a far off resonant optical dipole trap (ODT). We will discuss our recent progress on manipulation of ultra cold Ra atoms in the ODT, efforts in improving our laser systems and generation of electric and magnetic fields required for the measurement. This work is supported by DOE, Office of Nuclear Physics, under contract No. DE-AC02-06CH11357 and contract No. DE-FG02-99ER41101.

  15. Transport properties of icosahedral Al70Pd22.5Re7.5 quasicrystals

    We report the electrical and thermal transport properties, including electric resistivity (ρ), Seebeck coefficient (S) and thermal conductivity (κ) of icosahedral Al70Pd22.5Re7.5 quasicrystals in the temperature range between 10 and 300 K. Four Al70Pd22.5Re7.5 samples with a resistivity ratio R = ρ4.2K/ρ300K ranging from 10.2 to 84.4 were studied. The temperature-dependent resistivities increase with decreasing temperature for all samples, exhibiting a semiconductor-like behaviour. The Seebeck coefficients are positive for the large-R samples (R 26.3 and 84.4) in the entire temperature range, while S-values become negative for the small-R samples (R = 10.2 and 19.4) below about 120 K. The significant dependence on R of the Seebeck coefficient can be qualitatively understood in the pseudogap scenario. The temperature variation of the thermal conductivity for these materials is quite similar, with values less than 2.5 Wm-1K-1 in the temperature range we investigated. The dimensionless thermoelectric figure of merit (ZT) of this system is estimated to be two orders of magnitude smaller than that of conventional thermoelectric materials

  16. Development of Cr3C2-25(Ni20Cr) nanostructured coatings

    This study is divided in two parts. The first part is about the preparation of nanostructured Cr3C2-25(Ni20Cr) powders by high energy milling followed by characterization of the milled and the as received powder. Analyses of some of the data obtained were done using a theoretical approach. The second part of this study is about the preparation and characterization of coatings prepared with the nanostructured as well as the as received Cr3C2-25(Ni20Cr) powders. The high temperature erosion-oxidation (E-O) behavior of the coatings prepared with the two types of powders has been compared based on a technological approach. The average crystallite size of the Cr3C2-25(Ni20Cr) powder decreased rapidly from 145 nm to 50 nm in the initial stages of milling and thereafter decreased slowly to a steady state value of around 10 nm with further increase in milling time. This steady state corresponds to the beginning of a dynamic recovery process. The maximum lattice strain (ε = 1,17%) was observed in powders milled for 16 hours, and this powders critical crystallite size was 28 nm. In contrast, the lattice parameter attained a minimum for powders milled for 16 hours. Upon reaching the critical crystallite size, the dislocation density attained a steady state regime and all plastic deformation introduced in the material there after was in the form of events occurring at the grain boundaries, due mainly to grain boundary sliding. The deformation energy stored in the crystal lattice of the Cr3C2-25(Ni20Cr) powders milled for different times was determined from enthalpy variation measurements. These results indicated that the maximum enthalpy variation (δH = 722 mcal) also occurred for powders milled for 16 hours. In a similar manner, the maximum specific heat variation (δCp = 0,278 cal/gK) occurred for powders milled for 16 hours. The following mechanical properties of Cr3C2-25(Ni20Cr) coatings prepared using the HVOF thermal spray process were determined: Vickers micro

  17. Mechanism-based inhibition of a mutant Escherichia coli ribonucleotide reductase (cysteine-225----serine) by its substrate CDP.

    Mao, S. S.; Johnston, M I; Bollinger, J M; Stubbe, J.

    1989-01-01

    The B1 subunit of Escherichia coli ribonucleotide reductase (EC 1.17.4.1) has been overexpressed using the pT7-5/pGP1-2 system developed by Tabor and Richardson [Tabor, S. & Richardson, C. (1985) Proc. Natl. Acad. Sci. USA 82, 1074-1078]. This method has allowed the preparation of two mutant B1 subunits in which two of the four thiols postulated to be within the active site of the enzyme, Cys-225 and Cys-759, have been changed to serines. Incubation of the [Ser225]B1 mutant with the B2 subuni...

  18. Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for 223Ra and 225Ra for targeted alpha therapy

    Introduction: Targeted alpha therapy (TAT) has the potential for killing micro-metastases with minimum collateral damage to surrounding healthy tissue. In-vivo generator radionuclides, such as223Ra, 225Ra, and 225Ac, are of special interest for radiotherapeutic applications as they emit multiple α-particles during their decay. Utilizing appropriate carriers capable of retaining both the parent radioisotope as well as daughter products is important for the effective delivery of the radioisotope to the tumor site while mitigating global in vivo radiotoxicity. In this work, LaPO4 core and core + 2 shells nanoparticles (NPs) (NPs with 2 layers of cold LaPO4 deposited on the core surfaces) were synthesized containing either 223Ra or225Ra/225Ac, and the retention of the parents and daughters within the NPs in vitro was investigated. Methods: Core LaPO4 NPs were synthesized in aqueous solution by reacting 1 equivalent of La(NO3)3, along with few microcuries of either 223Ra or 225Ra/225Ac, with 1 equivalent of sodium tripolyphosphate (TPP) under moderate heating and purified by membrane dialysis. Core-shell NPs were also synthesized with one (core + 1 shell) and two (core + 2 shells) cold LaPO4 layers deposited onto the radioactive cores. The NPs were then characterized by transmission electron microscopy (TEM) and powder x-ray diffraction (XRD). Identification and quantification of radioactive parents and daughters released from the NPs in vitro were investigated using gamma-ray spectroscopy. Results: XRD and TEM analysis revealed that the NPs crystallized in the rhabdophane phase with mean diameters of 3.4 and 6.3 nm for core and core + 2 shells, respectively. The core LaPO4 NPs retained up to 88% of 223Ra over 35 days. However, in the core + 2 shells NPs, the retention of 223Ra and its daughter, 211Pb, was improved to > 99.9% over 27 days. Additionally, the retention of 225Ra/225Ac parents was > 99.98% and ~ 80% for the 221Fr and 213Bi daughters over 35 days for the

  19. 12 CFR 225.88 - How to request the Board to determine that an activity is financial in nature or incidental to a...

    2010-01-01

    ... activity is financial in nature or incidental to a financial activity? 225.88 Section 225.88 Banks and... request the Board to determine that an activity is financial in nature or incidental to a financial activity? (a) Requests regarding activities that may be financial in nature or incidental to a...

  20. 12 CFR 225.176 - How do the statutory cross marketing and sections 23A and B limitations apply to merchant banking...

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false How do the statutory cross marketing and sections 23A and B limitations apply to merchant banking investments? 225.176 Section 225.176 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK...

  1. 20 CFR 30.225 - What are the criteria for eligibility for benefits under Part B of EEOICPA for certain uranium...

    2010-04-01

    ... benefits under Part B of EEOICPA for certain uranium employees? 30.225 Section 30.225 Employees' Benefits... COMPENSATION PROGRAM ACT OF 2000, AS AMENDED Eligibility Criteria Eligibility Criteria for Certain Uranium... of EEOICPA for certain uranium employees? In order to be eligible for benefits under this...

  2. 45 CFR 1173.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-10-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 45 Public Welfare 3 2010-10-01 2010-10-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 1173.225 Section 1173.225 Public...

  3. 28 CFR 83.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-07-01

    ... employees who are convicted of drug violations in the workplace? 83.225 Section 83.225 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) GOVERNMENT-WIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS... are convicted of drug violations in the workplace? There are two actions you must take if an...

  4. 13 CFR 147.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-01-01

    ... concerning employees who are convicted of drug violations in the workplace? 147.225 Section 147.225 Business... employees who are convicted of drug violations in the workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a) First, you must notify Federal agencies...

  5. 22 CFR 1008.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-04-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 22 Foreign Relations 2 2010-04-01 2010-04-01 true What actions must I take concerning employees who are convicted of drug violations in the workplace? 1008.225 Section 1008.225 Foreign...

  6. 45 CFR 1155.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-10-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 45 Public Welfare 3 2010-10-01 2010-10-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 1155.225 Section 1155.225 Public...

  7. 15 CFR 29.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-01-01

    ... employees who are convicted of drug violations in the workplace? 29.225 Section 29.225 Commerce and Foreign... employees who are convicted of drug violations in the workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a) First, you must notify Federal agencies...

  8. 24 CFR 21.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-04-01

    ... employees who are convicted of drug violations in the workplace? 21.225 Section 21.225 Housing and Urban... actions must I take concerning employees who are convicted of drug violations in the workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a)...

  9. 41 CFR 105-74.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-07-01

    ... concerning employees who are convicted of drug violations in the workplace? 105-74.225 Section 105-74.225... workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a) First, you must notify Federal agencies if an employee who is engaged in the performance...

  10. 38 CFR 48.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-07-01

    ... concerning employees who are convicted of drug violations in the workplace? 48.225 Section 48.225 Pensions... What actions must I take concerning employees who are convicted of drug violations in the workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace:...

  11. 21 CFR 1405.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-04-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 21 Food and Drugs 9 2010-04-01 2010-04-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 1405.225 Section 1405.225 Food and Drugs OFFICE...

  12. 10 CFR 607.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-01-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 10 Energy 4 2010-01-01 2010-01-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 607.225 Section 607.225 Energy DEPARTMENT OF...

  13. 34 CFR 84.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-07-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 34 Education 1 2010-07-01 2010-07-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 84.225 Section 84.225 Education Office of the...

  14. 20 CFR 439.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 439.225 Section 439.225 Employees' Benefits... are convicted of drug violations in the workplace? There are two actions you must take if an...

  15. 2 CFR 182.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-01-01

    ... employees who are convicted of drug violations in the workplace? 182.225 Section 182.225 Grants and... the workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a) First, you must notify Federal agencies if an employee who is engaged in...

  16. 40 CFR 36.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-07-01

    ... employees who are convicted of drug violations in the workplace? 36.225 Section 36.225 Protection of... workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a) First, you must notify Federal agencies if an employee who is engaged in the performance...

  17. 36 CFR 1212.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-07-01

    ... concerning employees who are convicted of drug violations in the workplace? 1212.225 Section 1212.225 Parks... workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a) First, you must notify Federal agencies if an employee who is engaged in the performance...

  18. 14 CFR 1267.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-01-01

    ... employees who are convicted of drug violations in the workplace? 1267.225 Section 1267.225 Aeronautics and... concerning employees who are convicted of drug violations in the workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a) First, you must...

  19. 49 CFR 32.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-10-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 49 Transportation 1 2010-10-01 2010-10-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 32.225 Section 32.225 Transportation Office of...

  20. 22 CFR 133.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-04-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 22 Foreign Relations 1 2010-04-01 2010-04-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 133.225 Section 133.225 Foreign...

  1. 43 CFR 43.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-10-01

    ... employees who are convicted of drug violations in the workplace? 43.225 Section 43.225 Public Lands... concerning employees who are convicted of drug violations in the workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a) First, you must...

  2. 22 CFR 1509.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-04-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 22 Foreign Relations 2 2010-04-01 2010-04-01 true What actions must I take concerning employees who are convicted of drug violations in the workplace? 1509.225 Section 1509.225 Foreign...

  3. 31 CFR 20.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 20.225 Section 20.225 Money and Finance... abuse assistance or rehabilitation program approved for these purposes by a Federal, State or...

  4. 43 CFR 2.25 - How will a bureau handle a request for Federally-funded research data in the possession of a...

    2010-10-01

    ... Federally-funded research data in the possession of a private entity? 2.25 Section 2.25 Public Lands... findings are used by a bureau in developing an agency action, e.g., a policy or regulation, research data... for such research data, the bureau will require the recipient to provide the information to it...

  5. Microstructural evaluation and non-destructive examination of 2.25 Cr--1 Mo steel

    Specimens of 2.25 Cr-1 Mo steel were damaged to various levels by creep and combined creep-fatigue cycling at 8860K (11000F) with hold periods. Ultrasonic shear wave velocity measurements were performed and showed small changes with large amounts of creep or fatigue damage; these changes were deemed too small for practical application. Measurements of magnetic properties were unsuccessful in following damage. Optical and transmission electron microscopy (TEM) were performed on the samples. TEM observations showed that microstructural changes which occurred at 8860K (11000F) did not occur homogeneously throughout the matrix; during creep, carbide spheroidization and coarsening began in widely separated regions, with an increasing fraction of the material undergoing the process with time. A precipitate was observed to form during fatigue which did not occur during simple aging or creep

  6. CT of the liver and spleen with EOE-13: review of 225 examinations

    Miller, D.L.; Vermess, M.; Doppman, J.L.; Simon, R.M.; Sugarbaker, P.H.; O' Leary, T.J.; Grimes, G.; Chatterji, D.G.; Willis, M.

    1984-08-01

    EOE-13 is an experimental liver-spleen-specific computed tomographic (CT) contrast agent developed at the National Institutes of Health. Experience with this agent in 225 clinical examinations is described. On average, use of EOE-13 increases the attenuation of normal liver by 32.5 H and that of normal spleen by 52.3 H. Tumors in these organs increase only 2.6 H, making them more easily detectable. Most of the iodine in EOE-13 appears to clear from the liver and spleen by 24 hr after injection. No deaths or permanent morbidity have been observed. The complication rate is 3.6%. EOE-13 is valuable for the detection of hepatic and splenic tumors.

  7. NASA Rocket Propulsion Test Replacement Effort for Oxygen System Cleaner - Hydrochlorofluorocarbon (HCFC) 225

    DeWitt Burns, H.; Mitchell, Mark A.; Lowrey, Nikki M.; Farner, Bruce R.; Ross, H. Richard

    2014-01-01

    Gaseous and liquid oxygen are extremely reactive materials used in bipropellant propulsion systems. Both flight and ground oxygen systems require a high level of cleanliness to support engine performance, testing, and prevent mishaps. Solvents used to clean and verify the cleanliness of oxygen systems and supporting test hardware must be compatible with the system's materials of construction and effective at removing or reducing expected contaminants to an acceptable level. This paper will define the philosophy and test approach used for evaluating replacement solvents for the current Marshall Space Flight Center/Stennis Space Center baseline HCFC-225 material that will no longer be available for purchase after 2014. MSFC/SSC applications in cleaning / sampling oxygen propulsion components, support equipment, and test system were reviewed then candidate replacement cleaners and test methods selected. All of these factors as well as testing results will be discussed.

  8. Observation of the 22.5-keV Resonance in S

    We have observed coherent nuclear resonant scattering of synchrotron radiation at the 22.5-keV resonance of 149Sm . High-speed rotational sample motion led to an angular deflection of the resonantly scattered radiation off the nonresonant primary beam. This allowed us to determine the resonance energy of the first excited nuclear level of 149Sm to be 22496(4) eV. Because of the angular deflection of the resonant photons, time spectra of coherent nuclear resonant scattering can be recorded as a function of a spatial coordinate. Time resolutions of a few 10ps can be expected, which are beyond the limits of existing x-ray detection schemes

  9. Stress corrosion cracking behavior of quenched and tempered 2.25Cr 1Mo steel

    For stress corrosion cracking (SCC) study of 2.25Cr-1Mo steel, speciemens were initially austenitized at 925 degree C for 2 hours and quenched in ice brine solution. With this process of heat treatment martensite was formed and banded morphology in the microstructure developed during previous processing was also removed. Tempering at 575 Degree C for 1h was employed to introduce ductility in the quenched martensite of the specimens. The effects of temperature variations on SCC behavior showed a successive decrease in strength and ductility of the steel. These variations in tensile properties were correlated with scanning electron microscopic (SEM) examinations. The SEM results clearly revealed that mostly transgranular cracks initiated at the edges of the tensile specimens grown perpendicular to loading axes, and their intensity is increased with the testing temperatures. (author)

  10. Welded joint properties of 08Cr2.25Mo1NiNb type steel

    The results are given of a study into the effect of the chemical composition on the mechanical and structural properties of welded joint of steel 08Cr2.25Mo1NiNb. The welded joints were obtained by manual arc welding using coated electrodes. For assessing short-term strength and plastic properties, tensile tests at normal temperature, notch toughness tests, hardness measurements and bending tests were conducted. The welded joint microstructure was also analysed. The minimal values of the yield point can be obtained in welded joints of melts with the Nb content at a level of the stabilization ratio. The highest hardness values were obtained in the welding metal ranges, which, however, does not negatively affect the plastic properties of the joint. Lower values of notch toughness were found for welding metals with higher carbon content. (M.S.)

  11. Laser-trapping of Ra-225 and Ra-226 with repumping by room temperature blackbody radiation

    Guest, J R; Bailey, K; Greene, J P; Holt, R J; Lu, Z T; O'Connor, T P; Potterveld, D H; Scielzo, N D

    2007-01-01

    We have demonstrated Zeeman slowing and capture of neutral Ra-225 and Ra-226 atoms in a magneto-optical trap (MOT). The intercombination transition 1S0-3P1 is the only quasi-cycling transition in radium and was used for laser-cooling and trapping. Repumping along the 3D1-1P1 transition extended the lifetime of the trap from milliseconds to seconds. Room-temperature blackbody radiation was demonstrated to provide repumping from the metastable 3P0 level. We measured the isotope shift and hyperfine splittings on the 3D1-1P1 transition with the laser-cooled atoms, and set a limit on the lifetime of the 3D1 level based on the measured blackbody repumping rate. Laser-cooled and trapped radium is an attractive system for studying fundamental symmetries.

  12. Laser trapping of 225Ra and 226Ra with repumping by room-temperature blackbody radiation.

    Guest, J R; Scielzo, N D; Ahmad, I; Bailey, K; Greene, J P; Holt, R J; Lu, Z-T; O'Connor, T P; Potterveld, D H

    2007-03-01

    We have demonstrated Zeeman slowing and capture of neutral 225Ra and 226Ra atoms in a magneto-optical trap. The intercombination transition 1S0-->3P1 is the only quasicycling transition in radium and was used for laser-cooling and trapping. Repumping along the 3D1-->1P1 transition extended the lifetime of the trap from milliseconds to seconds. Room-temperature blackbody radiation was demonstrated to provide repumping from the metastable 3P0 level. We measured the isotope shift and hyperfine splittings on the 3D1-->1P1 transition with the laser-cooled atoms, and set a limit on the lifetime of the 3D1 level based on the measured blackbody repumping rate. Laser-cooled and trapped radium is an attractive system for studying fundamental symmetries. PMID:17359153

  13. Cyclic and isothermal oxidation behavior of 2.25Cr-1Mo steel

    Cyclic and isothermal oxidation of chromium-molybdenum steel 2.25Cr-1Mo were analyzed at 550 degree centigrade and 650 degree centigrade during 360 hours in air atmospheres. The cycles were performed with two stages; one of heating in furnace during 90 minutes and then the sample were cooled to 50 degree centigrade by air flow. Thermogravimetric analyses were performed to obtain high temperature corrosion kinetics. Several characterization techniques have been used to identify the corrosion mechanism, as X-Ray Diffraction (XRD), Optical Microscopy (OM) and Scanning Electron Microscopy (SEM). Thermal cycling tests can changes the corrosion mechanism, due cracks propagation in oxide scale, that witch can favors the access of oxidant agent to the substrate. (Author)

  14. Preliminary Therapy Evaluation of 225Ac-DOTA-c(RGDyK) Demonstrates that Cerenkov Radiation Derived from 225Ac Daughter Decay Can Be Detected by Optical Imaging for In Vivo Tumor Visualization

    Pandya, Darpan N.; Hantgan, Roy; Budzevich, Mikalai M.; Kock, Nancy D.; Morse, David L.; Batista, Izadora; Mintz, Akiva; Li, King C.; Wadas, Thaddeus J.

    2016-01-01

    The theranostic potential of 225Ac-based radiopharmaceuticals continues to increase as researchers seek innovative ways to harness the nuclear decay of this radioisotope for therapeutic and imaging applications. This communication describes the evaluation of 225Ac-DOTA-c(RGDyK) in both biodistribution and Cerenkov luminescence imaging (CLI) studies. Initially, La-DOTA-c(RGDyK) was prepared as a non-radioactive surrogate to evaluate methodologies that would contribute to an optimized radiochemical synthetic strategy and estimate the radioactive conjugate's affinity for αvβ3, using surface plasmon resonance spectroscopy. Surface plasmon resonance spectroscopy studies revealed the IC50 and Ki of La-DOTA-c(RGDyK) to be 33 ± 13 nM and 26 ± 11 nM, respectively, and suggest that the complexation of the La3+ ion to the conjugate did not significantly alter integrin binding. Furthermore, use of this surrogate allowed optimization of radiochemical synthesis strategies to prepare 225Ac-DOTA-c(RGDyK) with high radiochemical purity and specific activity similar to other 225Ac-based radiopharmaceuticals. This radiopharmaceutical was highly stable in vitro. In vivo biodistribution studies confirmed the radiotracer's ability to target αvβ3 integrin with specificity; specificity was detected in tumor-bearing animals using Cerenkov luminescence imaging. Furthermore, tumor growth control was achieved using non-toxic doses of the radiopharmaceutical in U87mg tumor-bearing nude mice. To our knowledge, this is the first report to describe the CLI of αvβ3+ tumors in live animals using the daughter products derived from 225Ac decay in situ. This concept holds promise to further enhance development of targeted alpha particle therapy. PMID:27022417

  15. 12 CFR Appendix G to Part 225 - Capital Adequacy Guidelines for Bank Holding Companies: Internal-Ratings-Based and Advanced...

    2010-01-01

    ... company that uses 12 CFR part 225, appendix G, to calculate its risk-based capital requirements. (2) Any... (FFIEC) 009 Country Exposure Report); (iii) Is a subsidiary of a depository institution that uses 12 CFR part 3, appendix C, 12 CFR part 208, appendix F, 12 CFR part 325, appendix D, or 12 CFR part...

  16. 25 CFR 225.5 - Authority and responsibility of the Office of Surface Mining Reclamation and Enforcement (OSMRE).

    2010-04-01

    ... relevant regulations for surface mining and reclamation operations are found in 30 CFR part 750 and 25 CFR... § 225.5 Authority and responsibility of the Office of Surface Mining Reclamation and Enforcement (OSMRE). The OSMRE is the regulatory authority for surface coal mining and reclamation operations on...

  17. 20 CFR 225.54 - Recomputation when an employee is eligible for periodic pension payments based on other than...

    2010-04-01

    ... for periodic pension payments based on other than railroad or social security earnings. 225.54 Section... eligible for periodic pension payments based on other than railroad or social security earnings. (a) Description. This recomputation serves as a reduction in the PIA for entitlement to a periodic pension...

  18. 75 FR 79312 - Special Conditions: Eurocopter France (ECF) Model EC225LP Helicopter, Installation of a Search...

    2010-12-20

    .... Special conditions No. 29-022-SC, published in the Federal Register on November 6, 2008 (73 FR 65968... operations conducted over water in offshore areas clear of obstructions. The SAR modes enable the helicopter... model EC225LP helicopters was published in the Federal Register on November 6, 2008 (73 FR 65968),...

  19. 76 FR 70531 - Fifth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems-Small...

    2011-11-14

    ... Federal Aviation Administration Fifth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is issuing this notice to advise...

  20. 77 FR 66084 - Tenth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems-Small...

    2012-11-01

    ... Federal Aviation Administration Tenth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is issuing this notice...

  1. 77 FR 56253 - Ninth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems-Small...

    2012-09-12

    ... Federal Aviation Administration Ninth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is issuing this notice...

  2. 12 CFR 225.14 - Expedited action for certain bank acquisitions by well-run bank holding companies.

    2010-01-01

    ...-capitalized organization—(i) Bank holding company. Both at the time of and immediately after the proposed... acquiring bank holding company is undercapitalized; (2) Well managed organization—(i) Satisfactory... required and public notice. As an alternative to the procedure provided in § 225.15, a bank holding...

  3. 48 CFR 52.225-4 - Buy American Act-Free Trade Agreement-Israeli Trade Act Certificate.

    2010-10-01

    ... CLAUSES Text of Provisions and Clauses 52.225-4 Buy American Act—Free Trade Agreement—Israeli Trade Act... product,” “foreign end product,” “Free Trade Agreement country,” “Free Trade Agreement country end product... American Act—Free Trade Agreements—Israeli Trade Act.” (b) The offeror certifies......

  4. Neutron capture therapy of epidermal growth factor (+) gliomas using boronated cetuximab (IMC-C225) as a delivery agent

    Cetuximab (IMC-C225) is a monoclonal antibody directed against both the wild-type and mutant vIII isoform of the epidermal growth factor receptor (EGFR). The purpose of the present study was to evaluate the monoclonal antibody (MoAb), cetuximab, as a boron delivery agent for neutron capture therapy (NCT) of brain tumors. Twenty-four hours following intratumoral (i.t.) administration of boronated cetuximab (C225-G5-B1100), the mean boron concentration in rats bearing either F98EGFR or F98WT gliomas were 92.3±23.3 μg/g and 36.5±18.8 μg/g, respectively. In contrast, the uptake of boronated dendrimer (G5-B1000) was 6.7±3.6 μg/g. Based on its favorable in vivo uptake, C225-G5-B1100 was evaluated as a delivery agent for BNCT in F98EGFR glioma bearing rats. The mean survival time (MST) of rats that received C225-G5-B1100, administered by convection enhanced delivery (CED), was 45±3 d compared to 25±3 d for untreated control animals. A further enhancement in MST to >59 d was obtained by administering C225-G5-B1100 in combination with i.v. boronophenylalanine (BPA). These data are the first to demonstrate the efficacy of a boronated MoAb for BNCT of an intracerebral (i.c.) glioma and are paradigmatic for future studies using a combination of boronated MoAbs and low molecular weight delivery agents

  5. Neutron capture therapy of epidermal growth factor (+) gliomas using boronated cetuximab (IMC-C225) as a delivery agent

    Barth, Rolf F. E-mail: barth.1@osu.edu; Wu Gong; Yang Weilian; Binns, Peter J.; Riley, Kent J.; Patel, Hemant; Coderre, Jeffrey A.; Tjarks, Werner; Bandyopadhyaya, A.K.; Thirumamagal, B.T.S.; Ciesielski, Michael J.; Fenstermaker, Robert A

    2004-11-01

    Cetuximab (IMC-C225) is a monoclonal antibody directed against both the wild-type and mutant vIII isoform of the epidermal growth factor receptor (EGFR). The purpose of the present study was to evaluate the monoclonal antibody (MoAb), cetuximab, as a boron delivery agent for neutron capture therapy (NCT) of brain tumors. Twenty-four hours following intratumoral (i.t.) administration of boronated cetuximab (C225-G5-B{sub 1100}), the mean boron concentration in rats bearing either F98{sub EGFR} or F98{sub WT} gliomas were 92.3{+-}23.3 {mu}g/g and 36.5{+-}18.8 {mu}g/g, respectively. In contrast, the uptake of boronated dendrimer (G5-B{sub 1000}) was 6.7{+-}3.6 {mu}g/g. Based on its favorable in vivo uptake, C225-G5-B{sub 1100} was evaluated as a delivery agent for BNCT in F98{sub EGFR} glioma bearing rats. The mean survival time (MST) of rats that received C225-G5-B{sub 1100}, administered by convection enhanced delivery (CED), was 45{+-}3 d compared to 25{+-}3 d for untreated control animals. A further enhancement in MST to >59 d was obtained by administering C225-G5-B{sub 1100} in combination with i.v. boronophenylalanine (BPA). These data are the first to demonstrate the efficacy of a boronated MoAb for BNCT of an intracerebral (i.c.) glioma and are paradigmatic for future studies using a combination of boronated MoAbs and low molecular weight delivery agents.

  6. Failure Analysis of Resonance Induced by Von Karman Vortex Shedding from Runner Blades for Dachaoshan 225MW Hydro Unit%大朝山电站225MW水轮机转轮卡门涡共振分析

    石清华; 尹国军

    2005-01-01

    分析了云南大朝山电站225MW水轮发电机组运行时发生卡门涡共振,产生金属蜂鸣声及叶片裂纹的原因,经分析处理并取得成功,为大型水轮机的安全运行提供了经验.图4表2

  7. Production of charmonium states in 225 GeV/c pi-minus beryllium interactions

    This thesis reports on the analysis of data obtained during the FNAL experiment E610. The Chicago Cyclotron Magnet Spectrometer was used to perform a study of the hadronic production of charmonium. A 225 GeV/c negative pion beam was incident on a beryllium target. The trigger required a dimuon signature which favored opposite sign muon pairs with a large combined p/sub tau/. A search was then made for chi mesons of the charmonium spectrum by combining J/psi mesons found in the dimuon spectrum with photons detected in a large lead glass shower detector. These events were used to determine the fraction of J/psis produced from chis. A psi(3685) signal seen in the dimuon spectrum was used to determine the fraction of J/psis resulting from psi(3685). Assuming that these are the only particles decaying to J/psi, we obtain the fraction of J/psis produced directly in hadronic collisions - 0.58 +- 0.09 - which is relevant to the production mechanism for charmonium in strong interactions

  8. Magnetic-Field-Assisted Terahertz Quantum Cascade Laser Operating up to 225 K

    Wade, A.; Fedorov, G.; Smirnov, D.; Kumar, S.; Williams, B. S.; Hu, Q.; Reno, J. L.

    2008-01-01

    Advances in semiconductor bandgap engineering have resulted in the recent development of the terahertz quantum cascade laser1. These compact optoelectronic devices now operate in the frequency range 1.2-5 THz, although cryogenic cooling is still required2.3. Further progress towards the realization of devices operating at higher temperatures and emitting at longer wavelengths (sub-terahertz quantum cascade lasers) is difficult because it requires maintaining a population inversion between closely spaced electronic sub-bands (1 THz approx. equals 4 meV). Here, we demonstrate a magnetic-field-assisted quantum cascade laser based on the resonant-phonon design. By applying appropriate electrical bias and strong magnetic fields above 16 T, it is possible to achieve laser emission from a single device over a wide range of frequencies (0.68-3.33 THz). Owing to the suppression of inter-landau-level non-radiative scattering, the device shows magnetic field assisted laser action at 1 THz at temperatures up to 215 K, and 3 THz lasing up to 225 K.

  9. Simulated weld HAZ of vanadium modified 2.25 Cr-1Mo steel

    The effect of the weld heat affected zone (HAZ) on microstructure, mechanical properties and hydrogen embrittlement susceptibility of vanadium modified 2.25Cr-1Mo steel (V-Mod Steel) has been studied to examine the viability of using V-Mod steel for reactor applications. The weld HAZ was simulated on the assumption that the submerged arc welding was made for the V-Mod steel with input heat of about 40 kJ/cm. When the weld HAZ was heated to 1123 K, the strength was somewhat decreased, while the 0.2% proof strength exceeded considerably the critical value (415 MPa) established for reactors. Heating the weld HAZ in the region of 1173 to 1473 K had a beneficial effect on the strength and ductile-to-brittle transition temperature. Compared to the base metal, the weld HAZ heated in the region of 1123 to 1673 K exhibited equal or superior hydrogen charged and initial mechanical properties. The results illustrate that the weld HAZ for the V-Mod steel has not only sufficient mechanical properties which could withstand the operation under severely stressed conditions but also beneficial effects on hydrogen embrittlement susceptibility. (orig.)

  10. Production of charmonium states in 225 GeV/c π-minus beryllium interactions

    This thesis reports on the analysis of data obtained during FNAL experiment E610. The Chicago Cyclotron Magnet Spectrometer was used to perform a study of the hadronic production of charmonium. A 225 GeV/c negative pion beam was incident on a beryllium target. The trigger required a dimuon signature which favored opposite sign muon pairs with a large combined p/sub tau/. A search was then made for chi mesons of the charmonium spectrum by combining J/psi mesons found in the dimuon spectrum with photons detected in a large lead glass shower detector. These events were used to determine the fraction of J/psi s produced from chi s. A psi(3685) signal seen in the dimuon spectrum was used to determine the fraction of J/psi s resulting from psi(3685). Assuming that these are the only particles decaying to J/psi, we obtain the fraction of J/psi s produced directly in hadronic collisions - 0.58 +- 0.09 - which is relevant to the production mechanism for charmonium in strong interactions

  11. Study of 225 deg C thermoluminescent of quartz inclusions extracted from cementitious building materials

    Incidents of excessive exposure of the population to ionizing radiation could result from a nuclear explosion, the direct exposure to a source theft or loss or an accidental exposure to a source without shielding, for example. During these incidents the victims seldom are using individual protection equipment used in the measurement and control of the doses that were exposed. One of the ways found to the doses assessment due to exposure to this type of accident is the retrospective dosimetry, which determines the excessive doses of radiation exposure, whether chronological or acute, using common materials available in the public domain. The methodology for the application of retrospective dosimetry for thermoluminescence in buildings previously burned, as bricks, it is already well established. Interest is now turning to the use of cementitious building materials such as mortar and concrete to enlarge the scope of application. This study aimed to examine some of these materials and techniques for their possible application in the doses assessment from an accidental irradiation by thermoluminescence. For this the peak about 225 deg C of natural quartz and it extracted of mortar and concrete was certain your stability for the plateau and storage tests, and also the dependence of your luminescent intensity with radiation dose. Presenting a life relatively tans compared enough to that of the accumulation of natural and long radiation sign for dosimetric applications, besides other favorable characteristics, the mortar presented evidence that is possible for retrospective dosimetry through thermoluminescence. (author)

  12. Electric dipole moment of $^{225}$Ra due to P- and T-violating weak interactions

    Singh, Yashpal

    2015-01-01

    We report rigorous calculations of electric dipole moment (EDM) in $^{225}$Ra due to parity and time-reversal violating tensor-pseudotensor (T-PT) and nuclear Schiff moment (NSM) interactions between the electrons and nucleus by employing the relativistic all order coupled-cluster (RCC) methods at various levels of approximation. The most accurate EDM ($d_A$) results are obtained as $d_A=-10.04\\times 10^{-20} C_T |e|cm$ and $d_A^{NSM}=-6.79 \\times 10^{-17} S (|e|fm^3)^{-1} |e|cm$ with $C_T$ and $S$ are the T-PT coupling constant and NSM respectively. Due to exhaustive treatment of the electron correlation effects in these calculations, the EDM results for the corresponding T-PT and NSM interactions reduce by about 45\\% and 23\\%, respectively, from the previously known values. Nonetheless they are still found to be 2-3 times larger than the $^{199}$Hg results. Validity of the RCC results are countenanced by comparing our calculations at the zeroth order Dirac-Fock method and all order random-phase approximatio...

  13. Underwater Laser-illuminated Range-gated Imaging Scaled by 22.5 cm ns-1 with Serial Targets

    HE Duo-Min

    2004-01-01

    We have developed a novel target set to scale our Underwater Laser-illuminated Range-gated Imaging(ULRI)video system in a 3 m-tank with turbid water(attenuation coefficient 1.0 m-1). As light speed in water is 22.5 cm ns-1, the target set consists of a series of 3-bar targets at 22.5 cm intervals along the laser illumination direction, with the targets separated vertically. As a result, a sequence of good gated images, in steps of 1 ns delay, is presented, which is a revelation of the' sliced-view' phenomenon for ns-level range-gating in such a limited water body. The Depth of Gating(DOG)and DOG-profile of the URLI system are measured for the first time, which can be used for evaluating gating-performance efficiently.

  14. Extending the emission wavelength of Ge nanopillars to 2.25 μm using silicon nitride stressors

    Millar, R.W.; Gallacher, K.; Samarelli, A.; Frigerio, J.; Chrastina, D.; Isella, G.; Dieing, T.; Paul, D. J.

    2015-01-01

    The room temperature photoluminescence from Ge nanopillars has been extended from 1.6 μm to above 2.25 μm wavelength through the application of tensile stress from silicon nitride stressors deposited by inductively-coupled-plasma plasma-enhanced chemical-vapour-deposition. Photoluminescence measurements demonstrate biaxial equivalent tensile strains of up to ~ 1.35% in square topped nanopillars with side lengths of 200 nm. Biaxial equivalent strains of 0.9% are observed in 3...

  15. IE Information No. 87-12: Potential problems with metal clad circuit breakers, General Electric type AKF-2-25

    This notice is to alert recipients of potential problems with the General Electric Company (GE) AKF-2-25 type circuit breakers failing to fully open on demand. The GE AKF type circuit breakers have been shown to be susceptible to failure as a result of binding within the breaker cam mechanism, unless proper maintenance procedures are developed and followed by individuals trained specifically to service the AKF breaker. Maintenance information is given that should be incorporated into programs for these circuit breakers

  16. An analysis of international situation concerning nuclear security. Focused on the revision to INFCIRC/225/Rev.5

    Since the September 11 attacks in 2001, counterterrorism measures have become not just domestic issues but critical issues that need international cooperation. Various nuclear security measures are in place as part of international counterterrorism measures. This report looks at the trend of international nuclear security measures to get implications for Japan, focusing on INFCIRC/225/Rev.5, an international guideline for physical protection of nuclear materials and nuclear facilities drawn up by IAEA. The observations of this report are as follows: 1) While legally binding nuclear security measures such as multilateral treaties and United Nations Security Council Resolutions impose minimum requirements on individual countries, the approaches led by IAEA or individual countries or private associations aim at more detailed consideration or information sharing to further improve nuclear security. 2) INFCIRC/225/Rev.5 comprises new concepts such as risk-based physical protection and nuclear security culture, as well as extended range of threats such as insiders or stand-off attacks and broader scope of measures to response. Japan should consider incorporation of INFCIRC/225/Rev.5 to its national laws and regulations putting in mind that it may have heavy influence and that Japan pledged to role leadership about nuclear security to international society. (author)

  17. BWR shutdown and startup chemistry experience and application Sourcebook. BWRVIP-225, Rev. 1

    BWR water chemistry has changed significantly over the years with the adoption of hydrogen water chemistry (HWC), noble metal chemical application (NMCA), and most recently, Online NobleChem™ (OLNC). Some plants have experienced large increases in activated corrosion products during shutdown evolutions, when the chemistry environment at primary system surfaces transitions from reducing to oxidizing conditions. Higher activity releases may be in part related to the more reducing conditions brought about by the above mentioned processes during the operating cycle. With shorter outages decreasing the available cleanup time, some plants are experiencing increased outage radiation exposure. A significant portion of fuel cycle intergranular stress corrosion cracking (IGSCC) propagation of reactor internals and primary system piping is indicated to occur during startup and early power ascension, when dissolved oxygen and hydrogen peroxide concentrations in the reactor coolant are high and hydrogen injection is unavailable. The majority of lost hydrogen availability hours typically occurs during early startup. Startup periods following refueling outages are also when reactor coolant chemistry transients may occur due to system flow changes and residual chemical impurities from outage related work activities. Test results show that IGSCC is accelerated particularly during early startup periods of elevated reactor coolant oxidant concentrations (dissolved oxygen and hydrogen peroxide), particularly when operating at an intermediate temperature range (300 – 400°F, 148-204°C). Based on extensive data collection and evaluation, BWRVIP-225 Revision 1 provides good practices and conditions to avoid during plant refueling outages, including recommendations to minimize activity transport during shutdown conditions to reduce radiation exposure. In addition, good practices and conditions to avoid are provided for startup and power ascension to minimize IGSCC. This paper

  18. Water availability and vulnerability of 225 large cities in the United States

    Padowski, Julie C.; Jawitz, James W.

    2012-12-01

    This study presents a quantitative national assessment of urban water availability and vulnerability for 225 U.S. cities with population greater than 100,000. Here, the urban assessments account for not only renewable water flows, but also the extracted, imported, and stored water that urban systems access through constructed infrastructure. These sources represent important hydraulic components of the urban water supply, yet are typically excluded from water scarcity assessments. Results from this hydraulic-based assessment were compared to those obtained using a more conventional method that estimates scarcity solely based on local renewable flows. The inclusion of hydraulic components increased the mean availability to cities, leading to a significantly lower portion of the total U.S. population considered "at risk" for water scarcity (17%) than that obtained from the runoff method (47%). Water vulnerability was determined based on low-flow conditions, and smaller differences were found for this metric between at-risk populations using the runoff (66%) and hydraulic-based (54%) methods. The large increase in the susceptible population between the scarcity measures evaluated using the hydraulic method may better reconcile the seeming contradiction in the United States between perceptions of natural water abundance and widespread water scarcity. Additionally, urban vulnerability measures developed here were validated using a media text analysis. Vulnerability assessments that included hydraulic components were found to correlate with the frequency of urban water scarcity reports in the popular press while runoff-based measures showed no significant correlation, suggesting that hydraulic-based assessments provide better context for understanding the nature and severity of urban water scarcity issues.

  19. Structure of ω-Ti3Al2.25Nb0.75

    ω phases form by cooling from high-temperature A2 or B2 phases as a result of displacement of some of the atoms in the direction of a body diagonal of the parent phase, accompanied by ordering. The apparent cubic symmetry is caused by quadruple twinning of trigonal cells with their c axes in the directions of the body diagonals of the parent phase. The structure of one of the twin variants of an ω phase in the Ti-Al-Nb system was determined from intensity data collected by X-ray diffractometer with Mo Kα radiation (λ = 0.71069 A). Ti3Al2.25Nb0.75, Mr = 274.1, trigonal, Panti 3m1, a = 4.5554(10), c = 5.5415(14) A, V = 99.59(7) A3, atoms/cell = 6, Dx = 4.57 g cm-3, μ = 83.2 cm-1, F(000) = 126, T = 296 K, final R = 0.032 for 251 (single) reflections with I > 3σ. Ten parameters were refined: two z parameters, four occupancies, and four isotropic temperature factors. The atoms are partially ordered: the Ti atoms on 1(a) (with some Nb mixed in) and 2(d) together occupy the A positions of the B2 substructure; the Nb atoms on 1(b) (with some Al mixed in) together with the Al atoms on 2(d) occupy the B positions. The atom displacements result in some short Al-Ti distances of 2.650(1) A, and long Al-Al and Ti-Ti nearneighbor distances of 3.620(3) and 3.567(2) A respectively. Analysis of the twin reflections indicates that some untransformed cubic material is present. (orig.)

  20. Role of EGFR inhibitor C225 in cerebral inflammation of fetal rats of intrauterine infection%EGFR抑制剂C225在宫内感染仔鼠脑组织炎症中的实验研究

    桑鑫泉; 程远; 李多多; 柳晓燕; 朱凤莲

    2015-01-01

    目的 研究表皮生长因子受体(EGFR)抑制剂C225对宫内感染仔鼠脑组织炎症的影响.方法 应用脂多糖(LPS)感染孕鼠建立宫内感染孕鼠模型,给予EGFR抑制剂C225干预,应用免疫组织化学法检测仔鼠脑组织OX42及磷酸化EGFR表达水平的变化,应用酶联免疫吸附测定法(ELISA)检测小胶质细胞活化产物肿瘤坏死因子-α(TNF-α)及白细胞介素-1β (IL-1β)的表达水平.结果 与对照组相比,模型组孕鼠所产仔鼠脑组织OX42及磷酸化EGFR的表达明显增强(P<0.01),且TNF-α及IL-1β含量明显增高(P<0.01);与模型组相比,经C225干预后,LPS诱导小胶质细胞活化不明显,OX42及磷酸化EGFR表达明显低于模型组(P<0.01),TNF-α及IL-1β含量也低于模型组(P<0.01).结论 抑制EGFR通路可明显限制LPS诱导的小胶质细胞的激活,EGFR通路可能在外源性感染引起的小胶质细胞活化过程中起桥梁作用,C225可能在神经损伤修复过程中通过调节小胶质细胞起到重要作用.

  1. Microstructural stability of a nickel-based alloy overlay on a 2.25Cr1Mo steel substrate

    Saghafifar, Hassan

    2011-01-01

    Ni-based superalloy weld overlays are widely used in electricity generating plants to significantly reduce high temperature corrosion problems of ferritic steel components under service conditions. Welding a nickel alloy similar to IN625 onto the outer bore of a 2.25Cr1Mo steel tube enhances its service life as a superheater tube in the highly corrosive environment of a Waste-to-Energy boiler. For the purposes of studying the effects of high temperature service on the microstructure of this l...

  2. Guidance and considerations for the implementation of INFCIRC/225/Rev.4, the physical protection of nuclear material and nuclear facilities

    This publication is intended to provide guidance and considerations for a State's competent authority to better understand and prescribe appropriate requirements, consistent with INFCIRC/225/Rev.4 for the protection of nuclear material and nuclear facilities which are compatible with accepted international practice. This report, together with a more detailed report, Handbook on the Physical Protection of Nuclear Material and Facilities, which addresses to the licencee or designer of physical protection systems who has specific implementation and compliance responsibilities, should be used in conjunction to each other to provide better and comprehensive guidance on physical protection

  3. Guidance and considerations for the implementation of INFCIRC/225/Rev.4, the physical protection of nuclear material and nuclear facilities

    This publication is intended to provide guidance and considerations for a State's competent authority to better understand and prescribe appropriate requirements, consistent with INFCIRC/225/Rev.4 for the protection of nuclear material and nuclear facilities which are compatible with accepted international practice. This report, together with a more detailed report, Handbook on the Physical Protection of Nuclear Material and Facilities, which addresses to the licensee or designer of physical protection systems who has specific implementation and compliance responsibilities, should be used in conjunction to each other to provide better and comprehensive guidance on physical protection

  4. Nuclear Security Recommendations on Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225/Revision 5). Recommendations (Spanish Edition)

    This publication, Revision 5 of Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225), is intended to provide guidance to States and their competent authorities on how to develop or enhance, implement and maintain a physical protection regime for nuclear material and nuclear facilities, through the establishment or improvement of their capabilities to implement legislative and regulatory programmes. The recommendations presented in this publication reflect a broad consensus among IAEA Member States on the requirements which should be met for the physical protection of nuclear materials and nuclear facilities.

  5. Nuclear Security Recommendations on Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225/Revision 5): Recommendations

    This publication, Revision 5 of Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225), is intended to provide guidance to States and their competent authorities on how to develop or enhance, implement and maintain a physical protection regime for nuclear material and nuclear facilities, through the establishment or improvement of their capabilities to implement legislative and regulatory programmes. The recommendations presented in this publication reflect a broad consensus among IAEA Member States on the requirements which should be met for the physical protection of nuclear materials and nuclear facilities.

  6. Nuclear Security Recommendations on Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225/Revision 5). Recommendations (Arabic Edition)

    This publication, Revision 5 of Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225), is intended to provide guidance to States and their competent authorities on how to develop or enhance, implement and maintain a physical protection regime for nuclear material and nuclear facilities, through the establishment or improvement of their capabilities to implement legislative and regulatory programmes. The recommendations presented in this publication reflect a broad consensus among IAEA Member States on the requirements which should be met for the physical protection of nuclear materials and nuclear facilities.

  7. Nuclear security recommendations on physical protection of nuclear material and nuclear facilities (INFCIRC/225/Revision 5). Recommendations (Chinese Edition)

    This publication, Revision 5 of Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225), is intended to provide guidance to States and their competent authorities on how to develop or enhance, implement and maintain a physical protection regime for nuclear material and nuclear facilities, through the establishment or improvement of their capabilities to implement legislative and regulatory programmes. The recommendations presented in this publication reflect a broad consensus among IAEA Member States on the requirements which should be met for the physical protection of nuclear materials and nuclear facilities.

  8. Volatility-constrained correlation identifies the directionality of the influence between Japan’s Nikkei 225 and other financial markets

    Ochiai, Tomoshiro; Nacher, Jose C.

    2014-01-01

    Recent financial crises have shown the importance of determining the directionality of the influence between financial assets in order to identify the origin of market instabilities. Here, we analyze the correlation between Japan’s Nikkei stock average index (Nikkei 225) and other financial markets by introducing a volatility-constrained correlation metric. The asymmetric feature of the metric reveals which asset is more influential than the other. As a result, this method allows us to unveil the directionality of the correlation effect, which could not be observed from the standard correlation analysis. Furthermore, we present a theoretical model that reproduces the results observed in empirical analysis.

  9. Therapeutic efficacy and toxicity of {sup 225}Ac-labelled vs. {sup 213}Bi-labelled tumour-homing peptides in a preclinical mouse model of peritoneal carcinomatosis

    Essler, Markus; Gaertner, Florian C.; Blechert, Birgit; Senekowitsch-Schmidtke, Reingard; Seidl, Christof [Technische Universitaet Muenchen, Department of Nuclear Medicine, Munich (Germany); Neff, Frauke [Helmholtz Zentrum Muenchen, Institute of Pathology, Neuherberg (Germany); Bruchertseifer, Frank; Morgenstern, Alfred [Institute for Transuranium Elements, European Commission, Joint Research Centre, Karlsruhe (Germany)

    2012-04-15

    Targeted delivery of alpha-particle-emitting radionuclides is a promising novel option in cancer therapy. We generated stable conjugates of the vascular tumour-homing peptide F3 both with {sup 225}Ac and {sup 213}Bi that specifically bind to nucleolin on the surface of proliferating tumour cells. The aim of our study was to determine the therapeutic efficacy of {sup 225}Ac-DOTA-F3 in comparison with that of {sup 213}Bi-DTPA-F3. ID{sub 50} values of {sup 213}Bi-DTPA-F3 and {sup 225}Ac-DOTA-F3 were determined via clonogenic assays. The therapeutic efficacy of both constructs was assayed by repeated treatment of mice bearing intraperitoneal MDA-MB-435 xenograft tumours. Therapy was monitored by bioluminescence imaging. Nephrotoxic effects were analysed by histology. ID{sub 50} values of {sup 213}Bi-DTPA-F3 and {sup 225}Ac-DOTA-F3 were 53 kBq/ml and 67 Bq/ml, respectively. The median survival of control mice treated with phosphate-buffered saline was 60 days after intraperitoneal inoculation of 1 x 10{sup 7} MDA-MB-435 cells. Therapy with 6 x 1.85 kBq of {sup 225}Ac-DOTA-F3 or 6 x 1.85 MBq of {sup 213}Bi-DTPA-F3 prolonged median survival to 95 days and 97 days, respectively. While F3 labelled with short-lived {sup 213}Bi (t{sub 1/2} 46 min) reduced the tumour mass at early time-points up to 30 days after treatment, the antitumour effect of {sup 225}Ac-DOTA-F3 (t{sub 1/2} 10 days) increased at later time-points. The difference in the fraction of necrotic cells after treatment with {sup 225}Ac-DOTA-F3 (43%) and with {sup 213}Bi-DTPA-F3 (36%) was not significant. Though histological analysis of kidney samples revealed acute tubular necrosis and tubular oedema in 10-30% of animals after treatment with {sup 225}Ac-DOTA-F3 or {sup 213}Bi-DTPA-F3, protein casts were negligible (2%), indicating only minor damage to the kidney. Therapy with both {sup 225}Ac-DOTA-F3 and {sup 213}Bi-DTPA-F3 increased survival of mice with peritoneal carcinomatosis. Mild renal toxicity of both

  10. Development of Cr{sub 3}C{sub 2}-25(Ni20Cr) nanostructured coatings; Desenvolvimento de revestimentos nanostruturados de Cr{sub 3}C{sub 2}-25(Ni20Cr)

    Cunha, Cecilio Alvares da

    2012-07-01

    This study is divided in two parts. The first part is about the preparation of nanostructured Cr{sub 3}C{sub 2}-25(Ni20Cr) powders by high energy milling followed by characterization of the milled and the as received powder. Analyses of some of the data obtained were done using a theoretical approach. The second part of this study is about the preparation and characterization of coatings prepared with the nanostructured as well as the as received Cr{sub 3}C{sub 2}-25(Ni20Cr) powders. The high temperature erosion-oxidation (E-O) behavior of the coatings prepared with the two types of powders has been compared based on a technological approach. The average crystallite size of the Cr{sub 3}C{sub 2}-25(Ni20Cr) powder decreased rapidly from 145 nm to 50 nm in the initial stages of milling and thereafter decreased slowly to a steady state value of around 10 nm with further increase in milling time. This steady state corresponds to the beginning of a dynamic recovery process. The maximum lattice strain ({epsilon} = 1,17%) was observed in powders milled for 16 hours, and this powders critical crystallite size was 28 nm. In contrast, the lattice parameter attained a minimum for powders milled for 16 hours. Upon reaching the critical crystallite size, the dislocation density attained a steady state regime and all plastic deformation introduced in the material there after was in the form of events occurring at the grain boundaries, due mainly to grain boundary sliding. The deformation energy stored in the crystal lattice of the Cr{sub 3}C{sub 2}-25(Ni20Cr) powders milled for different times was determined from enthalpy variation measurements. These results indicated that the maximum enthalpy variation ({delta}H = 722 mcal) also occurred for powders milled for 16 hours. In a similar manner, the maximum specific heat variation ({delta}C{sub p} = 0,278 cal/gK) occurred for powders milled for 16 hours. The following mechanical properties of Cr{sub 3}C{sub 2}-25(Ni20Cr) coatings

  11. Mechanism-based inhibition of a mutant Escherichia coli ribonucleotide reductase (cysteine-225 → serine) by its substrate CDP

    The B1 subunit of Escherichia coli ribonucleotide reductase has been overexpressed using the pT7-5/pGP1-2 system developed by Tabor and Richardson. This method has allowed the preparation of two mutant B1 subunits in which two of the four thiols postulated to be within the active site of the enzyme, Cys-225 and Cys-759, have been changed to serines. Incubation of the [Ser225]B1 mutant with the B2 subunit, [U-14C]CDP, and the allosteric effector ATP results in production of cytosine, destruction of the tyrosyl radical in B2, radiolabeling of the protein, and cleavage of the B1 subunit into two pieces of 26 and 61.5 kDa. This process is independent of the identity of reductant. The [Ser759]B1 mutant reduces CDP in the presence of thioredoxin/thioredoxin reductase at 7.7% the rate of wild-type B1. When dithiothreitol is utilized as reductant, however, the rate of CDP reduction with [Ser759]B1 is identical to that observed with wild type

  12. Lattice rotation and stability of 22.5 deg. ND rotated cube orientation in cold rolled polycrystalline AA 5182 aluminum alloy

    AA 5182 aluminum alloy with a strong cube texture was cold rolled to different reductions at an angle of 22.5 deg. to the prior rolling direction. The texture evolution at this new rolling direction was investigated by X-ray diffraction. The rotation paths and stability of the 22.5 deg. ND rotated cube orientation were determined based on the variation in the three-dimensional orientation distribution function (ODF) with rolling reduction. The results show that most of the grains with the 22.5 deg. ND rotated cube orientation are directly rotated to the β fiber along different rotation paths, but there are a few grains moving through the cube orientation to the β fiber. The {0 0 1} oriented grains possess the lowest stability during rolling, and the stability increases as the initial orientation changes from the {0 0 1} orientation to the {0 0 1} orientation along the φ1 axis

  13. Cyclic and isothermal oxidation behavior of 2.25Cr-1Mo steel; Estudio del comportamiento del acero 2.25Cr-1Mo frente a los fenomenos de oxidacion ciclica e isoterma

    Proy, M.; Utrilla, M. v.; Otero, E.

    2014-04-01

    Cyclic and isothermal oxidation of chromium-molybdenum steel 2.25Cr-1Mo were analyzed at 550 degree centigrade and 650 degree centigrade during 360 hours in air atmospheres. The cycles were performed with two stages; one of heating in furnace during 90 minutes and then the sample were cooled to 50 degree centigrade by air flow. Thermogravimetric analyses were performed to obtain high temperature corrosion kinetics. Several characterization techniques have been used to identify the corrosion mechanism, as X-Ray Diffraction (XRD), Optical Microscopy (OM) and Scanning Electron Microscopy (SEM). Thermal cycling tests can changes the corrosion mechanism, due cracks propagation in oxide scale, that witch can favors the access of oxidant agent to the substrate. (Author)

  14. Fabrication of a Hydroprocessing Reaction Applying 2.25Cr-1Mo-V-Cb-Ca Steel%采用2.25Cr-1Mo-V-Cb-Ca钢的加氢反应器的制造

    张良成; 徐利柏

    2003-01-01

    2.25Cr-1Mo-V-Cb-Ca和3Cr-1Mo-V-Cb-Ca钢已经作为高温高压加氢反应器的材料被发展起来了,这些Cr-Mo-V-Cb-Ca钢由于加了V在高温下有着很高的强度,同时附加的大约o.25%的V还能显著提高高温下抗氢蚀和抗氢脆的能力,附加的Ca也是这种材料独有的特征,它能有效降低焊件热影响区产生再热裂纹的可能性,另外通过附加的V还能减少焊件再热裂纹的灵敏度.虽然采用3Cr-1Mo-V-Cb-Ca钢的加氢反应器已经制造成功了,但本文讨论的是第一次采用2.25Cr-1Mo-V-Cb-Ca钢来制造加氢反应器,而且和ASME规范实例2098比较,我们还取得了这种材料的大量的性能数据.另外,对于传统的探伤技术,我们引荐了一种飞行时间衍射(Time-of-Flight Diffraction)(TOFD)技术来对焊件进行超声波探伤,进一步保证了检测手段的可靠性.

  15. An alternative structure of Pu4O9 (''PuO2.25'') incorporating interstitial hydroxyl rather than oxide

    Bond length/bond strength relationships are applied to the Pu4O9 ('PuO2.25') structure proposed by others and support one Pu(V) with a central hydroxyl ion but not a central oxide ion nor formation of Pu(VI). Bond distances and bond strengths are normal for a central ion of unit charge, and reconcile the finding that cell dimensions are so minimally changed from those of PuO2. Substitution of hydroxyl for oxide accounts for the 'excess' oxygen content of PuO2.265, yielding PuO2(OH)0.249. The short range, local order (structure) of the 'Pu4O9' entity is alternatively formulated as Pu4O8OH

  16. Intergranular Cracking Susceptibility of 2.25Cr Heat-Resistant Steels Depending on Alloying Elements and Impurities

    Sung, Hyun Je; Heo, Nam Hoe; Kim, Sung-Joon

    2016-05-01

    The intergranular cracking susceptibility of 2.25Cr heat-resistant steels increases with increasing bulk phosphorus content. This is due to the increase in phosphorus segregation concentration of prior austenite grain boundaries (PAGBs) and the prior austenite grain boundary/carbide interfaces (GCIs) with increasing bulk phosphorus content. Moreover, the susceptibility is higher in tungsten-added steels than the molybdenum-added steel. This is attributed to the higher driving force for carbide formation of tungsten which causes more active carbide formation in the tungsten-added steel, the consequent absence of the repulsive segregation between carbon and phosphorus, and the final higher phosphorus segregation concentration at the PAGBs and the GCIs. Additionally, the absence of sulfur segregation at the PAGBs and the GCIs of the molybdenum-added steel, which arises from the repulsive segregation between carbon and sulfur, acts as an additional factor which lowers the intergranular cracking susceptibility.

  17. The effect of hydrostatic pressure on the creep life of a 2.25% Cr1% Mo Steel

    The effect of superimposed hydrostatic pressures on the creep life of a 2.25% Cr 1% Mo steel, with a bainitic microstructure, is examined. Creep tests have been carried out at 923K with uniaxial stresses in the range 55 to 80 MPa and superimposed hydrostatic pressures up to 35 MPa. Optical and scanning electron microscopy have been used to evaluate the contribution of the hydrostatic stress to grain boundary cavitation. Increasing the hydrostatic pressure for a given uniaxial stress suppresses cavitation, but little changes the secondary creep rate, thereby excending the creep life. Furthermore, the time to failure depends on both the applied uniaxial stress and the hydrostatic pressure and not simply the principal stress. (orig.)

  18. Multiconfiguration Dirac-Hartree-Fock calculations of atomic electric dipole moments of 225^Ra, 199^Hg, and 171^Yb

    Radziute, Laima; Jonsson, Per; Biero, Jacek

    2013-01-01

    The multiconfiguration Dirac-Hartree-Fock (MCDHF) method has been employed to calculate atomic electric dipole moments (EDM) of 225^Ra, 199^Hg, and 171^Yb. For the calculations of the matrix elements we extended the relativistic atomic structure package GRASP2K. The extension includes programs to evaluate matrix elements of (P, T)-odd e-N tensor-pseudotensor and pseudoscalar-scalar interactions, the atomic electric dipole interaction, the nuclear Schiff moment, and the interaction of the electron electric dipole moment with nuclear magnetic moments. The interelectronic interactions were accounted for through valence and core-valence electron correlation effects. The electron shell relaxation was included with separately optimised wave functions of opposite parities.

  19. UNVEILING A NETWORK OF PARALLEL FILAMENTS IN THE INFRARED DARK CLOUD G14.225–0.506

    We present the results of combined NH3 (1,1) and (2,2) line emission observed with the Very Large Array and the Effelsberg 100 m telescope of the infrared dark cloud G14.225–0.506. The NH3 emission reveals a network of filaments constituting two hub-filament systems. Hubs are associated with gas of rotational temperature Trot ∼ 15 K, non-thermal velocity dispersion σNT ∼ 1 km s–1, and exhibit signs of star formation, while filaments appear to be more quiescent (Trot ∼ 11 K and σNT ∼ 0.6 km s–1). Filaments are parallel in projection and distributed mainly along two directions, at P.A. ∼ 10° and 60°, and appear to be coherent in velocity. The averaged projected separation between adjacent filaments is between 0.5 pc and 1 pc, and the mean width of filaments is 0.12 pc. Cores within filaments are separated by ∼0.33 ± 0.09 pc, which is consistent with the predicted fragmentation of an isothermal gas cylinder due to the sausage-type instability. The network of parallel filaments observed in G14.225–0.506 is consistent with the gravitational instability of a thin gas layer threaded by magnetic fields. Overall, our data suggest that magnetic fields might play an important role in the alignment of filaments, and polarization measurements in the entire cloud would lend further support to this scenario.

  20. UNVEILING A NETWORK OF PARALLEL FILAMENTS IN THE INFRARED DARK CLOUD G14.225-0.506

    Busquet, Gemma [INAF-Istituto di Astrofisica e Planetologia Spaziali, via Fosso del Cavaliere 100, I-00133 Roma (Italy); Zhang, Qizhou; Ho, Paul T. P. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Palau, Aina; Girart, Josep M. [Institut de Ciencies de l' Espai (CSIC-IEEC), Campus UAB, Facultat de Ciencies, Torre C-5 parell, E-08193 Bellaterra, Catalunya (Spain); Liu, Hauyu Baobab [Academia Sinica Institute of Astronomy and Astrophysics, Taipei, Taiwan (China); Sanchez-Monge, Alvaro [INAF, Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-05125 Firenze (Italy); Estalella, Robert [Departament d' Astronomia i Meteorologia, Institut de Ciencies del Cosmos (ICC), Universitat de Barcelona (IEEC-UB), Marti i Franques 1, E-08028 Barcelona, Catalunya (Spain); De Gregorio-Monsalvo, Itziar [European Southern Observatory, Karl-Schwarzschild-Strasse 2, D-85748 Garching (Germany); Pillai, Thushara [Caltech Astronomy Department, MC 249-17, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Wyrowski, Friedrich [Max-Planck-Institut fuer Radioastronomie, Auf dem Huegel 69, D-53121 Bonn (Germany); Santos, Fabio P.; Franco, Gabriel A. P., E-mail: gemma.busquet@iaps.inaf.it [Departamento de Fisica-ICEx-UFMG, Caixa Postal 702, 30.123-970 Belo Horizonte-MG (Brazil)

    2013-02-20

    We present the results of combined NH{sub 3} (1,1) and (2,2) line emission observed with the Very Large Array and the Effelsberg 100 m telescope of the infrared dark cloud G14.225-0.506. The NH{sub 3} emission reveals a network of filaments constituting two hub-filament systems. Hubs are associated with gas of rotational temperature T{sub rot} {approx} 15 K, non-thermal velocity dispersion {sigma}{sub NT} {approx} 1 km s{sup -1}, and exhibit signs of star formation, while filaments appear to be more quiescent (T{sub rot} {approx} 11 K and {sigma}{sub NT} {approx} 0.6 km s{sup -1}). Filaments are parallel in projection and distributed mainly along two directions, at P.A. {approx} 10 Degree-Sign and 60 Degree-Sign , and appear to be coherent in velocity. The averaged projected separation between adjacent filaments is between 0.5 pc and 1 pc, and the mean width of filaments is 0.12 pc. Cores within filaments are separated by {approx}0.33 {+-} 0.09 pc, which is consistent with the predicted fragmentation of an isothermal gas cylinder due to the {sup s}ausage{sup -}type instability. The network of parallel filaments observed in G14.225-0.506 is consistent with the gravitational instability of a thin gas layer threaded by magnetic fields. Overall, our data suggest that magnetic fields might play an important role in the alignment of filaments, and polarization measurements in the entire cloud would lend further support to this scenario.

  1. 12 CFR 225.136 - Utilization of foreign subsidiaries to sell long-term debt obligations in foreign markets and to...

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Utilization of foreign subsidiaries to sell long-term debt obligations in foreign markets and to transfer the proceeds to their United States... CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.136 Utilization...

  2. 40 CFR 1045.225 - How do I amend my application for certification to include new or modified engines or change an FEL?

    2010-07-01

    ... a certificate of conformity, you may start producing the new or modified engine configuration...-IGNITION PROPULSION MARINE ENGINES AND VESSELS Certifying Engine Families § 1045.225 How do I amend my... certificate of conformity, you may amend your application to include new or modified engine...

  3. Structures of bulk amorphous Zr41Ti14Ni10Cu12.5Be22.5 alloy in amorphous, crystalline, supercooled liquid and liquid states

    2002-01-01

    The amorphous and crystal structures of Zr41Ti14Ni10Cu12.5Be22.5 alloy have been analyzed with X-ray diffractometer. The structures of bulk amorphous Zr41Ti14Ni10Cu12.5B22.5 alloy in solid, supercooled liquid and liquid states are almost of the same structure. The RDFs (Radius Distribution Function), the first coordination number, the first coordination radius, the correlation radius and atom number of the cluster were calculated for bulk amorphous Zr41Ti14Ni10Cu12.5B22.5 alloy in different states. The first coordination sphere radii and the first coordination numbers are 0.312nm, 11.2 in solid state, 0.301nm, 10.932 in supercooled liquid region and 0.305nm, 11.296 in liquid state. The crystal structure of Zr41Ti14Ni10Cu12.5B22.5 alloy is consisted of several intermetallic compounds which are CuZr2, Be2Zr, etc. The reason of formation glass for this alloy is that there is a larger resistance for atoms to rearrange and form intermetallic compounds in a long range order.

  4. Crystallization in Zr41.2Ti13.8Cu12.5Ni10Be22.5 bulk metallic glass under pressure

    Jiang, Jianzhong; Zhou, T.J.; Rasmussen, Helge Kildahl;

    2000-01-01

    The effect of pressure on the crystallization behavior of the bulk metallic glass-forming Zr41.2Ti13.8Cu12.5Ni10Be22.5 alloy with a wide supercooled liquid region has been investigated by in situ high-pressure and high-temperature x-ray powder diffraction measurements using synchrotron radiation....

  5. Prospective clinical phase II study of two new indwelling voice prostheses (Provox Vega 22.5 and 20 Fr) and a novel anterograde insertion device (Provox Smart Inserter)

    F.J.M. Hilgers; A.H. Ackerstaff; I. Jacobi; A.J.M. Balm; I.B. Tan; M.W.M. van den Brekel

    2010-01-01

    Objectives/Hypothesis: To assess device life of the new Provox Vega 22.5 and 20 Fr prostheses, to establish whether the optimized airflow characteristics of these devices materialize in better voice characteristics in comparison to Provox2, and to assess the feasibility of voice prosthesis replaceme

  6. Gain-of-function R225W mutation in human AMPKgamma(3 causing increased glycogen and decreased triglyceride in skeletal muscle.

    Sheila R Costford

    Full Text Available BACKGROUND: AMP-activated protein kinase (AMPK is a heterotrimeric enzyme that is evolutionarily conserved from yeast to mammals and functions to maintain cellular and whole body energy homeostasis. Studies in experimental animals demonstrate that activation of AMPK in skeletal muscle protects against insulin resistance, type 2 diabetes and obesity. The regulatory gamma(3 subunit of AMPK is expressed exclusively in skeletal muscle; however, its importance in controlling overall AMPK activity is unknown. While evidence is emerging that gamma subunit mutations interfere specifically with AMP activation, there remains some controversy regarding the impact of gamma subunit mutations. Here we report the first gain-of-function mutation in the muscle-specific regulatory gamma(3 subunit in humans. METHODS AND FINDINGS: We sequenced the exons and splice junctions of the AMPK gamma(3 gene (PRKAG3 in 761 obese and 759 lean individuals, identifying 87 sequence variants including a novel R225W mutation in subjects from two unrelated families. The gamma(3 R225W mutation is homologous in location to the gamma(2R302Q mutation in patients with Wolf-Parkinson-White syndrome and to the gamma(3R225Q mutation originally linked to an increase in muscle glycogen content in purebred Hampshire Rendement Napole (RN- pigs. We demonstrate in differentiated muscle satellite cells obtained from the vastus lateralis of R225W carriers that the mutation is associated with an approximate doubling of both basal and AMP-activated AMPK activities. Moreover, subjects bearing the R225W mutation exhibit a approximately 90% increase of skeletal muscle glycogen content and a approximately 30% decrease in intramuscular triglyceride (IMTG. CONCLUSIONS: We have identified for the first time a mutation in the skeletal muscle-specific regulatory gamma(3 subunit of AMPK in humans. The gamma(3R225W mutation has significant functional effects as demonstrated by increases in basal and AMP

  7. Critical level of intergranular fracture to affect the toughness of embrittled 2.25Cr-1Mo steels

    Islam, M. A.; Knott, J. F.; Bowen, P.

    2004-10-01

    In general, the low-temperature brittle fracture mode of unembrittled ferritic steel is transgranular cleavage. During temper embrittlement, impurity elements, such as sulfur (S), phosphorus (P), antimony (Sb), arsenic (As), and tin (Sn), segregate to prior austenite grain boundaries, which results in a decrease in the grain boundary cohesive strength. As a result, the brittle transgranular cleavage fracture mode changes to intergranular decohesion in association with the decrease in the critical fracture (stress (σ F) as well as the fracture toughness (K). However, the appearance of intergranular facets on the fracture surface does not cause a decrease in the K and σ F values. In this work, quenched and fully tempered 2.25Cr-1Mo steel (in an unembrittled condition that exhibits almost 100% brittle transgranular cleavage fracture) has been embrittled for 24, 96, and 210 h at 520 °C to produce different proportions of intergranular fracture. These unembrittled and embrittled steel specimens were tested to measure K (at -120 and -196 °C) and σ F (at -196 °C). The experimental results and detailed fractographic observations show that the K and σ F values decrease with an increase in the area fraction of intergranular fracture, provided that the area fraction of the intergranular facet on the brittle fracture surface exceeded a certain critical level, approximately 20 22%.

  8. Structure of 3-ketoacyl-(acyl-carrier-protein) reductase from Rickettsia prowazekii at 2.25 Å resolution

    The R. prowazekii 3-ketoacyl-(acyl-carrier-protein) reductase is similar to those from other prokaryotic pathogens but differs significantly from the mammalian orthologue, strengthening its case as a potential drug target. Rickettsia prowazekii, a parasitic Gram-negative bacterium, is in the second-highest biodefense category of pathogens of the National Institute of Allergy and Infectious Diseases, but only a handful of structures have been deposited in the PDB for this bacterium; to date, all of these have been solved by the SSGCID. Owing to its small genome (about 800 protein-coding genes), it relies on the host for many basic biosynthetic processes, hindering the identification of potential antipathogenic drug targets. However, like many bacteria and plants, its metabolism does depend upon the type II fatty-acid synthesis (FAS) pathway for lipogenesis, whereas the predominant form of fatty-acid biosynthesis in humans is via the type I pathway. Here, the structure of the third enzyme in the FAS pathway, 3-ketoacyl-(acyl-carrier-protein) reductase, is reported at a resolution of 2.25 Å. Its fold is highly similar to those of the existing structures from some well characterized pathogens, such as Mycobacterium tuberculosis and Burkholderia pseudomallei, but differs significantly from the analogous mammalian structure. Hence, drugs known to target the enzymes of pathogenic bacteria may serve as potential leads against Rickettsia, which is responsible for spotted fever and typhus and is found throughout the world

  9. Carbide evolution and service life of simulated post weld heat treated 2.25Cr–1Mo steel

    To estimate the service life of the reactor internals made of 2.25Cr–1Mo steel in the high temperature gas-cooled reactor pebble-bed module demonstration plant, creep rupture test was performed on the simulated post weld heat treated steel at 773 K over a range of stress levels 300–200 MPa. It has been shown that the rupture time is 126–5532 h, correspondingly. Then, the service life under stress of 161.2 MPa at 648 K was calculated to be so long as 210,374,853 h (≈24,015 years). Four types of carbides M3C, M2C, M7C3 and M23C6 existed in both the steel plate and the post-rupture specimens. As the rupture time increases, the weight percentages of M23C6 and M2C that are stable in thermodynamics in the post-rupture specimens increase while those of metastable M3C and M7C3 decrease on the whole. During the long term creep exposure, the deformation promotes the precipitation of M3C, M2C and M23C6, according to the experimental results with the deformed and undeformed parts of the post-rupture specimens, but its influence on the weight percentage of M7C3 seems rather complicated

  10. Unveiling a network of parallel filaments in the Infrared Dark Cloud G14.225-0.506

    Busquet, Gemma; Palau, Aina; Liu, Hauyu Baobab; Sánchez-Monge, Álvaro; Estalella, Robert; Ho, Paul T P; de Gregorio-Monsalvo, Itziar; Pillai, Thushara; Wyrowski, Friedrich; Girart, Josep M; Santos, Fábio P; Franco, Gabriel A P

    2012-01-01

    We present the results of combined NH3(1,1) and (2,2) line emission observed with the Very Large Array and the Effelsberg 100m telescope of the Infrared Dark Cloud G14.225-0.506. The NH3 emission reveals a network of filaments constituting two hub-filament systems. Hubs are associated with gas of rotational temperature Trot \\sim 25 K, non-thermal velocity dispersion ~1.1 km/s, and exhibit signs of star formation, while filaments appear to be more quiescent (Trot \\sim 11 K, non-thermal velocity dispersion ~0.6 km/s). Filaments are parallel in projection and distributed mainly along two directions, at PA \\sim 10 deg and 60 deg, and appear to be coherent in velocity. The averaged projected separation between adjacent filaments is between 0.5 pc and 1pc, and the mean width of filaments is 0.12 pc. Cores within filaments are separated by ~0.33 pc, which is consistent with the predicted fragmentation of an isothermal gas cylinder due to the 'sausage'-type instability. The network of parallel filaments observed in G...

  11. Laser-trapping of {sup 225}Ra and {sup 226}Ra with repumping by room-temperature blackbody radiation.

    Guest, J. R.; Scielzo, N. D.; Ahmad, I.; Bailey, K.; Greene, J. P.; Holt, R. J.; Lu, Z.-T.; O' Connor, T. P.; Potterveld, D. H.; Physics; Enrico Fermi Inst.; Univ. of Chicago

    2007-02-27

    We have demonstrated Zeeman slowing and capture of neutral {sup 225}Ra and {sup 226}Ra atoms in a magneto-optical trap. The intercombination transition {sup 1}S{sub 0} {yields} {sup 3}P{sub 1} is the only quasicycling transition in radium and was used for laser-cooling and trapping. Repumping along the {sup 3}D{sub 1} {yields} {sup 1}P{sub 1} transition extended the lifetime of the trap from milliseconds to seconds. Room-temperature blackbody radiation was demonstrated to provide repumping from the metastable {sup 3}P{sub 0} level. We measured the isotope shift and hyperfine splittings on the {sup 3}D{sub 1} {yields} {sup 1}P{sub 1} transition with the laser-cooled atoms, and set a limit on the lifetime of the {sup 3}D{sub 1} level based on the measured blackbody repumping rate. Laser-cooled and trapped radium is an attractive system for studying fundamental symmetries.

  12. Containerless solidification of Zr41Ti14Cu12.5Ni10Be22.5 glass-forming alloy in drop tube

    2002-01-01

    Droplets of Zr41Ti14Cu12.5Ni10Be22.5 glass form-ing alloys with different sizes are solidified in a drop tubecontainerless processing. Glass transition behavior, crystal-lization kinetics, and the phase evolution during annealing of the Zr41Ti14Cu12.5Ni10Be22.5 glassy spheres are investigated. The experimental results indicate that the apparent activation energy of the glass transition (Eg = 435.5 kJ/mol), and the activation energy of the main crystallization reaction (Ep1 = 249.6 kJ/mol) are obviously different from those of bulk glass samples prepared by water quenched (Eg = 559.1 kJ/mol and Ep1 =192.5 kJ/mol). The difference is discussed in the view point of the atomic configuration of the liquid state of the metallic glass and nucleation mechanism.

  13. 我国内地49家企业入围ENR2007年度全球国际承包商225

    2007-01-01

    8月16日,美国麦格劳·希尔公司(McGraw Hill)在其网站正式发布了2007年度ENR全球最大225家国际承包商排名,我国内地共有49家企业榜上有名,具体排序如下:

  14. The investigation of the decay of the deformed 167Yb, 164Tm, 225Ac, 221Fr nuclei. Beta-spectrograph with positional-sensitive detector

    The decay of the deformed 167Yb, 164Tm, 225Ac,221Fr nuclei is investigated in this work. For 167Yb and 164Tm decays the specters of the conversion electrons were measured. 32 γ-transitions were found for 167 Yb decay, 6 of which were found for the first time. The multipolarities for 9 γ-transitions were found. For 164Tm decay 23 new γ-transitions were found. The theoretical investigations of the collective states in the nucleus were carried out. Octupole-rotatory line with k=1- was found in the measurement of conversion electrons specters of the short-life nuclei. Device' nonlinearity was 0,04%. Resolution was Δβρ/βρ 0,11%. Effective light yield was 1-2 %. The decay of 225Ac and 221Fr nuclei were investigated. The investigations of α-γ -coincidence, α-γ - rays were carried out. 24 new γ -transitions for 225Ac and 13 ones for 221Fr were found. The new levels and their intensities were defined more precisely. Intensity balance calculations were carried out and the full populations of the nuclear levels were calculated. (author). 3 tabs.; 10 figs

  15. Field Test Report: Preliminary Aquifer Test Characterization Results for Well 299-W15-225: Supporting Phase I of the 200-ZP-1 Groundwater Operable Unit Remedial Design

    Spane, Frank A.; Newcomer, Darrell R.

    2009-09-23

    This report examines the hydrologic test results for both local vertical profile characterization and large-scale hydrologic tests associated with a new extraction well (well 299-W15-225) that was constructed during FY2009 for inclusion within the future 200-West Area Groundwater Treatment System that is scheduled to go on-line at the end of FY2011. To facilitate the analysis of the large-scale hydrologic test performed at newly constructed extraction well 299-W15-225 (C7017; also referred to as EW-1 in some planning documents), the existing 200-ZP-1 interim pump-and-treat system was completely shut-down ~1 month before the performance of the large-scale hydrologic test. Specifically, this report 1) applies recently developed methods for removing barometric pressure fluctuations from well water-level measurements to enhance the detection of hydrologic test and pump-and-treat system effects at selected monitor wells, 2) analyzes the barometric-corrected well water-level responses for a preliminary determination of large-scale hydraulic properties, and 3) provides an assessment of the vertical distribution of hydraulic conductivity in the vicinity of newly constructed extraction well 299-W15-225. The hydrologic characterization approach presented in this report is expected to have universal application for meeting the characterization needs at other remedial action sites located within unconfined and confined aquifer systems.

  16. Structural characterization of the epitopes of the monoclonal antibodies 473HD, CS-56, and MO-225 specific for chondroitin sulfate D-type using the oligosaccharide library.

    Ito, Yumi; Hikino, Megumi; Yajima, Yuki; Mikami, Tadahisa; Sirko, Swetlana; von Holst, Alexer; Faissner, Andreas; Fukui, Shigeyuki; Sugahara, Kazuyuki

    2005-06-01

    The variation in the sulfation profile of chondroitin sulfate (CS)/dermatan sulfate (DS) chains regulates central nervous system development in vertebrates. Notably, the disulfated disaccharide D-unit, GlcUA(2-O-sulfate)-GalNAc(6-O-sulfate), correlates with the promotion of neurite outgrowth through the DSD-1 epitope that is embedded in the CS moiety of the proteoglycan DSD-1-PG/phosphacan. Monoclonal antibody (mAb) 473HD inhibits the DSD-1-dependent neuritogenesis and also recognizes shark cartilage CS-D, which is characterized by the prominent D-unit and is also recognized by two other mAbs, CS-56 and MO-225. We investigate the oligosaccharide epitope structures of these CS-D-reactive mAbs by ELISA and oligosaccharide microarrays using lipid-derivatized CS oligosaccharides. CS-56 and MO-225 recognized the octa- and larger oligosaccharides, though the latter also bound one unique hexasaccharide D-A-D, where A denotes the disaccharide A-unit GlcUA-GalNAc(4-O-sulfate). The octasaccharides reactive with CS-56 and MO-225 shared a core A-D tetrasaccharide, whereas the neighboring structural elements located on the reducing and/or nonreducing sides of the A-D gave a differential preference additionally to the recognition sequence for each antibody. In contrast, 473HD reacted with multiple hexa- and larger oligosaccharides, which also contained A-D or D-A tetrasaccharide sequences. Consistent with the distinct specificity of 473HD as compared with CS-56 and MO-225, the 473HD epitope displayed a different expression pattern in peripheral mouse organs as revealed by immunohistology, extending the previously reported CNS-restricted expression. The epitope of 473HD, but not of CS-56 or MO-225, was eliminated from DSD-1-PG by digestion with chondroitinase B, suggesting the close association of L-iduronic acid with the 473HD epitope. Despite such supplemental information, the integral epitope remains to be isolated for identification and comprehensive analytical

  17. Stress-assisted hydrogen attack cracking in 2.25Cr-1Mo steels at elevated temperatures

    Crack growth in 2.25Cr-1Mo steels exposed to 3,000 psi hydrogen has been investigated in the temperature range 440 C to 500 C, using modified wedge-opening loaded specimens to vary stress intensity. Under conditions of temperature and hydrogen pressure, where general hydrogen attack does not occur, the crack propagated by the growth and coalescence of a high density of methane bubbles on grain boundaries, driven by the synergistic influence of internal methane pressure and applied stress. Crack growth rates were measured in base metal, and the heat-affected zones (HAZs) of welds were tempered to different strength levels. The crack growth rate increased with material strength. Above a threshold of about Kl = 20 MPa√m (at 480 C), the crack growth rate increased rapidly with stress intensity, increasing as roughly Kl6.5. Because of better creep resistance, stronger materials can sustain higher levels of stress intensity to drive crack growth and nucleate the high density of voids necessary for crack growth. Stress relaxation by creep reduces the stress intensity, and thus the growth rate, especially in weaker materials. The crack growth rate in the heat-affected zone was found to be substantially faster than in the base metal of the welds. Analysis indicates that Kl rather than C* is the appropriate crack-tip loading parameter in the specimen used here and in a thick-walled pressure vessel. The DC potential drop technique met with limited success in this application due to the spatially discontinuous manner of crack growth and limited crack-tip opening displacement

  18. Experimental information: 225 [RED

    Full Text Available 2202_21_1_2 RED Cy3 Cy3 Masaaki Umeda The University of Tokyo Cell ... cycle Transgenic Cell ... cycle T ... ransgenic cell ... division,cell ... cycle,cyclin,CDK,transgenic plant on ...

  19. Case 225: Leiomyoma.

    DiPoce, Jason; Liu-Jarin, Xiaolin; Newhouse, Jeffrey

    2016-01-01

    A 33-year-old pregnant woman (gravida 11, para 8) presented with increasing severe abdominal pain during the first trimester of pregnancy and increasing abdominal distention out of proportion to her prior pregnancies. Ultrasonography (US) without Doppler performed at another hospital had revealed a pelvic mass; therefore, this patient had been referred to our institution for further evaluation. Unenhanced magnetic resonance (MR) imaging was then performed at 8 weeks of gestation. The main portion of the gravid uterus and the ovaries was not seen on these images, but the parts that were seen appeared normal. Diagnostic laparoscopic biopsy was performed during the first trimester, but complete removal of the mass was deferred because of fears the pregnancy would be lost. The patient was closely observed throughout the pregnancy with serial US until the 37th week of gestation, at which time the patient underwent Caesarian section. At the time of Caesarian section, the mass was noted to extend from the spleen downward deep into the pelvis. A biopsy was performed at the time of Caesarian section. Definitive removal of the mass was deferred at the time of Caesarian section to minimize postpartum blood loss and to further delineate the mass with imaging for future surgery. Intravenous contrast material-enhanced (120 mL of Omnipaque 350; Nycomed Amersham, Princeton, NJ) computed tomography (CT) was performed 3 days after Caesarian section. The cystic component measured approximately 15 HU. Repeat MR imaging 1.5 months after Caesarian section was then performed. No loss of signal intensity in the mass was seen on fat-saturated images. There was no evidence of local or distant metastatic disease. The mass abutted and displaced the uterus and the ovaries but did not distort either of these organs. Vascular anatomy was not useful in determining the origin of the mass. The comprehensive metabolic panel and complete blood count were normal throughout and after the pregnancy. PMID:26690995

  20. Comment: 225 [Taxonomy Icon

    Full Text Available .1 Japan ヨコヅナクマムシ 電子顕微鏡写真 撮影:行弘文子(農業生物資源研究所)、堀川大樹(NASA Ames Research Center) bando 2010/02/15 14:55:04 2010/02/16 10:43:01 ...

  1. Novel BAC mouse model of Huntington’s disease with 225 CAG repeats exhibits an early widespread and stable degenerative phenotype

    Wegrzynowicz, Michal; Bichell, Terry Jo; Soares, Barbara D.; Loth, Meredith K.; McGlothan, Jennifer L.; Alikhan, Fatima S.; Hua, Kegang; Coughlin, Jennifer M.; Holt, Hunter K.; Jetter, Christopher S.; Mori, Susumu; Pomper, Martin G.; Osmand, Alexander P.; Guilarte, Tomás R.; Bowman, Aaron B.

    2015-01-01

    BACKGROUND Unusually large CAG repeat expansions (>60) in exon one of Huntingtin (HTT) are invariably associated with a juvenile-onset form of Huntington’s disease (HD), characterized by a more extensive and rapidly progressing neuropathology than the more prevalent adult-onset form. However, existing mouse models of HD that express the full-length Htt gene with CAG repeat lengths associated with juvenile HD (ranging between ~75 to ~150 repeats in published models) exhibit selective neurodegenerative phenotypes more consistent with adult-onset HD. OBJECTIVE To determine if a very large CAG repeat (>200) in full-length Htt elicits neurodegenerative phenotypes consistent with juvenile HD. METHODS Using a bacterial artificial chromosome (BAC) system, we generated mice expressing full-length mouse Htt with ~225 CAG repeats under control of the mouse Htt promoter. Mice were characterized using behavioral, neuropathological, biochemical and brain imaging methods. RESULTS BAC-225Q mice exhibit phenotypes consistent with a subset of features seen in juvenile-onset HD: very early motor behavior abnormalities, reduced body weight, widespread and progressive increase in Htt aggregates, gliosis, and neurodegeneration. Early striatal pathology was observed, including reactive gliosis and loss of dopamine receptors, prior to detectable volume loss. HD-related blood markers of impaired energy metabolism and systemic inflammation were also increased. Aside from an age-dependent progression of diffuse nuclear aggregates at 6 months of age to abundant neuropil aggregates at 12 months of age, other pathological and motor phenotypes showed little to no progression. CONCLUSIONS The HD phenotypes present in animals 3 to 12 months of age make the BAC-225Q mice a unique and stable model of full-length mutant Htt associated phenotypes, including body weight loss, behavioral impairment and HD-like neurodegenerative phenotypes characteristic of juvenile-onset HD and/or late-stage adult

  2. CONDENSED MATTER: ELECTRONIC STRUCTURE, ELECTRICAL, MAGNETIC, AND OPTICAL PROPERTIES: Cavity design and linear analysis of 225 GHz frequency-quadrupling gyroklystron

    Liu, Di-Wei; Yuan, Xue-Song; Yan, Yang; Liu, Sheng-Gang

    2009-07-01

    This paper considers the frequency-quadrupling three-cavity gyroklystrons with successive frequency-doubling in each cavity. The cavities of 225 GHz frequency-quadrupling gyroklystron are designed with the scattering matrices method and the possible operating mode are discussed. With the point-gap theory, the starting currents of the possible operating modes and the potential parasitic modes in the output cavity are calculated. The optimal operating mode is proposed under consideration of the mode competition and the power capacity of the cavity.

  3. Energy dependence of volume integral and mean square radii (MSR) for elastic scattering of neutrons from 40Ca at 65 - 225 MeV

    We describe our results for the calculated neutron-nucleus optical potential in the energy region 65-200 MeV for the scattering of neutrons from 40Ca, in first order Brueckner theory, using both the Urbana v -14 soft-core and Hamada - Johnston (HJ) hard-core interactions. The corresponding results are denoted by UB and HJ respectively. We have made a systematic study of energy dependence of Mean Square Radii and the volume integrals of the Optical model potentials. We have also used Hamada-Johnston realistic interaction for n- 40Ca in the energy region 65 to 225 MeV

  4. Fe2+-Tetracycline-Mediated Cleavage of the Tn10 Tetracycline Efflux Protein TetA Reveals a Substrate Binding Site near Glutamine 225 in Transmembrane Helix 7

    McMurry, Laura M.; Aldema-Ramos, Mila L.; Levy, Stuart B.

    2002-01-01

    TetA specified by Tn10 is a class B member of a group of related bacterial transport proteins of 12 transmembrane alpha helices that mediate resistance to the antibiotic tetracycline. A tetracycline-divalent metal cation complex is expelled from the cell in exchange for a entering proton. The site(s) where tetracycline binds to this export pump is not known. We found that, when chelated to tetracycline, Fe2+ cleaved the backbone of TetA predominantly at a single position, glutamine 225 in tra...

  5. Effect of modified postweld heat treatment on disbonding of 2.25 Cr-1 Mo steel overlay welded with austenitic stainless steel

    The susceptibility to disbonding which occurs at the interface of 2.25 Cr-1 Mo steel overlay welded with austenitic stainless steel can be drastically improved by modified postweld heat treatments (Mod PWHT), heat treatment at 963 K for 25.2 ks followed by annealing at 813 K for 54 ks and subsequent air cooling (after overlay welding). Severe disbonding tests under hydrogen atmosphere have revealed that the Mod PWHT steel produced hardly cracks at the interface; whereas, the conventional PWHT steel developed large cracks. This was due to the fact that the Mod PWHT suppresses the appearance of high carbon fresh martensite, which increases the susceptibility to disbonding significantly. (orig.)

  6. The abnormal segregation behavior of solutes under tensile stress and its effect on carbide reactions in 2.25Cr–1.5W heat-resistant steels

    The phosphorus segregation concentration at grain boundary/carbide interfaces of 2.25Cr–1.5W heat-resistant steels under tensile stress shows a broad convex profile in a log time versus segregation concentration plot. The decrease in phosphorus segregation concentration after the maximum in the convex profile is due to the formation of new equilibrium MC carbides on the surface of the pre-formed M23C6 carbides and its partitioning effect of the phosphorus segregated at the M23C6 carbide interface to the interface of the new MC carbides

  7. Material test data of 2.25Cr-1Mo Steel and Mod.9Cr-1Mo Steel (Set of data)

    小高 進; 加藤 章一; 吉田 英一; 川上 朋広; 鈴木 高一; 高森 裕二; 川島 成一

    2003-01-01

    Matenal tests of 2.25Cr-1Mo Steel and Mod. 9Cr-1Mo Steel, which were used for structure material of fast breeder reactor (FBR) have been preformed in New Technology Development Group. In this report, the result of test obtained up to this time was collected. Many valuable data from long time test for more than 100000 hours including sodium environment test data in this report will be used for material examination of FBR in the future. It creates, in order for for ASME Code Committee to re...

  8. Compression behavior of Zr41Ti14Cu12.5Ni10Be22.5 bulk metallic glass up to 24 GPa

    LI; Gong; ZHAN; Zaiji; LIU; Jing; YUN; Jinku; SUN; Liling; L

    2005-01-01

    The compression of a Zr41Ti14Cu12.5Ni10Be22.5 bulk metallic glass (BMG) is investigated at room temperature up to 24 GPa using in-situ high pressure energy dispersive X-ray diffraction with a synchrotron radiation source. The pressure-induced structural relaxation is exhibited. It is found that below about 8 GPa, the existence of excess free volume contributes to the rapid structural relaxation, which gives rise to the rapid volumetric change, and the structural relaxation results in the structural stiffness under higher pressure.

  9. Thermodynamic Evaluation of Carbide Precipitates in 2.25Crfraction three-quarters 1.0Mo Steel for Determination of Service Degradation

    Marinkovic Bojan A.

    2002-01-01

    Full Text Available The 2.25Crfraction three-quarters1.0Mo steel is widely used in petroleum refining units, for example, in pressure vessels, working under severe operational conditions. Due to the high temperatures of some processes, many phenomena such as precipitation of carbides and their coarsening occur during service, resulting in changes of material microstructure. Such changes may modify the mechanical properties, which are responsible for the performance of the pressure vessels. Using a software for thermodynamic calculations, the thermodynamically stable carbides over the temperature range of interest (700-1040 K were evaluated, supposing ferrite as the original microstructure. The theoretical carbide nucleation sequence was also established. Moreover, the theoretical amount of thermodynamically stable carbides and the fraction of Fe, Cr and Mo in the metallic sublattice of M23C6 were determined as a function of temperature. These theoretical calculations were compared to some experimental results on carbide precipitation in the 2.25Crfraction three-quarters1.0Mo steel and two approaches for evaluating the service degradation were proposed. The first one is based on the amount of precipitated M23C6 and the other on the Fe/Cr ratio in the M23C6 carbide.

  10. Enhancement of physical protection measures and observation on future JAEA's measures reflecting INFCIRC/225/Rev.5 (Draft) under consideration at IAEA

    The revised Nuclear Reactor Regulation Law is aimed at strengthening of the physical protection taking into account of INFCIRC/225/Rev.4 (Corrected) requirements by focusing on introducing confidentiality of secret information concerning the protection of the specific nuclear fuel material, physical protection inspection, and Design Basis Threat (DBT) following latest recommendations by International Atomic Energy Agency (IAEA), enforced in December, 2005. Japan Atomic Energy Agency (JAEA) possesses many facilities using Plutonium that fulfill the requirements of Category I and applicable DBT. In order to respond to the revised law, JAEA has conducted (a) development of information management manual for the reinforcement of the physical protection information control, (b) evaluation of the implementation of physical protection measures based on the DBT presented by the competent authority, and (c) enhancement of physical protection measures based on the evaluation result. Moreover, the inspection of physical protection measures and the verification of compliance with the physical protection regulation by competent authority were conducted for each JAEA facility, and the additional corresponding measures to reflect an inspection result were conducted. In this paper,we brief the requirements for the facility using Plutonium, an overview of the instruction by competent authority, an overview of corresponding measures by JAEA. Furthermore, we describe an image of a future physical protection system of JAEA's plutonium facilities influenced by the enhancement of physical protection measures following the recommendation document for the physical protection of nuclear material and nuclear facilities (INFCIRC/225/Rev.5 (Draft)) currently under consideration by IAEA. (author)

  11. Enhancement of Physical Protection Measures and Observation on Future JAEA's Measures Reflecting INFCIRC/225/Rev.5 (Draft) under Consideration at IAEA

    The revised Nuclear Reactor Regulation Act was aimed at strengthening of the physical protection taking into account of INFCIRC/225/Rev.4 (Corrected) requirements by focusing on introducing confidentiality of secret information concerning the protection of the specific nuclear material, physical protection inspection, and Design Basis Threat (DBT) following latest recommendations by International Atomic Energy Agency (IAEA), enforced in December, 2005. Japan Atomic Energy Agency (JAEA) possesses many facilities using Plutonium that fulfill the requirements of Category I and applicable DBT. In order to respond to the revised law, JAEA has conducted (a) development of information management manual for the reinforcement of the physical protection information control, (b) evaluation of the implementation of physical protection measures based on the DBT presented by the competent authority, and (c) enhancement of physical protection measures based on the evaluation result. Moreover, the inspection of physical protection measures and the verification of compliance with the physical protection regulation by competent authority were conducted for each JAEA facility, and the additional corresponding measures to reflect an inspection result were conducted. In this paper, we brief the requirements for the facility using Plutonium, an overview of the instruction by competent authority, an overview of corresponding measures by JAEA. Furthermore, we describe an image of a future physical protection system of JAEA's plutonium facilities influenced by the enhancement of physical protection measures following the recommendation document for the physical protection of nuclear material and nuclear facilities (INFCIRC/225/Rev.5 (Draft)) currently under consideration by IAEA. (author)

  12. Numerical analysis on the distrubution of welding residual stresses in 2.25Cr-1Mo steel welds by welding heat sources

    The continuous studies for the material properties of Cr-Mo steel being used for the high pressure vessel at medium high temperature condition in electric power generation facilities are being conducted, because of the excellent thermal, pressure and corrosion resistance. But the only verified welding processes have been applied mainly so far, due to the specific reasons in electric power industries. But when it comes to the development of various welding heat sources and their application for the high quality welds and the productivity, the various researches have been being conducted recently in developed countries. And, in this study, in order to verify the application possibility of the laser welding process to the 2.25Cr-1Mo steel, it is intended to compare with and inquire into the characteristics of residual stresses distribution in welds by arc and laser welding using the finite element method. As the result of numerical analysis, the fact that the laser welding process has a benefit in respect to the residual stress distribution has been found out, and the application possibility of the laser welding process to the 2.25Cr-1Mo steel has been found out as well in respect to the mechanical characteristics in welds

  13. Study on the mechanism of de-embrittlement based on the theory of grain boundary segregation for 2.25Cr-1Mo steel

    Research highlights: → Mechanism of embrittlement and de-embrittlement for 2.25Cr-Mo steel was studied. → The critical temperature of embrittlement for embrittled material was proposed firstly. → Segregation model that element P segregates to intragranular from grain boundary was deduced. → Auger electron spectroscopy analysis were conducted for hydrogenation reactor after 12 years. → Discussing de-embrittled process and method of embrittled heat treating. - Abstract: The mechanism of embrittlement and de-embrittlement for 2.25Cr-1Mo steel was studied based on the theory of grain boundary segregation, and the idea of critical temperature of embrittlement for embrittled material was proposed according to the iso-segregation curve in this paper. There is one critical embrittlement temperature corresponding to each degree of embrittlement. When further heat treating temperature is higher than critical temperature, it is a de-embrittlement process. Otherwise, it is an embrittlement process. The model of segregation that element P segregates to intragranular from grain boundary in the de-embrittlement process was deduced based on the theory of atom diffusion. The de-embrittled test and Auger electron spectroscopy analysis were conducted for the matrix of hydrogenation reactor served for 12 years, and the theoretical calculation is consistent with the experimental results, which indicates that the further embrittlement or de-embrittlement mechanism can be explained both qualitatively and quantitatively with combination of the theory of iso-segregation curve and the de-embrittled model derived.

  14. Structure and Properties of the Hardmetal Coatings Cr3C2-25NiCr Formed by a Multi-chamber Detonation Sprayer

    Kovaleva M.G.

    2015-01-01

    Full Text Available The hardmetal Cr3C2-25NiCr (180-220 μm thick coatings have been produced on a steel substrate by a multi-chamber detonation sprayer (MCDS. The characteristic feature of MCDS is that the powder is accelerated by using combustion products that are formed in MCDS chambers and are converged before entering the nozzle, where they interact with the two-phase gas-powder cloud. The microstructures and properties of the hardmetal coatings were examined with the use of optical microscopy, scanning electron microscopy, X-ray phase analysis, and a Vickers hardness tester with a 300 g test load. Wear tests were carried out using a computer controlled pin-on-disc type tribometer. It was established that MCDS has provided the conditions for formation of a dense hardmetal Cr3C2-25NiCr (180-220 μm thick coatings with a porosity of less than 0.02%, microhardness 540±210 HV0.3 and a specific wear rate of 9.08∙10-5 mm3(m∙N-1.

  15. Level structure of 217Rn and 221Ra investigated in the alpha-decay 225Th → 221Ra → 217Rn

    The nuclei 221Ra and 217Rn have been investigated in the α-decay chain 225Th → 221Ra → 217Rn through γ-ray and conversion-electron studies. The short-lived 225Th nuclei (T1/2=8 min) were produced in the 226Ra(α, 5n) reaction, and γ-rays and conversion electrons were measured - between the irradiation periods - in coincidence with α-particles. In 221Ra the five lowest levels are interpreted as members of a K=5/2 parity-doublet with ΔEπ=104 keV. These levels, as well as a higher-lying Kπ=3/2+ band, are consistent with an octupole deformation of 221Ra, as expected from theoretical considerations. In 217Rn only three excited levels are observed, with a favoured α-decay to a 5/2+ excited level thus establishing positive parity for the ground state of 221Ra. (orig.)

  16. System for recovery of daughter isotopes from a source material

    Tranter, Troy J [Idaho Falls, ID; Todd, Terry A [Aberdeen, ID; Lewis, Leroy C [Idaho Falls, ID; Henscheid, Joseph P [Idaho Falls, ID

    2009-08-04

    A method of separating isotopes from a mixture containing at least two isotopes in a solution is disclosed. A first isotope is precipitated and is collected from the solution. A daughter isotope is generated and collected from the first isotope. The invention includes a method of producing an actinium-225/bismuth-213 product from a material containing thorium-229 and thorium-232. A solution is formed containing nitric acid and the material containing thorium-229 and thorium-232, and iodate is added to form a thorium iodate precipitate. A supernatant is separated from the thorium iodate precipitate and a second volume of nitric acid is added to the thorium iodate precipitate. The thorium iodate precipitate is stored and a decay product comprising actinium-225 and bismuth-213 is generated in the second volume of nitric acid, which is then separated from the thorium iodate precipitate, filtered, and treated using at least one chromatographic procedure. A system for producing an actinium-225/bismuth-213 product is also disclosed.

  17. Analysis of elevated temperature flow and work hardening behaviour of service-exposed 2.25Cr-1Mo steel using Voce equation

    The Voce equation was used to model the tensile flow and work-hardening behaviour of a service-exposed 2.25Cr-1Mo steel. The applicability of Voce parameters obtained from the fit to experimental true stress-true strain datasets for estimating the validity of the fit was examined. The Voce equation was found to model the stress-strain curve closely. The Voce parameter nv was correlated to the underlying dislocation activities. It was found that the values of Voce parameters at various temperatures and strain rates can be used to infer the operating recovery mechanism during stage III hardening. A low absolute value of nv is indicative of recovery by cross-slip, whereas the high temperature transition to climb or sub-boundary migration driven recovery is accompanied by an increase in the value of nv

  18. Deformation of Zr41 Ti14 CU12.5 Ni10 Be22.5 bulk amorphous alloy under isobaric pressure in super-cooled liquid region

    ZHANG Ke-qin; LU Qi-zhu

    2005-01-01

    The curve of crystallization transition during continuous heating for the Zr41Ti14Cu12.5Ni10Be22.5 bulk amorphous alloy was measured by means of dilatation(Fully automatic transformation recording/measuring instrument) and X-ray diffraction(XRD) method. The deformation behavior of the alloy at various heating rates in the supercooled liquid region was studied. The results show that the glass transition temperature of the alloy increases slightly and the supercooled liquid region(SLR) increases significantly with increasing heating rate. The deformation amount under isobaric pressure of 1 N for the alloy in the SLR increases with increasing heating rate. As the heating rate of the alloy increases from 5 to 100 ℃/min, the amount of deformation of the alloy increases from 8.3% to 45%.

  19. High-Temperature Corrosion Behavior of Different Regions of Weldment of 2.25Cr-1Mo Steel in SO2 + O2 Atmosphere

    Ghosh, D.; Shukla, A. K.; Mitra, S. K.; Satpati, B.

    2016-02-01

    This paper investigates the corrosion behavior of different regions of weldment of 2.25Cr-1Mo steel exposed in mixed oxidation and sulfidation (SO2 + O2) environment up to 500 h at 773 K. Microstructural investigation and characterization of oxide scales are done using SEM, TEM, and XRD. The obtained results infer that heat-affected zone corrodes faster than both base and weld metal. The reaction kinetics follows a parabolic growth rate for all regions. The higher corrosion rate of heat-affected zone is attributed to the formation of Cr23C6 secondary precipitates leading to depletion of protective inner scale of the Cr-rich oxide during welding.

  20. Analysis of the nature of excessive cosmic radiation in the area of the Brazilian magnetic anomaly at altitudes 250-500km, from Kosmos-225 satellite data

    Raychenko, L. V.

    1974-01-01

    Results are presented from a study of the region of anomalous cosmic radiation in the area of the Brazilian magnetic anomaly at the altitudes 250-500 km, using data measurements taken on the Kosmos-225 satellite (14-29 June 1968). The existence of a stable intensity anomaly discovered in the experiments on the second and third Soviet spacecraft-satellites is confirmed. The total vector of the geomagnetic field at different altitudes was compared with isoline maps. An altitude profile of the South Atlantic anomaly of radiation intensity was obtained, using data from the same instrument. The nature of the anomalies in cosmic radiation intensity over the regions of negative magnetic anomalies is discussed.

  1. Use of Radioactive Ion Beams for Biomedical Research 1. in vivo labelling of monoclonal antibodies with radio-lanthanides and $^{225}$Ac

    2002-01-01

    % IS330 \\\\ \\\\\\begin{enumerate} \\item The aim of this study was to contribute to developments of new radiopharmaceuticals for tumour diagnosis and therapy. CERN-ISOLDE is the leading facility in the world to provide radioactive ion beams with high selectivity, purity and intensity. Radioisotope production by spallation makes available a complete range of rare earth isotopes having as complete a diversity of types and energy of radiation, of half-life, and of ionic properties as one would wish. The availability of exotic nuclei, e.g. radionuclides of rare earth elements and $^{225}$Ac, opens new possibilities for the development of radiopharmaceuticals for diagnosis and therapy.\\\\ \\\\ \\item Two approaches were followed within the experimental program. The radioactive metal ions are bound either to bio-specific ligands (monoclonal antibodies or peptides) or to unspecific low molecular weight form. The aim of the experimental program is to evaluate relationships between physico-chemical parameters of the tracer m...

  2. Nanocrystalline grains growth of Zr_(41.2)Ti_(13.8)Ni_(10)Cu_(12.5)Be_(22.5) bulk amorphous alloy in initial stages%Zr_(41.2)Ti_(13.8)Cu_(12.5)Ni_(10)Be_(22.5)块体非晶合金晶化初期纳米晶粒生长

    彭德林

    2010-01-01

    利用电弧熔炼及铜模快速铸造的方法制备Zr_(41.2)Ti_(13.8)Cu_(12.5)Ni_(10)Be_(22.5)块体非晶合金,通过高分辨电子显微镜研究过冷液相区和晶化初期晶核的形成、纳米晶粒长大.结果表明,Zr_(41.2)Ti_(13.8)Ni_(10)Cu_(12.5)Be_(22.5)块体非晶合金晶化初期,利用高分辨像能观察到晶格点阵特征条纹.很难区分过冷液相区内微小区域的结构特征,借助高分辨像的傅里叶变换技术很容易地辨别出晶化前与相分离有关的结构变化.纳米晶粒以聚合型和单独晶核两种方式生长.

  3. Cinética de degradación del naftaleno por células inmovilizadas húmedas de Bacillus alcalophilus cepa IDO-225

    Roberto Rafael Núñez Moreira

    2004-01-01

    Full Text Available Numerosas han sido las investigaciones sobre el estudio de la biorremediación para su aplicación en la lucha para combatir la contaminación ambiental por hidrocarburos. El Instituto de Oceanología del Ministerio de Ciencia, Tecnología y Ambiente, ha trabajado desde 1988 en el aislamiento y conservaci ón de bacterias marinas que sean capaces de degradar el petróleo. Actualmente, cuenta con cuatro bioproductos degradadores de petróleo en medio marino denominados BIOIL, K-BIOIL, BIOIL-FC e IDO-225. En el presente trabajo, se demuestra por Espectroscopia Infrarroja de las muestras extraídas a los 3, 6, 9, 12 y 15 d de contacto de las células húmedas inmovilizadas de Bacillus alcalophilus cepa IDO-225 en el medio de degradación con el naftaleno, un hidrocarburo del petróleo, que estas son capaces de degradar el naflateno como única fuente de carbono y energía. La degradación de este hidrocarburo por las células inmovilizadas de esta cepa se lleva a cabo mediante un mecanismo que se basa en un modelo cinético de segundo orden correspondiente a un mecanismo de metil-oxidación y b-oxidación, al igual que las células libres de dicha cepa, pero con la diferencia de que en el caso de las células inmovilizadas, el término cuadrático (metil-oxidación es mayor y el término lineal (b-oxidación es menor que en las células libres. En este mecanismo se produce acetil-CoA, el cual se incorpora al ciclo de los acidos tricarboxílicos para formar dióxido de carbono, agua y coenzimas reducidas, las cuales se dirigen a la cadena de transporte electrónica para obtener energía en forma de ATP y garantizar la síntesis de compuestos esenciales y la obtención de energía.

  4. 经脐孔腹腔镜阑尾切除术225例临床观察%Clinical research on laparoscopic appendectomy through umbilicus

    符松; 王苏明

    2013-01-01

    Objective To explore the feasibility and therapeutic experience of laparoscopic appendectomy through umbilicus in children. Methods 225 cases of acute appendicitis were treated with umbilical single hole laparoscopic appendectomy. For umbilical 1. 0cm incision, insert two 0. 5cm Trocar insertion forceps injury Profiler abdominal organs to find appendectomy grip appendix tip, the appendix completely pulled out from the umbilical abdominal resection using conventional open appendectomy processing the appendix and its mesentery, the completion of the appendectomy. Results The operative time was 10 to 40min ( 20±6. 55 min). The postoperative exhaust time was 4 to 24h (16±5. 45) h. There was no short-term complications. The abdomen has no incision scar. Conclusion The umbilical single-hole method laparoscopic appendectomy is a simple, effective surgical method in the treatment of pediatric appendicitis and it can make the part appendicitis operation become a cosmetic surgery and to become a part of the appendicitis surgery cosmetic surgery.%目的 探讨经脐部单孔法腹腔镜小儿阑尾切除术的可行性及治疗经验.方法 对225例小儿急性阑尾炎采用脐部单孔法腹腔镜阑尾切除术,并观察其疗效.结果 本组手术时间10~40min,平均(20士6.55)min,术后排气时间4~24h,平均(16士5.45)h.术后切口全部Ⅰ期愈合,无近期并发症.腹部未见切口瘢痕.结论 脐部单孔法腹腔镜阑尾切除术是小儿阑尾炎治疗中简洁、有效的手术方法之一,可使部分阑尾炎手术成为一种美容手术.

  5. Reflection asymmetry in odd-A and odd-odd actinium nuclei

    Theoretical calculations and measurements indicate that octupole correlations are at a maximum in the ground states of the odd-proton nuclei Ac and Pa. It has been expected that odd-odd nuclei should have even larger amount of octupole-octupole correlations. We have recently made measurements on the structure of 224Ac. Although spin and parity assignments could not be made, two bands starting at 354.1 and 360.0 keV have properties characteristic of reflection asymmetric shape. These two bands have very similar rotational constants and also similar alpha decay rates, which suggest similarity between the wavefunctions of these bands. These signatures provide evidence for octupole correlations in these nuclides

  6. Bestimmung der Ionisationsenergie von Actinium und Ultraspurenanalyse von Plutonium mit resonanter Ionisationsmassenspektrometrie (RIMS)

    Waldek, Achim Marcus

    2001-01-01

    ZusammenfassungDie Resonanzionisationsmassenspektrometrie (RIMS) verbindet hohe Elementselektivität mit guter Nachweiseffizienz. Aufgrund dieser Eigenschaften ist die Methode für Ultraspurenanalyse und Untersuchungen an seltenen oder schwer handhabbaren Elementen gut geeignet. Für RIMS werden neutrale Atome mit monochromatischem Laserlicht ein- oder mehrfach resonant auf energetisch hoch liegende Niveaus angeregt und anschließend durch einen weiteren Laserstrahl oder durch ein elektrisches Fe...

  7. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228

    The activities of 228Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide 228Ac. The radium was pre-concentrated on MnO2 and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter 228Ra(228Ac), the daughter nuclide 228Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by 228Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9±0.1% was measured for 228Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317±0.013 cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1 g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of 228Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for 228Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure 228Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used

  8. Linear free energy relationship applied to trivalent cations with lanthanum and actinium oxide and hydroxide structure

    Linear free energy relationships for trivalent cations with crystalline M2O3 and, M(OH)3 phases of lanthanides and actinides were developed from known thermodynamic properties of the aqueous trivalent cations, modifying the Sverjensky and Molling equation. The linear free energy relationship for trivalent cations is as ΔGf,MvX0=aMvXΔGn,M3+0+bMvX+βMvXrM3+, where the coefficients aMvX, bMvX, and βMvX characterize a particular structural family of MvX, rM3+ is the ionic radius of M3+ cation, ΔGf,MvX0 is the standard Gibbs free energy of formation of MvX and ΔGn,M3+0 is the standard non-solvation free energy of the cation. The coefficients for the oxide family are: aMvX=0.2705, bMvX=-1984.75 (kJ/mol), and βMvX=197.24 (kJ/molnm). The coefficients for the hydroxide family are: aMvX=0.1587, bMvX=-1474.09 (kJ/mol), and βMvX=791.70 (kJ/molnm).

  9. Actinium: A RESTful Runtime Container for Scriptable Internet of Things Applications

    Kovatsch, Matthias; Lanter, Martin; Duquennoy, Simon

    2012-01-01

    Programming Internet of Things (IoT) applications is challenging because developers have to be knowledgeable in various technical domains, from low-power networking, over embedded operating systems, to distributed algorithms. Hence, it will be challenging to find enough experts to provide software for the vast number of expected devices, which must also be scalable and particularly safe due to the connection to the physical world. To remedy this situation, we propose an architecture that pr...

  10. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    A technique of selenium purification from 232Th, 238U, 226,228Ra, 227Ac and 40K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  11. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    Rakhimov, A.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz); Warot, G. [CEA-CNRS, Modane (France). Laboratoire Souterrain de Modane (LSM); Karaivanov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Institute for Nuclear Research and Nuclear Energy (INRNE), Sofia (Bulgaria); Kochetov, O.I.; Lebedev, N.A.; Filosofov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Mukhamedshina, N.M.; Sadikov, I.I. [Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz)

    2013-07-01

    A technique of selenium purification from {sup 232}Th, {sup 238}U, {sup 226,228}Ra, {sup 227}Ac and {sup 40}K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  12. Influence of Phase Constitution on Mechanical Performance of 12Ce-3Y-ZrO2/2.5 wt pct Al2O3 Composites

    Shuigen HUANG; Lin LI; J.Vlugels; O.V.D.Biest

    2004-01-01

    The phase constitution of a composite consisting of 12 at. Pct CeO2-3 at. Pct Y2O3-ZrO2/2.5 wt pct Al2O3 (3Y12Ce2.5Al) was determined by thermodynamic calculation. It is a combination of 36.9 at. Pct cubic phase and 63.1 at. Pct tetragonal phase at 1450℃. Green compacts were fabricated by cold isostatic pressing with powder synthesized by coating technique, and pressureless sintered at 1450℃. The fracture toughness and Vickers hardness, evaluated by the micro-indentation method, are 2.02 Mpa·m1/2 and 11.395 Gpa, respectively. The addition of 3 at. Pct Y2O3 to 12 at. Pct CeO2-ZrO2 ceramic leads to drastically decrease in toughness compared to composites without yttria stabilizer. No monoclinic phase is detected on the surface of all the ground samples. The high content of cubic phase and lack of phase transformation can be attributed to the low toughness based on the thermodynamic prediction.

  13. Charged hadron multiplicity fluctuations in Au+Au and Cu+Cu collisions from sqrt(s_NN) = 22.5 to 200 GeV

    Adare, A; Afanasiev, S; Aidala, C; Ajitanand, N N; Akiba, Y; Al-Bataineh, H; Alexander, J; Al-Jamel, A; Aoki, K; Aphecetche, L; Armendariz, R; Aronson, S H; Asai, J; Atomssa, E T; Averbeck, R; Awes, T C; Azmoun, B; Babintsev, V; Baksay, G; Baksay, L; Baldisseri, Alberto; Barish, K N; Barnes, P D; Bassalleck, B; Bathe, S; Batsouli, S; Baublis, V; Bauer, F; Bazilevsky, A; Belikov, S; Bennett, R; Berdnikov, Y; Bickley, A A; Bjorndal, M T; Boissevain, J G; Borel, H; Boyle, K; Brooks, M L; Brown, D S; Bruner, N; Bucher, D; Büsching, H; Bumazhnov, V; Bunce, G; Burward-Hoy, J M; Butsyk, S; Camard, X; Campbell, S; Chai, J S; Chand, P; Chang, B S; Chang, W C; Charvet, J L; Chernichenko, S; Chiba, J; Chi, C Y; Chiu, M; Choi, I J; Choudhury, R K; Chujo, T; Chung, P; Churyn, A; Cianciolo, V; Cleven, C R; Cobigo, Y; Cole, B A; Comets, M P; Constantin, P; Csanad, M; Csrgo, T; Cussonneau, J P; Dahms, T; Das, K; Dávid, G; Dek, F; Deaton, M B; Dehmelt, K; Delagrange, oa H; Denisov, A; d'Enterria, D; Deshpande, A; Desmond, E J; Devismes, A; Dietzsch, O; Dion, A; Donadelli, M; Drachenberg, J L; Drapier, O; Drees, A; Dubey, A K; Durum, A; Dutta, D; Dzhordzhadze, V; Efremenko, Yu V; Egdemir, J; Ellinghaus, F; Emam, W S; Enokizono, A; Enyo, H; Espagnon, B; Esumi, S; Eyser, K O; Fields, D E; Finck, C; Finger, M; Finger, M; Fleuret, F; Fokin, S L; Forestier, B; Fox, B D; Fraenkel, Zeev; Frantz, J E; Franz, A; Frawley, A D; Fujiwara, K; Fukao, Y; Fung, S Y; Fusayasu, T; Gadrat, S; Garishvili, I; Gastineau, F; Germain, M; Glenn, A; Gong, H; Gonin, M; Gosset, J; Goto, Y; Granier de Cassagnac, R; Grau, N; Greene, S V; Grosse-Perdekamp, M; Gunji, T; Gustafsson, H; Hachiya, T; Hadj Henni, A; Haegemann, C; Haggerty, J S; Hagiwara, M N; Hamagaki, AH; Han, R; Hansen, A G; Harada, H; Hartouni, E P; Haruna, K; Harvey, M; Haslum, E; Hasuko, K; Hayano, R; Heffner, M; Hemmick, T K; Hester, T; Heuser, J M; He, X; Hidas, P; Hiejima, H; Hill, J C; Hobbs, R; Hohlmann, M; Holmes, M; Holzmann, W; Homma, K; Hong, B; Hoover, A; Horaguchi, T; Hornback, D; Hur, M G; Ichihara, T; Ikonnikov, V V; Imai, K; Inaba, M; Inoue, Y; Inuzuka, M; Isenhower, D; Isenhower, L; Ishihara, M; Isobe, T; Issah, M; Isupov, A; Jacak, B V; Jia, J; Jin, J; Jinnouchi, O; Johnson, B M; Johnson, S C; Joo, K S; Jouan, D; Kajihara, F; Kametani, S; Kamihara, N; Kamin, J; Kaneta, M; Kang, J H; Kanou, H; Katou, K; Kawabata, T; Kawagishi, T; Kawall, D; Kazantsev, A V; Kelly, S; Khachaturov, B; Khanzadeev, A; Kikuchi, J; Kim, D H; Kim, D J; Kim, E; Kim, G B; Kim, H J; Kim, Y S; Kinney, E; Kiss, A; Kistenev, E; Kiyomichi, A; Klay, J; Klein-Bösing, C; Kobayashi, H; Kochenda, L; Kochetkov, V; Kohara, R; Komkov, B; Konno, M; Kotchetkov, D; Kozlov, A; Krl, A; Kravitz, a A; Kroon, P J; Kubart, J; Kuberg, C H; Kunde, G J; Kurihara, N; Kurita, K; Kweon, M J; Kwon, Y; Kyle, G S; Lacey, R; Lai, Y S; Lajoie, J G; Lebedev, A; Le Bornec, Y; Leckey, S; Lee, D M; Lee, M K; Lee, T; Leitch, M J; Leite, M A L; Lenzi, B; Lim, H; Lika, T; Litvinenko, s A; Liu, M X; Li, X; Li, X H; Love, B; Lynch, D; Maguire, C F; Makdisi, Y I; Malakhov, A; Malik, M D; Man'ko, V I; Mao, Y; Martínez, G; Maek, L; Masui, H; Matathias, F; Matsumoto, T; McCain, M C; McCumber, M; McGaughey, P L; Miake, Y; Mike, P; Miki, K; Miller, sT E; Milov, A; Mioduszewski, S; Mishra, G C; Mishra, M; Mitchell, J T; Mitrovski, M; Mohanty, A K; Morreale, A; Morrison, D P; Moss, J M; Moukhanova, T V; Mukhopadhyay, D; Muniruzzaman, M; Murata, J; Nagamiya, S; Nagata, Y; Nagle, J L; Naglis, M; Nakagawa, I; Nakamiya, Y; Nakamura, T; Nakano, K; Newby, J; Nguyen, M; Norman, B E; Nyanin, A S; Nystrand, J; O'Brien, E; Oda, S X; Ogilvie, C A; Ohnishi, H; Ojha, I D; Okada, H; Okada, K; Oka, M; Omiwade, O O; Oskarsson, A; Otterlund, I; Ouchida, M; Oyama, K; Ozawa, K; Pak, R; Pal, D; Palounek, A P T; Pantuev, V; Papavassiliou, V; Park, J; Park, W J; Pate, S F; Pei, H; Penev, V; Peng, J C; Pereira, H; Peresedov, V; Peressounko, D Yu; Pierson, A; Pinkenburg, C; Pisani, R P; Purschke, M L; Purwar, A K; Qualls, J M; Qu, H; Rak, J; Rakotozafindrabe, A; Ravinovich, I; Read, K F; Rembeczki, S; Reuter, M; Reygers, K; Riabov, V; Riabov, Y; Roche, G; Romana, A; Rosati, M; Rosendahl, S S E; Rosnet, P; Rukoyatkin, P; Rykov, V L; Ryu, S S; Sahlmueller, B; Saitô, N; Sakaguchi, T; Sakai, S; Sakata, H; Samsonov, V; Sanfratello, L; Santo, R; Sato, H D; Sato, S; Sawada, S; Schutz, Y; Seele, J; Seidl, R; Semenov, V; Seto, R; Sharma, D; Shea, T K; Shein, I; Shevel, A; Shibata, T A; Shigaki, K; Shimomura, M; Shohjoh, T; Shoji, K; Sickles, A; Silva, C L; Silvermyr, D; Silvestre, C; Sim, K S; Singh, C P; Singh, V; Skutnik, S; Sluneka, M; Smith, W C; Soldatov, A; Soltz, R A; Sondheim, W E; Sorensen, cS P; Sourikova, I V; Staley, F; Stankus, P W; Stenlund, E; Stepanov, M; Ster, A; Stoll, S P; Sugitate, T; Suire, C; Sullivan, J P; Sziklai, J; Tabaru, T; Takagi, S; Takagui, E M; Taketani, A; Tanaka, K H; Tanaka, Y; Tanida, K; Tannenbaum, M J; Taranenko, A; Tarjn, P; Thomas, a T L; Togawa, M; Toia, A; Tojo, J; Tomaek, L; Torii, H; Towell, R S; Tram, V-N; Tserruya, Itzhak; Tsuchimoto, Y; Tuli, S K; Tydesj, H; Tyurin, N; Uam, T J; Vale, C; Valle, H; van Hecke, o H W; Velkovska, J; Velkovsky, M; Vertesi, R; Veszprmi, V; Vinogradov, A A; Virius, M; Volkov, e M A; Vrba, V; Vznuzdaev, E; Wagner, M; Walker, D; Wang, X R; Watanabe, Y; Wessels, J; White, S N; Willis, N; Winter, D; Wohn, F K; Woody, C L; Wysocki, M; Xie, W; Yamaguchi, Y L; Yanovich, A; Yasin, Z; Ying, J; Yokkaichi, S; Young, G R; Younus, I; Yushmanov, I E; Zajc, W A; Zaudtke, O; Zhang, C; Zhou, S; Zimányi, J; Zolin, L; Zong, X

    2008-01-01

    A comprehensive survey of event-by-event fluctuations of charged hadron multiplicity in relativistic heavy ions is presented. The survey covers Au+Au collisions at sqrt(s_NN) = 62.4 and 200 GeV, and Cu+Cu collisions sqrt(s_NN) = 22.5, 62.4, and 200 GeV. Fluctuations are measured as a function of collision centrality, transverse momentum range, and charge sign. After correcting for non-dynamical fluctuations due to fluctuations in the collision geometry within a centrality bin, the remaining dynamical fluctuations expressed as the variance normalized by the mean tend to decrease with increasing centrality. The dynamical fluctuations are consistent with or below the expectation from a superposition of participant nucleon-nucleon collisions based upon p+p data, indicating that this dataset does not exhibit evidence of critical behavior in terms of the compressibility of the system. An analysis of Negative Binomial Distribution fits to the multiplicity distributions demonstrates that the heavy ion data exhibit we...

  14. Radio galaxies in ZFOURGE/NMBS: no difference in the properties of massive galaxies with and without radio-AGN out to z = 2.25

    Rees, G A; Norris, R P; Cowley, M J; Papovich, C; Glazebrook, K; Quadri, R F; Straatman, C M S; Allen, R; Kacprzak, G G; Labbe, I; Nanayakkara, T; Tomczak, A R; Tran, K -V

    2015-01-01

    In order to reproduce the high-mass end of the galaxy mass-distribution, some process must be responsible for the suppression of star-formation in the most massive of galaxies. Commonly Active Galactic Nuclei (AGN) are invoked to fulfil this role, but the exact means by which they do so is still the topic of much debate, with studies finding evidence for both the suppression and enhancement of star-formation in AGN hosts. Using the ZFOURGE and NMBS galaxy surveys, we investigate the host galaxy properties of a mass-limited (M$_{\\odot}$ $\\ge$ 10$^{10.5}$ M$_{\\odot}$), high-luminosity (L$_{1.4}$ $>$ 10$^{24}$ W Hz$^{-1}$) sample of radio-loud Active Galactic Nuclei to a redshift of z = 2.25. In contrast to low redshift studies, which associate radio-AGN activity with quiescent hosts, we find that the majority of z $>$ 1.5 radio-AGN are hosted by star-forming galaxies. Indeed, the stellar populations of radio-AGN are found to evolve with redshift in a manner that is consistent with the non-AGN mass-similar galax...

  15. Finite element analysis of type IV cracking in 2.25Cr-1Mo steel weldment based on micro-mechanistic approach

    Goyal, Sunil; Laha, K.; Chandravathi, K. S.; Parameswaran, P.; Mathew, M. D.

    2011-08-01

    Creep studies were carried out on 2.25Cr-1Mo steel base metal and its fusion-welded weldments at 823 K over the stress range 100-240 MPa. The weldment possessed lower creep rupture strength than the base metal due to type IV failure at the outer edge of the heat-affected zone (HAZ). Premature failure of the weldment was associated with pronounced creep cavitation accompanied with localized creep deformation in the soft intercritical region of the HAZ that was sandwiched between relatively higher creep deformation-resistant microstructural regions. The cavitation was associated with coarse intergranular precipitates in the intercritical region of the HAZ. The type IV cracking in the intercritical region of the HAZ was found to initiate deep inside the weldment and propagate towards the specimen surface. Finite element analysis of stress and strain distributions across the weldment was carried out considering the micro-mechanical strength inhomogeneity across it to explain the observed features of type IV cracking. The estimated higher von-Mises and principal stresses deep inside the intercritical region of the HAZ of the weldment led to the localized creep deformation and preferential cavity nucleation and growth, resulting in type IV failure of the weldment. The role of intergranular precipitate particles in the intercritical region of the HAZ in facilitating creep cavity nucleation by the exhaustion of creep ductility of the material close to the precipitate was corroborated from finite element analysis of stress and strain distribution around the precipitates.

  16. Keck and VLT Observations of Super-damped Lyman-alpha Absorbers at z=2=2.5: Constraints on Chemical Compositions and Physical Conditions

    Kulkarni, Varsha P; Morrison, Sean; Peroux, Celine; Quiret, Samuel; York, Donald G

    2015-01-01

    We report Keck/ESI and VLT/UVES observations of three super-damped Lyman-alpha quasar absorbers with H I column densities log N(HI) >= 21.7 at redshifts z=2-2.5. All three absorbers show similar metallicities (-1.3 to -1.5 dex), and dust depletion of Fe, Ni, and Mn. Two of the absorbers show supersolar [S/Zn] and [Si/Zn]. We combine our results with those for other DLAs to examine trends between N(HI), metallicity, dust depletion. A larger fraction of the super-DLAs lie close to or above the line [X/H]=20.59-log N(HI) in the metallicity vs. N(HI) plot, compared to the less gas-rich DLAs, suggesting that super-DLAs are more likely to be rich in molecules. Unfortunately, our data for Q0230-0334 and Q0743+1421 do not cover H2 absorption lines. For Q1418+0718, some H2 lines are covered, but not detected. CO is not detected in any of our absorbers. For DLAs with log N(HI) 21.7 may have somewhat narrower velocity dispersions delta v_90 than the less gas-rich DLAs, and may arise in cooler and/or less turbulent gas.

  17. Effect of service exposure on the mechanical properties of 2.25Cr-1Mo pressure vessel steel in a hot-wall hydrofining reactor

    Life assessment for hydrocarbon processing plant components is important for both service life extension and also to minimize the potential for premature catastrophic failure. In this paper, the degradation of 2.25Cr-1Mo pressure vessel steel in a hot-wall hydrofining reactor is investigated. A test block containing a weld is exposed to the chemical service environment present within a reactor. After removal from the reactor, chemical composition, tensile behavior, impact performance are quantified and the microstructure characterized using scanning electron microscopy (SEM). Results from the tensile tests indicate that the irradiated weld and base material had similar stress-strain response. Results from the Charpy V-Notch (CVN) impact tests demonstrated that the toughness of both the base material and weld were degraded with the degradation and embrittlement of the weld zone being significantly higher than the base material. Through careful processing of additional samples extracted from the test block, using (a) de-hydrogen treatment to remove the hydrogen, (b) hydrogen charging to enrich the hydrogen content to saturated condition and (c) de-brittleness treatment, additional fracture experiments confirmed that the toughness degradation was mainly caused by high temperature tempering and not by the effects of hydrogen embrittlement due to long-term exposure

  18. What is controlling the fragmentation process in the Infrared Dark Cloud G14.225-0.506? Differet level of fragmentation in twin hubs

    Busquet, G; Palau, A; Liu, H B; Zhang, Q; Girart, J M; de Gregorio-Monsalvo, I; Pillai, T; Anglada, G; Ho, P T P

    2016-01-01

    We present observations of the 1.3 mm continuum emission toward hub-N and hub-S of the infrared dark cloud G14.225-0.506 carried out with the Submillimeter Array, together with observations of the dust emission at 870 and 350 microns obtained with APEX and CSO telescopes. The large scale dust emission of both hubs consists of a single peaked clump elongated in the direction of the associated filament. At small scales, the SMA images reveal that both hubs fragment into several dust condensations. The fragmentation level was assessed under the same conditions and we found that hub-N presents 4 fragments while hub-S is more fragmented, with 13 fragments identified. We studied the density structure by means of a simultaneous fit of the radial intensity profile at 870 and 350 microns and the spectral energy distribution adopting a Plummer-like function to describe the density structure. The parameters inferred from the model are remarkably similar in both hubs, suggesting that density structure could not be respon...

  19. 窒息新生儿225例血糖分析%Analysis of the blood sugar in asphyxial neonates

    吴起武

    2009-01-01

    目的 探讨窒息新生儿血糖的变化.方法 对225例窒息新生儿和43例对照组新生儿进行血糖检测和分析.结果 窒息组和对照组血糖水平比较差异无统计学意义[(3.85±2.01)与(4.37±1.01),P>0.05],重度窒息组血糖水平和高血糖发生率均显著高于轻度窒息组(均P 0.05]. The quantity of blood sugar and the incidence rate of hyperglycosemia in seriously asphyxial group were more greater than slightly asphyxial group(P <0.01). The quantity of blood sugar in slighdy asphyxial group was less than the control group (P < 0.05). The quantiy of blood sugar in asphyxial premature infants was significantly less than asphyxial full-term infants(P < 0.05). Conclusions The blood sugar level in asphyxial neonates is relative to the degree of asphyxia and gestational age. The blood sugar in highly asphyxial neonates rise whereas in slightly as-phyxial neonates and asphyxial premature infants reduce.

  20. Controlled crystallization of β-In2S3 in 65GeS2.25In2S3.10CsCl chalcohalide glass

    65GeS2.25In2S3.10CsCl chalcohalide glass-ceramics containing β-In2S3 crystallites in the glassy matrix were prepared by traditional melt-quenching and subsequent heat-treatment at a fairly low temperature (Tg +10 circle C) for different durations. The transmission spectra show that the cut-off edge of short wavelength is red-shifted with the prolongation of annealing time, but remains an excellent transmittance in the mid-IR region. Meanwhile, its crystallization behavior was investigated systematically. The results show that the precipitation of β-In2S3 crystal phase is responsible for the first crystallization peak, and the second crystal phase is GeS2, which precipitated in the interior after a heat treatment at a high temperature (Tg +70 circle C). Furthermore, the crystallization mechanism was investigated using the non-isothermal method. The crystallization rate constant K value of 6.08 x 10 -4 s -1 at 346 circle C for the β-In2S3 phase is about three times larger than that of the GeS2 phase, indicating a much easier crystallization mechanism of β-In2S3 phase. Therefore, it is easy to control the precipitation of sole β-In2S3 crystallite, and to avoid interference of the second crystal phase GeS2. (orig.)

  1. Equilibrium viscosity of the Zr41.2Ti13.8Cu12.5Ni10Be22.5 bulk metallic glass-forming liquid and viscous flow during relaxation, phase separation, and primary crystallization

    The flow behavior of the supercooled Zr41.2Ti13.8Cu12.5Ni10Be22.5 bulk metallic glass-forming liquid is studied in isothermal three-point beam-bending experiments. The experiments lead to the determination of the equilibrium viscosity as a function of temperature. Comparison with other glass-forming liquids shows that the Zr41.2Ti13.8Cu12.5Ni10Be22.5, alloy is a strong liquid, similar to sodium silicate liquids. Flow measurements during phase separation and subsequent formation of crystals embedded in a non-crystalline matrix reveal a dramatic slowdown of the kinetics of the matrix that is expressed in an increase of the viscosity by several orders of magnitude

  2. Studying the properties and response of a large volume (946 cm3) LaBr3:Ce detector with γ-rays up to 22.5 MeV

    This paper presents the results of our measurements and detailed simulations using GEANT4 to investigate the performance of a large volume (946 cm3) cylindrical (3.5in.diameter×6in.length) LaBr3:Ce detector. The properties of the detector have been studied using γ-rays from radioactive sources and in-beam reaction, from few hundred keV to 22.5 MeV. The salient features, which have been studied in-depth, are the uniformity and internal activity of the crystal, the energy and timing resolutions, linearity of the response up to 22.5 MeV, and efficiencies. A highly linear response has been observed by extracting the energy signal from a lower dynode and operating the PMT at a low voltage. The detector is to be primarily used for measuring high energy γ-rays spectra from Giant Dipole Resonance (GDR) decay studies

  3. Zr41Be22.5Ti14Cu12.5Ni10非晶合金摩擦焊工艺及温度场数值模拟%Friction Welding of Zr41Be22.5Ti14Cu12.5Ni10 Bulk Metallic Glass and Numerical Simulation of Temperature Field

    张帅谋; 张雪峰; 陈彪

    2015-01-01

    采用摩擦焊工艺对Zr41Be22.5Ti14Cu12.5Ni10非晶合金进行焊接,通过优化焊接参数,得到焊接接头.采用XRD、TEM、维氏显微硬度计对试样接头进行了测试.结果表明,优化后的焊接参数可以成功得到焊接接头,试样仍保持非晶特性,且接头力学性能有所增加.采用ANSYS软件对摩擦焊进行温度场数值模拟,可以验证摩擦焊的工艺参数选择合理.

  4. 三个新HLA等位基因A*24:224,A*24:225和A*24:257的测序鉴定%Identification of 3 novel HLA-A alleles A * 24: 224, A * 24 : 225 and A * 24: 257 by sequence-based typing

    朱传福; 张红卫; 张毅; 聂向民

    2015-01-01

    目的 鉴定3个在中国汉族人群中发现的人类白细胞抗原(human leukocyte antigen,HLA)A位点新等位基因A* 24:224、A* 24:225和A* 24:257.方法 应用双链直接测序分型技术进行中华骨髓库志愿者常规HLA分型,对其中HLA-A位点无完全匹配结果者,采用等位基因特异性扩增测序分型方法进行新等位基因序列鉴定.结果 3例先证者在HLA-A位点分别有一个未知的新碱基序列,3个新序列均与HLA-A* 24:02:01:01最为相近,但在第2外显子分别出现了1或2个的碱基取代,并导致相应的密码子及其编码的氨基酸的改变.结论 3个新碱基序列均确认为HLA-A新等位基因,分别于2012年11月和2013年11月被世界卫生组织HLA因子命名委员会正式命名为HLA-A* 24:224、HLA-A*24:225和HLA-A* 24:257.%Objective To verify 3 novel HLA-A alleles A * 24:224,A * 24:225 and A * 24:257 identified in Chinese Han individuals.Methods No full matched results were obtained at HLA-A locus in HLA typing for China Marrow Donor Program (CMDP) using bi-allelic Sequence-Based Typing (SBT).The novel HLA alleles were identified with allele-specific amplification SBT.Results All of the three probands had a novel nucleotide sequence at HLA-A locus.All of the 3 new sequences are most close to HLA-A* 24:02:01:01 except for 1 or 2 nucleotide substitution in exon 2,which resulted in different changes in corresponding codons and encoded amino acids.Conclusion Three novel HLA-A alleles were confirmed and officially named as HLA-A * 24:224,HLA-A * 24:225 and HLA-A * 24:257 under the GenBank accession numbers JQ899198,JQ924283 and HG003642 by the WHO Nomenclature Committee for Factors of the HLA System in November 2012 and November 2013,respectively.

  5. Documentation associated with the shipping of Hot-Cell Waste from WESF 225-B to the 200W (218-W-3AE) burial grounds under shipment number RSR-37338

    The purpose of this report is to compile the records generated during the Packaging and Shipping of WESF Hot-Cell Waste from the 225-B Facility to 200W (218-W-3AE) burial grounds. A total of six 55-gallon drums were packaged and shipped using the Chem-Nuc Cask in accordance with WHC-SD-TP-SARP-025, Rev.0 ''Safety Analysis Report for Packaging (Onsite) for Type B Material in the CNS-14-215H Cask''

  6. miR-22-5p revealed as a potential biomarker involved in the acute phase of myocardial infarction via profiling of circulating microRNAs.

    Maciejak, Agata; Kiliszek, Marek; Opolski, Grzegorz; Segiet, Agnieszka; Matlak, Krzysztof; Dobrzycki, Slawomir; Tulacz, Dorota; Sygitowicz, Grazyna; Burzynska, Beata; Gora, Monika

    2016-09-01

    Acute myocardial infarction (AMI) is a life-threatening episode of coronary artery disease. Recently, circulating myocardial-derived microRNAs (miRNAs) have been reported as potential biomarkers of infarction. The present study aimed to identify differentially expressed miRNAs in patients with ST-segment elevation myocardial infarction that could be potentially dysregulated in response to early myocardial damage. miRNA expression profile analysis was performed using the Serum/Plasma Focus miRNA Polymerase Chain Reaction (PCR) panel of Exiqon A/S (Vedbaek, Denmark) on plasma samples of patients on the first day of AMI (admission) and on samples from the identical patients collected six months following AMI. Selected miRNAs were validated by reverse transcription‑quantitative PCR (RT‑qPCR) using independent patients with AMI and a control group of patients with a stable coronary artery disease. Thirty‑two species of plasma miRNA were differentially expressed (P<0.05) on admission compared with six months following AMI. Subsequent validation in an independent patient group confirmed that miR‑133b and miR‑22‑5p were significantly up‑regulated in the serum of patients with AMI. The receiver operating characteristic (ROC) curve analysis demonstrated a diagnostic utility for miR-22-5p, which has not previously been reported to be associated with AMI. Among the selected miRNAs, miR‑22‑5p represents a novel promising biomarker for the diagnosis of AMI. PMID:27484208

  7. Studies on electrochemical characterization and performance prediction of cellulose acetate and Zeocarb-225 composite membranes in aqueous NaCl solutions.

    Tiwari, A K; Ahmad, Suhail

    2006-06-01

    We have mixed cellulose acetate and Zeocarb-225 in different ratios, leading to the preparations of Membrane-1 and Membrane-2. Membrane potential, water content, and conductance measurements have been carried out to estimate and analyze the data in terms of equilibria and important electrochemical parameters. The Donnan equilibrium has been incorporated to estimate the activity coefficient of counterions, y(p)M, and solute, y(+/-)M in the membrane phase along with the parameter, so called varphi expressing non-ideality. Dependence of the extent of hydrophilicity of both membranes on mean electrolyte concentrations has been examined. Selectivity in membranes is discussed in terms of dissociation equilibria, K(d)s and K(d)f. It has been found that membrane surface charge density sigma(s) increases with increasing of external NaCl concentration. Dependence of water transport number and cationic transport number on electrolyte concentration shows a similar trend of variation. At higher mean concentration of electrolyte, water transport number in Membrane-2 has a negative value. Membrane-2 has a higher value of water transport number than Membrane-1. The entropy production due to solute and water transport has been quantified for both the membranes in the light of nonequilibrium thermodynamics. The various type of interactions such as solute-membrane, solute-water, and water-membrane are analyzed in terms of friction coefficients (f(ij)) of Spiegler's frictional pore model. In our case, an f(wm) diffusion-control criteria, i.e., (D(+/-) . C. d/D(+/-)M C(M) . delta) > 2. A slightly higher value of solute rejection is found in Membrane-2. PMID:16499917

  8. Existence of Fe{sup 4+} ions in Co{sub 2.25}Fe{sub 0.75}O{sub 4} spinel ferrite confirmed from SXRD and XANES spectroscopy

    Panda, Manas Ranjan, E-mail: manasranjan056@gmail.com; Bhowmik, R. N. [Department of Physics, Pondicherry University, R.Venkataraman Nagar, Kalapet, Pondicherry-605014 (India); Sinha, A. K. [Indus Synchrotrons Utilization Division, Raja Ramanna Centre for Advanced Technology, Indore-452013 (India)

    2015-06-24

    The Co{sub 2.25}Fe{sub 0.75}O{sub 4} ferrite composition has been prepared by chemical co-precipitation route. The as-prepared sample after annealing at 900°C in air formed single phase cubic spinel structure. Synchrotron X-ray diffraction and X-ray absorption near edge structure (XANES) measurements were used to study charge states of the cations in octahedral and tetrahedral sites of the cubic spinel structure. Raman spectra indicated normal cubic spinel structure. XANES data suggested the existence of Fe{sup 4+} ions in the spinel structure.

  9. Non-isothermal crystallization kinetics of Zr{sub 41.2}Ti{sub 13.8}Cu{sub 12.5}Ni{sub 10}Be{sub 22.5} amorphous alloy

    Cheng, Sirui [State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001 (China); Wang, Chunju [State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001 (China); Key Laboratory of Micro-Systems and Micro-Structures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin 150080 (China); Ma, Mingzhen [State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004 (China); Shan, Debin, E-mail: shandb@hit.edu.cn [State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001 (China); Key Laboratory of Micro-Systems and Micro-Structures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin 150080 (China); Guo, Bin [State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001 (China)

    2014-07-01

    Highlights: • Some kinetics parameters of Zr{sub 41.2}Ti{sub 13.8}Cu{sub 12.5}Ni{sub 10}Be{sub 22.5} amorphous alloy were calculated. • The first and third exothermic peaks at the heating rates of 5 K/min and 10 K/min split into two peaks. • The local Avrami exponents at various heating rates showed different trends under different heating rates. • The growth dimensionality reduced from 2 to 1 as heating rates increase. • The heating rate had significant influence on the growth mechanism during annealing. - Abstract: The thermodynamics and kinetics of Zr{sub 41.2}Ti{sub 13.8}Cu{sub 12.5}Ni{sub 10}Be{sub 22.5} amorphous alloy under non-isothermal condition were evaluated using differential scanning calorimetry (DSC). The first and third exothermic events at the heating rates of 5 K/min and 10 K/min split into two peaks. The local Avrami exponents at various heating rates calculated by the Kolmogorov–Johnson–Mehl–Avrami equations showed different trends. The grain growth was controlled by atom diffusion at all heating rates. But their growth dimensionality reduced from 2 to 1 as heating rates increase at the beginning of crystallization process. The result exhibited that the heating rate had a great influence on growth mechanism, the crystallization peaks of Zr{sub 41.2}Ti{sub 13.8}Cu{sub 12.5}Ni{sub 10}Be{sub 22.5} amorphous alloy separated into two single-step processes for the change of growth dimensionality. Two fragility indexes evaluated by Angell and DA equations were 44 and 42.5, respectively, implying that the as-cast Zr{sub 41.2}Ti{sub 13.8}Cu{sub 12.5}Ni{sub 10}Be{sub 22.5} amorphous alloy should be considered as “intermediate glasses”.

  10. Safety and Immunogenicity of Early Measles Vaccination in Children Born to HIV-Infected Mothers in the United States: Results of Pediatric AIDS Clinical Trials Group (PACTG) Protocol 225

    Chandwani, Sulachni; Beeler, Judy; Li, Hong; Audet, Susette; Smith, Betsy; Moye, John; Nalin, David; Krasinski, Keith

    2011-01-01

    Background. PACTG (Pediatric AIDS Clinical Trials Group) 225, a multicenter, randomized, open-label trial in the United States evaluated reactogenicity and immunogenicity of 2 vaccination regimens: monovalent measles vaccine (Attenuvax) at 6 months of age and measles, mumps, and rubella, live attenuated (MMRII) vaccine at 12 months of age (2D), or only MMRII at 12 months of age (1D) in human immunodeficiency virus–infected (HIV-infected) (POS) and uninfected (NEG) children in the pre–highly a...

  11. Growth of ∼5 cm2V−1s−1 mobility, p-type Copper(I oxide (Cu2O films by fast atmospheric atomic layer deposition (AALD at 225°C and below

    D. Muñoz-Rojas

    2012-12-01

    Full Text Available Phase pure, dense Cu2O thin films were grown on glass and polymer substrates at 225°C by rapid atmospheric atomic layer deposition (AALD. Carrier mobilities of 5 cm2V−1s−1 and carrier concentrations of ∼1016 cm−3 were achieved in films of thickness 50 - 120 nm, over a >10 cm2 area. Growth rates were ∼1 nm·min−1 which is two orders of magnitude faster than conventional ALD.. The high mobilities achieved using the atmospheric, low temperature method represent a significant advance for flextronics and flexible solar cells which require growth on plastic substrates.

  12. Growth of ˜5 cm2V-1s-1 mobility, p-type Copper(I) oxide (Cu2O) films by fast atmospheric atomic layer deposition (AALD) at 225°C and below

    Muñoz-Rojas, D.; Jordan, M.; Yeoh, C.; Marin, A. T.; Kursumovic, A.; Dunlop, L. A.; Iza, D. C.; Chen, A.; Wang, H.; MacManus Driscoll, J. L.

    2012-12-01

    Phase pure, dense Cu2O thin films were grown on glass and polymer substrates at 225°C by rapid atmospheric atomic layer deposition (AALD). Carrier mobilities of 5 cm2V-1s-1 and carrier concentrations of ˜1016 cm-3 were achieved in films of thickness 50 - 120 nm, over a >10 cm2 area. Growth rates were ˜1 nm.min-1 which is two orders of magnitude faster than conventional ALD.. The high mobilities achieved using the atmospheric, low temperature method represent a significant advance for flextronics and flexible solar cells which require growth on plastic substrates.

  13. Growth of ∼5 cm2V−1s−1 mobility, p-type Copper(I) oxide (Cu2O) films by fast atmospheric atomic layer deposition (AALD) at 225°C and below

    D. Muñoz-Rojas; Jordan, M.; Yeoh, C; A. T. Marin; A. Kursumovic; Dunlop, L. A.; Iza, D. C.; Chen, A; Wang, H.; J. L. MacManus Driscoll

    2012-01-01

    Phase pure, dense Cu2O thin films were grown on glass and polymer substrates at 225°C by rapid atmospheric atomic layer deposition (AALD). Carrier mobilities of 5 cm2V−1s−1 and carrier concentrations of ∼1016 cm−3 were achieved in films of thickness 50 - 120 nm, over a >10 cm2 area. Growth rates were ∼1 nm·min−1 which is two orders of magnitude faster than conventional ALD.. The high mobilities achieved using the atmospheric, low temperature method represent a significant advance for flextron...

  14. Estudio del comportamiento del acero 2.25Cr-1Mo frente a los fenómenos de oxidación cíclica e isoterma

    Proy, Manuel; Victoria Utrilla, M; Otero, Enrique

    2014-01-01

    Cyclic and isothermal oxidation of chromium-molybdenum steel 2.25Cr-1Mo were analyzed at 550 °C and 650 °C during 360 hours in air atmospheres. The cycles were performed with two stages; one of heating in furnace during 90 minutes and then the sample were cooled to 50 °C by air flow. Thermogravimetric analyses were performed to obtain high temperature corrosion kinetics. Several characterization techniques have been used to identify the corrosion mechanism, as X-Ray Diffraction (XRD), Optical...

  15. Processing of carbon-fiber-reinforced Zr41.2Ti13.8Cu12.5Ni10.0Be22.5 bulk metallic glass composites

    Kim, C. P.; Busch, R.; Masuhr, A.; Choi-Yim, H.; Johnson, W. L.

    2001-01-01

    Carbon-fiber-reinforced bulk metallic glass composites are produced by infiltrating liquid Zr41.2Ti13.8Cu12.5Ni10.0Be22.5 into carbon fiber bundles with diameter of the individual fiber of 5 mum. Reactive wetting occurs by the formation of a ZrC layer around the fibers. This results in a composite with a homogeneous fiber distribution. The volume fraction of the fibers is about 50% and the density of the composite amounts to 4.0 g/cm(^3).

  16. Examination of deformation mechanism maps in 2.25Cr-1Mo steel by creep tests at strain rates of 10-11 to 10-6 s-1

    The deformation mechanism map of 2.25Cr-1Mo steel was examined by creep data obtained over a wide range of creep rates down to 10-11 s-1. The stress dependence of minimum creep rates of the steel is similar to that of particle strengthened materials: low, high, and low stress exponent, respectively, in high (H), intermediate (I), and low (L) stress regions. The stress exponent and activation energy for creep rate suggest dislocation creep controlled by lattice diffusion as the deformation mechanism in regions I and L, including service conditions of the steel. Transition to diffusion creep occurs at a lower creep rate than what is expected in the deformation mechanism maps. Region H appears above athermal yield stress. During loading in this region, athermal plastic deformation takes place by dislocation glide mechanism, and then dislocation creep starts. The dislocation creep in region H is different from the one in regions I and L due to the plastic deformation during loading. A modified creep mechanism map of 2.25Cr-1Mo steel is proposed on the basis of the experimental results. (orig.)

  17. Embracing a vision of the New Jerusalem (Rv 21:1−22:5 to impact on life and society

    Martin H. Pohlmann

    2015-03-01

    Full Text Available Apocalyptic biblical literature has played a significant role in motivating and mobilising Christians. As part of this genre, the Apocalypse of John has played this mobilising role within the church throughout its history. Jerusalem is often incorporated into this genre to conjure up different emotions and images to impact many different people. For example, the Jew annually recites the words to fellow Jews at every Passover meal: ‘Next year in Jerusalem’. Most Christians know the hymn ‘The holy city’, originally penned by Frederic Weatherly in 1892. It lifts many a spirit as it conjures up the idea of a beautiful, perfect, heavenly city of God. However, there is more to this apocalyptic vision, which will be explored in this article. The city upholds the hope of decent godly living today. Whilst Jerusalem is a city with an extremely chequered history, it remains to be the launching pad of a dream that believers can embrace in order to impact society for the better. The vision in Revelation 21–22 is the launch of the ‘idea’ of God’s intention for society today, and the ‘implementation impetus’ is the primary role of the church. In the greater scheme of things, the world community is the target group for a better society for everyone.Aanneming van ’n visioen van die Nuwe Jerusalem (Op 21:1–22:5 ten einde ’n invloed op lewe en die samelewing uit te oefen. Apokaliptiese Bybelliteratuur het ’n beduidende rol in die motivering en aansporing van Christengemeenskappe gespeel. Die Openbaring van Johannes het hierdie motiveringsrol deurgaans in die geskiedenis van die kerkas deel van dié genre vertolk. Jerusalem is dikwels hierby ingesluit om ’n verskeidenheid van emosies en beelde op te roep ten einde ’n impak op ’n verskeidenheid mense te maak. Die Jood, byvoorbeeld, haal jaarliks die volgende woorde teenoor mede-Jode tydens die Paasmaaltyd aan: ‘Volgende jaar in Jerusalem’. Die meeste

  18. 福州市娱乐场所225名女性性服务者艾滋病相关知识及行为特征%AIDS knowledge Levels and Behavior Characteristics of 225 Female Sex Workers in Entertainment Places of Fuzhou City

    陈传刚; 林华; 张宏

    2011-01-01

    [Objective]To understand HIV/AIDS prevention knowledge levels, high-risk behaviors, and HIV infection status among female sex workers in entertainment places, and provide scientific evidence for relevant departments in developing AIDS prevention and control measures.[Methods]A questionnaire survey on AIDS prevention and treatment knowledge was carried out among the female sex workers in 20 entertainment places of Fuzhou City during Nov 2009 -Jan 2010, their blood samples were collected to test for HIV antibody and syphilis antibody.[Results]Of 225 sex workers, 54.7% answered 8 questions about basic knowledge of AIDS prevention correctly.The awareness rate of AIDS knowledge was 76.0%.The percentage of condom use consistently within 1 month was 81.8%.The proportion of condom use in the last sexual behavior was 98.7%.4.0% of the surveyed subjects had drug behaviors.2 ( 0.9% ) were detected HIV positive.[Conclusion]The awareness rate of sex workers in entertainment places is not high.It is urgent to popularize AIDS prevention knowledge among them to prevent HIV spreading from high risk groups to the general population.%目的 了解娱乐场所女性性服务者的艾滋病(AIDS)防治知识、行为和人类免疫缺陷病毒(HIV)感染情况,为有关部门制定艾滋病防治措施提供科学依据.方法 2009年11月-2010年1月期间对福州市20家娱乐场所内从事商业性交易的女性性服务者进行艾滋病防治知识问卷调查,并现场采集血液检测HIV抗体和梅毒抗体.结果 225名女性性服务者中,对调查问卷8道艾滋病防治基本知识题全部答对的占54.7%,艾滋病知识知晓率为76.0%,最近1个月和最近1次与客人发生性关系,每次都使用安全套的分别占81.8%和98.7%,4.0%的调查对象有吸毒行为,检出HIV感染者2例,阳性率为0.9%.结论 娱乐场所女性性服务者对艾滋病防治知识知晓率不高.亟需对她们普及艾滋病预防相关知识,阻止艾滋病由高危人群向一般人群扩散.

  19. 锦州市225名老年人骨质疏松相关症状及危险因素的调查分析%An Investigation of Osteoporosis and Related Risk Factors Among 225 Elderly People in Jinzhou

    侯璇; 吴巧凤; 金炜婷; 刘堃

    2014-01-01

    目的:调查锦州市社区患有骨质疏松的老年人群中出现骨质疏松相关症状及其危险因素情况,为社区老年人骨质疏松的预防提供依据。方法采用自行设计的问卷对锦州市225名60周岁及以上患有骨质疏松的社区老年人进行调查,并利用 SPSS 17.0软件进行数据的录入和分析。结果锦州市225名社区老年人中,髋部疼痛13人(5.8%);背疼25人(11.1%);腰疼70人(31.1%);腿疼63人(28.0%);关节疼痛39人(17.3%);脆性骨折20人(8.9%);驼背31人(13.8%);身长缩短93人(41.3%)。晒太阳30分钟及以上的有212人(94.2%);体育锻炼每周3次及以上的有201人(89.3%);静坐时间6 h 以上的有29人(12.9%);补钙(24.4%)和补充维生素 D (16.9%)者较少。各年龄段中饮酒者和味重饮食者以60岁~年龄段居多,补钙者以75岁~和≥80岁最多;饮浓茶、吸烟、饮酒、静坐时间6 h 以上男性多于女性。喝浓茶、吸烟、饮酒、味重饮食、每天晒太阳30 min 以下、体育锻炼每周3次以下、静坐时间长、有激素用药史为危险因素,喜食豆制品、每天晒太阳30 min 以上、体育锻炼每周3次及以上为保护因素。结论避免骨质疏松危险因素,及早采取预防措施对阻止骨质疏松引发相关疾病具有重要意义。%Objective To investigate risk factors and symptoms of osteoporosis among elderly people in communities in the city of Jinzhou, providing preventive measure. Methods A questionnaire survey was carried out among 225 elderly people with osteoporosis who were above 60 years old and lived in communities of Jinzhou City. Data were analyzed by SPSS 17. 0. Results There were 13 people (5. 8% ) with a hip pain, 25 (11. 1% ) with back pain, 70 (31. 1% ) with low back pain, 63 (28. 0% ) with leg pain, 39 (17. 3% ) with joint pain, 20 (8. 9% ) with brittle fracture, 31 (13. 8% ) with hunchback and 93 (41. 3% ) with length shortening. 212 (94. 2% ) people

  20. Measurement of Inclusive ep Cross Sections at High Q2 at sqrt(s) = 225 and 252 GeV and of the Longitudinal Proton Structure Function FL at HERA

    Andreev, V.; Baghdasaryan, S.; Begzsuren, K.; Belousov, A.; Belov, P.; Boudry, V.; Brandt, G.; Brinkmann, M.; Brisson, V.; Britzger, D.; Buniatyan, A.; Bylinkin, A.; Bystritskaya, L.; Campbell, A.J.; Cantun Avila, K.B.; Ceccopieri, F.; Cerny, K.; Chekelian, V.; Contreras, J.G.; Dainton, J.B.; Daum, K.; De Wolf, E.A.; Diaconu, C.; Dobre, M.; Dodonov, V.; Dossanov, A.; Dubak, A.; Eckerlin, G.; Egli, S.; Elsen, E.; Favart, L.; Fedotov, A.; Feltesse, J.; Ferencei, J.; Fleischer, M.; Fomenko, A.; Gabathuler, E.; Gayler, J.; Ghazaryan, S.; Glazov, A.; Goerlich, L.; Gogitidze, N.; Gouzevitch, M.; Grab, C.; Grebenyuk, A.; Greenshaw, T.; Grindhammer, G.; Habib, S.; Haidt, D.; Henderson, R.C.W.; Herbst, M.; Hildebrandt, M.; Hladky, J.; Hoffmann, D.; Horisberger, R.; Hreus, T.; Huber, F.; Jacquet, M.; Janssen, X.; Jung, A.W.; Jung, H.; Kapichine, M.; Kiesling, C.; Klein, M.; Kleinwort, C.; Kogler, R.; Kostka, P.; Kretzschmar, J.; Kruger, K.; Landon, M.P.J.; Lange, W.; Laycock, P.; Lebedev, A.; Levonian, S.; Lipka, K.; List, B.; List, J.; Lobodzinski, B.; Lubimov, V.; Malinovski, E.; Martyn, H.U.; Maxfield, S.J.; Mehta, A.; Meyer, A.B.; Meyer, H.; Meyer, J.; Mikocki, S.; Morozov, A.; Muller, K.; Naumann, Th.; Newman, P.R.; Niebuhr, C.; Nowak, G.; Nowak, K.; Olivier, B.; Olsson, J.E.; Ozerov, D.; Pahl, P.; Pascaud, C.; Patel, G.D.; Perez, E.; Petrukhin, A.; Picuric, I.; Pirumov, H.; Pitzl, D.; Placakyte, R.; Pokorny, B.; Polifka, R.; Radescu, V.; Raicevic, N.; Raspereza, A.; Ravdandorj, T.; Reimer, P.; Rizvi, E.; Robmann, P.; Roosen, R.; Rostovtsev, A.; Rotaru, M.; Rusakov, S.; Salek, D.; Sankey, D.P.C.; Sauter, M.; Sauvan, E.; Schmitt, S.; Schoeffel, L.; Schoning, A.; Schultz-Coulon, H.C.; Sefkow, F.; Shushkevich, S.; Soloviev, Y.; Sopicki, P.; South, D.; Spaskov, V.; Specka, A.; Steder, M.; Stella, B.; Straumann, U.; Sykora, T.; Thompson, P.D.; Traynor, D.; Truol, P.; Tsakov, I.; Tseepeldorj, B.; Turnau, J.; Valkarova, A.; Vallee, C.; Van Mechelen, P.; Vazdik, Y.; Wegener, D.; Wunsch, E.; Zacek, J.; Zhang, Z.; Zlebcik, R.; Zohrabyan, H.; Zomer, F.

    2014-01-01

    Inclusive ep double differential cross sections for neutral current deep inelastic scattering are measured with the H1 detector at HERA. The data were taken with a lepton beam energy of 27.6 GeV and two proton beam energies of Ep = 460 and 575 GeV corresponding to centre-of-mass energies of 225 and 252 GeV, respectively. The measurements cover the region of 6.5 *10^{-4}<=x<= 0.65 for 35<=Q^2<=800 GeV^2 up to y = 0.85. The measurements are used together with previously published H1 data at Ep = 920 GeV and lower Q2 data at Ep = 460, 575 and 920 GeV to extract the longitudinal proton structure function FL in the region 1.5<=Q^2 <=800 GeV^2.

  1. Ozone decline and its effect on night airglow intensity of Na 5893°A at Dumdum (22.5°N, 88.5° E) and Halley Bay (76°S, 27°W)

    P K Jana; S C Nandi

    2006-10-01

    The paper presents the effect of O3 depletion on night airglow emission of Na 5893 A line at Dumdum (22.5°N, 88.5°E), India and Halley Bay (76°S, 27°W), a British Antarctic service station. Calculations based on chemical kinetics show that the airglow intensity of Na 5893 A line will also be affected due to the depletion of O3 concentration. The nature of yearly variation and seasonal variation of the intensity of Na 5893 A line for the above two stations are shown and compared. It is shown that the rate of decrease of intensity of Na 5893 A line is comparatively more at Halley Bay due to the dramatic decrease of Antarctic O3 concentration. A possible explanation for this dramatic decrease of Antarctic O3 concentration is also mentioned.

  2. Measurement of inclusive ep cross sections at high Q2 at √(s) = 225 and 252 GeV and of the longitudinal proton structure function FL at HERA

    Inclusive ep double differential cross sections for neutral current deep inelastic scattering are measured with the H1 detector at HERA.The data were taken with a lepton beam energy of 27.6 GeV and two proton beam energies of Ep = 460 and 575 GeV corresponding to centre-of-mass energies of 225 and 252 GeV, respectively. The measurements cover the region of 6.5 x 10-4 ≤ x ≤ 0.65 for 35 ≤ Q2 ≤ 800 GeV2 up to y = 0.85. The measurements are used together with previously published H1 data at Ep = 920 GeV and lower Q2 data at Ep = 460, 575 and 920 GeV to extract the longitudinal proton structure function FL in the region 1.5 ≤ Q2 ≤ 800 GeV2. (orig.)

  3. 他们凭什么站在世界之巅——2005年度全球225家最大国际承包商简评

    付勇生

    2006-01-01

    近日,美国麦格劳一希尔公司(McGraw-Hill)旗下的杂志《工程新闻记录》(ENR)公布了2005年度的225家最大国际承包商排名榜。随着近几年国际工程承包市场的迅逋蔓曼展,国际承包商的整体实力有了较大提高,因而今年的入门门槛提高到2300万美元的国际市场营业额。

  4. 也们凭什么站在世界之巅?——2005年度全球225家最大国际承包商简评

    付勇生

    2006-01-01

    近日,美国麦格劳-希尔公司(McGraw-Hill)旗下的杂志《工程新闻记录》(ENR)公布了2005年度的225家最大国际承包排名榜。随着近几年国际工程系承包市场的迅速发展,国际承包商的整体实力有了较大的提高,因而今年的入门门槛提高到2300万美元的国际市场营业额。

  5. SUPPRESSION OF PRESSOR RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION BY ESMOLOL ADMINISTERED IN DOSES OF 1.5 mg/kg, 2.25 mg/kg: A COMPARATIVE CLINICAL STUDY

    Roopa

    2016-03-01

    Full Text Available BACKGROUND Laryngoscopy and endotracheal intubation results in physiological changes of various body systems like heart rate and blood pressure in cardiovascular system. For attenuating the hyperdynamic cardiovascular response to tracheal intubation, numerous trials with many drugs were undertaken. AIM Of our study is to find out the safety and efficacy of attenuation of pressor response during laryngoscopy and tracheal intubation using Esmolol, administered as single intravenous bolus prior to induction of anaesthesia in two different doses of 1.5 mg/kg and 2.25 mg/kg. Control group was considered in our previous study using the same drug with different dosage, i.e. a dose of 0.75 mg/kg was compared with a placebo. We would like to go ahead with further increase in the dosage per kg body weight to get an ideal suppression of the pressor responses. MATERIALS AND METHODS The study was conducted in 50 patients, who were randomly assigned into 2 groups of 25 each. Group A (25 received Inj. Esmolol 1.5 mg/kg and Group B (25 received Inj. Esmolol 2.25 mg/kg IV before induction. RESULTS Heart rate and blood pressures were well maintained within physiological range in Group A, whereas there was a decrease in blood pressure and heart rate in the Group B immediately after intubation and at the end of 4th min. CONCLUSION In this study, the Group B showed an inappropriate decrease in mean values of Heart Rate, Blood Pressure immediately after administration.

  6. Estudio del comportamiento del acero 2.25Cr-1Mo frente a los fenómenos de oxidación cíclica e isoterma

    Proy, Manuel

    2014-03-01

    Full Text Available Cyclic and isothermal oxidation of chromium-molybdenum steel 2.25Cr-1Mo were analyzed at 550 °C and 650 °C during 360 hours in air atmospheres. The cycles were performed with two stages; one of heating in furnace during 90 minutes and then the sample were cooled to 50 °C by air flow. Thermogravimetric analyses were performed to obtain high temperature corrosion kinetics. Several characterization techniques have been used to identify the corrosion mechanism, as X-Ray Diffraction (XRD, Optical Microscopy (OM and Scanning Electron Microscopy (SEM. Thermal cycling tests can changes the corrosion mechanism, due cracks propagation in oxide scale, that witch can favors the access of oxidant agent to the substrate.La resistencia del acero aleado con cromo y molibdeno 2.25Cr-1Mo frente a la oxidación isotérmica y cíclica, fue evaluada a 550 °C y 650 °C durante 360 horas en aire. Los ciclos consistieron en el mantenimiento durante 90 minutos dentro del horno a la temperatura de ensayo y un periodo de enfriamiento forzado hasta 50 °C mediante la aplicación de un flujo de aire. Se realizó un estudio termogravimétrico para calcular las cinéticas de oxidación. Para conocer el mecanismo de degradación, se emplearon diversas técnicas de caracterización microestructural, como Difracción de Rayos (DRX, Microscopía Óptica (MO y Electrónica de Barrido (MEB. El ciclado térmico cambia el mecanismo de degradación, debido a la propagación de grietas en la película de óxido formada, que favorece el acceso del agente agresivo al sustrato.

  7. 2.25 Cr-1 Mo和2.25 Cr-1 Mo-0.25 V钢加氢反应器材料和制造经验%Materials and Fabrication Experience of 2 .25 Cr-1 Mo and 2.25 Cr-1 Mo-0.25 V Steel Hydrogenation Reactor

    张颖; 尚尔晶; 谷文

    2014-01-01

    The specifications in ASME code and API standard to material and fabrication of2.25Cr-1Mo and 2.25Cr-1Mo-0.25V steel hydrogenation reactor were introduced.Related requirements about tem-per brittleness,mechanical property and reheat crack of 2.25Cr-1Mo and 2.25Cr-1Mo-0.25V steel in the technical documents of domestic and overseas licensors were summarized.%介绍了ASME规范和API标准对2.25Cr-1Mo钢和2.25Cr-1Mo-0.25V钢材料和制造方面的规定,梳理总结了国内外专利商技术文件对2.25Cr-1Mo钢和2.25Cr-1Mo-0.25V钢焊材和母材在回火脆性、力学性能、再热裂纹等方面的要求。

  8. Distribution of trace elements in land plants and botanical taxonomy with special reference to rare earth elements and actinium

    Distribution profiles of trace elements in land plants were studied by neutron activation analysis and radioactivity measurements without activation. Number of botanical samples analyzed were more than three thousand in which more than three hundred botanical species were included. New accumulator plants of Co, Cr, Zn, Cd, rare earth elements, Ac, U, etc., were found. Capabilities of accumulating trace elements can be related to the botanical taxonomy. Discussions are given from view points of inorganic chemistry as well as from botanical physiology

  9. Structural phase change in Co{sub 2.25}Fe{sub 0.75}O{sub 4} spinel oxide by vacuum annealing and role of coexisting CoO phase on magnetic properties

    Bhowmik, R.N., E-mail: rnbhowmik.phy@pondiuni.edu.in [Department of Physics, Pondicherry University, R.V. Nagar, Kalapet, Pondicherry 605014 (India); Panda, Manas Ranjan [Department of Physics, Pondicherry University, R.V. Nagar, Kalapet, Pondicherry 605014 (India); Yusuf, S.M.; Mukadam, M.D. [Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India); Sinha, A.K. [Indus Synchrotrons Utilization Division, Raja Ramanna Centre for Advanced Technology, Indore 452013 (India)

    2015-10-15

    The spinel oxide Co{sub 2.25}Fe{sub 0.75}O{sub 4} has been prepared by co-precipitation route. The as prepared material has been annealed at 800 °C under vacuum. Properties of the samples annealed under vacuum have been compared with the sample annealed in air. Synchrotron X-ray diffraction, Raman spectroscopy and X-ray absorption near edge structure spectroscopy have been used for structural phase characterization. The cubic spinel structure in air annealed sample has been splitted into Co and Fe rich phases. The Co rich spinel phase has transformed into Cobalt monoxide (CoO) after vacuum annealing. This has resulted an increase of Fe:Co ratio in the Fe rich spinel phase. Raman spectra indicated a transformation of the distribution of Co and Fe ions from normal spinel like structure for the sample annealed in air to mixed spinel structure for the samples annealed under vacuum. The existence tetravalent Fe{sup 4+} ion has been confirmed in all the samples and it is new information for Co doped spinel ferrite system. All the samples exhibited ferrimagnetic behavior and exchange bias effect. The focus point is that vacuum annealing has been used as an effective route of material processing to control the structural phase and also, enhancement of magnetic properties in Co rich ferrite. - Graphical abstract: M(H) loop of vacuum annealed CoFe8V4 samples (a-e) and air annealed CoFe8A4 sample (f-g) at selected measurement temperatures. The variation of exchange bias field with temperatures for both the samples (h). - Highlights: • Structure and ferrimagnetic properties of Co{sub 2.25}Fe{sub 0.75}O{sub 4} have been reported. • Self-composite structure of material has been tailored by vacuum annealing. • Synchrotron X-ray diffraction and XANES have been used for characterization. • The existence tetravalent Fe{sup 4+} ions in ferrite structure is a new information. • The coexistence of CoO gives a great opportunity for tuning ferrimagnetic parameters.

  10. Molecular dynamics simulation and free energy landscape methods in probing L215H, L217R and L225M βI-tubulin mutations causing paclitaxel resistance in cancer cells.

    Tripathi, Shubhandra; Srivastava, Gaurava; Sharma, Ashok

    2016-08-01

    Drug resistance poses a threatening challenge for mankind, as the development of resistance to already well-established drugs causes serious therapeutic problems. Resistance to paclitaxel (Ptxl), a complex diterpenoid working as microtubule stabilizer, is one such issue in cancer treatment. Microtubule stabilizer drugs, stabilises microtubules upon binding to β-tubulin subunit of tubulin heterodimer thus causing mitotic arrest leading to death of cancer cell. Leucine point mutations viz. L215H, L217R, and L225M were reported for Ptxl resistance in various cancers. In the current study, molecular mechanism of these resistance causing mutations was explored using molecular docking, molecular dynamics (MD) simulation, binding energy estimation (MMPBSA), free energy decomposition, principle component analysis (PCA) and free energy landscape (FEL) methods. A total of five systems including unbound βI-tubulin (Apo), docked wild+Ptxl, L215H+Ptxl, L217R+Ptxl and L225M+Ptxl were prepared, and 50 ns MD simulation was performed for each system. Binding energy estimation indicated that leucine mutation reduces the binding affinity of Ptxl in mutant types (MTs) as compared to wild type (WT). Further, in contrast to WT Ptxl interactions with the M-loop (PHE270-VAL286), S6-S7 loop and H9-H10 were significantly altered in MTs. Results showed that in MTs, Ptxl had weak interaction with M-loop residues, while having strong affinity with S6-S7 loop and H6-H7 loop. Moreover, PCA and FEL analysis revealed that M-loop flexible region (THR274-LEU284) was strongly bound with Ptxl in WT preventing its flexible movement and the causing factor for microtubule stabilization. In MTs due to poor interaction with Ptxl, M-loop flexible region retains its flexibility, therefore unable to stabilize microtubule. This study will give an insight into the importance of M-loop flexible region interaction with Ptxl for microtubule stabilization. In addition, it clearly provides the molecular basis of

  11. Homogeneous Plastic Flow of Fully Amorphous and Partially Crystallized Zr41.2Ti13.8Cu12.5Ni10Be22.5 Bulk Metallic Glass

    Q.WANG; J.J. Blandin; M. Suery; B. Van de Moortéle; J.M. Pelletier

    2003-01-01

    The homogeneous plastic flow of fully amorphous and partially crystallized Zr41.2Ti13.8Cu12.5Ni10Be22.5 bulk metallic glass (Vit1) has been investigated by compression tests at high temperatures in supercooled liquid region. Experimental results show that at sufficiently low strain rates, the supercooled liquid of the fully amorphous alloy reveals Newtonian flow with a linear relationship between the flow stress and strain rate. As the strain rate is increased, a transition from linear Newtonian to nonlinear flow is detected, which can be explained by the transition state theory.Over the entire strain rate interval investigated, however, only nonlinear flow is present in the partially crystallized alloy, and the flow stress for each strain rate is much higher. It is found that the strain rate-stress relationship for the partially crystallized alloy at the given temperature of 646 K also obeys the sinh law derived from the transition state theory, similar to that of the initial homogeneous amorphous alloy. Thus, it is proposed that the flow behavior of the nanocrystalline/amorphous composite at 646 K is mainly controlled by the viscous flow of the remaining supercooled liquid.

  12. Effect of temper and hydrogen embrittlement on mechanical properties of 2,25Cr–1Mo steel grades – Application to Minimum Pressurizing Temperature (MPT) issues. Part II: Vintage reactors and MPT determination

    Standard and Vanadium-alloyed 2,25Cr–1Mo steel grades (EN 10028-2 12CrMo9-10/ASTM A387 gr. 22 and 13CrMoV9-10/ASTM A542 tp. D) are commonly used for the fabrication of heavy pressure vessels for applications in petroleum refining plants. These reactors are made of heavy plates, forged shells, forged nozzles and fittings. They are subjected to thermal cycles (stop and go) and to severe service conditions (high temperatures and high hydrogen partial pressures). A primary concern for end-users is the definition of the Minimum Pressurizing Temperature (MPT) of the equipment. This temperature is the lowest temperature at which the vessel can be repressurized after shutdown and insures no risk of brittle failure of the containment body. The MPT is defined by fracture mechanics and/or CVN approaches and calculations. This second part of the paper presents the methodology of MPT determination and the particular case of vintage reactors. MPT determination methodology is explained by using a virtual pressure vessel representative of vessels found in petroleum refineries. A special focus is also set on the evolution of embedded defects

  13. Effect of temper and hydrogen embrittlement on mechanical properties of 2,25Cr–1Mo steel grades – Application to Minimum Pressurizing Temperature (MPT) issues. Part I: General considerations and materials' properties

    Standard and Vanadium-alloyed 2,25Cr–1Mo steel grades (EN 10028-2 12CrMo9-10/ASTM A387 gr. 22 and 13CrMoV9-10/ASTM A542 tp. D) are commonly used for the fabrication of heavy pressure vessels for applications in petroleum refining plants. These reactors are made of heavy plates, forged shells, forged nozzles and fittings. They are subjected to thermal cycles (stop and go) and to severe service conditions (high temperatures and high hydrogen partial pressures). A primary concern for end-users is the definition of the Minimum Pressurizing Temperature (MPT) of the equipment. This temperature is the lowest temperature at which the vessel can be repressurized after shutdown and insures no risk of brittle failure of the containment body. The MPT is defined by fracture mechanics and/or CVN approaches and calculations. This first part of the paper presents the impact of thermal aging and exposure to hydrogen on materials' mechanical properties and consequently on the value of MPT

  14. Hemispherical total emissivity and specific heat capacity of deeply undercooled Zr41.2Ti13.8Cu12.5Ni10.0Be22.5 melts

    High-temperature high-vacuum electrostatic levitation (HTHVESL) and differential scanning calorimetry (DSC) were combined to determine the hemispherical total emissivity εT, and the specific heat capacity cp, of the undercooled liquid and throughout the glass transition of the Zr41.2Ti13.8Cu12.5Ni10.0Be22.5 bulk metallic glass forming alloy. The ratio of cp/εT as a function of undercooling was determining from radiative cooling curves measured in the HTHVESL. Using specific heat capacity data obtained by DSC investigations close to the glass transition and above the melting point, εT and cp were separated and the specific heat capacity of the whole undercooled liquid region was determined. Furthermore, the hemispherical total emissivity of the liquid was found to be about 0.22 at 980 K. On undercooling the liquid, the emissivity decreases to approximately 0.18 at about 670 K, where the undercooled liquid starts to freeze to a glass. No significant changes of the emissivity are observed as the alloy undergoes the glass transition. copyright 1995 American Institute of Physics

  15. Measurement of inclusive ep cross sections at high Q{sup 2} at √(s) = 225 and 252 GeV and of the longitudinal proton structure function F{sub L} at HERA

    Andreev, V.; Belousov, A.; Fomenko, A.; Gogitidze, N.; Lebedev, A.; Malinovski, E.; Rusakov, S.; Vazdik, Y. [Lebedev Physical Institute, Moscow (Russian Federation); Baghdasaryan, A.; Baghdasaryan, S.; Zohrabyan, H. [Yerevan Physics Institute, Yerevan (Armenia); Begzsuren, K.; Ravdandorj, T.; Tseepeldorj, B. [Institute of Physics and Technology of the Mongolian Academy of Sciences, Ulaanbaatar (Mongolia); Belov, P.; Brinkmann, M.; Britzger, D.; Campbell, A.J.; Dodonov, V.; Eckerlin, G.; Elsen, E.; Fleischer, M.; Gayler, J.; Ghazaryan, S.; Glazov, A.; Gouzevitch, M.; Grebenyuk, A.; Habib, S.; Haidt, D.; Kleinwort, C.; Krueger, K.; Levonian, S.; Lipka, K.; List, B.; List, J.; Lobodzinski, B.; Meyer, A.B.; Meyer, J.; Niebuhr, C.; Olsson, J.E.; Ozerov, D.; Pahl, P.; Petrukhin, A.; Pirumov, H.; Pitzl, D.; Placakyte, R.; Radescu, V.; Raspereza, A.; Schmitt, S.; Sefkow, F.; Shushkevich, S.; South, D.; Steder, M.; Wuensch, E. [DESY, Hamburg (Germany); Boudry, V.; Specka, A. [LLR, Ecole Polytechnique, CNRS/IN2P3, Palaiseau (France); Bradt, G. [Oxford University, Department of Physics, Oxford (United Kingdom); Brisson, V.; Jacquet, M.; Pascaud, C.; Zhang, Z.; Zomer, F. [LAL, Universite Paris-Sud, CNRS/IN2P3, Orsay (France); Buniatyan, A.; Huber, F.; Sauter, M.; Schoening, A. [Universitaet Heidelberg, Physikalisches Institut, Heidelberg (Germany); Bylinkin, A.; Bystritskaya, L.; Fedotov, A.; Rostovtsev, A. [Institute for Theoretical and Experimental Physics, Moscow (Russian Federation); Cantun Avila, K.B.; Contreras, J.G. [CINVESTAV, Departamento de Fisica Aplicada, Merida, Yucatan (Mexico); Ceccopieri, F.; Wolf, E.A. de; Favart, L.; Hreus, T.; Janssen, X.; Roosen, R.; Mechelen, P. van [Brussels and Universiteit Antwerpen, Inter-University Institute for High Energies ULB-VUB, Antwerp (Belgium); Cerny, K.; Pokorny, B.; Polifka, R.; Salek, D.; Valkarova, A.; Zacek, J.; Zlebcik, R. [Charles University, Faculty of Mathematics and Physics, Prague (Czech Republic); Chekelian, V.; Grindhammer, G.; Kiesling, C.; Olivier, B. [Max-Planck-Institut fuer Physik, Munich (Germany); Dainton, J.B.; Gabathuler, E.; Greenshaw, T.; Klein, M.; Kretzschmar, J.; Laycock, P.; Maxfield, S.J.; Mehta, A.; Patel, G.D. [University of Liverpool, Department of Physics, Liverpool (United Kingdom); Daum, K.; Meyer, H. [Universitaet Wuppertal, Fachbereich C, Wuppertal (Germany); Diaconu, C.; Hoffmann, D.; Sauvan, E.; Vallee, C. [CPPM, Aix-Marseille Univ, CNRS/IN2P3, Marseille (France); Dobre, M.; Rotaru, M. [National Institute for Physics and Nuclear Engineering (NIPNE), Bucharest (Romania); Dossanov, A. [Universitaet Hamburg, Institut fuer Experimentalphysik, Hamburg (Germany); Max-Planck-Institut fuer Physik, Munich (Germany); Dubak, A. [Max-Planck-Institut fuer Physik, Munich (Germany); University of Montenegro, Faculty of Science, Podgorica (Montenegro); Egli, S.; Hildebrandt, M.; Horisberger, R. [Paul Scherrer Institut, Villigen (Switzerland); Feltesse, J.; Perez, E.; Schoeffel, L. [CEA, DSM/Irfu, CE-Saclay, Gif-sur-Yvette (France); Ferencei, J. [Slovak Academy of Sciences, Institute of Experimental Physics, Kosice (Slovakia); Goerlich, L.; Mikocki, S.; Nowak, G.; Sopicki, P.; Turnau, J. [Institute for Nuclear Physics, Cracow (Poland); Grab, C. [ETH, Institut fuer Teilchenphysik, Zurich (Switzerland); Henderson, R.C.W. [University of Lancaster, Department of Physics, Lancaster (United Kingdom); Herbst, M.; Jung, A.W.; Schultz-Coulon, H.C. [Universitaet Heidelberg, Kirchhoff-Institut fuer Physik, Heidelberg (Germany); Hladka, J.; Reimer, P. [Academy of Sciences of the Czech Republic, Institute of Physics, Prague (Czech Republic); Jung, H. [Brussels and Universiteit Antwerpen, Inter-University Institute for High Energies ULB-VUB, Antwerp (Belgium); DESY, Hamburg (Germany); Kapichine, M.; Morozov, A.; Spaskov, V. [Joint Institute for Nuclear Research, Dubna (RU); Kogler, R.; Nowak, K. [Universitaet Hamburg, Institut fuer Experimentalphysik, Hamburg (DE); Kostka, P.; Lange, W.; Naumann, T. [DESY, Zeuthen (DE); Landon, M.P.J.; Rizvi, E.; Traynor, D. [University of London, School of Physics and Astronomy, Queen Mary, London (GB); Lubimov, V. [Institute for Theoretical and Experimental Physics, Moscow (RU); Martyn, H.U. [I. Physikalisches Institut der RWTH, Aachen (DE); Mueller, K.; Robmann, P.; Straumann, U.; Truoel, P. [Physik-Institut der Universitaet Zuerich, Zurich (CH); Newman, P.R.; Thompson, P.D. [School of Physics and Astronomy, University of Birmingham, Birmingham (GB); Picuric, I.; Raicevic, N. [University of Montenegro, Faculty of Science, Podgorica (ME); Sankey, D.P.C. [STFC, Rutherford Appleton Laboratory, Oxfordshire (GB); Soloviev, Y. [DESY, Hamburg (DE); Lebedev Physical Institute, Moscow (RU); Stella, B. [Universita di Roma Tre (IT); INFN Roma 3, Dipartimento di Fisica, Rome (IT); Sykora, T. [Brussels and Universiteit Antwerpen, Inter-University Institute for High Energies ULB-VUB, Antwerp (BE); Charles University, Faculty of Mathematics and Physics, Prague (CZ); Tsakov, I. [Institute for Nuclear Research and Nuclear Energy, Sofia (BG); Wegener, D. [Institut fuer Physik, TU Dortmund, Dortmund (DE); Collaboration: H1 Collaboration

    2014-04-15

    Inclusive ep double differential cross sections for neutral current deep inelastic scattering are measured with the H1 detector at HERA.The data were taken with a lepton beam energy of 27.6 GeV and two proton beam energies of E{sub p} = 460 and 575 GeV corresponding to centre-of-mass energies of 225 and 252 GeV, respectively. The measurements cover the region of 6.5 x 10{sup -4} ≤ x ≤ 0.65 for 35 ≤ Q{sup 2} ≤ 800 GeV{sup 2} up to y = 0.85. The measurements are used together with previously published H1 data at E{sub p} = 920 GeV and lower Q{sup 2} data at E{sub p} = 460, 575 and 920 GeV to extract the longitudinal proton structure function F{sub L} in the region 1.5 ≤ Q{sup 2} ≤ 800 GeV{sup 2}. (orig.)

  16. Crystallization and soft magnetic properties of rapidly solidified Fe73.5Nb3Cu1Si22.5-XBX (X=5, 9, 10, 11.25, 19) alloys

    The metalloids Si and B in the melt-spun Fe73.5Nb3Cu1Si22.5-XBX (X=5, 9, 10, 11.25, 19) alloys play a major role in their crystallization and magnetic behaviour. In the present work, the effect of nanocrystallization on the transport properties was studied using thermal variation of electrical resistivity. An X-ray diffractogram study showed that the formation of different phases was controlled by the metalloid content in the alloy. Nanocrystalline α-Fe(Si) and/or Fe3Si particles were formed in all the measured alloys except the alloy with 19 at% boron where α-Fe phase appeared. The lattice parameter as well as Si content within α-Fe(Si) was also found to depend on the metalloid content of the alloy. The Debye temperature was derived from thermal electrical resistivity study and was found to depend on the metalloid content of the alloys. However, Curie temperature of these alloys was not strongly dependent on the metalloid. The formation of α-Fe(Si) and/or Fe3Si nanoparticles was responsible for the superior soft magnetic properties of the 9 at% boron alloy annealed around 800 K. The early appearance of boride phases, which have high magnetocrystalline anisotropy, was the cause of deterioration in soft magnetic properties in X=5, 10, 11.25 and 19 alloys

  17. 2012年ENR全球最大225家国际承包商榜单出炉——中国建筑企业比肩国际一流尚须努力

    汪红蕾

    2012-01-01

    日前,美国麦格劳一希尔建筑信息公司(McGraw—Hill)发布了2012年Engineering News—Record(简称ENR)全球最大225家国际承包商榜单。中国对外承包工程商会新闻发言人张湘告诉记者,我国内地共有52家企业上榜。其中江苏南通六建集团有限公司等7家公司为新上榜企业,上榜企业比去年增加2家。但多项数据显示,国内企业对外承包业务运作水平与国际一流企业相比还存在很大差距。

  18. Effects of partial Co replacement by Fe in Sr0.775Y0.225CoO3-δ on its magnetic property, oxygen deficiency and crystal structure

    Sutjahja I.M.

    2015-09-01

    Full Text Available A study has been conducted on the effects of partial, 10 % Co substitution by Fe in the perovskite Sr0.775Y0.225CoO3-δ compound. The XRD data show that the resulted samples of Fe-free and Fe-doped compounds exhibit good 314 single phase quality with a tetragonal I4/mmm crystal structure. The measured M-T curves display the typical feature of ferromagnetic (FM transition at 335 K for the Fe-free sample, while showing significantly degraded FM ordering for the 10 % Fe-doped sample. The oxygen deficiency determined fro|m our 10 % Fe doped sample is found to decrease by only 0.025. Further detailed analysis of the XRD data also reveals distinctly different structural changes in the Co-O slabs compared to the 50 % Fe-doped sample which exhibits a complete suppression of FM order. The results of this study, thus, have revealed the close relations among the changes induced by Fe doping in the magnetic ordering of crystal, and its oxygen content as well as the associated local structure in the Co-O layers responsible for the magnetic properties in the compound.

  19. Synthesis and characterization of copper fiber reinforced Zr41.2Ti13.8Cu12.5Ni10.0Be22.5 bulk metallic glass

    Highly conductive Cu fibers were introduced into Zr41.2Ti13.8Cu12.5Ni10Be22.5 (Vitreloy1) Bulk Metallic Glass (BMG) of poor conductivity to produce a composite with a thermal anisotropy. The composites with circular and square cross-sections with the volume fraction ranging from 7 to 60% were processed successfully by pressure-gravity infiltration. Differential Scanning Calorimetry (DSC) showed that the BMG matrix remained predominantly amorphous after adding up to 60 vol.% of Cu fibers. The limited crystallization at the Cu/Vitreloy1 interface was observed under optical microscope. This crystallization is attributed to heterogeneous nucleation starting from the Cu/Vitreloy1 interface followed by the growth in the region with higher Cu concentration around the copper fibers. A combination of two-dimensional triangular and square ordering of the fibers was observed in the composite samples. X-ray diffraction patterns of the composites showed the peaks from the reinforced fibers and crystals around the Cu/Vitreloy1 interface superimposed on the broad diffuse maxima from the amorphous phase. Best processing parameters in terms of processing time and temperature were determined for the composite reinforced with 60 vol.% fibers

  20. Carbon Dioxide, Hydrographic, and Chemical Data Obtained During the R/V Meteor Cruise 22/5 in the South Atlantic Ocean (WOCE Section A10, December 1992-January 1993)

    Kozyr, A.

    1998-12-01

    This data documentation discusses the procedures and methods used to measure total carbon dioxide (TCO{sub 2}) and total alkalinity (TALK) at hydrographic stations, as well as the underway partial pressure of CO{sub 2} (pCO{sub 2}) during the R/V Meteor Cruise 22/5 in the South Atlantic Ocean (Section A10). Conducted as part of the World Ocean Circulation Experiment (WOCE), the cruise began in Rio de Janeiro on December 27, 1992, and ended after 36 days at sea in Capetown, South Africa, on January 31, 1993. Measurements made along WOCE Section A10 included pressure, temperature, and salinity [measured by conductivity, temperature, and depth (CTD) sensor], bottle salinity, bottle oxygen, phosphate, nitrate, nitrite, silicate, chlorofluorocarbons (CFC-1 1 , CFC-12), TCO{sub 2}, TALK, and underway pCO{sub 2}. The TCO{sub 2} was measured by using two Single-Operator Multiparameter Metabolic Analyzers (SOMMAs) for extracting CO{sub 2} from seawater samples that were coupled to a coulometer for detection of the extracted CO{sub 2}. The overall precision and accuracy of the analyses was {+-} 1.9 {micro}mol/kg. Samples collected for TALK were measured by potentiometric titration; precision was {+-}2.0 {micro}mol/kg. Underway pCO{sub 2} was measured by infrared photometry with a precision of {+-} 2.0 {micro}atm. The work aboard the R/V Meteor was supported by the U.S. Department of Energy under contract DE-AC02-76CHOO016, and the Bundesministerium fir Forschung und Technologies through grants 03F0545A and MPG 099/1.

  1. THE FIRST Hi-GAL OBSERVATIONS OF THE OUTER GALAXY: A LOOK AT STAR FORMATION IN THE THIRD GALACTIC QUADRANT IN THE LONGITUDE RANGE 216. Degree-Sign 5 {approx}< l {approx}< 225. Degree-Sign 5

    Elia, D.; Molinari, S.; Schisano, E.; Pestalozzi, M.; Benedettini, M.; Di Giorgio, A. M.; Pezzuto, S.; Rygl, K. L. J. [Istituto di Astrofisica e Planetologia Spaziali-INAF, Via Fosso del Cavaliere 100, I-00133 Roma (Italy); Fukui, Y.; Hayakawa, T.; Yamamoto, H. [Department of Physics, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602 (Japan); Olmi, L. [Osservatorio Astrofisico di Arcetri-INAF, Largo E. Fermi 5, I-50125 Firenze (Italy); Veneziani, M. [Infrared Processing and Analysis Center, California Institute of Technology, Pasadena, CA 91125 (United States); Schneider, N.; Piazzo, L. [IRFU/SAp CEA/DSM, Laboratoire AIM CNRS, Universit Paris Diderot, F-91191 Gif-sur-Yvette (France); Ikhenaode, D. [DIET-Dipartimento di Ingegneria dell' Informazione, Elettronica e Telecomunicazioni, Universita di Roma La Sapienza, via Eudossina 18, I-00184 Roma (Italy); Mizuno, A. [Solar-Terrestrial Environment Laboratory, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Onishi, T. [Department of Physical Science, Osaka Prefecture University, Sakai, Osaka 599-8531 (Japan); Polychroni, D. [Department of Astrophysics, Astronomy and Mechanics, Faculty of Physics, University of Athens, Panepistimiopolis, 15784 Zografos, Athens (Greece); Maruccia, Y., E-mail: davide.elia@iaps.inaf.it [Dipartimento di Matematica e Fisica, Universita del Salento, CP 193, I-73100 Lecce (Italy)

    2013-07-20

    We present the first Herschel PACS and SPIRE photometric observations in a portion of the outer Galaxy (216. Degree-Sign 5 {approx}< l {approx}< 225. Degree-Sign 5 and -2 Degree-Sign {approx}< b {approx}< 0 Degree-Sign ) as a part of the Hi-GAL survey. The maps between 70 and 500 {mu}m, the derived column density and temperature maps, and the compact source catalog are presented. NANTEN CO(1-0) line observations are used to derive cloud kinematics and distances so that we can estimate distance-dependent physical parameters of the compact sources (cores and clumps) having a reliable spectral energy distribution that we separate into 255 proto-stellar and 688 starless sources. Both typologies are found in association with all the distance components observed in the field, up to {approx}5.8 kpc, testifying to the presence of star formation beyond the Perseus arm at these longitudes. Selecting the starless gravitationally bound sources, we identify 590 pre-stellar candidates. Several sources of both proto- and pre-stellar nature are found to exceed the minimum requirement for being compatible with massive star formation based on the mass-radius relation. For the pre-stellar sources belonging to the Local arm (d {approx}< 1.5 kpc) we study the mass function whose high-mass end shows a power law N(log M){proportional_to}M {sup -1.0{+-}0.2}. Finally, we use a luminosity versus mass diagram to infer the evolutionary status of the sources, finding that most of the proto-stellar sources are in the early accretion phase (with some cases compatible with a Class I stage), while for pre-stellar sources, in general, accretion has not yet started.

  2. 49 CFR 192.225 - Welding procedures.

    2010-10-01

    ... qualified under section 5 of API 1104 (incorporated by reference, see § 192.7) or section IX of the ASME... § 192.7) to produce welds meeting the requirements of this subpart. The quality of the test welds...

  3. 225-B ion exchange piping design documentation

    Prather, M.C. [ICF Kaiser Hanford Co., Richland, WA (United States)

    1996-02-01

    This document describes the interface between the planned permanent ion exchange piping system and the planned portable ion exchange system. This is part of the Waste Encapsulation and Storage Facility (WESF). In order to decouple this WESF from B-Plant and to improve recovery from a capsule leak, contaminated pool cell water will be recirculated through a portable ion exchange resin system.

  4. QTL Information Table: 225 [Q-TARO

    Full Text Available Resistance or Tolerance Blast resistance Neck blast incidence at Kampangsaen (1998) Mixture C)Inte...A., Pa-In, N., Vongsaprom, C., and Toojinda, T. (2002). Quantitative Trait Loci Associated with Leaf and Neck Blast Resistanc...DNA Res 9, 79-88. http://dnaresearch.oxfordjournals.org/cgi/content/abstract/9/3/79 ... ...e in Recombinant Inbred Line Population of Rice (Oryza Sativa).

  5. 7 CFR 225.17 - Procurement standards.

    2010-01-01

    ... Procurement standards. (a) State agencies and sponsors shall comply with the requirements of 7 CFR part 3016 or 7 CFR part 3019, as applicable, concerning the procurement of supplies, food, equipment and other...) Procurements by public sponsors comply with applicable State or local laws and the standards set forth in 7...

  6. 7 CFR 225.2 - Definitions.

    2010-01-01

    ... 131.200), (21 CFR 131.203), (21 CFR 131.206), respectively. 7 CFR part 3015 means the Uniform Federal... organizations under Department programs. 7 CFR part 3019 means the Department's Uniform Administrative... which at least 50 percent of the children are eligible for free or reduced-price school meals under...

  7. 225-B ion exchange piping design documentation

    This document describes the interface between the planned permanent ion exchange piping system and the planned portable ion exchange system. This is part of the Waste Encapsulation and Storage Facility (WESF). In order to decouple this WESF from B-Plant and to improve recovery from a capsule leak, contaminated pool cell water will be recirculated through a portable ion exchange resin system

  8. 49 CFR 225.5 - Definitions.

    2010-10-01

    ... Occupational Safety and Health Administration standard in 29 CFR part 1910 in effect during calendar year 2002..., repair or maintenance facility, major switching yard or terminal. For employees who are engaged in... compared to the number of days already reported. Significant illness means an illness involving cancer or...

  9. 7 CFR 225.3 - Administration.

    2010-01-01

    ... disbursements to public schools within the State by the State educational agency. (c) Regional office... (7 CFR part 15) issued under title VI of the Civil Rights Act of 1964, and any Instructions issued...

  10. 2 CFR 225.10 - Authority.

    2010-01-01

    ... authority of the Budget and Accounting Act of 1921, as amended; the Budget and Accounting Procedures Act of 1950, as amended; the Chief Financial Officers Act of 1990; Reorganization Plan No. 2 of 1970; and... Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE Reserved COST PRINCIPLES FOR STATE,...

  11. 22 CFR 225.107 - IRB membership.

    2010-04-01

    ... review of research activities commonly conducted by the institution. The IRB shall be sufficiently... consideration of race, gender, and cultural backgrounds and sensitivity to such issues as community attitudes... the institution's consideration of qualified persons of both sexes, so long as no selection is made...

  12. 48 CFR 225.7403-1 - General.

    2010-10-01

    ..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Defense Contractors Outside the United... policy for contracts that require performance or travel outside the United States can be obtained...

  13. 48 CFR 225.7003-1 - Definitions.

    2010-10-01

    ...) Automotive item— (1) Means a self-propelled military transport tactical vehicle, primarily intended for use by military personnel or for carrying cargo, such as— (i) A high-mobility multipurpose wheeled..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Authorization Acts, Appropriations Acts,...

  14. 12 CFR 225.2 - Definitions.

    2010-01-01

    ... have the same meanings as provided in § 211.21(n) and § 211.23 of the Board's Regulation K (12 CFR 211... of the Board's Regulation K (12 CFR 211.21), has adopted capital standards consistent in all respects... under section 10(l) of the Home Owners Loan Act. (n) Shareholder—(1) Controlling shareholder means...

  15. Synthesis and crystal structure of new layered perovskite compounds: Li2La0.833(Nb1.5Ti0.5)O7 and Li2La2.25(Nb1.25Ti2.75)O13

    Single crystals of Li2La0.833(Nb1.5Ti0.5)O7 and Li2La2.25(Nb1.25Ti2.75)O13 were grown in the system Li2O-La2O3-Nb2O5-TiO2. Both these compounds crystallize in the space group P42/mmm (No 136), Z = 4: a = 5.5334(2), c = 18.3907(2) angstrom and a = 5.4915(6), and c = 33.812(4) angstrom, respectively. Their crystal structures, determined from single crystal X-ray diffraction data, are related to the Ruddlesden-Popper phases An+1BnO3n+1, which could be better written here as Li2[AxBnO3n+1]: Li2La0.833(Nb1.5Ti0.5)O7 is an n = 2 member and Li2La2.25(Nb1.25Ti2.75)O13 corresponds to an n = 4 member. In both structures, Nb5+ and Ti4+ ions statistically occupy distorted B octahedral sites of the perovskite, La3+ ions partially fill the cages of the perovskite, and Li+ ions are found in tetrahedral coordination between the perovskite layers

  16. Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization.

    Jaspreet Singh Jaggi

    Full Text Available BACKGROUND: Abnormal regulation of angiogenesis in tumors results in the formation of vessels that are necessary for tumor growth, but compromised in structure and function. Abnormal tumor vasculature impairs oxygen and drug delivery and results in radiotherapy and chemotherapy resistance, respectively. Alpha particles are extraordinarily potent, short-ranged radiations with geometry uniquely suitable for selectively killing neovasculature. METHODOLOGY AND PRINCIPAL FINDINGS: Actinium-225 ((225Ac-E4G10, an alpha-emitting antibody construct reactive with the unengaged form of vascular endothelial cadherin, is capable of potent, selective killing of tumor neovascular endothelium and late endothelial progenitors in bone-marrow and blood. No specific normal-tissue uptake of E4G10 was seen by imaging or post-mortem biodistribution studies in mice. In a mouse-model of prostatic carcinoma, (225Ac-E4G10 treatment resulted in inhibition of tumor growth, lower serum prostate specific antigen level and markedly prolonged survival, which was further enhanced by subsequent administration of paclitaxel. Immunohistochemistry revealed lower vessel density and enhanced tumor cell apoptosis in (225Ac-E4G10 treated tumors. Additionally, the residual tumor vasculature appeared normalized as evident by enhanced pericyte coverage following (225Ac-E4G10 therapy. However, no toxicity was observed in vascularized normal organs following (225Ac-E4G10 therapy. CONCLUSIONS: The data suggest that alpha-particle immunotherapy to neovasculature, alone or in combination with sequential chemotherapy, is an effective approach to cancer therapy.

  17. Mitotic effects of monochromatic ultraviolet radiation at 225, 265, and 280 nm on eleven stages of the cell cycle of the grasshopper neuroblast in culture. II. Changes in progression rate and cell sequence between the stage irradiated and nuclear membrane breakdown

    Portions of embryos of the grasshopper, Chortophaga viridifasciata (DeGeer), were cultured in hanging drops under quartz cover slips. Immediately after exposure to 225, 265, or 280 nm radiation, microscope observations at 380C were begun. The morphologically identified stage and the time after treatment of selected neuroblasts were recorded at short-time intervals until prometaphase was reached. Mitotic retardation induced by irradiation of prereplication stages (metaphase, anaphase, or early telophase) or S phase (middle or late telophase, interphase, or very early prophase) is greatest in postreplication stages (early, middle, and late prophase) and absent or minimal in stages morphologically identified as parts of S phase. Ultraviolet irradiation superimposes on the normal diversity of progression rates an additional variation factor, so that cells do not necessarily reach prometaphase in the order of their sequence at the time of treatment. This suggests the need for caution in ascribing particular radiosensitivities to substages of limited duration on the basis of the order in which they attain a subsequent stage

  18. Dicty_cDB: VFA225 [Dicty_cDB

    Full Text Available 6194.1 D. discoideum mRNA for ribosomal acidic phosphoprotein P0. 1294 0.0 3 CD203589 |CD203589.1 Ls_AM1_10H07_T7 Litomosoides sigmo...dontis adult male 1 Litomosoides sigmodontis cDNA clone Ls_AM1_10H07 5', mRNA sequen... Value ( P22685 ) RecName: Full=60S acidic ribosomal protein P0; 419 e-134 R5DOP0( S14012 ) ribosomal protein P0 - slime mo...ic r... 223 1e-56 (Q9U3U0) RecName: Full=60S acidic ribosomal protein P0; ... 214 8e-56 AJ457827_1( AJ457827 |pid:none) Bombyx mo...AGACYSPSISEEDFINKFKQGIFNIAAISLEIG YPTVASIPHSVMNAFKNLLAISFETSYTFDAAEKFKSAAAAAPVAAAPSAAAPAAAAXKV VVEEKKEESDDDM

  19. Dicty_cDB: SLF225 [Dicty_cDB

    Full Text Available * ilnyneiiffqfskkkkkkkkkkkkkkkkk Frame C: *qfys*fwl*fqsxmlntnshhhlkihhqmiqiak*lvhnhtl--- ---wyfrrfwfrfrfrfrlr*rfrfrfrccqwftir...frccqwftirfrcc*wftiwcpnw ftircw*cfrcfhw*piwfsisrn*ywfiiqw*w*wcpn

  20. 12 CFR 225.66 - Professional association membership; competency.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Professional association membership; competency...; competency. (a) Membership in appraisal organizations. A State certified appraiser or a State licensed...) Competency. All staff and fee appraisers performing appraisals in connection with federally...

  1. 22 CFR 225.116 - General requirements for informed consent.

    2010-04-01

    ... is voluntary, refusal to participate will involve no penalty or loss of benefits to which the subject... authority of a physician to provide emergency medical care, to the extent the physician is permitted to...

  2. 6 CFR 27.225 - Site security plans.

    2010-01-01

    ... Vulnerability Assessment, and identify and describe the security measures to address each such vulnerability; (2) Identify and describe how security measures selected by the facility will address the applicable risk-based... updates, revises or otherwise alters its Security Vulnerability Assessment pursuant to § 27.215(d),...

  3. 48 CFR 225.7703-4 - Reporting requirement.

    2010-10-01

    ... reports to the Deputy Director, Contingency Contracting & Acquisition Policy, Defense Procurement and... Navy. (d) The Department of the Air Force. (e) The Defense Logistics Agency. (f) The other...

  4. 7 CFR 2.25 - Assistant Secretary for Civil Rights.

    2010-01-01

    ... authority: (i) To perform the functions and responsibilities of that position under 29 CFR part 1614... basis of sex in USDA education programs and activities funded by the Department. (iv) Actions to enforce... mission area outreach programs. (iii) Coordinate the dissemination/communication of all...

  5. The Physical Protection Convention, security fundamentals and INFCIRC/225

    Full text: In the year 1999 there were 504 different fuel cycle facilities worldwide, out of these 250 were in operation (58 uranium mills, 31 conversion plants, 22 enrichment plants, 49 fuel fabrication plants, 67 interim storage facilities, 13 reprocessing plants and 10 MOX plants). At the end of year 2000 there were 438 power reactors operating. At the same period there were also 260 research reactors in shutdown state but not decommissioned and 278 research reactors were in operation. Nuclear materials in all these facilities and during transport could be potential target for theft or sabotage as well as these facilities could be potential targets for sabotage. Threats involving theft of nuclear material constitute a clear proliferation risk, and sabotage of nuclear material and nuclear facilities may have radiological consequences for the public and the environment. The risk imposed by criminal, including terrorist activities, both as regards theft of nuclear material and sabotage of nuclear material or nuclear facilities, needs to be taken seriously, and as far as possible, prevented. This situation is not new and special care is taken by States to protect and safeguard nuclear material and fuel cycle facilities under their jurisdiction. Despite this during the last decade illicit trafficking occurs as can be observed from the IAEA Illicit Trafficking Data Base. Although the responsibility for establishing comprehensive system for the protection of nuclear material and nuclear facilities in a State rests with that State, it is also a matter of international concern. The IAEA involvement and guidance in this area is very important and is directed from safeguards and safety perspective. (author)

  6. 47 CFR 76.225 - Commercial limits in children's programs.

    2010-10-01

    ... purposes, including either e-commerce or advertising; (3) The Web site's home page and other menu pages are... site to which viewers are directed by the Web site address is not used for e-commerce, advertising, or other commercial purposes (e.g., contains no links labeled “store” and no links to another page...

  7. 45 CFR 225.3 - Federal financial participation.

    2010-10-01

    ... under title IV-B of the Act, Federal financial participation in expenditures for the recruitment, selection, training, and employment and other use of subprofessional staff and volunteers is available...

  8. Dicty_cDB: VHE225 [Dicty_cDB

    Full Text Available fsbb001f209i23k0 Sorghum methylation filtered library (LibID: 104) Sorghum bicolor genomic clone fsbb001f20...9i23, genomic survey sequence. 46 1.1 1 CW460858 |CW460858.1 fsbb001f208d23f0 Sorghum methylation filtered l...sequence. 46 1.1 1 CW425989 |CW425989.1 fsbb001f137c21k0 Sorghum methylation filtered library (LibID: 104) S...10810834_148_31806_130 Sorghum methylation-filtered library (LibID: 104) Sorghum bicolor genomic clone 10810

  9. Metal hydrogen sulfide critical temperature at the pressure 225 gpa

    Kudryashov, Nikolay; Kutukov, Alexander; Mazur, Evgeny

    2016-01-01

    \\'Eliashberg theory, being generalized to the electron-phonon (EP) systems with not constant density of electronic states, as well as to the frequency behavior of the renormalization of both the electron mass and the chemical potential, is used to study hydrogen sulphide phase under pressure. The phonon contribution to the anomalous electron Green's function (GF) is considered. The pairing is considered within the overall width of the electron band, and not only in a narrow layer at the Fermi...

  10. 40 CFR 265.225 - Waste analysis and trial tests.

    2010-07-01

    ... (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... the different process: (i) Conduct waste analyses and trial treatment tests (e.g., bench scale or... waste under similar operating conditions; to show that this treatment will comply with § 265.17(b). (b)...

  11. 7 CFR 225.14 - Requirements for sponsor participation.

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SUMMER FOOD SERVICE PROGRAM Sponsor and Site Provisions...) Document that the site is not a residential child-care institution as defined in paragraph (c) of the... and authority over the operation of the Program at all sites under its sponsorship; (iv)...

  12. 49 CFR 234.225 - Activation of warning system.

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SIGNAL SYSTEM SAFETY AND STATE ACTION PLANS...-rail grade crossing warning system shall be maintained to activate in accordance with the design of the... operation of through trains before the grade crossing is occupied by rail traffic....

  13. Eurodif plant 225-kV supply cables

    Details are given about the characteristics of the low-density polyethylene insulated cables installed at Tricastin. The reasons for choosing this solution are analysed in particular as concerns fire hazards. The patterns adopted for the installation of these cables are described

  14. Epoxy injection repairs to concrete in 225-B Building

    Vollert, F.R.

    1996-09-19

    In 1982, the damaged anchor areas (67 total) in the Operating Gallery and cold manipulator shop ceiling reinforced concrete slabs were epoxy injection repaired by Construction Technology Laboratories (CTL), Portland Cement Association. The through depth vertical cracks (10 total) in the ceiling slabs in the galleries and manipulator shops were sealed and structurally repaired using epoxy injection procedures. The details of the epoxy reRair are reported. Sonic nondestructive (NDT) testing before and after the epoxy injection repairs were made by CTL to confirm that the repairs are structurally effective. CTL recommended to expedite the installation of lateral bracing for the manipulator monorail in order to avoid re-darnage to the repaired anchor areas.

  15. 48 CFR 252.225-7021 - Trade agreements.

    2010-10-01

    ...)). These exclusions presently consist of— (A) Textiles, apparel articles, footwear, handbags, luggage, flat goods, work gloves, leather wearing apparel, and handloomed, handmade, or folklore articles that are...

  16. 12 CFR 225.42 - Transactions not requiring prior notice.

    2010-01-01

    ... after the meeting; (6) Stock dividends. The receipt of voting securities of a state member bank or bank holding company through a stock dividend or stock split if the proportional interest of the recipient...

  17. 7 CFR 225.15 - Management responsibilities of sponsors.

    2010-01-01

    ... without regard to race, color, national origin, sex, age, or handicap. (f) Application for free Program... reduced price meal eligibility information to certain programs and individuals without parental consent... eligible for free and reduced price meals to any party without parental notification and consent...

  18. 45 CFR 225.2 - State plan requirements.

    2010-10-01

    ... under titles I, X, XIV, or XVI (AABD) of the Social Security Act for Guam, Puerto Rico and the Virgin... employment of persons of low income and little or no formal education, including employment of young...

  19. 7 CFR 225.16 - Meal service requirements.

    2010-01-01

    ... (large) or 1/2. Cooked dry beans or peas or 1/4 cup. Peanut butter or an equivalent quantity of any... ounces. Cheese or 2 ounces. Egg (large) or 1. Cooked dry beans or peas or 1/2 cup. 2 Peanut butter or... dry beans or peas or 1/4 cup 2. Peanut butter or soynut butter or other nut or seed butters or...

  20. Study on laser atomic spectroscopy

    Laser atomic spectroscopic study on actinium element has been performed in many areas of spectroscopy. The study on characteristic of atomic vapor has been proceeded for copper atom and the spatial density distribution of copper vapor is measured. This experimental data has been compared with the theoretically calculated data. In spectroscopic experiment, the first and second excited states for actinium element are identified and the most efficient ionization scheme for actinium element is identified. In addition, the corrosion problem for filament material due to the heating of the actinium element has been studied. (Author)

  1. TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

    As part of its commitment to clean up Cold War legacy sites, the U.S. Department of Energy (DOE) has initiated an exciting and unique project to dispose of its inventory of uranium-233 (233U) stored at Oak Ridge National Laboratory (ORNL), and extract isotopes that show great promise in the treatment of deadly cancers. In addition to increasing the supply of potentially useful medical isotopes, the project will rid DOE of a nuclear concern and cut surveillance and security costs. For more than 30 years, DOE's ORNL has stored over 1,200 containers of fissile 233U, originally produced for several defense-related projects, including a pilot study that looked at using 233U as a commercial reactor fuel. This uranium, designated as special nuclear material, requires expensive security, safety, and environmental controls. It has been stored at an ORNL facility, Building 3019A, that dates back to the Manhattan Project. Down-blending the material to a safer form, rather than continuing to store it, will eliminate a $15 million a year financial liability for the DOE and increase the supply of medical isotopes by 5,700 percent. During the down-blending process, thorium-229 (229Th) will be extracted. The thorium will then be used to extract actinium-225 (225Ac), which will ultimately supply its progeny, bismuth-213 (213Bi), for on-going cancer research. The research includes Phase II clinical trials for the treatment of acute myelogenous leukemia at Sloan-Kettering Memorial Cancer Center in New York, as well as other serious cancers of the lungs, pancreas, and kidneys using a technique known as alpha-particle radioimmunotherapy. Alpha-particle radioimmunotherapy is based on the emission of alpha particles by radionuclides. 213Bi is attached to a monoclonal antibody that targets specific cells. The bismuth then delivers a high-powered but short-range radiation dose, effectively killing the cancerous cells but sparing the surrounding tissue. Production of the actinium and

  2. TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

    Nicholas, R.G.; Lacy, N.H.; Butz, T.R.; Brandon, N.E.

    2004-10-06

    As part of its commitment to clean up Cold War legacy sites, the U.S. Department of Energy (DOE) has initiated an exciting and unique project to dispose of its inventory of uranium-233 (233U) stored at Oak Ridge National Laboratory (ORNL), and extract isotopes that show great promise in the treatment of deadly cancers. In addition to increasing the supply of potentially useful medical isotopes, the project will rid DOE of a nuclear concern and cut surveillance and security costs. For more than 30 years, DOE's ORNL has stored over 1,200 containers of fissile 233U, originally produced for several defense-related projects, including a pilot study that looked at using 233U as a commercial reactor fuel. This uranium, designated as special nuclear material, requires expensive security, safety, and environmental controls. It has been stored at an ORNL facility, Building 3019A, that dates back to the Manhattan Project. Down-blending the material to a safer form, rather than continuing to store it, will eliminate a $15 million a year financial liability for the DOE and increase the supply of medical isotopes by 5,700 percent. During the down-blending process, thorium-229 (229Th) will be extracted. The thorium will then be used to extract actinium-225 (225Ac), which will ultimately supply its progeny, bismuth-213 (213Bi), for on-going cancer research. The research includes Phase II clinical trials for the treatment of acute myelogenous leukemia at Sloan-Kettering Memorial Cancer Center in New York, as well as other serious cancers of the lungs, pancreas, and kidneys using a technique known as alpha-particle radioimmunotherapy. Alpha-particle radioimmunotherapy is based on the emission of alpha particles by radionuclides. 213Bi is attached to a monoclonal antibody that targets specific cells. The bismuth then delivers a high-powered but short-range radiation dose, effectively killing the cancerous cells but sparing the surrounding tissue. Production of the actinium and

  3. Removal of actinium from europium for the determination of specific radioactivity of ultra low-level Eu-152 in a sample exposed to atomic-bomb neutrons in Nagasaki

    Measurements of specific radioactivities of residual neutron-induced radionuclides such as 152Eu and 60Co have been carried out to check the validity of a series of computer calculations employed for the atomic-bomb neutron dosimetry in Hiroshima (exposed to uranium bomb) and Nagasaki (exposed to plutonium bomb). The use of these nuclides for atomic-bomb neutron dosimetry, however, has been limited by the following difficulties: (1) today, these radionuclides are found only at extremely low concentrations in materials exposed to the atomic-bomb and (2) the neutrons that induced these radionuclides were thermal and epithermal, while the neutron dose received in Hiroshima and Nagasaki is attributable to fast neutrons. In order to overcome the first difficulty, we established a chemical procedure to extract Eu and Co from materials exposed to the atomic-bomb, and the chemical procedure has been successful for the materials exposed to atomic-bomb within 1400 m in slant distance from the explosion point. As for Nagasaki, materials exposed in the distances farther than 1200 m have never been subjected to the measurement of residual neutron-induced radionuclides. In this work, determination of specific radioactivity of 152Eu (half-life: 13.542 y) in a sample exposed to Nagasaki atomic-bomb at a distant place from the explosion point was undertaken. But, because of radioactive decay during this ∝60 years since 1945 and long distance from the explosion point, the present specific radioactivity of 152Eu in the sample is extremely low (estimated to be ∝3 x 10-4 Bq-152Eu/mg-Eu), and a serious problem is interferences from daughters of 227Ac (half-life: 21.8 y) in the measurement of ultra low-level radioactivity of 152Eu. Hence, our chemical procedure to obtain Eu-enriched counting source should be improved, and much attention is being denoted to removal of Ac from Eu. (orig.)

  4. Tumor immunotargeting using innovative radionuclides.

    Kraeber-Bodéré, Françoise; Rousseau, Caroline; Bodet-Milin, Caroline; Mathieu, Cédric; Guérard, François; Frampas, Eric; Carlier, Thomas; Chouin, Nicolas; Haddad, Ferid; Chatal, Jean-François; Faivre-Chauvet, Alain; Chérel, Michel; Barbet, Jacques

    2015-01-01

    This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality. PMID:25679452

  5. Tumor Immunotargeting Using Innovative Radionuclides

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  6. A Critical Review of Alpha Radionuclide Therapy-How to Deal with Recoiling Daughters?

    de Kruijff, Robin M; Wolterbeek, Hubert T; Denkova, Antonia G

    2015-01-01

    This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET). Touching briefly on the clinical successes of radionuclides emitting only one alpha particle, the main focus of this article lies on those alpha-emitting radionuclides with multiple alpha-emitting daughters in their decay chain. While having the advantage of longer half-lives, the recoiled daughters of radionuclides like 224Ra (radium), 223Ra, and 225Ac (actinium) can do significant damage to healthy tissue when not retained at the tumour site. Three different approaches to deal with this problem are discussed: encapsulation in a nano-carrier, fast uptake of the alpha emitting radionuclides in tumour cells, and local administration. Each approach has been shown to have its advantages and disadvantages, but when larger activities need to be used clinically, nano-carriers appear to be the most promising solution for reducing toxic effects, provided there is no accumulation in healthy tissue. PMID:26066613

  7. A Critical Review of Alpha Radionuclide Therapy—How to Deal with Recoiling Daughters?

    de Kruijff, Robin M.; Wolterbeek, Hubert T.; Denkova, Antonia G.

    2015-01-01

    This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET). Touching briefly on the clinical successes of radionuclides emitting only one alpha particle, the main focus of this article lies on those alpha-emitting radionuclides with multiple alpha-emitting daughters in their decay chain. While having the advantage of longer half-lives, the recoiled daughters of radionuclides like 224Ra (radium), 223Ra, and 225Ac (actinium) can do significant damage to healthy tissue when not retained at the tumour site. Three different approaches to deal with this problem are discussed: encapsulation in a nano-carrier, fast uptake of the alpha emitting radionuclides in tumour cells, and local administration. Each approach has been shown to have its advantages and disadvantages, but when larger activities need to be used clinically, nano-carriers appear to be the most promising solution for reducing toxic effects, provided there is no accumulation in healthy tissue. PMID:26066613

  8. A Critical Review of Alpha Radionuclide Therapy—How to Deal with Recoiling Daughters?

    Robin M. de Kruijff

    2015-06-01

    Full Text Available This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET. Touching briefly on the clinical successes of radionuclides emitting only one alpha particle, the main focus of this article lies on those alpha-emitting radionuclides with multiple alpha-emitting daughters in their decay chain. While having the advantage of longer half-lives, the recoiled daughters of radionuclides like 224Ra (radium, 223Ra, and 225Ac (actinium can do significant damage to healthy tissue when not retained at the tumour site. Three different approaches to deal with this problem are discussed: encapsulation in a nano-carrier, fast uptake of the alpha emitting radionuclides in tumour cells, and local administration. Each approach has been shown to have its advantages and disadvantages, but when larger activities need to be used clinically, nano-carriers appear to be the most promising solution for reducing toxic effects, provided there is no accumulation in healthy tissue.

  9. Determining the Relative Age of Fault Activity through Analyses of Gouge Mineralogy and Geochemistry: A Case Study from V&#225;penn&#225; (Rychleby Mts), Czech Republic

    Pavel Hájek; Martin Stastny; Lucie Nováková

    2010-01-01

    The relative age of fractures can be determined through structural analyses in the field or through the detailed mineralogical (XRD) and chemical analyses (AAS method, volumetric, and gravimetric analysis) of fault gouge in the laboratory. The aim of this work was to compare these approaches. It was hypothesised that the two methods would yield consistent results. The studied faults were located in the Rychleby Mts, part of the Sudetic Marginal Fault Zone. The relative age of the faults was d...

  10. Imaging and treating tumor vasculature with targeted radiolabeled carbon nanotubes

    Alessandro Ruggiero

    2010-09-01

    imaging. Near-infrared three-dimensional fluorescent-mediated tomography was used to image the LS174T tumor model, collect antibody-alone PK data, and calculate the number of copies of VE-cad epitope per cell. All of these studies were performed as a single administration of construct and were found to be safe and well tolerated by the murine model. These data have implications that support further imaging and radiotherapy studies using a SWCNT-based platform and focusing on the tumor vessels as the target.Keywords: actinium-225 (225Ac, zirconium-89 (89Zr, angiogenesis, vascular endothelial-cadherin, radioimmunotherapy (RIT, radioimmunoPET

  11. A single VLSI chip for computing syndromes in the (225, 223) Reed-Solomon decoder

    Hsu, I. S.; Truong, T. K.; Shao, H. M.; Deutsch, L. J.

    1986-11-01

    A description of a single VLSI chip for computing syndromes in the (255, 223) Reed-Solomon decoder is presented. The architecture that leads to this single VLSI chip design makes use of the dual basis multiplication algorithm. The same architecture can be applied to design VLSI chips to compute various kinds of number theoretic transforms.

  12. 2 CFR Appendix C to Part 225 - State/Local-Wide Central Service Cost Allocation Plans

    2010-01-01

    ... service funds are dependent upon a reasonable level of working capital reserve to operate from one billing... operating purposes is considered reasonable. A working capital reserve exceeding 60 days may be approved by.... Working capital reserves 3. Carry-forward adjustments of allocated central service costs 4. Adjustments...

  13. 40 CFR 745.225 - Accreditation of training programs: target housing and child-occupied facilities.

    2010-07-01

    ... materials since its last application was approved that adversely affects the students ability to learn. (iv... accreditation to offer courses in any of the following disciplines: Inspector, risk assessor, supervisor... student and instructor manuals, or other materials to be used for each course. (B) A copy of the...

  14. 48 CFR 52.225-11 - Buy American Act-Construction Materials under Trade Agreements.

    2010-10-01

    ..., Poland, Portugal, Romania, Singapore, Slovak Republic, Slovenia, Spain, Sweden, Switzerland, Taiwan, or...); (3) A least developed country (Afghanistan, Angola, Bangladesh, Benin, Bhutan, Burkina Faso, Burundi..., Madagascar, Malawi, Maldives, Mali, Mauritania, Mozambique, Nepal, Niger, Rwanda, Samoa, Sao Tome...

  15. 48 CFR 252.225-7045 - Balance of Payments Program-Construction Material Under Trade Agreements.

    2010-10-01

    ..., Liechtenstein, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Romania, Singapore, Slovak... developed country (Afghanistan, Angola, Bangladesh, Benin, Bhutan, Burkina Faso, Burundi, Cambodia, Central..., Malawi, Maldives, Mali, Mauritania, Mozambique, Nepal, Niger, Rwanda, Samoa, Sao Tome and...

  16. 12 CFR 225.13 - Factors considered in acting on bank acquisition proposals.

    2010-01-01

    ... provided in § 211.24(c)(1)(ii) of the Board's Regulation K (12 CFR 211.24(c)(1)(ii)). (b) Other factors. In..., including the Board's Regulation BB (12 CFR part 228). (c) Interstate transactions. The Board may approve... future prospects, including whether current and projected capital positions and levels of...

  17. Biggest Pork Barrel Ever: $225-Million for Projects That Bypassed Merit Reviews.

    Cordes, Colleen

    1988-01-01

    Congress has quietly approved millions of dollars for campus research projects not subjected to traditional merit reviews. The wisdom of allowing legislators to direct federal money to specific campuses is questioned less and less, and the practice is more prevalent than ever. (MSE)

  18. 48 CFR 225.401-70 - End products subject to trade agreements.

    2010-10-01

    ... Materials handling equipment 40 Rope, cable, chain and fittings 41 Refrigeration and air conditioning equipment 42 Fire fighting, rescue and safety equipment 43 Pumps and compressors 44 Furnace, steam plant...

  19. 25 CFR 225.36 - Minerals agreement cancellation; Bureau of Indian Affairs notice of noncompliance.

    2010-04-01

    ... Indian Affairs, the orders may be appealed under 25 CFR part 2. If the orders are issued by the Secretary... 25 Indians 1 2010-04-01 2010-04-01 false Minerals agreement cancellation; Bureau of Indian Affairs... INTERIOR ENERGY AND MINERALS OIL AND GAS, GEOTHERMAL, AND SOLID MINERALS AGREEMENTS Minerals...

  20. 76 FR 66613 - Airworthiness Directives; Eurocopter France (Eurocopter) Model EC225LP Helicopters

    2011-10-27

    ... emergency regulation under DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979). If it is... detachment of the seat from the floor during an emergency landing. DATES: Effective November 14, 2011. The... could result in no longer retaining the seats in place in the event of an emergency or hard...

  1. 48 CFR 3052.225-70 - Requirement for Use of Certain Domestic Commodities.

    2010-10-01

    ... Certain Domestic Commodities. As prescribed in (HSAR) 48 CFR 3025.7003, use the following clause... CFR 2.101. (2) “Component” means any item supplied to the Government as part of an end product or of... forth in (FAR) 48 CFR 2.101. (5) “Qualifying country” means a country with a memorandum of...

  2. 7 CFR Appendix A to Part 225 - Alternate Foods for Meals

    2010-01-01

    ... alternate protein product and on an as prepared basis. f. For an alternate protein product mix... Used in the Summer Food Service Program? 1. An alternate protein product used in meals planned under... product whether used alone or in combination with meat or other meat alternates must meet the...

  3. Dark Matter Results from 225 Live Days of XENON100 Data

    Aprile, E; Arisaka, K; Arneodo, F; Balan, C; Baudis, L; Bauermeister, B; Behrens, A; Beltrame, P; Bokeloh, K; Brown, E; Bruno, G; Budnik, R; Cardoso, J M R; Chen, W -T; Choi, B; Cline, D; Colijn, A P; Contreras, H; Cussonneau, J P; Decowski, M P; Duchovni, E; Fattori, S; Ferella, A D; Fulgione, W; Gao, F; Garbini, M; Ghag, C; Giboni, K -L; Goetzke, L W; Grignon, C; Gross, E; Hampel, W; Kaether, F; Kettling, H; Kish, A; Lamblin, J; Landsman, H; Lang, R F; Calloch, M Le; Levy, C; Lim, K E; Lin, Q; Lindemann, S; Lindner, M; Lopes, J A M; Lung, K; Undagoitia, T Marrodan; Massoli, F V; Fernandez, A J Melgarejo; Meng, Y; Molinario, A; Nativ, E; Ni, K; Oberlack, U; Orrigo, S E A; Pantic, E; Persiani, R; Plante, G; Priel, N; Rizzo, A; Rosendahl, S; Santos, J M F dos; Sartorelli, G; Schreiner, J; Schumann, M; Lavina, L Scotto; Scovell, P R; Selvi, M; Shagin, P; Simgen, H; Teymourian, A; Thers, D; Vitells, O; Wang, H; Weber, M; Weinheimer, C

    2012-01-01

    We report on a search for particle dark matter with the XENON100 experiment, operated at the Laboratori Nazionali del Gran Sasso (LNGS) for 13 months during 2011 and 2012. XENON100 features an ultra-low electromagnetic background of (5.3\\pm0.6)\\times10^-3 events (kg day keVee)^-1 in the energy region of interest. A blind analysis of 224.6 live days \\times 34 kg exposure has yielded no evidence for dark matter interactions. The two candidate events observed in the pre-defined nuclear recoil energy range of 6.6-30.5 keVnr are consistent with the background expectation of (1.0 \\pm 0.2) events. A Profile Likelihood analysis using a 6.6-43.3 keVnr energy range sets the most stringent limit on the spin-independent elastic WIMP-nucleon scattering cross section for WIMP masses above 8 GeV/c^2, with a minimum of 2 \\times 10^-45 cm^2 at 55 GeV/c^2 and 90% confidence level.

  4. 12 CFR 225.200 - Conditions to Board's section 20 orders.

    2010-01-01

    ... “accredited investor” as defined in 17 CFR 230.501(a). (ii) Disclosures accompanying investment advice. A... Securities and Exchange Commission pursuant to 17 CFR 240.17a-11, a copy of the notice shall be filed... underwriting and dealing in bank-ineligible securities, 1 or order the bank holding company to divest...

  5. 40 CFR 795.225 - Dermal pharmacokinetics of DGBE and DGBA.

    2010-07-01

    ... rats shall be 7 to 8 weeks old and weigh 180 to 220 grams. Prior to testing, the animals shall be... as specified in the TSCA Good Laboratory Practice Standards, in part 792, subpart J of this chapter... and diethylene glycol butyl ether acetate (DGBA). (b) Test procedures—(1) Animal selection—(i)...

  6. 21 CFR 225.102 - Master record file and production records.

    2010-04-01

    ...(s) includes the complete history of a batch or production run. This record includes the amounts of... original production record or copy thereof shall be prepared by qualified personnel for each batch or run... production record shall describe the corrective action taken. (5) Each batch or production run of...

  7. 12 CFR 225.26 - Factors considered in acting on nonbanking proposals.

    2010-01-01

    ... unfair competition, conflicts of interest, and unsound banking practices). (b) Financial and managerial... financial and managerial resources of the notificant, including its subsidiaries and any company to be... effect of de novo proposals. Unless the record demonstrates otherwise, the commencement or expansion of...

  8. 2 CFR Appendix D to Part 225 - Public Assistance Cost Allocation Plans

    2010-01-01

    ... to Needy Families (TANF), Medicaid, Food Stamps, Child Support Enforcement, Adoption Assistance and... of its stewardship requirements, HHS has published requirements for the development, documentation, submission, negotiation, and approval of public assistance cost allocation plans in Subpart E of 45 CFR...

  9. 78 FR 55773 - Fourteenth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

    2013-09-11

    ... Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is issuing this notice to... Battery and Battery Systems--Small and Medium Size DATES: The meeting will be held October 1-3, 2013,...

  10. 12 CFR 225.101 - Bank holding company's subsidiary banks owning shares of nonbanking companies.

    2010-01-01

    ...) apply to the aggregate amount of stock held in a particular organization by the bank holding company... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Bank holding company's subsidiary banks owning... company's subsidiary banks owning shares of nonbanking companies. (a) The Board's opinion has...

  11. 49 CFR 40.225 - What form is used for an alcohol test?

    2010-10-01

    ... WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Testing Sites, Forms, Equipment and Supplies Used in Alcohol... foreign-language version of the ATF approved by ODAPC. You may use such a non-English language form only in a situation where both the employee and BAT/STT understand and can use the form in that language....

  12. 12 CFR 225.173 - How are investments in private equity funds treated under this subpart?

    2010-01-01

    ...) Portfolio companies held through a private equity fund. A financial holding company may not routinely manage... is controlled by a financial holding company may not routinely manage or operate a portfolio company... holding company. A private equity fund may routinely manage or operate a portfolio company so long as...

  13. 48 CFR 52.225-13 - Restrictions on Certain Foreign Purchases.

    2010-10-01

    ..., Executive order, or statute administered by OFAC, or if OFAC's implementing regulations at 31 CFR chapter V... Nationals and Blocked Persons at http://www.treas.gov/offices/enforcement/ofac/sdn More information about these restrictions, as well as updates, is available in the OFAC's regulations at 31 CFR chapter V...

  14. 28 CFR 54.225 - Educational institutions eligible to submit transition plans.

    2010-07-01

    ...) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE... section applies to each educational institution to which §§ 54.300 through 54.310 apply that: (1) Admitted... institution to which this section applies shall not discriminate on the basis of sex in admission...

  15. 14 CFR 1253.225 - Educational institutions eligible to submit transition plans.

    2010-01-01

    ... ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL...) Application. This section applies to each educational institution to which §§ 1253.300 through 1253.310 apply... educational institution to which this section applies shall not discriminate on the basis of sex in...

  16. Asmeri Keila-Joa maja hinnati 2,25 miljonile / Andris Feldmanis

    Feldmanis, Andris, 1982-

    2005-01-01

    Endise regionaalministri Toivo Asmeri abikaasa müüs talle kuuluva suvila Keila-Joal, T. Asmer ei avaldanud, mis hinnaga suvila oli ostetud, küll aga leidis ta, et tema abikaasale kuulunud suvila ei ole võrreldav Edgar Savisaare ostetud majaga

  17. Yeast Interacting Proteins Database: YHR114W, YGL225W [Yeast Interacting Proteins Database

    Full Text Available YHR114W BZZ1 SH3 domain protein implicated in the regulation of actin polymerization , able to re ... cruit actin polymerization ... machinery through its SH3 domains, colocalizes wit ... main protein implicated in the regulation of actin polymerization , able to recruit actin polymerization ... machinery th ...

  18. 20 CFR 225.34 - How the amount of the DRC is figured.

    2010-04-01

    ... figured. (a) The amount of the DRC depends on— (1) The year the employee reaches full retirement age; and... the employee is age 65 or older and for which credit is due. (4) Employee attains full retirement age... retirement age, the DRC percent will be as follows: Year employee attains full retirement age...

  19. A continuum damage analysis of hydrogen attack in 2.25 Cr-1Mo vessel

    van der Burg, M.W.D.; van der Giessen, E.; Tvergaard, Viggo

    1998-01-01

    A micromechanically based continuum damage model is presented to analyze the stress, temperature and hydrogen pressure dependent material degradation process termed hydrogen attack, inside a pressure vessel. Hydrogen attack (HA) is the damage process of grain boundary facets due to a chemical...... temperature, hydrogen pressure and applied stresses. The model is applied to study HA in a vessel wall, where nonuniform distributions of hydrogen pressure, temperature and stresses result in a nonuniform damage distribution over the vessel wall. Stresses inside the vessel wall first tend to accelerate and...... later decelerate the cavitation rate significantly. Numerical studies for different material parameters and different stress conditions demonstrate the HA process inside a vessel in time. Also, the lifetime of the pressure vessel is determined. The analyses underline that the general applicability of...

  20. SU-E-J-225: CEST Imaging in Head and Neck Cancer Patients

    Purpose: Chemical Exchange Saturation Transfer (CEST) imaging is an MRI technique enables the detection and imaging of metabolically active compounds in vivo. It has been used to differentiate tumor types and metabolic characteristics. Unlike PET/CT,CEST imaging does not use isotopes so it can be used on patient repeatedly. This study is to report the preliminary results of CEST imaging in Head and Neck cancer (HNC) patients. Methods: A CEST imaging sequence and the post-processing software was developed on a 3T clinical MRI scanner. Ten patients with Human papilloma virus positive oropharyngeal cancer were imaged in their immobilized treatment position. A 5 mm slice CEST image was acquired (128×128, FOV=20∼24cm) to encompass the maximum dimension of tumor. Twenty-nine off-set frequencies (from −7.8ppm to +7.8 ppm) were acquired to obtain the Z-spectrum. Asymmetry analysis was used to extract the CEST contrasts. ROI at the tumor, node and surrounding tissues were measured. Results: CEST images were successfully acquired and Zspectrum asymmetry analysis demonstrated clear CEST contrasts in tumor as well as the surrounding tissues. 3∼5% CEST contrast in the range of 1 to 4 ppm was noted in tumor as well as grossly involved nodes. Injection of glucose produced a marked increase of CEST contrast in tumor region (∼10%). Motion and pulsation artifacts tend to smear the CEST contrast, making the interpretation of the image contrast difficult. Field nonuniformity, pulsation in blood vesicle and susceptibility artifacts caused by air cavities were also problematic for CEST imaging. Conclusion: We have demonstrated successful CEST acquisition and Z-spectrum reconstruction on HNC patients with a clinical scanner. MRI acquisition in immobilized treatment position is critical for image quality as well as the success of CEST image acquisition. CEST images provide novel contrast of metabolites in HNC and present great potential in the pre- and post-treatment assessment of patients undergoing radiation therapy