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Sample records for actinium 214

  1. CJA 214 NEW Tutorials /cja214dotcom

    ndn58nyt

    2015-01-01

          CJA 214 Entire Course(New) For more course tutorials visit www.cja214.com   CJA 214 Week 1 Individual Assignment Police History Paper CJA 214 Week 2 Individual Assignment Police Department Roles and Functions Paper CJA 214 Week 2 Team Assignment Police Department Organization Presentation CJA 214 Week 3 Individual Assignment Officer Recruitment and Selection Assignment CJA 214 Week 3 Team Assignment Policing Culture Paper CJA 2...

  2. Extraction of actinium with di-(2-ethylhexyl)phosphoric acid from hydrochloric and nitric acid solutions

    The extraction of actinium with HDEHP from Cl- and NO3- systems has been investigated. It was found that extraction of actinium from HCl solutions is much better than from HNO3 solutions. Stability constants of actinium complexes Ac(X-)+2 with Cl- and NO3- ligands were determined. Our results show that the actinium formed less stable complexes with Cl- than with NO3- ligands. 5 refs., 3 figs., 1 tab. (author)

  3. The sorption of polonium, actinium and protactinium onto geological materials

    This paper describes a combined experimental and modeling program of generic sorption studies to increase confidence in the performance assessment for a potential high-level radioactive waste repository in Japan. The sorption of polonium, actinium and protactinium onto geological materials has been investigated. Sorption of these radioelements onto bentonite, tuff and granodiorite from equilibrated de-ionized water was studied under reducing conditions at room temperature. In addition, the sorption of actinium and protactinium was investigated at 60 C. Thermodynamic chemical modeling was carried out to aid interpretation of the results

  4. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    Fry, C; Thoennessen, M

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  5. Separation of Actinium 227 from the uranium minerals

    The purpose of this work was to separate Actinium 227, whose content is 18%, from the mineral carnotite found in Gomez Chihuahua mountain range in Mexico. The mineral before processing is is pre-concentrated and passed, first through anionic exchange resins, later the eluate obtained is passed through cationic resins. The resins were 20-50 MESH QOWEX and 100-200 MESH 50 X 8-20 in some cased 200-400 MESH AG 50W-X8, 1X8 in other cases. The eluates from the ionic exchange were electrodeposited on stainless steel polished disc cathode and platinum electrode as anode; under a current ODF 10mA for 2.5 to 5 hours and of 100mA for .5 of an hour. it was possible to identify the Actinium 227 by means of its descendents, TH-227 and RA-223, through alpha spectroscopy. Due to the radiochemical purity which the electro deposits were obtained the Actinium 227 was low and was not quantitatively determined. A large majority of the members of the natural radioactive series 3 were identified and even alpha energies reported in the literature with very low percentages of non-identified emissions were observed. We conclude that a more precise study is needed concerning ionic exchange and electrodeposit to obtain an Actinium 227 of radiochemical purity. (Author)

  6. Spectroscopic and computational investigation of actinium coordination chemistry.

    Ferrier, Maryline G; Batista, Enrique R; Berg, John M; Birnbaum, Eva R; Cross, Justin N; Engle, Jonathan W; La Pierre, Henry S; Kozimor, Stosh A; Lezama Pacheco, Juan S; Stein, Benjamin W; Stieber, S Chantal E; Wilson, Justin J

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, Ac(III) reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between Ac(III) and Am(III) in HCl solutions indicate Ac(III) coordinates more inner-sphere Cl(1-) ligands (3.2±1.1) than Am(III) (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique Ac(III) chemical behaviour. PMID:27531582

  7. Production of high-purity radium-223 from legacy actinium-beryllium neutron sources.

    Soderquist, Chuck Z; McNamara, Bruce K; Fisher, Darrell R

    2012-07-01

    Radium-223 is a short-lived alpha-particle-emitting radionuclide with potential applications in cancer treatment. Research to develop new radiopharmaceuticals employing (223)Ra has been hindered by poor availability due to the small quantities of parent actinium-227 available world-wide. The purpose of this study was to develop innovative and cost-effective methods to obtain high-purity (223)Ra from (227)Ac. We obtained (227)Ac from two surplus actinium-beryllium neutron generators. We retrieved the actinium/beryllium buttons from the sources and dissolved them in a sulfuric-nitric acid solution. A crude actinium solid was recovered from the solution by coprecipitation with thorium fluoride, leaving beryllium in solution. The crude actinium was purified to provide about 40 milligrams of actinium nitrate using anion exchange in methanol-water-nitric acid solution. The purified actinium was then used to generate high-purity (223)Ra. We extracted (223)Ra using anion exchange in a methanol-water-nitric acid solution. After the radium was separated, actinium and thorium were then eluted from the column and dried for interim storage. This single-pass separation produces high purity, carrier-free (223)Ra product, and does not disturb the (227)Ac/(227)Th equilibrium. A high purity, carrier-free (227)Th was also obtained from the actinium using a similar anion exchange in nitric acid. These methods enable efficient production of (223)Ra for research and new alpha-emitter radiopharmaceutical development. PMID:22697483

  8. CJA 214 NEW UOP Course Tutorial / cja214dotcom

    vasanthi03

    2015-01-01

    CJA 214 Entire Course(New) For more course tutorials visit www.cja214.com   CJA 214 Week 1 Individual Assignment Police History Paper CJA 214 Week 2 Individual Assignment Police Department Roles and Functions Paper CJA 214 Week 2 Team Assignment Police Department Organization Presentation CJA 214 Week 3 Individual Assignment Officer Recruitment and Selection Assignment CJA 214 Week 3 Team Assignment Policing Culture Paper CJA 214 Week 4 Individual Assi...

  9. Radium, thorium, and actinium extraction from seawater using an improved manganese-oxide-coated fiber

    Laboratory experiments were conducted to determine the efficiency with which improved manganese-oxide-coated acrylic fibers extract radium, thorium, and actinium from seawater. Tests were made using surface seawater spiked with 227Ac, 227Th and 223Ra. For sample volumes of approximately 30 liters and flow rates up to 0.5 liters per minute, radium and actinium are removed quantitatively. Approximately 80-95% of the thorium is removed under these same conditions. (Auth.)

  10. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  11. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces ∼100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 GeV protons

  12. Neutron-Induced Fission of Actinium-227, Protactinium-231 and Neptunium-237: Mass Distribution

    Results of radiochemical studies on the mass distribution in the neutron-induced fission of actinium-227, protactinium-231 and neptunium-237 have been presented. This work has been carried out as part of a programme to determine the mass distribution in the fission of heavy elements as a function of Z and A. All irradiations have been carried out in the core of the swimming-pool type reactor APSARA with cadmium shielding wherever necessary. Relative yields of several fission product nuclides have been obtained by a method involving a comparison of the fission product activities from the respective targets with those formed from uranium-235 simultaneously irradiated. Thermal-neutron fission yields of uranium-235 have been assumed. These results indicate a predominantly asymmetric mass distribution in all the three cases, and also a distinct though small symmetric peak in the case of actinium-227. (author)

  13. A new method for the determination of low-level actinium-227 in geological samples

    We developed a new method for the determination of 227Ac in geological samples. The method uses extraction chromatographic techniques and alpha-spectrometry and is applicable for a range of natural matrices. Here we report on the procedure and results of the analysis of water (fresh and seawater) and rock samples. Water samples were acidified and rock samples underwent total dissolution via acid leaching. A DGA (N,N,N',N'-tetra-n-octyldiglycolamide) extraction chromatographic column was used for the separation of actinium. The actinium fraction was prepared for alpha spectrometric measurement via cerium fluoride micro-precipitation. Recoveries of actinium in water samples were 80 ± 8 % (number of analyses n = 14) and in rock samples 70 ± 12 % (n = 30). The minimum detectable activities (MDA) were 0.017-0.5 Bq kg-1 for both matrices. Rock sample 227Ac activities ranged from 0.17 to 8.3 Bq kg-1 and water sample activities ranged from below MDA values to 14 Bq kg-1of 227Ac. From the analysis of several standard rock and water samples with the method we found very good agreement between our results and certified values. (author)

  14. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    Momeni, M.H.

    1981-09-01

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore.

  15. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore

  16. 22 CFR 214.34 - Public participation.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Public participation. 214.34 Section 214.34... Committees § 214.34 Public participation. (a) Each advisory committee meeting is to be open to the public except where: (1) The Director, OMB, has determined that public notice of a meeting would be...

  17. 49 CFR 214.323 - Foul time.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Foul time. 214.323 Section 214.323 Transportation... TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.323 Foul time. Working limits established on controlled track through the use of foul time procedures shall comply with the...

  18. 49 CFR 214.115 - Foot protection.

    2010-10-01

    ...(a) and 1 CFR part 51. Copies may be obtained from American National Standards Institute, 25 West... 49 Transportation 4 2010-10-01 2010-10-01 false Foot protection. 214.115 Section 214.115..., DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Bridge Worker Safety Standards § 214.115...

  19. 49 CFR 214.325 - Train coordination.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Train coordination. 214.325 Section 214.325..., DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.325 Train coordination. Working limits established by a roadway worker through the use of train coordination shall comply with...

  20. 23 CFR 646.214 - Design.

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Design. 646.214 Section 646.214 Highways FEDERAL HIGHWAY... Projects § 646.214 Design. (a) General. (1) Facilities that are the responsibility of the railroad for maintenance and operation shall conform to the specifications and design standards used by the railroad in...

  1. In-source laser spectroscopy developments at TRILIS—towards spectroscopy on actinium and scandium

    Resonance Ionization Laser Ion Sources (RILIS) have become a versatile tool for production and study of exotic nuclides at Isotope Separator On-Line (ISOL) facilities such as ISAC at TRIUMF. The recent development and addition of a grating tuned spectroscopy laser to the TRIUMF RILIS solid state laser system allows for wide range spectral scans to investigate atomic structures on short lived isotopes, e.g., those from the element actinium, produced in uranium targets at ISAC. In addition, development of new and improved laser ionization schemes for rare isotope production at ISAC is ongoing. Here spectroscopic studies on bound states, Rydberg states and autoionizing (AI) resonances on scandium using the existing off-line capabilities are reported. These results allowed to identify a suitable ionization scheme for scandium via excitation into an autoionizing state at 58,104 cm − 1 which has subsequently been used for ionization of on-line produced exotic scandium isotopes.

  2. 24 CFR 214.500 - Audit.

    2010-04-01

    ... PROGRAM Other Federal Requirements § 214.500 Audit. Housing counseling grant recipients and subrecipients shall be subject to the audit requirements contained in 24 CFR parts 84 and 85. HUD must be provided a... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Audit. 214.500 Section...

  3. 40 CFR 94.214 - Production engines.

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Production engines. 94.214 Section 94...) CONTROL OF EMISSIONS FROM MARINE COMPRESSION-IGNITION ENGINES Certification Provisions § 94.214 Production... his/her request, a reasonable number of production engines, as specified by the Administrator....

  4. 24 CFR 214.300 - Counseling services.

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Counseling services. 214.300... HOUSING COUNSELING PROGRAM Program Administration § 214.300 Counseling services. (a) Basic requirements. (1) Agencies must provide counseling to current and potential homeowners and tenants to assist...

  5. 15 CFR 280.214 - Hearings.

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Hearings. 280.214 Section 280.214 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF... proceedings will be taken by reporter or by electronic recording, transcribed and filed with...

  6. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Raeder, S.; Bastin, B.; Block, M.; Creemers, P.; Delahaye, P.; Ferrer, R.; Fléchard, X.; Franchoo, S.; Ghys, L.; Gaffney, L. P.; Granados, C.; Heinke, R.; Hijazi, L.; Huyse, M.; Kron, T.; Kudryavtsev, Yu.; Laatiaoui, M.; Lecesne, N.; Luton, F.; Moore, I. D.; Martinez, Y.; Mogilevskiy, E.; Naubereit, P.; Piot, J.; Rothe, S.; Savajols, H.; Sels, S.; Sonnenschein, V.; Traykov, E.; Van Beveren, C.; Van den Bergh, P.; Van Duppen, P.; Wendt, K.; Zadvornaya, A.

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  7. 49 CFR 214.4 - Preemptive effect.

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY General § 214.4 Preemptive effect. Under 49 U.S.C... regulations in this part preempts any State law, rule, regulation, order, or standard covering the...

  8. Dicty_cDB: AFL214 [Dicty_cDB

    Full Text Available AF (Link to library) AFL214 (Link to dictyBase) - - - Contig-U15510-1 AFL214P (Link to Original ... myhkllnmlkrlfqmdlh mnqmdqfiliq*hfqkhmimvn--- ---lh*imc *tkdkskikfn*cnrrvyhlhflcfrv*pnlqpplq*lvsvplvkviskrr ...

  9. Dicty_cDB: SFI214 [Dicty_cDB

    Full Text Available SF (Link to library) SFI214 (Link to dictyBase) - - - Contig-U15046-1 SFI214E (Link to Original ... nikikiffiflilkmklnnsfffmsvifvfliiiqfst atysksxn*il*kiwi *fgnwriysvfttptpttisttttitst**tq*slw**kkiktk si**rl ...

  10. Dicty_cDB: VFI214 [Dicty_cDB

    Full Text Available VF (Link to library) VFI214 (Link to dictyBase) - - - Contig-U15456-1 VFI214P (Link to Original ... DNA Score E Sequences producing significant alignments : (bits) Value VFI214 (VFI214Q) /CSM/VF/VFI2-A/VFI2 ... DNA Score E Sequences producing significant alignments : (bits) Value N Y16962 |Y16962.1 Dictyostelium dis ...

  11. 40 CFR 86.214-94 - Analytical gases.

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Analytical gases. 86.214-94 Section 86.214-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... Passenger Vehicles; Cold Temperature Test Procedures § 86.214-94 Analytical gases. The provisions of §...

  12. 49 CFR 214.315 - Supervision and communication.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Supervision and communication. 214.315 Section 214... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.315 Supervision and communication. (a) When an employer assigns duties to a roadway worker that call for...

  13. 48 CFR 214.202-5 - Descriptive literature.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Descriptive literature. 214.202-5 Section 214.202-5 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... 214.202-5 Descriptive literature. (c) Requirements of invitation for bids. When brand name or...

  14. 29 CFR 1910.214 - Cooperage machinery. [Reserved

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false Cooperage machinery. 1910.214 Section 1910.214 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS Machinery and Machine Guarding § 1910.214 Cooperage machinery....

  15. 48 CFR 5433.214. - Alternative Dispute Resolution (ADR).

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Alternative Dispute Resolution (ADR). 5433.214. Section 5433.214. Federal Acquisition Regulations System DEFENSE LOGISTICS AGENCY, DEPARTMENT OF DEFENSE PROTESTS, DISPUTES AND APPEALS 5433.214. Alternative Dispute Resolution (ADR)....

  16. 29 CFR 780.214 - Feed sales and other activities.

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Feed sales and other activities. 780.214 Section 780.214... Agriculture as It Relates to Specific Situations Hatchery Operations § 780.214 Feed sales and other activities. In some situations, the hatchery also operates a feed store and furnishes feed to the growers. As...

  17. 25 CFR 214.25 - Forfeiture of lease.

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Forfeiture of lease. 214.25 Section 214.25 Indians BUREAU..., OKLAHOMA, FOR MINING, EXCEPT OIL AND GAS § 214.25 Forfeiture of lease. On the failure of any lessee or assignee to comply with any regulation or any obligation in the lease or assignment, the Secretary of...

  18. 36 CFR 2.14 - Sanitation and refuse.

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Sanitation and refuse. 2.14 Section 2.14 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR RESOURCE PROTECTION, PUBLIC USE AND RECREATION § 2.14 Sanitation and refuse. (a) The following...

  19. 40 CFR 262.214 - Laboratory management plan.

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Laboratory management plan. 262.214 Section 262.214 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... Entities § 262.214 Laboratory management plan. An eligible academic entity must develop and retain...

  20. Civil works 513 - 289 - 214: traffic disturbance

    Optical Fibre Section

    2005-01-01

    The TS/EL group informs you that, in order to create an optical fibre access for the GEANT2 project, the Rutherford road between buildings 289 and 214 will be closed to the public on the 13th of July 2005. Part of the Sophora parking will be closed during the works (week 28, 11th - 15th July). Please respect the road signs put into place. For more information, please contact 160484. Optical Fibre Section, TS/EL

  1. 32 CFR Appendix A to Part 45 - DD Form 214

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false DD Form 214 A Appendix A to Part 45 National... CERTIFICATE OF RELEASE OR DISCHARGE FROM ACTIVE DUTY (DD FORM 214/5 SERIES) Pt. 45, App. A Appendix A to Part 45—DD Form 214 EC23OC91.003 EC23OC91.004 EC23OC91.005 EC23OC91.006...

  2. 22 CFR 214.37 - Public access to committee records.

    2010-04-01

    ... available for public inspection and copying pursuant to A.I.D. Regulation 12—Public Information (22 CFR part... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Public access to committee records. 214.37... Operation of Advisory Committees § 214.37 Public access to committee records. Records maintained...

  3. Dicty_cDB: AFH214 [Dicty_cDB

    Full Text Available AF (Link to library) AFH214 (Link to dictyBase) - G00045 DDB0184362 Contig-U16412-1 AFH214P (Lin ... r*rtsstscqrsrnskdsl*snhesnlkryv*kscccsrss*ksinyg*i pkis *cgivklg*nl*ii*kkkikn Frame B: tvgllxfyfifglakyiykk ...

  4. 48 CFR 2052.214-72 - Bid evaluation.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Bid evaluation. 2052.214-72... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 2052.214-72 Bid evaluation. As... invitations for bids (paragraph “(f)” of this provision is optional): Bid Evaluation (JAN 1993) (a) Award...

  5. 5 CFR 179.214 - Interest, penalties and administrative costs.

    2010-01-01

    ....C. 3717 and 4 CFR part 101.1 et seq. Penalties and administrative costs will be assessed on all... costs. 179.214 Section 179.214 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE... in part 103 of 4 CFR, chapter II, relating to the compromise of claims (without regard to the...

  6. 24 CFR 214.313 - Housing counseling fees.

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Housing counseling fees. 214.313... HOUSING COUNSELING PROGRAM Program Administration § 214.313 Housing counseling fees. (a) Participating agencies may charge reasonable and customary fees for housing education and counseling services, as long...

  7. Groundwater seepage from the Ranger uranium mine tailings dam: radioisotopes of radium, thorium and actinium. Supervising Scientist report 106

    Monitoring of bores near the Ranger uranium mine tailings dam has revealed deterioration in water quality in several bores since 1983. In a group of bores to the north of the dam, increases have been observed of up to 500 times for sulphate concentrations and of up to 5 times for 226Ra concentrations. Results are presented here of measurements of members of the uranium, thorium and actinium decay series in borewater samples collected between 1985 and 1993. In particular, measurements of all four naturally-occurring radium isotopes have been used in an investigation of the mechanism of radium concentration changes. For the most seepage-affected bores the major findings of the study include: 228Ra/226Ra 223Ra /226Ra and 224Ra/228Ra ratios all increased over the course of the study; barium concentrations show high seasonal variability, being lower in November than May, but strontium concentrations show a steady increase with time. Calculations show that the groundwater is probably saturated with respect to barite but not with respect to celestite or anglesite; sulphide concentrations are low in comparison with sulphate, and are higher in November than in May; and 227Ac concentrations have increased with time, but do not account for the high 223Ra/226Ra ratios. It is concluded on the basis of these observations that increases in Ra isotope concentrations observed in a number of seepage-affected bores arise from increases in salinity leading to desorption of radium from adsorption sites in the vicinity of the bore rather by direct transport of radium from the tailings. Increased salinity is also causing the observed increases in 227Ac and strontium concentrations, while formation of a barite solid phase in the groundwater is causing the removal of some radium from solution. This is the cause of the increasing radium isotope ratios noted above

  8. A novel synthesis of ethanolamine-2-14C

    Ethanolamine-2-14C was prepared by the reduction of benzyloxycarbonyl-glycine-1-14C methyl ester. The reduction was carried out with calcium borohydride and the protecting group was removed by hydrogenolysis. (author)

  9. 49 CFR 214.302 - Information collection requirements.

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.302... the Office of Management and Budget pursuant to the Paperwork Reduction Act of 1995, Public Law...

  10. Automated measurement of radon daughters Bi-214 and Pb-214 in rain water

    Since march 1994 the Institut de Techniques Energetiques, Universitat Politecnica de Catalunya (UPC), has been measuring environmental gamma dose rate and the airborne radon concentration levels outdoors, at the ESCRA Station, which is located in Barcelona. ESCRA simultaneously measures several meteorological parameters as well. As it is well known, the gamma dose rate suffers noticeable increments during rain intervals, which in our case range from 10% to 40%, mainly caused by the deposition of the radon daughters 214Bi and 214Pb. These increments do not seem to be correlated with rain rate, rain interval duration, precipitation volume, or other meteorological parameters. In order to develop models that explain the observed dose enhancement, it is interesting to determine the concentration of gamma emitters in rainwater and, due to relative short half life of the two nuclides mentioned above, this must be done as it rains. To this end, we have developed an on-line gamma spectroscopy system for rainwater. The operation of this device, which has been automated by means of a LabView program, consists of the following steps: first, 250 cm3 of water is collected and , if the rain rate is high enough, is transferred to the measurement tank, a Marinelly-like container located underneath a HPGe solid state detector. All the system is surrounded by a lead shield. Preliminary measurements carried out with this device yielded radon daughter concentrations ranging from 50 Bq/l to 1600 Bq/l. (author)

  11. 47 CFR 90.214 - Transient frequency behavior.

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Transient frequency behavior. 90.214 Section 90... PRIVATE LAND MOBILE RADIO SERVICES General Technical Standards § 90.214 Transient frequency behavior... Behavior for Equipment Designed to Operate on 25 kHz Channels t1 4 ±25.0 kHz 5.0 ms 10.0 ms t2 ±12.5 kHz...

  12. 29 CFR 779.214 - “Business” purpose.

    2010-07-01

    ... RETAILERS OF GOODS OR SERVICES Employment to Which the Act May Apply; Enterprise Coverage Common Business Purpose § 779.214 “Business” purpose. The activities described in section 3(r) are included in an enterprise only when they are performed for a “business” purpose. Activities of eleemosynary, religious,...

  13. 48 CFR 52.214-21 - Descriptive Literature.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Descriptive Literature. 52....214-21 Descriptive Literature. As prescribed in 14.201-6(p)(1), insert the following provision: Descriptive Literature (APR 2002) (a) Descriptive literature, as used in this provision, means...

  14. 48 CFR 1433.214 - Alternative dispute resolution (ADR).

    2010-10-01

    ... GENERAL CONTRACTING REQUIREMENTS PROTESTS, DISPUTES, AND APPEALS Disputes and Appeals 1433.214 Alternative dispute resolution (ADR). DOI strongly encourages the use of ADR in the resolution of disputes in lieu of... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Alternative...

  15. 48 CFR 3033.214 - Alternative dispute resolution (ADR).

    2010-10-01

    ..., DISPUTES, AND APPEALS Disputes and Appeals 3033.214 Alternative dispute resolution (ADR). (c) The Administrative Dispute Resolution Act (ADRA) of 1996, as amended, 5 U.S.C. 571, et seq., authorizes and... informal resolution of disputes, and for other purposes. CBCA guidance on ADR may be obtained at...

  16. 16 CFR 1500.214 - Examinations and investigations; samples.

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Examinations and investigations; samples... § 1500.214 Examinations and investigations; samples. When any officer or employee of the Commission...” includes examinations and tests. (b) The owner of a hazardous substance of which an official sample...

  17. 27 CFR 24.214 - Spanish type blending sherry.

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Spanish type blending... BUREAU, DEPARTMENT OF THE TREASURY LIQUORS WINE Production of Other Than Standard Wine § 24.214 Spanish..., produced under this section, is designated “Spanish Type Blending Sherry.” Upon removal, the...

  18. 48 CFR 852.214-73 - Alternate packaging and packing.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Alternate packaging and....214-73 Alternate packaging and packing. As prescribed in 814.201-6(b)(3), insert the following provision: Alternate Packaging and Packing (JAN 2008) The bidder's offer must clearly indicate the...

  19. 40 CFR 180.214 - Fenthion; tolerances for residues.

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Fenthion; tolerances for residues. 180... PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.214 Fenthion; tolerances for residues. (a) General. Tolerances are established for residues of the...

  20. 12 CFR 347.214 - Branch established under section 5 of the International Banking Act.

    2010-01-01

    ... (12 CFR 211). ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Branch established under section 5 of the International Banking Act. 347.214 Section 347.214 Banks and Banking FEDERAL DEPOSIT INSURANCE...

  1. 12 CFR 741.214 - Report of crime or catastrophic act and Bank Secrecy Act compliance.

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Report of crime or catastrophic act and Bank Secrecy Act compliance. 741.214 Section 741.214 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION... Unions § 741.214 Report of crime or catastrophic act and Bank Secrecy Act compliance. Any credit...

  2. 32 CFR Appendix B to Part 45 - DD Form 214ws

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false DD Form 214ws B Appendix B to Part 45 National... CERTIFICATE OF RELEASE OR DISCHARGE FROM ACTIVE DUTY (DD FORM 214/5 SERIES) Pt. 45, App. B Appendix B to Part 45—DD Form 214ws EC23OC91.007...

  3. 48 CFR 52.214-34 - Submission of Offers in the English Language.

    2010-10-01

    ... the English Language. 52.214-34 Section 52.214-34 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.214-34 Submission of Offers in the English Language. As prescribed in 14.201-6(w), insert the following provision: Submission of Offers in the English Language (APR 1991) Offers...

  4. 40 CFR 2.214 - Defense of Freedom of Information Act suits; participation by affected business.

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Defense of Freedom of Information Act suits; participation by affected business. 2.214 Section 2.214 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PUBLIC INFORMATION Confidentiality of Business Information § 2.214 Defense of Freedom of Information Act...

  5. 48 CFR 1852.214-70 - Caution to offerors furnishing descriptive literature.

    2010-10-01

    ... furnishing descriptive literature. 1852.214-70 Section 1852.214-70 Federal Acquisition Regulations System... CLAUSES Texts of Provisions and Clauses 1852.214-70 Caution to offerors furnishing descriptive literature... Descriptive Literature (DEC 1988) Bidders are cautioned against furnishing as a part of their bids...

  6. 49 CFR 214.335 - On-track safety procedures for roadway work groups.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false On-track safety procedures for roadway work groups. 214.335 Section 214.335 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.335 On-track safety...

  7. Quantification of the 214 Pb and 214 Bi decay products before and after to reach the secular equilibria with the 226 Ra

    In this work a comparison between the 226 Ra concentration and its decay products (214 Pb and 214 Bi) in soil samples is presented before and after that the decay mentioned products reach the equilibria with the radium. Moreover, the obtained daughter/father ratio is presented; and the correction factor for the calculus of the 214 Pb and 214 Bi quantification without being necessary to wait until that the secular equilibria has been established. For the quantification of the concentration of the three radionuclides the gamma spectrometry technique was used. (Author)

  8. Diurnal variations of 218Po, 214Pb, and 214Po and their effect on atmospheric electrical conductivity in the lower atmosphere at Mysore

    The short-lived radon daughters (218Po, 214Pb, 214Bi and 214Po) are natural tracers in the troposphere in particular near the ground surface. They are electrically charged particles and are chemically reactive. As soon as they are formed they get attached to the aerosol particles of the atmosphere. Their behaviour is similar to that of aerosols with respect to their growth, transport, removal processes in the atmosphere. The electrical conductivity of the atmosphere is mainly due to the presence of highly mobile (small) ions. Hence the electrical conductivity of air at near the surface of the earth mainly due to 222Rn, 218Po, 214Pb, 214Bi and 214Po concentrations, and depends on aerosol concentrations and meteorological parameters. The individual radon progeny concentrations (218Po, 214Pb, and 214Po) are measured using Air Flow meter. The concentration of radon in the atmospheric air is measured using Low Level Radon Detection System. The total energy released due to both radon and its progeny is computed in energy units (eV cm-3s-1) and is converted into ion-pair production rate (No. cm-3 s-1), 32 eV being the energy producing one-ion pair. The atmospheric electrical conductivity (both positive and negative) is measured using a Gerdien's apparatus with two identical tubes. The average values of 218Po, 214Pb, and 214Po are respectively 13.70, 1.45 and 1.92 Bq m-3 respectively. The average value of positive and negative electrical conductivity are 5.08 x 10-14U-1 m-1 and 4.67 x 10-14 U-1 m-1. The concentrations of radon, its progeny, and positive and negative conductivity show a similar kind of diurnal variations with maximum in the early morning hours and a minimum during day time. The activity is higher in winter than in summer and rainy season. (author)

  9. MiR-214 inhibits cell growth in hepatocellular carcinoma through suppression of {beta}-catenin

    Wang, Xiaojun [Liver Diseases Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou (China); Chen, Ji [Department of Gastrointestinal Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai (China); Li, Feng [Department of Pathology, Fujian Provincial Hospital, Fuzhou (China); Lin, Yanting [Liver Diseases Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou (China); Zhang, Xiaoping; Lv, Zhongwei [Department of Interventional Therapy, Shanghai 10th People' s Hospital, School of Medicine, Tongji University, Shanghai (China); Jiang, Jiaji, E-mail: jiang_jjcn@yahoo.com.cn [Liver Diseases Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou (China)

    2012-11-30

    Highlights: Black-Right-Pointing-Pointer miR-214 is frequently downregulated in human HCC cell lines and tissues. Black-Right-Pointing-Pointer miR-214 overexpression inhibits HCC cell growth in vitro and in vivo. Black-Right-Pointing-Pointer miR-214 directly targets {beta}-catenin 3 Prime -UTR in HCC cells. Black-Right-Pointing-Pointer miR-214 regulates {beta}-catenin downstream signaling molecules. -- Abstract: Mounting evidence has shown that microRNAs (miRNAs) are implicated in carcinogenesis and can function as oncogenes or tumor suppressor genes in human cancers. Recent profile studies of miRNA expression have documented a deregulation of miRNA (miR-214) in hepatocellular carcinoma (HCC). However, its potential functions and underlying mechanisms in hepatocarcinogenesis remain largely unknown. Here, we confirmed that miR-214 is significantly downregulated in HCC cells and specimens. Ectopic overexpression of miR-214 inhibited proliferation of HCC cells in vitro and tumorigenicity in vivo. Further studies revealed that miR-214 could directly target the 3 Prime -untranslated region (3 Prime -UTR) of {beta}-catenin mRNA and suppress its protein expression. Similar to the restoring miR-214 expression, {beta}-catenin downregulation inhibited cell growth, whereas restoring the {beta}-catenin expression abolished the function of miR-214. Moreover, miR-214-mediated reduction of {beta}-catenin resulted in suppression of several downstream genes including c-Myc, cyclinD1, TCF-1, and LEF-1. These findings indicate that miR-214 serves as tumor suppressor and plays substantial roles in inhibiting the tumorigenesis of HCC through suppression of {beta}-catenin. Given these, miR-214 may serve as a useful prognostic or therapeutic target for treatment of HCC.

  10. MiR-214 inhibits cell growth in hepatocellular carcinoma through suppression of β-catenin

    Highlights: ► miR-214 is frequently downregulated in human HCC cell lines and tissues. ► miR-214 overexpression inhibits HCC cell growth in vitro and in vivo. ► miR-214 directly targets β-catenin 3′-UTR in HCC cells. ► miR-214 regulates β-catenin downstream signaling molecules. -- Abstract: Mounting evidence has shown that microRNAs (miRNAs) are implicated in carcinogenesis and can function as oncogenes or tumor suppressor genes in human cancers. Recent profile studies of miRNA expression have documented a deregulation of miRNA (miR-214) in hepatocellular carcinoma (HCC). However, its potential functions and underlying mechanisms in hepatocarcinogenesis remain largely unknown. Here, we confirmed that miR-214 is significantly downregulated in HCC cells and specimens. Ectopic overexpression of miR-214 inhibited proliferation of HCC cells in vitro and tumorigenicity in vivo. Further studies revealed that miR-214 could directly target the 3′-untranslated region (3′-UTR) of β-catenin mRNA and suppress its protein expression. Similar to the restoring miR-214 expression, β-catenin downregulation inhibited cell growth, whereas restoring the β-catenin expression abolished the function of miR-214. Moreover, miR-214-mediated reduction of β-catenin resulted in suppression of several downstream genes including c-Myc, cyclinD1, TCF-1, and LEF-1. These findings indicate that miR-214 serves as tumor suppressor and plays substantial roles in inhibiting the tumorigenesis of HCC through suppression of β-catenin. Given these, miR-214 may serve as a useful prognostic or therapeutic target for treatment of HCC.

  11. Dicty_cDB: AHA214 [Dicty_cDB

    Full Text Available AH (Link to library) AHA214 (Link to dictyBase) - - - Contig-U16495-1 - (Link to Original site) ... omosome 13. 40 1.1 2 AW048636 |AW048636.1 UI-M-BH1-amd -c-12-0-UI.s1 NIH_BMAP_M_S2 Mus musculus cDNA clone ... UI-M-BH1-amd -c-12-0-UI 3', mRNA sequence. 44 2.4 1 AZ941527 |AZ ...

  12. Synthesis of 2-dichloromethyl-2-methyl[2-14C]-1,3-dioxolane

    The labelled compound was prepared by chlorination of [2-14C]acetone obtained from the barium salt of [1-14C]acetic acid by pyrolysis. The reaction product 1,1-dichloro[2-14C]acetone was converted to 2-dichloromethyl-2-methyl[2-14C]-1,3-dioxolane by condensation with ethylene glycol in the presence of thionyl chloride. Radiochemical yield: 62% based on [1-14C]acetic acid. (author) 7 refs

  13. Radon and progeny (214Pb and 214Bi) in urban water-supply systems of Sao Paulo State, Brazil

    Many water-supply systems in South America utilize the waters of the Guarani aquifer at least as part of their networks. However, there is little present knowledge in Brazil of the factors affecting Rn presence in the water supplied for end-users, despite the economic importance of Guarani aquifer. 222Rn analyzes of 162 water samples were performed at 8 municipalities in Sao Paulo State, Brazil, with the aim of investigating the major factors affecting its presence in solution. The 222Rn activity concentration ranged from 0.04 up to 204.9 Bq/L, with three samples exceeding the World Health Organization maximum limit of 100 Bq/L. Aeration was confirmed as the most important factor for Rn release, as expected due to its gaseous nature. Accumulation in pipes and stratification in the water column were other significant factors explaining the data obtained in some circumstances. The Rn daughters 214Pb and 214Bi were also determined in a set of selected samples and their presence was directly related to the occurrence of Rn dissolved in water

  14. Low level 14C measurements in freshly prepared benzene samples with simultaneous 214Bi/214Po pairs counting for routine 222Rn contamination correction

    In this paper, we present the application of a known method for simultaneous measurements of the 14C and 222Rn in benzene dating samples. Measurements are performed with a laboratory-made multichannel analyzer that records the height of each pulse and the time interval between the subsequent pulses. This feature is used to detect pairs of pulses from two subsequent decays of 222Rn products, 214Bi and 214Po, what occur in less than 800 μs and have amplitudes corresponding to more than 160 keVe. The measured decay pairs' background count rate is 3.4 day−1 which is much larger than the theoretically expected rate of 0.36 day−1, this suggests a possible source of 222Rn in the LSC cocktails. The 214Bi/214Po pairs count rate is used to correct a count rate in the fixed energy 14C window. Prolonged measurements were performed on a set of 4 test samples starting immediately after the benzene synthesis. The obtained results show good reproducibility and high efficiency in detecting 222Rn presence. The measurements of the chemically prepared benzene from the samples tend to be contaminated with 222Rn are also presented and these clearly show the influence the of 222Rn contamination on the 14C activity measurements. - Highlights: • Delayed coincidence was used for the detection of Bi-214/Po-214 pairs. • Measurement of C-14 activity and Rn-222 activity through Bi-214/Po-214 pairs is performed at the same time. • We report significant Rn-222 contamination of benzene obtained from samples

  15. 42 CFR 431.214 - Notice in cases of probable fraud.

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Notice in cases of probable fraud. 431.214 Section... Hearings for Applicants and Recipients Notice § 431.214 Notice in cases of probable fraud. The agency may... indicating that action should be taken because of probable fraud by the recipient; and (b) The facts...

  16. 25 CFR 214.21 - Inspection of lessees' books and records.

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Inspection of lessees' books and records. 214.21 Section... OSAGE RESERVATION LANDS, OKLAHOMA, FOR MINING, EXCEPT OIL AND GAS § 214.21 Inspection of lessees' books... premises for the purpose of inspection, and their books and records showing manner of operations...

  17. 10 CFR 72.214 - List of approved spent fuel storage casks.

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false List of approved spent fuel storage casks. 72.214 Section... STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General License for Storage of Spent Fuel at Power Reactor Sites § 72.214 List of approved...

  18. 46 CFR 199.214 - Immersion suits and thermal protective aids.

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Immersion suits and thermal protective aids. 199.214... Passenger Vessels § 199.214 Immersion suits and thermal protective aids. (a) Each passenger vessel must carry at least three immersion suits approved under approval series 160.171 for each lifeboat on...

  19. 23 CFR 973.214 - Indian lands congestion management system (CMS).

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Indian lands congestion management system (CMS). 973.214... HIGHWAYS MANAGEMENT SYSTEMS PERTAINING TO THE BUREAU OF INDIAN AFFAIRS AND THE INDIAN RESERVATION ROADS PROGRAM Bureau of Indian Affairs Management Systems § 973.214 Indian lands congestion management...

  20. 47 CFR 25.214 - Technical requirements for space stations in the satellite digital audio radio service and...

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Technical requirements for space stations in the satellite digital audio radio service and associated terrestrial repeaters. 25.214 Section 25.214... Technical Standards § 25.214 Technical requirements for space stations in the satellite digital audio...

  1. Octupole coupling and proton-neutron interactions in 214Fr

    Excited states in the odd-odd nucleus 214Fr have been studied using γ-ray and electron spectroscopy following 208Pb(11B,5n) and 205Tl(13C,4n) reactions. Levels were identified to spins of around 36 h and excitation energies of ∼ 8.6 MeV. A number of isomeric states have been measured and g-factors obtained using the TDPAD method. At low spin, semi-empirical shell-model calculations appear to provide a good description of the states observed. An understanding of the structure of higher spin states in terms of the probable yrast configurations requires the addition of two units of spin at an energy of around 2 MeV. States with spins around 30 h are formed by core-excited configurations, with double core-excitation suggested for the highest states observed. The properties of many of the isomeric states can be understood in terms of multiparticle octupole coupling, with the properties of these states well reproduced by multiparticle octupole-coupled shell-model calculations. (orig.)

  2. Photodissociation dynamics of OCS near 214 nm using ion imaging

    Wei, Wei; Wallace, Colin J.; McBane, George C.; North, Simon W.

    2016-07-01

    The OCS photodissociation dynamics of the dominant S(1D2) channel near 214 nm have been studied using velocity map ion imaging. We report a CO vibrational branching ratio of 0.79:0.21 for v = 0:v = 1, indicating substantially higher vibrational excitation than that observed at slightly longer wavelengths. The CO rotational distribution is bimodal for both v = 0 and v = 1, although the bimodality is less pronounced than at longer wavelengths. Vector correlations, including rotational alignment, indicate that absorption to both the 21A' (A) and 11A″ (B) states is important in the lower-j part of the rotational distribution, while only 21A' state absorption contributes to the upper part; this conclusion is consistent with work at longer wavelengths. Classical trajectory calculations including surface hopping reproduce the measured CO rotational distributions and their dependence on wavelength well, though they underestimate the v = 1 population. The calculations indicate that the higher-j peak in the rotational distribution arises from molecules that begin on the 21A' state but make nonadiabatic transitions to the 11A' (X) state during the dissociation, while the lower-j peak arises from direct photodissociation on either the 21A' or the 11A″ states, as found in previous work.

  3. Diurnal variations of 218Po, 214Pb, and 214Po and their effect on atmospheric electrical conductivity in the lower atmosphere at Mysore city, Karnataka State, India

    The short-lived radon daughters (218Po, 214Pb, 214Bi and 214Po) are natural tracers in the troposphere, in particular near the ground surface. They are electrically charged particles and are chemically reactive. As soon as they are formed they get attached to the aerosol particles of the atmosphere. The behavior of radon daughters is similar to that of aerosols with respect to their growth, transport and removal processes in the atmosphere. The electrical conductivity of the atmosphere is mainly due to the presence of highly mobile ions. Galactic cosmic rays are the main source of ionization in the planetary boundary layer; however, near the surface of the earth, ions are produced mainly by decays of natural radioactive gases emanating from the soil surface and by radiations emitted directly from the surface. Hence the electrical conductivity of air near the surface of the earth is mainly due to radiations emitted by 222Rn, 218Po, 214Pb, 214Bi and 214Po, and depends on aerosol concentrations and meteorological parameters. In the present work the diurnal and seasonal variations of radon and its progeny concentrations are studied using Low Level Radon Detection System and Airflow Meter respectively. Atmospheric electrical conductivity of both positive and negative polarities is measured using a Gerdien Condenser. All the measurements were carried out simultaneously at one location in Mysore city (12°N, 76°E), India. The diurnal variation of atmospheric electrical conductivity was found to be similar to that of ion pair production rate estimated from radon and its progeny concentrations with a maximum in the early morning hours and minimum during day time. The annual average concentrations of 222Rn, 218Po, 214Pb, and 214Po at the study location were found to be 21.46, 10.88, 1.78 and 1.80 Bq m−3 respectively. The annual average values of positive and negative atmospheric electrical conductivity were found to be 18.1 and 16.6 f S m−1 respectively. The radon and

  4. Diurnal variations of (218)Po, (214)Pb, and (214)Po and their effect on atmospheric electrical conductivity in the lower atmosphere at Mysore city, Karnataka State, India.

    Pruthvi Rani, K S; Paramesh, L; Chandrashekara, M S

    2014-12-01

    The short-lived radon daughters ((218)Po, (214)Pb, (214)Bi and (214)Po) are natural tracers in the troposphere, in particular near the ground surface. They are electrically charged particles and are chemically reactive. As soon as they are formed they get attached to the aerosol particles of the atmosphere. The behavior of radon daughters is similar to that of aerosols with respect to their growth, transport and removal processes in the atmosphere. The electrical conductivity of the atmosphere is mainly due to the presence of highly mobile ions. Galactic cosmic rays are the main source of ionization in the planetary boundary layer; however, near the surface of the earth, ions are produced mainly by decays of natural radioactive gases emanating from the soil surface and by radiations emitted directly from the surface. Hence the electrical conductivity of air near the surface of the earth is mainly due to radiations emitted by (222)Rn, (218)Po, (214)Pb, (214)Bi and (214)Po, and depends on aerosol concentrations and meteorological parameters. In the present work the diurnal and seasonal variations of radon and its progeny concentrations are studied using Low Level Radon Detection System and Airflow Meter respectively. Atmospheric electrical conductivity of both positive and negative polarities is measured using a Gerdien Condenser. All the measurements were carried out simultaneously at one location in Mysore city (12°N, 76°E), India. The diurnal variation of atmospheric electrical conductivity was found to be similar to that of ion pair production rate estimated from radon and its progeny concentrations with a maximum in the early morning hours and minimum during day time. The annual average concentrations of (222)Rn, (218)Po, (214)Pb, and (214)Po at the study location were found to be 21.46, 10.88, 1.78 and 1.80 Bq m(-3) respectively. The annual average values of positive and negative atmospheric electrical conductivity were found to be 18.1 and 16.6 f S m(-1

  5. Oxidation behaviors of porous Haynes 214 alloy at high temperatures

    The oxidation behaviors of porous Haynes 214 alloy at temperatures from 850 to 1000 °C were investigated. The porous alloys before and after the oxidation were examined by optical microscopy, scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS), X-ray diffraction (XRD) analyses, and X-ray photoelectron spectroscopy (XPS). The oxidation kinetics of the porous alloy approximately follows a parabolic rate law and exhibits two stages controlled by different oxidation courses. Complex oxide scales composed of Cr2O3, NiCr2O4 and Al2O3 are formed on the oxidized porous alloys, and the formation of Cr2O3 on its outer layer is promoted with the oxidation proceeding. The rough surface as well as the micropores in the microstructures of the porous alloy caused by the manufacturing process provides fast diffusion paths for oxygen so as to affect the formation of the oxide layers. Both the maximum pore size and the permeability of the porous alloys decrease with the increase of oxidation temperature and exposure time, which may limit its applications. - Highlights: • Two-stage oxidation kinetics controlled by different oxidation courses is showed. • Oxide scale mainly consists of Cr2O3, NiCr2O4 and Al2O3. • Rough surface and micropores lead to the formation of uneven oxide structure. • Content of Cr2O3 in the outer layer of the scale increases with time at 1000 °C. • Maximum pore size and permeability decrease with increasing temperature and time

  6. Oxidation behaviors of porous Haynes 214 alloy at high temperatures

    Wang, Yan, E-mail: wangyan@csu.edu.cn [School of Aeronautics and Astronautics, Central South University, Changsha 410083 (China); Liu, Yong, E-mail: yonliu@csu.edu.cn [State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083 (China); Tang, Huiping, E-mail: hptang@c-nin.com [State Key Laboratory of Porous Metals Materials, Northwest Institute for Nonferrous Metal Research, Xi' an 710016 (China); Li, Weijie, E-mail: wl347@uowmail.edu.au [Institute for Superconducting and Electronic Materials, University of Wollongong, Wollongong, NSW 2522 (Australia)

    2015-09-15

    The oxidation behaviors of porous Haynes 214 alloy at temperatures from 850 to 1000 °C were investigated. The porous alloys before and after the oxidation were examined by optical microscopy, scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS), X-ray diffraction (XRD) analyses, and X-ray photoelectron spectroscopy (XPS). The oxidation kinetics of the porous alloy approximately follows a parabolic rate law and exhibits two stages controlled by different oxidation courses. Complex oxide scales composed of Cr{sub 2}O{sub 3}, NiCr{sub 2}O{sub 4} and Al{sub 2}O{sub 3} are formed on the oxidized porous alloys, and the formation of Cr{sub 2}O{sub 3} on its outer layer is promoted with the oxidation proceeding. The rough surface as well as the micropores in the microstructures of the porous alloy caused by the manufacturing process provides fast diffusion paths for oxygen so as to affect the formation of the oxide layers. Both the maximum pore size and the permeability of the porous alloys decrease with the increase of oxidation temperature and exposure time, which may limit its applications. - Highlights: • Two-stage oxidation kinetics controlled by different oxidation courses is showed. • Oxide scale mainly consists of Cr{sub 2}O{sub 3}, NiCr{sub 2}O{sub 4} and Al{sub 2}O{sub 3}. • Rough surface and micropores lead to the formation of uneven oxide structure. • Content of Cr{sub 2}O{sub 3} in the outer layer of the scale increases with time at 1000 °C. • Maximum pore size and permeability decrease with increasing temperature and time.

  7. Cavitation erosion resistance of 13/4 and 21-4-N steels

    Akhilesh K Chauhan

    2013-02-01

    Nitrogen strengthened austenitic stainless steel (termed as 21-4-N steel) in as cast and hot rolled conditions has been investigated as an alternative to 13/4 steel (termed as CA6NM) to overcome the problems of cavitation erosion in hydro turbine underwater parts. The cavitation erosion of 21-4-N and 13/4 steels was investigated by means of an ultrasonic vibration processor. The cavitation erosion is highly dependent on microstructure and mechanical properties. The results show that hot rolled 21-4-N steel is more cavitation erosion resistant than the 13/4 and 21-4-N steels in as cast condition. The eroded surfaces were analysed through optical microscope and scanning electron microscope for study of erosion mechanisms.

  8. 8 CFR 214.4 - Denial of certification, denial of recertification or withdrawal of SEVP certification.

    2010-01-01

    ... to comply with 8 CFR 214.3(g)(2). (iii) Failure of a DSO to notify SEVP of the attendance of an F-1 transfer student as required by 8 CFR 214.2(f)(8)(ii). (iv) Failure of a DSO to identify on the Form I-20... certification of a school or school system for the attendance of nonimmigrant students, pursuant to sections...

  9. Dynamic regulation of uncoupling protein 2 expression by microRNA-214 in hepatocellular carcinoma.

    Yu, Guangsheng; Wang, Jianlu; Xu, Kesen; Dong, Jiahong

    2016-07-01

    Gemcitabine (GEM), a commonly used chemotherapeutic agent in hepatocellular carcinoma (HCC) patients, uses oxidative stress induction as a common effector pathway. However, GEM alone or in combination with oxaliplatin hardly renders any survival benefits to HCC patients. We have recently shown that this is part due to the overexpression of the mitochondrial uncoupling protein 2 (UCP2) that in turn mediates resistance to GEM in HCC patients. However, not much is known about regulatory mechanisms underlying UCP2 overexpression in HCC. Differential protein expression in HCC cell lines did not show a concomitant change in UCP2 transcript level, indicating post-transcriptional or post-translational regulatory mechanism. In situ analysis revealed that UCP2 is a putative target of miR-214 miR-214 expression is significantly down-regulated in HCC patient samples as compared with normal adjacent tissues and in cell line, human hepatoblastoma cells (HuH6), with high UCP2 protein expression. We demonstrated using miR-214 mimic and antagomir that the miRNA targeted UCP2 expression by directly targeting the wild-type, but not a miR-214 seed mutant, 3' UTR of UCP2 Overexpression of miR-214 significantly attenuated cell proliferation. Finally, analysis in 20 HCC patients revealed an inverse correlation in expression of UCP2 and miR-214 (Pearson's correlation coefficient, r=-0.9792). Cumulatively, our data indicate that in the context of HCC, miR-214 acts as a putative tumour suppressor by targeting UCP2 and defines a novel mechanism of regulation of UCP2. PMID:27129291

  10. Educational experiment for university students using natural radioactivity. Development of an additional experiment to measure the increase in 214Pb and 214Bi produced from 222Rn

    Although several works have been published to date regarding radiochemistry, most of them have been designed for those who major in subjects related to chemistry or physics and use rather sophisticated methods and apparatus. Education about radiation and radioactivity is also very important for other students because a basic knowledge of radiation and radioactivity is indispensable for understanding environmental problems or energy problems in the future. However, it is not easy to conduct practical work using radioactivity in students' experiments at school or at university because the use of radioactivity is strictly regulated by the law, and equipment such as radiation counters is too expensive for school budgets. From such a viewpoint, we developed several kinds of safe and inexpensive experiments for education using natural radioactivity so that university (or senior high school) students can learn through their practical work without being regulated by the law. For this purpose, radioactive species belonging to the uranium decay series are suitable because these species can be easily obtained from mineral spring water or soil samples. In addition, some of the species such as 214Pb and 214Bi emit beta rays, which are easy to detect, and the half-lives of these which are easy to detect, and the half-lives of these elements can be measured in one or two-hour school activities. This kind of experiment was employed as an ''Educational experiment for radiochemistry'' at Tottori University for nearly fifty students every year. Although the experiment itself was essentially complete, the students did not have the chance to observe how radioactive equilibrium was established. Therefore, we have developed an additional work plan to enable students to observe how 214Pb and 214Bi are produced from 222Rn, and have made this experiment more complete. The educational usefulness of this additional experiment was evaluated and will be presented in section 5. (author)

  11. Measurement of the {sup 214}Po half-life by the DEVIS track setup

    Belov, V. A.; Brakhman, E. V.; Zeldovich, O. Ya.; Karelin, A. K.; Kirichenko, V. V.; Kobyakin, A. S., E-mail: Alexander.Kobyakin@itep.ru; Kozodaeva, O. M.; Kuchenkov, A. V.; Tsvetkova, T. N. [Institute of Theoretical and Experimental Physics (Russian Federation)

    2013-04-15

    Measurement of the {sup 214}Po half-life with the DEVIS track setup at the Institute of Theoretical and Experimental Physics (ITEP, Moscow) by means of a procedure based on determining lifetimes of individual nuclei is described. The value obtained for the {sup 214}Po half-life is 163.8 {+-} 3.0 Micro-Sign s. The possibility of reaching the accuracy of the measurements that is required for testing the statement that the decay of some nuclei has a nonexponential character and the source intensity necessary for this are discussed.

  12. MiR-214 regulates the function of osteoblast under simulated microgravity by targeting ATF4

    Li, Yingxian; Wang, Xiaogang; Li, Qi; Lv, Ke; Wan, Yumin; Li, Yinghui; Bai, Yanqiang

    Background: MicroRNAs (miRNAs) are small fragments of single-stranded RNA containing 18-24 nucleotides, and are generated from endogenous transcripts. MicroRNAs function in post-transcriptional gene silencing by targeting the 3'-untranslated region (UTR) of mRNAs, resulting in translational repression. Growing evidence shows that microRNAs (miRNAs) regu-late various developmental and homeostatic events in vertebrates and invertebrates. Osteoblast differentiation is a key step in proper skeletal development and acquisition of bone mass; How-ever, the physiological role of non-coding small RNAs, especially miRNAs, in osteoblast dif-ferentiation remains elusive. Methods: To study the potential involvement of miRNAs in osteoblast differentiation under stimulated microgravity, we analyzed the expression of 20 bone relative miRNAs using real time PCR platform to find particularly miRNAs whose expression is altered during osteoblast differentiation. TargetScan, miRBase and Miranda were used to predict the target gene of candidate miRNA. To investigate whether ATF4 can be directly targeted by miR-214, we engineered luciferase reporters that have either the wild-type 3'UTRs of these genes, or the mutant UTRs with a 6 base pair (bp) deletion in the target sites. Lastly, to address the in vivo role of miR-214 in bone formation, tail suspension mice model was used to simulate the change of osteoblast function and bone loss. Results: Recent studies have sug-gested that miRNAs might play a role in osteoblast differentiation and bone formation. Here, we identify miR-214 in MC3T3-E1 cells, which is a primary mouse osteoblasts cell line, to promote osteoblast differentiation by repressing Activating Transcription Factor4 (ATF4) ex-pression at the posttranscriptional level. What is more, miR-214 was found to be transcribed in C2C12 cells during bone morphogenetic protein 2-induced (BMP2-induced) osteogenesis, and overexpression of miR-214 attenuated BMP2-induced osteoblastogenesis

  13. miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1

    Xu, Zhengyu [Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai (China); Wang, Tao, E-mail: wangtaohappy2010@sohu.com [Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai (China)

    2014-06-27

    Highlights: • miR-214 is upregulated in human OS tissues and inversely correlated with LZTS1 expression. • miR-214 directly targets LZTS1 by binding to its 3′-UTR. • miR-214 promotes OS cell proliferation, invasion and tumor growth. • Overexpression of LZTS1 reverses miR-214-induced proliferation and invasion of OS cells. - Abstract: Previous studies have shown that miR-214 functions either as an oncogene or a tumor suppressor in various human cancer types. The role of this microRNA in osteosarcoma (OS) is presently unclear. Here, we demonstrated that miR-214 is frequently upregulated in OS specimens, compared with noncancerous bone tissues. Bioinformatics analysis further revealed leucine zipper, putative tumor suppressor 1 (LZTS1) as a potential target of miR-214. Expression patterns of miR-214 were inversely correlated with those of LZTS1 mRNA and protein in OS tissues. Data from reporter assays showed that miR-214 directly binds to the 3′-untranslated region (3′-UTR) of LZTS1 mRNA and suppresses expression at both transcriptional and translational levels. In functional assays, miR-214 promoted OS cell proliferation, invasion and tumor growth in nude mice, which could be reversed by overexpression of LZTS1. Taken together, our data provide compelling evidence that miR-214 functions as an onco-miRNA in OS, and its oncogenic effects are mediated chiefly through downregulation of LZTS1.

  14. 25 CFR 166.214 - Will the BIA notify the permittee of any change in land title status?

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Will the BIA notify the permittee of any change in land title status? 166.214 Section 166.214 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND... permittee of any change in land title status? Yes. We will notify the permittee if a fee patent is issued...

  15. OsCYP21-4, a novel Golgi-resident cyclophilin, increases oxidative stress tolerance in rice

    Hye Sun eCho

    2015-10-01

    Full Text Available OsCYP21-4 is a rice cyclophilin protein that binds to cyclosporine A, an immunosuppressant drug. CYP21-4s in Arabidopsis and rice were previously shown to function as mitochondrial cyclophilins, as determined by TargetP analysis. In the current study, we found that OsCYP21-4-GFP localized to the Golgi, rather than mitochondria, in Nicotiana benthamiana leaves, which was confirmed based on its co-localization with cis Golgi α-ManI-mCherry protein. OsCYP21-4 transcript levels increased in response to treatments with various abiotic stresses and the phytohormone abscisic acid, revealing its stress-responsiveness. CYP21-4 homologs do not possess key peptidyl prolyl cis/trans isomerase (PPIase activity/cyclosporine A (CsA binding residues, and recombinant OsCYP21-4 protein did not convert the synthetic substrate Suc-AAPF-pNA via cis- trans- isomerization in vitro. In addition, transgenic plants overexpressing OsCYP21-4 exhibited increased tolerance to salinity and hydrogen peroxide treatment, along with increased peroxidase activity. These results demonstrate that OsCYP21-4 is a novel Golgi-localized cyclophilin that plays a role in oxidative stress tolerance, possibly by regulating peroxidase activity.

  16. 8 CFR 214.12 - Preliminary enrollment of schools in the Student and Exchange Visitor Information System (SEVIS).

    2010-01-01

    ... Student and Exchange Visitor Information System (SEVIS). 214.12 Section 214.12 Aliens and Nationality... of schools in the Student and Exchange Visitor Information System (SEVIS). (a) Private elementary and... schools are eligible for preliminary enrollment in Student and Exchange Visitor Information System...

  17. 47 CFR 36.214 - Long distance message revenue-Account 5100.

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Long distance message revenue-Account 5100. 36... PROPERTY COSTS, REVENUES, EXPENSES, TAXES AND RESERVES FOR TELECOMMUNICATIONS COMPANIES 1 Operating Revenues and Certain Income Accounts Operating Revenues § 36.214 Long distance message revenue—Account...

  18. 47 CFR 63.09 - Definitions applicable to international Section 214 authorizations.

    2010-10-01

    ... alliance) affecting the provision or marketing of international basic telecommunications services in the... 47 Telecommunication 3 2010-10-01 2010-10-01 false Definitions applicable to international Section... Extensions and Supplements § 63.09 Definitions applicable to international Section 214 authorizations....

  19. 22 CFR 214.38 - Submission of reports to the Library of Congress.

    2010-04-01

    ... MANAGEMENT Operation of Advisory Committees § 214.38 Submission of reports to the Library of Congress. (a) Each advisory committee is to file with the Library of Congress eight copies of each of its reports... Legislative Affairs for transmittal to the Library of Congress....

  20. The LMC HII region N 214C and its peculiar nebular blob

    Meynadier, F; Walborn, N; Meynadier, Frederic; Heydari-Malayeri, Mohammad; Walborn, Nolan

    2005-01-01

    We study the Large Magellanic Cloud HII region N 214C using imaging and spectroscopy obtained at the ESO New Technology Telescope. On the basis of the highest resolution images so far obtained of the OB association LH 110, we show that the main exciting source of the HII region, Sk -71 51, is in fact a tight cluster of massive stars consisting of at least 6 components in an area ~ 4" wide. Spectroscopic observations allow us to revise the spectral type of the main component (# 17) to O2 V ((f*)) + OB, a very rare, hot type. We also classify several other stars associated with N 214C and study the extinction and excitation characteristics of the HII region. Moreover, we obtain BVR photometry and astrometry of 2365 stars and from the corresponding color-magnitude diagram study the stellar content of N 214C and the surrounding LH 110. Furthermore, we discover a striking compact blob of ionized gas in the outer northern part of N 214C. A spherical structure of ~ 5" in radius (~ 1.3 pc), it is split into two lobes...

  1. 23 CFR 972.214 - Federal lands congestion management system (CMS).

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Federal lands congestion management system (CMS). 972... LANDS HIGHWAYS FISH AND WILDLIFE SERVICE MANAGEMENT SYSTEMS Fish and Wildlife Service Management Systems § 972.214 Federal lands congestion management system (CMS). (a) For purposes of this section,...

  2. 23 CFR 971.214 - Federal lands congestion management system (CMS).

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Federal lands congestion management system (CMS). 971... LANDS HIGHWAYS FOREST SERVICE MANAGEMENT SYSTEMS Forest Highway Program Management Systems § 971.214 Federal lands congestion management system (CMS). (a) For purposes of this section, congestion means...

  3. 23 CFR 970.214 - Federal lands congestion management system (CMS).

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Federal lands congestion management system (CMS). 970....214 Federal lands congestion management system (CMS). (a) For purposes of this section, congestion... modes. (2) For portions of the NPS transportation system within transportation management areas...

  4. 13 CFR 120.214 - What conditions apply for variable interest rates?

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What conditions apply for variable....214 What conditions apply for variable interest rates? A Lender may use a variable rate of interest... received the loan application. SBA shall approve the use of a variable interest rate under the...

  5. Half-life of 214Po and 212Po measured with CTF at LNGS

    Polonium isotopes 214Po and 212Po are part of the 238U and 232Th decay chains, respectively. There exist only a few measurements of these two mean lifetimes with precision better than one or two percent. Since we have been studying decay spectra of 214Bi and 212Bi with the purpose of experimentally constraining anti-neutrino spectral shape important for geoneutrino studies, we have a large statistics of decays of 214Po and 212Po collected with the Counting Test Facility (CTF), which was operational in the underground I.N.F.N. Gran Sasso National Laboratory. The apparatus consisted of an external cylindrical water tank (diameter ∼ 11 m, high ∼ 10 m; ∼ 1000 tons of water) serving as passive shielding for 4.8 m3 of liquid organic scintillator contained in an inner spherical vessel with a diameter of ∼ 2 m. The inner vessel was realized with a nylon membrane (∼ 500 ?m thick), with excellent optical clarity, which allowed the effective transmission of the scintillation light to the 100 phototubes (PMTs) forming the optical read-out, anchored on a 7 m diameter support structure inside the water tank. The high purity and low background in CTF allows a favourable signal to background ratio for these measurements. More specifically the ratio of signal to background of the present measurements is more than three orders of magnitude larger than the best existing measurements. We have studied the decays of 214Po into 210Pb and of 212Po into 208Pb tagged by the coincidence with the previously decays from 214Bi and 212Bi by using 222Rn, 232Th and 220Rn sources sealed inside quartz vials and inserted in the CTF

  6. miR-214 protects erythroid cells against oxidative stress by targeting ATF4 and EZH2.

    Gao, Ming; Liu, Yun; Chen, Yue; Yin, Chunyang; Chen, Jane-Jane; Liu, Sijin

    2016-03-01

    Nuclear factor (erythroid-derived 2) like 2 (Nrf2) is a key regulator in protecting cells against stress by targeting many anti-stress response genes. Recent evidence also reveals that Nrf2 functions partially by targeting mircroRNAs (miRNAs). However, the understanding of Nrf2-mediated cytoprotection through miRNA-dependent mechanisms is largely unknown. In the current study, we identified a direct Nrf2 targeting miRNA, miR-214, and demonstrated a protective role of miR-214 in erythroid cells against oxidative stresses generated by radiation, excess iron and arsenic (As) exposure. miR-214 expression was transcriptionally repressed by Nrf2 through a canonical antioxidant response element (ARE) within its promoter region, and this repression is ROS-dependence. The suppression of miR-214 by Nrf2 could antagonize oxidative stress-induced cell death in erythroid cells by two ways. First, miR-214 directly targeted ATF4, a crucial transcriptional factor involved in anti-stress responses, down regulation of miR-214 releases the repression of ATF4 translation and leads to increased ATF4 protein content. Second, miR-214 was able to prevent cell death by targeting EZH2, the catalytic core component of PRC2 complex that is responsible for tri-methylation reaction at lysine 27 (K27) of histone 3 (H3) (H3K27me3), by which As-induced miR-214 reduction resulted in an increased global H3K27me3 level and a compromised overexpression of a pro-apoptotic gene Bim. These two pathways downstream of miR-214 synergistically cooperated to antagonize erythroid cell death upon oxidative stress. Our combined data revealed a protective role of miR-214 signaling in erythroid cells against oxidative stress, and also shed new light on Nrf2-mediated cytoprotective machinery. PMID:26791102

  7. True coincidence summing correction determination for 214Bi principal gamma lines in NORM samples

    The gamma lines 609.3 and 1,120.3 keV are two of the most intensive γ emissions of 214Bi, but they have serious true coincidence summing (TCS) effects due to the complex decay schemes with multi-cascading transitions. TCS effects cause inaccurate count rate and hence erroneous results. A simple and easy experimental method for determination of TCS correction of 214Bi gamma lines was developed in this work using naturally occurring radioactive material samples. Height efficiency and self attenuation corrections were determined as well. The developed method has been formulated theoretically and validated experimentally. The corrections problems were solved simply with neither additional standard source nor simulation skills. (author)

  8. Transient-diffusion measurements of radon. Fick's law confirmation and 218Po/214Po behavior determination

    Usually, radon diffusion coefficients in soils are measured based on the assumption that Fick's law holds true. But, unlike in a free volume, strictly speaking, there is no guarantee that Fick's law holds in soils. Transient-diffusion measurements of radon in soils are best employed in order to confirm Fick's law. Alpha-particles from 218Po/214Po and from 222Rn cannot be distinguished in the course of those measurements. Therefore, the relevant portions of the detector reading must be allocated to each of these nuclides. For that purpose, the behaviors of 218Po and 214Po in the detection volume were determined and their ratios of contribution to the detector reading were also determined by Monte Carlo calculations and a verification test. This information was used to confirm Fick's law for representative Japanese sand and loam samples through indicial transient-diffusion measurements and a theoretical interpretation of the measured data. (author)

  9. Rapid photometry of supernova 1987A: a 2.14 ms pulsar?

    Middleditch, John; Kristian, Jerome A.; Kunkel, William E.; Hill, Kym M.; Watson, Robert D.; Lucinio, Richard; Imamura, James N.; Steiman-Cameron, Thomas Y.; Shearer, Andrew; Butler, Raymond; Redfern, Michael; Danks, Anthony C.

    2000-08-01

    We have monitored Supernova 1987A in optical/near-infrared bands using various high-speed photometers from a few weeks following its birth until early 1996 in order to search for a pulsar remnant. While we have found no clear evidence of any pulsar of constant intensity and stable timing, we have found emission with a complex period modulation near the frequency of 467.5 Hz - a 2.14 ms pulsar candidate. We first detected this signal in data taken on the remnant at the Las Campanas Observatory (LCO) 2.5-m Dupont telescope during 14-16 Feb. 1992 UT. We detected further signals near the 2.14 ms period on numerous occasions over the next four years in data taken with a variety of telescopes, data systems and detectors, at a number of ground- and space-based observatories. In particular, an effort during mid-1993 to monitor this signal with the U. of Tasmania 1-m telescope, when SN1987A was inaccessible to nearly all other observing sites due to high airmass, clearly detected the 2.14 ms signal in the first three nights' observations. The sequence of detections of this signal from Feb. `92 through August `93, prior to its apparent subsequent fading, is highly improbable (analysis techniques necessary for detection, it is difficult to determine the overall probability that all aspects of the signal are real, though it has remained consistent with an astrophysical origin throughout the several year timespan of our study.

  10. Comparison of adsorptions by rice hull and Lewatit TP 214 of platinum in chloride solution

    Morcali M.H.

    2013-01-01

    Full Text Available Rice hull, a biomass waste product, and Lewatit TP 214, a thiosemicarbazide sorbent, were investigated as adsorbents for the adsorption of platinum (IV ions from synthetically prepared dilute chloroplatinic acid solutions. The rice hull was characterized by Attenuated Total Reflection-Fourier transform infrared spectroscopy (ATR-FTIR. The effects of the different adsorption parameters, sorbent dosage, contact time, temperature and pH of solution on adsorption percentage were studied in detail on a batch sorption. The adsorption equilibrium data were best fitted with the Langmuir isotherm model. The maximum monolayer adsorption capacities, Qmax, at 25°C were found to be 42.02 and 33.22 mg g-1 for the rice hull and Lewatit TP 214, respectively. Thermodynamic calculations using the measured ΔH°, ΔS° and ΔG° values indicate that the adsorption process was spontaneous and exothermic. The pseudo-first-order and pseudo-second-order rate equations were investigated; the adsorption of platinum ions for both sorbents was found to be described by the pseudo-second-order kinetic model. The kinetic rate, k2, using 30 mg sorbent at 25°C was found to be 0.0289 and 0.0039 g min-1 mg-1 for the rice hull and Lewatit TP 214, respectively. The results indicated that the rice hull can be effectively used for the removal of platinum from aqueous solution.

  11. 49 CFR 214.511 - Required audible warning devices for new on-track roadway maintenance machines.

    2010-10-01

    ... SAFETY On-Track Roadway Maintenance Machines and Hi-Rail Vehicles § 214.511 Required audible warning...) An automatic change-of-direction alarm which provides an audible signal that is at least...

  12. Degradation of Triazine-2-14C Metsulfuron–Methyl in Soil from an Oil Palm Plantation

    Ismail, B. S.; O K Eng; M A Tayeb

    2015-01-01

    Triazine-2-(14)C metsulfuron-methyl is a selective, systemic sulfonylurea herbicide. Degradation studies in soils are essential for the evaluation of the persistence of pesticides and their breakdown products. The purpose of the present study was to investigate the degradation of triazine-2-(14)C metsulfuron-methyl in soil under laboratory conditions. A High Performance Liquid Chromatograph (HPLC) equipped with an UV detector and an on-line radio-chemical detector, plus a Supelco Discovery co...

  13. Educational experiment for students using natural radioactivity. 1. Radiochemical analysis of 214Bi in Ena and Ikeda mineral spring water

    A couple of educational experiments have been developed using natural radioactivity contained in mineral spring water and a small GM counter. These experiments are safe and inexpensive enough to be conducted at high school or university, nevertheless they are quantitative enough for learners to observe half-life of 214Pb and 214Bi, and to help them understand the concept of radioactive equilibrium between them. (author)

  14. MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway

    Ahmed, Mohammed I.; Alam, Majid; Emelianov, Vladimir U.; Poterlowicz, Krzysztof; Patel, Ankit; Sharov, Andrey A.; Mardaryev, Andrei N.; Botchkareva, Natalia V.

    2014-01-01

    Skin development is governed by complex programs of gene activation and silencing, including microRNA-dependent modulation of gene expression. Here, we show that miR-214 regulates skin morphogenesis and hair follicle (HF) cycling by targeting β-catenin, a key component of the Wnt signaling pathway. miR-214 exhibits differential expression patterns in the skin epithelium, and its inducible overexpression in keratinocytes inhibited proliferation, which resulted in formation of fewer HFs with de...

  15. Leukemia-Associated Nup214 Fusion Proteins Disturb the XPO1-Mediated Nuclear-Cytoplasmic Transport Pathway and Thereby the NF-κB Signaling Pathway.

    Saito, Shoko; Cigdem, Sadik; Okuwaki, Mitsuru; Nagata, Kyosuke

    2016-07-01

    Nuclear-cytoplasmic transport through nuclear pore complexes is mediated by nuclear transport receptors. Previous reports have suggested that aberrant nuclear-cytoplasmic transport due to mutations or overexpression of nuclear pore complexes and nuclear transport receptors is closely linked to diseases. Nup214, a component of nuclear pore complexes, has been found as chimeric fusion proteins in leukemia. Among various Nup214 fusion proteins, SET-Nup214 and DEK-Nup214 have been shown to be engaged in tumorigenesis, but their oncogenic mechanisms remain unclear. In this study, we examined the functions of the Nup214 fusion proteins by focusing on their effects on nuclear-cytoplasmic transport. We found that SET-Nup214 and DEK-Nup214 interact with exportin-1 (XPO1)/CRM1 and nuclear RNA export factor 1 (NXF1)/TAP, which mediate leucine-rich nuclear export signal (NES)-dependent protein export and mRNA export, respectively. SET-Nup214 and DEK-Nup214 decreased the XPO1-mediated nuclear export of NES proteins such as cyclin B and proteins involved in the NF-κB signaling pathway by tethering XPO1 onto nuclear dots where Nup214 fusion proteins are localized. We also demonstrated that SET-Nup214 and DEK-Nup214 expression inhibited NF-κB-mediated transcription by abnormal tethering of the complex containing p65 and its inhibitor, IκB, in the nucleus. These results suggest that SET-Nup214 and DEK-Nup214 perturb the regulation of gene expression through alteration of the nuclear-cytoplasmic transport system. PMID:27114368

  16. 44Sc-DOTA-BN[2-14]NH2 in comparison to 68Ga-DOTA-BN[2-14]NH2 in pre-clinical investigation. Is 44Sc a potential radionuclide for PET?

    Aim: In the present study we demonstrate the in vitro and in vivo comparison of the 44Sc and 68Ga labeled DOTA-BN[2-14]NH2. 44Sc is a positron emitter with a half life of 3.92 h. Hence it could be used for PET imaging with ligands requiring longer observation time than in the case of 68Ga. Methods: The binding affinity of natSc-DOTA-BN[2-14]NH2 and natGa-DOTA-BN[2-14]NH2 to GRP receptors was studied in competition to [125I-Tyr4]-Bombesin in the human prostate cancer cell line PC-3. A preliminary biodistribution in normal rats was performed, while first microPET images were assessed in male Copenhagen rats bearing the androgen-independent Dunning R-3327-AT-1 prostate cancer tumor. Results: The affinity to GRP receptors in the PC-3 cell line was higher for natGa-DOTA-BN[2-14]NH2 (IC50(nM)=0.85±0.06) than that of natSc-DOTA-BN[2-14]NH2 (IC50 (nM)=6.49±0.13). The internalization rate of 68Ga labeled DOTA-BN[2-14]NH2 was slower than that of 44Sc, but their final internalization percents were comparable. 68Ga-DOTA-BN[2-14]NH2 was externalized faster than 44Sc-DOTA-BN[2-14]NH2. The biodistribution of 44Sc-DOTA-BN[2-14]NH2 and 68Ga-DOTA-BN[2-14]NH2 in normal rats revealed a higher uptake in target organs and tissues of the first one while both excreted mainly through urinary tract. In microPET images both tracers were accumulated in the tumor with similar uptake patterns. Conclusions: Despite the differences in the receptor affinity both the 68Ga- and the 44Sc-labeled DOTA-BN[2-14]NH2 tracers showed comparable distribution and similar time constants of uptake and elimination. Moreover no differences in tumor accumulation (neither in the overall uptake nor in the dynamics) were observed from the microPet imaging. From that perspective the use of either 44Sc or 68Ga for detecting tumors with GRP receptors is equivalent. - Highlights: ► In vitro and in vivo evaluation of 44Sc- and 68Ga-DOTA-BN[2-14]NH2 in reference to published data. ► Higher in vitro affinity to GRP

  17. Work in the area of buildings 513 - 289 - 214 - Disruption to traffic

    Optical Fibre Section, TS/EL

    2005-01-01

    The TS/EL group wishes to inform you that, in order to create an optical fibre access for the GEANT2 project, Route Rutherford will be closed to the public between Buildings 289 and 214 on 13 July 2005. Part of the Sophora car park will also be closed while the work is in progress (week 28: 11 - 15 July). You are requested to comply with the road signs in place. For more information, please call 160484. Optical Fibre Section, TS/EL

  18. MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway.

    Ahmed, Mohammed I; Alam, Majid; Emelianov, Vladimir U; Poterlowicz, Krzysztof; Patel, Ankit; Sharov, Andrey A; Mardaryev, Andrei N; Botchkareva, Natalia V

    2014-11-24

    Skin development is governed by complex programs of gene activation and silencing, including microRNA-dependent modulation of gene expression. Here, we show that miR-214 regulates skin morphogenesis and hair follicle (HF) cycling by targeting β-catenin, a key component of the Wnt signaling pathway. miR-214 exhibits differential expression patterns in the skin epithelium, and its inducible overexpression in keratinocytes inhibited proliferation, which resulted in formation of fewer HFs with decreased hair bulb size and thinner hair production. The inhibitory effects of miR-214 on HF development and cycling were associated with altered activities of multiple signaling pathways, including decreased expression of key Wnt signaling mediators β-catenin and Lef-1, and were rescued by treatment with pharmacological Wnt activators. Finally, we identify β-catenin as one of the conserved miR-214 targets in keratinocytes. These data provide an important foundation for further analyses of miR-214 as a key regulator of Wnt pathway activity and stem cell functions during normal tissue homeostasis, regeneration, and aging. PMID:25422376

  19. Evaluation of radium-226 body burden by in vivo measurement of bismuth-214

    An indirect method of estimation of radium-226 body burden has been developed to overcome the difficulties of direct measurement of radium on account of low emission of 186 KeV gamma radiation that too in a region where the background count rate is high. The method is based on in vivo measurement of sup(214)Bi content of the body by a shadow shield whole body counter [102 mm (dia) x 76 mm (thick) NaI(Tl) detector]. sup(214)Bi emits gamma rays of 0.609, 1.120 and 1.764 MeV of which the last one is suitable for whole body counting because in that energy region there is no contribution from naturally occurring radioisotopes in the body (e.g. sup(40)K) and the response is independent of variation in body build. The ratio of the minimum detectable radium body burden for the whole body monitor at Jaduguda uranium mines using the indirect and direct methods for the same counting periods works out to be 0.85, indicating that the indirect method is somewhat superior to the direct method. (M.G.B.)

  20. miR-214 promotes apoptosis and sensitizes breast cancer cells to doxorubicin by targeting the RFWD2-p53 cascade.

    Zhang, Jiaxuan; Su, Beibei; Gong, Chen; Xi, Qingsongg; Chao, Tengfei

    2016-09-01

    miR-214 is involved in numerous physiological and pathological processes including tumorigenesis. However, the function of miR-214 in the development and treatment of breast cancer remains elusive. In this study, we report that miR-214 is strikingly down-regulated in breast cancer cell lines and clinical samples, particularly, in the doxorubicin resistant tumor tissues. Remarkably, restoration of miR-214 expression induces apoptosis and sensitizes the MCF7 cells sustaining wild-type p53, but not the p53 null MDA-MB-157 cells, to doxorubicin. Furthermore, we reveal that miR-214 directly down-regulates the expression of RFWD2, also known as COP1, an E3 ligase targeting the tumor suppressor p53 for proteasomal degradation. In addition, RFWD2 protein levels are reversely correlated with miR-214 expression levels in breast cancer tissues. Moreover, ectopic expression of RFWD2 markedly abolishes miR-214-triggered apoptosis of MCF7 cells. In conclusion, miR-214 functions as a tumor suppressor by regulating the RFWD2-p53 cascade, thus delivery of miR-214 analogs could be a potential adjunct therapy in breast cancer harboring wild type p53. PMID:27422604

  1. Nuclear distributions of NUP62 and NUP214 suggest architectural diversity and spatial patterning among nuclear pore complexes.

    Yayoi Kinoshita

    Full Text Available The shape of nuclei in many adherent cultured cells approximates an oblate ellipsoid, with contralateral flattened surfaces facing the culture plate or the medium. Observations of cultured cell nuclei from orthogonal perspectives revealed that nucleoporin p62 (NUP62 and nucleoporin 214 (NUP214 are differentially distributed between nuclear pore complexes on the flattened surfaces and peripheral rim of the nucleus. High resolution stimulated emission depletion (STED immunofluorescence microscopy resolved individual NPCs, and suggested both heterogeneity and microheterogeneity in NUP62 and NUP214 immunolabeling among in NPC populations. Similar to nuclear domains and interphase chromosome territories, architectural diversity and spatial patterning of NPCs may be an intrinsic property of the nucleus that is linked to the functions and organization of underlying chromatin.

  2. Forced expression of the DEK-NUP214 fusion protein promotes proliferation dependent on upregulation of mTOR

    The t(6;9)(p23;q34) chromosomal translocation is found in 1% of acute myeloid leukemia and encodes the fusion protein DEK-NUP214 (formerly DEK-CAN) with largely uncharacterized functions. We expressed DEK-NUP214 in the myeloid cell lines U937 and PL-21 and studied the effects on cellular functions. In this study, we demonstrate that expression of DEK-NUP214 increases cellular proliferation. Western blot analysis revealed elevated levels of one of the key proteins regulating proliferation, the mechanistic target of rapamycin, mTOR. This conferred increased mTORC1 but not mTORC2 activity, as determined by the phosphorylation of their substrates, p70 S6 kinase and Akt. The functional importance of the mTOR upregulation was determined by assaying the downstream cellular processes; protein synthesis and glucose metabolism. A global translation assay revealed a substantial increase in the translation rate and a metabolic assay detected a shift from glycolysis to oxidative phosphorylation, as determined by a reduction in lactate production without a concomitant decrease in glucose consumption. Both these effects are in concordance with increased mTORC1 activity. Treatment with the mTORC1 inhibitor everolimus (RAD001) selectively reversed the DEK-NUP214-induced proliferation, demonstrating that the effect is mTOR-dependent. Our study shows that the DEK-NUP214 fusion gene increases proliferation by upregulation of mTOR, suggesting that patients with leukemias carrying DEK-NUP214 may benefit from treatment with mTOR inhibitors

  3. "Sit u hier maar gaan staan jy daar": Kantaantekeninge by Jakobus 2:1-4

    Jan van der Watt

    2001-01-01

    "You may sit here, but you must stand there" -On James 2:1-4 The question is what the speaker in James 2:2-3. Intended when he said that the rich man may sit "here" on a good place, but that the poor man must stand over "there" or may sit "under" his footstool. It is argued that this episode should be located within a larger ancient house which was used as a gathering place for the Christian community. The poor man is asked to stand in the courtyard or may sit on the ground in  the sittingroo...

  4. Thermodynamic Critical Field and Superconducting Fluctuation of Vortices for High Temperature Cuprate Superconductor: La-214

    Thermodynamics has been studied systematically for the high temperature cuprate superconductor La2-xSrxCuO4-δ, La-214, in the entire superconductive region from strongly underdoped to strongly overdoped regimes. Magnetization studies with H (parallel) c have been made in order to investigate the changes in free energy of the system as the number of carriers is reduced. Above the superconducting transition temperature, the normal-state magnetization exhibits a two-dimensional Heisenberg antiferromagnetic behavior. Below Tc, magnetization data are thermodynamically reversible over large portions of the H-T plane, so the free energy is well defined in these regions. As the Sr concentration is varied over the wide range from 0.060 (strongly underdoped) to 0.234 (strongly overdoped), the free energy change goes through a maximum at the optimum doped in a manner similar to the Tc0 vs. x curve. The density of states, N(0), remains nearly constant in the overdoped and optimum doped regimes, taking a broad maximum around x = 0.188, and then drops abruptly towards zero in the underdoped regime. The La2-xSrxCuO4 (La-214) system displays the fluctuating vortex behavior with the characteristic of either 2D or 3D fluctuations as indicated by clearly identifiable crossing points T* close to Tc. The dimensional character of the fluctuations depends on both applied magnetic fields and the density of charge carriers. The dimensional crossover from 2D to 3D occurs in the strongly underdoped regime when the c-axis coherence distance ξc becomes comparable to the spacing between adjacent CuO2 layers s at sufficiently high magnetic field near Hc2

  5. Thermodynamic Critical Field and Superconducting Fluctuation of Vortices for High Temperature Cuprate Superconductor: La-214

    Douglas K. Finnemore

    2001-06-25

    Thermodynamics has been studied systematically for the high temperature cuprate superconductor La{sub 2-x}Sr{sub x}CuO{sub 4-{delta}}, La-214, in the entire superconductive region from strongly underdoped to strongly overdoped regimes. Magnetization studies with H {parallel} c have been made in order to investigate the changes in free energy of the system as the number of carriers is reduced. Above the superconducting transition temperature, the normal-state magnetization exhibits a two-dimensional Heisenberg antiferromagnetic behavior. Below T{sub c}, magnetization data are thermodynamically reversible over large portions of the H-T plane, so the free energy is well defined in these regions. As the Sr concentration is varied over the wide range from 0.060 (strongly underdoped) to 0.234 (strongly overdoped), the free energy change goes through a maximum at the optimum doped in a manner similar to the T{sub c0} vs. x curve. The density of states, N(0), remains nearly constant in the overdoped and optimum doped regimes, taking a broad maximum around x = 0.188, and then drops abruptly towards zero in the underdoped regime. The La{sub 2-x}Sr{sub x}CuO{sub 4} (La-214) system displays the fluctuating vortex behavior with the characteristic of either 2D or 3D fluctuations as indicated by clearly identifiable crossing points T* close to T{sub c}. The dimensional character of the fluctuations depends on both applied magnetic fields and the density of charge carriers. The dimensional crossover from 2D to 3D occurs in the strongly underdoped regime when the c-axis coherence distance {xi}{sub c} becomes comparable to the spacing between adjacent CuO{sub 2} layers s at sufficiently high magnetic field near H{sub c2}.

  6. Thermodynamic Critical Field and Superconducting Fluctuation of Vortices for High Temperature Cuprate Superconductor: La-214

    Yung Moo Huh

    2001-05-01

    Thermodynamics has been studied systematically for the high temperature cuprate superconductor La{sub 2-x}Sr{sub x}CuO{sub 4-{delta}}, La-214, in the entire superconductive region from strongly underdoped to strongly overdoped regimes. Magnetization studies with H{parallel}c have been made in order to investigate the changes in free energy of the system as the number of carriers is reduced. Above the superconducting transition temperature, the normal-state magnetization exhibits a two-dimensional Heisenberg antiferromagnetic behavior. Below T{sub c}, magnetization data are thermodynamically reversible over large portions of the H-T plane, so the free energy is well defined in these regions. As the Sr concentration is varied over the wide range from 0.060 (strongly underdoped) to 0.234 (strongly overdoped), the free energy change goes through a maximum at the optimum doped in a manner similar to the T{sub c0} vs. x curve. The density of states, N(0), remains nearly constant in the overdoped and optimum doped regimes, taking a broad maximum around x = 0.188, and then drops abruptly towards zero in the underdoped regime. The La{sub 2-x}Sr{sub x}CuO{sub 4} (La-214) system displays the fluctuating vortex behavior with the characteristic of either 2D or 3D fluctuations as indicated by clearly identifiable crossing points T* close to T{sub c}. The dimensional character of the fluctuations depends on both applied magnetic fields and the density of charge carriers. The dimensional crossover from 2D to 3D occurs in the strongly underdoped regime when the c-axis coherence distance {zeta}{sub c} becomes comparable to the spacing between adjacent CuO{sub 2} layers s at sufficiently high magnetic fields near H{sub c2}.

  7. Solution structure and dynamics of the I214V mutant of the rabbit prion protein.

    Yi Wen

    Full Text Available BACKGROUND: The conformational conversion of the host-derived cellular prion protein (PrP(C into the disease-associated scrapie isoform (PrP(Sc is responsible for the pathogenesis of transmissible spongiform encephalopathies (TSEs. Various single-point mutations in PrP(Cs could cause structural changes and thereby distinctly influence the conformational conversion. Elucidation of the differences between the wild-type rabbit PrP(C (RaPrP(C and various mutants would be of great help to understand the ability of RaPrP(C to be resistant to TSE agents. METHODOLOGY/PRINCIPAL FINDINGS: We determined the solution structure of the I214V mutant of RaPrP(C(91-228 and detected the backbone dynamics of its structured C-terminal domain (121-228. The I214V mutant displays a visible shift of surface charge distribution that may have a potential effect on the binding specificity and affinity with other chaperones. The number of hydrogen bonds declines dramatically. Urea-induced transition experiments reveal an obvious decrease in the conformational stability. Furthermore, the NMR dynamics analysis discloses a significant increase in the backbone flexibility on the pico- to nanosecond time scale, indicative of lower energy barrier for structural rearrangement. CONCLUSIONS/SIGNIFICANCE: Our results suggest that both the surface charge distribution and the intrinsic backbone flexibility greatly contribute to species barriers for the transmission of TSEs, and thereby provide valuable hints for understanding the inability of the conformational conversion for RaPrP(C.

  8. 49 CFR 214.353 - Training and qualification of roadway workers who provide on-track safety for roadway work groups.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Training and qualification of roadway workers who provide on-track safety for roadway work groups. 214.353 Section 214.353 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway...

  9. 20 CFR 30.214 - How does a claimant establish that the employee is a member of the Special Exposure Cohort?

    2010-04-01

    ... employee is a member of the Special Exposure Cohort? 30.214 Section 30.214 Employees' Benefits OFFICE OF... a member of the Special Exposure Cohort? (a) For purposes of establishing eligibility as a member of the Special Exposure Cohort (SEC) under § 30.210(a)(1), the employee must have been a DOE employee,...

  10. Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export.

    Port, Sarah A; Monecke, Thomas; Dickmanns, Achim; Spillner, Christiane; Hofele, Romina; Urlaub, Henning; Ficner, Ralf; Kehlenbach, Ralph H

    2015-10-27

    CRM1 is the major nuclear export receptor. During translocation through the nuclear pore, transport complexes transiently interact with phenylalanine-glycine (FG) repeats of multiple nucleoporins. On the cytoplasmic side of the nuclear pore, CRM1 tightly interacts with the nucleoporin Nup214. Here, we present the crystal structure of a 117-amino-acid FG-repeat-containing fragment of Nup214, in complex with CRM1, Snurportin 1, and RanGTP at 2.85 Å resolution. The structure reveals eight binding sites for Nup214 FG motifs on CRM1, with intervening stretches that are loosely attached to the transport receptor. Nup214 binds to N- and C-terminal regions of CRM1, thereby clamping CRM1 in a closed conformation and stabilizing the export complex. The role of conserved hydrophobic pockets for the recognition of FG motifs was analyzed in biochemical and cell-based assays. Comparative studies with RanBP3 and Nup62 shed light on specificities of CRM1-nucleoporin binding, which serves as a paradigm for transport receptor-nucleoporin interactions. PMID:26489467

  11. 49 CFR 214.519 - Floors, decks, stairs, and ladders of on-track roadway maintenance machines.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Floors, decks, stairs, and ladders of on-track... SAFETY On-Track Roadway Maintenance Machines and Hi-Rail Vehicles § 214.519 Floors, decks, stairs, and ladders of on-track roadway maintenance machines. Floors, decks, stairs, and ladders of on-track...

  12. 49 CFR 214.521 - Flagging equipment for on-track roadway maintenance machines and hi-rail vehicles.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Flagging equipment for on-track roadway... WORKPLACE SAFETY On-Track Roadway Maintenance Machines and Hi-Rail Vehicles § 214.521 Flagging equipment for... and hi-rail vehicle shall have on board a flagging kit that complies with the operating rules of...

  13. 30 CFR 250.214 - What geological and geophysical (G&G) information must accompany the EP?

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What geological and geophysical (G&G... and Information Contents of Exploration Plans (ep) § 250.214 What geological and geophysical (G&G) information must accompany the EP? The following G&G information must accompany your EP: (a)...

  14. SCN1Bb R214Q found in 3 patients: 1 with Brugada syndrome and 2 with lone atrial fibrillation

    Olesen, Morten S; Holst, Anders G; Haunsø, Stig;

    2012-01-01

    BACKGROUND: SCN1Bb encodes the ß-subunit of the sodium channel. A mutation in SCN1Bb R214Q has recently been shown both to increase the Kv4.3 current and to decrease the sodium current. The variant was suggested to increase the susceptibility to Brugada syndrome (BrS). OBJECTIVE: To sequence a...

  15. 20 CFR 416.214 - You are disabled and drug addiction or alcoholism is a contributing factor material to the...

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false You are disabled and drug addiction or....214 You are disabled and drug addiction or alcoholism is a contributing factor material to the... because you are disabled and drug addiction or alcoholism is a contributing factor material to...

  16. Classification of hypothalamic hamartoma according to the clinical manifestations of 214 cases%214例下丘脑错构瘤分型与临床症状

    罗世琪; 李春德; 马振宇; 张玉琪; 甲戈

    2009-01-01

    Objective To study the relationship between the topology and clinical manifestations of hypothalamic hamartoma(HH). Method A retrospective review of 214 patients with HH was performed between August 1994 and May 2008. Statistical analysis were performed using SPSS version 13 and statistical significance was judged to be present at probability values of less than 0.05. A new classification of HH was developed based on topographical and clinical data. Results The HH were diagnosed and divided into four categories( type Ⅰ~Ⅳ) based on MR imaging findings focused on the relationship between HH and hypothalamus or the third ventricle. Type Ⅰ and type Ⅱ defined as HH attached to the floor of third ventricle with a narrow(type Ⅰ) or broad(type Ⅱ) interfaces, type Ⅲ (straddling type) defined as the hamartoma located partially within the hypothalamus and the third ventricle. Type Ⅳ as the HH located totally within the third ventricle. There were 77(36.0%) cases of HH belonging to the type Ⅰ,26(12.1%) cases to the type Ⅱ,87(40.7%) cases to the type Ⅲ and 24(11.2%) cases to the type Ⅳ.The mean age at onset of precocious puberty(PP) was significantly younger than that of epilepsy's. The maximum diameter of HH in type Ⅰ is 13.57 mm,in type Ⅱ is 18.73 ram,in type Ⅲ is 22.08 mm and 11.21 mm in type Ⅳ. The diameter of HH presented with epilepsy is larger than that of HH without epilepsy. The percentage of PP in type Ⅰ to Ⅳ is 54. 8%, 10. 4% ,33.0% and 1.7%, respectively,and PP was mostly common in type Ⅰ and rare in type Ⅳ. The percentage of gelastic seizure in type Ⅰ to Ⅳ is 3.1%, 7.3%, 66.7% and 22.9%, respectively. Gelastic seizures and epilepsy are mostly presented in type Ⅲ and rarely in type Ⅰ. The percentage of asymptomatic HH(14 cases) in the four type is varied as 50%, 35.7%, 7.1% and 7.1%. Conclusions The clinical manifestation is correlated with the topology of HH in relation to the hypothalamus and this correlation is

  17. Impact of HIV-1 reverse transcriptase polymorphism F214L on virological response to thymidine analogue-based regimens in antiretroviral therapy (ART)-naive and ART-experienced patients

    Ceccherini-Silberstein, Francesca; Cozzi-Lepri, Alessandro; Ruiz, Lidia;

    2007-01-01

    A negative association between the polymorphism F214L and type 1 thymidine analogue (TA) mutations (TAMs) has been observed. However, the virological response to TAs according to the detection of F214L has not been evaluated.......A negative association between the polymorphism F214L and type 1 thymidine analogue (TA) mutations (TAMs) has been observed. However, the virological response to TAs according to the detection of F214L has not been evaluated....

  18. Monotonic and cyclic stress-strain response of annealed 21/4Cr--1Mo steel

    The stress-strain response of isothermally annealed 21/4 Cr-1 Mo steel under monotonic and cyclic loadings has been characterized at temperatures from 21 to 5930C (70 to 11000F). Monotonic stress-strain curves were developed for uniaxial tensile loading of specimens at strain rates of 8.33 x 10-5 and 8.33 x 10-6 sec-1 (0.005 and 0.0005 min-1). The cyclic stress-strain response was measured for the first 100 fully reversed strain cycles at strain ranges between 0.4 and 3.0 percent under uniaxial loading at a strain rate of 8.33 x 10-5 sec-1. The effects of creep, stress-relaxation, and thermal-exposure hold periods on the cyclic stress-strain behavior were also investigated at 5100C (9500F). Monotonic stress-strain curves were quantified using a power law relation between stress range and plastic-strain range (a range equals twice the amplitude). Cyclic hardening was observed at temperatures up to 4270C (8000F). A mixture of initial cyclic hardening followed by later cyclic softening was seen at temperatures from 482 to 5380C (900 to 10000F), and cyclic softening was observed at 5930C (11000F). For the strain ranges investigated, the cyclic stress-strain response was analyzed in terms of the ascending path of the stress-strain hysteresis loop for the tenth cycle. These cyclic stress-strain paths were approximated by a translation of the monotonic curve along the elastic modulus line. This empirical model then provides a representation of the monotonic and cyclic stress-strain response of this alloy over a wide range of temperatures and in a form consistent with the constitutive equations presently recommended for use in inelastic design analysis of stainless steel nuclear components. The reported results form part of the data base being used by ORNL in formulating similar general inelastic constitutive equations for analysis of 21/4 Cr-1 Mo steel components

  19. Validation-based insertional mutagenesis for identification of Nup214 as a host factor for EV71 replication in RD cells

    Highlights: •We introduced a new mutagenesis strategy named VBIM to the viral research. •This method can identify either host factors or host restriction factors. •Using VBIM system, we identified Nup214 as a host factor for EV71 replication in RD cells. -- Abstract: Lentiviral validation-based insertional mutagenesis (VBIM) is a sophisticated, forward genetic approach that is used for the investigation of signal transduction in mammalian cells. Using VBIM, we conducted function-based genetic screening for host genes that affect enterovirus 71 (EV71) viral replication. This included host factors that are required for the life cycle of EV71 and host restriction factors that inhibit EV71 replication. Several cell clones, resistant to EV71, were produced using EV71 infection as a selection pressure and the nuclear pore protein 214 (Nup214) was identified as a host factor required for EV71 replication. In SD2-2, the corresponding VBIM lentivirus transformed clone, the expression of endogenous Nup214 was significantly down-regulated by the reverse inserted VBIM promoter. After Cre recombinase-mediated excision of the VBIM promoter, the expression of Nup214 recovered and the clone regained sensitivity to the EV71 infection. Furthermore, over-expression of Nup214 in the cells suggested that Nup214 was promoting EV71 replication. Results of this study indicate that a successful mutagenesis strategy has been established for screening host genes related to viral replication

  20. Validation-based insertional mutagenesis for identification of Nup214 as a host factor for EV71 replication in RD cells

    Wang, Bei; Zhang, XiaoYu; Zhao, Zhendong, E-mail: timjszzd@163.com

    2013-08-02

    Highlights: •We introduced a new mutagenesis strategy named VBIM to the viral research. •This method can identify either host factors or host restriction factors. •Using VBIM system, we identified Nup214 as a host factor for EV71 replication in RD cells. -- Abstract: Lentiviral validation-based insertional mutagenesis (VBIM) is a sophisticated, forward genetic approach that is used for the investigation of signal transduction in mammalian cells. Using VBIM, we conducted function-based genetic screening for host genes that affect enterovirus 71 (EV71) viral replication. This included host factors that are required for the life cycle of EV71 and host restriction factors that inhibit EV71 replication. Several cell clones, resistant to EV71, were produced using EV71 infection as a selection pressure and the nuclear pore protein 214 (Nup214) was identified as a host factor required for EV71 replication. In SD2-2, the corresponding VBIM lentivirus transformed clone, the expression of endogenous Nup214 was significantly down-regulated by the reverse inserted VBIM promoter. After Cre recombinase-mediated excision of the VBIM promoter, the expression of Nup214 recovered and the clone regained sensitivity to the EV71 infection. Furthermore, over-expression of Nup214 in the cells suggested that Nup214 was promoting EV71 replication. Results of this study indicate that a successful mutagenesis strategy has been established for screening host genes related to viral replication.

  1. Upregulation of MicroRNA-214 Contributes to the Development of Vascular Remodeling in Hypoxia-induced Pulmonary Hypertension Via Targeting CCNL2

    Liu, HaiTao; Tao, Yin; Chen, Mai; Yu, Jin; Li, Wei-Jie; Tao, Ling; Li, Yan; Li, Fei

    2016-01-01

    Hypoxia-induced pulmonary hypertension (PH), which is characterized by vascular remodeling of blood vessels, is a significant complication of chronic obstructive pulmonary disease (COPD). In this study, we screened 13 candidate miRNAs in pulmonary artery smooth muscle cells (PASMCs) harvested from COPD patients with PH (n = 18) and normal controls (n = 15) and found that the expression of miR-214 was differentially expressed between these two groups. Additionally, cyclin L2 (CCNL2) was validated as a target of miR-214 in PASMCs using a luciferase assay. Based on real-time PCR, immunohistochemistry and western blot, the expression of CCNL2 was substantially downregulated in PASMCs from COPD patients with PH compared with those from normal controls. Moreover, the relationship between miRNA and mRNA expression was confirmed using real-time PCR and western blot in PASMCs transfected with miR-214 mimics. Furthermore, the introduction of miR-214 significantly promoted the proliferation of PASMCs by suppressing cell apoptosis, and this effect was mediated by the downregulation of CCNL2. Exposure of PASMCs to hypoxia significantly increased the expression of miR-214, decreased the expression of CCNL2, and promoted cell proliferation. However, these effects were significantly attenuated by the introduction of miR-214 inhibitors, which significantly downregulated miR-214 expression and upregulated CCNL2 expression. PMID:27381447

  2. Plastic deformation and fracture behaviour of 21/4 Cr-1 Mo pressure-vessel steel

    During the heat treatment of steel plates and forgings of large thicknesses, microstructures with various volume fractions of ferrite appear. Plastic properties and fracture behaviour of these mixed microstructures are a function of ferrite content. The influence of ferrite content in the range from 0% to 54% in the bainitic-ferritic microstructure on mechanical properties and fracture behaviour of 21/4 Cr-1 Mo steel was examined. The yield stress was found to decrease linearly with the volume fraction of ferrite. The tensile strength was independent of ferrite content up to 25%, after which the tensile strength decreased. Using the Charpy test it has been found that the critical ferrite content-25%-exists in a mixed microstructure, at which the propagation and initiation transition temperatures attain the highest values. The fracture toughness tests gave the same results. Increasing the volume fraction of ferrite, the cleavage fracture toughness/temperature curves were shifted to higher temperatures. Simultaneously, the ductile-brittle fracture toughness transition temperature was raised reaching the highest value for the critical ferrite content. The fracture behaviour could be tentatively explained through the influence of ferrite volume fraction on both the cleavage fracture stress and the stress level at the crack tip. (author)

  3. Thermodynamic Critical Field and Superconducting Fluctuation of Vortices for High Temperature Cuprate Superconductor La-214

    Yung Moo Hu

    2001-01-01

    charge carriers. The dimensional crossover from 2D to 3D occurs in the strongly underdoped regime when the c-axis coherence distance zeta sub c becomes comparable to the spacing between adjacent CuO sub 2 layers s at sufficiently high magnetic fields near H sub c sub 2. Thermodynamics has been studied systematically for the high temperature cuprate superconductor La sub 2 sub - sub x Sr sub x CuO sub 4 sub - subdelta, La-214, in the entire superconductive region from strongly underdoped to strongly overdoped regimes. Magnetization studies with H(parallel)c have been made in order to investigate the changes in free energy of the system as the number of carriers is reduced. Above the superconducting transition temperature, the normal-state magnetization exhibits a two-dimensional Heisenberg antiferromagnetic behavior. Below T sub c , magnetization data are thermodynamically reversible over large portions of the H-T plane, so the free energy is well defined in these regions. As the Sr concentration is varied ove...

  4. Mapping the Primate Visual System with [2-14C]Deoxyglucose

    Macko, Kathleen A.; Jarvis, Charlene D.; Kennedy, Charles; Miyaoka, Mikoto; Shinohara, Mami; Sokoloff, Louis; Mishkin, Mortimer

    1982-10-01

    The [2-14C]deoxyglucose method was used to identify the cerebral areas related to vision in the rhesus monkey (Macaca mulatta). This was achieved by comparing glucose utilization in a visually stimulated with that in a visually deafferented hemisphere. The cortical areas related to vision included the entire expanse of striate, prestriate, and inferior temporal cortex as far forward as the temporal pole, the posterior part of the inferior parietal lobule, and the prearcuate and inferior prefrontal cortex. Subcortically, in addition to the dorsal lateral geniculate nucleus and superficial layers of the superior colliculus, the structures related to vision included large parts of the pulvinar, caudate, putamen, claustrum, and amygdala. These results, which are consonant with a model of visual function that postulates an occipito-temporo-prefrontal pathway for object vision and an occipito-parieto-prefrontal pathway for spatial vision, reveal the full extent of those pathways and identify their points of contact with limbic, striatal, and diencephalic structures.

  5. Autoradiographic disposition of [1-methyl-14C]- and [2-14C]caffeine in mice

    Male, C57B1/6J mice received either [1-methyl-14C]caffeine or [2-14C]caffeine via the tail vein at a dose of 0.7 or 11 mg/kg, respectively. At 0.1, 0.33, 1, 3, 9, and 24 hr after treatment, the mice were anesthetized with ether and frozen by immersion in dry ice/hexane. The mice were processed for whole-body autoradiography by the Ullberg technique; this procedure does not allow thawing or contact with solvents. All autoradiographs revealed some retention of radioactivity at early time intervals in the lacrimal glands, seminal vesicle fluid, nasal and olfactory epithelium, and retinal melanocytes. The remaining portion of the animal was densitometrically uniform except for the lower levels noted in the CNS and adipose tissues. Excretion of radioactivity by the liver and kidneys seems to be the major routes of elimination. Localization in the liver at late time intervals was confined principally to the centrilobular region. Late sites of retention, observed only after [1-methyl-14C]caffeine administration, included the pancreas, minor and major salivary glands, splenic red pulp, thymal cortex, bone marrow, and gastrointestinal epithelium. Sites of localization present in both studies included the olfactory epithelium, lacrimal glands, hair follicles, and retinal melanocytes. Further studies are needed to determine whether the localization at these various sites is due to metabolic degradation, active transport, or possibly a specific receptor interaction

  6. System for Automated Geoscientific Analyses (SAGA) v. 2.1.4

    Conrad, O.; Bechtel, B.; Bock, M.; Dietrich, H.; Fischer, E.; Gerlitz, L.; Wehberg, J.; Wichmann, V.; Böhner, J.

    2015-07-01

    The System for Automated Geoscientific Analyses (SAGA) is an open source geographic information system (GIS), mainly licensed under the GNU General Public License. Since its first release in 2004, SAGA has rapidly developed from a specialized tool for digital terrain analysis to a comprehensive and globally established GIS platform for scientific analysis and modeling. SAGA is coded in C++ in an object oriented design and runs under several operating systems including Windows and Linux. Key functional features of the modular software architecture comprise an application programming interface for the development and implementation of new geoscientific methods, a user friendly graphical user interface with many visualization options, a command line interpreter, and interfaces to interpreted languages like R and Python. The current version 2.1.4 offers more than 600 tools, which are implemented in dynamically loadable libraries or shared objects and represent the broad scopes of SAGA in numerous fields of geoscientific endeavor and beyond. In this paper, we inform about the system's architecture, functionality, and its current state of development and implementation. Furthermore, we highlight the wide spectrum of scientific applications of SAGA in a review of published studies, with special emphasis on the core application areas digital terrain analysis, geomorphology, soil science, climatology and meteorology, as well as remote sensing.

  7. System for Automated Geoscientific Analyses (SAGA v. 2.1.4

    O. Conrad

    2015-02-01

    Full Text Available The System for Automated Geoscientific Analyses (SAGA is an open-source Geographic Information System (GIS, mainly licensed under the GNU General Public License. Since its first release in 2004, SAGA has rapidly developed from a specialized tool for digital terrain analysis to a comprehensive and globally established GIS platform for scientific analysis and modeling. SAGA is coded in C++ in an object oriented design and runs under several operating systems including Windows and Linux. Key functional features of the modular organized software architecture comprise an application programming interface for the development and implementation of new geoscientific methods, an easily approachable graphical user interface with many visualization options, a command line interpreter, and interfaces to scripting and low level programming languages like R and Python. The current version 2.1.4 offers more than 700 tools, which are implemented in dynamically loadable libraries or shared objects and represent the broad scopes of SAGA in numerous fields of geoscientific endeavor and beyond. In this paper, we inform about the system's architecture, functionality, and its current state of development and implementation. Further, we highlight the wide spectrum of scientific applications of SAGA in a review of published studies with special emphasis on the core application areas digital terrain analysis, geomorphology, soil science, climatology and meteorology, as well as remote sensing.

  8. System for Automated Geoscientific Analyses (SAGA) v. 2.1.4

    Conrad, O.; Bechtel, B.; Bock, M.; Dietrich, H.; Fischer, E.; Gerlitz, L.; Wehberg, J.; Wichmann, V.; Böhner, J.

    2015-02-01

    The System for Automated Geoscientific Analyses (SAGA) is an open-source Geographic Information System (GIS), mainly licensed under the GNU General Public License. Since its first release in 2004, SAGA has rapidly developed from a specialized tool for digital terrain analysis to a comprehensive and globally established GIS platform for scientific analysis and modeling. SAGA is coded in C++ in an object oriented design and runs under several operating systems including Windows and Linux. Key functional features of the modular organized software architecture comprise an application programming interface for the development and implementation of new geoscientific methods, an easily approachable graphical user interface with many visualization options, a command line interpreter, and interfaces to scripting and low level programming languages like R and Python. The current version 2.1.4 offers more than 700 tools, which are implemented in dynamically loadable libraries or shared objects and represent the broad scopes of SAGA in numerous fields of geoscientific endeavor and beyond. In this paper, we inform about the system's architecture, functionality, and its current state of development and implementation. Further, we highlight the wide spectrum of scientific applications of SAGA in a review of published studies with special emphasis on the core application areas digital terrain analysis, geomorphology, soil science, climatology and meteorology, as well as remote sensing.

  9. MicroRNA-214 acts as a potential oncogene in breast cancer by targeting the PTEN-PI3K/Akt signaling pathway.

    Wang, Fang; Li, Lin; Chen, Zhuo; Zhu, Mingzhi; Gu, Yuanting

    2016-05-01

    Breast cancer ranks as the leading cause of cancer-related mortality in females worldwide. It has been proven that microRNAs (miRNAs or miRs), a type of non‑coding RNA, are involved in tumorigenesis. An increasing number of studies has confirmed the critical role of miR‑214 in certain types of cancer. Nevertheless, the biological function of miR‑214, as well as its underlying mechanisms of action in breast cancer remain largely unknown. In the present study, the expression of miR‑214 was found to be upregulated in four human breast cancer cell lines in contrast to its expression level in the non‑malignant breast epithelial cell line, MCF‑10A. Moreover, the overexpression of miR‑214 markedly increased cell viability and abrogated the apoptosis triggered by serum starvation, indicating that miR‑214 plays a pivotal role in breast cancer cell growth. Further analysis suggested that the upregulation of miR‑214 markedly induced the activation of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, which largely accounted for the protective effects of miR‑124 on cancer cell growth. This was further confimed by pre‑treatment with the PI3K/Akt inhibitor, LY294002, which markedly attenuated the miR‑214‑induced increase in cell viability and resistance to apoptosis. Furthermore, the expression of phosphatase and tensin homolog (PTEN) was decreased following transfection wtih miR‑214 mimics and PTEN was confirmed as the direct target of miR‑214 by bioinformatics analysis and a dual‑firefly luciferase reporter assay. Importantly, the introduction of PTEN cDNA lacking the 3' untranslated region (3'UTR) significantly inhibited the miR‑214‑induced activation of the PI3K/Akt signaling pathway, and abrogated the protetive effects of miR‑214 on cell survival and resistance to apoptosis. Taken together, these findings suggest that miR‑214 possesses oncogenic activity and that its effects are mediated through the promotion of cell

  10. Corrective Action Investigation Plan for Corrective Action Unit 214: Bunkers and Storage Areas Nevada Test Site, Nevada

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 214 under the Federal Facility Agreement and Consent Order. Located in Areas 5, 11, and 25 of the Nevada Test Site, CAU 214 consists of nine Corrective Action Sites (CASs): 05-99-01, Fallout Shelters; 11-22-03, Drum; 25-99-12, Fly Ash Storage; 25-23-01, Contaminated Materials; 25-23-19, Radioactive Material Storage; 25-99-18, Storage Area; 25-34-03, Motor Dr/Gr Assembly (Bunker); 25-34-04, Motor Dr/Gr Assembly (Bunker); and 25-34-05, Motor Dr/Gr Assembly (Bunker). These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). The suspected contaminants and critical analyte s for CAU 214 include oil (total petroleum hydrocarbons-diesel-range organics [TPH-DRO], polychlorinated biphenyls [PCBs]), pesticides (chlordane, heptachlor, 4,4-DDT), barium, cadmium, chronium, lubricants (TPH-DRO, TPH-gasoline-range organics [GRO]), and fly ash (arsenic). The land-use zones where CAU 214 CASs are located dictate that future land uses will be limited to nonresidential (i.e., industrial) activities. The results of this field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the corrective action decision document

  11. Detection of Helicobacter pylori infection by examination of human breath odor using electronic nose Bloodhound-214ST

    Shnayder, E. P.; Moshkin, M. P.; Petrovskii, D. V.; Shevela, A. I.; Babko, A. N.; Kulikov, V. G.

    2009-05-01

    Our aim was to examine the possibility of use e-nose Bloodhound-214ST to determine presence or absence of H. pylori infection using exhalation samples of patients. Breath samples were collected twice: at baseline and after oral administration of 500 mg of urea. H. pylori status of patients was confirmed by antral biopsy. Using two approaches for the data analysis we showed the possibility to distinguish H. pylori free and infected patients.

  12. Attached and Unattached Activity Size Distribution of Short-Lived Radon Progeny (214Pb) and Evaluation of Deposition Fraction

    Inhalation of 2'22Rn progeny in the domestic environment contributes the greatest fraction of the natural radiation exposure to the public. Dosimetric models are most often used in the assessment of human lung doses due to inhaled radioactivity because of the difficulty in making direct measurements. These models require information about the parameters of activity size distributions of radon progeny. The current study presents measured data on the attached and unattached activity size distributions of radon progeny in indoor air in El-Minia, Egypt. The attached fraction was collected using a low pressure Berner cascade impactor technique. A screen diffusion battery was used for collecting the unattached fraction. Most of the attached activities for 222Rn progeny were associated with aerosol particles of the accumulation mode. The mean activity median aerodynamic diameter (AMAD) of this mode for 214Pb was determined to be 401 nm with relative mean geometric standard deviation of 2.96. The mean value of specific air activity concentration of 214Pb associated with that mode was determined to be 4.74 %0.44 Bq m-3. The relative mean geometric standard deviations of unattached 214Pb was determined to be 1.21 with the mean activity thermodynamic diameter (AMTD) of 1.2 nm. The mean unattached activity concentration of 214Pb was found to be 0.44%0.14 Bq m-3. Based on the obtained results of radon progeny size distributions (unattached and attached), the deposition fractions in each airway generation of the human lung were evaluated by using a lung deposition model

  13. Transport and degradation of 2-14C abscicine acid in the coleus rehneltianus berger sprout

    1 μg ABA-2-14C aqueous solution was injected into the youngest or into a fully grown leaf of young and older coleus plants. The activity quantity in the various sprout parts is investigated after 2, 24 and 72 h; as well as which labelled substances other than abscisic acid (ABA) occur. The activity in the ethanol extracts was detected with the help of liquid scintillation measurements. Thin layer chromatography and gas chromatography were used to characterize the radioactive substances. The results show that ABA is degraded into three metabolites which are characterized by their relative Rsub(F) values using chromatography with LM 2 as substance 0.2, 0.5a, 0.5b and 0.8. Comparing with the literature shows that it could be 6'-hydroxy methyl ABA, ABA glucoside, phaseic acid and dihydrophaseic acid. Young and old leaves in older plants have the same ability to degrade ABA taking the occurence of the 0.8 metabolite as standard. The degradation in younger plants is firstly very slight. However, within 72 h the ability of ABA degradation is induced in older leaves of younger plants, so that finally the degradation rate is as big as in older plants. Activity is essentially exported by adult leaves of older plants. The basipetal transport is considerably greater than the acropetal one. Results show that mainly ABA is transported in the acropetal test, whereas ABA and fraction 0.5 are transported in the basipetal direction. A reversed transport direction is observed after applying ABA to a young leaf. The transport basipetal is polarized in the first two hours, after 72 hours of transport there is a definite acropetal polarity. (orig./MG)

  14. The causative agents in infective endocarditis: a systematic review comprising 33,214 cases.

    Vogkou, Christiana T; Vlachogiannis, Nikolaos I; Palaiodimos, Leonidas; Kousoulis, Antonis A

    2016-08-01

    Infective endocarditis (IE) incidence remains high with considerable fatality rates; guidelines for prophylaxis against IE are currently under review in some settings which highlights the importance of maintaining up-to-date epidemiological estimates about the most common microbial causes. The objective of this systematic review, following PRISMA guidelines, was to identify the most common microbial causes of IE in recent years. Medline was searched from January 1, 2003 to March 31, 2013 for all articles containing the term "infective endocarditis". All relevant studies reporting diagnostic results were included. Special patient subpopulations were assessed separately. A total of 105 studies were included, from 36 countries, with available data on a total of 33,214 cases. Staphylococcus aureus was found to be the most common microorganism, being the most frequent in 54.3 % of studies (N = 57) (and in 55.4 % of studies using Duke's criteria for diagnosis [N = 51]). Viridans group streptococci (VGS), coagulase-negative staphylococci (CoNS), Enterococcus spp and Streptococcus bovis were among the most common causes. S. aureus was the most common pathogen in almost all population subgroups; however, this was not the case in patients with implantable devices, prosthetic valves, or immunocompromised non-HIV, as well as in the sub-group from Asia, emphasizing that a global one-size-fits-all approach to the management of suspected IE is not appropriate. This review provides an evidence-based map of the most common causative agents of IE, highlighting S. aureus as the leading cause in the 21st century. The changing epidemiology of IE in some patient sub-groups in the last decade and the very high number of microbiologically undiagnosed cases (26.6 %) suggest the need to revisit IE prophylaxis and diagnostic strategies. PMID:27170145

  15. Psychiatric stigma in treatment seeking adults with personality problems: evidence from a sample of 214 patients.

    Kirsten eCatthoor

    2015-07-01

    Full Text Available Stigmatization is a major hindrance in adult psychiatric patients with Axis-I diagnoses, as shown consistently in most studies. Significantly fewer studies on the emergence of psychiatric stigma in adult patients with personality disorders exist, although the resulting evidence is conclusive. Some authors consider patients with personality disorders at risk for severe stigmatization because of intense difficulties during interpersonal contact, even in a psychotherapeutic relationship. The aim of this study was primarily the assessment of pre-existing stigma in patients referred for intensive treatment for personality disorders. The study enrolled 214 patients admitted to the adult department of a highly specialized mental health care institute offering psychotherapy for patients with severe and complex personality pathology. All patients underwent a standard assessment with self-report questionnaires and a semi-structured interview to measure Axis II personality disorders. The Stigma Consciousness Questionnaire (SCQ and the Perceived Devaluation-Discrimination Questionnaire (DDQ, both validated instruments, were used to measure perceived and actual experiences of stigma. Independent sample t-tests were used to investigate differences in the mean total stigma scores for patients both with and without a personality disorder. One-way ANOVA’s were performed to assess the differences between having a borderline personality disorder, another personality disorder, or no personality disorder diagnosis.Multiple regression main effect analyses were conducted in order to explore the impact of the different personality disorder diagnosis on the level of stigma. The mean scores across all patient groups were consistent with rather low stigma. No differences were found for patients with or without a personality disorder diagnosis. Level of stigma in general was not associated with an accumulating number of personality disorders.

  16. Educational experiment for students using natural radioactivity. 1. Radiochemical analysis of {sup 214}Bi in Ena and Ikeda mineral spring water

    Kamata, Masahiro [Faculty of Education, Tokyo Gakugei Univ., Koganei, Tokyo (Japan); Nakamura, Mariko; Esaka, Takao

    1999-09-01

    A couple of educational experiments have been developed using natural radioactivity contained in mineral spring water and a small GM counter. These experiments are safe and inexpensive enough to be conducted at high school or university, nevertheless they are quantitative enough for learners to observe half-life of {sup 214}Pb and {sup 214}Bi, and to help them understand the concept of radioactive equilibrium between them. (author)

  17. 结直肠癌中microRNA-214的表达及其与p53的关系

    赵增仁; 樊智彬; 张丽静; 吴晨鹏; 张学明; 刘博

    2013-01-01

    目的 探讨结直肠癌中microRNA-214(miR-214)的表达及其与p53的关系.方法 采用实时荧光定量聚合酶链反应的方法检测结直肠癌患者及结肠癌细胞株野生型HCT-116 p53+/+和突变型HCT-116 p53-/-中miR-214的表达情况,同时在结肠癌患者中检测p53的表达.结果 miR-214在癌旁正常黏膜中的表达明显高于癌组织(P=0.021),p53在癌旁正常黏膜中的表达明显低于癌组织;miR-214在HCT-116 p53-/-细胞株中的表达显著高于HCT-116 p53+/+(P=0.028),与p53的表达情况相反;在结直肠癌组织中miR-214与p53无明显相关性(rs=-0.156,P=0.409).结论 在结直肠癌的发生发展中miR-214可能通过调节p53 发挥抑癌基因的功能,但尚未发现miR-214与p53存在明显相关性.

  18. Transfección de la línea celular de salmón CHSE-214 usando un liposoma no comercial Transfection of salmon cellular line CHSE-214 using a non-commercial liposome

    M Aranda

    2007-01-01

    Full Text Available El rápido crecimiento de la acuicultura chilena ha incentivado la exploración de estrategias innovadoras de prevención sanitaria. Las vacunas de ADN se presentan como una alternativa viable para el control de enfermedades, pero existen barreras técnicas, como la vía de administración y los sistemas de transporte y entrega que necesitan ser soslayados. Los liposomas catiónicos son utilizados ampliamente en la incorporación de genes en líneas celulares mamíferas pero su alto costo hace prohibitivo su uso en escala comercial. Con el fin de abordar la problemática económica en la obtención del liposoma y para contribuir con un procedimiento de transfección in vitro en células de salmón, los objetivos de este trabajo fueron formular un liposoma a partir de polvo liofilizado de DOTAP y desarrollar un protocolo de transfección de vectores eucarióticos en la línea celular CHSE-214. Para ello se utilizaron los vectores pcDNA 4.0 HisMax I TOPO y pIRES-EGFP y la línea celular de salmón Chinook CHSE-214 (ATCC 1681, estableciendo tanto las características del liposoma formulado como las condiciones óptimas de transfección. Los resultados indicaron que el liposoma formulado desde polvo liofilizado de DOTAP comparte todas las características de los liposomas comerciales con la ventaja de poseer bajo costo, aproximadamente 10 veces menos. Con este liposoma se logró establecer un protocolo óptimo de transfección de células de peces CHSE-214, con vectores eucarióticos, no mostrando signos de toxicidad y permitiendo la expresión del gen incorporado en ambos vectores.The fast growth of Chilean aquaculture has impelled the exploration of new strategies of sanitary prevention. DNA vaccines appear as a feasible alternative for disease control, however there are technical barriers such as the form of administration and the carrier systems which need to be resolved. Liposomes are widely used for gene delivery in mammalian cell lines, but

  19. A convenient method for 14C-labeling of 2-methylthio-1-[4-N-α-ethoxycarbonylbenzyl)-amino-benzyl] -5-hydroxymethyl-2-[14C]-1H-imidazole and 1-[4-N-α-ethoxy-carbonylbenzyl)-aminobenzyl]-5-hydroxymethyl-2-[14C] -1H-imidazole as potential antihypertensives

    The key synthetic intermediate, (2-mercapto-1-(4-nitrobenzyl)-1H-imidazol-5-yl)methanol-[2-14C], has been synthesized by using one pot procedure from potassium[14C]-thiocyanate. It was converted to two nonpeptide angiotensin II receptor antagonists, 2-methylthio-1-[4-N-α-ethoxycarbonyl benzyl)-aminobenzyl]-5-hydroxymethyl-1H-imidazole-[2-14C] and 1-[4-N-α-ethoxy-carbonylbenzyl)-aminobenzyl] -5-hydroxymethyl-1H-imidazole-[2-14C] via a 3-step sequence synthetic pathway. (author)

  20. Adaptation of the quantitative 2-[14C]deoxyglucose method for use in freely moving rats.

    Crane, A M; Porrino, L J

    1989-10-01

    A procedure for venous and arterial catheterization is described which allows the quantitative 2-[14C]deoxyglucose method to be applied to freely moving animals for behavioral and pharmacological studies. The catheterization method is rapid, minimally invasive, and requires no complicated equipment. Physiological conditions and rates of cerebral glucose utilization in freely moving rats and in restrained rats have been compared. The results demonstrate that local cerebral glucose utilization can readily be measured in freely moving animals engaged in behavioral experiments. PMID:2804673

  1. Evaluation of drought response of two poplar clones (Populus x canadensis Monch 'I-214' and P. deltoides Marsh. 'Dvina') through high resolution analysis of stem growth.

    Giovannelli, Alessio; Deslauriers, Annie; Fragnelli, Giuseppe; Scaletti, Luciano; Castro, Gaetano; Rossi, Sergio; Crivellaro, Alan

    2007-01-01

    Different irrigation effects on stem radius variation (DeltaR) and maximum daily shrinkage (MDS) in Populus deltoides 'Dvina' and Populusxcanadensis 'I-214' were studied to assess differences in drought tolerance between clones. One-year-old trees growing in concrete tanks were submitted to two irrigation regimes (natural rainfall and irrigation) from 24 June to 10 August, and DeltaR was monitored by automatic point dendrometers. Independently of the irrigation regime, 'Dvina' showed a higher stem radial increment than 'I-214'. In both clones, the first response to changed soil water content was a significant increase in MDS, whilst DeltaR decreased about 20 d later when pre-dawn leaf water potential (Psipd) dropped below -0.4 MPa. However, they displayed different strategies to overcome drought. 'Dvina' maintained a positive DeltaR for longer than 'I-214', which had lower leaf Psipd and greater leaf abscission at the end of the drought period. After irrigation resumed, 'Dvina' showed a higher capacity to restore stem growth. 'I-214' was probably unable to recover secondary growth because of higher leaf abscission during drought stress and the production of newly expanded leaves during recovery. It is concluded that the larger radial growth of 'Dvina' derived from a better water use (carbon uptake versus water loss) than 'I-214' under limited water availability. PMID:17545226

  2. Impact of HIV-1 reverse transcriptase polymorphism F214L on virological response to thymidine analogue based regimens in ART-naïve and experienced patients

    Silberstein, F; Cozzi-Lepri, A; Ruiz, L;

    2007-01-01

    BACKGROUND: A negative association between the polymorphism F214L and type 1 thymidine analogue (TA) mutations (TAMs) has been observed. However, the virological response to TAs according to the detection of F214L has not been evaluated. METHODS: We studied 590 patients from EuroSIDA who started TA...... therapy for the first time as part of potent combination antiretroviral therapy (cART) and who were tested for genotypic resistance within the past 6 months. End points were median reduction in the week 24 viral load and time to virological failure (2 consecutive VL measurements >400 copies/mL after at...... least 6 months of the TA-containing cART). RESULTS: In ART-naive patients, the prevalence of F214L was 17%. By 48 months after starting TA-based cART, the proportion of patients who experienced virological failure was 16% in patients with 214L and 36% in those with 214F (P=.03). In a multivariable Cox...

  3. Production and assay of cellulolytic enzyme activity of Enterobacter cloacae WPL 214 isolated from bovine rumen fluid waste of Surabaya abbatoir, Indonesia

    W. P. Lokapirnasari

    2015-03-01

    Full Text Available Aim: This study aims to produce and assay cellulolytic enzyme activity (endo-(1,4-β-D-glucanase, exo-(1,4-β-Dglucanase, and β-glucosidase, at optimum temperature and optimum pH of Enterobacter cloacae WPL 214 isolated from bovine rumen fluid waste of Surabaya Abbatoir, Indonesia. Materials and Methods: To produce enzyme from a single colony of E. cloacae WPL 214, 98 × 1010 CFU/ml of isolates was put into 20 ml of liquid medium and incubated in a shaker incubator for 16 h at 35°C in accordance with growth time and optimum temperature of E. cloacae WPL 214. Further on, culture was centrifuged at 6000 rpm at 4°C for 15 min. Pellet was discarded while supernatant containing cellulose enzyme activity was withdrawn to assay endo-(1,4-β-D-glucanase, exo-(1,4-β-D-glucanase, and β-glucosidase. Results: Cellulase enzyme of E. cloacae WPL 214 isolates had endoglucanase activity of 0.09 U/ml, exoglucanase of 0.13 U/ml, and cellobiase of 0.10 U/ml at optimum temperature 35°C and optimum pH 5. Conclusion: E. cloacae WPL 214 isolated from bovine rumen fluid waste produced cellulose enzyme with activity as cellulolytic enzyme of endo-(1,4-β-D-glucanase, exo-(1,4-β-D-glucanase and β-glucosidase.

  4. Effect of planting density on the development of tree and plantation volume of Populus x euramericana (Dode) Guinier cl. I-214

    Vučković Milivoj; Andrašev Siniša; Rončević Savo; Bobinac Martin

    2005-01-01

    The effect of plantation density on the stem volume development phases of mean trees of Populus x euramericana (Dode) Guinier, cl. I-214 were studied in the test plantation aged 25 years with two different planting densities 4.25x4.25 m (treatment A) and 6.00x6.00 m (treatment B). The modeling of stem volume growth of mean trees enabled the identification of development phases based on biological laws. Different growth dynamics of mean trees of the clone I-214, depending on plantation density...

  5. 214例婴儿缺铁性贫血的特点及其相关因素分析%Analysis on Features and Related Factors of Iron Deficiency Anemia in 214 Infants

    李蕙; 周敏; 曹雪梅; 徐鸣; 李丹; 史宏

    2011-01-01

    Objective To analyze the clinical characteristics and the risk factors of iron deficiency anemia (IDA) in infants.Methods The retrospective study of clinical data involving 214 IDA inpatients aged 4- 12 months old in our hospital from January 2002 to June 2009 was carried out.Results Among 214 infantile cases, infants less than 6 months old accounted 12.62% and infants more than 6 months old accounted for 87.38%.Rural infants with IDA were more prevalent than city infants (61.21% vs.38.79% ).Most of these IDA infants had mild to moderate anemia degree (56.54% and 38.79% ), only 4.67% inpatients were severe anemia.The prevalence rate of IDA in infants with breast- feeding without food supplement on time was 29.44%, which was more than that in infants with artificial feeding and mixed feeding.Most of these infants were full term infants (89.25% ), while only 10.75% were premature or twins.Laboratory examination indicated serum iron decrease (49.06% ), ferritin decrease (56.07%) and serum transferrin receptor increase (33.33%).A hundred and eighty - four cases (85.98%) of these IDA infants were hospitalized because of varied complications such as respiratory infection.Conclusion Infants with IDA are more prevalent in rural infants more than 6 months old, in which the main cause is breast- feeding without food supplement on time.And IDA is often neglected because most of the patients could see a doctor due to complicating diseases.Prevention aiming at high risk groups, early diagnosis and early treatment are very important.%目的 分析医院婴儿缺铁性贫血的特点和相关危险因素.方法 回顾性分析儿童医院2002年1月至2009年6月收治的214例缺铁性贫血患儿的临床资料.结果 214例患儿中,6月龄以下占12.62%,6月龄以上占87.38%;农村患儿占61.21%,城市患儿占38.79% ;轻度贫血占56.54%,中度贫血占38.79%,重度贫血占4.67%;母乳喂养但未按时添加辅食者占29.44%;足月儿占89

  6. Measurement of the Thallium 208 and Bismuth 214 radiopurities of a molybdenum foil with the NEMO detector

    The NEMO 2 detector consists of a tracking volume to reconstruct electron trajectories associated with plastic scintillators. The purpose of the R and D is to aid in studies of neutrinoless double β decay. Using the first nine months of data from the NEMO 2 detector, a method of measurement of the 208Tl and 214Bi radiopurities is presented. These isotopes contribute to the background in the 3 MeV region corresponding to the Q of 2β(0ν) for molybdenum. The channel 1e1γ is used. Monte Carlo simulations with GEANT give the corresponding efficiencies. Radiopurities for a standard Molybdenum foil and for two high purity molybdenum samples have been measured. The results are in good agreement with γ-spectroscopy measurements using an HPGe crystal. 2000 hours of data yields a sensitivity of .3 events/min/kg

  7. Degradation of Triazine-2-(14)C Metsulfuron-Methyl in Soil from an Oil Palm Plantation.

    Ismail, B S; Eng, O K; Tayeb, M A

    2015-01-01

    Triazine-2-(14)C metsulfuron-methyl is a selective, systemic sulfonylurea herbicide. Degradation studies in soils are essential for the evaluation of the persistence of pesticides and their breakdown products. The purpose of the present study was to investigate the degradation of triazine-2-(14)C metsulfuron-methyl in soil under laboratory conditions. A High Performance Liquid Chromatograph (HPLC) equipped with an UV detector and an on-line radio-chemical detector, plus a Supelco Discovery column (250 x 4.6 mm, 5 μm), and PRP-1 column (305 x 7.0 mm, 10 μm) was used for the HPLC analysis. The radioactivity was determined by a Liquid Scintillation Counter (LSC) in scintillation fluid. The soil used was both sterilized and non-sterilized in order to observe the involvement of soil microbes. The estimated DT50 and DT90 values of metsulfuron-methyl in a non-sterile system were observed to be 13 and 44 days, whereas in sterilized soil, the DT50 and DT90 were 31 and 70 days, respectively. The principal degradation product after 60 days was CO2. The higher cumulative amount of (14)CO2 in (14)C-triazine in the non-sterilized soil compared to that in the sterile system suggests that biological degradation by soil micro-organisms significantly contributes to the dissipation of the compound. The major routes of degradation were O-demethylation, sulfonylurea bridge cleavage and the triazine "ring-opened." PMID:26437264

  8. Degradation of Triazine-2-(14C Metsulfuron-Methyl in Soil from an Oil Palm Plantation.

    B S Ismail

    Full Text Available Triazine-2-(14C metsulfuron-methyl is a selective, systemic sulfonylurea herbicide. Degradation studies in soils are essential for the evaluation of the persistence of pesticides and their breakdown products. The purpose of the present study was to investigate the degradation of triazine-2-(14C metsulfuron-methyl in soil under laboratory conditions. A High Performance Liquid Chromatograph (HPLC equipped with an UV detector and an on-line radio-chemical detector, plus a Supelco Discovery column (250 x 4.6 mm, 5 μm, and PRP-1 column (305 x 7.0 mm, 10 μm was used for the HPLC analysis. The radioactivity was determined by a Liquid Scintillation Counter (LSC in scintillation fluid. The soil used was both sterilized and non-sterilized in order to observe the involvement of soil microbes. The estimated DT50 and DT90 values of metsulfuron-methyl in a non-sterile system were observed to be 13 and 44 days, whereas in sterilized soil, the DT50 and DT90 were 31 and 70 days, respectively. The principal degradation product after 60 days was CO2. The higher cumulative amount of (14CO2 in (14C-triazine in the non-sterilized soil compared to that in the sterile system suggests that biological degradation by soil micro-organisms significantly contributes to the dissipation of the compound. The major routes of degradation were O-demethylation, sulfonylurea bridge cleavage and the triazine "ring-opened."

  9. Planck intermediate results: VI. The dynamical structure of PLCKG214.6+37.0, a Planck discovered triple system of galaxy clusters

    Castex, G.; Delabrouille, J.; Ganga, K.; Giraud-Héraud, Y.; Le Jeune, M.; Patanchon, G.; Piat, M.; Roman, M.; Rosset, C.; Hobson, M.; Bhatia, R.; Bond, J.R.; Bernard, J.-P.; Hildebrandt, S.R.; Da Silva, A.; Melin, J.-B.; Yvon, D.; Nørgaard-Nielsen, Hans Ulrik; Frommert, M.; Atrio-Barandela, F.; Bikmaev, I.; Scott, D.; Pierpaoli, E.; Juvela, M.; Keihänen, E.; Jones, W.C.; Knox, L.; Zonca, A.; Cayón, L.; Matarrese, S.; De Bernardis, P.; Masi, S.; Nati, F.; Piacentini, F.; Balbi, A.; Bourdin, H.; De Gasperis, G.; Mazzotta, P.; Vittorio, N.; Cabella, P.; Kneissl, R.; Dupac, X.; Jagemann, T.; Leonardi, R.; Mendes, L.; Tauber, J.A.; Kurki-Suonio, H.; Lähteenmäki, A.; Poutanen, T.; Suur-Uski, A.-S.; Colafrancesco, S.; Polenta, G.; Frailis, M.; Galeotta, S.; Gregorio, A.; Maris, M.; Pasian, F.; Zacchei, A.; Massardi, M.; Burigana, C.; Cuttaia, F.; Finelli, F.; Franceschi, E.; Gruppuso, A.; Mandolesi, N.; Morgante, G.; Natoli, P.; Paoletti, D.; Ricciardi, S.; Sandri, M.; Terenzi, L.; Valenziano, L.; Villa, F.; Bersanelli, M.; Donzelli, S.; Maino, D.; Mennella, A.; Rossetti, M.; Tomasi, M.; Melchiorri, A.; Chamballu, A.; Clements, D.L.; Jaffe, A.H.; Mortlock, D.; Novikov, D.; Rusholme, B.; Benoît, A.; Aghanim, N.; Aumont, J.; Dole, H.; Douspis, M.; Kunz, M.; Lagache, G.; Miville-Deschênes, M.-A.; Pajot, F.; Ponthieu, N.; Puget, J.-L.; Remazeilles, M.; Welikala, N.; Moneti, A.; Sygnet, J.-F.; Popa, L.; Marleau, F.; Chiang, L.-Y.; Efstathiou, G.; Dahle, H.; Eriksen, H.K.; Hansen, F.K.; Lilje, P.B.; Génova-Santos, R.T.; Hempel, A.; Rebolo, R.; Rubiño-Martín, J.A.; Barreiro, R.B.; Diego, J.M.; Herranz, D.; López-Caniego, M.; Martínez-González, E.; Toffolatti, L.; Vielva, P.; Bartlett, J.G.; Colombo, L.P.L.; Doré, O.; Holmes, W.A.; Lawrence, C.R.; Mitra, S.; Rocha, G.; Wade, L.A.; Bonaldi, A.; Davis, R.J.; Noviello, F.; Zaroubi, S.; Ashdown, M.; Harrison, D.; Lasenby, A.; Sutton, D.; Henrot-Versillé, S.; Luzzi, G.; Perdereau, O.; Plaszczynski, S.; Tristram, M.; Coulais, A.; Lamarre, J.-M.; Arnaud, M.; Démoclès, J.; Marshall, D.J.; Piffaretti, R.; Pratt, G.W.; Starck, J.-L.; Cardoso, J.-F.; Catalano, A.; Comis, B.; Hurier, G.; Macías-Pérez, J.F.; Perotto, L.; Renault, C.; Van Tent, B.; Kisner, T.S.; Smoot, G.F.; Dörl, U.; Enßlin, T.A.; Hernández-Monteagudo, C.; Knoche, J.; Rachen, J.P.; Reinecke, M.; Riller, T.; Böhringer, H.; Chon, G.; Tuovinen, J.; Murphy, J.A.; Christensen, P.R.; Naselsky, P.; Novikov, I.; Crill, B.P.; Savini, G.; Baccigalupi, C.; Danese, L.; De Zotti, G.; González-Nuevo, J.; Perrotta, F.; Ade, P.A.R.; Munshi, D.; Sudiwala, R.; Burenin, R.; Gilfanov, M.; Sunyaev, R.; Borrill, J.; Osborne, S.; Khamitov, I.; Heinämäki, P.; Benabed, K.; Bouchet, F.R.; Colombi, S.; Hivon, E.; Prunet, S.; Wandelt, B.D.; Mei, S.; Banday, A.J.; Flores-Cacho, I.; Forni, O.; Giard, M.; Jaffe, T.R.; Montier, L.; Pointecouteau, E.; Ristorcelli, I.; Dolag, K.; Battaner, E.; Górski, K.M.

    2013-01-01

    The survey of galaxy clusters performed by Planck through the Sunyaev-Zeldovich effect has already discovered many interesting objects, thanks to its full sky coverage. One of the SZ candidates detected inthe early months of the mission near to the signal-to-noise threshold, PLCKG214.6+37.0, was ...

  10. Investigation on drug-resistance of 214 strains of Escherichia coli from various specimens%不同标本大肠埃希菌214株耐药性调查

    赵丽娟; 汤丽霞; 黄干荣; 覃志坚

    2002-01-01

    目的调查不同标本大肠埃希菌(E. Coli)的分布及耐药特点.方法常规方法对临床各种标本进行细菌分离培养,采用FORTUNE2000微生物鉴定仪进行鉴定和药敏试验.结果 214株E. Coli中从尿中分离出96株(44.86%),占各类标本的首位.尿中与非尿中E. Coli的耐药性不同,尿中E. Coli对复合磺胺、氟哌酸、环丙沙星等的耐药率显著高于其他部位分离者(P〈0.05),而尿中E. Coli对呋喃妥因的耐药率明显低于非尿中E. Coli(P<0.05).在22种抗生素中,对5种以上耐药的菌株有162株.结论尿中分离的E. Coli对环丙沙星、氟哌酸、氯霉素、复合磺胺耐药率高于其他标本分离者.

  11. SXP214, an X-ray Pulsar in the Small Magellanic Cloud, Crossing the Circumstellar Disk of the Companion

    Hong, JaeSub; Zezas, Andreas; Haberl, Frank; Drake, Jeremy J; Plucinsky, Paul P; Gaetz, Terrance; Sasaki, Manami; Williams, Benjamin; Long, Knox S; Blair, William P; Winkler, P Frank; Wright, Nicholas J; Laycock, Silas; Udalski, Andrzej

    2016-01-01

    Located in the Small Magellanic Cloud (SMC), SXP214 is an X-ray pulsar in a high mass X-ray binary system with a Be-star companion. A recent survey of the SMC under a Chandra X-ray Visionary program found the source in a transition when the X-ray flux was on a steady rise. The Lomb-Scargle periodogram revealed a pulse period of 211.49 +/- 0.42 s, which is significantly (>5sigma) shorter than the previous measurements with XMM-Newton and RXTE. This implies that the system has gone through sudden spin-up episodes recently. The pulse profile shows a sharp eclipse-like feature with a modulation amplitude of >95%. The linear rise of the observed X-ray luminosity from <~2x to 7x10^35 erg s^-1 is correlated with steady softening of the X-ray spectrum, which can be described by the changes in the local absorption from N_H ~ 10^24 to <~10^20 cm^-2 for an absorbed power-law model. The soft X-ray emission below 2 keV was absent in the early part of the observation when only the pulsating hard X-ray component was o...

  12. Physical-mechanical properties and bonding quality of heat treated poplar (I-214 clone and ceiba plywood

    Goli G

    2015-10-01

    Full Text Available The present paper investigates the physical and mechanical modifications of both poplar (I-214 clone and ceiba veneers and plywood after heat treatments of different intensities (5 and 7 % of dry mass losses. Plywood panels were glued before and after heat treatment with urea-formaldehyde (UF and melamine-urea-formaldehyde (MUF resins. In order to assess the treatments’ effects on both the wood and the glues, the dry mass, the density, the bending strength, the Young’s modulus and the bonding quality were measured before and after heat treatment. The results of the different treatments were compared as well. Results showed that the loss in cell wall polymers due to the heat treatment caused a significant reduction of the equilibrium moisture content of the samples. From a mechanical point of view the treatment resulted in an important reduction of strength and in a small reduction of stiffness. Bonding quality as well as mechanical properties were widely affected by the heat treatment. The different intensities of the treatments (the treatment range was up to 5% and 7% of dry mass loss did not show significant differences for most of the features assessed. The mechanical performance as well as the bonding quality of treated samples suggested that veneers should be glued after heat treatment. Apparent cohesive wood failure showed that different degradations affect wood and glues with a prominent effect on the glues for UF resins and a prominent effect on the wood for MUF resins.

  13. The XMM-Newton survey of the Small Magellanic Cloud: XMMUJ005011.2-730026 = SXP214, a Be/X-ray binary pulsar

    Coe, M J; Sturm, R; Pietsch, W; Townsend, L J; Bartlett, E S; Filipovic, M; Udalski, A; Corbet, R H D; Tiengo, A; Ehle, M; Payne, J L; Burton, D

    2011-01-01

    In the course of the XMM-Newton survey of the Small Magellanic Cloud (SMC), a region to the east of the emission nebula N19 was observed in November 2009. To search for new candidates for high mass X-ray binaries the EPIC PN and MOS data of the detected point sources were investigated and their spectral and temporal characteristics identified. A new transient (XMMUJ005011.2-730026= SXP214) with a pulse period of 214.05 s was discovered; the source had a hard X-ray spectrum with power-law index of ~0.65. The accurate X-ray source location permits the identification of the X-ray source with a ~15th magnitude Be star, thereby confirming this system as a new Be/X-ray binary.

  14. Novel ZEB2-BCL11B Fusion Gene Identified by RNA-Sequencing in Acute Myeloid Leukemia with t(2;14(q22;q32.

    Synne Torkildsen

    Full Text Available RNA-sequencing of a case of acute myeloid leukemia with the bone marrow karyotype 46,XY,t(2;14(q22;q32[5]/47,XY,idem,+?4,del(6(q13q21[cp6]/46,XY[4] showed that the t(2;14 generated a ZEB2-BCL11B chimera in which exon 2 of ZEB2 (nucleotide 595 in the sequence with accession number NM_014795.3 was fused to exon 2 of BCL11B (nucleotide 554 in the sequence with accession number NM_022898.2. RT-PCR together with Sanger sequencing verified the presence of the above-mentioned fusion transcript. All functional domains of BCL11B are retained in the chimeric protein. Abnormal expression of BCL11B coding regions subjected to control by the ZEB2 promoter seems to be the leukemogenic mechanism behind the translocation.

  15. Elements of structure and productivity of clone I-214 (Populus×euramericana (Dode Guinier plantations on the river Sava alluvium

    Andrašev Siniša

    2010-01-01

    Full Text Available Two experimental plantations of Euramerican poplar (Populus×euramericana (Dode Guinier - clone I-214 were researched on the river Sava alluvium in Srem. Three sample plots were established in each of the plantations, aged 31 years. The soil type was humofluvisol (alluvial semigley, planting space 6×6 m. The plantations were established with 278 rooted cuttings per hectare, and the number of trees at the age of 31 accounted for 46.5-60.6%. The constructed height curves, mean stand height (hg and upper (hg20% heights show that the study plantations were established on different site classes, which was significantly reflected on other plantation growth elements and productivity. However, there was no significant effect of site class on the variability (sd and cv and shape of diameter structure (α3 and α4. The constructed models of diameter structure for each site class (by Weibull function differ by location parameter (a, and do not differ by parameter of scale (b and shape (c. The tree and plantation growth elements show a high production potential of the clone I-214 which indicates that, on optimal soils and with the provided technological measures in the stage of nursery production and in the stage of plantation establishment, clone I-214 presents the good base for high production effects.

  16. Twelve-year experience of radioembolization for colorectal hepatic metastases in 214 patients: survival by era and chemotherapy

    Lewandowski, Robert J.; Memon, Khairuddin; Hickey, Ryan; Gates, Vanessa L.; Atassi, Bassel; Vouche, Michael; Atassi, Rohi; Desai, Kush; Hohlastos, Elias; Sato, Kent; Habib, Ali [Robert H. Lurie Comprehensive Cancer Center, Department of Radiology, Section of Interventional Radiology, Northwestern Memorial Hospital, Chicago, IL (United States); Mulcahy, Mary F.; Kircher, Sheetal; Newman, Steven B.; Nimeiri, Halla; Benson, Al B. [Northwestern University, Department of Medicine, Division of Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL (United States); Marshall, Karen; Williams, Melissa; Salzig, Krystina; Salem, Riad [Robert H. Lurie Comprehensive Cancer Center, Department of Radiology, Section of Interventional Radiology, Northwestern Memorial Hospital, Chicago, IL (United States); Northwestern University, Department of Medicine, Division of Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL (United States)

    2014-10-15

    The aim of this study was to analyze the safety, treatment characteristics and survival outcomes of Yttrium-90 (Y90) radioembolization for unresectable colorectal carcinoma (CRC) liver metastases refractory to standard of care therapy. A total of 214 patients with CRC metastases were treated with Y90 radioembolization over 12 years. Toxicity was assessed using National Cancer Institute common terminology criteria. Overall survival was analyzed from date of diagnosis of primary cancer, hepatic metastases and from the first Y90. Uni/multivariate analyses were performed. Substratification by era of chemotherapeutics was performed. Most patients were male (60 %) and <65 years old (61 %). Of them, 98 % had been exposed to chemotherapy. Grade 3 lymphocyte, bilirubin, albumin, ALP and AST toxicities were observed in 39 %, 11 %, 10 %, 8 % and 4 % of patients, respectively. Grade 4 lymphocyte and ALP toxicities were observed in 5 % and 3 % of patients, respectively. Median overall survival was 43.0, 34.6, and 10.6 months from date of diagnosis of primary cancer, hepatic metastases and first Y90, respectively. Survival was significantly longer in patients: (1) who received ≤2 cytotoxic drugs (n = 104) than those who received 3 (n = 110) (15.2 vs. 7.5 months, p = 0.0001); and (2) who received no biologic agents (n = 52) compared with those that did (n = 162) (18.6 vs. 9.4 months, p = 0.0001). Multivariate analyses identified ≤2 cytotoxic agents, no exposure to biologics, ECOG 0, tumor burden <25 %, lack of extrahepatic disease and albumin >3 g/dL as independent predictors of survival. In this largest metastatic CRC series published to date, Y90 radioembolization was found to be safe; survival varied by prior therapy. Further studies are required to further refine the role of Y90 in metastatic CRC. (orig.)

  17. SXP 214: An X-Ray Pulsar in the Small Magellanic Cloud, Crossing the Circumstellar Disk of the Companion

    Hong, JaeSub; Antoniou, Vallia; Zezas, Andreas; Haberl, Frank; Drake, Jeremy J.; Plucinsky, Paul P.; Gaetz, Terrance; Sasaki, Manami; Williams, Benjamin; Long, Knox S.; Blair, William P.; Winkler, P. Frank; Wright, Nicholas J.; Laycock, Silas; Udalski, Andrzej

    2016-07-01

    Located in the Small Magellanic Cloud (SMC), SXP 214 is an X-ray pulsar in a high mass X-ray binary system with a Be-star companion. A recent survey of the SMC under a Chandra X-ray Visionary program found that the source was in a transition when the X-ray flux was on a steady rise. The Lomb–Scargle periodogram revealed a pulse period of 211.49 ± 0.42 s, which is significantly (>5σ) shorter than the previous measurements made with XMM-Newton and RXTE. This implies that the system has gone through sudden spin-up episodes recently. The pulse profile shows a sharp eclipse-like feature with a modulation amplitude of >95%. The linear rise of the observed X-ray luminosity from ≲2× to 7× {10}35 erg s‑1 is correlated with a steady softening of the X-ray spectrum, which can be described by the changes in the local absorption from N H ∼ 1024 to ≲1020 cm‑2 for an absorbed power-law model. The soft X-ray emission below 2 keV was absent in the early part of the observation when only the pulsating hard X-ray component was observed, whereas at later times, both soft and hard X-ray components were observed to be pulsating. A likely explanation is that the neutron star was initially hidden in the circumstellar disk of the companion, and later came out of the disk with the accreted material that continued fueling the observed pulsation.

  18. Ten-year experiences with Tracheostomy at a University teaching hospital in Northwestern Tanzania: A retrospective review of 214 cases

    Gilyoma Japhet M

    2011-11-01

    Full Text Available Abstract Background Tracheostomy remains a very important life saving surgical procedure worldwide and particularly in our environment where patients present late in upper airway obstruction. Little work has been done on this subject in our environment and therefore it was necessary to conduct this study to describe our own experiences with tracheostomy, outlining the common indications and outcome of tracheostomized patients in our setting and compare our results with those from other centers in the world. Methods This was a 10-year retrospective study which was conducted at Bugando Medical Centre from January 2001 to December 2010. Data were retrieved from patients' files kept in the Medical record department and analyzed using SPSS computer software version 15.0. Ethical approval to conduct the study was obtained from relevant authority before the commencement of the study. Results A total of 214 patients were studied. The male to female ratio was 3.1: 1. The majority of patients were in the 3rd decade of life. The most common indication for tracheostomy was upper airway obstruction secondary to traumatic causes in 55.1% of patients, followed by upper airway obstruction due to neoplastic causes in 39.3% of cases. The majority of tracheostomies (80.4% were performed as an emergency. Transverse skin crease incision was employed in all the cases. Post-tracheostomy complication rate was 21.5%. Complication rate was significantly higher in emergency tracheostomy than in electives (P Conclusion Upper airway obstruction secondary to trauma and laryngeal tumors still remains the most common indication for tracheostomy in our centre and tracheostomy is still a life saving procedure in the surgical management of airway despite complications which are seen more commonly in paediatric patients. Most of tracheostomy related complications can be avoided by meticulous attention to the details of the technique and postoperative tracheostomy care by skilled

  19. Study on Bone Mineral Density and its Influencing Factors among 1 214 Older Adults in Xuhui District, Shanghai

    Jian-ping CHEN; Mao-hua MIAO; Li-feng ZHOU; Jie YANG; Guang-hua LU; Xiao-ping ZHOU; Hui-qin YU; Er-sheng GAO

    2006-01-01

    Objective To understand the status of the forearm bone mineral density (BMD) in older adults, and to identify the potentialfactors influencing BMD.Methods A total of 1 214 older adults were examined, in Tianlin, Fenglin and Xietu sub-districts, of Xuhui district, Shanghai. BMD was tested at the left forearm,including distal radius and ulna 1/3 total, distalradius where the distance of radius and ulna is 8 mm, ultra-distal radius, by single energy X-ray densitometer.Results The BMD at all of the four sites decreased with the age increased. The average BMD was higher in male than in female for the same age and measured site.Distal radius 1/3 total had the highest BMD among the four sites. The incidence of low BMD and osteoporosis in distal forearm 1/3 radius total ascended with the age increased.Multiplied logistic regression showed that males had a lower risk to be low BMD (OR=0.19) compared with female. Compared with the group aged from 50 to 54, the odds ratio in the group aged from 55 to 59, 60 to 64, and 65 to 70 were respectively 3.17,5.13, 15.03. Compared with those whose monthly salary was less than 1 000, the odds ratio was 0.70 in those whose salary was more than 1 000.Conclusion The incidence of low BMD was high in older adults, and it is related with sex, age, monthly salary.

  20. Epidote-Bearing Veins in the State 2-14 Drill Hole: Implications for Hydrothermal Fluid Composition

    Caruso, L. J.; Bird, D. K.; Cho, M.; Liou, J. G.

    1988-11-01

    Epidote-bearing veins in State 2-14 drill core from 900 to 2960 m depth were examined using backscattered electron microscopy and electron probe microanalysis to characterize the mineralogy, parageneses, texture, and composition of vein minerals. In order of decreasing abundance, minerals in epidote-bearing veins are pyrite, calcite, K-feldspar, quartz, anhydrite, hematite, chlorite, Fe-Cu-Zn sulfides, actinolite, titanite, and allanite. The downhole distribution of minerals in epidote-bearing veins (+ pyrite and quartz) varies as a function of depth and includes: (1) calcite above ˜2000 m, (2) K-feldspar between 1700 and 2745 m, (3) anhydrite between 2195 and 2745 m, (4) hematite ± sulfides above 2773 m, and (5) actinolite below ˜2890 m. Where present, K-feldspar was the first mineral to precipitate in veins followed by epidote. In all other veins, epidote was the earliest vein mineral to form. Calcite, quartz, anhydrite, hematite, and sulfides were paragenetically later. Compositional zoning, common in most vein epidotes, is typically symmetric with Al-rich cores and Fe3+ -rich rims. The minimum mole fraction of Ca2Fe3Si3O12(OH) (XPs) in vein epidotes decreases systematically with increasing depth from ˜0.33 at 906 m to ˜0.21 at 2900 m, and the maximum XPs at any given depth is greater than 0.33. Thermodynamic analyses of phase relations among vein-filling minerals and aqueous solutions at depths near 1867 m and 300°C indicate that the modern reservoir fluid in the Salton Sea geothermal system is in equilibrium with calcite + hematite + quartz + epidote (XPs = 0.33) ± anhydrite. The predicted fugacity of CO2 (˜14 bars) for the modern Salton Sea brine is in close agreement with the calculated value of fCO2 for the 1867 m production fluid. Theoretical phase diagrams in the system CaO-K2O-Fe2O3-Al2O3-SiO2-H2O-O2-S2-CO2 demonstrate that the mineralogies and mineral parageneses recorded hi epidote-bearing veins and the observed variations in Al-Fe3+ content of

  1. Measurement of {sup 214} Pb, {sup 212} Pb {sup 210} Pb and {sup 7} Be activities in sizes fractionated aerosols in the lower atmosphere at Sacavem (Lisbon)

    Reis, Mario J.; Brogueira, Alfredo L.; Bettencourt, Antonio O. [Instituto Tecnologico e Nuclear, Sacavem (Portugal). Dept. de Protecao Radiologica e Seguranca Nuclear; Rosa, Rui N. [Universidade de Evora (Portugal). Dept. de Fisica

    2001-07-01

    Aerodynamic size distribution measurements of {sup 214} Pb, {sup 212} Pb {sup 210} Pb and {sup 7} Be were carried out using a five-stage high-volume cascade impactor with effective cut-off diameters of 0.49, 0.95, 1.5, 3.0, and 7.2 {mu}m. The activity of the samples was measured by {gamma}-ray spectrometry using both coaxial and ultra-low background well-type HPGe detectors. The activity size distribution measurements indicate that all radionuclides were associated with submicron aerosol in the accumulation mode, being {sup 210} Pb and {sup 7} Be attached to slightly larger particles, when compared to short-lived radon and thoron daughters. The mass size distributions show a significant contribution from aerosol particles larger than 7.2 {mu}m to the total mass concentration, which indicates the occurrence of resuspension processes. However, since that in most of the samples no {sup 210} Pb and short-lived {sup 214} Pb and {sup 212} Pb were found in association with larger particles, it seems that those nuclides were mostly originated by the decay of atmospheric radon (or thoron in the case of {sup 212} Pb) instead of soil resuspension. On average it was observed that about 80% of the {sup 214} Pb and {sup 212} Pb activity was associated with aerosol particles with aerodynamic diameters smaller than 0.49 {mu}m and about 90% with particles smaller than 0.95 {mu}m. (author)

  2. A Functional Variant at the miR-214 Binding Site in the Methylenetetrahydrofolatereductase Gene Alters Susceptibility to Gastric Cancer in a Chinese Han Population

    Qiaoyun Chen

    2015-05-01

    Full Text Available Background and Aims: Single nucleotide polymorphisms in miRNA binding sites, which are located in mRNA 3' untranslated regions (3'-UTRs, were recently found to influence microRNA-target interactions. Specifically, such polymorphisms can modulatebinding affinity or create or destroy miRNA-binding sites; such variants have also been found to be associated with cancer risk. In this study, we explored the effect of a functional variant at the miR-214 binding site in the methylenetetrahydrofolate reductase gene (rs114673809 on gastric cancer (GC risk in a hospital-based case-control study in a Chinese Han population. Methods and Results: We genotyped the rs114673809 polymorphism in 345 gastric cancer patients and 376 cancer-free controls using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP technique. The functions of rs114673809 were investigated using a luciferase activity assay and validated by immunoblotting. We found that participants carrying the rs114673809 AA genotype or A allele had a significantly increased risk of gastric cancer (OR = 1.667, 95% CI = 1.044-2.660, P = 0.034; OR = 1.261, 95% CI = 1.017-1.563, P = 0.037, respectively compared to those carrying the GG genotype and G allele. In addition, rs114673809 modified the binding of hsa-miR-214 to MTHFR as well as MTHFR protein levels in gastric cancer patients. Conclusion: Our data suggested that rs114673809, which is located at the miR-214 binding site in the 3'-UTR of MTHFR, may play an important role in the development of gastric cancer in a Chinese Han population.

  3. SOLVENT HOLD TANK SAMPLE RESULTS FOR MCU-14-135/136 AND MCU-14-214/215/216: FEBRUARY AND MARCH 2014 MONTHLY SAMPLES

    Fondeur, F.; Taylor-Pashow, K.

    2014-06-30

    SRNL received two sets of SHT samples (MCU-14-135-136 in February 2014 and MCU-14-214-216 in March 2014) for analysis. The samples were analyzed for composition. As with the previous solvent sample results, these analyses indicate that the solvent does not require Isopar® L trimming at this time. However, the addition of TiDG (suppressor) to the blended solvent is recommended. Evidence of possible (slight) isomerization of the solvent, probably Isopar®L or TiDG degradation products, was observed.

  4. Multigenerational effects of whole body exposure to 2.14 GHz W-CDMA cellular phone signals on brain function in rats.

    Shirai, Tomoyuki; Imai, Norio; Wang, Jianqing; Takahashi, Satoru; Kawabe, Mayumi; Wake, Kanako; Kawai, Hiroki; Watanabe, So-Ichi; Furukawa, Fumio; Fujiwara, Osamu

    2014-10-01

    The present experimental study was carried out with rats to evaluate the effects of whole body exposure to 2.14 GHz band code division multiple access (W-CDMA) signals for 20 h a day, over three generations. The average specific absorption rate (SAR, in unit of W/kg) for dams was designed at three levels: high (CDMA signals for 20 h/day did not cause any adverse effects on the F1 , F2 , and F3 offspring. PMID:25196377

  5. Structure, magnetic and thermo-mechanic properties of Ni2.14Mn0.81Fe0.05Ga Heusler alloy

    The influence of a strong magnetic field, single-axis pressure and intensive ultrasound on the process of structural (martensitic) transition on polycrystals of ferromagnetic alloy Ni2.14Mn0.81Fe0.05Ga with shape memory was studied experimentally. It is shown that magnetic field up to 8 T shifts without essential distortions the temperature hysteresis loop of martensitic transition to the range of higher temperatures, single-axis pressure blurs the martensitic transition, expanding the temperature hysteresis loop, while ultrasonic vibration may result in contraction of the hysteresis loop

  6. Distribution of radioactivities in sugars from acetate-2-14C incubation and elemental content of some vascular plants in two diverse habitats of Glacier Bay, Alaska

    Essentially six sugars became labeled following acetate-2-14C metabolism in plants distributed in two different communities--pioneer and forest. Of these the bulk of radio-activity resided in glucose, fructose and sucrose. Except for willows, labeled glucose and labeled fructose dominated the plants of the pioneer habitat, while labeled sucrose in addition to labeled glucose and fructose characterized those of the forest. For willows, the radioactivities were present in both monosaccharides and disaccharides. This sugar labeling pattern occurred in the alder which for the two habitats tested, was consistent with the general observation. The relative level of the content of magnesium and phosphorus for various plants in the pioneer habitat were no different from those in the forest habitat. Levels of sulfur, chlorine, potassium and calcium were generally higher in plants of the forest than in those of the pioneer community. Plants with a low level of K contained a higher level of labeled hexoses; while plants with a high level of K contained both labeled hexoses and disaccharide, indicating that potassium may be involved in the incorporation of the 14C into sugar during acetate-2-14C. (J.P.N.)

  7. Induction of monooxygenases and incorporation of radioactivity from 2-14C-lysine into hepatic microsomes of phenobarbital-treated rats fed a diet deficient in lysine, methionine, threonine and vitamine A, C and E

    The effect of diet on induction of monooxygenases and distribution of label from 2-14C-lysine in fractions of liver homogenate, muscle homogenate and blood of male rats treated with phenobarbital (80 mg/rg, three days) was studied. 2-14C-lysine was injected intraperitoneally 24 h before the first injection of phenobarbital. It was demonstrated that monooxygenase induction, increase of relative liver weight and incorporation of label from 2-14C-lysine into fractions of liver homogenate in phenobarbital-treated rats were more pronounced as compared with the similarly trated rats that were fed a balanced diet. The possibility of mobilization of deficient essential components to liver from other organs and tissues for maintenance of monooxygenase induction is discussed

  8. Induction of monooxygenases and incorporation of radioactivity from 2-14C-lysine into hepatic microsomes of phenobarbital-treated rats fed a diet deficient in lysine, methionine, threonine and vitamines A, C, E

    The effect of diet on induction of monooxygenases and distribution of radioactivity from 2-14C-lysine in fractions of liver homogenate, muscle homogenate and blood of male rats treated with phenobarbital was studied. 2-14C-lysin was injected intraperitoneally 24 h before the first injection of phenobarbital. It was demonstrated that monooxygenase induction, increase of relative liver weight and incorporation of radioactivity from 2-14C-lysine into fractions of liver homogenate in phenobarbital-treated rats fed diet deficient in lysine, methionine, threonine and vitamins A, C, E were more pronounced as compared with the similarly treated rats which were fed a balanced diet. The possibility of mobilization of deficient essencial components to liver from other organs and tissues for maintenance of monooxygenase induction iis discussed

  9. Overexpression of miR-214-3p in esophageal squamous cancer cells enhances sensitivity to cisplatin by targeting survivin directly and indirectly through CUG-BP1.

    Phatak, P; Byrnes, K A; Mansour, D; Liu, L; Cao, S; Li, R; Rao, J N; Turner, D J; Wang, J-Y; Donahue, J M

    2016-04-21

    Based on its marked overexpression in multiple malignancies and its roles in promoting cell survival and proliferation, survivin is an attractive candidate for targeted therapy. Toward this end, a detailed understanding of the mechanisms regulating survivin expression in different cancer cells will be critical. We have previously shown that the RNA-binding protein (RBP) CUG-BP1 is overexpressed in esophageal cancer cells and post-transcriptionally regulates survivin in these cells. The objective of this study was to investigate the role of microRNAs (miRs) in regulating survivin expression in esophageal cancer cells. Using miR expression profiling analysis, we found that miR-214-3p is one of the most markedly downregulated miRs in two esophageal squamous cancer cell lines compared with esophageal epithelial cells. Interestingly, using miR target prediction programs, both survivin and CUG-BP1 mRNA were found to contain potential binding sites for miR-214-3p. Forced expression of miR-214-3p in esophageal cancer cells leads to a decrease in the mRNA and protein levels of both survivin and CUG-BP1. This effect is due to decreased mRNA stability of both targets. By contrast, silencing miR-214-3p in esophageal epithelial cells leads to an increase in both survivin and CUG-BP1 mRNA and protein. To determine whether the observed effect of miR-214-3p on survivin expression was direct, mediated through CUG-BP1, or both, binding studies utilizing biotin pull-down assays and heterologous luciferase reporter constructs were performed. These demonstrated that the mRNA of survivin and CUG-BP1 each contain two functional miR-214-3p-binding sites as confirmed by mutational analysis. Finally, forced expression of miR-214-3p enhances the sensitivity of esophageal cancer cells to cisplatin-induced apoptosis. This effect is abrogated with rescue expression of survivin or CUG-BP1. These findings suggest that miR-214-3p acts as a tumor suppressor and that its downregulation contributes

  10. Low-temperature specific heat of BaCuO2 and BaCuO2.14 in magnetic fields to 7 T

    The specific heats of samples of BaCuO2 and BaCuO2.14, on which magnetization and/or neutron-diffraction measurements had been made earlier, were measured for the temperature range 0.35≤T≤30 K in magnetic fields to 7 T. BaCuO2+x has a complex structure with 90 formula units in a bcc unit cell; 6 Cu are ''lone spins,'' 48 are in 8 Cu6O12 ''ring clusters,'' and 36 are in 2 Cu18O24 ''sphere clusters.'' The ring and sphere clusters have ferromagnetically ordered ground states with spins S=3 and 9, respectively. Antiferromagnetic ordering of the ring clusters occurs with a Neel temperature TN(0)∼15 K. The specific heat of BaCuO2 shows a cooperative ordering anomaly associated with the antiferromagnetic ordering of the ring clusters. Schottky-like anomalies, having maxima at ∼5 and ∼0.7 K, are identified with the ordering of the sphere clusters and the lone spins, respectively. Only Schottky-like anomalies are observed for the specific heat of BaCuO2.14. It is suggested that the increase in the Cu oxidation state, due to the addition of 0.14 mol of O, increases Cu-O covalent bonding (spin compensation) and/or produces nonmagnetic Cu3+, which in addition to the known increase in the Cu-O bond lengths, disrupts the superexchange paths that lead to the antiferromagnetic ordering of the ring clusters in BaCuO2. For BaCuO2 the magnetic entropy was 90% of that predicted for the ordering of the three Cu structures. On the other hand, the magnetic entropy for BaCuO2.14 was only 65% of that predicted, which suggests a relative large suppression of some magnetic entities due to the addition of 0.14 mol of O. Although BaCuO2+x is an insulator, the specific heat has a T-proportional component that is magnetic field dependent and is presumably associated with the magnetic degrees of freedom. (c) 2000 The American Physical Society

  11. Saturation mutagenesis of Bradyrhizobium sp. BTAi1 toluene 4-monooxygenase at alpha-subunit residues proline 101, proline 103, and histidine 214 for regiospecific oxidation of aromatics.

    Yanık-Yıldırım, K Cansu; Vardar-Schara, Gönül

    2014-11-01

    A novel toluene monooxygenase (TMO) six-gene cluster from Bradyrhizobium sp. BTAi1 having an overall 35, 36, and 38 % protein similarity with toluene o-xylene monooxygenase (ToMO) of Pseudomonas sp. OX1, toluene 4-monooxygenase (T4MO) of Pseudomonas mendocina KR1, and toluene-para-monooxygenase (TpMO) of Ralstonia pickettii PKO1, respectively, was cloned and expressed in Escherichia coli TG1, and its potential activity was investigated for aromatic hydroxylation and trichloroethylene (TCE) degradation. The natural substrate toluene was hydroxylated to p-cresol, indicating that the new toluene monooxygenase (T4MO·BTAi1) acts as a para hydroxylating enzyme, similar to T4MO and TpMO. Some shifts in regiospecific hydroxylations were observed compared to the other wild-type TMOs. For example, wild-type T4MO·BTAi1 formed catechol (88 %) and hydroquinone (12 %) from phenol, whereas all the other wild-type TMOs were reported to form only catechol. Furthermore, it was discovered that TG1 cells expressing wild-type T4MO·BTAi1 mineralized TCE at a rate of 0.67 ± 0.10 nmol Cl(-)/h/mg protein. Saturation and site directed mutagenesis were used to generate eight variants of T4MO·BTAi1 at alpha-subunit positions P101, P103, and H214: P101T/P103A, P101S, P101N/P103T, P101V, P103T, P101V/P103T, H214G, and H214G/D278N; by testing the substrates phenol, nitrobenzene, and naphthalene, positions P101 and P103 were found to influence the regiospecific oxidation of aromatics. For example, compared to wild type, variant P103T produced four fold more m-nitrophenol from nitrobenzene as well as produced mainly resorcinol (60 %) from phenol whereas wild-type T4MO·BTAi1 did not. Similarly, variants P101T/P103A and P101S synthesized more 2-naphthol and 2.3-fold and 1.6-fold less 1-naphthol from naphthalene, respectively. PMID:25016343

  12. Inelastic stress-strain response of 2[1]/[4]Cr-1Mo steel under combined tension-torsion at 600 C

    The results of the third-phase activity of the Subcommittee on Inelastic Analysis and Life Prediction of High Temperature Materials, JSMS, are summarized in this series of papers.As the first part, the evaluation of inelastic constitutive models under plasticity-creep interaction conditions is presented in extension of the previous report of the phase 2 activity. Seven types of experiment were performed under multiaxial loading of tension and torsion with normalized and tempered 2[1]/[4]Cr-1Mo steel at 600 C: (i) step-up/down creep, (ii) uniaxial tension with strain rate change, (iii) cruciform stressing, (iv) biaxial mechanical ratcheting, (v) cyclic torsion, (vi) in-phase cyclic straining and (vii) out-of-phase cyclic straining. The experimental results of these benchmark tests are compared with the simulated results by seven types of constitutive models to evaluate their accuracy in simulating the experimental behaviour of the material. ((orig.))

  13. Effect of glutathione modulation of the distribution and transplacental uptake of 2-[14C]-chloroacetonitrile (CAN) quantitative whole-body autoradiographic study in pregnant mice.

    Jacob, S; Abdel-Aziz, A A; Shouman, S A; Ahmed, A E

    1998-01-01

    Chloroacetonitrile (CAN), a drinking water disinfectant by-product, has mutagenic and carcinogenic properties. CAN is known to deplete glutathione (GSH), and previous studies reported an enhanced molecular interaction of CAN after GSH depletion in the uterine and fetal tissues of mice. The present report may help to understand the potential mechanisms involved in such molecular interactions by examining the disposition, transplacental uptake and covalent interaction of the chemical in normal and GSH depleted pregnant mice (at 13th day of gestation). Both normal and GSH depleted (by administration of Diethylmaleate (DEM), 0.6 mL/kg, i.p.) pregnant mice were given an equitoxic i.v. dose of 2-[14C]-CAN(333 microCi/kg equivalent to 77 mg/kg). Animals were processed for whole-body autoradiography (WBA) at 1, 8 and 24 hr after treatment. Tissue distribution of radioactivity in the autoradiographs was quantitated using computer aided image analysis. With few exceptions, a rapid high uptake (at 1 hr) of radioactivity was observed in all major maternal (liver, lung, urinary bladder, gastrointestinal mucosa, cerebellum, uterine luminal fluid) and fetal (liver, brain) organs of both normal and GSH depleted mice. This pattern of distribution was observed, with lesser intensity, at 8 hr following treatment. At a later time period (24 hr), there was a significant higher retention and covalent interaction of radioactivity in GSH depleted mouse tissues especially in the liver as compared to normal mouse. This study suggests that 2-[14C]-CAN and/or its metabolites are capable of crossing the placental barrier. The observed higher uptake and retention of the radioactivity in the maternal liver, kidney, cerebellum, nasal turbinates and fetal liver may pose toxicity of the chemical to these organs. The increased covalent interaction of radioactivty in GSH depleted mice liver may indicate the potential utilization of GSH pathway by this organ in the detoxication of CAN derived

  14. Study of the background of the neutrinoless double β decay with the detector NEMO 2: contribution arising from the radon diffusion and internal pollution of the source 214Bi have been estimated

    The NEMO experiment is designed to understand the nature of the neutrino by studying the double beta decay of Mo-100 which is related to the Majorana neutrino effective mass. In this kind of experiment a good understanding of the different sources of background is crucial as only few events are expected per year at the required level of sensitivity. In this thesis we present the main theoretical and experimental aspects of the measurement of the neutrinoless double beta decay of Mo-100 with the prototype detector NEMO2. The goal of this study is to obtain a realistic interpretation of the few events detected at high energy in the two-electron channel as a background to neutrinoless double beta decay. In particular, the contribution arising from Bi-214 has been investigated. These events have been selected and analysed by means of the beta-alpha decays of Bi-214 into Pb-210. The events are characterized by a delayed track in the wire chamber and the corresponding signal is rather clean. The study has demonstrated the diffusion of Rn-222 into the detector and its contribution to Bi-214 pollution has been estimated. A measurement of the Bi-214 internal contamination of the source has been made as well as an estimation of the Bi-214 deposit due to Rn-222. As a result of this study it appears that, under the conditions of the NEMO2 experiment, the Bi and Rn contributions are of the same order of magnitude as the background induced at high energy by two-neutrino double beta decay. In conclusion, the backgrounds of the neutrinoless double beta decay of Mo-100 are well understood in the NEMO2 experiment leading to an extrapolation for the NEMO3 experiment. (authors)

  15. Study of the background of the neutrinoless double {beta} decay with the detector NEMO 2: contribution arising from the radon diffusion and internal pollution of the source {sup 214}Bi have been estimated; Etude du bruit de fond de la double-desintegration {beta} sans emission de neutrino dans le detecteur NEMO 2: contribution du radon ambiant et mesure de la pollution interne de la source en {sup 214}Bi

    Mauger, F.

    1995-02-01

    The NEMO experiment is designed to understand the nature of the neutrino by studying the double beta decay of Mo-100 which is related to the Majorana neutrino effective mass. In this kind of experiment a good understanding of the different sources of background is crucial as only few events are expected per year at the required level of sensitivity. In this thesis we present the main theoretical and experimental aspects of the measurement of the neutrinoless double beta decay of Mo-100 with the prototype detector NEMO2. The goal of this study is to obtain a realistic interpretation of the few events detected at high energy in the two-electron channel as a background to neutrinoless double beta decay. In particular, the contribution arising from Bi-214 has been investigated. These events have been selected and analysed by means of the beta-alpha decays of Bi-214 into Pb-210. The events are characterized by a delayed track in the wire chamber and the corresponding signal is rather clean. The study has demonstrated the diffusion of Rn-222 into the detector and its contribution to Bi-214 pollution has been estimated. A measurement of the Bi-214 internal contamination of the source has been made as well as an estimation of the Bi-214 deposit due to Rn-222. As a result of this study it appears that, under the conditions of the NEMO2 experiment, the Bi and Rn contributions are of the same order of magnitude as the background induced at high energy by two-neutrino double beta decay. In conclusion, the backgrounds of the neutrinoless double beta decay of Mo-100 are well understood in the NEMO2 experiment leading to an extrapolation for the NEMO3 experiment. (authors).

  16. A Strategy for Interpretation of Microearthquake Tomography Results in the Salton Sea Geothermal Field Based upon Rock Physics Interpretations of State 2-14 Borehole Logs

    Bonner, B; Hutchings, L; Kasameyer, P

    2006-06-14

    We devise a strategy for analysis of Vp and Vs microearthquake tomography results in the Salton Sea geothermal field to identify important features of the geothermal reservoir. We first interpret rock properties in State 2-14 borehole based upon logged core through the reservoir. Then, we interpret seismic recordings in the well (Daley et al., 1988) to develop the strategy. We hypothesize that mapping Poisson's ratio has two applications for the Salton Sea geothermal reservoir: (1) to map the top of the reservoir, and (2) as a diagnostic for permeable zones. Poisson's ratio can be obtained from Vp and Vs. In the State 2-14 borehole, Poisson's ratio calculated from large scale averages ({approx} 150 m) shows a monotonic decrease with depth to about 1300 m, at which point it increases with depth. Our model is that the monotonic decrease is due to compaction, and the increase below 1300 m is due to the rocks being hydrothermally altered. We hypothesize we can map the depth to alteration by identifying the transition from decreasing to increasing values; and thus, map the top of the reservoir, which is associated with a known increase in sulfite, chlorite, and epidote alteration that may be indicative of hydrothermal activity. We also observe (from Daley et. al. plots) an anomalous drop in Poisson's ratio at a depth of about 900 m, within a sandstone formation. The sandstone has a P-wave velocity significantly higher than the siltstone above it but a lower velocity in the lower half of the formation relative to the upper half. We interpret the relative decrease in velocity to be due to fracturing and chemical alteration caused by permeability. We conclude that using Vp and Vs tomography results to obtain images of Poisson's ratio has the potential to identify significant features in the geothermal reservoir in this geologic setting. Seismic attenuation tomography results (mapped as Qp and Qs) should also be useful for evaluating geothermal

  17. The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives

    Ottaviani, Javier I.; Borges, Gina; Momma, Tony Y.; Spencer, Jeremy P. E.; Keen, Carl L.; Crozier, Alan; Schroeter, Hagen

    2016-01-01

    Diet is a major life style factor affecting human health, thus emphasizing the need for evidence-based dietary guidelines for primary disease prevention. While current recommendations promote intake of fruit and vegetables, we have limited understanding of plant-derived bioactive food constituents other than those representing the small number of essential nutrients and minerals. This limited understanding can be attributed to some extent to a lack of fundamental data describing the absorption, distribution, metabolism and excretion (ADME) of bioactive compounds. Consequently, we selected the flavanol (−)-epicatechin (EC) as an example of a widely studied bioactive food constituent and investigated the ADME of [2-14C](−)-epicatechin (300 μCi, 60 mg) in humans (n = 8). We demonstrated that 82 ± 5% of ingested EC was absorbed. We also established pharmacokinetic profiles and identified and quantified >20 different metabolites. The gut microbiome proved to be a key driver of EC metabolism. Furthermore, we noted striking species-dependent differences in the metabolism of EC, an insight with significant consequences for investigating the mechanisms of action underlying the beneficial effects of EC. These differences need to be considered when assessing the safety of EC intake in humans. We also identified a potential biomarker for the objective assessment of EC intake that could help to strengthen epidemiological investigations. PMID:27363516

  18. Novel PSEN1 mutations (H214N and R220P) associated with familial Alzheimer's disease identified by targeted exome sequencing.

    Piccoli, Elena; Rossi, Giacomina; Rossi, Tommaso; Pelliccioni, Giuseppe; D'Amato, Ilaria; Tagliavini, Fabrizio; Di Fede, Giuseppe

    2016-04-01

    Autosomal dominant Alzheimer's disease (AD) is caused by mutations in amyloid precursor protein, presenilin 1 (PSEN1), and presenilin 2 genes and is mostly associated with early-onset form of AD (EOAD), whereas very few mutations were also found in late-onset AD (LOAD) cases. Because of the clinical overlapping between AD and other degenerative dementias such as frontotemporal dementias, a wide-spectrum genetic analysis should be envisaged in the differential diagnosis of this group of disorders. We used next-generation sequencing techniques to analyze 10 genes involved in dementia on a cohort of 20 EOAD and 20 LOAD cases. We found 5 rare coding variants (frequency PSEN1 H214N mutation, identified in a case of familial EOAD and PSEN1 R220P, found in a case of familial LOAD, are predicted to be pathogenic. These findings confirm the contribution of PSEN1 genetic variants also to LOAD, underlining the need of extending the genetic screening of presenilin mutations to LOAD patients. Two variants in microtubule-associated protein tau and 1 in progranulin appeared to be benign polymorphisms, showing no major contribution of these genes to AD. PMID:26925509

  19. Selective removal of Ag+ ions from nitric acid medium by alginate microcapsules, Lewatite TP 214 chelating resin, and 200 CT strongly acidic ion exchanger

    Alginate microcapsules containing bis (2, 4, 4-trimethylpenthyl) monothiophosphinic acid (Cyanex 302) were prepared for the selective removal of Ag+ ions from the reprocessing effluents of FBR-MOX fuel. The Ag+ ions are added for the adjustment of oxidation state of Plutonium. We compared uptake properties of aforementioned microcapsules with those of 200 CT a strongly acidic resin, and Lewatite TP 214, a very selective chelating resin for the Ag+ ions. Most of the uptake properties of the microcapsules were amid the 200 CT and Lewatite, and rather similar to the later. The order of uptake kinetic and breakthrough capacity were the same as: 200 CT > Microcapsules > Lewatite; and for selectivity: Lewatite > Microcapsules > 200 CT. However, high selectivity of Lewatite is rather disadvantageous because it makes the elution operation complicated. Advantages of microcapsules include simple preparation procedure, relatively high selectivity and ease of elution even with 3M nitric acid. However, their total capacity is low. For enhancing the total capacity only increasing the active component is not enough since it deteriorates the kinetics, and the new preparation techniques are necessary which are under study. (author)

  20. Role of tele-medicine in retinopathy of prematurity screening in rural outreach centers in India - a report of 20,214 imaging sessions in the KIDROP program.

    Vinekar, Anand; Jayadev, Chaitra; Mangalesh, Shwetha; Shetty, Bhujang; Vidyasagar, Dharmapuri

    2015-10-01

    Middle-income countries such as India are suffering from the third epidemic of retinopathy of prematurity (ROP). Improved survival and lower infant mortality rates have resulted in an increased number of preterm survivors in rural areas that unfortunately lack ROP specialists. We report our experience of a public-private partnership in rural India of an ongoing telemedicine program Karnataka Internet Assisted Diagnosis of Retinopathy of Prematurity program KIDROP that provides ROP screening by non-physicians. The analysis of 20,214 imaging sessions of 7106 from 36 rural centers in 77 months of activity are presented. The overall incidence of any stage and treatment requiring ROP was 22.39% and 3.57% respectively. We found a higher incidence of severe ROP in private (7.1%) vs government centers (1.7%). Fifty of the 254 babies (19.69%) who underwent treatment were outside the American screening guidelines cut-off. The report compares other "real-world" tele-ROP programs, summarizes the impact, and provides future strategies for outreach ROP screening in middle-income countries. PMID:26092301

  1. Planck intermediate results. VI: The dynamical structure of PLCKG214.6+37.0, a Planck discovered triple system of galaxy clusters

    Ade, P A R; Arnaud, M; Ashdown, M; Atrio-Barandela, F; Aumont, J; Baccigalupi, C; Balbi, A; Banday, A J; Barreiro, R B; Bartlett, J G; Battaner, E; Benabed, K; Benoît, A; Bernard, J -P; Bersanelli, M; Bhatia, R; Böhringer, H; Bonaldi, A; Bond, J R; Borrill, J; Bouchet, F R; Bourdin, H; Burigana, C; Cabella, P; Cardoso, J -F; Castex, G; Catalano, A; Cayón, L; Chamballu, A; Chiang, L -Y; Chon, G; Christensen, P R; Clements, D L; Colafrancesco, S; Colombi, S; Colombo, L P L; Comis, B; Coulais, A; Crill, B P; Cuttaia, F; Da Silva, A; Dahle, H; Danese, L; Davis, R J; de Bernardis, P; de Gasperis, G; de Zotti, G; Delabrouille, J; Diego, J M; Dolag, K; Dole, H; Donzelli, S; Doré, O; Dörl, U; Douspis, M; Dupac, X; Efstathiou, G; Enßlin, T A; Eriksen, H K; Finelli, F; Flores-Cacho, I; Forni, O; Frailis, M; Franceschi, E; Frommert, M; Galeotta, S; Ganga, K; Génova-Santos, R T; Giard, M; Gilfanov, M; Giraud-Héraud, Y; González-Nuevo, J; Górski, K M; Gregorio, A; Gruppuso, A; Hansen, F K; Harrison, D; Heinämäki, P; Hempel, A; Henrot-Versillé, S; Hernández-Monteagudo, C; Herranz, D; Hildebrandt, S R; Hivon, E; Hobson, M; Holmes, W A; Hurier, G; Jaffe, T R; Jaffe, A H; Jagemann, T; Jones, W C; Juvela, M; Keihänen, E; Kisner, T S; Kneissl, R; Knoche, J; Knox, L; Kunz, M; Kurki-Suonio, H; Lagache, G; Lähteenmäki, A; Lamarre, J -M; Lasenby, A; Lawrence, C R; Jeune, M Le; Leonardi, R; Lilje, P B; López-Caniego, M; Luzzi, G; Macías-Pérez, J F; Maino, D; Mandolesi, N; Maris, M; Marleau, F; Marshall, D J; Martínez-González, E; Masi, S; Massardi, M; Matarrese, S; Mazzotta, P; Mei, S; Melchiorri, A; Melin, J -B; Mendes, L; Mennella, A; Mitra, S; Miville-Deschênes, M -A; Moneti, A; Montier, L; Morgante, G; Mortlock, D; Munshi, D; Murphy, J A; Naselsky, P; Nati, F; Natoli, P; Nørgaard-Nielsen, H U; Noviello, F; Osborne, S; Pajot, F; Paoletti, D; Pasian, F; Patanchon, G; Perdereau, O; Perotto, L; Perrotta, F; Piacentini, F; Piat, M; Pierpaoli, E; Piffaretti, R; Plaszczynski, S; Pointecouteau, E; Polenta, G; Ponthieu, N; Popa, L; Poutanen, T; Pratt, G W; Prunet, S; Puget, J -L; Rachen, J P; Rebolo, R; Reinecke, M; Remazeilles, M; Renault, C; Ricciardi, S; Riller, T; Ristorcelli, I; Rocha, G; Roman, M; Rosset, C; Rossetti, M; Rubiño-Martín, J A; Rusholme, B; Sandri, M; Savini, G; Scott, D; Smoot, G F; Starck, J -L; Sudiwala, R; Sunyaev, R; Sutton, D; Suur-Uski, A -S; Sygnet, J -F; Tauber, J A; Terenzi, L; Toffolatti, L; Tomasi, M; Tristram, M; Tuovinen, J; Valenziano, L; Van Tent, B; Vielva, P; Villa, F; Vittorio, N; Wade, L A; Wandelt, B D; Welikala, N; Yvon, D; Zacchei, A; Zaroubi, S; Zonca, A

    2012-01-01

    The survey of galaxy clusters performed by Planck through the Sunyaev-Zeldovich effect has already discovered many interesting objects, thanks to the whole coverage of the sky. One of the SZ candidates detected in the early months of the mission near to the signal to noise threshold, PLCKG214.6+37.0, was later revealed by XMM-Newton to be a triple system of galaxy clusters. We have further investigated this puzzling system with a multi-wavelength approach and we present here the results from a deep XMM-Newton re-observation. The characterisation of the physical properties of the three components has allowed us to build a template model to extract the total SZ signal of this system with Planck data. We partly reconciled the discrepancy between the expected SZ signal from X-rays and the observed one, which are now consistent at less than 1.2 sigma. We measured the redshift of the three components with the iron lines in the X-ray spectrum, and confirmed that the three clumps are likely part of the same superclus...

  2. Study on the corrosion by the liquid sodium of SUS 321 steel, SUS 304 steel and 21/4Cr-1Mo steel by using the small sodium loop

    Liquid sodium is used as the coolant for liquid metal fast breeder reactor. The 21/4Cr-1Mo steel is used as structural material for evaporator and SUS F321 steel is used for super heater of steam generator of 'Monju', a prototype fast breeder reactor in Japan. The trial manufacture of small sodium loop made of SUS 316 steel and a study on the sodium corrosion of explosive plugged part are already reported by us. Study on the sodium corrosion of arc welded part of SUS 321 steel, SUS 304 steel and 21/4Cr-1Mo steel is reported in this paper. Measurement of weight loss and analysis by X-ray photoelectron spectrum are conducted for the corroded specimen. Effect of welding on the corrosion characteristic of these materials is not evidently observed. (author)

  3. Corrective Action Investigation Plan for Corrective Action Unit 214: Bunkers and Storage Areas Nevada Test Site, Nevada: Revision 0, Including Record of Technical Change No. 1 and No. 2

    U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

    2003-05-16

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 214 under the Federal Facility Agreement and Consent Order. Located in Areas 5, 11, and 25 of the Nevada Test Site, CAU 214 consists of nine Corrective Action Sites (CASs): 05-99-01, Fallout Shelters; 11-22-03, Drum; 25-99-12, Fly Ash Storage; 25-23-01, Contaminated Materials; 25-23-19, Radioactive Material Storage; 25-99-18, Storage Area; 25-34-03, Motor Dr/Gr Assembly (Bunker); 25-34-04, Motor Dr/Gr Assembly (Bunker); and 25-34-05, Motor Dr/Gr Assembly (Bunker). These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). The suspected contaminants and critical analyte s for CAU 214 include oil (total petroleum hydrocarbons-diesel-range organics [TPH-DRO], polychlorinated biphenyls [PCBs]), pesticides (chlordane, heptachlor, 4,4-DDT), barium, cadmium, chronium, lubricants (TPH-DRO, TPH-gasoline-range organics [GRO]), and fly ash (arsenic). The land-use zones where CAU 214 CASs are located dictate that future land uses will be limited to nonresidential (i.e., industrial) activities. The results of this field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the corrective action decision document.

  4. Quantification of ineffective erythropoiesis in megaloblastic anaemia by determination of endogenous production of 14CO after administration of glycine-2-14C

    The determination of the early peak of 14CO production that results from haem turnover after administration of glycine-2-14C was studied in patients with pernicious anaemia. The accuracy of this technique in measuring ineffective erythropoiesis was assessed by comparison with other measurements of the severity of the disease. 6 patients were studied before specific treatment and 2 of these also after treatment. The endogenous production of 14CO was calculated from determinations of the production of CO by a rebreathing technique and of the specific activity of CO washed out from the body CO store by oxygen breathing. The early labelled peak was increased 7-39 times compared to that in healthy control subjects and represented 35-86% of the total production of 14CO as compared to 13% in controls. The early labelled peak was significantly correlated to the Hb concentration, mean red cell volume and endogenous production of CO. 2 patients, twice examined, showed a moderately increased early labelled peak also after specific treatment. This was attributed to persistence of some ineffective erythropoiesis in 1 patient and possibly increased hepatic haem turnover in the other. The magnitude of the early labelled peak and the maximal activity of 14CO found in the samples of CO collected from the body CO store were significantly correlated. In conclusion, with the present method the early peak of 14CO reflected the ineffective erythropoiesis in patients with pernicious anaemia. The early labelled peak could be predicted from the maximal activity of 14CO found in the samples of CO washed out from the body CO store. (author)

  5. Regional changes in brain 2-14C-deoxyglucose uptake induced by convulsant and non-convulsant doses of lindane

    Lindane-induced dose- and time-related changes in regional 2-14C-deoxyglucose (2-DG) uptake were examined in 59 discrete rat brain structures using the 2-DG autoradiographic technique. At different times (0.5-144 hr) after administration of a seizure-inducing single dose of lindane (60 mg/kg), 2-DG uptake was significantly increased in 18 cortical and subcortical regions mainly related to the limbic system (e.g., Ammon's horn, dentate gyrus, septal nuclei, nucleus accumbens, olfactory cortex) and extrapyramidal and sensory-motor areas (e.g., cerebellar cortex, red nucleus, medial vestibular nucleus). There was also a significant increase in superior colliculus layer II. In addition, significant decreases occurred in a group of 6 regions (e.g., auditory and motor cortices). Non-convulsing animals treated with the same dose of lindane showed a regional pattern of 2-DG uptake less modified than the convulsant group. A non-convulsant single dose of lindane (30 mg/kg) also modified significantly the 2-DG uptake (0.5-24 hr) in some brain areas. Although the various single doses of lindane tested produced different altered patterns of brain 2-DG uptake, some structures showed a similar trend in their modification (e.g., superior colliculi and accumbens, raphe and red nuclei). Repeated non-convulsant doses of lindane produced defined and long-lasting significant elevations of 2-DG uptake in some subcortical structures. Considering the treated groups all together, 2-DG uptake increased significantly in 26 of the 59 regions examined but only decreased significantly in 9 of them during the course of lindane effects. This fact can be related to the stimulant action described for this neurotoxic agent. The observed pattern provides a descriptive approach to the functional alterations occurring in vivo during the course of lindane intoxication

  6. Sõpruse pst. 214 / Ilme Trepp

    Trepp, Ilme

    2002-01-01

    Rööptekst vene k. lk. 33-34. Ühistute huvide eest seismiseks loodi Mustamäe Korteriühistute Nõukoda, mis seab eesmärgiks esindada Mustamäe korteriühistuid, teha koostööd linnavalitsusega, vahetada infot ja kasulikke kogemusi

  7. 21.4.Mental deficiency

    1993-01-01

    930413 Clinlcal study of mental disorders inpost—stroke patients.WANG Huanlin (王焕林),et al.102nd Hosp,PLA Changzhou,213003.Chin J Nerv & Ment Dis 1992;18(5):281—283.The mental disorder has been studied bymeans of DSM-Ⅱ diagnostic criteria in 104hospitalized stroke patients.The results re-vealed that the prevalence of mental disorderwas 46.2% in post-stroke patients.Theprevalence of poststroke depression (PSD),de-pressive neurosis (DN),multiple infarct demen-tia (MID),and post—stroke mania (PSM) were22.1%,11.5%,8.7%,and 3(?)8% respectively.It was indicated that the lesions of frontal cortexand left basal ganglia were strongly associated

  8. 青春期前女童外阴阴道炎4214例临床分析%Clinical analysis of 4 214 prepubertal girls with vulvovaginitis

    林翠兰; 何冰洁; 陈昂; 何婉懿; 韦婉俭

    2014-01-01

    目的 分析青春期前女童外阴阴道炎年龄分布、就诊原因、高危因素及病因种类分布特征.方法 回顾性分析总结2010年1月至2013年6月在中山市博爱医院女童专科门诊诊断外阴阴道炎并已建立专科档案的4 214例青春期前患儿临床资料,所有临床资料来自于所建专科病历档案.结果 (1)发病与年龄的关系:0 ~1岁1 587例(37.7%),>1 ~3岁954例(22.6%),>3 ~7岁1 289例(30.6%),>7岁384例(9.1%);(2)不良因素与患病的关系:不良卫生习惯2 924例(69.4%),过敏史和最近过敏原接触史875例(20.8%);(3)有、无症状患儿与发生情况:体检发现女童外阴阴道炎无症状者919例(21.8%);有症状者3 295例(78.2%):阴道分泌物812例(19.3%),外阴发红725例(17.2%),瘙痒636例(15.1%),尿频/尿急/尿痛532例(12.6%),外阴疼痛240例(5.7%),外阴异味198例(4.7%),排尿困难152例(3.6%);(4)疾病或病因分类与年龄的关系:非特异性外阴阴道炎1 771例(42.0%),阴唇粘连1 309例(31.1%),细菌性外阴阴道炎375例(8.9%),过敏性外阴阴道炎266例(6.3%),情感性交叉擦腿动作266例(6.3%).结论 儿童不良卫生习惯、过敏及不良排尿习惯等是外阴阴道炎的主要相关因素,好发于婴幼儿期和学龄前期;而过敏及情感性交叉擦腿动作是反复发生和引起非特异性外阴阴道炎及阴唇粘连的主要病因.重视女童生殖器卫生,防治各类外阴阴道炎,可减少女童青春期前外阴阴道炎的发生.%Objective To explore the distribution of age,reasons for treatment,risk factors,and causes of vulvovaginitis in prepubertal girls.Methods A total of 4 214 prepubertal girls with vulvovaginitis who were admitted to the Girl's Sub-department,Zhongshan Boai Hospital from January 2010 to June 2013 was reviewed retrospectively.All clinical data were from medical records with files.Results Atotalof1 587 patients (37.7%) was0to1 years old,954 (22

  9. The effect of low temperature, nitrogen atmosphere and uncouplers on longitudinal distribution of radioactivity after acropetal and basipetal application of (2-14C) ABA in long root segments of Phaseolus coccineus L

    Acropetal movement of [2-14C] abscisic acid (ABA) in long root segments of P.coccineus is drastically reduced by destruction of the tissue, low temperature, anaerobic conditions and pretreatment with CCCP (carbonyl-cyanide-m-chloro-phenylhydrazone) at uncoupling concentrations. Basipetal transport is not affected by destruction of the tissue but markedly inhibited by the other treatments. Consequently polarity of ABA-transport disappears only after the roots have been killed. The importance of using long segments for hormone transport studies is discussed. (orig.)

  10. The identification of soil radionuclides in the area of Puspiptek and surrounding

    The area of PUSPIPTEK and the surrounding are potentially exposed by radionuclides, because the operation of the nuclear research plant. The PPTN Serpong was operated long than 10 years, therefore soil radioactivity need to evaluate. The determination of radioactivity in the soil samples which be taken from research location using gamma spectrometry on June-August. The result of the research identified natural radionuclides K-40; Thorium decay series Ac-228, Bi-212, Pb-212, Tl-208, Ra-224 and Rn-220; Uranium decay series Bi-214, Pa-234, Pb-214 and Actinium decay series Bi-211, Po-211. There are no identification radionuclides produce from the activation of PPTN Serpong

  11. Transport and distribution of basally applied indoleaceticacid-2-14C in bean (Phaseolus vulgaris L.) cuttings in relation to interaction of auxin and indole in adventitious root formation

    Negative interaction or antagonism between IAA and high concentration of indole in rooting of bean cuttings was associated with significant increase in upward movement and accumulation of radiocarbon of IAA-2-14C in upper parts of the cuttings. Positive interaction or synergism observed with lower concentrations of indole was not associated with such increased acropetal transport. There was also no significant difference in total radioactivity per cutting among the different concentrations of indole. The results suggest that non-promotion of upward movement of basally applied auxin from the root forming region or its increased upward movement out of the root forming region may be an important factor in the mechanism of synergism or antagonism respectively. (author)

  12. Clinical observation of gastric bypass in treatment of patients with type 2 diabetes mellitus%胃转流术治疗2型糖尿病的临床疗效:附214例报告

    郭渝明; 李广阔; 霍芊竹; 陈俊; 邓开

    2013-01-01

      目的Roux-en-Y式胃转流术(RY-GBP)是2型糖尿病患者接受外科手术治疗的主要术式之一。本研究旨在进一步验证RY-GBP的手术治疗效果。方法214例2型糖尿病(T2DM)患者均行RY-GBP术,术中根据体质指数和胰岛素抵抗情况,选择合适的残胃(Pouch)容积和空肠袢长度。患者于术前和术后3,6,12个月行OGTT试验,并测定空腹血清胰岛素(FIns)、空腹血清C肽(FC-P)、糖化血红蛋白(HbAlc)、体重指数(BMI),密切关注患者术后的降糖药服用情况及糖尿病并发症改善情况。结果214例患者中,51例(23.8%)术后出院时即达治愈标准,停用降糖药物,78例(36.4%)于术后0~3个月内停药,21例(9.8%)于术后3~6个月内停药,18例(8.4%)于术后6~12个月内停药。另外46例(21.5%)12个月后仍服用降糖药物,但药物剂量有不同程度地减少,尚在进一步观察中。上述病例在术后3,6,12个月的各项检测指标均有所改善,近期治愈率达78.5%(168/214)。本组无死亡病例,相关并发症包括吻合口出血2例,吻合口溃疡7例,胃瘫21例,营养不良3例,贫血8例,在给予相应治疗后均缓解。结论RY-GBP胃转流术对肥胖型和非肥胖型2型糖尿病均有良好治疗效果,对非肥胖型2型糖尿病的治疗效果更值得进一步深入研究。%  Objective Gastric bypass(GBP), especially Roux-en-Y, is the main surgical procedure in patients with type 2 diabetes mellitus(T2DM). The present study focused on the evaluation of efficiency of Roux-en-Y Gastric bypass(RY-GBP) in T2DM patients. Methods Two hundred and fourteen patients with T2DM were operated according to the RY-GBP procedures, and gastric pouch as well as Roux limb were selected respectively by the BMI and insulin resistance. Blood glucose alterations(OGTT), Fins, FC-P, HbAlc, BMI, related complications and anti-sugar drugs were observed at

  13. Use of [2-14C]mevalonate and saponin-bound [14C]-3-hydroxy-3-methylglutaric acid for the biosynthesis of terpenoids in leaves of Dioscorea deltoidea

    After the introduction of [2-14C]acetate into leaves of Dioscorea deltoidea, a radioactive furonanalog of deltafolin - protodeltofolin, containing two-thirds of the label in the 3-hydroxy-3-methylglutaryl portion - was isolated from them. Radioactive β-careotene and sterols were isolated from cut young leaves of Dioscorea 24 h after the introduction of [14C] protodeltofolin into them, using chromatography on a column of silica gel and precipitation of sterols in the form of digitonins for this purpose. The incorporation of radioactivity from [14C]-3-hydroxy-3-methyl-glutaric acid, bound in the form of a saponin, and β-carotene came to 0.18-0.80%, while incorporation into sterols came to 0.07-2.86% of the radioactivity of the alcohol extract. Thereby it was shown that 3-hydroxyl-3-methylglutaric acid, bound in the form of the saponin, can be used to form terpenoids in Dioscorea leaves. It was suggested that the binding of hydroxymethylglutaric acid to saponin represents one of the mechanisms of regulation of the rate of terpenoid biosynthesis in Dioscorea leaves

  14. Paleomagnetism of Basaltic Lava Flows in Coreholes ICPP 213, ICPP-214, ICPP-215, and USGS 128 Near the Vadose Zone Research Park, Idaho Nuclear Technology and Engineering Center, Idaho National Engineering and Environmental Laboratory, Idaho

    Champion, Duane E.; Herman, Theodore C.

    2003-01-01

    A paleomagnetic study was conducted on basalt from 41 lava flows represented in about 2,300 ft of core from coreholes ICPP-213, ICPP-214, ICPP-215, and USGS 128. These wells are in the area of the Idaho Nuclear Technology and Engineering Center (INTEC) Vadose Zone Research Park within the Idaho National Engineering and Environmental Laboratory (INEEL). Paleomagnetic measurements were made on 508 samples from the four coreholes, which are compared to each other, and to surface outcrop paleomagnetic data. In general, subhorizontal lines of correlation exist between sediment layers and between basalt layers in the area of the new percolation ponds. Some of the basalt flows and flow sequences are strongly correlative at different depth intervals and represent important stratigraphic unifying elements. Some units pinch out, or thicken or thin even over short separation distances of about 1,500 ft. A more distant correlation of more than 1 mile to corehole USGS 128 is possible for several of the basalt flows, but at greater depth. This is probably due to the broad subsidence of the eastern Snake River Plain centered along its topographic axis located to the south of INEEL. This study shows this most clearly in the oldest portions of the cored sections that have differentially subsided the greatest amount.

  15. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228

    The activities of 228Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide 228Ac. The radium was pre-concentrated on MnO2 and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter 228Ra(228Ac), the daughter nuclide 228Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by 228Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9±0.1% was measured for 228Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317±0.013 cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1 g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of 228Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for 228Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure 228Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used

  16. Linear free energy relationship applied to trivalent cations with lanthanum and actinium oxide and hydroxide structure

    Linear free energy relationships for trivalent cations with crystalline M2O3 and, M(OH)3 phases of lanthanides and actinides were developed from known thermodynamic properties of the aqueous trivalent cations, modifying the Sverjensky and Molling equation. The linear free energy relationship for trivalent cations is as ΔGf,MvX0=aMvXΔGn,M3+0+bMvX+βMvXrM3+, where the coefficients aMvX, bMvX, and βMvX characterize a particular structural family of MvX, rM3+ is the ionic radius of M3+ cation, ΔGf,MvX0 is the standard Gibbs free energy of formation of MvX and ΔGn,M3+0 is the standard non-solvation free energy of the cation. The coefficients for the oxide family are: aMvX=0.2705, bMvX=-1984.75 (kJ/mol), and βMvX=197.24 (kJ/molnm). The coefficients for the hydroxide family are: aMvX=0.1587, bMvX=-1474.09 (kJ/mol), and βMvX=791.70 (kJ/molnm).

  17. Actinium: A RESTful Runtime Container for Scriptable Internet of Things Applications

    Kovatsch, Matthias; Lanter, Martin; Duquennoy, Simon

    2012-01-01

    Programming Internet of Things (IoT) applications is challenging because developers have to be knowledgeable in various technical domains, from low-power networking, over embedded operating systems, to distributed algorithms. Hence, it will be challenging to find enough experts to provide software for the vast number of expected devices, which must also be scalable and particularly safe due to the connection to the physical world. To remedy this situation, we propose an architecture that pr...

  18. Reflection asymmetry in odd-A and odd-odd actinium nuclei

    Theoretical calculations and measurements indicate that octupole correlations are at a maximum in the ground states of the odd-proton nuclei Ac and Pa. It has been expected that odd-odd nuclei should have even larger amount of octupole-octupole correlations. We have recently made measurements on the structure of 224Ac. Although spin and parity assignments could not be made, two bands starting at 354.1 and 360.0 keV have properties characteristic of reflection asymmetric shape. These two bands have very similar rotational constants and also similar alpha decay rates, which suggest similarity between the wavefunctions of these bands. These signatures provide evidence for octupole correlations in these nuclides

  19. Bestimmung der Ionisationsenergie von Actinium und Ultraspurenanalyse von Plutonium mit resonanter Ionisationsmassenspektrometrie (RIMS)

    Waldek, Achim Marcus

    2001-01-01

    ZusammenfassungDie Resonanzionisationsmassenspektrometrie (RIMS) verbindet hohe Elementselektivität mit guter Nachweiseffizienz. Aufgrund dieser Eigenschaften ist die Methode für Ultraspurenanalyse und Untersuchungen an seltenen oder schwer handhabbaren Elementen gut geeignet. Für RIMS werden neutrale Atome mit monochromatischem Laserlicht ein- oder mehrfach resonant auf energetisch hoch liegende Niveaus angeregt und anschließend durch einen weiteren Laserstrahl oder durch ein elektrisches Fe...

  20. Synthesis of chelating agents for actinium 225 complexation and its application in radioimmunotherapy

    Immunotherapy with radiolabeled antibodies should allow fairly specific targeting of certain cancers. However, iodine 131 may not be the best isotope for tumor therapy because of its limited specific activity, low beta-energy, relatively long half life and strong gamma emission. Another approach to improve therapeutic efficacy is the use of replacement isotopes with better physical properties. Chelator that can hold radio-metals with high stability under physiological conditions are essential to avoid excessive damage to non-target cells; Moreover, the development of new bifunctional chelating agents is essential for this purpose. Accordingly, our efforts have been directed, for several years, to the synthesis of original chelating agents likely to form stable complexes in vivo with the numerous potential candidates for such applications. Therefore, we have developed a new simple and efficient synthesis pathway of 2-(4-iso-thio-cyanate-benzyl)-1,4,7,10,13,16- hexa-aza-cyclo-hexadecane- 1,4,7,10,13,16-hexa-acetic acid, though functionalized on the cycle by a termination allowed coupling to an antibody or any other biological substance such as a hapten. (author)

  1. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    A technique of selenium purification from 232Th, 238U, 226,228Ra, 227Ac and 40K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  2. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    Rakhimov, A.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz); Warot, G. [CEA-CNRS, Modane (France). Laboratoire Souterrain de Modane (LSM); Karaivanov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Institute for Nuclear Research and Nuclear Energy (INRNE), Sofia (Bulgaria); Kochetov, O.I.; Lebedev, N.A.; Filosofov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Mukhamedshina, N.M.; Sadikov, I.I. [Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz)

    2013-07-01

    A technique of selenium purification from {sup 232}Th, {sup 238}U, {sup 226,228}Ra, {sup 227}Ac and {sup 40}K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  3. New method for large scale production of medically applicable Actinium-225 and Radium-223

    Alpha-emitters (211At, 212Bi, 213Bi, 223Ra, 225Ac) are promising for targeted radiotherapy of cancer. Only two alpha decays near a cell membrane result in 50% death of cancer cell and only a single decay inside the cell is required for this. 225Ac may be used either directly or as a mother radionuclide in 213Bi isotope generator. Production of 225Ac is provided by three main suppliers - Institute for Transuranium Elements in Germany, Oak Ridge National Laboratory in USA and Institute of Physics and Power Engineering in Obninsk, Russia. The current worldwide production of 225Ac is approximately 1.7 Ci per year that corresponds to only 100-200 patients that could be treated annually. The common approach for 225Ac production is separation from mother 229Th or irradiation of 226Ra with protons in a cyclotron. Both the methods have some practical limitations to be applied routinely. 225Ac can be also produced by irradiation of natural thorium with medium energy protons . Cumulative cross sections of 225Ac, 227Ac, 227Th, 228Th formations have been obtained recently. Thorium targets (1-9 g) were irradiated by 114-91 MeV proton beam (1-50 μA) at INR linear accelerator. After dissolution in 8 M HNO3 + 0.004 M HF thorium was removed by double LLX by HDEHP in toluene (1:1). Ac and REE were pre-concentrated and separated from Ra and most fission products by DGA-Resin (Triskem). After washing out by 0.01 M HNO3 Ac was separated from REE by TRU Resin (Triskem) in 3 M HNO3 media. About 6 mCi 225Ac were separated in hot cell with chemical yield 85%. The method may be upscaled for production of Ci amounts of the radionuclide. The main impurity is 227Ac (0.1% at the EOB) but it does not hinder 225Ac from being used for medical 225Ac/213Bi generators. (author)

  4. 4 CFR 21.4 - Protective orders.

    2010-01-01

    ... material, as well as other information the release of which could result in a competitive advantage to one... the applicant is not involved in competitive decision-making for any firm that could gain a competitive advantage from access to the protected information and that there will be no significant risk...

  5. 24 CFR 214.303 - Performance criteria.

    2010-04-01

    ... mortgage lenders, brokers, builders, or real estate sales agents or brokers in which the officer, employee... referring a client to mortgage lenders, brokers, builders, or real estate sales agents or brokers. (3) A... other industry partners. The disclosure must clearly state that the client is not obligated to...

  6. Fungal Planet description sheets: 214–280

    Crous, P.W.; Shivas, R.G.; W. Quaedvlieg; Bank, van der, M.; Zhang, Y.(Center for High Energy Physics, Tsinghua University, Beijing, China); Summerell, B.A.; Guarro, J.; Wingfield, M.J.; Wood, A.R.; Alfenas, A.C.; Braun, U.; Cano-Lira, J.F.; García, D.; P. Alvarado; Andrade, J.P.

    2014-01-01

    Novel species of microfungi described in the present study include the following from South Africa: Cercosporella dolichandrae from Dolichandra unguiscati, Seiridium podocarpi from Podocarpus latifolius, Pseudocercospora parapseudarthriae from Pseudarthria hookeri, Neodevriesia coryneliae from Corynelia uberata on leaves of Afrocarpus falcatus, Ramichloridium eucleae from Euclea undulata and Stachybotrys aloeticola from Aloe sp. (South Africa), as novel member of the Stachybotriaceae fam. nov...

  7. 6 CFR 21.4 - Definitions.

    2010-01-01

    ... NATIONAL ORIGIN IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM THE DEPARTMENT OF... financial assistance, and application means such an application, request, or plan. (b) Facility includes all... the provision of facilities includes the construction, expansion, renovation, remodeling,...

  8. 49 CFR 214.7 - Definitions.

    2010-10-01

    ... struck by a moving train or on-track equipment, or in any case is within four feet of the field side of... with track centers spaced less than 25 feet apart. Anchorage means a secure point of attachment for..., an interlocking, or a controlled point, or a segment of controlled track. Controlled track...

  9. BDML Metadata: 214 [SSBD[Archive

    Full Text Available NC-SA 0.150 f5a7a976-0215-4b87-8dfd-5a952cc85fe2 0.105 x 0.105 x 0.5 (micrometer), 40 (second) http://ssbd.qbic.riken.jp/data.../source/Ce_KK_P002/RNAi_T20G5.1_040907_01/ http://ssbd.qbic.riken.jp/data.../bdml/Ce_KK_P002/RNAi_T20G5.1_040907_01.bdml0.15.xml http://ssbd.qbic.riken.jp/data/pdpml/Ce_KK_P00...2.pdpml0.05.xml http://ssbd.qbic.riken.jp/search/f5a7a976-0215-4b87-8dfd-5a952cc85fe2/ http://ssbd.qbic.riken.jp/omero/webclient/?show=dataset-157 ...

  10. 49 CFR 195.214 - Welding procedures.

    2010-10-01

    ... accordance with welding procedures qualified under Section 5 of API 1104 or Section IX of the ASME Boiler and Pressure Vessel Code (incorporated by reference, see § 195.3) . The quality of the test welds used...

  11. Fungal Planet description sheets: 214-280.

    Crous, P W; Shivas, R G; Quaedvlieg, W; van der Bank, M; Zhang, Y; Summerell, B A; Guarro, J; Wingfield, M J; Wood, A R; Alfenas, A C; Braun, U; Cano-Lira, J F; García, D; Marin-Felix, Y; Alvarado, P; Andrade, J P; Armengol, J; Assefa, A; den Breeÿen, A; Camele, I; Cheewangkoon, R; De Souza, J T; Duong, T A; Esteve-Raventós, F; Fournier, J; Frisullo, S; García-Jiménez, J; Gardiennet, A; Gené, J; Hernández-Restrepo, M; Hirooka, Y; Hospenthal, D R; King, A; Lechat, C; Lombard, L; Mang, S M; Marbach, P A S; Marincowitz, S; Marin-Felix, Y; Montaño-Mata, N J; Moreno, G; Perez, C A; Pérez Sierra, A M; Robertson, J L; Roux, J; Rubio, E; Schumacher, R K; Stchigel, A M; Sutton, D A; Tan, Y P; Thompson, E H; van der Linde, E; Walker, A K; Walker, D M; Wickes, B L; Wong, P T W; Groenewald, J Z

    2014-06-01

    Novel species of microfungi described in the present study include the following from South Africa: Cercosporella dolichandrae from Dolichandra unguiscati, Seiridium podocarpi from Podocarpus latifolius, Pseudocercospora parapseudarthriae from Pseudarthria hookeri, Neodevriesia coryneliae from Corynelia uberata on leaves of Afrocarpus falcatus, Ramichloridium eucleae from Euclea undulata and Stachybotrys aloeticola from Aloe sp. (South Africa), as novel member of the Stachybotriaceae fam. nov. Several species were also described from Zambia, and these include Chaetomella zambiensis on unknown Fabaceae, Schizoparme pseudogranati from Terminalia stuhlmannii, Diaporthe isoberliniae from Isoberlinia angolensis, Peyronellaea combreti from Combretum mossambiciensis, Zasmidium rothmanniae and Phaeococcomyces rothmanniae from Rothmannia engleriana, Diaporthe vangueriae from Vangueria infausta and Diaporthe parapterocarpi from Pterocarpus brenanii. Novel species from the Netherlands include: Stagonospora trichophoricola, Keissleriella trichophoricola and Dinemasporium trichophoricola from Trichophorum cespitosum, Phaeosphaeria poae, Keissleriella poagena, Phaeosphaeria poagena, Parastagonospora poagena and Pyrenochaetopsis poae from Poa sp., Septoriella oudemansii from Phragmites australis and Dendryphion europaeum from Hedera helix (Germany) and Heracleum sphondylium (the Netherlands). Novel species from Australia include: Anungitea eucalyptorum from Eucalyptus leaf litter, Beltraniopsis neolitseae and Acrodontium neolitseae from Neolitsea australiensis, Beltraniella endiandrae from Endiandra introrsa, Phaeophleospora parsoniae from Parsonia straminea, Penicillifer martinii from Cynodon dactylon, Ochroconis macrozamiae from Macrozamia leaf litter, Triposporium cycadicola, Circinotrichum cycadis, Cladosporium cycadicola and Acrocalymma cycadis from Cycas spp. Furthermore, Vermiculariopsiella dichapetali is described from Dichapetalum rhodesicum (Botswana), Ophiognomonia acadiensis from Picea rubens (Canada), Setophoma vernoniae from Vernonia polyanthes and Penicillium restingae from soil (Brazil), Pseudolachnella guaviyunis from Myrcianthes pungens (Uruguay) and Pseudocercospora neriicola from Nerium oleander (Italy). Novelties from Spain include: Dendryphiella eucalyptorum from Eucalyptus globulus, Conioscypha minutispora from dead wood, Diplogelasinospora moalensis and Pseudoneurospora canariensis from soil and Inocybe lanatopurpurea from reforested woodland of Pinus spp. Novelties from France include: Kellermania triseptata from Agave angustifolia, Zetiasplozna acaciae from Acacia melanoxylon, Pyrenochaeta pinicola from Pinus sp. and Pseudonectria rusci from Ruscus aculeatus. New species from China include: Dematiocladium celtidicola from Celtis bungeana, Beltrania pseudorhombica, Chaetopsina beijingensis and Toxicocladosporium pini from Pinus spp. and Setophaeosphaeria badalingensis from Hemerocallis fulva. Novel genera of Ascomycetes include Alfaria from Cyperus esculentus (Spain), Rinaldiella from a contaminated human lesion (Georgia), Hyalocladosporiella from Tectona grandis (Brazil), Pseudoacremonium from Saccharum spontaneum and Melnikomyces from leaf litter (Vietnam), Annellosympodiella from Juniperus procera (Ethiopia), Neoceratosperma from Eucalyptus leaves (Thailand), Ramopenidiella from Cycas calcicola (Australia), Cephalotrichiella from air in the Netherlands, Neocamarosporium from Mesembryanthemum sp. and Acervuloseptoria from Ziziphus mucronata (South Africa) and Setophaeosphaeria from Hemerocallis fulva (China). Several novel combinations are also introduced, namely for Phaeosphaeria setosa as Setophaeosphaeria setosa, Phoma heteroderae as Peyronellaea heteroderae and Phyllosticta maydis as Peyronellaea maydis. Morphological and culture characteristics along with ITS DNA barcodes are provided for all taxa. PMID:25264390

  12. Fungal Planet description sheets: 214–280

    Crous, P.W.; Shivas, R.G.; Quaedvlieg, W.; Bank, van der M.; Zhang, Y.; Summerell, B.A.; Guarro, J.; Wingfield, M.J.; Wood, A.R.; Alfenas, A.C.; Braun, U.; Cano-Lira, J.F.; Garcia, D.; Marin-Felix, Y.; Alvarado, P.; Andrade, J.P.; Armengol, J.; Assefa, A.; Breeÿen, den A.; Camele, I.; Cheewangkoon, R.; Souza, De J.T.; Duong, T.A.; Esteve-Raventós, F.; Fournier, J.; Frisullo, S.; García-Jiménez, J.; Gardiennet, A.; Gené, J.; Hernández-Restrepo, M.; Hirooka, Y.; Hospenthal, D.R.; King, A.; Lechat, C.; Lombard, L.; Mang, S.M.; Marbach, P.A.S.; Marincowitz, S.; Montaño-Mata, N.J.; Moreno, G.; Perez, C.A.; Pérez Sierra, A.M.; Robertson, J.L.; Roux, J.; Rubio, E.; Schumacher, R.K.; Stchigel, A.M.; Sutton, D.A.; Tan, Y.P.; Thompson, E.H.; Vanderlinde, E.; Walker, A.K.; Walker, D.M.; Wickes, B.L.; Wong, P.T.W.; Groenewald, J.Z.

    2014-01-01

    Novel species of microfungi described in the present study include the following from South Africa: Cercosporella dolichandrae from Dolichandra unguiscati, Seiridium podocarpi from Podocarpus latifolius, Pseudocercospora parapseudarthriae from Pseudarthria hookeri, Neodevriesia coryneliae from Coryn

  13. QTL Information Table: 214 [Q-TARO

    Full Text Available n of an Elite Rice Hybrid Revealed That Heterozygotes Are Not Always Advantageous for Performance. Genetics 162, 1885-1895. http://www.genetics.org/cgi/content/abstract/162/4/1885 ...

  14. 24 CFR 884.214 - Marketing.

    2010-04-01

    ... responsible for determination of eligibility of applicants in accordance with the procedure of 24 CFR part... Federal selection preferences in accordance with 24 CFR part 5), and computation of the amount of housing... of any informal hearing, and a statement of final disposition. (7) See 24 CFR part 5 for the...

  15. 24 CFR 214.3 - Definitions.

    2010-04-01

    ... persons with disabilities, avoiding foreclosure, or resolving a financial crisis. Except for reverse.... Counseling. Counselor to client assistance that addresses unique financial circumstances or housing...

  16. 7 CFR 1430.214 - Violations.

    2010-01-01

    ..., shall refund all MILC funds disbursed under of this part. The remedies provided in this subpart shall be... benefits; (3) Failure to comply with highly erodible land conservation and wetland provisions of this 7 CFR... MILC by mutual agreement upon request of the participant if DAFP determines that termination is in...

  17. The Technological Enhancement of Normally Occurring Radioactive Materials in Red Mud due to the Production of Alumina

    Maurice O. Miller

    2016-01-01

    Full Text Available This study investigates the level of technological enhancement of normally occurring radioactive materials (TENORM in the red mud waste due to the production of alumina in Jamaica. Technological enhancements factors (TEF were determined for the uranium, thorium, actinium series, their progenies, and the nonseries potassium-40 using gamma spectrometry. The study concluded that bauxite production technologically enhances the uranium progenies Th-234, Pb-214, Bi-214, and Pa-234 and the thorium-232 progenies Ac-228, Pb-212, and Bi-212 in red mud. The actinium series was technologically enhanced, but K-40 and the thorium daughter, Tl-208, were reduced. The spectrometric comparison of Tl-208 (at 510 keV was unexpected since its other photopeaks at 583 keV, 934 keV, and 968 keV were markedly different. An explanation for this anomaly is discussed. An explanation regarding the process of accumulation and fractionation of organically derived phosphate deposits and potassium-feldspar is offered to explain the spectrometric differences between the alumina product and its waste material, red mud.

  18. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  19. Distribution of trace elements in land plants and botanical taxonomy with special reference to rare earth elements and actinium

    Distribution profiles of trace elements in land plants were studied by neutron activation analysis and radioactivity measurements without activation. Number of botanical samples analyzed were more than three thousand in which more than three hundred botanical species were included. New accumulator plants of Co, Cr, Zn, Cd, rare earth elements, Ac, U, etc., were found. Capabilities of accumulating trace elements can be related to the botanical taxonomy. Discussions are given from view points of inorganic chemistry as well as from botanical physiology

  20. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  1. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the success of {sup 225}Ac radioimmunotherapy.

  2. An aerial radiological survey of the Sandia National Laboratories and surrounding area

    A team from the Remote Sensing Laboratory conducted an aerial radiological survey of the area surrounding the Sandia National Laboratories and Kirtland Air Force Base in Albuquerque, New Mexico, during March and April 1993. The survey team measured the terrestrial gamma radiation at the site to determine the levels of natural and man-made radiation. This survey includes the areas covered by a previous survey in 1981. The results of the aerial survey show a background exposure rate which varies between 5 and 18 μR/h plus an approximate 6 μR/h contribution from cosmic rays. The major radioactive isotopes found in this survey were: potassium-40, thallium-208, bismuth-214, and actinium-228, which are all naturally-occurring isotopes, and cobalt-60, cesium-137, and excess amounts of thallium-208 and actinium-228, which are due to human actions in the survey area. In regions away from man-made activity, the exposure rates inferred from this survey's gamma ray measurements agree almost exactly with the exposure rates inferred from the 1981 survey. In addition to the aerial measurements, another survey team conducted in situ and soil sample radiation measurements at three sites within the survey perimeter. These ground-based measurements agree with the aerial measurements within ± 5%

  3. Parenting and Career Development. ERIC Digest No. 214.

    Kerka, Sandra

    Research indicates that parenting styles, family functioning, and parent-child interaction influence career development. The authoritative parenting style is associated with self-confidence, persistence, social competence, academic success, and psychosocial development; parents provide a warm family climate, set standards, and promote independence…

  4. 13 CFR 400.214 - Participations in guaranteed loans.

    2010-01-01

    ...) Subject to paragraphs (b), (c) and (d) of this section, a Lender may distribute the risk of a portion of a... commencing or solidifying the supplier or customer relationship with the borrower; or (4) Any other...

  5. 48 CFR 33.214 - Alternative dispute resolution (ADR).

    2010-10-01

    ... agency guidelines. Such guidelines shall provide advice on the appropriate use of binding arbitration and... not require arbitration as a condition of award, unless arbitration is otherwise required by law... controversy as they arise. (2) An agreement to use arbitration shall be in writing and shall specify a...

  6. Dicty_cDB: CHJ214 [Dicty_cDB

    Full Text Available 1.1 AL590447_45( AL590447 |pid:none) chromosome VII of strain GB-M1 of... 35 2.4 FM992688_582( FM992688 |pid:none) Candida dubli...niensis CD36 chromo... 35 3.1 FM992690_440( FM992690 |pid:none) Candida dubliniensis CD3

  7. 9 CFR 113.214 - Parvovirus Vaccine, Killed Virus (Canine).

    2010-01-01

    ... Seed. (a) The Master Seed shall meet the applicable general requirements prescribed in § 113.200. (b... antibody against canine parvovirus to determine susceptibility. A constant virus-varying serum... vaccination, a second serum sample shall be drawn from each dog and tested for neutralizing antibody to...

  8. Dicty_cDB: SFL214 [Dicty_cDB

    Full Text Available lqvvkcldhinq*syiy* ifqrwlth*rv*lwnykiapthyynqlllqpifkqhsfilmspf*LVLSHVVQVCKEKDL L...cldhinq*syiy* ifqrwlth*rv*lwnykiapthyynqlllqpifkqhsfilmspf*LVLSHVVQVCKEKDL LKVNVSIFKEQGEALNKYASRGVKVLVVGNPAN

  9. 38 CFR 21.214 - Furnishing supplies for special programs.

    2010-07-01

    ... AFFAIRS (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Vocational Rehabilitation and Employment Under... veteran pursuing one of the following types of vocational rehabilitation programs is eligible for any... assistance for: (1) Purchase of, or part payment for, land and buildings; (2) Making full or part payment...

  10. 48 CFR 833.214 - Alternative dispute resolution (ADR).

    2010-10-01

    ... Alternative dispute resolution (ADR). Contracting officers and contractors are encouraged to use alternative dispute resolution (ADR) procedures. CBCA guidance on ADR may be obtained at http://www.cbca.gsa.gov. ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Alternative...