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Sample records for actinium 224

  1. Extraction of actinium with di-(2-ethylhexyl)phosphoric acid from hydrochloric and nitric acid solutions

    The extraction of actinium with HDEHP from Cl- and NO3- systems has been investigated. It was found that extraction of actinium from HCl solutions is much better than from HNO3 solutions. Stability constants of actinium complexes Ac(X-)+2 with Cl- and NO3- ligands were determined. Our results show that the actinium formed less stable complexes with Cl- than with NO3- ligands. 5 refs., 3 figs., 1 tab. (author)

  2. The sorption of polonium, actinium and protactinium onto geological materials

    This paper describes a combined experimental and modeling program of generic sorption studies to increase confidence in the performance assessment for a potential high-level radioactive waste repository in Japan. The sorption of polonium, actinium and protactinium onto geological materials has been investigated. Sorption of these radioelements onto bentonite, tuff and granodiorite from equilibrated de-ionized water was studied under reducing conditions at room temperature. In addition, the sorption of actinium and protactinium was investigated at 60 C. Thermodynamic chemical modeling was carried out to aid interpretation of the results

  3. Separation of Actinium 227 from the uranium minerals

    The purpose of this work was to separate Actinium 227, whose content is 18%, from the mineral carnotite found in Gomez Chihuahua mountain range in Mexico. The mineral before processing is is pre-concentrated and passed, first through anionic exchange resins, later the eluate obtained is passed through cationic resins. The resins were 20-50 MESH QOWEX and 100-200 MESH 50 X 8-20 in some cased 200-400 MESH AG 50W-X8, 1X8 in other cases. The eluates from the ionic exchange were electrodeposited on stainless steel polished disc cathode and platinum electrode as anode; under a current ODF 10mA for 2.5 to 5 hours and of 100mA for .5 of an hour. it was possible to identify the Actinium 227 by means of its descendents, TH-227 and RA-223, through alpha spectroscopy. Due to the radiochemical purity which the electro deposits were obtained the Actinium 227 was low and was not quantitatively determined. A large majority of the members of the natural radioactive series 3 were identified and even alpha energies reported in the literature with very low percentages of non-identified emissions were observed. We conclude that a more precise study is needed concerning ionic exchange and electrodeposit to obtain an Actinium 227 of radiochemical purity. (Author)

  4. Spectroscopic and computational investigation of actinium coordination chemistry.

    Ferrier, Maryline G; Batista, Enrique R; Berg, John M; Birnbaum, Eva R; Cross, Justin N; Engle, Jonathan W; La Pierre, Henry S; Kozimor, Stosh A; Lezama Pacheco, Juan S; Stein, Benjamin W; Stieber, S Chantal E; Wilson, Justin J

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, Ac(III) reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between Ac(III) and Am(III) in HCl solutions indicate Ac(III) coordinates more inner-sphere Cl(1-) ligands (3.2±1.1) than Am(III) (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique Ac(III) chemical behaviour. PMID:27531582

  5. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    Fry, C; Thoennessen, M

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  6. Dissolution processes. [224 references

    Silver, G.L.

    1976-10-22

    This review contains more than 100 observations and 224 references on the dissolution phenomenon. The dissolution processes are grouped into three categories: methods of aqueous attack, fusion methods, and miscellaneous observations on phenomena related to dissolution problems. (DLC)

  7. Production of high-purity radium-223 from legacy actinium-beryllium neutron sources.

    Soderquist, Chuck Z; McNamara, Bruce K; Fisher, Darrell R

    2012-07-01

    Radium-223 is a short-lived alpha-particle-emitting radionuclide with potential applications in cancer treatment. Research to develop new radiopharmaceuticals employing (223)Ra has been hindered by poor availability due to the small quantities of parent actinium-227 available world-wide. The purpose of this study was to develop innovative and cost-effective methods to obtain high-purity (223)Ra from (227)Ac. We obtained (227)Ac from two surplus actinium-beryllium neutron generators. We retrieved the actinium/beryllium buttons from the sources and dissolved them in a sulfuric-nitric acid solution. A crude actinium solid was recovered from the solution by coprecipitation with thorium fluoride, leaving beryllium in solution. The crude actinium was purified to provide about 40 milligrams of actinium nitrate using anion exchange in methanol-water-nitric acid solution. The purified actinium was then used to generate high-purity (223)Ra. We extracted (223)Ra using anion exchange in a methanol-water-nitric acid solution. After the radium was separated, actinium and thorium were then eluted from the column and dried for interim storage. This single-pass separation produces high purity, carrier-free (223)Ra product, and does not disturb the (227)Ac/(227)Th equilibrium. A high purity, carrier-free (227)Th was also obtained from the actinium using a similar anion exchange in nitric acid. These methods enable efficient production of (223)Ra for research and new alpha-emitter radiopharmaceutical development. PMID:22697483

  8. Radium, thorium, and actinium extraction from seawater using an improved manganese-oxide-coated fiber

    Laboratory experiments were conducted to determine the efficiency with which improved manganese-oxide-coated acrylic fibers extract radium, thorium, and actinium from seawater. Tests were made using surface seawater spiked with 227Ac, 227Th and 223Ra. For sample volumes of approximately 30 liters and flow rates up to 0.5 liters per minute, radium and actinium are removed quantitatively. Approximately 80-95% of the thorium is removed under these same conditions. (Auth.)

  9. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces ∼100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 GeV protons

  10. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  11. Groundwater seepage from the Ranger uranium mine tailings dam: radioisotopes of radium, thorium and actinium. Supervising Scientist report 106

    Monitoring of bores near the Ranger uranium mine tailings dam has revealed deterioration in water quality in several bores since 1983. In a group of bores to the north of the dam, increases have been observed of up to 500 times for sulphate concentrations and of up to 5 times for 226Ra concentrations. Results are presented here of measurements of members of the uranium, thorium and actinium decay series in borewater samples collected between 1985 and 1993. In particular, measurements of all four naturally-occurring radium isotopes have been used in an investigation of the mechanism of radium concentration changes. For the most seepage-affected bores the major findings of the study include: 228Ra/226Ra 223Ra /226Ra and 224Ra/228Ra ratios all increased over the course of the study; barium concentrations show high seasonal variability, being lower in November than May, but strontium concentrations show a steady increase with time. Calculations show that the groundwater is probably saturated with respect to barite but not with respect to celestite or anglesite; sulphide concentrations are low in comparison with sulphate, and are higher in November than in May; and 227Ac concentrations have increased with time, but do not account for the high 223Ra/226Ra ratios. It is concluded on the basis of these observations that increases in Ra isotope concentrations observed in a number of seepage-affected bores arise from increases in salinity leading to desorption of radium from adsorption sites in the vicinity of the bore rather by direct transport of radium from the tailings. Increased salinity is also causing the observed increases in 227Ac and strontium concentrations, while formation of a barite solid phase in the groundwater is causing the removal of some radium from solution. This is the cause of the increasing radium isotope ratios noted above

  12. 49 CFR 224.107 - Implementation schedule.

    2010-10-01

    ... brake test as prescribed by 49 CFR 232.305. (ii) A freight rolling stock owner may elect not to follow... 49 Transportation 4 2010-10-01 2010-10-01 false Implementation schedule. 224.107 Section 224.107... Maintenance of Retroreflective Material § 224.107 Implementation schedule. (a) Railroad freight cars....

  13. 33 CFR 117.224 - Thames River.

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Thames River. 117.224 Section 117.224 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.224 Thames River. The draw of the...

  14. 49 CFR 195.224 - Welding: Weather.

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions...

  15. Neutron-Induced Fission of Actinium-227, Protactinium-231 and Neptunium-237: Mass Distribution

    Results of radiochemical studies on the mass distribution in the neutron-induced fission of actinium-227, protactinium-231 and neptunium-237 have been presented. This work has been carried out as part of a programme to determine the mass distribution in the fission of heavy elements as a function of Z and A. All irradiations have been carried out in the core of the swimming-pool type reactor APSARA with cadmium shielding wherever necessary. Relative yields of several fission product nuclides have been obtained by a method involving a comparison of the fission product activities from the respective targets with those formed from uranium-235 simultaneously irradiated. Thermal-neutron fission yields of uranium-235 have been assumed. These results indicate a predominantly asymmetric mass distribution in all the three cases, and also a distinct though small symmetric peak in the case of actinium-227. (author)

  16. A new method for the determination of low-level actinium-227 in geological samples

    We developed a new method for the determination of 227Ac in geological samples. The method uses extraction chromatographic techniques and alpha-spectrometry and is applicable for a range of natural matrices. Here we report on the procedure and results of the analysis of water (fresh and seawater) and rock samples. Water samples were acidified and rock samples underwent total dissolution via acid leaching. A DGA (N,N,N',N'-tetra-n-octyldiglycolamide) extraction chromatographic column was used for the separation of actinium. The actinium fraction was prepared for alpha spectrometric measurement via cerium fluoride micro-precipitation. Recoveries of actinium in water samples were 80 ± 8 % (number of analyses n = 14) and in rock samples 70 ± 12 % (n = 30). The minimum detectable activities (MDA) were 0.017-0.5 Bq kg-1 for both matrices. Rock sample 227Ac activities ranged from 0.17 to 8.3 Bq kg-1 and water sample activities ranged from below MDA values to 14 Bq kg-1of 227Ac. From the analysis of several standard rock and water samples with the method we found very good agreement between our results and certified values. (author)

  17. 224-T TRUSAF Building upgrade

    This study considers the upgrades that would be necessary to extend the life of the Transuranic Waste Storage and Assay Facility (TRUSAF) for an additional 30 years. The study also considers cleanup and conversion of the canyon area of the building for storage of solid waste. The 224-T Building was constructed in the 1940s to support process operations of the T-Plant. The function of the facility has changed over the years, and at present the northern half of the building is used to store solid waste. This portion of the building is referred to as the TRUSAF. TRUSAF is one of only two onsite facilities licensed to receive and store solid TRU wastes. Original intentions were for TRUSAF to be used for TRU solid waste storage until the WRAP 1 Facility became operational

  18. 42 CFR 414.224 - Customized items.

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Customized items. 414.224 Section 414.224 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM PAYMENT FOR PART B MEDICAL AND OTHER HEALTH SERVICES Payment for Durable Medical...

  19. 22 CFR 224.34 - Evidence.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Evidence. 224.34 Section 224.34 Foreign....34 Evidence. (a) The ALJ shall determine the admissibility of evidence. (b) Except as provided in this part, the ALJ shall not be bound by the Federal Rules of Evidence. However, the ALJ may apply...

  20. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    Momeni, M.H.

    1981-09-01

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore.

  1. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore

  2. Cataracts in patients injected with 224Ra

    Cataracts were reported as of June 1984, by 6% (12/218) of patients injected with 224Ra as juveniles and by 5% (32/681) injected as adults. The high incidence among those injected as juveniles is unusual and their subsequent ages, when reporting the cataracts, averaged only 34 years (range 14-46 years). In the juveniles of known dosage receiving more than 28 μCi 224Ra/kg, the cataract incidence was 14% (11/80) compared to only 0.8% (1/131) below 28 μ Ci 224Ra/kg. The cataract incidence increased significantly with dosage in the juveniles and in the adults. The appearance of these cataracts, as viewed by slitlamp biomicroscopy or in histological sections, is described. The appearance did not differ from classical radiation cataract in principle. (orig.)

  3. In-source laser spectroscopy developments at TRILIS—towards spectroscopy on actinium and scandium

    Resonance Ionization Laser Ion Sources (RILIS) have become a versatile tool for production and study of exotic nuclides at Isotope Separator On-Line (ISOL) facilities such as ISAC at TRIUMF. The recent development and addition of a grating tuned spectroscopy laser to the TRIUMF RILIS solid state laser system allows for wide range spectral scans to investigate atomic structures on short lived isotopes, e.g., those from the element actinium, produced in uranium targets at ISAC. In addition, development of new and improved laser ionization schemes for rare isotope production at ISAC is ongoing. Here spectroscopic studies on bound states, Rydberg states and autoionizing (AI) resonances on scandium using the existing off-line capabilities are reported. These results allowed to identify a suitable ionization scheme for scandium via excitation into an autoionizing state at 58,104 cm − 1 which has subsequently been used for ionization of on-line produced exotic scandium isotopes.

  4. 22 CFR 224.2 - Definitions.

    2010-04-01

    ... Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224.2 Definitions. A.I.D. means the Agency for International Development. ALJ means an Administrative... organizational unit of A.I.D. in which the investigating official is employed; and (c) Is serving in a...

  5. Iron status markers in 224 indigenous Greenlanders

    Milman, N; Byg, K E; Mulvad, G;

    2001-01-01

    OBJECTIVE: To evaluate iron status in indigenous Greenlanders and its relationship to gender, age and intake of traditional Greenlandic foods. Methods: Serum ferritin, serum transferrin saturation and haemoglobin were evaluated in a population survey in 1993-1994 comprising 224 Greenlandic indivi...

  6. Dicty_cDB: SLF224 [Dicty_cDB

    Full Text Available SL (Link to library) SLF224 (Link to dictyBase) - - - Contig-U16200-1 SLF224Z (Link to Original ... qriprcrktrnrlqesqersc **ttttsyc*krsp*tpq*nlitqrch**vtt *sr*dqt*ignrncqqnrnakkdgrflw wfqslnqfdffliqc*kkkyyk ...

  7. 22 CFR 224.5 - Review by the reviewing official.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Review by the reviewing official. 224.5 Section... REMEDIES ACT § 224.5 Review by the reviewing official. (a) If, based on the report of the investigating official under § 224.4(b), the reviewing official determines that there is adequate evidence to...

  8. 38 CFR 21.224 - Prevention of abuse.

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Prevention of abuse. 21.224 Section 21.224 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED... Supplies § 21.224 Prevention of abuse. Supplies are to be furnished under the most careful checks by...

  9. The cataract response in radium 224 patients

    A group of 831 patients were studied, after injection with known dosages of radium 224 in Germany shortly after the Second World War. From a total of 58 cataract diagnoses, 25 occurred before the age of 54. Data consist of ophthalmological reports from examinations after vision impairment. Mathematical analysis suggests that almost all of the 25 early cataracts and a substantial part of the later cataracts are treatment-related. The probability of induction of severe cataracts is roughly proportional to the square of the dosage, that is, the radium 224 activity per unit body weight, and also to the square of the time after treatment. An extended analysis also accounts for spontaneous cataracts; this shows for the spontaneous cataracts a probability that increases with roughly the eighth power of the age. (author)

  10. Ammonium 2-(2,4-dichlorophenoxyacetate hemihydrate

    Hui-Lian Liu

    2009-08-01

    Full Text Available The title compound, NH4+·C8H7Cl2O6−·0.5H2O, was prepared by the reaction of 2-(2,4-dichlorophenoxyacetic acid and ammonia in water at 367 K. The molecular structure and packing are stabilized by N—H...O and O—H...O intermolecular hydrogen-bond interactions.

  11. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Raeder, S.; Bastin, B.; Block, M.; Creemers, P.; Delahaye, P.; Ferrer, R.; Fléchard, X.; Franchoo, S.; Ghys, L.; Gaffney, L. P.; Granados, C.; Heinke, R.; Hijazi, L.; Huyse, M.; Kron, T.; Kudryavtsev, Yu.; Laatiaoui, M.; Lecesne, N.; Luton, F.; Moore, I. D.; Martinez, Y.; Mogilevskiy, E.; Naubereit, P.; Piot, J.; Rothe, S.; Savajols, H.; Sels, S.; Sonnenschein, V.; Traykov, E.; Van Beveren, C.; Van den Bergh, P.; Van Duppen, P.; Wendt, K.; Zadvornaya, A.

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  12. The cataract response in radium 224 patients

    Enhanced incidence of severe cataracts has been observed in a group of 831 patients injected with Ra224 in Germany shortly after the 1939-45 war. From 58 diagnoses 25 occurred before the age of 54. There was a strong correlation between observed incidence and injected activity. Almost all the 25 early cataracts, and a substantial number of the later could be treatment-related. The probability of induction of severe cataracts is roughly proportional to the square of the time after treatment. Extended analysis also accounts for spontaneous cataracts, a probability increasing with roughly the eighth power of the age. (UK)

  13. 224Ra toxicity from a pilot study in beagles

    Toxicity data are reported for 20 beagles given single intravenous injections of 224Ra in 1963 or 1968. The injection of 1 μCi 224Ra/kg gave an average skeletal dose of about 54 rad in young adult beagles. Two dogs died of acute radiation sickness, 6 with bone sarcomas, 6 from other causes, and 6 were still alive on 31 March 1977. The acutely lethal dosage (LD/sub 50/30)/ for a single injection of 224 Ra in young adult beagles seems to lie between 10 and 20 μCi 224Ra/kg, with an average skeletal dose between 500 and 1000 rad

  14. Analysis of Radioactive Releases During Proposed Demolition Activities for the 224-U and 224-UA Buildings

    Napier, Bruce A.; Rishel, Jeremy P.; Droppo, James G.

    2009-03-31

    Atmospheric dispersion modeling has been conducted in support of the demolition of the 224-U and 224-UA buildings using estimated release rates to provide information on the location and levels of radioactive contamination that may be expected. The facilities surrounding the UO3 plant have the potential to affect dispersion patterns through various meteorological phenomena, including building wake effects. Hourly meteorological data collected over a 5-year period were used to examine the effects of wind speed, direction, and stability on projected concentrations of contaminants in air and deposited on nearby surfaces. The modeling results indicate that the radiological exposures from the planned demolition efforts will be below the designated limits for air and soil exposures.

  15. Brief history of 224Ra usage in radiotherapy and radiobiology

    Attempts were made a short time after its discovery to introduce 224Ra in therapy. Besides its external application in dermatology the treatment of rheumatic diseases seemed to be promising. From 1944-1952 about 2000 patients, most of them with tuberculosis or ankylosing spondylitis were treated in a German hospital with repeated intravenous injections of Peteosthor, a combination containing 224Ra with traces of platinum and eosin, totalling about 4000 μCi224Ra. Different lesions were observed which were suspected to be due to irradiation. The treatment has nevertheless continued. A group of 1500 additional patients, exclusively adults, has received rather low amounts (250-300 μCi) of 224Ra and are now under study. Based on linear hypothetical dose-effect relationships in this group an osteosarcoma incidence of 3-5 per 1000 patients could be expected during the first 20 years following average skeletal doses of 56 rad. In experiments started in 1965 in Neuherberg, Germany, the acute and late effects of 224Ra and 227Th in rats and mice are investigated. Similar experiments are under way in Czechoslovakia. In Salt Lake City, Utah, in connection with studies on boneseeking radioisotopes using dogs, a pilot study on 224Ra was started in 1963. Together with studies of Ra and Th toxicity a mock dial paint containing 224Ra and 234Th was developed. As 224Ra is a 232Th decay product, it might play a certain role in the Thorotrast problem. (author)

  16. Dicty_cDB: VSG224 [Dicty_cDB

    Full Text Available fsrrrpsdsasnndekfplkknhatpnhnshnrnsfdaqadkiraailpeirkdskvd lkkirssfivyrqskgyclncgksnhststcridpvdakan...irssfivyrqskgyclncgksnhststcridpvdakanpgpsakkqq*LDEGDESKS KILNKNYKISQYHHLEDNDYPVNKDSLYTLNSFYNQNIVKQLHQQSQQHD...me A: lxssreedlpiphrimmrsfh*krimllqiitlitgiplmhklirlelqyylk*ektlr* tskr*eavssftvraka...omology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value VSG224 (VSG224Q) /CSM/V...70Q.Seq.d/ 827 0.0 own update 2003. 1. 9 Homology vs DNA Score E Sequences producing significant

  17. Dicty_cDB: AFL224 [Dicty_cDB

    Full Text Available AF (Link to library) AFL224 (Link to dictyBase) - - - Contig-U08029-1 AFL224Z (Link to Original ... 152123_6( AC152123 |pid:none) Genomic sequence for broccoli ... [Bra... 83 2e-15 DQ980427_1( DQ980427 |pid:none) P ...

  18. Growth retardation in children injected with 224Ra

    We have obtained the adult heights of 133 patients formerly injected with 224Ra as juveniles. 224Ra induced growth retardation was greatest in children injected at young ages and increased with dose. The growth retardation was well represented as a 2% decrease in potential growth post irradiation per 100 rads of calculated average skeletal dose. (orig.)

  19. 224Ra and its implications in the East China Sea

    The activities of 224Ra in the East China Sea (ECS) were measured by the Mn-fiber adsorption-emanation method. The horizontal and vertical distributions of 224Ra in the ECS in summer and winter were studied. The ranges of 224Ra activities were 3 in summer with an average of 0.85 Bq/m3, and 3 in winter with an average of 0.72 Bq/m3. And the distributions of 224Ra in the surface water were similar in these two seasons, decreasing rapidly with the increasing distance from the coast. The high 224Ra area was located within 30-100 km offshore and the lowest activities appeared in the Kuroshio Current. The vertical distributions of 224Ra showed two different characteristics. The horizontal and vertical eddy diffusion coefficients calculated by the one-dimensional state model of 224Ra were (7.1-88.9) x 106 cm2/s and 2.18-163 cm2/s, respectively. The upwelling rates off Zhejiang Province were calculated from 224Ra vertical distribution, which varied from 8.4 x 10-3cm/s to 13.3 x 10-3cm/s in summer and 16.3 x 10-3cm/s to 16.8 x 10-3cm/s in winter. (author)

  20. 14 CFR 417.224 - Probability of failure analysis.

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Probability of failure analysis. 417.224..., DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.224 Probability of failure..., must account for launch vehicle failure probability in a consistent manner. A launch vehicle...

  1. Dicty_cDB: SLD224 [Dicty_cDB

    Full Text Available SL (Link to library) SLD224 (Link to dictyBase) - - - Contig-U01201-1 SLD224P (Link to Original ... 27k12, 5' ... 80 6e-27 2 ( DY588947 ) GUTF074981O3 POSSUM _01-POSSUM -GUT-2KB Trichosurus... 50 0.13 1 ( AM488 ...

  2. 47 CFR 36.224 - Extraordinary items-Account 7600.

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Extraordinary items-Account 7600. 36.224... Income Accounts Certain Income Accounts § 36.224 Extraordinary items—Account 7600. (a) Amounts in this account of an operating nature are apportioned on a basis consistent with the nature of these items....

  3. Dicty_cDB: SHH224 [Dicty_cDB

    Full Text Available SH (Link to library) SHH224 (Link to dictyBase) - - - Contig-U11458-1 SHH224P (Link to Original ... 2 Plasmodium falciparum 3D7 cDNA clone from Sugano malaria ... cDNA library: XPFn6930. 48 0.48 1 AU088296 |AU0882 ... 1 Plasmodium falciparum 3D7 cDNA clone from Sugano malaria ... cDNA library: XPFn6884. 48 0.48 1 AU087831 |AU0878 ...

  4. Reflection asymmetry in odd-A and odd-odd actinium nuclei

    Theoretical calculations and measurements indicate that octupole correlations are at a maximum in the ground states of the odd-proton nuclei Ac and Pa. It has been expected that odd-odd nuclei should have even larger amount of octupole-octupole correlations. We have recently made measurements on the structure of 224Ac. Although spin and parity assignments could not be made, two bands starting at 354.1 and 360.0 keV have properties characteristic of reflection asymmetric shape. These two bands have very similar rotational constants and also similar alpha decay rates, which suggest similarity between the wavefunctions of these bands. These signatures provide evidence for octupole correlations in these nuclides

  5. The biological effects of radium-224 injected into dogs

    A life-span study was conducted in 128 beagle dogs to determine the biological effects of intravenously injected 224Ra chloride. The 224Ra chloride was prepared by the same method used for intravenous injections in humans who were treated for ankylosing spondylitis and tuberculosis. Thus the results obtained from dogs can be compared directly to the population of treated humans, both for the elucidation of the effect of exposure rate and for comparison with other radionuclides for which data for humans are unavailable. Using equal numbers of males and females, the dogs were injected with one of four levels of 224Ra resulting in initial body burdens of approximately 13, 40, 120 or 350 kBq of 224Ra kg-1 body mass. A control group of dogs was injected with diluent only. All dogs were divided further into three groups for which the amount of injected 224Ra (half-life of 3.62 days) or diluent was given in a single injection or divided equally into 10 or 50 weekly injections. As a result of these three injection schedules, the accumulation of dose from the injected 224Ra was distributed over approximately 1, 3 or 12 months. Each injection schedule included four different injection levels resulting in average absorbed α-particle doses to bone of 0.1, 0.3, 1 and 3 Gy, respectively. The primary early effect observed was a hematological dyscrasia in the dogs receiving either of the two highest injection levels. The effect was most severe in the dogs receiving a single injection of 224Ra and resulted in the death of three dogs injected at the highest level. The late-occurring biological effects were tumors. Bone tumors were the most common followed by tumors in the nasal mucosa. 52 refs., 8 figs., 8 tabs

  6. Argonne-Utah studies of 224Ra endosteal surface dosimetry

    The activities of 212Pb relative to 224Ra and of 222Rn relative to 226Ra were measured in bone surface deposits 24 h after injection of radium into beagles. The fractional retention of 220Rn atoms was measured in vitro with hydrated and dehydrated bone samples to determine the effect of water content on the escape of radon from bone surfaces. The experimental data suggest that substantial 224Ra daughter-product disequilibrium exists in bone surface deposits. Estimates for the lower and upper limits on the fractional retention of 220Rn in vivo are 0.05 and 0.25, respectively. The average bone surface activity of 212Pb relative to 224Ra ranged from 0.34 to 0.71 for four dogs, with the majority of the values toward the lower end of the range. Only a small portion of the deposited 212Pb came from lead in the injection solution despite near equilibrium between 224Ra and its daughters at the time of injection. The retention data indicate that the endosteal tissue dose rate in the dogs at one day was actually one-third to about one-half that which would be calculated assuming equilibrium of 224Ra daughter products in bone surface deposits. 11 references, 2 figures, 7 tables

  7. Skeletal effects following 224Ra injections into humans

    Repeated injections of 224Ra into German patients have produced tooth breakage, growth retardation, benign exostoses, and malignant bone sarcomas. Tooth breakage was most frequent in adolescents 16-20 yr old at 224Ra injection. Growth retardation and exostoses were most frequent in the very young children and were not induced in adults. Bone sarcomas have occurred in 54 of the 897 traced patients of known and unknown dose, with appearance times ranging from 3.5 to 22 yr after 1st 224Ra injection. For patients of known dose and injection span, bone sarcomas occurred in 35 of 204 juveniles (1110 rad average skeletal dose and 11 months average injection span), and in 13 of 612 adults (210 rad average skeletal dose and 6 months average injection span). For equal injection spans, the juveniles were only slightly more sensitive per rad than the adults to 224Ra-induced bone sarcomas. The incidence of bone sarcomas from a given dose of 224Ra increased as the span of the injection series increased, and this effect in humans has been confirmed in the Neuherberg mice. (author)

  8. Structural integrity analysis of the 224U elevator mothballing

    As part of the preparation of Building 224U for turnover to Decontamination and Decommissioning, it is necessary to place the elevator in a mothballed condition so that it can be reactivated for use after 10 to 25 years. This mothballing is going to be accomplished by landing the counterweight on wooden timbers and suspending the elevator cab with wire rope or chain slings. This will take the load off the cables and make it relatively easy to reactive. The objective of this Supporting Document is to verify the structural integrity of all of the load bearing components involved in mothballing the 224U Building elevator. Building 224U is part of the UO3 Plant where uranyl nitrates from the PUREX Plant was converted to UO3 powder

  9. The biological effects of 224Ra injected into dogs

    The purpose of this study was to investigate the toxicity of injected 224Ra in the dog. Radium-224 is a short-lived isotope of radium with a half-life of 3.62 d. When administered parenterally, it deposits on bone surfaces; because of its short half-life, most of its energy is deposited on bone surfaces, in a manner similar to plutonium. The experimental design included a comparison to the exposed human population. Instead of using a single injection of 224Ra, groups were included in which dogs were injected once, 10 times, or 50 times. This design provided groups that could be compared to the multiple injections often used in people for the treatment of ankylosing spondylitis

  10. Risk and effect of radium-224 therapy of ankylosing spondylitis

    A total of 1426 patients suffering from Bechterew's disease who had formerly been treated with 224-Ra (up to 30 years ago), were included in an epidemiological study. The mean skeletal alpha dose amounted to 65 rad, the mean observation period was 16 years. Among the 363 mortalities recorded 3 were due to tumours in the skeletal region; of these, 2 were observed in the haemopoietic system. The types of the tumours detected deserve to be given particular attention: whereas osteosarcomas were almost the only tumours observed in a group of patients studied by Spiess, who had been treated with higher doses, no such tumour was revealed in the study population investigated here. Among the 3 tumours seen in this study group 2 were detected in the haemopoietic system as compared to 1 out of 55 tumours observed by Spiess. In contrast to this finding there was a remarkably high incidence of tumours of haemopoietic organs among the victims of Hiroshima. These results show that the relative benefits and disadvantages of the drug 224-Ra once again must be carefully considered. None of the chemical agents used in the treatment of ankylosing spondylitis is free from side-effects. A comparison of the latter with the risks involved in the use of 224-Ra leads to the conclusion that - according to the experience gained so far - 224-Ra is very useful in the treatment of this disease, if there is an absolute indication. (orig./MG)

  11. 48 CFR 52.224-2 - Privacy Act.

    2010-10-01

    ... individual that is maintained by an agency, including, but not limited to, education, financial transactions, medical history, and criminal or employment history and that contains the person's name, or the... AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.224-2...

  12. 42 CFR 436.224 - Individuals under age 21 who are under State adoption assistance agreements.

    2010-10-01

    ... assistance agency determines that— (i) At the time of the adoption placement, the child had special needs for... adoption assistance agreements. 436.224 Section 436.224 Public Health CENTERS FOR MEDICARE & MEDICAID....224 Individuals under age 21 who are under State adoption assistance agreements. (a) The agency...

  13. 77 FR 71474 - Seventeenth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2012-11-30

    ...). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY... Committee 224, Airport Security Access Control Systems. DATES: The meeting will be held December 13, 2012... Federal Aviation Administration Seventeenth Meeting: RTCA Special Committee 224, Airport Security...

  14. 78 FR 43963 - Twenty-Third Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2013-07-22

    ...). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY... Committee 224, Airport Security Access Control Systems. DATES: The meeting will be held on June 20, 2013... Federal Aviation Administration Twenty-Third Meeting: RTCA Special Committee 224, Airport Security...

  15. 77 FR 64838 - Sixteenth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2012-10-23

    ...). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY... Committee 224, Airport Security Access Control Systems. DATES: The meeting will be held November 15, 2012... Federal Aviation Administration Sixteenth Meeting: RTCA Special Committee 224, Airport Security...

  16. 78 FR 16757 - Twentieth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2013-03-18

    ...). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY... Committee 224, Airport Security Access Control Systems. DATES: The meeting will be held April 4, 2013 from 9... Federal Aviation Administration Twentieth Meeting: RTCA Special Committee 224, Airport Security...

  17. 78 FR 31627 - Twenty-Second Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2013-05-24

    ...). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY... Committee 224, Airport Security Access Control Systems. DATES: The meeting will be held on June 20, 2013... Federal Aviation Administration Twenty-Second Meeting: RTCA Special Committee 224, Airport Security...

  18. 78 FR 7850 - Nineteenth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2013-02-04

    ...). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY... Committee 224, Airport Security Access Control Systems. DATES: The meeting will be held February 21, 2013... Federal Aviation Administration Nineteenth Meeting: RTCA Special Committee 224, Airport Security...

  19. 77 FR 55894 - Fifteenth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2012-09-11

    ...). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY... Committee 224, Airport Security Access Control Systems DATES: The meeting will be held September 27-28, 2012... Federal Aviation Administration Fifteenth Meeting: RTCA Special Committee 224, Airport Security...

  20. 78 FR 22025 - Twenty First Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2013-04-12

    ...). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY... Committee 224, Airport Security Access Control Systems. DATES: The meeting will be held April 9-10, 2013... Federal Aviation Administration Twenty First Meeting: RTCA Special Committee 224, Airport Security...

  1. 22 CFR 224.40 - Stays ordered by the Department of Justice.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Stays ordered by the Department of Justice. 224.40 Section 224.40 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224.40 Stays ordered by the Department of Justice. If at any time...

  2. 50 CFR 224.105 - Speed restrictions to protect North Atlantic Right Whales.

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Speed restrictions to protect North Atlantic Right Whales. 224.105 Section 224.105 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE... AND ANADROMOUS SPECIES § 224.105 Speed restrictions to protect North Atlantic Right Whales. (a)...

  3. Exhalation pattern of thoron following incorporation of 224Ra

    The emanation factor (ω) of thoron was determined by means of thoron exhalation analysis as well as whole-body counting of 208Tl in 4 patients who had been injected intravenously with 224RaCl2 for treatment of Morbus Bechterew. At 5 hours after injection, ω was found to be 2.5 +- 0.3% remaining fairly constant during the period of examination (one week). (author)

  4. Fine structure in the alpha decay of {sup 224} U

    Lopez-Martens, A.; Hauschild, K.; Rezynkina, K. [CNRS-IN2P3, CSNSM, Universite Paris Sud, Orsay (France); Dorvaux, O.; Gall, B.; Dechery, F.; Faure, H. [CNRS-IN2P3, IPHC, Universite de Strasbourg, Strasbourg (France); Yeremin, A.V.; Chelnokov, M.L.; Chepigin, V.I.; Isaev, A.V.; Izosimov, I.N.; Katrasev, D.E.; Kuznetsov, A.N.; Kuznetsova, A.A.; Malyshev, O.N.; Popeko, A.G.; Sokol, E.A.; Svirikhin, A.I. [JINR, FLNR, Dubna (Russian Federation); Piot, J. [CNRS-IN2P3, GANIL, CEA-DSM, Caen (France); Rubert, J. [CNRS-IN2P3, IPHC, Universite de Strasbourg, Strasbourg (France); CNRS-IN2P3, LPSC, Universite Grenoble-Alpes, Grenoble (France)

    2014-08-15

    {sup 224}U nuclei were populated in fusion-evaporation reactions using a {sup 206}Pb target and an intense {sup 22}Ne beam. Fusion-evaporation residues were separated by the new separator SHELS at the FLNR, Dubna and implanted into a large-area double-sided silicon strip detector. Position- and time-correlated alpha decays were used to identify evaporation residues. A new α -decay line at 8095(11) keV was observed in this work and assigned as the decay from {sup 224}U to the first excited 2{sup +} in the daughter nucleus {sup 220}Th. Coincident photons were also observed allowing to unambiguously determine the excitation energy of the first excited 2{sup +} state in {sup 220}Th to be 386.5(1) keV and not 373.3(1)keV as previously reported. The half-life of {sup 224}U was measured to be 396(17)μs. (orig.)

  5. Malignancies in patients treated with high doses of radium-224

    Several thousand German patients suffering from ankylosing spondylitis, tuberculosis and some other diseases, received multiple injections of the short-lived α-emitter 224Ra. The ''Spiess study'' was initiated in the early 1950s to follow the health of 899 persons (278 female, 621 male) who were treated mainly between 1945 and 1955. Most of the high dose patients and nearly all of those treated as children or juveniles (n=217) were included in the study. In June 2003, 152 persons were still alive. The most striking observed health effect, following 224Ra injections, was a temporal wave of 56 malignant bone tumours with a maximum at about 8 years after exposure which has already been described in several publications. In 2000, a new analysis was performed because an improved dosimetry resulted in modified bone surface doses. The estimated risk coefficient, averaged over all ages at exposure, was found to be in agreement with earlier analyses. However, a statistically significant increase of bone tumour risk with decreasing age at exposure was found. The earlier results, which indicated a reversed protraction factor, were confirmed. A significant excess of non-skeletal solid malignancies has also appeared during the most recent observation decade. In 2004, significant increases of cancer rates were observed for several sites: for breast cancer (31 cases observed vs. 9.1 cases expected), soft tissue malignancies (11 vs. 1.0), thyroid carcinomas (7 vs. 0.9), liver (8 vs. 2.3), kidney (13 vs. 4.6), pancreas (8 vs. 3.9), and bladder cancer (14 vs. 7.7). The 8-fold excess relative risk of mammary cancers in those women exposed as children or juveniles is particularly striking; moreover, 2 cases of breast cancer occurred in men. In 1993, a control group of tuberculosis patients not treated with 224Ra was established to rule out potential confounding factors - such as chest fluoroscopy - which might bias the breast cancer excess. From the comparison it appeared, that the

  6. Estuarine geochemistry of 224Ra, 226Ra, and 222Rn

    Desorption from river borne sediments is the most likely source of the excess 226Ra. Laboratory mixing experiments on Pee Dee River sediments show an increase in 226Ra desorption with increasing salinities with maximum desorption occurring at or above 200/oo salinity. Desorption and diffusion are the sources for 226Ra in the estuarine systems. In Winyah Bay the 228Ra/226Ra activity ratio does not change significantly with salinity, averaging around 1.4, indicating desorption as the major source of 228Ra. In the Yangtze River the 228Ra/226Ra activity ratio is constant (approx.1.90) until increasing linearly above 160/oo. A diffusive flux from regeneration by 232Th decay in shelf sediments is the source of the increase. In Delaware Bay 228Ra increases faster than 226Ra in the less than or equal to220/oo water, indicating a source in addition to desorption. The increase can be balanced by a 0.33 dpm/cm2-year flux over the upper part of the Bay where fine grained sediments predominate. 224Ra behavior is controlled by its 3.64 day half-life. In Winyah Bay a flux of around 0.4 dpm/cm2-day is necessary to support the standing crop of non-desorbed 224Ra in the water column. In Delaware Bay the nearly constant 224Ra in concentration over the 2.50/oo to 120/oo salinity range are maintained by regeneration from 228Th in the turbidity maximum zones and diffusion from bottom sediments. Water leaving on ebb tide from a salt marsh on Delaware Bay had increases in all three radium isotopes (224Ra > 228Ra > 226Ra) compared to water coming in on the flood tide. Excess 222Rn concentrations in a fresh water section of the Pee Dee River show a decreasing downstream gradient. Using these gradients to determine evasion rates, stagnant film thicknesses range from 21μ to 62μ

  7. Epidemiological studies of German patients injected with Ra-224

    The health of 898 patients who received repeated injections of short-lived 224Ra after World War II, mainly for the treatment of tuberculosis and ankylosing spondylitis has been followed. As of 1980, 53 of these patients had developed bone sarcoma vs only 0.2 cases expected naturally. Two patients with bone sarcoma subsequently developed an additional bone sarcoma. No new bone sarcomas have been reported since the end of 1974. For the patients in each category, the tumor rate at every year after 224Ra injection was calculated by dividing the yearly number of bone sarcomas by the number of patients whose follow-up extended to that year. This corrected for the effects of death and incomplete follow-up. The yearly tumor rates were then summed to obtain the cumulative tumor rate. Dividing by the average skeletal dose in rads yielded the cumulative risk. The cumulative tumor risk was about 200 bone sarcomas/106 person rad of average skeletal dose and, with the dosimetric assumptions used, was not statistically different for (a) juveniles vs adults, (b) males vs females, or (c) TB patients vs spondylitic patients

  8. Dental extractions in relation to radiation therapy of 224 patients

    The case histories of 224 patients treated with radiation therapy for head and neck malignancies at the Radiotherapy Clinic of the Univesity Central Hospital in Turku during the years 1974-77 are reviewed. Of the 92 patients surviving for 5 years, 90 were available for re-examination. The median radiation dosage was 61 Gy in 6 to 8 weeks in patients with squamous cell carcinoma and othe solid tumours and 43 Gy in 5 weeks in patients with lymphoma. The oral status of the patients was examined clinically and radiographically. From these pationts 45 teeth had been extracted before irradiation and 94 after irradiation. In no case had this resulted in osteoradionecrosis of the jaws. It is evident that the repairing of patient's teeth before radiation treatment, coupled with continuous preventive care of caries, will prevent serious complications from arising. (author)

  9. 224Radium treatment (224SpondylAT trademark) in combination with an active as well as passive kinesitherapy on spondylitis ankylosans

    Over 1,000 patients had been treated at the Orthopedic University Halle using 224Radium in connection with active and passive kinesitherapy during the years of 1963-1988. A study had been done using 2 groups, 181 patients treated with 224Radium and 5-15 years later in comparison with a group of 122 patients not having been treated with 224Radium. With respect to the angle of kyphosis, the number of syndesmophyts, the size of syndesmophyts and the stadium of ossification in the area of the sacroiliacal joints, patients having been treated using the combination therapy (224Radium in connection with kinesitherapy) turned out to show significantly better results in comparison to the other group. (orig.)

  10. MiR-224 expression increases radiation sensitivity of glioblastoma cells

    Highlights: • MiR-224 expression in established glioblastoma cell lines and sporadic tumor tissues is low. • Exogenous miR-224 expression was found to increase radiation sensitivity of glioblastoma cells. • MiR-224 expression brought about 55–60% reduction in API5 expression levels. • Transfection with API5 siRNA increased radiation sensitivity of glioblastoma cells. • Low miR-224 and high API5 expression correlated with worse survival of GBM patients. - Abstract: Glioblastoma (GBM) is the most common and highly aggressive primary malignant brain tumor. The intrinsic resistance of this brain tumor limits the efficacy of administered treatment like radiation therapy. In the present study, effect of miR-224 expression on growth characteristics of established GBM cell lines was analyzed. MiR-224 expression in the cell lines as well as in primary GBM tumor tissues was found to be low. Exogenous transient expression of miR-224 using either synthetic mimics or stable inducible expression using doxycycline inducible lentiviral vector carrying miR-224 gene, was found to bring about 30–55% reduction in clonogenic potential of U87 MG cells. MiR-224 expression reduced clonogenic potential of U87 MG cells by 85–90% on irradiation at a dose of 6 Gy, a dose that brought about 50% reduction in clonogenic potential in the absence of miR-224 expression. MiR-224 expression in glioblastoma cells resulted in 55–65% reduction in the expression levels of API5 gene, a known target of miR-224. Further, siRNA mediated down-regulation of API5 was also found to have radiation sensitizing effect on glioblastoma cell lines. Analysis of the Cancer Genome Atlas data showed lower miR-224 expression levels in male GBM patients to correlate with poorer survival. Higher expression levels of miR-224 target API5 also showed significant correlation with poorer survival of GBM patients. Up-regulation of miR-224 or down-regulation of its target API5 in combination with radiation therapy

  11. MiR-224 expression increases radiation sensitivity of glioblastoma cells

    Upraity, Shailendra; Kazi, Sadaf; Padul, Vijay; Shirsat, Neelam Vishwanath, E-mail: nshirsat@actrec.gov.in

    2014-05-30

    Highlights: • MiR-224 expression in established glioblastoma cell lines and sporadic tumor tissues is low. • Exogenous miR-224 expression was found to increase radiation sensitivity of glioblastoma cells. • MiR-224 expression brought about 55–60% reduction in API5 expression levels. • Transfection with API5 siRNA increased radiation sensitivity of glioblastoma cells. • Low miR-224 and high API5 expression correlated with worse survival of GBM patients. - Abstract: Glioblastoma (GBM) is the most common and highly aggressive primary malignant brain tumor. The intrinsic resistance of this brain tumor limits the efficacy of administered treatment like radiation therapy. In the present study, effect of miR-224 expression on growth characteristics of established GBM cell lines was analyzed. MiR-224 expression in the cell lines as well as in primary GBM tumor tissues was found to be low. Exogenous transient expression of miR-224 using either synthetic mimics or stable inducible expression using doxycycline inducible lentiviral vector carrying miR-224 gene, was found to bring about 30–55% reduction in clonogenic potential of U87 MG cells. MiR-224 expression reduced clonogenic potential of U87 MG cells by 85–90% on irradiation at a dose of 6 Gy, a dose that brought about 50% reduction in clonogenic potential in the absence of miR-224 expression. MiR-224 expression in glioblastoma cells resulted in 55–65% reduction in the expression levels of API5 gene, a known target of miR-224. Further, siRNA mediated down-regulation of API5 was also found to have radiation sensitizing effect on glioblastoma cell lines. Analysis of the Cancer Genome Atlas data showed lower miR-224 expression levels in male GBM patients to correlate with poorer survival. Higher expression levels of miR-224 target API5 also showed significant correlation with poorer survival of GBM patients. Up-regulation of miR-224 or down-regulation of its target API5 in combination with radiation therapy

  12. 50 CFR 224.103 - Special prohibitions for endangered marine mammals.

    2010-10-01

    ... regulations at 36 CFR 13.65 that pertain specifically to the waters of Glacier Bay National Park and Preserve... mammals. 224.103 Section 224.103 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS ENDANGERED MARINE...

  13. 78 FR 51810 - Twenty-Fourth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2013-08-21

    ... Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control... RTCA Special Committee 224, Airport Security Access Control Systems. DATES: The meeting will be held...

  14. 77 FR 25525 - Thirteenth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems.

    2012-04-30

    ... Access Control Systems. AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems... Committee 224, Airport Security Access Control Systems DATES: The meeting will be held May 30, 2012, from...

  15. Multiple external-internal resorptions as late effects of Thorium X (224Ra)

    Multiple external-internal resorptions are infrequent and are related to a variety of etiological factors. Thorium X (224Ra) is believed to cause the dental resorptive changes observed in two patients who had received a series of injections each containing 8 to 70 μC1 of 224Ra 25 years previously. (author)

  16. MicroRNA-224 targets ERG2 and contributes to malignant progressions of meningioma

    Wang, Maomao; Deng, Xiaodong; Ying, Qi; Jin, Tingyan [The 411 Hospital of PLA, Department of Neurosurgery, 15 Dongjiangwan Road, Shanghai 200081 (China); Li, Ming [The 81 Hospital of PLA, Department of Neurosurgery, 34 Taiping Road, Nanjing 210002 (China); Liang, Chong, E-mail: liangchong1984@163.com [The 81 Hospital of PLA, Department of Neurosurgery, 34 Taiping Road, Nanjing 210002 (China)

    2015-05-01

    MicroRNA-224 is overexpressed in various malignant tumors with poor prognosis, which plays a critical role in biological processes including cell proliferation, apoptosis and several developmental and physiological progressions. However, the potential association between miR-224 and clinical outcome in patients with meningiomas remains unknown. Here, we investigate miR-224 expression and biological functions in meningiomas. MiR-224 expression was measured by Northern blot analysis and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in meningioma and normal brain tissues. Kaplan–Meier analysis and Cox regression analysis were used to exam its correlation with clinicopathological features and prognostic value. The biological effects of miR-224 on the cell proliferation and apoptosis in meningioma cells were examined by MTT assay and apoptosis assay. We found the expression levels of miR-224 were significantly higher in meningioma tissues than that in normal brain, positively correlated with advanced pathological grade. Kaplan–Meier analysis indicated that meningioma patients with low miR-224 expression exhibited significantly prolonged overall and recurrence-free survival. Furthermore, we demonstrated that ERG2 was an identical candidate target gene of MiR-224 in vitro. Our results indicated that downregulation of miR-224 suppressed cell growth and resulted in the enhancement of cell apoptosis through activation of the ERG2-BAK-induced apoptosis pathway. Our findings imply the miR-224 expression could predict the overall survival and recurrence-free survival of patients with meningioma and it might be a promising therapeutic target for treating malignant meningiomas. - Highlights: • MiR-224 expression is correlates with prognosis in meningioma patients. • ERG2 is a novel downstream target of miR-224. • MiR-224 suppressed cell growth and enhanced apoptosis in IOMM-Lee and CH157 cells. • MiR-224 is an upstream regulator of the ERG2

  17. MicroRNA-224 targets ERG2 and contributes to malignant progressions of meningioma

    MicroRNA-224 is overexpressed in various malignant tumors with poor prognosis, which plays a critical role in biological processes including cell proliferation, apoptosis and several developmental and physiological progressions. However, the potential association between miR-224 and clinical outcome in patients with meningiomas remains unknown. Here, we investigate miR-224 expression and biological functions in meningiomas. MiR-224 expression was measured by Northern blot analysis and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in meningioma and normal brain tissues. Kaplan–Meier analysis and Cox regression analysis were used to exam its correlation with clinicopathological features and prognostic value. The biological effects of miR-224 on the cell proliferation and apoptosis in meningioma cells were examined by MTT assay and apoptosis assay. We found the expression levels of miR-224 were significantly higher in meningioma tissues than that in normal brain, positively correlated with advanced pathological grade. Kaplan–Meier analysis indicated that meningioma patients with low miR-224 expression exhibited significantly prolonged overall and recurrence-free survival. Furthermore, we demonstrated that ERG2 was an identical candidate target gene of MiR-224 in vitro. Our results indicated that downregulation of miR-224 suppressed cell growth and resulted in the enhancement of cell apoptosis through activation of the ERG2-BAK-induced apoptosis pathway. Our findings imply the miR-224 expression could predict the overall survival and recurrence-free survival of patients with meningioma and it might be a promising therapeutic target for treating malignant meningiomas. - Highlights: • MiR-224 expression is correlates with prognosis in meningioma patients. • ERG2 is a novel downstream target of miR-224. • MiR-224 suppressed cell growth and enhanced apoptosis in IOMM-Lee and CH157 cells. • MiR-224 is an upstream regulator of the ERG2

  18. Determining coastal mixing rates of western Taiwan Strait using 224Ra

    224Ra concentrations in the coastal sea water of western Taiwan Strait in winter were measured using Mn-fiber adsorption-successive emanation scintillation method. 224Ra activities in the seawater of the western Taiwan Strait varied from 0.90 to 16.25 Bq/m3 with an average of 4.60 Bq/m3. The horizontal and vertical distributions of 224Ra were studied. The distributions of 224Ra in the surface water decreased gradually with increasing distance offshore. The apparent horizontal and vertical eddy diffusion coefficients estimated from the one dimensional steady state model of 224Ra were (5.0-55.4) x 106cm2/s and (4.0-51.7) cm2/s, respectively. (author)

  19. Optical spectrum of the planetary nebula M 2-24

    Zhang, Y

    2003-01-01

    We have obtained medium-resolution, deep optical long-slit spectra of the bulge planetary nebula (PN) M 2-24. The spectrum covers the wavelength range from 3610--7330 A. Over two hundred emission lines have been detected. The spectra show a variety of optical recombination lines (ORLs) from C, N, O and Ne ions. The diagnostic diagram shows significant density and temperature variations across the nebula. Our analysis suggests that the nebula has a dense central emission core. The nebula was thus studied by dividing it into two regions: 1) an high ionization region characterized by an electron temperature of T_e=16,300K and a density of logN_e(cm^{-3})=6.3; and 2) a low ionization region represented by T_e=11,400K and logN_e(cm^{-3})=3.7. A large number of ORLs from C, N, O and Ne ions have been used to determine the abundances of these elements relative to hydrogen. In general, the resultant abundances are found to be higher than the corresponding values deduced from collisionally excited lines (CELs). This b...

  20. {sup 224}Radium treatment ({sup 224}SpondylAT {sup trademark}) in combination with an active as well as passive kinesitherapy on spondylitis ankylosans; {sup 224}Radium-Behandlung ({sup 224}SpondylAT {sup trademark}) bei Morbus Bechterew in Kombination mit einer aktiven und passiven Bewegungstherapie

    Riede, D. [Halle-Wittenberg Univ., Halle (Germany). Orthopaedische Klinik

    2001-12-01

    Over 1,000 patients had been treated at the Orthopedic University Halle using {sup 224}Radium in connection with active and passive kinesitherapy during the years of 1963-1988. A study had been done using 2 groups, 181 patients treated with {sup 224}Radium and 5-15 years later in comparison with a group of 122 patients not having been treated with {sup 224}Radium. With respect to the angle of kyphosis, the number of syndesmophyts, the size of syndesmophyts and the stadium of ossification in the area of the sacroiliacal joints, patients having been treated using the combination therapy ({sup 224}Radium in connection with kinesitherapy) turned out to show significantly better results in comparison to the other group. (orig.) [German] Von 1963-1988 wurden in der Orthopaedischen Klinik Halle ueber 1000 Patienten mit {sup 224}Radium in Kombination mit einer aktiven und passiven Bewegungstherapie behandelt. 181 Patienten von {sup 224}Radium-Behandlung und 5-15 Jahre danach wurden mit einer Kontrollgruppe von 122 Patienten, die kein {sup 224}Radium bekommen hatten, verglichen. Im Hinblick auf den Kyphosewinkel, die Zahl der Syndesmophyten, die Syndesmophytengroesse und die Verknoecherungsstadien im Bereich der Iliosakralfugen fanden sich im Vergleich zu den Kontrollgruppen durchgehend signifikant bessere Ergebnisse bei den mit der Kombinationstherapie behandelten Patienten. (orig.)

  1. Bone sarcoma induction by 224Ra in Beagles: An interim report

    During 1963-1968, 20 young adult Beagle dogs were given a single intravenous injection of 224Ra that was unintentionally contaminated with 210Pb and 228Th. All of these dogs have died, eight with bone sarcomas. In addition, 128 Beagle dogs were given purified 224Ra in one, ten or fifty weekly injections during 1977-1979. The acute lethal dosage (LD50) for a single injection was about 400 kBq 224Ra/kg (11 μCi 224Ra/kg). As of September 14, 1987, at the highest skeletal dose of 3 Gy from purified 224Ra, bone sarcomas occurred in 5 of 6 dogs at an average ± SD of 2069 ± 302 days after the start of injections (no survivors), in 4 of 6 dogs at 2485 ± 1,110 days after the start of 10 injections (healthy survivor) and in 1 of 8 dogs at 3066 days after a single injection (3 healthy survivors). At 3 Gy the toxicity of 224Ra relative to 239Pu, based on the ratio of skeletal doses at equal tumor appearance times, was 1.0 for 50 injections of 224Ra, 0.7 for 10 injections, and 0.4 for one injection. In contrast, the effectiveness per Gy of a 224Ra-equivalent dose from a single injection of 224Ra contaminated with 228Th and 210Pb was equal to that from 239Pu, assuming that the 224Ra-equivalent dose equaled the 224Ra dose plus the 228Th dose pus 0.1 of the 210Pb dose. A possible explanation is that protracted irradiation from the 1.91-yr half-life 228Th and the 22.3-yr half-life 210Pb may have 'activated' residual damage from the short-lived, 3.62 day half-life 224Ra, possibly by stimulating the division of damaged stem cells to replace the bone cells killed by the protracted alpha particle irradiation. An important spin off from the study is experimental support for the assumption that the bone sarcoma effectiveness for 210Pb is similar to that from long-lived, 1600 yr half-life 226Ra. (author)

  2. Clinical Study of 224 Patients with Hypertriglyceridemia Pancreatitis

    Xiao-Li Zhang; Fei Li; Ya-Min Zhen; Ang Li; Yu Fang

    2015-01-01

    Background:Hypertriglyceridenia (HTG) is the most common etiology of acute pancreatitis (AP) after alcohol and gallstone-induced disease.Elevation of serum triglyceride (TG) levels to ≥ 1000 mg/dl in a patient with AP strongly indicates HTG as the cause.The absolute risk of pancreatitis based on serum TG ≤1000 mg/dl has not been clearly defined.The aims of this study were to address the role of elevated TG levels between 500 and 1000 mg/dl in the clinical course of HTG pancreatitis (HTGP);and assess the relationship between the level of serum TG and disease severity.Methods:A total of 224 HTGP patients between 2007 and 2011 were divided into two subgroups.Totally,122 patients in Group A had serum TG >1000 mg/dl;102 patients in Group B had maximal TG levels between 500 and 1000 mg/dl accompanied by lactescent serum;100 patients with biliary AP and 99 patients with alcoholic AP hospitalized during the study period were enrolled as controls.The clinical and biochemical data were analyzed.Results:The clinical presentation ofHTG-induced pancreatitis was similar to other causes.Severe form of AP in Group A was higher than Group B (x2 =4.002,P =0.045).The severity with HTGP was significantly higher as compared to biliaryAP (x2 =33.533,P =0.000) and alcoholic AP (x2 =7.179,P =0.007).Systemic complications with HTGP were significantly higher than biliary AP (x2 =58.763,P =0.000).Conclusions:The study demonstrated that TG level ≥500 mg/dl should raise a high degree of suspicion,especially if no other etiology of AP is apparent.The severity of HTGP seems to correlate directly with TG level.HTGP seems be more severe than other causes of AP.

  3. EFFECT OF FK224 ON THE BRONCHOCONSTRICTION INDUCED BY ISOCAPNIC HYPERPNEA IN GUINEA PIGS

    陶梦非; 梁永杰

    2005-01-01

    Objective To evaluate effect of Neurokinin receptor antagonist on the prevention from hyperpnea-induced bronchoconstriction using a dual Neurokinin receptor antagonist FK224. Methods 12 pathogenfree Hartley guinea pigs were divided into two groups randomly: Dimethyl sulfoxide (DMSO) control group (n =6)and FK224 group (n =6). Guinea pigs were anesthetized with pentobarbital sodium. A cervical tracheostomy was performed and a polyethylene tube was inserted into the trachea. After measuring baseline value of the lung resistance (RL) and dynamic compliance of respiratory system (Cdyn) , DMSO (0. 3ml/kg) and FK224 ( 1mg/kg) were administered by injection through jugular vein respectively. A rodent respirator with dry 5% CO2-95% O2 mixture at room temperature provided mechanical ventilation ( VT 8ml/animal, 100breaths/min ) for 5min. RL and Cdyn of 2groups were measured after isocapnic hyperpnea challenge. Results In DMSO control group, isocapnic hyperpnea of dry gas elicited a marked increase in RL and decrease in Cdyn. RL and Cdyn of FK224 group did not change significantly. Conclusion FK224 can inhibit the increase in RL and decrease in Cdyn caused by isocapnic hyperpnea in guinea pigs. And antagonists of tachykinins receptors might have effect on prophylaxis and treatment in exercise-induced asthma.

  4. Ra-224 for internal radiation therapy of spondylitis ankylosans (Bechterew's disease) - an alternative for chemotherapy

    For therapy of spondylitis ankylosans (Sp. a.) nowadays Ra-224 of high radionuclide purity in a dosage of 280 μCi total activity should be given a place beside the non-steroidal antirheumatic drugs. With comparable therapeutic efficacy and risk this substance has the advantage of improving the patients' quality of life without the relatively frequent and strained side effects of drug therapy. However, Ra-224 therapy has still a psychological disadvantage resulting from less positive experience with peteosthor therapy and application of external X-ray radiation. Ra-224 therapy is very safe concerning dosage by the physician, compared to drug therapy an overdosage by the patient is impossible. In future a comparison between Ra-224 therapy and peteosthor therapy performed with false indication and overdosage should be avoided. After careful examination of the type of the disease including a bone scan for evaluating the potential therapeutic success, up to now after application of Ra-224 of high radionuclide purity no severe side effects could be reported. (orig.)

  5. Using 224Ra to estimate eddy diffusivity and submarine groundwater discharge in Laizhou Bay, China

    The short-lived 224Ra isotope was measured in coastal water samples from Laizhou Bay, China using a radium delayed coincidence counting system. Based on the horizontal distribution of 224Ra and a mixing model, the horizontal eddy diffusion coefficient was estimated to be 253.1 x 106 and 56.5 x 106 m2/d for the surface and middle layers, respectively. The submarine groundwater discharge (SGD) into the bay was estimated on the basis of the 224Ra mass balance model. The estimate of the SGD into the bay is 4.2 x 108 m3/d, approximately six times the annual average flux of the Yellow River. (author)

  6. 224Ra and 226Ra experimentally induced dental changes in rats

    Sprague-Dawley rats received intragastrically a single dose of 226Ra or 224Ra once weekly for 21 weeks. During this period the animals of both groups were thus exposed to comparable doses. After 12 weeks, a shortening of the maxillary incisors was observed, and this progressed during the course of the 55-week experiment. Radiologically, a loss of pulpal transparency and an apical irregular opacity in the maxillary incisors were demonstrable. Histologically, dysplastic changes of the maxillary incisors and multiple resorptions at the cemento-enamel junction of the molars were seen. The observed alterations were more pronounced in the 226Ra group than in the 224Ra treated group. The experimentally induced resorptions were comparable to those observed in patients who had incorporated 224Ra or 226Ra. Clinical, radiological, histological, γspecrometrical, and autoradiographical findings, as well as dose-estimations, are described. (author)

  7. The induction by 224Ra of myeloid leukaemia and osteosarcoma in male CBA mice

    Radium-224 was injected into 12-week-old male CBA mice in the range 2-64 kBq per mouse either as a single injection or as eight injections spaced at 3.5 day intervals over 4 weeks. Small but significant yields of myeloid leukaemia or osteosarcoma were obtained in all but the control groups. An effect of mode of administration (single or multiple injections) could not be demonstrated but the combined results showed: (1) a maximum yield of myeloid leukaemia in the region 8-16 kBq 224Ra; (2) a greater yield of osteosarcoma than myeloid leukaemia at 64 kBq 224Ra injected. (author)

  8. 40 CFR 98.224 - Monitoring and QA/QC requirements.

    2010-07-01

    ... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Nitric Acid Production § 98.224 Monitoring and QA/QC... performance test annually. (2) Conduct the performance test when your nitric acid production process is... determine the production rate(s) (100 percent basis) from each nitric acid train during the performance...

  9. 77 FR 2343 - Eleventh Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2012-01-17

    ...). ACTION: Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY: The FAA..., Airport Security Access Control Systems. DATES: The meeting will be held February 9, 2012, from 10 a.m.-4..., Airport Security Access Control Systems. The agenda will include the following: February 9, 2012...

  10. 25 CFR 224.183 - What other administrative appeals processes also apply?

    2010-04-01

    ... DETERMINATION ACT General Appeal Procedures § 224.183 What other administrative appeals processes also apply? The administrative appeal processes in 25 CFR part 2 and 43 CFR part 4, subject to the limitations in... 25 Indians 1 2010-04-01 2010-04-01 false What other administrative appeals processes also...

  11. 77 FR 37732 - Fourteenth Meeting: RTCA Special Committee 224, Audio Systems and Equipment

    2012-06-22

    ... Equipment AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Audio Systems and Equipment. SUMMARY: The FAA is issuing... and Equipment. DATES: The meeting will be held July 11, 2012, from 10 a.m.-4 p.m. ADDRESSES:...

  12. 22 CFR 224.16 - Disqualification of reviewing official or ALJ.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Disqualification of reviewing official or ALJ... PROGRAM FRAUD CIVIL REMEDIES ACT § 224.16 Disqualification of reviewing official or ALJ. (a) A reviewing... with the ALJ a motion for disqualification of a reviewing official or ALJ. Such motion shall...

  13. Indications and results of a radium-224 (thorium x) therapy of ankylosing spondylitis (Sp.a.)

    224Ra treatment of ankylosing spondylitis with 1 i.v. injection of 28 μCi 224Ra per week and a total of 10 injections is indicated only for stages II and III of the disease if the inflammation of the small vertebral joints and iliosacral grooves are resistant to therapy and if the progressive ankylosis of the vertebral column can be proved by radiography and scintiscanning. It should not be applied, in general, during stage I, where only ilisacral arthritis can be diagnosed in the iliosacral grooves, and in stage IV, full-scale osseous ankylosis of the vertebral column with or without involvement of the extremity joints. Due to the antiosteoblastic action of the α radiation of 224Ra and the antiphlogistic action of the β and γ radiation released during the radioactive decay of 224Ra daughter products, the pain during stages II and III of a.sp. is greatly alleviated, and intensive gymnastic and balneological treatment during the 10 weeks' stay in hospital is made possible. Malignant bone tumours have never been observed so far, although the period of observation has been as long as 29 years in some cases. Even in those patients who died of tumours of the soft tissue, the rate was only 14% compared to the 20% rate in the normal population. (orig./MG)

  14. Use of nuclear recoil for separating 228Ra, 224Ra, and 233Pa from colloidal thorium

    By using α-recoil it is possible to separate by dialysis the α disintegration products (224 Ra; 228 Ra) of thorium from colloidal thorium hydroxide.The use of n, γ recoil allows the separation of 233Pa produced by the neutron irradiation of thorium, on condition that the colloidal thorium hydroxide is irradiated in the presence of a dispersing. (author)

  15. 10 CFR 431.224 - Uniform test method for the measurement of energy consumption for traffic signal modules and...

    2010-01-01

    ... consumption for traffic signal modules and pedestrian modules. 431.224 Section 431.224 Energy DEPARTMENT OF... measurement of energy consumption for traffic signal modules and pedestrian modules. (a) Scope. This section... traffic signal modules and pedestrian modules. For purposes of 10 CFR part 431 and EPCA, the...

  16. 25 CFR 224.115 - When in the petition process must the Director investigate a tribe's compliance with a TERA?

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false When in the petition process must the Director investigate a tribe's compliance with a TERA? 224.115 Section 224.115 Indians BUREAU OF INDIAN AFFAIRS... process must the Director investigate a tribe's compliance with a TERA? The Director must investigate...

  17. Closure Report for Corrective Action Unit 224: Decon Pad and Septic Systems, Nevada Test Site, Nevada

    Corrective Action Unit (CAU) 224 is located in Areas 02, 03, 05, 06, 11, and 23 of the Nevada Test Site, which is situated approximately 65 miles northwest of Las Vegas, Nevada. CAU 224 is listed in the Federal Facility Agreement and Consent Order (FFACO) of 1996 as Decon Pad and Septic Systems and is comprised of the following nine Corrective Action Sites (CASs): CAS 02-04-01, Septic Tank (Buried); CAS 03-05-01, Leachfield; CAS 05-04-01, Septic Tanks (4)/Discharge Area; CAS 06-03-01, Sewage Lagoons (3); CAS 06-05-01, Leachfield; CAS 06-17-04, Decon Pad and Wastewater Catch; CAS 06-23-01, Decon Pad Discharge Piping; CAS 11-04-01, Sewage Lagoon; and CAS 23-05-02, Leachfield. The Nevada Division of Environmental Protection (NDEP)-approved corrective action alternative for CASs 02-04-01, 03-05-01, 06-03-01, 11-04-01, and 23-05-02 is no further action. As a best management practice, the septic tanks and distribution box were removed from CASs 02-04-01 and 11-04-01 and disposed of as hydrocarbon waste. The NDEP-approved correction action alternative for CASs 05-04-01, 06-05-01, 06-17-04, and 06-23-01 is clean closure. Closure activities for these CASs included removing and disposing of radiologically and pesticide-impacted soil and debris. CAU 224 was closed in accordance with the NDEP-approved CAU 224 Corrective Action Plan (CAP). The closure activities specified in the CAP were based on the recommendations presented in the CAU 224 Corrective Action Decision Document (U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, 2005). This Closure Report documents CAU 224 closure activities. During closure activities, approximately 60 cubic yards (yd3) of mixed waste in the form of soil and debris; approximately 70 yd3 of sanitary waste in the form of soil, liquid from septic tanks, and concrete debris; approximately 10 yd3 of hazardous waste in the form of pesticide-impacted soil; approximately 0.5 yd3 of universal waste in the form of

  18. Closure Report for Corrective Action Unit 224: Decon Pad and Septic Systems, Nevada Test Site, Nevada

    NSTec Environmental Restoration

    2007-10-01

    Corrective Action Unit (CAU) 224 is located in Areas 02, 03, 05, 06, 11, and 23 of the Nevada Test Site, which is situated approximately 65 miles northwest of Las Vegas, Nevada. CAU 224 is listed in the Federal Facility Agreement and Consent Order (FFACO) of 1996 as Decon Pad and Septic Systems and is comprised of the following nine Corrective Action Sites (CASs): CAS 02-04-01, Septic Tank (Buried); CAS 03-05-01, Leachfield; CAS 05-04-01, Septic Tanks (4)/Discharge Area; CAS 06-03-01, Sewage Lagoons (3); CAS 06-05-01, Leachfield; CAS 06-17-04, Decon Pad and Wastewater Catch; CAS 06-23-01, Decon Pad Discharge Piping; CAS 11-04-01, Sewage Lagoon; and CAS 23-05-02, Leachfield. The Nevada Division of Environmental Protection (NDEP)-approved corrective action alternative for CASs 02-04-01, 03-05-01, 06-03-01, 11-04-01, and 23-05-02 is no further action. As a best management practice, the septic tanks and distribution box were removed from CASs 02-04-01 and 11-04-01 and disposed of as hydrocarbon waste. The NDEP-approved correction action alternative for CASs 05-04-01, 06-05-01, 06-17-04, and 06-23-01 is clean closure. Closure activities for these CASs included removing and disposing of radiologically and pesticide-impacted soil and debris. CAU 224 was closed in accordance with the NDEP-approved CAU 224 Corrective Action Plan (CAP). The closure activities specified in the CAP were based on the recommendations presented in the CAU 224 Corrective Action Decision Document (U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, 2005). This Closure Report documents CAU 224 closure activities. During closure activities, approximately 60 cubic yards (yd3) of mixed waste in the form of soil and debris; approximately 70 yd{sup 3} of sanitary waste in the form of soil, liquid from septic tanks, and concrete debris; approximately 10 yd{sup 3} of hazardous waste in the form of pesticide-impacted soil; approximately 0.5 yd{sup 3} of universal waste in

  19. WT1-mediated repression of the proapoptotic transcription factor ZNF224 is triggered by the BCR-ABL oncogene

    Montano, Giorgia; Vidovic, Karina; Palladino, Chiara; Cesaro, Elena; Sodaro, Gaetano; Quintarelli, Concetta; De Angelis, Biagio; Errichiello, Santa; Pane, Fabrizio; Izzo, Paola; Grosso, Michela; Gullberg, Urban; Costanzo, Paola

    2015-01-01

    The Kruppel-like protein ZNF224 is a co-factor of the Wilms’ tumor 1 protein, WT1. We have previously shown that ZNF224 exerts a specific proapoptotic role in chronic myelogenous leukemia (CML) K562 cells and contributes to cytosine arabinoside-induced apoptosis, by modulating WT1-dependent transcription of apoptotic genes. Here we demonstrate that ZNF224 gene expression is down-regulated both in BCR-ABL positive cell lines and in primary CML samples and is restored after imatinib and second generation tyrosine kinase inhibitors treatment. We also show that WT1, whose expression is positively regulated by BCR-ABL, represses transcription of the ZNF224 gene. Finally, we report that ZNF224 is significantly down-regulated in patients with BCR-ABL positive chronic phase-CML showing poor response or resistance to imatinib treatment as compared to high-responder patients. Taken as a whole, our data disclose a novel pathway activated by BCR-ABL that leads to inhibition of apoptosis through the ZNF224 repression. ZNF224 could thus represent a novel promising therapeutic target in CML. PMID:26320177

  20. miR-224-3p inhibits autophagy in cervical cancer cells by targeting FIP200.

    Fang, Wang; Shu, Shan; Yongmei, Li; Endong, Zhu; Lirong, Yin; Bei, Sun

    2016-01-01

    Cervical cancer (CC) is a malignant solid tumor, which is one of the main causes of morbidity and mortality in women. Persistent High-risk human papillomavirus (hrHPV) infection is closely related to cervical cancer and autophagy has been suggested to inhibit viral infections. miRNAs have been reported to regulate autophagy in many solid tumors with many studies implicating miR-224-3p in the regulation of autophagy. In this study, we performed a miRNA microarray analysis on CC tissues and found that a large number of miRNAs with differential expressions in hrHPV-infected tissues. We identified miR-224-3p as a candidate miRNA selectively up regulated in HPV-infected tissues and cell lines. Further analysis revealed that miR-224-3p regulates autophagy in cervical cancer tissues and cell lines. While the overexpression of miR-224-3p inhibits autophagy in HPV-infected cells, knocking down endogenous miR-224-3p increases autophagy activity in the same cells. In addition, we found that miR-224-3p directly inhibits the expression of autophagy related gene, FAK family-interacting protein of 200 kDa (FIP200). In summary, we found that miR-224-3p regulates autophagy in hrHPV-induced cervical cancer cells through targeting FIP200 expression. PMID:27615604

  1. Biological effects of 224Ra. Benefit and risk of therapeutic application

    The Second Symposium on the Biological effects of 224Ra, held at Neuherberg, was focused on two topical aspects of radiation protection. One aspect was the long-term effects of high-LET ionizing radiations on man and the quantitative data involved in risk assessment at low doses. The evaluation of epidemiological studies and experimental research was discussed in order to provide facts and figures contributing to an objective assessment of the radiation hazard from incorporated radionuclides. The other aspect was that of radiation protection in medicine. In the case of 224Ra treatment of ankylosing spondylitis the questions of benefit and risk of this therapeutic use of ionizing radiations were discussed, the aim being to achieve the therapeutic effect while reducing radiation exposure - and therefore the hazard - to a minimum. The proceedings contain the complete texts of 23 papers as well as the final round table discussions

  2. Investigation of 224Ra in the 226Ra (α,α'2n) reaction

    Positive and negative parity bands have been followed up to 10+ (possibly 12+) and 11- in 224Ra and are compared to the corresponding bands in the isotone 226Th. If a constant value of the intrinsic quadrupole moment is assumed for all E2 transitions in 224Ra the E1/E2 branching ratios are consistent with an intrinsic dipole moment of vertical strokeQ1vertical stroke=0.032(3) e.fm. This small value, as compared to vertical strokeQ1vertical stroke=0.30(2) e.fm for 226Th, can be explained by an almost complete cancellation of large positive liquid-drop and negative shell-model contributions. (orig.)

  3. Role of WT1-ZNF224 interaction in the regulation of leukemia cells apoptosis

    Montano, Giorgia

    2013-01-01

    The transcription factor Wilms’ tumour gene 1, WT1, is implicated both in normal developmental processes and in the generation of a variety of solid tumors and hematological malignancies. Physical interactions of other cellular proteins with WT1 are known to modulate its function. We previously identified the Krüppel-like zinc finger protein, ZNF224, as a novel human WT1-associating protein that enhances the transcriptional activation of the human vitamin D receptor promoter by WT1. Here, we ...

  4. Alkali activated materials state-of-the-art report, RILEM TC 224-AAM

    Deventer, Jannie

    2014-01-01

    This is a State of the Art Report resulting from the work of RILEM Technical Committee 224-AAM in the period 2007-2013. The Report summarises research to date in the area of alkali-activated binders and concretes, with a particular focus on the following areas: binder design and characterisation, durability testing, commercialisation, standardisation, and providing a historical context for this rapidly-growing research field.

  5. Fine structures in 14C emission of 223Ra and 224Ra

    The measurement of the energy spectrum of 14C nuclei emitted in the spontaneous radioactivity from 223Ra and 224Ra has been carried out, using thin and intense sources (480 MBq for 223Ra and 3550 MBq for 224Ra). The sources were obtained by implanting mass-separated beams from ISOLDE (CERN) into Al and vitreous C catchers. The measurement was performed with the supraconducting solenoidal spectrometer SOLENO installed at Orsay. The discovery, of a fine structure in the energy spectrum of 14C emission from 223Ra, which is analogous to the one known for α emission, is confirmed. Only 13% of the branching ratio in 14C decay leads to the ground state of the residual nucleus, while 8l% to the first excited state. For 14C emission of 224Ra, a lower limit of 2 for the hindrance factor has been measured for the transition to the first excited state in the residual nucleus. Also, a precise identification in Z with a E·ΔE telescope has been performed for the radiation from the 223Ra source. (author) 22 refs., 11 figs., 1 tab

  6. Fine structure in 14C emission from 223Ra and 224Ra

    The measurement of the energy spectrum of 14C nuclei emitted in the spontaneous radioactivity of 223Ra and 224Ra has been carried out, using thin and intense sources (480 MBq for 223Ra and 3550 MBq for 224Ra). The sources were obtained by implanting mass-separated beams into Al and vitreous C catchers. The measurement was performed with a superconducting solenoidal spectrometer. Our discovery, previously reported, of fine structure in the energy spectrum of 14C emission from 223Ra, which is analogous to the one known for α emission, is confirmed. Only 13% of the branching ratio in 14C decay leads to the ground state of the residual nucleus, while 81% to the first excited state. For 14C emission from 224Ra, a lower limit of 2 for the hindrance factor has been measured for the transition to the first excited state in the residual nucleus. Also, a precise identification in Z with an ExΔE telescope has been performed for the radiation from the 223Ra source. Our measurements of fine structure in 14C emissions open this field to nuclear structure studies

  7. Production of Osteosarcomas in Mice and Rats by Incorporation of Radium-224

    The effect of incorporated 224Ra has been investigated in mice and rats. The 3-4 week old mice received 5 - 200 μCi/kg body weight intraperitoneally as single doses and higher amounts as fractionated doses. Distribution and excretion studies lead to the calculated average skeleton dose of 28 rads/μCi/kg and an initial dose-rate of 8 rads/day and μCi/kg. So far about 6% of the 2506 experimental mice have developed osteosarcomas. The incidence was higher in the females than in the males. The shortest latency time was 5 months and the maximum incidence occurred at 17 to 18 months. No sarcomas were observed in the control animals. In some animals sarcomas appeared after doses of only 5 μCi. The optimum doses for tumour production were 50 - 100 μCi/kg. In 138 Wistar rats, which received 5-40 μCi of 224Ra/kg, 26 bone tumours have been observed so far. Besides mortality and tumour incidence the pathogenesis of late effects was followed by histological and histochemical studies. These studies show that a short-lived radioisotope may produce osteosarcomas. The experimental data are in good agreement with the clinical observation of osteosarcoma in man after treatment with 224Ra in childhood. (author)

  8. Clinical, para-clinical and subjective quality of life modifications after[224Ra] radium-chloride-therapy (224 SpondylAT) in ankylosing spondylitis (Bechterew's disease)

    Aim: The ankylosing spondylitis is a painful, chronically inflammatory illness which mainly manifests itself at the spine, and in addition at the peripheral joints with a pronounced inclination to reinforcement. Over the last years we again have been having the possibility to help the patients with a [224Ra]radium treatment to reduce the pain and probably stop the progress of the disease. The purpose was to examine the analgetic effect in connection with the para-clinical inflammation parameters and subjective modifications of the quality of life. Material and Methods: In our clinic, 5 patients (1 woman, 4 men) (age median 43,4 years) were treated over a period of 10 weeks with one weekly injection of 1 MBq [224Ra]radium chloride (224 SpondylAT). Before the therapy, at the last day of treatment, and 3 and 6 month after the therapy we documented the pain score (scale 1 to 10) of patients and the laboratory-chemical data (hemoglobin, leukocytes, neutrophile leukocytes, thrombocytes, CRP, blood sedimentation). Physical operability, psychological fortunes and the social role behavior was measured with the clinical test profile of quality of life chronically patients. The patients were asked retrospectively (approx. 5 to 15 months) to estimate their pre- and post-therapeutic situation. Results: Before the therapy, the inflammation parameters CRP (average 24.5) and BSR (average 47) of all patients were clearly increased. After 3 months, the CRP value showed a descending tendency, after 6 months however the starting value was almost reached again. The blood sedimentation rate was lowest 3 months after therapy; at a check after 6 months it was somewhat more higher, however still under the outgoing value. After 3 months, the pain score indicated by the patients was reduced from the first value of 7 significantly to 5,3, and after 6 months to 3,7. A significant modification of the blood cell parameters did not occur during the investigation period. 4 of 5 patients showed an

  9. C.I.颜料红224颜料化工艺改进%Improvement on Pigmentation of C.I. Pigment Red 224

    梁铁夫; 闫燕

    2012-01-01

    本文着重对C.I.颜料红224的颜料化工艺进行了改进.选用80%醋酸为颜料化介质,液固比15∶1,颜料化温度104~ 106℃的颜料化工艺,过滤得到的滤饼直接真空烘干.与传统的浓硫酸酸胀的工艺相比,解决了废酸水的污染问题,收率大幅提高,产品质量达到国外标准品质量.

  10. Analysis on incidence reason of 224 pulmonary tuberculosis patients%224例肺结核病人发病原因分析

    江秉态

    2013-01-01

    目的:探讨现阶段引起结核病发病的主要原因,为预防和控制结核病提供理论依据。方法:通过对旌阳区结核病防治所在2010年6月至2011年6月期间登记的224例新发涂阳肺结核病人进行回顾性问卷调查,对可能引起发病的原因进行分析。结果:224例肺结核病人中,有麻将史103例(46.0%),有网吧上网史38例(17.0%),有外出打工史20例(8.9%),有家人或同事患结核病14例(6.3%),同时有麻将史和打工史13例(5.8%),同时有麻将史和家庭接触史8例(3.6%),从事美容美发6例(2.6%),有在游戏厅玩游戏史的2例(0.9%),从事废品收购2例(0.9%),从事扫地工作1例(0.4%),其他17例(7.6%)。结论:在麻将馆打麻将和在网吧上网是目前引起结核病发病的主要原因,加强对麻将场馆和网吧等公共场所的监督与管理,并采取积极的干预措施势在必行。%Objective:To explore the main reason caused by tuberculosis at the present stage,to provide a theoretical basis for the prevention and control of tuberculosis. Methods:224 new smear-positive pulmonary tuberculosis patients who were registered during June 2010 to June 2011 in Jingyang District Tuberculosis Control Center were analyzed by retrospective questionnaires,to find the main reason of tuberculosis. Results:Among the 224 cases,103 cases with mahjong history(46.0%) ,38 cases with internet history (17.0%),20 cases with history of migrant workers(8.9%), 14 cases with family or colleagues suffering from tuberculosis(6.3%),13 cases with history of mahjong and migrant workers(5.8%),8 cases with history of mahjong and family or colleagues suffering from tuberculosis(3.6%), 8 cases with engaging in Beauty salon(2.6%),2 cases with history of playing games in the games room(0.9%),2 cases with engaging in the acquisition of waste(0.9%),1 case with engaging in sweeping work(0.4%), the other 17 cases(7

  11. Age related retention and dose burden after injection of 224Ra and 227Th in mice

    Incorporation of 224Ra in different aged female NMRI mice was investigated. The retention in skeleton (long bones) decreased continuously with age and remained constant after an age of about 10 months (decrease of percentage uptake from 50 to 25%). Rather similar conditions were found for the retention of 227Th, but with a somewhat smaller decrease (45 to 35%). These skeletal doses are often based on the values of femur concentration. In the case of mice, however, most bone tumours occur in the lumbar vertebrae, where the retention does not vary much with age. In contrast to the skeleton the retention of 224Ra was increased with age in the spleen, reaching concentrations even higher than that in the skeleton of old animals. It was remarkable that radium was retained in the spleen in this high concentration only when it was injected directly (as 224Ra) but much less, when it was given indirectly i.e. as the daughter nuclide 223Ra of its parent 227Th. If equal skeletal doses for different aged animals are to be intended, the reduced retention in the higher age has to be taken into account. Since dosage is mostly related to body weight (for instance Bq per kilogram) the resulting skeletal dose will be too small if the body weight and skeletal weight would be proportional. Since by the growth of fat tissue the body weight normally increases more than skeletal weight (after an age of a few months), the lowered retention might be more or less corrected for by relating to body weight. 3 refs.; 3 figs

  12. Auditable safety analysis for the surveillance and maintenance of the 224-B building

    The Plutonium Concentration Facility (224-B Building) is an inactive, surplus facility that operated from 1945 until 1976. This document provides the auditable safety analysis (ASA) for the post-deactivation, long-term surveillance and maintenance phase of the abovegrade structures of the 224-B Building. In this ASA, the ability of the existing facilities to withstand the effects of natural phenomena hazard events is evaluated and the support systems used to maintain ventilation and/or prevent the spread of contamination are described. The purpose of the S ampersand M phase is as follows: Maintain confinement of residual inventories of radioactive materials and other contaminants until the facility is ultimately dispositioned; Prevent deterioration of confinement structures; Respond to potential accident conditions requiring response and mitigation; Provide for the safety of workers involved in the S ampersand M phase; and Provide the basis for evaluation and selection of ultimate disposal alternatives. In this ASA, the ability of the existing facilities to withstand the effects of natural phenomena hazard (NPH) events is evaluated and the support systems used to maintain ventilation and/or prevent the spread of contamination are described. This document also evaluates S ampersand M activities that are routinely required (i.e., the S ampersand M of facility barriers, equipment, structures, and postings [including repair and upgrade]; measures to identify, remove, or repair damaged asbestos; measures to identify, remove, or appropriately manage existing containers of hazardous substances; nondestructive assay, waste characterization and sampling; and the performance of spill response measures as needed). The type and nature of the hazards presented by the 224-B Building and specific controls that are required to maintain these hazards to acceptable levels are also identified

  13. Determination of 226Ra and 224Ra in drinking waters by liquid scintillation counting

    A method for the determination of Ra-isotopes in water samples has been developed. Ra is coprecipitated with Ba as sulphate. The precipitate is then dissolved with EDTA and counted with a liquid scintillation system after mixing with a scintillation cocktail. The study of the temporal evolution of the separated activity gives the isotopic composition of the sample, i.e. the 224Ra and 226Ra contribution to the total activity. The method has been applied to some Spanish drinking waters. (author)

  14. Hyperon production inbar pp interactions at 22.4 GeV/ c

    Herynek, I.; Muríň, P.; Staroba, P.; Suk, M.; Šimák, V.; Valkárová, A.; Vávra, J.

    1993-07-01

    In the present paper we investigate the production of charged hyperons and antihy-perons inbar pp interactions at 22.4 GeV/ c recorded in the 2m hydrogen bubble chamber “Ludmila”. After correction for losses due to the kinematics of hyperon decays and for scanning efficiency we have obtained 610 events with charged hyperons or antihyperons. A total cross section of 1.3{-0.05/+0.4} mb for ∑±/overline {sum ^ ± } has been obtained, and various associated charged particle multiplicity distributions are presented.

  15. Analysis of elastic scattering in anti pp interactions at 22.4 Gev/c

    Results are presented on measuring the anti pp elastic scattering differential cross section at 22.4 GeV/c over a region of 0.05 2. The results have been obtained from pictures of the HBC ''Ludmila''. The total elastic cross section σsub(el)=9.0+-0.3 mb and the slope parameter b(s, t=0)=13.1+-0.8 GeVsup(-2) have been found from the data approximated by a quadratic exponential function. The results are compared with the data at similar energies

  16. 224例住院婴幼儿贫血病因分析%Analysis of the Cause of Anemia in 224 Cases of Infants and Young Children

    杨俊杰

    2015-01-01

    Objective To study the hospitalized infants and young children crowd in children with anemia, provide theoretical basis for the prevention and treatment of anemia in infants. Methods On 2010.8.1~2010.8.30 hospitalized in our department infant anemia investigation, to find the cause and fol ow-up. Results A total of 224 cases of infants and young children to complete fol ow-up. The most common etiology anemia is iron deficiency disease (69.4%), but 89.3% of them are mild, hemolytic anemia take second place, with favism is given priority to, and send out the Mediter anean anemia; Because of the repeated infection or third of anemia with other diseases. Conclusion Iron deficiency anemia is stil the infant anemia main reason, it is necessary to further strengthen the anemia prevention and control work.%目的探讨住院患儿中婴幼儿人群贫血原因,为防治婴幼儿贫血提供理论依据。方法对2010年8月1日~2013年8月30日在我科住院婴幼儿进行贫血调查,查找病因并进行随访。结果共224例婴幼儿完成随访。贫血病因以缺铁性病最常见(69.4%),但其中89.3%均为轻度表现,溶血性贫血次之,以蚕豆病为主,并有散发地中海贫血;因反复感染或伴随其它疾病的贫血占第3位。结论缺铁性贫血仍是婴幼儿贫血主要原因,有必要进一步加强对贫血防治工作。

  17. 224例住院婴幼儿贫血病因分析%Analysis of the Cause of Anemia in 224 Cases of Infants and Young Children

    杨俊杰

    2015-01-01

    目的探讨住院患儿中婴幼儿人群贫血原因,为防治婴幼儿贫血提供理论依据。方法对2010年8月1日~2013年8月30日在我科住院婴幼儿进行贫血调查,查找病因并进行随访。结果共224例婴幼儿完成随访。贫血病因以缺铁性病最常见(69.4%),但其中89.3%均为轻度表现,溶血性贫血次之,以蚕豆病为主,并有散发地中海贫血;因反复感染或伴随其它疾病的贫血占第3位。结论缺铁性贫血仍是婴幼儿贫血主要原因,有必要进一步加强对贫血防治工作。%Objective To study the hospitalized infants and young children crowd in children with anemia, provide theoretical basis for the prevention and treatment of anemia in infants. Methods On 2010.8.1~2010.8.30 hospitalized in our department infant anemia investigation, to find the cause and fol ow-up. Results A total of 224 cases of infants and young children to complete fol ow-up. The most common etiology anemia is iron deficiency disease (69.4%), but 89.3% of them are mild, hemolytic anemia take second place, with favism is given priority to, and send out the Mediter anean anemia; Because of the repeated infection or third of anemia with other diseases. Conclusion Iron deficiency anemia is stil the infant anemia main reason, it is necessary to further strengthen the anemia prevention and control work.

  18. The segregation of starless and protostellar clumps in the Hi-GAL l=224deg region

    Olmi, L; Elia, D; Jones, P

    2016-01-01

    Stars form in dense, dusty structures, which are embedded in larger clumps of molecular clouds often showing a clear filamentary structure on large scales (> 1pc). One of the best-studied regions in the Hi-GAL survey can be observed toward the l=224deg field. Here, a filamentary region has been studied and it has been found that protostellar clumps are mostly located along the main filament, whereas starless clumps are detected off this filament and are instead found on secondary, less prominent filaments. We want to investigate this segregation effect and how it may affect the clumps properties. We mapped the 12CO(1-0) line and its main three isotopologues toward the two most prominent filaments observed toward the l=224deg field using the Mopra radio telescope, in order to set observational constraints on the dynamics of these structures and the associated starless and protostellar clumps. Compared to the starless clumps, the protostellar clumps are more luminous, more turbulent and lie in regions where the...

  19. Microscopic study of positive-parity yrast bands of 224−234Th isotopes

    Daya Ram; Rani Devi; S K Khosa

    2013-06-01

    The positive-parity bands in 224−234Th are studied using the projected shell model (PSM) approach. The energy levels, deformation systematics, (2) transition probabilities and nuclear -factors are calculated and compared with the experimental data. The calculation reproduces the observed positive-parity yrast bands and (2) transition probabilities. Measurement of (2) transition probabilities for higher spins and -factors would be a stringent test for our predictions. The results of theoretical calculations indicate that the deformation systematics in 224−234Th isotopes depend on the occupation of low components of high j orbits in the valence space and the deformation producing tendency of the neutron–proton interaction operating between spin orbit partner (SOP) orbits, the $[(2g_{9/2}_{}) - (2g_{7/2})_{}]$ and $[(1i_{13/2})_{} - (1i_{11/2})_{}]$ SOP orbits in the present context. In addition, the deformation systematics also depend on the polarization of $(1h_{11/2})_{}$ orbit. The low-lying states of yrast spectra are found to arise from 0-quasiparticle (qp) intrinsic states whereas the high-spin states turn out to possess composite structure.

  20. Long term investigation of late effects in ankylosing spondylitis patients treated with radium-224

    Wick, R.R. [GSF - National Research Center for Environment and Health, Inst. of Radiobiology, Neuherberg (Germany); Nekolla, E.A. [Federal Office for Radiation Protection (BfS), Neuherberg (Germany)

    2005-07-01

    An epidemiological study has been carried out on 1462 ankylosing spondylitis (AS) patients followed since 1971 at the GSF - National Research Center for Environment and Health. The aim of the study was to ascertain the late health effects occurring in these patients who had received repeated intravenous injections of the short lived {alpha}-emitter {sup 224}radium between 1948 and 1975 (excluding patients treated additionally with X-rays). The then usual therapeutic protocol consisted of a total of 10 to 12 injections of 1.036 MBq (28 {mu}Ci) of {sup 224}Ra each, given at weekly intervals. This resulted in a cumulative {alpha}-dose of 0.56 to 0.67 Gy to the marrow-free skeleton (bone surface dose: {proportional_to} 5.5 Gy) of a 70-kg-man (standard man). These patients have been followed together with a control group of 1324 ankylosing spondylitis patients not treated with radioactive drugs and/or X-rays. Up to August 2004, causes of death have been ascertained for 913 exposed patients and 971 controls (mean follow-up time {proportional_to} 26 yr in the exposed group or {proportional_to} 24 yr in the control group). In the exposed group there has been a total of 251 malignant diseases (vs. 277.0 expected cases) and 233 cases (vs. 302.4 exp.) among the controls. In the exposure group 16 cases of kidney cancer (vs. 8.7 cases expected, p = 0.02), 6 cases of liver cancer (vs. 3.3 exp., p = 0.12), and 4 cases of thyroid cancer (vs. 1.1 exp., p = 0.03) were observed. The most striking observation, however, were the 16 cases of leukaemia in the exposure group (vs. 6.5 cases expected, p = 0.001) compared to only 10 cases of leukaemia in the control group (vs. 7.1 cases expected, p = 0.2). Further subclassification of the leukaemias demonstrated a high increase of myeloid leukaemia in the exposure group (10 cases obs. vs. 2.8 cases exp., p <0.001), and particularly, of myeloid leukaemia (7 cases observed vs. 1.7 expected, p = 0.002), whereas in the control group the number

  1. Long-term investigation of the risk of malignant diseases following intravenous radium-224 treatment for ankylosing spondylitis

    Background and purpose: in German-speaking countries, the intravenous treatment of ankylosing spondylitis (AS) with radium-224 (224Ra) was common between the late 1940s and 2005. In this long-term investigation, the risk of malignant diseases following intravenous 224Ra treatment for AS was assessed. Patients and methods: in a prospective long-term study, 1,471 patients with AS who were treated with 224Ra between 1948 and 1975 have been followed together with a control group of 1,324 AS patients treated neither with radioactive drugs nor with X-rays. Standardized questionnaires to evaluate the patients' health status were used. Observed numbers of malignant diseases were compared with those of the control group as well as with expected numbers for a normal population. Results: After 26 years of follow-up, causes of death have been certified for 1,006 patients of the exposure group (control group: 1,072 patients). Significantly increased rates of myeloid leukemia (12 cases observed vs. 2.9 expected; p 224Ra led to increased incidences of myeloid leukemia and malignancies of kidneys, thyroid and female genital organs. Although this kind of therapy is now abandoned, there is a need for close follow-up of patients who received it. (orig.)

  2. Comparison of estimated energy intake from 224-hour recalls and a seven-day food record with objective measurements of energy expenditure in children

    Rothausen, Berit Worm; Matthiessen, Jeppe; Groth, Margit Velsing;

    2012-01-01

    % limits of agreement were 438 and 3.52 MJ/d for the 224-HDRs, and 5.90 and 2.94 MJ/d for the 7-dFR. Pearson correlation coefficients between EI and EE were 0.51 for EI224-HDR and 0.29 for EI7-dFR, respectively. The proportion classified in the same or adjacent quartiles was 76% for EI224-HDR and 73% for...

  3. Synthesis, characterisation, stereochemistry and antimicrobial activity of 5 -piperazino- and 5-morpholinoacetyl-2,2,4-trimethyl-1, 5-benzodiazepines

    S Ponnuswamy; A Akila; D Deepa Rajakumari; V Shreevidhyaa Suressh; G Usha

    2015-11-01

    Three 1,5-benzodiazepines viz., 5-chloroacetyl-, 5-piperazinoacetyl- and N5 -morpholinoacetyl-2,2,4-trimethyl-1H-1,5-benzodiazepines have been synthesized. The structural characterisation and the conformational preferences of the compounds have been carried out using IR, 1D and 2D NMR spectral data. The NMR spectral data show that the -acetyltetrahydro-1,5-benzodiazepines prefer to exist in boat conformation with exo orientation of >C=O at 5 position in the solution state. The X-ray crystal structure of 5-morpholinoacetyl-2,2,4-trimethyl-1H-1,5-benzodiazepine also supports boat conformation in the solid state. The antimicrobial activity for -acetyltetrahydro-1,5-benzodiazepines have been carried out. -morpholinoacetyl-2,2,4-trimethyl-1H-1,5-benzodiazepine demonstrated better antibacterial and antifungal activities.

  4. Bis[2-(2,4-dinitrobenzylpyridinium] biphenyl-4,4′-disulfonate trihydrate

    Graham Smith

    2010-05-01

    Full Text Available In the structure of the title salt, 2C12H10N3O4+·C12H8O6S22−·3H2O, determined at 173 K, the biphenyl-4,4′-disulfonate dianions lie across crystallographic inversion centres with the sulfonate groups interacting head-to-head through centrosymmetric cyclic bis(water-bridged hydrogen-bonding associations [graph set R44(11], forming chains. The 2-(2,4-dinitrobenzylpyridinium cations are linked to these chains through pyridinium–water N—H...O hydrogen bonds and a two-dimensional network is formed through water bridges between sulfonate and 2-nitro O atoms, while the structure also has weak cation–anion π–π aromatic ring interactions [minimum ring centroid separation = 3.8441 (13 Å].

  5. Effect of shell structure on neutron multiplicity of fissioning systems 220,222,224Th nuclei

    Goyal Savi

    2015-01-01

    Full Text Available The pre- and post-scission neutron multiplicities have been extracted for the 220,222,224Th nuclei for the excitation energy range of 40 MeV to 64 MeV using the National Array of Neutron Detectors (NAND. The Th isotopes are populated from the fusion reaction of 16O+204,206,208Pb systems in order to investigate the dynamics of fusion-fission reactions using the neutron multiplicity as a probe. The theoretical calculations were performed using the Bohr-Wheeler fission width as well as the dissipative dynamical fission width from Kramers prescription. It is observed that the Bohr-Wheeler fission width underestimates the pre-scission yields to a large extent. A large amount of dissipation is required in the Kramers width to fit the observed pre-scission neutron multiplicities.

  6. Transient behavior of 2-(2',4'-dinitrobenzyl)pyridine photochromism studied by ultrafast laser spectroscopy

    Ultrafast transient behavior of photochromic 2-(2',4'-dinitrobenzyl)pyridine has been studied using femtosecond transient absorption spectroscopy. Three different transient signals could be found in the experiment at different time delays. The dynamics of transient behavior in the short time scale reveal that very fast relaxation (∼400 ± 100 fs) from the initial excited state leads to the formation of a relatively stable intermediate which is the precursor of proton transfer. The intermediate relaxes to the ground state of proton transferred aci-nitro structure in nanosecond time scale. The relatively slow proton transfer in DNBP is due to the necessity of extensive structural rearrangement before proton transfer. Solvent hydrogen bonding in ethanol seems to play an important role in the deactivation of the excited state giving entirely different photophysical behavior

  7. Oscillator strengths for Fe II transitions at 224.918 and 226.008 nanometers

    Bergeson, S. D.; Mullman, K. L.; Lawler, J. E.

    1994-01-01

    We report accurate experimental absorption oscillator strengths (f-values) for transitions out of the ground level of Fe II to the Z(sup 4)D(sup 0 sub 7/2) and z(sup 4)F(sup 0 sub 9/2) levels at 224.918 and 226.008 nm (air wavelengths) to be 0.00182(14) and 0.00244(19), respectively. The number in parenthesis is the uncertainty in the last digits. These two lines are important for studying Fe abundances and grain depletions in the interstellar medium. These f-values are determined by combining emission branching fractions with radiative lifetimes. Branching fractions are measured using classical spectroradiometry on an optically thin source. Radiative lifetimes are from the literature.

  8. Epidemiological assessment of lens opacifications that impaired vision in patients injected with radium-224

    The incidence of lens opacifications that impaired vision (cataract) was analyzed among 831 patients who were injected with known dosages of 224Ra in Germany shortly after World War II. The dependence of the incidence on dosage, i.e., injected activity per unit body weight, and on time after treatment was determined. The observations are equally consistent with proportionality of the incidence of cataract to the square of dosage or with a linear dependence beyond a threshold of 0.5 MBq/kg. The possibility of a linear dependence without threshold was strongly rejected (P less than 0.001). The analysis of temporal dependences yielded a component that was correlated with the injected amount of 224Ra and a component that was uncorrelated. The former was inferred by a maximum likelihood analysis to increase approximately as the square of the time after treatment. The component unrelated to the treatment was found to increase steeply with age and to become dominant within the collective of patients between age 50 and 60. The relative magnitudes of the two components were such that a fraction of 55 to 60% of the total of 58 cataracts had to be ascribed to the dose-related incidence. Impaired vision due to cataract was diagnosed before age 54 in 25 cases. In terms of injected activity per unit body weight no dependence of the sensitivity on age was found; specifically there was no indication of a faster occurrence of the treatment-related cataracts in patients treated at older ages

  9. Acute inhalation of 2,2,4-trimethylpentane alters visual evoked potentials and signal detection behaviour of rats.

    The volatile organic compound 2,2,4-trimethylpentane (TMP, “isooctane”) is a primary constituent of gasoline for which the current health effects data are insufficient to permit EPA to conduct a risk assessment. We evaluated potential neurological impairment from acute inhalati...

  10. Determination of 226Ra, 224Ra, 223Ra and 228Ra in mineral water samples of the Slovak Republic

    The Slovak Republic is very rich in mineral water sources. In recent years, it has been discovered that a number of mineral waters in the Slovak Republic contain high levels of 226Ra and 228Ra. Moreover, there is a lack of information on 224Ra and 223Ra concentrations in mineral waters as well. The currently approved techniques for alpha emitting radium isotopes are based on radon emanation methods. Due to the long ingrowth periods required by these techniques, any 224Ra and 223Ra in the sample decay away and go undetected. For this reason, we have used an alpha spectrometric method for the simultaneous determination of 226Ra, 223Ra and 224Ra. Radium was concentrated by a lead sulphate co-precipitation. The precipitate was dissolved in EDTA and the radium isotopes were separated from possible interfering radionuclides using barium sulphate micro precipitation. The radium-barium precipitate was filtered and counted by alpha spectrometry. 133Ba was used to quantify the yield by gamma spectrometry. In our laboratory, gamma spectrometry was also used for the determination of 228Ra in mineral water samples. Radium was concentrated by a lead-barium sulphate co-precipitation. 133Ba was used to quantify the yield, found to be 97 % on the average, by gamma spectrometry. Furthermore, the committed effective doses for 226Ra, 224Ra, 223Ra, 228Ra intake via ingestion of mineral waters for the members of public were calculated. (author)

  11. 25 CFR 224.116 - What is the time period in which the Director must investigate a tribe's compliance with a TERA?

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is the time period in which the Director must investigate a tribe's compliance with a TERA? 224.116 Section 224.116 Indians BUREAU OF INDIAN AFFAIRS... period in which the Director must investigate a tribe's compliance with a TERA? (a) If the...

  12. The properties of Hα emission-line galaxies at z = 2.24

    An, Fang Xia; Zheng, Xian Zhong [Purple Mountain Observatory, China Academy of Sciences, West Beijing Road 2, Nanjing 210008 (China); Wang, Wei-Hao [Academia Sinica Institute of Astronomy and Astrophysics, Taipei 10617, Taiwan (China); Huang, Jia-Sheng [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Kong, Xu; Wang, Jun-Xian; Zhu, Feifan [CAS Key Laboratory for Research in Galaxies and Cosmology, Department of Astronomy, University of Science and Technology of China, Hefei 230026 (China); Fang, Guan Wen [Institute for Astronomy and History of Science and Technology, Dali University, Yunnan 671003 (China); Gu, Qiu-Sheng [School of Astronomy and Space Science, Nanjing University, 22 Hankou RD, Nanjing 210093 (China); Wu, Hong [National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 (China); Hao, Lei [Shanghai Astronomical Observatory, Chinese Academy of Sciences, 80 Nandan Road, Shanghai 2000 30 (China); Xia, Xiao-Yang, E-mail: fangxiaan@pmo.ac.cn [Tianjin Astrophysics Center, Tianjin Normal University, Tianjin 300387 (China)

    2014-04-01

    Using deep narrowband H {sub 2} S1 and K {sub s}-band imaging data obtained with CFHT/WIRCam, we identify a sample of 56 Hα emission-line galaxies (ELGs) at z = 2.24 with the 5σ depths of H {sub 2} S1 = 22.8 and K {sub s} = 24.8 (AB) over a 383 arcmin{sup 2} area in the Extended Chandra Deep Field South. A detailed analysis is carried out with existing multi-wavelength data in this field. Three of the 56 Hα ELGs are detected in Chandra 4 Ms X-ray observations and two of them are classified as active galactic nuclei. The rest-frame UV and optical morphologies revealed by HST/ACS and WFC3 deep images show that nearly half of the Hα ELGs are either merging systems or have a close companion, indicating that the merging/interacting processes play a key role in regulating star formation at cosmic epoch z = 2-3. About 14% are too faint to be resolved in the rest-frame UV morphology due to high dust extinction. We estimate dust extinction from spectral energy distributions. We find that dust extinction is generally correlated with Hα luminosity and stellar mass. Our results suggest that Hα ELGs are representative of star-forming galaxies. Applying extinction corrections to individual objects, we examine the intrinsic Hα luminosity function (LF) at z = 2.24, obtaining a best-fit Schechter function characterized by a faint-end slope of α = – 1.3. This is shallower than the typical slope of α ≅ –1.6 in previous works based on constant extinction correction. We demonstrate that this difference is mainly due to the different extinction corrections. The proper extinction correction is thus the key to recovering the intrinsic LF as the extinction globally increases with Hα luminosity. Moreover, we find that our Hα LF mirrors the stellar mass function of star-forming galaxies at the same cosmic epoch. This finding indeed reflects the tight correlation between star formation rate and stellar mass for star-forming galaxies, i.e., the so-called main sequence.

  13. Determination of 226Ra and 224Ra in sediments samples by liquid scintillation counting

    An experimental procedure has been developed for a rapid determination of the activity concentration of 226Ra and 224Ra in sediments by liquid scintillation counting. The importance of the method lies in its application to the measurement of sediments where the Ra-isotopes activity concentration has been increased due to an anthropomorphic enhancement based on releases of naturally occurring radioactive material (NORM). A sample pre-treatment, including a digestion with aqua regia and a precipitation of hydroxides, was applied to samples before the radium extraction, which was made by co-precipitation with barium. Measurements were done in a low background scintillation spectrometer Quantulus 1220, which can separate and detect simultaneously α and β particles. Additionally, some improvements are suggested for a better α and β interference correction of the results. The obtaining of radiochemical yields is also improved using 133Ba as tracer, which decays by emission of conversion electrons and γ-rays; the wide range of radiochemical yields obtained confirms the need of this analyses. The procedure has been applied to the measurement of riverbed sediments from an estuary in the south-west of Spain, affected in the past by direct and indirect phosphogypsum discharges

  14. The Properties of H{\\alpha} Emission-Line Galaxies at $z$ = 2.24

    An, F X; Wang, W -H; Huang, J -S; Kong, X; Wang, J -X; Fang, G W; Zhu, F; Gu, Q -S; Wu, H; Hao, L; Xia, X -Y

    2014-01-01

    Using deep narrow-band $H_2S1$ and $K_{s}$-band imaging data obtained with CFHT/WIRCam, we identify a sample of 56 H$\\alpha$ emission-line galaxies (ELGs) at $z=2.24$ with the 5$\\sigma$ depths of $H_2S1=22.8$ and $K_{s}=24.8$ (AB) over 383 arcmin$^{2}$ area in the ECDFS. A detailed analysis is carried out with existing multi-wavelength data in this field. Three of the 56 H$\\alpha$ ELGs are detected in Chandra 4 Ms X-ray observation and two of them are classified as AGNs. The rest-frame UV and optical morphologies revealed by HST/ACS and WFC3 deep images show that nearly half of the H$\\alpha$ ELGs are either merging systems or with a close companion, indicating that the merging/interacting processes play a key role in regulating star formation at cosmic epoch z=2-3; About 14% are too faint to be resolved in the rest-frame UV morphology due to high dust extinction. We estimate dust extinction form SEDs. We find that dust extinction is generally correlated with H$\\alpha$ luminosity and stellar mass (SM). Our res...

  15. Lepton Flavor Violation within a realistic SO(10)/G(224) Framework

    Babu, K S; Rastogi, P K; Pati, Jogesh C.; Rastogi, Parul

    2005-01-01

    Lepton flavor violation (LFV) is studied within a realistic unified framework, based on supersymmetric SO(10) or an effective G(224) = SU(2)_L\\times SU(2)_R\\times SU(4)^c symmetry, that successfully describes (i) fermion masses and mixings, (ii) neutrino oscillations, as well as (iii) CP violation. LFV emerges as an important prediction of this framework, bringing no new parameters, barring the few SUSY parameters, which are assumed to be flavor-universal at M^*>= M_{GUT}. We study LFV (i.e. \\mu -> e\\gamma, \\tau -> \\mu\\gamma, \\tau -> e\\gamma and \\mu N -> e N) within this framework by including contributions both from the presence of the right handed neutrinos as well as those arising from renormalization group running in the post-GUT regime (M^* to M_{GUT}). Typically the latter, though commonly omitted in the literature, is found to dominate. Our predicted rates for \\mu -> e\\gamma show that while some choices of (m_o, m_{1/2}) are clearly excluded by the current empirical limit, this decay should be seen wit...

  16. Do nuclei go pear-shaped? Coulomb excitation of 220Rn and 224Ra at REX-ISOLDE (CERN

    Scheck M.

    2015-01-01

    Full Text Available The IS475 collaboration conducted Coulomb-excitation experiments with post-accelerated radioactive 220Rn and 224Ra beams at the REX-ISOLDE facility. The beam particles (Ebeam: 2.83 MeV/u were Coulomb excited using 60Ni, 114Cd, and 120Sn scattering targets. De-excitation γ-rays were detected employing the Miniball array and scattered particles were detected in a silicon detector. Exploiting the Coulomb-excitation code GOSIA for each nucleus several matrix elements could be obtained from the measured γ-ray yields. The extracted ‹3−||E3||0+› matrix element allows for the conclusion that, while 220Rn represents an octupole vibrational system, 224Ra has already substantial octupole correlations in its ground state. This finding has implications for the search of CP-violating Schiff moments in the atomic systems of the adjacent odd-mass nuclei.

  17. Investigation of $\\alpha$-decay rates of $^{221}$Fr, $^{224}$Ra and $^{226}$Ra in different environments

    2007-01-01

    It has recently been suggested, and indicated experimentally, that $\\alpha$- decay half-lives are modified by solid state effects in the surrounding environment. We propose here to measure with high accuracy the $\\alpha$-decay half-life of $^{221}$Fr, $^{224}$Ra and $^{226}$Ra in insulators and metals. Furthermore we plan to investigate the temperature dependency of the half-life in these materials (room temperature, 4 K and 10 mK).

  18. Long-term investigation of the risk of malignant diseases following intravenous radium-224 treatment for ankylosing spondylitis; Langzeituntersuchung zum Risiko maligner Erkrankungen nach intravenoeser Behandlung des Morbus Bechterew mit Radium-224

    Schulte, Tobias L. [Klinik und Poliklinik fuer Allgemeine Orthopaedie und Tumororthopaedie, Universitaetsklinikum Muenster (Germany); Nekolla, Elke A. [Bundesamt fuer Strahlenschutz (BfS), Neuherberg (Germany); Wick, Roland R. [Inst. fuer Strahlenbiologie, Helmholtz-Zentrum Muenchen, Deutsches Forschungszentrum fuer Gesundheit und Umwelt, Neuherberg (Germany)

    2009-09-15

    Background and purpose: in German-speaking countries, the intravenous treatment of ankylosing spondylitis (AS) with radium-224 ({sup 224}Ra) was common between the late 1940s and 2005. In this long-term investigation, the risk of malignant diseases following intravenous {sup 224}Ra treatment for AS was assessed. Patients and methods: in a prospective long-term study, 1,471 patients with AS who were treated with {sup 224}Ra between 1948 and 1975 have been followed together with a control group of 1,324 AS patients treated neither with radioactive drugs nor with X-rays. Standardized questionnaires to evaluate the patients' health status were used. Observed numbers of malignant diseases were compared with those of the control group as well as with expected numbers for a normal population. Results: After 26 years of follow-up, causes of death have been certified for 1,006 patients of the exposure group (control group: 1,072 patients). Significantly increased rates of myeloid leukemia (12 cases observed vs. 2.9 expected; p < 0.001), kidney cancer (18 vs. 9.1; p < 0.01), thyroid cancer (4 vs. 1.2; p = 0.03) and borderline significantly increased rates of cancer of female genital organs (10 vs. 5.6; p = 0.06) were found in the exposure group in contrast to no significant increases of these diseases in the control group. Rates of pulmonary and gastrointestinal malignancies were not increased. Lymphatic leukemia (exposure group: 8 vs. 2.7; p < 0.01; control group: 7 vs. 3; p = 0.03) was significantly elevated due to a high rate of chronic lymphatic leukemia in both, the exposure as well as the control group. Conclusion: treatment of AS with {sup 224}Ra led to increased incidences of myeloid leukemia and malignancies of kidneys, thyroid and female genital organs. Although this kind of therapy is now abandoned, there is a need for close follow-up of patients who received it. (orig.)

  19. The reverse protraction factor in the induction of bone sarcomas in radium-224 patients

    More than 50 bone sarcomas have occurred among a collective of about 800 patients who had been injected in Germany after World War II with large activities of radium-224 for the intended treatment of bone tuberculosis and ankylosing spondylitis. In an earlier analysis it was concluded that, at equal mean absorbed doses in the skeleton, patients with longer exposure time had a higher incidence of bone sarcomas. The previous analysis was based on approximations; in particular, it did not account for the varying times at risk of the individual patients. In view of the implications of a reverse protraction factor for basic considerations in radiation protection, the need was therefore felt to reevaluate the data from the continued follow-up by more rigorous statistical methods. A first step of the analysis demonstrates the existence of the reverse dose-rate effect in terms of a suitably constructed rank-order test. In a second step of the analysis it is concluded that the data are consistent with a linear no-threshold dose dependence under the condition of constant exposure time, while there is a steeper than linear dependence on dose when the exposure times increase proportionally to dose. A maximum likelihood fit of the data is then performed in terms of a proportional hazards model that includes the individual parameters, dose, treatment duration, and age at treatment. The fit indicates proportionality of the tumor rates to mean skeletal dose with an added factor (1 + 0.18.tau), where tau is the treatment time in months. This indicates that a protraction of the injections over 15 months instead of 5 months doubles the risk of bone sarcoma

  20. Study on the risk of late damage in humans after incorporation of the short-lived alpha emitter Ra-224; Studie zum Risiko von Spaetschaeden beim Menschen nach Inkorporation des kurzlebigen {alpha}-Strahlers Radium-224

    Wick, R.R.; Nekolla, E.A.; Kellerer, A.M. [Muenchen Univ. (Germany). Strahlenbiologisches Inst.; Goessner, W. [Gesellschaft fuer Strahlen- und Umweltforschung mbH Muenchen, Neuherberg (Germany). Inst. fuer Pathologie

    2003-07-01

    An epidemiological study has been carried out at the GSF - National Research Center for Environment and Health - between 1948 and 1975, on 1460 ankylosing spondylitis (AS) patients. The aim of the study was to ascertain the late health effects suffered by these patients who had received repeated intravenous injections of the short lived {alpha}-emitter {sup 224}Ra. These patients have been followed together with a control group of 1323 ankylosing spondylitis patients not treated with radioactive drugs and/or X-rays. Causes of death have been ascertained for 842 exposed patients and 861 controls by the end of 2002. In the exposed group there has been a total of 219 malignant diseases and 206 cases among the controls. In particular, we observed 15 cases of leukaemia in the exposure group and 8 cases of leukaemia in the control group. Further subclassification of the leukaemias demonstrated a high increase of myeloid leukaemia in the exposure group (9 cases obs. vs. 2.5 cases exp.), and out of these especially the acute myeloid leukaemias (6 cases observed vs. 1.6 expected), whereas in the control group the observed cases are within the expected range (3 myeloid leukaemias vs. 2.6 cases). Out of these 6 cases of myeloid leukaemia, 3 cases have been observed at doses comparable to those of the currently applied {sup 224}Ra treatment with the preparation SpondylAT {sup registered}, in one case the {sup 224}Ra-dose was the 0.6fold, in another case 1.6fold, whereas in one case the total dose could not be verified exactly. The enhanced leukaemia incidence in our exposed group is in line with results from animal experiments in mice having been injected with bone seeking {alpha}-emitters given at low dose rates. (orig.) [German] Im Rahmen einer epidemiologischen Studie werden im GSF-Forschungszentrum 1460 Bechterew-Patienten beobachtet, die in den Jahren 1948 bis 1975 zur Behandlung ihrer Krankheit wiederholte intravenoese Injektionen von {sup 224}Ra erhalten haben. Daneben

  1. 四川地区224例全血细胞减少症回顾性分析%Retrospective analysis on 224 cases of pancytopenia in Sichuan area

    杨银忠; 程文霞; 谢娜

    2014-01-01

    Objective To understand the etiopathogenesis of pancytopenia (PCP) in Sichuan area and to analyze the statistical difference in the aspects of sex ,season and age .Methods 224 cases of PCP were performed the etiological statistics on sex ,season and age by SPSS11 .0 .Results Among 224 cases of PCP ,46 cases(21% ) were megaloblastic anemia ,followed by 36 cases(16% ) of myelodysplastic syndromes (MDS) and 27 cases(12% ) of aplastic anemia(AA) .224 cases of PCP included 110 males(49 .10% ) and 114 females(50 .90% ) ,there was no statistical difference between sexes (P>0 .05) .In the seasons groups ,most of the patients went to see doctor and were diagnosed in the fourth quarter (32% ) and the first quarter was least (13% ) ,the difference between them had statistical significance(P<0 .05);In the age groups ,the age group of 45- <65 years old was the highest(36 .71% ) and the age group of less than 18 years was lowest(3 .57% ) ,the difference between them had statistical significance(P<0 .05) .Conclu-sion Megaloblastic anemia is the main etiology causing PCP in Sichuan area ,and the next is MDS and AA .The sex has no statisti-cal significance to the patients with PCP ,while the incidence rate in the aspects of season and age has statistical significance .%目的:了解四川地区全血细胞减少症(PC P )患者的病因,并分析其在性别、季度及年龄等方面有无统计学差异。方法对224例PC P患者进行病因统计,并按照性别、季度及年龄因素分组统计学分析。结果224例患者中,巨幼细胞性贫血最高占46例(21%),余依次骨髓增生异常综合征36例(16%),再生障碍性贫血27例(12%)等;224例患者中,男性110例(49.10%),女性114例(50.90%),两者比较差异无统计学意义( P>0.05);第4季度就医确诊患者最多(32%),第1季度最少(13%),两者比较差异有统计学意义( P<0.05);45~<65岁PC P

  2. Risk of leukaemia following intravenous treatment with {sup 224}Ra - results of a long term follow-up study of ankylosing spondylitis patients; Leukaemierisiko nach intravenoeser {sup 224}Ra-Behandlung - Ergebnisse einer Langzeitstudie an Bechterew-Patienten

    Wick, R.R. [GSF - Forschungszentrum fuer Umwelt und Gesundheit Neuherberg GmbH, Oberschleissheim (Germany). Inst. fuer Strahlenbiologie; Chmelevsky, D. [GSF - Forschungszentrum fuer Umwelt und Gesundheit Neuherberg GmbH, Oberschleissheim (Germany). Inst. fuer Strahlenschutz; Goessner, W. [GSF - Forschungszentrum fuer Umwelt und Gesundheit Neuherberg GmbH, Oberschleissheim (Germany). Inst. fuer Pathologie

    1993-12-31

    In an epidemiological study of the somatic late effects risk following incorporation of a short lived {alpha}-emitter, 1473 ankylosing spondylitis patients treated with repeated intravenous injections of {sup 224}Ra in the years 1948 - 75, have been observed in the GSF. The usual therapeutic plan consisted of a total of 10 - 12 injections of 1.036 MBq (28 {mu}Ci) of {sup 224}Ra each, given at weekly intervals; this would result in an cumulative {alpha}-dose of 0.56 - 0.67 Gy to the marrow-free skeleton of a 70-kg-man (standard man). These patients have been followed together with a control group of ankylosing spondylitis patients not treated with radioactive drugs and/or X-rays. Until May 1993 (mean follow-up time 19.9 yr), 595 patients of the exposure group and 722 patients of the control group have died, causes of death have been ascertained for 578, resp. 668 patients. Among others we observed in the exposure group 10 cases of leukaemia (vs. 2.7 - 2.8 cases expected, p < 0.001) and 6 cases of leukaemia in the control group (vs. 3.3 - 3.5 exp., p = 0.14). Subclassification of the leukaemias shows a clear preference for chronic myeloid leukaemia (CML) in the exposure group (4 cases obs. vs. 0.8 cases exp., p = 0.009), whereas in the control group the observed cases of CML are within the range of expectancy. Similar observations have not been made in another group of patients, now observed by Spiess and co-workers, who have been treated at a higher dose/dose rate range. This increased incidence of leukaemias in our exposure group is in one line with results from animal experiments with bone seeking {alpha}-emitters given at low dose rates. The induction of myeloid leukaemia has been demonstrated in mice down to dose rates of only a few mGy/day also for {sup 239}Pu, an {alpha}-emitter which like {sup 224}Ra deposits preferentially on the bone surface. (orig.) [Deutsch] Im Rahmen einer epidemiologischen Studie zum somatischen Strahlenspaetschadenrisiko nach

  3. Study on the risk of late damage in humans after incorporation of the short-lived alpha emitter Ra-224

    An epidemiological study has been carried out at the GSF - National Research Center for Environment and Health - between 1948 and 1975, on 1460 ankylosing spondylitis (AS) patients. The aim of the study was to ascertain the late health effects suffered by these patients who had received repeated intravenous injections of the short lived α-emitter 224Ra. These patients have been followed together with a control group of 1323 ankylosing spondylitis patients not treated with radioactive drugs and/or X-rays. Causes of death have been ascertained for 842 exposed patients and 861 controls by the end of 2002. In the exposed group there has been a total of 219 malignant diseases and 206 cases among the controls. In particular, we observed 15 cases of leukaemia in the exposure group and 8 cases of leukaemia in the control group. Further subclassification of the leukaemias demonstrated a high increase of myeloid leukaemia in the exposure group (9 cases obs. vs. 2.5 cases exp.), and out of these especially the acute myeloid leukaemias (6 cases observed vs. 1.6 expected), whereas in the control group the observed cases are within the expected range (3 myeloid leukaemias vs. 2.6 cases). Out of these 6 cases of myeloid leukaemia, 3 cases have been observed at doses comparable to those of the currently applied 224Ra treatment with the preparation SpondylAT registered, in one case the 224Ra-dose was the 0.6fold, in another case 1.6fold, whereas in one case the total dose could not be verified exactly. The enhanced leukaemia incidence in our exposed group is in line with results from animal experiments in mice having been injected with bone seeking α-emitters given at low dose rates. (orig.)

  4. Measurements of octupole collectivity in $^{220,222}$Rn and $^{222,224}$Ra using Coulomb excitation

    Kruecken, R; Larsen, A; Hurst, A M; Voulot, D; Grahn, T; Clement, E; Wadsworth, R; Gernhaeuser, R A; Siem, S; Huyse, M L; Iwanicki, J S

    2008-01-01

    We propose to exploit the unique capability of ISOLDE to provide post-accelerated $^{220,222}$Rn and $^{222,224}$Ra ion beams from the REX facility to enable the Coulomb excitation of the first 3$^{-}$ states in these nuclei. By measuring the $\\gamma$-ray yields of the E1 decays from the 3$^{-}$ state using the MINIBALL array we can obtain the transition matrix elements. This will give quantitative information about octupole correlations in these nuclei. We require 22 shifts to fulfil the aims of the experiment.

  5. Comparison of the action of radium 224 and other radioactive elements in the treatment of rheumatoid arthritis

    The authors compared 5 radionuclides used in radiosynoviorthesis for the treatment of rheumatic polyarthritis. The excretion after injection into the knee-joints of a number of patient was studied. It was found that only colloidal solutions should be used, and that α and β sources are not effective enough. The chloride of the isotope 224Ra was less effective than the corresponding 198Au, 169Er, 90Y, and 186Re compounds. The clinical findings in more than 450 cases confirm these assumptions. (MG)

  6. Crystal structure of ethyl 2-(1H-benzimidazol-2-yl-2-[2-(4-nitrophenylhydrazinylidene]acetate

    Mohamed Loughzail

    2015-04-01

    Full Text Available The title compound, C17H15N5O4, was obtained via the condensation of 3-ethoxy-2-[2-(4-nitrophenylhydrazono]-3-oxopropanoic acid with 1,2-diaminobenzene. In the molecule, the dihedral angles between the acetate group and the two aromatic subunits (benzimidazole and nitrophenylhydrazone are 7.35 (9 and 18.23 (9°, respectively. Intramolecular N—H...O and N—H...N contacts occur. In the crystal, C—H...O and N—H...O hydrogen bonds link the molecules into chains along the b-axis direction.

  7. Influence of Neutron Shell Closure (Nc=126) on Prescission Particle Emission of Fissioning Systems 216,224Th

    叶巍

    2003-01-01

    The effect of neutron shell closure Nc = 126 on the prescission-particle emission of 216Th and 224Th nuclei is investigated within the framework of an extensive Smoluchowski equation. It is found that there is a large difference in the prescission neutron multiplicity for the two Th nuclei, indicating a strong shell effect in neutron emission. Moreover, shell effects on particle emission are also investigated as functions of excitation energy,angular momentum and nuclear viscosity. The results show that with increasing excitation energy shell effects in prefission neutron evolve from continual strength to gradual weakness. Both high angular momenta and low viscosity weaken the shell effects on the particle emission.

  8. Observation of Antibacterial Activity of Minocycline Against 224 Strains of Enterococci in vitro%米诺环素对224株肠球菌的体外抗菌活性研究

    李仲兴; 王秀华; 杨敬芳; 时东彦; 李玮; 李继红

    2005-01-01

    目的:考察米诺环素对224株肠球菌的体外抗菌活性.方法:用二倍琼脂稀释法对224株肠球菌进行体外抗菌实验,并与多西环素、替考拉宁、万古霉素等进行抗菌效果对比.结果:米诺环素对169株粪肠球菌和51株屎肠球菌的MIC90分别为4和2μg·ml-1,而多西环素对169株粪肠球菌和51株屎肠球菌的MIC90则分别为4和4μg·ml-1.结论:米诺环素对肠球菌的抗菌效果与多西环素相似.

  9. MicroRNA-224 is Readily Detectable in Urine of Individuals with Diabetes Mellitus and is a Potential Indicator of Beta-Cell Demise

    Siobhán Bacon

    2015-06-01

    Full Text Available MicroRNA (miRNA are a class of non-coding, 19–25 nucleotide RNA critical for network-level regulation of gene expression. miRNA serve as paracrine signaling molecules. Using an unbiased array approach, we previously identified elevated levels of miR-224 and miR-103 to be associated with a monogenic form of diabetes; HNF1A-MODY. miR-224 is a novel miRNA in the field of diabetes. We sought to explore the role of miR-224 as a potential biomarker in diabetes, and whether such diabetes-associated-miRNA can also be detected in the urine of patients. Absolute levels of miR-224 and miR-103 were determined in the urine of n = 144 individuals including carriers of a HNF1A mutation, participants with type 1 diabetes mellitus (T1DM, type 2 diabetes mellitus (T2DM and normal controls. Expression levels were correlated with clinical and biochemical parameters. miR-224 was significantly elevated in the urine of carriers of a HNF1A mutation and participants with T1DM. miR-103 was highly expressed in urine across all diabetes cohorts when compared to controls. For both miR-224 and-103, we found a significant correlation between serum and urine levels (p < 0.01. We demonstrate that miRNA can be readily detected in the urine independent of clinical indices of renal dysfunction. We surmise that the differential expression levels of miR-224 in both HNF1A-MODY mutation carriers and T1DM may be an attempt to compensate for beta-cell demise.

  10. Purification, crystallization and preliminary crystallographic characterization of the α2,6-sialyltransferase from Photobacterium sp. JT-ISH-224

    Okino, Nozomu; Kakuta, Yoshimitsu, E-mail: kakuta@agr.kyushu-u.ac.jp [Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581 (Japan); Kajiwara, Hitomi; Ichikawa, Masako; Takakura, Yoshimitsu [Glycotechnology Business Unit, Japan Tobacco Inc., 700 Higashibara, Iwata, Shizuoka 438-0802 (Japan); Ito, Makoto [Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581 (Japan); Yamamoto, Takeshi, E-mail: kakuta@agr.kyushu-u.ac.jp [Glycotechnology Business Unit, Japan Tobacco Inc., 700 Higashibara, Iwata, Shizuoka 438-0802 (Japan); Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581 (Japan)

    2007-08-01

    Crystallization of the α2,6-sialyltransferase from Photobacterium. Sialyltransferases transfer sialic acid from cytidine-5-monophospho-N-acetylneuraminic acid (CMP-NeuAc) to the nonreducing termini of the oligosaccharyl structures of various glycoproteins and glycolipids. The newly cloned α2,6-sialyltransferase from Photobacterium sp. JT-ISH-224 (from the Vibrionaceae family) is composed of two domains: an unknown N-terminal domain and a catalytic C-terminal domain which shares significant homology with the Pasteurella multocida multifunctional sialyltransferase. The putative mature form of JT-ISH-224 α2,6-sialyltransferase was overproduced in Escherichia coli, purified and crystallized using the hanging-drop vapour-diffusion method at 293 K. The crystal belonged to space group P3{sub 1}21 or P3{sub 2}21, with unit-cell parameters a = b = 90.29, c = 204.33 Å. X-ray diffraction data were collected to 2.5 Å resolution.

  11. Determination of Ra-224, Ra-226 and Ra-228 by gamma-ray spectrometry with radon retention

    Full text: The purpose of this work is to improve the determination, through gamma-ray spectrometry, of radium isotopes 228Ra, 226Ra and 224Ra in water. This improvement has been developed after the participation in the IAEA Proficiency test: 'Determination of radium and Uranium radionuclides in water' in December 2002, and applied to the same samples of this proficiency test. The aim of this new procedure is the determination of 228Ra, 226Ra and 224Ra activities by measuring the gamma-ray emissions of their decay products 228Ac, 214Pb and 212Pb, respectively. In the search for these activities, radiochemical separation of radium and lead are required. A coprecipitation method with stable barium and lead was carried out to obtain two different precipitates, both of them as sulphate. However emanation of unknown quantities of 222Rn and 220Rn is produced from the fine precipitate of the radium sulphate obtained which leads to wrong determinations of 224Ra and 226Ra activities. To avoid this radon exhalation effect the mentioned deposit, once the chemical yield has been calculated, is dissolved with EDTA and the resulting liquid incorporated into charcoal, and then it is dried and introduced into a suitable container. Afterwards the container is sealed and stored in a freezer. Different configurations of charcoal sizes and types as well as containers have been analysed. To perform this analysis several samples of those mentioned above containing 226Ra were used in order to test its equilibrium with the progeny, 214Pb and 214Bi, through gamma-ray spectrometry. The following results for contaminated samples with less than 50 Bq of 226Ra and using 30 ∼ 50 g of charcoal have been obtained: 1) There is a slight tendency to obtain better results using metallic containers rather than plastic ones 2) In general, specific activated charcoals, prepared to retain radon or noble gases allow better results than unspecific charcoals, but cannot be considered as better in a clear

  12. Oral health education to 224 cases of pregnancy women's oral health impact study%口腔健康教育对224例妊娠期妇女口腔健康影响研究

    胡芳; 李健; 万燕燕

    2013-01-01

    Objective:To explore oral health education effect on pregnancy women's oral health.methods:224 patients were randomly divided into the treatment group 224 examples (for oral health education in patients with pregnancy) and the control group, 114 cases of oral health education (no). Observe two groups of pregnancy women's oral health.results:110 cases of late pregnancy women after oral health education during pregnancy gingivitis incidence of 3.63%, 1.81%incidence of tooth decay, periodontal disease incidence of 1.81%, wisdom tooth pericoronitis incidence of 2.72%. The total incidence of 10%.conclusion:Oral health education for women during pregnancy gingivitis and dental caries, periodontal disease, wisdom tooth pericoronitis incidence decreased significantly. Oral health education should pay more at ention to pregnant women.%目的:探讨口腔健康教育对妊娠期妇女口腔健康影响。方法:224例患者随机分为治疗组110例(对妊娠期患者进行口腔健康教育)与对照组114例(没有进行口腔健康教育)。观察两组妊娠期妇女口腔健康状况。结果:110例妊娠期妇女经过口腔健康教育后妊娠后期龈炎发病率3.63%,龋病发病率1.81%,牙周病发病率1.81%,智齿冠周炎发病率2.72%。总发病率10%。结论:口腔健康教育对妊娠期妇女牙龈炎、龋齿、牙周病、智齿冠周炎的发病率显著降低。孕妇口腔健康教育应当更加重视。

  13. Onset of pi(0) suppression studied in Cu+Cu collisions at sqrt S NN=22.4, 62.4, and 200 GeV.

    Adare, A; Afanasiev, S; Aidala, C; Ajitanand, N N; Akiba, Y; Al-Bataineh, H; Alexander, J; Aoki, K; Aphecetche, L; Armendariz, R; Aronson, S H; Asai, J; Atomssa, E T; Averbeck, R; Awes, T C; Azmoun, B; Babintsev, V; Bai, M; Baksay, G; Baksay, L; Baldisseri, A; Barish, K N; Barnes, P D; Bassalleck, B; Basye, A T; Bathe, S; Batsouli, S; Baublis, V; Baumann, C; Bazilevsky, A; Belikov, S; Bennett, R; Berdnikov, A; Berdnikov, Y; Bickley, A A; Boissevain, J G; Borel, H; Boyle, K; Brooks, M L; Buesching, H; Bumazhnov, V; Bunce, G; Butsyk, S; Camacho, C M; Campbell, S; Chang, B S; Chang, W C; Charvet, J-L; Chernichenko, S; Chiba, J; Chi, C Y; Chiu, M; Choi, I J; Choudhury, R K; Chujo, T; Chung, P; Churyn, A; Cianciolo, V; Citron, Z; Cleven, C R; Cole, B A; Comets, M P; Constantin, P; Csanád, M; Csörgo, T; Dahms, T; Dairaku, S; Das, K; David, G; Deaton, M B; Dehmelt, K; Delagrange, H; Denisov, A; d'Enterria, D; Deshpande, A; Desmond, E J; Dietzsch, O; Dion, A; Donadelli, M; Drapier, O; Drees, A; Drees, K A; Dubey, A K; Durum, A; Dutta, D; Dzhordzhadze, V; Efremenko, Y V; Egdemir, J; Ellinghaus, F; Emam, W S; Engelmore, T; Enokizono, A; En'yo, H; Esumi, S; Eyser, K O; Fadem, B; Fields, D E; Finger, M; Finger, M; Fleuret, F; Fokin, S L; Fraenkel, Z; Frantz, J E; Franz, A; Frawley, A D; Fujiwara, K; Fukao, Y; Fusayasu, T; Gadrat, S; Garishvili, I; Glenn, A; Gong, H; Gonin, M; Gosset, J; Goto, Y; Granier de Cassagnac, R; Grau, N; Greene, S V; Grosse Perdekamp, M; Gunji, T; Gustafsson, H-A; Hachiya, T; Hadj Henni, A; Haegemann, C; Haggerty, J S; Hamagaki, H; Han, R; Harada, H; Hartouni, E P; Haruna, K; Haslum, E; Hayano, R; Heffner, M; Hemmick, T K; Hester, T; He, X; Hiejima, H; Hill, J C; Hobbs, R; Hohlmann, M; Holzmann, W; Homma, K; Hong, B; Horaguchi, T; Hornback, D; Huang, S; Ichihara, T; Ichimiya, R; Ikeda, Y; Imai, K; Imrek, J; Inaba, M; Inoue, Y; Isenhower, D; Isenhower, L; Ishihara, M; Isobe, T; Issah, M; Isupov, A; Ivanischev, D; Jacak, B V; Jia, J; Jin, J; Jinnouchi, O; Johnson, B M; Joo, K S; Jouan, D; Kajihara, F; Kametani, S; Kamihara, N; Kamin, J; Kaneta, M; Kang, J H; Kanou, H; Kapustinsky, J; Kawall, D; Kazantsev, A V; Kempel, T; Khanzadeev, A; Kijima, K M; Kikuchi, J; Kim, B I; Kim, D H; Kim, D J; Kim, E; Kim, S H; Kinney, E; Kiriluk, K; Kiss, A; Kistenev, E; Kiyomichi, A; Klay, J; Klein-Boesing, C; Kochenda, L; Kochetkov, V; Komkov, B; Konno, M; Koster, J; Kotchetkov, D; Kozlov, A; Král, A; Kravitz, A; Kubart, J; Kunde, G J; Kurihara, N; Kurita, K; Kurosawa, M; Kweon, M J; Kwon, Y; Kyle, G S; Lacey, R; Lai, Y-S; Lai, Y S; Lajoie, J G; Layton, D; Lebedev, A; Lee, D M; Lee, K B; Lee, M K; Lee, T; Leitch, M J; Leite, M A L; Lenzi, B; Liebing, P; Liska, T; Litvinenko, A; Liu, H; Liu, M X; Li, X; Love, B; Lynch, D; Maguire, C F; Makdisi, Y I; Malakhov, A; Malik, M D; Manko, V I; Mannel, E; Mao, Y; Masek, L; Masui, H; Matathias, F; McCumber, M; McGaughey, P L; Means, N; Meredith, B; Miake, Y; Mikes, P; Miki, K; Miller, T E; Milov, A; Mioduszewski, S; Mishra, M; Mitchell, J T; Mitrovski, M; Mohanty, A K; Morino, Y; Morreale, A; Morrison, D P; Moukhanova, T V; Mukhopadhyay, D; Murata, J; Nagamiya, S; Nagata, Y; Nagle, J L; Naglis, M; Nagy, M I; Nakagawa, I; Nakamiya, Y; Nakamura, T; Nakano, K; Newby, J; Nguyen, M; Niita, T; Norman, B E; Nouicer, R; Nyanin, A S; O'Brien, E; Oda, S X; Ogilvie, C A; Ohnishi, H; Okada, H; Okada, K; Oka, M; Omiwade, O O; Onuki, Y; Oskarsson, A; Ouchida, M; Ozawa, K; Pak, R; Pal, D; Palounek, A P T; Pantuev, V; Papavassiliou, V; Park, J; Park, W J; Pate, S F; Pei, H; Peng, J-C; Pereira, H; Peresedov, V; Peressounko, D Yu; Pinkenburg, C; Purschke, M L; Purwar, A K; Qu, H; Rak, J; Rakotozafindrabe, A; Ravinovich, I; Read, K F; Rembeczki, S; Reuter, M; Reygers, K; Riabov, V; Riabov, Y; Roach, D; Roche, G; Rolnick, S D; Romana, A; Rosati, M; Rosendahl, S S E; Rosnet, P; Rukoyatkin, P; Ruzicka, P; Rykov, V L; Sahlmueller, B; Saito, N; Sakaguchi, T; Sakai, S; Sakashita, K; Sakata, H; Samsonov, V; Sato, S; Sato, T; Sawada, S; Sedgwick, K; Seele, J; Seidl, R; Semenov, A Yu; Semenov, V; Seto, R; Sharma, D; Shein, I; Shevel, A; Shibata, T-A; Shigaki, K; Shimomura, M; Shoji, K; Shukla, P; Sickles, A; Silva, C L; Silvermyr, D; Silvestre, C; Sim, K S; Singh, B K; Singh, C P; Singh, V; Skutnik, S; Slunecka, M; Soldatov, A; Soltz, R A; Sondheim, W E; Sorensen, S P; Sourikova, I V; Staley, F; Stankus, P W; Stenlund, E; Stepanov, M; Ster, A; Stoll, S P; Sugitate, T; Suire, C; Sukhanov, A; Sziklai, J; Tabaru, T; Takagi, S; Takagui, E M; Taketani, A; Tanabe, R; Tanaka, Y; Tanida, K; Tannenbaum, M J; Taranenko, A; Tarján, P; Themann, H; Thomas, T L; Togawa, M; Toia, A; Tojo, J; Tomásek, L; Tomita, Y; Torii, H; Towell, R S; Tram, V-N; Tserruya, I; Tsuchimoto, Y; Vale, C; Valle, H; vanHecke, H W; Veicht, A; Velkovska, J; Vertesi, R; Vinogradov, A A; Virius, M; Vrba, V; Vznuzdaev, E; Wagner, M; Walker, D; Wang, X R; Watanabe, Y; Wei, F; Wessels, J; White, S N; Winter, D; Woody, C L; Wysocki, M; Xie, W; Yamaguchi, Y L; Yamaura, K; Yang, R; Yanovich, A; Yasin, Z; Ying, J; Yokkaichi, S; Young, G R; Younus, I; Yushmanov, I E; Zajc, W A; Zaudtke, O; Zhang, C; Zhou, S; Zimányi, J; Zolin, L

    2008-10-17

    Neutral pion transverse momentum (p(T)) spectra at midrapidity (|y| less than or approximately 0.35) were measured in Cu+Cu collisions at sqrt[s(NN)]=22.4, 62.4, and 200 GeV. Relative to pi_(0) yields in p+p collisions scaled by the number of inelastic nucleon-nucleon collisions (N(coll) the pi_(0) yields for p(T) more than or approximately 2 GeV/c in central Cu+Cu collisions are suppressed at 62.4 and 200 GeV whereas an enhancement is observed at 22.4 GeV. A comparison with a jet-quenching model suggests that final state parton energy loss dominates in central Cu+Cu collisions at 62.4 and 200 GeV, while the enhancement at 22.4 GeV is consistent with nuclear modifications in the initial state alone. PMID:18999660

  14. Energy dependence of pi-zero production in Cu+Cu collisions at sqrt(s_NN) = 22.4, 62.4, and 200 GeV

    Adare, A; Aidala, C; Ajitanand, N N; Akiba, Y; Al-Bataineh, H; Alexander, J; Aoki, K; Aphecetche, L; Armendariz, R; Aronson, S H; Asai, J; Atomssa, E T; Averbeck, R; Awes, T C; Azmoun, B; Babintsev, V; Bai, M; Baksay, G; Baksay, L; Baldisseri, Alberto; Barish, K N; Barnes, P D; Bassalleck, B; Basye, A T; Bathe, S; Batsouli, S; Baublis, V; Baumann, C; Bazilevsky, A; Belikov, S; Bennett, R; Berdnikov, A; Berdnikov, Y; Bickley, A A; Boissevain, J G; Borel, H; Boyle, K; Brooks, M L; Büsching, H; Bumazhnov, V; Bunce, G; Butsyk, S; Camacho, C M; Campbell, S; Chang, B S; Chang, W C; Charvet, J L; Chernichenko, S; Chiba, J; Chi, C Y; Chiu, M; Choi, I J; Choudhury, R K; Chujo, T; Chung, P; Churyn, A; Cianciolo, V; Citron, Z; Cleven, C R; Cole, B A; Comets, M P; Constantin, P; Csanad, M; Csrgo, T; Dahms, T; Dairaku, S; Das, K; Dávid, G; Deaton, M B; Dehmelt, K; Delagrange, H; Denisov, A; d'Enterria, D; Deshpande, A; Desmond, E J; Dietzsch, O; Dion, A; Donadelli, M; Drapier, O; Drees, A; Drees, K A; Dubey, A K; Durum, A; Dutta, D; Dzhordzhadze, V; Efremenko, Yu V; Egdemir, J; Ellinghaus, F; Emam, W S; Engelmore, T; Enokizono, A; Enyo, H; Esumi, S; Eyser, K O; Fadem, B; Fields, D E; Finger, M; Finger, M; Fleuret, F; Fokin, S L; Fraenkel, Zeev; Frantz, J E; Franz, A; Frawley, A D; Fujiwara, K; Fukao, Y; Fusayasu, T; Gadrat, S; Garishvili, I; Glenn, A; Gong, H; Gonin, M; Gosset, J; Goto, Y; Granier de Cassagnac, R; Grau, N; Greene, S V; Grosse-Perdekamp, M; Gunji, T; Gustafsson, H; Hachiya, T; Hadj Henni, A; Haegemann, C; Haggerty, J S; Hamagaki, H; Han, AR; Harada, H; Hartouni, E P; Haruna, K; Haslum, E; Hayano, R; Heffner, M; Hemmick, T K; Hester, T; He, X; Hiejima, H; Hill, J C; Hobbs, R; Hohlmann, M; Holzmann, W; Homma, K; Hong, B; Horaguchi, T; Hornback, D; Huang, S; Ichihara, T; Ichimiya, R; Ikeda, Y; Imai, K; Imrek, J; Inaba, M; Inoue, Y; Isenhower, D; Isenhower, L; Ishihara, M; Isobe, T; Issah, M; Isupov, A; Ivanischev, D; Jacak, B V; Jia, J; Jin, J; Jinnouchi, O; Johnson, B M; Joo, K S; Jouan, D; Kajihara, F; Kametani, S; Kamihara, N; Kamin, J; Kaneta, M; Kang, J H; Kanou, H; Kapustinsky, J; Kawall, D; Kazantsev, A V; Khanzadeev, A; Kijima, K M; Kikuchi, J; Kim, B I; Kim, D H; Kim, D J; Kim, E; Kim, S H; Kinney, E; Kiriluk, K; Kiss, A; Kistenev, E; Kiyomichi, A; Klay, J; Klein-Bösing, C; Kochenda, L; Kochetkov, V; Komkov, B; Konno, M; Koster, J; Kotchetkov, D; Kozlov, A; Krl, A; Kravitz, A; Kubart, J; Kunde, G J; Kurihara, N; Kurita, K; Kurosawa, M; Kweon, M J; Kwon, Y; Kyle, G S; Lacey, R; Lai, Y S; Lai, Y S; Lajoie, J G; Layton, D; Lebedev, A; Lee, D M; Lee, K B; Lee, M K; Lee, T; Leitch, M J; Leite, M A L; Lenzi, B; Liebing, P; Lika, T; Litvinenko, A; Liu, H; Liu, M X; Li, X; Love, B; Lynch, D; Maguire, C F; Makdisi, Y I; Malakhov, A; Malik, M D; Man'ko, V I; Mannel, E; Mao, Y; Maek, L; Masui, H; Matathias, F; McCumber, M; McGaughey, P L; Means, N; Meredith, B; Miake, Y; Mike, P; Miki, K; Miller, T E; Milov, A; Mioduszewski, S; Mishra, M; Mitchell, J T; Mitrovski, M; Mohanty, A K; Morino, Y; Morreale, A; Morrison, D P; Moukhanova, T V; Mukhopadhyay, D; Murata, J; Nagamiya, S; Nagata, Y; Nagle, J L; Naglis, M; Nagy, M I; Nakagawa, I; Nakamiya, Y; Nakamura, T; Nakano, K; Newby, J; Nguyen, M; Niita, T; Norman, B E; Nouicer, R; Nyanin, A S; O'Brien, E; Oda, S X; Ogilvie, C A; Ohnishi, H; Okada, H; Okada, K; Oka, M; Omiwade, O O; Onuki, Y; Oskarsson, A; Ouchida, M; Ozawa, K; Pak, R; Pal, D; Palounek, A P T; Pantuev, V; Papavassiliou, V; Park, J; Park, W J; Pate, S F; Pei, H; Peng, J C; Pereira, H; Peresedov, V; Peressounko, D Yu; Pinkenburg, C; Purschke, M L; Purwar, A K; Qu, H; Rak, J; Rakotozafindrabe, A; Ravinovich, I; Read, K F; Rembeczki, S; Reuter, M; Reygers, K; Riabov, V; Riabov, Y; Roach, D; Roche, G; Rolnick, S D; Romana, A; Rosati, M; Rosendahl, S S E; Rosnet, P; Rukoyatkin, P; Ruika, P; Rykov, V L; Sahlmueller, B; Saitô, N; Sakaguchi, T; Sakai, S; Sakashita, K; Sakata, H; Samsonov, V; Sato, S; Sato, T; Sawada, S; Sedgwick, K; Seele, J; Seidl, R; Semenov, A Yu; Semenov, V; Seto, R; Sharma, D; Shein, I; Shevel, A; Shibata, T A; Shigaki, K; Shimomura, M; Shoji, K; Shukla, P; Sickles, A; Silva, C L; Silvermyr, D; Silvestre, C; Sim, K S; Singh, B K; Singh, C P; Singh, V; Skutnik, S; Sluneka, M; Soldatov, A; Soltz, R A; Sondheim, W E; Sørensen, S P; Sourikova, I V; Staley, F; Stankus, P W; Stenlund, E; Stepanov, M; Ster, A; Stoll, S P; Sugitate, T; Suire, C; Sukhanov, A; Sziklai, J; Tabaru, T; Takagi, S; Takagui, E M; Taketani, A; Tanabe, R; Tanaka, Y; Tanida, K; Tannenbaum, M J; Taranenko, A; Tarjn, P; Themann, H; Thomas, T L; Togawa, M; Toia, A; Tojo, J; Tomaek, L; Tomita, Y; Torii, H; Towell, R S; Tram, V-N; Tserruya, Itzhak; Tsuchimoto, Y; Vale, C; Valle, H; van Hecke, H W; Veicht, A; Velkovska, J; Vertesi, R; Vinogradov, A A; Virius, M; Vrba, V; Vznuzdaev, E; Wagner, M; Walker, D; Wang, X R; Watanabe, Y; Wei, F; Wessels, J; White, S N; Winter, D; Woody, C L; Wysocki, M; Xie, W; Yamaguchi, Y L; Yamaura, K; Yang, R; Yanovich, A; Yasin, Z; Ying, J; Yokkaichi, S; Young, G R; Younus, I; Yushmanov, I E; Zajc, W A; Zaudtke, O; Zhang, C; Zhou, S; Zimányi, J; Zolin, L

    2008-01-01

    Neutral pion transverse momentum (pT) spectra at mid-rapidity (|y| < 0.35) were measured in Cu+Cu collisions at \\sqrt s_NN = 22.4, 62.4, and 200 GeV. Relative to pi -zero yields in p+p collisions scaled by the number of inelastic nucleon-nucleon collisions (Ncoll) at the respective energies, the pi-zero yields for pT \\ge 2 GeV/c in central Cu+Cu collisions at 62.4 and 200 GeV are suppressed, whereas an enhancement is observed at 22.4 GeV. A comparison with a jet quenching model suggests that final state parton energy loss dominates in central Cu+Cu collisions at 62.4 GeV and 200 GeV, while the enhancement at 22.4 GeV is consistent with nuclear modifications in the initial state alone.

  15. EFSA Panel on Food Contact Materials , Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 224 (FGE.224): Consideration of genotoxic potential for two α,β - unsaturated thiophenes from subgroup 5.2 of FGE.19 by EFSA

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Lund, Pia; Nørby, Karin Kristiane

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of two flavouring substances from subgroup 5.2 of FGE.19 in the Flavouring Group Evaluation 224 (FGE.224). The Flavour Industry has...... are still pending and no conclusion could be drawn in the present FGE. © European Food Safety Authority, 2013......The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of two flavouring substances from subgroup 5.2 of FGE.19 in the Flavouring Group Evaluation 224 (FGE.224). The Flavour Industry has...... provided additional genotoxicity studies for one of the two substances in FGE.224, namely 5-methyl-2-thiophenecarbaldehyde [FL-no: 15.004]. The data requested by EFSA for the other substance, 3-acetyl-2,5-dimethylthiophene [FL-no: 15.024] of FGE.224 will be provided subsequently according to the Flavour...

  16. Experimental experiences with intra-articular injections of the α-emitting radionuclide 224Ra(ThX) into the knee-joint of rats

    224Ra is used within the therapy of rheumatoid arthritis. The distribution of this radionuclide in the organism was investigated up to 7 days after incorporation in order to estimate a possible risk of late effects. In the autoradiographs we found strong blackenings at those bonesurfaces which faced the injected knee-joint hole. In addition the radionuclide was deposited in skeletal growth-zones similarly as after i.v. and i.p. injections. The dosimetric data (particularly of knee-joint and skeleton) were calculated and compared with those which occur after the therapy of ankylosing spondylitis using i.v. 224Ra injections. (orig.)

  17. Activation of endogenous C-type retroviral genomes by internal alpha-irradiation of mice with 224Radium

    Sensitive cocultivation techniques were applied to study the radiation-induced activation of endogenous retroviral genomes in different mouse strains by the alpha-emitting radionuclide 224Radium. Activated infectious C-type retroviruses were detected in spleen, bone marrow and bone tissues of C57BL/6-, BALB/c- and NMRI mice. The titres of high-dose-irradiated animals were higher than those found in low-dose-irradiated animals. Infectious retrovirus could be detected with a dose of 13.2 rad (maximum dose rate 0.9 rad/day) in the skeleton, and a dose of 4.2 rad (maximum dose rate 0.3 rad/day) in the spleen. The virus activation pattern was different in the three mouse strains. These data indicate that activation of endogenous retroviral genomes by alpha-irradiation shows a dose-effect relationship and a dependence on the genetic background of the mouse. (orig.)

  18. Study of the reaction anti pp → p+X at 22.4 GeV/c

    Some features of the reaction anti pp→p+X at 22.4 GeV/c are investigated using the statistically separated spectra of charged particles in the whole phase space. A change from the general trend in the behayiour of the average associated multiplicity at missing mass Msub(X)sup(2) approximately equal to 20 GeVsup(2) is found. This may be connected with the clusterization process, for instance, heavy resonance production. A confirmation of clusterization for Msub(x)sup(2)>=20GeVsup(2) is made when analyzing the rapidity gap distributions. The maxima of the structure functions are shifted towards larger missing masses with increasing multiplicity. It is shown that quark-parton model describes qualitatively the one-particle structure functions but does not reproduce the elusterization

  19. Electroacupuncture Combined with Flash Cupping for Treatment of Peripheral Facial Paralysis ——A Report of 224 Cases

    Tian Jianqi; Duan Shumin

    2007-01-01

    Objective: To observe the therapeutic effects of electroacupuncture plus flash cupping for peripheral facial paralysis. Method: The main points used were Jingming (BL 1), Yangbai (GB 14) and Sibai (ST 2) with the adjunct points selected according to the syndrome differentiation. The routine acupuncture,electroacupuncture and flash cupping were used to treat 224 cases of peripheral facial paralysis. Result:The total effective rate was 96%. Conclusion: Acupuncture can regulate the flow of blood and qi and dredge the channels and collaterals; the pulse electrotherapy can enhance excitation of the muscular tissues;and the flash cupping can make the local tissues to be in a state of high oxygen supply, benefiting blood circulation. The synergistic action of electroacupuncture and flash cupping can raise the therapeutic effect.

  20. Local Control of Lung Derived Tumors by Diffusing Alpha-Emitting Atoms Released From Intratumoral Wires Loaded With Radium-224

    Purpose: Diffusing alpha-emitters radiation therapy (DART) is a new form of brachytherapy enabling the treatment of solid tumors with alpha radiation. The present study examines the antitumoral effects resulting from the release of alpha emitting radioisotopes into solid lung carcinoma (LL2, A427, and NCI-H520). Methods and Materials: An in vitro setup tested the dose-dependent killing of tumor cells exposed to alpha particles. In in vivo studies, radioactive wires (0.3 mm diameter, 5 mm long) with 224Ra activities in the range of 21-38 kBq were inserted into LL/2 tumors in C57BL/6 mice and into human-derived A427 or NCI-H520 tumors in athymic mice. The efficacy of the short-lived daughters of 224Ra to produce tumor growth retardation and prolong life was assessed, and the spread of radioisotopes inside tumors was measured using autoradiography. Results: The insertion of a single DART wire into the center of 6- to 7-mm tumors had a pronounced retardation effect on tumor growth, leading to a significant inhibition of 49% (LL2) and 93% (A427) in tumor development and prolongations of 48% (LL2) in life expectancy. In the human model, more than 80% of the treated tumors disappeared or shrunk. Autoradiographic analysis of the treated sectioned tissue revealed the intratumoral distribution of the radioisotopes, and histological analysis showed corresponding areas of necrosis. In vitro experiments demonstrated a dose-dependent killing of tumors cells exposed to alpha particles. Conclusions: Short-lived diffusing alpha-emitters produced tumor growth retardation and increased survival in mice bearing lung tumor implants. These results justify further investigations with improved dose distributions.

  1. Sediment-water column fluxes of carbon, oxygen and nutrients in Bedford Basin, Nova Scotia, inferred from 224Ra measurements

    E. Horne

    2013-01-01

    Full Text Available Exchanges between sediment pore waters and the overlying water column play a significant role in the chemical budgets of many important chemical constituents. Direct quantification of such benthic fluxes requires explicit knowledge of the sediment properties and biogeochemistry. Alternatively, changes in water-column properties near the sediment-water interface can be exploited to gain insight into the sediment biogeochemistry and benthic fluxes. Here, we apply a 1-D diffusive mixing model to near-bottom water-column profiles of 224Ra activity in order to yield vertical eddy diffusivities (KZ, based upon which we assess the diffusive exchange of dissolved inorganic carbon (DIC, nutrients and oxygen (O2, across the sediment-water interface in a coastal inlet, Bedford Basin, Nova Scotia, Canada. Numerical model results are consistent with the assumptions regarding a constant, single benthic source of 224Ra, the lack of mixing by advective processes, and a predominantly benthic source and sink of DIC and O2, respectively, with minimal water-column respiration in the deep waters of Bedford Basin. Near-bottom observations of DIC, O2 and nutrients provide flux ratios similar to Redfield values, suggesting that benthic respiration of primarily marine organic matter is the dominant driver. Furthermore, a relative deficit of nitrate in the observed flux ratios indicates that denitrification also plays a role in the oxidation of organic matter, although its occurrence was not strong enough to allow us to detect the corresponding AT fluxes out of the sediment. Finally, comparison with other carbon sources reveal the observed benthic DIC release as a significant contributor to the Bedford Basin carbon system.

  2. Corrective Action Decision Document for Corrective Action Unit 224: Decon Pad and Septic Systems Nevada Test Site, Nevada, Rev. No.: 0

    David A. Strand

    2005-05-01

    This Corrective Action Decision Document has been prepared for Corrective Action Unit (CAU) 224, Decon Pad and Septic Systems, in Areas 2, 3, 5, 6, 11, and 23 of the Nevada Test Site, Nevada, in accordance with the ''Federal Facility Agreement and Consent Order'' (1996). Corrective Action Unit 224 is comprised of the following corrective action sites (CASs): (1) 02-04-01, Septic Tank (Buried); (2) 03-05-01, Leachfield; (3) 05-04-01, Septic Tanks (4)/Discharge Area; (4) 06-03-01, Sewage Lagoons (3); (5) 06-05-01, Leachfield; (6) 06-17-04, Decon Pad and Wastewater Catch; (7) 06-23-01, Decon Pad Discharge Piping; (8) 11-04-01, Sewage Lagoon; and (9) 23-05-02, Leachfield. The purpose of this Corrective Action Decision Document is to identify and provide the rationale for the recommendation of a corrective action alternative for the nine CASs within CAU 224. Corrective action investigation activities were performed from August 10, 2004, through January 18, 2005, as set forth in the CAU 224 Corrective Action Investigation Plan.

  3. Phase Conjugated Twin Waves in 8×21×224Gbit/s DP-16QAM Multi-core Fiber Transmission

    Asif, Rameez; Ye, Feihong; Morioka, Toshio

    2014-01-01

    Efficient suppression of non-linear interactions has been n umerically analyzed via phase conjugated twin waves in 8 × 21 × 224 Gbit/s multi-core fiber transmission. Results show a Q-factor improvement of 2.8 dB, consequently doubling the transmission distance....

  4. Nonlinear Equalization in 40/112/224 Gbit/s Mixed Line Rate 15-Channel DP-QPSK and DP-16QAM Contiguous Spectrum Based Networks

    Asif, Rameez

    2014-01-01

    We evaluated that in-line non-linear compensation schemes decrease the com- plexity of digital back-propagation and enhance the perfor mance of 40/112/224Gbit/s mixed line rate network. Both grouped and un-grouped spectral all ocation schemes are investigated....

  5. Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.

    Clint L Miller

    2014-03-01

    Full Text Available Genome-wide association studies (GWAS have identified chromosomal loci that affect risk of coronary heart disease (CHD independent of classical risk factors. One such association signal has been identified at 6q23.2 in both Caucasians and East Asians. The lead CHD-associated polymorphism in this region, rs12190287, resides in the 3' untranslated region (3'-UTR of TCF21, a basic-helix-loop-helix transcription factor, and is predicted to alter the seed binding sequence for miR-224. Allelic imbalance studies in circulating leukocytes and human coronary artery smooth muscle cells (HCASMC showed significant imbalance of the TCF21 transcript that correlated with genotype at rs12190287, consistent with this variant contributing to allele-specific expression differences. 3' UTR reporter gene transfection studies in HCASMC showed that the disease-associated C allele has reduced expression compared to the protective G allele. Kinetic analyses in vitro revealed faster RNA-RNA complex formation and greater binding of miR-224 with the TCF21 C allelic transcript. In addition, in vitro probing with Pb2+ and RNase T1 revealed structural differences between the TCF21 variants in proximity of the rs12190287 variant, which are predicted to provide greater access to the C allele for miR-224 binding. miR-224 and TCF21 expression levels were anti-correlated in HCASMC, and miR-224 modulates the transcriptional response of TCF21 to transforming growth factor-β (TGF-β and platelet derived growth factor (PDGF signaling in an allele-specific manner. Lastly, miR-224 and TCF21 were localized in human coronary artery lesions and anti-correlated during atherosclerosis. Together, these data suggest that miR-224 interaction with the TCF21 transcript contributes to allelic imbalance of this gene, thus partly explaining the genetic risk for coronary heart disease associated at 6q23.2. These studies implicating rs12190287 in the miRNA-dependent regulation of TCF21, in

  6. 不同胎龄及出生体质量双胎早产儿224例临床分析%Clinical Analysis of 224 Twin Premature Infants with Different Gestational Age and Birth Weight

    廖镇宇; 黄瑞文; 肖艾青

    2014-01-01

    【目的】分析不同胎龄及出生体质量双胎早产儿并发症发生率及死亡原因。【方法】将2010年7月至2012年7月在本院新生儿科住院的224例双胎早产儿,根据胎龄分为≤32周,~34周,~37周组,根据出生体质量分为<1500 g,~2500 g,≥2500 g组。比较各组患儿并发症的发生率及病死率。【结果】贫血、呼吸衰竭、早产儿视网膜病变、新生儿呼吸窘迫综合征、支气管肺发育不良在不同胎龄及出生体质量双胎早产儿组间比较差异有统计学意义(P<0.05),且胎龄越小,出生体质量越低,发生率越高;低血糖在不同胎龄及出生体质量双胎早产儿组间比较差异有统计学意义(P<0.05),且出生体质量越低,发生率越高;呼吸暂停在不同胎龄及出生体质量双胎早产儿组间比较差异有统计学意义(P<0.05)。224例患儿中死亡15例,病死率为6.7%。胎龄越小、出生体质量越低,病死率越高,各组间比较差异有统计学意义(P<0.05)。【结论】加强双胎早产儿孕母的保健工作,降低早产儿及低出生体质量儿的发生率;加强双胎早产儿常见并发症的防治,以降低其病死率。%[Obj ective]To analyze the incidence of the complications and mortality rate of twin premature infants with different gestational age and birth weight.[Methods]According to gestational age,224 twin premature infants hos-pitalized in neonate department of our hospital from July 2010 to July 2012 were divided into less than 32-week group,32~34-week group and 34~37 week group.According to birth weight,all patients were divided into less than 1500g group,1500-2500g group and more than 2500g group.The incidence of complications and mortality rate were compared among different groups.[Results]There were significant differences in the incidence of anemia,respiratory failure,reti-nopathy of prematurity

  7. Sediment-water column fluxes of carbon, oxygen and nutrients in Bedford Basin, Nova Scotia, inferred from 224Ra measurements

    E. Horne

    2012-07-01

    Full Text Available Exchanges between sediment pore waters and the overlying water column play a significant role in the chemical budgets of many important chemical constituents. Quantification of such benthic fluxes requires explicit knowledge of the sediment properties and biogeochemistry. Alternatively, changes in water column properties near the sediment-water column interface can be exploited to gain insight into the sediment biogeochemistry and benthic fluxes. Here, we apply a 1-D diffusive mixing model to near-bottom water column profiles of 224Ra activity in order to yield vertical eddy diffusivities (KZ, based upon which we assess the diffusive exchange of inorganic carbon (DIC, nutrients and oxygen (O2, across the sediment-water interface in a coastal inlet, Bedford Basin, Nova Scotia, Canada. Near-bottom observations of DIC, O2 and nutrients provide flux ratios similar to Redfield values, suggesting that benthic respiration of primarily marine organic matter is the dominant driver. Furthermore, we did not observe any significant release of alkalinity (AT from the sediments to the overlying water column, providing further insight into the dominant reactions taking place within sediments: the respiration of organic matter occurs largely under aerobic conditions or products of anaerobic processes are reoxidized quickly in oxygenated layers of the sediments. Finally, comparison with other carbon sources reveal the observed benthic DIC release as a significant contributor to the Bedford Basin carbon system.

  8. Scintigraphic, radiological and clinical results after /sup 224/Ra therapy in patients with Bechterew's disease

    Redecker, S.; Crone-Muenzebrock, W.; Weh, L.; Montz, R. (Hamburg Univ. (Germany, F.R.))

    1982-04-01

    53 patients with ancylosing spondylitis (clinical stages II and III) were treated with 1 MBq Ra 224 over a period of ten weeks. In 44 patients the orthopaedic findings were improved, in 9 patients they remained unchanged. An iridocyclitis developed in 3 patients, in 1 case an uveitis could be observed 33 patients were reexamined clinically, radiologically including total body scan and by laboratory means after an average period of 7.1 years. The stiftness of the spine was slightly improved compared with the pre-therapeutical status. Radiologically the spine findings were unchanged in 7 patients, progradient in 16, and clearly deteriorated in 8 cases. Scintiscanning of the skeleton of 21 patients showed a normal activity in 6 patients, 8 patients had a slight increase of the activity, mainly in the sacroiliac region 7 patients revealed a highly increased activity in the sacro-iliac region and lumbovertebral spine. Differential blood count and electrophoresis were unchanged before and after therapy. In 60% of the cases the erythrocyte sedimentation rate was diminished compared with pretherapy findings, in 40% the rate was unchanged or increased. Subjectively 10% of the patients reported no pain symptoms, 50% felt better, 30% were unchanged and 10% felt more poorly than before.

  9. Cataracts in patients injected with a solution of radium 224, colloidal platinum, and the red dye eosin (Peteosthor)

    Among 218 patients in the Spiess series injected with 224Ra as juveniles from 1943 to about 1952, 91 have died leaving 127 alive. Of these, 47 have been examined in detail with a slitlamp by an ophthalmologist and 25 were found to have some kind of lens opacity. In 14 out of the 25 the cataracts appeared morphologically similar to age-related cataracts. In 11 patients there was a bilateral posterior subcapsular cataract. In eight this was a bilateral dense round plaque with a clear subcapsular zone of about 0.5-0.6 mm. This clear zone corresponds to newly deposited lens fibres during the period of about 40 years from treatment to examination. By June 1984, 12 of the 218 were reported to have had cataract as cause of decreased visual acuity. The present study found 32 patients (25 examined recently and seven others) with cataract confirmed with a slitlamp by August 1988. Three additionally reported cataracts could not be updated. (author)

  10. Adsorption of herbicidally active degradate 2-(2,4-dichloro-3-methylphenoxy)propanoic acid on an andosol.

    Murano, Hirotatsu; Otani, Takashi; Furubayashi, Akihiro; Yamamura, Kohji; Kobayashi, Katsuichiro; Hiradate, Syuntaro

    2008-02-27

    The adsorption of 2-(2,4-dichloro-3-methylphenoxy)propanoic acid (DMPA) on the surface horizon of a humus-rich Andosol was examined. To investigate the mechanisms of adsorption, chemically treated Andosols, such as organic matter removed Andosol, organic matter and active metals removed Andosol, and clay minerals of the Andosol, were prepared. Furthermore, humic acid was extracted from the Andosol. The mechanisms of the DMPA adsorption were identified by using those untreated and chemically treated Andosols and the humic acid. The amount of DMPA adsorbed increased with decreasing equilibrium pH value. Active surface hydroxyl groups were identified as the most important soil functional group in DMPA adsorption. The predominant mechanism of DMPA adsorption on the Andosol is a ligand-exchange reaction, in which an active surface hydroxyl on Al and/or Fe is replaced by a carboxylic group of DMPA. A comparative study revealed that the amount of DMPA adsorbed was slightly greater than that of (2,4-dichlorophenoxy)acetic acid (2,4-D), especially at equilibrium pH values below 5. This is because the octanol-water partition coefficient (log Kow) of DMPA in the equilibrium pH range is higher than that of 2,4-D, and SOM participates in the adsorption process through a hydrophobic interaction. PMID:18247538

  11. 湖南省106 224例新生儿先天性甲状腺功能减低症筛查%Screening for congenital hypothyroidism in 106 224 neonates in Hunan Province

    伍细言; 王华; 黄定梅; 雷花香; 胡蓉; 马力; 邹珊静; 禹虹

    2005-01-01

    目的:早期诊断先天性甲状腺功能减退症(congenital hypothyroidism,CH)患儿,预防智力低下儿的发生.方法:采用时间分辨荧光免疫法测定促甲状腺素(thyroid-stimulating hormone,TSH)浓度,如果TSH筛查呈阳性,则使用化学发光免疫法(chemiluminescent immunoassay,CLIA)测定血清TSH、游离三碘甲状腺原氨酸(free triiodothyronine,FT3)、游离四碘甲状腺原氨酸(free thyroxin,FT4),并结合临床确诊.结果:湖南省1997年4月至2003年12月106 224份标本中共检出CH患儿68例,检出率1/1 562,明显高于全国平均水平(1/3 009).结论:(1)新生儿筛查是早期诊治CH患儿,预防CH发生智力低下的关键;(2)湖南为CH高发地区;(3)检出率与科学技术的发展呈相关性,累加检出率能更真实地反映发病率;(4)选择适当切值有助于防止漏筛.

  12. Expression of antisense miR-224 in colon cancer and its effect on cancer cell proliferation%反义 miR-224在结肠癌组织中的表达及其对癌细胞增殖的影响

    胡刚; 湛汇

    2015-01-01

    目的探讨微小 RNA(miRNA)miR-224在结肠癌组织中的表达,以及对体外癌细胞增殖和凋亡的影响。方法收集2011年2月至2014年3月行手术治疗的134例结肠癌和癌旁组织标本,利用实时荧光定量聚合酶链反应(Real-time PCR)检测标本中 miR-224表达情况;对人结肠癌细胞 SW480进行 miR-224反义寡核苷酸转染并培养,利用克隆形成实验和流式细胞仪检测 miR-224反义寡核苷酸对 SW480细胞增殖和凋亡的影响,利用 Real-time PCR 和 Western blot 法对不同转染组细胞中 Bcl-2表达情况进行检测。结果miR-224在结肠癌组织中相对表达水平显著高于癌旁组织(P <0.05);反义 miR-224组人结肠癌 SW480细胞克隆形成率显著低于对照组,而细胞凋亡指数则高于对照组,差异均具有统计学意义(P <0.05);反义 miR-224组细胞 Bcl-2相对表达量和蛋白相对表达量均低于对照组(P <0.05)。结论miR-224在结肠癌组织中呈高表达,减少 miR-224表达可抑制结肠癌细胞增殖,并加速细胞凋亡,有可能成为结肠癌早期发现及基因治疗的新靶位。%Objective To explore the expression of miR-224 in colon cancer and examine its effect on the proliferation and apoptosis of cancer cell.Methods A total of 134 cases of colon cancer and adjacent tissue specimens were collected from Feb.201 1 to Mar.2014.And the expression of miR-224 was detected by real-time polymerase chain reaction (PCR).Human colon cancer cell SW480 was transfected by miR-224 antisense oligonucleotide and cultured.The effects of miR-224 antisense oligonucleotide on cellular proliferation and apoptosis were detected by colony formation assay and flow cytometry.And the expressions of Bcl-2 in differentially transfected cells were detected by real-time PCR and Western blot.Results The relative expression of miR-224 was significantly higher in colon cancer tissue than that in adjacent tissues.And the difference was

  13. Oesteosarcomagenic doses of radium (224Ra) and infectious endogenous retroviruses enhance proliferation and osteogenic differentiation of skeletal tissue dofferentiating in vitro

    Cartilage tissue from embryonic mice which undergoes osteogenic differentiation during in vitro cultivation was used to study the effect of osteosarcomagenic doses of α-irradiation and bone-tumor-inducing retroviruses on proliferation and phenotypic differentiation of skeletal cells in a defined tissue culture model. Irradiated mandibular condyles showed dose-dependent enhancement of cell proliferation at day 7 of the culture and increased osteogenic differentiation at day 14. Maximal effects were found with 7.4 Bq/ml of 224Ra-labeled medium. Doses of 740 and 7400 Bq/ml of 224Ra-labeled medium induced increasing cell death. Retrovirus infection enhanced osteogenic differentiation and extended the viability of irradiated cells. After transplantation none of the treated tissues developed tumors in syngeneic mice. (orig.)

  14. Oesteosarcomagenic doses of radium ([sup 224]Ra) and infectious endogenous retroviruses enhance proliferation and osteogenic differentiation of skeletal tissue dofferentiating in vitro

    Schmidt, J. (Inst. fuer Molekulare Virologie, GSF-Forschungszentrum fuer Umwelt und Gesundheit GmbH, Neuherberg (Germany)); Heermeier, K. (Inst. fuer Molekulare Virologie, GSF-Forschungszentrum fuer Umwelt und Gesundheit GmbH, Neuherberg (Germany)); Linzner, U. (Inst. fuer Pathologie, GSF-Forschungszentrum fuer Umwelt und Gesundheit GmbH, Neuherberg (Germany)); Luz, A. (Inst. fuer Pathologie, GSF-Forschungszentrum fuer Umwelt und Gesundheit GmbH, Neuherberg (Germany)); Silbermann, M. (Lab. of Musculoskeletal Research, Rappaport Family Inst. for Research in the Medical Sciences, Bruce Rappaport Faculty of Medicine, Technion, Haifa (Israel)); Livne, E. (Lab. of Musculoskeletal Research, Rappaport Family Inst. for Research in the Medical Sciences, Bruce Rappaport Faculty of Medicine, Technion, Haifa (Israel)); Erfle, V. (Inst. fuer Molekulare Virologie, GSF-Forschungszentrum fuer Umwelt und Gesundheit GmbH, Neuherberg (Germany))

    1994-01-01

    Cartilage tissue from embryonic mice which undergoes osteogenic differentiation during in vitro cultivation was used to study the effect of osteosarcomagenic doses of [alpha]-irradiation and bone-tumor-inducing retroviruses on proliferation and phenotypic differentiation of skeletal cells in a defined tissue culture model. Irradiated mandibular condyles showed dose-dependent enhancement of cell proliferation at day 7 of the culture and increased osteogenic differentiation at day 14. Maximal effects were found with 7.4 Bq/ml of [sup 224]Ra-labeled medium. Doses of 740 and 7400 Bq/ml of [sup 224]Ra-labeled medium induced increasing cell death. Retrovirus infection enhanced osteogenic differentiation and extended the viability of irradiated cells. After transplantation none of the treated tissues developed tumors in syngeneic mice. (orig.)

  15. Densities, viscosities, refractive indices, and surface tensions for binary and ternary mixtures of 2-propanol, tetrahydropyran, and 2,2,4-trimethylpentane

    Densities, viscosities, refractive indices, and surface tensions of the ternary system (2-propanol + tetrahydropyran + 2,2,4-trimethylpentane) at T = 303.15 K and its constituent binary systems (2-propanol + tetrahydropyran, 2-propanol + 2,2,4-trimethylpentane, and tetrahydropyran + 2,2,4-trimethylpentane) at T = (293.15, 303.15, 313.15, and 323.15) K were measured at atmospheric pressure. Densities were determined using a vibrating-tube densimeter. Viscosities were measured with an automatic microviscometer based on the rolling-ball principle. Refractive indexes were measured using a digital Abbe-type refractometer. Surface tensions were determined by the Wilhelmy-plate method. From these data, excess molar volumes, deviations in viscosity, deviations in refractive index, and deviations in surface tension were calculated. The results for the binary and ternary systems were fitted to the Redlich-Kister equation and the variable-degree polynomials in terms of compositions, respectively. The experimental and calculated quantities are used to study the nature of mixing behaviour between mixture components.

  16. Risk of leukaemia following intravenous treatment with 224Ra - results of a long term follow-up study of ankylosing spondylitis patients

    In an epidemiological study of the somatic late effects risk following incorporation of a short lived α-emitter, 1473 ankylosing spondylitis patients treated with repeated intravenous injections of 224Ra in the years 1948 - 75, have been observed in the GSF. The usual therapeutic plan consisted of a total of 10 - 12 injections of 1.036 MBq (28 μCi) of 224Ra each, given at weekly intervals; this would result in an cumulative α-dose of 0.56 - 0.67 Gy to the marrow-free skeleton of a 70-kg-man (standard man). These patients have been followed together with a control group of ankylosing spondylitis patients not treated with radioactive drugs and/or X-rays. Until May 1993 (mean follow-up time 19.9 yr), 595 patients of the exposure group and 722 patients of the control group have died, causes of death have been ascertained for 578, resp. 668 patients. Among others we observed in the exposure group 10 cases of leukaemia (vs. 2.7 - 2.8 cases expected, p 239Pu, an α-emitter which like 224Ra deposits preferentially on the bone surface. (orig.)

  17. Verification of anticlockwise gyre in the semi-closed water area of Lake Nakaumi, southwest Japan, by using 224Ra/228Ra activity ratios

    The Honjyo area in Lake Nakaumi is a semi-closed brackish water area where some mixing of up-flowing marine water and down-flowing lake water take place. A large-scale gyre that caused by the residual circulation was once indicated by a temporal algal blooming that spread over the semi-closed Honjyo area in brackish Lake Nakaumi. In order to verify this type of water circulation, we examined 224Ra (t1/2=3.66 d)/228Ra (t1/2=5.75 y) activity ratios of both upper and lower waters that differentiated by a well-developed halocline. The 224Ra/228Ra ratios in the upper water were lowest in the central area, suggesting the formation of anticlockwise gyre. The ratios in the lower water were rather uniform, but a basin-wide anticlockwise flow of water is also indicated. The 224Ra/228Ra ratio is clearly effective to trace the water flow for both the deep and surface waters. (author)

  18. Comment: 224 [Taxonomy Icon

    Full Text Available ty of Tokyo) licensed under CC Attribution2.1 Japan ヨコヅナクマムシ 光学顕微鏡写真 撮影:國枝武和(東京大学) bando 2010/02/15 14:55:40 2010/02/16 10:42:46 ...

  19. 2,2,4-Trimethylpentane-induced nephrotoxicity. I. Metabolic disposition of TMP in male and female Fischer 344 rats

    2,2,4-Trimethylpentane (TMP), a component of unleaded gasoline, causes nephrotoxicity in male, but not in female, rats. In the present study, male and female Fischer 344 rats were treated with a single oral dose of [14C]TMP (4.4 mmol/kg; 2 microCi/mmol). Radiolabeled material in kidney, liver, and plasma was determined at 4, 8, 12, 24, and 48 hr after dosing. Maximum concentration of TMP-derived radioactivity in kidney, liver, and plasma of male rats was found after 12 hr (1252, 1000, and 403 nmol eq/g, respectively), whereas those measured in females were found after 8 hr (577, 1163, and 317 nmol eq/g, respectively). A selective retention of the TMP-derived radiolabel in the kidneys of male rats was noted when peak tissue concentration was expressed as a percentage of administered dose. Kidney concentrations of TMP-derived radiolabel increased in a nonlinear, but dose-dependent, manner; the kidney to plasma ratio was greater at low doses than at higher doses. Increased retention of radiolabel material in the kidney was associated with a significant increase in renal concentration of the male-rat-specific protein, alpha 2u-globulin, 24 and 48 hr after TMP administration. Total radioactivity collected in urine 48 hr after TMP administration was similar in males and females (32 and 31% of dose). Identification and quantitation of the urinary metabolites of TMP showed that both male and female rats metabolize TMP via the same pathway and at a similar rate. Female rats, however, excreted more conjugates of 2,4,4-trimethyl-2-pentanol in urine than males. 2,4,4-Trimethyl-2-pentanol was the major metabolite present in the male rat kidney, but was absent in the female rat kidney. The renal retention of 2,4,4-trimethyl-2-pentanol appears to account for the delayed clearance observed in the disposition of [14C]TMP-derived radiolabel

  20. Distribution of (223)Ra and (224)Ra in the Bo Sea embayment in Tianjin and its implication of submarine groundwater discharge.

    Liu, Lingling; Yi, Lixin; Cheng, Xiaoqing; Tang, Guoqiang

    2015-12-01

    Submarine groundwater discharge (SGD) is now recognized as an important pathway between land and sea. In this study, in order to analyze the distribution of naturally occurring short-lived radium isotopes and the relative SGD effect in Bo Sea embayment, (223)Ra and (224)Ra were measured in three parts of the embayment with the radium-delayed coincidence counting (RaDeCC) system. Subsequently, the mixing process was studied by the calculation of diffusion coefficients (Kx and Kz) and advection velocities (Vx and Vz) based on the 2D advection-diffusion model. Additionally, the apparent residence ages and SGD flux were quantified based on the (224)Ra and (223)Ra activities. The results showed that the Ra activities exponentially decreased with the distance offshore, and both the Kx and Vx took the order of northern part > southern part > middle part. In vertical direction, there was the maximum value of Vz and minimum Kz in middle part and the maximum Kz and minimum Vz in southern part. The average ages for the northern, middle and southern parts were 4.28, 7.38 and 3.73 days, respectively. The final SGD flux yielded by (224)Ra was 0.09, 0.01 and 0.03 m d(-1) in the northern, middle and southern parts, respectively. The SGD flux yielded by (223)Ra was 0.08, 0.01 and 0.03 m d(-1) in northern, middle and southern parts, respectively. The result indicates that there is the fastest exchange rate and the biggest SGD flux in the southern part in Bo Sea embayment. PMID:26318773

  1. The Equilibrium and Pre-Equilibrium Neutron Emission Spectra of Some Deformed Target Nuclei for (p,xn) Reactions up to 22.4 MeV

    In this study, by using equilibrium and pre-equilibrium reaction mechanisms, neutron-emission spectra produced by (p,xn) reactions for some deformed target nuclei as 165Ho, 181Ta and 232Th have been calculated the bombarding energies up to 22.4 MeV. In the calculations, pre-equilibrium calculations were calculated by using new evaluated hybrid model and geometry dependent hybrid model, full exciton model and cascade exciton model. The reaction equilibrium component was calculated by Weisskopf-Ewing model. The obtained results have been discussed and compared with the available experimental data and found agreement with each other

  2. Optical variability of the BL Lacertae object GC 0109+224. Multiband behaviour and time scales from a 7-years monitoring campaign

    Ciprini, S; Raiteri, C M; Villata, M; Ibrahimov, M A; Nucciarelli, G; Lanteri, L

    2003-01-01

    We present the most continuous data base of optical $BVR_{c}I_{c}$ observations ever published on the BL Lacertae object GC 0109+224, collected mainly by the robotic telescope of the Perugia University Observatory in the period November 1994-February 2002. These observations have been complemented by data from the Torino Observatory, collected in the period July 1995-January 1999, and Mt. Maidanak Observatory (December 2000). GC 0109+224 showed rapid optical variations and six major outbursts were observed at the beginning and end of 1996, in fall 1998, at the beginning and at the end of 2000, and at the beginning of 2002. Fast and large-amplitude drops characterized its flux behaviour. The $R_c$ magnitude ranged from 13.3 (16.16 mJy) to 16.46 (0.8 mJy), with a mean value of 14.9 (3.38 mJy). In the periods where we collected multi-filter observations, we analyzed colour and spectral indexes, and the variability patterns during some flares. The long-term behaviour seems approximatively achromatic, but during s...

  3. Directed and elliptic flow of charged particles in Cu+Cu collisions at $\\sqrt{\\bm {s_{NN}}} =$ 22.4 GeV

    Agakishiev, G; Ahammed, Z; Alakhverdyants, A V; Alekseev, I; Alford, J; Anderson, B D; Anson, C D; Arkhipkin, D; Averichev, G S; Balewski, J; Beavis, D R; Behera, N K; Bellwied, R; Betancourt, M J; Betts, R R; Bhasin, A; Bhati, A K; Bichsel, H; Bielcik, J; Bielcikova, J; Bland, L C; Bordyuzhin, I G; Borowski, W; Bouchet, J; Braidot, E; Brandin, A V; Bridgeman, A; Brovko, S G; Bruna, E; Bueltmann, S; Bunzarov, I; Burton, T P; Cai, X Z; Caines, H; Sánchez, M Calderón de la Barca; Cebra, D; Cendejas, R; Cervantes, M C; Chaloupka, P; Chattopadhyay, S; Chen, H F; Chen, J H; Chen, J Y; Chen, L; Cheng, J; Cherney, M; Chikanian, A; Choi, K E; Christie, W; Chung, P; Codrington, M J M; Corliss, R; Cramer, J G; Crawford, H J; Cui,; Leyva, A Davila; De Silva, L C; Debbe, R R; Dedovich, T G; Deng, J; Derevschikov, A A; de Souza, R Derradi; Didenko, L; Djawotho, P; Dogra, S M; Dong, X; Drachenberg, J L; Draper, J E; Du, C M; Dunlop, J C; Efimov, L G; Elnimr, M; Engelage, J; Eppley, G; Estienne, M; Eun, L; Evdokimov, O; Fatemi, R; Fedorisin, J; Fersch, R G; Filip, P; Finch, E; Fine, V; Fisyak, Y; Gagliardi, C A; Gangadharan, D R; Geurts, F; Ghosh, P; Gorbunov, Y N; Gordon, A; Grebenyuk, O G; Grosnick, D; Gupta, A; Gupta, S; Guryn, W; Haag, B; Hajkova, O; Hamed, A; Han, L-X; Harris, J W; Hays-Wehle, J P; Heinz, M; Heppelmann, S; Hirsch, A; Hjort, E; Hoffmann, G W; Hofman, D J; Huang, B; Huang, H Z; Humanic, T J; Huo, L; Igo, G; Jacobs, P; Jacobs, W W; Jena, C; Jin, F; Joseph, J; Judd, E G; Kabana, S; Kang, K; Kapitan, J; Kauder, K; Ke, H W; Keane, D; Kechechyan, A; Kettler, D; Kikola, D P; Kiryluk, J; Kisiel, A; Kizka, V; Klein, S R; Knospe, A G; Koetke, D D; Kollegger, T; Konzer, J; Koralt, I; Koroleva, L; Korsch, W; Kotchenda, L; Kouchpil, V; Kravtsov, P; Krueger, K; Krus, M; Kumar, L; Lamont, M A C; Landgraf, J M; LaPointe, S; Lauret, J; Lebedev, A; Lednicky, R; Lee, J H; Leight, W; LeVine, M J; Li, C; Li, L; Li, N; Li, W; Li, X; Li, X; Li, Y; Li, Z M; Lima, 1 L M; Lisa, M A; Liu, F; Liu, H; Liu, J; Ljubicic, T; Llope, W J; Longacre, R S; Lu, Y; Lukashov, E V; Luo, X; Ma, G L; Ma, Y G; Mahapatra, D P; Majka, R; Mall, O I; Manweiler, R; Margetis, S; Markert, C; Masui, H; Matis, H S; McDonald, D; McShane, T S; Meschanin, A; Milner, R; Minaev, N G; Mioduszewski, S; Mitrovski, M K; Mohammed, Y; Mohanty, B; Mondal, M M; Morozov, B; Morozov, D A; Munhoz, M G; Mustafa, M K; Naglis, M; Nandi, B K; Nayak, T K; Nogach, L V; Nurushev, S B; Odyniec, G; Ogawa, A; Oh, K; Ohlson, A; Okorokov, V; Oldag, E W; Oliveira, R A N; Olson, D; Pachr, M; Page, B S; Pal, S K; Pandit, Y; Panebratsev, Y; Pawlak, T; Pei, H; Peitzmann, T; Perkins, C; Peryt, W; Pile, P; Planinic, M; Ploskon, M A; Pluta, J; Plyku, D; Poljak, N; Porter, J; Poskanzer, A M; Potukuchi, B V K S; Powell, C B; Prindle, D; Pruneau, C; Pruthi, N K; Pujahari, P R; Putschke, J; Qiu, H; Raniwala, R; Raniwala, S; Ray, R L; Redwine, R; Reed, R; Ritter, H G; Roberts, J B; Rogachevskiy, O V; Romero, J L; Ruan, L; Rusnak, J; Sahoo, N R; Sakrejda, I; Salur, S; Sandweiss, J; Sangaline, E; Sarkar, A; Schambach, J; Scharenberg, R P; Schaub, J; Schmah, A M; Schmitz, N; Schuster, T R; Seele, J; Seger, J; Selyuzhenkov, I; Seyboth, P; Shah, N; Shahaliev, E; Shao, M; Sharma, M; Shi, S S; Shou, Q Y; Sichtermann, E P; Simon, F; Singaraju, R N; Skoby, M J; Smirnov, N; Solanki, D; Sorensen, P; deSouza, U G; Spinka, H M; Srivastava, B; Stanislaus, T D S; Steadman, S G; Stevens, J R; Stock, R; Strikhanov, M; Stringfellow, B; Suaide, A A P; Suarez, M C; Subba, N L; Sumbera, M; Sun, X M; Sun, Y; Sun, Z; Surrow, B; Svirida, D N; Symons, T J M; de Toledo, A Szanto; Takahashi, J; Tang, A H; Tang, Z; Tarini, L H; Tarnowsky, T; Thein, D; Thomas, J H; Tian, J; Timmins, A R; Tlusty, D; Tokarev, M; Trentalange, S; Tribble, R E; Tribedy, P; Trzeciak, B A; Tsai, O D; Ullrich, T; Underwood, D G; Van Buren, G; van Nieuwenhuizen, G; Vanfossen, J A; Jr.,; Varma, R; Vasconcelos, G M S; Vasiliev, A N; Videbæk, F; Viyogi, Y P; Vokal, S; Voloshin, S A; Wada, M; Walker, M; Wang, F; Wang, G; Wang, H; Wang, J S; Wang, Q; Wang, X L; Wang, Y; Webb, G; Webb, J C; Westfall, G D; Whitten, C; Wieman, H; Wissink, S W; Witt, R; Witzke, W; Wu, Y F; Xiao, Z; Xie, W; Xu, H; Xu, N; Xu, Q H; Xu, W; Xu, Y; Xu, Z; Xue, L; Yang, Y; Yang, Y; Yepes, P; Yip, K; Yoo, I-K; Zawisza, M; Zbroszczyk, H; Zhan, W; Zhang, J B; Zhang, S; Zhang, W M; Zhang, X P; Zhang, Y; Zhang, Z P; Zhao, F; Zhao, J; Zhong, C; Zhu, X; Zhu, Y H; Zoulkarneeva, Y

    2011-01-01

    This paper reports results for directed flow $v_{1}$ and elliptic flow $v_{2}$ of charged particles in Cu+Cu collisions at $\\sqrt{s_{NN}}=$ 22.4 GeV at the Relativistic Heavy Ion Collider. The measurements are for the 0-60% most central collisions, using charged particles observed in the STAR detector. Our measurements extend to 22.4 GeV Cu+Cu collisions the prior observation that $v_1$ is independent of the system size at 62.4 and 200 GeV, and also extend the scaling of $v_1$ with $\\eta/y_{\\rm beam}$ to this system. The measured $v_2(p_T)$ in Cu+Cu collisions is similar for $\\sqrt{s_{NN}} = 22.4-200$ GeV. We also report a comparison with results from transport model (UrQMD and AMPT) calculations. The model results do not agree quantitatively with the measured $v_1(\\eta), v_2(p_T)$ and $v_2(\\eta)$.

  4. High sensitivity measurement of 224Ra and 226Ra in water with an improved hydrous titanium oxide technique at the Sudbury Neutrino Observatory

    Aharmim, B; Dai, X; Doucas, G; Farine, J; Fergani, H; Ford, R; Hahn, R L; Hallman, E D; Jelley, N A; Lange, R; Majerus, S; Mifflin, C; Noble, A J; O'Keeffe, H M; Rodriguez-Jimenez, R; Sinclair, D; Yeh, M

    2008-01-01

    The existing hydrous titanium oxide (HTiO) technique for the measurement of 224Ra and 226Ra in the water at the Sudbury Neutrino Observatory (SNO) has been changed to make it faster and less sensitive to trace impurities in the HTiO eluate. Using HTiO-loaded filters followed by cation exchange adsorption and HTiO co-precipitation, Ra isotopes from 200-450 tonnes of heavy water can be extracted and concentrated into a single sample of a few millilitres with a total chemical efficiency of 50%. Combined with beta-alpha coincidence counting, this method is capable of measuring 2.0x10^3 uBq/kg of 224Ra and 3.7x10^3 uBq/kg of 226Ra from the 232Th and 238U decay chains, respectively, for a 275 tonne D2O assay, which are equivalent to 5x10^16 g Th/g and 3x10^16 g U/g in heavy water.

  5. Synergistic Effect of S224P and N383D Substitutions in the PA of H5N1 Avian Influenza Virus Contributes to Mammalian Adaptation

    Song, Jiasheng; Xu, Jing; Shi, Jianzhong; Li, Yanbing; Chen, Hualan

    2015-01-01

    The adaptation of H5N1 avian influenza viruses to human poses a great threat to public health. Previous studies indicate the adaptive mutations in viral polymerase of avian influenza viruses are major contributors in overcoming the host species barrier, with the majority of mammalian adaptive mutations occurring in the PB2 protein. However, the adaptive mutations in the PA protein of the H5N1 avian influenza virus are less defined and poorly understood. In this study, we identified the synergistic effect of the PA/224P + 383D of H5N1 avian influenza viruses and its ability to enhance the pathogenicity and viral replication in a mammalian mouse model. Interestingly, the signature of PA/224P + 383D mainly exists in mammalian isolates of the H5N1 influenza virus and pdmH1N1 influenza virus, providing a potential pathway for the natural adaptation to mammals which imply the effects of natural adaptation to mammals. Notably, the mutation of PA/383D, which is highly conserved in avian influenza viruses, increases the polymerase activity in both avian and human cells, and may have roles in maintaining the avian influenza virus in their avian reservoirs, and jumping species to infect humans. PMID:26000865

  6. Prostate cancer stem cell-targeted efficacy of a new-generation taxoid, SBT-1214 and novel polyenolic zinc-binding curcuminoid, CMC2.24.

    Galina I Botchkina

    Full Text Available BACKGROUND: Prostate cancer is the second leading cause of cancer death among men. Multiple evidence suggests that a population of tumor-initiating, or cancer stem cells (CSCs is responsible for cancer development and exceptional drug resistance, representing a highly important therapeutic target. The present study evaluated CSC-specific alterations induced by new-generation taxoid SBT-1214 and a novel polyenolic zinc-binding curcuminoid, CMC2.24, in prostate CSCs. PRINCIPAL FINDINGS: The CD133(high/CD44(high phenotype was isolated from spontaneously immortalized patient-derived PPT2 cells and highly metastatic PC3MM2 cells. Weekly treatment of the NOD/SCID mice bearing PPT2- and PC3MM3-induced tumors with the SBT-1214 led to dramatic suppression of tumor growth. Four of six PPT2 and 3 of 6 PC3MM2 tumors have shown the absence of viable cells in residual tumors. In vitro, SBT-1214 (100 nM-1 µM; for 72 hr induced about 60% cell death in CD133(high/CD44(+/high cells cultured on collagen I in stem cell medium (in contrast, the same doses of paclitaxel increased proliferation of these cells. The cytotoxic effects were increased when SBT-1214 was combined with the CMC2.24. A stem cell-specific PCR array assay revealed that this drug combination mediated massive inhibition of multiple constitutively up-regulated stem cell-related genes, including key pluripotency transcription factors. Importantly, this drug combination induced expression of p21 and p53, which were absent in CD133(high/CD44(high cells. Viable cells that survived this treatment regimen were no longer able to induce secondary spheroids, exhibited significant morphological abnormalities and died in 2-5 days. CONCLUSIONS: We report here that the SBT-1214 alone, or in combination with CMC2.24, possesses significant activity against prostate CD133(high/CD44(+/high tumor-initiating cells. This drug combination efficiently inhibits expression of the majority of stem cell-related genes and

  7. The Formation of 2,2,4-Trimethyl-2,3-dihydro-1H-1,5-Benzodiazepine from 1,2-Diaminobenzene in the Presence of Acetone

    Felix Odame

    2013-11-01

    Full Text Available In an attempt to synthesize a 2-substituted benzimidazole from the reaction of o-phenylenediamine and isophthalic acid in the presence of acetone and ethanol under microwave irradiation, a salt of the isophthalate ion and 2,2,4-trimethyl-2,3-dihydro-1H-1,5-benzodiazepin-5-ium ion was obtained. The condensation of two moles of acetone with the amine groups resulted in the formation of the benzodiazepine which crystallized as an iminium cation forming a salt with the isophthalate anion. The formation of benzodiazepine was also confirmed by performing the reaction of o-phenylenediamine with excess acetone in ethanol under conventional heating conditions. The compounds were characterized by NMR, FTIR, HRMS and microanalysis as well as X-ray crystallography. The reaction mechanism leading to the formation of benzodiazepine is also discussed.

  8. Corrective Action Investigation Plan for Corrective Action Unit 224: Decon Pad and Septic Systems Nevada Test Site, Nevada, Rev. No.: 0, with ROTC 1 and 2

    David A. Strand

    2004-04-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information including facility descriptions, environmental sample collection objectives, and criteria for conducting site investigation activities at Corrective Action Unit (CAU) 224: Decon Pad and Septic Systems, Nevada Test Site (NTS), Nevada. This CAIP has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense (DoD). The NTS is approximately 65 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Corrective Action Unit 224 is comprised of the nine Corrective Action Sites (CASs) listed below: 02-04-01, Septic Tank (Buried); 03-05-01, Leachfield; 05-04-01, Septic Tanks (4)/Discharge Area; 06-03-01, Sewage Lagoons (3); 06-05-01, Leachfield; 06-17-04, Decon Pad and Wastewater Catch; 06-23-01, Decon Pad Discharge Piping; 11-04-01, Sewage Lagoon; and 23-05-02, Leachfield. Corrective Action Sites 06-05-01, 06-23-01, and 23-05-02 were identified in the 1991 Reynolds Electrical & Engineering Co., Inc. (REECo) inventory (1991). The remaining sites were identified during review of various historical documents. Additional information will be obtained by conducting a corrective action investigation (CAI) prior to evaluating and selecting a corrective action alternative for each CAS. The CAI will include field inspections, radiological and geological surveys, and sample collection. Data will also be obtained to support investigation-derived waste (IDW) disposal and potential future waste management decisions.

  9. Occurrence of 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate (Texanol) in foods packed in polystyrene and polypropylene cups.

    Kempf, M; Ramm, S; Feuerbach, T; Schreier, P

    2009-04-01

    After simultaneous distillation-extraction (SDE) of foods packed in polystyrene (n = 77) and polypropylene cups (n = 42) from 61 different suppliers, coupled capillary gas chromatography-mass spectrometric (HRGC-MS) analyses indicated the presence of diastereomers of 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate (TMPD-MIB; Texanol), a known coalescent of paints and printing inks. The contaminant was found in 55 and 50% of the polystyrene and polypropylene packed samples, respectively. Amounts ranged 1.2-64.5 microg kg(-1) in polystyrene cups (average 25.1 microg kg(-1)) and 0.9-45.7 microg kg(-1) in polypropylene cups (average 10.8 microg kg(-1)). The origin of Texanol in the printed plastic cups was demonstrated by separate HRGC-MS analysis, showing amounts in the higher microg kg(-1) range. In addition, the presence of two pairs of enantiomers, both found to be racemic by enantioselective multi-dimensional gas chromatography-mass spectrometry (enantio-MDGC-MS), excluded it being of natural origin. The detection limit of overall procedure (DLOP) and the reliable quantification limit (RQL) were 0.2 and 0.9 microg kg(-1), respectively. As the diester, 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TXIB), is on the EU list of regulated substances (restricted to single-use gloves only) with a migration limit of 5 mg kg(-1) in food and is metabolised rapidly by hydrolysis, the observed migration of the monoester Texanol at the microg kg(-1) level poses no risk of adverse effects. PMID:19680930

  10. Single-Crystal X-ray Diffraction Structure of the Stable Enol Tautomer Polymorph of Barbituric Acid at 224 and 95 K.

    Marshall, Madalynn G; Lopez-Diaz, Valerie; Hudson, Bruce S

    2016-01-01

    The thermodynamically stable enol crystal form of barbituric acid, previously prepared as powder by grinding or slurry methods, has been obtained as single crystals by slow cooling from methanol solution. The selection of the enol crystal was facilitated by a density-gradient method. The structure at 224 and 95 K confirms the enol inferred on the basis of powder data. The enol has bond lengths that are consistent with the expected bond order and with DFT calculations that include treatment of hydrogen bonding. In isolation, the enol is higher in energy than the tri-keto form by 50 kJ mol(-1) which must be more than compensated by enhanced hydrogen bonding. Both crystal forms have four normal H-bonds; the enol has two additional H-bonds with O-O distances of 2.49 Å. Conversion into the enol form occurs spontaneously in the solid state upon prolonged storage of the commercial tri-keto material. Slurry conversion of tri-one to enol in ethanol is reversed in direction in ethanol-D1 . PMID:26662287

  11. Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g

    Background and purpose: Preoperative chemoradiotherapy (CRT) represents the standard treatment for locally advanced rectal cancer. Tumor response and progression vary considerably. MicroRNAs represent master regulators of gene expression, and may therefore contribute to this diversity. Material and methods: Genome-wide microRNA (miRNA) profiling was performed for 12 colorectal cancer (CRC) cell lines and an individual in vitro signature of chemoradiosensitivity was established. Functional relevance of selected miRNAs was established by transfecting miRNA-mimics into SW480 and SW837 cells. The prognostic value of selected miRNAs was assessed in 128 pretherapeutic patient biopsies. Results: Thirty-six miRNAs were identified to significantly correlate with sensitivity to CRT (Q < 0.05) including miR-320a and other miRNAs involved in the MAPK-, TGF- and Wnt-pathway. Transfection of selected miRNAs (let-7g, miR-132, miR-224, miR-320a) each induced a shift of sensitivity. High expression of let-7g was associated with a good prognosis in rectal cancer patients (P = 0.03). Conclusions: This is the first report of a miRNA expression signature for in vitro chemoradiosensitivity of CRC cell lines. Many of the identified miRNAs have not been linked to the response to CRT and may represent potential molecular targets to sensitize resistant cancers. If further validated, let7g expression may serve as predictive biomarker

  12. 三个新HLA等位基因A*24:224,A*24:225和A*24:257的测序鉴定%Identification of 3 novel HLA-A alleles A * 24: 224, A * 24 : 225 and A * 24: 257 by sequence-based typing

    朱传福; 张红卫; 张毅; 聂向民

    2015-01-01

    目的 鉴定3个在中国汉族人群中发现的人类白细胞抗原(human leukocyte antigen,HLA)A位点新等位基因A* 24:224、A* 24:225和A* 24:257.方法 应用双链直接测序分型技术进行中华骨髓库志愿者常规HLA分型,对其中HLA-A位点无完全匹配结果者,采用等位基因特异性扩增测序分型方法进行新等位基因序列鉴定.结果 3例先证者在HLA-A位点分别有一个未知的新碱基序列,3个新序列均与HLA-A* 24:02:01:01最为相近,但在第2外显子分别出现了1或2个的碱基取代,并导致相应的密码子及其编码的氨基酸的改变.结论 3个新碱基序列均确认为HLA-A新等位基因,分别于2012年11月和2013年11月被世界卫生组织HLA因子命名委员会正式命名为HLA-A* 24:224、HLA-A*24:225和HLA-A* 24:257.%Objective To verify 3 novel HLA-A alleles A * 24:224,A * 24:225 and A * 24:257 identified in Chinese Han individuals.Methods No full matched results were obtained at HLA-A locus in HLA typing for China Marrow Donor Program (CMDP) using bi-allelic Sequence-Based Typing (SBT).The novel HLA alleles were identified with allele-specific amplification SBT.Results All of the three probands had a novel nucleotide sequence at HLA-A locus.All of the 3 new sequences are most close to HLA-A* 24:02:01:01 except for 1 or 2 nucleotide substitution in exon 2,which resulted in different changes in corresponding codons and encoded amino acids.Conclusion Three novel HLA-A alleles were confirmed and officially named as HLA-A * 24:224,HLA-A * 24:225 and HLA-A * 24:257 under the GenBank accession numbers JQ899198,JQ924283 and HG003642 by the WHO Nomenclature Committee for Factors of the HLA System in November 2012 and November 2013,respectively.

  13. Cross-sections of two-prong exclusive reactions in ¯pp Interactions at22.4 GeV/c: Alma Ata-Dubna-Helsinki-Moscow-Prague Collaboration

    Batyunya, B. V.; Boguslavsky, I. V.; Bruncko, D.; Gramenitsky, I. M.; Lednický, R.; Medved, K. S.; Vrba, V.; Boos, E. G.; Ermilova, D. I.; Temiraliev, T.; Dementiev, R. K.; Rud, V. I.; Korzhavina, I. A.; Tikhonova, L. A.; Levonian, S. V.; Herynek, I.; Lokajíček, M.; Řídký, J.; Šimák, V.; Valkárová, A.; Kanazirsky, H.; Zlatanov, Z.; Villanen, P.; Walck, E.

    1988-03-01

    The results of the cross-section determination of some two-prong final states with one neutral particle (1 C-fits) in ¯ pp-interactions at 22.4 GeV/ c are presented. These results have been obtained from pictures of the HBC “Ludmila”. The methodical problems of the reaction selection are presented, the fulfilling of CP-invariance channels is demonstrated and the energetic behaviour of their cross-sections is analysed.

  14. Heteroleptic Ir(III) complexes based on 2-(2,4-difluorophenyl)-pyridine and bisthienylethene: structures, luminescence and photochromic properties.

    Cao, Deng-Ke; Wei, Ruo-Hong; Li, Xiao-Xiong; Chen, Jun-Feng; Ward, Michael D

    2015-03-01

    Two bisthienylethenes 2-(2-hydroxyphenyl)-4,5-bis[2,5-dimethyl(3-thienyl)]-1H-imidazole (L1H) and 2-(2-hydroxyphenyl)-4,5-bis(2,5-dimethyl(3-thienyl))-1-phenyl-imidazole (L2H), which have a chelating N,O-donor binding site attached to the photochromic core, have been synthesized using a one-pot condensation reaction, and used to prepare the heteroleptic complexes [Ir(dfppy)2(L1)]·2CH3OH (1) and [Ir(dfppy)2(L2)] (2) [dfppyH = 2-(2,4-difluorophenyl)-pyridine]. In the crystal structures of all four compounds, two thiophene groups of each bisthienylethene molecule adopt parallel conformation. Neighboring molecules in L1H and 1 are linked into supramolecular chains through hydrogen bonds. Particularly, the packing structure of 1 contains right- and left-handed 2₁ helical chains. In contrast, neighboring molecules in L2H and 2 interact only through van der Waals interactions. At room temperature, L1H and L2H in CH2Cl2 show fluorescence emission at 442 nm and 469 nm, respectively. Compounds 1 and 2 in CH2Cl2 reveal broad emission band characteristics of the Ir(III)/dfppy(-) chromophores at 508 nm and 494 nm, respectively, with a mixing of (3)MLCT and (3)LC characters. At room temperature, the photochromism ability of L2H in CH2Cl2 is clearly weaker than that of L1H. Moreover, no photochromism has been observed in 1 and 2. It has been demonstrated that both the substituent group and {Ir(dfppy)2}(+) coordination could significantly influence the crystal structures, luminescence and photochromic properties of L1H, L2H, 1 and 2. PMID:25635520

  15. Volumetric Behaviour of the (2,2,4-Trimethylpentane + Methylbenzene + Butan-1-ol) Ternary System and Its Binary Sub-Systems within the Temperature Range (298.15–328.15) K

    Morávková, L. (Lenka); Troncoso, J.; Machanová, K. (Karolina); Sedláková, Z.

    2013-01-01

    Densities and speeds of sound of the (2,2,4-trimethylpentane + methylbenzene + butan-1-ol) ternary system as well as all its binary sub-systems were measured at four temperatures, namely 298.15 K, 308.15 K, 318.15 K, and 328.15 K at atmospheric pressure by a vibrating-tube densimeter DSA 5000. The binary (isooctane + toluene) system was studied previously. Excess quantities (molar volume, adiabatic compressibility, and isobaric thermal expansivity) of the mixtures studied were calculated from...

  16. Study of Dynamical $K/\\pi$ and $p/\\pi$ Fluctuations in $\\sqrt{s_{NN}}$ = 22.4 GeV Cu+Cu Collisions from the STAR Experiment

    Tarnowsky, Terence J

    2010-01-01

    Results from the measurement of dynamical $K/\\pi$ and $p/\\pi$ ratio fluctuations are presented. Dynamical fluctuations in global conserved quantities such as baryon number, strangeness, or charge may be observed near a QCD critical point. The first measurement of results of $K/\\pi$ and $p/\\pi$ fluctuations from Cu+Cu collisions at an energy $\\sqrt{s_{NN}}$ = 22.4 GeV are shown. This energy range is close to the top SPS energy and has garnered additional interest due to the proposed QCD critical point search at RHIC. The new Cu+Cu data is compared to previous results from Au+Au collisions at the energies $\\sqrt{s_{NN}}$ = 19.6, 62.4, 130, and 200 GeV, and to measurements from the NA49 experiment. The dynamical $K/\\pi$ fluctuation results from Cu+Cu at $\\sqrt{s_{NN}}$ = 22.4 GeV are in good agreement with previous measurements from the STAR and NA49 experiments near that energy. Results are compared to theoretical predictions from several models including the HIJING and UrQMD models.

  17. Synthesis, antifungal activities and molecular docking studies of novel 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates.

    Zou, Yan; Yu, Shichong; Li, Renwu; Zhao, Qingjie; Li, Xiang; Wu, Maocheng; Huang, Ting; Chai, Xiaoxun; Hu, Honggang; Wu, Qiuye

    2014-03-01

    A series of 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates as new analogs of fluconazole were synthesized and their antifungal activities were evaluated. Among these compounds, 2a-f and 3a-q exhibited higher activities than fluconazole against nearly all fungi tested except Aspergillus fumigatus. Noticeably, the in vitro biological activities of 2b, 3a, 3c, 3h-k, and 3o-q against Candida species were much better than those of fluconazole and ketoconazole. Also, 2a-d, 3a-d, 3e-f, 3h-k, 3p and 3q showed higher activities against A. fumi than fluconazole. Computational docking experiments indicated that the inhibition of CYP51 involved a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft. PMID:24487187

  18. Support vector classification for structure-activity-relationship of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols%支持向量分类算法用于1-(1H-1,2,4-三唑-1-基)-2-(2,4-二氟苯基)-3-取代-2-丙醇化合物的构效关系研究

    纪晓波; 陆文聪; 蔡煜东; 陈念贻

    2007-01-01

    The support vector classification (SVC) was employed to make a model for classification of antifungal activities of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols triazole derivatives. The compounds with high antifungal activities and those with low antifungal activities were compared on the basis of the following molecular descriptors: net atomic charge on the atom N connecting with R, dipole moment and heat of formation. By using the SVC, a mathematical model was constructed, which can predict the antifungal activities of the triazole derivatives, with an accuracy of 91% on the basis of the leave-one-out cross-validation (LOOCV) test. The results indicate that the performance of the SVC model can exceed that of the principal component analysis (PCA) and K-Nearest Neighbor (KNN) models for this real world data set.

  19. Microstructural characterization during the hot deformation of 1.17C-11.3Cr-1.48V-2.24W-1.35Mo ledeburitic tool steel

    Vecko Pirtovsek, T.; Kugler, G. [Faculty of Natural Sciences and Engineering University of Ljubljana, Ljubljana (Slovenia); Godec, M. [Institite of Metals and Technology, Ljubljana (Slovenia); Tercelj, M., E-mail: Milan.Tercelj@ntf.uni-lj.si [Faculty of Natural Sciences and Engineering University of Ljubljana, Ljubljana (Slovenia)

    2011-02-15

    The hot-deformation behavior of 1.17C-11.3Cr-1.48V-2.24W-1.35Mo tool steel was studied. Hot-compression tests were carried out in the temperature range of 850-1200 {sup o}C, at strain rates in the range of 0.001-6 s{sup -1}, and field-emission scanning electron microscope and optical microscopy were used for the microstructural characterization, which revealed a very complex precipitation of carbides that depends on the soaking temperature, the soaking time, the stress state, the deformation temperature as well as on the strain rate. A procedure for determining an appropriate soaking temperature, which enables an extension of the safe hot-working range, was developed. The soaking temperature and the time are the key factors controlling the hot workability. A study of the dissolution of ledeburitic carbides showed that there is a limit fraction to which the carbides could be dissolved prior to hot working without any negative influence on the hot workability. A revision of the general opinion about the influence of non-dissolved carbides on the hot workability is given. - Research Highlights: {yields} Procedure for determining of optimal soaking temperature is given. {yields} Apparent activation energies for three temperature and strain rate ranges are given. {yields} And Q at lower T and are increased due to higher amount of secondary carbides. {yields} Optimal fraction of dissolved carbides prior deformation increases hot workability.

  20. Microstructural characterization during the hot deformation of 1.17C-11.3Cr-1.48V-2.24W-1.35Mo ledeburitic tool steel

    The hot-deformation behavior of 1.17C-11.3Cr-1.48V-2.24W-1.35Mo tool steel was studied. Hot-compression tests were carried out in the temperature range of 850-1200 oC, at strain rates in the range of 0.001-6 s-1, and field-emission scanning electron microscope and optical microscopy were used for the microstructural characterization, which revealed a very complex precipitation of carbides that depends on the soaking temperature, the soaking time, the stress state, the deformation temperature as well as on the strain rate. A procedure for determining an appropriate soaking temperature, which enables an extension of the safe hot-working range, was developed. The soaking temperature and the time are the key factors controlling the hot workability. A study of the dissolution of ledeburitic carbides showed that there is a limit fraction to which the carbides could be dissolved prior to hot working without any negative influence on the hot workability. A revision of the general opinion about the influence of non-dissolved carbides on the hot workability is given. - Research Highlights: → Procedure for determining of optimal soaking temperature is given. → Apparent activation energies for three temperature and strain rate ranges are given. → And Q at lower T and are increased due to higher amount of secondary carbides. → Optimal fraction of dissolved carbides prior deformation increases hot workability.

  1. Participant and spectator scaling of spectator fragments in Au + Au and Cu + Cu collisions at √{sN N}=19.6 and 22.4 GeV

    Alver, B.; Back, B. B.; Baker, M. D.; Ballintijn, M.; Barton, D. S.; Betts, R. R.; Bickley, A. A.; Bindel, R.; Budzanowski, A.; Busza, W.; Carroll, A.; Chai, Z.; Chetluru, V.; Decowski, M. P.; García, E.; Gburek, T.; George, N.; Gulbrandsen, K.; Gushue, S.; Halliwell, C.; Hamblen, J.; Harnarine, I.; Heintzelman, G. A.; Henderson, C.; Hofman, D. J.; Hollis, R. S.; Hołyński, R.; Holzman, B.; Iordanova, A.; Johnson, E.; Kane, J. L.; Katzy, J.; Khan, N.; Kucewicz, W.; Kulinich, P.; Kuo, C. M.; Li, W.; Lin, W. T.; Loizides, C.; Manly, S.; McLeod, D.; Mignerey, A. C.; Nouicer, R.; Olszewski, A.; Pak, R.; Park, I. C.; Pernegger, H.; Reed, C.; Remsberg, L. P.; Reuter, M.; Richardson, E.; Roland, C.; Roland, G.; Rosenberg, L.; Sagerer, J.; Sarin, P.; Sawicki, P.; Sedykh, I.; Skulski, W.; Smith, C. E.; Stankiewicz, M. A.; Steinberg, P.; Stephans, G. S. F.; Sukhanov, A.; Szostak, A.; Tang, J.-L.; Tonjes, M. B.; Trzupek, A.; Vale, C.; van Nieuwenhuizen, G. J.; Vaurynovich, S. S.; Verdier, R.; Veres, G. I.; Walters, P.; Wenger, E.; Willhelm, D.; Wolfs, F. L. H.; Wosiek, B.; Woźniak, K.; Wuosmaa, A. H.; Wyngaardt, S.; Wysłouch, B.; Phobos Collaboration

    2016-08-01

    Spectator fragments resulting from relativistic heavy ion collisions, consisting of single protons and neutrons along with groups of stable nuclear fragments up to nitrogen (Z =7 ), are measured in PHOBOS. These fragments are observed in Au+Au (√{sNN}=19.6 GeV ) and Cu+Cu (22.4 GeV) collisions at high pseudorapidity (η ). The dominant multiply-charged fragment is the tightly bound helium (α ), with lithium, beryllium, and boron all clearly seen as a function of collision centrality and pseudorapidity. We observe that in Cu+Cu collisions, it becomes much more favorable for the α fragments to be released than lithium. The yields of fragments approximately scale with the number of spectator nucleons, independent of the colliding ion. The shapes of the pseudorapidity distributions of fragments indicate that the average deflection of the fragments away from the beam direction increases for more central collisions. A detailed comparison of the shapes for α and lithium fragments indicates that the centrality dependence of the deflections favors a scaling with the number of participants in the collision.

  2. Participant and spectator scaling of spectator fragments in Au+Au and Cu+Cu collisions at sqrt(sNN) = 19.6 and 22.4 GeV

    Alver, B; Baker, M D; Ballintijn, M; Barton, D S; Betts, R R; Bickley, A A; Bindel, R; Budzanowski, A; Busza, W; Carroll, A; Chai, Z; Chetluru, V; Decowski, M P; Garcia, E; Gburek, T; George, N; Gulbrandsen, K; Gushue, S; Halliwell, C; Hamblen, J; Harnarine, I; Heintzelman, G A; Henderson, C; Hofman, D J; Hollis, R S; Holynski, R; Holzman, B; Iordanova, A; Johnson, E; Kane, J L; Katzy, J; Khan, N; Kucewicz, W; Kulinich, P; Kuo, C M; Li, W; Lin, W T; Loizides, C; Manly, S; McLeod, D; Mignerey, A C; Nouicer, R; Olszewski, A; Pak, R; Park, I C; Pernegger, H; Reed, C; Remsberg, L P; Reuter, M; Richardson, E; Roland, C; Roland, G; Rosenberg, L; Sagerer, J; Sarin, P; Sawicki, P; Sedykh, I; Skulski, W; Smith, C E; Stankiewicz, M A; Steinberg, P; Stephans, G S F; Sukhanov, A; Szostak, A; Tang, J L; Tonjes, M B; Trzupek, A; Vale, C; van Nieuwenhuizen, G J; Vaurynovich, S S; Verdier, R; Veres, G I; Walters, P; Wenger, E; Willhelm, D; Wolfs, F L H; Wosiek, B; Wozniak, K; Wuosmaa, A H; Wyngaardt, S; Wyslouch, B

    2015-01-01

    Spectator fragments resulting from relativistic heavy ion collisions, consisting of single protons and neutrons along with groups of stable nuclear fragments up to Nitrogen (Z=7), are measured in PHOBOS. These fragments are observed in Au+Au (sqrt(sNN)=19.6 GeV) and Cu+Cu (22.4 GeV) collisions at high pseudorapidity ($\\eta$). The dominant multiply-charged fragment is the tightly bound Helium ($\\alpha$), with Lithium, Beryllium, and Boron all clearly seen as a function of collision centrality and pseudorapidity. We observe that in Cu+Cu collisions, it becomes much more favorable for the $\\alpha$ fragments to be released than Lithium. The yields of fragments approximately scale with the number of spectator nucleons, independent of the colliding ion. The shapes of the pseudorapidity distributions of fragments indicate that the average deflection of the fragments away from the beam direction increases for more central collisions. A detailed comparison of the shapes for $\\alpha$ and Lithium fragments indicates tha...

  3. Inclusive production of pπ+ and pπ- systems in anti pp collisions at 22.4 GeV/c and one-pion exchange model

    An analysis of inclusive production of pπ+ and pπ- pairs in the anti pp → pπX reaction in the proton fragmentation region was carried out in the framework of the one-pion exchange model. A liquid hydrogen bubble chamber was exposed in the antiproton beam at 22.4 GeV/c. Approximately 18000 inelastic events were processed. This is the first description of the nonresonance spectrum of pπ+- systems. The main features of the reactions are as follows: mass distributions, x distributions, distributions in transverse momenta and 4-momentum and angular distributions in the pπ+ and pπ- decays; they are shown the be described by the model satisfactorily well. The Δ++ (1236) isobar production cross section of approximately 1 mb calculated in the model, constitutes approximately 50% of the experimentaly measured cross section. The average values of spherical functions in th Δ-isobar region and in the neighbouring regions are shown to be drastically different. This difference is attributed to the background combination contributions. Allowance for the background diagrams improves substantially the agreement with the experiment, in particular for pπ- systems

  4. 1:1 and 2:1 Lithium Zincates with Intramolecular Coordination. Structures of Li(thf)Zn(C6H4CH2NMe2-2)3 and Li2Zn(C6H4CH2NMe2-2)4

    van Koten, G; Rijnberg, E.; Jastrzebski, J.T.B.H.; Boersma, J.; Kooijman, H.; Veldman, N.; Spek, A.L.

    1997-01-01

    Homoleptic lithium zincates with intramolecular Li-N coordination, i.e., Li(thf)nZn(C6H4CH2NMe2-2)3 (n = 0 (1); n = 1 (1(thf))) and Li2Zn(C6H4CH2NMe2-2)4 (2) have been prepared by reacting [Li(C6H4CH2NMe2-2)]4 with Zn(C6H4CH2NMe2-2)2. In the solid state 1(thf) is a monomer containing a distorted tetrahedral zinc atom. The zinc is surrounded by three monoanionic C6H4CH2NMe2-2 (dmba) ligands, which all show a different bonding mode: 1-C bonding to zinc and nitrogen coordination to lithium; 1,2-...

  5. INDEPENDENT VERIFICATION SURVEY REPORT FOR EXPOSURE UNITS Z2-24, Z2-31, Z2-32, AND Z2-36 IN ZONE 2 OF THE EAST TENNESSEE TECHNOLOGY PARK OAK RIDGE, TENNESSEE

    None

    2013-10-10

    The U.S. Department of Energy (DOE) Oak Ridge Office of Environmental Management selected Oak Ridge Associated Universities (ORAU), through the Oak Ridge Institute for Science and Education (ORISE) contract, to perform independent verification (IV) at Zone 2 of the East Tennessee Technology Park (ETTP) in Oak Ridge, Tennessee. ORAU has concluded IV surveys, per the project-specific plan (PSP) (ORAU 2013a) covering exposure units (EUs) Z2-24, -31, -32, and -36. The objective of this effort was to verify the following. • Target EUs comply with requirements in the Zone 2 Record of Decision (ROD) (DOE 2005), as implemented by using the dynamic verification strategy presented in the dynamic work plan (DWP) (BJC 2007) • Commitments in the DWP were adequately implemented, as verified via IV surveys and soil sampling The Zone 2 ROD establishes maximum remediation level (RLmax) values and average RL (RLavg) values for the primary contaminants of concern (COCs) U-234, U-235, U-238, Cs-137, Np-237, Ra-226, Th-232, arsenic, mercury, and polychlorinated biphenyls (PCBs). Table 1.1 lists Zone 2 COCs with associated RLs. Additional radiological and chemical contaminants were also identified during past characterization and monitoring actions, though the ROD does not present RLs for these potential contaminants. IV activities focused on the identification and quantification of ROD-specific COCs in surface soils, but also generated data for other analytes to support future decisions. ORAU personnel also reviewed EU-specific phased construction completion reports (PCCRs) to focus IV activities and identify potential judgmental sample locations, if any.

  6. Catalytic performance of Fe3O4-CoO/Al2O3 catalyst in ozonation of 2-(2,4-dichlorophenoxy) propionic acid,nitrobenzene and oxalic acid in water

    Shaoping Tong; Rui Shi; Hua Zhang; Chunan Ma

    2010-01-01

    the precursors,and its catalytic performance was investigated in ozonation of 2-(2,4-dichlorophenoxy) propionic acid (2,4-DP),nitrobenzene and oxalic acid.The experimental results indicated that Fe3O4-CoO/Al2O3 catalyst enabled an interesting improvement of ozonation efficiency during the degradation of each organic pollutant,and the Fe3O4-CoO/Al2O3 catalytic ozonation system followed a radical-type mechanism.The kinetics of ozonation alone and Fe3O4-CoO/Al2O3 catalytic ozonation of three organic pollutants in aqueous solution were discussed under the mere consideration of direct ozone reaction and OH radical reaction to well investigate its performance.In the catalytic ozonation of 2,4-DP,the apparent reaction rate constants (k) were determined to be 1.456×10-2 min-1 for ozonation alone and 4.740×10-2 min-1 for O3/Fe3O4-CoO/Al2O3.And O3/Fe3O4-CoO/Al2O3 had a larger Rct (6.614×10-9) calculated by the relative method than O3 did (1.800×10-9),showing O3/Fe3O4-CoO/Al2O3 generated more hydroxyl radical.Similar results were also obtained in the catalytic ozonation of nitrobenzene and oxalic acid.The above results demonstrated that the catalytic performance of Fe3O4-CoO/Al2O3 in ozonation of studied organic substance was universal to a certain degree.

  7. 49 CFR 224.5 - Definitions.

    2010-10-01

    ... Administrator's delegate. Damaged means scratched, broken, chipped, peeled, or delaminated. Flat car means a car...); and (2) Any railroad freight car (whether used in revenue or work train service). Freight rolling... following: A railroad; a manager, supervisor, official, or other employee or agent of a railroad; any...

  8. 22 CFR 224.33 - Witnesses.

    2010-04-01

    ....33 Witnesses. (a) Except as provided in paragraph (b) of this section, testimony at the hearing shall be given orally by witnesses under oath or affirmation. (b) At the discretion of the ALJ, testimony... provided to all other parties along with the last known address of such witness, in a manner which...

  9. 31 CFR 800.224 - Transaction.

    2010-07-01

    ... merger, acquisition, or takeover. It includes: (a) The acquisition of an ownership interest in an entity. (b) The acquisition or conversion of convertible voting instruments of an entity. (c) The acquisition of proxies from holders of a voting interest in an entity. (d) A merger or consolidation. (e)...

  10. CopperCore 2.2.4

    Vogten, Hubert; Martens, Harrie; Koper, Rob

    2005-01-01

    Changed in this release: -fixed bug with the id of the Monitor object and other services, fixed bugs with regard to the visibility of items. Please go to SourceForge for the original sources and website (this is only a backup archive): http://coppercore.sourceforge.net/ Available under the GNU GPL l

  11. Bestimmung der Ionisationsenergie von Actinium und Ultraspurenanalyse von Plutonium mit resonanter Ionisationsmassenspektrometrie (RIMS)

    Waldek, Achim Marcus

    2001-01-01

    ZusammenfassungDie Resonanzionisationsmassenspektrometrie (RIMS) verbindet hohe Elementselektivität mit guter Nachweiseffizienz. Aufgrund dieser Eigenschaften ist die Methode für Ultraspurenanalyse und Untersuchungen an seltenen oder schwer handhabbaren Elementen gut geeignet. Für RIMS werden neutrale Atome mit monochromatischem Laserlicht ein- oder mehrfach resonant auf energetisch hoch liegende Niveaus angeregt und anschließend durch einen weiteren Laserstrahl oder durch ein elektrisches Fe...

  12. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228

    The activities of 228Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide 228Ac. The radium was pre-concentrated on MnO2 and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter 228Ra(228Ac), the daughter nuclide 228Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by 228Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9±0.1% was measured for 228Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317±0.013 cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1 g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of 228Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for 228Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure 228Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used

  13. Linear free energy relationship applied to trivalent cations with lanthanum and actinium oxide and hydroxide structure

    Linear free energy relationships for trivalent cations with crystalline M2O3 and, M(OH)3 phases of lanthanides and actinides were developed from known thermodynamic properties of the aqueous trivalent cations, modifying the Sverjensky and Molling equation. The linear free energy relationship for trivalent cations is as ΔGf,MvX0=aMvXΔGn,M3+0+bMvX+βMvXrM3+, where the coefficients aMvX, bMvX, and βMvX characterize a particular structural family of MvX, rM3+ is the ionic radius of M3+ cation, ΔGf,MvX0 is the standard Gibbs free energy of formation of MvX and ΔGn,M3+0 is the standard non-solvation free energy of the cation. The coefficients for the oxide family are: aMvX=0.2705, bMvX=-1984.75 (kJ/mol), and βMvX=197.24 (kJ/molnm). The coefficients for the hydroxide family are: aMvX=0.1587, bMvX=-1474.09 (kJ/mol), and βMvX=791.70 (kJ/molnm).

  14. Actinium: A RESTful Runtime Container for Scriptable Internet of Things Applications

    Kovatsch, Matthias; Lanter, Martin; Duquennoy, Simon

    2012-01-01

    Programming Internet of Things (IoT) applications is challenging because developers have to be knowledgeable in various technical domains, from low-power networking, over embedded operating systems, to distributed algorithms. Hence, it will be challenging to find enough experts to provide software for the vast number of expected devices, which must also be scalable and particularly safe due to the connection to the physical world. To remedy this situation, we propose an architecture that pr...

  15. New method for large scale production of medically applicable Actinium-225 and Radium-223

    Alpha-emitters (211At, 212Bi, 213Bi, 223Ra, 225Ac) are promising for targeted radiotherapy of cancer. Only two alpha decays near a cell membrane result in 50% death of cancer cell and only a single decay inside the cell is required for this. 225Ac may be used either directly or as a mother radionuclide in 213Bi isotope generator. Production of 225Ac is provided by three main suppliers - Institute for Transuranium Elements in Germany, Oak Ridge National Laboratory in USA and Institute of Physics and Power Engineering in Obninsk, Russia. The current worldwide production of 225Ac is approximately 1.7 Ci per year that corresponds to only 100-200 patients that could be treated annually. The common approach for 225Ac production is separation from mother 229Th or irradiation of 226Ra with protons in a cyclotron. Both the methods have some practical limitations to be applied routinely. 225Ac can be also produced by irradiation of natural thorium with medium energy protons . Cumulative cross sections of 225Ac, 227Ac, 227Th, 228Th formations have been obtained recently. Thorium targets (1-9 g) were irradiated by 114-91 MeV proton beam (1-50 μA) at INR linear accelerator. After dissolution in 8 M HNO3 + 0.004 M HF thorium was removed by double LLX by HDEHP in toluene (1:1). Ac and REE were pre-concentrated and separated from Ra and most fission products by DGA-Resin (Triskem). After washing out by 0.01 M HNO3 Ac was separated from REE by TRU Resin (Triskem) in 3 M HNO3 media. About 6 mCi 225Ac were separated in hot cell with chemical yield 85%. The method may be upscaled for production of Ci amounts of the radionuclide. The main impurity is 227Ac (0.1% at the EOB) but it does not hinder 225Ac from being used for medical 225Ac/213Bi generators. (author)

  16. Synthesis of chelating agents for actinium 225 complexation and its application in radioimmunotherapy

    Immunotherapy with radiolabeled antibodies should allow fairly specific targeting of certain cancers. However, iodine 131 may not be the best isotope for tumor therapy because of its limited specific activity, low beta-energy, relatively long half life and strong gamma emission. Another approach to improve therapeutic efficacy is the use of replacement isotopes with better physical properties. Chelator that can hold radio-metals with high stability under physiological conditions are essential to avoid excessive damage to non-target cells; Moreover, the development of new bifunctional chelating agents is essential for this purpose. Accordingly, our efforts have been directed, for several years, to the synthesis of original chelating agents likely to form stable complexes in vivo with the numerous potential candidates for such applications. Therefore, we have developed a new simple and efficient synthesis pathway of 2-(4-iso-thio-cyanate-benzyl)-1,4,7,10,13,16- hexa-aza-cyclo-hexadecane- 1,4,7,10,13,16-hexa-acetic acid, though functionalized on the cycle by a termination allowed coupling to an antibody or any other biological substance such as a hapten. (author)

  17. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    A technique of selenium purification from 232Th, 238U, 226,228Ra, 227Ac and 40K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  18. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    Rakhimov, A.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz); Warot, G. [CEA-CNRS, Modane (France). Laboratoire Souterrain de Modane (LSM); Karaivanov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Institute for Nuclear Research and Nuclear Energy (INRNE), Sofia (Bulgaria); Kochetov, O.I.; Lebedev, N.A.; Filosofov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Mukhamedshina, N.M.; Sadikov, I.I. [Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz)

    2013-07-01

    A technique of selenium purification from {sup 232}Th, {sup 238}U, {sup 226,228}Ra, {sup 227}Ac and {sup 40}K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  19. 49 CFR 571.224 - Standard No. 224; Rear impact protection.

    2010-10-01

    ... deliver asphalt and other road building materials, in a controlled horizontal manner, into a lay down... trailers, pulpwood trailers, road construction controlled horizontal discharge trailers, special purpose... motor vehicle, as defined in 49 CFR 171.8, is certified to carry hazardous materials and has a...

  20. The identification of soil radionuclides in the area of Puspiptek and surrounding

    The area of PUSPIPTEK and the surrounding are potentially exposed by radionuclides, because the operation of the nuclear research plant. The PPTN Serpong was operated long than 10 years, therefore soil radioactivity need to evaluate. The determination of radioactivity in the soil samples which be taken from research location using gamma spectrometry on June-August. The result of the research identified natural radionuclides K-40; Thorium decay series Ac-228, Bi-212, Pb-212, Tl-208, Ra-224 and Rn-220; Uranium decay series Bi-214, Pa-234, Pb-214 and Actinium decay series Bi-211, Po-211. There are no identification radionuclides produce from the activation of PPTN Serpong

  1. Excess enthalpies of ternary mixtures of oxygenated additives + hydrocarbon mixtures in fuels and bio-fuels: Dibutyl ether (DBE) and 1-butanol and 1-hexene or cyclohexane or 2,2,4 trimethylpentane at 298.15 K and 313.15 K

    Highlights: ► New excess enthalpy data for ternary mixtures of dibutyl ether + hydrocarbon + 1-butanol are reported. ► Four ternary systems at 298.15 K and 313.15 K were measured by means of an isothermal flow calorimeter. ► 420 Data were fitted to a Redlich–Kister rational equation. ► Intermolecular and association effects involved in these systems have been discussed. - Abstract: New experimental excess molar enthalpy data (420 points) of the ternary systems dibutyl ether (DBE) and 1-butanol and 1-hexene at 298.15 K and 313.15 K, and DBE and 1-butanol and cyclohexane or 2,2,4-trimethylpentane (TMP) at 313.15 K at atmospheric pressure are reported. A quasi-isothermal flow calorimeter has been used to make the measurements. All the ternary systems show endothermic character. The experimental data for the ternary systems have been fitted using the Redlich–Kister rational equation. Considerations with respect the intermolecular interactions amongst ether, alcohol and hydrocarbon compounds are presented.

  2. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  3. Dicty_cDB: SSL224 [Dicty_cDB

    Full Text Available ERINE/THREONINE-PROTEIN KINASE C07A9.3 IN CHROMOSOME III ;, mRNA sequence. 46 0.31 1 BH523732 |BH523732.1 BOGMG03TF BOGM... Brassica oleracea genomic clone BOGMG03, DNA sequence. 46 0.31 1 AX713881 |AX713881.1 Sequence

  4. Editorial [Malta Medical Journal, Vol.22(4)

    Vassallo, Josanne

    2010-01-01

    Another publication year has come to an end and I note with pleasure the diversity of papers that have been submitted over the course of the past year. The papers are of particular interest to the medical community in the Maltese islands. A survey dealing with the aetiology of infectious intestinal disease provides information of relevance to practitioners in Malta.

  5. 4 CFR 22.4 - Appeal File [Rule 4].

    2010-01-01

    .... Numbering of pages shall be consecutive and continuous from one page to the next (i.e., “Bates” numbered... alternative organization of the appeal file is permitted, such as by document type or topic, documents...

  6. Organizing to Work with CETA. Information Series No. 224.

    Jacobson, Thomas J.

    This paper traces Comprehensive Employment and Training Act (CETA) vocational education coordination activities that have occurred in the past and provides suggestions for activities that can be pursued at the local school district level to help school districts participate in the funding opportunities available under CETA. It is designed for…

  7. Dicty_cDB: CHE224 [Dicty_cDB

    Full Text Available SDVKFLNTPHFELPPNANPGDFLR ETFDHPSAPKALEFAHGTTTLAFVYGGGIIVSXDSKSTQGPY--- ---rthlccccx*nfskxxifi*rxrfingxydywlg...*nwtxiilc***wd*itwstffm wxrfnxxlwcfxxrf*mgye*xxsi*trsxsclscnsqxxllwwxyqclscskrwle...fkyttfrittkcksr*ffkr ni*ssistksigictwynyisiciwwryycixrfkiytrtir--- ---nssllllhxkf*qxlxihikxtvyqwxl*llvgikldx...nyimlimmgldymvnvfhv xqvqxmxmvfxxqvlngi*mxxkhmnsvxxlfimqltxxltlvxlsmfimfkkmvgxrfl lmixsnxixnitilxqlinqxn*xqxl

  8. 29 CFR 553.224 - “Work period” defined.

    2010-07-01

    ... Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS APPLICATION... and is not designed to evade the overtime compensation requirements of the Act. (b) An employer may... regularly recurring period of work which, under the terms of the Act and legislative history, cannot be...

  9. 7 CFR 2.24 - Assistant Secretary for Administration.

    2010-01-01

    ... health services and related functions. (ii) Operating centralized Departmental services to provide... of promotion” cases in the excepted service where not in accordance with time-in-grade criteria; (I...) Hours of duty; (G) Performance management; (H) Promotions; (I) Employee development; (J)...

  10. Dicty_cDB: AFO224 [Dicty_cDB

    Full Text Available ksck*ey snr*slrftrketllqsw*t*cscp*t*lcrpir*syrkrsfithllwyskw*fcnfthc wcsswyrn*thr*w*nyn*rccwssns*ilftnfrei...ki*ni Frame B: fkknhlgnlkifnikk*kksflttfvyaeekkrnekyiiirfwlcckast*lplkkrrlf cnnc*fi

  11. 22 CFR 224.27 - Computation of time.

    2010-04-01

    ... government, in which event it includes the next business day. (b) When the period of time allowed is less than seven days, intermediate Saturdays, Sundays, and legal holidays observed by the Federal...

  12. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the success of {sup 225}Ac radioimmunotherapy.

  13. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  14. Distribution of trace elements in land plants and botanical taxonomy with special reference to rare earth elements and actinium

    Distribution profiles of trace elements in land plants were studied by neutron activation analysis and radioactivity measurements without activation. Number of botanical samples analyzed were more than three thousand in which more than three hundred botanical species were included. New accumulator plants of Co, Cr, Zn, Cd, rare earth elements, Ac, U, etc., were found. Capabilities of accumulating trace elements can be related to the botanical taxonomy. Discussions are given from view points of inorganic chemistry as well as from botanical physiology

  15. 抑郁症状与伤害发生特点的相关分析--基于1224例农村女性的横断面调查%A Cross-sectional Survey on the Correlation between Depressive Symptoms and Characteristics of Injury based on 1 224 Rural Women

    帅健; 李丽萍; 方瑶; 陈业群; 熊建平; 张艳

    2013-01-01

    Objective To describe the occurrence of depressive symptoms and injury among rural women, and to explore the relationship between depressive symptoms and epidemiological characteristics of injury. Methods The study sample which was 1 224 rural women more than 18 years, from 22 places of Chaoshan district (Shantou, Chaozhou and Jieyang) of Guangdong province was got by cluster random sampling and investigated by Injuries information form and CES-D. The collected data was used to analyse the influence factors of depressive symptoms and the characters of injury through means of Chi-square test. Results Incidence of injuries was 8.01%, detection rate of depressive symptoms was 23.04%. The difference with respect to the quantity of samples with injuries did not have a statistical significance in different regions(P>0.05),but did in different age groups , states of marriage, occupation and education level(P0.05), but did in different states of marriage, occupation and education level(P0.05);未婚女性检出率(42.31%)、家务/离退休女性抑郁检出率(27.63%)、未接受教育女性的抑郁检出率(29.20%)较高,差异均有统计学意义(P<0.05)。有抑郁倾向组与无抑郁组在受伤种类、受伤性质、伤后处理和住院情况之间有差异。受伤性质中,有抑郁倾向组以骨折(40.00%)为主,无抑郁组为浅表损伤(50.60%);伤后处理中,有抑郁倾向组以门诊(40.00%)为主,无抑郁组为自己处理(32.53%);有抑郁倾向组严重伤害发生率(住院率46.67%)高于非抑郁组(6.02%)。结论农村女性表现出较高的伤害发生率和抑郁症状检出率,抑郁症状与伤害发生特点有一定的关联,应针对其特征采取相应的措施,促进农村女性的身心健康。

  16. Validation of MIPAS IMK/IAA V5R_O3_224 ozone profiles

    A. Laeng

    2014-04-01

    Full Text Available We present the results of an extensive validation program of the most recent version of ozone vertical profiles retrieved with the IMK/IAA MIPAS research level 2 processor from version 5 spectral Level 1 data. The time period covered corresponds to the reduced spectral resolution period of the MIPAS instrument, i.e. January 2005–April 2012. The comparison with satellite instruments includes all post-2005 satellite limb and occultation sensors having measured the vertical profiles of tropospheric and stratospheric ozone: ACE-FTS, GOMOS, HALOE, HIRDLS, MLS, OSIRIS, POAM, SAGE II, SCIAMACHY, SMILES, and SMR. In addition, balloon-borne MkIV solar occultation measurements and groundbased Umkehr measurements have been included, as well as two nadir sensors: IASI and SBUV. For each reference dataset, bias determination and precision assessment are performed. Better agreement with reference instruments than for the previous data version, V5R_O3_220 (Laeng et al., 2013, is found: the known high bias around the ozone vmr peak is significantly reduced and the vertical resolution at 35 km has been improved. The agreement with limb and solar occultation reference instruments that have a known small bias vs. ozone sondes is within 7% in the lower and middle stratosphere and 5% in the upper troposphere. Around the ozone vmr peak, the agreement with most of satellite reference instruments is within 5%; this bias is as low as 3% for ACE-FTS, MLS, OSIRIS, POAM and SBUV.

  17. Validation of MIPAS IMK/IAA V5R_O3_224 ozone profiles

    Laeng, A.; Grabowski, U.; von Clarmann, T.; Stiller, G.; Glatthor, N.; Höpfner, M.; Kellmann, S.; Kiefer, M.; Linden, A.; Lossow, S.; Sofieva, V.; Petropavlovskikh, I.; Hubert, D.; Bathgate, T.; Bernath, P.; Boone, C. D.; Clerbaux, C.; Coheur, P.; Damadeo, R.; Degenstein, D.; Frith, S.; Froidevaux, L.; Gille, J.; Hoppel, K.; McHugh, M.; Kasai, Y.; Lumpe, J.; Rahpoe, N.; Toon, G.; Sano, T.; Suzuki, M.; Tamminen, J.; Urban, J.; Walker, K.; Weber, M.; Zawodny, J.

    2014-11-01

    We present the results of an extensive validation program of the most recent version of ozone vertical profiles retrieved with the IMK/IAA (Institute for Meteorology and Climate Research/Instituto de Astrofísica de Andalucía) MIPAS (Michelson Interferometer for Passive Atmospheric Sounding) research level 2 processor from version 5 spectral level 1 data. The time period covered corresponds to the reduced spectral resolution period of the MIPAS instrument, i.e., January 2005-April 2012. The comparison with satellite instruments includes all post-2005 satellite limb and occultation sensors that have measured the vertical profiles of tropospheric and stratospheric ozone: ACE-FTS, GOMOS, HALOE, HIRDLS, MLS, OSIRIS, POAM, SAGE II, SCIAMACHY, SMILES, and SMR. In addition, balloon-borne MkIV solar occultation measurements and ground-based Umkehr measurements have been included, as well as two nadir sensors: IASI and SBUV. For each reference data set, bias determination and precision assessment are performed. Better agreement with reference instruments than for the previous data version, V5R_O3_220 (Laeng et al., 2014), is found: the known high bias around the ozone vmr (volume mixing ratio) peak is significantly reduced and the vertical resolution at 35 km has been improved. The agreement with limb and solar occultation reference instruments that have a known small bias vs. ozonesondes is within 7% in the lower and middle stratosphere and 5% in the upper troposphere. Around the ozone vmr peak, the agreement with most of the satellite reference instruments is within 5%; this bias is as low as 3% for ACE-FTS, MLS, OSIRIS, POAM and SBUV.

  18. Validation of MIPAS IMK/IAA V5R_O3_224 ozone profiles

    A. Laeng

    2014-11-01

    Full Text Available We present the results of an extensive validation program of the most recent version of ozone vertical profiles retrieved with the IMK/IAA (Institute for Meteorology and Climate Research/Instituto de Astrofísica de Andalucía MIPAS (Michelson Interferometer for Passive Atmospheric Sounding research level 2 processor from version 5 spectral level 1 data. The time period covered corresponds to the reduced spectral resolution period of the MIPAS instrument, i.e., January 2005–April 2012. The comparison with satellite instruments includes all post-2005 satellite limb and occultation sensors that have measured the vertical profiles of tropospheric and stratospheric ozone: ACE-FTS, GOMOS, HALOE, HIRDLS, MLS, OSIRIS, POAM, SAGE II, SCIAMACHY, SMILES, and SMR. In addition, balloon-borne MkIV solar occultation measurements and ground-based Umkehr measurements have been included, as well as two nadir sensors: IASI and SBUV. For each reference data set, bias determination and precision assessment are performed. Better agreement with reference instruments than for the previous data version, V5R_O3_220 (Laeng et al., 2014, is found: the known high bias around the ozone vmr (volume mixing ratio peak is significantly reduced and the vertical resolution at 35 km has been improved. The agreement with limb and solar occultation reference instruments that have a known small bias vs. ozonesondes is within 7% in the lower and middle stratosphere and 5% in the upper troposphere. Around the ozone vmr peak, the agreement with most of the satellite reference instruments is within 5%; this bias is as low as 3% for ACE-FTS, MLS, OSIRIS, POAM and SBUV.

  19. Methyl (Z-2-[(2,4-dioxothiazolidin-3-ylmethyl]-3-(2-methylphenylprop-2-enoate

    S. Vijayakumar

    2012-01-01

    Full Text Available The C=C bond in the title compound, C15H15NO4S, has a Z configuration. The thiazolidine ring is essentially planar [maximum deviation = 0.008 (1 Å for the N atom] and is oriented at a dihedral angle of 59.1 (1° with respect to the benzene ring. In the crystal, pairs of C—H...O hydrogen bonds link centrosymmetrically related molecules into dimers, generating R22(18 ring motifs. The crystal packing is further stabilized by C—H...π and C—O...π [O...centroid = 3.412 (2 Å and C—O...centroid = 115.0 (1°] interactions.

  20. SU-E-J-224: Multimodality Segmentation of Head and Neck Tumors

    Aristophanous, M; Yang, J; Beadle, B [UT MD Anderson Cancer Center, Houston, TX (United States)

    2014-06-01

    Purpose: Develop an algorithm that is able to automatically segment tumor volume in Head and Neck cancer by integrating information from CT, PET and MR imaging simultaneously. Methods: Twenty three patients that were recruited under an adaptive radiotherapy protocol had MR, CT and PET/CT scans within 2 months prior to start of radiotherapy. The patients had unresectable disease and were treated either with chemoradiotherapy or radiation therapy alone. Using the Velocity software, the PET/CT and MR (T1 weighted+contrast) scans were registered to the planning CT using deformable and rigid registration respectively. The PET and MR images were then resampled according to the registration to match the planning CT. The resampled images, together with the planning CT, were fed into a multi-channel segmentation algorithm, which is based on Gaussian mixture models and solved with the expectation-maximization algorithm and Markov random fields. A rectangular region of interest (ROI) was manually placed to identify the tumor area and facilitate the segmentation process. The auto-segmented tumor contours were compared with the gross tumor volume (GTV) manually defined by the physician. The volume difference and Dice similarity coefficient (DSC) between the manual and autosegmented GTV contours were calculated as the quantitative evaluation metrics. Results: The multimodality segmentation algorithm was applied to all 23 patients. The volumes of the auto-segmented GTV ranged from 18.4cc to 32.8cc. The average (range) volume difference between the manual and auto-segmented GTV was −42% (−32.8%–63.8%). The average DSC value was 0.62, ranging from 0.39 to 0.78. Conclusion: An algorithm for the automated definition of tumor volume using multiple imaging modalities simultaneously was successfully developed and implemented for Head and Neck cancer. This development along with more accurate registration algorithms can aid physicians in the efforts to interpret the multitude of imaging information available in radiotherapy today. This project was supported by a grant by Varian Medical Systems.

  1. 25 CFR 224.30 - What definitions apply to this part?

    2010-04-01

    ... Self-Determination Act of 2005, as promulgated in Title V of the Energy Policy Act of 2005, Public Law... Resources means both renewable and nonrenewable energy sources, including, but not limited to, natural gas....30 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL...

  2. 25 CFR 224.184 - How do other administrative appeals processes apply?

    2010-04-01

    ... administrative appeals process in 25 CFR part 2 and 43 CFR part 4 are modified, only as they apply to appeals under this part, as set forth in this section. (a) The definition of interested party in 25 CFR part 2 and as incorporated in 43 CFR part 4 does not apply to this part. (b) The right of persons or...

  3. (Z-2-[(2,4-Dimethylphenylimino]-1,3-thiazinan-4-one

    Xiang-Wu Meng

    2011-01-01

    Full Text Available In the title compound, C12H14N2OS, the 1,3-thiazinane ring displays a screw-boat conformation. In the crystal, pairs of centrosymmetrically related molecules are linked by pairs of N—H...O hydrogen bonds into dimers. C—H...π interactions occur between adjacent dimers.

  4. 50 CFR 224.101 - Enumeration of endangered marine and anadromous species.

    2010-10-01

    ... leucas), Cook Inlet distinct population segment; Blue whale (Balaenoptera musculus); Bowhead whale... whale (Balaenoptera physalus); Hawaiian monk seal (Monachus schauinslandi); Humpback whale (Megaptera... whale (Eubalaena australis); Saimaa seal (Phoca hispida saimensis); Sei whale (Balaenoptera...

  5. Radiochemical determination and separation or total radium, 226Ra and 224Ra

    Radiochemical purification and separation of radium has been carried out and the determination of total radium solubilized in aqueous samples has been studied assuming that all the alpha emitters of the sample have their origin in the 226Ra and elements of its desintegration chain. Also, the activities of 22Ra and 226 Ra have been evaluated separately doing a measurement after the chemical separation of the radium and another one 10 days after. (Author) 9 refs

  6. 2,2'-[(4-Methyl-2-phenylimidazolidine-1,3-diyl)bis(methylene)]diphenol

    Rivera, A.; Cardenas, L.; Ríos-Motta, J.; Eigner, Václav; Dušek, Michal

    2013-01-01

    Roč. 69, č. 8 (2013), o1198. ISSN 1600-5368 Grant ostatní: AVČR(CZ) Praemium Academiae Institutional research plan: CEZ:AV0Z10100521 Keywords : single-crystal X-ray study * Jana2006 * hydrogen bonds Subject RIV: CC - Organic Chemistry Impact factor: 0.347, year: 2011

  7. 2-[2-(4-Nitrophenylhydrazinylidene]-1,3-diphenylpropane-1,3-dione

    Carlos Bustos

    2011-07-01

    Full Text Available In the molecular structure of the title compound, C21H15N3O4, the interplanar angle between the benzoyl units is 89.7 (1°. The corresponding angles between the phenylhydrazono and the benzoyl groups are 31.4 (3 and 60.8 (2°, respectively. In the crystal, a strong resonance-assisted intramolecular hydrogen bond (N—H...O and a weak intramolecular hydrogen bond (C—H...N strongly affect the observed conformation of the molecule. The crystal packing is determined by a strong intermolecular hydrogen bond (N—H...O, giving rise to a helical chain along the a axis. In addition, two weak intermolecular contacts (C—H...O are observed.

  8. 2-[2-(4-Acetylphenylhydrazinylidene]-1,3-diphenylpropane-1,3-dione

    Carlos Bustos

    2011-08-01

    Full Text Available In the title compound, C23H18N2O3, the interplanar angle between the benzoyl units is 80.51 (6° while the dihedral angles between the hydrazinylidene and benzoyl groups are 43.43 (6 and 54.16 (6°. In the crystal, a strong resonance-assisted intramolecular N—H...O hydrogen bond is observed. The molecules form an inversion dimer via a pair of weak C—H...O hydrogen bonds and a π–π interaction [centroid–centroid distance of 3.5719 (10 Å]. These dimers are linked via weak C—H...O contacts, forming chains along the b axis.

  9. 49 CFR 173.224 - Packaging and control and emergency temperatures for self-reactive materials.

    2010-10-01

    ...-methoxyvaleronitrile) 3236 100 OP7 −5 +5 2,2′-Azodi(2,4-dimethylvaleronitrile) 3236 100 OP7 +10 +15 2,2′-Azodi(ethyl 2... sulphohydrazide 3226 100 OP7 4-(Benzyl(ethyl)amino)-3-ethoxybenzenediazonium zinc chloride 3226 100 OP7 4-(Benzyl... Tetramine palladium (II) nitrate 3234 100 OP6 +30 +35 Notes: 1. The emergency and control temperatures...

  10. Practical Pseudo-collisions for Hash Functions ARIRANG-224/384

    Guo, Jian; Matusiewicz, Krystian; Knudsen, Lars Ramkilde;

    2009-01-01

    In this paper we analyse the security of the SHA-3 candidate ARIRANG. We show that bitwise complementation of whole registers turns out to be very useful for constructing high-probability differential characteristics in the function. We use this approach to find near-collisions with Hamming weigh...

  11. SU-E-J-224: Multimodality Segmentation of Head and Neck Tumors

    Purpose: Develop an algorithm that is able to automatically segment tumor volume in Head and Neck cancer by integrating information from CT, PET and MR imaging simultaneously. Methods: Twenty three patients that were recruited under an adaptive radiotherapy protocol had MR, CT and PET/CT scans within 2 months prior to start of radiotherapy. The patients had unresectable disease and were treated either with chemoradiotherapy or radiation therapy alone. Using the Velocity software, the PET/CT and MR (T1 weighted+contrast) scans were registered to the planning CT using deformable and rigid registration respectively. The PET and MR images were then resampled according to the registration to match the planning CT. The resampled images, together with the planning CT, were fed into a multi-channel segmentation algorithm, which is based on Gaussian mixture models and solved with the expectation-maximization algorithm and Markov random fields. A rectangular region of interest (ROI) was manually placed to identify the tumor area and facilitate the segmentation process. The auto-segmented tumor contours were compared with the gross tumor volume (GTV) manually defined by the physician. The volume difference and Dice similarity coefficient (DSC) between the manual and autosegmented GTV contours were calculated as the quantitative evaluation metrics. Results: The multimodality segmentation algorithm was applied to all 23 patients. The volumes of the auto-segmented GTV ranged from 18.4cc to 32.8cc. The average (range) volume difference between the manual and auto-segmented GTV was −42% (−32.8%–63.8%). The average DSC value was 0.62, ranging from 0.39 to 0.78. Conclusion: An algorithm for the automated definition of tumor volume using multiple imaging modalities simultaneously was successfully developed and implemented for Head and Neck cancer. This development along with more accurate registration algorithms can aid physicians in the efforts to interpret the multitude of imaging information available in radiotherapy today. This project was supported by a grant by Varian Medical Systems

  12. A long-term study on the therapeutic effects of radium-224 in Bechterew's disease

    The article deals with the question of the real extents of the positive effects of Thorium x in Bechterew's disease and the risks which are taken by applying this treatment. 129 out of 200 patients treated in the Frankfurt clinic in the time 1952-1970 were explored with the help of a detailed list of questions. 80 of these patients could make a direct comparison with other treatment methods and stated the Thorium X-treatment to be substantially more efficient. A long-lasting improvement was seen in 52% of the patients. Out of 80 patients who underwent a post-examination, 79.5% felt an improvement directly after the treatment, 75.6% even still 2 years after the treatment. The clinical values and the laboratory examinations, however, did not reveal such a favourable picture. In a comparison group of patients who had not been treated with Thorium X, only 19.9% showed an improvement. Using the usual methods of clinic, lab., and radiology, no radiation damage could be observed. The author is of the opinion that treatment with Thorium X does not bear an increased risk, if compared with medicamentous treatment methods. However, strict indication and exact dosage should be adhered to. (MG)

  13. Late radiation effects following thorium X treatment (224Ra) of Bechterew's disease

    181 patients with ankylosing spondylitis (Bechterew's disease), who had been treated with thorium X 5 to 15 years ago, were examined by laboratory tests and a questionnaire. By means of the questionnaire secondary diseases such as blood and tumor diseases were to be identified and died patients ascertained. The evaluation of the laboratory findings, especially the activity of the leukocytic alkaline phosphatase, was used to screen for neoplasias or preleukemic states. According to the literature we could show that the 'Troch-era' (1946-51) resulted in somatic radiation damages after thorium X application. During this era high doses of 'Peteosthor' contaminated with long-lived nuclides were used for therapy of extrapulmonary tuberculosis especially in children. The thorium X therapy used today is safe and radiation damages are not to be expected. (author)

  14. Linear systems analysis program, L224(QR). Volume 2: Supplemental system design and maintenance document

    Heidergott, K. W.

    1979-01-01

    The computer program known as QR is described. Classical control systems analysis and synthesis (root locus, time response, and frequency response) can be performed using this program. Programming details of the QR program are presented.

  15. Practical Pseudo-collisions for Hash Functions ARIRANG-224/384

    Guo, Jian; Matusiewicz, Krystian; Knudsen, Lars Ramkilde; Ling, San; Wang, Huaxiong

    In this paper we analyse the security of the SHA-3 candidate ARIRANG. We show that bitwise complementation of whole registers turns out to be very useful for constructing high-probability differential characteristics in the function. We use this approach to find near-collisions with Hamming weigh...

  16. People and things. CERN Courier, May 1982, v. 22(4)

    The article reports on achievements of various people, staff changes and position opportunities within the CERN organization and contains news updates on upcoming or past events. The 1982 Summer Workshop on Proton Decay Experiments will be held from 7-11 June at Argonne National Laboratory. Its purpose is to bring together experimenters and theorists with an active interest in the next generation of proton decay experiments. A workshop will be held at Los Alamos from 19-22 July to discuss the LAMPF II project for a rapid cycling 16 GeV synchrotron providing 1013 protons per pulse. 'The challenge of attaining ultra high energies' - This is the title of a meeting to review limitations and possibilities in particle acceleration to ultra high energies, organized jointly by ECFA and the Rutherford Laboratory. The topics for discussion will include the use of high electric fields generated in plasmas, external fields in short wave r.f. linacs, and laser illuminated gratings

  17. Study on laser atomic spectroscopy

    Laser atomic spectroscopic study on actinium element has been performed in many areas of spectroscopy. The study on characteristic of atomic vapor has been proceeded for copper atom and the spatial density distribution of copper vapor is measured. This experimental data has been compared with the theoretically calculated data. In spectroscopic experiment, the first and second excited states for actinium element are identified and the most efficient ionization scheme for actinium element is identified. In addition, the corrosion problem for filament material due to the heating of the actinium element has been studied. (Author)

  18. A Critical Review of Alpha Radionuclide Therapy-How to Deal with Recoiling Daughters?

    de Kruijff, Robin M; Wolterbeek, Hubert T; Denkova, Antonia G

    2015-01-01

    This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET). Touching briefly on the clinical successes of radionuclides emitting only one alpha particle, the main focus of this article lies on those alpha-emitting radionuclides with multiple alpha-emitting daughters in their decay chain. While having the advantage of longer half-lives, the recoiled daughters of radionuclides like 224Ra (radium), 223Ra, and 225Ac (actinium) can do significant damage to healthy tissue when not retained at the tumour site. Three different approaches to deal with this problem are discussed: encapsulation in a nano-carrier, fast uptake of the alpha emitting radionuclides in tumour cells, and local administration. Each approach has been shown to have its advantages and disadvantages, but when larger activities need to be used clinically, nano-carriers appear to be the most promising solution for reducing toxic effects, provided there is no accumulation in healthy tissue. PMID:26066613

  19. A Critical Review of Alpha Radionuclide Therapy—How to Deal with Recoiling Daughters?

    de Kruijff, Robin M.; Wolterbeek, Hubert T.; Denkova, Antonia G.

    2015-01-01

    This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET). Touching briefly on the clinical successes of radionuclides emitting only one alpha particle, the main focus of this article lies on those alpha-emitting radionuclides with multiple alpha-emitting daughters in their decay chain. While having the advantage of longer half-lives, the recoiled daughters of radionuclides like 224Ra (radium), 223Ra, and 225Ac (actinium) can do significant damage to healthy tissue when not retained at the tumour site. Three different approaches to deal with this problem are discussed: encapsulation in a nano-carrier, fast uptake of the alpha emitting radionuclides in tumour cells, and local administration. Each approach has been shown to have its advantages and disadvantages, but when larger activities need to be used clinically, nano-carriers appear to be the most promising solution for reducing toxic effects, provided there is no accumulation in healthy tissue. PMID:26066613

  20. A Critical Review of Alpha Radionuclide Therapy—How to Deal with Recoiling Daughters?

    Robin M. de Kruijff

    2015-06-01

    Full Text Available This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET. Touching briefly on the clinical successes of radionuclides emitting only one alpha particle, the main focus of this article lies on those alpha-emitting radionuclides with multiple alpha-emitting daughters in their decay chain. While having the advantage of longer half-lives, the recoiled daughters of radionuclides like 224Ra (radium, 223Ra, and 225Ac (actinium can do significant damage to healthy tissue when not retained at the tumour site. Three different approaches to deal with this problem are discussed: encapsulation in a nano-carrier, fast uptake of the alpha emitting radionuclides in tumour cells, and local administration. Each approach has been shown to have its advantages and disadvantages, but when larger activities need to be used clinically, nano-carriers appear to be the most promising solution for reducing toxic effects, provided there is no accumulation in healthy tissue.

  1. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin

    The objective of this work was to establish a new procedure for 228Ra determination of natural waters via preconcentration of radium on MnO2 and separation of its daughter, 228Ac, using Diphonix ion exchange resin. Following removal of potential interferences via passage through an initial Diphonix Resin column, the first daughter of 228Ra, 228Ac, is isolated by chromatographic separation via a second Diphonix column. A holding time of >30 h for 228Ac ingrowth in between the two column separations ensures secular equilibrium. Barium-133 is used as a yield tracer. Actinium-228 is eluted from the second Diphonix Resin with 5 ml 1 M 1-Hydroxyethane-1,1-diphosphonic acid (HEDPA) and quantified by addition of scintillation cocktail and LSC counting. Radium (and 133Ba) from the load and rinse solutions from the 2nd Diphonix column may be prepared for alpha spectrometry (for determination of 223Ra, 224Ra, and 226Ra) by BaSO4 microprecipitation and filtration. Decontamination tests indicate that U, Th, and Ra series nuclides do not interfere with these measurements, although high contents of 90Sr (90Y) require additional treatment for accurate measurement of 228Ra. Addition of stable Sr as a 'hold back' carrier during the initial MnO2 preconcentration step was shown to remove most 90Sr interference

  2. Removal of actinium from europium for the determination of specific radioactivity of ultra low-level Eu-152 in a sample exposed to atomic-bomb neutrons in Nagasaki

    Measurements of specific radioactivities of residual neutron-induced radionuclides such as 152Eu and 60Co have been carried out to check the validity of a series of computer calculations employed for the atomic-bomb neutron dosimetry in Hiroshima (exposed to uranium bomb) and Nagasaki (exposed to plutonium bomb). The use of these nuclides for atomic-bomb neutron dosimetry, however, has been limited by the following difficulties: (1) today, these radionuclides are found only at extremely low concentrations in materials exposed to the atomic-bomb and (2) the neutrons that induced these radionuclides were thermal and epithermal, while the neutron dose received in Hiroshima and Nagasaki is attributable to fast neutrons. In order to overcome the first difficulty, we established a chemical procedure to extract Eu and Co from materials exposed to the atomic-bomb, and the chemical procedure has been successful for the materials exposed to atomic-bomb within 1400 m in slant distance from the explosion point. As for Nagasaki, materials exposed in the distances farther than 1200 m have never been subjected to the measurement of residual neutron-induced radionuclides. In this work, determination of specific radioactivity of 152Eu (half-life: 13.542 y) in a sample exposed to Nagasaki atomic-bomb at a distant place from the explosion point was undertaken. But, because of radioactive decay during this ∝60 years since 1945 and long distance from the explosion point, the present specific radioactivity of 152Eu in the sample is extremely low (estimated to be ∝3 x 10-4 Bq-152Eu/mg-Eu), and a serious problem is interferences from daughters of 227Ac (half-life: 21.8 y) in the measurement of ultra low-level radioactivity of 152Eu. Hence, our chemical procedure to obtain Eu-enriched counting source should be improved, and much attention is being denoted to removal of Ac from Eu. (orig.)

  3. 2,2-Diethyl 4-methyl 5-(4-nitrophenyl-4-phenylpyrrolidine-2,2,4-tricarboxylate

    Long He

    2011-10-01

    Full Text Available The title compound, C24H26N2O8, was synthesized by the cycloaddition reaction of methyl 2-phenylacrylate, diethyl 2-aminomalonate and 4-nitrobenzaldehyde. The pyrrolidine ring exhibits an envelope conformation. The two benzene rings are located on opposite sides of the pyrrolidine ring and subtend a dihedral angle of 59.16 (14°. The crystal packing is stabilized by N—H...O and weak C—H...O hydrogen bonding.

  4. 40 CFR 22.4 - Powers and duties of the Environmental Appeals Board, Regional Judicial Officer and Presiding...

    2010-07-01

    ... RULES OF PRACTICE GOVERNING THE ADMINISTRATIVE ASSESSMENT OF CIVIL PENALTIES AND THE REVOCATION... any functions of prosecution or investigation within the 2 years preceding the commencement of the... any person who supervises the prosecution of enforcement cases, but may be supervised by the...

  5. Radon fixation for determination of {sup 224}Ra, {sup 226}Ra and {sup 228}Ra via gamma-ray spectrometry

    Herranz, M. [Departamento Ingenieria Nuclear y Mecanica de Fluidos, E. S. Ingenieros de Bilbao - Universidad del Pais Vasco (UPV/EHU), Alda. Urquijo s/n, 48013 Bilbao (Spain)]. E-mail: inphesom@bi.ehu.es; Idoeta, R. [Departamento Ingenieria Nuclear y Mecanica de Fluidos, E. S. Ingenieros de Bilbao - Universidad del Pais Vasco (UPV/EHU), Alda. Urquijo s/n, 48013 Bilbao (Spain); Abelairas, A. [Departamento Ingenieria Nuclear y Mecanica de Fluidos, E. S. Ingenieros de Bilbao - Universidad del Pais Vasco (UPV/EHU), Alda. Urquijo s/n, 48013 Bilbao (Spain); Legarda, F. [Departamento Ingenieria Nuclear y Mecanica de Fluidos, E. S. Ingenieros de Bilbao - Universidad del Pais Vasco (UPV/EHU), Alda. Urquijo s/n, 48013 Bilbao (Spain)

    2006-04-15

    The aim of this work is the improvement of the procedure for the determination of radium isotopes activities in water, which is done through radiochemical separation and subsequent gamma-ray spectrometry. In addition, radon gas retention is studied using different activated carbon materials. The results of the IAEA Proficiency test: 'Determination of radium and uranium radionuclides in water' of December 2002 [IAEA, 2003. Analytical quality control services: determination of radium and uranium radionuclides in water. Preliminary Report, Seibersdorf] are considered for this work.

  6. 2-(2,4-Difluorophenyl-4,5-dimethyl-1-(4-methylphenyl-1H-imidazole monohydrate

    Natesan Srinivasan

    2013-11-01

    Full Text Available The asymmetric unit of the title compound, C18H16F2N2·H2O, contains two independent molecules (A and B, and two independent water molecules of crystallization. In molecule A, the imidazole ring makes dihedral angles of 47.46 (7 and 60.98 (6° with the 2,4-difluorophenyl and methylphenyl rings, respectively. The corresponding angles in molecule B are 45.85 (7 and 62.78 (7°, respectively. The dihedral angle between the two benzene rings is 64.98 (7° in molecule A and 65.53 (7° in molecule B. In the crystal, the two independent molecules are linked by O—H...N and O—H...O hydrogen bonds, forming chains propagating along [100]. These chains are linked via C—H...F hydrogen bonds, forming slab-like two-dimensional networks lying parallel to (001.

  7. Rob Hopkins, 2008, The Transition Handbook. From Oil Dependency to Local Resilience, Green books, 224 p.

    Luc Semal

    2008-07-01

    Full Text Available Le mouvement pour la Transition (ou Transition movement a été initié en 2005 à Totnes (Devon par Rob Hopkins, professeur de permaculture qui avait été sensibilisé au thème du pic du pétrole quelques mois auparavant : à l’époque, il s’agissait seulement d’élaborer une stratégie locale pour que Totnes puisse à l’avenir se passer de pétrole sans en souffrir. Mais d’autres groupes locaux ont rapidement suivi cet exemple, et en mai 2008, le « réseau de la Transition » comptait déjà 50 localités ...

  8. SU-E-T-224: Is Monte Carlo Dose Calculation Method Necessary for Cyberknife Brain Treatment Planning?

    Wang, L; Fourkal, E; Hayes, S; Jin, L; Ma, C [Fox Chase Cancer Center, Philadelphia, PA (United States)

    2014-06-01

    Purpose: To study the dosimetric difference resulted in using the pencil beam algorithm instead of Monte Carlo (MC) methods for tumors adjacent to the skull. Methods: We retrospectively calculated the dosimetric differences between RT and MC algorithms for brain tumors treated with CyberKnife located adjacent to the skull for 18 patients (total of 27 tumors). The median tumor sizes was 0.53-cc (range 0.018-cc to 26.2-cc). The absolute mean distance from the tumor to the skull was 2.11 mm (range - 17.0 mm to 9.2 mm). The dosimetric variables examined include the mean, maximum, and minimum doses to the target, the target coverage (TC) and conformality index. The MC calculation used the same MUs as the RT dose calculation without further normalization and 1% statistical uncertainty. The differences were analyzed by tumor size and distance from the skull. Results: The TC was generally reduced with the MC calculation (24 out of 27 cases). The average difference in TC between RT and MC was 3.3% (range 0.0% to 23.5%). When the TC was deemed unacceptable, the plans were re-normalized in order to increase the TC to 99%. This resulted in a 6.9% maximum change in the prescription isodose line. The maximum changes in the mean, maximum, and minimum doses were 5.4 %, 7.7%, and 8.4%, respectively, before re-normalization. When the TC was analyzed with regards to target size, it was found that the worst coverage occurred with the smaller targets (0.018-cc). When the TC was analyzed with regards to the distance to the skull, there was no correlation between proximity to the skull and TC between the RT and MC plans. Conclusions: For smaller targets (< 4.0-cc), MC should be used to re-evaluate the dose coverage after RT is used for the initial dose calculation in order to ensure target coverage.

  9. Astronomical studies of the major planets, natural satellites and asteroids using the 2.24 m telescope

    Jefferies, J. T.

    1982-01-01

    Ground based detection of east-west asymmetries in the Jovian torus, three dimensional models of the plasma conditions in the Jovian torus, rotational variations in methane band images of Neptune, Io's rapid flickering, thermophysical models, the diameters and albedos of the satellites of Uranus from radiometric observations, the diameters of Pluto and Triton, standard stars are discussed.

  10. 2-(2,4-Dichlorophenyl-9-phenyl-2,3-dihydrothieno[3,2-b]quinoline

    K. Balamurugan

    2009-08-01

    Full Text Available In the title compound, C23H15Cl2NS, the quinoline system is almost planar [r.m.s. deviation = 0.013 (2 Å]. The phenyl group is disordered over two positions with site occupancies of 0.55 and 0.45, and is oriented in a nearly perpendicular configuration to the quinoline ring [the dihedral angles between the quinoline ring and the major and minor disordered components of the phenyl ring are 81.8 (2 and 71.6 (2°, respectively]. The dihydrothiene ring adopts an envelope conformation. The dihedral angle between the chlorophenyl ring and the quinoline system is 79.32 (1°. In the crystal weak C—H...π interactions occur.

  11. 2-(2,4-Dichlorophenyl)-9-phenyl-2,3-dihydrothieno[3,2-b]quinoline

    K. Balamurugan; D. Narmadha; Suresh, J.; Perumal, S.; P. L. Nilantha Lakshman

    2009-01-01

    In the title compound, C23H15Cl2NS, the quinoline system is almost planar [r.m.s. deviation = 0.013 (2) Å]. The phenyl group is disordered over two positions with site occupancies of 0.55 and 0.45, and is oriented in a nearly perpendicular configuration to the quinoline ring [the dihedral angles between the quinoline ring and the major and minor disordered components of the phenyl ring are 81.8 (2) and 71.6 (2)°, respectively]. The dih...

  12. 75 FR 41337 - Implementation of Section 224 of the Act; A National Broadband Plan for Our Future

    2010-07-15

    ... Rulemaking Proceedings, 63 FR 24121 (1998). Electronic Filers: Comments may be filed electronically using the... clock. Are guidelines necessary or helpful? What type of communication or notice between parties is... separate entities, be aggregated into a national database? 39. To gain perspective on the scope of...

  13. A second monoclinic polymorph of 2-[2-(4-methoxyphenylhydrazinylidene]-1,3-diphenylpropane-1,3-dione

    Carlos Bustos

    2011-07-01

    Full Text Available The title compound, C22H18N2O3 is the second monoclinic polymorph (P21/c of the compound, the first being reported in space group P21 [Bertolasi et al. (1993. J. Chem. Soc. Perkin Trans. 2, pp. 2223–2228]. In the molecular structure of the title compound, the interplanar angle between the benzoyl units is 80.04 (5°, while the corresponding angles between the phenylhydrazinylidene and benzoyl groups are 36.11 (5 and 55.77 (2°. A strong resonance-assisted intramolecular N—H...O hydrogen bond is found. In the crystal, the entire supramolecular structure is constructed by weak intermolecular C—H...O interactions and an inter-ring π–π interaction [centroid–centroid distance = 3.6088 (8 Å].

  14. American Recovery and Reinvestment Act (ARRA) Federal Energy Management Program Technical Assistance Project 224 Altus Air Force Base Solar Technologies

    Russo, Bryan J.

    2010-09-30

    The principal goal of this project was to evaluate altus Air Force Base for building integrated silicon or thin film module photovoltaic opportunities. This report documents PNNL's efforts and documents study conclusions.

  15. Radon fixation for determination of 224Ra, 226Ra and 228Ra via gamma-ray spectrometry

    The aim of this work is the improvement of the procedure for the determination of radium isotopes activities in water, which is done through radiochemical separation and subsequent gamma-ray spectrometry. In addition, radon gas retention is studied using different activated carbon materials. The results of the IAEA Proficiency test: 'Determination of radium and uranium radionuclides in water' of December 2002 [IAEA, 2003. Analytical quality control services: determination of radium and uranium radionuclides in water. Preliminary Report, Seibersdorf] are considered for this work

  16. Bis{2-[(2,4-dimethylphenyliminomethyl]pyridine-κ2N,N′}bis(thiocyanato-κNcadmium

    Mohammad Malekshahian

    2012-02-01

    Full Text Available The title compound, [Cd(NCS2(C14H14N22], features crystallographic inversion symmetry with the CdII ion located on a centre of inversion. The CdII ion is six-coordinated in a slightly distorted octahedral geometry with the thiocyanate anions in axial positions. The angle between the benzene and pyridine rings is 69.64 (9°. An intermolecular C—H...S hydrogen bond stabilizes the crystal structure.

  17. Generator method of 225Ac production without a carrier for nuclear medicine

    The two-steps isotope generator scheme of 225Ac production from 229Th has been developed. The first step is used for separation of thorium, actinium, radium and daughter decay products (DDP), and removals of parent radionuclide. The second step provides additional separation of actinium from traces of radium and DDP, and conversion of actinium in the nitrate form. The chosen solutions provide optimal conditions for carry out of process. The yield of the 225Ac was 99.9% at minimal losses of parent 229Th (less than 0.1%)

  18. Alpha-emitting isotopes and chromium in a coastal California aquifer

    Densmore, Jill N.; Izbicki, John A.; Murtaugh, Joseph M.; Swarzenski, Peter W.; Bullen, Thomas D.

    2014-01-01

    The unadjusted 72-h gross alpha activities in water from two wells completed in marine and alluvial deposits in a coastal southern California aquifer 40 km north of San Diego were 15 and 25 picoCuries per liter (pCi/L). Although activities were below the Maximum Contaminant Level (MCL) of 15 pCi/L, when adjusted for uranium activity; there is concern that new wells in the area may exceed MCLs, or that future regulations may limit water use from the wells. Coupled well-bore flow and depth-dependent water-quality data collected from the wells in 2011 (with analyses for isotopes within the uranium, actinium, and thorium decay-chains) show gross alpha activity in marine deposits is associated with decay of naturally-occurring 238U and its daughter 234U. Radon activities in marine deposits were as high as 2230 pCi/L. In contrast, gross alpha activities in overlying alluvium within the Piedra de Lumbre watershed, eroded from the nearby San Onofre Hills, were associated with decay of 232Th, including its daughter 224Ra. Radon activities in alluvium from Piedra de Lumbre of 450 pCi/L were lower than in marine deposits. Chromium VI concentrations in marine deposits were less than the California MCL of 10 μg/L (effective July 1, 2014) but δ53Cr compositions were near zero and within reported ranges for anthropogenic chromium. Alluvial deposits from the nearby Las Flores watershed, which drains a larger area having diverse geology, has low alpha activities and chromium as a result of geologic and geochemical conditions and may be more promising for future water-supply development.

  19. SU-E-J-224: Using UTE and T1 Weighted Spin Echo Pulse Sequences for MR-Only Treatment Planning; Phantom Study

    Yu, H; Fatemi, A [Sunnybrook Health Sciences Centre, Toronto, Ontario (Canada); Sahgal, A [University of Toronto, Toronto, ON (Canada)

    2015-06-15

    Purpose: Investigating a new approach in MRI based treatment planning using the combination of (Ultrashort Echo Time) UTE and T1 weighted spin echo pulse sequences to delineate air, bone and water (soft tissues) in generating pseudo CT images comparable with CT. Methods: A gel phantom containing chicken bones, ping pang balls filled with distilled water and air bubbles, was made. It scanned with MRI using UTE and 2D T1W SE pulse sequences with (in plane resolution= 0.53mm, slice thickness= 2 mm) and CT with (in plane resolution= 0.5 mm and slice thickness= 0.75mm) as a ground truth for geometrical accuracy. The UTE and T1W SE images were registered with CT using mutual information registration algorithm provided by Philips Pinnacle treatment planning system. The phantom boundaries were detected using Canny edge detection algorithm for CT, and MR images. The bone, air bubbles and water in ping pong balls were segmented from CT images using threshold 300HU, - 950HU and 0HU, respectively. These tissue inserts were automatically segmented from combined UTE and T1W SE images using edge detection and relative intensity histograms of the phantom. The obtained segmentations of air, bone and water inserts were evaluated with those obtained from CT. Results: Bone and air can be clearly differentiated in UTE images comparable to CT. Combining UTE and T1W SE images successfully segmented the air, bone and water. The maximum segmentation differences from combine MRI images (UTE and T1W SE) and CT are within 1.3 mm, 1.1mm for bone, air, respectively. The geometric distortion of UTE sequence is small less than 1 pixel (0.53 mm) of MR image resolution. Conclusion: Our approach indicates that MRI can be used solely for treatment planning and its quality is comparable with CT.

  20. Analysis of back-propagation and RF pilot-tone based nonlinearity compensation for a 9x224Gb/s POLMUX-16QAM system

    Díaz Souto, Alberto; Napoli, Antonio; Adhikari, Susmita; Maalej, Zied; Lobato Polo, Adriana P.; Kuschnerov, Maxim; Prat Gomà, Josep Joan

    2012-01-01

    We investigate the joint implementation of back-propagation and RF-pilot tone for fiber nonlinear compensation in POLMUX-16QAM and show that the nonlinear tolerance is drastically improved when compared to OFDM system Peer Reviewed

  1. On the Question of an Ultraviolet Zero of the Beta Function of the $\\lambda (\\vec{\\phi}^2)^2_4$ Theory

    Shrock, Robert

    2014-01-01

    We investigate the possibility of an ultraviolet (UV) zero in the $n$-loop beta function of a $\\lambda (\\vec{\\phi}^2)^2$ field theory with an $N$-component scalar field, $\\vec{\\phi}$, in four spacetime dimensions, up to the level of $n=5$ loops. Although the two-loop beta function has a UV zero, we find that the $n$-loop beta function for $n=3, \\ 4, \\ 5$ either does not have a UV zero or does not have one at a value of $\\lambda$ in approximate agreement with the two-loop calculation. Similar results are obtained after application of scheme transformations to the beta function and via calculation of Pad\\'e approximants. We thus conclude that in the range of $\\lambda$ where the perturbative calculation of the $n$-loop beta function is reliable, the theory does not exhibit robust evidence of a UV zero up to the level of $n=5$ loops.

  2. Crystal structure of 2,2,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine hemihydrate

    K. S. Ezhilarasi

    2015-08-01

    Full Text Available The title compound, C12H18N2·0.5H2O, crystallizes with two independent organic molecules (A and B in the asymmetric unit, together with a water molecule of crystallization. The diazepine rings in each molecule have a chair conformation. The dihedral angle between benzene ring and the mean plane of the diazepine ring is 21.15 (12° in molecule A and 17.42 (11° in molecule B. In the crystal, molecules are linked by N—H...O and O—H...N hydrogen bonds, forming zigzag chains propagating along [001].

  3. Acetalization of carbonyl compounds with 2,2,4-trimethyl-1,3-pentanedio catalyzed by novel carbon based solid acid catalyst

    Ling Liu; Yuechang Zhao; Shan Gan; Xuezheng Liang; Jianguo Yang; Mingyuan He

    2008-01-01

    The synthesis of 2, 4-diisopropyl-5,5-dimethyl-1,3-dioxane through the acetalization of isobutyraldehyde with 2, 2,4-trimethyl-1,3-pentanediol (TMPD) catalyzed by the novel carbon based acid was first carried out. High conversion (≥98%) and specific selectivity were obtained using the novel carbon based acid, which kept high activity after it was reused 5 times.Moreover, the catalyst could be used to catalyze the acetalization and ketalization of different aldehydes and ketones with superior yield. The yield of several products was over 90%. The novel heterogeneous catalyst has the distinct advantages of high activity, strikingly simple workup procedure, non-pollution, and reusability, which will contribute to the success of the green process greatly.

  4. Synthesis, spectroscopic studies and crystal structure of ( E)-2-(2,4-dihydroxybenzylidene)thiosemicarbazone and ( E)-2-[(1 H-indol-3-yl)methylene]thiosemicarbazone

    Yıldız, Mustafa; Ünver, Hüseyin; Erdener, Diğdem; Kiraz, Aşkın; İskeleli, Nazan Ocak

    2009-02-01

    Thiosemicarbazone Schiff bases ( 1 and 2) derived from 2,4-dihydroxybenzaldehyde, indoline-3-carbaldehyde and thiosemicarbazone have been synthesized and their structures were elucidated by elemental analysis, FT-IR, 1H NMR, 13C NMR and UV-visible spectroscopic techniques. The structures of compounds 1 and 2 have also been examined cyrstallographically. The title compounds 1 and 2 crystallize in the monoclinic space group C2/ c and triclinic space group P1¯, with unit cell parameters: a = 21.421(1) and 7.233(1), b = 4.131(1) and 11.166(1), c = 24.942(2) and 13.648(1) Å, V = 1856.1(2) and 1019.5(1) Å 3, D x = 1.512 and 1.422 g cm -3 and Z = 8 and 4, respectively.

  5. Prevalence study: main illicit psychoactive susbtances among all drivers involved in fatal road crashes in France. Delivrable 2.2.4

    Amoros, E.; Gadegbeku, B.; THE SAM GROUP; 103-111,

    2010-01-01

    In 1999, in France, before considering change in the drug legislation, the government wished to know more on the effect of illicit drugs on the risk of road crashes. A systematic screening of illicit drug on all drivers involved in fatal crashes, was hence made compulsory. We estimate prevalences of alcohol, cannabis, amphetamines, cocaine, and opiates. We provide them for drivers of all vehicles types, as well as for car drivers only. We also provide estimates of prevalences in the general p...

  6. Isothermal (Vapour + Liquid) Equilibria in the Binary and Ternary Systems Composed of 2-Propanol, 2,2,4-Trimethylpentane and 2,4-Dimethyl-3-Pentanone

    Pavlíček, Jan; Wichterle, Ivan

    2012-01-01

    Roč. 45, č. 1 (2012), s. 83-89. ISSN 0021-9614 R&D Projects: GA ČR GA104/07/0444 Institutional research plan: CEZ:AV0Z40720504 Keywords : alcohol * ketone * hydrocarbon Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 2.297, year: 2012

  7. Detailed investigation of Na2.24FePO4CO3 as a cathode material for Na-ion batteries

    Weifeng Huang; Jing Zhou; Biao Li; Jin Ma; Shi Tao; Dingguo Xia; Wangsheng Chu; Ziyu Wu

    2014-01-01

    Na-ion batteries are gaining an increased recognition as the next generation low cost energy storage devices. Here, we present a characterization of Na3FePO4CO3 nanoplates as a novel cathode material for sodium ion batteries. First-principles calculations reveal that there are two paths for Na ion migration along b and c axis. In-situ and ex-situ Fe K-edge X-ray absorption near edge structure (XANES) point out that in Na3FePO4CO3 both Fe2+/Fe3+ and Fe3+/Fe4+ redox couples are electrochemicall...

  8. (2RS-2-(2,4-Difluorophenyl-1-[(4-iodobenzyl(methylamino]-3-(1H-1,2,4-triazol-1-ylpropan-2-ol

    Hui-Ping Xiong

    2012-08-01

    Full Text Available In the title compound (common name: iodiconazole, C19H19F2IN4O, there is an intramolecular O—H...N hydrogen bond and molecules are linked by weak interactions only, namely C—H...N, C—H...O and C—H...F hydrogen bonds, and π-electron ring–π-electron ring interactions between the triazole rings with centroid–centroid distances of 3.725 (3 Å.

  9. Commercial thinning of mature lodgepole pine to reduce susceptibility to mountain pine beetle. FRDA report No. 224, and FERIC special report No. SR-94

    Mitchell, J.L.

    1994-12-31

    This report presents results of a study conducted to examine the effect of commercial thinning and fertilizing of lodgepole pine on attack by mountain pine beetle (Dendroctonus ponderosa Hopk.). At three study sites in the Cranbrook and Invermere Forest Districts of British Columbia, the researchers compared three harvesting treatments to an uncut control: a clearcut and commercial thins leaving trees at about 4- or 5-meter spacings. Equipment used included conventional hand-falling plus line skidders and crawler tractors, or mechanical systems including a feller-buncher, grapple-skidder, and excavator-mounted processor. The report documents the productivity and costs of the commercial thinning and clearcut harvesting operations, and compares the productivity of the equipment and practices used during the harvesting phase on each treatment. It also examines the operational feasibility of commercial thinning.

  10. Synergistic Effect of S224P and N383D Substitutions in the PA of H5N1 Avian Influenza Virus Contributes to Mammalian Adaptation

    Jiasheng Song; Jing Xu; Jianzhong Shi; Yanbing Li; Hualan Chen

    2015-01-01

    The adaptation of H5N1 avian influenza viruses to human poses a great threat to public health. Previous studies indicate the adaptive mutations in viral polymerase of avian influenza viruses are major contributors in overcoming the host species barrier, with the majority of mammalian adaptive mutations occurring in the PB2 protein. However, the adaptive mutations in the PA protein of the H5N1 avian influenza virus are less defined and poorly understood. In this study, we identified the synerg...

  11. Localization and Characterization of Two Novel Genes Encoding Stereospecific Dioxygenases Catalyzing 2(2,4-Dichlorophenoxy)propionate Cleavage in Delftia acidovorans MC1

    Schleinitz, Kathleen M.; Kleinsteuber, Sabine; Vallaeys, Tatiana; Babel, Wolfgang

    2004-01-01

    Two novel genes, rdpA and sdpA, encoding the enantiospecific α-ketoglutarate dependent dioxygenases catalyzing R,S-dichlorprop cleavage in Delftia acidovorans MC1 were identified. Significant similarities to other known genes were not detected, but their deduced amino acid sequences were similar to those of other α-ketoglutarate dioxygenases. RdpA showed 35% identity with TauD of Pseudomonas aeruginosa, and SdpA showed 37% identity with TfdA of Ralstonia eutropha JMP134. The functionally impo...

  12. Localization and characterization of two novel genes encoding stereospecific dioxygenases catalyzing 2(2,4-dichlorophenoxy)propionate cleavage in Delftia acidovorans MC1.

    Schleinitz, Kathleen M; Kleinsteuber, Sabine; Vallaeys, Tatiana; Babel, Wolfgang

    2004-09-01

    Two novel genes, rdpA and sdpA, encoding the enantiospecific alpha-ketoglutarate dependent dioxygenases catalyzing R,S-dichlorprop cleavage in Delftia acidovorans MC1 were identified. Significant similarities to other known genes were not detected, but their deduced amino acid sequences were similar to those of other alpha-ketoglutarate dioxygenases. RdpA showed 35% identity with TauD of Pseudomonas aeruginosa, and SdpA showed 37% identity with TfdA of Ralstonia eutropha JMP134. The functionally important amino acid sequence motif HX(D/E)X(23-26)(T/S)X(114-183)HX(10-13)R/K, which is highly conserved in group II alpha-ketoglutarate-dependent dioxygenases, was present in both dichlorprop-cleaving enzymes. Transposon mutagenesis of rdpA inactivated R-dichlorprop cleavage, indicating that it was a single-copy gene. Both rdpA and sdpA were located on the plasmid pMC1 that also carries the lower pathway genes. Sequencing of a 25.8-kb fragment showed that the dioxygenase genes were separated by a 13.6-kb region mainly comprising a Tn501-like transposon. Furthermore, two copies of a sequence similar to IS91-like elements were identified. Hybridization studies comparing the wild-type plasmid and that of the mutant unable to cleave dichlorprop showed that rdpA and sdpA were deleted, whereas the lower pathway genes were unaffected, and that deletion may be caused by genetic rearrangements of the IS91-like elements. Two other dichlorprop-degrading bacterial strains, Rhodoferax sp. strain P230 and Sphingobium herbicidovorans MH, were shown to carry rdpA genes of high similarity to rdpA from strain MC1, but sdpA was not detected. This suggested that rdpA gene products are involved in the degradation of R-dichlorprop in these strains. PMID:15345421

  13. Bis{2-[(2,4-dimethyl-phen-yl)imino-meth-yl]pyridine-κN,N'}bis-(thio-cyanato-κN)cadmium.

    Malekshahian, Mohammad; Talei Bavil Olyai, Mohamad Reza; Notash, Behrouz

    2012-02-01

    The title compound, [Cd(NCS)(2)(C(14)H(14)N(2))(2)], features crystallographic inversion symmetry with the Cd(II) ion located on a centre of inversion. The Cd(II) ion is six-coordinated in a slightly distorted octa-hedral geometry with the thiocyanate anions in axial positions. The angle between the benzene and pyridine rings is 69.64 (9)°. An inter-molecular C-H⋯S hydrogen bond stabilizes the crystal structure. PMID:22346881

  14. Design, synthesis, biological activities, and 3D-QSAR of new N,N'-diacylhydrazines containing 2-(2,4-dichlorophenoxy)propane moiety.

    Liu, Xing-Hai; Pan, Li; Ma, Yi; Weng, Jian-Quan; Tan, Cheng-Xia; Li, Yong-Hong; Shi, Yan-Xia; Li, Bao-Ju; Li, Zheng-Ming; Zhang, Yong-Gang

    2011-10-01

    A series of new N,N'-diacylhydrazine derivatives were synthesized efficiently under microwave irradiation. Their structures were characterized by (1) H NMR, MS, and elemental analysis. Various biological activities of these compounds were tested. Most of them exhibited higher herbicidal activities against dicotyledonous weeds than monocotyledonous weeds. In addition, favorable in vivo fungicidal activities were also found of these compounds against Cladosporium cucumerinum, Corynespora cassiicola, Sclerotinia sclerotiorum(Lib.)de Bary, Erysiphe cichoracearum, and Colletotrichum orbiculare (Berk aLMont) Arx. All compounds displayed excellent plant growth regulatory activities: 100% inhibition was achieved against the radicle growth of cucumber. To further investigate the structure-activity relationship, comparative molecular field analysis was performed on the basis of herbicidal activity data, resulting in a statistically reliable model with good predictive power (r(2) = 0.913, q(2) =0.556). Based on the calculation, five additional novel compounds were designed and synthesized. Satisfyingly, compound 4u displayed excellent herbicidal activity (94.7%) at 1500 g/ha, although it is less active than 2,4-D. Meanwhile, this compound also exhibited good fungicidal activity against C. orbiculare (Berk aLMont) Arx (82.16%). PMID:21816005

  15. Alpha-emitting isotopes and chromium in a coastal California aquifer

    Highlights: • Alluvium in Piedra de Lumbre basin higher radionuclides likely from natural Th. • Natural uranium decay-chain isotopes, including Ra, present in marine deposits. • Marine deposits also contain low concentrations of chromium. • Radionuclides and chromium concentrations lower in alluvium in the Las Flores basin. - Abstract: The unadjusted 72-h gross alpha activities in water from two wells completed in marine and alluvial deposits in a coastal southern California aquifer 40 km north of San Diego were 15 and 25 picoCuries per liter (pCi/L). Although activities were below the Maximum Contaminant Level (MCL) of 15 pCi/L, when adjusted for uranium activity; there is concern that new wells in the area may exceed MCLs, or that future regulations may limit water use from the wells. Coupled well-bore flow and depth-dependent water-quality data collected from the wells in 2011 (with analyses for isotopes within the uranium, actinium, and thorium decay-chains) show gross alpha activity in marine deposits is associated with decay of naturally-occurring 238U and its daughter 234U. Radon activities in marine deposits were as high as 2230 pCi/L. In contrast, gross alpha activities in overlying alluvium within the Piedra de Lumbre watershed, eroded from the nearby San Onofre Hills, were associated with decay of 232Th, including its daughter 224Ra. Radon activities in alluvium from Piedra de Lumbre of 450 pCi/L were lower than in marine deposits. Chromium VI concentrations in marine deposits were less than the California MCL of 10 μg/L (effective July 1, 2014) but δ53Cr compositions were near zero and within reported ranges for anthropogenic chromium. Alluvial deposits from the nearby Las Flores watershed, which drains a larger area having diverse geology, has low alpha activities and chromium as a result of geologic and geochemical conditions and may be more promising for future water-supply development

  16. Synthesis, coordination and biological aspects of organotin(IV) derivatives of 4-[(2,4-dinitrophenyl)amino)]-4-oxo-2-butenoic acid and 2-{[(2,4-dinitrophenyl)amino]carbonyl}benzoic acid

    KHADIJA SHAHID; SAIRA SHAHZADI; SAQIB ALI

    2009-01-01

    New series of organotin(IV) complexes of aniline derivatives, R2SnL2 and R3SnL [where R = Me, n-Bu, Ph, n-Oct] have been synthesized by the reaction of HL1 and HL2 with respective organotin halides or oxides. Experimental details for the preparation and characterization (including elemental analysis, IR and multinuclear NMR (1H-, 13C- and 119Sn-) spectra in CDCl3 and EI mass spectra of both series are provided. The binding sites of the ligands were identified by means of FTIR spectroscopic me...

  17. Synthesis, coordination and biological aspects of organotin(IV derivatives of 4-[(2,4-dinitrophenylamino]-4-oxo-2-butenoic acid and 2-{[(2,4-dinitrophenylamino]carbonyl}benzoic acid

    KHADIJA SHAHID

    2009-02-01

    Full Text Available New series of organotin(IV complexes of aniline derivatives, R2SnL2 and R3SnL [where R = Me, n-Bu, Ph, n-Oct] have been synthesized by the reaction of HL1 and HL2 with respective organotin halides or oxides. Experimental details for the preparation and characterization (including elemental analysis, IR and multinuclear NMR (1H-, 13C- and 119Sn- spectra in CDCl3 and EI mass spectra of both series are provided. The binding sites of the ligands were identified by means of FTIR spectroscopic measurements. It was found that in all cases the organotin(IV moiety reacts with the oxygen of COO– group to form new complexes. In the diorganotin complexes, the COO– group is coordinated to the organotin(IV centres in a bidentate manner in the solid state. The 119Sn NMR data and the nJ(13C‑119/117Sn coupling constant support the tetrahedral coordination geometry of the organotin complexes in non-coordinating solvents. Biological activities (antibacterial, antifungal, cytotoxicity, antileishmanial and insecticidal of these compounds are also reported.

  18. Volumetric Behavior of the Ternary System Benzene – 2-Methoxy-2-Methylbutane – 2,2,4-Trimethylpentane and All Binary Sub-Systems at Temperature Range (298.15 – 318.15) K

    Houšková, Hana; Morávková, Lenka; Sedláková, Zuzana; Boublík, T.; Kolská, Z.

    2013-01-01

    Roč. 337, JAN 15 (2013), s. 156-164. ISSN 0378-3812 Grant ostatní: GA ČR(CZ) GAP108/10/1106 Institutional support: RVO:67985858 Keywords : vibrating-tube densimeter * excess molar volume * Peng–Robinson equation Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 2.241, year: 2013

  19. Book Review: The future of spacetime. Stephen William Hawking (ed.); Kip S. Thorne, Igor Novikov, Timothy Ferris, Alan Lightman, and Richard Price, W.W. Norton & Company, 2002, 224 pp., US 25.95, ISBN 0393020223

    Smeenk, Chris

    The study of Einstein's theory of general relativity experienced a renaissance beginning in the early 1960s. Prior to this resurgence of interest, general relativity was isolated from mainstream physics-admired for its elegance, perhaps, but only from a distance. The generation of students who risked their careers by entering this neglected field has now reached the age of festschrifts. In June of 2000, Caltech hosted "Kipfest," a conference in honor of Kip Thorne's 60th birthday. Thorne started graduate school at Princeton in 1962 and began research in general relativity under John Wheeler's guidance in the heady early days of the renaissance. Since then, he has played a prominent role in general relativity: as co-author of the influential textbook Gravitation, as a leader in research regarding astrophysical applications of Einstein's theory, and as a co-founder and chief advocate for the Laser Interferometer Gravitational Wave Observatory (LIGO), to mention a few aspects of his far-reaching work. "Kipfest" included 14 speakers discussing fields to which Thorne has contributed. But the conference also reflected Thorne's long-standing commitment to communicating science to a general audience: Igor Novikov, Stephen Hawking, Timothy Ferris, and Alan Lightman gave popular talks at "Kipfest," with Thorne himself tricked into delivering a fifth. The Future of Spacetime gathers adaptations of these five lectures, along with a lengthy introductory essay by Richard Price.

  20. Keystone Symposia "ncRNAs in Development and Cancer", Vancouver, Canada: Increased release of exosomes and export of invasion-modulating miRNAs miR921, -23b, -and -224 from metastatic urothelial carcinoma cells

    Ostenfeld, Marie Stampe; Jeppesen, Dennis Kjølhede; Laurberg, Jens Reumert;

    2013-01-01

    Cancer cells secrete soluble factors and various extracellular vesicles, including exosomes, into their tissue microenvironment. The secretion of exosomes is speculated to facilitate local invasion and increase the propensity of tumors to form distant metastases. Here we present a characterization...... of exosome vesicles from isogenic urothelial carcinoma cell lines, with different metastatic propensity by western blotting, electron microscopy, nanoparticle tracking analysis, dynamic light scattering, and profiling of 671 miRNAs by qRT-PCR. An increase in the number of multivesicular bodies and exosomes...... was observed for metastatic FL3 cells compared to isogenic non-metastatic T24 cells. The release was significantly inhibited by knockdown of Rab27b and pharmacological inhibition of nsmase2 by GW4869. miRNA profiling was conducted on parental cells and their secreted exosomes. Here, selective export of miR921...

  1. Andrea Ostrov, Espacios de ficción. Espacio, poder y escritura en la literatura latinoamericana : Villa María (Córdoba), EDUVIM, 2014, 224 páginas

    Rodríguez Pérsico, Adriana

    2015-01-01

    Para empezar, una serie de coincidencias felices. El título del libro de Andrea Ostrov, Espacios de ficción. Espacio, poder y escritura en la literatura latinoamericana, encastra de forma casi perfecta en el título de la colección que dirige Roxana Patiño, Zona crítica. Se trata, entonces, de espacios y de zonas, de ficción y de crítica. De pensar espacios para la reflexión crítica que derivan en preguntas ineludibles: ¿qué espacio hay hoy para la crítica?, ¿qué zonas ficcionales o reales som...

  2. VLT/UVES observations of extremely strong intervening damped Lyman-alpha systems: Molecular hydrogen and excited carbon, oxygen and silicon at log N(HI)=22.4

    Noterdaeme, P; Rahmani, H; Petitjean, P; Pâris, I; Ledoux, C; Gupta, N; López, S

    2015-01-01

    We present a detailed analysis of three extremely strong intervening DLAs (log N(HI)>=21.7) observed towards quasars with VLT/UVES. We measure overall metallicities of [Zn/H]~-1.2, -1.3 and -0.7 at respectively zabs=2.34 towards SDSS J2140-0321 (log N(HI) = 22.4+/-0.1), zabs=3.35 towards SDSS J1456+1609 (log N(HI) = 21.7+/-0.1) and zabs=2.25 towards SDSS J0154+1935 (log N(HI) = 21.75+/-0.15). We detect H2 towards J2140-0321 (log N(H2) = 20.13+/-0.07) and J1456+1609 (log N(H2) = 17.10+/-0.09) and argue for a tentative detection towards J0154+1935. Absorption from the excited fine-structure levels of OI, CI and SiII are detected in the system towards J2140-0321, that has the largest HI column density detected so far in an intervening DLA. This is the first detection of OI fine-structure lines in a QSO-DLA, that also provides us a rare possibility to study the chemical abundances of less abundant atoms like Co and Ge. Simple single phase photo-ionisation models fail to reproduce all the observed quantities. Inst...

  3. Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice

    Fantegrossi, William E; Gray, Bradley W; Bailey, Jessica M;

    2015-01-01

    characterized. OBJECTIVE: 25CN-NBOH was compared to the traditional phenethylamine hallucinogen R(-)-2,5-dimethoxy-4-iodoamphetamine (DOI) using mouse models of drug-elicited head twitch behavior and drug discrimination. METHODS: Drug-elicited head twitches were quantified for 10 min following administration...... of various doses of either DOI or 25CN-NBOH, with and without pretreatments of 0.01 mg/kg 5-HT2A antagonist M100907 or 3.0 mg/kg 5-HT2C antagonist RS102221. The capacity of 25CN-NBOH to attenuate DOI-elicited head twitch was also investigated. Mice were trained to discriminate DOI or M100907 from saline......, and 25CN-NBOH was tested for generalization. RESULTS: 25CN-NBOH induced a head twitch response in the mouse that was lower in magnitude than that of DOI, blocked by M100907, but not altered by RS102221. DOI-elicited head twitch was dose-dependently attenuated by 25CN-NBOH pretreatment. 25CN-NBOH produced...

  4. Visual Symmetry. By Magdolna Hargittai and István Hargittai, World Scientific Publishing, 2009; 224 pages. Price: US$ 48 / £ 36 ISBN 978-981-283-531-4

    Shu-Kun Lin

    2009-01-01

    Symmetry is as simple or as complicated as we are ready to absorb it in everything around us. From flowers to bridges, buildings, coke machines, and snowflakes; from molecules to walnuts, fences, pine cones, and sunflowers; from music to children's drawings; from hubcaps to bank logos, propellers, wallpaper decorations, and pavements, we recognize it if we walk around with open eyes and an open mind. This book provides aesthetic pleasure and covert education, immersing the reader in both the ...

  5. Visual Symmetry. By Magdolna Hargittai and István Hargittai, World Scientific Publishing, 2009; 224 pages. Price: US$ 48 / £ 36 ISBN 978-981-283-531-4

    Shu-Kun Lin

    2009-10-01

    Full Text Available Symmetry is as simple or as complicated as we are ready to absorb it in everything around us. From flowers to bridges, buildings, coke machines, and snowflakes; from molecules to walnuts, fences, pine cones, and sunflowers; from music to children's drawings; from hubcaps to bank logos, propellers, wallpaper decorations, and pavements, we recognize it if we walk around with open eyes and an open mind. This book provides aesthetic pleasure and covert education, immersing the reader in both the familiar and the unknown and leading always to unexpected discoveries.

  6. (2RS)-2-(2,4-Difluorophenyl)-1-[(4-iodobenzyl)(methyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

    Hui-Ping Xiong; Shou-Hong Gao; Chun-Tong Li; Zhi-Jun Wu

    2012-01-01

    In the title compound (common name: iodiconazole), C19H19F2IN4O, there is an intramolecular O—H...N hydrogen bond and molecules are linked by weak interactions only, namely C—H...N, C—H...O and C—H...F hydrogen bonds, and π-electron ring–π-electron ring interactions between the triazole rings with centroid–centroid distances of 3.725 (3) Å.

  7. APPLET Works life duration: predictive, performance and probabilistic approach. L2-2/4 - Bibliographic synthesis of the modelling of the interaction between the corrosion phenomenon and the steel/concrete interface

    After having described the problems raised by corrosion and the behaviour of degraded structures, this report addresses the issue of the steel/concrete interface. It presents the main adhesion tests, describes the various phenomenological aspects of a corrosion-free interface (degradation mechanism, impacting factors) and of corrosion mechanisms (impact of corrosion). The different corrosion modelling approaches are presented (life duration conceptual models, corrosion kinetics models), and then models describing the bond phenomenon. It finally proposes a critical analysis of interface models

  8. Carlos Raúl Hernández, Agonía de la democracia. ¿A dónde va Venezuela con la "revolución bolivariana”, Caracas, Panapo, 2001, 224 pp.

    Langue, Frédérique

    2005-01-01

    Desde el mes de abril de 2002 y el intento de golpe de Estado, la llamada revolución bolivariana se ha vendido enfrentando con unos cuestionamientos más radicales. Este libro, publicado antes de que se multiplicaran las protestas y otras formas de "desobediencia civil, permite abordar este proceso desde la perspectiva de las ideologías y de las creencias, vistas por un sociólogo que desde hace varios años, ha centrado su reflexión en torno a los temas de la democracia, de la libertad y del ca...

  9. Design, synthesis, and in vitro antifungal activity of 1-[(4-substituted-benzyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols.

    Guillon, Rémi; Pagniez, Fabrice; Giraud, Francis; Crépin, Damien; Picot, Carine; Le Borgne, Marc; Morio, Florent; Duflos, Muriel; Logé, Cédric; Le Pape, Patrice

    2011-05-01

    As part of our studies focused on the design of 1-[((hetero)aryl- and piperidinylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents, we report the development of new extended benzylamine derivatives substituted at the para position by sulfonamide or retrosulfonamide groups linked to alkyl or aryl chains. These molecules have broad-spectrum antifungal activities not only against Candida spp., including fluconazole-resistant strains, but also against a filamentous species (A. fumigatus). Concerning fluconazole resistance, selected compounds exhibit the capacity to overcome CDR and ERG11 gene upregulation and to maintain antifungal activity despite a recognized critical CYP51 substitution in C. albicans isolates. Synthesis, investigation of the mechanism of action by sterol analysis in a C. albicans strain, and structure-activity relationships (SARs) are reported. PMID:21370476

  10. Dussel, Inés y Caruso, Marcelo. La invención del aula. Una genealogía de las formas de enseñar : Santillana, Buenos Aires, 1999, 224 páginas

    Morras, Valeria

    2006-01-01

    Inés Dussel y Marcelo Caruso al asumir una mirada genealógica, realizan un recorrido histórico, sin pretensiones de neutralidad, sobre la configuración del aula de clase como espacio educativo privilegiado y las prácticas pedagógicas que en ella se llevan a cabo. La intención es desnaturalizar el aula. Se proponen “interrogar lo obvio”, “saber por qué el aula es como es”, por qué se realizan dentro de ella determinados discursos y prácticas: de dónde surgen, cuáles son sus significados y efec...

  11. Atenção farmacêutica para pacientes hipertensos – nova metodologia e a importância dessa prática no acompanhamento domiciliar - 10.5020/18061230.2008.p224

    Valdomiro Vagner de Souza; Ana Lúcia Francisco Bertoncin

    2012-01-01

    Objetivo: Avaliar e ampliar o conhecimento dos pacientes sobre a hipertensão arterial, buscando orientá-los e estimulá-los ao uso correto dos medicamentos e à adesão a estilo de vida adequado, salientando a importância da atenção farmacêutica domiciliar no tratamento da doença. Métodos: Estudo prospectivo, experimental e longitudinal, realizado com 10 pacientes hipertensos de uma farmácia municipal, selecionados aleatoriamente. Dados sobre os hábitos de vida, medicamentos uti izados e resulta...

  12. I. The metabolic properties of plutonium and allied materials

    Hamilton, J.G.

    1948-05-24

    This report on the metabolic properties of plutonium and related radioactive materials presents experimental information in the following areas: radioautographic studies; tracer studies (with tables of accumulation in tissues) of actinium, radio-zirconium, technetium, radio-rubidium, radio-germanium, beryllium, and cadmium; decontamination and bone metabolism studies; and radio-chemical isolation.

  13. Sorption studies of radioelements on geological materials

    Batch sorption experiments have been carried out to study the sorption of uranium, technetium, curium, neptunium, actinium, protactinium, polonium, americium and plutonium onto bentonite, granodiorite and tuff. Mathematical modelling using the HARPHRQ program and the HATCHES database was carried out to predict the speciation of uranium and technetium in the equilibrated seawater, and neptunium, americium and plutonium in the rock equilibrated water. Review of the literature for thermodynamic data for curium, actinium, protactinium and polonium was carried out. Where sufficient data were available, predictions of the speciation and solubility were made. This report is a summary report of the experimental work conducted by AEA Technology during April 1991-March 1998, and the main results have been presented at Material Research Society Symposium Proceedings and published as proceedings of them. (author)

  14. Investigation for determining the retention properties of rock over the ASSE II mine for dissolved radionuclides

    For a model consideration of groundwater movement and the associated transport of dissolved substance in deep groundwater, the retention properties of the ASSE II mine for radionuclides dissolved in water were determined. A series of properties of rocks were examined and described for this purpose. Apart from the chemical, mineralogical and petrophysical characteristics of the rocks, the retention was determined by 3 different methods and stated in the form of distribution coefficients for specific elements. A comparison of the results of vibration and diffusion experiments gave good agreement, while the results in through column experiments only reached the same order of magnitude after an expensive determination with the aid of a place concentration distribution. The distribution coefficients for the elements carbon, selenium, strontium, technetium, iodine, caesium, lead, radium, actinium, proto-actinium, uranium, neptunium, plutonium, americium and curium are listed and collected for model rock packages. (orig./HP)

  15. AcEST: DK949201 [AcEST

    Full Text Available = 165/224 (73%), Positives = 173/224 (77%) Frame = +1 Query: 1 VTLPNDPDLVDILAMNGVDISVSEGETNNSXXXXX...SG 388 Score = 39.7 bits (91), Expect = 0.017 Identities = 23/34 (67%), Positives...802), Expect = 6e-85 Identities = 166/224 (74%), Positives = 170/224 (75%) Frame ...: 342 APCIVFIDEIDAVGRQRGAGMGGGNDEREQTINQLLTEMDGFSG 385 Score = 39.7 bits (91), Expect = 0.017 Identities = 23/34 (67%), Positives...=2 SV=1 Length = 706 Score = 312 bits (800), Expect = 1e-84 Identities = 165/224 (73%), Positives = 170/224

  16. Sorption studies of radioelements on geological materials

    Berry, J. A; 油井 三和; 北村 暁

    2007-01-01

    Batch sorption experiments have been carried out to study the sorption of uranium, technetium, curium, neptunium, actinium, protactinium, polonium, americium and plutonium onto bentonite, granodiorite and tuff. Mathematical modelling using the HARPHRQ program and the HATCHES database was carried out to predict the speciation of uranium and technetium in the equilibrated seawater, and neptunium, americium and plutonium in the rock equilibrated water. Review of the literature for thermodynamic ...

  17. Purification of cerium, neodymium and gadolinium for low background experiments

    Boiko R.S.; Barabash A.S.; Belli P.; Bernabei R.; Cappella F.; Cerulli R.; Danevich F.A.; Incicchitti A.; Laubenstein M.; Mokina V.M.; Nisi S.; Poda D.V.; Polischuk O.G.; Tretyak V.I.

    2014-01-01

    Cerium, neodymium and gadolinium contain double beta active isotopes. The most interesting are 150Nd and 160Gd (promising for 0ν2β search), 136Ce (2β+ candidate with one of the highest Q2β). The main problem of compounds containing lanthanide elements is their high radioactive contamination by uranium, radium, actinium and thorium. The new generation 2β experiments require development of methods for a deep purification of lanthanides from the radioactive elements. A combination of physical an...

  18. LASL experience in decontamination of the environment

    This discussion represents one part of a major effort in soil decontamination at the Los Alamos site. A contaminated industrial waste line in the Los Alamos townsite was removed, and a plutonium incineration facility, and a filter building contaminated with actinium-227 were dismantled. The former plutonium handling facility has been decontaminated, and canyons and an old firing site contaminated with strontium-90 have been surveyed

  19. Study of the origin of elements of the uranium-235 family observed in excess in the vicinity of the experimental nuclear EL4 reactor under dismantling. Lessons got at this day and conclusions; Etude de l'origine des elements de la famille de l'uranium-235 observes en exces dans les environs du reacteur nucleaire experimental EL4 en cours de demantelement. Enseignements retires a ce jour et conclusion

    NONE

    2007-07-01

    This study resumes the discovery of an excess of actinium 227 found around by EL4 nuclear reactor actually in dismantling. The search for the origin of this excess revealed a real inquiry of investigation during three years. Because a nuclear reactor existed in this area a particular attention will have concerned this region. The doubt became the line of conduct to find the answer to the human or natural origin of this excess. Finally and against any evidence, it appears that the origin of this phenomenon was natural, consequence of the particular local geology. The detail of the different investigations is given: search of a possible correlation with the composition of elevations constituent of lanes, search (and underlining) of new sites in the surroundings of the Rusquec pond and the Plouenez station, study of the atmospheric deposits under winds of the nuclear power plant and in the east direction, search of a possible relationship with the gaseous effluents of the nuclear power plant in the past, historical study of radioactive effluents releases in the fifty last years by the analysis of the sedimentary deposits in the Saint-Herbiot reservoir, search of a possible correlation between the excess of actinium 227 and the nuclear power plant activity; search of a possible correlation with a human activity without any relationship with the nuclear activities, search of a correlation with the underground waters, search of a correlation with the geological context, collect of information on the possible transfers in direction of the food chain, determination of the radiological composition of the underground waters ( not perturbed by human activity), search of the cause of an excess of actinium 227 in the old channel of liquid effluents release of the nuclear power plant. The results are given and discussed. And contrary to all expectations the origin of the excess of actinium 227 is completely natural. (N.C.)

  20. The discoveries of uranium 237 and symmetric fission — From the archival papers of Nishina and Kimura

    IKEDA, Nagao

    2011-01-01

    Shortly before the Second World War time, Nishina reported on a series of prominent nuclear physical and radiochemical studies in collaboration with Kimura. They artificially produced 231Th, a member of the natural actinium series of nuclides, by bombarding thorium with fast neutrons. This resulted in the discovery of 237U, a new isotope of uranium, by bombarding uranium with fast neutrons, and confirmed that 237U disintegrates into element 93 with a mass number of 237. They also identified t...

  1. History of the unraveling of the natural decay series

    Milestones in the subject of radioactivity, which were important to the unraveling of natural decay series, have been identified and described. The interplay between all these issues is very complex, and some aspects of the development of the uranium series is discussed as an example, the thorium and actinium series evolved in a similar way from research by many of the same people. All three series as understood in 1913 are compared with their present-day representation. (orig.)

  2. History of the unraveling of the natural decay series

    Milestones in the subject of radioactivity, which were important to the unraveling of natural decay series, have been identified and described. The interplay between all these issues is very complex, and some aspects of the development of the uranium series is discussed as an example, the thorium and actinium series evolved in a similar way from research by many of the same people. All three series as understood in 1913 are compared with their present-day representation. (author)

  3. System for recovery of daughter isotopes from a source material

    Tranter, Troy J [Idaho Falls, ID; Todd, Terry A [Aberdeen, ID; Lewis, Leroy C [Idaho Falls, ID; Henscheid, Joseph P [Idaho Falls, ID

    2009-08-04

    A method of separating isotopes from a mixture containing at least two isotopes in a solution is disclosed. A first isotope is precipitated and is collected from the solution. A daughter isotope is generated and collected from the first isotope. The invention includes a method of producing an actinium-225/bismuth-213 product from a material containing thorium-229 and thorium-232. A solution is formed containing nitric acid and the material containing thorium-229 and thorium-232, and iodate is added to form a thorium iodate precipitate. A supernatant is separated from the thorium iodate precipitate and a second volume of nitric acid is added to the thorium iodate precipitate. The thorium iodate precipitate is stored and a decay product comprising actinium-225 and bismuth-213 is generated in the second volume of nitric acid, which is then separated from the thorium iodate precipitate, filtered, and treated using at least one chromatographic procedure. A system for producing an actinium-225/bismuth-213 product is also disclosed.

  4. Behaviour of uranium series radionuclides in surface water (Crouzille, Limousin). Geochemical implications

    Understanding natural radionuclides behaviour in surface water is a required step to achieve uranium mine rehabilitation and preserve water quality. The first objective of this thesis is to determine which are the radionuclides sources in a drinking water reservoir. The second objective is to improve the knowledge about the behaviour of uranium series radionuclides, especially actinium. The investigated site is a brook (Sagnes, Limousin, France) which floods a peat bog contaminated by a former uranium mine and which empties into the Crouzille lake. It allows studying radionuclides transport in surface water and radionuclides retention through organic substance or water reservoir. Radionuclides distribution in particulate, colloidal and dissolved phases is determined thanks to ultra-filtrations. Gamma spectrometry allows measuring almost all natural radionuclides with only two counting stages. However, low activities of 235U series radionuclides impose the use of very low background well-type Ge detectors, such as those of the Underground Laboratory of Modane (France). Firstly, this study shows that no or few radionuclides are released by the Sagnes peat bog, although its radioactivity is important. Secondly, it provides details on the behaviour of uranium series radionuclides in surface water. More specifically, it provides the first indications of actinium solubility in surface water. Actinium's behaviour is very close to uranium's even if it is a little less soluble. (author)

  5. Пинг Ж. Затмение в Африке: нужно ли было убивать Каддафи? – Париж: Издательство «Мишалон», 2014 – 224 с. (Ping J. Eclipse sur l’Afrique: fallait-il tuer Kadhafi? – Paris: Michalon Editeur, 2014 – 224 p.)

    Кривенкова, Ольга Владимировна

    2016-01-01

    Книга Жана Пинга «Затмение в Африке: нужно ли было убивать Каддафи?», опубликованная в Париже в 2014 г., посвящена событиям гражданской войны в Ливии и международной операции/ Бывший министр иностранных дел Габона (1999-2008 гг.), председатель Комиссии Африканского союза (2008-2013 гг.), автор являлся не только свидетелем разжегшегося в Ливии конфликта, но принимал непосредственное участие в попытках мирного урегулирования ливийского кризиса, будучи членом делегации АС, направленной на перего...

  6. Dicty_cDB: Contig-U12768-1 [Dicty_cDB

    Full Text Available 165 ggngttncnanggccncatnaaangccnatcccctttangaaancnatccntcaggnggn 224 ||||||||||||||||||||||||||||||||||||||...|||||||||||||||||||||| Sbjct: 165 ggngttncnanggccncatnaaangccnatcccctttangaaancnatccntcaggnggn 224 Query: 225 gaaaatccna...|||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 225 gaaaatccnatttatnctagccccnattancngtaanaacttttnaaaat...ccatnaaaac 284 Query: 285 ccccnactcaaacccc 300 |||||||||||||||| Sbjct: 285 ccccnactcaaacccc 300 >Contig-U127...||||||||||||| ||| Sbjct: 99 gcccttggggtntttatttttgntggnaaaaaaggttntgnctactggaaancnanncaa 158 Query: 165 ggngttncnanggccncatnaaangccna

  7. United Leukodystrophy Foundation

    ... matters. Please make your tax-deductible gift today! United Leukodystrophy Foundation 224 N. Second Street, Suite 2 ... validation purposes and should be left unchanged. Copyright © United Leukodystrophy Foundation, Inc. 224 North Second Street, Suite ...

  8. Dicty_cDB: Contig-U15560-1 [Dicty_cDB

    Full Text Available ilyqytnfini*kkkkkklknlt*ifqllsefnsikdryi Frame B: tspttlttcsksstsynptttitsttiasttnatttnatttnatttnatttnatnatt... = e-124 Identities = 224/224 (100%) Strand = Plus / Plus Query: 896 atattcaaacatttttagatttctcatcatttgactcttctattccaatgtcttctc...cat 955 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 896 atattcaaacatttttagatttctcatc...atttgactcttctattccaatgtcttctccat 955 Query: 956 caaccaactctcaacctcataatatacact...ataataattttaataaccctcaacagcaag 1015 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct

  9. 49 CFR Table 2 of Subpart B to... - Minimum Quantity Requirement for Retroreflective Sheeting on Freight Rolling Stock

    2010-10-01

    ... Sheeting on Freight Rolling Stock 2 Table 2 of Subpart B to Part 224 Transportation Other Regulations... REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK Pt. 224, Subpt. B, Table 2 Table 2 of Subpart B to Part 224—Minimum Quantity Requirement for Retroreflective Sheeting on Freight Rolling Stock Freight car or locomotive...

  10. « Communities in Place and Communities in Space. Globalization and Féminism in Iran », in : Parvin Alizadeh, ed., The Economy of Iran: Dilemmas of an Islamic State. London - New York, Tauris, 2002, pp. 215-224.

    Ladier-Fouladi, Marie

    2006-01-01

    Dans cet article, l’A. propose de montrer en premier lieu qu’en dépit de la politique discriminatoire de la République islamique, le statut de la femme s’est amélioré depuis 1979. En second lieu, il tente de déterminer les facteurs à l’origine de cette évolution. Pour l’A., la diffusion de l’école à une échelle géographique de plus en plus étendue et notamment l’accroissement du niveau d’instruction scolaire des femmes d’une part, et la globalisation, d’autre part, constituent les deux facteu...

  11. Hidden Cameras: Everything You Need to Know About Covert Recording, Undercover Cameras and Secret Filming Plomin Joe Hidden Cameras: Everything You Need to Know About Covert Recording, Undercover Cameras and Secret Filming 224pp £12.99 Jessica Kingsley 9781849056434 1849056439 [Formula: see text].

    2016-08-01

    Last year, the Care Quality Commission issued guidance to families on using hidden cameras if they are concerned that their relatives are being abused or receiving poor care. The author was the undercover producer who exposed the abuse at Winterbourne View, near Bristol, in 2011 for BBC's Panorama. PMID:27484558

  12. Just 224 large donations from fewer than 60 sources accounted for two fifths of the donation income of the top three parties across a decade of British politics. This is far too narrow a base for the health of UK democracy

    Wilks-Heeg, Stuart

    2010-01-01

    Why has reform of party funding in the UK been so troublesome for the body politic and steps to clean up the process so inadequate and hesitant? Using an in-depth analysis of party finances Stuart Wilks-Heeg exposes the myth that many small donors keep the major parties afloat. Instead he shows that the top three parties rely on attracting an average of just ten or eleven large donations a year between them from a tiny group of rich people, plus a few companies and large trade unions. This na...

  13. Bis[μ-2-(2,4-difluorophenyl-1,3-bis(1,2,4-triazol-1-ylpropan-2-olato-κ4N2,O:O,N2′]bis[(acetato-κ2O,O′nickel(II] methanol hemisolvate

    Feng Zhang

    2010-01-01

    Full Text Available In the title complex, [Ni2(C13H11F2N6O2(C2H3O22]·0.5CH3OH, there are two half-molecules in the asymmetric unit. The two centrosymmetrically related NiII atoms, each attached to an acetate ligand, are linked by two fluconazole ligands. Each NiII atom is six-coordinated in a distorted octahedral geometry by two N atoms of the triazole groups and two bridging O atoms from two different fluconazole ligands and two O atoms from a chelating acetate ligand. In the crystal structure, the half-occupied methanol solvent molecule is linked to a triazole group via an O—H...N hydrogen bond.

  14. Éléments d'hydromorphologie fluviale. Édité par l'Onema (Office national de l'eau et des milieux aquatiques, 2010, 224 p.En ligne sur : http://www.onema.fr/hydromorphologie-fluviale.

    Jean-René Malavoi

    2011-02-01

    Full Text Available Le texte ci-dessous reproduit, à quelques détails près, le résumé qui accompagne l'ouvrage :Torrents, ruisseaux, rivières, fleuves, estuaires, deltas, autant de termes qui illustrent l'immense variété des cours d'eau qui sillonnent le territoire. Méandres, tresses, chutes, rapides, bras morts, chenaux, autant de caractéristiques visuelles qui nous sont familières alors même que nous n'en connaissons pas l'origine. Elles résultent en réalité de la combinaison subtile d'une quantité de caractéristiques naturelles ou non qui marquent le cours d'eau sur son passage : la nature de la roche mère dans laquelle il creuse son lit, le climat et la pente qui lui donnent sa puissance ou encore les activités humaines qui modifient son débit.L'ouvrage dévoile l'extraordinaire complexité des phénomènes mis en jeu dans la "fabrication" des cours d'eau. Il fait découvrir l'hydromorphologie fluviale, véritable discipline scientifique contemporaine, et explicite les caractéristiques géomorphologiques du lit mineur ou du lit majeur d'un cours d'eau, qui vont conditionner les grands types d'habitat pour les espèces aquatiques et terrestres qui en dépendent. Il apparaît ainsi que le bon fonctionnement écologique des cours d'eau et de leur corridor passe par la préservation et la restauration des processus géodynamiques naturels ainsi que des caractéristiques géomorphologiques qui leur sont associées.Quelques 400 illustrations combinant photographies et schémas explicitent ce que l'œil humain ne peut saisir et permettent d'approcher les différentes échelles auxquelles les phénomènes s'expriment, du galet jusqu'au bassin versant entier, voire au territoire.L'hydromorphologie fluviale s'avère aujourd'hui indispensable pour guider les orientations de gestion et de restauration des cours d'eau.

  15. Michel Griffon - Qu’est ce que l’agriculture écologiquement intensive ? - Édition Quae 2013, Collection : Matière à débattre et décider, 224 pages

    Duru, Michel

    2014-01-01

    Les concepts clés Une première manière de s’approprier le contenu de cet ouvrage est d’examiner le lexique. Les mots clés les plus fréquemment référencés sont : biodiversité, énergie, fertilité, fonctionnalités, paysage. La plupart seront familiers aux lecteurs. Ils fournissent déjà des indications sur ce qu’est l’agriculture écologiquement intensive : elle est basée sur la biodiversité ; elle permet de réduire la consommation d’énergie, notamment en conséquence de l’augmentation de la fertil...

  16. DISSOLVED CONCENTRATION LIMITS OF RADIOACTIVE ELEMENTS

    P. Bernot

    2005-07-13

    The purpose of this study is to evaluate dissolved concentration limits (also referred to as solubility limits) of elements with radioactive isotopes under probable repository conditions, based on geochemical modeling calculations using geochemical modeling tools, thermodynamic databases, field measurements, and laboratory experiments. The scope of this activity is to predict dissolved concentrations or solubility limits for elements with radioactive isotopes (actinium, americium, carbon, cesium, iodine, lead, neptunium, plutonium, protactinium, radium, strontium, technetium, thorium, and uranium) relevant to calculated dose. Model outputs for uranium, plutonium, neptunium, thorium, americium, and protactinium are provided in the form of tabulated functions with pH and log fCO{sub 2} as independent variables, plus one or more uncertainty terms. The solubility limits for the remaining elements are either in the form of distributions or single values. Even though selection of an appropriate set of radionuclides documented in Radionuclide Screening (BSC 2002 [DIRS 160059]) includes actinium, transport of Ac is not modeled in the total system performance assessment for the license application (TSPA-LA) model because of its extremely short half-life. Actinium dose is calculated in the TSPA-LA by assuming secular equilibrium with {sup 231}Pa (Section 6.10); therefore, Ac is not analyzed in this report. The output data from this report are fundamental inputs for TSPA-LA used to determine the estimated release of these elements from waste packages and the engineered barrier system. Consistent modeling approaches and environmental conditions were used to develop solubility models for the actinides discussed in this report. These models cover broad ranges of environmental conditions so they are applicable to both waste packages and the invert. Uncertainties from thermodynamic data, water chemistry, temperature variation, and activity coefficients have been quantified or

  17. DISSOLVED CONCENTRATION LIMITS OF RADIOACTIVE ELEMENTS

    The purpose of this study is to evaluate dissolved concentration limits (also referred to as solubility limits) of elements with radioactive isotopes under probable repository conditions, based on geochemical modeling calculations using geochemical modeling tools, thermodynamic databases, field measurements, and laboratory experiments. The scope of this activity is to predict dissolved concentrations or solubility limits for elements with radioactive isotopes (actinium, americium, carbon, cesium, iodine, lead, neptunium, plutonium, protactinium, radium, strontium, technetium, thorium, and uranium) relevant to calculated dose. Model outputs for uranium, plutonium, neptunium, thorium, americium, and protactinium are provided in the form of tabulated functions with pH and log fCO2 as independent variables, plus one or more uncertainty terms. The solubility limits for the remaining elements are either in the form of distributions or single values. Even though selection of an appropriate set of radionuclides documented in Radionuclide Screening (BSC 2002 [DIRS 160059]) includes actinium, transport of Ac is not modeled in the total system performance assessment for the license application (TSPA-LA) model because of its extremely short half-life. Actinium dose is calculated in the TSPA-LA by assuming secular equilibrium with 231Pa (Section 6.10); therefore, Ac is not analyzed in this report. The output data from this report are fundamental inputs for TSPA-LA used to determine the estimated release of these elements from waste packages and the engineered barrier system. Consistent modeling approaches and environmental conditions were used to develop solubility models for the actinides discussed in this report. These models cover broad ranges of environmental conditions so they are applicable to both waste packages and the invert. Uncertainties from thermodynamic data, water chemistry, temperature variation, and activity coefficients have been quantified or otherwise

  18. Detection of rare earth elements in Powder River Basin sub-bituminous coal ash using laser-induced breakdown spectroscopy (LIBS)

    Tran, Phuoc [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State; Mcintyre, Dustin [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State

    2015-10-01

    We reported our preliminary results on the use of laser-induced breakdown spectroscopy to analyze the rare earth elements contained in ash samples from Powder River Basin sub-bituminous coal (PRB-coal). We have identified many elements in the lanthanide series (cerium, europium, holmium, lanthanum, lutetium, praseodymium, promethium, samarium, terbium, ytterbium) and some elements in the actinide series (actinium, thorium, uranium, plutonium, berkelium, californium) in the ash samples. In addition, various metals were also seen to present in the ash samples

  19. A Novel Chemically Modified Curcumin “Normalizes” Wound-Healing in Rats with Experimentally Induced Type I Diabetes: Initial Studies

    Zhang, Yazhou; McClain, Steve A.; Lee, Hsi-Ming; Elburki, Muna S.; Yu, Huiwen; Gu, Ying; Zhang, Yu; Wolff, Mark; Johnson, Francis; Golub, Lorne M.

    2016-01-01

    Introduction. Impaired wound-healing in diabetics can lead to life-threatening complications, such as limb amputation, associated in part with excessive matrix metalloproteinase- (MMP-) mediated degradation of collagen and other matrix constituents. In the current study, a novel triketonic chemically modified curcumin, CMC2.24, was tested for efficacy in healing of standardized skin wounds in streptozotocin-induced diabetic rats. Initially, CMC2.24 was daily applied topically at 1% or 3% concentrations or administered systemically (oral intubation; 30 mg/kg); controls received vehicle treatment only. Over 7 days, the diabetics exhibited impaired wound closure, assessed by gross and histologic measurements, compared to the nondiabetic controls. All drug treatments significantly improved wound closure with efficacy ratings as follows: 1% 2.24 > systemic 2.24 > 3% 2.24 with no effect on the severe hyperglycemia. In subsequent experiments, 1% CMC2.24 “normalized” wound-healing in the diabetics, whereas 1% curcumin was no more effective than 0.25% CMC2.24, and the latter remained 34% worse than normal. MMP-8 was increased 10-fold in the diabetic wounds and topically applied 1% (but not 0.25%) CMC2.24 significantly reduced this excessive collagenase-2; MMP-13/collagenase-3 did not show significant changes. Additional studies indicated efficacy of 1% CMC2.24 over more prolonged periods of time up to 30 days.

  20. Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cells

    Turner, Stephen J.; La Gruta, Nicole L.; Stambas, John; Diaz, Gabriela; Doherty, Peter C.

    2004-01-01

    Much of the CD8+ T cell response in H2b mice with influenza pneumonia is directed at the nucleoprotein366-374 (NP366) and acid polymerase224-233 (PA224) peptides presented by the H2Db MHC class I glycoprotein. These DbNP366- and DbPA224-specific T cell populations are readily analyzed by staining with tetrameric complexes of MHC+ peptide (tetramers) or by cytokine production subsequent to in vitro stimulation with the cognate peptides. The DbPA224-specific CD8+ effector T cells make more tumo...

  1. 78 FR 17719 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    2013-03-22

    ... Ave., Columbia, 13000172 Newton County Neosho Wholesale Grocery Company, 224 N. Washington St., Neosho... Jackson County Buffington Island Battlefield (Boundary Increase), Roughly bounded by Ohio River, Dry...

  2. An aerial radiological survey of the Sandia National Laboratories and surrounding area

    A team from the Remote Sensing Laboratory conducted an aerial radiological survey of the area surrounding the Sandia National Laboratories and Kirtland Air Force Base in Albuquerque, New Mexico, during March and April 1993. The survey team measured the terrestrial gamma radiation at the site to determine the levels of natural and man-made radiation. This survey includes the areas covered by a previous survey in 1981. The results of the aerial survey show a background exposure rate which varies between 5 and 18 μR/h plus an approximate 6 μR/h contribution from cosmic rays. The major radioactive isotopes found in this survey were: potassium-40, thallium-208, bismuth-214, and actinium-228, which are all naturally-occurring isotopes, and cobalt-60, cesium-137, and excess amounts of thallium-208 and actinium-228, which are due to human actions in the survey area. In regions away from man-made activity, the exposure rates inferred from this survey's gamma ray measurements agree almost exactly with the exposure rates inferred from the 1981 survey. In addition to the aerial measurements, another survey team conducted in situ and soil sample radiation measurements at three sites within the survey perimeter. These ground-based measurements agree with the aerial measurements within ± 5%

  3. Mixed valency of the RE and Ac ions in solid states

    Full text: This review is devoted to consideration of the methods and results of the theoretical and experimental investigations of the electronic state of the rare earths and actinium ions in the separate compound. The methods of the high resolution X ray spectroscopy were used for our consideration. Energy of the X ray lines of the rare earths and actinium ions in free state and solid states was study carefully. Valency shifts of X Ray lines under change of electronic state of nf - ions in different oxide, fluoride and chloride compounds were determined for K -, L- and M - lines for these ions with accuracy near 10 -100 MeV. We studied the electronic state of nf- ions which is changed from '+2' to '+4' and determined the concentration of ions in different electronic state. Relative error for theoretical energy of the most lines for HFP - approach in comparison with experiment is less than 0.5%, and deviation for concentration is less than 5%

  4. A study of uranium and thorium migration at the Koongarra uranium deposit with application to actinide transport from nuclear waste repositories

    One way to gain confidence in modelling possible radionuclide releases is to study natural systems which are similar to components of the multibarrier waste repository. Several such analogues are currently under study and these provide useful data about radionuclide behaviour in the natural environment. One such system is the Koongarra uranium deposit in the Northern Territory. In this dissertation, the migration of actinides, primarily uranium and thorium, has been studied as an analogue for the behaviour of transuranics in the far-field of a waste repository. The major findings of this study are: 1. the main process retarding uranium migration in the dispersion fan at Koongarra is sorption, which suppresses dissolved uranium concentrations well below solubility limits, with ferrihydrite being a major sorbing phase; 2. thorium is extremely immobile, with very low dissolved concentrations and corresponding high distribution ratios for 230Th. Overall, it is estimated that colloids are relatively unimportant in Koongarra groundwater. Uranium migrates mostly as dissolved species, whereas thorium and actinium are mostly adsorbed to larger, relatively immobile particles and the stationary phase. However, of the small amount of 230Th that passes through a 1μm filter, a significant proportion is associated with colloidal particles. Actinium appears to be slightly more mobile than thorium and is associated with colloids to a greater extent, although generally present in low concentrations. These results support the possibility of colloidal transport of trivalent and tetravalent actinides in the vicinity of a nuclear waste repository. 112 refs., 23 tabs., 32 figs

  5. Purification of cerium, neodymium and gadolinium for low background experiments

    Boiko R.S.

    2014-01-01

    Full Text Available Cerium, neodymium and gadolinium contain double beta active isotopes. The most interesting are 150Nd and 160Gd (promising for 0ν2β search, 136Ce (2β+ candidate with one of the highest Q2β. The main problem of compounds containing lanthanide elements is their high radioactive contamination by uranium, radium, actinium and thorium. The new generation 2β experiments require development of methods for a deep purification of lanthanides from the radioactive elements. A combination of physical and chemical methods was applied to purify cerium, neodymium and gadolinium. Liquid-liquid extraction technique was used to remove traces of Th and U from neodymium, gadolinium and for purification of cerium from Th, U, Ra and K. Co-precipitation and recrystallization methods were utilized for further reduction of the impurities. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe gamma spectrometry. As a result of the purification procedure the radioactive contamination of gadolinium oxide (a similar purification efficiency was reached also with cerium and neodymium oxides was decreased from 0.12 Bq/kg to 0.007 Bq/kg in 228Th, from 0.04 Bq/kg to <0.006 Bq/kg in 226Ra, and from 0.9 Bq/kg to 0.04 Bq/kg in 40K. The purification methods are much less efficient for chemically very similar radioactive elements like actinium, lanthanum and lutetium.

  6. The Technological Enhancement of Normally Occurring Radioactive Materials in Red Mud due to the Production of Alumina

    Maurice O. Miller

    2016-01-01

    Full Text Available This study investigates the level of technological enhancement of normally occurring radioactive materials (TENORM in the red mud waste due to the production of alumina in Jamaica. Technological enhancements factors (TEF were determined for the uranium, thorium, actinium series, their progenies, and the nonseries potassium-40 using gamma spectrometry. The study concluded that bauxite production technologically enhances the uranium progenies Th-234, Pb-214, Bi-214, and Pa-234 and the thorium-232 progenies Ac-228, Pb-212, and Bi-212 in red mud. The actinium series was technologically enhanced, but K-40 and the thorium daughter, Tl-208, were reduced. The spectrometric comparison of Tl-208 (at 510 keV was unexpected since its other photopeaks at 583 keV, 934 keV, and 968 keV were markedly different. An explanation for this anomaly is discussed. An explanation regarding the process of accumulation and fractionation of organically derived phosphate deposits and potassium-feldspar is offered to explain the spectrometric differences between the alumina product and its waste material, red mud.

  7. Low background counting of 222Rn, 220Rn and 219Rn with electrostatic counters

    Mong, Brian; EXO-200 Collaboration; nEXO Collaboration

    2014-09-01

    The radon counting technique based on electrostatic precipitation of progenies in gas followed by alpha spectroscopy has been applied to support the material selection programs of low background, neutrino and dark matter experiments with emphasis on EXO. An array of 8 counters operated by Laurentian University at SNOLAB and the Waste Isolation Pilot Plant have reached the sensitivity of 10 atoms/day in the uranium, thorium and actinium chains. Hardware improvements are underway to further increase the capacity and sensitivity in support of nEXO. The radon counting technique based on electrostatic precipitation of progenies in gas followed by alpha spectroscopy has been applied to support the material selection programs of low background, neutrino and dark matter experiments with emphasis on EXO. An array of 8 counters operated by Laurentian University at SNOLAB and the Waste Isolation Pilot Plant have reached the sensitivity of 10 atoms/day in the uranium, thorium and actinium chains. Hardware improvements are underway to further increase the capacity and sensitivity in support of nEXO. Supported by NSERC Project Grants ``Search for Double Beta Decay with EXO.''

  8. Purification of cerium, neodymium and gadolinium for low background experiments

    Boiko, R. S.; Barabash, A. S.; Belli, P.; Bernabei, R.; Cappella, F.; Cerulli, R.; Danevich, F. A.; Incicchitti, A.; Laubenstein, M.; Mokina, V. M.; Nisi, S.; Poda, D. V.; Polischuk, O. G.; Tretyak, V. I.

    2014-01-01

    Cerium, neodymium and gadolinium contain double beta active isotopes. The most interesting are 150Nd and 160Gd (promising for 0ν2β search), 136Ce (2β+ candidate with one of the highest Q2β). The main problem of compounds containing lanthanide elements is their high radioactive contamination by uranium, radium, actinium and thorium. The new generation 2β experiments require development of methods for a deep purification of lanthanides from the radioactive elements. A combination of physical and chemical methods was applied to purify cerium, neodymium and gadolinium. Liquid-liquid extraction technique was used to remove traces of Th and U from neodymium, gadolinium and for purification of cerium from Th, U, Ra and K. Co-precipitation and recrystallization methods were utilized for further reduction of the impurities. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe gamma spectrometry. As a result of the purification procedure the radioactive contamination of gadolinium oxide (a similar purification efficiency was reached also with cerium and neodymium oxides) was decreased from 0.12 Bq/kg to 0.007 Bq/kg in 228Th, from 0.04 Bq/kg to <0.006 Bq/kg in 226Ra, and from 0.9 Bq/kg to 0.04 Bq/kg in 40K. The purification methods are much less efficient for chemically very similar radioactive elements like actinium, lanthanum and lutetium.

  9. Does bank failure affect client firms? Micro evidence from Estonia

    Joeveer, Karin

    -, č. 224 (2004), s. 1-29. ISSN 1211-3298 Institutional research plan: CEZ:AV0Z7085904 Keywords : bank failure * client firm performance * firm bankruptcy Subject RIV: AH - Economics http://www.cerge-ei.cz/pdf/wp/Wp224.pdf

  10. 75 FR 53681 - Office of Elementary and Secondary Education Overview Information; Advanced Placement (AP) Test...

    2010-09-01

    ... address: Francisco Ramirez, U.S. Department of Education, 400 Maryland Avenue, SW., Room 3E224, Washington, DC 20202-6200. Telephone: (202) 260-1541 or by e-mail: francisco.ramirez@ed.gov . If you use a...: Francisco Ramirez, U.S. Department of Education, 400 Maryland Avenue, SW., Room 3E224, Washington, DC...

  11. Acyclic nucleoside bisphosphonates as inhibitors of hypoxanthine-guanine-(xanthine) phosphoribosyltransferases: Potential new anti-malarial compounds

    Špaček, Petr; Hocková, Dana; Janeba, Zlatko; Vrbková, Silvie; Edstein, M.; de Jersey, J.; Keough, D. T.; Guddat, L. W.

    Amsterdam : Elsevier, 2012. P2.24-P2.24. [Tetrahedron Symposium: Challenges in Bioorganic & Organic Medicinal Chemistry /13./. 26.06.2012-29.06.2012, Amsterdam] Institutional research plan: CEZ:AV0Z40550506 Keywords : nucleoside phosphonates * biophosphonates Subject RIV: CC - Organic Chemistry

  12. Classical Iterative Methods

    Axelsson, Owe

    1. Berlin, Heidelberg: Springer-Verlag, 2013 - (Björm, E.), s. 205-224 ISBN 978-3-540-70528-4 Institutional support: RVO:68145535 Keywords : classical iterative methods * applied computational mathematics * encyclopedia Subject RIV: BA - General Mathematics http://www.springerreference.com/docs/ navigation .do?m=Encyclopedia+of+Applied+and+Computational+Mathematics+%28Mathematics+and+Statistics%29-book224

  13. Commemoration as Conflict: Space, Memory and Identity in Peace Processes

    McQuaid, Sara Dybris

    2015-01-01

    Book rewiew: Commemoration as Conflict: Space, Memory and Identity in Peace Processes / Sara McDowell and Maire Braniff Palgrave Macmillan, 2014, 224pp., ISBN 978-0-230-27375-7......Book rewiew: Commemoration as Conflict: Space, Memory and Identity in Peace Processes / Sara McDowell and Maire Braniff Palgrave Macmillan, 2014, 224pp., ISBN 978-0-230-27375-7...

  14. AcEST: DK962966 [AcEST

    Full Text Available TST39A01NGRL0015_E09 653 Adiantum capillus-veneris mRNA. clone: TST39A01NGRL0015_E09. 5' end seq ... = 112/143 (78%) Frame = +2 Query: 224 PEIVKAGDPILIEPA PPVPVAEITSPRIQQIIKNMITLMRAVPAVGVAAPQIGIPLQIIV 403 P ... = 109/143 (76%) Frame = +2 Query: 224 PEIVKAGDPILIEPA PPVPVAEITSPRIQQIIKNMITLMRAVPAVGVAAPQIGIPLQIIV 403 P ...

  15. Predictive Value of Morphological Features in Patients with Autism versus Normal Controls

    Ozgen, H.; Hellemann, G. S.; de Jonge, M. V.; Beemer, F. A.; van Engeland, H.

    2013-01-01

    We investigated the predictive power of morphological features in 224 autistic patients and 224 matched-pairs controls. To assess the relationship between the morphological features and autism, we used the receiver operator curves (ROC). In addition, we used recursive partitioning (RP) to determine

  16. Influence of carbon fibres on the surface properties of composite materials for medical applications

    Stodolak, E.; Blazewicz, M.; Grausová, Ľubica

    Krakow : Wydawnictwo Naukowe Akapit, 2007. s. 224-224. ISBN 978-83-89541-95-6. [International Conference CESEP´07 - Carbon for Energy Storage and Environment Protection /2./. 02.09.2007-06.09.2007, Krakow] Keywords : spo2 * biomaterials * surface topography * wettability Subject RIV: EI - Biotechnology ; Bionics

  17. Drug: D07321 [KEGG MEDICUS

    Full Text Available D07321 Drug Vinylbital (INN); Vinylbitone C11H16N2O3 224.1161 224.2563 D07321.gif A...HOLEPTICS N05C HYPNOTICS AND SEDATIVES N05CA Barbiturates, plain N05CA08 Vinylbital D07321 Vinylbital (INN)

  18. Effects of mutagenesis of aspartic acid residues in the putative phosphoribosyl diphosphate binding site of Escherichia coli phosphoribosyl diphosphate synthetase on metal ion specificity and ribose-5-phosphate binding

    Willemoës, Martin; Nilsson, Dan; Hove-Jensen, Bjarne

    1996-01-01

    The three conserved aspartic acid residues of the 5-phospho-d-ribosyl a-1-diphosphate binding site (213-GRDCVLVDDMIDTGGT-228) of Escherichia coli phosphoribosyl diphosphate synthetase were studied by analysis of the mutant enzymes D220E, D220F, D221A, D224A, and D224S. The mutant enzymes showed a...

  19. The measurement of triclosan in water using a magnetic particle enzyme immunoassay

    A sensitive magnetic particle-based immunoassay to determine triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) in drinking water and wastewater was developed. Rabbit antiserum was produced by immunizing the rabbit with 6-(5-chloro-2-(2,4-dichlorophenoxy)phenoxy)hexanoic acid-keyhole limpet hemocya...

  20. Selvoplevet og sand, men mest det første

    Haarder, Jon Helt

    2007-01-01

    Lars Saabye Christensen: SAABYES CIRKUS (Oversat fra norsk af Karsten Sand Iversen) 224 sider, 229 kr. Athene UDKOMMER I DAG Udgivelsesdato: 14.09......Lars Saabye Christensen: SAABYES CIRKUS (Oversat fra norsk af Karsten Sand Iversen) 224 sider, 229 kr. Athene UDKOMMER I DAG Udgivelsesdato: 14.09...

  1. A novel antagonist anti-cMet antibody with antitumor activities targeting both ligand-dependent and ligand-independent c-Met receptors.

    Gonzalez, Alexandra; Broussas, Matthieu; Beau-Larvor, Charlotte; Haeuw, Jean-François; Boute, Nicolas; Robert, Alain; Champion, Thierry; Beck, Alain; Bailly, Christian; Corvaïa, Nathalie; Goetsch, Liliane

    2016-10-15

    c-Met is a prototypic member of a sub-family of RTKs. Inappropriate c-Met activation plays a crucial role in tumor formation, proliferation and metastasis. Using a key c-Met dimerization assay, a set of 12 murine whole IgG1 monoclonal antibodies was selected and a lead candidate, m224G11, was humanized by CDR-grafting and engineered to generate a divalent full antagonist humanized IgG1 antibody, hz224G11. Neither m224G11 nor hz224G11 bind to the murine c-Met receptor. Their antitumor activity was investigated in vitro in a set of experiments consistent with the reported pleiotropic effects mediated by c-Met and, in vivo, using several human tumor xenograft models. Both m224G11 and hz224G11 exhibited nanomolar affinities for the receptor and inhibited HGF binding, c-Met phosphorylation, and receptor dimerization in a similar fashion, resulting in a profound inhibition of all c-Met functions in vitro. These effects were presumably responsible for the inhibition of c-Met's major functions including cell proliferation, migration, invasion scattering, morphogenesis and angiogenesis. In addition to these in vitro properties, hz224G11 dramatically inhibits the growth of autocrine, partially autophosphorylated and c-Met amplified cell lines in vivo. Pharmacological studies performed on Hs746T gastric cancer xenografts demonstrate that hz224G11 strongly downregulates c-Met expression and phosphorylation. It also decreases the tumor mitotic index (Ki67) and induces apoptosis. Taken together, the in vitro and in vivo data suggest that hz224G11 is a promising candidate for the treatment of tumors. This antibody, now known as ABT-700 and currently in Phase I clinical trials, may provide a novel therapeutic approach to c-Met-expressing cancers. PMID:27144973

  2. Purification system of gram-amount neptunium using anion exchange chromatography

    To develop a purification system of gram-amount neptunium using anion exchange chromatography, adsorption elution of excess amount of actinium in 6M HNO3 aqueous solution was studied using thorium and uranium tracer. The partition coefficient (Kd) of Th (IV) decreased from Kd=99.1 of tracer to Kd=44.0, 5% load. By decreasing the partition coefficient, we can wash until 30 Vs under the purification conditions of 1% load and 95% recovery. The retention volume of U (IV) was about 300 Vs, a large value. The partition coefficient of Np (IV) may be larger than it and the large amount of washable eluting solution may be obtained. Washing of impurity of 3d transition metal and actinide (VI) can be done until 20Vs. With washing of 150Vs, impurity of alkali earth metal, metals (III) and platinum group metals decreased less than 0.1%. (S.Y.)

  3. A francium-223 reservoir source

    By improving and accelerating a method which had been earlier tried for caesium-rubidium separation on a cellulose column, i.e. elution with 2N HCl-equilibrated phenol, the author succeeded in obtaining consecutive and quasi-selective elutions of francium-223, starting with actinium-227 fixed at the top of a small cellulose column to which ZrO2 had been added. The francium-223, rapidly eluted under pressure, is extracted by water while the phenol is extracted by ether; it can easily be cleared of any residual traces of radioactive contaminants (thallium-207, radium-223, thorium-227) by two consecutive BaSO4 precipitations. The preparation of a Fr223 solution (HCl-H2SO4) requires approximately 20 min; the time noted for Fr223 was closer to 22 than to 21 min. (author)

  4. Radionuclide interactions with marine sediments

    A critical review of the literature on the subject of the interactions of radionuclides with marine sediments has been carried out. On the basis of the information available, an attempt has been made to give ranges and 'best estimates' for the distribution ratios between seawater and sediments. These estimates have been based on an understanding of the sediment seawater system and the porewater chemistry and mineralogy. Field measurements, laboratory measurements and estimates based on stable-element geochemical data are all taken into account. Laboratory measurements include distribution-ratio and diffusion-coefficient determinations. The elements reviewed are carbon, chlorine, calcium, nickel, selenium, strontium, zirconium, niobium, technetium, tin, iodine, caesium, lead, radium, actinium, thorium, protactinium, uranium, neptunium, plutonium, americium and curium. (author)

  5. Formerly utilized MED/AEC sites Remedial Action Program. Radiological survey of the St. Louis Airport Storage Site, St. Louis, Missouri. Final report

    Results of two radiological surveys of the St. Louis-Lambert Airport property, formerly known as the Airport Storage Site, St. Louis, Missouri, are presented. Uranium- and radium-bearing waste materials were stored from the 1940's to the late 1960's in this area. The surveys included direct measurements of beta-gamma radiation; determination of uranium, actinium, and radium concentrations in soil samples and from bore holes; determination of radionuclide concentrations in groundwater and surface water; measurement of radon flux from the ground surface; and measurements of 222Rn in air near the site. Results indicate that some offsite drainage pathways are becoming contaminated, probably by runoff from the site; no migration of 222Rn from the site was observed

  6. JAEA thermodynamic database for performance assessment of geological disposal of high-level and TRU wastes. Refinement of thermodynamic data for trivalent actinoids and samarium

    Within the scope of the JAEA thermodynamic database project for performance assessment of geological disposal of high-level radioactive and TRU wastes, the refinement of the thermodynamic data for the inorganic compounds and complexes of trivalent actinoids (actinium(III), plutonium(III), americium(III) and curium(III)) and samarium(III) was carried out. Refinement of thermodynamic data for these elements was based on the thermodynamic database for americium published by the Nuclear Energy Agency in the Organisation for Economic Co-operation and Development (OECD/NEA). Based on the similarity of chemical properties among trivalent actinoids and samarium, complementary thermodynamic data for their species expected under the geological disposal conditions were selected to complete the thermodynamic data set for the performance assessment of geological disposal of radioactive wastes. (author)

  7. Theoretical Study on Properties of New Isotope 265Bh

    2006-01-01

    The properties of nuclei belonging to the newly observed α-decay chain starting from 265Bh have been studied. The axially deformed relativistic mean-field calculation with the force NL-Z2 has been performed in the blockedBCS approximation. Some ground state properties such as binding energies, deformations, spins, and parities, as well as Q-values of the α-decay for this decay chain have been calculated and compared with known experimental data. Good agreement is found. The single-particle spectrum of the nucleus 265 Bh is studied and some new magic numbers are found,while the magnitudes of the shell gaps in superheavy nuclei are much smaller than those of nuclei before the actinium region, and the Fermi surfaces are close to the continuum. Thus the superheavy nuclei are usually not stable. The The methods which give good agreement with the data are selected.

  8. Proposed training program for construction personnel involved in remedial action work at sites contaminated by naturally occurring radionuclides

    Many sites used during the early days of the US atomic energy program are contaminated with radionuclides of the primordial decay chains (uranium, thorium, and actinium series). This contamination consists of residues resulting from refining and processing uranium and thorium. Preparation of these sites for release to unrestricted private use will involve the assistance of construction workers, many of whom have limited knowledge of the hazards associated with radioactive materials. Therefore, there is a need to educate these workers in the fundamentals of radioactive material handling to minimize exposures and possible spread of contamination. This training should disseminate relevant information at an appropriate educational level and should instill a cautious, common-sense attitude toward the handling of radioactive materials. The training should emphasize basic information concerning environmental radiation within a context of relative risk. A multi-media format, including colorful visual aids, demonstration, and discussion, should be used to maximize motivation and retention. A detailed, proposed training program design is presented

  9. Analysis of Ancestral and Functionally Relevant CD5 Variants in Systemic Lupus Erythematosus Patients

    Maria Carmen Cenit; Mario Martínez-Florensa; Marta Consuegra; Lizette Bonet; Elena Carnero-Montoro; Noelia Armiger; Miguel Caballero-Baños; Maria Teresa Arias; Daniel Benitez; Norberto Ortego-Centeno; Enrique de Ramón; José Mario Sabio; García-Hernández, Francisco J; Carles Tolosa; Ana Suárez

    2014-01-01

    Objective: CD5 plays a crucial role in autoimmunity and is a well-established genetic risk factor of developing RA. Recently, evidence of positive selection has been provided for the CD5 Pro224-Val471 haplotype in East Asian populations. The aim of the present work was to further analyze the functional relevance of non-synonymous CD5 polymorphisms conforming the ancestral and the newly derived haplotypes (Pro224-Ala471 and Pro224-Val471, respectively) as well as to investigate the potential r...

  10. AcEST: DK954984 [AcEST

    Full Text Available TST39A01NGRL0021_O09 642 Adiantum capillus-veneris mRNA. clone: TST39A01NGRL0021_O09. 5' end seq ... (66%) Frame = +3 Query: 90 LSKKVEQTLEELGVQTKPKVPTQAVC AEHLELRKEILTMLNLKKQ 224 + K+ TL+ELG+ +P +P+ V EH +L ... 18 PRVFTRGALLTQLIQTVLPPGGARLSKKVEQTLEELGVQTKPKVPTQAVC AEHLELRKEI 197 P VF R A +T T P + K+ T +ELG+ +P +PT ... (66%) Frame = +3 Query: 90 LSKKVEQTLEELGVQTKPKVPTQAVC AEHLELRKEILTMLNLKKQ 224 + KV L+ELG+ +P +P+ AV H EL ... Frame = +3 Query: 69 LPPGGARLSKKVEQTLEELGVQTKPKVPTQAVC AEHLELRKEILTMLNLKKQ 224 +P A LS++V + ELGV ++ +PT + ...

  11. Distribution characteristics of radium isotopes and their influence factors in the water of Jiaozhou Bay area

    Background: The interaction between continental and oceanic process is much intense in coastal region. The terrestrial freshwater mixes with seawater here which leads to the chemical constituents in water undergo rapid change. Purpose: The aim is to analyze and study the distribution characteristics of 224Ra and 226Ra and their influence factors in the water of Jiaozhou Bay area. Methods: The water samples of 224Ra and 226Ra were collected from groundwater, river water and seawater around the Jiaozhou Bay from April to May, 2012. In the laboratory, the activities of 224Ra absorbed on the Mn-fiber were measured through the continuous emanation method. Finally, the Mn-fiber was sealed for more than 7 days, and the activities of 226Ra absorbed on the Mn-fiber were measured through the direct emanation method. Results: The results show that the activities of 224Ra and 226Ra in groundwater and river water are much higher in the granitic area which has higher concentration of 232Th and 238U. Because of mixing with seawater, the salinity of groundwater and river water in coastal region rises which leads to the increasing amounts of 224Ra and 226Ra desorbed from the particles, resulting in higher activities of 224Ra and 226Ra in coastal region. Affected by the input of river (dissolved and desorbed from suspended particles) and submarine groundwater discharge (SGD), the activities of 224Ra and 226Ra are relatively higher in nearshore seawater, then with the decay of 224Ra and mixing dilution effect of the offshore seawater, the activities of 224Ra gradually decrease from nearshore region to the open ocean. The activities of 226Ra in the seawater of Jiaozhou Bay remain high-level values, and there are only a few zones of low 226Ra activities. The main reasons are that the activities of 226Ra from terrestrial freshwater are close to those from offshore seawater and the half-life of 226Ra is very long. Conclusion: The activities of 224Ra and 226Ra in groundwater relate to the

  12. Alice Munro: A Bibliography

    Bigot, Corinne

    2014-01-01

    I. Collections of short stories by Alice Munro Dance of the Happy Shades, Toronto, Ryerson Press, 1968, 224 pp; New York, McGraw Hill, 1973, 224 pp; London, Allen Lane, 1974, 224 pp. Lives of Girls and Women, Toronto, McGraw Hill Ryerson, 1971, 254 pp; New York,McGraw Hill, 1972, 250 pp; London, Allen Lane, 1974, 250 pp. Something I’ve Been Meaning To Tell You, Toronto and New York, McGraw-Hill Ryerson, 1974, 246 pp. Who Do You Think You Are?, Toronto, Macmillan, 1974, 206 pp. Printed in the ...

  13. Radioactivity in hot spring water, Peitou, Taiwan and Taiwan earthquake in September, 1999

    Momoshima, N. [Kumamoto Univ. (Japan). Faculty of Science; Sugihara, S. [Kyushu Univ., Graduate School of Science, Fukuoka (Japan); Huang, C.W. [Chung Yuan Christian Univ., Department of Chemistry, TW (China); Wu, C.W. [National Taiwan Univ., Institute of Agriculture Chemistry, TW (China)

    2000-07-01

    Hot spring water sometimes contains high amounts of radioactivity. Peitou hot spring, located in north of Taipei, Taiwan, is well known its high concentrations of radium isotopes and production of rare radioactive rock, hokutolite. Substances dissolved in hot spring water would be useful tools to examine geochemical processes occurring under ground. Radionuclides in hot spring water give us an information about a time scale involved in the geochemical processes. We have analyzed concentrations of radionuclides in hot spring water to understand geochemical processes occurring at Peitou. Hot spring water was collected monthly at Peitou, Taiwan from September 1996. Radium isotopes in the hot spring water were co-precipitated with BaSO{sub 4}. The radioactivities in the BaSO{sub 4} were measured by gamma spectrometry. {sup 226}Ra, {sup 228}Ra and {sup 224}Ra concentrations were determined by concentrations of their daughter nuclides after attaining radioactive equilibrium. The concentrations of {sup 226}Ra were distributed in a range between 0.02 Bq/l and 0.05 Bq/l, showing a gradual decrease from September 1996 to July 1998 as a whole followed by a fairly constant period and it increased again from May 1999. The concentrations of {sup 228}Ra and {sup 224}Ra were distributed in ranges between 0.6 Bq/l and 1.2 Bq/l for {sup 228}Ra and between 3 Bq/l and 7.80 Bq/l for {sup 224}Ra, respectively. The concentrations of {sup 228}Ra and {sup 224}Ra were 2 or 3 orders magnitude higher compared to that of {sup 226}Ra. The Peitou hot spring water is rich in radium isotopes belonging to thorium decay series. The concentrations of {sup 228}Ra and {sup 224}Ra also changed a similar manner to {sup 226}Ra. A relatively large deviation from the gradual decline was observed on the sample collected on December 1997 and the sample taken just before the Taiwan earthquake in 21 September 1999 showed significant low concentrations. We observed higher concentration of {sup 224}Ra than {sup

  14. Radioactivity in hot spring water, Peitou, Taiwan and Taiwan earthquake in September, 1999

    Hot spring water sometimes contains high amounts of radioactivity. Peitou hot spring, located in north of Taipei, Taiwan, is well known its high concentrations of radium isotopes and production of rare radioactive rock, hokutolite. Substances dissolved in hot spring water would be useful tools to examine geochemical processes occurring under ground. Radionuclides in hot spring water give us an information about a time scale involved in the geochemical processes. We have analyzed concentrations of radionuclides in hot spring water to understand geochemical processes occurring at Peitou. Hot spring water was collected monthly at Peitou, Taiwan from September 1996. Radium isotopes in the hot spring water were co-precipitated with BaSO4. The radioactivities in the BaSO4 were measured by gamma spectrometry. 226Ra, 228Ra and 224Ra concentrations were determined by concentrations of their daughter nuclides after attaining radioactive equilibrium. The concentrations of 226Ra were distributed in a range between 0.02 Bq/l and 0.05 Bq/l, showing a gradual decrease from September 1996 to July 1998 as a whole followed by a fairly constant period and it increased again from May 1999. The concentrations of 228Ra and 224Ra were distributed in ranges between 0.6 Bq/l and 1.2 Bq/l for 228Ra and between 3 Bq/l and 7.80 Bq/l for 224Ra, respectively. The concentrations of 228Ra and 224Ra were 2 or 3 orders magnitude higher compared to that of 226Ra. The Peitou hot spring water is rich in radium isotopes belonging to thorium decay series. The concentrations of 228Ra and 224Ra also changed a similar manner to 226Ra. A relatively large deviation from the gradual decline was observed on the sample collected on December 1997 and the sample taken just before the Taiwan earthquake in 21 September 1999 showed significant low concentrations. We observed higher concentration of 224Ra than 228Ra. The activity ratio of 224Ra/228Ra far exceeded unity, more than 6, that is unusual because 224Ra and

  15. Origin of elements of the Uranium-235 family observed in the Ellez river near the EL-4 experimental nuclear reactor in dismantling (Monts d'Arree- Finistere department); Origine des elements de la famille de l'uranium-235 observes dans la riviere Ellez a proximite du reacteur nucleaire experimental EL4 en cours de demantelement (Mont d'Arree - departement du Finistere). Resultats et premiers constats annee 2006

    NONE

    2006-07-01

    In a previous study which concerned the catchment basin of the harbour of Brest, the A.C.R.O. put in evidence a marking by artificial radioelements around the power plant of Brennilis which can be imputed without ambiguities to the nuclear installation. It also put in evidence abnormalities concerning the natural radioactivity which justifies this new study. In the area of the Monts d'Arree, actinium 227 ({sup 227}Ac), non born by its ascendents which are {sup 235}U and {sup 231}Pa is observed. This phenomenon is characterized by mass activities superior to these ones of {sup 235}U and able to reach these ones of {sup 238}U. Its presence corresponds with the drainage of the Ellez river since the former channel of radioactive effluents releases from the nuclear power plant EL-4 up to the reservoir Saint-Herblot situated 6 km downstream. The strongest values of radioactivity are registered near the disused power plant, at this place a relationship exists between the level of actinium 227 and this one of the artificial radioactivity as it exists a relationship with the decay products of radon exhaled from the subsoil ({sup 210}Pb). But its presence is not limited to a part of the Ellez river, it is equally observed in terrestrial medium, in places in priori not influenced by the direct liquid effluents of the power plant. This place is situated at more than 4 km and without any connection with the Ellez waters. At this stage of the study, it is not possible to answer with certainty the question of the origin of this phenomenon. A new reorientation is considered indispensable to clarify definitively the origin of this unknown phenomenon in the scientific publications and the environmental monitoring. (N.C.)

  16. origin of elements of the Uranium-235 family observed in the Ellez river near the EL-4 experimental nuclear reactor in dismantling (Monts d'Arree- Finistere department)

    In a previous study which concerned the catchment basin of the harbour of Brest, the A.C.R.O. put in evidence a marking by artificial radioelements around the power plant of Brennilis which can be imputed without ambiguities to the nuclear installation. It also put in evidence abnormalities concerning the natural radioactivity which justifies this new study. In the area of the Monts d'Arree, actinium 227 (227Ac), non born by its ascendents which are 235U and 231Pa is observed. This phenomenon is characterized by mass activities superior to these ones of 235U and able to reach these ones of 238U. Its presence corresponds with the drainage of the Ellez river since the former channel of radioactive effluents releases from the nuclear power plant EL-4 up to the reservoir Saint-Herblot situated 6 km downstream. The strongest values of radioactivity are registered near the disused power plant, at this place a relationship exists between the level of actinium 227 and this one of the artificial radioactivity as it exists a relationship with the decay products of radon exhaled from the subsoil (210Pb). But its presence is not limited to a part of the Ellez river, it is equally observed in terrestrial medium, in places in priori not influenced by the direct liquid effluents of the power plant. This place is situated at more than 4 km and without any connection with the Ellez waters. At this stage of the study, it is not possible to answer with certainty the question of the origin of this phenomenon. A new reorientation is considered indispensable to clarify definitively the origin of this unknown phenomenon in the scientific publications and the environmental monitoring. (N.C.)

  17. Physical Measurements and Clinical Findings of Persons with Radium Burdens

    Results of physical measurements and some clinical findings of persons with radium burdens are reported and discussed. Ten workers of the dial painting industry, two chemists, who have been working for between 10 and 20 yr in the radium- industry, one technician, who has been- working for over 20 yr with high-emanation radium preparations and one person with high radium intake of rather unknown history were measured in a whole-body counter for evaluation of the body burdens of radium-226 and radium-228+ actinium-228. In some cases the radon concentration of expired air was also measured. For four of the measured persons the radium-226 burden is of the order of the maximum permissible amount (MPA : 10-7 c) or more. In one case the burden amounts to more than three times the MPA, (3.4 x 10-7 c), in another case to more than 100 times the MPA (160 x 10-7 c). In one case the radium-228 + actinium-228 burden exceeds the MPA (6 x 10-8 c in bone). The measured radon concentrations in the expired air were used to calculate the excretion rate of radon. The average was 67%. Clinical findings with some of the measured persons are related to the measured body burdens. The patient with the high body burden of 160 x 10-7 c radium-226 shows heavy bone changes leading to spontaneous bone fractures. The blood picture shows a decrease in the number of erythrocytes and a low haemoglobin content but puncture of the sternum indicates normal haematopoiesis. It seems that the low number of erythrocytes is caused by chronic nephropathia, the reason for which might be an additional intake of uranium because.uranium was found in the urine by gamma spectroscopy. The results are discussed with respect to the MPA of radium-226 recommended by the International Commission on Radiological Protection. (author)

  18. Assessment of UV-positive particles in extracts of the urban aerosol

    Kotlík, B.; Keder, J.; Kašička, Václav; Matějů, L.; Sázelová, Petra; Kazmarová, H.

    Thessaloniki: -, 2008. T06A224P. [European Aerosol Conference 2008. 24.08.2008-29.08.2008, Thessaloniki] Institutional research plan: CEZ:AV0Z40550506 Keywords : air pollution * bioaerosol * capillary electrophoresis Subject RIV: CB - Analytical Chemistry, Separation

  19. Dicty_cDB: Contig-U12489-1 [Dicty_cDB

    Full Text Available aaattcagtggtagtttctcatgttcatggattcaggttatactttaaatgtn 1894 Query: 1895 ataataaaaagtctt 1909 ||||||||||||||| Sbjct...||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 744 ggtnatttattgagtactgataaaaagacttgtacagataaaaatgaatgtttaact...: 832 gatataaatgaatgttcaactaataatgncggctgtagtcaagtttgtacaaatncagca 773 Query: 1141 ggtagtttct...catgttcatggattcaggttatactttaaatgtnataataaaaagtctt 1909 ||||||||||||||||||||| |||||||||||...||||||||||||||||||||||||||| Sbjct: 61 tggtagtttctcatgttcatgnattcaggttatactttaaatgtnataataaaaagtctt 2 Score = 224 bits (113), Expect

  20. Drug: D04338 [KEGG MEDICUS

    Full Text Available idual organs 22 Respiratory organ agents 224 Antitussives a...onium chloride [DR:D01139] Therapeutic category: 2249 Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting indiv

  1. 40 CFR 414.70 - Applicability; description of the bulk organic chemicals subcategory.

    2010-07-01

    ... *Alkylates *Alpha-Olefins Butane (all forms) *C-4 Hydrocarbons (Unsaturated) Calcium Stearate Caprolactam...-Ethylbutyraldehyde 2,2,4-Trimethyl-1,3-Pentanediol (b) Amine and Amide Organic Chemicals 2,4-Diaminotoluene...

  2. Chromatin modification of Notch targets in olfactory receptor neuron diversification

    Endo, K.; Karim, M. R.; Taniguchi, H.; Krejčí, Alena; Kinameri, E.; Siebert, M.; Ito, K.; Bray, S. J.; Moore, A. W.

    2012-01-01

    Roč. 15, č. 2 (2012), s. 224-233. ISSN 1097-6256 Institutional research plan: CEZ:AV0Z50070508 Keywords : neuron diversification Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 15.251, year: 2012

  3. Pediatric Palliative Care: A Personal Story

    Full Text Available ... count__/__total__ Find out why Close Pediatric Palliative Care: A Personal Story NINRnews Subscribe Subscribed Unsubscribe 224 ... and her family. The story demonstrates how palliative care can positively influence a patient's and family's experience ...

  4. Perissodactyla

    Červený, Jaroslav

    Farmington Hills : Gale, 2003 - (Kleiman, D.; Geist, V.; Hutchins, M.; McDade, M.), s. 215-224 ISBN 0-7876-6573-8 Institutional research plan: CEZ:AV0Z6093917 Keywords : Perissodactyla Subject RIV: EG - Zoology

  5. Disease: H00048 [KEGG MEDICUS

    Full Text Available on P. Cancer risk from occupational and environmental exposure to polycyclic arom...doses of radium-224. Radiat Res 152:S3-7 (1999) PMID:9498904 (carcinogen) Boffetta P, Jourenkova N, Gustavss

  6. Women and the labor market in the Czech Republic: transition from a socialist to a social-democratic regime?

    Hamplová, Dana

    Cheltenham : Edward Elgar Publishing, 2006 - (Blossfeld, H.; Hofmeister, H.), s. 224-246 ISBN 978 1 845426644 Institutional research plan: CEZ:AV0Z70280505 Keywords : mobility * women * labour market Subject RIV: AO - Sociology, Demography

  7. Efficacy of tepronone and folic acid in the treatment of chronic atrophic gastritis evaluated by the marking targeting biopsy

    裘力锋

    2013-01-01

    Objective To explore the efficacy of tepronone and folic acid in the treatment of chronic atrophic gastritis(CAG) evaluated by the marking targeting biopsy(MTB).Methods A total of 224 H.pylori negative

  8. The Case C-34/09 Ruiz Zambrano v. ONEm - the Timeless Judgment of the Court of Justice on EU Citizenship

    Hamerník, Pavel

    151/2, č. 9/3 TLQ (2012), s. 216-224. ISSN 0231-6625 Institutional support: RVO:68378122 Keywords : EU Citizenship * cross-border situations * third country nationals Subject RIV: AG - Legal Sciences

  9. Judicialization of International Relations: Do International Courts Matter?

    Malíř, Jan

    2013-01-01

    Roč. 3, č. 3 (2013), s. 208-224. ISSN 1805-8396 Institutional support: RVO:68378122 Keywords : judicialization * international relations * legal and extralegal factors Subject RIV: AG - Legal Sciences

  10. 17 CFR 242.402 - General provisions.

    2010-04-01

    ... Regulation T, U or X of the Board of Governors of the Federal Reserve System (12 CFR parts 220, 221, and 224...) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Customer...

  11. Optimization of the Timepix chip to measurement of radon, thoron and their progenies

    Janik, M.; Ploc, Ondřej; Fiederle, M.; Proc, S.; Kavasi, N.

    2016-01-01

    Roč. 107, JAN (2016), s. 220-224. ISSN 0969-8043 Institutional support: RVO:61389005 Keywords : Radon * Thoron * Timepix * calibration Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 1.231, year: 2014

  12. Příběhy žité a vyprávěné: od psychoterapie k identitě a epistemologii

    Čermák, Ivo

    Bratislava: KVSBK SAV, VEDA vydavatelství SAV, 2001, s. 77-92. ISBN 80-224-0702-X Institutional research plan: CEZ:AV0Z7025918 Keywords : Narrative identity * narrative epistemology * psychotherapy Subject RIV: AN - Psychology

  13. Historické nahrávky autentických forem chodské lidové hudby

    Vejvoda, Zdeněk

    Plzeň : Západočeská univerzita v Plzni, 2013, s. 215-224. ISBN 978-80-261-0328-8 Institutional support: RVO:68378076 Keywords : Chodsko * ethnomusicology * historical recordings Subject RIV: AC - Archeology, Anthropology, Ethnology

  14. Differentiation study between alfalfa mosaic virus and red clover mottle virus affecting broad bean by biological and molecular characterization

    Mahmoud, S.Y.M.; Khaled, A.-S.G.A.; Petrzik, Karel

    2010-01-01

    Roč. 6, č. 4 (2010), s. 224-239. ISSN 1816-4900 Institutional research plan: CEZ:AV0Z50510513 Keywords : identification * phylogenetic relationship * nucleotide sequences Subject RIV: EB - Genetics ; Molecular Biology

  15. Rudolf Geiger (Hrsg.), Völkerrechtlicher Vertrag und staatliches Recht vor dem Hintergrund zunehmender Verdichtung der internationalen Beziehungen, Symposion vom 28. - 30. Januar 1999 in Leipzig / [rezensiert von] Norman Weiß

    Weiß, Norman

    2000-01-01

    rezensiertes Werk: Geiger, Rudolf (Hrsg.): Völkerrechtlicher Vertrag und staatliches Recht vor dem Hintergrund zunehmender Verdichtung der internationalen Beziehungen, Symposion vom 28. - 30. Januar 1999. - Leipzig : NOMOS-Verl.-gesell., 2000. - 224 S. ISBN 3-7890-6476-9

  16. Methods for species delimitation in bumblebees (Hymenoptera, Apidae, Bombus): towards an integrative approach

    Lecocq, T.; Dellicour, S.; Michez, D.; Dehon, M.; Dewulf, A.; De Meulemeester, T.; Brasero, N.; Valterová, Irena; Rasplus, J. Y.; Rasmont, P.

    2015-01-01

    Roč. 44, č. 3 (2015), s. 281-297. ISSN 0300-3256 Institutional support: RVO:61388963 Keywords : bumblebee taxonomy * genetic analysis * pheromone composition Subject RIV: CC - Organic Chemistry Impact factor: 3.224, year: 2014

  17. Festivalipäevik III / Margaret Tali, Anu Allas, Margit Tõnson...[jt.

    2005-01-01

    Rahvusvaheline NU Performance festival "Continental Breakfast" Tallinnas Kanuti Gildi saalis 2.-24. nov. 2005. Hollandlase Kim H. Veltmani loengu formaadis performance "World tree". Katrin Essensoni performance "Designed to make difference". Gob Squad (Saksamaa/Inglismaa) "Super Night Shot".

  18. Prevalence of gestational diabetes mellitus, its associated risk factors and pregnancy outcomes at a rural setup in Central India

    Kanika R. Kalyani

    2014-02-01

    Conclusion: GDM adversely affects maternal and fetal outcomes and its prevalence is steadily rising. Appropriate interventions are required for its control. [Int J Reprod Contracept Obstet Gynecol 2014; 3(1.000: 219-224

  19. Dicty_cDB: FC-IC1465 [Dicty_cDB

    Full Text Available its) Value N ( AU272514 ) Dictyostelium discoideum gamete cDNA clone:FC-IC1... 232 2e-84 2 ( AU275020 ) Dictyostelium discoideum game...te cDNA clone:FC-IC1... 232 7e-57 1 ( AU275231 ) Dictyostelium discoideum gamete... cDNA clone:FC-IC1... 224 2e-54 1 ( AU275222 ) Dictyostelium discoideum gamete cDNA ...clone:FC-IC1... 224 2e-54 1 ( AU275176 ) Dictyostelium discoideum gamete cDNA clone:FC-IC1... 224 2e-54 1 ( ...AU275175 ) Dictyostelium discoideum gamete cDNA clone:FC-IC1... 224 2e-54 1 ( AU2

  20. Port Facilities - PORTS_NTAD_IN: Ports in Indiana derived from the U.S. Army Corps of Engineers (Bureau of Transportation Statistics, 1:100,000, Point Shapefile)

    NSGIC GIS Inventory (aka Ramona) — The U.S. Army Corps of Engineers (USACE) Ports database is an extract from the National Waterway Network database consisting of 224 points coded as U.S. Army Corps...

  1. Irenická idea - Irenej, Řehoř z Nyssy, Komenský a současnost

    Rajchl, Jaroslav

    2008-01-01

    Roč. 38, č. 80 (2008), s. 221-224. ISSN 0323-2220 Institutional research plan: CEZ:AV0Z10030501 Keywords : cross complementarity * triadicity * relations between members Subject RIV: AA - Philosophy ; Religion

  2. Sodium chloride, potassium chloride, and virulence in Listeria monocytogenes.

    MYERS, E. R.; Dallmier, A W; Martin, S E

    1993-01-01

    Virulence, as determined in a mouse model, and the virulence factor activities of catalase, superoxide dismutase, and listeriolysin O were examined in a parental strain (10403S) and in a nonhemolytic mutant strain (DP-L224) of Listeria monocytogenes. The cells were propagated in media containing various concentrations of sodium chloride or potassium chloride. Strains 10403S and DP-L224 exhibited significant increases in catalase activity and listeriolysin O activity when grown in medium conta...

  3. Effect of Symptoms of Adult Attention Deficit Hyperactivity Disorder on Symptoms of Post Traumatic Stress Disorder in Korean Conscripts

    Lee, Dong-Yun; Lee, Cheol-Soon; Park, Chul-Soo; Kim, Bong-Jo; Cha, Bo-Seok; Lee, So-Jin; Bhang, Soo Young

    2012-01-01

    Objective This study is conducted to investigate the effect of symptoms of Attention Deficit and Hyperactivity Disorder (ADHD) on symptoms of Posttraumatic Stress Disorder (PTSD) among 224 conscripts during 5 weeks of military basic training. Methods Total number of subject is 224 conscripts. We evaluated past and present symptoms of ADHD with Korean-Wender Utah rating scale (K-WURS) and Korean adult attention -deficit/hyperactivity disorder scale (K-AADHDS) and stress and symptoms of PTSD wi...

  4. Training-based Channel Estimation for Signal Equalization and OPM in 16-QAM Optical Transmission Systems

    Pittalà, Fabio; Hauske, Fabian N.; Ye, Yabin; Tafur Monroy, Idelfonso; Nossek, Josef A.

    2012-01-01

    Efficient channel estimation for signal equalization and OPM based on short CAZAC sequences with QPSK and 8PSK constellation formats is demonstrated in a 224-Gb/s PDM 16-QAM optical linear transmission system.......Efficient channel estimation for signal equalization and OPM based on short CAZAC sequences with QPSK and 8PSK constellation formats is demonstrated in a 224-Gb/s PDM 16-QAM optical linear transmission system....

  5. Anion-directed assembly and crystal transformation of Ag(I) coordination polymers with a versatile tripyridyltriazole ligand 3,4-bis(2-pyridyl)-5-(4-pyridyl)-1,2,4-triazole

    Li, Cheng-Peng; Chen, Jing; Guo, Wei; Du, Miao

    2015-03-01

    A series of distinct Ag(I) coordination polymers, namely {[Ag2(L224)(H2O)3](SiF6)(H2O)4}n (1), {[Ag2(L224)2(NO3)](NO3)(H2O)}n (3), {[Ag2(L224)(OOCC6H5)(H2O)](NO3)(H2O)2}n (4), and {[Ag(L224)2](CF3SO3)(H2O)0.25}n (5) have been synthesized by assembling a versatile ligand 3,4-bis(2-pyridyl)-5-(4-pyridyl)-1,2,4-triazole (L224) with different Ag(I) salts. Their diverse 1D and 2D coordination arrays indicate the critical role of counterions in structural assemblies. Interestingly, single-crystal-to-single-crystal (SC-SC) transformation from 1 to {[Ag2(L224)(CF3COO)2(H2O)](H2O)}n (2) will occur in the water solution of Ag(CF3COO). Structural comparison and mechanism of SC-SC transformation are discussed. These Ag(I) coordination polymers show enhanced ligand-based solid-state fluorescent emissions.

  6. Minor Actinide Burning in Thermal Reactors. A Report by the Working Party on Scientific Issues of Reactor Systems

    The actinides (or actinoids) are those elements in the periodic table from actinium upwards. Uranium (U) and plutonium (Pu) are two of the principal elements in nuclear fuel that could be classed as major actinides. The minor actinides are normally taken to be the triad of neptunium (Np), americium (Am) and curium (Cm). The combined masses of the remaining actinides (i.e. actinium, thorium, protactinium, berkelium, californium, einsteinium and fermium) are small enough to be regarded as very minor trace contaminants in nuclear fuel. Those elements above uranium in the periodic table are known collectively as the transuranics (TRUs). The operation of a nuclear reactor produces large quantities of irradiated fuel (sometimes referred to as spent fuel), which is either stored prior to eventual deep geological disposal or reprocessed to enable actinide recycling. A modern light water reactor (LWR) of 1 GWe capacity will typically discharge about 20-25 tonnes of irradiated fuel per year of operation. About 93-94% of the mass of uranium oxide irradiated fuel is comprised of uranium (mostly 238U), with about 4-5% fission products and ∼1% plutonium. About 0.1-0.2% of the mass is comprised of neptunium, americium and curium. These latter elements accumulate in nuclear fuel because of neutron captures, and they contribute significantly to decay heat loading and neutron output, as well as to the overall radio-toxic hazard of spent fuel. Although the total minor actinide mass is relatively small - approximately 20-25 kg per year from a 1 GWe LWR - it has a disproportionate impact on spent fuel disposal, and thus the longstanding interest in transmuting these actinides either by fission (to fission products) or neutron capture in order to reduce their impact on the back end of the fuel cycle. The combined masses of the trace actinides actinium, thorium, protactinium, berkelium and californium in irradiated LWR fuel are only about 2 parts per billion, which is far too low for

  7. A slowly accreting ~10 Myr old transitional disk in Orion OB1a

    Espaillat, C; Hernández, J; Briceño, C; Calvet, N; D'Alessio, P; McClure, M; Watson, D M; Hartmann, L; Sargent, B

    2008-01-01

    Here we present the Spitzer IRS spectrum of CVSO 224, the sole transitional disk located within the ~10 Myr old 25 Orionis group in Orion OB1a. A model fit to the spectral energy distribution of this object indicates a ~7 AU inner disk hole that contains a small amount of optically thin dust. In previous studies, CVSO 224 had been classified as a weak-line T Tauri star based on its Halpha equivalent width, but here we find an accretion rate of 7x10^-11 Msun/yr based on high-resolution Hectochelle data. CVSO 224's low mass accretion rate is in line with photoevaporative clearing theories. However, the Spitzer IRS spectrum of CVSO 224 has a substantial mid-infrared excess beyond 20microns which indicates that it is surrounded by a massive outer disk. Millimeter measurements are necessary to constrain the mass of the outer disk around CVSO 224 in order to confirm that photoevaporation is not the mechanism behind creating its inner disk hole.

  8. TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

    As part of its commitment to clean up Cold War legacy sites, the U.S. Department of Energy (DOE) has initiated an exciting and unique project to dispose of its inventory of uranium-233 (233U) stored at Oak Ridge National Laboratory (ORNL), and extract isotopes that show great promise in the treatment of deadly cancers. In addition to increasing the supply of potentially useful medical isotopes, the project will rid DOE of a nuclear concern and cut surveillance and security costs. For more than 30 years, DOE's ORNL has stored over 1,200 containers of fissile 233U, originally produced for several defense-related projects, including a pilot study that looked at using 233U as a commercial reactor fuel. This uranium, designated as special nuclear material, requires expensive security, safety, and environmental controls. It has been stored at an ORNL facility, Building 3019A, that dates back to the Manhattan Project. Down-blending the material to a safer form, rather than continuing to store it, will eliminate a $15 million a year financial liability for the DOE and increase the supply of medical isotopes by 5,700 percent. During the down-blending process, thorium-229 (229Th) will be extracted. The thorium will then be used to extract actinium-225 (225Ac), which will ultimately supply its progeny, bismuth-213 (213Bi), for on-going cancer research. The research includes Phase II clinical trials for the treatment of acute myelogenous leukemia at Sloan-Kettering Memorial Cancer Center in New York, as well as other serious cancers of the lungs, pancreas, and kidneys using a technique known as alpha-particle radioimmunotherapy. Alpha-particle radioimmunotherapy is based on the emission of alpha particles by radionuclides. 213Bi is attached to a monoclonal antibody that targets specific cells. The bismuth then delivers a high-powered but short-range radiation dose, effectively killing the cancerous cells but sparing the surrounding tissue. Production of the actinium and

  9. TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

    Nicholas, R.G.; Lacy, N.H.; Butz, T.R.; Brandon, N.E.

    2004-10-06

    As part of its commitment to clean up Cold War legacy sites, the U.S. Department of Energy (DOE) has initiated an exciting and unique project to dispose of its inventory of uranium-233 (233U) stored at Oak Ridge National Laboratory (ORNL), and extract isotopes that show great promise in the treatment of deadly cancers. In addition to increasing the supply of potentially useful medical isotopes, the project will rid DOE of a nuclear concern and cut surveillance and security costs. For more than 30 years, DOE's ORNL has stored over 1,200 containers of fissile 233U, originally produced for several defense-related projects, including a pilot study that looked at using 233U as a commercial reactor fuel. This uranium, designated as special nuclear material, requires expensive security, safety, and environmental controls. It has been stored at an ORNL facility, Building 3019A, that dates back to the Manhattan Project. Down-blending the material to a safer form, rather than continuing to store it, will eliminate a $15 million a year financial liability for the DOE and increase the supply of medical isotopes by 5,700 percent. During the down-blending process, thorium-229 (229Th) will be extracted. The thorium will then be used to extract actinium-225 (225Ac), which will ultimately supply its progeny, bismuth-213 (213Bi), for on-going cancer research. The research includes Phase II clinical trials for the treatment of acute myelogenous leukemia at Sloan-Kettering Memorial Cancer Center in New York, as well as other serious cancers of the lungs, pancreas, and kidneys using a technique known as alpha-particle radioimmunotherapy. Alpha-particle radioimmunotherapy is based on the emission of alpha particles by radionuclides. 213Bi is attached to a monoclonal antibody that targets specific cells. The bismuth then delivers a high-powered but short-range radiation dose, effectively killing the cancerous cells but sparing the surrounding tissue. Production of the actinium and

  10. Identification of groundwater discharge in Cuddalore Coast, Tamil Nadu using radium isotopes

    For the optimal exploitation and management of coastal aquifers of Tamil Nadu, it is essential to evaluate the groundwater outflow into the sea. In this study, radium isotopes (223,224Ra) were employed to understand the groundwater discharge in coastal areas of Cuddalore district, Tamil Nadu. Sea water samples (100 L) were collected from various locations of Cuddalore coast in October 2011 and passed through Mn-impregnated acrylic fiber columns. These acrylic columns were analyzed for 223,224Ra activities using Radium Delayed Coincidence Counter (RaDeCC). The observed higher activities of 223,224Ra (0-0.18 and 3.84-22.77 dpm/L respectively) indicate that groundwater discharge occurs in this coastal region. (author)

  11. Identification of groundwater discharge in Cuddalore coast, Tamil Nadu using radium isotopes

    For the optimal exploitation and management of coastal aquifers of Tamil Nadu, it is essential to evaluate the groundwater outflow into the sea also called as submarine groundwater discharge. In this study, radium isotopes (223,224Ra) were employed to understand the groundwater discharge in coastal areas of Cuddalore district, Tamil Nadu. Sea water samples (100 L) were collected from various locations of Cuddalore coast in October 2011 and passed through Mn-impregnated acrylic fiber columns. These acrylic columns were analyzed for 223,224Ra activities using radium delayed coincidence counter. The observed higher activities of 223,224Ra excess (0.02 ± 0.001-3.28 ± 0.16 and 64 ± 3-380 ± 19 mBq/100 L respectively) indicate that groundwater discharge occurs in this coastal region. (author)

  12. An alternative transformation in ranking using l_1 -norm in data envelopment analysis

    Ziari, S.

    2016-05-01

    Jahanshahloo et al. (Appl Math Comput 153:215-224, 2004) propose a method for ranking extremely efficient decision making units (DMUs) in data envelopment analysis (DEA) using super-efficiency technique and l1-norm and they show that the presented method is able to eliminate the existing difficulties in some methods. This paper suggests an alternative transformation to convert the nonlinear model proposed by Jahanshahloo et al. (Appl Math Comput 153:215-224, 2004) into a linear programming form. The present paper shows that model with this transformation is equivalent to the above-mentioned nonlinear model. The motivation of this work is to linearize the proposed nonlinear model by Jahanshahloo et al. (Appl Math Comput 153:215-224, 2004) which has the higher order of complexity.

  13. Sequential phosphorylation of GRASP65 during mitotic Golgi disassembly

    Danming Tang

    2012-09-01

    GRASP65 phosphorylation during mitosis and dephosphorylation after mitosis are required for Golgi disassembly and reassembly during the cell cycle. At least eight phosphorylation sites on GRASP65 have been identified, but whether they are modified in a coordinated fashion during mitosis is so far unknown. In this study, we raised phospho-specific antibodies that recognize phosphorylated T220/T224, S277 and S376 residues of GRASP65, respectively. Biochemical analysis showed that cdc2 phosphorylates all three sites, while plk1 enhances the phosphorylation. Microscopic studies using these antibodies for double and triple labeling demonstrate sequential phosphorylation and dephosphorylation during the cell cycle. S277 and S376 are phosphorylated from late G2 phase through metaphase until telophase when the new Golgi is reassembled. T220/224 is not modified until prophase, but is highly modified from prometaphase to anaphase. In metaphase, phospho-T220/224 signal localizes on both Golgi haze and mitotic Golgi clusters that represent dispersed Golgi vesicles and Golgi remnants, respectively, while phospho-S277 and S376 labeling is more concentrated on mitotic Golgi clusters. Expression of a phosphorylation-resistant GRASP65 mutant T220A/T224A inhibited mitotic Golgi fragmentation to a much larger extent than the expression of the S277A and S376A mutants. In cytokinesis, T220/224 dephosphorylation occurs prior to that of S277, but after S376. This study provides evidence that GRASP65 is sequentially phosphorylated and dephosphorylated during mitosis at different sites to orchestrate Golgi disassembly and reassembly during cell division, with phosphorylation of the T220/224 site being most critical in the process.

  14. 利用STEP/XML的CAD/CAPP信息交换与共享模型及实现%The model of information exchange and sharing for CAD/CAPP using STEP and XML schema

    陈守强; 蔡长韬

    2011-01-01

    针对异构系统之间难以解决的产品数据交换与共享问题,深入研究了制造信息资源共享、STEP AP203/AP214文件到AP224文件的转换规则等关键技术.采用STEP标准作为CAD系统的信息输出,提出了通过STEP中性文件转换器把CAD系统输出AP203/AP214文件转换成AP224文件,CAPP系统通过AP224中性文件来获取零件的几何和工艺信息的方法.利用STEP AP28所制定的转换规则,将STEP文件转换为相应的XML中性文件,建立XML schema库,以实现制造信息的数据交换和共享.%To solve the problem of product data exchange and sharing among heterogeneous systems, the key technologies, including manufacturing information sharing, file conversion from STEP AP203/AP214 to AP224 with the conversion ware of STEP neutral files, are discussed. Using STEP standard as information output of CAD systems, the AP203/AP214 file output from CAD systems is transformed to AP224 file with STEP neutral file, while CAPP systems obtained geometry and manufacturing process information of the parts with AP224 neutral files. By translating the STEP files into corresponding XML neutral files according to the transformation criterions constituted by STEP AP28, XML schema library is setup. Upon this, product data exchange and sharing of manufacturing information can be achieved.

  15. Alternating-parity collective states of yrast and nonyrast bands in lanthanide and actinide nuclei

    Nadirbekov, M. S., E-mail: nodirbekov@inp.uz; Yuldasheva, G. A. [Uzbek Academy of Sciences, Institute of Nuclear Physics (Uzbekistan); Denisov, V. Yu. [National Academy of Sciences of Ukraine, Institute for Nuclear Research (Ukraine)

    2015-03-15

    Excited collective states of even-even nuclei featuring quadrupole and octupole deformations are studied within a nonadiabatic collective model with a Gaussian potential energy. Rotational states of the yrast band and vibrational-rotational states of nonyrast bands are considered in detail. The energies of alternating-parity excited states of the yrast band in the {sup 164}Er, {sup 220}Ra, and {sup 224}Th nuclei; the yrast and first nonyrast bands in the {sup 154}Sm and {sup 160}Gd nuclei; and the yrast, first nonyrast, and second nonyrast bands in the {sup 224}Ra and {sup 240}Pu nuclei are described well on the basis of the proposed model.

  16. Alternating-parity collective states of yrast and nonyrast bands in lanthanide and actinide nuclei

    Excited collective states of even-even nuclei featuring quadrupole and octupole deformations are studied within a nonadiabatic collective model with a Gaussian potential energy. Rotational states of the yrast band and vibrational-rotational states of nonyrast bands are considered in detail. The energies of alternating-parity excited states of the yrast band in the 164Er, 220Ra, and 224Th nuclei; the yrast and first nonyrast bands in the 154Sm and 160Gd nuclei; and the yrast, first nonyrast, and second nonyrast bands in the 224Ra and 240Pu nuclei are described well on the basis of the proposed model

  17. Well-defined 2:1 and 2:2 arylcopper-copper bromide aggregates and selective biaryl formation

    Koten, G. van; Janssen, M.D.; Corsten, M.A.; Spek, A.L.; Grove, D.M.

    1996-01-01

    Reaction of tetranuclear [Li4(C6H4CH2NMe2-2)4] (1) with 4/3 equiv of the copper(I) arenethiolate [Cu3(SC6H4NMe2-2)3] (2) results in the quantitative formation of the arylcopper compound [Cu4(C6H4CH2NMe2-2)4] (3) and the lithium arenethiolate [Li(SC6H4NMe2-2)]n (4). The arylcopper species 3 is a yell

  18. EST Table: FS909077 [KAIKOcDNA[Archive

    Full Text Available FS909077 E_FL_fufe_16C10_F_0 10/09/28 45 %/224 aa ref|XP_975194.1| PREDICTED: similar to something...l|GB19080-PA 10/09/10 45 %/224 aa gi|91081571|ref|XP_975194.1| PREDICTED: similar to something about silencing protein 10 [Tribolium castaneum] FS937283 fufe ... ... about silencing protein 10 [Tribolium castaneum] gb|EFA01562.1| hypothetical protein TcasGA2...55 aa AGAP002960-PA Protein|2R:30130647:30132122:-1|gene:AGAP002960 10/09/10 39 %/236 aa gnl|Ame

  19. The Incidence of Helminth Parasites in Donkeys

    G.B. Shrikhande

    2009-12-01

    Full Text Available The faeces of 82 donkeys irrespective of sex and age were collected and examined for any parasitic ova. The faecal sample of68 donkeys were infected with: Strongylus sp. (54.87%, Parascaris sp. (29.26%, Strongyloides sp. (24.39%, Trichonema sp. (15.85%,Oxyuris sp. (8.53%, Gastrodiscus sp. (8.53%, Entamoeba sp. (8.53%, Dictyocaulus sp. (3.65%, and Triodontophorus sp. (2.43%. [Vet World 2009; 2(6.000: 224-224

  20. Microstrip antenna for polarimetric C-band SAR

    Granholm, Johan; Woelders, Kim; Dich, Mikael;

    1994-01-01

    The paper outlines the design and the measured performance of a 224-element dual-linearly polarized microstrip array antenna with low cross-polarization. The array is currently being flown on the Danish high-resolution polarimetric C-band synthetic aperture radar (SAR)......The paper outlines the design and the measured performance of a 224-element dual-linearly polarized microstrip array antenna with low cross-polarization. The array is currently being flown on the Danish high-resolution polarimetric C-band synthetic aperture radar (SAR)...

  1. AcEST: DK952621 [AcEST

    Full Text Available TST38A01NGRL0014_J13 630 Adiantum capillus-veneris mRNA. clone: TST38A01NGRL0014_J13. 5' end seq ... ferase, chloroplastic OS=Arabidopsis thaliana GN=G-TMT ... PE=2 SV=2 Length = 348 Score = 217 bits (552), Exp ... opherol methyltransferase OS=Gossypium hirsutum GN=TMT ... PE=2 SV=1 Length = 344 Score = 235 bits (600), Exp ... copherol methyltransferase OS=Brassica oleracea GN=TMT ... PE=2 SV=1 Length = 347 Score = 224 bits (571), Exp ... -tocopherol methyltransferase OS=Brassica napus GN=TMT ... PE=2 SV=1 Length = 347 Score = 224 bits (571), Exp ...

  2. Computed tomography studies of human brain movements

    Rhythmic brain movements have been revealed by sets of sequential computed tomography scans of human brains (seen retrospectively to be normal). These scans have shown that both (unenhanced) brain parenchymal density and the shapes of the elements of the supratentorial ventricular/cisternal system are subject to wave motions having similar periods - ranging from 26 s through 56 s, 77-96 s, 109 s and 224 s to 224 X 2 s (or even longer), with good correlation between peak values. These motions, as well as phase variations between the waves, suggest a peristaltic movement of cerebrospinal fluid through the ventricular/cisternal system with progressive axial damping

  3. Slow rhythmic ventricular oscillations and parenchymal density variations shown by sequential CT scanning

    Rhythmic brain movements have been revealed by sets of sequential computerised tomography scans of human brains (seen retrospectively to be normal). These scans have shown that both (unenhanced) brain parenchymal density and the shapes of the elements of the supratentorial ventricular/cisternal system are subject to wave motions having similar periods-ranging from 26 s through 56 s, 77-96 s, 109 s, and 224 s to 224 x 2 s (or even longer), with good correlation between peak values. These motions, as well as phase variations between the waves suggest a peristaltic movement of CSF through the ventricular/cisternal system with progressive axial damping

  4. Dicty_cDB: Contig-U06999-1 [Dicty_cDB

    Full Text Available complete... 43 0.004 CP001228_13( CP001228 |pid:none) Rickettsia peacockii str. Rustic ... 43 0.005 CP001099...idium botulinum A2 str. K... 37 0.29 CP000061_17( CP000061 |pid:none) Aster yellows witches'-broom phyt... 3...ca 224 ||||||||||||||||||| Sbjct: 206 caggaattccaattaacca 224 Score = 63.9 bits (32), Expect = 2e-10 Identities...2 effective length of database: 5,564,391 effective search space: 2793324282 effective search spac...|||||||||||||||||||||||||| Sbjct: 178 gatagctatattatagaagtagaaataccagg 209 Score = 50.1 bits (25), Expect(4) = 3e-85 Identities

  5. DISSOLVED CONCENTRATION LIMITS OF RADIOACTIVE ELEMENTS

    NA

    2004-11-22

    The purpose of this study is to evaluate dissolved concentration limits (also referred to as solubility limits) of elements with radioactive isotopes under probable repository conditions, based on geochemical modeling calculations using geochemical modeling tools, thermodynamic databases, field measurements, and laboratory experiments. The scope of this modeling activity is to predict dissolved concentrations or solubility limits for 14 elements with radioactive isotopes (actinium, americium, carbon, cesium, iodine, lead, neptunium, plutonium, protactinium, radium, strontium, technetium, thorium, and uranium) important to calculated dose. Model outputs for uranium, plutonium, neptunium, thorium, americium, and protactinium are in the form of tabulated functions with pH and log (line integral) CO{sub 2} as independent variables, plus one or more uncertainty terms. The solubility limits for the remaining elements are either in the form of distributions or single values. The output data from this report are fundamental inputs for Total System Performance Assessment for the License Application (TSPA-LA) to determine the estimated release of these elements from waste packages and the engineered barrier system. Consistent modeling approaches and environmental conditions were used to develop solubility models for all of the actinides. These models cover broad ranges of environmental conditions so that they are applicable to both waste packages and the invert. Uncertainties from thermodynamic data, water chemistry, temperature variation, and activity coefficients have been quantified or otherwise addressed.

  6. Formerly utilized MED/AEC sites remedial action program. Radiological survey of the E. I. Du Pont de Nemours and Co. , Deepwater, New Jersey. Final report

    None

    1978-12-01

    The results of a radiological survey of the E. I. Du Pont Company, Deepwater, New Jersey, are presented in this report. During the 1940's this site was used for development of a process for the conversion of uranium oxide to produce uranium tetrafluoride and small quantities of uranium metal. The survey included measurements of the following: residual alpha and beta--gamma contamination levels, both fixed and transferable, in the one remaining uranium tetrafluoride operations building; external gamma radiation levels at 1 m above the surface inside this building and at outdoor locations where radioactive materials were handled; radon and radon daughter concentrations in the air in the operations building; uranium, radium, actinium, and thorium concentrations in soil and water on and near the site; and the airborne concentrations of uranium, thorium, and radium in the operations building. Elevated concentrations of uranium were found in residues from the operations building and in some surface and subsurface soil samples. Alpha and beta--gamma contamination levels in some areas of the operations building were above the limits of current federal guidelines set for the release of property for unrestricted use. 18 figures, 11 tables.

  7. Geological disposal: security and R and D. Security of 'second draft for R and D of geological disposal'

    The second draft for R and D of geological disposal (second draft) was arranged in 1999. The idea of security of geological disposal in the second draft is explained. The evaluation results of the uncertainty analysis and an example of evaluation of the effect of separation nuclear transmutation on the geological disposal are shown. The construction of strong engineered barrier is a basic idea of geological disposal system. Three processes such as isolation, engineering countermeasures and safety evaluation are carried out for the security of geological disposal. The security of geological environment for a long time of 12 sites in Japan was studied by data. Provability of production and enforcement of engineered barrier were confirmed by trial of over pack, tests and the present and future technologies developed. By using the conditions of reference case in the second draft, the evaluation results of dose effects in the two cases: 1) 90 to 99% Cs and Sr removed from HLW (High Level radioactive Waste) and 2) high stripping ratio of actinium series are explained. (S.Y.)

  8. Selective Decontamination Effect of Metal Ions in Soil Using Supercritical CO{sub 2} and TBP Complex

    Park, Jihye; Park, Kwangheon; Jung, Wonyoung [Kyunghee Univ., Yongin (Korea, Republic of)

    2014-10-15

    Decontamination of soil pollution is difficult because the type of contamination largely depends on the characteristics of the pollutant and the area. Also, existing soil decontamination methods generate large quantities of secondary waste and additional process costs. For this reason, new decontamination methods are always under active investigation. A method involving the use of supercritical carbon dioxide with excellent permeability in place of chemical solvents is currently being studied. Unlike other heavy metals in fission products, uranium is used as fuel, and must be handled carefully. Therefore, in this paper, we studied a supercritical carbon dioxide method for decontaminating heavy metal ions in soil using tri-n-butyl phosphate(TBP), which is well known as a ligand for the extraction of metal ions of actinium. We investigated the decontamination effect of heavy metal ions in the soil using TBP-HNO{sub 3} Complex and supercritical carbon dioxide. The study results showed that when heavy metals in soil are extracted using supercritical carbon dioxide, the extraction efficiency is different according to the type of pollutant metal ions in the soil. When TBP-HNO{sub 3} Complex is used with an extractant, uranium extraction is very effective, but lithium, strontium, and cesium extraction is not effective. Therefore, in the case of a mixture of uranium and other metals such as lithium, strontium, cesium, and so on in soil contaminated by fission product leaks from nuclear power plants, we can selectively decontaminate uranium with supercritical carbon dioxide and TBP-HNO{sub 3} Complex.

  9. Tumor immunotargeting using innovative radionuclides.

    Kraeber-Bodéré, Françoise; Rousseau, Caroline; Bodet-Milin, Caroline; Mathieu, Cédric; Guérard, François; Frampas, Eric; Carlier, Thomas; Chouin, Nicolas; Haddad, Ferid; Chatal, Jean-François; Faivre-Chauvet, Alain; Chérel, Michel; Barbet, Jacques

    2015-01-01

    This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality. PMID:25679452

  10. Tumor Immunotargeting Using Innovative Radionuclides

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  11. Purification of lanthanides for double beta decay experiments

    Polischuk, O. G.; Barabash, A. S.; Belli, P.; Bernabei, R.; Boiko, R. S.; Cappella, F.; Cerulli, R.; Danevich, F. A.; Incicchitti, A.; Laubenstein, M.; Mokina, V. M.; Nisi, S.; Poda, D. V.; Tretyak, V. I.

    2013-08-01

    There are several potentially double beta active isotopes among the lanthanide elements. However, even high purity grade lanthanide compounds contain 238U, 226Ra and 232,228Th typically on the level of ˜ (0.1 - 1) Bq/kg. The liquid-liquid extraction technique was used to remove traces of U, Ra and Th from CeO2, Nd2O3 and Gd2O3. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe γ spectrometry at the underground Gran Sasso National Laboratories of the INFN (Italy). After the purification the radioactive contamination of gadolinium oxide by Ra and Th was decreased at least one order of magnitude. The efficiency of the approach to purify cerium oxide from Ra was on same level, while the radioactive contamination of neodymium sample before and after the purification is below the sensitivity of analytical methods. The purification method is much less efficient for chemically very similar radioactive elements like lanthanum, lutetium and actinium. R&D of the methods to remove the pollutions with improved efficiency is in progress.

  12. Radionuclides in coastal swampland soils in South Australia - An unusual distribution?

    A plant processing uranium ore was constructed during the 1950's on coastal swamplands at Port Pirie, South Australia, with tailings and chemical residues stored in clay-lined dams on site. Environmental soil samples collected recently from this area showed an unusual radionuclide distribution which suggested possible contamination from the former uranium plant nearby. On subsequent investigation it appears this distribution is a general property of swampland soils. The concentration of uranium in these soils is significantly greater (2-10 times) than that of its decay products, with an observed range of uranium concentrations from 50 to 300 Bq/kg. In contrast, 'normal' soils in South Australia contain between 5 and 60 Bq/kg, with decay products close to secular equilibrium. In addition, actinium (and its parent, protactinium) occur in sediments in greater concentration than expected - 6 to 36 Bq/kg compared with a 'normal soil' range of 0.2 to 3 Bq/kg. Results obtained suggest: organic residues in the sediments play a major part in the concentration of radionuclides; and the probable source of radionuclides is sea-water. These observations are consistent with results of other workers who examined the incorporation of stable trace metals into coastal swampland sediments in South Australia. Representative data are presented and discussed

  13. Study of Thorium Utilization in a Large Scale Sodium Cooled Fast Reactor

    The breeding performance of 232Th in fast reactor is better than 238U, since the capture cross section of 232Th is slightly higher than 238U under the fast neutron spectrum. There are much less fission neutrons in the blanket, so the proportion of neutron with energy above 6MeV (the threshold energy of (n,2n) reaction of 232Th) is very small. Therefore, the 233U produced in fast reactor blanket would have high purity. In this paper, an large scale fast reactor core was taken as the reference core for 232Th utilization study. In the calculation results, the whole capability of 233U production is about 443kg/(GWe•a) in the blanket; at the end of the first cycle (160EFPD), the 233U production per unit mass of 232Th is about 10.71g/(kgTh), and the weight fraction of 232U in actinium is less than 0.019%. It is an attractive technology option to produce 233U in the blanket. (author)

  14. Background radiation and individual dosimetry in the coastal area of Tamil Nadu (India)

    South coast of India is known as the high-level background radiation area (HBRA) mainly due to beach sands that contain natural radionuclides as components of the mineral monazite. The rich deposit of monazite is unevenly distributed along the coastal belt of Tamil Nadu and Kerala. An HBRA site that laid in 2x7 m along the sea was found in the beach of Chinnavillai, Tamil Nadu, where the maximum ambient dose equivalent reached as high as 162.7 mSv y-1. From the sands collected at the HBRA spot, the high-purity germanium semi-conductor detector identified six nuclides of thorium series, four nuclides of uranium series and two nuclides belonging to actinium series. The highest radioactivity observed was 43.7 Bq g-1 of Th-228. The individual dose of five inhabitants in Chinnavillai, as measured by the radiophotoluminescence glass dosimetry system, demonstrated the average dose of 7.17 mSv y-1 ranging from 2.79 to 14.17 mSv y-1. (authors)

  15. Emanations and 'induced' radioactivity: from mystery to (mis)use

    The natural Rn isotopes were discovered within the period 1899-1902 and at that time referred to as emanations because they came out (emanated) of sources/materials containing actinium, thorium and radium, respectively. The (somewhat mysterious) emanations appeared to disintegrate into radioactive decay products which by depositing at solid surfaces gave rise to 'induced' radioactivity i.e. radioactive substances with various half-lives. Following the discovery of the emanations the volume of the research involving them and their disintegration products grew steeply. The identity of a number of these radioactive products was soon established. Radium emanation was soon used as a source of RaD (210Pb) to be applied as an 'indicator' (radiotracer) for lead in a study on the solubility of lead sulphide and lead chromate. Moreover, radium and its emanation were introduced into the medical practice. Inhaling radon and drinking radon-containing water became an accepted medicinal use (or misuse?) of that gas. Shortly after the turn of the century, the healing (?) action of natural springs (spas) was attributed to their radium emanation, i.e. radon. Bathing in radioactive spring water and drinking it became very popular. Even today, bathing in radon-containing water is still a common medical treatment in Jachymov, Czech Republic. (author)

  16. Liquid Scintillation Counting of Environmental Radioisotopes: A Review of the Impact of Background Reduction

    Douglas, Matthew; Bernacki, Bruce E.; Erchinger, Jennifer L.; Finn, Erin C.; Fuller, Erin S.; Hoppe, Eric W.; Keillor, Martin E.; Morley, Shannon M.; Mullen, Crystal A.; Orrell, John L.; Panisko, Mark E.; Warren, Glen A.; Wright, Michael E.

    2016-03-09

    Liquid scintillation counting (LSC) is a versatile and commonplace method for radiometric measurement of charged particle emitting radionuclides. The LSC method provides utility in a range of environmental science applications including hydrological studies of water transport, anthropogenic releases of radionuclides into the environment, and vertical mixing rates within oceans. Instrumental measurement background is one limiting factor of radiometric measurement sensitivity. As part of the development of a custom low background LSC system located in a shallow underground laboratory at Pacific Northwest National Laboratory, a number of measurement applications of LSC have been considered and are summarized here. The focus is on determining which aspects of such measurements would gain the greatest benefit from the reduction of LSC backgrounds by a factor of 10-100 relative to values reported in the literature. Examples of benefits include lowering the minimum detectable activity, reducing the sample size required, and shortening the elapsed timeline of the processing and analysis sequence. In particular tritium, strontium, and actinium isotopes are examined as these isotopes cover a range of requirements related to the LSC measurement method (e.g., 3H: low energy; Sr: spectral deconvolution; Ac: alpha/beta discrimination).

  17. Development of an Ultra-Low Background Liquid Scintillation Counter for Trace Level Analysis

    Erchinger, Jennifer L.; Orrell, John L.; Aalseth, Craig E.; Bernacki, Bruce E.; Douglas, Matthew; Finn, Erin C.; Fuller, Erin S.; Keillor, Martin E.; Morley, Shannon M.; Mullen, Crystal A.; Panisko, Mark E.; Shaff, Sarah M.; Warren, Glen A.; Wright, Michael E.

    2015-09-01

    Low-level liquid scintillation counting (LSC) has been established as one of the radiation detection techniques useful in elucidating environmental processes and environmental monitoring around nuclear facilities. The Ultra-Low Background Liquid Scintillation Counter (ULB-LSC) under construction in the Shallow Underground Laboratory at Pacific Northwest National Laboratory aims to further reduce the MDAs and/or required sample processing. Through layers of passive shielding in conjunction with an active veto and 30 meters water equivalent overburden, the background reduction is expected to be 10 to 100 times below typical analytic low-background liquid scintillation systems. Simulations have shown an expected background of around 14 counts per day. A novel approach to the light collection will use a coated hollow light guide cut into the inner copper shielding. Demonstration LSC measurements will show low-energy detection, spectral deconvolution, and alpha/beta discrimination capabilities, from trials with standards of tritium, strontium-90, and actinium-227, respectively. An overview of the system design and expected demonstration measurements will emphasize the potential applications of the ULB-LSC in environmental monitoring for treaty verification, reach-back sample analysis, and facility inspections.

  18. Enhanced radioactivity due to natural oil and gas production and related radiological problems

    Within the scope of a research contract, the following aspects are considered: External radiation exposure at production sites; internal radiation exposures during cleaning operations such as removing of scale by sand blasting; problems of waste disposal; internal radiation exposure due to radon inhalation by consumers; the origin of the high radium content of brines from oil and gas fields. Enhanced dose rates up to 50 μSv/h have been found at the external surface of saltwater tanks, but 72% of the 160 sites investigated did not show any increase above the natural background. Brines from gas contained radium-226 up to 286 Bq/1 and scale up to 1 kBq/g. In brines and scale from oil fields radium-228 was usually the dominating radionuclide. Some samples contained significant amounts of lead-210 and even actinium-227, too, but practically no uranium or thorium. The radon-222 concentrations in natural gas samples varied between 0.004 and 4 Bq/l with an average value of 0.6 Bq/l. Related radiological problems are discussed. (orig./HP)

  19. Neutron measurements with miniature fission chambers

    This report analyses the use and qualification of miniature fission chambers for two types of neutron measurements: 1) relative measurements in nuclear power reactors, or nuclear irradiation reactors. We consider the problem of burnable fissile material in detectors, under important neutron exposures and conclude on recommending the use of regenerating neutron detectors. 2) Measurements of integral physical parameters in experimental reactors. This method has been applied to measurements of fission rates in detectors with strong alpha-rays emitter deposits in order to establish standard tables of physical parameters. It has been used in particular for detectors including very radioactive actinium series. After a discussion of the instrumentation choice and data processing, specific to each measurements, we provide results on: 1) the technological and neutron behaviour of regenerating miniature fission chambers, in the swimming pool reactor 'TRITON', under a neutron exposure of 7.1020 n cm-2 and a gamma-rays exposure of 1,5.1011 rads about. The fissile material is 235U and the fertile material 234U. 2) The integral measurements of effective cross sections for 241Am and 238Pu in the experimental reactor 'MINERVE' use for study of problems of fast neutron reactors

  20. Quantification of radionuclide transfer in terrestrial and freshwater environments: A summary

    Exposure may occur as a result of incidental releases and discharges from all stages of the nuclear fuel cycle. This includes uranium mines, fuel fabrication facilities, reactors, reprocessing plants and low, intermediate and high level radioactive waste repository sites. Each of these releases involves mainly fission and neutron activation products as well as actinides. Uranium mining and fuel fabrication also involve radionuclides of the uranium, actinium and thorium decay series. In addition, some industries such as mineral sands production and processing, phosphate ore processing, coal burning and oil and gas production can generate naturally occurring radioactive materials (NORMs) as waste. Other sources of human exposure include nuclear weapon testing and radiation accidents or incidents. Any radiological assessments are based on an analysis of radionuclide transport patterns and processes governing radionuclide behaviour in the environment. Therefore, it is an aim of the IAEA to support Member States to enhance their capability for evaluating radionuclide transport, geochemical and biochemical enrichment, and radiation effects on human beings and other biota

  1. Study of Soil Decontamination Method Using Supercritical Carbon Dioxide and TBP

    The result of this study means that we have a possible new method for cheap and less wasteful nuclear waste decontamination. When severe accidents such as the incident at the Fukushima nuclear site occur, the soil near the power plant is contaminated with fission products or the activation metal structure of the power plant. The soil pollution form depends on the environment and soil characteristics of the contaminated areas. Thus, a- single-decontamination method is not effective for site cleanup. In addition, some soil decontamination methods are expensive and large amounts of secondary waste are generated. Therefore, we need new soil decontamination methods. In this study, instead of using a conventional solvent method that generates secondary waste, supercritical carbon dioxide was used to remove metal ions from the soil. Supercritical carbon dioxide is known for good permeation characteristics. We expect that we will reduce the cost of soil pollution management. Supercritical carbon dioxide can decontaminate soil easily, as it has the ability to penetrate even narrow gaps with very good moisture permeability. We used TBP, which is a known for extractant of actinium metal. TBP is usually used for uranium and strontium extraction. Using TBP-HNO3 complex and supercritical carbon dioxide, we did extraction experiments for several heavy metals in contaminated soil

  2. Selective Decontamination Effect of Metal Ions in Soil Using Supercritical CO2 and TBP Complex

    Decontamination of soil pollution is difficult because the type of contamination largely depends on the characteristics of the pollutant and the area. Also, existing soil decontamination methods generate large quantities of secondary waste and additional process costs. For this reason, new decontamination methods are always under active investigation. A method involving the use of supercritical carbon dioxide with excellent permeability in place of chemical solvents is currently being studied. Unlike other heavy metals in fission products, uranium is used as fuel, and must be handled carefully. Therefore, in this paper, we studied a supercritical carbon dioxide method for decontaminating heavy metal ions in soil using tri-n-butyl phosphate(TBP), which is well known as a ligand for the extraction of metal ions of actinium. We investigated the decontamination effect of heavy metal ions in the soil using TBP-HNO3 Complex and supercritical carbon dioxide. The study results showed that when heavy metals in soil are extracted using supercritical carbon dioxide, the extraction efficiency is different according to the type of pollutant metal ions in the soil. When TBP-HNO3 Complex is used with an extractant, uranium extraction is very effective, but lithium, strontium, and cesium extraction is not effective. Therefore, in the case of a mixture of uranium and other metals such as lithium, strontium, cesium, and so on in soil contaminated by fission product leaks from nuclear power plants, we can selectively decontaminate uranium with supercritical carbon dioxide and TBP-HNO3 Complex

  3. Exposure to radioactive aerosols in mining and milling operations: the importance of 227Ac and 231Pa

    'Full-Text:' 227Ac (half-life of 21.8 y) is the daughter or 231Pa; a beta emitter and parent of a subseries with five short-lived alpha-emitters. 231Pa (half-life of 3.27x104 y) is an alpha-emitter of the actinium series, the decay chain of 235U. As daughters of this uranium isotope they are thought to be unimportant as a radiological hazard, despite the fact that their ALI values for ingestion and inhalation are the lowest of any other radionuclide. Both nuclides can be considered as being in secular equilibrium with uranium in most geological media and so the mass concentration of 231Pa is the same of the 226Ra and that of 227Ac is the same of the 210Pa, to mention only two radionuclides of radiological concern. It is shown in this paper that if 231Pa and 227Ac are considered in the evaluations of dose commitments incurred by inhalation of aerosols in mining and milling operations, the results can be 70% higher than those calculated by the methodology of ICRP Publication 47. (author)

  4. Soil and river sediments radionuclides monitoring at Aramar Experimental Center: an historical overview

    In order to evaluate possible effects to the environment resulting from the implementation of the Centro Tecnologico da Marinha - Centro Experimental Aramar (CTMSP-CEA) at Ipero in Sao Paulo state, Brazil, which came into operation in 1989, an Environmental Monitoring Program (PMA) was established in October, 1987. One of the aims of this program is to monitor the soil and river sediments radionuclides levels at CEA and beyond its boundary. The utilization of statistical tools to evaluate the results of radiometric environmental monitoring is a procedure required by National Nuclear Energy Commission (CNEN). The box plot is a simple statistical tool for displaying data. The central tendency and dispersion of the results as well as the observation of unusual results (outliers) in the dataset are easily visualized. Control chart is a graph that maps data and provides a picture of how a process is performing over time. A control chart always has a central line for the mean, an upper line for the upper control limit and a lower line for the lower control limit. Box plots and control charts were used to visualize the annual amount of natural uranium, lead-214, actinium-228 and lead-212 in soil and river sediment detected between 1987 and 2011, considering the measurements of all monitored places each year. This historical observation shows that, in average, the results obtained are below than the 1987-1988 levels (CEA's pre-operational) or below than the backgrounds radionuclides values. (author)

  5. Theoretical Study on Properties of New Isotope 265Bh

    The properties of nuclei belonging to the newly observed α-decay chain starting from 265Bh have been studied. The axially deformed relativistic mean-field calculation with the force NL-Z2 has been performed in the blocked BCS approximation. Some ground state properties such as binding energies, deformations, spins, and parities, as well as Q-values of the α-decay for this decay chain have been calculated and compared with known experimental data. Good agreement is found. The single-particle spectrum of the nucleus 265Bh is studied and some new magic numbers are found, while the magnitudes of the shell gaps in superheavy nuclei are much smaller than those of nuclei before the actinium region, and the Fermi surfaces are close to the continuum. Thus the superheavy nuclei are usually not stable. The α-decay lifetimes in the 265Bh decay chain are evaluated by different formulae, and compared with experimental data. The methods which give good agreement with the data are selected.

  6. Workplace monitoring and related health hazard evaluation in South African mining and mineral processing industries by application of nuclear and related analytical techniques

    The South African Government notice R 849 (23 April 1994) requires application to the South African Council for Nuclear Safety (CNS) for a nuclear licence if materials are dealt with that contain more than 0,2 but less than 1 Becquerel per gram of any radionuclide of the natural uranium, thorium and actinium decay series. If the material is to be used in the construction of buildings the application should have been made before 1 April 1996, otherwise before 31 March 1999. The first phase of the monitoring programme assesses the observed radioactivity levels of waste products and the possible radiological impact on people working on site and living in the direct environment of the operational site. Information has been obtained on the radionuclide content and elemental composition of the various sources of the coal, waste ash, ash related products, crusher materials and effluent water. Except for the effluent and coal samples all other materials showed activity levels for one or more nuclides above the 0,2 Bq/g but not exceeding the 1 Bq/g level. Accordingly a first order assessment of the possible radiological impact on workers and the public has been performed for water consumption and dust inhalation. Actual dust concentrations recorded at various sites within the operational area are used to evaluate the yearly dose to workers. (author)

  7. Purification of lanthanides for double beta decay experiments

    Polischuk, O. G. [Institute for Nuclear Research, MSP 03680 Kyiv, Ukraine and INFN, Section of Rome, La Sapienza, I-00185 Rome (Italy); Barabash, A. S. [Institute of Theoretical and Experimental Physics, 117259 Moscow (Russian Federation); Belli, P. [INFN, Section of Rome Tor Vergata, I-00133 Rome (Italy); Bernabei, R. [INFN, Section of Rome Tor Vergata, I-00133 Rome, Italy and Department of Physics, University of Rome Tor Vergata, I-00133 Rome (Italy); Boiko, R. S.; Danevich, F. A.; Mokina, V. M.; Poda, D. V.; Tretyak, V. I. [Institute for Nuclear Research, MSP 03680 Kyiv (Ukraine); Cappella, F.; Incicchitti, A. [INFN, Section of Rome La Sapienza, I-00185 Rome, Italy and Department of Physics, University of Rome La Sapienza, I-00185 Rome (Italy); Cerulli, R.; Laubenstein, M.; Nisi, S. [INFN, Gran Sasso National Laboratories, I-67100 Assergi (Aq) (Italy)

    2013-08-08

    There are several potentially double beta active isotopes among the lanthanide elements. However, even high purity grade lanthanide compounds contain {sup 238}U, {sup 226}Ra and {sup 232,228}Th typically on the level of ∼ (0.1 - 1) Bq/kg. The liquid-liquid extraction technique was used to remove traces of U, Ra and Th from CeO{sub 2}, Nd{sub 2}O{sub 3} and Gd{sub 2}O{sub 3}. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe γ spectrometry at the underground Gran Sasso National Laboratories of the INFN (Italy). After the purification the radioactive contamination of gadolinium oxide by Ra and Th was decreased at least one order of magnitude. The efficiency of the approach to purify cerium oxide from Ra was on same level, while the radioactive contamination of neodymium sample before and after the purification is below the sensitivity of analytical methods. The purification method is much less efficient for chemically very similar radioactive elements like lanthanum, lutetium and actinium. R and D of the methods to remove the pollutions with improved efficiency is in progress.

  8. Fast Reed-Solomon Decoder

    Liu, K. Y.

    1986-01-01

    High-speed decoder intended for use with Reed-Solomon (RS) codes of long code length and high error-correcting capability. Design based on algorithm that includes high-radix Fermat transform procedure, which is most efficient for high speeds. RS code in question has code-word length of 256 symbols, of which 224 are information symbols and 32 are redundant.

  9. Layered double hydroxides as carriers of photoactive porphyrin molecules

    Lang, Kamil; Káfuňková, Eva; Kovanda, F.; Taviot-Guého, Ch.

    Bratislava : Institute of Inorganic Chemistry, Slovak Academy of Sciences, 2008. s. 246. ISBN 978-80-224-1019-9. [Conference on Solid State Chemistry /8./. 06.06.2008-11.06.2008, Bratislava] Institutional research plan: CEZ:AV0Z40320502 Keywords : photoactive porphyrin Subject RIV: CA - Inorganic Chemistry

  10. EVALUATION OF MIDAS™ FOR PRODUCTION OF ORNAMENTAL COCKSCOMB (Celosia argentea) IN FLORIDA

    A field trial was conducted to evaluate Midas™ (iodomethane:chloropicrin 50:50) for production of ornamental cockscomb (Celosia argentea var. cristata) in Martin County, Florida in spring 2006. Treatments included an untreated check, Midas™ applied at 224 kg/ha (200 lb/A), and methyl bromide:chloro...

  11. Transformation of the Czech Entrepreneurial Elite and the Conditions for Economic Development

    Benáček, Vladimír

    Praha: MATFYZPRESS, 2008 - (Mejstřík, M.), s. 197-224 ISBN 978-80-7378-074-6 R&D Projects: GA ČR GA403/08/1369 Institutional research plan: CEZ:AV0Z70280505 Keywords : Entrepreneurship * social capital * transition Subject RIV: AO - Sociology, Demography

  12. Differentiability of the metric projection onto a convex set with singular boundary points

    Šilhavý, Miroslav

    2015-01-01

    Roč. 22, č. 4 (2015), s. 969-997. ISSN 0944-6532 Institutional support: RVO:67985840 Keywords : metric projection * Fréchet derivative * normal cone Subject RIV: BA - General Mathematics Impact factor: 0.552, year: 2014 http://www.heldermann.de/JCA/JCA22/JCA224/jca22052.htm

  13. Kosmopolitizace společnosti a transkulturní obrat

    Kreuzzieger, Milan

    PrahaBratislava: Filosofia, 2014 - (Dinuš, P.; Hohoš, L.; Hrubec, M.), s. 236-247 ISBN 978-80-7007-413-8; ISBN 978-80-224-1371-8 Institutional support: RVO:67985955 Keywords : critical cosmopolitanism * cosmopolitization * cross-cultural turn * U. Beck Subject RIV: AA - Philosophy ; Religion

  14. Kukačka a kukaččí mládě v antických a středověkých odborných textech

    Šedinová, Hana

    Bratislava: Veda, 2015, s. 93-110. (Svet vedy. 35). ISBN 978-80-224-1423-4 R&D Projects: GA MŠk(CZ) LD13043 Institutional support: RVO:67985955 Keywords : Ancient ornithology * medieval ornithology * brood parasitism * Cuckoo * Cuckoo Young * Latin lexicography * Aristoteles * Aristoteles Latinus * Thomas of Cantimpré * Claretus Subject RIV: AI - Linguistics

  15. Measurement of nuclides of uranium and thorium series of disequilibrium using γ-spectroscopy

    刘广山; 黄奕普; 李静; 叶林

    2002-01-01

    The decay dynamic equations of two daughters were resolved as initial activities of daughters are not zero, and gave calculation formula of activities for measuring uranium and thorium series of disequilibrium using γ-spectroscopy. 238U, 234Th, 226Ra, 222Rn, 228Ra, 228Th, 224Ra, 212pb, 210pb and 40K in two sediment samples were determined as application.

  16. Unraveling environmental drivers of a recent increase in Swiss fungi fruiting

    Büntgen, Ulf; Peter, M.; Kauserud, H.; Egli, S.

    2013-01-01

    Roč. 19, č. 9 (2013), s. 2785-2794. ISSN 1354-1013 Institutional support: RVO:67179843 Keywords : climate change * forest ecology * fungi-host interaction * global carbon cycle * plant phenology * tree growth Subject RIV: EH - Ecology, Behaviour Impact factor: 8.224, year: 2013

  17. 30 let výzkumu šumavských jezer. Regenerace z okyselení a vliv gradace lýkožrouta

    Hruška, Jakub; Oulehle, Filip; Chuman, Tomáš; Kopáček, Jiří; Vrba, Jaroslav; Čtvrtlíková, Martina; Majer, V.

    2013-01-01

    Roč. 61, č. 5 (2013), s. 224-229. ISSN 0044-4812 R&D Projects: GA MŠk(CZ) ED1.1.00/02.0073; GA ČR(CZ) GAP504/12/1218 Institutional support: RVO:60077344 ; RVO:67179843 Keywords : acidification * water chemistry * biological recovery Subject RIV: DJ - Water Pollution ; Quality

  18. Protein (Cyanobacteria): 286011 [

    Full Text Available YP_007057271.1 1117:4890 1161:684 1185:224 373984:129 373994:129 histidine kinase,PAS ... domain-con ... taining protein,PAS ... domain-containing protein,histidine kinase,GAF dom ...

  19. Nástěnné malby v kostele sv. Jana Křtitele v Jindřichově Hradci do konce vlády Lucemburků

    Všetečková, Zuzana

    2009-01-01

    Roč. 57, č. 1 (2009), s. 2-24. ISSN 0049-5123 Institutional research plan: CEZ:AV0Z80330511 Keywords : wall paintings * Jindřichův Hradec * church of St John the Baptist Subject RIV: AL - Art, Architecture, Cultural Heritage

  20. Book review: Robert Leckey (ed. After Legal Equality: Family, Sex, Kinship

    Pawel Drągowski

    2015-12-01

    Full Text Available Book review: Robert Leckey (ed. After Legal Equality: Family, Sex, Kinship. Abingdon: Oxon; New York, NY: Routledge, 2015, pp. 224, ISBN 978-0-415-72161-5 £85DOWNLOAD THIS PAPER FROM SSRN: http://ssrn.com/abstract=2707055

  1. Further study on different dopings into PbWO.sub.4./sub. single crystals to increase the scintillation light yield

    Kobayashi, M.; Usuki, Y.; Ishii, M.; Itoh, M.; Nikl, Martin

    2005-01-01

    Roč. 540, - (2005), s. 381-394. ISSN 0168-9002 R&D Projects: GA AV ČR(CZ) KSK1010104 Institutional research plan: CEZ:AV0Z10100521 Keywords : lead tungstate * scintillator * light yield * doping, PET Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.224, year: 2005

  2. A high resolution electromagnetic calorimeter based on lead-tungstate crystals

    Aleksandrov, D. V.; Burachas, S.F.; Ippolitov, M.S.; Mareš, Jiří A.; Polák, Karel

    2005-01-01

    Roč. 550, - (2005), s. 169-184. ISSN 0168-9002 Institutional research plan: CEZ:AV0Z10100521 Keywords : PbWO 3 * high resolution electromagnetic calorimeter Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.224, year: 2005

  3. Annealing induced absorption phenomena in PbWO.sub.4 ./sub

    Boháček, Pavel; Nikl, Martin

    2005-01-01

    Roč. 537, - (2005), s. 86-88. ISSN 0168-9002 Grant ostatní: NATO(XX) SfP 973510 Institutional research plan: CEZ:AV0Z10100521 Keywords : Lead tungstate * annealing * absorption Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.224, year: 2005

  4. Subtyping Cryptosporidium ubiquitum, a Zoonotic Pathogen Emerging in Humans

    Li, N.; Alderisio, K.; Elwin, K.; Cebelinski, E.; Chalmers, R.; Santin, M.; Fayer, R.; Kváč, Martin; Ryan, U.; Sak, Bohumil; Stanko, M.; Guo, Y.; Wang, L.; Zhang, L.; Cai, J.; Roellig, D.; Feng, Y.

    2014-01-01

    Roč. 20, č. 2 (2014), s. 217-224. ISSN 1080-6040 R&D Projects: GA MŠk(CZ) LH11061 Institutional support: RVO:60077344 Keywords : cervine genotype * source tracking * small mammals Subject RIV: EE - Microbiology, Virology Impact factor: 6.751, year: 2014

  5. Strichartz Estimates for the Schrödinger Propagator for the Laguerre Operator

    Vijay Kumar Sohani

    2013-11-01

    We obtain homogeneous Strichartz estimate for the Schrödinger propagator $e^{-itL_}$ for the Laguerre operator $L_$ on $\\mathbb{R}^n_+$. We follow regularization technique as introduced in J. Funct. Anal. 224(2) (2005) 371–385. We also establish inhomogeneous Strichartz estimates for different admissible pairs.

  6. Nejen protektorátní léta Františka Zavřela

    Burget, Eduard

    Červený Kostelec: Pavel Mervart, 2011 - (Magincová, D.), s. 201-224 ISBN 978-80-87378-79-3 Institutional research plan: CEZ:AV0Z90560517 Keywords : Czech literature * Zavřel, František Subject RIV: AJ - Letters, Mass-media, Audiovision

  7. 49 CFR 571.223 - Standard No. 223; Rear impact guards.

    2010-10-01

    ... calculating the shaded area bounded by the curve in the force vs. deflection diagram and the abscissa (X-axis... the distance that the striking vehicle's front end slides under the rear end of the impacted vehicle... forward of the vehicle's rear extremity, as defined in S4 of 49 CFR 571.224, Rear Impact Protection....

  8. Krize, globální civilizace, rizika a transformace

    Suša, Oleg

    PrahaBratislava : Filosofia, 2014 - (Dinuš, P.; Hohoš, L.; Hrubec, M.), s. 29-50 ISBN 978-80-7007-413-8; ISBN 978-80-224-1371-8 Institutional support: RVO:67985955 Keywords : Crisis * global civilization * risks * transformations Subject RIV: AA - Philosophy ; Religion

  9. Barokní kořeny české humanistické politiky

    Förster, Josef

    Bratislava: Veda, 2006 - (Sedová, T.), s. 363-367 ISBN 80-224-0907-3. [Sociálne vedy a humanistika očami mladých. Třešť (CZ), 14.03.2005-16.03.2005] Institutional research plan: CEZ:AV0Z90090514 Keywords : Politic al philosophy * Jesuits Subject RIV: AA - Philosophy ; Religion

  10. Kant v analytické a kontinentální filosofii

    Chotaš, Jiří

    Praha: Filosofia, 2005 - (Nitsche, M.; Sousedík, P.; Šimsa, M.), s. 79-98 ISBN 80-7007-224-5 Institutional research plan: CEZ:AV0Z90090514 Keywords : descriptive * metaphysics * epistemology Subject RIV: AA - Philosophy ; Religion

  11. Ilias Arie »Zefiretti lusinghieri«. Eine Prager Einfügung im Idomeneo-Autograph

    Jonášová, Milada

    Tutzing: Hans Schneider , 2010 - (Schmid, M.), s. 195-224 ISBN 9783862960019 R&D Projects: GA ČR GA408/09/2006 Institutional research plan: CEZ:AV0Z90580513 Keywords : Mozart´ autograph * Idomeneo * aria of Ilia * Zeffiretti lusinghieri * Prague copyist Subject RIV: AL - Art, Architecture, Cultural Heritage

  12. Synthesis of hyperbranched copolyimides and their application as selective layers in composite membranes

    Peter, Jakub; Kosmala, Barbara; Bleha, Miroslav

    Oviedo : Universidad de Oviedo, 2008 - (Luque, S.; Álvarez, J.), s. 224-225 ISBN 978-84-691-3670-6. [Engineering with Membranes 2008 - Membrane Processes: Development, Monitoring and Modelling. Algarve (PT), 25.05.2008-28.05.2008] Institutional research plan: CEZ:AV0Z40500505 Keywords : hyperbranched * polyimides * gas separation Subject RIV: CD - Macromolecular Chemistry

  13. AcEST: DK955842 [AcEST

    Full Text Available TST39A01NGRL0024_C20 553 Adiantum capillus-veneris mRNA. clone: TST39A01NGRL0024_C20. 5' end seq ... synthase, chloroplastic OS=Arabidopsis thaliana GN=CSR ... 1.2 PE=1 SV=1 Length = 670 Score = 224 bits (571), ...

  14. Understanding Green Purchase Behavior: College Students and Socialization Agents

    Yan, Ruoh-Nan; Xu, Huimin

    2010-01-01

    Taking the perspective of consumer socialization theory, this study examined the influences of different socialization agents on consumers' purchases of green products. A total of 224 surveys were distributed to students enrolled in a business-related course at a major university in the northeastern United States. The objectives were twofold. The…

  15. Westerbork Ultra-Deep Survey of HI at z=0.2

    Verheijen, Marc; Deshev, Boris; van Gorkom, Jacqueline; Poggianti, Bianca; Chung, Aeree; Cybulski, Ryan; Dwarakanath, K. S.; Montero-Castano, Maria; Morrison, Glenn; Schiminovich, David; Szomoru, Arpad; Yun, Min

    2010-01-01

    In this contribution, we present some preliminary observational results from the completed ultra-deep survey of 21cm emission from neutral hydrogen at redshifts z=0.164-0.224 with the Westerbork Synthesis Radio Telescope. In two separate fields, a total of 160 individual galaxies has been detected i

  16. Morro do Ferro

    Concentration of Ra224 e Rn220 was measured in 'Morro do Ferro', a region of high natural radioactivity in Brazil. Plants, soils and animals (rodents, scorpions) were taken as samples and radioactive concentrations were found up to 500.000 times the levels of natural occurrences. Histological examinations in rats revealed no abnormalities

  17. Gallegos and Kyle: Five Thousand Years of Maritime Subsistence at CA-SDI-48, on Ballast Point, San Diego County, California

    Warren, Claude N.

    2007-01-01

    Five Thousand Years of Maritime Subsistence at CA-SDI-48, on Ballast Point, San Diego County, California. Dennis Gallegos and Carolyn Kyle. Salinas: Coyote Press, 1998. [Archives of California Prehistory No. 40.] Xiv + 224 pp., 32 figs., 86 tables, 1 appendix. $23.00, (paper).

  18. A theoretical analysis of how segmentation of dynamic visualizations optimizes students' learning

    Spanjers, Ingrid; Van Gog, Tamara; Van Merriënboer, Jeroen

    2010-01-01

    Spanjers, I. A. E., Van Gog, T., & Van Merriënboer, J. J. G. (2010). A theoretical analysis of how segmentation of dynamic visualizations optimizes students’ learning. Educational Psychology Review, 22(4), 411-423. doi:10.1007/s10648-010-9135-6

  19. AcEST: DK957907 [AcEST

    Full Text Available ribosomal protein S18 OS=Branchiostoma ... 224 3e-58 sp|Q8IT98|RS18_AEQIR 40S ribosomal protein S18 OS=Aequip...GQH Sbjct: 121 RGLRHYWGLRVRGQH 135 >sp|Q8IT98|RS18_AEQIR 40S ribosomal protein S18 OS=Aequipecten irradians

  20. AcEST: DK954650 [AcEST

    Full Text Available ISP0|RS18_BRABE 40S ribosomal protein S18 OS=Branchiostoma ... 224 4e-58 sp|Q8IT98|RS18_AEQIR 40S ribosomal protein S18 OS=Aequip...QH 433 RGLRHYWGLRVRGQH Sbjct: 121 RGLRHYWGLRVRGQH 135 >sp|Q8IT98|RS18_AEQIR 40S ribosomal protein S18 OS=Aequip

  1. AcEST: DK955115 [AcEST

    Full Text Available OS=Branchiostoma ... 224 3e-58 sp|Q8IT98|RS18_AEQIR 40S ribosomal protein S18 OS=Aequipecten ir... 217 3e-5...GLRVRGQH 135 >sp|Q8IT98|RS18_AEQIR 40S ribosomal protein S18 OS=Aequipecten irradians GN=RPS18 PE=2 SV=1 Len

  2. AcEST: DK958346 [AcEST

    Full Text Available E 40S ribosomal protein S18 OS=Branchiostoma ... 224 4e-58 sp|Q8IT98|RS18_AEQIR 40S ribosomal protein S18 OS=Aequip...GLRVRGQH Sbjct: 121 RGLRHYWGLRVRGQH 135 >sp|Q8IT98|RS18_AEQIR 40S ribosomal protein S18 OS=Aequipecten irrad

  3. IonCCD Detector for Miniature Sector-Field Mass Spectrometer : Investigation of Peak Shape and Detector Surface Artifacts Induced by keV Ion Detection

    Hadjar, Omar; Schlatholter, Thomas; Davila, Stephen; Catledge, Shane A.; Kuhn, Ken; Kassan, Scott; Kibelka, Gottfried; Cameron, Chad; Verbeck, Guido F.

    2011-01-01

    A recently described ion charge coupled device detector IonCCD (Sinha and Wadsworth, Rev. Sci. Instrum. 76(2), 2005; Hadjar, J. Am. Soc. Mass Spectrom. 22(4), 612-624, 2011) is implemented in a miniature mass spectrometer of sector-field instrument type and Mattauch-Herzog (MH)-geometry (Rev. Sci. I

  4. Long-term development of cultural landscape in Central Bohemia as a co-evolution of human impacts and natural processes. Outline of an interdisciplinary project

    Pokorný, Petr; Dreslerová, Dagmar

    2008-01-01

    Roč. 2008, č. 2 (2008), s. 224-225. ISSN 0946-8978. [International Palynological Congress /12./. 30.08.2008-05.09.2008, Bonn] R&D Projects: GA AV ČR IAAX00020701 Institutional research plan: CEZ:AV0Z80020508 Keywords : cultural landscape * palaeoecology * pollen analyses Subject RIV: EH - Ecology, Behaviour

  5. Drug: D04335 [KEGG MEDICUS

    Full Text Available idual organs 22 Respiratory organ agents 224 Antitussives and expectorants 2241 Phytochemical agents D04335 Cherry bark extract CAS: 8000-44-0 PubChem: 17398058 ... ...egory: 2241 Component of Brocin codeine (TN) Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting indiv

  6. The Journal of Computer-Aided Molecular Design: a bibliometric note

    Willett, P.

    2012-01-01

    Summarizes the articles in, and the citations to, volumes 2-24 of the Journal of Computer-Aided Molecular Design. The citations to the journal come from almost 2000 different sources that span a very wide range of academic subjects, with the most heavily cited articles being descriptions of software systems and of computational methods.

  7. Aeronautical engineering: A continuing bibliography with indexes (supplement 317)

    1995-01-01

    This bibliography lists 224 reports, articles, and other documents introduced into the NASA scientific and technical information system in May 1995. Subject coverage includes: design, construction and testing of aircraft and aircraft engines; aircraft components, equipment, and systems; ground support systems; and theoretical and applied aspects of aerodynamics and general fluid dynamics.

  8. Increased expression of chemokine receptors CCR1 and CCR3 in nasal polyps: molecular basis for recruitment of the granulocyte infiltrate

    Fundová, Petra; Funda, David; Kovář, D.; Holý, R.; Navara, M.; Tlaskalová-Hogenová, Helena

    2013-01-01

    Roč. 58, č. 3 (2013), s. 219-224. ISSN 0015-5632 R&D Projects: GA MZd NS10054 Institutional support: RVO:61388971 Keywords : INTESTINAL EPITHELIAL-CELLS * GM-CSF * TOLL-LIKE RECEPTORS Subject RIV: EE - Microbiology, Virology Impact factor: 1.145, year: 2013

  9. Forest response to increasing typhoon activity on the Korean peninsula: evidence from oak tree-rings

    Altman, Jan; Doležal, Jiří; Černý, Tomáš; Song, J.-S.

    2013-01-01

    Roč. 19, č. 2 (2013), s. 498-504. ISSN 1354-1013 R&D Projects: GA ČR GAP504/12/1952; GA ČR GA206/05/0119 Institutional support: RVO:67985939 Keywords : climate change * typhoon * tree-ring analyzes Subject RIV: EH - Ecology, Behaviour Impact factor: 8.224, year: 2013

  10. Notes to the catalogue of spiders of the Czech Republic

    Růžička, Vlastimil; Buchar, J.

    Budapest : Plant Protection Institute and Berzsenyi College, 2004 - (Samu, F.; Szinetár, C.), s. 221-224 ISBN 963 214 791 X. [European Colloquium of Arachnology /20./. Szombathely (HU), 22.07.2002-26.07.2002] Institutional research plan: CEZ:AV0Z5007907 Keywords : Czech Republic * spiders * catalogue Subject RIV: EG - Zoology

  11. Soil Nitrogen Response to Coupling Cover Crops with Manure Injection

    Coupling winter small grain cover crops (CC) with manure (M) application may increase retention of manure nitrogen (N) in corn-soybean cropping systems. The objective of this research was to quantify soil N changes after application of liquid swine M (Sus scrofa L.) at target N rates of 112, 224, an...

  12. Enhancing Nutrient Cycling by Coupling Cover Crops with Manure Injection

    Coupling winter small grain cover crops (CC) with liquid manure injection may increase manure nutrient capture. The objectives of this research were to quantify manure injection effects using target manure N rates of 112, 224, and 336 kg N ha-1 on CC plant density, fall and spring shoot biomass, N, ...

  13. Některé situační, strategické a textově typologické charakteristiky komunikace na www chatu

    Hoffmannová, Jana; Müllerová, Olga

    Ostrava : Ostravská univerzita, 2006, s. 159-224 ISBN 80-7368-253-2 Grant ostatní: GA ČR(CZ) GA405/04/1035 Institutional research plan: CEZ:AV0Z90610518 Keywords : chat communication * strategies * text types Subject RIV: AI - Linguistics

  14. Trialog o revoluci a transformaci

    Dvořáková, V.; Hrubec, Marek; Keller, J.

    PrahaBratislava: Filosofia, 2014 - (Dinuš, P.; Hohoš, L.; Hrubec, M.), s. 11-28 ISBN 978-80-7007-413-8; ISBN 978-80-224-1371-8 Institutional support: RVO:67985955 Keywords : revolution * transformation * social change * regime change Subject RIV: AA - Philosophy ; Religion

  15. Analysis of Petrol and Diesel Vapor Using Selective Ion Flow Tube/Mass Spectrometry

    Ping, CH.; Weijun, Z.; Yaman, CH.; Španěl, Patrik; Smith, D.

    2003-01-01

    Roč. 5, - (2003), s. 548-551. ISSN 0253-3820 Institutional research plan: CEZ:AV0Z4040901 Keywords : selected ion flow tube/mass spectrometry * fuel vapor Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 0.224, year: 2003

  16. Software News and Update MOLCAS 7: The Next Generation

    Aquilante, F.; De Vico, L.; Ferré, N.; Ghigo, G.; Malmqvist, P. A.; Neogrady, P.; Pedersen, T. B.; Pitoňák, Michal; Reiher, M.; Roos, B. O.; Serrano-Andrés, L.; Urban, M.; Veryazov, V.; Lindh, R.

    2010-01-01

    Roč. 31, č. 1 (2010), s. 224-247. ISSN 0192-8651 R&D Projects: GA MŠk LC512 Institutional research plan: CEZ:AV0Z40550506 Keywords : MOLCAS * Cholesky decomposition * coupled cluster Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 4.050, year: 2010

  17. Kinematic behaviour of a large earthflow defined by surface displacement monitoring, DEM differencing, and ERT imaging

    Prokešová, R.; Kardoš, M.; Tábořík, Petr; Medveďová, A.; Stacke, V.; Chudý, F.

    2014-01-01

    Roč. 224, NOV 1 (2014), s. 86-101. ISSN 0169-555X R&D Projects: GA MŠk LM2010008 Institutional support: RVO:67985891 Keywords : earthflow * surface displacement * strain modelling * DEM differencing * kinematic behaviour Subject RIV: DE - Earth Magnetism, Geodesy, Geography Impact factor: 2.577, year: 2013

  18. Obojživelníci

    Matěnová, V.; Matěna, Josef

    Praha : Baset, 2006 - (Dudák, V.), s. 221-224 ISBN 80-7340-091-X. - (Krajina a lidé) Institutional research plan: CEZ:AV0Z60170517 Keywords : South Bohemia * Novohradské Mountains * Amphibians * faunistics * ecology Subject RIV: EG - Zoology

  19. Zbojníci Miloše Jiránka. To nejlepší z moderní české grafiky

    Winter, Tomáš

    Praha: Národní galerie, 2012 - (Volrábová, A.), 142-148, 224-226 ISBN 978-80-7035-519-0 Institutional support: RVO:68378033 Keywords : Czech art of 20th century * national identity * myth Subject RIV: AL - Art, Architecture, Cultural Heritage

  20. Gender Differences and E-commerce Behavior and Perceptions

    Kurt Schimmel,DBA; Jeananne Nicholls

    2003-01-01

    This paper examines the existence of gender differences regarding the perceptions of the benefits and concerns of shopping on-line. A survey of 224 internet shoppers was conducted and the results indicate that there are only slight differences between the genders regarding on-line shopping behavior and no differences in actual shopping behavior.