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Sample records for actinium 225

  1. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  2. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces ∼100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 GeV protons

  3. New method for large scale production of medically applicable Actinium-225 and Radium-223

    Alpha-emitters (211At, 212Bi, 213Bi, 223Ra, 225Ac) are promising for targeted radiotherapy of cancer. Only two alpha decays near a cell membrane result in 50% death of cancer cell and only a single decay inside the cell is required for this. 225Ac may be used either directly or as a mother radionuclide in 213Bi isotope generator. Production of 225Ac is provided by three main suppliers - Institute for Transuranium Elements in Germany, Oak Ridge National Laboratory in USA and Institute of Physics and Power Engineering in Obninsk, Russia. The current worldwide production of 225Ac is approximately 1.7 Ci per year that corresponds to only 100-200 patients that could be treated annually. The common approach for 225Ac production is separation from mother 229Th or irradiation of 226Ra with protons in a cyclotron. Both the methods have some practical limitations to be applied routinely. 225Ac can be also produced by irradiation of natural thorium with medium energy protons . Cumulative cross sections of 225Ac, 227Ac, 227Th, 228Th formations have been obtained recently. Thorium targets (1-9 g) were irradiated by 114-91 MeV proton beam (1-50 μA) at INR linear accelerator. After dissolution in 8 M HNO3 + 0.004 M HF thorium was removed by double LLX by HDEHP in toluene (1:1). Ac and REE were pre-concentrated and separated from Ra and most fission products by DGA-Resin (Triskem). After washing out by 0.01 M HNO3 Ac was separated from REE by TRU Resin (Triskem) in 3 M HNO3 media. About 6 mCi 225Ac were separated in hot cell with chemical yield 85%. The method may be upscaled for production of Ci amounts of the radionuclide. The main impurity is 227Ac (0.1% at the EOB) but it does not hinder 225Ac from being used for medical 225Ac/213Bi generators. (author)

  4. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  5. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the

  6. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  7. Spectroscopic and computational investigation of actinium coordination chemistry.

    Ferrier, Maryline G; Batista, Enrique R; Berg, John M; Birnbaum, Eva R; Cross, Justin N; Engle, Jonathan W; La Pierre, Henry S; Kozimor, Stosh A; Lezama Pacheco, Juan S; Stein, Benjamin W; Stieber, S Chantal E; Wilson, Justin J

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, Ac(III) reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between Ac(III) and Am(III) in HCl solutions indicate Ac(III) coordinates more inner-sphere Cl(1-) ligands (3.2±1.1) than Am(III) (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique Ac(III) chemical behaviour. PMID:27531582

  8. Generator method of 225Ac production without a carrier for nuclear medicine

    The two-steps isotope generator scheme of 225Ac production from 229Th has been developed. The first step is used for separation of thorium, actinium, radium and daughter decay products (DDP), and removals of parent radionuclide. The second step provides additional separation of actinium from traces of radium and DDP, and conversion of actinium in the nitrate form. The chosen solutions provide optimal conditions for carry out of process. The yield of the 225Ac was 99.9% at minimal losses of parent 229Th (less than 0.1%)

  9. Extraction of actinium with di-(2-ethylhexyl)phosphoric acid from hydrochloric and nitric acid solutions

    The extraction of actinium with HDEHP from Cl- and NO3- systems has been investigated. It was found that extraction of actinium from HCl solutions is much better than from HNO3 solutions. Stability constants of actinium complexes Ac(X-)+2 with Cl- and NO3- ligands were determined. Our results show that the actinium formed less stable complexes with Cl- than with NO3- ligands. 5 refs., 3 figs., 1 tab. (author)

  10. The sorption of polonium, actinium and protactinium onto geological materials

    This paper describes a combined experimental and modeling program of generic sorption studies to increase confidence in the performance assessment for a potential high-level radioactive waste repository in Japan. The sorption of polonium, actinium and protactinium onto geological materials has been investigated. Sorption of these radioelements onto bentonite, tuff and granodiorite from equilibrated de-ionized water was studied under reducing conditions at room temperature. In addition, the sorption of actinium and protactinium was investigated at 60 C. Thermodynamic chemical modeling was carried out to aid interpretation of the results

  11. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    Fry, C; Thoennessen, M

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  12. Separation of Actinium 227 from the uranium minerals

    The purpose of this work was to separate Actinium 227, whose content is 18%, from the mineral carnotite found in Gomez Chihuahua mountain range in Mexico. The mineral before processing is is pre-concentrated and passed, first through anionic exchange resins, later the eluate obtained is passed through cationic resins. The resins were 20-50 MESH QOWEX and 100-200 MESH 50 X 8-20 in some cased 200-400 MESH AG 50W-X8, 1X8 in other cases. The eluates from the ionic exchange were electrodeposited on stainless steel polished disc cathode and platinum electrode as anode; under a current ODF 10mA for 2.5 to 5 hours and of 100mA for .5 of an hour. it was possible to identify the Actinium 227 by means of its descendents, TH-227 and RA-223, through alpha spectroscopy. Due to the radiochemical purity which the electro deposits were obtained the Actinium 227 was low and was not quantitatively determined. A large majority of the members of the natural radioactive series 3 were identified and even alpha energies reported in the literature with very low percentages of non-identified emissions were observed. We conclude that a more precise study is needed concerning ionic exchange and electrodeposit to obtain an Actinium 227 of radiochemical purity. (Author)

  13. Production of high-purity radium-223 from legacy actinium-beryllium neutron sources.

    Soderquist, Chuck Z; McNamara, Bruce K; Fisher, Darrell R

    2012-07-01

    Radium-223 is a short-lived alpha-particle-emitting radionuclide with potential applications in cancer treatment. Research to develop new radiopharmaceuticals employing (223)Ra has been hindered by poor availability due to the small quantities of parent actinium-227 available world-wide. The purpose of this study was to develop innovative and cost-effective methods to obtain high-purity (223)Ra from (227)Ac. We obtained (227)Ac from two surplus actinium-beryllium neutron generators. We retrieved the actinium/beryllium buttons from the sources and dissolved them in a sulfuric-nitric acid solution. A crude actinium solid was recovered from the solution by coprecipitation with thorium fluoride, leaving beryllium in solution. The crude actinium was purified to provide about 40 milligrams of actinium nitrate using anion exchange in methanol-water-nitric acid solution. The purified actinium was then used to generate high-purity (223)Ra. We extracted (223)Ra using anion exchange in a methanol-water-nitric acid solution. After the radium was separated, actinium and thorium were then eluted from the column and dried for interim storage. This single-pass separation produces high purity, carrier-free (223)Ra product, and does not disturb the (227)Ac/(227)Th equilibrium. A high purity, carrier-free (227)Th was also obtained from the actinium using a similar anion exchange in nitric acid. These methods enable efficient production of (223)Ra for research and new alpha-emitter radiopharmaceutical development. PMID:22697483

  14. BEH 225 Tutorials /beh225dotcom

    veena022

    2015-01-01

    BEH 225 Entire Course For more course tutorials visit www.beh225.com   BEH 225 Week 1 CheckPointResearch Methods BEH 225 Week 1 DQ 1 and DQ 2 BEH 225 Week 2 CheckPointHeredity and Hormones BEH 225 Week 2 AssignmentBrain Response of Behavior BEH 225 Week 3 CheckPointIntelligence Presentation BEH 225 Week 3 DQ 1 and DQ 2 BEH 225 Week 4 CheckPointSkinner Article BEH 225 Week 4 AssignmentProblem-Solving Simulation BEH 225 Week 5 CheckPointMotiv...

  15. Synthesis of chelating agents for actinium 225 complexation and its application in radioimmunotherapy

    Immunotherapy with radiolabeled antibodies should allow fairly specific targeting of certain cancers. However, iodine 131 may not be the best isotope for tumor therapy because of its limited specific activity, low beta-energy, relatively long half life and strong gamma emission. Another approach to improve therapeutic efficacy is the use of replacement isotopes with better physical properties. Chelator that can hold radio-metals with high stability under physiological conditions are essential to avoid excessive damage to non-target cells; Moreover, the development of new bifunctional chelating agents is essential for this purpose. Accordingly, our efforts have been directed, for several years, to the synthesis of original chelating agents likely to form stable complexes in vivo with the numerous potential candidates for such applications. Therefore, we have developed a new simple and efficient synthesis pathway of 2-(4-iso-thio-cyanate-benzyl)-1,4,7,10,13,16- hexa-aza-cyclo-hexadecane- 1,4,7,10,13,16-hexa-acetic acid, though functionalized on the cycle by a termination allowed coupling to an antibody or any other biological substance such as a hapten. (author)

  16. Radium, thorium, and actinium extraction from seawater using an improved manganese-oxide-coated fiber

    Laboratory experiments were conducted to determine the efficiency with which improved manganese-oxide-coated acrylic fibers extract radium, thorium, and actinium from seawater. Tests were made using surface seawater spiked with 227Ac, 227Th and 223Ra. For sample volumes of approximately 30 liters and flow rates up to 0.5 liters per minute, radium and actinium are removed quantitatively. Approximately 80-95% of the thorium is removed under these same conditions. (Auth.)

  17. ADJ 225 Courses Tutorial / indigohelp

    nesa

    2015-01-01

    ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ADJ 225 Assignment Risk Factor Handout ADJ 225 CheckPoint Community Agency Goals ADJ 225 CheckPoint 1 Juvenile Court Characteristics ADJ 2...

  18. ENG 225 ASH Course Tutorial / eng225dotcom

    anil27

    2015-01-01

    ENG 225 Entire Course (Ash) For more course tutorials visit www.eng225.com   ENG 225 Week 1 DQ 1 An Evolving Industry ENG 225 Week 1 DQ 2 Narrative and Storytelling ENG 225 Week 1 Quiz ENG 225 Week 2 DQ 1 Actors and Acting ENG 225 Week 2 DQ 2 Tools of Cinematography ENG 225 Week 2 Assignment Elements of Design ENG 225 Week 2 Quiz ENG 225 Week 3 DQ 1 Frame by Frame ENG 225 Week 3 DQ 2 Music and Soundscapes ENG 225 Week 3 Assignment Final Film Cri...

  19. ENG 225 ASH Material-eng225dotcom

    Sandywilliam1

    2015-01-01

    ENG 225 Entire Course (Ash) For more course tutorials visit www.eng225.com   ENG 225 Week 1 DQ 1 An Evolving Industry ENG 225 Week 1 DQ 2 Narrative and Storytelling ENG 225 Week 1 Quiz ENG 225 Week 2 DQ 1 Actors and Acting ENG 225 Week 2 DQ 2 Tools of Cinematography ENG 225 Week 2 Assignment Elements of Design ENG 225 Week 2 Quiz ENG 225 Week 3 DQ 1 Frame by Frame ENG 225 Week 3 DQ 2 Music and Soundscapes ENG 225 Week 3 Assignment Final Film Cri...

  20. ADJ 225 Course Tutorial / tutorialrank

    welcome1365

    2015-01-01

    ADJ 225 Entire Course For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 1 Times, Rating: A+     ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ...

  1. Neutron-Induced Fission of Actinium-227, Protactinium-231 and Neptunium-237: Mass Distribution

    Results of radiochemical studies on the mass distribution in the neutron-induced fission of actinium-227, protactinium-231 and neptunium-237 have been presented. This work has been carried out as part of a programme to determine the mass distribution in the fission of heavy elements as a function of Z and A. All irradiations have been carried out in the core of the swimming-pool type reactor APSARA with cadmium shielding wherever necessary. Relative yields of several fission product nuclides have been obtained by a method involving a comparison of the fission product activities from the respective targets with those formed from uranium-235 simultaneously irradiated. Thermal-neutron fission yields of uranium-235 have been assumed. These results indicate a predominantly asymmetric mass distribution in all the three cases, and also a distinct though small symmetric peak in the case of actinium-227. (author)

  2. A new method for the determination of low-level actinium-227 in geological samples

    We developed a new method for the determination of 227Ac in geological samples. The method uses extraction chromatographic techniques and alpha-spectrometry and is applicable for a range of natural matrices. Here we report on the procedure and results of the analysis of water (fresh and seawater) and rock samples. Water samples were acidified and rock samples underwent total dissolution via acid leaching. A DGA (N,N,N',N'-tetra-n-octyldiglycolamide) extraction chromatographic column was used for the separation of actinium. The actinium fraction was prepared for alpha spectrometric measurement via cerium fluoride micro-precipitation. Recoveries of actinium in water samples were 80 ± 8 % (number of analyses n = 14) and in rock samples 70 ± 12 % (n = 30). The minimum detectable activities (MDA) were 0.017-0.5 Bq kg-1 for both matrices. Rock sample 227Ac activities ranged from 0.17 to 8.3 Bq kg-1 and water sample activities ranged from below MDA values to 14 Bq kg-1of 227Ac. From the analysis of several standard rock and water samples with the method we found very good agreement between our results and certified values. (author)

  3. ADJ 225 Courses/snaptutorial

    charles

    2015-01-01

    ­For more classes visits www.snaptutorial.com                 ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ADJ ...

  4. BEH 225 Course tutorial/ indigohelp

    AcSCCSA

    2015-01-01

    For more classes visit www.indigohelp.com   BEH 225 Week 1 CheckPointResearch Methods BEH 225 Week 1 DQ 1 and DQ 2 BEH 225 Week 2 CheckPoint Heredity and Hormones BEH 225 Week 2 Assignment Brain Response of Behavior BEH 225 Week 3 CheckPoint Intelligence Presentation BEH 225 Week 3 DQ 1 and DQ 2 BEH 225 Week 4 CheckPoint Skinner Article BEH 225 Week 4 AssignmentProblem-Solving Simulation BEH 225 Week 5 CheckPoint Motivating Employees BEH 22...

  5. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    Momeni, M.H.

    1981-09-01

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore.

  6. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore

  7. ADJ 225 UOP COURSE Tutorial/UOPHELP

    mangush

    2015-01-01

    For more course tutorials visit www.uophelp.com       ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ADJ 225 Assignment Risk Factor Handout ADJ 225 CheckPoint...

  8. In-source laser spectroscopy developments at TRILIS—towards spectroscopy on actinium and scandium

    Resonance Ionization Laser Ion Sources (RILIS) have become a versatile tool for production and study of exotic nuclides at Isotope Separator On-Line (ISOL) facilities such as ISAC at TRIUMF. The recent development and addition of a grating tuned spectroscopy laser to the TRIUMF RILIS solid state laser system allows for wide range spectral scans to investigate atomic structures on short lived isotopes, e.g., those from the element actinium, produced in uranium targets at ISAC. In addition, development of new and improved laser ionization schemes for rare isotope production at ISAC is ongoing. Here spectroscopic studies on bound states, Rydberg states and autoionizing (AI) resonances on scandium using the existing off-line capabilities are reported. These results allowed to identify a suitable ionization scheme for scandium via excitation into an autoionizing state at 58,104 cm − 1 which has subsequently been used for ionization of on-line produced exotic scandium isotopes.

  9. ENG 225 UOP COURSE Tutorial/UOPHELP

    dfvgbnm,m

    2015-01-01

    For more course tutorials visit www.uophelp.com   ENG 225 Week 1 DQ 1 An Evolving Industry ENG 225 Week 1 DQ 2 Narrative and Storytelling ENG 225 Week 1 Quiz ENG 225 Week 2 DQ 1 Actors and Acting ENG 225 Week 2 DQ 2 Tools of Cinematography ENG 225 Week 2 Assignment Elements of Design ENG 225 Week 2 Quiz ENG 225 Week 3 DQ 1 Frame by Frame ENG 225 Week 3 DQ 2 Music and Soundscapes ENG 225 Week 3 Assignment Final Film Critique Draft ENG 225 Week 3 Q...

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    NARESH 1

    2015-01-01

    For more course tutorials visit www.tutorialoutlet.com     ENG 225 Week 1 DQ 1 An Evolving Industry ENG 225 Week 1 DQ 2 Narrative and Storytelling ENG 225 Week 1 Quiz ENG 225 Week 2 DQ 1 Actors and Acting ENG 225 Week 2 DQ 2 Tools of Cinematography ENG 225 Week 2 Assignment Elements of Design ENG 225 Week 2 Quiz ENG 225 Week 3 DQ 1 Frame by Frame ENG 225 Week 3 DQ 2 Music and Soundscapes ENG 225 Week 3 Assignment Final Film Critique Draft ...

  11. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Raeder, S.; Bastin, B.; Block, M.; Creemers, P.; Delahaye, P.; Ferrer, R.; Fléchard, X.; Franchoo, S.; Ghys, L.; Gaffney, L. P.; Granados, C.; Heinke, R.; Hijazi, L.; Huyse, M.; Kron, T.; Kudryavtsev, Yu.; Laatiaoui, M.; Lecesne, N.; Luton, F.; Moore, I. D.; Martinez, Y.; Mogilevskiy, E.; Naubereit, P.; Piot, J.; Rothe, S.; Savajols, H.; Sels, S.; Sonnenschein, V.; Traykov, E.; Van Beveren, C.; Van den Bergh, P.; Van Duppen, P.; Wendt, K.; Zadvornaya, A.

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  12. ADJ 225 UOP Course Tutorial / Tutorialrank

    charles

    2015-01-01

    For more course tutorials visit www.tutorialrank.com ADJ 225 Assignment Corrections Comparison Summary (UOP) ADJ 225 Assignment Final Project(UOP) ADJ 225 Assignment Juvenile Court Comparison(UOP) ADJ 225 CheckPoint Juvenile Offenders(UOP) ADJ 225 Assignment Risk Factor Handout(UOP) ADJ 225 CheckPoint 1 Juvenile Court Characteristics(UOP) ADJ 225 CheckPoint 2 Mission Statement(UOP) ADJ 225 CheckPoint Case Study Sequence(UOP) ADJ 225 CheckPoint Community Agency ...

  13. BEH 225 UOP course/uophelp

    uophelp

    2015-01-01

    For more course tutorials visit www.uophelp.com   BEH 225 Week 1 CheckPointResearch Methods BEH 225 Week 1 DQ 1 and DQ 2 BEH 225 Week 2 CheckPoint Heredity and Hormones BEH 225 Week 2 Assignment Brain Response of Behavior BEH 225 Week 3 CheckPoint Intelligence Presentation BEH 225 Week 3 DQ 1 and DQ 2 BEH 225 Week 4 CheckPoint Skinner Article BEH 225 Week 4 AssignmentProblem-Solving Simulation BEH 225 Week 5 CheckPoint Motivating Employees ...

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    sando

    2015-01-01

    For more course tutorials visit www.uophelp.com       ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ADJ 225 Assignment Risk Factor Handout ADJ 225 CheckPoint...

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    2015-01-01

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  16. 49 CFR 238.225 - Electrical system.

    2010-10-01

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    2010-01-01

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  18. 40 CFR 46.225 - Equipment.

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Equipment. 46.225 Section 46.225... After the Fellowship § 46.225 Equipment. (a) If EPA authorizes you to purchase equipment (see § 46.140(b)) and the equipment retains a fair market value of more than $5,000, you must request...

  19. 21 CFR 225.30 - Equipment.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Equipment. 225.30 Section 225.30 Food and Drugs... Equipment § 225.30 Equipment. (a) Equipment which is designed to perform its intended function and is properly installed and used is essential to the manufacture of medicated feeds. Such equipment...

  20. 21 CFR 225.130 - Equipment.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Equipment. 225.130 Section 225.130 Food and Drugs... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Facilities and Equipment § 225.130 Equipment. Equipment shall be capable of producing a medicated feed of intended potency and purity, and shall...

  1. 21 CFR 225.42 - Components.

    2010-04-01

    ... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Product Quality Control § 225.42 Components. (a) A... inventory control for all such drugs to aid in assuring their identity, strength, quality, and purity when... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Components. 225.42 Section 225.42 Food and...

  2. 49 CFR 397.225 - Judicial review.

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Judicial review. 397.225 Section 397.225... MATERIALS; DRIVING AND PARKING RULES Preemption Procedures § 397.225 Judicial review. A party to a proceeding under § 397.205(a), § 397.213(a), or § 397.223(a) may seek review by the appropriate...

  3. 22 CFR 225.102 - Definitions.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Definitions. 225.102 Section 225.102 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.102 Definitions. (a... example, a medical record). Private information must be individually identifiable (i.e., the identity...

  4. 21 CFR 225.10 - Personnel.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Personnel. 225.10 Section 225.10 Food and Drugs... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS General Provisions § 225.10 Personnel. (a) Qualified personnel and adequate personnel training and supervision are essential for the proper...

  5. 12 CFR 225.3 - Administration.

    2010-01-01

    ... Regarding Delegation of Authority (12 CFR part 265) and the Board's Rules of Procedure (12 CFR part 262). (b... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Administration. 225.3 Section 225.3 Banks and... COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations General Provisions § 225.3...

  6. ADJ 225 UOP Course Tutorial/TutorialRank

    apj

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 1 Times, Rating: A+   ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ADJ 225 Assignment Risk Factor Han...

  7. Octupole correlations in 225Th

    The nuclear structure of 225Th has been studied using the reaction 226Ra(α, 5n)225Th at a beam energy of 50 MeV. In-beam γγ, e-e-, e-n and e-γ coincidences have been measured, along with γ-ray and electron intensities, and these have been used to establish a decay scheme up to spin 39/2 ℎ and excitation energy 2494 keV. Parity doublets have been observed, forming two 'quasi-molecular bands', along with enhanced E1 transitions linking states of opposite parity. γ-branching ratios have been measured and an average value of vertical strokeD0/Q0vertical stroke=(0.51±0.06)x10-3 fm-1 has been deduced. The results are compared with calculations incorporating odd multipole degrees of freedom in the description of the nuclear shape. (orig.)

  8. DNA double strand breaks as predictor of efficacy of the alpha-particle emitter Ac-225 and the electron emitter Lu-177 for somatostatin receptor targeted radiotherapy.

    Franziska Graf

    Full Text Available RATIONALE: Key biologic effects of the alpha-particle emitter Actinium-225 in comparison to the beta-particle emitter Lutetium-177 labeled somatostatin-analogue DOTATOC in vitro and in vivo were studied to evaluate the significance of γH2AX-foci formation. METHODS: To determine the relative biological effectiveness (RBE between the two isotopes (as - biological consequence of different ionisation-densities along a particle-track, somatostatin expressing AR42J cells were incubated with Ac-225-DOTATOC and Lu-177-DOTATOC up to 48 h and viability was analyzed using the MTT assay. DNA double strand breaks (DSB were quantified by immunofluorescence staining of γH2AX-foci. Cell cycle was analyzed by flow cytometry. In vivo uptake of both radiolabeled somatostatin-analogues into subcutaneously growing AR42J tumors and the number of cells displaying γH2AX-foci were measured. Therapeutic efficacy was assayed by monitoring tumor growth after treatment with activities estimated from in vitro cytotoxicity. RESULTS: Ac-225-DOTATOC resulted in ED50 values of 14 kBq/ml after 48 h, whereas Lu-177-DOTATOC displayed ED50 values of 10 MBq/ml. The number of DSB grew with increasing concentration of Ac-225-DOTATOC and similarly with Lu-177-DOTATOC when applying a factor of 700-fold higher activity compared to Ac-225. Already 24 h after incubation with 2.5-10 kBq/ml, Ac-225-DOTATOC cell-cycle studies showed up to a 60% increase in the percentage of tumor cells in G2/M phase. After 72 h an apoptotic subG1 peak was also detectable. Tumor uptake for both radio peptides at 48 h was identical (7.5%ID/g, though the overall number of cells with γH2AX-foci was higher in tumors treated with 48 kBq Ac-225-DOTATOC compared to tumors treated with 30 MBq Lu-177-DOTATOC (35% vs. 21%. Tumors with a volume of 0.34 ml reached delayed exponential tumor growth after 25 days (44 kBq Ac-225-DOTATOC and after 21 days (34 MBq Lu-177-DOTATOC. CONCLUSION: γH2AX-foci formation, triggered

  9. Groundwater seepage from the Ranger uranium mine tailings dam: radioisotopes of radium, thorium and actinium. Supervising Scientist report 106

    Monitoring of bores near the Ranger uranium mine tailings dam has revealed deterioration in water quality in several bores since 1983. In a group of bores to the north of the dam, increases have been observed of up to 500 times for sulphate concentrations and of up to 5 times for 226Ra concentrations. Results are presented here of measurements of members of the uranium, thorium and actinium decay series in borewater samples collected between 1985 and 1993. In particular, measurements of all four naturally-occurring radium isotopes have been used in an investigation of the mechanism of radium concentration changes. For the most seepage-affected bores the major findings of the study include: 228Ra/226Ra 223Ra /226Ra and 224Ra/228Ra ratios all increased over the course of the study; barium concentrations show high seasonal variability, being lower in November than May, but strontium concentrations show a steady increase with time. Calculations show that the groundwater is probably saturated with respect to barite but not with respect to celestite or anglesite; sulphide concentrations are low in comparison with sulphate, and are higher in November than in May; and 227Ac concentrations have increased with time, but do not account for the high 223Ra/226Ra ratios. It is concluded on the basis of these observations that increases in Ra isotope concentrations observed in a number of seepage-affected bores arise from increases in salinity leading to desorption of radium from adsorption sites in the vicinity of the bore rather by direct transport of radium from the tailings. Increased salinity is also causing the observed increases in 227Ac and strontium concentrations, while formation of a barite solid phase in the groundwater is causing the removal of some radium from solution. This is the cause of the increasing radium isotope ratios noted above

  10. 24 CFR 990.225 - Transition determination.

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Transition determination. 990.225 Section 990.225 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT THE PUBLIC HOUSING OPERATING...

  11. 21 CFR 225.58 - Laboratory controls.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Laboratory controls. 225.58 Section 225.58 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Product Quality Control §...

  12. 12 CFR 225.177 - Definitions.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Definitions. 225.177 Section 225.177 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Merchant Banking Investments §...

  13. 25 CFR 225.2 - Information collection.

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Information collection. 225.2 Section 225.2 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS OIL AND GAS, GEOTHERMAL, AND... require review under the Paperwork Reduction Act (44 U.S.C. 3501 et seq.)....

  14. 48 CFR 225.503 - Group offers.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Group offers. 225.503... OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Evaluating Foreign Offers-Supply Contracts 225.503 Group offers. Evaluate group offers in accordance with FAR 25.503, but apply the...

  15. 48 CFR 225.104 - Nonavailable articles.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Nonavailable articles. 225.104 Section 225.104 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Nonavailable articles. (a) DoD has determined that the following articles also are nonavailable in...

  16. 40 CFR 86.225-94 - [Reserved

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false 86.225-94 Section 86.225-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty...

  17. 31 CFR 800.225 - United States.

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false United States. 800.225 Section 800... TAKEOVERS BY FOREIGN PERSONS Definitions § 800.225 United States. The term United States or U.S. means the United States of America, the States of the United States, the District of Columbia, and any...

  18. Dicty_cDB: SSI225 [Dicty_cDB

    Full Text Available SS (Link to library) SSI225 (Link to dictyBase) - - - Contig-U12571-1 SSI225E (Link... to Original site) - - - - - - SSI225E 293 Show SSI225 Library SS (Link to library) Clone ID SSI225 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSI2-B/SSI225Q.Seq.d/ Representative seq. ID SSI22...5E (Link to Original site) Representative DNA sequence >SSI225 (SSI225Q) /CSM/SS/SSI2-B/SSI225Q.Seq.d/ CTTTA...irkkk*e Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SSI225 (SSI

  19. Dicty_cDB: CHR225 [Dicty_cDB

    Full Text Available CH (Link to library) CHR225 (Link to dictyBase) - - - Contig-U11316-1 - (Link to Original site) - - CHR...225Z 621 - - - - Show CHR225 Library CH (Link to library) Clone ID CHR225 (Link to dicty...iol.tsukuba.ac.jp/CSM/CH/CHR2-B/CHR225Q.Seq.d/ Representative seq. ID - (Link to ...Original site) Representative DNA sequence >CHR225 (CHR225Q) /CSM/CH/CHR2-B/CHR225Q.Seq.d/ XXXXXXXXXXTTAGCTC... CSM-cDNA Score E Sequences producing significant alignments: (bits) Value CHR225 (CHR225Q) /CSM/CH/CHR2-B/CHR

  20. 21 CFR 225.115 - Complaint files.

    2010-04-01

    ... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Records and Reports § 225.115 Complaint files. (a... current good manufacturing practices. These complaints and experiences may reveal the existence of manufacturing problems not otherwise detected through the normal quality control procedures. Timely...

  1. 48 CFR 225.872-6 - Audit.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Audit. 225.872-6 Section...-6 Audit. (a) Memoranda of understanding with some qualifying countries contain annexes that provide for reciprocal “no-cost” audits of contracts and subcontracts (pre- and post-award). (b) To...

  2. 29 CFR 553.225 - Early relief.

    2010-07-01

    ... by the employer, the time involved must be added to the employee's tour of duty and treated as... Enforcement Employees of Public Agencies Tour of Duty and Compensable Hours of Work Rules § 553.225 Early... pursuant to employee agreement, either expressed or implied. This practice will not have the effect...

  3. 48 CFR 225.7501 - Policy.

    2010-10-01

    ... manufacturer or its supplier; (iv) An industrial gas; (v) A brand drug specified by the Defense Medical... low offer (see Subpart 225.5) is an offer of an end product that— (i) Is a qualifying country end product; (ii) Is an eligible product; or (iii) Is a nonqualifying country end product, but application...

  4. 21 CFR 225.80 - Labeling.

    2010-04-01

    ... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Packaging and Labeling § 225.80 Labeling. (a... adhered to, will assure that the article is safe and effective for its intended purposes. (b)(1) Labels... medicated feed and includes adequate information for the safe and effective use of the medicated feed....

  5. 48 CFR 225.7003-3 - Exceptions.

    2010-10-01

    ... requests to the Under Secretary of Defense (Acquisition, Technology, and Logistics) (USD(AT&L)) for a... qualifying country. (5) Specialty metal in any of the items listed in 225.7003-2 if the USD(AT&L), or an... domestic nonavailability determination), requires the approval of the USD(AT&L). (A) At least 30...

  6. 44 CFR 206.225 - Emergency work.

    2010-10-01

    ... HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE Public Assistance Eligibility § 206.225... economically eliminates the need for temporary housing. The work will be limited to that necessary for the... communications. Emergency communications necessary for the purpose of carrying out disaster relief functions...

  7. 21 CFR 137.225 - Whole durum flour.

    2010-04-01

    ... Flours and Related Products § 137.225 Whole durum flour. Whole durum wheat flour conforms to the..., prescribed for whole wheat flour by § 137.200, except that cleaned durum wheat, instead of cleaned wheat... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Whole durum flour. 137.225 Section 137.225...

  8. 14 CFR 13.225 - Offer of proof.

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Offer of proof. 13.225 Section 13.225... INVESTIGATIVE AND ENFORCEMENT PROCEDURES Rules of Practice in FAA Civil Penalty Actions § 13.225 Offer of proof. A party whose evidence has been excluded by a ruling of the administrative law judge may offer...

  9. 12 CFR 225.131 - Activities closely related to banking.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Activities closely related to banking. 225.131 Section 225.131 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... Holding Companies Interpretations § 225.131 Activities closely related to banking. (a) Bank...

  10. 12 CFR 225.123 - Activities closely related to banking.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Activities closely related to banking. 225.123 Section 225.123 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... Holding Companies Interpretations § 225.123 Activities closely related to banking. (a) Effective June...

  11. 12 CFR 225.129 - Activities closely related to banking.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Activities closely related to banking. 225.129 Section 225.129 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... Holding Companies Interpretations § 225.129 Activities closely related to banking. Courier activities....

  12. 25 CFR 225.26 - Auditing and accounting.

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Auditing and accounting. 225.26 Section 225.26 Indians... SOLID MINERALS AGREEMENTS Minerals Agreements § 225.26 Auditing and accounting. The Secretary may... agreement. Procedures and standards used for accounting and auditing of minerals agreements will be...

  13. 29 CFR 22.5 - Review by the reviewing official.

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Review by the reviewing official. 22.5 Section 22.5 Labor Office of the Secretary of Labor PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 22.5 Review by the reviewing official. (a) If, based on the report of the investigating official under § 22.4(b), the reviewing...

  14. Improved limit on the $^{225}$Ra electric dipole moment

    Bishof, Michael; Parker, Richard H.; Bailey, Kevin G.; Greene, John P.; Holt, Roy J.; Kalita, Mukut R.; Korsch, Wolfgang; Lemke, Nathan D.; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas P.; Singh, Jaideep T.; Dietrich, Matthew R.

    2016-01-01

    Background: Octupole-deformed nuclei, such as that of $^{225}$Ra, are expected to amplify observable atomic electric dipole moments (EDMs) that arise from time-reversal and parity-violating interactions in the nuclear medium. In 2015, we reported the first "proof-of-principle" measurement of the $^{225}$Ra atomic EDM. Purpose: This work reports on the first of several experimental upgrades to improve the statistical sensitivity of our $^{225}$Ra EDM measurements by orders of magnitude and eva...

  15. 14 CFR 121.225 - Propeller deicing fluid.

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Propeller deicing fluid. 121.225 Section 121.225 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS AND OPERATORS FOR COMPENSATION OR HIRE: CERTIFICATION AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND...

  16. 12 CFR 225.132 - Acquisition of assets.

    2010-01-01

    ... obtaining Board approval pursuant to section 4(c) (8) and the Board's Regulation Y (12 CFR 225.4(b)). (b) In... the Board's Regulation Y (12 CFR 225.4(c)(3)) generally prohibits a bank holding company or its... any merger “or acquisition of assets other than in the ordinary course of business” without...

  17. 40 CFR 225.4 - Waiver by Administrator.

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Waiver by Administrator. 225.4 Section... ENGINEERS DREDGED MATERIAL PERMITS § 225.4 Waiver by Administrator. The Administrator shall grant the... (including spawning and breeding areas), wildlife, or recreational areas. Notice of the Administrator's...

  18. 48 CFR 225.870-8 - Industrial security.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Industrial security. 225... Coordination 225.870-8 Industrial security. Industrial security for Canada shall be in accordance with the U.S.-Canada Industrial Security Agreement of March 31, 1952, as amended....

  19. 14 CFR 417.225 - Debris risk analysis.

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Debris risk analysis. 417.225 Section 417... OF TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.225 Debris risk analysis. A flight safety analysis must demonstrate that the risk to the public potentially exposed to inert...

  20. Dicty_cDB: CHB225 [Dicty_cDB

    Full Text Available CH (Link to library) CHB225 (Link to dictyBase) - - - Contig-U16517-1 CHB225P (Link to Original ... *edmqvqv*ekviy*elkiffhlqevl lnvvykvfqifilninhyymif*ivf *rtn*kkplihtyqqlnqerdhkm*lylwlvvsl mkrh*pftllil*ilv ...

  1. 21 CFR 225.1 - Current good manufacturing practice.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Current good manufacturing practice. 225.1 Section...) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS General Provisions § 225.1 Current good manufacturing practice. (a) Section 501(a)(2)(B) of the Federal Food, Drug, and Cosmetic...

  2. 48 CFR 252.225-7041 - Correspondence in English.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Correspondence in English... of Provisions And Clauses 252.225-7041 Correspondence in English. As prescribed in 225.1103(2), use the following clause: Correspondence in English (JUN 1997) The Contractor shall ensure that...

  3. 5 CFR 532.225 - Nonappropriated fund survey jobs.

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Nonappropriated fund survey jobs. 532.225... PREVAILING RATE SYSTEMS Prevailing Rate Determinations § 532.225 Nonappropriated fund survey jobs. (a) A lead agency shall survey the following required jobs: Job title Job grade Janitor (Light) 1 Food...

  4. 25 CFR 225.1 - Purpose and scope.

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Purpose and scope. 225.1 Section 225.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS OIL AND GAS, GEOTHERMAL, AND SOLID... Development Act of 1982, 25 U.S.C. 2101-2108 (IMDA). These regulations are applicable to the lands...

  5. 25 CFR 225.22 - Approval of minerals agreements.

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Approval of minerals agreements. 225.22 Section 225.22 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS OIL AND GAS, GEOTHERMAL... required, with section 102(2)(C) of the National Environmental Policy Act of 1969 (42 U.S.C. 4332(2)(C))...

  6. 7 CFR 1280.225 - Books and records of persons.

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Books and records of persons. 1280.225 Section 1280... PROMOTION, RESEARCH, AND INFORMATION ORDER Lamb Promotion, Research, and Information Order Reports, Books, and Records § 1280.225 Books and records of persons. (a) Each first handler, exporter of lambs,...

  7. 12 CFR 225.124 - Foreign bank holding companies.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Foreign bank holding companies. 225.124 Section... SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.124 Foreign bank holding companies. (a) Effective December 1, 1971,...

  8. 12 CFR 225.125 - Investment adviser activities.

    2010-01-01

    ... and that their securities are distributed to the public by such affiliated investment advisers, or... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Investment adviser activities. 225.125 Section... Companies Interpretations § 225.125 Investment adviser activities. (a) Effective February 1, 1972, the...

  9. 49 CFR 225.33 - Internal Control Plans.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Internal Control Plans. 225.33 Section 225.33....33 Internal Control Plans. (a) Each railroad shall adopt and comply with a written Internal Control... official business. Each railroad shall amend its Internal Control Plan, as necessary, to reflect...

  10. 22 CFR 225.112 - Review by institution.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Review by institution. 225.112 Section 225.112... institution. Research covered by this policy that has been approved by an IRB may be subject to further appropriate review and approval or disapproval by officials of the institution. However, those officials...

  11. 29 CFR 778.225 - Talent fees excludable under regulations.

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Talent fees excludable under regulations. 778.225 Section 778.225 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS OVERTIME COMPENSATION Payments That May Be Excluded From...

  12. Dicty_cDB: VFF225 [Dicty_cDB

    Full Text Available VF (Link to library) VFF225 (Link to dictyBase) - - - Contig-U15602-1 VFF225P (Link to Original ... B028630 |AB028630.1 Clostridium perfringens hyp27, bacH , ptp, cpd genes for hypothetical protein, bacteria ...

  13. 33 CFR 106.225 - Drill and exercise requirements.

    2010-07-01

    ...) Exercises are a full test of the Facility Security Plan and must include substantial and active.... 106.225 Section 106.225 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARINE SECURITY: OUTER CONTINENTAL SHELF (OCS) FACILITIES Outer Continental Shelf...

  14. 48 CFR 225.7403-2 - Contract clause.

    2010-10-01

    ..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Defense Contractors Outside the United States 225.7403-2 Contract clause. Use the clause at 252.225-7043, Antiterrorism/Force Protection Policy... performance or travel outside the United States, except for contracts with— (a) Foreign governments;...

  15. 48 CFR 225.7402-3 - Government support.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government support. 225... States 225.7402-3 Government support. (a) Government support that may be authorized or required for... coordination with the combatant commander that— (1) Such Government support is available and is needed...

  16. 48 CFR 52.225-5 - Trade Agreements.

    2010-10-01

    ... following: textiles and apparel articles; footwear, handbags, luggage, flat goods, work gloves, and leather... clause) Editorial Note: For Federal Register citations affecting § 52.225-5, see the List of CFR...

  17. 48 CFR 252.225-7037 - Evaluation of Offers for Air Circuit Breakers.

    2010-10-01

    ... Air Circuit Breakers. 252.225-7037 Section 252.225-7037 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.225-7037 Evaluation of Offers for Air Circuit Breakers. As prescribed in 225.7006-4(a), use the following provision: Evaluation of Offers for Air Circuit Breakers...

  18. 48 CFR 252.225-7031 - Secondary Arab boycott of Israel.

    2010-10-01

    ... Israel. 252.225-7031 Section 252.225-7031 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.225-7031 Secondary Arab boycott of Israel. As prescribed in 225.7605, use the following provision: Secondary Arab Boycott of Israel (JUN 2005) (a) Definitions. As used...

  19. 48 CFR 252.225-7008 - Restriction on Acquisition of Specialty Metals.

    2010-10-01

    ... of Specialty Metals. 252.225-7008 Section 252.225-7008 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.225-7008 Restriction on Acquisition of Specialty Metals. As prescribed in 225.7003-5(a)(1), use the following clause: Restriction on Acquisition of Specialty Metals...

  20. Encapsulation of α-Particle–Emitting 225Ac3+ Ions Within Carbon Nanotubes

    Matson, Michael L.; Villa, Carlos H.; Ananta, Jeyarama S.; Law, Justin J.; Scheinberg, David A.; Wilson, Lon J.

    2016-01-01

    225Ac3+ is a generator of α-particle–emitting radionuclides with 4 net α-particle decays that can be used therapeutically. Targeting 225Ac3+ by use of ligands conjugated to traditional bifunctional chelates limits the amount of 225Ac3+ that can be delivered. Ultrashort, single-walled carbon nanotubes (US-tubes), previously demonstrated as sequestering agents of trivalent lanthanide ions and small molecules, also successfully incorporate 225Ac3+. Methods Aqueous loading of both 225Ac3+ ions and Gd3+ ions via bath sonication was used to construct 225Ac@gadonanotubes (225Ac@GNTs). The 225Ac@GNTs were subsequently challenged with heat, time, and human serum. Results US-tubes internally loaded with both 225Ac3+ ions and Gd3+ ions show 2 distinct populations of 225Ac3+ ions: one rapidly lost in human serum and one that remains bound to the US-tubes despite additional challenge with heat, time, and serum. The presence of the latter population depended on cosequestration of Gd3+ and 225Ac3+ ions. Conclusion US-tubes successfully sequester 225Ac3+ ions in the presence of Gd3+ ions and retain them after a human serum challenge, rendering 225Ac@GNTs candidates for radioimmunotherapy for delivery of 225Ac3+ ions at higher concentrations than is currently possible for traditional ligand carriers. PMID:25931476

  1. 48 CFR 225.7702 - Acquisition of small arms.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition of small arms... Operations in Iraq or Afghanistan 225.7702 Acquisition of small arms. (a) Except as provided in paragraph (b) of this section, when acquiring small arms for assistance to the Army of Iraq, the Army...

  2. 20 CFR 637.225 - Determination of incentive bonus.

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of incentive bonus. 637.225... of incentive bonus. The amount of the incentive bonus to be paid to each State shall be the total of the incentive bonuses claimed for each eligible individual within the State. The amount of...

  3. 48 CFR 225.7304 - FMS customer involvement.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false FMS customer involvement... Military Sales 225.7304 FMS customer involvement. (a) FMS customers may request that a defense article or... contract without full and open competition. The FMS customer may also request that a subcontract be...

  4. 48 CFR 752.225-71 - Local procurement.

    2010-10-01

    ... and nationality waivers as set forth in subpart F of 22 CFR part 228 except as provided for in 22 CFR... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Local procurement. 752.225... Local procurement. For use in any USAID contract involving performance overseas. Local Procurement...

  5. Improved experimental limit on the EDM of 225Ra

    Bishof, Michael; Bailey, Kevin; Dietrich, Matthew R.; Greene, John P.; Holt, Roy J.; Kalita, Mukut R.; Korsch, Wolfgang; Lemke, Nathan D.; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Tom P.; Parker, Richard H.; Rabga, Tenzin; Singh, Jaideep T.

    2015-10-01

    Searches for permanent electric dipole moments (EDMs) in fundamental and composite particles are sensitive probes of beyond-standard-model symmetry violation that could explain the dominance of matter over anti-matter. The 225Ra (t1/2 = 15d, I = 1/2) atom is a particularly attractive system to use for an EDM measurement because its large nuclear octupole deformation, closely spaced ground-state parity doublet, and large atomic mass make 225Ra uniquely sensitive to symmetry-violating interactions in the nuclear medium. We have developed an experiment to measure the EDM of 225Ra and demonstrated the first ``proof-of-principle'' measurement, giving a 95% confidence upper limit of 5E-22 e-cm. After implementing a vacuum upgrade, we have observed nuclear spin coherence after 20 s of free evolution - a factor of ten improvement over our earlier results - and have lowered the 225Ra EDM limit by over an order of magnitude. Upcoming experimental upgrades have the potential to further improve our EDM sensitivity by many orders of magnitude, allowing us to test symmetry violation at an unprecedented level. This work is supported by U.S. DOE, Office of Science, Office of Nuclear Physics, under Contract DE-AC02-06CH11357.

  6. 40 CFR 98.225 - Procedures for estimating missing data.

    2010-07-01

    ... PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Nitric Acid Production § 98.225 Procedures for... (a) and (b) of this section. (a) For each missing value of nitric acid production, the substitute..., including emission factors, production rate, and N2O concentration, you must conduct a new performance...

  7. Expert Consideration on the Amendment to the INFCIRC/225

    The INFCIRC/225 has played an important role as a guideline for establishing international regimes for physical protection since it was published in 1975 by the IAEA. It has been amended four times to reflect the changes that have taken place with regard to nuclear security. The fourth revision was released in 1999. Since the release of this revision, the international nuclear security environment has changed drastically. Because of the September 11, 2001 terrorist attacks in the USA, an amendment to the CPPNM (Convention on Physical Protection of Nuclear Material) was passed at an international conference held in July of 2005 in Vienna. Many requests for a revision of the INFCIRC/225 have been raised since then. The IAEA had prepared a revised document; and sponsored the first of six meetings in order to amendment the document beginning in February of 2008. A TM (Technical Meeting) was also held in February of 2010. Physical protection experts from 22 countries participated in the meeting. After the TM, a draft document was sent to member states for reviewed for a designated 120 days. If ratified, document will then become the 5th amendment to the INFCIRC/225. The INFCIRC/225 will be used as a basis for physical protection measures specified in the Act. This paper will analyze the revised document and discussed on how it affects our national regime of physical protection

  8. 40 CFR 225.3 - Procedure for invoking economic impact.

    2010-07-01

    ... accordance with 33 CFR 209.120 and 209.145. (b) If the decision of the Chief of Engineers is that ocean... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Procedure for invoking economic impact... DUMPING CORPS OF ENGINEERS DREDGED MATERIAL PERMITS § 225.3 Procedure for invoking economic impact....

  9. 12 CFR 225.28 - List of permissible nonbanking activities.

    2010-01-01

    ... institutions—(i) Industrial banking. Owning, controlling, or operating an industrial bank, Morris Plan bank, or... Feasibility studies do not include assisting management with the planning or marketing for a given project or... itself. See also the Board's interpretation of bank management consulting advice (12 CFR 225.131). (1)...

  10. 7 CFR 225.6 - State agency responsibilities.

    2010-01-01

    ... meet the minimum requirements of 7 CFR 225.13. (b) Approval of sponsor applications. (1) Each State... Accounting Office at any reasonable time and place for a period of 3 years from the date of receipt of final... liability for payment of differences between the number of meals delivered by the food service...

  11. An irradiation facility at the 225 cm cyclotron in Stockholm

    An irradiation facility now in operation at the 225 cm cyclotron of the Research Institute for Physics in Stockholm is described. Irradiations are performed in an unfocused and otherwise lost part of the beam. The target can be inserted and extracted from the irradiation position without disturbing simultaneous in-beam measurements. (Auth.)

  12. Improved limit on the $^{225}$Ra electric dipole moment

    Bishof, Michael; Bailey, Kevin G; Greene, John P; Holt, Roy J; Kalita, Mukut R; Korsch, Wolfgang; Lemke, Nathan D; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas P; Singh, Jaideep T; Dietrich, Matthew R

    2016-01-01

    Background: Octupole-deformed nuclei, such as that of $^{225}$Ra, are expected to amplify observable atomic electric dipole moments (EDMs) that arise from time-reversal and parity-violating interactions in the nuclear medium. In 2015, we reported the first "proof-of-principle" measurement of the $^{225}$Ra atomic EDM. Purpose: This work reports on the first of several experimental upgrades to improve the statistical sensitivity of our $^{225}$Ra EDM measurements by orders of magnitude and evaluates systematic effects that contribute to current and future levels of experimental sensitivity. Method: Laser-cooled and trapped $^{225}$Ra atoms are held between two high voltage electrodes in an ultra high vacuum chamber at the center of a magnetically shielded environment. We observe Larmor precession in a uniform magnetic field using nuclear-spin-dependent laser light scattering and look for a phase shift proportional to the applied electric field, which indicates the existence of an EDM. The main improvement to o...

  13. 40 CFR 1065.225 - Intake-air flow meter.

    2010-07-01

    ... § 1065.205. This may include a laminar flow element, an ultrasonic flow meter, a subsonic venturi, a... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Intake-air flow meter. 1065.225... flow meter. (a) Application. You may use an intake-air flow meter in combination with a...

  14. 27 CFR 28.225 - Removals of beer by brewer.

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Removals of beer by brewer..., DEPARTMENT OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Exportation of Beer With Benefit of Drawback Execution of Claims § 28.225 Removals of beer by brewer. Where a brewer removes taxpaid beer from...

  15. 33 CFR 183.225 - Flotation test for persons capacity.

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Flotation test for persons... SECURITY (CONTINUED) BOATING SAFETY BOATS AND ASSOCIATED EQUIPMENT Flotation Requirements for Outboard Boats Rated for Engines of More Than 2 Horsepower Tests § 183.225 Flotation test for persons...

  16. 40 CFR 180.225 - Phosphine; tolerances for residues.

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Phosphine; tolerances for residues...) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.225 Phosphine; tolerances for residues. (a) General. (1) Tolerances are established for...

  17. 48 CFR 225.7703 - Acquisition of products or services other than small arms.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition of products or services other than small arms. 225.7703 Section 225.7703 Federal Acquisition Regulations System DEFENSE... than small arms....

  18. 48 CFR 225.7009 - Restriction on ball and roller bearings.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on ball and roller bearings. 225.7009 Section 225.7009 Federal Acquisition Regulations System DEFENSE ACQUISITION... roller bearings....

  19. 48 CFR 225.7003 - Restrictions on acquisition of specialty metals.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restrictions on acquisition of specialty metals. 225.7003 Section 225.7003 Federal Acquisition Regulations System DEFENSE... Restrictions on acquisition of specialty metals....

  20. Improved limit on the 225Ra electric dipole moment

    Bishof, Michael; Parker, Richard H.; Bailey, Kevin G.; Greene, John P.; Holt, Roy J.; Kalita, Mukut R.; Korsch, Wolfgang; Lemke, Nathan D.; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas P.; Singh, Jaideep T.; Dietrich, Matthew R.

    2016-08-01

    Background: Octupole-deformed nuclei, such as that of 225Ra, are expected to amplify observable atomic electric dipole moments (EDMs) that arise from time-reversal and parity-violating interactions in the nuclear medium. In 2015 we reported the first "proof-of-principle" measurement of the 225Ra atomic EDM. Purpose: This work reports on the first of several experimental upgrades to improve the statistical sensitivity of our 225Ra EDM measurements by orders of magnitude and evaluates systematic effects that contribute to current and future levels of experimental sensitivity. Method: Laser-cooled and trapped 225Ra atoms are held between two high-voltage electrodes in an ultrahigh-vacuum chamber at the center of a magnetically-shielded environment. We observe Larmor precession in a uniform magnetic field using nuclear-spin-dependent laser light scattering and look for a phase shift proportional to the applied electric field, which indicates the existence of an EDM. The main improvement to our measurement technique is an order-of-magnitude increase in spin-precession time, which is enabled by an improved vacuum system and a reduction in trap-induced heating. Results: We have measured the 225Ra atomic EDM to be less than 1.4 ×10-23e cm (95 % confidence upper limit), which is a factor of 36 improvement over our previous result. Conclusions: Our evaluation of systematic effects shows that this measurement is completely limited by statistical uncertainty. Combining this measurement technique with planned experimental upgrades, we project a statistical sensitivity at the 1 ×10-28e cm level and a total systematic uncertainty at the 4 ×10-29e cm level.

  1. 48 CFR 252.225-7010 - Commercial Derivative Military Article-Specialty Metals Compliance Certificate.

    2010-10-01

    ... Military Article-Specialty Metals Compliance Certificate. 252.225-7010 Section 252.225-7010 Federal... Military Article—Specialty Metals Compliance Certificate. As prescribed in 225.7003-5(b), use the following provision: Commercial Derivative Military Article—Specialty Metals Compliance Certificate (JUL 2009)...

  2. 48 CFR 225.871 - North Atlantic Treaty Organization (NATO) cooperative projects.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false North Atlantic Treaty Organization (NATO) cooperative projects. 225.871 Section 225.871 Federal Acquisition Regulations System... Other International Agreements and Coordination 225.871 North Atlantic Treaty Organization...

  3. Nuclear Structure Effects in the Exotic Decay of $^{225}$Ac via $^{14}$C Emission

    2002-01-01

    % IS323 \\\\ \\\\ We propose to build at Isolde a high intensity $^{225}$Ac source by $\\beta$-decay of $^{225}$(Ra+Fr) beam, to be used at the superconducting spectrometer SOLENO of IPN-Orsay in order to study a possible fine structure in the spectrum of $^{14}$C ions spontaneously emitted by $^{225}$Ac.

  4. 22 CFR 225.119 - Research undertaken without the intention of involving human subjects.

    2010-04-01

    ... involving human subjects. 225.119 Section 225.119 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.119 Research undertaken without the intention of involving human subjects. In the event research is undertaken without the intention of involving human subjects, but it...

  5. 22 CFR 225.118 - Applications and proposals lacking definite plans for involvement of human subjects.

    2010-04-01

    ... plans for involvement of human subjects. 225.118 Section 225.118 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.118 Applications and proposals lacking definite plans for involvement of human subjects. Certain types of applications for grants,...

  6. 48 CFR 252.225-7038 - Restriction on Acquisition of Air Circuit Breakers.

    2010-10-01

    ... of Air Circuit Breakers. 252.225-7038 Section 252.225-7038 Federal Acquisition Regulations System... Circuit Breakers. As prescribed in 225.7006-4(b), use the following clause: Restriction on Acquisition of Air Circuit Breakers (JUN 2005) Unless otherwise specified in its offer, the Contractor shall...

  7. 48 CFR 225.873 - Waiver of United Kingdom commercial exploitation levies.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Waiver of United Kingdom commercial exploitation levies. 225.873 Section 225.873 Federal Acquisition Regulations System DEFENSE... International Agreements and Coordination 225.873 Waiver of United Kingdom commercial exploitation levies....

  8. 48 CFR 52.225-14 - Inconsistency between English Version and Translation of Contract.

    2010-10-01

    ... English Version and Translation of Contract. 52.225-14 Section 52.225-14 Federal Acquisition Regulations... CLAUSES Text of Provisions and Clauses 52.225-14 Inconsistency between English Version and Translation of Contract. As prescribed in 25.1103(b), insert the following clause: Inconsistency Between English...

  9. 41 CFR 102-36.225 - Must we report excess related personal property?

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Must we report excess related personal property? 102-36.225 Section 102-36.225 Public Contracts and Property Management Federal... Property § 102-36.225 Must we report excess related personal property? Yes, you must report excess...

  10. 48 CFR 252.225-7030 - Restriction on Acquisition of Carbon, Alloy, and Armor Steel Plate.

    2010-10-01

    ... of Carbon, Alloy, and Armor Steel Plate. 252.225-7030 Section 252.225-7030 Federal Acquisition... Acquisition of Carbon, Alloy, and Armor Steel Plate. As prescribed in 225.7011-3, use the following clause: Restriction on Acquisition of Carbon, Alloy, and Armor Steel Plate (DEC 2006) (a) Carbon, alloy, and...

  11. 12 CFR 225.174 - What aggregate thresholds apply to merchant banking investments?

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What aggregate thresholds apply to merchant banking investments? 225.174 Section 225.174 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF...) Regulations Merchant Banking Investments § 225.174 What aggregate thresholds apply to merchant...

  12. 12 CFR 225.172 - What are the holding periods permitted for merchant banking investments?

    2010-01-01

    ... applicable under the Board's capital adequacy rules or guidelines (see 12 CFR 225 appendix A) to merchant... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What are the holding periods permitted for merchant banking investments? 225.172 Section 225.172 Banks and Banking FEDERAL RESERVE SYSTEM...

  13. 12 CFR 225.126 - Activities not closely related to banking.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Activities not closely related to banking. 225.126 Section 225.126 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE... Financial Holding Companies Interpretations § 225.126 Activities not closely related to banking. Pursuant...

  14. 48 CFR 252.225-7016 - Restriction on acquisition of ball and roller bearings.

    2010-10-01

    ... of ball and roller bearings. 252.225-7016 Section 252.225-7016 Federal Acquisition Regulations System... and roller bearings. As prescribed in 225.7009-5, use the following clause: Restriction on Acquisition of Ball and Roller Bearings (MAR 2006) (a) Definitions. As used in this clause' (1)...

  15. 27 CFR 25.225 - Destruction of taxpaid beer which was never removed from brewery premises.

    2010-04-01

    ... beer which was never removed from brewery premises. 25.225 Section 25.225 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Voluntary Destruction § 25.225 Destruction of taxpaid beer which was never removed from brewery premises. (a) General....

  16. 48 CFR 225.403 - World Trade Organization Government Procurement Agreement and Free Trade Agreements.

    2010-10-01

    ... Government Procurement Agreement and Free Trade Agreements. 225.403 Section 225.403 Federal Acquisition... FOREIGN ACQUISITION Trade Agreements 225.403 World Trade Organization Government Procurement Agreement and Free Trade Agreements. (c) For acquisitions of supplies covered by the World Trade...

  17. First Measurement of the Atomic Electric Dipole Moment of $^{225}$Ra

    Parker, R H; Kalita, M R; Lemke, N D; Bailey, K G; Bishof, M N; Greene, J P; Holt, R J; Korsch, W; Lu, Z -T; Mueller, P; O'Connor, T P; Singh, J T

    2015-01-01

    The radioactive radium-225 ($^{225}$Ra) atom is a favorable case to search for a permanent electric dipole moment (EDM). Due to its strong nuclear octupole deformation and large atomic mass, $^{225}$Ra is particularly sensitive to interactions in the nuclear medium that violate both time-reversal symmetry and parity. We have developed a cold-atom technique to study the spin precession of $^{225}$Ra atoms held in an optical dipole trap, and demonstrated the principle of this method by completing the first measurement of its atomic EDM, reaching an upper limit of $|$$d$($^{225}$Ra)$|$ $<$ $5.0\\!\\times\\!10^{-22}$ $e \\cdot$cm (95$\\%$ confidence).

  18. Muoproduction of neutral strange hadrons at 225 GeV

    The production of K/sub s/ 0, Λ0, and Lambda-bar0 has been measured in deep-inelastic muon scattering at 225 GeV; decays into two charged hadrons were detected. Momentum distributions are compared to the inclusive charged-hadron distributions measured in the same experiment. The range of virtual-photon parameters covered is 0.422 and 20<ν<210 GeV

  19. An improved limit on the EDM of 225 Ra

    Bishof, Michael; Bailey, Kevin; Dietrich, Matthew R.; Greene, John P.; Holt, Roy J.; Kalita, Mukut R.; Korsch, Wolfgang; Lemke, Nathan D.; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas P.; Parker, Richard H.; Rabga, Tenzin; Singh, Jaideep T.

    2016-05-01

    Searches for permanent electric dipole moments (EDMs) are sensitive probes of symmetry violation that could explain the dominance of matter over anti-matter. The 225 Ra (t1/2 = 15 days, I = 1/2) atom is a particularly attractive system to use for an EDM measurement because its octupole-deformed nucleus, closely spaced ground-state parity doublet, and large nuclear charge make 225 Ra uniquely sensitive to symmetry-violating interactions in the nuclear medium. In 2015, we reported the first ``proof of principle'' measurement of the 225 Ra EDM, giving a 95% confidence upper limit of 5* 10-22 e-cm; representing the first EDM measurement using laser-trapped atoms as well as the first EDM measurement of an atom with an octupole-deformed nucleus. After implementing upgrades to our apparatus, we now observe nuclear spin coherence after 20 s of free evolution - a factor of ten improvement. A new EDM measurement based on the upgraded system improved the 95% confidence upper limit by a factor of 36. We also report on the progress of current experimental upgrades that have the potential to further improve our EDM sensitivity by many orders of magnitude, allowing us to test symmetry violation at an unprecedented level. This work is supported by U.S. DOE, Office of Science, Office of Nuclear Physics, under Contract DE-AC02-06CH11357.

  20. Search for a Permanent Electric Dipole Moment of 225Ra

    Kalita, Mukut Ranjan

    The observation of a permanent electric dipole moment (EDM) in a non-degenerate system would indicate the violation of discrete symmetries of Time reversal (T) or combined application of Charge (C) and Parity (P) symmetry violation through the CPT theorem. The diamagnetic 225Ra atom with nuclear spin I=1/2 is a favorable candidate for an EDM search. Experimental sensitivity to its EDM is enhanced due to its high atomic mass and the increased Schiff moment of its octupole deformed nucleus. An experimental setup is developed where laser cooled neutral radium atoms are collected in a magneto-optical trap (MOT). The collected atoms are transported 1 meter with a far off-resonant optical dipole trap (ODT) and then the atoms are transferred to a second standing-wave ODT in an experimental chamber. The atoms are then optically polarized and allowed to Larmor precess in parallel and antiparallel electric and magnetic fields. The difference between the Larmor precession frequency for parallel and antiparallel fields is experimentally determined to measure the EDM. This thesis is about the first measurement of the EDM of the 225Ra atom where an upper limit of |d(225Ra)| EDM, CP violation, laser cooling and trapping, rare isotopes, radium.

  1. Effect of niobium on the embrittlement of 2.25 Cr and 2.25 Cr-1Mo steels by phosphous

    The influence of niobium on the temper embrittlement of 2.25Cr and 2.25 Cr-1Mo steels doped with phosphorus is evaluated. The transition temperatures of the samples tempered at 6500C and aged at different temperatures for niobium steels. (M.J.C.)

  2. NIR photometry of the flaring Quasar PKS050-225

    Carrasco, L.; Recillas, E.; Escobedo, G.; Carraminana, D. Y. Mayya. A.

    2012-11-01

    Following the report of a Gamma Ray flare in this object by M. Dutka et al. (Atel # 4574), we observed a recent NIR brightening of the high redshift, PKS0250-225 also known as CGRaBSJ0252-2219 z=1.419), cross identified with the gamma ray source 2FGLJ0252.7-2218. On November 24th 2012 (JD 2456255.7662), we determined the following photometric values H = 15.592+/- 0.05, J = 16.570 +/- 0.04 and Ks = 14.653 +/- 0.06.

  3. Combined effects of C225 and 125-iodine seed radiation on colorectal cancer cells

    To characterize the effect of combined treatment of the anti-epidermal growth factor receptor (EGFR) monoclonal antibody C225 and 125-iodine (125I) seed radiation in human colorectal cancer. We treated LS180 cells with 125I continuous low dose rate radiation in the presence and absence of 100 nM C225. The clonogenic capacity, cellular proliferation, cell cycle distribution, apoptosis, and molecular pathways of the cells following the treatments were analyzed in vitro. The sensitizer enhancement ratio of C225 was approximately 1.4. Treatment with C225 and radiation alone produced significant inhibition of cell growth, but combination therapy produced greater inhibition than either treatment administered alone. C225 increased the radiation-induced apoptosis and the fraction of γ-H2AX foci positive cells at 48 h after treatment. The Akt phosphorylation level was lower in the cells receiving the combination treatment than in the cells treated with radiation or C225 alone. These findings indicate that C225 sensitizes LS180 cells to 125I seed radiation. Growth inhibition is mediated by inducing apoptosis and not cell cycle arrest. Additionally, we confirmed that C225 impairs DNA repair by reducing the cellular level of the DNA-PKcs and Ku70 proteins. Furthermore, the inhibition of Akt signaling activation may be responsible for the C225-mediated radiosensitization

  4. 76 FR 54527 - Fourth Meeting: RTCA Special Committee 225: Rechargeable Lithium Batteries and Battery Systems...

    2011-09-01

    ... and Battery Systems--Small and Medium Sizes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 225 meeting: Rechargeable Lithium Batteries and Battery Systems--Small... Special Committee 225: Rechargeable Lithium Batteries and Battery Systems--Small and Medium Sizes....

  5. 76 FR 38741 - Third Meeting: RTCA Special Committee 225: Rechargeable Lithium Batteries and Battery Systems...

    2011-07-01

    ... and Battery Systems--Small and Medium Sizes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 225 meeting: Rechargeable Lithium Batteries and Battery Systems--Small... Special Committee 225: Rechargeable Lithium Batteries and Battery Systems--Small and Medium Sizes....

  6. 76 FR 6180 - First Meeting: RTCA Special Committee 225: Rechargeable Lithium Batteries and Battery Systems...

    2011-02-03

    ... and Battery Systems--Small and Medium Sizes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 225 meeting: Rechargeable Lithium Batteries and Battery Systems--Small... Special Committee 225: Rechargeable Lithium Batteries and Battery Systems--Small and Medium Sizes....

  7. 76 FR 22161 - Second Meeting: RTCA Special Committee 225: Rechargeable Lithium Batteries and Battery Systems...

    2011-04-20

    ... and Battery Systems--Small and Medium Sizes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 225 meeting: Rechargeable Lithium Batteries and Battery Systems--Small... Special Committee 225: Rechargeable Lithium Batteries and Battery Systems--Small and Medium Sizes....

  8. 48 CFR 225.7006 - Restriction on air circuit breakers for naval vessels.

    2010-10-01

    ... on air circuit breakers for naval vessels. ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on air circuit breakers for naval vessels. 225.7006 Section 225.7006 Federal Acquisition Regulations System...

  9. 12 CFR 225.102 - Bank holding company indirectly owning nonbanking company through subsidiaries.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Bank holding company indirectly owning nonbanking company through subsidiaries. 225.102 Section 225.102 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN...

  10. 20 CFR 225.33 - Months for which DRC's are due.

    2010-04-01

    ... Section 225.33 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT PRIMARY INSURANCE AMOUNT DETERMINATIONS Delayed Retirement Credits § 225.33 Months for which DRC's are due. (a) A DRC is due for each month after 1970 in which the employee is— (1) Full retirement age or...

  11. 7 CFR Appendix C to Part 225 - Child Nutrition (CN) Labeling Program

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Child Nutrition (CN) Labeling Program C Appendix C to... Appendix C to Part 225—Child Nutrition (CN) Labeling Program 1. The Child Nutrition (CN) Labeling Program... 7 CFR 210.10, 225.16, and 226.20 and are served in the main dish. (b) Juice drinks and juice...

  12. 48 CFR 252.225-7032 - Waiver of United Kingdom Levies-Evaluation of offers.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Waiver of United Kingdom... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7032 Waiver of United Kingdom Levies—Evaluation of offers. As prescribed in 225.1101(8), use the following provision: Waiver of United...

  13. 48 CFR 252.225-7033 - Waiver of United Kingdom levies.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Waiver of United Kingdom... of Provisions And Clauses 252.225-7033 Waiver of United Kingdom levies. As prescribed in 225.1101(9), use the following clause: Waiver of United Kingdom Levies (APR 2003) (a) The U.S. Government...

  14. 48 CFR 225.7011 - Restriction on carbon, alloy, and armor steel plate.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on carbon, alloy, and armor steel plate. 225.7011 Section 225.7011 Federal Acquisition Regulations System DEFENSE... on carbon, alloy, and armor steel plate....

  15. 42 CFR 22.5 - Leave without pay while on detail.

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Leave without pay while on detail. 22.5 Section 22... OTHER THAN COMMISSIONED OFFICERS Special Consultants § 22.5 Leave without pay while on detail. The... the period of a detail to a State, a subdivision thereof, or a private non-profit institution and...

  16. 12 CFR Appendix F to Part 225 - Interagency Guidelines Establishing Information Security Standards

    2010-01-01

    ... (FDIC); and 12 CFR part 570, app. B (OTS). The “Interagency Guidelines Establishing Information Security.... 225, App. F Appendix F to Part 225—Interagency Guidelines Establishing Information Security Standards.... Standards for Safeguarding Customer Information A. Information Security Program B. Objectives...

  17. 48 CFR 652.225-70 - Arab League Boycott of Israel.

    2010-10-01

    ... Israel. 652.225-70 Section 652.225-70 Federal Acquisition Regulations System DEPARTMENT OF STATE CLAUSES... League Boycott of Israel. As prescribed in 625.7002(a), insert the following provision: Arab League Boycott of Israel (AUG 1999) (a) Definitions. As used in this provision: Foreign person means any...

  18. 40 CFR 80.225 - What is the definition of a small refiner?

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false What is the definition of a small refiner? 80.225 Section 80.225 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... company and subsidiaries of the parent company, and any joint venture partners. A subsidiary under...

  19. 46 CFR 10.225 - Requirements for original merchant mariner credentials.

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Requirements for original merchant mariner credentials. 10.225 Section 10.225 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN MERCHANT MARINER CREDENTIAL General Requirements for All Merchant Mariner Credentials §...

  20. FORECASTING NIKKEI 225 INDEX WITH SUPPORT VECTOR MACHINE

    HUANG Wei; Yoshiteru Nakamori; WANG Shouyang; YU Lean

    2003-01-01

    Support Vector Machine (SVM) is a very specific type of learning algorithms characterized by the capacity control of the decision function, the use of the kernel functions and the sparsity of the solution. In this paper, we investigate the predictability of financial movement direction with SVM by forecasting the weekly movement direction of NIKKEI 225 index. To evaluate the forecasting ability of SVM, we compare the performance with those of Linear Discriminant Analysis, Quadratic Discriminant Analysis and Elman Backpropagation Neural Networks. The experiment results show that SVM outperforms other classification methods. Furthermore, we propose a combining model by integrating SVM with other classification methods. The combining model performs the best among the forecasting methods.

  1. 40 CFR 1048.225 - How do I amend my application for certification to include new or modified engine configurations?

    2010-07-01

    ... already covered by a certificate of conformity, you may start producing the new or modified engine... certification to include new or modified engine configurations? 1048.225 Section 1048.225 Protection of..., LARGE NONROAD SPARK-IGNITION ENGINES Certifying Engine Families § 1048.225 How do I amend my...

  2. 48 CFR 52.225-3 - Buy American Act-Free Trade Agreements-Israeli Trade Act.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Buy American Act-Free Trade Agreements-Israeli Trade Act. 52.225-3 Section 52.225-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.225-3...

  3. 12 CFR 225.145 - Limitations established by the Competitive Equality Banking Act of 1987 on the activities and...

    2010-01-01

    ... provisions of the Board's Regulation Y (12 CFR 225.52). 1 12 U.S.C. 1843(f). Such a company is treated as a..., credit card and mortgage lending. 12 CFR 225.25(b)(1). Finally, CEBA itself recognizes the specialized... a business. See 12 CFR 225.25(b)(3). Similarly, the trust company exemption from the bank...

  4. 12 CFR 225.130 - Issuance and sale of short-term debt obligations by bank holding companies.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Issuance and sale of short-term debt obligations by bank holding companies. 225.130 Section 225.130 Banks and Banking FEDERAL RESERVE SYSTEM... CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.130 Issuance and...

  5. Importance of maintenance therapy in C225-induced enhancement of tumor control by fractionated radiation

    Purpose: C225 strongly enhances tumor radioresponse when given concurrently with radiotherapy. We investigated whether additional therapeutic benefit could be achieved by continuing maintenance treatment with C225 after the completion of fractionated radiotherapy. Methods and Materials: A431 xenografts were treated with local irradiation or combined with C225 by two different schedules: (1) 6 h before the first dose of irradiation and at 3-day intervals for a total of 3 doses during the 7-day fractionated radiotherapy, or (2) 6 doses of C225 given both during radiotherapy and continuing for 3 additional doses after radiotherapy. Tumor cure was assessed by the radiation dose yielding local tumor control in 50% of animals (TCD50), and time to recurrence was also determined. Results: Both treatment schedules increased radiocurability as evidenced by reductions in TCD50, but the effect was greater when C225 was given both during and after radiotherapy. C225 reduced the TCD50 of 83.1 (73.2-124.8) Gy by radiation only to 46.2 (39.1-57.5) Gy when given during radiotherapy and to 30.8 (22.2-38.0) Gy when given during and after radiotherapy. Dose modification factors were 1.8 when C225 was given during radiotherapy and 2.7 when given both during and after radiotherapy. C225 was also effective in delaying the onset of tumor recurrences, and was more effective when given as both concurrent and maintenance therapy. Conclusions: Data showed that C225 strongly enhanced the curative effect of fractionated radiation, and its effect was greater if administration was extended beyond the end of radiotherapy. This important finding may influence future designs of clinical trials combining anti-EGFR (anti-epidermal growth factor receptor) agents with radiotherapy

  6. Results of the Test Program for Replacement of AK-225G Solvent for Cleaning NASA Propulsion Oxygen Systems

    Lowrey, Nikki M.; Mitchell, Mark A.

    2016-01-01

    Since the 1990's, when the Class I Ozone Depleting Substance chlorofluorocarbon-113 was banned, NASA's propulsion test facilities at Marshall Space Flight Center and Stennis Space Center have relied upon the solvent Asahiklin AK-225 (hydrochlorofluorocarbon-225ca/cb or HCFC-225ca/cb) and, more recently AK-225G (the single isomer form, HCFC-225cb) to safely clean and verify the cleanliness of large scale propulsion oxygen systems. Effective January 1, 2015, the production, import, export, and new use of Class II Ozone Depleting Substances, including AK-225G, was prohibited in the United States by the Clean Air Act. In 2012 through 2014, NASA test labs at MSFC, SSC, and Johnson Space Center's White Sands Test Facility collaborated to seek out, test, and qualify a solvent replacement for AK-225G that is both an effective cleaner and safe for use with oxygen systems. This paper summarizes the tests performed, results, and lessons learned.

  7. Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles

    Alpha radionuclide therapy is steadily gaining importance and a large number of pre-clinical and clinical studies have been carried out. However, due to the recoil effects the daughter recoil atoms, most of which are alpha emitters as well, receive energies that are much higher than the energies of chemical bonds resulting in decoupling of the radionuclide from common targeting agents. Here, we demonstrate that polymer vesicles (i.e. polymersomes) can retain recoiling daughter nuclei based on an experimental study examining the retention of 221Fr and 213Bi when encapsulating 225Ac. - Highlights: • First reported loading of 213Bi and 225Ac in polymer vesicles (i.e. polymersomes). • Encapsulating 225Ac in polymersomes results in up to 69 % recoil retention of 221Fr. • Encapsulating 225Ac in polymersomes results in up to 53 % recoil retention of 213Bi

  8. 25 CFR 225.29 - Corporate qualifications and requests for information.

    2010-04-01

    ... OIL AND GAS, GEOTHERMAL, AND SOLID MINERALS AGREEMENTS Minerals Agreements § 225.29 Corporate..., constitutes certification that the individual signing (except a surety agent) is authorized to act in such...

  9. Search for Electric dipole moment (EDM) in laser cooled and trapped 225Ra atoms

    Kalita, Mukut; Bailey, Kevin; Dietrich, Matthew; Green, John; Holt, Roy; Korsch, Wolfgang; Lu, Zheng-Tian; Lemke, Nathan; Mueller, Peter; O'Connor, Tom; Parker, Richard; Singh, Jaideep; Trimble, Will; Argonne National Laboratory Collaboration; University Of Chicago Collabration; University Of Kentucky Collaboration

    2014-05-01

    We are searching for an EDM of the diamagnetic 225Ra atom. 225Ra has nuclear spin I =1/2. Experimental sensitivity to its EDM is enhanced due to its heavy mass and the increased Schiff moment of its octupole deformed nucleus. Our experiment involves collecting laser cooled Ra atoms in a magneto-optical trap (MOT), transporting them 1 meter with a far off-resonant optical dipole trap (ODT) and then transferring the atoms to a second standing-wave ODT in our experimental chamber. We will report our recent experiences in polarizing and observing Larmor precession of 225Ra atoms in parallel electric and magnetic fields in a magnetically shielded region and progress towards a first measurement of the EDM of 225Ra. This work is supported by DOE, Office of Nuclear Physics, under contract No. DE-AC02-06CH11357 and contract No. DE-FG02-99ER41101.

  10. A two-dimensional phase separation on the spherical surface of the metallic glass Au55Pb22.5Sb22.5

    Lee, M. C.; Johnson, W. L.

    1982-01-01

    Recent experiments indicate that a phase separation in a spherical sample of the metallic glass Au55Pb22.5Sb22.5 occurs near the surface of the sphere. This strongly suggests either a contribution of surface-free energy to the decomposition process or a possible influence of near surface impurities absorbed during synthesis of the sphere. The surface phase separation has been studied as a function of cooling rate of the sphere. At high cooling rates (small sphere sizes), the surface separation disappears altogether suggesting that the surface of the parent liquid droplet is initially homogeneous.

  11. 12 CFR 225.127 - Investment in corporations or projects designed primarily to promote community welfare.

    2010-01-01

    ..., limited as to the rate of return on his investment in the project, as to rentals or occupancy charges for... (12 U.S.C. 1843(c)(8)) and § 225.25(b)(6) of the Board's Regulation Y (12 CFR 225.25(b)(6)) includes... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Investment in corporations or projects...

  12. Performance and beam characteristics of the PANTAK THERAPAX HF225 X-ray therapy machine

    The performance and beam characteristics of the new PANTAK THERAPAX HF225 X-ray therapy machine have been measured, evaluated and discussed. Eight beam qualities within the working range of generating potentials between 50 and 225 kVp are used in our department. These beam qualities have been investigated in order to provide a data base specific to our machine. Beam Quality, Central Axis Depth Dose, Output, Relative Field Uniformity and Timer Error were investigated. (authors)

  13. Auricular reconstruction of congenital microtia: personal experience in 225 cases.

    Anghinoni, M; Bailleul, C; Magri, A S

    2015-06-01

    Microtia is a congenital disease with various degrees of severity, ranging from the presence of rudimentary and malformed vestigial structures to the total absence of the ear (anotia). The complex anatomy of the external ear and the necessity to provide good projection and symmetry make this reconstruction particularly difficult. The aim of this work is to report our surgical technique of microtic ear correction and to analyse the short and long term results. From 2000 to 2013, 210 patients affected by microtia were treated at the Maxillo-Facial Surgery Division, Head and Neck Department, University Hospital of Parma. The patient population consisted of 95 women and 115 men, aged from 7 to 49 years. A total of 225 reconstructions have been performed in two surgical stages basing of Firmin's technique with some modifications and refinements. The first stage consists in fabrication and grafting of a three-dimensional costal cartilage framework. The second stage is performed 5-6 months later: the reconstructed ear is raised up and an additional cartilaginous graft is used to increase its projection. A mastoid fascial flap together with a skin graft are then used to protect the cartilage graft. All reconstructions were performed without any major complication. The results have been considered satisfactory by all patients starting from the first surgical step. Low morbidity, the good results obtained and a high rate of patient satisfaction make our protocol an optimal choice for treatment of microtia. The surgeon's experience and postoperative patient care must be considered as essential aspects of treatment. PMID:26246664

  14. 女性生殖管道发育异常225例临床分析%Clinical analysis of 225 women with congenital uterine malformation

    王世军; Mandakini Oli; 蒋励; 王建六; 魏丽惠

    2008-01-01

    目的 探讨子宫发育异常的发病情况、临床特征、诊治方法及其对生育的影响.方法 选取1990年3月-2005年1月北京大学人民医院收治的子宫发育异常患者225例的临床资料,进行回顾性分析,总结不同类型子宫发育异常的构成比、临床特征、诊治方法及对生育的影响.结果 (1)225例子宫发育异常患者中,中隔子宫125例,占55.6%,其中122例(97.6%,122/125)患者妊娠,但影响其妊娠结局,出现流产、胎位异常、早产、前置胎盘、胎膜早破等并发症.(2)双子宫51例,占22.7%(51/225);其中50例(98%,50/51)患者妊娠,对妊娠无明显影响;5例(10%,5/51)合并泌尿系统畸形.(3)残角子宫26例(11.6%,26/225),发生残角子宫妊娠4例(15%,4/26),残角子宫同侧输卵管妊娠1例(4%,1/26);2例(8%,2/26)合并泌尿系统畸形;合并不孕4例(15%,4/26).(4)双角子宫14例,占6.2%(14/225),无不孕患者,出现早产、胎膜早破等并发症;1例(7%,1/14)合并泌尿系统畸形.(5)其他类型:鞍状子宫4例(1.8%,4/225),无不孕患者;无子宫3例(1.3%,3/225),均以原发闭经就诊;单角子宫2例(0.9%,2/225),均合并不孕.结论 子宫发育异常中以中隔子宫最多见.中隔子宫、双子宫、双角子官、残角子宫、鞍状子宫对生育无明显影响,但在妊娠期可出现不同的并发症.子宫发育异常常合并泌尿系统畸形.无症状的子宫发育异常,可不予处理.%Objective To investigate the prevalence, clinical features, diagnosis, treatment and the influence on procreation of uterine malformation. Methods Totally 225 women with uterine malformation referred to our hospital from Mar 1990 to Jan 2005 were involved in this retrospective analysis.The constituent ratio, clinical feature, diagnosis, treatment and the influence on procreation were analyzed.Results (1) Among 225 cases of uterine malformation, 125 cases (55.6%) were septate uterus; 122(97.6%, 122/125 ) of these patients became pregnant, but

  15. 12 CFR 225.171 - What are the limitations on managing or operating a portfolio company held as a merchant banking...

    2010-01-01

    ... restrictions on such activities contained in §§ 225.28(b)(6) or 225.86(b)(1) of this part (12 CFR 225.28(b)(6... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What are the limitations on managing or operating a portfolio company held as a merchant banking investment? 225.171 Section 225.171 Banks...

  16. Composite outcomes in 2.25-mm drug eluting stents: a systematic review

    Background: Coronary atherosclerosis often involves small-caliber coronaries, yet the safety and efficacy of 2.25-mm DES have been poorly defined, with a general lack of separation of 2.25 with 2.5-mm performance. No randomized head-to-head 2.25 mm DES studies have been reported. There are several single-arm prospective studies, and we aim to systematically review all published specific 2.25-mm data to estimate composite DES-specific performance and highlight current knowledge gaps. Methods: We performed a systematic literature search of PubMed, EMBASE, Web of Science and Cochrane database for clinical trials of 2.25-mm DES. Angiographic and composite clinical outcomes were compared with descriptive statistics. Results: 2.25 mm-Paclitaxel (PES), sirolimus (SES), everolimus (EES) and platinum chromium EES DES-specific outcomes have been reported. Death at 12 months for SES, PES, EES and platinum chromium EES was 1.3%, 3.0%, 1.5%, and 4.4%. Rates of target vessel revascularization at 12 months for SES, PES, EES and platinum chromium EES were 5.7%, 13.3%, 8.8%, and 3.3%. Angiographic outcomes at 9 months to one year were as follows: mean late lumen loss (LLL) for SES, PES, and EES was 0.15 ± 0.11-mm, 0.28 ± 0.11-mm, and 0.16 ± 0.41-mm and mean diameter restenosis for SES, PES, and EES were 29.5 ± 6.2%, 34.7 ± 4.2%, and 20.9 ± 22.5%. Reported stent thrombosis rates for 2.25-mm DES were low ranging from 0% to 2.2% in up to 24-months of follow-up. Conclusions: This systematic review summarizes and tabulates all available specific data on 2.25-mm DES. Based on our descriptive analysis, 2.25-mm DESs have a favorable safety and efficacy profile for the treatment of very small coronary lesions. - Highlights: • Safety and efficacy of 2.25-mm DES have been poorly defined. • We performed a systematic review on all published 2.25 mm data to estimate composite DES-specific performance and highlight current knowledge gaps. • We pooled data from 9 clinical studies and 1

  17. Composite outcomes in 2.25-mm drug eluting stents: a systematic review

    Lee, Justin Z. [Department of Medicine, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ, 85724 (United States); Singh, Nirmal [Department of Cardiovascular Diseases, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States); Ortega, Gilbert [College of Medicine, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States); Low, See Wei; Kanakadandi, Uday [Department of Cardiovascular Diseases, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States); Fortuin, F. David [Department of Cardiovascular Diseases, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ, 85054 (United States); Lassar, Tom [Department of Cardiovascular Diseases, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States); Lee, Kwan S., E-mail: klee@shc.arizona.edu [Department of Cardiovascular Diseases, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States)

    2015-06-15

    Background: Coronary atherosclerosis often involves small-caliber coronaries, yet the safety and efficacy of 2.25-mm DES have been poorly defined, with a general lack of separation of 2.25 with 2.5-mm performance. No randomized head-to-head 2.25 mm DES studies have been reported. There are several single-arm prospective studies, and we aim to systematically review all published specific 2.25-mm data to estimate composite DES-specific performance and highlight current knowledge gaps. Methods: We performed a systematic literature search of PubMed, EMBASE, Web of Science and Cochrane database for clinical trials of 2.25-mm DES. Angiographic and composite clinical outcomes were compared with descriptive statistics. Results: 2.25 mm-Paclitaxel (PES), sirolimus (SES), everolimus (EES) and platinum chromium EES DES-specific outcomes have been reported. Death at 12 months for SES, PES, EES and platinum chromium EES was 1.3%, 3.0%, 1.5%, and 4.4%. Rates of target vessel revascularization at 12 months for SES, PES, EES and platinum chromium EES were 5.7%, 13.3%, 8.8%, and 3.3%. Angiographic outcomes at 9 months to one year were as follows: mean late lumen loss (LLL) for SES, PES, and EES was 0.15 ± 0.11-mm, 0.28 ± 0.11-mm, and 0.16 ± 0.41-mm and mean diameter restenosis for SES, PES, and EES were 29.5 ± 6.2%, 34.7 ± 4.2%, and 20.9 ± 22.5%. Reported stent thrombosis rates for 2.25-mm DES were low ranging from 0% to 2.2% in up to 24-months of follow-up. Conclusions: This systematic review summarizes and tabulates all available specific data on 2.25-mm DES. Based on our descriptive analysis, 2.25-mm DESs have a favorable safety and efficacy profile for the treatment of very small coronary lesions. - Highlights: • Safety and efficacy of 2.25-mm DES have been poorly defined. • We performed a systematic review on all published 2.25 mm data to estimate composite DES-specific performance and highlight current knowledge gaps. • We pooled data from 9 clinical studies and 1

  18. 12 CFR 225.104 - “Services” under section 4(c)(1) of Bank Holding Company Act.

    2010-01-01

    ... company chooses to have done through another organization. Moreover, the report of the Senate Banking and... Holding Company Act. 225.104 Section 225.104 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF... Holding Company Act. (a) Section 4(c)(1) of the Bank Holding Company Act, among other things, exempts...

  19. 21 CFR 2.25 - Grain seed treated with poisonous substances; color identification to prevent adulteration of...

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Grain seed treated with poisonous substances; color identification to prevent adulteration of human and animal food. 2.25 Section 2.25 Food and Drugs... identification to prevent adulteration of human and animal food. (a) In recent years there has...

  20. 12 CFR 225.175 - What risk management, record keeping and reporting policies are required to make merchant banking...

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What risk management, record keeping and reporting policies are required to make merchant banking investments? 225.175 Section 225.175 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK...

  1. 12 CFR 225.103 - Bank holding company acquiring stock by dividends, stock splits or exercise of rights.

    2010-01-01

    ... dividends, stock splits or exercise of rights. 225.103 Section 225.103 Banks and Banking FEDERAL RESERVE... holding company acquiring stock by dividends, stock splits or exercise of rights. (a) The Board of... bank stock splits without the Board's prior approval, and whether such a company may exercise,...

  2. 12 CFR 225.111 - Limit on investment by bank holding company system in stock of small business investment companies.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Limit on investment by bank holding company system in stock of small business investment companies. 225.111 Section 225.111 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES...

  3. 34 CFR 225.11 - What selection criteria does the Secretary use in evaluating an application for a Credit...

    2010-07-01

    ... evaluating an application for a Credit Enhancement for Charter School Facilities grant? 225.11 Section 225.11... application for a Credit Enhancement for Charter School Facilities grant? The Secretary uses the following criteria to evaluate an application for a Credit Enhancement for Charter School Facilities grant:...

  4. 78 FR 38093 - Thirteenth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

    2013-06-25

    ... Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is issuing this notice to advise the public of the twelfth meeting of the RTCA Special Committee 225, Rechargeable Lithium...

  5. 78 FR 16031 - Twelfth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

    2013-03-13

    ... Federal Aviation Administration Twelfth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is issuing this notice...

  6. 78 FR 6845 - Eleventh Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

    2013-01-31

    ... Federal Aviation Administration Eleventh Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is issuing this notice...

  7. 77 FR 39321 - Eighth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

    2012-07-02

    ... Federal Aviation Administration Eighth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Sizes AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Sizes. SUMMARY: The FAA is issuing this notice...

  8. 48 CFR 225.872-7 - Industrial security for qualifying countries.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Industrial security for... Agreements and Coordination 225.872-7 Industrial security for qualifying countries. The required procedures... qualifying country sources are in the DoD Industrial Security Regulation DoD 5220.22-R (implemented for...

  9. 77 FR 8325 - Sixth Meeting: RTCA Special Committee 225, Rechargeable Lithium Batteries and Battery Systems...

    2012-02-14

    ... Batteries and Battery Systems, Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Batteries and Battery Systems, Small and Medium Size. SUMMARY: The FAA is issuing this notice to advise the public of the sixth meeting of RTCA Special Committee 225, Rechargeable Lithium Batteries and...

  10. 77 FR 20688 - Seventh Meeting: RTCA Special Committee 225, Rechargeable Lithium Batteries and Battery Systems...

    2012-04-05

    ... Batteries and Battery Systems, Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Batteries and Battery Systems, Small and Medium Size. SUMMARY: The FAA is issuing this notice to advise the public of the seventh meeting of RTCA Special Committee 225, Rechargeable Lithium Batteries and...

  11. 48 CFR 225.7006-4 - Solicitation provision and contract clause.

    2010-10-01

    ... and contract clause. (a) Use the provision at 252.225-7037, Evaluation of Offers for Air Circuit Breakers, in solicitations requiring air circuit breakers for naval vessels unless— (1) An exception... Breakers, in solicitations and contracts requiring air circuit breakers for naval vessels unless— (1)...

  12. 47 CFR 25.225 - Geographic Service Requirements for 17/24 GHz Broadcasting Satellite Service.

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Geographic Service Requirements for 17/24 GHz... (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Technical Standards § 25.225 Geographic Service Requirements for 17/24 GHz Broadcasting Satellite Service. (a) Each operator of a 17/24 GHz BSS space...

  13. Determination of ''226Ra by Alpha Spectrometry by Using ''225Ra as Yield Tracer

    A method for the determination of low-level ''226 Ra in environmental and geological samples by alpha spectrometry is described. The method is based on the use of ''225 Ra from ''229 Th as yield tracer and has been developed to analyze U, Th and Ra in the same sample. (Author) 12 refs

  14. 20 CFR 405.225 - Notice of the Federal reviewing official's decision.

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Notice of the Federal reviewing official's... PROCESS FOR ADJUDICATING INITIAL DISABILITY CLAIMS Review of Initial Determinations by a Federal Reviewing Official § 405.225 Notice of the Federal reviewing official's decision. We will mail a written notice...

  15. 25 CFR 225.35 - Inspection of premises; books and accounts.

    2010-04-01

    ... records pertaining to a minerals agreement shall be maintained by an operator in accordance with 30 CFR... 25 Indians 1 2010-04-01 2010-04-01 false Inspection of premises; books and accounts. 225.35...; books and accounts. (a) Operators shall allow Indian mineral owners, their authorized...

  16. A=225 implantation for $^{221}$Fr source for TRIUMF atom trap

    The FrPNC Collaboration is mounting an atom trap for parity violation experiments and precision spectroscopy on francium atoms at TRIUMF's ISAC facility. We would like to use ISOLDE's capability of simultaneously implanting A=225 (while another experiment runs online) to make a long-lived source feeding $^{221}$Fr for tests of the trap. $^{225}$Ra $\\beta$-decays to $^{225}$Ac, which then $\\alpha$-decays, producing 100 keV $^{221}$Fr t$_{1/2}$= 4.8 minute recoils. The implanted A=225 source would be shipped to TRIUMF, where it would be held for several minutes at a time a few mm from the same yttrium foil that normally receives the ISAC beam. SRIM calculations imply that 20% of the $^{221}$Fr will be implanted in a 1 cm diameter spot on the yttrium. Then the yttrium foil is moved to the trap and heated to release the Fr atoms, just as in normal ISAC online operation. A test implantation will be done at 10$^{7}$/sec production for 1 day, testing whether carbon cracking on the implantation foil in the mass separ...

  17. 12 CFR 225.122 - Bank holding company ownership of mortgage companies.

    2010-01-01

    ... “incidental powers” clause. (See 1966 Federal Reserve Bulletin 1151; 12 CFR 208.119.) Accordingly, a bank... the 1958 Federal Reserve Bulletin at page 431 (12 CFR 225.104), the legislative history of the... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Bank holding company ownership of...

  18. First Measurement of the Permanent Electric Dipole Moment of Radium-225

    Singh, Jaideep T.; Bailey, K. G.; Bishof, M. N.; Dietrich, M. R.; Greene, J. P.; Holt, R. J.; Kalita, M. R.; Korsch, W.; Lemke, N. D.; Lu, Z.-T.; Mueller, P.; O'Connor, T. P.; Parker, R. H.

    2015-04-01

    Electric dipole moments (EDMs) are signatures of time-reversal (T), parity (P),& charge-parity (CP) violation. CP -violation beyond the Standard Model is generally believed to be required to explain the observed prevalence of matter over antimatter in the universe. Radium-225 (τ1 / 2 = 14 . 7 d, I = 1 / 2) is mostly sensitive to T- and P-violating interactions originating within the nucleus. The best limits on these types of exotic interactions are derived from the atomic EDM limit for Mercury-199. Because of its unusual nuclear structure (octupole deformation), Ra-225 is expected to have a physics sensitivity that is a few hundred to a few thousand times higher than Hg-199. Laser cooling & trapping techniques are performed to collect & transport the cold Ra atoms into the measurement region. An EDM measurement is then performed by searching for a linear electric field dependent shift in the nuclear spin precession frequency of Ra-225. We will report on the first measurement of the atomic EDM of Ra-225 as well as plans for future improvements. This work is supported by U.S. DOE, Office of Science, Office of Nuclear Physics, under Contract DE-AC02-06CH11357.

  19. 2 CFR Appendix B to Part 225 - Selected Items of Cost

    2010-01-01

    ... Part 225—Selected Items of Cost Table of Contents 1. Advertising and public relations costs 2. Advisory... related items of cost. 1. Advertising and public relations costs. a. The term advertising costs means the..., sections E. (“Direct Costs”) and F. (“Indirect Costs”) are observed. f. Unallowable advertising and...

  20. CCD UBV Photometry and Kinematics of the Open Cluster NGC 225

    Bilir, S; Yontan, T; Guver, T; Bakis, V; Ak, T; Ak, S; Paunzen, E; Eker, Z

    2016-01-01

    We present the results of CCD $UBV$ photometric and spectroscopic observations of the open cluster NGC 225. In order to determine the structural parameters of NGC 225, we calculated the stellar density profile in the cluster's field. We estimated the probabilities of the stars being physical members of the cluster using the existing astrometric data. The most likely members of the cluster were used in the determination of the astrophysical parameters of the cluster. We calculated the mean radial velocity of the cluster as $V_{r}=-8.3\\pm 5.0$ km s$^{-1}$ from the optical spectra of eight stars in the cluster's field. Using the U-B vs B-V two-colour diagram and UV excesses of the F-G type main-sequence stars, the reddening and metallicity of NGC 225 were inferred as $E(B-V)=0.151\\pm 0.047$ mag and $[Fe/H]=-0.11\\pm 0.01$ dex, respectively. We fitted the colour-magnitude diagrams of NGC 225 with the PARSEC isochrones and derived the distance modulus, distance and age of the cluster as $\\mu_{V}=9.3\\pm 0.07$ mag, d...

  1. 12 CFR 225.43 - Procedures for filing, processing, publishing, and acting on notices.

    2010-01-01

    ... paragraph shall be in accordance with the Rules of Practice for Formal Hearings (12 CFR part 263). At the... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Procedures for filing, processing, publishing... (REGULATION Y) Regulations Change in Bank Control § 225.43 Procedures for filing, processing, publishing,...

  2. 12 CFR 225.143 - Policy statement on nonvoting equity investments by bank holding companies.

    2010-01-01

    ... agreement placing long-term restrictions on the rights of a holder of voting securities. (12 CFR 225.2(b)(4... their investments, prevent takeovers by others, and allow for sale of their options, warrants, or rights... distribution in the event of sale, have a much greater prospect of achieving consistency with the Act...

  3. 48 CFR 225.7303-3 - Government-to-government agreements.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government-to-government... Military Sales 225.7303-3 Government-to-government agreements. If a government-to-government agreement between the United States and a foreign government for the sale, coproduction, or cooperative...

  4. 27 CFR 70.225 - Suspension of running of period of limitation; assets of taxpayer in control or custody of court.

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Suspension of running of period of limitation; assets of taxpayer in control or custody of court. 70.225 Section 70.225 Alcohol... (Occupational) Tax Limitations § 70.225 Suspension of running of period of limitation; assets of taxpayer...

  5. The E2-25K ubiquitin-associated (UBA) domain aids in polyubiquitin chain synthesis and linkage specificity

    Research highlights: → We examine the role of a ubiquitin-associated (UBA) domain in an E2 enzyme. → The E2-25K UBA domain directs polyubiquitin chain linkage specificity. → The E2-25K UBA domain regulates length of polyubiquitin chains synthesized. -- Abstract: E2-25K is an ubiquitin-conjugating enzyme with the ability to synthesize Lys48-linked polyubiquitin chains. E2-25K and its homologs represent the only known E2 enzymes which contain a C-terminal ubiquitin-associated (UBA) domain as well as the conserved catalytic ubiquitin-conjugating (UBC) domain. As an additional non-covalent binding surface for ubiquitin, the UBA domain must provide some functional specialization. We mapped the protein-protein interface involved in the E2-25K UBA/ubiquitin complex by solution nuclear magnetic resonance (NMR) spectroscopy and subsequently modeled the structure of the complex. Domain-domain interactions between the E2-25K catalytic UBC domain and the UBA domain do not induce significant structural changes in the UBA domain or alter the affinity of the UBA domain for ubiquitin. We determined that one of the roles of the C-terminal UBA domain, in the context of E2-25K, is to increase processivity in Lys48-linked polyubiquitin chain synthesis, possibly through increased binding to the ubiquitinated substrate. Additionally, we see evidence that the UBA domain directs specificity in polyubiquitin chain linkage.

  6. Immunoscintigraphy with anti-225.28S for ocular melanoma - a comparison with histology and immunohistochemistry

    Aim: The purpose of this prospective study was to evaluate the value of immunoscintigraphy (ISG) with anti-225.28S in clinically suspected ocular melanoma. Methods: For this purpose standardized ISG was performed in 36 patients using both planar acquisition and emission computed tomography (ECT). Ocular melanoma was present in 31 patients. In 21 patients therapy was enucleation of the eye. These specimens were evaluated by histology and immunohistochemistry in 11 of 21 patients. Results: Regarding the clinical diagnosis, ISG was positive only in 15 of 31 patients with ocular melanoma, regarding histology in 11 of 21 and regarding immunohistochemistry in 5 of 6 patients with a positive immunoreaction. 5 patients showed no immunoreactivity, their ISG was negative. Conclusion: Thus a good correlation between ISG and immunohistochemistry was observed. However ISG using the cutaneous melanoma antibody 225.28S cannot be recommended for the diagnostic work-up of an ocular melanoma considering the poor immunoreactivity. (orig.)

  7. Elastic scattering of neutron from 40Ca at 65-225 MeV

    We show the radial behavior of real part and imaginary part of the calculated central optical potential for n - 40Ca elastic scattering at incident energies En = 65, 75, 85, 95, 107.5, 127.5, 155, 185, 225 MeV using Urbana V-14 and Hamada Johnston realistic interaction. In the present work, we have analyzed neutron elastic scattering data at 65, 75, 85, 107.5, 127.5, 155, 185, 225 MeV from 40Ca using optical model potential calculated in first order Brueckner theory from two sources. We have used Urbana V-14 soft core inter nucleon potential as well as hard core Hamada Johnston inter- nucleon potential. We denote the neutron-nucleus optical potential obtained using soft-core potential by V-14 and for the hard-core potential by HJ

  8. 内地50家企业入选2009年ENR225

    2009-01-01

    2009年9月5日,美国麦格劳·希尔建筑信息公司(McGraw—Hill)在其官方网站发布了2009年度ENR全球最大225家国际承包商排名,我国内地共有50家企业榜上有名。ENR的统计显示,全球225家最大国际承包商的海外经营业绩在2008年大幅飙升,完成海外营业额较上年度增长了25.7%。

  9. Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K.

    Helms, Kimberli M; Wilson, Randall C; Ogungbe, Ifedayo V; Setzer, William N; Twigg, Pamela D

    2011-10-01

    An extract of bark from the tropical rainforest plant Byrsonima crassifolia was screened for inhibition of diubiquitin formation by the human ubiquitin-conjugating enzyme E2-25K. Activity assays with both the full-length enzyme and a truncated, active catalytic UBC domain revealed that the extract contained inhibitory properties. Separation of the extract into individual components and additional screens identified vitexin as the active inhibitor. An IC50 for vitexin was calculated to be approximately 0.5 mM. Molecular modeling simulations were used to predict the mode of inhibition and NMR spectra were used to confirm the binding site of vitexin to E2-25K. PMID:22164771

  10. Which Option Pricing Model is the Best? High Frequency Data for Nikkei225 Index Options

    Ryszard Kokoszczyński; Paweł Sakowski; Robert Ślepaczuk

    2010-01-01

    Option pricing models are the main subject of many research papers prepared both in academia and financial industry. Using high-frequency data for Nikkei225 index options, we check the properties of option pricing models with different assumptions concerning the volatility process (historical, realized, implied, stochastic or based on GARCH model). In order to relax the continuous dividend payout assumption, we use the Black model for pricing options on futures, instead of the Black-Scholes-M...

  11. Structure of liquid heavy water from 20 deg.C to 225 deg.C

    Recent results concerning the investigation of microscopic water properties by means of time of flight neutron diffraction are presented. It is found that the mean distance among water molecules increases with the decrease of water temperature. This implies an increase in local fourfold coordination due to the increase in 'hydrogen bonds'. Such behavior is observed in time-of-flight diffraction experiments using constant volume measurements for temperature range from +20 deg.C to 225 deg.C. (authors)

  12. Structure of quinoprotein methylamine dehydrogenase at 2.25 A resolution.

    Vellieux, F. M.; Huitema, F; Groendijk, H; Kalk, K H; Jzn, J F; Jongejan, J.A.; Duine, J A; Petratos, K; DRENTH, J.; Hol, W. G.

    1989-01-01

    The three-dimensional structure of quinoprotein methylamine dehydrogenase from Thiobacillus versutus has been determined at 2.25 A resolution by a combination of multiple isomorphous replacement, phase extension by solvent flattening and partial structure phasing using molecular dynamics refinement. In the resulting map, the polypeptide chain for both subunits could be followed and an X-ray sequence was established. The tetrameric enzyme, made up of two heavy (H) and two light (L) subunits, i...

  13. Atmospheric Abundances, Trends and Emissions of CFC-216ba, CFC-216ca and HCFC-225ca

    Corinna Kloss

    2014-06-01

    Full Text Available The first observations of the feedstocks, CFC-216ba (1,2-dichlorohexafluoropropane and CFC-216ca (1,3-dichlorohexafluoropropane, as well as the CFC substitute HCFC-225ca (3,3-dichloro-1,1,1,2,2-pentafluoropropane, are reported in air samples collected between 1978 and 2012 at Cape Grim, Tasmania. Present day (2012 mixing ratios are 37.8 ± 0.08 ppq (parts per quadrillion; 1015 and 20.2 ± 0.3 ppq for CFC-216ba and CFC-216ca, respectively. The abundance of CFC-216ba has been approximately constant for the past 20 years, whilst that of CFC-216ca is increasing, at a current rate of 0.2 ppq/year. Upper tropospheric air samples collected in 2013 suggest a further continuation of this trend. Inferred annual emissions peaked 421 at 0.18 Gg/year (CFC-216ba and 0.05 Gg/year (CFC-216ca in the mid-1980s and then decreased sharply as expected from the Montreal Protocol phase-out schedule for CFCs. The atmospheric trend of CFC-216ca and CFC-216ba translates into continuing emissions of around 0.01 Gg/year in 2011, indicating that significant banks still exist or that they are still being used. HCFC-225ca was not detected in air samples collected before 1992. The highest mixing ratio of 52 ± 1 ppq was observed in 2001. Increasing annual emissions were found in the 1990s (i.e., when HCFC-225ca was being introduced as a replacement for CFCs. Emissions peaked around 1999 at about 1.51 Gg/year. In accordance with the Montreal Protocol, restrictions on HCFC consumption and the short lifetime of HCFC-225ca, mixing ratios declined after 2001 to 23.3 ± 0.7 ppq by 2012.

  14. Wind turbine test Vestas V27-225 kW

    Markkilde Petersen, S.

    1990-10-15

    The report describes fundamental measurements performed on a Vestas-V27-225 kW pitch regulated wind turbine. The measurements carried out and reported here comprises the power output, system efficiency, energy production, transmission efficiency, rotor power, rotor efficiency, air-brakes efficiency, structural dynamics, loads at cut-in and braking, yaw error statistics, flapwise root bending moment and rotor thrust. (author).

  15. Cavity Formation in Aluminium Irradiated with a Pulsating Beam of 225 MeV Electrons

    Singh, Bachu Narain; Bilde-Sørensen, Jørgen; Leffers, Torben;

    1984-01-01

    High-purity aluminium was irradiated with a pulsating beam of 225 MeV electrons to a maximum dose of 0.035 dpa with a helium generation rate of up to 17 appm/dpa. The irradiated samples contained cavities in the size range 5 to 70 nm. In a zone of up to 14 μm from the grain boundaries cavity size...

  16. Interplay of fission modes in mass distribution of light actinide nuclei 225,227Pa

    Dubey, R.; Sugathan, P.; Jhingan, A.; Kaur, Gurpreet; Mukul, Ish; Mohanto, G.; Siwal, D.; Saneesh, N.; Banerjee, T.; Thakur, Meenu; Mahajan, Ruchi; Kumar, N.; Chatterjee, M. B.

    2016-01-01

    Fission-fragment mass distributions were measured for 225,227Pa nuclei formed in fusion reactions of 19F + 206,208Pb around fusion barrier energies. Mass-angle correlations do not indicate any quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with existing data for induced fission of 224,226Th and 228U around barrier energies. Enhancement in mass variance of 225,227Pa nuclei at below-barrier energies shows evidence for presence of asymmetric fission events mixed with symmetric fission events. This is in agreement with the results of mass distributions of nearby nuclei 224,226Th and 228U where two-mode fission process was observed. Two-mode feature of fission arises due to the shell effects changing the landscape of the potential-energy surfaces at low excitation energies. The excitation-energy dependence of the mass variance gives strong evidence for survival of microscopic shell effects in fission of light actinide nuclei 225,227Pa with initial excitation energy ∼30-50 MeV.

  17. Guidance and considerations for implementation of INFCIRC/225/Rev.3, the physical protection of nuclear material

    The Physical Protection of Nuclear Material, INFCIRC/225/Rev.3, provides recommendations for the physical protection of nuclear material against theft in use, storage and transport, whether national or international and whether peaceful or military, and contains provisions relating to the sabotage of nuclear material or facilities. The recommendations contained in INFCIRC/225/Rev.3 detail the elements that should be included in a State's system of physical protection. It also recognizes the adverse health and safety consequences arising from the theft of nuclear material and the sabotage of nuclear material or facilities. Most industrial and developing countries use these recommendations to some extent in the establishment and operation of their physical protection systems. Although INFCIRC/225/Rev.3 provides recommendations for protecting materials and facilities from theft or sabotage, it does not provide in-depth details for these recommendations. In June 1996, the IAEA convened a consultants meeting to consider this matter. This report is the result of continuing discussions and drafts over a period of nine months. The intent of this guidance is to provide a broader basis for relevant State organizations to prescribe appropriate requirements for the use of nuclear materials which are compatible with accepted international practice

  18. Interplay of fission modes in mass distribution of light actinide nuclei 225,227Pa

    R. Dubey

    2016-01-01

    Full Text Available Fission-fragment mass distributions were measured for 225,227Pa nuclei formed in fusion reactions of 19F+206,208Pb around fusion barrier energies. Mass-angle correlations do not indicate any quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with existing data for induced fission of 224,226Th and 228U around barrier energies. Enhancement in mass variance of 225,227Pa nuclei at below-barrier energies shows evidence for presence of asymmetric fission events mixed with symmetric fission events. This is in agreement with the results of mass distributions of nearby nuclei 224,226Th and 228U where two-mode fission process was observed. Two-mode feature of fission arises due to the shell effects changing the landscape of the potential-energy surfaces at low excitation energies. The excitation-energy dependence of the mass variance gives strong evidence for survival of microscopic shell effects in fission of light actinide nuclei 225,227Pa with initial excitation energy ∼30–50 MeV.

  19. NOAA TIFF Image- 5m Bathymetry (Sun Illuminated- Azimuth 225) of St. Croix (Buck Island), US Virgin Islands, 2004

    National Oceanic and Atmospheric Administration, Department of Commerce — This georeferenced image represents 5 meter resolution bathymetry (sun illuminated with azimuth 225 and incline 45) of the north shore of St. Croix, US Virgin...

  20. Development of a Complex Geometry Standard Fixture and Solvent Evaluation Method fo Assessing Replacement Solvents for AK-225G Project

    National Aeronautics and Space Administration — The focus of this analysis was the development of a complex geometry test fixture and test method for determining solvent cleaning efficiency. AK-225 belongs to a...

  1. "Modeling and Forecasting the Volatility of the Nikkei 225 Realized Volatility Using the ARFIMA-GARCH Model"

    Isao Ishida; Toshiaki Watanabe

    2009-01-01

    In this paper, we apply the ARFIMA-GARCH model to the realized volatility and the continuous sample path variations constructed from high-frequency Nikkei 225 data. While the homoskedastic ARFIMA model performs excellently in predicting the Nikkei 225 realized volatility time series and their square-root and log transformations, the residuals of the model suggest presence of strong conditional heteroskedasticity similar to the finding of Corsi et al. (2007) for the realized S&P 500 futures vo...

  2. Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity

    Background and purpose: Inhibition of EGFR-function can induce radiosensitization in tumor cells. Purpose of our investigation was to identify the possible molecular mechanism of radiosensitization following treatment with anti-EGFR-antibody C225 (Cetuximab). Materials and methods: The effect of C225 on radiation response was determined in human cell lines of bronchial carcinoma (A549) and breast adenoma cells (MDA MB 231). The molecular effects of C225 on EGFR-function after irradiation were analyzed applying western blotting, immune-precipitation and kinase assays. Effects on DNA-repair were detected by quantification of γ-H2AX positive foci 24 h after irradiation. Results: The EGFR specific antibody C225 induced radiosensitization in A549 and also in MDA MB 231 cells. Radiosensitization in A549 was associated with blockage of radiation-induced EGFR transport into the nucleus, and immobilized the complex of EGFR with DNA-dependent protein kinase (DNA-PK) in the cytoplasm. As a consequence radiation-induced DNA-PK activation was abolished, a process that is essential for DNA-repair after radiation exposure. Likewise C225 treatment increased the residual amount of γ-H2AX-positive foci 24 h after irradiation in A549 and in MDA MB 231 cells. Conclusions: Our results suggest that irradiation induced DNA-PK activation-essential for DNA repair-may be hampered specifically by use of the anti-EGFR-antibody C225. This process is associated with radiosensitization

  3. Treatment of pancreatic cancer xenografts with Erbitux (IMC-C225) anti-EGFR antibody, gemcitabine, and radiation

    Purpose: To investigate treatment of human pancreatic cancer cell lines and xenografts with combinations of Erbitux (IMC-C225) anti-epidermal growth factor receptor (EGFR) antibody, gemcitabine, and radiation. Methods and Materials: BxPC-3 and MiaPaCa-2 human pancreatic carcinoma cells were treated in vitro for 24 h with IMC-C225 (5 μg/mL), then exposed to epidermal growth factor (EGF) (10 mM) for 5 min. Immunoblots were screened for EGFR expression and the ability of IMC-C225 to block EGF-induced tyrosine phosphorylation of EGFR. Cells were treated with IMC-C225 (5 μg/mL) on Day 0, the IC50 dose of gemcitabine on Day 1 for 24 h, followed by 3 Gy 60Co irradiation on Day 2, or the combination of each agent. For cell proliferation, cells were counted on Day 4, and for apoptosis, cells were stained with annexin V-FITC and propidium iodide, then analyzed by FACS. Cells were treated with the same single or multiple treatments and analyzed in a clonogenic cell survival assay. The effect of IMC-C225, gemcitabine, and radiation on the growth of BxPC-3 and MiaPaCa-2 tumor xenografts was determined. Athymic nude mice bearing established s.c. tumor xenografts of 6-8 mm diameter received 6 weeks of treatment with IMC-C225 (1 mg every 3 days x 6) alone or in combination with gemcitabine (120 mg/kg i.v. every 6 days x 6), and 6 weekly fractions of 3 Gy radiation on the days after gemcitabine administration. Tumor growth was measured with Vernier calipers. Results: BxPC-3 and MiaPaCa-2 cell lines expressed low levels of EGFR. IMC-C225 inhibited EGF-induced tyrosine phosphorylation of the EGF receptor on both cell lines. Treatment of cells with a combination of IMC-C225 + gemcitabine + radiation produced the highest induction of apoptosis and inhibition of proliferation in vitro. Combination treatment with IMC-C225, gemcitabine, and radiation produced 100% complete regression of MiaPaCa-2 tumors for more than 250 days, and the greatest growth inhibition of BxPC-3 tumors compared

  4. 22.5% efficient silicon heterojunction solar cell with molybdenum oxide hole collector

    Substituting the doped amorphous silicon films at the front of silicon heterojunction solar cells with wide-bandgap transition metal oxides can mitigate parasitic light absorption losses. This was recently proven by replacing p-type amorphous silicon with molybdenum oxide films. In this article, we evidence that annealing above 130 °C—often needed for the curing of printed metal contacts—detrimentally impacts hole collection of such devices. We circumvent this issue by using electrodeposited copper front metallization and demonstrate a silicon heterojunction solar cell with molybdenum oxide hole collector, featuring a fill factor value higher than 80% and certified energy conversion efficiency of 22.5%

  5. Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles.

    Wang, G; de Kruijff, R M; Rol, A; Thijssen, L; Mendes, E; Morgenstern, A; Bruchertseifer, F; Stuart, M C A; Wolterbeek, H T; Denkova, A G

    2014-02-01

    Alpha radionuclide therapy is steadily gaining importance and a large number of pre-clinical and clinical studies have been carried out. However, due to the recoil effects the daughter recoil atoms, most of which are alpha emitters as well, receive energies that are much higher than the energies of chemical bonds resulting in decoupling of the radionuclide from common targeting agents. Here, we demonstrate that polymer vesicles (i.e. polymersomes) can retain recoiling daughter nuclei based on an experimental study examining the retention of (221)Fr and (213)Bi when encapsulating (225)Ac. PMID:24374072

  6. Interplay of fission modes in mass distribution of light actinide nuclei 225,227Pa

    R Dubey; Sugathan, P; Jhingan, A.; Gurpreet Kaur; Ish Mukul; G. Mohanto; Siwal, D.; Saneesh, N.; T Banerjee; Meenu Thakur; Ruchi Mahajan; Kumar, N; Chatterjee, M. B.

    2016-01-01

    Fission-fragment mass distributions were measured for 225,227 Pa nuclei formed in fusion reactions of 19 F + 206,208 Pb around fusion barrier energies. Mass-angle correlations do not indicate any quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with exis...

  7. Time history solution program, L225 (TEV126). Volume 1: Engineering and usage

    Kroll, R. I.; Tornallyay, A.; Clemmons, R. E.

    1979-01-01

    Volume 1 of a two volume document is presented. The usage of the convolution program L225 (TEV 126) is described. The program calculates the time response of a linear system by convoluting the impulsive response function with the time-dependent excitation function. The convolution is performed as a multiplication in the frequency domain. Fast Fourier transform techniques are used to transform the product back into the time domain to obtain response time histories. A brief description of the analysis used is presented.

  8. Production of chi mesons in 225 GeV/c π-Be interactions

    Gamma rays associated with psi mesons have been studied in 225 GeV/c π-Be interactions. The psi-γ mass spectrum shows an excess of 47 +- 11 events above background centered at 3.531 GeV/c2 with an rms width of 22.4 MeV. Attributing this excess of events to the decay chi → psi γ implies that 38 +- 9 % of all psi mesons are produced by this mechanism. The experimental setup and results are detailed

  9. Laser-trapping of Ra-225 and Ra-226 with repumping by room temperature blackbody radiation

    Guest, J R; Scielzo, N. D.; Ahmad, I.; Bailey, K.; Greene, J. P.; Holt, R J; Lu, Z. -T.; O'Connor, T. P.; Potterveld, D. H.

    2007-01-01

    We have demonstrated Zeeman slowing and capture of neutral Ra-225 and Ra-226 atoms in a magneto-optical trap (MOT). The intercombination transition 1S0-3P1 is the only quasi-cycling transition in radium and was used for laser-cooling and trapping. Repumping along the 3D1-1P1 transition extended the lifetime of the trap from milliseconds to seconds. Room-temperature blackbody radiation was demonstrated to provide repumping from the metastable 3P0 level. We measured the isotope shift and hyperf...

  10. An 225Ac/213Bi generator system for therapeutic clinical applications: construction and operation

    A method for construction and operation of an 225Ac/213Bi generator capable of producing 25-100 mCi of 213Bi suitable for clinical antibody labeling is described. The generator has been designed to have an effective lifetime of several weeks, producing up to six therapeutic doses of radionuclide per day. To date, 57 clinical doses have been prepared and injected into patients using the described 213Bi generator. Factors such as radiation damage, radioprotection, iodide eluate chemistry, radiolabeling chemistry and radionuclidic purity are addressed

  11. Facile solvent extraction separation of Th-227 and Ac-225 based on room-temperature ionic liquids

    New separation methodologies for radioisotopes are crucial to many medical applications. In this work, the solvent extraction of Th-227 and Ac-225 based on ionic liquids (ILs) was investigated using N,N,N',N'-tetraoctyldiglycolamide (TODGA) or di(2-ethylhexyl)phosphoric acid (HDEHP) as an extractant. Four ILs, 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([C4mim][NTf2]), 1-butyl-3-methylimidazolium bis(perfluoroethanesulfonyl)imide ([C4mim][BETI]), 1-butyl-2,3-trimethyleneimidazolium (trifluoromethanesulfonyl)imide ([BuI5][NTf2]), and 1-benzyl pyridinium bis(trifluoromethanesulfonyl)imide ([PhCH2Py][NTf2]) with different cation or anion structural features were used as diluents for the separation of Th-227 and Ac-225. Excellent extraction efficiencies and selectivities were found for Th-227/Ac-225 when HDEHP was used as an extractant in these ILs. The effects of different extractant concentrations in ILs and different aqueous phase acidities on extraction efficiencies and selectivities of Th-227/Ac-225 are also presented. The success in separation of Th-227 and Ac-225 isotopes highlights great potentials of use of ionic liquids in isotope production. (orig.)

  12. Specific targeting of nasopharyngeal carcinoma cell line CNE1 by C225-conjugated ultrasmall superparamagnetic iron oxide particles with magnetic resonance imaging

    Dongbo Lin; Chunli Chen; Guangyuaa Hu; Qi Mei; Hong Qiu; Guoxian Long; Guoqing Hu

    2011-01-01

    An accurate definition of clinical target volume (CTV) is essential for the application of radiotherapy in nasopharvngeai carcinoma (NPC) treatment. A novel epidermal growth factor receptor (EGFR)-targeting contrast agent (C225-USPIO) was designed by conjugating ultrasmail superparamagnetic iron oxide (USPIO) nanoparticles with cetuximab (C225), to non-invasively define the CTV of tumor. The immunobinding activity of C225-USPIO to NPC cell line CNEI was confirmed by flow cytometry and immunofluorescence. The time-dependent accumulation of C225-USPIO in CNE1 cells was evaluated using Prussian blue staining. Targeted internalization and subcellular localization of C225-USPIO was confirmed by transmission electron microscope. The results indicated that C225-USPIO specifically bound to EGFR on the surface of CNEI cells and was taken up into the cell. The uptake of C225-USPIO by CNE1 cells increased significantly with time, when compared with human IgG-USPIO. In addition, 4.7 T magnetic resonance imaging (MRI) revealed that C225-USPIO had a capacity to accumulate in the CNE1 cells, with a resultant marked decrease in MRI T2-weighted signal intensity over time. These findings imply that C225-USPIO has the potential as an MRI contrast agent and can be employed to non-invasively detect early-stage NPC with EGFR overexpression. This provides sufficient theoretical basis for commencing in vivo experiments with the compound.

  13. Interplay of fission modes in mass distribution of light actinide nuclei 225,227Pa

    Dubey, R; Jhingan, A; Kaur, Gurpreet; Mukul, Ish; Mohanto, G; Siwal, D; Saneesh, N; Banerjee, T; Thakur, Meenu; Mahajan, Ruchi; Kumar, N; Chatterjee, M B

    2015-01-01

    Fission-fragment mass distributions were measured for 225,227Pa nuclei formed in fusion reactions of 19F + 206, 208Pb around fusion barrier energies. Mass-angle correlations do not indicate any quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with existing data for induced fission of 224, 226Th and 228U around barrier energies. Enhancement in mass variance of 225, 227Pa nuclei at below-barrier energies shows evidence for presence of asymmetric fission events mixed with symmetric fission events. This is in agreement with the results of mass distributions of nearby nuclei 224, 226Th and 228U where two-mode fission process was observed. Two-mode feature of fission arises due to the shell effects changing the landscape of the potential energy surfaces at low excitation energ...

  14. Challenges and opportunities in the search for electric dipole moment (EDM) in 225Ra atom

    Kalita, Mukut; Bailey, Kevin; Dietrich, Matthew; Greene, John; Holt, Roy; Korsch, Wolfgang; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas; Parker, Richard; Sulai, Ibrahim; Singh, Jaideep

    2011-10-01

    The observation of a permanent electric dipole moment (EDM) in a non-degenerate system would indicate violation of time reversal symmetry. 225Ra atom is a particularly attractive candidate for this search since it has a nuclear spin I = 1/2 and has a significant nuclear octupole deformation. This property increases the Schiff moment of the nucleus and therefore enhances the atomic EDM. The half life (t1/2 = 14.9 days) of 225Ra is sufficiently long to perform EDM searches. Our group has already demonstrated the trapping of laser cooled Ra atoms in a magneto-optical trap (MOT) and transferring them to a far off resonant optical dipole trap (ODT). We will discuss our recent progress on manipulation of ultra cold Ra atoms in the ODT, efforts in improving our laser systems and generation of electric and magnetic fields required for the measurement. This work is supported by DOE, Office of Nuclear Physics, under contract No. DE-AC02-06CH11357 and contract No. DE-FG02-99ER41101.

  15. Transport properties of icosahedral Al70Pd22.5Re7.5 quasicrystals

    We report the electrical and thermal transport properties, including electric resistivity (ρ), Seebeck coefficient (S) and thermal conductivity (κ) of icosahedral Al70Pd22.5Re7.5 quasicrystals in the temperature range between 10 and 300 K. Four Al70Pd22.5Re7.5 samples with a resistivity ratio R = ρ4.2K/ρ300K ranging from 10.2 to 84.4 were studied. The temperature-dependent resistivities increase with decreasing temperature for all samples, exhibiting a semiconductor-like behaviour. The Seebeck coefficients are positive for the large-R samples (R 26.3 and 84.4) in the entire temperature range, while S-values become negative for the small-R samples (R = 10.2 and 19.4) below about 120 K. The significant dependence on R of the Seebeck coefficient can be qualitatively understood in the pseudogap scenario. The temperature variation of the thermal conductivity for these materials is quite similar, with values less than 2.5 Wm-1K-1 in the temperature range we investigated. The dimensionless thermoelectric figure of merit (ZT) of this system is estimated to be two orders of magnitude smaller than that of conventional thermoelectric materials

  16. Development of Cr3C2-25(Ni20Cr) nanostructured coatings

    This study is divided in two parts. The first part is about the preparation of nanostructured Cr3C2-25(Ni20Cr) powders by high energy milling followed by characterization of the milled and the as received powder. Analyses of some of the data obtained were done using a theoretical approach. The second part of this study is about the preparation and characterization of coatings prepared with the nanostructured as well as the as received Cr3C2-25(Ni20Cr) powders. The high temperature erosion-oxidation (E-O) behavior of the coatings prepared with the two types of powders has been compared based on a technological approach. The average crystallite size of the Cr3C2-25(Ni20Cr) powder decreased rapidly from 145 nm to 50 nm in the initial stages of milling and thereafter decreased slowly to a steady state value of around 10 nm with further increase in milling time. This steady state corresponds to the beginning of a dynamic recovery process. The maximum lattice strain (ε = 1,17%) was observed in powders milled for 16 hours, and this powders critical crystallite size was 28 nm. In contrast, the lattice parameter attained a minimum for powders milled for 16 hours. Upon reaching the critical crystallite size, the dislocation density attained a steady state regime and all plastic deformation introduced in the material there after was in the form of events occurring at the grain boundaries, due mainly to grain boundary sliding. The deformation energy stored in the crystal lattice of the Cr3C2-25(Ni20Cr) powders milled for different times was determined from enthalpy variation measurements. These results indicated that the maximum enthalpy variation (δH = 722 mcal) also occurred for powders milled for 16 hours. In a similar manner, the maximum specific heat variation (δCp = 0,278 cal/gK) occurred for powders milled for 16 hours. The following mechanical properties of Cr3C2-25(Ni20Cr) coatings prepared using the HVOF thermal spray process were determined: Vickers micro

  17. Mechanism-based inhibition of a mutant Escherichia coli ribonucleotide reductase (cysteine-225----serine) by its substrate CDP.

    Mao, S. S.; Johnston, M I; Bollinger, J M; Stubbe, J.

    1989-01-01

    The B1 subunit of Escherichia coli ribonucleotide reductase (EC 1.17.4.1) has been overexpressed using the pT7-5/pGP1-2 system developed by Tabor and Richardson [Tabor, S. & Richardson, C. (1985) Proc. Natl. Acad. Sci. USA 82, 1074-1078]. This method has allowed the preparation of two mutant B1 subunits in which two of the four thiols postulated to be within the active site of the enzyme, Cys-225 and Cys-759, have been changed to serines. Incubation of the [Ser225]B1 mutant with the B2 subuni...

  18. Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for 223Ra and 225Ra for targeted alpha therapy

    Introduction: Targeted alpha therapy (TAT) has the potential for killing micro-metastases with minimum collateral damage to surrounding healthy tissue. In-vivo generator radionuclides, such as223Ra, 225Ra, and 225Ac, are of special interest for radiotherapeutic applications as they emit multiple α-particles during their decay. Utilizing appropriate carriers capable of retaining both the parent radioisotope as well as daughter products is important for the effective delivery of the radioisotope to the tumor site while mitigating global in vivo radiotoxicity. In this work, LaPO4 core and core + 2 shells nanoparticles (NPs) (NPs with 2 layers of cold LaPO4 deposited on the core surfaces) were synthesized containing either 223Ra or225Ra/225Ac, and the retention of the parents and daughters within the NPs in vitro was investigated. Methods: Core LaPO4 NPs were synthesized in aqueous solution by reacting 1 equivalent of La(NO3)3, along with few microcuries of either 223Ra or 225Ra/225Ac, with 1 equivalent of sodium tripolyphosphate (TPP) under moderate heating and purified by membrane dialysis. Core-shell NPs were also synthesized with one (core + 1 shell) and two (core + 2 shells) cold LaPO4 layers deposited onto the radioactive cores. The NPs were then characterized by transmission electron microscopy (TEM) and powder x-ray diffraction (XRD). Identification and quantification of radioactive parents and daughters released from the NPs in vitro were investigated using gamma-ray spectroscopy. Results: XRD and TEM analysis revealed that the NPs crystallized in the rhabdophane phase with mean diameters of 3.4 and 6.3 nm for core and core + 2 shells, respectively. The core LaPO4 NPs retained up to 88% of 223Ra over 35 days. However, in the core + 2 shells NPs, the retention of 223Ra and its daughter, 211Pb, was improved to > 99.9% over 27 days. Additionally, the retention of 225Ra/225Ac parents was > 99.98% and ~ 80% for the 221Fr and 213Bi daughters over 35 days for the

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    2010-01-01

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