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Sample records for actinium 211

  1. Extraction of actinium with di-(2-ethylhexyl)phosphoric acid from hydrochloric and nitric acid solutions

    The extraction of actinium with HDEHP from Cl- and NO3- systems has been investigated. It was found that extraction of actinium from HCl solutions is much better than from HNO3 solutions. Stability constants of actinium complexes Ac(X-)+2 with Cl- and NO3- ligands were determined. Our results show that the actinium formed less stable complexes with Cl- than with NO3- ligands. 5 refs., 3 figs., 1 tab. (author)

  2. The sorption of polonium, actinium and protactinium onto geological materials

    This paper describes a combined experimental and modeling program of generic sorption studies to increase confidence in the performance assessment for a potential high-level radioactive waste repository in Japan. The sorption of polonium, actinium and protactinium onto geological materials has been investigated. Sorption of these radioelements onto bentonite, tuff and granodiorite from equilibrated de-ionized water was studied under reducing conditions at room temperature. In addition, the sorption of actinium and protactinium was investigated at 60 C. Thermodynamic chemical modeling was carried out to aid interpretation of the results

  3. Separation of Actinium 227 from the uranium minerals

    The purpose of this work was to separate Actinium 227, whose content is 18%, from the mineral carnotite found in Gomez Chihuahua mountain range in Mexico. The mineral before processing is is pre-concentrated and passed, first through anionic exchange resins, later the eluate obtained is passed through cationic resins. The resins were 20-50 MESH QOWEX and 100-200 MESH 50 X 8-20 in some cased 200-400 MESH AG 50W-X8, 1X8 in other cases. The eluates from the ionic exchange were electrodeposited on stainless steel polished disc cathode and platinum electrode as anode; under a current ODF 10mA for 2.5 to 5 hours and of 100mA for .5 of an hour. it was possible to identify the Actinium 227 by means of its descendents, TH-227 and RA-223, through alpha spectroscopy. Due to the radiochemical purity which the electro deposits were obtained the Actinium 227 was low and was not quantitatively determined. A large majority of the members of the natural radioactive series 3 were identified and even alpha energies reported in the literature with very low percentages of non-identified emissions were observed. We conclude that a more precise study is needed concerning ionic exchange and electrodeposit to obtain an Actinium 227 of radiochemical purity. (Author)

  4. Spectroscopic and computational investigation of actinium coordination chemistry.

    Ferrier, Maryline G; Batista, Enrique R; Berg, John M; Birnbaum, Eva R; Cross, Justin N; Engle, Jonathan W; La Pierre, Henry S; Kozimor, Stosh A; Lezama Pacheco, Juan S; Stein, Benjamin W; Stieber, S Chantal E; Wilson, Justin J

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, Ac(III) reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between Ac(III) and Am(III) in HCl solutions indicate Ac(III) coordinates more inner-sphere Cl(1-) ligands (3.2±1.1) than Am(III) (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique Ac(III) chemical behaviour. PMID:27531582

  5. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    Fry, C; Thoennessen, M

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  6. Production of high-purity radium-223 from legacy actinium-beryllium neutron sources.

    Soderquist, Chuck Z; McNamara, Bruce K; Fisher, Darrell R

    2012-07-01

    Radium-223 is a short-lived alpha-particle-emitting radionuclide with potential applications in cancer treatment. Research to develop new radiopharmaceuticals employing (223)Ra has been hindered by poor availability due to the small quantities of parent actinium-227 available world-wide. The purpose of this study was to develop innovative and cost-effective methods to obtain high-purity (223)Ra from (227)Ac. We obtained (227)Ac from two surplus actinium-beryllium neutron generators. We retrieved the actinium/beryllium buttons from the sources and dissolved them in a sulfuric-nitric acid solution. A crude actinium solid was recovered from the solution by coprecipitation with thorium fluoride, leaving beryllium in solution. The crude actinium was purified to provide about 40 milligrams of actinium nitrate using anion exchange in methanol-water-nitric acid solution. The purified actinium was then used to generate high-purity (223)Ra. We extracted (223)Ra using anion exchange in a methanol-water-nitric acid solution. After the radium was separated, actinium and thorium were then eluted from the column and dried for interim storage. This single-pass separation produces high purity, carrier-free (223)Ra product, and does not disturb the (227)Ac/(227)Th equilibrium. A high purity, carrier-free (227)Th was also obtained from the actinium using a similar anion exchange in nitric acid. These methods enable efficient production of (223)Ra for research and new alpha-emitter radiopharmaceutical development. PMID:22697483

  7. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  8. Radium, thorium, and actinium extraction from seawater using an improved manganese-oxide-coated fiber

    Laboratory experiments were conducted to determine the efficiency with which improved manganese-oxide-coated acrylic fibers extract radium, thorium, and actinium from seawater. Tests were made using surface seawater spiked with 227Ac, 227Th and 223Ra. For sample volumes of approximately 30 liters and flow rates up to 0.5 liters per minute, radium and actinium are removed quantitatively. Approximately 80-95% of the thorium is removed under these same conditions. (Auth.)

  9. CJS 211 COURSE TUTORIAL/ snaptutorial

    viswanadh

    2015-01-01

    For more classes visit www.snaptutorial.com CJS 211 Week 1 Individual Assignment Ethical Dilemma Paper CJS 211 Week 1 DQ 1 CJS 211 Week 1 DQ 2 CJS 211 Week 2 Individual Assignment Ethical Dilemma Worksheet Law Enforcement CJS 211 Week 2 DQ 1 CJS 211 Week 2 DQ 2 CJS 211 Week 2 Team Assignment Ethical Decision Making Paper CJS 211 Week 3 Individual Assignment Ethical Dilemma Worksheet Prosecutors CJS 211 Week 3 Team Assignment Ethics Issue Presentation ...

  10. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces ∼100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 GeV protons

  11. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  12. Neutron-Induced Fission of Actinium-227, Protactinium-231 and Neptunium-237: Mass Distribution

    Results of radiochemical studies on the mass distribution in the neutron-induced fission of actinium-227, protactinium-231 and neptunium-237 have been presented. This work has been carried out as part of a programme to determine the mass distribution in the fission of heavy elements as a function of Z and A. All irradiations have been carried out in the core of the swimming-pool type reactor APSARA with cadmium shielding wherever necessary. Relative yields of several fission product nuclides have been obtained by a method involving a comparison of the fission product activities from the respective targets with those formed from uranium-235 simultaneously irradiated. Thermal-neutron fission yields of uranium-235 have been assumed. These results indicate a predominantly asymmetric mass distribution in all the three cases, and also a distinct though small symmetric peak in the case of actinium-227. (author)

  13. A new method for the determination of low-level actinium-227 in geological samples

    We developed a new method for the determination of 227Ac in geological samples. The method uses extraction chromatographic techniques and alpha-spectrometry and is applicable for a range of natural matrices. Here we report on the procedure and results of the analysis of water (fresh and seawater) and rock samples. Water samples were acidified and rock samples underwent total dissolution via acid leaching. A DGA (N,N,N',N'-tetra-n-octyldiglycolamide) extraction chromatographic column was used for the separation of actinium. The actinium fraction was prepared for alpha spectrometric measurement via cerium fluoride micro-precipitation. Recoveries of actinium in water samples were 80 ± 8 % (number of analyses n = 14) and in rock samples 70 ± 12 % (n = 30). The minimum detectable activities (MDA) were 0.017-0.5 Bq kg-1 for both matrices. Rock sample 227Ac activities ranged from 0.17 to 8.3 Bq kg-1 and water sample activities ranged from below MDA values to 14 Bq kg-1of 227Ac. From the analysis of several standard rock and water samples with the method we found very good agreement between our results and certified values. (author)

  14. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    Momeni, M.H.

    1981-09-01

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore.

  15. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore

  16. CJS 211 Course Tutorial/TutorialRank

    candice

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 8 Times, Rating: A+   CJS 211 Week 1 Individual Assignment Ethical Dilemma Paper CJS 211 Week 1 DQ 1 CJS 211 Week 1 DQ 2 CJS 211 Week 2 Individual Assignment Ethical Dilemma Worksheet Law Enforcement CJS 211 Week 2 DQ 1 CJS 211 Week 2 DQ 2 CJS 211 Week 2 Team Assignment Ethical Decision Making Paper CJS 211 Week 3 Individual Assignment Ethical Dilemma Worksheet Prosecutors...

  17. In-source laser spectroscopy developments at TRILIS—towards spectroscopy on actinium and scandium

    Resonance Ionization Laser Ion Sources (RILIS) have become a versatile tool for production and study of exotic nuclides at Isotope Separator On-Line (ISOL) facilities such as ISAC at TRIUMF. The recent development and addition of a grating tuned spectroscopy laser to the TRIUMF RILIS solid state laser system allows for wide range spectral scans to investigate atomic structures on short lived isotopes, e.g., those from the element actinium, produced in uranium targets at ISAC. In addition, development of new and improved laser ionization schemes for rare isotope production at ISAC is ongoing. Here spectroscopic studies on bound states, Rydberg states and autoionizing (AI) resonances on scandium using the existing off-line capabilities are reported. These results allowed to identify a suitable ionization scheme for scandium via excitation into an autoionizing state at 58,104 cm − 1 which has subsequently been used for ionization of on-line produced exotic scandium isotopes.

  18. Astatine-211: production and availability.

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production. PMID:22201707

  19. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Raeder, S.; Bastin, B.; Block, M.; Creemers, P.; Delahaye, P.; Ferrer, R.; Fléchard, X.; Franchoo, S.; Ghys, L.; Gaffney, L. P.; Granados, C.; Heinke, R.; Hijazi, L.; Huyse, M.; Kron, T.; Kudryavtsev, Yu.; Laatiaoui, M.; Lecesne, N.; Luton, F.; Moore, I. D.; Martinez, Y.; Mogilevskiy, E.; Naubereit, P.; Piot, J.; Rothe, S.; Savajols, H.; Sels, S.; Sonnenschein, V.; Traykov, E.; Van Beveren, C.; Van den Bergh, P.; Van Duppen, P.; Wendt, K.; Zadvornaya, A.

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  20. 1 CFR 21.1 - Drafting.

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Drafting. 21.1 Section 21.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS PREPARATION OF DOCUMENTS SUBJECT TO CODIFICATION General § 21.1 Drafting. (a) Each agency that prepares...

  1. 8 CFR 211.5 - Alien commuters.

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Alien commuters. 211.5 Section 211.5 Aliens...: IMMIGRANTS; WAIVERS § 211.5 Alien commuters. (a) General. An alien lawfully admitted for permanent residence.... An alien commuter engaged in seasonal work will be presumed to have taken up residence in the...

  2. 25 CFR 211.20 - Leasing procedures.

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Leasing procedures. 211.20 Section 211.20 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEASING OF TRIBAL LANDS FOR MINERAL DEVELOPMENT How To Acquire Leases § 211.20 Leasing procedures. (a) Indian mineral owners may, with...

  3. 47 CFR 53.211 - Audit planning.

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Audit planning. 53.211 Section 53.211 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) SPECIAL PROVISIONS CONCERNING BELL OPERATING COMPANIES Separate Affiliate; Safeguards § 53.211 Audit planning....

  4. 14 CFR 417.211 - Debris analysis.

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Debris analysis. 417.211 Section 417.211... TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.211 Debris analysis. (a) General. A flight safety analysis must include a debris analysis. For an orbital or suborbital launch, a debris...

  5. 5 CFR 211.101 - Purpose.

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Purpose. 211.101 Section 211.101 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS VETERAN PREFERENCE § 211.101 Purpose. The purpose of this part is to define veterans' preference and the administration of...

  6. 40 CFR 211.110 - Exemptions.

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Exemptions. 211.110 Section 211.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS PRODUCT NOISE LABELING General Provisions § 211.110 Exemptions....

  7. 40 CFR 211.105 - Label format.

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Label format. 211.105 Section 211.105 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS PRODUCT NOISE LABELING General Provisions § 211.105 Label format. (a) Unless specified otherwise in other...

  8. 40 CFR 211.202 - Effective date.

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Effective date. 211.202 Section 211.202 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS PRODUCT NOISE LABELING Hearing Protective Devices § 211.202 Effective date. Manufacturers of...

  9. 40 CFR 211.104 - Label content.

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Label content. 211.104 Section 211.104 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS PRODUCT NOISE... Required by U.S. EPA regulation 40 CFR part 211, subpart ___.” EC01FE92.055...

  10. 40 CFR 211.210 - Requirements.

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirements. 211.210 Section 211.210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS PRODUCT NOISE LABELING Hearing Protective Devices § 211.210 Requirements....

  11. 7 CFR 3565.211 - Interest credit.

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Interest credit. 3565.211 Section 3565.211... AGRICULTURE GUARANTEED RURAL RENTAL HOUSING PROGRAM Loan Requirements § 3565.211 Interest credit. (a... assistance in the form of interest credit, to the extent necessary to reduce the agreed-upon rate of...

  12. 49 CFR 399.211 - Maintenance.

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Maintenance. 399.211 Section 399.211 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY... STANDARDS Step, Handhold, and Deck Requirements for Commercial Motor Vehicles § 399.211 Maintenance....

  13. 12 CFR 211.42 - Definitions.

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Definitions. 211.42 Section 211.42 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM INTERNATIONAL BANKING OPERATIONS (REGULATION K) International Lending Supervision § 211.42 Definitions. For the purposes of...

  14. 33 CFR 117.211 - Mystic River.

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Mystic River. 117.211 Section 117.211 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.211 Mystic River. (a) The draw of the...

  15. 40 CFR 21.1 - Scope.

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Scope. 21.1 Section 21.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL SMALL BUSINESS § 21.1 Scope. This part establishes procedures for the issuance by EPA of the statements, referred to in section 7(g) of the Small Business...

  16. 21 CFR 211.137 - Expiration dating.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Expiration dating. 211.137 Section 211.137 Food... § 211.137 Expiration dating. (a) To assure that a drug product meets applicable standards of identity, strength, quality, and purity at the time of use, it shall bear an expiration date determined...

  17. 49 CFR 211.75 - Evidence.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Evidence. 211.75 Section 211.75 Transportation... TRANSPORTATION RULES OF PRACTICE Interim Procedures for the Review of Emergency Orders § 211.75 Evidence. (a) The Federal Rules of Evidence for United States Courts and Magistrates shall be employed as general...

  18. Dicty_cDB: CHQ211 [Dicty_cDB

    Full Text Available CH (Link to library) CHQ211 (Link to dictyBase) - - - - CHQ211P (Link to Original site) CHQ211F ... TFAYNIPLIKQVGVSSGSSILTVRISVDLGYVEQTQPPTQPPTQPPTQPP TPP --- ---FDNHKTGLHDYTNAFGATKGGRDIIVTTGFDYYEAFEGSIRWYN ... TFAYNIPLIKQVGVSSGSSILTVRISVDLGYVEQTQPPTQPPTQPPTQPP TPP --- ---FDNHKTGLHDYTNAFGATKGGRDIIVTTGFDYYEAFEGSIRWYN ...

  19. 38 CFR 3.211 - Death.

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Death. 3.211 Section 3..., Compensation, and Dependency and Indemnity Compensation Evidence Requirements § 3.211 Death. Death should be... community where death occurred. (2) A copy of a coroner's report of death or a verdict of a coroner's...

  20. 21 CFR 211.173 - Laboratory animals.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Laboratory animals. 211.173 Section 211.173 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS... Laboratory animals. Animals used in testing components, in-process materials, or drug products for...

  1. 21 CFR 211.176 - Penicillin contamination.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Penicillin contamination. 211.176 Section 211.176... Penicillin contamination. If a reasonable possibility exists that a non-penicillin drug product has been exposed to cross-contamination with penicillin, the non-penicillin drug product shall be tested for...

  2. 47 CFR 1.211 - Service.

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Service. 1.211 Section 1.211 Telecommunication... Service. Except as otherwise expressly provided in this chapter, all pleadings filed in a hearing... counsel, then upon such party. All such papers shall be accompanied by proof of service. For...

  3. 14 CFR 91.211 - Supplemental oxygen.

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Supplemental oxygen. 91.211 Section 91.211 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC...) At flight altitudes above flight level 250 unless at least a 10-minute supply of supplemental...

  4. 21 CFR 211.58 - Maintenance.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Maintenance. 211.58 Section 211.58 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL... Maintenance. Any building used in the manufacture, processing, packing, or holding of a drug product shall...

  5. 49 CFR 1542.211 - Identification systems.

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Identification systems. 1542.211 Section 1542.211... systems. (a) Personnel identification system. The personnel identification system under §§ 1542.201(b)(3... identification media stock and supplies. (iv) Auditing the system at a minimum of once a year or sooner,...

  6. 29 CFR 1952.211 - Developmental schedule.

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Developmental schedule. 1952.211 Section 1952.211 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... schedule. (a) Occupational health study accepted and implementation begun July, 1973; (b) Compliance...

  7. 27 CFR 24.211 - Formula required.

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Formula required. 24.211... OF THE TREASURY LIQUORS WINE Production of Other Than Standard Wine § 24.211 Formula required. The proprietor who desires to produce wine other than standard wine shall first obtain approval of the formula...

  8. 21 CFR 211.56 - Sanitation.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Sanitation. 211.56 Section 211.56 Food and Drugs... Sanitation. (a) Any building used in the manufacture, processing, packing, or holding of a drug product shall... assigning responsibility for sanitation and describing in sufficient detail the cleaning schedules,...

  9. 12 CFR 741.211 - Advertising.

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Advertising. 741.211 Section 741.211 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS REQUIREMENTS FOR INSURANCE Regulations Codified Elsewhere in NCUA's Regulations as Applying to Federal Credit Unions...

  10. 12 CFR 211.9 - Investment procedures.

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Investment procedures. 211.9 Section 211.9... the case of an Edge corporation not engaged in banking. (5) Investment in a general partnership or... have no existing banking presence. (f) Prior notice. An investment that does not qualify for...

  11. Astatine-211-Labeled Targeted Radiotherapeutics: An Update

    The heavy halogen 211At was first proposed for use in α-particle targeted radiotherapy more than 30 years ago and continues to be one of the most promising radionuclides for this purpose. Although its 7.2-h half life is not ideal for intravenously administered whole antibodies, it is compatible with the pharmacokinetics of antibody fragments, peptides, aptamers and organic molecules. Its diverse chemistry allows its incorporation into a wide array of targeting vehicles, relying on its chemical similarity to iodine to provide a useful point of departure. On the other hand, the relatively low carbon-astatine bond strength is challenging. In common with the other α-emitters being discussed at this symposium, lack of reliable availability is one of the biggest hurdles in the use of 211At for targeted radiotherapy. However, in the case of 211At, it is not a question of production cost or availability of target material, because 211At can be produced in reasonable yield from natural bismuth targets. Rather, the difficulty is the lack of cyclotrons equipped with the medium energy α-particle beams required for its production. If the infrastructure for producing 211At is to be improved to the stage where 211At-labeled radiopharmaceuticals can have a meaningful impact, several developments must occur. First, the ability to produce clinically relevant levels of 211At that can be shipped to remote locations in chemically tractable form must be demonstrated. Approaches under consideration include compensating for radiolysis-mediated effects and the consideration of alternative chemistries. Second, strategies for compensating for heterogeneities in dose deposition must be developed, hopefully in a way that is compatible with approval for human use. And third, it is essential that more clinical trials be performed with 211At-labeled therapeutics, particularly in settings of minimum residual disease where the radiobiological advantages of α-particles can be best exploited. Our

  12. 48 CFR 252.211-7003 - Item identification and valuation.

    2010-10-01

    ... valuation. 252.211-7003 Section 252.211-7003 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.211-7003 Item identification and valuation. As prescribed in 211.274-6(a), use the following clause: Item Identification and Valuation (AUG 2008) (a) Definitions. As...

  13. 48 CFR 211.272 - Alternate preservation, packaging, and packing.

    2010-10-01

    ..., packaging, and packing. 211.272 Section 211.272 Federal Acquisition Regulations System DEFENSE ACQUISITION... Requirements Documents 211.272 Alternate preservation, packaging, and packing. Use the provision at 252.211-7004, Alternate Preservation, Packaging, and Packing, in solicitations which include...

  14. New method for large scale production of medically applicable Actinium-225 and Radium-223

    Alpha-emitters (211At, 212Bi, 213Bi, 223Ra, 225Ac) are promising for targeted radiotherapy of cancer. Only two alpha decays near a cell membrane result in 50% death of cancer cell and only a single decay inside the cell is required for this. 225Ac may be used either directly or as a mother radionuclide in 213Bi isotope generator. Production of 225Ac is provided by three main suppliers - Institute for Transuranium Elements in Germany, Oak Ridge National Laboratory in USA and Institute of Physics and Power Engineering in Obninsk, Russia. The current worldwide production of 225Ac is approximately 1.7 Ci per year that corresponds to only 100-200 patients that could be treated annually. The common approach for 225Ac production is separation from mother 229Th or irradiation of 226Ra with protons in a cyclotron. Both the methods have some practical limitations to be applied routinely. 225Ac can be also produced by irradiation of natural thorium with medium energy protons . Cumulative cross sections of 225Ac, 227Ac, 227Th, 228Th formations have been obtained recently. Thorium targets (1-9 g) were irradiated by 114-91 MeV proton beam (1-50 μA) at INR linear accelerator. After dissolution in 8 M HNO3 + 0.004 M HF thorium was removed by double LLX by HDEHP in toluene (1:1). Ac and REE were pre-concentrated and separated from Ra and most fission products by DGA-Resin (Triskem). After washing out by 0.01 M HNO3 Ac was separated from REE by TRU Resin (Triskem) in 3 M HNO3 media. About 6 mCi 225Ac were separated in hot cell with chemical yield 85%. The method may be upscaled for production of Ci amounts of the radionuclide. The main impurity is 227Ac (0.1% at the EOB) but it does not hinder 225Ac from being used for medical 225Ac/213Bi generators. (author)

  15. CYFRA 21-1: AN OVERVIEW

    Soma Susan Varghese; Madhavan Nirmal; Sunil, P. M.; Jithin Jose

    2013-01-01

    Cytokeratins are group of intermediate filament proteins and based on thetissue expression, cytokeratins are classified into simple epithelial cytokeratin andstratified epithelial cytokeratins. CK expression pattern in the malignant cells areusually retained from the cell of origin, and therefore CK are being used in tumortyping. Cyfra 21-1 is a soluble fragment of cytokeratin 19 is an acid type cytokeratin,with a molecular weight of 40,000d. The assumption is that Cyfra 21-1 is released into...

  16. Dosimetrical considerations in astatine-211 radioimmunotherapy

    Several dosimetrical quantities have been suggested for use in alpha-particle dosimetry. To evaluate the expected biological effect when using these quantities, a Monte Carlo program was set to register the single-event distribution of both specific energy and alpha-particle track length to a cell nucleus (r=5.6 μm). Distributions were acquired for both 'bound' (simulating the effect of 211At-labelled antibodies bound to antigens on cell surfaces (r=7.0 μm)) as well as 'non-bound' (simulating 211At-labelled antibodies that have not bound to a cell) astatine-211. From these distributions, various theoretical cell survival curves were established for 3 different dosimetrical quantities, i.e. specific energy, number of alpha-particle hits and total track length. The survival curves for all quantities are presented for the corresponding mean absorbed dose in order to facilitate comparisons of the expected effects of using the 3 different quantities for both distributions of 211At decays. The theoretical survival curves presented here could, combined with experiments using 'bound' and 'non-bound' 211At in a single-cell suspension, reveal which dosimetrical quantity is most suitable for 211 At-radioimmunotherapy. (author)

  17. Groundwater seepage from the Ranger uranium mine tailings dam: radioisotopes of radium, thorium and actinium. Supervising Scientist report 106

    Monitoring of bores near the Ranger uranium mine tailings dam has revealed deterioration in water quality in several bores since 1983. In a group of bores to the north of the dam, increases have been observed of up to 500 times for sulphate concentrations and of up to 5 times for 226Ra concentrations. Results are presented here of measurements of members of the uranium, thorium and actinium decay series in borewater samples collected between 1985 and 1993. In particular, measurements of all four naturally-occurring radium isotopes have been used in an investigation of the mechanism of radium concentration changes. For the most seepage-affected bores the major findings of the study include: 228Ra/226Ra 223Ra /226Ra and 224Ra/228Ra ratios all increased over the course of the study; barium concentrations show high seasonal variability, being lower in November than May, but strontium concentrations show a steady increase with time. Calculations show that the groundwater is probably saturated with respect to barite but not with respect to celestite or anglesite; sulphide concentrations are low in comparison with sulphate, and are higher in November than in May; and 227Ac concentrations have increased with time, but do not account for the high 223Ra/226Ra ratios. It is concluded on the basis of these observations that increases in Ra isotope concentrations observed in a number of seepage-affected bores arise from increases in salinity leading to desorption of radium from adsorption sites in the vicinity of the bore rather by direct transport of radium from the tailings. Increased salinity is also causing the observed increases in 227Ac and strontium concentrations, while formation of a barite solid phase in the groundwater is causing the removal of some radium from solution. This is the cause of the increasing radium isotope ratios noted above

  18. CYFRA 21-1: AN OVERVIEW

    Soma Susan Varghese

    2013-07-01

    Full Text Available Cytokeratins are group of intermediate filament proteins and based on thetissue expression, cytokeratins are classified into simple epithelial cytokeratin andstratified epithelial cytokeratins. CK expression pattern in the malignant cells areusually retained from the cell of origin, and therefore CK are being used in tumortyping. Cyfra 21-1 is a soluble fragment of cytokeratin 19 is an acid type cytokeratin,with a molecular weight of 40,000d. The assumption is that Cyfra 21-1 is released intothe bloodstream during cell death, and therefore its level correlates very well with thetumour mass, or more specifically with the necrosis in the tumour, which is a functionof the tumour mass. The aim of this article is to review on cyfra 21-1 and its role as adiagnostic and prognostic marker.

  19. Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator

    In order to utilize a 211At isotope, a promising α-emitter for radionuclide therapy, the chemical properties of astatine isotopes are studied. We have examined wet chemistry methods through the distribution ratios of astatine in liquid-liquid extraction. The astatine isotopes have been found to be well extracted into DIPE and MIBK. We observed that the distribution ratio of astatine isotopes increases with concentrations of HCl greater than 3 M, while it decreases with the HCl concentration less than 2 M. The results will be useful for development of the 211Rn-211At generator. (author)

  20. 22 CFR Appendix I to Part 211 - Operational Plan

    2010-04-01

    ... DISASTER RELIEF, ECONOMIC DEVELOPMENT AND OTHER ASSISTANCE Pt. 211, App. I Appendix I to Part 211...) and (b), will be met. 5. Logistics. Provide a logistics plan that demonstrates the adequacy...

  1. 20 CFR 211.13 - Payments made after death.

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Payments made after death. 211.13 Section 211... CREDITABLE RAILROAD COMPENSATION § 211.13 Payments made after death. Payments made by an employer with respect to a deceased employee but paid after the calendar year of the employee's death to the...

  2. 21 CFR 211.52 - Washing and toilet facilities.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Washing and toilet facilities. 211.52 Section 211.52 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... § 211.52 Washing and toilet facilities. Adequate washing facilities shall be provided, including hot...

  3. 22 CFR 211.6 - Processing, repackaging, and labeling commodities.

    2010-04-01

    ... commodities. 211.6 Section 211.6 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT TRANSFER OF FOOD COMMODITIES FOR FOOD USE IN DISASTER RELIEF, ECONOMIC DEVELOPMENT AND OTHER ASSISTANCE § 211.6 Processing, repackaging, and labeling commodities. (a) Commercial processing and repackaging. Cooperating sponsors...

  4. 5 CFR 179.211 - Notice of salary offset.

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Notice of salary offset. 179.211 Section 179.211 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS Salary Offset § 179.211 Notice of salary offset. (a) Upon receipt of...

  5. 25 CFR 211.56 - Geological and geophysical permits.

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Geological and geophysical permits. 211.56 Section 211.56... FOR MINERAL DEVELOPMENT Rents, Royalties, Cancellations and Appeals § 211.56 Geological and geophysical permits. Permits to conduct geological and geophysical operations on Indian lands which do...

  6. 40 CFR 211.110-3 - Export exemptions.

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Export exemptions. 211.110-3 Section 211.110-3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS PRODUCT NOISE LABELING General Provisions § 211.110-3 Export exemptions. (a) A new...

  7. 40 CFR 211.110-1 - Testing exemption.

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Testing exemption. 211.110-1 Section 211.110-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS PRODUCT NOISE LABELING General Provisions § 211.110-1 Testing exemption. (a) A new...

  8. 34 CFR 300.211 - Information for SEA.

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Information for SEA. 300.211 Section 300.211 Education... DISABILITIES Local Educational Agency Eligibility § 300.211 Information for SEA. The LEA must provide the SEA with information necessary to enable the SEA to carry out its duties under Part B of the Act,...

  9. 21 CFR 211.103 - Calculation of yield.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Calculation of yield. 211.103 Section 211.103 Food... § 211.103 Calculation of yield. Actual yields and percentages of theoretical yield shall be determined... the drug product. Such calculations shall either be performed by one person and independently...

  10. 9 CFR 113.211 - Feline Rhinotracheitis Vaccine, Killed Virus.

    2010-01-01

    ... Virus. 113.211 Section 113.211 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.211 Feline Rhinotracheitis Vaccine, Killed Virus....

  11. 48 CFR 211.274 - Item identification and valuation requirements.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Item identification and valuation requirements. 211.274 Section 211.274 Federal Acquisition Regulations System DEFENSE ACQUISITION... Requirements Documents 211.274 Item identification and valuation requirements....

  12. 48 CFR 211.274-3 - Policy for valuation.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Policy for valuation. 211.274-3 Section 211.274-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Documents 211.274-3 Policy for valuation. (a) It is DoD policy that contractors shall be required...

  13. 36 CFR 211.3 - Cooperation with State officers.

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Cooperation with State officers. 211.3 Section 211.3 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE ADMINISTRATION Cooperation § 211.3 Cooperation with State officers. All forest officers will cooperate with...

  14. 40 CFR 211.103 - Number and gender.

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Number and gender. 211.103 Section 211... PRODUCT NOISE LABELING General Provisions § 211.103 Number and gender. In this part, words in the singular will be understood to include the plural, and words in the masculine gender will be understood...

  15. 34 CFR 21.1 - Equal Access to Justice Act.

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Equal Access to Justice Act. 21.1 Section 21.1 Education Office of the Secretary, Department of Education EQUAL ACCESS TO JUSTICE General § 21.1 Equal Access to Justice Act. (a) The Equal Access to Justice Act (the Act) provides for the award of fees...

  16. 40 CFR 211.212 - Compliance audit testing.

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Compliance audit testing. 211.212 Section 211.212 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS PRODUCT NOISE LABELING Hearing Protective Devices § 211.212 Compliance audit testing....

  17. 4 CFR 21.1 - Filing a protest.

    2010-01-01

    ... a decision on the protest, in accordance with GAO's rules at 4 CFR part 81. If the protester... 4 Accounts 1 2010-01-01 2010-01-01 false Filing a protest. 21.1 Section 21.1 Accounts GOVERNMENT ACCOUNTABILITY OFFICE GENERAL PROCEDURES BID PROTEST REGULATIONS § 21.1 Filing a protest. (a) An interested...

  18. 24 CFR 881.211 - Audit.

    2010-04-01

    ... requirements in 24 CFR part 44 shall apply. (b) Where a nonprofit organization is the eligible owner of a project, receiving financial assistance under this part, the audit requirements in 24 CFR part 45 shall... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Audit. 881.211 Section...

  19. 24 CFR 880.211 - Audit.

    2010-04-01

    ... administrator under § 880.505 receiving financial assistance under this part, the audit requirements in 24 CFR... financial assistance under this part, the audit requirements in 24 CFR part 45 shall apply. ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Audit. 880.211 Section...

  20. 34 CFR 682.211 - Forbearance.

    2010-07-01

    ... citations affecting § 682.211, see the List of CFR Sections Affected, which appears in the Finding Aids.... (a)(1) The Secretary encourages a lender to grant forbearance for the benefit of a borrower or... documentation, as described in § 682.210(n), from a borrower serving in a medical or dental internship...

  1. 42 CFR 2.11 - Definitions.

    2010-10-01

    ... social well-being of the user. Drug abuse means the use of a psychoactive substance for other than... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS General Provisions § 2.11 Definitions. For purposes of these...

  2. 14 CFR 67.211 - Cardiovascular.

    2010-01-01

    ... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN MEDICAL STANDARDS AND CERTIFICATION Second-Class Airman Medical Certificate § 67.211 Cardiovascular. Cardiovascular standards for a second-class medical certificate are no established medical history or clinical diagnosis...

  3. Building 211 cyclotron characterization survey report

    NONE

    1998-03-30

    The Building 211 Cyclotron Characterization Survey includes an assessment of the radioactive and chemical inventory of materials stored within the facility; an evaluation of the relative distribution of accelerator-produced activation products within various cyclotron components and adjacent structures; measurement of the radiation fields throughout the facility; measurement and assessment of internal and external radioactive surface contamination on various equipment, facility structures, and air-handling systems; and an assessment of lead (Pb) paint and asbestos hazards within the facility.

  4. Residual Interactions and High Spin States in A = 211 Isobars

    The shell model has been particularly successful in describing the structure of states near the doubly magic 208Pb core. In particular semi-empirical calculations are able to reproduce the yrast states in the three valence proton nucleus, 211 At to a high degree of accuracy. Recent spectroscopic measurements using a variety of novel reaction mechanisms have provided information on the related A = 211 nuclei 211At, 211Po, 211Bi and 211Pb allowing a comparison between the data and the results of semi-empirical calculations. While good agreement is observed for the lower spin yrast states, the calculations predict the presence of isomeric states not yet completely characterized in the current experiments. (author)

  5. H2 Velocity Structure in HH 211

    Salas, L.; I. Cruz González; Margarita Rosado

    2003-01-01

    Describimos la estructura en velocidad del chorro molecular HH211 en la línea 2.12 Um del H2. Las observaciones fueron obtenidas con un interferómetro Fabry-Pérot con resolución espectral de 24 km s_1. Se pudo observar que el lóbulo este del chorro está corrido al azul mientras que el del oeste está corrido al rojo. La mayor parte de la radiación se origina en bajas velocidades, en concordancia con la relación flujo-velocidad de Salas & Cruz-González (2002), pero estas bajas ...

  6. 17 CFR 256.211 - Miscellaneous paid-in capital.

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Miscellaneous paid-in capital. 256.211 Section 256.211 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... capital. This account shall include the balance of all other credits for paid-in capital which are...

  7. 14 CFR 145.211 - Quality control system.

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Quality control system. 145.211 Section 145...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.211 Quality control system. (a) A certificated repair station must establish and maintain a quality control system acceptable...

  8. 18 CFR 281.211 - Filing and documentation.

    2010-04-01

    ... user which qualifies it as an essential agricultural user in accordance with 7 CFR 2900.3. (C) Includes the data and calculations used to determine essential agricultural requirements under 7 CFR 2900.4. (D... documentation. 281.211 Section 281.211 Conservation of Power and Water Resources FEDERAL ENERGY...

  9. 22 CFR 211.4 - Availability and shipment of commodities.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Availability and shipment of commodities. 211.4 Section 211.4 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT TRANSFER OF FOOD COMMODITIES FOR FOOD... commodities. (a) Shipment, distribution and use of commodities. Commodities shall be available for...

  10. 14 CFR 221.211 - Cancellation of suspended matter.

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Cancellation of suspended matter. 221.211 Section 221.211 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION... matter. When, pursuant to an order of the Department, the cancellation of rules, fares, charges, or...

  11. 21 CFR 211.188 - Batch production and control records.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Batch production and control records. 211.188... Reports § 211.188 Batch production and control records. Batch production and control records shall be prepared for each batch of drug product produced and shall include complete information relating to...

  12. 21 CFR 211.192 - Production record review.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Production record review. 211.192 Section 211.192... Production record review. All drug product production and control records, including those for packaging and... established, approved written procedures before a batch is released or distributed. Any...

  13. 12 CFR 211.11 - Advisory opinions under Regulation K.

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Advisory opinions under Regulation K. 211.11... INTERNATIONAL BANKING OPERATIONS (REGULATION K) International Operations of U.S. Banking Organizations § 211.11 Advisory opinions under Regulation K. (a) Request for advisory opinion. Any person may submit a request...

  14. 40 CFR 211.111 - Testing by the Administrator.

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Testing by the Administrator. 211.111... PROGRAMS PRODUCT NOISE LABELING General Provisions § 211.111 Testing by the Administrator. (a)(1) To determine whether products conform to applicable regulations under this part, the Administrator may...

  15. 49 CFR 211.77 - Appeal to the Administrator.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Appeal to the Administrator. 211.77 Section 211.77... Appeal to the Administrator. (a) Any party aggrieved by the final decision of a presiding officer (other than the Administrator) may appeal to the Administrator. The appeal must be filed within twenty...

  16. 33 CFR 211.22 - Real estate Claims Officers.

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Real estate Claims Officers. 211..., DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Real Estate Claims § 211.22 Real estate Claims Officers. In each Division Office the...

  17. 33 CFR 211.1 - Real estate defined.

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Real estate defined. 211.1... DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Real Estate; General § 211.1 Real estate defined. The term real estate as used in this part includes...

  18. 48 CFR 333.211 - Contracting Officer's decision.

    2010-10-01

    ... decision. (a)(2) The Contracting Officer shall refer a proposed final decision to OGC-GLD, for advice as to the legal sufficiency and format before sending the final decision to the contractor. The Contracting... decision. 333.211 Section 333.211 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES...

  19. 12 CFR 211.13 - Supervision and reporting.

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Supervision and reporting. 211.13 Section 211.13 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM... Supervision and reporting. (a) Supervision—(1) Foreign branches and subsidiaries. U.S. banking...

  20. 50 CFR 660.211 - Fixed gear fishery-definitions.

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Fixed gear fishery-definitions. 660.211... Groundfish-Limited Entry Fixed Gear Fisheries § 660.211 Fixed gear fishery—definitions. These definitions are... weekly and/or bimonthly trip limits. Limited entry fixed gear fishery means the fishery composed...

  1. 37 CFR 211.5 - Deposit of identifying material.

    2010-07-01

    ... material. 211.5 Section 211.5 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS... Program, Library of Congress, Copyright Office - RPO, 101 Independence Avenue, SE, Washington, DC 20559... the Librarian of Congress to order its destruction or other disposition....

  2. 49 CFR 219.211 - Analysis and follow-up.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Analysis and follow-up. 219.211 Section 219.211 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Analysis and follow-up. (a) The laboratory designated in appendix B to this part undertakes prompt...

  3. 5 CFR 211.103 - Administration of preference.

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Administration of preference. 211.103... PREFERENCE § 211.103 Administration of preference. Agencies are responsible for making all preference determinations except for preference based on a common law marriage. Such a claim should be referred to...

  4. 7 CFR 58.211 - Packaging room for bulk products.

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Packaging room for bulk products. 58.211 Section 58... Service 1 Rooms and Compartments § 58.211 Packaging room for bulk products. A separate room or area shall... dust within the packaging room and where needed, a dust collector shall be provided and...

  5. 21 CFR 211.130 - Packaging and labeling operations.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Packaging and labeling operations. 211.130 Section... (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Packaging and Labeling Control § 211.130 Packaging and labeling operations. There shall be written procedures designed...

  6. Development of 211At Chemistry for Labelling Biomolecules

    Our studies have demonstrated that high recovery of 211At can be obtained using a “wet chemistry” approach to isolation from the bismuth target. We have also demonstrated that direct labelling of antibody-B10 conjugates with 211At can be performed in high yields, and that the astatinated antibodies are stable to in vivo deastatination. While these results will allow us to enter clinical studies with 211At-labelled antibodies, the chemistry associated with 211At is not fully understood. Therefore, it is important that many more basic studies to be conducted with 211At, so the optimal labelling reagent for each type of disease-targeting agent becomes apparent

  7. 48 CFR 252.211-7004 - Alternate preservation, packaging, and packing.

    2010-10-01

    ..., packaging, and packing. 252.211-7004 Section 252.211-7004 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.211-7004 Alternate preservation, packaging, and packing. As prescribed in 211.272, use the following provision: Alternate Preservation, Packaging, and Packing (DEC...

  8. Intrahepatic cholangiocarcinoma with increased serum CYFRA 21-1 level.

    Kashihara, T; Ohki, A; Kobayashi, T; Sato, T; Nishizawa, H; Ogawa, K; Tako, H; Kawakami, F; Tsuji, M; Tamaoka, K

    1998-06-01

    CYFRA 21-1 is a fragment of cytokeratin 19 (CK 19). Four patients with large intrahepatic (or peripheral) cholangiocarcinoma (CC) and high serum levels of CYFRA 21-1 (normal, vitamin K absence or antagonist II (PIVKA II) were elevated in all HCC patients (AFP, PIVKA II, respectively; normal range, < or = 10.0 ng/ml and < or = 0.1 AU/ml) CYFRA 21-1 levels were measured twice or three times during the clinical course in 2 CC patients and in 6 HCC patients, and increased gradually with tumor growth in the 2 CC patients and in 3 of the 6 HCC patients. Marked increases in serum CYFRA 21-1 levels in patients with large liver cancers, particularly in those with normal levels of AFP and PIVKA II, would suggest the existence of intrahepatic CC rather than HCC. PMID:9658330

  9. Dicty_cDB: CFI211 [Dicty_cDB

    Full Text Available CF (Link to library) CFI211 (Link to dictyBase) - - - Contig-U15057-1 CFI211P (Link to Original ... *, 1 ordered piece. 38 0.99 7 AF100466 |AF100466.2 Dengue ... virus type 2 strain Mara4 polyprotein gene, comple ... te cds. 46 1.3 1 AF489932 |AF489932.1 Dengue ... Virus Type 2 strain BR64022, complete genome. 46 1 ...

  10. Inactivation of human osteosarcoma cells in vitro by {sup 211}At-TP-3 monoclonal antibody: Comparison with astatine-211 and external-beam X rays

    Larsen, R.H. [Univ. of Oslo (Norway)]|[Institute for Cancer Research, Oslo (Norway); Bruland, O.S. [Institute for Cancer Research, Oslo (Norway); Hoff, P.; Alstad, J. [Univ. of Oslo (Norway); Lindmo, T. [Institute for Cancer Research, Oslo (Norway); Rofstad, E.K. [Norwegian Institute of Technology, Trondheim (Norway)

    1994-08-01

    The potential usefulness of {alpha}-particle radioimmunotherapy in the treatment of osteosarcoma was studied in vitro by using the monoclonal antibody TP-3 and cells of three human osteosarcoma cell lines (OHS, SAOS and KPDX) differing in antigen expression. Cell survival curves were established after treatment with (a) {sup 211}At-TP-3 of different specific activities, (b) {sup 211}At-labeled bovine serum albumin (BSA), (c) free {sup 211}At and (d) external-beam X rays. The three osteosarcoma cell lines showed similar survival curves, whether treated with external-beam X rays, {sup 211}At-BSA or free {sup 211}At. The D{sub o}`s were lower for free {sup 211}At than for {sup 211}At-BSA. The survival curves for {sup 211}At-TP-3 treatment, on the other hand, differed significantly among the cell lines, suggesting that sensitivity to {sup 211}At-TP-3 treatment was governed by cellular properties other than sensitivity to external-beam X rays. The cellular property most important for sensitivity to {sup 211}At-TP-3 treatment was the antigen expression. Cell inactivation after {sup 211}At-TP-3 treatment increased substantially with increasing specific activity of the {sup 211}At-TP-3. At high specific activities, the cytotoxic effect of {sup 211}At-TP-3 was significantly higher than that of {sup 211}At-BSA. In conclusion, {sup 211}At-TP-3 has the potential to give clinically favorable therapeutic ratios in the treatment of osteosarcoma. 39 refs., 5 figs., 2 tabs.

  11. Process for producing astatine-211 for radiopharmaceutical use

    A one-step chemical manipulation is described in combination with a distillation and collection process for producing At-211 comprising; a. providing a target of irradiated Bismuth coated to a predetermined thickness of a backing member, b. providing a vapor-producing still operably connected with a condenser that has a water cooled condensate collector formed of a dry silica gel mesh maintained at a temperature above the freezing point of water, and providing an effluent gas filter that is operably connected to receive effluent gas from the condenser, c. heating the target in the still at a temperature in the range of about 6300-6800C for a time period in the range of 50 to 80 minutes, to evole At-211 vapor from the target, c. providing a dry carrier gas having an oxygen concentration that is sufficient to form Bi/sub 2/O/sub 3/ thereby to essentially preclude vaporization of Bi metal, passing the carrier gas through the still to carry the At-211 vapor to the condenser, and to carry effluent from the condenser to the effluent gas filter, e. eluting At-211 from the condensate collector of the condenser with a controlled volume of eluent containing predetermined solvents that are compatible with a given desired radiopharmaceutical procedure, and f. collecting the At-211 in the controlled volume of eluent for use in the given radiopharmaceutical procedure

  12. Dicty_cDB: AHA211 [Dicty_cDB

    Full Text Available AH (Link to library) AHA211 (Link to dictyBase) - - - Contig-U16427-1 AHA211P (Link to Original ... yfg*ytlyiyiiq*nviffrtdfrkdgfhr*ry*ihgns*sck*irkryf*ngs ... nl*k*ncykiisids*fsk*csrecc*mfrfin*ks*rftsnrny*yiik ... fnfi Homology vs CSM-cDNA Score E Sequences producing s ignificant alignments: (bits) Value VHQ485 (VHQ485 ... 004. 4.27 Homology vs DNA Score E Sequences producing s ignificant alignments: (bits) Value N AC116956 |AC ... 2.22 Homology vs Protein Score E Sequences producing s ignificant alignments: (bits) Value (Q86KD1) RecNa ...

  13. 211 Po alpha decay level scheme

    deformations, so that their shapes in the ground state are represented by spheres. It is very interesting to note, that in the frame of this model, the linked level with 1s1/2 of the alpha particle is predicted to emerge from the orbital 1g9/2 of the spherical 211 Po parent, this level being deeply located in the potential well. Also, it is known that the ground state of the parent is 9/2+ emerging from 2g9/2 and the alpha decay exhibits a fine structure with 98.9% transitions to the ground state of the daughter with spin 1/2- (level 3p1/2), 0.55% transitions to the first single-particle excited state 5/2- (level 2f5/2) and 0.54% transitions to the second single-particle excited state 3/2- (level 3p3/2). In the frame of our formalism the fine structure can be understood by considering transitions between levels with the same quantum numbers in the avoided crossing regions, that means using the Landau-Zener effect. The system having only an axial symmetry, the good quantum number is the projection Ω of the nucleon spin. (author)

  14. 37 CFR 211.6 - Methods of affixation and placement of mask work notice.

    2010-07-01

    ... placement of mask work notice. 211.6 Section 211.6 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT OFFICE AND PROCEDURES MASK WORK PROTECTION § 211.6 Methods of affixation and placement of mask work notice. (a) General. (1) This section specifies methods of affixation and...

  15. Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

    Shigeki Watanabe

    2013-09-01

    Full Text Available A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1 dissolution of bismuth target in conc. HNO3; (2 removal of the HNO3 by distillation; (3 dissolution of residue in 8 M HCl; (4 extraction of 211At from 8 M HCl into DIPE; and (5 extraction of 211At from DIPE into NaOH. Results from 55 “optimized” 211At isolation runs gave recovery yields of approximately 78% after decay and attenuation corrections. An attenuation-corrected average of 26 ± 3 mCi in the target provided isolated (actual yields of 16 ± 3 mCi of 211At. A sixth step, used for purification of 211At from trace metals, was evaluated in seven runs. In those runs, isolated 211At was distilled under reductive conditions to provide an average 71 ± 8% recovery. RadioHPLC analyses of the isolated 211At solutions, both initial and after distillation, were obtained to examine the 211At species present. The primary species of 211At present was astatide, but astatate and unidentified species were also observed. Studies to determine the effect of bismuth attenuation on 211At were conducted to estimate an attenuation factor (~1.33 for adjustment of 211At readings in the bismuth target.

  16. 14 CFR 302.211 - Procedures in certificate cases involving initial or continuing fitness.

    2010-01-01

    ... initial or continuing fitness. 302.211 Section 302.211 Aeronautics and Space OFFICE OF THE SECRETARY... Disposition of Applications § 302.211 Procedures in certificate cases involving initial or continuing fitness... applicant's fitness to operate. Where such applications propose the operation of scheduled service...

  17. 48 CFR 552.211-86 - Maximum weight per shipping container.

    2010-10-01

    ... shipping container. 552.211-86 Section 552.211-86 Federal Acquisition Regulations System GENERAL SERVICES....211-86 Maximum weight per shipping container. As prescribed in 511.204(b)(6), insert the following clause: Maximum Weight per Shipping Container (JAN 2010) In no instance shall the weight of a...

  18. 46 CFR 14.211 - Posting of copy of shipping articles.

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Posting of copy of shipping articles. 14.211 Section 14.211 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN SHIPMENT AND DISCHARGE OF MERCHANT MARINERS Shipment of Merchant Mariners § 14.211 Posting of copy of...

  19. 36 CFR 211.4 - Cooperation for fire prevention and control.

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Cooperation for fire prevention and control. 211.4 Section 211.4 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE ADMINISTRATION Cooperation § 211.4 Cooperation for fire prevention and control. The Forest...

  20. 40 CFR Appendix A to Part 211 - Compliance Audit Testing Report

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Compliance Audit Testing Report A... ABATEMENT PROGRAMS PRODUCT NOISE LABELING Pt. 211, App. A Appendix A to Part 211—Compliance Audit Testing... conformance with applicable regulations under 40 CFR Part 211, et seq. All the data reported here are true...

  1. 22 CFR 1203.735-211 - Activities relating to private organizations and politics.

    2010-04-01

    ... engage in any form of political activity in any foreign country. (h) Activities relating to U.S. politics... politics. 1203.735-211 Section 1203.735-211 Foreign Relations UNITED STATES INTERNATIONAL DEVELOPMENT... Employees § 1203.735-211 Activities relating to private organizations and politics. (a) Definition. For...

  2. 48 CFR 1552.211-80 - Data standards for the transmission of laboratory measurement results.

    2010-10-01

    ... transmission of laboratory measurement results. 1552.211-80 Section 1552.211-80 Federal Acquisition Regulations... Texts of Provisions and Clauses 1552.211-80 Data standards for the transmission of laboratory... Transmission of Laboratory Measurement Results (OCT 2000) This contract requires the transmission...

  3. 48 CFR 852.211-72 - Technical industry standards.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Technical industry....211-72 Technical industry standards. As prescribed in 811.103-70, insert the following provision: Technical Industry Standards (JAN 2008) The supplies or equipment required by this invitation for bid...

  4. 48 CFR 752.211-70 - Language and measurement.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Language and measurement....211-70 Language and measurement. The following clause shall be used in all USAID-direct contracts. Language and Measurement (JUN 1992) (a) The English language shall be used in all written...

  5. 48 CFR 1552.211-76 - Legal analysis.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Legal analysis. 1552.211-76... analysis. As prescribed in 1511.011-76, insert this contract clause when it is determined that the contract involves legal analysis. Legal Analysis (APR 1984) The Contractor shall furnish to the Project Officer...

  6. 211Po - Comments on Evaluation of Decay Data

    This evaluation was completed in August 2009. The literature available by December 31st, 2008 was included. Evaluation Procedures: The Limitation of Relative Statistical Weight (LWM) method was applied for averaging numbers throughout this evaluation; this method was implemented by using the computer code LWEIGHT, ver. 4 (designed for Excel, MS Office). The uncertainty assigned to an average value in this evaluation is never lower than the lowest uncertainty of any of the experimental input values. Decay Scheme; 211Po decays 100% by alpha particle emissions, mainly to the ground state of 207Pb. The most recent evaluations of the 211Po nuclear structure and decay data, published in Nuclear Data Sheets, were done by E. Browne (2004) and M.J. Martin (1993). In the present evaluation, the spin, parity and energy of the levels, together with the multipolarities and mixing ratios of the γ-ray transitions, have been adopted from the A=207 ENSDF mass-chain evaluation 1993Ma73.This data evaluation refers only to the decay of the 211Po ground state, and not to the decay of the 211Po metastable state at 1462 keV (with a half-life of 25.2 s)

  7. 12 CFR 211.8 - Investments and activities abroad.

    2010-01-01

    ... Section 211.8 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM... standards of banking or financial prudence, having due regard for diversification of risks, suitable..., it is the Board's policy to allow activities abroad to be organized and operated as best...

  8. 21 CFR 211.182 - Equipment cleaning and use log.

    2010-04-01

    ... shall be part of the batch record. The persons performing and double-checking the cleaning and... Reports § 211.182 Equipment cleaning and use log. A written record of major equipment cleaning... individual equipment logs that show the date, time, product, and lot number of each batch processed....

  9. 40 CFR 86.211-94 - Exhaust gas analytical system.

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Exhaust gas analytical system. 86.211... analytical system. The provisions of § 86.111-94 apply to this subpart, except that the NOX analyzer is optional. The exhaust gas analytical system must contain components necessary to determine...

  10. 33 CFR 211.2 - Authority to acquire real estate.

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Authority to acquire real estate..., DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Real Estate; General § 211.2 Authority to acquire real estate. (a) Congressional...

  11. 48 CFR 452.211-70 - Brand Name or Equal.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Brand Name or Equal. 452... FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 452.211-70 Brand Name or Equal. As prescribed in 411.171, insert the following provision: Brand Name or Equal (NOV...

  12. 48 CFR 52.211-6 - Brand name or equal.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Brand name or equal. 52....211-6 Brand name or equal. As prescribed in 11.107(a), insert the following provision: Brand Name or Equal (AUG 1999) (a) If an item in this solicitation is identified as “brand name or equal,”...

  13. 27 CFR 26.211 - Warehouse receipts covering distilled spirits.

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Warehouse receipts... and Recordkeeping § 26.211 Warehouse receipts covering distilled spirits. The sale of warehouse..., warehouse receipts for distilled spirits stored in warehouses, or elsewhere, must register and keep...

  14. 48 CFR 52.211-18 - Variation in Estimated Quantity.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Variation in Estimated....211-18 Variation in Estimated Quantity. As prescribed in 11.703(c), insert the following clause in... in the estimated quantity of unit-priced items: Variation in Estimated Quantity (APR 1984) If...

  15. 24 CFR 3286. 211 - Expiration and renewal of installation licenses.

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Expiration and renewal of... Licensing in HUD-Administered States § 3286. 211 Expiration and renewal of installation licenses. (a) Expiration. Each installation license issued or renewed under this subpart C will expire 3 years after...

  16. 27 CFR 25.211 - Beer returned to brewery.

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Beer returned to brewery..., DEPARTMENT OF THE TREASURY LIQUORS BEER Beer Returned to Brewery § 25.211 Beer returned to brewery. (a) General. Beer, produced in the United States, on which the brewer has paid or determined the tax may...

  17. 48 CFR 1852.211-70 - Packaging, handling, and transportation.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Packaging, handling, and... and Clauses 1852.211-70 Packaging, handling, and transportation. As prescribed in 1811.404-70, insert the following clause: Packaging, Handling, and Transportation (SEPT 2005) (a) The Contractor...

  18. 48 CFR 552.211-75 - Preservation, Packaging and Packing.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Preservation, Packaging....211-75 Preservation, Packaging and Packing. As prescribed in 511.204(b)(2), insert the following clause: Preservation, Packaging, and Packing (FEB 1996) Unless otherwise specified, all items shall...

  19. 48 CFR 871.211 - Information concerning correspondence courses.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Information concerning... PROGRAMS Vocational Rehabilitation and Employment Service 871.211 Information concerning correspondence courses. Specific questions on correspondence courses as to the content of courses, academic credit,...

  20. 40 CFR 180.211 - Propachlor; tolerances for residues.

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Propachlor; tolerances for residues...) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.211 Propachlor; tolerances for residues. (a) General. Tolerances are established for the...

  1. 22 CFR 211.1 - General purpose and scope; legislation.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false General purpose and scope; legislation. 211.1...; legislation. (a) Legislation. The Agricultural Trade Development and Assistance Act of 1954, as amended (Pub...-624, 104 Stat. 3632-65 (1990). The legislation implemented by the regulation in this part (as of...

  2. Addressing challenges in preparation of 211At-labeled biomolecules for use in targeted alpha therapy

    There are significant challenges in the development of 211At-labeled biomolecules for application to targeted alpha therapy. Challenges that we have addressed include development of: (1) labeling methods to obtain high in vivo 211At-label stability, (2) approaches to consistently obtain high recovery yields of Na[211At]At from irradiated bismuth targets, (3) methods to optimize biomolecule labeling yields, (4) reagents for use of 211At in pretargeting approach to cancer therapy, and (5) 211At-labeled antibodies in conditioning for hematopoietic cell transplantation. (author)

  3. Discovery of superthermal hydroxyl (OH) in the HH211 outflow

    Tappe, A; Black, J H; Muench, A A

    2008-01-01

    We present a 5-37 micron infrared spectrum obtained with the Spitzer Space Telescope toward the southeastern lobe of the young protostellar outflow HH211. The spectrum shows an extraordinary sequence of OH emission lines arising in highly excited rotational levels up to an energy E/k~28200K above the ground level. This is, to our knowledge, by far the highest rotational excitation of OH observed outside Earth. The spectrum also contains several pure rotational transitions of H2O (v=0), H2 (v=0) S(0) to S(7), HD (v=0) R(3) to R(6), and atomic fine-structure lines of [Fe II], [Si II], [Ne II], [S I], and [Cl I]. The origin of the highly excited OH emission is most likely the photodissociation of H2O by the UV radiation generated in the terminal outflow shock of HH211.

  4. Micromachined cutting blade formed from {211}-oriented silicon

    Fleming, James G.; Sniegowski, Jeffry J.; Montague, Stephen

    2003-09-09

    A cutting blade is disclosed fabricated of micromachined silicon. The cutting blade utilizes a monocrystalline silicon substrate having a {211} crystalline orientation to form one or more cutting edges that are defined by the intersection of {211} crystalline planes of silicon with {111} crystalline planes of silicon. This results in a cutting blade which has a shallow cutting-edge angle .theta. of 19.5.degree.. The micromachined cutting blade can be formed using an anisotropic wet etching process which substantially terminates etching upon reaching the {111} crystalline planes of silicon. This allows multiple blades to be batch fabricated on a common substrate and separated for packaging and use. The micromachined cutting blade, which can be mounted to a handle in tension and optionally coated for increased wear resistance and biocompatibility, has multiple applications including eye surgery (LASIK procedure).

  5. Micromachined cutting blade formed from {211}-oriented silicon

    Fleming, James G. (Albuquerque, NM); Fleming, legal representative, Carol (Burbank, CA); Sniegowski, Jeffry J. (Tijeras, NM); Montague, Stephen (Albuquerque, NM)

    2011-08-09

    A cutting blade is disclosed fabricated of micromachined silicon. The cutting blade utilizes a monocrystalline silicon substrate having a {211} crystalline orientation to form one or more cutting edges that are defined by the intersection of {211} crystalline planes of silicon with {111} crystalline planes of silicon. This results in a cutting blade which has a shallow cutting-edge angle .theta. of 19.5.degree.. The micromachined cutting blade can be formed using an anisotropic wet etching process which substantially terminates etching upon reaching the {111} crystalline planes of silicon. This allows multiple blades to be batch fabricated on a common substrate and separated for packaging and use. The micromachined cutting blade, which can be mounted to a handle in tension and optionally coated for increased wear resistance and biocompatibility, has multiple applications including eye surgery (LASIK procedure).

  6. High spin states and Yrast isomers in 211Rn

    Excited states in 211Rn with spins up to 53/2 have been identified using (HI,xn) reactions and γ-ray techniques. A shell model calculation can reproduce the ordering of the yrast sequence up to spin 41/2-. Several yrast isomers have been identified. Enhanced E3 transitions are observed and their systematic occurrence in this region discussed. The influence of the neutron hole, and possible core excitations on the effective moment of inertia are also pointed out

  7. 75 FR 33738 - Airworthiness Directives; Rolls-Royce plc (RR) RB211-524 Series and RB211 Trent 500, 700, and 800...

    2010-06-15

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78... 12866; 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034... plc (RR) RB211-524 Series and RB211 Trent 500, 700, and 800 Series Turbofan Engines AGENCY:...

  8. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  9. Comparison of (211)At-PRIT and (211)At-RIT of Ovarian Microtumors in a Nude Mouse Model

    Frost, Sofia H L; Bäck, Tom; Chouin, Nicolas;

    2013-01-01

    Abstract Purpose: Pretargeted radioimmunotherapy (PRIT) against intraperitoneal (i.p.) ovarian microtumors using avidin-conjugated monoclonal antibody MX35 (avidin-MX35) and (211)At-labeled, biotinylated, succinylated poly-l-lysine ((211)At-B-PL(suc)) was compared with conventional radioimmunothe....... Despite advanced disease in many animals at the time of treatment, PRIT demonstrated good potential to treat disseminated ovarian cancer....... radioimmunotherapy (RIT) using (211)At-labeled MX35 in a nude mouse model. Methods: Mice were inoculated i.p. with 1×10(7) NIH:OVCAR-3 cells. After 3 weeks, they received PRIT (1.0 or 1.5 MBq), RIT (0.9 MBq), or no treatment. Concurrently, 10 additional animals were sacrificed and examined to determine disease......), and 0.45 (RIT). The 1.5-MBq PRIT group exhibited lower incidence of ascites and fewer tumors >1 mm than RIT-treated animals. Conclusions: PRIT was as effective as RIT with regard to TFF; however, the size distribution of tumors and presence of ascites indicated that 1.5-MBq PRIT was more efficient...

  10. Measurement of the (211)Pb half-life using recoil atoms from (219)Rn decay.

    Aitken-Smith, P M; Collins, S M

    2016-04-01

    The radioactive half-life of (211)Pb was measured, by α-particle counting of samples of radiochemically pure (211)Pb in equilibrium with its α-emitting progeny, (211)Bi and (211)Po. The samples were prepared by the collection of (215)Po recoil atoms from the decay of the (219)Rn decay progeny produced from a (223)Ra sample onto stainless steel discs. The radioactive decay of the (211)Pb was measured utilising a 2π proportional counter operating on the α plateau. A half-life of 36.164 (13)min was determined, which is in agreement with currently available literature. A full uncertainty budget is presented. A recommended half-life of T1/2((211)Pb)=36.161 (17)min has been evaluated from the current literature values. PMID:26773817

  11. Gene expression signature in mouse thyroid tissue after 131I and 211At exposure

    Rudqvist, Nils; Spetz, Johan; Schüler, Emil; Langen, Britta; Parris, Toshima Z.; Helou, Khalil; Forssell-Aronsson, Eva

    2015-01-01

    Background 131I and 211At are used in nuclear medicine and accumulate in the thyroid gland and may impact normal thyroid function. The aim of this study was to determine transcriptional profile variations, assess the impact on cellular activity, and identify genes with biomarker properties in thyroid tissue after 131I and 211At administration in mice. Methods To further investigate thyroid tissue transcriptional responses to 131I and 211At administration, we generated a new transcriptional da...

  12. Clinical significance of serum CYFRA 21-1 in gastric cancer.

    Nakata, B.; Chung, Y. S.; Kato, Y.; Ogawa, M; Ogawa, Y; Inui, A.; Maeda, K; Sawada, T; Sowa, M.

    1996-01-01

    We studied the clinical significance of the soluble cytokeratin 19 fragment detected with monoclonal antibody CYFRA 21-1 in the sera of patients with histologically proven gastric cancer. Sera of 110 patients with gastric cancer were analysed for CYFRA 21-1 levels by a two-step sandwich enzyme immunoassay. There were no significant differences between CYFRA 21-1 levels and the histotype, depth of invasion or vessel invasion. However, CYFRA 21-1 was significantly higher in the presence of peri...

  13. New tumor markers for breast carcinoma is serum CYFRA 21-1%乳腺癌新的肿瘤标志物-CYFRA21-1

    刘志勇; 欧阳忠; 邹小明

    2010-01-01

    目的 探讨CYFRA21-1在乳腺癌中的表达情况及其临床意义.方法 分别检测86例原发性乳腺癌,14例复发性乳腺癌,22例良性乳腺肿瘤,25例正常人群中血清CYFRA21-1、CEA、CA153的表达情况,并检测血清CYFRA21-1含量与临床病理特征、预后及无病生存时间的关系.结果 乳腺良性肿瘤人群与正常人群中CYFRA21-1的差别无统计学意义.CYFRA21-1在Ⅳ期乳腺癌及复发性乳腺癌中的阳性率分别为60%和64.2%,其阳性率高于CA153和CEA.在血运性复发性乳腺癌病例中,其灵敏度较高,为89%.随着TNM分期的增加CYFRA21-1的水平逐渐升高.CYFRA21-1与CEA无统计学关联,与CA153有轻度统计学关联,单因素及多因素分析均显示:CYFRA21-1可作为判断乳腺癌预后的一个独立指标.结论 检测CYFRA21-1水平对检测乳腺癌复发及评估治疗效果有非常大的价值.

  14. On convergence (2,1,...,1-periodic branched continued fraction of the special form

    D. I. Bodnar

    2016-01-01

    Full Text Available (2,1,...,1-periodic branched continued fraction of the special form is defined. Conditions of convergence are established for 2-periodic continued fraction and (2,1,...,1-periodic branched continued fraction of the special form. Truncation error bounds are estimated for these fractions under additional conditions.

  15. 48 CFR 552.211-92 - Radio Frequency Identification (RFID) using passive tags.

    2010-10-01

    ... with 48 CFR clause 252.211-7006. Shipments to GSA Distribution Centers with final destinations to DLA and DoD shall be in compliance to 48 CFR 252.211-7006. Copies may be obtained from http://www.access.gpo.gov/nara/cfr/cfr-table-search.html. (End of clause)...

  16. Alpha-Decay of $^{211}Po$ on the 1633 keV $^{207}Pb$ level

    Chumin, V G; Malikov, Sh R; Norseev, Yu V; Samatov, Z K; Fominykh, V I; Cherevatenko, A P; Yurkova, L V

    2000-01-01

    In investigations of gamma-spectrum of ^{211}At and daughter ^{211}Po and ^{207}Bi isotopes a new branch of the alpha-decay on the ^{207}Pb 1633 keV level is discovered. Its intensity is 8.1 cdot 10^{-4} %.

  17. 33 CFR 211.111 - Certification terminating rights of former owners.

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Certification terminating rights of former owners. 211.111 Section 211.111 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN...

  18. 45 CFR 400.211 - Methodology to be used to determine time-eligibility of refugees.

    2010-10-01

    ...-eligibility of refugees. 400.211 Section 400.211 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Federal Funding Federal Funding for Expenditures for...

  19. 12 CFR 211.22 - Interstate banking operations of foreign banking organizations.

    2010-01-01

    ... production office in accordance with the provisions in § 208.7 of Regulation H (12 CFR 208.7). ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Interstate banking operations of foreign banking organizations. 211.22 Section 211.22 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF...

  20. 12 CFR 211.23 - Nonbanking activities of foreign banking organizations.

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Nonbanking activities of foreign banking organizations. 211.23 Section 211.23 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM INTERNATIONAL BANKING OPERATIONS (REGULATION K) Foreign Banking Organizations §...

  1. 12 CFR 211.3 - Foreign branches of U.S. banking organizations.

    2010-01-01

    ... CFR part 204). (e) Conditional approval; access to information. The Board may impose such conditions... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Foreign branches of U.S. banking organizations. 211.3 Section 211.3 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL...

  2. 49 CFR 240.211 - Procedures for making the determination on performance skills.

    2010-10-01

    ... performance skills. 240.211 Section 240.211 Transportation Other Regulations Relating to Transportation... determination on performance skills. (a) Each railroad, prior to initially certifying or recertifying any person... demonstrated, in accordance with the requirements of § 240.127 of this part, the skills to safely...

  3. 49 CFR 375.211 - Must I have an arbitration program?

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Must I have an arbitration program? 375.211... Services to My Customers General Responsibilities § 375.211 Must I have an arbitration program? (a) You must have an arbitration program for individual shippers to resolve disputes about property loss...

  4. 40 CFR 600.211-08 - Sample calculation of fuel economy values for labeling.

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Sample calculation of fuel economy values for labeling. 600.211-08 Section 600.211-08 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES...

  5. 12 CFR 211.7 - Voluntary liquidation of Edge and agreement corporations.

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Voluntary liquidation of Edge and agreement corporations. 211.7 Section 211.7 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM INTERNATIONAL BANKING OPERATIONS (REGULATION K) International Operations of U.S....

  6. 5 CFR 842.211 - Senior Executive Service, Defense Intelligence Senior Executive Service, and Senior Cryptologic...

    2010-01-01

    ... Intelligence Senior Executive Service, and Senior Cryptologic Executive Service. 842.211 Section 842.211... Intelligence Senior Executive Service, and Senior Cryptologic Executive Service. (a) A member of the Senior Executive Service, the Defense Intelligence Senior Executive Service, or the Senior Cryptologic...

  7. Separation of 211At from irradiated bismuth target and labelling of a model protein

    Astatine-211 is a promising radionuclide for therapeutic use in nuclear medicine. An efficient method (70%) for radiochemical separation from the irradiated Bi-target has been described. The level of Bi contamination in the purified 2'11At-solution was estimated. Finally labelling of a model protein has been tried. (author). 14 refs

  8. Influence of preparation conditions on 211 particle refinement in YBCO bulk superconductors with Ce addition

    Diko, Pavel, E-mail: dikos@saske.sk; Volochová, Daniela; Radušovská, Monika; Zmorayová, Katarína; Šefčiková, Martina; Antal, Vitalij; Jurek, Karel; Jirsa, Miloš; Kováč, Jozef

    2013-11-15

    Highlights: •CeO{sub 2} causes coarsening of Y211 particles in nominal composition Y{sub 1.5}Ba{sub 2}Cu{sub 3}O{sub x}. •Y211 particles grow during sintering at 940 °C. •High local density of Y211 particles hinders their growth at sintering stage. •Addition of BaCeO{sub 3} leads to smaller Y211 particles. •Skeleton of Y211 particles prevents pollution of grown samples. -- Abstract: The influence of CeO{sub 2} and BaCeO{sub 3} addition and the influence of processing conditions on Y{sub 2}BaCuO{sub 5} (Y211) particle size and particle distribution in melt-processed YBa{sub 2}Cu{sub 3}O{sub 7}/Y{sub 2}BaCuO{sub 5} (Y123/Y211) bulk superconductors with nominal composition Y{sub 1.5}Ba{sub 2}Cu{sub 3}O{sub x} was investigated. Ce dissolved in the peritectic melt can actively hinder the Y211 particle growth by the Ostwald ripening process at melting stage. At sintering of intensively milled samples, Y211 particles in the charge free of CeO{sub 2} are smaller than Y211 particles formed in the charge with CeO{sub 2} addition and this behaviour can be related to the melt formation around added CeO{sub 2}. The Y211 particle refinement in the mildly milled samples with large Y123 particles in the pressed green bodies is caused by very dense Y211 skeleton resistant to melt formation at the sintering stage. This skeleton is a barrier for pollution of the sample from the substrate and from the seed. BaCeO{sub 3} added instead CeO{sub 2} causes significant Y211 particle refinement also in the samples with homogenously distributed Y211 particles.

  9. Prevalence of the prion protein gene E211K variant in U.S. cattle

    Chase Chad C

    2008-07-01

    Full Text Available Abstract Background In 2006, an atypical U.S. case of bovine spongiform encephalopathy (BSE was discovered in Alabama and later reported to be polymorphic for glutamate (E and lysine (K codons at position 211 in the bovine prion protein gene (Prnp coding sequence. A bovine E211K mutation is important because it is analogous to the most common pathogenic mutation in humans (E200K which causes hereditary Creutzfeldt – Jakob disease, an autosomal dominant form of prion disease. The present report describes a high-throughput matrix-associated laser desorption/ionization-time-of-flight mass spectrometry assay for scoring the Prnp E211K variant and its use to determine an upper limit for the K211 allele frequency in U.S. cattle. Results The K211 allele was not detected in 6062 cattle, including those from five commercial beef processing plants (3892 carcasses and 2170 registered cattle from 42 breeds. Multiple nearby polymorphisms in Prnp coding sequence of 1456 diverse purebred cattle (42 breeds did not interfere with scoring E211 or K211 alleles. Based on these results, the upper bounds for prevalence of the E211K variant was estimated to be extremely low, less than 1 in 2000 cattle (Bayesian analysis based on 95% quantile of the posterior distribution with a uniform prior. Conclusion No groups or breeds of U.S. cattle are presently known to harbor the Prnp K211 allele. Because a carrier was not detected, the number of additional atypical BSE cases with K211 will also be vanishingly low.

  10. 5 CFR 875.211 - What happens if my eligibility status changes after I submit my application?

    2010-01-01

    ... provisions of 5 U.S.C. 8412(g), or retire after you submit an application for coverage, but before your... changes after I submit my application? 875.211 Section 875.211 Administrative Personnel OFFICE OF... PROGRAM Eligibility § 875.211 What happens if my eligibility status changes after I submit my...

  11. Evaluation of meta-[211At]astatobenzylguanidine in an athymic mouse human neuroblastoma xenograft model

    A paired-label biodistribution was performed in athymic mice bearing SK-N-SH human neuroblastoma xenografts to compare the tissue uptake of meta-[211At]astatobenzylguanidine ([211At]MABG) and [131I]MIBG. Significantly higher (p 211At]MABG was seen in tumor (3.8 ± 0.8% ID/g vs. 3.1 ± 0.7% ID/g at 8 h) compared to [131I]MIBG. Desipramine reduced tumor uptake of [211At] MABG by 43%, suggesting that its accumulation was related to the specific uptake-1 mechanism. Higher uptake of [211At]MABG was also seen in normal tissue targets such as heart (6.0 ± 0.9% ID/g vs. 4.5 ± 0.8% ID/g at 8 h; p 211At]MABG by 1.5-fold while reducing uptake in heart and several other normal tissues. The vesicular uptake inhibitor tetrabenazine reduced heart uptake by 30% without reducing the tumor uptake. These results suggest such strategies might be useful for improving [211At]MABG tumor-to-normal tissue ratios

  12. Preparation and preclinical evaluation of 211At-labelled compounds for α-particle radiotherapy

    The interest for α-particle emitters in internal radiotherapy is increasing due to improved conjugation chemistry. Experimental work has concentrated on 211At and 212Bi since these to nuclides have radiochemical and physical properties suitable for medical application. In this report it is demonstrated that biologically active 211At-labelled compounds can be prepared within a relatively short time allowing utilization of this 7.2 h α-particle. It is further shown that 211At-TP-3 treatment of human osteosarcoma in vitro gives promising therapeutic ratios. 76 refs., 5 figs., 3 tabs

  13. CYFRA 21-1 serum levels in women with adnexal masses and inflammatory diseases.

    Tempfer, C; Hefler, L; Heinzl, H; Loesch, A.; Gitsch, G; Rumpold, H.; Kainz, C.

    1998-01-01

    The aim of the present study was to evaluate the clinical usefulness of the cytokeratin marker CYFRA 21-1 as a screening marker for ovarian cancer, as a predictive marker in patients with adnexal masses and as a prognostic marker in women suffering from ovarian cancer. In order to determine the specificity of the CYFRA 21-1 test, we have investigated CYFRA 21-1 serum levels in several benign conditions. This retrospective study comprises 37 patients suffering from ovarian cancer FIGO stages I...

  14. Preparation and preclinical evaluation of {sup 211}At-labelled compounds for {alpha}-particle radiotherapy

    Larsen, R.H.

    1994-12-31

    The interest for {alpha}-particle emitters in internal radiotherapy is increasing due to improved conjugation chemistry. Experimental work has concentrated on {sup 211}At and {sup 212}Bi since these to nuclides have radiochemical and physical properties suitable for medical application. In this report it is demonstrated that biologically active {sup 211}At-labelled compounds can be prepared within a relatively short time allowing utilization of this 7.2 h {alpha}-particle. It is further shown that {sup 211}At-TP-3 treatment of human osteosarcoma in vitro gives promising therapeutic ratios. 76 refs., 5 figs., 3 tabs.

  15. The growth and characterization of (211) and (133) Oriented (Hg,Cd)Te epilayers (211)B GaAs by organometallic vapor phase epitaxy

    Gouws, G. J.; Muller, R. J.

    1995-09-01

    The growth of CdTe buffer layers on (211)B GaAs substrates by organometallic vapor phase epitaxy (OMVPE) was studied, and it was found that, depending on the growth conditions, either the (211) or (133) epitaxial orientation could be formed. In some cases, an epilayer showing a mixed (211) and (133) orientation was also observed. The influence of several growth parameters on the orientation of the CdTe layer was investigated, and it was found that the Te/Cd ratio, together with the growth temperature, have the most significant effect in determining the epilayer orientation. From these results, it was then possible to select nominally optimized growth conditions for CdTe buffer layers of both orientations. (Hg,Cd)Te layers of the same orientations could then be grown and characterized. Although double crystal x-ray diffraction measurements indicated a somewhat better crystalline perfection in the (133) (Hg,Cd)Te layers, these layers showed a poor surface morphology compared to the (211) orientation. Measurement of etch pit densities also indicated defect densities to be typically half an order of magnitude higher in the (133) orientation. Diodes were formed by ion implantation in both orientations and significantly better results were obtained on the (211) (Hg,Cd)Te layers.

  16. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  17. Morphological stability of Sm123 superconductor during peritectic solidification from Sm211 + L mixture

    The interface stability of the Sm 123 superconductor was analyzed in accordance with the constitutional undercooling criterion. As the single-crystal growth of the 123 phase is largely dependent on the growth-interface stability, a quantitative analysis was very much required. From this analysis, it was clarified that the constitutional undercooling must exist in the liquid when the 123 growth interface comes close to a 211 particle during the peritectic solidification. It was also predicted that the larger 211 particle radius, smaller volume fraction of the 211 particles, larger growth rate, or smaller imposed temperature gradient would cause easy occurrence of the constitutional undercooling ahead of the 123 growth interface. Taking into account the nucleation at the L/211 interface just ahead of the 123 growth front due to the constitutional undercooling, the transition of 123 growth from a planar-interface morphology to an equiaxed blocky morphology was investigated quantitatively and qualitatively

  18. 33 CFR 211.8 - Limitations on rights which may be granted.

    2010-07-01

    ... ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Temporary Use by Others of Civil Works Real Estate § 211.8 Limitations on rights...

  19. System Engineering Management and Implementation Plan for Project W-211, ''Initial Tank Retrieval Systems'' (ITRS)

    This systems Engineering Management and Implementation Plan (SEMIP) describes the Project W-211 implementation of the Tank Farm Contractor Systems Engineering Management Plan (TFC SEMP). The SEMIP defines the systems engineering products and processes used by the project to comply with the TFC SEMP, and provides the basis for tailoring systems engineering processes by applying a graded approach to identify appropriate systems engineering requirements for W-211

  20. Increases in Serum CYFRA21-1 Concentration during Successful Treatment with Crizotinib

    Kanaji, Nobuhiro; Tadokoro, Akira; Watanabe, Naoki; Inoue, Takuya; Ishii, Tomoya; Dobashi, Hiroaki; Bandoh, Shuji

    2014-01-01

    Case series Patient: — Final Diagnosis: — Symptoms: — Medication: — Clinical Procedure: — Specialty: — Objective: Unexpected drug reaction Background: Increases in tumor marker concentrations usually suggest disease progression. Cases Report: We here describe on 3 patients with non-small cell lung cancer whose serum concentrations of CYFRA21-1 increased in spite of successful treatment with crizotinib. Discontinuation of crizotinib resulted in a rapid decrease in serum CYFRA21-1 concentration...

  1. Preparation and in vivo evaluation of linkers for 211At labeling of humanized anti-Tac

    The syntheses, radiolabeling, antibody conjugation, and in vivo evaluation of new linkers for 211At labeling of humanized anti-Tac (Hu-anti-Tac), an antibody to the α-chain of the IL-2 receptor (IL-2Rα) shown to be a useful target for radioimmunotherapy are described. Synthesis of the organometallic linker precursors is accomplished by reaction of the corresponding bromo- or iodoaryl esters with bis(tributyltin) in the presence of a palladium catalyst. Subsequent conversion to the corresponding N-succinimidyl ester and labeling with 211At of two new linkers, N-succinimidyl 4-[211At]astato-3-methylbenzoate and N-succinimidyl N-(4-[211At]astatophenethyl)succinamate (SAPS), together with the previously reported N-succinimidyl 4-[211At]astatobenzoate and N-succinimidyl 3-[211At]astato-4-methylbenzoate, are each conjugated to Hu-anti-Tac. The plasma survival times of these conjugates are compared to those of directly iodinated (125I) Hu-anti-Tac. The N-succinimidyl N-(4-[211At]astatophenethyl)succinamate compound (SAPS) emerged from this assay as the most viable candidate for 211At-labeling of Hu-anti-Tac. SAPS, along with the directly analogous radio-iodinated reagent, N-succinimidyl N-(4-[125I]astatophenethyl)succinamate (SIPS), are evaluated in a biodistribution study along with directly iodinated (125I) Hu-anti-Tac. Blood clearance and biological accretion results indicate that SAPS is a viable candidate for further evaluation for radioimmunotherapy of cancer

  2. Silver impregnated nanoparticles of titanium dioxide as carriers for {sup 211}At

    Cedrowska, Edyta; Lyczko, Monika; Piotrowska, Agata; Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Stolarz, Anna; Trcinska, Agnieszka [Warsaw Univ. (Poland). Heavy Ion Lab.; Szkliniarz, Katarzyna [Silesia Univ. Katowice (Poland). Inst. of Physics; Was, Bogdan [Polish Academy of Science, Cracow (Poland). Inst. of Nuclear Physics

    2016-08-01

    The {sup 211}At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of {sup 211}At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes {sup 211}At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of {sup 211}At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for {sup 211}At. Ag{sup +} cations have been absorbed on the nanometer-sized TiO{sub 2} particles (15 and 32 nm) through ion exchange process and were reduced in Tollens' reaction. The obtained TiO{sub 2}-Ag nanoparticles were labeled with {sup 211}At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make TiO{sub 2}/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the TiO{sub 2}/Ag surface.

  3. Preoperative CYFRA 21-1 level as a prognostic indicator in resected primary squamous cell lung cancer.

    Niklinski, J.; Furman, M; Burzykowski, T.; Chyczewski, L.; Laudanski, J.; Chyczewska, E; Rapellino, M.

    1996-01-01

    The CYFRA 21-1 assay is a test that has been developed recently for detection of a cytokeratin 19 fragment in serum. A diagnostic role for CYFRA 21-1 has already been proposed. The question of whether this marker is prognostically significant is important in clarifying the role of CYFRA 21-1 in clinical practice. The aim of this study was to evaluate the prognostic significance of elevated preoperative CYFRA 21-1 levels in patients with resected primary squamous-cell lung cancer (SqCC). Serum...

  4. Serum squamous cell carcinoma antigen and CYFRA 21-1 in cervical cancer treatment

    Purpose: To analyze whether serum squamous cell carcinoma (SCC) antigen and cytokeratin-19 fragments (CYFRA) levels can assist in selecting patients with locally advanced cervical cancer who will benefit from combined treatment or additive surgery. Methods and Materials: Of 114 patients with cervical cancer Stage IB-IV, the first 39 patients received radiotherapy, the following 75 patients received identical radiotherapy plus concomitant chemotherapy (3 cycles of carboplatin and 5-fluorouracil). SCC antigen and CYFRA 21-1 serum levels were measured before treatment, after therapy, and during follow-up. Baseline tumor markers were related to tumor stage and size and clinical outcome. Results: Before treatment, SCC antigen was elevated (>1.9 μg/L) in 60% and CYFRA 21-1 (>2.2 μg/L) in 46% of patients. For all patients, disease-free survival (DFS) was better after combined treatment (67% vs. 43%, p<0.0005). For patients with elevated baseline SCC antigen, DFS was better after combination therapy (67% vs. 27%, p=0.001) which resulted more frequently in a normal SCC antigen (93% vs. 65%, p=0.004). In contrast, in those with a normal baseline CYFRA 21-1, combined therapy resulted in a better DFS (p=0.04). Patients who achieved a normal SCC antigen or CYFRA 21-1 after treatment had a better DFS (respectively 63 vs. 17% and 64 vs. 30%). Elevated SCC antigen posttreatment indicated residual tumor in 11/12 patients (92%), elevated CYFRA 21-1 in 7/10 patients (70%). Forty-seven patients had a tumor recurrence. At recurrence, SCC antigen was raised in 70% and CYFRA 21-1 in 69%. Conclusions: In patients with an elevated pretreatment SCC antigen, SCC antigen normalized more frequently with combined treatment and those patients had a better DFS. Elevated SCC antigen or CYFRA 21-1 levels after treatment completion indicated residual tumor in respectively 92% and 70%. The presence of elevated posttreatment levels of SCC antigen or CYFRA 21-1 indicates the need for additional

  5. CYFRA 21-1 in urine: a diagnostic marker for endometriosis?

    Gjavotchanoff R

    2015-02-01

    Full Text Available Risto Gjavotchanoff1,2 1Department of Laboratory Medicine, Bodenseelabor, Hörbranz, Austria; 2Institute of Anatomy II, University of Jena, Jena University Hospital, Jena, Germany Abstract: Diagnostic workup of endometriosis usually involves laparoscopic inspection and histological examination of biopsies. Unequivocal laboratory parameters for this ailment have not been available in routine diagnostic evaluations thus far. In this study, we examined urine concentrations of cytokeratin 19 (CYFRA 21-1, a structural protein specific for epithelia. We performed immunoassays for CYFRA 21-1 in urine samples from women afflicted with endometriosis throughout their menstrual cycle. We observed a significant increase in CYFRA 21-1 concentrations, corrected by creatinine levels, in the late follicular phase as compared with the level in healthy controls. We conclude that cyclically increased CYFRA 21-1 concentrations in urine could serve as a valuable noninvasive diagnostic parameter in the workup of clinically manifesting endometriosis. Keywords: biomarkers, menstrual cycle, CYFRA 21-1, immunoassay, noninvasive diagnosis

  6. Hurdles for a Broader Use of 211At and for the Synthesis of 211At-Labelled Radiopharmaceuticals at High Activities for Clinical Use

    One of the key impediments to the use of 211At is the very well known deleterious effect of high radiation fields caused by its alpha particles on the synthesis of 211At-labelled radiopharmaceuticals. This is problematic because radiolysis-mediated effects can produce diminishing efficiency of electrophilic astatination reactions due to increasing deposition of radiation dose with increasing activities and with the passage of the time. Astatine-211 has chemical properties that permit complex labelling strategies and a longer half-life than 213Bi that makes it more suitable when the targeting molecule does not gain immediate access to the tumour cells. The first clinical evaluation was published in 2001 [2] in patients with brain tumour. Although this study circumvents many of the challenges to entering clinical studies with 211At and many obstacles had to be surmounted before clinical studies could be initiated, several problems were encountered in maintaining efficient labelling with escalating radiation dose of α-particle even with fresh 211At elution [3]. Astatine-211 also has an additional hurdle to overcome before to its clinical application in labelled radiopharmaceuticals related with its production and distribution. Among the potential group of promising α- emitter it is the only one produced by cyclotrons, but due to the scarcity of cyclotrons equipped with 25−30 MeV α-particle beams, it will of necessity be utilized in distant locations from the site of production. It presents a major chemical challenge because the diminishing efficiency of electrophilic astatination reactions with the passage of the time is well known, a problem likely related to the radiolysis produced by the high LET (linear energy transfer) meaning that large amounts of energy are deposited in a highly localized manner. This problem has been most comprehensively investigated to understand and evaluate the role of the radiolysis effects of astatine alpha particles in the synthesis

  7. Preparation and preclinical evaluation of 211At-labelled compounds for α-particle radiotherapy

    The present work demonstrate that significant therapeutic gain can be achieved with 211At-labelled MoAbs on single tumour cells and microscopic disease. Β-emitters are less effective on microscopic disease because of radiation dispersion, while longer halflives (e.g., 90Y and 131I) allow favourable therapeutic ratios to be reached in larger tumors. 211At-labelled MoAbs may therefore possibly be used in combination with β-emitting RIC in systemically delivered radioimunnotherapy. Larger tumor nodules are then irradiated effectively due to cross-fire of the longer ranged β-particles while the fraction of tumour cells distributed as single cells and micrometastases may be more effectively radiated with 211At-RIC. 76 refs

  8. Astatine-211: production, injection into monoclonal antibodies radiological effect, possible application to cancer treatment

    Methods developed in the Laboratory of Nuclear Problems, JINR, for producing astatine-211 and injecting it into monoclonal antibodies are described. The use of its diethylene triamine penta-acetic acid complex is shown to be the most effective method of injecting astatine into a biomolecules. The biological effect of the α-particles emitted from the astatine-211 is investigated using Chinese hamster fibroblasts and Ehrlich carcinoma cells. It is established that the mitotic activity depression, number of degenerating cells, number of cells with chromosome aberrations, and cellular surviving fraction depend on the concentration of the radionuclide in the medium 'in vitro'. The RBE of α-particles in comparison with 60Co γ-rays is 3. Injection of astatine-211 absorbed on tellurium particles into mice with ascitic tumors resulted in prolongation of their life or elimination of the tumors. (author). 39 refs, 7 figs

  9. Appraising nuclear octupole moment contributions to the hyperfine structures in $^{211}$Fr

    Sahoo, B K

    2015-01-01

    Hyperfine structures of $^{211}$Fr due to the interactions of magnetic dipole ($\\mu$), electric quadrupole ($Q$) and magnetic octupole ($\\Omega$) moments with the electrons are investigated using the relativistic coupled-cluster (RCC) theory with an approximation of singles, doubles and important valence triples excitations in the perturbative approach. Validity of our calculations are substantiated by comparing the results with their available experimental values. Its $Q$ value has also been elevated by combining the measured hyperfine structure constant of the $7p \\ ^2P_{3/2}$ state with our improved calculation. Considering the preliminary value of $\\Omega$ from the nuclear shell-model, its contributions to the hyperfine structures up to the $7d \\ ^2D_{5/2}$ low-lying states in $^{211}$Fr are estimated. Energy splittings of the hyperfine transitions in many states have been assessed to find out suitability to carry out their precise measurements so that $\\Omega$ of $^{211}$Fr can be inferred from them unam...

  10. Selective growth of CdTe on patterned CdTe/Si(211)

    Seldrum, T.; Bommena, R.; Samain, Louise; Sivananthan, S.; Sporken, R.; Dumont, J.

    2008-01-01

    The authors have studied selective growth of cadmium telluride on Si(211) by molecular beam epitaxy (MBE). Patterned substrates were produced by optical lithography of MBE-grown CdTe/As/Si(211). Photoemission microscopy was used as the main tool to study selective growth. This is very powerful because Si or SiO2 can be very easily distinguished from areas covered with even small amounts of CdTe due to contrast from work function differences. It was found that CdTe grows on CdTe without sticki...

  11. 8 CFR 211.3 - Expiration of immigrant visas, reentry permits, refugee travel documents, and Form I-551.

    2010-01-01

    ... permits, refugee travel documents, and Form I-551. 211.3 Section 211.3 Aliens and Nationality DEPARTMENT... Expiration of immigrant visas, reentry permits, refugee travel documents, and Form I-551. An immigrant visa, reentry permit, refugee travel document, or Form I-551 shall be regarded as unexpired if the...

  12. 12 CFR 211.601 - Status of certain offices for purposes of the International Banking Act restrictions on...

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Status of certain offices for purposes of the International Banking Act restrictions on interstate banking operations. 211.601 Section 211.601 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM INTERNATIONAL...

  13. 21 CFR 211.84 - Testing and approval or rejection of components, drug product containers, and closures.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Testing and approval or rejection of components, drug product containers, and closures. 211.84 Section 211.84 Food and Drugs FOOD AND DRUG... with filth, insect infestation, or other extraneous adulterant shall be examined against...

  14. 40 CFR 33.211 - What is the process for appealing or challenging an EPA MBE or WBE certification determination?

    2010-07-01

    ... challenging an EPA MBE or WBE certification determination? 33.211 Section 33.211 Protection of Environment... process for appealing or challenging an EPA MBE or WBE certification determination? (a) An entity which has been denied MBE or WBE certification by EPA OSDBU under § 33.205 or § 33.209 may appeal...

  15. 23 CFR 633.211 - Implementation of the Clean Air Act and the Federal Water Pollution Control Act.

    2010-04-01

    ... Pollution Control Act. Pursuant to regulations of the Environmental Protection Agency (40 CFR part 15) implementing requirements with respect to the Clean Air Act and the Federal Water Pollution Control Act are... Water Pollution Control Act. 633.211 Section 633.211 Highways FEDERAL HIGHWAY ADMINISTRATION,...

  16. 25 CFR 211.42 - Annual rentals and expenditures for development on leases other than oil and gas, and geothermal...

    2010-04-01

    ... other than oil and gas, and geothermal resources. 211.42 Section 211.42 Indians BUREAU OF INDIAN AFFAIRS... other than oil and gas, and geothermal resources. (a) Unless otherwise authorized by the Secretary, a lease for minerals other than oil, gas and geothermal resources shall provide for a yearly...

  17. Heteroepitaxy of CdTe on Ge(211)Substrates by Molecular Beam Epitaxy%Ge(211)衬底上分子束外延CdTe薄膜

    李艳辉; 杨春章; 苏栓; 谭英; 高丽华; 赵俊

    2011-01-01

    采用分子束外延在3英寸Ge(211)衬底上生长了10 μm厚的CdTe(211)B薄膜.CdTe表面镜面光亮,3英寸范围厚度平均值9.72 μm,偏差0.3 μm;薄膜晶体质量通过X射线双晶迴摆曲线进行评价,FWHM平均值80.23 arcsec,偏差3.03 arcsec; EPD平均值为4.5×106cm-2.通过研究CdTe薄膜厚度与FWHM和EPD的关系,得到CdTe的理想厚度为8~9 μm.%The 10μm thick CdTe(211)B has been grown by molecular beam epitaxy(MBE) on Ge(211) substrate. The surface morphology of CdTe layers with a diameter of three inches is smooth and mirror-like. The average of thick is 9.72 μm, deviation 0.3 μm; The crystalline quality was measured by an X-ray double-crystal rocking curve, the average is 80.23 arcsec, deviation 3.03 arcsec; The EPD is 4.5 × 106cm -2. We has studied the effects of the thickness onFWHM and EPD for CdTe layer, the optimum thickness of CdTe layer is 8~9 μm.

  18. Preparation of 211At-labeled humanized anti-Tac using 211At produced in disposable internal and external bismuth targets

    These studies describe the production and purification of 211At as well as the procedure for labeling humanized anti-Tac, the antibody to the α-chain of the IL-2 receptor (IL-2Rα), which has been shown to be a useful target for immunotherapy. The optimized protocol combines the advantages of the two-stage dry distillation procedure with the astatination of trialkylstannyl substances as labeling compounds for proteins. The 211At was produced by bombarding either an external or a recently developed disposable internal bismuth target with α-particles from a Cyclotron Corporation CS-30 cyclotron. The 211At was found to contain less than 0.01% 210At. The production rate for the external target was 0.15 mCi ± 0.056 μA-1 h-1 (n = 9) (5.55 MBq μA-1 h-1). The production rate for the internal target was 0.44 ± 0.14 mCi μA-1 h-1 (n = 16) (16.28 MBq μA-1 h-1)

  19. Cytokeratin 19 fragment antigen 21-1 as an independent predictor for definitive chemoradiotherapy sensitivity in esophageal squamous cell carcinoma

    YAN Hong-jiang; WANG Ren-ben; ZHU Kun-li; JIANG Shu-mei; ZHAO Wei; XU Xiao-qing; FENG Rui

    2012-01-01

    Background Patients with esophageal squamous cell carcinoma (ESCC) undergoing definitive chemoradiotherapy (CRT) seem to have a disparity in therapeutic response.The identification of CRT sensitivity-related clinicopathological factors would be helpful for selecting patients most likely to benefit from CRT.Cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) and carcinoembryonic antigen (CEA) have been reported as useful tumor markers for esophageal cancer.The aim of this study was to examine the predictive value of CYFRA21-1 in comparison with CEA and other clinicopathological factors in patients with ESCC treated with definitive CRT.Methods Pretreatment serum CYFRA21-1 and CEA levels were measured by immunoradiometric assays.The relationships between pretreatment clinicopathological factors and the efficacy of CRT were analyzed.Overall survival (OS) was estimated by univariate and multivariate analysis.Results The results from a univariate analysis indicated that the efficacy of CRT was significantly associated with the serum levels of CYFRA21-1 and CEA before treatment (P=0.001 and P=0.023,respectively).It also indicated that the efficacy of CRT was significantly associated with the pretreatment tumor location (P=0.041).By Logistic regression analysis,the independent predictive factor associated with efficacy of CRT was CYFRA21-1 (P=0.002).The OS of the patients with high CYFRA 21-1 levels was worse than that of those with low CYFRA21-1 levels (P=0.001).In multivariate analysis,a low level of CYFRA21-1 was the most significant independent predictor of good OS (P=0.007).Conclusions CEA and tumor location may be useful in predicting the sensitivity of ESCC to CRT.CYFRA21-1 may be an independent predictor for definitive CRT sensitivity in ESCC.

  20. Diagnosis Value of the Detection of CYFRA21-1 in Non-small Cell Lung Cancer

    Jundong GU

    2010-12-01

    Full Text Available Background and objective Cytokeratin-19 fragment (CYFRA21-1 is a soluble protein in serum, and may be a useful circulating tumor marker. The aim of this study is to investigate the diagnostic value of the peripheral blood CYFRA21-1 in non-small cell lung cancer (NSCLC. Methods The levels of peripheral blood CYFRA21-1 were detected in 107 patients with NSCLC and 51 patients with benign pulmonary diseases by enzyme linked immunosorbent assay, and ROC curve was used to analyse the results. Results Singificant difference of peripheral blood CYFRA21-1 levels was detected between the NSCLC group and benign pulmonary disease group (χ2=47.343, P < 0.001. At the threshold of 3.3 ng/mL, sensitivity and specificity of CYFRA21-1 as a serologic marker were 74.77% and 76.47%, respectively for any cancer. ROC curve showed that the under-curve area (AUC of CYFRA21-1 was 0.813 9. There was no significant difference of CYFRA21-1 between subtypes of NSCLC (χ2=0.450, P=0.799. The peripheral blood CYFRA21-1 level was elevated significantly in the patients with extensive disease (IIIb, IV compared with patients with limited disase (I, II, IIIb (χ2=7.057, P=0.008. Conclusion As a tumor marker CYFRA21-1 has relative high sensitivity and specificity for the diagnosis of NSCLC. Elevated peripheral blood CYFRA 21-1 levels were usually indicated extensive disease of NSCLC.

  1. 42 CFR 137.211 - How does a Self-Governance Tribe learn whether self-governance activities have resulted in...

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false How does a Self-Governance Tribe learn whether self-governance activities have resulted in savings as described in § 137.210. 137.211 Section 137.211 Public... OF HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Operational Provisions Savings § 137.211 How...

  2. Ground state charmed meson spectra for N_f=2+1+1

    Rae, T D

    2015-01-01

    We present a preliminary study of the charmed meson spectra using the electrically neutral subset of the new Budapest-Marseille-Wuppertal N_f=2+1+1 gauge configurations that utilise the 3-HEX smeared clover action. The analysis is performed with a focus on the hyperfine splitting.

  3. 7 CFR 330.211 - Labeling of plant pests for movement under permits.

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Labeling of plant pests for movement under permits... AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FEDERAL PLANT PEST REGULATIONS; GENERAL; PLANT PESTS; SOIL, STONE, AND QUARRY PRODUCTS; GARBAGE Movement of Plant Pests § 330.211 Labeling...

  4. 76 FR 2605 - Airworthiness Directives; Rolls-Royce plc RB211-Trent 800 Series Turbofan Engines

    2011-01-14

    ... Register published on April 11, 2000 (65 FR 19477-78). Discussion The European Aviation Safety Agency (EASA... Order 12866; 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR... Directives; Rolls-Royce plc RB211-Trent 800 Series Turbofan Engines AGENCY: Federal Aviation...

  5. 75 FR 15321 - Airworthiness Directives; Rolls-Royce plc RB211-Trent 800 Series Turbofan Engines

    2010-03-29

    ... Register on January 5, 2010 (75 FR 264). That NPRM proposed to correct an unsafe condition for the... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant...; AD 2010-06-14] RIN 2120-AA64 Airworthiness Directives; Rolls-Royce plc RB211-Trent 800...

  6. 41 CFR 302-3.211 - What is an allowance for overseas tour renewal travel?

    2010-07-01

    ... TYPE Types of Transfers Overseas Tour Renewal Agreement § 302-3.211 What is an allowance for overseas tour renewal travel? An allowance for overseas tour renewal travel is a reimbursement for you and your... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What is an allowance...

  7. 33 CFR 211.7 - Rights which may be granted by Division and District Engineers.

    2010-07-01

    ..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Temporary Use by Others of Civil Works Real Estate § 211.7 Rights which may... to which real estate functions have been or may be assigned are authorized to lease, in the name...

  8. 22 CFR 211.8 - Disposition of commodities unfit for authorized use.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Disposition of commodities unfit for authorized... COMMODITIES FOR FOOD USE IN DISASTER RELIEF, ECONOMIC DEVELOPMENT AND OTHER ASSISTANCE § 211.8 Disposition of commodities unfit for authorized use. (a) Prior to delivery to cooperating sponsor at discharge port or...

  9. 20 CFR 211.12 - Compensation credited for title VII benefits.

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Compensation credited for title VII benefits... RETIREMENT ACT CREDITABLE RAILROAD COMPENSATION § 211.12 Compensation credited for title VII benefits. Payments made to an employee under title VII of the Regional Rail Reorganization Act of 1973 are...

  10. The clinical utility of a new tumor marker for lung cancer Cyfra 21-1

    Cytokeratins expressed in epithelial cells from respiratory epithelium are also expressed in situ by lung cancers. The Cyfra 21-1 assay is a newly developed test which measures in serum fragments of cytokeratin 19. The aim of our study was to asses the clinical utility of the protein as a marker for lung cancer. We evaluated this marker in 196 patients with lung cancer , 33 patients with being lung diseases and 60 healthy individuals. Significantly higher levels were observed in patients with lung cancer but there was not difference between histological types of lung cancer. Concentration of Cyfra 21-1 significantly correlated with the stage of disease and the highest levels were found in patients with metastases. Consequently the marker was significantly lower in patients who were operated upon when compared with unresectable ones p,0.0001. In addition we observed a correlation between Cyfra 21-1 concentration and survival time. Cyfra 21-1 as a tumor marker is clinically useful especially for NSCLC. (author)

  11. Cyfra 21-1 als Follow-up-Tumormarker bei Patienten mit Plattenepithelkarzinom des Oropharynx

    Alkotyfa, Khaled

    2009-01-01

    Zusammenfassend kann festgestellt werden, dass die Erhebung der Cyfra 21-1- Konzentration im Serum wertvolle Hinweise vor allem hinsichtlich des Vorlegens von Fernmetastasen und Kontrolle des Therapieerfolges sowie des individuellen Krankheitsverlaufes geben kann. Die Resultate der vorliegenden Untersuchung zeigen, dass zum Zeitpunkt der Diagnosestellung keine eindeutige Korrelation zwischen dem Ausmaß der cervikalen Lymphknotenme...

  12. Whole genome analysis of Klebsiella pneumoniae T2-1-1 from human oral cavity

    Kok-Gan Chan

    2016-03-01

    Full Text Available Klebsiella pneumoniae T2-1-1 was isolated from the human tongue debris and subjected to whole genome sequencing on HiSeq platform and annotated on RAST. The nucleotide sequence of this genome was deposited into DDBJ/EMBL/GenBank under the accession JAQL00000000.

  13. A study of the wiggle morphology of HH 211 through numerical simulations

    Moraghan, Anthony; Lee, Chin-Fei; Huang, Po-Sheng; Vaidya, Bhargav

    2016-08-01

    Recent high-resolution, high-sensitivity observations of protostellar jets have shown many to possess deviations to their trajectories. HH 211 is one such example where sub-mm observations with the Submillimeter Array (SMA) have revealed a clear reflection-symmetric wiggle. The most likely explanation is that the HH 211 jet source could be moving as part of a protobinary system. Here, we test this assumption by simulating HH 211 through 3D hydrodynamic jet propagation simulations using the PLUTO code with a molecular chemistry and cooling module, and initial conditions based on an analytical model derived from SMA observations. Our results show the reflection-symmetric wiggle can be recreated through the assumption of a jet source perturbed by binary motion at its base, and that a regular sinusoidal velocity variation in the jet beam can be close to matching the observed knot pattern. However, a more complex model with either additional heating from the protostar, or a shorter period velocity pulsation may be required to account for enhanced emission near the source, and weaker knot emission downstream. Position-velocity diagrams along the pulsed jet beam show a complex structure with detectable signatures of knots and show caution must be exercised when interpreting radial velocity profiles through observations. Finally, we make predictions for future HH 211 observations with Atacama Large Millimeter Array.

  14. Astatination of nanoparticles containing silver as possible carriers of 211At

    Lebeda, Ondřej; Kučka, Jan; Hrubý, Martin; Koňák, Čestmír; Kozempel, Ján

    2006-01-01

    Roč. 64, - (2006), s. 201-206. ISSN 0969-8043 R&D Projects: GA AV ČR KJB4048302; GA AV ČR KJB4050408 Institutional research plan: CEZ:AV0Z1048901 Keywords : nanoparticles * 211AT * Atalpha particle therapy Subject RIV: CH - Nuclear ; Quantum Chemistry Impact factor: 0.924, year: 2006

  15. 30 CFR 77.211-1 - Continuous methane monitoring device; installation and operation; automatic deenergization of...

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Continuous methane monitoring device... Installations § 77.211-1 Continuous methane monitoring device; installation and operation; automatic deenergization of electric equipment. Continuous methane monitoring devices shall be set to...

  16. Whole genome analysis of Klebsiella pneumoniae T2-1-1 from human oral cavity

    Kok-Gan Chan; Wai-Fong Yin; Xin-Yue Chan

    2015-01-01

    Klebsiella pneumoniae T2-1-1 was isolated from the human tongue debris and subjected to whole genome sequencing on HiSeq platform and annotated on RAST. The nucleotide sequence of this genome was deposited into DDBJ/EMBL/GenBank under the accession JAQL00000000.

  17. Whole genome analysis of Klebsiella pneumoniae T2-1-1 from human oral cavity.

    Chan, Kok-Gan; Yin, Wai-Fong; Chan, Xin-Yue

    2016-03-01

    Klebsiella pneumoniae T2-1-1 was isolated from the human tongue debris and subjected to whole genome sequencing on HiSeq platform and annotated on RAST. The nucleotide sequence of this genome was deposited into DDBJ/EMBL/GenBank under the accession JAQL00000000. PMID:26981378

  18. 33 CFR 211.9 - Applications for leases, easements, licenses, and permits.

    2010-07-01

    ... WITH CIVIL WORKS PROJECTS Temporary Use by Others of Civil Works Real Estate § 211.9 Applications for leases, easements, licenses, and permits. Applications for use of Civil Works property should be made to the District Engineer of the district within the boundaries of which the real estate is located....

  19. 25 CFR 211.46 - Inspection of premises, books and accounts.

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Inspection of premises, books and accounts. 211.46... premises, books and accounts. Lessees shall allow the Indian mineral owner, the Indian mineral owner's... and submit all related reports required by the lease and applicable regulations. Books and...

  20. 21 CFR 211.184 - Component, drug product container, closure, and labeling records.

    2010-04-01

    ....84(d), or § 211.122(a)) and the conclusions derived therefrom. (c) An individual inventory record of each component, drug product container, and closure and, for each component, a reconciliation of the use of each lot of such component. The inventory record shall contain sufficient information to...

  1. A study of the wiggle morphology of HH 211 through numerical simulations

    Moraghan, Anthony; Lee, Chin-Fei; Huang, Po-Sheng; Vaidya, Bhargav

    2016-05-01

    Recent high-resolution high-sensitivity observations of protostellar jets have shown many to possess deviations to their trajectories. HH 211 is one such example where sub-mm observations with the SMA have revealed a clear reflection-symmetric wiggle. The most likely explanation is that the HH 211 jet source could be moving as part of a protobinary system. Here we test this assumption by simulating HH 211 through 3D hydrodynamic jet propagation simulations using the PLUTO code with a molecular chemistry and cooling module, and initial conditions based on an analytical model derived from SMA observations. Our results show the reflection-symmetric wiggle can be recreated through the assumption of a jet source perturbed by binary motion at its base, and that a regular sinusoidal velocity variation in the jet beam can be close to matching the observed knot pattern. However, a more complex model with either additional heating from the protostar, or a shorter period velocity pulsation may be required to account for enhanced emission near the source, and weaker knot emission downstream. Position velocity diagrams along the pulsed jet beam show a complex structure with detectable signatures of knots and show caution must be exercised when interpreting radial velocity profiles through observations. Finally, we make predictions for future HH 211 observations with ALMA.

  2. 18 CFR 367.2110 - Account 211, Miscellaneous paid-in capital.

    2010-04-01

    ... NATURAL GAS ACT Balance Sheet Chart of Accounts Proprietary Capital § 367.2110 Account 211, Miscellaneous..., Miscellaneous paid-in capital. 367.2110 Section 367.2110 Conservation of Power and Water Resources FEDERAL... ACT OF 2005, FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED...

  3. 48 CFR 2852.211-70 - Brand-name or equal.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Brand-name or equal. 2852... Forms SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 2852.211-70 Brand-name or equal. As prescribed in 2811.104-70, insert the following clause: Brand-Name or Equal (JAN...

  4. Improving Student Success in Principles of Accounting 211 with the Integration of Situational Leadership Methods.

    Ewell, Paul L.

    2001-01-01

    Looks at the failure rate of students in Accounting 211 in the Virginia Community College System. States that rote teaching styles that do not incorporate interdisciplinary and other diverse methods, do not take into account developing learning skills, and do not encourage active learning are doomed to fail. Makes recommendations for new…

  5. 21 CFR 211.46 - Ventilation, air filtration, air heating and cooling.

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Ventilation, air filtration, air heating and... Buildings and Facilities § 211.46 Ventilation, air filtration, air heating and cooling. (a) Adequate... holding of a drug product. (c) Air filtration systems, including prefilters and particulate matter...

  6. Whole genome analysis of Klebsiella pneumoniae T2-1-1 from human oral cavity

    Kok-Gan Chan; Wai-Fong Yin; Xin-Yue Chan

    2016-01-01

    Klebsiella pneumoniae T2-1-1 was isolated from the human tongue debris and subjected to whole genome sequencing on HiSeq platform and annotated on RAST. The nucleotide sequence of this genome was deposited into DDBJ/EMBL/GenBank under the accession JAQL00000000.

  7. 211At-Rh(16-S4-diol) complex as a precursor for astatine radiopharmaceuticals

    211At is one of the most promising radionuclides in α-radioimmunotherapy (α-RIT). Unfortunately, biomolecules labeled by direct electrophilic astatination are unstable due to the rapid loss of 211At under both in vitro and in vivo conditions. The present paper describes the results of our studies on attaching At- to the rhodium(III) complex with thioether ligand: 1,5,9,13-etrathiacyclohexadecane-3,11-diol (16-S4-diol). Rh3+ was chosen as a moderately soft metal cation which should form very strong bonds with soft At- anions, but first of all because of the kinetic inertness of low spin rhodium(III) d6 complexes. The 16-S4-diol ligand was selected due to formation of stable complexes with Rh3+. The experiments related to optimization of the reaction conditions were performed with the 131I, basing on a chemical similarity of I- to At-. The experiments with 211At were then carried out under the conditions found optimal for I-. The preliminary results are promising, and indicate a possibility for astatination of biomolecules by using the 211At-Rh(16-S4-diol) complex

  8. A new internal target system for production of 211At on the cyclotron U-120M

    Lebeda, Ondřej; Jiran, Rudolf; Ráliš, Jan; Štursa, Jan

    2005-01-01

    Roč. 63, - (2005), s. 49-53. ISSN 0969-8043 R&D Projects: GA AV ČR KJB4048302 Institutional research plan: CEZ:AV0Z10480505 Keywords : radionuclides production * 211At * cyclotron Subject RIV: CH - Nuclear ; Quantum Chemistry Impact factor: 0.757, year: 2005

  9. 12 CFR 211.45 - Accounting for fees on international loans.

    2010-01-01

    ... accordance with generally accepted accounting principles. Interpretations ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Accounting for fees on international loans. 211... Accounting for fees on international loans. (a) Restrictions on fees for restructured international loans....

  10. 5 CFR 847.211 - Death of employee during election opportunity period.

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Death of employee during election... Qualifying Move § 847.211 Death of employee during election opportunity period. (a) When an employee eligible... employee is deemed to have made the election and to be covered, at time of death, by the retirement...

  11. Clinical Usefulness of Serum CYFRA 21-1 in Patients with Colorectal Cancer

    Among diverse tumor markers, pretreatment evaluation and follow-up detection of recurrence in colorectal cancer are generally evaluated by serum carcinoembryonic antigen (CEA) levels. However, there have been some reports about the low accuracy and high false-positive results of CEA in colorectal cancer. We investigated the clinical utilities of CYFRA 21-1 by comparing CEA and cancer antigen 19-9 (CA 19-9) in pretreatment and recurrent colorectal cancer. Using a solid-phase immunoradiometric assay, serum levels of CYFRA 21-1, CEA and CA 19-9 were analyzed in 132 patients with primary colorectal cancer, 124 healthy controls, 104 patients with benign colorectal disease and 19 patients with recurrent colorectal cancer. We determined three different cutoff values to evaluate the sensitivity of diagnostic performance in pretreatment and recurrent colorectal cancer. CYFRA 21-1 (≥ 1.13 ng/ml) had a sensitivity of 47 %, compared with 37 % for CEA (≥ 3.05 ng/ml) and 32.6 % for CA 19-9 (≥ 23.1 ng/ml) in the initial staging of primary colorectal cancer. Using different cutoff values, CYFRA 21-1 showed higher sensitivity for pretreatment colorectal cancer than CEA and CA 19-9 in adenocarcinoma and adenosquamous carcinoma of this study. A mildly significant correlative relationship was noted between Dukes' stages and three tumor markers (p<0.01). The areas under the receiver operating characteristic curves of CYFRA 21-1, CEA and CA 19-9 were 0.81±0.03, 0.74±0.03 and 0.62 0.04, respectively, for discriminating colorectal cancer patients from patients with benign colorectal disease. In addition, CYFRA 21-1 was determined as the most sensitive tumor marker for evaluating recurrent colorectal cancer for all cutoff values. This study showed that CYFRA 21-1 could be a useful and dependable tumor marker for pretreatment and recurrent colorectal cancer. Further prospective studies on its usefulness with respect to the prognosis and utility of combined tumor markers are needed

  12. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven

  13. Hexavalent chromium removal and bioelectricity generation by Ochrobactrum sp. YC211 under different oxygen conditions.

    Chen, Chih-Yu; Cheng, Chiu-Yu; Chen, Ching-Kuo; Hsieh, Min-Chi; Lin, Ssu-Ting; Ho, Kuo-Ying; Li, Jo-Wei; Lin, Chia-Pei; Chung, Ying-Chien

    2016-01-01

    Bioremediation is an environmentally friendly method of reducing heavy metal concentration and toxicity. A chromium-reducing bacterial strain, isolated from the vicinity of an electroplate factory, was identified as Ochrobactrum sp. YC211. The efficiency and capacity per time of Ochrobactrum sp. YC211 for hexavalent chromium (Cr(VI)) removal under anaerobic conditions were superior to those under aerobic conditions. An acceptable removal efficiency (96.5 ± 0.6%) corresponding to 30.2 ± 0.8 mg-Cr (g-dry cell weight-h)(-1) was achieved by Ochrobactrum sp. YC211 at 300 mg L(-1) Cr(VI). A temperature of 30°C and pH 7 were the optimal parameters for Cr(VI) removal. By examining reactivated cells, permeabilized cells, and cell-free extract, we determined that Cr(VI) removal by Ochrobactrum sp. YC211 under anaerobic conditions mainly occurred in the soluble fraction of the cell and can be regarded as an enzymatic reaction. The results also indicated that an Ochrobactrum sp. YC211 microbial fuel cell (MFC) with an anaerobic anode was considerably superior to that with an aerobic anode in bioelectricity generation and Cr(VI) removal. The maximum power density and Cr(VI) removal efficiency of the MFC were 445 ± 3.2 mW m(-2) and 97.2 ± 0.3%, respectively. Additionally, the effects of coexisting ions (Cu(2+), Zn(2+), Ni(2+), SO4(2-), and Cl(-)) in the anolyte on the MFC performance and Cr(VI) removal were nonsignificant (P > 0.05). To our knowledge, this is the first report to compare Cr(VI) removal by different cells and MFC types under aerobic and anaerobic conditions. PMID:26889692

  14. Preparation and in vivo evaluation of a novel stabilized linker for 211At labeling of protein

    Significant improvement of in vivo stability of 211At-labeled radioimmunoconjugates achieved upon employment of a recently reported new linker, succinimidyl N-2-(4-[211At]astatophenethyl)succinamate (SAPS), prompted additional studies of its chemistry. The 211At radiolabeling of succinimidyl N-2-(4-tributylstannylphenethyl)succinamate (1) was noted to decline after storage at -15oC for greater than 6 months. Compound 1 was found to degrade via a ring closure reaction with the formation of N-2-(4-tributylstannylphenethyl)succinimide (3), and a modified procedure for the preparation of 1 was developed. The N-methyl structural analog of 1, succinimidyl N-2-(4-tributylstannylphenethyl)-N-methyl succinamate (SPEMS), was synthesized to investigate the possibility of improving the stability of reagent-protein linkage chemistry. Radiolabeling of SPEMS with 211At generates succinimidyl N-2-(4-[211At]astatophenethyl)-N-methyl succinamate (Methyl-SAPS), with yields being consistent for greater than 1 year. Radiolabelings of 1 and SPEMS with 125I generated succinimidyl N-2-(4-[125I]iodophenethyl)succinamate (SIPS) and succinimidyl N-2-(4-[125I]iodophenethyl)-N-methyl succinamate (Methyl-SIPS), respectively, and showed no decline in yields. Methyl-SAPS, SAPS, Methyl-SIPS and SIPS were conjugated to Herceptin for a comparative assessment in LS-174T xenograft-bearing mice. The conjugates of Herceptin with Methyl-SAPS or Methyl-SIPS demonstrated immunoreactivity equivalent to if not superior to the SAPS and SIPS paired analogs. The in vivo studies also revealed that the N-methyl modification resulted in a superior statinated product

  15. Keratin 19-positive cutaneous squamous cell carcinoma with elevated serum cytokeratin 19 fragment 21-1 level: A case report

    UEDA, MISATO; YASUDA, MICHINORI; SHIBAOKA, YOSHIE; KUROKAWA, ICHIRO; KAKUNO, AYAKO; TSUBURA, AIRO

    2016-01-01

    cytokeratin 19 fragment 21-1 (CYFRA21-1) is a marker of lung cancer useful for evaluating clinical diagnosis and prognosis. To the best of our knowledge, there have been no reports of cutaneous squamous cell carcinoma (SCC) with high levels of CYFRA21-1 to date. We herein report a case of a 79-year-old man with a large subcutaneous tumor of the left shoulder, which was diagnosed as primary cutaneous poorly differentiated SCC. The tumor nests were composed of poorly differentiated atypical squamous cells exhibiting high-grade malignancy and mitotic figures; multinuclear cells were also identified inside lymph vessels. Keratin 19 (K19) was intensely expressed in tumor cells. A significantly elevated level of CYFRA21-1 (33 ng/ml) was observed preoperatively. After surgery, the level of CYFRA21-1 was significantly decreased (from 33 to 5.0 ng/ml). Our case demonstrated that K19-positive primary cutaneous undifferentiated SCC induced high levels of CYFRA21-1 in the serum. Thus, CYFRA 21-1 may be a marker indicative of poorly differentiated cutaneous SCC exhibiting K19 expression.

  16. Fine-Needle Aspirate CYFRA 21-1, an Innovative New Marker for Diagnosis of Axillary Lymph Node Metastasis in Breast Cancer Patients

    Choi, Ji Soo; Han, Kyung Hwa; Kim, Eun-Kyung; Moon, Hee Jung; Yoon, Jung Hyun; Kim, Min Jung

    2015-01-01

    Abstract To compare the value of cytokeratin fragment 21-1 (CYFRA 21-1) concentration in the fine-needle biopsy aspirates (fine needle aspirate [FNA] CYFRA 21-1) with cytopathology of fine-needle aspiration biopsy (FNA cytology) and to assess whether CYFRA 21-1 concentrations from ultrasound-guided fine-needle aspiration biopsy (US-FNAB) specimens (FNA CYFRA 21-1) is not inferior to FNA cytology in the diagnosis of axillary lymph node (ALN) metastasis of breast cancer patients. This study rec...

  17. Diagnosis Value of the Detection of CYFRA21-1 in Non-small Cell Lung Cancer

    Gu, Jundong; Wang, Xinzhuo; Zhao, Hui; Zhu, Siwei; Yanjun WEN; Hongrui XU; LI Li; Jun CHEN; Zhou, Qinghua

    2010-01-01

    Background and objective Cytokeratin-19 fragment (CYFRA21-1) is a soluble protein in serum, and may be a useful circulating tumor marker. The aim of this study is to investigate the diagnostic value of the peripheral blood CYFRA21-1 in non-small cell lung cancer (NSCLC). Methods The levels of peripheral blood CYFRA21-1 were detected in 107 patients with NSCLC and 51 patients with benign pulmonary diseases by enzyme linked immunosorbent assay, and ROC curve was used to analyse the results. Res...

  18. Keratin 19-positive cutaneous squamous cell carcinoma with elevated serum cytokeratin 19 fragment 21-1 level: A case report

    UEDA, MISATO; YASUDA, MICHINORI; SHIBAOKA, YOSHIE; Kurokawa, Ichiro; Kakuno, Ayako; TSUBURA, AIRO

    2016-01-01

    cytokeratin 19 fragment 21-1 (CYFRA21-1) is a marker of lung cancer useful for evaluating clinical diagnosis and prognosis. To the best of our knowledge, there have been no reports of cutaneous squamous cell carcinoma (SCC) with high levels of CYFRA21-1 to date. We herein report a case of a 79-year-old man with a large subcutaneous tumor of the left shoulder, which was diagnosed as primary cutaneous poorly differentiated SCC. The tumor nests were composed of poorly differentiated atypical squ...

  19. ELECTRONIC PROPERTIES OF InSb(211)A,B SURFACES%InSb(211)A,B表面电子结构特性

    贾瑜; 陈国剑; 马丙现; 胡行; 顾华伟; 李新建

    2000-01-01

    采用散射理论的格林函数方法计算了InSb(211)A,B两类表面的电子结构,分别给出了两类表面的表面投影能带结构,分析了各表面态的轨道特性和色散特性;并在此基础上讨论了两类表面的稳定性;计算结果和实验结果定性的相符合.

  20. Cyfra211DT、CEADT结合影像学早期诊断肺癌复发与转移%Cyfra211, Serum CEA Doubling Time and Early Diagnosis of Recurrence and Metastasis of Lung Cancer Imaging Dynamics

    田荣华; 查云飞

    2013-01-01

    Objective To evaluate serum Cyfra211 ,CEA and their doubling time and imaging on recurrence and metastasis of lung cancer early diagnosis. Methods 152 cases of lung cancer patients,two years into three groups according to the condition, stable group 79 examples,recurrence in 31 cases of group, transfer group 42 cases. All objects half year 2-5 times serum Cy-fra211 determination,CEA,at the same time,CEADT Cyfra211DT calculation. The ROC Curve process ROC curves multivariable analysis,and with the single variable ROC curves for comparison,the track two years imaging findings,assessment Cyfra211 ,CEA and doubling time alone detection and four index united detection and imaging diagnosis lung cancer in dynamic changes the value of recurrence and metastasis. Results Cyfra211DT,CEADT in relapse and metastasis were the best for 136 days,the critical value of 153 days, 143 days, 132 days. Relapse and metastasis group Cyfra211,CEA and serum doubling time and stable group sensitivity and specificity were in significant differences. Conclusion Cyfra211DT and CEADT were better than Cyfra211 and serum CEA,four joint detection with imaging dynamic observation was helpful for early diagnosis of recurrence and metastasis.%目的 评价血清Cyfra211、CEA及其倍增时间与影像学动态变化对肺癌复发与转移的早期诊断价值.方法 152例肺癌患者,2年内按病情分为3组,稳定组79例,复发组31例,转移组42例.所有对象半年内2~5次测定血清Cyfra211、CEA,同时计算Cyfra211 DT、CEADT.采用ROC Curve过程进行多变量ROC曲线分析,并且与各单变量ROC曲线做比较,追踪两年内影像学表现,评价应用Cyfra211、CEA及其倍增时间单独检测和四指标联合检测以及影像学动态变化在诊断肺癌复发与转移中的价值.结果 Cyfra211 DT、CEADT在复发和转移中最佳临界值分别为136 d、153 d,143 d,132 d.复发和转移组血清Cyfra211、CEA及其倍增时间与稳定组中灵敏性和特异

  1. Sodium-iodide symporter (NIS)-mediated accumulation of [211At]astatide in NIS-transfected human cancer cells

    The cellular expression of the sodium iodide symporter (NIS) has been shown to confer iodide-concentrating capacity in non-thyroid cell types. We examined the role of NIS in the uptake of the alpha-particle emitting radiohalide [211At]astatide in the UVW human glioma cell line transfected to express NIS. [211At]Astatide uptake is shown to be NIS-dependent, with characteristics similar to [131I]iodide uptake. These studies suggest [211At]astatide as a possible alternative radionuclide to [131I]iodide for NIS-based endoradiotherapy, and provide a model for the study of [211At]astatide behavior at a cellular level

  2. Quantitation of 211At in small volumes for evaluation of targeted radiotherapy in animal models

    We have evaluated SPECT and two planar imaging methods, geometric mean (GM) and buildup factor (BF), for their potential to quantitate in vivo 211At distributions in rat spinal subarachnoid spaces using phantom studies. The use of medium-energy collimators and the small diameter (3 mm) of the subarachnoid space complicate quantitation. Net activities from distributions in various backgrounds were obtained using a large region of interest with background subtraction. Results showed quantitation accuracy within 10% for SPECT and BF in low backgrounds increasing to 25% at higher background levels while GM errors ranged from 20 to 45%. We have also obtained images of [211At]astatide distributions, administered intrathecally, in rats

  3. Electron transport and cyclotron resonance in (211)-oriented HgTe--CdTe superlattices

    Hoffman, C.A.; Meyer, J.R.; Wagner, R.J.; Bartoli, F.J. (Naval Research Laboratory, Washington, D. C. 20375 (USA)); Chu, X.; Faurie, J.P. (University of Illinois at Chicago, Chicago, Illinois 60680 (USA)); Ram-Mohan, L.R.; Xie, H. (Worcester Polytechnic Institute, Worcester, Massachusetts 01609 (USA))

    1990-03-01

    We discuss a magnetotransport and magneto-optical investigation of (211)-oriented HgTe--CdTe superlattices. Measurements were performed on seven {ital n}-type samples with well widths in the range 41--125 A and energy gaps between 0 and 128 meV. Both magnetotransport and magneto-optical results give evidence for an additional electron species besides the superlattice electrons and holes usually observed. We show that although these have quasi-two-dimensional character, their mobilities are quite sensitive to the superlattice well thickness. These findings are interpreted in terms of band bending and charge transfer from the CdTe substrate into the superlattice. We also discuss the first theoretical calculations of the band structure for (211)-oriented HgTe--CdTe heterostructures.

  4. Synthesis of (2-[11C]Methoxy)rotenone, a marker of mitochondrial complex I activity

    Recent studies suggest that defects in the function of the complexes of the electron transport chain might be involved in the pathology of neurological diseases such as mitochondrial encephalopathies, Parkinson's Huntington's and Alzheimer's disease. Rotenone is a potent reversible competitive inhibitor of complex I (NADH-CoQ reductase). To study the possible involvement of complex I in such diseases, we synthesized (2-[11C]methoxy)rotenone by [11C]alkylation of 2-O-desmethyl rotenone methyl enol ether followed by hydrolysis of the enol ether to the ketone using aqueous trifluoroacetic acid. (2-[11C]Methoxy)rotenone was purified by high pressure liquid chromatography (silica gel) and was obtained in 7-10% yields decay corrected to end of bombardment in synthesis times typically shorter than 48 min. Radiochemical purities were over 95% and specific activities averaged 1000 Ci/mmol at end of synthesis

  5. Shelf-Life of ɛ-Lysyl-3-(Trimethylstannyl)Benzamide Immunoconjugates, Precursors for 211At Labeling of Antibodies

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per; Jensen, Holger; Holgersson, Stellan; Lindegren, Sture

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity and the complex radiochemistry of 211At are major obstacles for research and prospective clinical applications. In the present study, astatination of immunoconjugates, already prepared well in advance...

  6. 76 FR 65997 - Airworthiness Directives; Rolls-Royce plc (RR) RB211-535 Series Turbofan Engines

    2011-10-25

    ...-08, Amendment 39-16707 (76 FR 30529, May 26, 2011), and adding the following new AD: Rolls-Royce plc..., Amendment 39-16707 (76 FR 30529, May 26, 2011). (c) Applicability This AD applies to Rolls-Royce plc RB211... (76 FR 30529, May 26, 2011), for all RR RB211-535E4-37, -535E4-B-37, -535E4-B- 75, and...

  7. An improved synthesis of an 125I and 211At labelled benzamide for melanoma imaging

    Recent studies have indicated that benzamides can exhibit affinity for malignant melanoma and may be exploited diagnostically in the treatment of this cancer. Radioiodinated N-(2-diethylaminoethyl)-3-[123I/131I]iodo-4-methoxybenzamide (*I-IMBA) is a benzamide with promising diagnostic properties. A new synthesis procedure was developed to obtain 125I-IMBA suitable for use in vivo. The assets of the procedure include the use of less toxic reagents and better reproducible results when radiolabelling the precursor. The procedure also facilitates the synthesis of the astatinated N-(2-diethylaminoethyl)-3-[211At]astatine-4-methoxybenzamide (211At-AMBA), a new benzamide with a therapeutic potential. The regiospecific no-carrier-added 125I- and 211At-labeling of the benzamide is performed by demetalation of an organotin precursor. Using tributylstannyl as a leaving group, the radiochemical yield obtained after 15 minutes of reaction was 70 %-90 % for both 125I-IMBA and 211At-AMBA. The labelling was performed in a solution of MeOH:AcOH with NCS as the oxidising agent. The organotin precursor N-(2-diethylaminoethyl)-3-(tri-n-butylstannyl)-4-methoxy-benzamide was synthesized from 3-bromo-4-methoxybenzoic acid, with n-BuLi (2 eq) and Bu3SnCl (1 eq) in THF, giving 3-(tri-n-butylstannyl)-4-methoxybenzoic acid. The amide function was introduced by converting the acid group into an active N-succinimidyl-ester, a good leaving group in the reaction with 2-(diethylamino)ethylamine. The overall yield of the organotin precursor was 65 %

  8. Status of ETMC simulations with Nf=2+1+1 twisted mass fermions

    We present the status of runs performed in the twisted mass formalism with Nf=2+1+1 flavours of dynamical fermions: a degenerate light doublet and a mass split heavy doublet. The procedure for tuning to maximal twist is described as well as the current status of the runs using both thin and stout links. Preliminary results for a few observables obtained on ensembles at maximal twist are given. Finally, a reweighting procedure to tune to maximal twist is described. (orig.)

  9. Effect of 211At treating pollen and stigma on generative cells and seed setting of rice

    JinJian-Nan; ChenFang; 等

    1998-01-01

    Low specific radioactivity (7.4kBq/ml) 211At treating pollen and stigma can obviously affect morphological structures and physiological functions of pollen,stigma and ovule or embryo sac cells,and cause injury.Results showed that because of the radiation effects the seed setting rate of rice was decreased,and the development of some embryos were affected and others became abnormal.

  10. Differentialdiagnose beim Lungenkarzinom durch CEA, CYFRA 21-1, NSE und ProGRP

    Gruber, Christine

    2008-01-01

    Es handelt sich um eine bizentrische, retrospektive Studie am Institut für Klinische Chemie am Klinikum Großhadern, München und an der Asklepioslungenfachklinik Gauting. Anhand von insgesamt 2749 Patienten wurde univariat und multivariat analysiert, inwieweit die Tumormarker CEA, CYFRA 21-1, NSE und ProGRP und zusätzlich die Routinelaborparameter eine Hilfestellung sowohl in der Diagnostik und Differentialdiagnostik eines Lungenrundherdes (benigne Lungenerkrankung, primäres Lungenkarzinom, Lu...

  11. η,η' mesons in 2+1+1 twisted mass lattice QCD

    The twisted mass formulation of lattice QCD is a framework for simulations with an even number of dynamical quarks which benefits from automatic O(a) improvement. Analysing suitable correlation functions, we focus on the mass splitting between the η and η' meson and related quantities in a setup with 2+1+1 dynamical quarks. In addition to the unitary setup, a different regularization of valence and sea quarks (Osterwalder-Seiler approach) is employed to study the strange quark mass dependence.

  12. Nucleon matrix elements with Nf=2+1+1 maximally twisted fermions

    We present a lattice calculation of nucleon matrix elements using four dynamical flavors using the Nf=2+1+1 maximally twisted mass formulation. The renormalization is performed non-perturbatively in the RI'-MOM scheme. We give results for the vector and axial vector operators with up to one-derivative and put particular emphasis on systematic effects in the calculation of the matrix elements.

  13. Global Organic Food & Beverages Market to Reach USD 211.44 Billion by 2020

    Haakon, Johnson

    2014-01-01

    Global organic food & beverages market is expected to reach USD 211.44 billion by 2020, growing at a CAGR of 15.7% from 2014 to 2020. Growing adoption of organic food & beverages owing to associated health benefits and eco-friendly characteristics is expected to drive demand over the next six years. In addition, regulatory support for organic farming is also expected to have a positive influence on the market by improving supply and product quality.

  14. Project Specific Quality Assurance Plan Project (QAPP) W-211 Initial Tank Retrieval Systems (ITRS)

    This Quality Assurance Program Plan (QAPP) provides information on how the Project Hanford Quality Assurance Program is implemented by CH2M HILL Hanford Group Inc (CHG) for managing the Initial Tank Retrieval Systems (ITRS), Project W-211. This QAPP is responsive to the CHG Quality Assurance Program Description (QAPD) (LMH-MP-599) which provides direction for compliance to 10 CFR 830 120, ''Nuclear Safety Management, Quality Assurance Requirements'', and DOE Order 5700 6C, ''Quality Assurance'' Project W-211 modifies existing facilities and provides systems for retrieval of radioactive wastes from selected double-shell tanks (DST). The contents of these tanks are a combination of supernatant liquids and settled solids. To retrieve waste from the tanks, it is first necessary to mix the liquid and solids prior to transferring the slurry to alternative storage or treatment facilities. The ITRS will provide systems to mobilize the settled solids and transfer the wastes out of the tanks. In so doing, ITRS provides feed for future processing plants, allows for consolidation of tank solids to manage space within existing DST storage capacity, and supports continued safe storage of tank waste. This project includes the design, procurement, construction, startup and turnover of these retrieval systems This QAPP identifies organizational structures and responsibilities. Implementing procedures used by CHG project management can be found in the CHG Quality Assurance Program (CHG QAP) Implementation Matrix located in HNF-IP-0842, Volume XI, Attachment Proposed verification and inspection activities for critical items within the scope of project W-211 are identified in Attachment 1 W-211. Project participants will identify the implementing procedures used by their organization within their QAF'Ps. This project specific QAPP is used to identify requirements in addition to the QAPD and provide, by reference, additional information to other project documents

  15. A study of the wiggle morphology of HH 211 through numerical simulations

    Moraghan, Anthony; Huang, Po-Sheng; Vaidya, Bhargav

    2016-01-01

    Recent high-resolution high-sensitivity observations of protostellar jets have shown many to possess deviations to their trajectories. HH 211 is one such example where sub-mm observations with the SMA have revealed a clear reflection-symmetric wiggle. The most likely explanation is that the HH 211 jet source could be moving as part of a protobinary system. Here we test this assumption by simulating HH 211 through 3D hydrodynamic jet propagation simulations using the PLUTO code with a molecular chemistry and cooling module, and initial conditions based on an analytical model derived from SMA observations. Our results show the reflection-symmetric wiggle can be recreated through the assumption of a jet source perturbed by binary motion at its base, and that a regular sinusoidal velocity variation in the jet beam can be close to matching the observed knot pattern. However, a more complex model with either additional heating from the protostar, or a shorter period velocity pulsation may be required to account for...

  16. Structure, strain, and composition profiling of InAs/GaAs(211)B quantum dot superlattices

    Florini, N.; Dimitrakopulos, G. P.; Kioseoglou, J.; Kehagias, Th., E-mail: kehagias@auth.gr [Physics Department, Aristotle University of Thessaloniki, 54624 Thessaloniki (Greece); Germanis, S.; Pelekanos, N. T. [Department of Materials Science and Technology, University of Crete, P.O. Box 2208, 70013 Heraklion (Greece); Microelectronics Research Group, IESL-FORTH, P.O. Box 1385, 71110 Heraklion (Greece); Katsidis, C. [Department of Materials Science and Technology, University of Crete, P.O. Box 2208, 70013 Heraklion (Greece); Hatzopoulos, Z. [Microelectronics Research Group, IESL-FORTH, P.O. Box 1385, 71110 Heraklion (Greece); Department of Physics, University of Crete, P.O. Box 2208, 70013 Heraklion (Greece)

    2016-01-21

    The morphology, nanostructure, and strain properties of InAs quantum dots (QDs) grown on GaAs(211)B, uncapped or buried, are explored by transmission electron microscopy and related quantitative techniques. Besides the built-in piezoelectric field, other differences of (211) growth compared to (100)-oriented growth are discussed in terms of the (211) surface non-singularity, leading to anisotropic shape of the QDs and local chemical inhomogeneity of the wetting layer. The shape of the uncapped QDs was precisely defined as truncated pyramidal, elongated along the 〈111〉 direction, and bounded by the (110), (100), and (213) facets. Local strain measurements showed that large surface QDs were almost unstrained due to plastic relaxation, exhibiting small residual elastic strain at the interface that gradually diminished toward their apex. Conversely, buried QDs were pseudomorphically grown on GaAs. By postulating a plane stress state, we have established a systematic increase of the local strain from the base toward the apex region of the QDs. Using Vegard's law, their chemical composition profiles were calculated, revealing an indium content gradient along the growth direction and compositional variants among different QDs. Photoluminescence measurements showed variations in emission energy between the QDs and consistency with a graded In-content, which complied with the quantitative strain analysis.

  17. DISCOVERY OF A NEW TeV GAMMA-RAY SOURCE: VER J0521+211

    Archambault, S. [Physics Department, McGill University, Montreal, QC H3A 2T8 (Canada); Arlen, T.; Aune, T. [Department of Physics and Astronomy, University of California, Los Angeles, CA 90095 (United States); Behera, B.; Federici, S. [DESY, Platanenallee 6, D-15738 Zeuthen (Germany); Beilicke, M.; Buckley, J. H.; Bugaev, V. [Department of Physics, Washington University, St. Louis, MO 63130 (United States); Benbow, W. [Fred Lawrence Whipple Observatory, Harvard-Smithsonian Center for Astrophysics, Amado, AZ 85645 (United States); Bird, R. [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland); Bouvier, A. [Santa Cruz Institute for Particle Physics and Department of Physics, University of California, Santa Cruz, CA 95064 (United States); Byrum, K. [Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL 60439 (United States); Cesarini, A.; Connolly, M. P. [School of Physics, National University of Ireland Galway, University Road, Galway (Ireland); Ciupik, L. [Astronomy Department, Adler Planetarium and Astronomy Museum, Chicago, IL 60605 (United States); Cui, W.; Feng, Q.; Finley, J. P. [Department of Physics, Purdue University, West Lafayette, IN 47907 (United States); Errando, M. [Department of Physics and Astronomy, Barnard College, Columbia University, NY 10027 (United States); Falcone, A., E-mail: fortin@veritas.sao.arizona.edu, E-mail: errando@astro.columbia.edu, E-mail: jholder@physics.udel.edu, E-mail: sfegan@llr.in2p3.fr [Department of Astronomy and Astrophysics, 525 Davey Lab, Pennsylvania State University, University Park, PA 16802 (United States); Collaboration: VERITAS Collaboration; and others

    2013-10-20

    We report the detection of a new TeV gamma-ray source, VER J0521+211, based on observations made with the VERITAS imaging atmospheric Cherenkov Telescope Array. These observations were motivated by the discovery of a cluster of >30 GeV photons in the first year of Fermi Large Area Telescope observations. VER J0521+211 is relatively bright at TeV energies, with a mean photon flux of (1.93 ± 0.13{sub stat} ± 0.78{sub sys}) × 10{sup –11} cm{sup –2} s{sup –1} above 0.2 TeV during the period of the VERITAS observations. The source is strongly variable on a daily timescale across all wavebands, from optical to TeV, with a peak flux corresponding to ∼0.3 times the steady Crab Nebula flux at TeV energies. Follow-up observations in the optical and X-ray bands classify the newly discovered TeV source as a BL Lac-type blazar with uncertain redshift, although recent measurements suggest z = 0.108. VER J0521+211 exhibits all the defining properties of blazars in radio, optical, X-ray, and gamma-ray wavelengths.

  18. Structure, strain, and composition profiling of InAs/GaAs(211)B quantum dot superlattices

    The morphology, nanostructure, and strain properties of InAs quantum dots (QDs) grown on GaAs(211)B, uncapped or buried, are explored by transmission electron microscopy and related quantitative techniques. Besides the built-in piezoelectric field, other differences of (211) growth compared to (100)-oriented growth are discussed in terms of the (211) surface non-singularity, leading to anisotropic shape of the QDs and local chemical inhomogeneity of the wetting layer. The shape of the uncapped QDs was precisely defined as truncated pyramidal, elongated along the 〈111〉 direction, and bounded by the (110), (100), and (213) facets. Local strain measurements showed that large surface QDs were almost unstrained due to plastic relaxation, exhibiting small residual elastic strain at the interface that gradually diminished toward their apex. Conversely, buried QDs were pseudomorphically grown on GaAs. By postulating a plane stress state, we have established a systematic increase of the local strain from the base toward the apex region of the QDs. Using Vegard's law, their chemical composition profiles were calculated, revealing an indium content gradient along the growth direction and compositional variants among different QDs. Photoluminescence measurements showed variations in emission energy between the QDs and consistency with a graded In-content, which complied with the quantitative strain analysis

  19. DISCOVERY OF A NEW TeV GAMMA-RAY SOURCE: VER J0521+211

    We report the detection of a new TeV gamma-ray source, VER J0521+211, based on observations made with the VERITAS imaging atmospheric Cherenkov Telescope Array. These observations were motivated by the discovery of a cluster of >30 GeV photons in the first year of Fermi Large Area Telescope observations. VER J0521+211 is relatively bright at TeV energies, with a mean photon flux of (1.93 ± 0.13stat ± 0.78sys) × 10–11 cm–2 s–1 above 0.2 TeV during the period of the VERITAS observations. The source is strongly variable on a daily timescale across all wavebands, from optical to TeV, with a peak flux corresponding to ∼0.3 times the steady Crab Nebula flux at TeV energies. Follow-up observations in the optical and X-ray bands classify the newly discovered TeV source as a BL Lac-type blazar with uncertain redshift, although recent measurements suggest z = 0.108. VER J0521+211 exhibits all the defining properties of blazars in radio, optical, X-ray, and gamma-ray wavelengths

  20. Discovery of a new TeV gamma-ray source: VER J0521+211

    Archambault, S; Aune, T; Beilicke, M; Benbow, W; Bird, R; Bouvier, A; Buckley, J H; Bugaev, V; Byrum, K; Cesarini, A; Ciupik, L; Connolly, M P; Cui, W; Errando, M; Falcone, A; Federici, S; Feng, Q; Finley, J P; Fortson, L; Furniss, A; Galante, N; Gall, D; Gillanders, G H; Griffin, S; Grube, J; Gyuk, G; Hanna, D; Holder, J; Hughes, G; Humensky, T B; Kaaret, P; Kertzman, M; Khassen, Y; Kieda, D; Krawczynski, H; Krennrich, F; Kumar, S; Lang, M J; Madhavan, A S; Maier, G; Majumdar, P; McArthur, S; McCann, A; Millis, J; Moriarty, P; Mukherjee, R; de Bhroithe, A O'Faolain; Ong, R A; Otte, A N; Park, N; Perkins, J S; Pohl, M; Popkow, A; Prokoph, H; Quinn, J; Ragan, K; Reyes, L C; Reynolds, P T; Richards, G T; Roache, E; Saxon, D B; Sembroski, G H; Smith, A W; Staszak, D; Telezhinsky, I; Theiling, M; Varlotta, A; Vassiliev, V V; Vincent, S; Wakely, S P; Weekes, T C; Weinstein, A; Welsing, R; Williams, D A; Zitzer, B; Bottcher, M; Fegan, S J; Fortin, P; Halpern, J P; Kovalev, Y Y; Lister, M L; Liu, J; Pushkarev, A B; Smith, P S

    2013-01-01

    We report the detection of a new TeV gamma-ray source, VER J0521+211, based on observations made with the VERITAS imaging atmospheric Cherenkov telescope array. These observations were motivated by the discovery of a cluster of >30GeV photons in the first year of Fermi-LAT observations. VER J0521+211 is relatively bright at TeV energies, with a mean photon flux of 1.93 +/- 0.13_stat +/- 0.78_sys 10^-11 cm-2 s-1 above 0.2 TeV during the period of the VERITAS observations. The source is strongly variable on a daily timescale across all wavebands, from optical to TeV, with a peak flux corresponding to ~0.3 times the steady Crab Nebula flux at TeV energies. Follow-up observations in the optical and X-ray bands classify the newly-discovered TeV source as a BL Lac-type blazar with uncertain redshift, although recent measurements suggest z=0.108. VER J0521+211 exhibits all the defining properties of blazars in radio, optical, X-ray, and gamma-ray wavelengths.

  1. Project W-211, initial tank retrieval systems, retrieval control system software configuration management plan

    This Software Configuration Management Plan (SCMP) provides the instructions for change control of the W-211 Project, Retrieval Control System (RCS) software after initial approval/release but prior to the transfer of custody to the waste tank operations contractor. This plan applies to the W-211 system software developed by the project, consisting of the computer human-machine interface (HMI) and programmable logic controller (PLC) software source and executable code, for production use by the waste tank operations contractor. The plan encompasses that portion of the W-211 RCS software represented on project-specific AUTOCAD drawings that are released as part of the C1 definitive design package (these drawings are identified on the drawing list associated with each C-1 package), and the associated software code. Implementation of the plan is required for formal acceptance testing and production release. The software configuration management plan does not apply to reports and data generated by the software except where specifically identified. Control of information produced by the software once it has been transferred for operation is the responsibility of the receiving organization

  2. microRNA in situ hybridization for miR-211 detection as an ancillary test in melanoma diagnosis.

    Babapoor, Sankhiros; Horwich, Michael; Wu, Rong; Levinson, Shauna; Gandhi, Manoj; Makkar, Hanspaul; Kristjansson, Arni; Chang, Mary; Dadras, Soheil S

    2016-05-01

    Some melanocytic tumors can be histologically ambiguous causing diagnostic difficulty, which could lead to overtreatment of benign lesions with an unwarranted psychological distress or undertreatment of malignant cancers. Previously, we demonstrated that significantly decreased miR-211 expression in melanomas compared with melanocytic nevi could accurately discriminate malignant from benign tumors. Herein we show microRNA in situ hybridization for fluorescent detection of miR-211, suitable for paraffin-embedded tissues in 109 primary melanocytic tumors. miR-211 expression was significantly lower in melanomas vs nevi (Pnuclear atypia. All 35 melanocytic tumors with Spitz morphology expressed miR-211 independent of morphological classification, where clinical follow-up of these patients showed no recurrence at the site or metastasis in mean and median of 3 (ranging 2-5) years. Moreover, a decision tree learning analysis selected age and miR-211 miRNA in situ hybridization as the predictive variables for benign or malignant outcome in 88 patients correctly classified 92% (81 out of 88) of cases as proven by receiver operating characteristic curve (area under the curve=0.9029). These results support miR-211 as a leading miRNA candidate for melanoma diagnosis and miRNA in situ hybridization as a uniquely uncomplicated ancillary test. PMID:26916074

  3. DNA damage in lymphocytes after irradiation with 211At and 188Re. Quantification by alkaline and neutral comet assay

    Aim: Ionising radiation produces many types of DNA lesions of different complexity. High linear energy transfer (LET) types of radiation are biological more effective than low LET radiation. In the present work we applied the single cell gel electrophoreses (comet assay) to study the induction of initial DNA damage, efficiency of repair and residual DNA damage in lymphocytes after treatment with 211At and 188Re. Methods: Peripheral blood mononuclear cells (PBMC) were isolated from heparinized blood of healthy donors and irradiated with 211At and 188Re at different doses. The comet assay was performed under alkaline and neutral conditions in order to detect the initial DNA damage and its repair. The measure of damage was% tail DNA (percentage of DNA in the tail). Results: After treatment of cells with 188Re the initial DNA damage (% tail DNA) detected with the alkaline comet assay was higher than the damage measured for 21lAt. The neutral comet assay estimated higher tail intensities for 211At in contrast to 188Re. Compared with the complete repair (10%) after irradiation with 188Re, the radiotoxicity of alpha particles indicated reduced rejoining of DNA strand breaks (60-80% residual damage). Rejoining of DNA damage measured by the neutral comet method detected about 70% unrepaired strand breaks for 211At and 188Re. Conclusions: There are major differences between the repair of strand breaks caused by 188Re and 211At detected by the alkaline comet assay. The DNA-damage induced by the high LET Emitter 211At remains nearly unrepaired detected by both alkaline and neutral comet assay. Represented data following irradiation of lymphocytes with alpha and beta particles demonstrated higher biological effectiveness of 211At by factors of 2.0-2.5. (orig.)

  4. Detection of serum CYFRA21-1 in patients with urothelial bladder carci-noma%膀胱尿路上皮细胞癌患者血清 CYFRA21-1水平的测定

    孔朝辉; 朱晓博; 范小玲

    2014-01-01

    目的:检测膀胱尿路上皮细胞癌患者血清中CYFRA21-1水平并探讨其临床意义。方法:采用电化学发光免疫分析技术检测57例膀胱尿路上皮细胞癌患者和52例泌尿系统良性疾病患者以及49例健康个体血清CY-FRA21-1水平。结果:膀胱尿路上皮细胞癌患者血清CYFRA21-1水平和阳性率均高于泌尿系统良性疾病患者与健康人群( F/χ2=28.949、15.221,P均<0.05)。膀胱尿路上皮细胞癌病理分级与血清CYFRA21-1水平及阳性率均无关(P均>0.05)。 T3及T3M+期肿瘤较Ta、T1、T2期肿瘤患者血清CYFRA21-1水平及阳性率均升高(F/χ2=2.096、34.232,P均<0.05);与初发肿瘤相比,复发膀胱尿路上皮细胞癌患者血清CYFRA21-1水平及阳性率均升高(t/χ2=3.968、9.541,P均<0.05)。结论:血清CYFRA21-1可以作为膀胱尿路上皮细胞癌的一个可靠的肿瘤标志物,特别是在监测膀胱尿路上皮癌转移或复发时更具优势。%Aim:To study value of serum CYFRA21-1 in urothelial bladder carcinoma and its clinical significance . Methods:Electrochemiluminescence method was used to detect serum CYFRA 21-1 level of 158 patients, including 57 ca-ses with urothelial bladder carcinoma (group 1), 52 cases with benign diseases of the urinary system (group 2), and 49 healthy individuals(group 3).Results: Compared with group 2 and group 3, serum CYFRA21-1 level and positive rate were significantly higher in group 1 (F/χ2 =28.949,15.221,P0.05).The CYFRA21-1 level and positive rate increased significantly in T 3 and T3M+stage compared to Ta, T1 and T2 stage(F/χ2 =2.096,34.232,P<0.05).Compared with primary tumor, serum CYFRA21-1 level and positive rate were significantly increased in recurrent urothelial bladder carcinoma ( t/χ2 =3.968, 9.541,P<0.05).Conclusion:Serum CYFRA21-1 seems to be a marker of urothelial bladder carcinoma .It is useful for monitoring this disease

  5. Preliminary study on guiding therapy of subcutaneous human hetero graft in nude mice by 211-At labelled monoclonal antibody against gastric cancer

    In short time, 211At labelled monoclonal antibody 3H11 inhibited the growth of human gastric cancer grafted in nude mice effectively. The most evident inhibition was observed at the 9th day after treatment, and the tumor inhibition rates were 80%, 93%, 48% in the groups of intravenous injection, internal tumor injection (both 211At-3H11 5 μCi per animal), Na211 At (5 μCi per animal) treatment respectively. On the 20th day, when animals were killed, the tumor inhibition rates were 66%, 81%, 6%, respectively. Inhibition treated with Na211At showed obviously lower than those at the 9th day

  6. Diagnostic utility of pleural fluid carcinoembryonic antigen and CYFRA 21-1 in patients with pleural effusion: A systematic review and meta-analysis

    Full text: Objective: To assess and compare the overall value of pleural fluid CEA and CYFRA 21-1 in differential diagnosis of pleural effusions with a meta-analysis. Methods: All the English and Chinese published studies for differential diagnosis of pleural effusions by pleural fluid CEA and CYFRA 21-1 were collected. Methodological quality of the included studies was then evaluated. Pooled sensitivity and specificity were calculated, the threshold effect and the possible sources of heterogeneity were also analyzed. SROC (summary receiver operating characteristic) was used to compare the differential diagnostic ability of pleural fluid CEA and CYFRA 21-1. Results: 19 studies were included in the meta-analysis, with a total of 3228 subjects. Pooled sensitivity and specificity of CEA and CYFRA 21-1 were 45.9%(43.2%- 48.5%),97.0%(96.0%-97.8%) and 47.3%(44.0%- 50.6%),91.8%(89.5%-93.7), respectively. Both CEA and CYFRA 21-1 have a threshold effect, the main source of heterogeneity was from variable assay methods. AUC (area under the curve) of CEA and CYFRA 21-1 were 0.7691 and 0.8213, respectively. There was no statistical significance between the AUC of CEA and CYFRA 21-1 (p>0.05). Conclusion: Both CEA and CYFRA 21-1 have good performance at differential diagnosis of pleural effusion, while compared with CEA, CYFRA 21-1 has no advantage. (author)

  7. 211At production and recovery: first results of a new start

    Full text: 211At is the only alpha-emitting isotope which can be introduced into organic molecular structures by covalent chemical binding and possesses superior decay characteristics for therapeutic applications when compared with other alpha emitters. However, its production requires a minimum of 27,5 MeV alpha-particles, which are relatively rarely available. In view of the revival of alpha-therapy approaches a production of 211At has been set up at the MHH cyclotron (MC-35). The first aim of this project was to establish a target- and work-up-system for the reliable production of several ten MBq-quantities of 211At for animal- and cell-research. An aluminum-target-system holds a 1.3 cm diameter Bi-disc of 0.25 mm thickness. The disk is pressed onto a the aluminum backing with 2 tons/cm2. The front is covered with a 125 μm Al foil, cooled by a He jet which is separated from the vacuum by a 250 μm Ti foil. Starting with 27.5 MeV alpha-particles the resulting target-energy is 25 MeV. This relatively low energy is chosen to avoid any contamination with 210At and 210Po in the first experimental period. A beam current of 10 μA for 15 min (9 mCoulomb) yields 16.4 MBq 211At theoretically. Astatine is recovered from the target by a dry distillation technique, using various gases as a transport support-medium. The small all-quartz distillation-apparatus is heated up to 900 oC. Astatine is recovered in a small cool able vessel containing various trapping media. Distillation and trapping can be monitored with small radioactivity monitors. The whole system fits in a cubical 0.5 m glove box. Continuous monitoring of the distillation process allowed to optimize the heating rate, the transport support-medium and its flow-rate. Various trapping solutions were tested for their efficiency. Different beam dispersion in the target seems to influence the release and distillation of astatine from the molten bismuth-target. Two different release patterns were observed. The first

  8. Environmental Assessment for the Independent Waste Handling Facility, 211-F at the Savannah River Site

    Currently, liquid Low Activity Waste (LAW) and liquid High Activity Waste (HAW) are generated from various process operational facilities/processes throughout the Savannah River Site (SRS) as depicted on Figure 2-1. Prior to storage in the F-Area tank farm, these wastes are neutralized and concentrated to minimize their volume. The Waste Handling Facility (211-3F) at Building 211-F Complex (see Figure 2-2) is the only existing facility onsite equipped to receive acidic HAW for neutralization and volume reduction processing. Currently, Building 221-F Canyon (see Figure 2-2) houses the neutralization and evaporation facilities for HAW volume reduction and provides support services such as electric power and plant, process, and instrument air, waste transfer capabilities, etc., for 21 1-F operations. The future plan is to deactivate the 221-F building. DOE's purpose is to be able to process the LAW/HAW that will continue to be generated on site. DOE needs to establish an alternative liquid waste receipt and treatment capability to support site facilities with a continuing mission. The desire is for Building 211-F to provide the receipt and neutralization functions for LAW and HAW independent of 221-F Canyon. The neutralization capability is required to be part of the Nuclear Materials Stabilization Programs (NMSP) facilities since the liquid waste generated by the various site facilities is acidic. Tn order for Waste Management to receive the waste streams, the solutions must be neutralized to meet Waste Management's acceptance criteria. The Waste Management system is caustic in nature to prevent corrosion and the subsequent potential failure of tanks and associated piping and hardware

  9. Noninvasive measurement of liver regeneration with positron emission tomography and [2-11C]thymidine

    The feasibility of liver regeneration determination with [2-11C]thymidine and positron emission tomography was investigated in partially hepatectomized rats. Serial tomographic scans were performed over a 120-minute period after injection of [2-11C]thymidine together with tritium-labeled thymidine. Within 10 minutes after injection, positron emission tomography scans showed a twofold higher hepatic uptake in regenerating than in nonregenerating livers. Time-activity curves over the liver area indicated that the maximal uptake was followed by a faster decrease of 11C radioactivity in controls than in regenerating animals, so that total 11C activity remaining in the liver at 120 minutes accounted for 68% of maximum in regenerating and only 38% in controls. Tissue distribution studies performed at 120 minutes showed that total 11C radioactivity, expressed in percent injected dose per gram, was six times higher in regenerating livers than in controls (0.62% ± 0.07% in regenerating livers and 0.10% ± 0.03% in nonregenerating livers; P less than 0.001) and correlated with 3H radioactivity measured in the nuclear fraction (r = 0.92; P less than 0.001). When the hepatic uptake was expressed in percent of dose per organ, the difference between both groups increased (2.31% ± 0.23% in regenerating livers and 0.29% ± 0.02% in nonregenerating livers; P less than 0.001) because of higher weight of regenerating livers than of nonregenerating livers (3.83 ± 0.11 g in regenerating livers and 2.96 ± 0.16 g in nonregenerating livers; P less than 0.001). In other organs examined, no difference in 11C radioactivity was found between the two groups of rats. These results indicated the potential usefulness of [2-11C]thymidine and positron emission tomography for noninvasive measurement of liver regeneration

  10. Labelling prospects of astatine-211 with immunoglobulins (IgG): some general considerations

    The tumour therapeutic potential of the short lived alpha emitting radiohalogen 211At has been already been well recognised in the field of radioimmuno therapy. There is no evidence as such to show that astatine itself is a tumour seeking isotope. Therefore it has to be tagged to tumour seeking compound such as a drug or a protein preferably an antibody (IgG). In this communication, the labelling parameters which are required to be investigated for obtaining a stable product which could be useful as radioimmuno therapeutic agent, are described. (author). 6 refs

  11. B Plant canyon sample TK-21-1 analytical results for the final report

    Steen, F.H.

    1998-04-10

    This document is the analytical laboratory report for the TK-21-1 sample collected from the B Plant Canyon on February 18, 1998. The sample was analyzed in accordance with the Sampling and Analysis Plan for B Plant Solutions (SAP) (Simmons, 1997) in support of the B Plant decommissioning project. Samples were analyzed to provide data both to describe the material which would remain in the tanks after the B Plant transition is complete and to determine Tank Farm compatibility. The analytical results are included in the data summary table (Table 1).

  12. B Plant canyon sample TK-21-1 analytical results for the final report

    This document is the analytical laboratory report for the TK-21-1 sample collected from the B Plant Canyon on February 18, 1998. The sample was analyzed in accordance with the Sampling and Analysis Plan for B Plant Solutions (SAP) (Simmons, 1997) in support of the B Plant decommissioning project. Samples were analyzed to provide data both to describe the material which would remain in the tanks after the B Plant transition is complete and to determine Tank Farm compatibility. The analytical results are included in the data summary table (Table 1)

  13. Low lying baryon spectrum with N{sub f}=2+1+1 dynamical twisted quarks

    Drach, Vincent; Jansen, Karl [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Carbonell, Jaume; Papinutto, Mauro [UJF, CNRS/IN2P3, INPG (France). Lab. de Physique Subatomique et de Cosmologie; Alexandrou, Constantia [Cyprus Univ., Nicosia (Cyprus). Dept. of Physics

    2010-12-15

    We present first results on the octet and decuplet strange baryon spectrum with N{sub f}=2+1+1 twisted mass quarks. We use an Osterwalder Seiler valence strange quark with a mass tuned to the kaon and compare the results with those obtained in the unitary setup. This comparison allows to perform a first study of the lattice artefacts introduced by the mixed action approach. We investigate the effect of the strange and charm quarks in the sea by using two lattice spacings and comparing with preceding N{sub f}=2 twisted mass fermion calculations. (orig.)

  14. Status of ETMC simulations with Nf=2+1+1 twisted mass fermions

    Baron, R; Deuzeman, A; Drach, V; Farchioni, F; Giménez, V; Herdoiza, G; Jansen, K; Montvay, I; Palao, D; Pallante, E; Pène, O; Reker, S; Scholz, E E; Urbach, C; Wagner, M; Wenger, U

    2008-01-01

    We present the status of runs performed in the twisted mass formalism with $N_{\\rm f}=2+1+1$ flavours of dynamical fermions: a degenerate light doublet and a mass split heavy doublet. The procedure for tuning to maximal twist will be described as well as the current status of the runs using both thin and stout links. Preliminary results for a few observables obtained on ensembles at maximal twist will be given. Finally, a reweighting procedure to tune to maximal twist will be described.

  15. Light hadrons from Nf=2+1+1 dynamical twisted mass fermions

    Baron, R; Boucaud, P; Carbonell, J; Deuzeman, A; Drach, V; Farchioni, F; Gimenez, V; Herdoiza, G; Jansen, K; Michael, C; Montvay, I; Pallante, E; Pène, O; Reker, S; Urbach, C; Wagner, M; Wenger, U

    2010-01-01

    We present results of lattice QCD simulations with mass-degenerate up and down and mass-split strange and charm (Nf=2+1+1) dynamical quarks using Wilson twisted mass fermions at maximal twist. The tuning of the strange and charm quark masses is performed at three values of the lattice spacing a~0.06 fm, a~0.08 fm and a~0.09 fm with lattice sizes ranging from L~1.9 fm to L~3.9 fm. We perform a preliminary study of SU(2) chiral perturbation theory by combining our lattice data from these three values of the lattice spacing.

  16. Low lying baryon spectrum with Nf=2+1+1 dynamical twisted quarks

    We present first results on the octet and decuplet strange baryon spectrum with Nf=2+1+1 twisted mass quarks. We use an Osterwalder Seiler valence strange quark with a mass tuned to the kaon and compare the results with those obtained in the unitary setup. This comparison allows to perform a first study of the lattice artefacts introduced by the mixed action approach. We investigate the effect of the strange and charm quarks in the sea by using two lattice spacings and comparing with preceding Nf=2 twisted mass fermion calculations. (orig.)

  17. Detection of extragalactic CF+ toward PKS1830-211 -- Chemical differentiation in the absorbing gas

    Muller, S; Black, J H; Amano, T

    2016-01-01

    We report the first extragalactic detection of CF+, the fluoromethylidynium ion, in the z=0.89 absorber toward PKS1830-211. We estimate an abundance of ~3E-10 relative to H2 and that ~1% of fluorine is captured in CF+. The absorption line profile of CF+ is found to be markedly different from that of other species observed within the same tuning, and is notably anti-correlated with CH3OH. On the other hand, the CF+ profile resembles that of [C I]. Our results are consistent with expected fluorine chemistry and point to chemical differentiation in the column of absorbing gas.

  18. Project W-211 Initial Tank Retrieval Systems (ITRS) Description of Operations for 241-AZ-102

    The primary purpose of the Initial Tank Retrieval Systems (ITRS) is to provide systems for retrieval of radioactive wastes stored in underground double-shell tanks (DSTs) for transfer to alternate storage, evaporation, pretreatment or treatment, while concurrently reducing risks associated with safety watch list and other DSTs. This Description of Operation (DOO) defines the control philosophy for the waste retrieval system for Tank 241-AZ-102 (AZ-102). This DOO provides a basis for the detailed design of the Project W-211 Retrieval Control System (RCS) for AZ-102 and also establishes test criteria for the RCS

  19. Update on the 2+1+1 flavor QCD equation of state with HISQ

    Bazavov, A; DeTar, C; Foley, J; Gottlieb, Steven; Heller, U M; Hetrick, J E; Laiho, J; Levkova, L; Osborn, J; Sugar, R; Toussaint, D; Van de Water, R S; Zhou, R

    2013-01-01

    We present recent results on the QCD equation of state with 2+1+1 flavors of highly improved staggered quarks (HISQ). We focus on three sets of ensembles with temporal extent 6, 8 and 10, that reach up to temperatures of 967, 725 and 580 MeV, respectively. The strange and charm quark masses are tuned to the physical values and the light quarks mass is set to one fifth of the strange. This corresponds to a Goldstone pion of about 300 MeV.

  20. Nucleon matrix elements with $N_f=2+1+1$ maximally twisted fermions

    Dinter, Simon; Constantinou, Martha; Drach, Vincent; Jansen, Karl; Renner, Dru

    2010-01-01

    We present the first lattice calculation of nucleon matrix elements using four dynamical flavors. We use the $N_f=2+1+1$ maximally twisted mass formulation. The renormalization is performed non-perturbatively in the RI$^\\prime$-MOM scheme and results are given for the vector and axial vector operators with up to one-derivative. Our calculation of the average momentum of the unpolarized non-singlet parton distribution is presented and compared to our previous results obtained from the $N_f=2$ case.

  1. Spectroscopy of high spin states in sup(211,212,213)Fr

    The level structures of 211Fr, 212Fr and 213Fr have been observed to high spins, approx. 28(h/2π) (and excitation energies approx. 8 MeV) using a variety of gamma-ray spectroscopic techniques. The structure of these nuclides is discussed in terms of couplings of single particle states through empirical shell model calculations. Good agreement with experiment is obtained. In 212Fr and 213Fr core-excited configurations are required to explain the properties of the highest states. A number of long lived states were observed in each nucleus some of which decay by by enhanced E3 transitions. The E3 transition strengths are discussed

  2. Monitoring of therapy in head and neck patients during the radiotherapy by measurement of Cyfra 21-1; Le Cyfra 21-1 est-il un bon marqueur dans le suivi de patients atteints de cancer ORL?

    Pradier, O.; Hille, A.; Schmiberger, H.; Hess, C.F. [Gottingen Universitat, Dept. of Radiotherapy, (Germany)

    2002-02-01

    Purpose. - Cyfra 21-1, measuring serum fragments of cyto-keratin 19, has been found to be related to tumour stage and tumour size in patients with cervical cancer. It could be a promising marker in squamous lung cancer. We evaluated this new marker with carcinoembryonic antigen, (CEA) and squamous cell carcinoma antigen (SCC-Ag) in the monitoring of 27 patients with head and neck cancer. Patients and methods. -The retrospective study group consisted of 27 patients, 17 not suited for surgery and 10 after laser resection. Patients were clinically staged according to the TNM-classification. The mean age of the patients was 53 years (range 37-70 years). Serum levels of each marker were studied in relation to tumour stage and clinical status of the patients during radiotherapy and 6 weeks after the end of the treatment. The clinical performance of the various assays to separate those patients with complete remission from those patients with the presence of tumour was assessed. Results. - Pre-treatment serum Cyfra 21-1, CEA, and SCC-Ag levels were not related to stage of disease and were not found to be predictive of tumour response. The clinical performance of post-treatment serum SCC-Ag levels in predicting the presence of tumour was not better than the Cyfra 21-1 assays. Conclusion. - We could not conclude from this study that Cyfra 21-1 marker is an additional parameter in identifying patients at risk of residual tumour after treatment, recurrent or progressive disease. An elevation of Cyfra 21-1 marker was not detectable in 70% of the cases with macroscopic tumour. Therefore, Cyfra 21-1 is not a reliable parameter for the monitoring of patients with head and.neck cancer during radiotherapy. (authors)

  3. Treatment of HER2-positive breast carcinomatous meningitis with intrathecal administration of α-particle-emitting 211At-labeled trastuzumab

    Introduction: Carcinomatous meningitis (CM) is a devastating disease characterized by the dissemination of malignant tumor cells into the subarachnoid space along the brain and spine. Systemic treatment with monoclonal antibody (mAb) trastuzumab can be effective against HER2-positive systemic breast carcinoma but, like other therapies, is ineffective against CM. The goal of this study was to evaluate the therapeutic effect of α-particle emitting 211At-labeled trastuzumab following intrathecal administration in a rat model of breast carcinoma CM. Methods: Athymic rats were injected intrathecally with MCF-7/HER2-18 breast carcinoma cells through a surgically implanted indwelling intrathecal catheter. In Experiment 1, animals received 33 or 66 μCi 211At-labeled trastuzumab, cold trastuzumab or saline. In Experiment 2, animals were inoculated with a lower tumor burden and received 46 or 92 μCi 211At-labeled trastuzumab or saline. In Experiment 3, animals received 28 μCi 211At-labeled trastuzumab, 30 μCi 211At-labeled TPS3.2 control mAb or saline. Histopathological analysis of the neuroaxis was performed at the end of the study. Results: In Experiment 1, median survival increased from 21 days for the saline and cold trastuzumab groups to 45 and 48 days for 33 and 66 μCi 211At-labeled trastuzumab, respectively. In Experiment 2, median survival increased from 23 days for saline controls to 68 and 92 days for 46 and 92 μCi 211At-labeled trastuzumab, respectively. In Experiment 3, median survival increased from 20 days to 29 and 36 days for animals treated with 211At-labeled TPS3.2 and 211At-labeled trastuzumab, respectively. Long-term survivors were observed exclusively in the 211At-trastuzumab-treated groups. Conclusion: Intrathecal 211At-labeled trastuzumab shows promise as a treatment for patients with HER2-positive breast CM.

  4. MiR-211 is epigenetically regulated by DNMT1 mediated methylation and inhibits EMT of melanoma cells by targeting RAB22A.

    Yu, Haizhou; Yang, Weixi

    2016-08-01

    MiR-211 has strong inhibitive effects on melanoma cell growth, invasion and metastasis. However, how it is downregulated and whether other genes are involved its downstream regulation in melanoma are not clear. In this study, we firstly verified the expression of miR-211 in melanoma cell lines and observed that its downregulation is associated with increased DNMT1 expression. By performing qRT-PCR and MSP analysis, we confirmed that DNMT1 is negatively correlated with miR-211 expression and can modulate DNA methylation in the promoter region of miR-211. By performing bioinformatics analysis, we found that RAB22A is a possible target of miR-211, which has two broadly conversed binding sites with miR-211 in the 3'UTR. Following dual luciferase assay, qRT-PCR and western blot analysis confirmed the direct binding between miR-211 and RAB22A and the suppressive effect of miR-211 on RAB22A expression. Knockdown of RAB22A increased epithelial properties and impaired mesenchymal properties of the melanoma cells, suggesting that miR-211 modulates epithelial mesenchymal transition (EMT) of melanoma cells via downregulating RAB22A. In summary, the present study firstly demonstrated that DNMT1 mediated promoter methylation is a mechanism of miRNA suppression in melanoma and revealed a new tumor suppressor role of the miR-211 by targeting RAB22A in melanoma. The DNMT1/miR-211/RAB22A axis provides a novel insight into the pathogenesis of melanoma, particularly in the EMT process. PMID:27237979

  5. Radiopharmaceutical for differential diagnosis of tuberculoma: synthesis of 2-[11C]cyano-isonicotinic acid hydrazide

    The radiochemical synthesis of 2-[11C]cyano-isonicotinic acid hydrazide was accomplished. Carbon-11 labelled cyano-group was introduced at the 2-position of the pyridine ring of 1-methoxy-4-methoxycarbonyl pyridinium methyl sulfate via a Riessert-Kaufmann type reaction. The reaction was performed on a solid support (silica gel) to yield no-carrier-added methyl 2-[11C]cyano-isonicotinate in (32.4 ± 12%) (EOB) yield. This method is unique for the incorporation of [11C]HCN to base sensitive substrates. The carbon-11 labelled methyl ester was treated with hydrazine hydrate to obtain 2-[11C]cyano-isonicotinic acid hydrazide. The final radiochemical yield was 10% (EOB) and the synthesis time was approximately 35 min. (author)

  6. Animal experiments on pigs using human serum albumin microspheres labelled with 211At regarding the introduction of endoarterial therapy

    211At-humanserumalbumin microspheres are presented as a potential radiopharmaceutical for alpha-endotherapy of malignant tumors. In vivo studies in animals (pigs) using a modification of the SELDINGER technique via the carotid arteria revealed an accumulation of the microspheres in selected areas of larynx and tongue. By variation of catheter position and flow rate the place of the highest radioactivity in the tongue according to the tumor localisation can be chosen. Scintigraphic estimation of biodistribution and kinetic of the 211At preparation and first autoradiographic studies of tongue tissue samples yielded an accumulation of 90% and a homogeneous distribution in the expected tongue region. Clinical follow-up and paraclinical observation (blood count, thyroid function) in the hitherto one year's study period did not show any 211At microspheres related adverse reactions. (orig.)

  7. Monitoring of therapy in head and neck patients during the radiotherapy by measurement of Cyfra 21-1

    Purpose. - Cyfra 21-1, measuring serum fragments of cyto-keratin 19, has been found to be related to tumour stage and tumour size in patients with cervical cancer. It could be a promising marker in squamous lung cancer. We evaluated this new marker with carcinoembryonic antigen, (CEA) and squamous cell carcinoma antigen (SCC-Ag) in the monitoring of 27 patients with head and neck cancer. Patients and methods. -The retrospective study group consisted of 27 patients, 17 not suited for surgery and 10 after laser resection. Patients were clinically staged according to the TNM-classification. The mean age of the patients was 53 years (range 37-70 years). Serum levels of each marker were studied in relation to tumour stage and clinical status of the patients during radiotherapy and 6 weeks after the end of the treatment. The clinical performance of the various assays to separate those patients with complete remission from those patients with the presence of tumour was assessed. Results. - Pre-treatment serum Cyfra 21-1, CEA, and SCC-Ag levels were not related to stage of disease and were not found to be predictive of tumour response. The clinical performance of post-treatment serum SCC-Ag levels in predicting the presence of tumour was not better than the Cyfra 21-1 assays. Conclusion. - We could not conclude from this study that Cyfra 21-1 marker is an additional parameter in identifying patients at risk of residual tumour after treatment, recurrent or progressive disease. An elevation of Cyfra 21-1 marker was not detectable in 70% of the cases with macroscopic tumour. Therefore, Cyfra 21-1 is not a reliable parameter for the monitoring of patients with head and.neck cancer during radiotherapy. (authors)

  8. Serum tumor marker CYFRA 21-1 in the diagnostics of squamous cell lung cancer - comparison with CEA

    The aim of the study was to test the diagnostic value tumor marker CYFRA 21-1 for squamous cell lung cancer (SQCLC) in comparison with carcinoembryonic antigen (CEA). Ninety-one patients were induced in this study: 56 with SQCLC - Group I, 25 with other types of lung cancer - Group II, 10 with benign respiratory tract diseases - Group III. Median CYFRA 21-1 serum concentration (ng/ml) was: in Group I: 4.52 (0.94 - >16), in Group II: 3.58 (1.72 - >16), in Group III: 2.05 (0.99 - 3.41). Median CEA serum concentration (ng/ml) was: in Group I: 4.49 (076- >20), in Group II: 3.32 (1.17 - >20), in Group III: 3.09 (1.84 - 6.37). There was a highly significant difference between the levels of CYFRA 21-1 in group I and Group III (p < 0.001), but there was no statistically significant difference between the levels of CEA in Group I and III. Sensitivity of CYFRA 21-1 by the cut-off 3.33 ng/ml in the diagnostics of SQCLC was 0.68, specificity 0.090, positive predictive value 0.91, negative predictive value 0.65. Sensitivity of CEA by cut-off 4.61 ng/ml was 0.5 by the same specificity 0.90. CYFRA 21-1 has high sensitivity, specificity and positive predictive value in the diagnostics of SQCLC. Sensitivity of CYFRA 21-1 is significantly higher than sensitivity of CEA in this settings. (author)

  9. Fabrication of YBCO coated conductor by TFA-MOD using the '211 process'

    YBCO film was fabricated by the TFA-MOD method based on the '211 process' in which precursors of Y2Ba1Cu1O x (Y211) and Ba3Cu5O8 powders, instead of Y-, Ba-, and Cu-based acetates, were dissolved in trifluoroacetic acid (TFA) in order to explore its possible application in coated conductors. We evaluated the effects of the humidity and firing temperature on the phase formation, texture formability, and critical temperature (T c) and current (I c) of the YBCO film. We successively synthesized pure YBCO films of which those fired in 12.1-20.0% humidified Ar gas showed the highest critical properties, viz. a T c-zero of 88.6 K and I c of 30 A/cm width. These improvements in the critical properties were attributed to the formation of pure YBCO phase, to the improved density and the large grain size. In addition, we observed that the I c varied significantly with the firing temperature. The variation of the I c with the firing temperature was correlated with the microstructural evolution

  10. OH+ and H2O+ absorption toward PKS1830-211

    Muller, S; Black, J H; Beelen, A; Combes, F; Curran, S; Gerin, M; Guelin, M; Henkel, C; Martin, S; Aalto, S; Falgarone, E; Menten, K M; Schilke, P; Wiklind, T; Zwaan, M A

    2016-01-01

    We report the detection of OH+ and H2O+ in the z=0.89 absorber toward the lensed quasar PKS1830-211. The abundance ratio of OH+ and H2O+ is used to quantify the molecular hydrogen fraction (fH2) and the cosmic-ray ionization rate of atomic hydrogen (zH) along two lines of sight, located at ~2 kpc and ~4 kpc to either side of the absorber's center. The molecular fraction decreases outwards, from ~0.04 to ~0.02, comparable to values measured in the Milky Way at similar galactocentric radii. For zH, we find values of ~2x10^-14 s^-1 and ~3x10^-15 s^-1, respectively, which are slightly higher than in the Milky Way at comparable galactocentric radii, possibly due to a higher average star formation activity in the z=0.89 absorber. The ALMA observations of OH+, H2O+, and other hydrides toward PKS1830-211 reveal the multi-phase composition of the absorbing gas. Taking the column density ratios along the southwest and northeast lines of sight as a proxy of molecular fraction, we classify the species ArH+, OH+, H2Cl+, H...

  11. Synthesis of trapezohedral indium oxide nanoparticles with high-index {211} facets and high gas sensing activity.

    Han, Xiguang; Han, Xiao; Sun, Linqiang; Gao, Shengguang; Li, Liang; Kuang, Qin; Xie, Zhaoxiong; Wang, Chao

    2015-06-14

    Nanocrystals with high-index facets usually exhibit higher catalytic activities than those with only low-index facets. Trapezohedron-shaped (TS) In2O3 particles with exposed high-index {211} facets were successfully synthesized in an oleic acid (OA) and trioctylamine (TOA) system. It has been demonstrated that the gas sensing activity of TS In2O3 particles with exposed high-index {211} facets is higher than that of octahedron-shaped In2O3 particles with exposed low-index {111} facets. PMID:25930122

  12. Tumor marker CYFRA 21-1 in assessment of radiation treatment efficacy at local non-small-cell lung cancer

    The results of radiation therapy (RT) at various fractionation modes with Etopiside and Cysplatin modification in patients with non-small-cell lung cancer (NSCLC) are analyzed. The objective effect of accelerated RT was accompanied by statistically significant reduction of blood serum CYFRA 21-1 level (an index of proteolytic tumor degradation). It was established that the dynamics of blood serum CYFRA 21-1 expression coincided with the clinical findings and could be used for prognosis and monitoring of chemoradiation therapy efficacy in patients with NSCLC.

  13. CEA, CYFRA 21-1, NSE, and ProGRP in the diagnosis of lung cancer: a multivariate approach

    Gruber, Christine; Hatz, Rudolf; Reinmiedl, Judith; Nagel, Dorothea; Stieber, Petra

    2008-01-01

    We retrospectively studied the single and combined diagnostic value of carcinoembryonic antigen (CEA), cytokeratin fragment 19 (CYFRA 21-1), neuron specific enolase (NSE) and pro-gastrin-releasing peptide (ProGRP), which were routinely analysed in patients with lung tumours of unknown origin at the time of admission to hospital. Inclusion criteria were the determination of CEA (AxSYM/Abbott), CYFRA 21-1 (ElecSys/Roche) and NSE (Kryptor/Brahms). We examined 1747 patients, where 1325 suffered f...

  14. Evaluation of a new tumour marker in patients with non-small-cell lung cancer: Cyfra 21.1.

    van der Gaast, A; Schoenmakers, C. H.; Kok, T.C.; Blijenberg, B. G.; Cornillie, F.; Splinter, T A

    1994-01-01

    The Cyfra 21.1 assay is a newly developed test which measures in serum a fragment of cytokeratin 19. We evaluated this marker in 212 patients with non-small-cell lung cancer (NSCLC), predominantly stage 3a-b and 4, and compared it with three other markers: carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC) and tissue polypeptide antigen (TPA). Sensitivities for Cyfra 21.1, TPA, CEA and SCC (using cut-off levels corresponding to a 95% specificity for benign lung diseases) we...

  15. Low lying yrast states in 210 Rn and 211Rn and the competition between neutron-hole and proton excitations

    The γ-decay and nuclear structure of low lying yrast and near yrast levels in 210Rn and 211Rn have been investigated. The cascade from the yrast 6+ state in 210Rn branches to two close lying 4+ states, deduced to be complete mixtures of the 4+ states arising from the proton configuration, and from the neutron-hole intruder configuration. The influence of this proton, neutron-hole interaction on the yrast cascades in 211Rn and 206Rn, 208Rn is discussed

  16. 41 CFR 301-71.211 - Is there a minimum amount the late payment fee must exceed before we will pay it?

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false Is there a minimum amount the late payment fee must exceed before we will pay it? 301-71.211 Section 301-71.211 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES AGENCY RESPONSIBILITIES 71-AGENCY...

  17. 33 CFR 211.6 - Rights which may be granted by the Secretary of the Army in river and harbor and flood control...

    2010-07-01

    ... the Secretary of the Army in river and harbor and flood control property. 211.6 Section 211.6... and flood control property. (a) Leases. (1) The Secretary of the Army is authorized, whenever he shall deem it to be advantageous to the Government, to lease such real property under the control of...

  18. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  19. Sequential radioimmunotherapy with 177Lu- and 211At-labeled monoclonal antibody BR96 in a syngeneic rat colon carcinoma model

    Eriksson, Sophie E; Elgström, Erika; Bäck, Tom;

    2014-01-01

    UNLABELLED: Alpha-particle emitters, such as astatine-211 (211At), are generally considered suitable for the treatment of small cell clusters due to their short path length, while beta-particle emitters, for example, Lutetium-177 (177Lu), have a longer path length and are considered better for...... small, established tumors. A combination of such radionuclides may be successful in regimens of radioimmunotherapy. In this study, rats were treated by sequential administration of first a 177Lu-labeled antibody, followed by a 211At-labeled antibody 25 days later. METHODS: Rats bearing solid colon...... carcinoma tumors were treated with 400 MBq/kg body weight 177Lu-BR96. After 25 days, three groups of animals were given either 5 or 10 MBq/kg body weight of 211At-BR96 simultaneously with or without a blocking agent reducing halogen uptake in normal tissues. Control animals were not given any 211At-BR96...

  20. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity ...

  1. 77 FR 10355 - Airworthiness Directives; Rolls-Royce plc (RR) RB211-Trent 800 Series Turbofan Engines

    2012-02-22

    ... (68 FR 49344, August 18, 2003) and adding the following new AD: 2012-04-01 Rolls-Royce plc: Amendment... (68 FR 49344, August 18, 2003). (c) Applicability This AD applies to Rolls-Royce plc (RR) RB211-Trent...) 2003-16- 18, amendment 39-13271 (68 FR 49344, August 18, 2003). That AD applies to the...

  2. 76 FR 40217 - Airworthiness Directives; Rolls-Royce plc (RR) RB211-524 Series Turbofan Engines

    2011-07-08

    ... Register published on April 11, 2000 (65 FR 19477-78). Authority for This Rulemaking Title 49 of the United... Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic impact, positive or...; AD 2011-13-01] RIN 2120-AA64 Airworthiness Directives; Rolls-Royce plc (RR) RB211-524 Series...

  3. 12 CFR 211.602 - Investments by United States Banking Organizations in foreign companies that transact business in...

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Investments by United States Banking... and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM INTERNATIONAL BANKING OPERATIONS (REGULATION K) International Lending Supervision Interpretations § 211.602...

  4. Anti-CD45 radioimmunotherapy using 211At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model

    Orozco, Johnnie J.; Back, Tom; Kenoyer, Aimee L.; Balkin, Ethan R.; Hamlin, Donald K.; Wilbur, D. Scott; Fisher, Darrell R.; Frayo, Shani; Hylarides, Mark; Green, Damian J.; Gopal, Ajay K.; Press, Oliver W.; Pagel, John M.

    2013-05-15

    Anti-CD45 Radioimmunotherapy using an Alpha-Emitting Radionuclide 211At Combined with Bone Marrow Transplantation Prolongs Survival in a Disseminated Murine Leukemia Model ABSTRACT Despite aggressive chemotherapy combined with hematopoietic cell transplant (HCT), many patients with acute myeloid leukemia (AML) relapse. Radioimmunotherapy (RIT) using antibodies (Ab) labeled primarily with beta-emitting radionuclides has been explored to reduce relapse.

  5. The Arabidopsis AP2/ERF Transcription Factor RAP2.11 Modulates Plant Response to Low-Potassium Conditions

    Min Jung Kim; Daniel Ruzicka; Ryoung Shin; Daniel P.Schachtman

    2012-01-01

    Plants respond to low-nutrient conditions through metabolic and morphology changes that increase their ability to survive and grow.The transcription factor RAP2.11 was identified as a component in the response to low potassium through regulation of the high-affinity K+ uptake transporter AtHAK5 and other components of the lowpotassium signal transduction pathway.RAP2.11 was identified through the activation tagging of Arabidopsis lines that contained a luciferase marker driven by the AtHAK5 promoter that is normally only induced by low potassium.This factor bound to a GCC-box of the AtHAK5 promoter in vitro and in vivo.Transcript profiling revealed that a large number of genes were up-regulated in roots by RAP2.11 overexpression.Many regulated genes were identified to be in functional categories that are important in low-K+ signaling.These categories included ethylene signaling,reactive oxygen species production,and calcium signaling.Promoter regions of the up-regulated genes were enriched in the GCCGGC motif also contained in the AtHAK5 promoter.These results suggest that RAP2.11 regulates AtHAK5 expression under low-K+ conditions and also contributes to a coordinated response to low-potassium conditions through the regulation of other genes in the low-K+ signaling cascade.

  6. 36 CFR 211.6 - Cooperation in forest investigations or the protection, management, and improvement of the...

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Cooperation in forest... Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE ADMINISTRATION Cooperation § 211.6 Cooperation in forest investigations or the protection, management, and improvement of...

  7. Ab Initio Study of Water Adsorption and Reactivity on the (211) Surface of Anatase TiO2

    Xu, Jing; Xu, Li-Fang; Li, Zhen-Zhen; Wang, Jian-Tao; Lin, Zhe-Shuai; Liu, Kai; Cao, Yong-Ge; Selloni, Annabella

    2016-06-01

    The reactivity of the anatase TiO2 (211) surface is systematically studied by ab initio calculations of the surface energy and water-adsorption energy. We find that anatase (211) has a high surface energy of 0.97 J /m2 , close to that of the (001) surface, and the unsaturated fourfold-coordinated Ti4 atom is more reactive than the unsaturated fivefold-coordinated Ti5 atom. Accordingly, for water adsorption on the (211) surface, a dissociative form is favored on Ti4 sites, with a large adsorption energy Δ HH ,OH˜1.28 eV , while a nondissociative molecular form is favored on Ti5 sites, with a smaller adsorption energy Δ HH2O˜0.78 eV . Such distinct surface properties lead to a mixed dissociative and molecular adsorption configuration when the coverage is increased from 1 /3 to 1 monolayer. These results suggest that, similar to the (001) surface, the anatase (211) surface exhibits high reactivity and may be useful in catalytic and photocatalytic applications as well.

  8. Del(18)(q12.2q21.1) syndrome: a case report and clinical review of the literature.

    Imataka, G; Ohwada, Y; Shimura, N; Yoshihara, S; Arisaka, O

    2015-09-01

    The terminal deletion of the long arm of chromosome 18 is relatively common among cytogenetic abnormalities, which occur incidentally in approximately 1 in 40,000 live births. Proximal interstitial deletions of the long arm of chromosome 18 are less frequent. The critical region on chromosome 18 of this syndrome is del(18)(q12.2q21.1) and has recently been recognized as a new clinical entity. We describe a 8-year-old boy with developmental delay, obesity, and epilepsy, with characteristic facial anomalies in whom G-banding chromosome analysis revealed a unique karyotype of 46, XY, del(18)(q12.2q21.1). The patient was diagnosed with interstitial deletion chromosome 18q-syndrome. He received weight control therapy from a medical dietitian. For his epilepsy, he was administered oral carbamazepine at 4 mg/kg/day. At age six, he entered a special needs elementary school. After entering school, he often showed hyperkinesis, and was diagnosed with attention deficit hyperactivity disorder with mild mental retardation. Because patients with only del(18)(q12.2q21.1) have no serious associated malformations, physicians should be aware that even adult patients may have 18q-syndrome. Therefore, if epilepsy occurs in patients with minor facial anomalies, psychomotor retardation, obesity, and the possibility of 18q-syndrome with del(18)(q12.2q21.1) should be kept in mind, and chromosome testing should be performed. PMID:26400529

  9. Closure report for Corrective Action Unit 211, Area 15 EPA Farm waste sites, Nevada Test Site, Nevada

    This Closure Report summarizes the corrective actions which were completed at the Corrective Action Sites within Corrective Action Unit 211 Area 15 Farm Waste Sties at the Nevada Test Site. Current site descriptions, observations and identification of wastes removed are included on FFACO Corrective Action Site housekeeping closure verification forms

  10. Properties of pseudoscalar flavour-singlet mesons from 2+1+1 twisted mass lattice QCD

    Cichy, Krzysztof [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Poznan Univ. (Poland). Faculty of Physics; Drach, Vincent; Garcia Ramos, Elena; Jansen, Karl [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Michael, Chris [Liverpool Univ. (United Kingdom). Dept. of Mathematical Sciences; Ottnad, Konstantin; Urbach, Carsten; Zimmermann, Falk [Bonn Univ. (Germany). Inst. fuer Strahlen- und Kernphysik

    2012-11-15

    We study properties of pseudoscalar flavour-singlet mesons from Wilson twisted mass lattice QCD with N{sub f}=2+1+1 dynamical quark flavors. Results for masses are presented at three values of the lattice spacing and light quark masses corresponding to values of the pion mass from 230 MeV to 500 MeV. We briefly discuss scaling effects and the light and strange quark mass dependence of M{sub {eta}}. In addition we present an exploratory study using Osterwalder-Seiler type strange and charm valence quarks. This approach avoids some of the complications of the twisted mass heavy doublet. We present first results for matching valence and unitary actions and a comparison of statistical uncertainties.

  11. First results of ETMC simulations with Nf=2+1+1 maximally twisted mass fermions

    Baron, R; Boucaud, P; Deuzeman, A; Drach, V; Farchioni, F; Gimenez, V; Herdoiza, G; Jansen, K; Michael, C; Montvay, I; Palao, D; Pallante, E; Pène, O; Reker, S; Urbach, C; Wagner, M; Wenger, U

    2009-01-01

    We present first results from runs performed with Nf=2+1+1 flavours of dynamical twisted mass fermions at maximal twist: a degenerate light doublet and a mass split heavy doublet. An overview of the input parameters and tuning status of our ensembles is given, together with a comparison with results obtained with Nf=2 flavours. The problem of extracting the mass of the K- and D-mesons is discussed, and the tuning of the strange and charm quark masses examined. Finally we compare two methods of extracting the lattice spacings to check the consistency of our data and we present some first results of ChiPT fits in the light meson sector.

  12. Plan for the Initiation of HA-211 Furnace Operations at the Plutonium Finishing Plan (PFP)

    This plan provides a phased approach authorizing the use of three additional muffle furnaces for thermal stabilization. Achievement of Thermal Stabilization mission elements require the installation and startup of three additional muffle furnaces for the thermal stabilization of plutonium and plutonium bearing materials at the Plutonium Finishing Plant (PFP). The release to operate these additional furnaces will require an Activity Based Startup Review. The conduct of the Activity Based Startup Review (ABSR) was approved by Fluor Daniel Hanford on October 15, 1999. This plan has been developed with the objective of identifying those activities needed to guide the controlled startup of five furnaces from authorization to unrestricted operations by adding the HA-211 furnaces in an orderly and safe manner after the approval to Startup has been given

  13. Renormalization constants for $N_{\\rm f}=2+1+1$ twisted mass QCD

    Blossier, Benoit; Guichon, Pierre; Morénas, Vincent; Pène, Olivier; Rodríguez-Quintero, Jose; Zafeiropoulos, Savvas

    2014-01-01

    We summarize recent non-perturbative results obtained for the renormalization constants computed in the RI'-MOM scheme for $N_{\\rm f}=2+1+1$ twisted mass QCD. Our implementation employs the Iwasaki gauge action and four dynamical degenerate twisted mass fermions. Renormalization constants for scalar, pseudo-scalar, vector and axial operators, as well as the quark propagator renormalization, are computed at three different values of the lattice spacing, two different volumes and several values of the twisted mass. Our method allows for a precise cross-check of the running, because of the particular proper treatment of the hypercubic artifacts. Preliminary results for twist-2 operators are also presented.

  14. Project Execution Plan for Project W-211 Initial Tank Retrieval Systems (ITRS)

    This Project Execution Plan documents the methodology for managing Project W-211. Project W-211, Initial Tank Retrieval Systems (ITRS), is a fiscal year 1994 Major Systems Acquisition that will provide systems for retrieval of radioactive wastes from selected double-shell tanks (DST). The contents of these tanks are a combination of supernatant liquids and settled solids. To retrieve waste from the tanks, it is first necessary to mix the liquid and solids prior to transferring the slurry to alternative storage or treatment facilities. The ITRS will provide systems to mobilize the settled solids and transfer the wastes out of the tanks. In so doing, ITRS provides feed for the future waste treatment plant, allows for consolidation of tank solids to manage space within existing DST storage capacity, and supports continued safe storage of tank waste. The ITRS scope has been revised to include waste retrieval systems for tanks AP-102, AP-104, AN-102, AN-103, AN-104, AN-105, AY-102, AZ-102, and SY-102. This current tank selection and sequence provides retrieval systems supporting the River Protection Project (RF'P) Waste Treatment Facility and sustains the ability to provide final remediation of several watch list DSTs via treatment. The ITRS is configured to support changing program needs, as constrained by available budget, by maintaining the flexibility for exchanging tanks requiring mixer pump-based retrieval systems and shifting the retrieval sequence. Preliminary design was configured such that an adequate basis exists for initiating Title II design of a mixer pump-based retrieval system for any DST. This Project Execution Plan (PEP), derived from the predecessor Project Management Plan, documents the methodology for managing the ITRS, formalizes organizational responsibilities and interfaces, and identifies project requirements such as change control, design verification, systems engineering, and human factors engineering

  15. In vitro experimental {sup 211}At-anti-CD33 antibody therapy of leukaemia cells overcomes cellular resistance seen in vivo against gemtuzumab ozogamicin

    Petrich, Thorsten; Korkmaz, Zekiye; Krull, Doris; Meyer, Geerd J.; Knapp, Wolfram H. [Hanover University School of Medicine, Department of Nuclear Medicine, Hanover (Germany); Froemke, Cornelia [Hanover University School of Medicine, Department of Biometry, Hanover (Germany)

    2010-05-15

    Monoclonal anti-CD33 antibodies conjugated with toxic calicheamicin derivative (gemtuzumab ozogamicin, GO) are a novel therapy option for acute myeloid leukaemia (AML). Key prognostic factors for patients with AML are high CD33 expression on the leukaemic cells and the ability to overcome mechanisms of resistance to cytotoxic chemotherapies, including drug efflux or other mechanisms decreasing apoptosis. Alpha particle-emitting radionuclides overwhelm such anti-apoptotic mechanisms by producing numerous DNA double-stranded breaks (DSBs) accompanied by decreased DNA repair. We labelled anti-CD33 antibodies with the alpha-emitter {sup 211}At and compared survival of leukaemic HL-60 and K-562 cells treated with the {sup 211}At-labelled antibodies, GO or unlabelled antibodies as controls. We also measured caspase-3/7 activity, DNA fragmentation and necrosis in HL-60 cells after treatment with the different antibodies or with free {sup 211}At. The mean labelling ratio of {sup 211}At-labelled antibodies was 1:1,090 {+-} 364 (range: 1:738-1:1,722) in comparison to 2-3:1 for GO. Tumour cell binding of {sup 211}At-anti-CD33 was high in the presence of abundant CD33 expression and could be specifically blocked by unlabelled anti-CD33. {sup 211}At-anti-CD33 decreased survival significantly more than did GO at comparable dilution (1:1,000). No significant differences in induction of apoptosis or necrosis or DNA DSB or in decreased survival were observed after {sup 211}At-anti-CD33 (1:1,090) versus GO (1:1) treatment. Our results suggest that {sup 211}At is a promising, highly cytotoxic radioimmunotherapy in CD33-positive leukaemia and kills tumour cells more efficiently than does calicheamicin-conjugated antibody. Labelling techniques leading to higher chemical yield and specific activities must be developed to increase {sup 211}At-anti-CD33 therapeutic effects. (orig.)

  16. The Commentary on Aristotle’s Treatise On the Heavens in Marcianus gr. 211 and Bessarion’s Autograph Parisinus gr. 2042

    Vito Lorusso

    2014-10-01

    Full Text Available This article deals with Bessarion’s excerpts from Aristotle’s treatise On the Heavens in Parisinus gr. 2042 as well as with Marcianus gr. 211 that Bessarion used as model. A further topic is the exploration of the commentaries to Aristotle’s treatise On Generation and Corruption written down by Bessarion on the edges of Marcianus gr. 211. Finally, the article touches upon three commentaries to Aristotle’s On the Heavens contained in Marcianus gr.211 in order to study their sources as well as their transmission in other Greek manuscripts.

  17. Erzeugung und Folgechemie von Bicyclo[2.1.1]hex-1-ylhalogen- und Bicyclo[2.2.1]hept-1-ylhalogencarbenen

    Dorok, Sascha

    2003-01-01

    Der Zugang zu 1,4-disubstituierten Bicyclo[2.1.1]hexanen konnte verbessert werden. Ausgehend von Cyclopentan-1,3-dicarbonsäuredimethylester konnte Bicyclo[2.1.1]hexan-1,4-dicarbonsäuredimethylester mit Ausbeuten bis zu 58% synthetisiert werden. Hierbei wurde das Bis-Enolat des Diesters in einem Eintopf-Verfahren mit Diiodmethan zweifach alkyliert. Diese Methode zeigt eine hohe Empfindlichkeit gegenüber Veränderungen verschiedener Parameter. Das Verhalten von bicyclo[2.1.1]hexyl-substituierte...

  18. Wet-chemistry method for the separation of no-carrier-added 211At/211gPo from 209Bi target irradiated by alpha-beam in cyclotron

    We present a fast and effective wet-chemistry method, used to obtain the pure alpha-emitter 211At/211gPo (T1/2 = 7.214 h/516 ms), produced by 209Bi(α,2n) reaction in NCA form. It is a selective radiochemical separation of the At radionuclides from the target and the impurities, characterized by a radionuclidic purity close to 100%, based on the dissolution and the dilution of the irradiated target in acidic medium, on the extraction with DIPE, followed by the back-extraction with NaOH. As a result, we obtain a yield greater than 90-97% in a range from 0.75M to 2.00M. (author)

  19. A Survey on the E- resource Construction of University Libraries in"211 Project"%“211工程”高校图书馆电子资源网页建设调查

    蒋鸿标

    2011-01-01

    According to the survey on the web pages of 30 libraries of "211 project", the paper puts forward some solutions to the problems of web page designing, column setting, standard of database classification and the list of databases, etc.%对“211工程”高校图书馆中的30所进行网页调查,就其电子资源建设中的网页设计、类目设置、数据库分类标准、数据库列表等方面存在的问题,提出解决办法。

  20. InSb(111)、(211)及(110)晶面腐蚀极性研究%Effect of the polarity of InSb (111),(211) and (110) planes on etching

    马攀; 陈湘伟; 司俊杰

    2009-01-01

    极性是InSb晶体结构的一种属性,文中研究了这种极性对InSb晶片湿法腐蚀的影响,并对这种极性产生的原因进行了分析.结果表明,对于工艺中常用的CP4腐蚀液,(111)及(211)晶面腐蚀时表现出极性,(111)A面平均腐蚀速率为2.2 μm/s,(111)B面的平均腐蚀速率为3.6 μm/s;(211)A面的平均腐蚀速率为3 μm/s,(211)B面的平均腐蚀速率为4.8 μm/s;而(110)晶面在腐蚀时未表现出极性效应,只存在一种腐蚀速率为4 μm/s.

  1. Hyperfine structure of the 6d2D3/2 level in trapped short-lived 211,209Ra+ ions

    The hyperfine structure of short-lived trapped 211,209Ra+ ions was investigated by means of laser spectroscopy. The hyperfine structure constants A and B of the 6d2D3/2 level were determined. There is a 2.2 standard deviation difference between the theoretical and the more accurate experimental value for the B coefficient of 211Ra+. These measurements provide a test for the atomic theory required for upcoming experiments on atomic parity violation and atomic clocks. -- Highlights: → The hyperfine structure of trapped 211,209Ra+ was studied with laser spectroscopy. → The hyperfine structure constants A and B of the 6d2D3/2 level were determined. → A 2.2σ difference with theory is found for the B coefficient of 211Ra+. → These measurements test atomic theory, needed in atomic parity violation experiments.

  2. Observation of a narrow structure in the pp elastic scattering at Tkin = 2.11 GeV

    The angular dependences of the pp elastic scattering analyzing power, spin correlation, depolarization transfer were measured in the angular range from 60 degrees to 97 degrees CM at 14 energies between 1.96 and 2 .23 GeV. At fixed angles two maxima were observed in the analyzing Power energy dependence, both below and above 2.11 GeV. Furthermore a rapid decrease Of the spin correlation Parameter at 90 degrees CM occurs around this energy. The observables allow determination of the absolute values of three nonvanishing pp amplitudes at 90 degrees. The energy dependence of the spin-single amplitude shows a shoulder centered at 2.11 GeV, while the spin-triplet amplitudes are decreasing functions of energy snowing no evidence of structure. All experimental data are listed in tables and their energy dependences are shown in figures

  3. Differential gene expression in human fibroblasts after alpha-particle emitter (211)At compared with (60)Co irradiation

    Danielsson, Anna; Claesson, Kristina; Parris, Toshima Z; Helou, Khalil; Nemes, Szilárd; Elmroth, Kecke; Elgqvist, Jörgen; Jensen, Holger; Hultborn, Ragnar

    2013-01-01

    Purpose: The aim of this study was to identify gene expression profiles distinguishing alpha-particle (211)At and (60)Co irradiation. Materials and methods: Gene expression microarray profiling was performed using total RNA from confluent human fibroblasts 5 hours after exposure to (211)At labeled...... trastuzumab monoclonal antibody (0.25, 0.5, and 1 Gy) and (60)Co (1, 2, and 3 Gy). Results: We report gene expression profiles that distinguish the effect different radiation qualities and absorbed doses have on cellular functions in human fibroblasts. In addition, we identified commonly expressed transcripts...... transcription, cell cycle regulation, and cell cycle arrest, whereas mitosis, spindle assembly checkpoint, and apoptotic chromosome condensation were uniquely enriched for alpha particle irradiation. Conclusions: LET-dependent transcriptional modulations were observed in human fibroblasts 5 hours after...

  4. Growth conditions and properties of Y123/Y211 and Y123/Y2O3 bulks

    Radušovská, M.; Volochová, D.; Antal, V.; Piovarči, S.; Diko, P.

    2016-03-01

    The single-grain YBCO samples were prepared by TSMG process. Two nominal compositions: 1 mol.Y123 + 0.25 mol.Y2O3 + 1.0 wt.% CeO2 (Y123/Y2O3) or 70 wt.% Y-123 + 30 wt.% Y-211 (Y123/Y211) and 1.0 wt.% CeO2 and two different types of substrates were tested. It is shown that the growth rate in both systems is influenced by segregation of CuO in to the nonsolidified part of the sample what causes stop of isothermal growth. Measured melt losses are lower for ZrO2 substrate than for Y2O3/Yb2O3 substrate what influence final microstructure of prepared bulk superconductors.

  5. Treatment of HER2-positive breast carcinomatous meningitis with intrathecal administration of {alpha}-particle-emitting {sup 211}At-labeled trastuzumab

    Boskovitz, Abraham; McLendon, Roger E.; Okamura, Tatsunori [Department of Pathology, Duke University Medical Center, Durham, NC 27710 (United States); Sampson, John H. [Department of Surgery, Duke University Medical Center, Durham, NC 27710 (United States); Bigner, Darell D. [Department of Pathology, Duke University Medical Center, Durham, NC 27710 (United States); Zalutsky, Michael R. [Department of Radiology, Duke University Medical Center, Durham, NC 27710 (United States)], E-mail: zalut001@mc.duke.edu

    2009-08-15

    Introduction: Carcinomatous meningitis (CM) is a devastating disease characterized by the dissemination of malignant tumor cells into the subarachnoid space along the brain and spine. Systemic treatment with monoclonal antibody (mAb) trastuzumab can be effective against HER2-positive systemic breast carcinoma but, like other therapies, is ineffective against CM. The goal of this study was to evaluate the therapeutic effect of {alpha}-particle emitting {sup 211}At-labeled trastuzumab following intrathecal administration in a rat model of breast carcinoma CM. Methods: Athymic rats were injected intrathecally with MCF-7/HER2-18 breast carcinoma cells through a surgically implanted indwelling intrathecal catheter. In Experiment 1, animals received 33 or 66 {mu}Ci {sup 211}At-labeled trastuzumab, cold trastuzumab or saline. In Experiment 2, animals were inoculated with a lower tumor burden and received 46 or 92 {mu}Ci {sup 211}At-labeled trastuzumab or saline. In Experiment 3, animals received 28 {mu}Ci {sup 211}At-labeled trastuzumab, 30 {mu}Ci {sup 211}At-labeled TPS3.2 control mAb or saline. Histopathological analysis of the neuroaxis was performed at the end of the study. Results: In Experiment 1, median survival increased from 21 days for the saline and cold trastuzumab groups to 45 and 48 days for 33 and 66 {mu}Ci {sup 211}At-labeled trastuzumab, respectively. In Experiment 2, median survival increased from 23 days for saline controls to 68 and 92 days for 46 and 92 {mu}Ci {sup 211}At-labeled trastuzumab, respectively. In Experiment 3, median survival increased from 20 days to 29 and 36 days for animals treated with {sup 211}At-labeled TPS3.2 and {sup 211}At-labeled trastuzumab, respectively. Long-term survivors were observed exclusively in the {sup 211}At-trastuzumab-treated groups. Conclusion: Intrathecal {sup 211}At-labeled trastuzumab shows promise as a treatment for patients with HER2-positive breast CM.

  6. Diagnostic Significance of Combining Telomerase Activity with CYFRA21-1 Level in Differentiating Malignant Pleural Effusion Caused by Lung Cancer from Benign Pleural Effusio

    Li, Hongmei; Junhua FU; Yuande XIU; Zhou, Qinghua

    2010-01-01

    Background and objective Telomerase and CYFRA21-1 may be positively expressed in malignant pleural effusion, but the sensitivity and specificity of single tumor marker were low. The aim of this study is to investigate the diagnostic value of combining determination of telomerase activity and CYFRA21-1 levels in differentiating benign from malignant pleural effusion caused by lung cancer. Methods 80 patients with malignant and 50 patients with benign pleural effusion were enrolled into this st...

  7. Cyfra 21-1 as a serum tumor marker for follow up of patients with laryngeal and hypopharyngeal squamous cell carcinoma

    Al-Shagahin, Hani

    2010-01-01

    AIM: To evaluate the importance and potential of Cyfra21-1 as a tumor marker (TM) for follow-up of patients with squamous cell carcinoma (SCC) in laryngeal and hypopharyngeal cancer. PATIENTS AND METHODS: Cyfra21-1 serum levels of 50 patients with laryngeal and hypopharyngeal SCC were evaluated by ECLIA assay. Statistical analysis was performed using Kruskal-Wallis and Jonckheere-Terpstra tests. RESULTS: There was no significant c...

  8. Cytokeratin 19-fragments (CYFRA 21-1) as a novel serum biomarker for response and survival in patients with advanced pancreatic cancer

    Boeck, S.; Wittwer, C; Heinemann, V; Haas, M.; Kern, C; Stieber, P; Nagel, D; Holdenrieder, S

    2013-01-01

    Background: CYFRA 21-1 serves as biomarker in several epithelial malignancies. However, its role in pancreatic cancer (PC) has not yet been investigated. Methods: Within a prospective single-centre study serial blood samples were collected from patients with confirmed advanced PC. Pre-treatment values and weekly measurements of CYFRA 21-1, carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen (assessed by Elecsys 2010, Roche Diagnostics) during palliative first-line chemotherapy we...

  9. 5 CFR 892.211 - What options are available to me if I go on a period of leave without pay (LWOP) or other types...

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false What options are available to me if I go on a period of leave without pay (LWOP) or other types of non-pay status? 892.211 Section 892.211... What options are available to me if I go on a period of leave without pay (LWOP) or other types of...

  10. Durable donor engraftment after radioimmunotherapy using α-emitter astatine-211-labeled anti-CD45 antibody for conditioning in allogeneic hematopoietic cell transplantation.

    Chen, Yun; Kornblit, Brian; Hamlin, Donald K; Sale, George E; Santos, Erlinda B; Wilbur, D Scott; Storer, Barry E; Storb, Rainer; Sandmaier, Brenda M

    2012-02-01

    To reduce toxicity associated with external γ-beam radiation, we investigated radioimmunotherapy with an anti-CD45 mAb labeled with the α-emitter, astatine-211 ((211)At), as a conditioning regimen in dog leukocyte antigen-identical hematopoietic cell transplantation (HCT). Dose-finding studies in 6 dogs treated with 100 to 618 μCi/kg (211)At-labeled anti-CD45 mAb (0.5 mg/kg) without HCT rescue demonstrated dose-dependent myelosuppression with subsequent autologous recovery, and transient liver toxicity in dogs treated with (211)At doses less than or equal to 405 μCi/kg. Higher doses of (211)At induced clinical liver failure. Subsequently, 8 dogs were conditioned with 155 to 625 μCi/kg (211)At-labeled anti-CD45 mAb (0.5 mg/kg) before HCT with dog leukocyte antigen-identical bone marrow followed by a short course of cyclosporine and mycophenolate mofetil immunosuppression. Neutropenia (1-146 cells/μL), lymphopenia (0-270 cells/μL), and thrombocytopenia (1500-6560 platelets/μL) with prompt recovery was observed. Seven dogs had long-term donor mononuclear cell chimerism (19%-58%), whereas 1 dog treated with the lowest (211)At dose (155 μCi/kg) had low donor mononuclear cell chimerism (5%). At the end of follow-up (18-53 weeks), only transient liver toxicity and no renal toxicity had been observed. In conclusion, conditioning with (211)At-labeled anti-CD45 mAb is safe and efficacious and provides a platform for future clinical trials of nonmyeloablative transplantation with radioimmunotherapy-based conditioning. PMID:22134165

  11. Characterization of the genetic elements required for site-specific integration of plasmid pSE211 in Saccharopolyspora erythraea.

    Brown, D P; Idler, K B; Katz, L

    1990-04-01

    The 18.1-kilobase plasmid pSE211 integrates into the chromosome of Saccharopolyspora erythraea at a specific attB site. Restriction analysis of the integrated plasmid, pSE211int, and adjacent chromosomal sequences allowed identification of attP, the plasmid attachment site. Nucleotide sequencing of attP, attB, attL, and attR revealed a 57-base-pair sequence common to all sites with no duplications of adjacent plasmid or chromosomal sequences in the integrated state, indicating that integration takes place through conservative, reciprocal strand exchange. An analysis of the sequences indicated the presence of a putative gene for Phe-tRNA at attB which is preserved at attL after integration has occurred. A comparison of the attB site for a number of actinomycete plasmids is presented. Integration at attB was also observed when a 2.4-kilobase segment of pSE211 containing attP and the adjacent plasmid sequence was used to transform a pSE211- host. Nucleotide sequencing of this segment revealed the presence of two complete open reading frames (ORFs) and a segment of a third ORF. The ORF adjacent to attP encodes a putative polypeptide 437 amino acids in length that shows similarity, at its C-terminal domain, to sequences of site-specific recombinases of the integrase family. The adjacent ORF encodes a putative 98-amino-acid basic polypeptide that contains a helix-turn-helix motif at its N terminus which corresponds to domains in the Xis proteins of a number of bacteriophages. A proposal for the function of this polypeptide is presented. The deduced amino acid sequence of the third ORF did not reveal similarities to polypeptide sequences in the current data banks. PMID:2180909

  12. Assessment of confounding factors affecting the tumor markers SMRP, CA125, and CYFRA21-1 in serum

    Daniel Gilbert Weber; Georg Johnen; Dirk Taeger; Anne Weber; Isabelle Mercedes Gross; Beate Pesch; Thomas Kraus; Thomas Brüning; Monika Gube

    2010-01-01

    The purpose of this analysis was to evaluate if serum levels of potential tumor markers for the diagnosis of malignant mesothelioma and lung cancer are affected by confounding factors in a surveillance cohort of workers formerly exposed to asbestos. SMRP, CA125, and CYFRA21-1 concentrations were determined in about 1,700 serum samples from 627 workers formerly exposed to asbestos. The impact of factors that could modify the concentrations of the tumor markers was examined with linear mixed mo...

  13. CYFRA 21-1 in non-small cell lung cancer--standardisation and application during diagnosis

    Pavićević, Radomir; Bubanović, Gordana; Franjević, Ana; Stančić-Rokotov, Dinko; Samaržija, Miroslav

    2008-01-01

    There is no ideal tumour marker at present. The clinical application of CYFRA 21-1 is possible once a thorough standardisation process is carried out. Standardisation is achieved by determining the reference range in asymptomatic population, benign and malignant lung diseases, and benign and malignant diseases of other organs. Furthermore, it depends on knowledge of research population characteristics, patient medical histories and individual diagnostic procedure results, the size...

  14. Engineer/constructor description of work for Tank 241-SY-102 retrieval system, project W-211, initial tank retrieval systems

    This document provides a description of work for the design and construction of a waste retrieval system for Tank 241-SY-102. The description of work includes a working estimate and schedule, as well as a narrative description and sketches of the waste retrieval system. The working estimate and schedule are within the established baselines for the Tank 241-SY-102 retrieval system. The technical baseline is provided in Functional Design Criteria, WHC-SD-W211-FDC-001, Revision 2

  15. Engineered Modular Recombinant Transporters: Application of New Platform for Targeted Radiotherapeutic Agents to α-Particle Emitting 211At

    Purpose: To generate and evaluate a modular recombinant transporter (MRT) for targeting 211At to cancer cells overexpressing the epidermal growth factor receptor (EGFR). Methods and Materials: The MRT was produced with four functional modules: (1) human epidermal growth factor as the internalizable ligand, (2) the optimized nuclear localization sequence of simian vacuolating virus 40 (SV40) large T-antigen, (3) a translocation domain of diphtheria toxin as an endosomolytic module, and (4) the Escherichia coli hemoglobin-like protein (HMP) as a carrier module. MRT was labeled using N-succinimidyl 3-[211At]astato-5-guanidinomethylbenzoate (SAGMB), its 125I analogue SGMIB, or with 131I using Iodogen. Binding, internalization, and clonogenic assays were performed with EGFR-expressing A431, D247 MG, and U87MG.wtEGFR human cancer cell lines. Results: The affinity of SGMIB-MRT binding to A431 cells, determined by Scatchard analysis, was 22 nM, comparable to that measured before labeling. The binding of SGMIB-MRT and its internalization by A431 cancer cells was 96% and 99% EGFR specific, respectively. Paired label assays demonstrated that compared with Iodogen-labeled MRT, SGMIB-MRT and SAGMB-MRT exhibited more than threefold greater peak levels and durations of intracellular retention of activity. SAGMB-MRT was 10-20 times more cytotoxic than [211At]astatide for all three cell lines. Conclusion: The results of this study have demonstrated the initial proof of principle for the MRT approach for designing targeted α-particle emitting radiotherapeutic agents. The high cytotoxicity of SAGMB-MRT for cancer cells overexpressing EGFR suggests that this 211At-labeled conjugate has promise for the treatment of malignancies, such as glioma, which overexpress this receptor

  16. Engineer/constructor description of work for Tank 241-SY-102 retrieval system, project W-211, initial tank retrieval systems

    Rieck, C.A. [Westinghouse Hanford Co., Richland, WA (United States)

    1996-02-01

    This document provides a description of work for the design and construction of a waste retrieval system for Tank 241-SY-102. The description of work includes a working estimate and schedule, as well as a narrative description and sketches of the waste retrieval system. The working estimate and schedule are within the established baselines for the Tank 241-SY-102 retrieval system. The technical baseline is provided in Functional Design Criteria, WHC-SD-W211-FDC-001, Revision 2.

  17. Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model

    Green, Damian J.; Shadman, Mazyar; Jones, Jon C.; Frayo, Shani; Kenoyer, Aimee L.; Hylarides, Mark; Hamlin, Donald K.; Wilbur, D. Scott; Balkan, Ethan R.; Lin, Yukang; Miller, Brian W.; Frost, Sophia; Gopal, Ajay K.; Orozco, Johnnie J.; Gooley, Ted; Laird, Kelley L.; Till, B. G.; Back, Tom; Sandmaier, B. M.; Pagel, John M.; Press, Oliver W.

    2015-03-26

    Alpha emitting radionuclides release a large amount of energy within a few cell diameters and may be particularly effective for radioimmunotherapy targeting minimal residual disease (MRD) conditions in which micrometastatic disease satellites are broadly distributed. To evaluate this hypothesis, 211At conjugated 1F5 mAb (anti-CD20) was studied in both bulky lymphoma tumor xenograft and MRD animal models. Superior treatment responses to 211At conjugated 1F5 mAb were evident in the MRD setting. Lymphoma xenograft tumor bearing animals treated with doses of up to 48µCi of anti-CD20 211At-decaborate [211At-B10-1F5] experienced modest responses (0% cures but 2-3-fold prolongation of survival compared to negative controls). In contrast, 70% of animals in the MRD lymphoma model demonstrated complete eradication of disease when treated with 211At-B10-1F5 at a radiation dose that was less than one-third (15 µCi) of the highest dose given to xenograft animals. Tumor progression among untreated control animals in both models was uniformly lethal. After 130 days, no significant renal or hepatic toxicity is observed in the cured animals receiving 15 µCi of 211At-B10-1F5. These findings suggest that in a MRD lymphoma model, where isolated cells and tumor microclusters prevail, α-emitters may be uniquely efficacious.

  18. Overexpression of a maize SNF-related protein kinase gene, ZmSnRK2.11, reduces salt and drought tolerance in Arabidopsis

    ZHANG Fan; CHEN Xun-ji; WANG Jian-hua; ZHENG Jun

    2015-01-01

    Sucrose non-fermenting-1 related protein kinase 2 (SnRK2) is a unique family of protein kinases associated with abiotic stress signal transduction in plants. In this study, a maize SnRK2 gene ZmSnRK2.11 was cloned and characterized. The results showed that ZmSnRK2.11 is up-regulated by high-salinity and dehydration treatment, and it is expressed mainly in maize mature leaf. A transient expression assay using onion epidermal cel s revealed that ZmSnRK2.11-GFP fusion proteins are localized to both the nucleus and cytoplasm. Overexpressing-ZmSnRK2.11 in Arabidopsis resulted in salt and drought sensitivity phenotypes that exhibited an increased rate of water loss, reduced relative water content, delayed stoma closure, accumulated less free proline content and increased malondialdehyde (MDA) content relative to the phenotypes observed in wild-type (WT) control. Furthermore, overexpression of ZmSnRK2.11 up-regulated the expression of the genes ABI1 and ABI2 and decreased the expression of DREB2A and P5CS1. Taken together, our results suggest that ZmSnRK2.11 is a possible negative regulator involved in the salt and drought stress signal transduction pathways in plants.

  19. Study of a new tumor marker, CYFRA 21-1, in squamous cell carcinoma of the cervix, and comparison with squamous cell carcinoma antigen

    The diagnosis value of a new tumor marker, CYFRA 21-1, was studied in the blood samples collected from 22 controls, and 87 pre-treatment patients with squamous cell carcinoma of the cervix. Sensitivity and specificity of CYFRA 21-1 was was compared with those of squamous cell carcinoma antigen (SCC) measured in the sera of the same patients. Serum CYFRA 21-1 levels were higher in patients with squamous cell carcinoma than in controls (p < 0.05), and correlated with FIGO stage (Stage IIb-IV vs. Stage Ib-IIa, p = 0.0477). Using 2.5 ng/ml as cut-off value, elevated CYFRA 21-1 levels were found in 13.6% of controls, 34.8% of patients with Stage Ib-IIa squamous cell carcinoma of the cervix, and 63.5% of patients with Stage IIb-IV squamous cell carcinoma of the cervix. However, there was less sensitivity and specificity of CYFRA 21-1 than those of SCC in detecting squamous cell carcinoma of the cervix. CYFRA 21-1 may not be a better tumor marker than SCC for squamous cell carcinoma of the cervix. (author)

  20. Combination of IGF-1 with CEA, CYFRA21-1, NSE for the diagnosis and prediction of treatment response in lung cancer

    Objective: To evaluate four tumor markers of insulin-like growth factor 1((IGF-1), CEA, cytokeratin fragment antigen 21-1 (CYFRA21-1), neuron-specific enolase (NSE) for the diagnosis and prediction of treatment response in human lung cancer. Methods: Serum samples were taken from three groups: 91 patients with lung cancer, 30 healthy adults and 15 patients with benign pulmonary diseases. Serum IGF-1 was assayed by radioimmunoassay and CEA, CYFRA21-1, and NSE by electrochemiluminescence immunoassay. The differences among the three groups were determined by Kruskal-Wallis one-way analysis of variance (ANOVA) and with Mann-Whitney rank-sum test. Diagnostic efficacy was evaluated by ROC curves. Results: The four serum tumor marker levels were significantly higher in lung cancer group, as compared with the benign and the healthy (IGF-1: χ2=26.95, P2=49.11, P2=40.63, P2=14.76; P2=5.99, P=0.014; CYFRA21-1: χ2=4.99, P=0.025) in cancer group. Conclusions: Serum IGF-1, CEA, CYFRA21-1 and NSE are all valuable for lung cancer diagnosis and the combination of those parameters can enhance the diagnostic efficiency. Serum IGF-1 and CYFRA21-1 may also be useful for evaluating the treatment response in lung cancer. (authors)

  1. Study on the relationship between serum concentration of CYFRA21-1 and pathological staging in patients with non-small cell lung cancer

    Objective: To study the relationship between of serum concentrations of CYFRA21-1 and to pathological staging in patients with non-small cell lung cancer. Methods: Serum concentrations of CYFRA21-1 were determined with IRMA in 224 patients with non-small cell lung cancer. Results: The serum CYFRA21-1 levels in patients with non-small cell lung carcinoma increased gradually as the tumor size enlarged. Levels in patients of T2 and T3 stages were significantly higher than those in patients of T1 stage, but the difference between those in patients of T2 stage and T3 stage were not significant. The serum CYFRA21-1 levels also increased as the number of lymph nodes with metastasis increased. Differences of serum levels of CYFRA21-1 in patients of consecutive lymph node stages were all significant. Conclusion: Preoperative detection of the serum concentration of CYFRA21-1 in patient with non-small cell lung cancer has important clinical significance on the judgement of T, N stages. (authors)

  2. Resolving the High Energy Universe with Strong Gravitational Lensing: The Case of PKS 1830-211

    Barnacka, Anna; Dell'Antonio, Ian P; Benbow, Wystan

    2015-01-01

    Gravitational lensing is a potentially powerful tool for elucidating the origin of gamma-ray emission from distant sources. Cosmic lenses magnify the emission from distance sources and produce time delays between mirage images. Gravitationally-induced time delays depend on the position of the emitting regions in the source plane. The Fermi/LAT satellite continuously monitors the entire sky and detects gamma-ray flares, including those from gravitationally-lensed blazars. Therefore, temporal resolution at gamma-ray energies can be used to measure these time delays, which, in turn, can be used to resolve the origin of the gamma-ray flares spatially. We provide a guide to the application and Monte Carlo simulation of three techniques for analyzing these unresolved light curves: the Autocorrelation Function, the Double Power Spectrum, and the Maximum Peak Method. We apply these methods to derive time delays from the gamma-ray light curve of the gravitationally-lensed blazar PKS 1830-211. The result of temporal an...

  3. Evaluation of a new tumor marker, CYFRA 21-1, in patients with primary lung cancer

    We measured the level of serum CYFRA 21-1 (CYFRA) in 38 primary lung cancer patients (21 adenocarcinomas (ACs), 12 squamous cell carcinomas (SqCCs) and 5 small cell carcinomas (SmCCs)) before undergoing therapy using a 'CYFRA immunoradiometric assay kit'. We thus determined the CYFRA cut-off level to be 1.7 ng/ml. We also measured both the carcinoembryonic antigen (CEA), and the squamous cell carcinoma antigen (SCC) levels. The positive rate for CYFRA in patients with lung cancer was 71% and such positivity was related to their histology (SqCCs, SmCCs 100%; ACs 48%). The level of CYFRA was significantly higher in SqCCs than in either ACs or SmCCs. No significant differences were observed in the serum CYFRA value among the various clinical stages. In addition, no significant correlation was seen between CYFRA and SCC, or between CYFRA and CEA. Among the various clinical stages of SqCCs, the positive rate of CYFRA was higher in the early clinical stages than in SCC. Our findings therefore support the usefulness of CYFRA as a marker of SqCCs. (author)

  4. Organosulfur chemistry on W(211) surfaces. 2. A comparison of benzene, thiophene, and tetrahydrothiophene

    The interactions of benzene, thiophene, and tetrahydrothiophene with clean, oxidized, and sulfided W(211) surfaces were studied with LEED, AES, and temperature programmed reaction. Benzene and thiophene appear to absorb as bases making π-bonds to the surface. Benzene decomposed to yield adsorbed carbon and hydrogen. Thiophene appeared to undergo electrophilic attack at the 2-position forming a carbon bound surface intermediate. This surface intermediate was desulfurized and the resulting hydrocarbon surface intermediate underwent C-C bond scission forming C3 hydrocarbons as the dominate desorption product. The electrophilic attack at the 2-position was shown by methyl group elimination from 2,5-dimethylthiophene. Adsorbed oxygen and sulfur enhanced the adsorption of benzene and thiophene by making the surface more acidic. Tetrahydrothiophene (THT) appear to adsorb as a base, forming a bond between the S(3p) electrons and the surface. Desulfurization of adsorbed THT led to C4 hydrocarbons as the dominate desorption product. Adsorbed oxygen and sulfur inhibited reaction of THT. These results suggest that the surface reactivity and subsequent desulfurization of thiophene is controlled by electrophilic attack on the aromatic ring, and the ensuing reduction of resonance stabilization facilitates sulfur removal. 41 references, 8 figures, 4 tables

  5. ART: Surveying the Local Universe at 2-11 keV

    O'Dell, S. L.; Ramsey, B. D.; Adams, M. L.; Brandt, W. N.; Bubarev, M. V.; Hassinger, G.; Pravlinski, M.; Predehl, P.; Romaine, S. E.; Swartz, D. A.; Urry, C. M.; Vikhlinin, A.; Weisskopf, M. C.

    2008-01-01

    The Astronomical Rontgen Telescope (ART) is a medium-energy x-ray telescope system proposed for the Russian-led mission Spectrum Rontgen-Gamma (SRG). Optimized for performance over the 2-11-keV band, ART complements the softer response of the SRG prime instrument-the German eROSITA x-ray telescope system. The anticipated number of ART detections is 50,000-with 1,000 heavily-obscured (N(sub H)> 3x10(exp 23)/sq cm) AGN-in the SRG 4-year all-sky survey, plus a comparable number in deeper wide-field (500 deg(sup 2) total) surveys. ART's surveys will provide a minimally-biased, nearly-complete census of the local Universe in the medium-energy x-ray band (including Fe-K lines), at CCD spectral resolution. During long (approx.100-ks) pointed observations, ART can obtain statistically significant spectral data up to about 15 keY for bright sources and medium-energy x-ray continuum and Fe-K-line spectra of AGN detected with the contemporaneous NuSTAR hard-x-ray mission.

  6. Magnetic resonance imaging with 21.1 T and pathological correlations. Diffuse lewy body disease

    We investigated fixed basal ganglia specimens, including globus pallidus and putamen, with 21.1-Tesla MRI allowing us to achieve a microscopic level resolution from a patient with pathologically confirmed dementia with Lewy bodies (DLB) and a neurologically normal control case. We acquired T2 and T2* weighted images that demonstrated diffuse and patchy lower intensities in the basal ganglia compared to control. There are several paramagnetic substances in brain tissue that could potentially reduce both T2 and T2* relaxation times, including ferritin, iron (Fe3+), manganese, copper and others. Because iron is most abundant, low intensities on T2 and T2* weighted images most likely reflect iron deposition. Iron, especially Fe3+, deposition was visible in the pathological specimens stained with Prussian blue after images were obtained. Although radiological-pathological comparisons are not straightforward with respect to either the MRI signal or relaxation quantification, there appears to be a correlation between the relative increase in iron as assessed by Prussian blue staining and the decrease in T2* value between the DLB and control specimens. As such, this exceptionally high field MRI technique may provide details about the role that iron deposition plays either directly or indirectly as a biomarker in neurodegenerative processes. (author)

  7. [Magnetic resonance imaging with 21.1 T and pathological correlations--diffuse Lewy body disease].

    Fujioka, Shinsuke; Murray, Melissa E; Foroutan, Parastou; Schweitzer, Katherine J; Dickson, Dennis W; Grant, Samuel C; Wszolek, Zbigniew K

    2011-08-01

    We investigated fixed basal ganglia specimens, including globus pallidus and putamen, with 21.1-Tesla MRI allowing us to achieve a microscopic level resolution from a patient with pathologically confirmed dementia with Lewy bodies (DLB) and a neurologically normal control case. We acquired T2 and T2 * weighted images that demonstrated diffuse and patchy lower intensities in the basal ganglia compared to control. There are several paramagnetic substances in brain tissue that could potentially reduce both T2 and T2 * relaxation times, including ferritin, iron (Fe3+), manganese, copper and others. Because iron is most abundant, low intensities on T2 and T2 * weighted images most likely reflect iron deposition. Iron, especially Fe3+, deposition was visible in the pathological specimens stained with Prussian blue after images were obtained. Although radiological-pathological comparisons are not straightforward with respect to either the MRI signal or relaxation quantification, there appears to be a correlation between the relative increase in iron as assessed by Prussian blue staining and the decrease in T2 * value between the DLB and control specimens. As such, this exceptionally high field MRI technique may provide details about the role that iron deposition plays either directly or indirectly as a biomarker in neurodegenerative processes. PMID:21878728

  8. The Neutron Electric Dipole Moment using $N_f{=}2{+}1{+}1$ twisted mass fermions

    Alexandrou, C; Constantinou, M; Hadjiyiannakou, K; Jansen, K; Koutsou, G; Ottnad, K; Petschlies, M

    2015-01-01

    We evaluate the neutron electric dipole moment $\\vert\\vec{d}_N\\vert$ using lattice QCD techniques. The gauge configurations analysed are produced by the European Twisted Mass Collaboration using $N_f{=}2{+}1{+}1$ twisted mass fermions at one value of the lattice spacing of $a \\simeq 0.082 \\ {\\rm fm}$ and a light quark mass corresponding to $m_{\\pi} \\simeq 373 \\ {\\rm MeV}$. Our approach to extract the neutron electric dipole moment is based on the calculation of the $CP$-odd electromagnetic form factor $F_3(Q^2)$ for small values of the vacuum angle $\\theta$ in the limit of zero Euclidean momentum transfer $Q^2$. The limit $Q^2 \\to 0$ is realised either by adopting a parameterization of the momentum dependence of $F_3(Q^2)$ and performing a fit, or by employing new position space methods, which involve the elimination of the kinematical momentum factor in front of $F_3(Q^2)$. The computation in the presence of a $CP$-violating term requires the evaluation of the topological charge ${\\cal Q}$. This is computed ...

  9. Axial, Scalar and Tensor Charges of the Nucleon from 2+1+1-flavor Lattice QCD

    Bhattacharya, Tanmoy; Cohen, Saul; Gupta, Rajan; Lin, Huey-Wen; Yoon, Boram

    2016-01-01

    We present results for the isovector axial, scalar and tensor charges $g^{u-d}_A$, $g^{u-d}_S$ and $g^{u-d}_T$ of the nucleon needed to probe the Standard Model and novel physics. The axial charge is a fundamental parameter describing the weak interactions of nucleons. The scalar and tensor charges probe novel interactions at the TeV scale in neutron and nuclear $\\beta$-decays, and the flavor-diagonal tensor charges $g^{u}_T$, $g^{d}_T$ and $g^{s}_T$ are needed to quantify the contribution of the quark electric dipole moment (EDM) to the neutron EDM. The lattice-QCD calculations were done using nine ensembles of gauge configurations generated by the MILC Collaboration using the HISQ action with 2+1+1 dynamical flavors. These ensembles span three lattice spacings $a \\approx 0.06, 0.09$ and $0.12$ fm and light-quark masses corresponding to the pion masses $M_\\pi \\approx$ 135, 225 and 315 MeV. High-statistics estimates on five ensembles using the all-mode-averaging method allow us to quantify all systematic unce...

  10. The near-infrared excitation of the HH 211 protostellar outflow

    O'Connell, B.; Smith, M. D.; Froebrich, D.; Davis, C. J.; Eislöffel, J.

    2005-02-01

    The protostellar outflow HH 211 is of considerable interest since it is extremely young and highly collimated. Here, we explore the outflow through imaging and spectroscopy in the near-infrared to determine if there are further diagnostic signatures of youth. We confirm the detection of a near-infrared continuum of unknown origin. We propose that it is emitted by the driving millimeter source, escapes the core through tunnels, and illuminates features aligning the outflow. Narrow-band flux measurements of these features contain an unusually large amount of continuum emission. [FeII] emission at 1.644 μm has been detected and is restricted to isolated condensations. However, the characteristics of vibrational excitation of molecular hydrogen resemble those of older molecular outflows. We attempt to model the ordered structure of the western outflow as a series of shocks, finding that bow shocks with J-type dissociative apices and C-type flanks are consistent. Moreover, essentially the same conditions are predicted for all three bows except for a systematic reduction in speed and density with distance from the driving source. We find increased K-band extinctions in the bright regions as high as 2.9 mag and suggest that the bow shocks become visible where the outflow impacts on dense clumps of cloud material. We propose that the outflow is carved out by episodes of pulsating jets. The jets, driven by central explosive events, are responsible for excavating a central tunnel through which radiation temporarily penetrates. Based in part on observations collected at the German-Spanish Astronomical Center, Calar Alto, operated jointly by Max-Planck Institut für Astronomie and Instituto de Astrofísica de Andalucía (CSIC). Observations were also obtained with The United Kingdom Infrared Telescope, which is operated by the Joint Astronomy Centre on behalf of the UK Particle Physics and Astronomy Research Council.

  11. Fabrication of YBCO film approached by the '211 process' in the TFA-MOD method

    We fabricated YBCO film using a new approach to the TFA-MOD method. In the fabrication process, Y2Ba1Cu1Ox and Ba3Cu5O8 powders were used as precursors (the so called '211 process'), instead of Y-, Ba-, and Cu-based acetates, and dissolved in trifluoroacetic acid followed by calcining and firing heat treatment. Consequently, we successfully synthesized YBCO film and evaluated the phase formation, texture evolution, and critical properties as a function of the calcining and firing temperature and humidity, in order to explore its possible application in coated conductor fabrication. The films were calcined at 430-460 deg. C and then fired at 750-800 deg. C in a 0-20% humidified Ar-O2 atmosphere. We observed that the amount of BaF2 phase was effectively reduced and that a sharp and strong biaxial texture formed under a humidified atmosphere, leading to increased critical properties. In addition, we found that the microstructure varied significantly with the firing temperature; the grains grew further, the film became denser, and the degree of texture and phase purity varied as the firing temperature increased. For the film fired at 775 deg. C after calcining at 460 deg. C, the critical current was found to be 39 A cm-1 width (the corresponding critical current density is 2.0 MA cm-2), which was probably attributable to such factors as the enhanced phase purity and out-of-plane texture, the moderate film density and grain size, and the crack-free surface

  12. Project Management Plan for Initial Tank Retrieval Systems, Project W-211

    Project W-211, Initial Tank Retrieval Systems (ITRS), is a fiscal year 1994 Major Systems Acquisition that will provide systems for retrieval of radioactive wastes from selected double-shell tanks (DST). The contents of these tanks are a combination of supernatant liquids and settled solids. To retrieve waste from the tanks, it is first necessary to mix the liquid and solids prior to transferring the slurry to alternative storage or treatment facilities. The ITRS will provide systems to mobilize the settled solids and transfer the wastes out of the tanks. In so doing, ITRS provides feed for future processing plants, allows for consolidation of tank solids to manage space within existing DST storage capacity, and supports continued safe storage of tank waste. The ITRS scope has been revised to include waste retrieval systems for tanks AP-102, AP-104, AP-108, AN-103, AN-104, AN-105, AY-102, AZ-102, and SY-102. This current tank selection and sequence provides retrieval systems supporting the Privatized waste processing plant and sustains the ability to provide final remediation of several watch list DSTs via treatment. The ITRS is configured to support changing program needs, as constrained by available budget, by maintaining the flexibility for exchanging tanks requiring mixer pump-based retrieval systems and shifting the retrieval sequence. Preliminary design was configured such that an adequate basis exists for initiating Title II design of a mixer pump based retrieval system for any DST. This Project Management Plan (PMP) documents the methodology for managing the ITRS, formalizes organizational responsibilities and interfaces, and identifies project requirements such as change control, design verification, systems engineering, and human factors engineering

  13. Diagnostic Significance of Combining Telomerase Activity with CYFRA21-1 Level in Differentiating Malignant Pleural Effusion Caused by Lung Cancer from Benign Pleural Effusio

    Hongmei LI

    2010-06-01

    Full Text Available Background and objective Telomerase and CYFRA21-1 may be positively expressed in malignant pleural effusion, but the sensitivity and specificity of single tumor marker were low. The aim of this study is to investigate the diagnostic value of combining determination of telomerase activity and CYFRA21-1 levels in differentiating benign from malignant pleural effusion caused by lung cancer. Methods 80 patients with malignant and 50 patients with benign pleural effusion were enrolled into this study. The telomerase activity in pleural effusion was tested by means of telomeric repeat amplification protocal-PCR-ELISA (TRAP-PCR-ELISA and CYFRA21-1 levels were tested by the EIA method. All the results were analyzed by the statistical method. Results The levels of telomerase and CYFRA21-1 in malignant pleural effusion was significantly higher than that in benign one (t =17.252 and t =13.951, P<0.001. The sensitivity of telomerase activity testing for diagnosing malignant pleural effusion was 71.3%; the specificity was 86.0% and the overall accuracy was 76.9%. The sensitivity of CYFRA 21-1 testing was 60.0%, the specificity was 78.0% and the overall accuracy was 66.9%. The sensitivity of the combined testing was 90.0%, the specificity was 76.0% and the overall accuracy was 86.9%. The sensitivity and the overall accuracy of combined testing were higher than those of telomerase and CYFRA21-1 testing single(χ2=9.002 and χ2=19.201, P<0.01; χ2=4.389 and χ2=14.647, P<0.05. Conclusion The combined testing of telomerase with CYFRA21-1 can increase the sensitivity and overall accuracy of differential diagnosis of benign and malignant pleural effusion diagnosis.

  14. Clinical value of CEA and CYFRA 21-1 for the differentiation of benign and malignant pleural effusion by Meta analysis

    Objective: Pleural effusion is a common clinical complication caused by many benign or malignant diseases. Many published papers presented that tumor-marker assays, such as carcinoembryonic antigen (CEA) and cytokeratin 19 fragment antigen 21-1 (CYFRA 21-1), played a vital role on the benign and malignant differentiation. This study aimed to reviewe currently available published papers to evaluate the clinical value of these two markers for the differentiation of benign and malignant pleural effusion. Methods: All published data of pleural effusion CEA and CYFRA 21-1 for the differentiation studies from year 1996 to 2007 were reviewed. By methodological qualities and Q test, 19 papers were selected into this study. The overall diagnostic sensitivity, specificity, and area under curve (AUC) from receiver operating characteristic (ROC) curve were adopted to compare the value of pleural effusion CEA and CYFRA 21-1 for benign and malignant differentiation used Z test. Results: There were 3228 subjects included in this Meta-analysis. The sensitivity and specificity [95% confidence interval (CI)] of CEA were 45.9% (43.2%-48.5%) and 97.0% (96.0%-97.8%), and of CYFRA 21-1, 47.3% (44.0%-50.6%) and 91.8% (89.5%-93.7%). AUC of CEA and CYFRA 21-1 were 0.7691 and 0.8213 respectively (Z=0.45, P>0.05). Conclusion: Both CEA and CYFRA 21-1 are useful for the differentiation of benign and malignant pleural effusion. (authors)

  15. AVN-211, Novel and Highly Selective 5-HT6 Receptor Small Molecule Antagonist, for the Treatment of Alzheimer's Disease.

    Ivachtchenko, Alexandre V; Lavrovsky, Yan; Ivanenkov, Yan A

    2016-03-01

    Within the past decade several novel targets have been indicated as key players in Alzheimer-type dementia and associated conditions, including a "frightening" memory loss as well as severe cognitive impairments. These proteins are deeply implicated in crucial cell processes, e.g., autophagy, growth and progression, apoptosis, and metabolic equilibrium. Since recently, 5-HT6R has been considered as one of the most prominent biological targets in AD drug therapy. Therefore, we investigated the potential procognitive and neuroprotective effects of our novel selective 5-HT6R antagonist, AVN-211. During an extensive preclinical evaluation the lead compound demonstrated a relatively high therapeutic potential and improved selectivity toward 5-HT6R as compared to reference drug candidates. It was thoroughly examined in different in vivo behavioral models directly related to AD and showed evident improvements in cognition and learning. In many cases, the observed effect was considerably greater than that determined for the reported drugs and drug candidates, including memantine, SB-742457, and Lu AE58054, evaluated under the same conditions. In addition, AVN-211 showed a similar or better anxiolytic efficacy than fenobam, rufinamide, lorazepam, and buspirone in an elevated plus-maze model, elevated platform, and open field tests. The compound demonstrated low toxicity and no side effects in vivo, an appropriate pharmacokinetic profile, and stability. In conclusion, AVN-211 significantly delayed or partially halted the progressive decline in memory function associated with AD, which makes it an interesting drug candidate for the treatment of neurodegenerative and psychiatric disorders. Advanced clinical trials are currently under active discussion and in high priority. PMID:26886442

  16. South-East Asia bovine populations and the Japanese cattle breeds do not harbour the E211K variant of the PRNP

    George Msalya

    2014-02-01

    Full Text Available An important outcome of intensive worldwide Bovine spongiform encephalopathy (BSE obtained with the surveillance by The National Creutzfeldt-Jakob Disease Surveillance Unit (http://www.cjd.ed.ac.uk/figures. htm, has been the detection of atypical BSE in cattle. The discovery of a prion protein gene (PRNP E211K variant in an atypical BSE case is particularly remarkable because it is analogous to the most common pathogenic mutation in humans (E200K, which causes hereditary Creutzfeldt-Jakob disease (CJD. Knowledge of the distribution and frequency of PRNP E211K variants in cattle populations is critical for understanding and managing atypical BSE. This study was carried out to investigate the prevalence of the E211K variant in the South-East Asia bovine populations and in the Japanese cattle breeds. It was discovered that E211K variant was monomorphic for a G allele and the GG genotype in the 745 animals analyzed in this study. Therefore, neither the Bos indicus nor the Bos taurus animals analyzed are presently known to harbor the 211K variant predicting that the number of carriers for this variant will also be vanishingly low.

  17. Clinical significance of determination of changes of serum contents of CYFRA21-1, IL-2, TNF-α and TGF-β in patients with nasopharyngeal carcinoma

    Objective: To investigate the clinical significance of determination of changes of serum contents of CYFRA21-1, IL -2, TNF-α and TGF-β in patients with nasopharyngeal carcinoma. Methods: Serum levels of CYFRA21-1, IL-2, TNF-α and TGF-β were determined with radioimmunoassay in 30 patients with nasopharyngeal carcinoma both before and after treatment as well as in 30 controls. Results: Before therapy (synchronous chemo and radio therapy) serum levels of CYFRA21-1, TNF-α and TGF-β were significantly higher (P 0.05) in patients from those in controls, however, serum levels of TGF-β, TNF-α and IL-8 were still significantly higher (P< 0.05) than those in controls. Conclusion: Changes of CYFRA21-1, CYFRA21-1, IL-2, TNF-α and TGF-β levels were closely related to the disease process of nasopharyngeal carcinoma. Determination of changes of these markers might be helpful for clinical diagnosis and outcome prediction. (authors)

  18. Clinical significance of combined detection of CYFRA21-1, NSE and CEA in classification and staging of patients with lung cancer

    To explore clinical value of combined detection of CYFRA21-1, NSE and CEA in classification and staging of patients with lung cancer, the CYFRA21-1, NSE and CEA levels in pleural effusion in 330 patients with lung cancer and in 43 patients with benign were detected by the electrochemiluminescence. The results showed that CYFRA21-1, NSE and CEA levels in pleural effusion in patients with lung cancer group were significantly higher than that of in benign group (P<0.01). The positive rate of tumor markers in different pathological type lung cancer were different,which CYFRA21-1 positive rate in squamous cell cancer group was highest with 65.5%; CEA positive rate in glands cancer group was supreme with 65.0%; the NSE positive rate in differentiation cancer group was highest with 79.5%. The positive rate in three markers combined detection was higher than that in one item detection. The tumor marker levels in lung cancer were positively related with clinical staging. The higher of tumor marker levels and the more late of clinical staging, and the clinical III∼IV period was obviously higher than that I∼II period (P<0.05). The combined detection of CYFRA21-1, NSE and CEA may enhance the positive rate in lung cancer detection, and may have significant clinical value in the classification and staging of patients with lung cancer. (authors)

  19. Computing K and D meson masses with N{sub f}=2+1+1 twisted mass lattice QCD

    Baron, Remi [CEA, Centre de Saclay, 91 - Gif-sur-Yvette (France). IRFU/Service de Physique Nucleaire; Blossier, Benoit; Boucaud, Philippe [Paris XI Univ., 91 - Orsay (FR). Lab. de Physique Theorique] (and others)

    2010-05-15

    We discuss the computation of the mass of the K and D mesons within the framework of N{sub f}=2+1+1 twisted mass lattice QCD from a technical point of view. These quantities are essential, already at the level of generating gauge configurations, being obvious candidates to tune the strange and charm quark masses to their physical values. In particular, we address the problems related to the twisted mass flavor and parity symmetry breaking, which arise when considering a non-degenerate (c,s) doublet. We propose and verify the consistency of three methods to extract the K and D meson masses in this framework. (orig.)

  20. Measurement of cytokeratin 19 fragments as a marker of lung cancer by CYFRA 21-1 enzyme immunoassay.

    Takada, M; Masuda, N.; Matsuura, E.; Kusunoki, Y; Matui, K.; Nakagawa, K.; Yana, T.; Tuyuguchi, I.; Oohata, I.; Fukuoka, M

    1995-01-01

    Soluble cytokeratin fragment 19 levels were measured with an enzyme immunoassay method developed by Boehringer Mannheim (Enzymun-Test CYFRA 21-1) in the serum of 185 patients with lung cancer [149 with non-small-cell lung cancer (NSCLC) and 36 with small-cell lung cancer (SCLC)] and 97 patients with benign lung diseases in order to determine its clinical usefulness in the diagnosis of lung cancer and follow-up of treatment. We used the cut-off value of 3.5 ng ml-1, established by the Japan CY...

  1. Computing K and D meson masses with N_f = 2+1+1 twisted mass lattice QCD

    Baron, Remi; Carbonell, Jaume; Drach, Vincent; Farchioni, Federico; Herdoiza, Gregorio; Jansen, Karl; Michael, Chris; Montvay, Istvan; Pallante, Elisabetta; Pene, Olivier; Reker, Siebren; Urbach, Carsten; Wagner, Marc; Wenger, Urs

    2010-01-01

    We discuss the computation of the mass of the K and D mesons within the framework of N_f = 2+1+1 twisted mass lattice QCD from a technical point of view. These quantities are essential, already at the level of generating gauge configurations, being obvious candidates to tune the strange and charm quark masses to their physical values. In particular, we address the problems related to the twisted mass flavor and parity symmetry breaking, which arise when considering a non-degenerate (c,s) doublet. We propose and verify the consistency of three methods to extract the K and D meson masses in this framework.

  2. 联合检测血清Cyfra 21-1、CK19-2G2在非小细胞肺癌患者中的诊断%Clinical diagnostic value of combined detection of serum Cyfra 21-1 and CK19-2G2 in patients with non-small cell lung cancer

    廖长征; 徐文莉; 魏晟潇; 许瑞环; 刘紫菱; 罗艺

    2014-01-01

    目的::探讨联合检测血清Cyfra 21-1、CK19-2G2在非小细胞肺癌患者中的诊断。方法:采用化学发光免疫法检测92例非小细胞肺癌患者、83例肺部良性疾病患者和90例健康体检者血清Cyfra 21-1、CK19-2G2的浓度,并判断两者的相关性。比较单独与联合检测Cyfra21-1、CK19-2G2对于诊断非小细胞肺癌的灵敏度和特异性。结果:非小细胞肺癌组血清Cyfra 21-1、CK19-2G2水平显著高于肺部良性疾病组和健康对照组( P<0.01);非小细胞肺癌患者血清Cyfra 21-1与CK19-2G2水平呈正相关性( P<0.05)。两者联合诊断非小细胞肺癌的灵敏度为82.7%、特异性为78%。结论:Cyfra 21-1、CK19-2G2是有效的诊断非小细胞肺癌的肿瘤标志物。血清Cyfra 21-1、CK19-2G2水平在非小细胞肺癌的诊断中有临床应用价值,两者联合检测的灵敏度和特异性高。%Objective:To investigate the clinical diagnostic value of the combined detection of serum Cyfra 21-1 and CK19-2G2 in patients with the non-small cell lung cancer ( NSCLC ) . Methods:The levels of serum Cyfra 21-1 and CK19-2G2 in 92 cases of NSCLC,83 of benign lung diseases and 90 of healthy controls were detected by chemiluminescent immunoassay. And the correlation between Cyfra 21-1 and CK19-2G2 was evaluated.Moreover,the sensitivity and specificity of combined detection of serum Cyfra 21-1 and CK19-2G2 for of the diagnosis of the NSCLC was compared with detection of either alone.Results:The Cyfra 21-1 and CK19-2G2 levels in serum of the NSCLC patients were significantly higher than those with benign lung disease and healthy controls (P<0.01).The Cyfra 21-1 and CK19-2G2 levels of the NSCLC patients were positively correlated (P<0. 05).Combined detection of both biomarkers in NSCLC yielded a sensitivity of 82.7% and a specificity of 78%. Conclusions:Cyfra 21-1 and CK19-2G2 are effective tumor markers for the diagnosis of NSCLC. With high sensitivity and specificity of

  3. Clinical significance of combined determination of several tumor markers (including CYFRA21-1, NSE, CA-50 and CEA) in patients with pulmonary cancer

    Objective: To enhance the diagnosis of pulmonary cancer by determination of optimal combinations of various tumor markers. Methods: Serum CYFRA21-1, NSE, CA-50 (with RIA) and CEA (with CLIA) contents were determined in 107 patients with various types of pulmonary cancers, 66 patients with various benign pulmonary diseases and 59 controls. Results: It was revealed that CYFRA21-1 determination was most sensitive for detection of squamous cell carcinoma. The same was true for CEA in the detection of adenocarcinoma. NSE determination was very specific for small cell carcinoma. Combined determinations of either CYFRA21-l + NSE or CYFRA21-1 + NSE + CEA were excellent for general screening. Conclusion: Combined determination of these tumor markers could be applied expediently as supplementary diagnostic measure for pulmonary malignancies. (authors)

  4. Transcriptional Response in Mouse Thyroid Tissue after 211At Administration: Effects of Absorbed Dose, Initial Dose-Rate and Time after Administration.

    Nils Rudqvist

    Full Text Available 211At-labeled radiopharmaceuticals are potentially useful for tumor therapy. However, a limitation has been the preferential accumulation of released 211At in the thyroid gland, which is a critical organ for such therapy. The aim of this study was to determine the effect of absorbed dose, dose-rate, and time after 211At exposure on genome-wide transcriptional expression in mouse thyroid gland.BALB/c mice were i.v. injected with 1.7, 7.5 or 100 kBq 211At. Animals injected with 1.7 kBq were killed after 1, 6, or 168 h with mean thyroid absorbed doses of 0.023, 0.32, and 1.8 Gy, respectively. Animals injected with 7.5 and 100 kBq were killed after 6 and 1 h, respectively; mean thyroid absorbed dose was 1.4 Gy. Total RNA was extracted from pooled thyroids and the Illumina RNA microarray platform was used to determine mRNA levels. Differentially expressed transcripts and enriched GO terms were determined with adjusted p-value 1.5, and p-value <0.05, respectively.In total, 1232 differentially expressed transcripts were detected after 211At administration, demonstrating a profound effect on gene regulation. The number of regulated transcripts increased with higher initial dose-rate/absorbed dose at 1 or 6 h. However, the number of regulated transcripts decreased with mean absorbed dose/time after 1.7 kBq 211At administration. Furthermore, similar regulation profiles were seen for groups administered 1.7 kBq. Interestingly, few previously proposed radiation responsive genes were detected in the present study. Regulation of immunological processes were prevalent at 1, 6, and 168 h after 1.7 kBq administration (0.023, 0.32, 1.8 Gy.

  5. Surface roughness estimation of MBE grown CdTe/GaAs(211)B by ex-situ spectroscopic ellipsometry

    Karakaya, Merve; Bilgilisoy, Elif; Arı, Ozan; Selamet, Yusuf

    2016-07-01

    Spectroscopic ellipsometry (SE) ranging from 1.24 eV to 5.05 eV is used to obtain the film thickness and optical properties of high index (211) CdTe films. A three-layer optical model (oxide/CdTe/GaAs) was chosen for the ex-situ ellipsometric data analysis. Surface roughness cannot be determined by the optical model if oxide is included. We show that roughness can be accurately estimated, without any optical model, by utilizing the correlation between SE data (namely the imaginary part of the dielectric function, or phase angle, ψ) and atomic force microscopy (AFM) roughness. and ψ values at 3.31 eV, which corresponds to E1 critical transition energy of CdTe band structure, are chosen for the correlation since E1 gives higher resolution than the other critical transition energies. On the other hand, due to the anisotropic characteristic of (211) oriented CdTe surfaces, SE data ( and ψ) shows varieties for different azimuthal angle measurements. For this reason, in order to estimate the surface roughness by considering these correlations, it is shown that SE measurements need to be taken at the same surface azimuthal angle. Estimating surface roughness in this manner is an accurate way to eliminate cumbersome surface roughness measurement by AFM.

  6. A Multi-Epoch SMA Study of the HH 211 Protostellar Jet: Jet Motion and Knot Formation

    Jhan, Kai-Syun

    2015-01-01

    HH 211 is a highly collimated jet with a chain of well-defined knots, powered by a nearby young Class 0 protostar. We have used 4 epochs (2004, 2008, 2010, and 2013) of Submillimeter Array (SMA) archive data to study the properties of the HH 211 jet in SiO (J=8-7). The jet shows similar reflection-symmetric wiggle structures in all epochs. The wiggle structures can all be fitted by an orbiting jet source model that includes a position shift due to proper motion of the jet, indicating that the wiggle propagates along the jet axis. Thus, this suggests the wiggle is indeed due to an orbital motion of the jet source. Proper motions of the knots are measured by using the peak positions of the knots in four epochs, and they are roughly the same and independent of the distance from the central source. The mean proper motion of the knots is $\\sim$ 0.087 arcsec per year, resulting in a transverse velocity of $\\sim$ 114 km s$^{-1}$, about 30\\% lower than that measured before. Knots BK2 and BK3 have a well-defined linea...

  7. Development and radiotherapeutic application of 211At-labeled radiopharmaceuticals. Progress report, March 1, 1981-February 28, 1982

    This project is concerned with developing the potential of alpha-emitting radionuclides as agents for radiotherapy. Alpha-emitters seem ideally suited for his application because their high linear energy transfer and short range permit the deposition of considerable energy in a very small volume of tissue. Unlike the beta particles of 131I which have a range of about 1 to 2 mm in tissue, 5 to 7 MeV alpha particles would traverse only a few cell diameters. Among the available alpha-emitters, 211At appears most promising for therapeutic applications because, (1) it has some chemical similarities to iodine, an element that can readily be incorporated into numerous proteins and peptides, (2) it has a half-life that is long enough to permit chemical manipulation yet short enough to minimize destruction of healthy cells due to degradation of the label over time, (3) it can be produced conveniently using a cyclotron, and (4) alpha emission is associated with 100% of its decays with no accompanying beta emission. In the past year the evaluation of an astatine-tellurium colloid as an agent for the destruction of malignant ascites has been completed. The therapeutic efficacy of 211At-tellurium colloid has been compared with that of several beta-emitting radiocolloids. Studies on the application of monoclonal antibodies as carriers for selective delineation and destruction of malignant cell populations have also been initiated

  8. Time-resolved multiwavelength observations of the blazar VER J0521+211 from radio to gamma-ray energies

    Prokoph, Heike; Schultz, Cornelia

    2015-01-01

    VER J0521+211 (RGB J0521.8+2112) is one of the brightest and most powerful blazars detected in the TeV gamma-ray regime. It is located at a redshift of z=0.108 and since its discovery in 2009, VER J0521+211 has exhibited an average TeV flux exceeding 0.1 times that of the Crab Nebula, corresponding to an isotropic luminosity of $3\\times10^{44}$ erg s$^{-1}$. We present data from a comprehensive multiwavelength campaign on this object extending between November 2012 and February 2014, including single-dish radio observations, optical photometry and polarimetry, UV, X-ray, GeV and TeV gamma-ray data (VERITAS, MAGIC). Significant flux variability was observed at all wavelengths, including a long-lasting high state at gamma-ray energies in Fall 2013. Nightly-resolved spectra at X-ray and TeV energies are be presented, and emission mechanisms explaining the observed flux and spectral variability are discussed.

  9. Gamma-ray flaring activity from the gravitationally lensed blazar PKS 1830-211 observed by Fermi LAT

    Abdo, A A; Ajello, M; Allafort, A; Amin, M A; Baldini, L; Barbiellini, G; Bastieri, D; Bechtol, K; Bellazzini, R; Blandford, R D; Bonamente, E; Borgland, A W; Bregeon, J; Brigida, M; Buehler, R; Bulmash, D; Buson, S; Caliandro, G A; Cameron, R A; Caraveo, P A; Cavazzuti, E; Cecchi, C; Charles, E; Cheung, C C; Chiang, J; Chiaro, G; Ciprini, S; Claus, R; Cohen-Tanugi, J; Conrad, J; Corbet, R H D; Cutini, S; D'Ammando, F; de Angelis, A; de Palma, F; Dermer, C D; Drell, P S; Drlica-Wagner, A; Favuzzi, C; Finke, J; Focke, W B; Fukazawa, Y; Fusco, P; Gargano, F; Gasparrini, D; Gehrels, N; Giglietto, N; Giordano, F; Giroletti, M; Glanzman, T; Grenier, I A; Grove, J E; Guiriec, S; Hadasch, D; Hayashida, M; Hays, E; Hughes, R E; Inoue, Y; Jackson, M S; Jogler, T; Jòhannesson, G; Johnson, A S; Kamae, T; Knödlseder, J; Kuss, M; Lande, J; Larsson, S; Latronico, L; Longo, F; Loparco, F; Lott, B; Lovellette, M N; Lubrano, P; Madejski, G M; Mazziotta, M N; Mehault, J; Michelson, P F; Mizuno, T; Monzani, M E; Morselli, A; Moskalenko, I V; Murgia, S; Nemmen, R; Nuss, E; Ohno, M; Ohsugi, T; Paneque, D; Perkins, J S; Pesce-Rollins, M; Piron, F; Pivato, G; Porter, T A; Rainò, S; Rando, R; Razzano, M; Reimer, A; Reimer, O; Reyes, L C; Ritz, S; Romoli, C; Roth, M; Parkinson, P M Saz; Sgrò, C; Siskind, E J; Spandre, G; Spinelli, P; Takahashi, H; Takeuchi, Y; Tanaka, T; Thayer, J G; Thayer, J B; Thompson, D J; Tibaldo, L; Tinivella, M; Torres, D F; Tosti, G; Troja, E; Tronconi, V; Usher, T L; Vandenbroucke, J; Vasileiou, V; Vianello, G; Vitale, V; Waite, A P; Werner, M; Winer, B L; Wood, K S

    2014-01-01

    The Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope routinely detects the highly dust-absorbed, reddened, and MeV-peaked flat spectrum radio quasar PKS 1830-211 (z=2.507). Its apparent isotropic gamma-ray luminosity (E>100 MeV) averaged over $\\sim$ 3 years of observations and peaking on 2010 October 14/15 at 2.9 X 10^{50} erg s^{-1}, makes it among the brightest high-redshift Fermi blazars. No published model with a single lens can account for all of the observed characteristics of this complex system. Based on radio observations, one expects time delayed variability to follow about 25 days after a primary flare, with flux about a factor 1.5 less. Two large gamma-ray flares of PKS 1830-211 have been detected by the LAT in the considered period and no substantial evidence for such a delayed activity was found. This allows us to place a lower limit of about 6 on the gamma rays flux ratio between the two lensed images. Swift XRT observations from a dedicated Target of Opportunity program ...

  10. Piezoelectric InAs (211)B quantum dots grown by molecular beam epitaxy: Structural and optical properties

    The structural and optical properties of piezoelectric (211)B InAs nanostructures grown by molecular beam epitaxy are systematically investigated as a function of the various growth parameters. Depending on the specific growth conditions, we show that the InAs nanostructures take the form of a quantum dot (QD) or a quantum dash, their height ranges between 2 and 20 nm, and their density varies from a few times 108 cm-2 all the way up to a few times 1010 cm-2. The (211)B QDs are characterized by large aspect ratios, which are compatible with a truncated pyramid morphology. By analyzing the QD emission spectrum, we conclude that only small size QDs, with heights less than 3 nm, are optically active. This is consistent with high resolution transmission electron microscopy observations showing that large QDs contain misfit dislocations, whereas small QDs are dislocation-free. The formation of a two-dimensional wetting layer is observed optically, and its thickness is determined to be between 0.30 and 0.39 nm. Finally, the large blueshift in the QD emission observed with increasing excitation power represents a clear evidence of the strong built-in piezoelectric field present in these dots.

  11. Disease monitoring by the tumour maskers Cyfra 21.1 and TPA in patients with non-small cell lung cancer

    van der Gaast, Ate; Kok, Tjebbe; Kho, Marcia; Blijenberg, Bert; Splinter, Ted

    1995-01-01

    textabstractWe evaluated the use of two tumour markers Cyfra 21.1 and tissue polypeptide antigen (TPA) for disease monitoring. Assessment of response to WHO criteria was compared to response assessment according to changes in the tumour marker levels. The criteria defined for marker response were a 65% decrease for a partial response and a 40% increase for progressive disease. When response evaluations with a positive lead time were included, 72% of 115 evaluations for Cyfra 21.1 and 59% of 1...

  12. Fine-Needle Aspirates CYFRA 21-1 is a Useful Tumor Marker for Detecting Axillary Lymph Node Metastasis in Breast Cancer Patients

    Jung Hyun Yoon; Kyung Hwa Han; Eun-Kyung Kim; Hee Jung Moon; Min Jung Kim; Young Joo Suh; Ji Soo Choi; Byeong-Woo Park

    2013-01-01

    INTRODUCTION: To assess whether the value of CYFRA21-1 in the aspirates of ultrasonography-guided fine-needle aspiration biopsy (US-FNAB) can contribute to improving the performances of US-FNAB in the diagnosis of axillary lymph node (LN) metastasis in breast cancer patients. METHODS: US-FNAB was performed in 156 axillary LNs in 152 breast cancer patients (mean age: 51.4 years, range: 17-92 years). Concentrations of CYFRA21-1 were measured from washouts of the syringe used during US-FNAB. Tum...

  13. Fine-needle aspirates CYFRA 21-1 is a useful tumor marker for detecting axillary lymph node metastasis in breast cancer patients.

    Jung Hyun Yoon

    Full Text Available INTRODUCTION: To assess whether the value of CYFRA21-1 in the aspirates of ultrasonography-guided fine-needle aspiration biopsy (US-FNAB can contribute to improving the performances of US-FNAB in the diagnosis of axillary lymph node (LN metastasis in breast cancer patients. METHODS: US-FNAB was performed in 156 axillary LNs in 152 breast cancer patients (mean age: 51.4 years, range: 17-92 years. Concentrations of CYFRA21-1 were measured from washouts of the syringe used during US-FNAB. Tumor marker concentrations, US-FNAB, intraoperative sentinel node biopsy (SNB, and surgical pathology results were reviewed and analyzed. For comparison, the values of CEA and CA15-3 were also measured from washouts. RESULTS: Among the 156 LNs, 75 (48.1% were benign, and 81 (51.9% were metastases. Mean concentrations of CYFRA21-1 were significantly higher in metastasis compared to benign LNs (P<0.001. US-FNAB combined to CYFRA21-1 showed significantly higher sensitivity, NPV, and accuracy compared to US-FNAB alone (all values P<0.05. All diagnostic indices of US-FNAB combined to CYFRA21-1 were significantly higher compared to US-FNAB combined with CEA or CA15-3 (all P<0.001. Of the 28 metastatic LNs which showed metastasis on SNB, CYFRA21-1 showed higher positive rate of 75.0% (CEA or CA15-3∶60.7%, P = 0.076. CONCLUSION: Measuring CYFRA 21-1 concentrations from US-FNAB aspirates improves sensitivity, NPV, and accuracy of US-FNAB alone, and may contribute to reducing up to 75.0% of unnecessary intraoperative SNB. Compared to CEA or CA15-3, CYFRA21-1 shows significantly higher performances when combined to US-FNAB in the preoperative diagnosis of LN metastasis in breast cancer patients.

  14. Preoperative CYFRA 21-1 and CEA as Prognostic Factors in Patients with Stage I Non-Small Cell Lung Cancer

    Blankenburg, Florian; Hatz, Rudolf; Nagel, Dorothea; Ankerst, Donna Pauler; Reinmiedl, Judith; Gruber, Christine; Seidel, Dietrich; Stieber, Petra

    2008-01-01

    Objective: To validate the prognostic value of preoperative levels of CYFRA 21-1, CEA and the corresponding tumor marker index (TMI) in patients with stage I non-small cell lung cancer (NSCLC). Methods: Two hundred forty stage I NSCLC patients (80 in pT1 and 160 in pT2; 100 squamous cell carcinomas, 91 adenocarcinomas, 32 large-cell carcinomas, 17 with other histologies; 171 males and 69 females) who had complete resection (R0) between 1986 and 2004 were included in the analysis. CYFRA 21-1 a...

  15. The prognostic value of the tumour marker Cyfra 21-1 in carcinoma of head and neck and its role in early detection of recurrent disease

    Doweck, I; Barak, M; Uri, N; Greenberg, E

    2000-01-01

    This study examines a new tumour marker, Cyfra 21-1, as a prognostic marker in predicting the survival of H&N cancer patients, and its correlation with clinical outcome during prolonged follow up of these patients. The study included 67 patients with primary detection of carcinoma of H&N. The survival of these patients was evaluated in correlation with the disease stage and Cyfra 21-1 levels at initial diagnosis. 38 patients were followed clinically and with serial assays for at least 12 mont...

  16. Diagnostic values of serum tumor markers Cyfra21-1, SCCAg, ferritin, CEA, CA19-9, and AFP in oral/oropharyngeal squamous cell carcinoma

    Yuan, Chuanshu; Yang, Kai; Tang, Hong; Chen, Dan

    2016-01-01

    Background At present, the research on serum tumor markers in the early diagnosis of malignant tumors has aroused widespread concern. The aim of this study was to investigate the diagnostic values of serum tumor markers cytokeratin 19 fragment (Cyfra21-1), squamous cell carcinoma antigen (SCCAg), ferritin, carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and α-fetoprotein (AFP) for patients with oral/oropharyngeal squamous carcinoma (OSCC/OPSCC). Methods One hundred and sixty-nine cases of patients with OSCC/OPSCC as the experimental group, 86 cases of oral benign tumor patients as the control group, and 30 cases of healthy people as the normal control group were studied. The levels of serum Cyfra21-1, SCCAg, ferritin, CEA, CA19-9, and AFP were measured using electrochemiluminescence immunoassay. Results The levels of serum Cyfra21-1, SCCAg, ferritin, and CEA in patients with OSCC/OPSCC were significantly higher than those of benign tumor and healthy control group (P0.05). The level of serum Cyfra21-1 in patients with early OSCC/OPSCC (stage I + II) was significantly higher than that of benign tumor and healthy control group (P0.05). The levels of serum Cyfra21-1, SCCAg, ferritin, and CEA in the middle-late stage of patients with OSCC/OPSCC (stage III + IV) were significantly higher than those of patients with the early OSCC/OPSCC, benign tumor, and healthy control group (P<0.05). The diagnostic cutoff levels of Cyfra21-1, SCCAg, ferritin, and CEA were 2.17, 0.72, 109.95, and 1.99 ng/mL, respectively. The sensitivities were 60.36%, 73.37%, 81.66%, and 66.27%, respectively. The specificities were 81.03%, 68.10%, 40.52%, and 61.21%, respectively. Conclusion Cyfra21-1, SCCAg, ferritin, and CEA had diagnostic values for patients with OSCC/OPSCC. Meanwhile, Cyfra21-1 had better early diagnostic value for patients with OSCC/OPSCC. PMID:27350753

  17. 血清p53抗体联合CEA、CYFRA21-1检测在肺癌诊断中的价值%Role of combined detection of serum anti-p53 antibody with CEA and CYFRA21-1 in the diagnosis of lung cancer

    杜紫燕; 余勇; 张增利; 李凌云; 邢玉斐; 施敏骅

    2013-01-01

    目的 探讨联合检测肺癌患者血清p53抗体与癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)辅助肺癌诊断的可行性.方法 在57例肺癌(肺癌组)和40例肺部良性疾病患者(对照组),采用ELISA法检测血清p53抗体,采用电化学发光免疫分析法检测血清CEA和CYFRA21-1.结果 肺癌组血清p53抗体、CEA和CYFRA21-1水平均高于对照组(P<0.05).p53抗体、CEA、CYFRA21-1曲线下面积(AUC)分别为0.770、0.814、0.779.p53抗体、CEA和CYFRA21-1的诊断界点分别为1.150 U/ml、3.095 ng/ml、3.240 ng/ml,敏感性分别为45.61%、66.67%、68.42%,特异性分别为87.50%、87.50%、85.00%.三项联合检测的AUC为0.902,敏感性为89.47%,特异性为100%.CEA与CYFAR21-1呈正相关(r=0.555,P<0.05).结论 血清p53抗体为独立的肺癌生物标记物,与CEA、CYFRA21-1联合检测有助于提高肺癌诊断水平.%Objective To explore the value of combined detection of serum anti-p53 antibody with carcinoembryonic antigen(CEA) and CYFRA21-1 in the diagnosis of lung cancer. Methods In 57 patients with lung cancer (group A) and 40 patients with benign pulmonary diseases (group B), serum levels of anti-p53 antibody, CEA and CYFRA 21-1 were measured by ELISA and electro-chemiluminescence immunoassay. Results Serum levels of anti-p53 antibody, CEA and CYFRA21-1 were higher in group A than those in group B(P<0. 05). The values of receiver operating characteristic area under the curve(AUC) for anti-p53 antibody,CEA and CYFRA 21-1 were 0. 770, 0. 814 and 0. 779, respectively. The cutoff levels of anti-p53 antibody, CEA and CYFRA 21-1 were 1. 150 U/ml,3. 095 ng/ml and 3. 240 ng/ml, respectively. The sensitivities of those markers for lung cancer detection were 45. 61%,66. 67%, 68. 42%, while the specificities were 87. 50%, 87. 50% and 85. 00% respectively. The value of AUC, sensitivity and specificity were 0. 90, 89. 47% and 100%, respectively,when combined detection of the three markers was

  18. Clinical value of CEA and CYFRA21-1 for the differentiation of benign and malignant pleural effusion by Meta analysis%CEA和CYFRA 21-1测定鉴别胸腔积液良恶性的Meta分析

    顾平; 陈虞梅; 黄钢; 朱翠英; 袁济民

    2008-01-01

    目的 用Meta分析方法系统评价近10年来癌胚抗原(CEA)和细胞角蛋白19片段抗原21-1(CYFRA 21-1)在鉴别良恶性胸腔积液中的价值,并进一步比较两者在诊断效能上的差异.方法 收集1996年1月-2007年1月间国内外公开发表的关于CEA和CYFRA 21-1鉴别良恶性胸腔积液的文献,对纳入文献进行方法学质量评估后,运用Q检验评价数据的异质性,合并其灵敏度和特异性,用两者综合受试者工作特征(SROC)曲线下面积(AUC)评价和比较(Z检验)CEA和CYFRA 21-1鉴别良恶性胸腔积液的效能.结果 共有19篇文献纳入,研究对象3228例.CEA汇总的灵敏度和特异性[95%可信区间(CI)]为45.9%(43.2%~48.5%)和97.0%(96.0%~97.8%), CYFRA 21-1汇总的灵敏度和特异性(95%CI)为47.3%(44.0%~50.6%)和91.8%(89.5%~93.7%),其结果均存在明显的异质性(P<0.05).CEA和CYFRA 21-1的AUC分别为0.7691和0.8213,Z检验比较两者AUC差异无统计学意义(Z=0.45,P>0.05).结论 CEA和CYFRA 21-1在诊断良恶性胸腔积液时均具有较好的准确性.%Objective Pleural effusion is a common clinical complication caused by many benign or malignant diseases. Many published papers presented that tumor-marker assays, such as carcinoembryonic antigen (CEA) and cytokeratin 19 fragment antigen 21-1 (CYFRA21-1), played a vital role on the benign and malignant differentiation. This study aimed to reviewe currently available published papers to evaluate the clinical value of those two markers for the differentiation of benign and malignant pleural effusion. Methods All published data of pleural effusion CEA and CYFRA21-1 for the differentiation studies from year 1996 to 2007 were reviewed. By methodological qualities and Q test, 19 papers were selected into this study. The overall diagnostic sensitivity, specificity, and area under curve (AUC) from receiver operating characteristic (ROC) curve were adopted to compare the value of pleural effusion CEA and CYFRA21-1 for

  19. Relation between Prognosis and CYFRA21-1 Level in the Peripheral Blood of Patients with Advanced Lung Cancer%外周血CYFRA21-1水平与晚期肺癌预后的关系分析

    张旭峰; 郭志强; 王征

    2015-01-01

    目的 探讨晚期肺癌患者治疗前后外周血CYFRA21-1水平与其预后的关系. 方法 选择晚期肺癌患者148例,采用电化学发光免疫法对所得样本的血清CYFR21-1水平进行检测,将CYFRA21-1水平升高患者纳入高水平组81例,未升高患者纳入低水平组67例. 结果 化疗前与化疗2个周期时,高水平组患者CYFR21-1水平均显著高于低水平组患者,而经过化疗,高水平组患者的CYFR21-1水平明显下降,差异具有统计学意义(P<0.05);并且经过化疗后,低水平组患者的近期治疗有效率以及1年生存率和生存质量评分均显著高于高水平组患者,差异均具有统计学意义(P<0.05). 结论 血清CYFRA21-1的水平可以作为评价晚期非小细胞肺癌患者化疗的疗效指标,也能够对患者的生存期及预后进行评价.%Objective To investigate the relationship between peripheral blood CYFRA21-1 level and prognosis in pa-tients with advanced lung cancer.Methods Serum CYFR21-1 level in 148 advanced lung cancer patients was detected by elec-trochemiluminescence immunoassay,81 cases with elevated CYFRA21-1 was the high level group,67 cases without increase of CYFRA21-1 was the low level group.Results Before chemotherapy and 2 cycles after chemotherapy,CYFR21-1 level of the high level group was significantly higher than that of the low level group,and after chemotherapy,CYFR21-1 level of the high level group decreased significantly,the difference was statistically significant (P<0.05);and after chemotherapy,recent treatment effi-ciency,1-year survival rate and quality of life scores of the low level group were significantly higher than that of the high level group,the differences were statistically significant (P<0.05).Conclusion Serum CYFRA21-1 level could be used as indica-tors of efficacy evaluation of chemotherapy in patients with advanced non-small cell lung cancer,it can also evaluate the survival and prognosis of the patients.

  20. The AtRAD21.1 and AtRAD21.3 Arabidopsis cohesins play a synergistic role in somatic DNA double strand break damage repair

    da Costa-Nunes, J.A.; Capitao, C.; Kozák, Jaroslav; Costa-Nunes, P.; Ducasa, G.M.; Pontes, O.; Angelis, Karel

    2014-01-01

    Roč. 14, DEC 16 2014 (2014). ISSN 1471-2229 R&D Projects: GA MŠk(CZ) LD13006; GA ČR GA13-06595S Institutional support: RVO:61389030 Keywords : Arabidopsis * AtRAD21.1 * AtRAD21.3 Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.813, year: 2014

  1. 76 FR 20229 - Airworthiness Directives; Rolls-Royce plc (RR) RB211-Trent 768-60 and Trent 772-60 Turbofan Engines

    2011-04-12

    ... (63 FR 49416, September 16, 1998). We must receive any comments on this AD by May 27, 2011. ADDRESSES... 39-10754 (63 FR 49416, September 16, 1998), for RR RB211-Trent 700 series turbofan engines. That AD... Policies and Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in...

  2. 49 CFR Appendix A to Part 211 - Statement of Agency Policy Concerning Waivers Related to Shared Use of Trackage or Rights-of-Way...

    2010-10-01

    ... rail equipment does not meet the standards of 49 CFR part 238, you should provide specifics on the... connection. If movements at the crossing are governed by a signal system, FRA's signal rules (49 CFR parts...”) under the provisions of 49 CFR part 211. Waiver petitions must contain the information required by...

  3. Replication Study and Meta-Analysis in European Samples Supports Association of the 3p21.1 Locus with Bipolar Disorder

    Vassos, Evangelos; Steinberg, Stacy; Cichon, Sven; Breen, Gerome; Sigurdsson, Engilbert; Andreassen, Ole A; Djurovic, Srdjan; Morken, Gunnar; Grigoroiu-Serbanescu, Maria; Diaconu, Carmen C; Czerski, Piotr M; Hauser, Joanna; Babadjanova, Gulja; Abramova, Lilia I; Mühleisen, Thomas W; Nöthen, Markus M; Rietschel, Marcella; McGuffin, Peter; Clair, David St; Gustafsson, Omar; Melle, Ingrid; Pietiläinen, Olli P H; Ruggeri, Mirella; Tosato, Sarah; Werge, Thomas; Ophoff, Roel A; Rujescu, Dan; Børglum, Anders D; Mors, Ole; Mortensen, Preben B; Demontis, Ditte; Hollegaard, Mads V; van Winkel, Ruud; Kenis, Gunter; De Hert, Marc; Réthelyi, János M; Bitter, István; Rubino, I Alex; Golimbet, Vera; Kiemeney, Lambertus A; van den Berg, Leonard H; Franke, Barbara; Jönsson, Erik G; Farmer, Anne; Stefansson, Hreinn; Stefansson, Kari; Collier, David A

    2012-01-01

    Common genetic polymorphisms at chromosome 3p21.1, including rs2251219 in polybromo 1 (PBRM1), have been implicated in susceptibility to bipolar affective disorder (BP) through genome-wide association studies. Subsequent studies have suggested that this is also a risk locus for other psychiatric ...... phenotypes, including major depression and schizophrenia....

  4. Stability and in vivo behavior of Rh[16aneS4-diol]211At complex: A potential precursor for astatine radiopharmaceuticals

    Introduction: The heavy halogen 211At is of great interest for targeted radiotherapy because it decays by the emission of short-range, high-energy α-particles. However, many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking other 211At labeling strategies. One relatively unexplored approach is to utilize prosthetic groups based on astatinated rhodium (III) complex stabilized with a tetrathioether macrocyclic ligand – Rh[16aneS4-diol]211At. The purpose of the current study was to evaluate the in vitro and in vivo stability of this complex in comparison to its iodine analog – Rh[16aneS4-diol]131I. Methods: Rh[16aneS4-diol]211At and Rh[16aneS4-diol]131I complexes were synthesized and purified by HPLC. The stability of both complexes was evaluated in vitro by incubation in phosphate-buffered saline (PBS) and human serum at different temperatures. The in vivo behavior of the two radiohalogenated complexes was assessed by a paired-label biodistribution study in normal Balb/c mice. Results: Both complexes were synthesized in high yield and purity. Almost no degradation was observed for Rh[16aneS4-diol]131I in PBS over a 72 h incubation. The astatinated analog exhibited good stability in PBS over 14 h. A slow decline in the percentage of intact complex was observed for both tracers in human serum. In the biodistribution study, retention of 211At in most tissues was higher than that of 131I at all time points, especially in spleen and lungs. Renal clearance of Rh[16aneS4-diol]211At and Rh[16aneS4-diol]131I predominated, with 84.1 ± 2.3% and 94.6 ± 0.9% of injected dose excreted via the urine at 4 h. Conclusions: The Rh[16aneS4-diol]211At complex might be useful for constructing prosthetic groups for the astatination of biomolecules and further studies are planned to evaluate this possibility

  5. Focal cortical dysplasia, microcephaly and epilepsy in a boy with 1q21.1-q21.3 duplication.

    Milone, Roberta; Valetto, Angelo; Battini, Roberta; Bertini, Veronica; Valvo, Giulia; Cioni, Giovanni; Sicca, Federico

    2016-05-01

    The recent advance of new molecular technologies like array - Comparative Genomic Hybridization has fostered the detection of genomic imbalances in subjects with intellectual disability, epilepsy, and/or congenital anomalies. Though some of the rearrangements are relatively frequent, their consequences on phenotypes can be strongly variable. We report on a boy harbouring a de novo 8.3 Mb duplication of chromosome 1q21.1-q21.3 whose complex unusual phenotype deserves attention, due to the presence of focal cortical dysplasia, microcephaly, and epilepsy. Loss-of-function (LOF) effects of genes associated with human disease involved in the rearrangement have been only partially established, and have not been previously associated with brain malformations in several deletion syndromes. Less is known, instead, about the consequences of their duplication on neuronal migration and brain development process. Further advance in neuroimaging and genetic research will help in defining their actual role in neurodevelopment and cerebral cortex malformations. PMID:26975584

  6. Interstellar Silicate Dust in the z=0.89 Absorber Towards PKS 1830-211: Crystalline Silicates at High Redshift?

    Aller, Monique C; York, Donald G; Vladilo, Giovanni; Welty, Daniel E; Som, Debopam

    2012-01-01

    We present evidence of a >10-sigma detection of the 10 micron silicate dust absorption feature in the spectrum of the gravitationally lensed quasar PKS 1830-211, produced by a foreground absorption system at redshift 0.886. We have examined more than 100 optical depth templates, derived from both observations of Galactic and extragalactic sources and laboratory measurements, in order to constrain the chemical structure of the silicate dust. We find that the best fit to the observed absorption profile is produced by laboratory crystalline olivine, with a corresponding peak optical depth of tau_10=0.27+/-0.05. The fit is slightly improved upon by including small contributions from additional materials such as silica, enstatite, or serpentine, which suggests that the dust composition may consist of a blend of crystalline silicates. Combining templates for amorphous and crystalline silicates, we find that the fraction of crystalline silicates needs to be at least 95%. Given the rarity of extragalactic sources wit...

  7. GAMMA-RAY FLARING ACTIVITY FROM THE GRAVITATIONALLY LENSED BLAZAR PKS 1830–211 OBSERVED BY Fermi LAT

    Abdo, A. A. [Center for Earth Observing and Space Research, College of Science, George Mason University, Fairfax, VA 22030 (United States); Ackermann, M.; Buehler, R. [Deutsches Elektronen Synchrotron DESY, D-15738 Zeuthen (Germany); Ajello, M. [Space Sciences Laboratory, 7 Gauss Way, University of California, Berkeley, CA 94720-7450 (United States); Allafort, A.; Bechtol, K.; Blandford, R. D.; Borgland, A. W.; Caliandro, G. A.; Cameron, R. A. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Amin, M. A. [Kavli Institute for Cosmology and Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge CB3 0HA (United Kingdom); Baldini, L.; Bellazzini, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Barbiellini, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Bastieri, D.; Buson, S. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, I-35131 Padova (Italy); Bonamente, E. [Istituto Nazionale di Fisica Nucleare, Sezione di Perugia, I-06123 Perugia (Italy); Bregeon, J. [Laboratoire Univers et Particules de Montpellier, Université Montpellier 2, CNRS/IN2P3, Montpellier (France); Brigida, M. [Dipartimento di Fisica " M. Merlin" dell' Università e del Politecnico di Bari, I-70126 Bari (Italy); Bulmash, D., E-mail: sara.buson@pd.infn.it, E-mail: stefano.ciprini@asdc.asi.it, E-mail: justin.finke@nrl.navy.mil, E-mail: dammando@ira.inaf.it, E-mail: stefano.ciprini@asdc.asi.it, E-mail: sara.buson@pd.infn.it, E-mail: justin.finke@nrl.navy.mil, E-mail: dammando@ira.inaf.it [Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02138 (United States); and others

    2015-02-01

    The Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope routinely detects the MeV-peaked flat-spectrum radio quasar PKS 1830–211 (z = 2.507). Its apparent isotropic γ-ray luminosity (E > 100 MeV), averaged over ∼3 years of observations and peaking on 2010 October 14/15 at 2.9 × 10{sup 50} erg s{sup –1}, makes it among the brightest high-redshift Fermi blazars. No published model with a single lens can account for all of the observed characteristics of this complex system. Based on radio observations, one expects time-delayed variability to follow about 25 days after a primary flare, with flux about a factor of 1.5 less. Two large γ-ray flares of PKS 1830–211 have been detected by the LAT in the considered period, and no substantial evidence for such a delayed activity was found. This allows us to place a lower limit of about 6 on the γ-ray flux ratio between the two lensed images. Swift XRT observations from a dedicated Target of Opportunity program indicate a hard spectrum with no significant correlation of X-ray flux with the γ-ray variability. The spectral energy distribution can be modeled with inverse Compton scattering of thermal photons from the dusty torus. The implications of the LAT data in terms of variability, the lack of evident delayed flare events, and different radio and γ-ray flux ratios are discussed. Microlensing effects, absorption, size and location of the emitting regions, the complex mass distribution of the system, an energy-dependent inner structure of the source, and flux suppression by the lens galaxy for one image path may be considered as hypotheses for understanding our results.

  8. Gamma-Ray Flaring Activity from the Gravitationally Lensed Blazar PKS 1830-211 Observed by Fermi LAT

    Abdo, A. A.; Ackermann, M.; Ajello, M.; Allafort, A.; Amin, M. A.; Baldini, L.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Blandford, R. D.; Bonamente, E.; Borgland, A. W.; Bregeon, J.; Brigida, M.; Buehler, R.; Bulmash, D.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caraveo, P. A.; Cavazzuti, E.; Cecchi, C.; Charles, E.; Cheung, C. C.; Chiang, J.; Chiaro, G.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Conrad, J.; Corbet, R. H. D.; Cutini, S.; D'Ammando, F.; de Angelis, A.; de Palma, F.; Dermer, C. D.; Drell, P. S.; Drlica-Wagner, A.; Favuzzi, C.; Finke, J.; Focke, W. B.; Fukazawa, Y.; Fusco, P.; Gargano, F.; Gasparrini, D.; Gehrels, N.; Giglietto, N.; Giordano, F.; Giroletti, M.; Glanzman, T.; Grenier, I. A.; Grove, J. E.; Guiriec, S.; Hadasch, D.; Hayashida, M.; Hays, E.; Hughes, R. E.; Inoue, Y.; Jackson, M. S.; Jogler, T.; Jóhannesson, G.; Johnson, A. S.; Kamae, T.; Knödlseder, J.; Kuss, M.; Lande, J.; Larsson, S.; Latronico, L.; Longo, F.; Loparco, F.; Lott, B.; Lovellette, M. N.; Lubrano, P.; Madejski, G. M.; Mazziotta, M. N.; Mehault, J.; Michelson, P. F.; Mizuno, T.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nemmen, R.; Nuss, E.; Ohno, M.; Ohsugi, T.; Paneque, D.; Perkins, J. S.; Pesce-Rollins, M.; Piron, F.; Pivato, G.; Porter, T. A.; Rainò, S.; Rando, R.; Razzano, M.; Reimer, A.; Reimer, O.; Reyes, L. C.; Ritz, S.; Romoli, C.; Roth, M.; Saz Parkinson, P. M.; Sgrò, C.; Siskind, E. J.; Spandre, G.; Spinelli, P.; Takahashi, H.; Takeuchi, Y.; Tanaka, T.; Thayer, J. G.; Thayer, J. B.; Thompson, D. J.; Tibaldo, L.; Tinivella, M.; Torres, D. F.; Tosti, G.; Troja, E.; Tronconi, V.; Usher, T. L.; Vandenbroucke, J.; Vasileiou, V.; Vianello, G.; Vitale, V.; Waite, A. P.; Werner, M.; Winer, B. L.; Wood, K. S.

    2015-02-01

    The Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope routinely detects the MeV-peaked flat-spectrum radio quasar PKS 1830-211 (z = 2.507). Its apparent isotropic γ-ray luminosity (E > 100 MeV), averaged over ~3 years of observations and peaking on 2010 October 14/15 at 2.9 × 1050 erg s-1, makes it among the brightest high-redshift Fermi blazars. No published model with a single lens can account for all of the observed characteristics of this complex system. Based on radio observations, one expects time-delayed variability to follow about 25 days after a primary flare, with flux about a factor of 1.5 less. Two large γ-ray flares of PKS 1830-211 have been detected by the LAT in the considered period, and no substantial evidence for such a delayed activity was found. This allows us to place a lower limit of about 6 on the γ-ray flux ratio between the two lensed images. Swift XRT observations from a dedicated Target of Opportunity program indicate a hard spectrum with no significant correlation of X-ray flux with the γ-ray variability. The spectral energy distribution can be modeled with inverse Compton scattering of thermal photons from the dusty torus. The implications of the LAT data in terms of variability, the lack of evident delayed flare events, and different radio and γ-ray flux ratios are discussed. Microlensing effects, absorption, size and location of the emitting regions, the complex mass distribution of the system, an energy-dependent inner structure of the source, and flux suppression by the lens galaxy for one image path may be considered as hypotheses for understanding our results.

  9. Radiopharmaceutical Chemistry of Targeted Radiopharmaceutics. Synthesis of 211At-Labeled Radiopharmaceuticals at High Activities for Clinical Use

    Targeted α-particle radiotherapy is an appealing approach to cancer treatment because of the potential for delivering curative doses of radiation to tumor with minimal damage to normal tissue due to a range equivalent to only a few cell diameters. Compared with β-emitters they have significant advantages from a radiobiological perspective. The LET of 211At α-particles is more than 400 times higher than the β-particles emitted by 90Y, in addition the distance between ionizing events is almost the same as that between the two strands of DNA, yielding a high probability of creating non-repairable DNA damage. It gives the ability to kill cancer cells not compromised by hypoxia, dose rate effects or cell cycle position, enhancing their attractiveness for targeted radiotherapy. However, translation of the concept to the clinic has been slow, many obstacles had to be surmounted before clinical studies could be initiated, the first clinical evaluation of a 211At- labeled mAb was made in 2001. This study circumvents many of the challenges to entering clinical studies with 211At. But several problems were encountered in maintaining efficient labeling with escalating radiation dose of alpha-particle likely related to radiolysis. The impact of the radiolysis produced by the α-particle over the labeling chemistry is much higher in comparison with typical β-emitters due to a deposition of energy in the solvent in a highly localized manner two orders of magnitude per unit volume higher than 90Y or 131I. Due to these difficulties a comprehensive basic science study about the radiolytic effects of astatine alpha-particles over the synthesis of 211At-labeled radiopharmaceuticals was carried out. Its main goal was overcoming the problem of the synthesis of 211At-labeled radiopharmaceuticals at the high activities necessaries for therapy and also to extend the shelf life of astatine elutions. Briefly this study held several steps, the first one was to study the role of solvent

  10. 联检NSE、CYFRA21-1、D-二聚体、Fib在肺癌患者中的临床意义%Clinical significance of the combined determination of NSE, CYFRA21-1, D-Dimer, Fibrinogen for the patients with lung cancer

    谢颖; 贾张军; 张云生

    2014-01-01

    Objective To discuss the clinical significance of the combined determination of NSE,CYFRA21-1, D-Dimer, Fibrinogen for lung cancer patients. Methods The levels of serum NSE and CYFRA21-1 were detected by electrochemical analysis in 256 lung cancer patients, 200 patients with benign lung diseases and 200 health subjects. The levels of plasma D-Dimer and Fibrinogen were detected by immunoturbidimetric assays. The relationship of NSE, CYFRA21-1, D-Dimer and Fibrinogen levels with the clinical stages of lung cancer was analyzed by statistics. Results The levels of NSE, CYFRA21-1, D-Dimer and Fibrinogen in patients with lung cancer were significantly higher than those in patients with benign lung diseases and healthy controls(PCYFRA21-1 > D-Dimer > Fibrinogen.CYFRA21-1 showed the highest sensitivity(69.0%) in squamous cellcarcinoma, and NSE showed the highest sensitivity(68.4%%) in smal celllung cancer. The combined determination of NSE, CYFRA21-1, D-Dimer, Fibrinogen might significantly improve the sensitivity for the diagnosis of lung cancer. The combined determination of NSE,CYFRA21-1, D-Dimer, Fibrinogen showed the highest sensitivity(89.8%).NSE,CYFRA21-1, D-Dimer, Fibrinogen were positively related to the clinical stages of lung cancer. With the increasing of clinical stages, the levels of NSE,CYFRA21-1, D-Dimer, Fibrinogen in Ⅲ/Ⅳ stage were significantly higher than those in Ⅰ/Ⅱ stage(correlation coefficie nt(r)=0.315,0.425,0.669,0.523,). Conclusions The combined determination of NSE, CYFRA21-1, D-Dimer, Fibrinogen has an important clinical significance in the clinical diagnosis, differentiation, monitor and clinical stage of lung cancer.%联合检测神经元特异烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)、D-二聚体(D-D)、Fib(纤维蛋白原),探讨其在肺癌患者中的临床意义。方法肺癌组(256例)、肺良性疾病组(200例)和正常对照组(200例)的血清NSE、CYFRA21-1水平采用电化学发光分析法检测,血

  11. Clinical significance in squamous cell lung cancer patients with serum CYFRA21-1 and SCC by ROC curve and cut-off theory%肺鳞癌患者血清CYFRA21-1和SCC检测及ROC曲线和截断点的理论分析

    刘磊; 刘彬; 朱莉莉; 张薇

    2012-01-01

    目的:探讨血清细胞角蛋白19片段(CYFRA21-1)抗原和鳞癌抗原(SCC)对肺鳞癌的临床意义.方法:将研究对象分组,试验组为102例肺鳞癌患者,对照组为53例良性肺病患者.分别采用电化学发光法和酶联免疫法检测血清CYFRA21-1及SCC,测定值用t检验,率比较用x2检验.接受者工作特征(ROC)曲线及截断点选择理论评估CYFRA21-1及SCC的临床价值.结果:肺鳞癌组与良性肺病组CYFRA21-1和SCC水平差异有统计学意义;CYFRA21-1以3.3 ng/mL、SCC以1.5 ng/mL为诊断临界点,CYFRA21-1诊断肺鳞癌敏感性为57.84%,特异性为92.45%,准确性为69.68%,ROC曲线下面积为0.788;SCC诊断肺鳞癌敏感性为33.33%,特异性为92.45%,准确性为53.55%,ROC曲线下面积为0.691;CYFRA21-1诊断肺鳞癌最佳截断点为2.485或2.365 ng/mL,对应敏感性和特异性分别为65.7%、92.5%和67.6%、90.6%;SCC诊断肺鳞癌最佳截断点为0.55 ng/mL,对应敏感性和特异性分别为72.5%和62.3%.随肺鳞癌分期增高,CYFRA21-1和SCC浓度增高差异有统计学意义,CYFRA21-1敏感性增高差异有统计学意义,SCC敏感性无明显变化.结论:CYFRA21-1对肺鳞癌的诊断具有较高的临床价值,而SCC对肺鳞癌的诊断价值较低.%OBJECTIVE: To make further efforts and investigate the clinical significance of cytokeratin fragment 19 (CYFRA21-l)and squamous cell carcinoma antigen(SCC) of serum tumor markers (TM) in the diagnosis of squamous cell lung cancer patients. METHODS: The subjects were divided into two groups: the squamous cell lung cancer group (102 patients) and the benign lung disease group(53 patients). The electric chemisty irradiance was used to examine blood serum CYFRA21-1 and SCC was examined by ELISA. The results were examined by z-test, and the rate comparison were examined by Chi-square test. Receiver operator characteristic curve and cut-off choice theory were used to value the results. RESULTS: Significant

  12. The CT Findings and the Peak SUV on PET/CT according to the Levels of Cyfra 21-1 and CEA in Patients with Non-Small Cell Lung Carcinoma

    We wanted to evaluate the CT findings and the peak SUV according to the levels of cyfra 21-1 and CEA in patients with non-small cell lung carcinoma (NSCLC). We evaluated the TNM staging, cell types, the CT findings and peak SUV of the NSCLC in 234 patients with NSCLC according to the tumor marker levels. The correlations of the CT findings and the peak SUV with the tumor markers were evaluated in 35 patients with stage I disease. The sensitivities of the combined tumor markers cyfra 21-1 and CEA in the NSCLC for each TNM staging (I-IV) were 48.5%, 66.7%, 78.3% and 84.3%, respectively (p<0.05). Cyfra 21-1 was more sensitive for squamous cell carcinoma and CEA was more sensitive for adenocarcinoma. The tumor size, tumor necrosis and peak SUV were greater in the NSCLC with an elevated cyfra 21-1 level than that in the NSCLC without an elevated cyfra 21-1 level (p<0.05). For stage I disease, the level of cyfra 21-1 was linearly correlated with the tumor size (r=0.54) and the peak SUV (r=0.46), and the level of CEA was high in the spiculated masses (p<0.05). The NSCLC with an elevated cyfra 21-1 level shows larger, more frequently necrosis and a higher peak SUV than the NSCLC without an elevated Cyfra 21-1 level. For stage 1 disease, the tumor size and peak SUV correlate with the level of cyfra 21-1, and spiculated masses show an elevated level of CEA

  13. A novel unbalanced de novo translocation der(5t(4;5(q26;q21.1 in adult T-cell precursor lymphoblastic leukemia

    Kjeldsen Eigil

    2012-05-01

    Full Text Available Abstract We here describe a novel unbalanced de novo translocation der(5t(4;5(q26;q21.1 in a 39-year-old male diagnosed with acute T-cell lymphoblastic leukemia. Bone marrow (BM was massively infiltrated with 85 % highly proliferative polymorphic T-cell precursors. Immunologically, the malignant cells stained positive for CD7, CD34, intracytoplasmic CD3+, TdT + and negative for CD3 and CD5. G-banded chromosome analysis of BM cells showed the normal karyotype 46,XY[25] whereas BAC-based aCGH analysis revealed partial gain of 4q and partial loss of 5q. Multicolor karyotyping confirmed the presence of an unbalanced der(5t(4;5 as the sole structural abnormality. Subsequent high-resolution oligonucleotide-based aCGH analysis showed that the der(5t(4;5(q26;q21.1 resulted in partial trisomy of 4q26qter (117,719,015-190,613,014 and partial monosomy of 5q21.1qter (100,425,442-180,857,866 and that there was no indication of any gene disruptions resulting from the breakages. Interphase FISH analysis using BAC-based specific probes for 4q26 and 5q21.1 confirmed the breakpoints and revealed approximately 80 % abnormal cells accordingly. At 4q26 the MIR1973 gene is located centromeric to the breakpoint in the copy number neutral region and the TRAM1L1 gene is located within the gained region. At 5q21.1 the genes ST8SIA4 and MIR548p are located centromeric to the breakpoint and no known genes up to approximately 1 Mb telomeric to the breakpoint in the copy number loss region. Interestingly, only the gene ST8SIA4 at 5q21.1 have been implicated in T-cell regulation as it encodes one of the key enzymes for polysialysation of surface proteins on dendritic cells which are important regulators for T-cell proliferation. The der(5t(4;5 is thought to play a crucial role in the pathogenesis of acute T-ALL due to either gain of 4q, the loss of 5q, or deregulation of genes in proximity to the breakpoints.

  14. Glomerular filtration rate after alpha-radioimmunotherapy with 211At-MX35-F(ab')2: a long-term study of renal function in nude mice

    Back, T.; Haraldsson, B.; Hultborn, R; Jensen, H.; Johansson, M.E.; Lindegren, S.; Jacobsson, L.

    2009-01-01

    Besides bone marrow, the kidneys are often dose-limiting organs in internal radiotherapy. The effects of high-linear energy transfer (LET) radiation on the kidneys after alpha-radioimmunotherapy (alpha-RIT) with the alpha-particle emitter, (211)At, were studied in nude mice by serial measurements.......0 +/- 4.1 Gy (mean +/- SEM), tumor- and non-tumor-bearing animals, respectively. The reduction in GFR progressed with time, and at the later time interval, (31-67 weeks) the corresponding absorbed doses were 7.5 +/- 2.4 and 11.3 +/- 2.3 Gy, respectively, suggesting that the effects of radiation on the...... kidneys were manifested late. Examination of the kidney sections showed histologic changes that were overall subdued. Following alpha-RIT with (211)At-MX35-F(ab')(2) at levels close to the dose limit of severe myelotoxicity, the effects found on renal function were relatively small, with only minor to...

  15. Computation of the chiral condensate using N{sub f}=2 and N{sub f}=2+1+1 dynamical flavors of twisted mass fermions

    Cichy, K. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Poznan Univ. (Poland). Faculty of Physics; Garcia-Ramos, E. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Humboldt-Universitaet, Berlin (Germany); Jansen, K. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Shindler, A. [Forschungszentrum Juelich (Germany). IAS; Forschungszentrum Juelich (Germany). IKP; Forschungszentrum Juelich (Germany). JCHP; Collaboration: European Twisted Mass Collaboration

    2013-12-15

    We apply the spectral projector method, recently introduced by Giusti and Luescher, to compute the chiral condensate using N{sub f}=2 and N{sub f}=2+1+1 dynamical flavors of maximally twisted mass fermions. We present our results for several quark masses at three different lattice spacings which allows us to perform the chiral and continuum extrapolations. In addition we report our analysis on the O(a) improvement of the chiral condensate for twisted mass fermions. We also study the effect of the dynamical strange and charm quarks by comparing our results for N{sub f}=2 and N{sub f}=2+1+1 dynamical flavors.

  16. Nucleon form factors and moments of generalized parton distributions using N{sub f}= 2+1+1 twisted mass fermions

    Alexandrou, C. [Univ. of Cyprus, Nicosia (Cyprus). Dept. of Physics; Cyprus Institute, Nicosia (Cyprus). Computation-based Science and Technology Research Center; Constantinou, M.; Kallidonis, C. [Univ. of Cyprus, Nicosia (Cyprus). Dept. of Physics; Dinter, S.; Drach, V. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Jansen, K. [Univ. of Cyprus, Nicosia (Cyprus). Dept. of Physics; Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Koutsou, G. [Cyprus Institute, Nicosia (Cyprus). Computation-based Science and Technology Research Center; Collaboration: European Twisted Mass Collaboration

    2013-04-15

    We present results on the axial and the electromagnetic form factors of the nucleon, as well as, on the first moments of the nucleon generalized parton distributions using maximally twisted mass fermions. We analyze two N{sub f}=2+1+1 ensembles having pion masses of 210 MeV and 354 MeV at two values of the lattice spacing. The lattice scale is determined using the nucleon mass computed on a total of 18 N{sub f}=2+1+1 ensembles generated at three values of the lattice spacing, a. The renormalization constants are evaluated non-perturbatively with a perturbative subtraction of O(a''2)-terms. The moments of the generalized parton distributions are given in the MS scheme at a scale of {mu}=2 GeV. We compare with recent results obtained using different discretization schemes. The implications on the spin content of the nucleon are also discussed.

  17. $K$ and $D$ oscillations in the Standard Model and its extensions from $N_f=2+1+1$ Twisted Mass LQCD

    Carrasco, Nuria; Frezzotti, Roberto; Giménez, Vicent; Lubicz, Vittorio; Rossi, Giancarlo; Sanfilippo, Francesco; Tarantino, Cecilia

    2013-01-01

    We present the first $N_f=2+1+1$ results for the matrix elements of the operators describing neutral $K$ and $D$ mixing in the Standard Model and its extensions. The combination of maximally twisted sea quarks and Osterwalder-Seiler valence quarks ensures $\\mathcal{O}(a)$-improvement and continuum like renormalization pattern. We have used the $N_f=2+1+1$ dynamical quark gauge configurations generated by ETMC. Simulations include three lattice spacings in the interval $[0.06:0.09]$ fm and pseudoscalar meson masses in the range $[230:500]$ MeV. Our results are extrapolated to the continuum limit and to the physical quark masses. The calculation of the renormalization constants has been performed non-perturbatively in the RI-MOM scheme.

  18. First principles study of (Cd, Hg, In, Tl, Sn, Pb, As, Sb, Bi, Se) modified Pt(111), Pt(100) and Pt(211) electrodes as CO oxidation catalysts

    Tripkovic, Vladimir

    2015-01-01

    CO oxidation is a prototype reaction for studying oxidation of small organic molecules. Certain adatom modified Pt electrodes have a large promotional effect on CO oxidation. However, the effect is often coverage dependent, and has a limited effect due to short lifetimes of the adatoms. The...... coverage dependence as a function of potential for ten different adatom species (Cd, Hg, In, Tl, Sn, Pb, As, Sb, Bi, Se) on bare and CO saturated Pt(111), Pt(100) and Pt(211) surfaces has been established by means of Density Functional Theory calculations. Most of the adatoms are very stable under standard...... conditions and remain anchored to the surface until high potentials in supporting electrolytes. The stability is contingent on the electrode roughness and reduces in the following order: Pt(211) ≈ Pt(100) > Pt(111), except for Se adatoms, in which case the trend is reversed. The activity for CO oxidation...

  19. 头颈鳞状细胞癌患者血清Cyfra21-1检测的临床意义%Clinical significance of Cyfra21-1 in patients with squamous cell carcinoma of the head and neck

    徐先发; 谭静

    2011-01-01

    OBJECTIVE To evaluate the clinical significance of Cyfra 21-1 in patients with head and neck squamous cell carcinoma (HNSCC) . METHODS Before and after treatment, the serum concentration of Cyfra 21-1 was measured by ELISA assay in 60 patients with HNSCC, 40 patients with benign tumors of the thyroid. Also 20 healthy adults were included in this reseach as controls. Statistical analysis was performed using SPSS11.5 statistical package. RESULTS Serum levels of Cyfra21-1 were (6.49±2.90) ng/ml in preoperative patients with HNSCC, (3.39 ±1.45) ng/ml in postoperative patients with HNSCC, (2.01 ± 0.83) ng/ml in preoperative patients with benign tumors of the thyroid, (1.98±0.85) ng/ml in postoperative patients with benign tumors of the thyroid and (1.90 ± 0.69) ng/ml in control group, respectively. Serum levels of Cyfra21-1 in preoperative patients with HNSCC were significantly higher than those of benign tumors of the thyroid (t=4.69, P0.05) .After operation, levels of Cyfra21-1 in HNSCC decreased significantly (t=3.57, P0.05).The serum concentrations of Cyfra 21-1 in preoperative patients with HNSCC were statistically correlated with the T-stage of the disease(t=2.35, P0.05) or gender (t=1.32, P>0.05) . In 4 patients with local tumor recurrence during follow-up, serum Cyfra21-1 levels showed a significant increase compared with the levels after surgery. At the cutoff value of 3.69 ng/ml, the diagnostic sensitivity and specificity of Cyfra 21-1 for HNSCC were 80.0% and 91.7%, respectively. CONCLUSION CYFRA 21-1 can be used as an useful tumor marker of HNSCC in diagnosis,evaluation of therapeutic effect, monitoring of tumorrecurrence and the prognosis.%目的 探讨血清Cyfra21-1在头颈鳞状细胞癌(head and neck squamous cell carcinoma,HNSCC)中的临床意义.方法 采用双抗体夹心ELISA法对随机选取的60例HNSCC患者,40例甲状腺良性肿瘤患者,20名健康对照组进行血清Cyfra2l-1检测.应用SPSS 11.5统计软

  20. Decreased levels of serum cytokeratin 19 fragment CYFRA 21-1 predict objective response to chemotherapy in patients with non-small cell lung cancer

    Pang, Li; Jing WANG; Jiang, Yanwen; Chen, Liangan

    2013-01-01

    Diagnostic tools capable of predicting early responses to chemotherapy are required to improve the individual management of cancer patients. The present study aimed to evaluate the prognostic significance of the serum tumor markers CYFRA 21-1, carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), carbohydrate antigen (CA) 125, and CA 19-9 for predicting responses to different chemotherapy regimens in patients with non-small cell lung cancer (NSCLC). A total of 276 patients with posto...

  1. Diagnostic values of serum tumor markers Cyfra21-1, SCCAg, ferritin, CEA, CA19-9, and AFP in oral/oropharyngeal squamous cell carcinoma

    Yang, Kai

    2016-01-01

    Chuanshu Yuan, Kai Yang, Hong Tang, Dan Chen Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China Background: At present, the research on serum tumor markers in the early diagnosis of malignant tumors has aroused widespread concern. The aim of this study was to investigate the diagnostic values of serum tumor markers cytokeratin 19 fragment (Cyfra21-1), squamous cell carcinoma antigen (SC...

  2. Diagnostic values of serum tumor markers Cyfra21-1, SCCAg, ferritin, CEA, CA19-9, and AFP in oral/oropharyngeal squamous cell carcinoma

    Yuan CS; Yang K; Tang H; Chen D

    2016-01-01

    Chuanshu Yuan, Kai Yang, Hong Tang, Dan Chen Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China Background: At present, the research on serum tumor markers in the early diagnosis of malignant tumors has aroused widespread concern. The aim of this study was to investigate the diagnostic values of serum tumor markers cytokeratin 19 fragment (Cyfra21-1), squamous cell carcinoma antigen (SCCAg)...

  3. Analysis in patients of the Hospital A.C. Camargo of two tumors markers: CA-72.4 and CYFRA-21.1

    The behavior of two tumor markers, CA-72.4 and CYFRA-19.9 was analysed in patients of the Hospital A.C. Camargo. The measurement of CA-272.4 serum levels was performed by an automated chemo luminescence assay in 49 patients and proved useful in the two groups analyzed, patients with esophageal tumors and with gastric tumors. In both cases, there was an increase in sensitivity when measurements of this marker was added to that of carcinoembryonic antigen (CEA) and of CA-19.9. The most sensitive associations were of CA-72.4 and CA-19.9 for esophageal tumors and of CA-72.4 and CEA for the gastric tumors. The maker CYFRA-21.1 was analyzed by a radioimmunoassay in 102 normal blood donors and in 20 patients with lung cancer. Among these, CYFRA-21.1 was altered in 55% of the cases. Therefore, CYFRA-21.1 could be considered, as the neuron-specific enolase (NSE), very useful tool for the follow-up lung cancer patients. (author)

  4. An automated radiosynthesis of 2-[11C]thymidine using anhydrous [11C]urea derived from [11C]phosgene

    2-[11C]Thymidine has been produced from [11C]methane via [11C]phosgene and [11C]urea. Anhydrous [11C]urea was prepared from [11C]phosgene by reaction with liquid ammonia. This novel approach avoids the problems associated with the synthesis of anhydrous [11C]urea from [11C]cyanide. A fully automated system based on a modular approach and under PLC control has been developed. The system provides 2-[11C]thymidine reliably and reproducibly for clinical PET studies. The radiosynthesis takes 45-50 min from [11C]methane and the average yield was 1.5-3.3 GBq (40-90 mCi). The specific radioactivity was typically in the range 29.6-51.8 GBq μmol-1 (0.8-1.4 Ci μmol-1) at EOS corresponding to 6-12 μg of stable thymidine. The radiochemical yield of 2-[11C]thymidine was ca. 14% from [11C]methane

  5. Synthesis and biological evaluation in mice of (2-[11C]methoxy)-6',7'-dihydrorotenol, a second generation rotenoid for marking mitochondrial complex I activity

    Evidence has accumulated suggesting that impairment of the function of the complexes of the mitochondrial respiratory chain might be involved in the pathology of neurological diseases including Parkinson's and Huntington's diseases. Recently we reported the synthesis of (2-[11C]methoxy)rotenone ([11C]ROT) as a tool for in vivo studies of complex I. In an effort to develop a complex I imaging radiotracer which might be easier to synthesize and less likely to be metabolized, we prepared (2-[11C]methoxy)-6',7'-dihydrorotenol ([11C]DHROT). The radiotracer was synthesized by [11C]methylation of 2-O-desmethyl-6',7'-dihydrorotenol under basic [11C]alkylation conditions. (2-[11C]Methoxy)-6',7'-dihydrorotenol was produced in 30-35% radiochemical yields (decay corrected), with synthesis times shorter than 35 min. Radiochemical purities were over 95% and specific activities averaged 1000 Ci/mmol. The brain distributions of [11C]ROT and [11C]DHROT were investigated in mice after intravenous injections. For both radiotracers, distribution of radioactivity was similar in all brain regions examined. However, significantly higher uptake was observed with [11C]DHROT than with [11C]ROT, indicating that the alterations introduced in the structure of rotenone during the design of [11C]DHROT resulted in a tracer with greater brain barrier permeability

  6. Avaliação dos valores sérico e pleural dos marcadores tumorais CEA, CYFRA21-1 e CA 15-3 em portadores de derrame pleural Evaluation of serum and pleural levels of the tumor markers CEA, CYFRA21-1 and CA 15-3 in patients with pleural effusion

    Isabella Coimbra Wagner

    2007-04-01

    Full Text Available OBJETIVO: Dosar os marcadores tumorais antígeno carcinoembrionário (CEA, fragmento da citoqueratina 19 (CYFRA21-1 e antígeno glicosídico associado a tumor 15-3 (CA 15-3 em sangue e líquido pleural de portadores de derrames pleurais benignos e malignos, avaliando a sensibilidade de cada um deles nesses fluidos. MÉTODOS: Avaliamos prospectivamente 85 pacientes com derrame pleural. O estudo do líquido pleural obedeceu a critérios determinados pela literatura. A dosagem dos marcadores foi realizada por eletroquimioluminescência. A sensibilidade foi determinada sob a condição de que a especificidade fosse > 90%. RESULTADOS: Foram diagnosticados 36 casos malignos (42,4%, 30 benignos (35,3%; em 19 pacientes (22,3%, o diagnóstico foi inconclusivo. Nos casos malignos, os valores de CEA e CYFRA21-1 foram maiores no líquido pleural do que no sangue, fato não observado para o CA 15-3. Nos casos benignos, os valores do CYFRA21-1 foram maiores no líquido pleural do que no soro, enquanto que para o CEA e o CA 15-3, ocorreu o oposto. Todos os marcadores apresentaram diferença significativa entre os casos malignos e benignos, em líquido pleural e soro. Foi encontrada sensibilidade para CEA, CYFRA21-1 e CA 15-3 no líquido pleural de 69,4%, 69,4% e 66,7%, respectivamente e quando associados, foi 80,6%. No soro, a sensibilidade foi 57,1, 71,4 e 48,6% para CEA, CYFRA21-1 e CA 15-3, respectivamente, e quando associados, foi 77%. CONCLUSÃO: Os resultados sugerem que a utilização desses marcadores pode ser útil na diferenciação entre derrames pleurais malignos e benignos.OBJECTIVE: To determine the levels of the tumor markers carcinoembryonic antigen (CEA, cytokeratin 19 fragment (CYFRA21-1 and carbohydrate antigen 15-3 (CA 15-3 in the blood and pleural fluid of patients with benign or malignant pleural effusion, evaluating the sensitivity of each marker in these fluids. METHODS: We prospectively evaluated 85 patients with pleural effusion. The

  7. The electric dipole moment of the neutron from N{sub f}=2+1+1 twisted mass fermions

    Alexandrou, C.; Athenodorou, A.; Constantinou, M. [Cyprus Univ., Nicosia (Cyprus). Dept. of Physics; Cyprus Institute, Nicosia (Cyprus). Computation-based Science and Technology Research Center; Hadjiyiannakou, K. [Cyprus Univ., Nicosia (Cyprus). Dept. of Physics; Cyprus Institute, Nicosia (Cyprus). Computation-based Science and Technology Research Center; George Washington Univ., Washington, DC (United States). Dept. of Physics; Jansen, K. [DESY Zeuthen (Germany). NIC; Koutsou, G. [Cyprus Institute, Nicosia (Cyprus). Computation-based Science and Technology Research Center; Ottnad, K. [Cyprus Univ., Nicosia (Cyprus). Dept. of Physics; Bonn Univ. (Germany). Helmholtz-Institut fuer Strahlen- und Kernphysik and Bethe Center for Theoretical Physics; Petschlies, M. [Cyprus Institute, Nicosia (Cyprus). Computation-based Science and Technology Research Center; Bonn Univ. (Germany). Helmholtz-Institut fuer Strahlen- und Kernphysik and Bethe Center for Theoretical Physics

    2015-11-15

    We extract the neutron electric dipole moment (nEDM) vertical stroke vector d{sub n} vertical stroke on configurations produced with N{sub f}=2+1+1 twisted mass fermions with lattice spacing of a ≅0.082 fm and a light quark mass that corresponds to M{sub π} ≅ 373 MeV. We do so by evaluating the CP-odd form factor F{sub 3} for small values of the CP-violation parameter θ in the limit of zero momentum transfer. This limit is extracted using the usual parametrization but in addition position space methods. The topological charge is computed via cooling and gradient flow using the Wilson, Symanzik tree-level improved and Iwasaki actions for smoothing. We obtain consistent results for all choices of smoothing procedures and methods to extract F{sub 3} at zero momentum transfer. For the ensemble analyzed we find a value of nEDM of vertical stroke vector d{sub n} vertical stroke /θ=0.045(6)(1) e.fm.

  8. The effect of film thickness on critical properties of YBCO film fabricated by TFA-MOD using 211-process

    YBCO films were fabricated by the TFA-MOD method using the '211-process', and the effects of the film thickness on phase formation, microstructure, texture evolution, and critical properties were evaluated. Various film thicknesses ranging from 0.41 μm to 2.14 μm were obtained by repeating the dip coating and calcining processes one to five times. The critical properties varied significantly with the film thickness. The Ic increased from 35 to 105 A/cm-width with increasing the film thickness from 0.41 μm to 1.17 μm. On the other hand, the corresponding Jc remained almost constant in the range of 0.76-0.90 MA/cm2. With further increases in thickness, these values decreased drastically, which was attributed to the degraded microstructure, i.e., the formation of BaF2 and a-axis grains and degraded texture and surface morphology arising from the insufficient heat treatment time. It is believed that the optimum thickness for improving both the Ic and Jc values is approximately 1.17 μm

  9. Up, down, strange and charm quark masses with Nf=2+1+1 twisted mass lattice QCD

    We present a lattice QCD calculation of the up, down, strange and charm quark masses performed using the gauge configurations produced by the European Twisted Mass Collaboration with Nf=2+1+1 dynamical quarks, which include in the sea, besides two light mass degenerate quarks, also the strange and charm quarks with masses close to their physical values. The simulations are based on a unitary setup for the two light quarks and on a mixed action approach for the strange and charm quarks. The analysis uses data at three values of the lattice spacing and pion masses in the range 210–450 MeV, allowing for accurate continuum limit and controlled chiral extrapolation. The quark mass renormalization is carried out non-perturbatively using the RI′-MOM method. The results for the quark masses converted to the MS¯ scheme are: mud(2 GeV)=3.70(17) MeV, ms(2 GeV)=99.6(4.3) MeV and mc(mc)=1.348(46) GeV. We obtain also the quark mass ratios ms/mud=26.66(32) and mc/ms=11.62(16). By studying the mass splitting between the neutral and charged kaons and using available lattice results for the electromagnetic contributions, we evaluate mu/md=0.470(56), leading to mu=2.36(24) MeV and md=5.03(26) MeV

  10. Introduction to benchmark dose methods and U.S. EPA's benchmark dose software (BMDS) version 2.1.1

    Traditionally, the No-Observed-Adverse-Effect-Level (NOAEL) approach has been used to determine the point of departure (POD) from animal toxicology data for use in human health risk assessments. However, this approach is subject to substantial limitations that have been well defined, such as strict dependence on the dose selection, dose spacing, and sample size of the study from which the critical effect has been identified. Also, the NOAEL approach fails to take into consideration the shape of the dose-response curve and other related information. The benchmark dose (BMD) method, originally proposed as an alternative to the NOAEL methodology in the 1980s, addresses many of the limitations of the NOAEL method. It is less dependent on dose selection and spacing, and it takes into account the shape of the dose-response curve. In addition, the estimation of a BMD 95% lower bound confidence limit (BMDL) results in a POD that appropriately accounts for study quality (i.e., sample size). With the recent advent of user-friendly BMD software programs, including the U.S. Environmental Protection Agency's (U.S. EPA) Benchmark Dose Software (BMDS), BMD has become the method of choice for many health organizations world-wide. This paper discusses the BMD methods and corresponding software (i.e., BMDS version 2.1.1) that have been developed by the U.S. EPA, and includes a comparison with recently released European Food Safety Authority (EFSA) BMD guidance.

  11. Up, down, strange and charm quark masses with Nf=2+1+1 twisted mass lattice QCD

    N. Carrasco

    2014-10-01

    Full Text Available We present a lattice QCD calculation of the up, down, strange and charm quark masses performed using the gauge configurations produced by the European Twisted Mass Collaboration with Nf=2+1+1 dynamical quarks, which include in the sea, besides two light mass degenerate quarks, also the strange and charm quarks with masses close to their physical values. The simulations are based on a unitary setup for the two light quarks and on a mixed action approach for the strange and charm quarks. The analysis uses data at three values of the lattice spacing and pion masses in the range 210–450 MeV, allowing for accurate continuum limit and controlled chiral extrapolation. The quark mass renormalization is carried out non-perturbatively using the RI′-MOM method. The results for the quark masses converted to the MS¯ scheme are: mud(2 GeV=3.70(17 MeV, ms(2 GeV=99.6(4.3 MeV and mc(mc=1.348(46 GeV. We obtain also the quark mass ratios ms/mud=26.66(32 and mc/ms=11.62(16. By studying the mass splitting between the neutral and charged kaons and using available lattice results for the electromagnetic contributions, we evaluate mu/md=0.470(56, leading to mu=2.36(24 MeV and md=5.03(26 MeV.

  12. A novel form of distal hereditary motor neuronopathy maps to chromosome 9p21.1-p12.

    Christodoulou, K; Zamba, E; Tsingis, M; Mubaidin, A; Horani, K; Abu-Sheik, S; El-Khateeb, M; Kyriacou, K; Kyriakides, T; Al-Qudah, A K; Middleton, L

    2000-12-01

    Distal hereditary motor neuronopathies (dHMNs) form a heterogeneous group of rare disorders characterized by distal weakness and wasting in the limbs with no significant sensory involvement. Harding has classified dHMNs into seven categories based on clinical and genetic criteria. We report a novel form of autosomal recessive dHMN in 7 consanguineous families located in the Jerash region of Jordan. Onset of the disease is between 6 and 10 years of age and is characterized by weakness and atrophy of the lower limbs associated with pyramidal features. Within 2 years, symptoms progress to the upper limbs. Neurophysiological studies typically show normal conduction velocities, reduced compound motor action potential amplitudes, normal sensory nerve action potentials, and chronic neurogenic changes on needle electromyography. No significant abnormalities are seen on sural nerve biopsy. We call this novel form of dHMN Jerash hereditary motor neuronopathy. We studied the families at the molecular genetic level and mapped the Jerash hereditary motor neuronopathy gene to an approximately 0.54-cM region on chromosome 9p21.1-p12, flanked by microsatellite polymorphic marker loci D9S1845 and D9S1791. A maximum LOD score of 19.80 at theta = 0.001 was obtained between the disease and locus D9S1878. PMID:11117544

  13. An ALMA Early Science survey of molecular absorption lines toward PKS1830-211 -- Analysis of the absorption profiles

    Muller, S; Guelin, M; Gerin, M; Aalto, S; Beelen, A; Black, J H; Curran, S J; Darling, J; Dinh-V-Trung,; Garcia-Burillo, S; Henkel, C; Horellou, C; Martin, S; Marti-Vidal, I; Menten, K M; Murphy, M T; Ott, J; Wiklind, T; Zwaan, M A

    2014-01-01

    We present the first results of an ALMA spectral survey of strong absorption lines for common interstellar species in the z=0.89 molecular absorber toward the lensed blazar PKS1830-211. The dataset brings essential information on the structure and composition of the absorbing gas in the foreground galaxy. In particular, we find absorption over large velocity intervals (gtrsim 100 km/s) toward both lensed images of the blazar. This suggests either that the galaxy inclination is intermediate and that we sample velocity gradients or streaming motions in the disk plane, that the molecular gas has a large vertical distribution or extraplanar components, or that the absorber is not a simple spiral galaxy but might be a merger system. The number of detected species is now reaching a total of 42 different species plus 14 different rare isotopologues toward the SW image, and 14 species toward the NE line-of-sight. The abundances of CH, H2O, HCO+, HCN, and NH3 relative to H2 are found to be comparable to those in the G...

  14. The electric dipole moment of the neutron from $N_f=2+1+1$ twisted mass fermions

    Alexandrou, Constantia; Constantinou, Martha; Hadjiyiannakou, Kyriakos; Jansen, Karl; Koutsou, Giannis; Ottnad, Konstantin; Petschlies, Marcus

    2015-01-01

    We extract the neutron electric dipole moment (nEDM) $ \\vert \\vec{d}_n \\vert $ on configurations produced with $N_f=2+1+1$ twisted mass fermions with lattice spacing of $a \\simeq 0.082$ fm and a light quark mass that corresponds to $M_{\\pi} \\simeq 373$ MeV. We do so by evaluating the $CP$-odd form factor $F_3$ for small values of the $CP$-violation parameter $\\theta$ in the limit of zero momentum transfer. This limit is extracted using the usual parametrization but in addition position space methods. The topological charge is computed via cooling and gradient flow using the Wilson, Symanzik tree-level improved and Iwasaki actions for smoothing. We obtain consistent results for all choices of smoothing procedures and methods to extract $F_3$ at zero momentum transfer. For the ensemble analyzed we find a value of nEDM of $\\vert \\vec{d}_n \\vert / \\theta = -0.045(6)(1) {\\rm e} \\cdot {\\rm fm}$.

  15. Polyhydroquinone-graphene composite as new redox species for sensitive electrochemical detection of cytokeratins antigen 21-1.

    Wang, Huiqiang; Rong, Qinfeng; Ma, Zhanfang

    2016-01-01

    Polyhydroquinone-graphene composite as a new redox species was synthesized simply by a microwave-assisted one-pot method through oxidative polymerization of hydroquinone by graphene oxide, which exhibited excellent electrochemical redox activity at 0.124 V and can remarkably promote electron transfer. The as-prepared composite was used as immunosensing substrate in a label-free electrochemical immunosensor for the detection of cytokeratins antigen 21-1, a kind of biomarker of lung cancer. The proposed immunosensor showed wide liner range from 10 pg mL(-1) to 200 ng mL(-1) with a detection limit 2.3 pg mL(-1), and displayed a good stability and selectivity. In addition, this method has been used for the analysis of human serum sample, and the detection results showed good consistence with those of ELISA. The present substrate can be easily extended to other polymer-based nanocomposites. PMID:27464571

  16. Utility of squamous cell carcinoma antigen, carcinoembryonic antigen, Cyfra 21-1 and neuron specific enolase in lung cancer diagnosis: a prospective study from China

    SONG Wei-an; LIU Xi; TIAN Xiao-dong; WANG Wei; LIANG Chao-yang; ZHANG Tao; GUO Jun-tang; PENG Yang-hong; ZHOU Nai-kang

    2011-01-01

    Background Early detection and diagnosis is urgent for the sake of effective treatment strategy for lung cancer.However,a convenient,economical and relatively precise method is not available.We here report a prospective study to find the possible value of the combined use of four popular tumor markers in the early diagnosis of lung cancer among patients with suspicious nodules in the lung.Methods Six hundred and sixty inpatients with suspicious nodules in the lung were divided into a lung cancer group and a benign pulmonary tumor group according to post-operative histological examinations.Serum levels of four tumor markers including squamous cell carcinoma antigen (SCC),carcinoembryonic antigen (CEA),Cyfra 21-1 and neuron specific enolase (NSE) were assayed for each patient.Receiver operating characteristic (ROC) curves were constructed for each tumor marker.The power of lung cancer diagnosis of each tumor marker,as well as a combination of them were analyzed and compared.Results The serum levels (median,range) of SCC,CEA,Cyfra 21-1 and NSE were 0.44 (0.01-35.70) ng/ml,2.49(0.30-26.78) ng/ml,2.30 (0.82-73.33) ng/ml and 10.54 (0.10-56.41) ng/ml respectively in lung cancer group,and were 0.32 (0.01-0.90) ng/ml,1.60 (0.20-8.93) ng/ml,1.41 (0.72-4.82) ng/ml and 9.36 (6.56-24.24) ng/ml respectively in the benign pulmonary tumor group.The difference in each tumor marker between the two groups was significant (P <0.05).The ROCs of SCC,CEA,Cyfra 21-1 and NSE were 0.702 (95% CI,0.654-0.751),0.611 (95% CI,0.563-0.659),0.650(95% CI,0.601-0.700) and 0.598 (95% CI,0.542-0.654) respectively,indicating very low power of these four tumor markers.When a combination of SCC,CEA,Cyfra 21-1 and NSE were employed,the diagnosis power was strengthened.Conclusion SCC,CEA,Cyfra 21-1 and NSE are valuable in the early diagnosis of lung cancer among suspicious nodules in the lung,especially when they were assayed together for one patient.

  17. High-throughput microRNA (miRNAs arrays unravel the prognostic role of MiR-211 in pancreatic cancer.

    Elisa Giovannetti

    Full Text Available BACKGROUND: Only a subset of radically resected pancreatic ductal adenocarcinoma (PDAC patients benefit from chemotherapy, and identification of prognostic factors is warranted. Recently miRNAs emerged as diagnostic biomarkers and innovative therapeutic targets, while high-throughput arrays are opening new opportunities to evaluate whether they can predict clinical outcome. The present study evaluated whether comprehensive miRNA expression profiling correlated with overall survival (OS in resected PDAC patients. METHODOLOGY/PRINCIPAL FINDINGS: High-resolution miRNA profiles were obtained with the Toray's 3D-Gene™-miRNA-chip, detecting more than 1200 human miRNAs. RNA was successfully isolated from paraffin-embedded primary tumors of 19 out of 26 stage-pT3N1 homogeneously treated patients (adjuvant gemcitabine 1000 mg/m(2/day, days-1/8/15, every 28 days, carefully selected according to their outcome (OS30 months (N = 6, i.e. short/long-OS. Highly stringent statistics included t-test, distance matrix with Spearman-ranked correlation, and iterative approaches. Unsupervised hierarchical analysis revealed that PDACs clustered according to their short/long-OS classification, while the feature selection algorithm RELIEF identified the top 4 discriminating miRNAs between the two groups. These miRNAs target more than 1500 transcripts, including 169 targeted by two or more. MiR-211 emerged as the best discriminating miRNA, with significantly higher expression in long- vs. short-OS patients. The expression of this miRNA was subsequently assessed by quantitative-PCR in an independent cohort of laser-microdissected PDACs from 60 resected patients treated with the same gemcitabine regimen. Patients with low miR-211 expression according to median value had a significantly shorter median OS (14.8, 95%CI = 13.1-16.5, vs. 25.7 months, 95%CI = 16.2-35.1, log-rank-P = 0.004. Multivariate analysis demonstrated that low miR-211 expression was an

  18. 我国“211工程”大学高层领导群体特征的履历分析%Curriculum Vitae Analysis on the Leadership Characteristics in China’s“211 Project”Universities

    高八民

    2015-01-01

    The article analyzed the group characteristics of 567 high-level leaders in 112 China’s“211 Pro-ject”universities based on their curriculum vitae. And the results show:(1)on demographic,the age of the senior leaders in the universities is about 55 years old,and most of them are male and Han nationality. It seems that the higher of the university level,the older of its leader. And there is still the“glass ceiling”phenomenon-the female leaders are difficult promoted in the universities,but no ethnic discrimination. (2)On academic,compared with the administrative leaders and the vice leaders,the party leaders and the principal leaders should have higher edu-cational background,professional qualifications and international level. And compared with the person who comes from other academic backgrounds,it seems that those who from science background have more opportunities to be a senior leader.(3)On working position,the higher of the university level,the richer working experiences that the senior leaders have. And the party leaders have more abundant working experience respect to the executive leaders. By the way,most of the principal leaders have the outside-system working experience and are from the external se-lection. But on the whole,internal promotion is still the main way for a leader.%以我国112所“211工程”大学的567名高层领导的履历资料为基础,对大学高层领导的群体特征进行实证分析,结果显示:(1)在人口统计学特征上,我国大学高层领导以55岁左右的汉族男性为主,越是高水平的大学,其高层领导越可能是年长者,女性难以晋升的“玻璃天花板”现象依然存在,但不存在民族歧视;(2)在学术特征上,行政领导相对于党委领导、正职领导相对于副职领导,无论是学历、职称还是国际化水平上都有着更高的要求,且理工科背景出身相比其他背景来说,担任高层领导的机会更大;(3)

  19. Up, down, strange and charm quark masses with N{sub f}=2+1+1 twisted mass lattice QCD

    Carrasco, N. [INFN, Sezione di Roma Tre, Via della Vasca Navale 84, I-00146 Rome (Italy); Deuzeman, A. [Albert Einstein Center for Fundamental Physics, Institute for Theoretical Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Dimopoulos, P. [Centro Fermi – Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Compendio del Viminale, Piazza del Viminale 1, I-00184 Rome (Italy); Dipartimento di Fisica, Università di Roma “Tor Vergata”, Via della Ricerca Scientifica 1, I-00133 Rome (Italy); Frezzotti, R. [Dipartimento di Fisica, Università di Roma “Tor Vergata”, Via della Ricerca Scientifica 1, I-00133 Rome (Italy); INFN, Sezione di “Tor Vergata”, Via della Ricerca Scientifica 1, I-00133 Rome (Italy); Giménez, V. [Departament de Física Teòrica and IFIC, Univ. de València – CSIC, Dr. Moliner 50, E-46100 València (Spain); Herdoiza, G. [PRISMA Cluster of Excellence, Institut für Kernphysik, Johannes Gutenberg-Universität, D-55099 Mainz (Germany); Lami, P.; Lubicz, V. [Dipartimento di Matematica e Fisica, Università Roma Tre, Via della Vasca Navale 84, I-00146 Rome (Italy); INFN, Sezione di Roma Tre, Via della Vasca Navale 84, I-00146 Rome (Italy); Palao, D. [Goethe-Universität, Institut für Theoretische Physik, Max-von-Laue-Straße 1, D-60438 Frankfurt am Main (Germany); and others

    2014-10-15

    We present a lattice QCD calculation of the up, down, strange and charm quark masses performed using the gauge configurations produced by the European Twisted Mass Collaboration with N{sub f}=2+1+1 dynamical quarks, which include in the sea, besides two light mass degenerate quarks, also the strange and charm quarks with masses close to their physical values. The simulations are based on a unitary setup for the two light quarks and on a mixed action approach for the strange and charm quarks. The analysis uses data at three values of the lattice spacing and pion masses in the range 210–450 MeV, allowing for accurate continuum limit and controlled chiral extrapolation. The quark mass renormalization is carried out non-perturbatively using the RI′-MOM method. The results for the quark masses converted to the MS{sup ¯} scheme are: m{sub ud}(2 GeV)=3.70(17) MeV, m{sub s}(2 GeV)=99.6(4.3) MeV and m{sub c}(m{sub c})=1.348(46) GeV. We obtain also the quark mass ratios m{sub s}/m{sub ud}=26.66(32) and m{sub c}/m{sub s}=11.62(16). By studying the mass splitting between the neutral and charged kaons and using available lattice results for the electromagnetic contributions, we evaluate m{sub u}/m{sub d}=0.470(56), leading to m{sub u}=2.36(24) MeV and m{sub d}=5.03(26) MeV.

  20. 肿瘤 M2-PK、CEA、SCC、NSE 和 CYFRA21-1在人肺癌诊断中的比较%Comparison of tumor M2-PK, CEA, SCC, NSE and CYFRA21-1 in diagnosis of lung cancer

    魏枫华; 齐川; 李满元

    2014-01-01

    Objective:To compare differences of tumor M2-PK, CEA, SCC, NSE and CYFRA21-1 in diagnosis of lung canc-er. Methods:142 cases with newly diagnosed lung cancer was recruited in the study. M2-PK was detected by an ELISA method. Re-sults: Through comparing tumor markers of human lung cancer with different histologic types, it found that M2-PK had a higher sensi-tivity (57% ) than those of CEA (38% ) and CYFRA 21-1 (43% ). In non-small cell lung cancer (NSCLC), M2-PK (59% ), CEA (39% ) and CYFRA21-1 (56% ) were more sensitive than others. However, for small cell lung cancer, NSE was more sensitive than the other tumor markers. Conclusions: M2-PK can be a better marker for the diagnosis of lung cancer.%目的:为了比较 M2-PK、CEA、CYFRA21-1、NSE 和 SCC 在人肺癌诊断中的差异。方法:142例新诊断的肺癌患者被纳入本次研究,M2-PK 是用一个灵敏的 ELISA 试剂盒来检测的。结果:通过比较不同组织类型人肺癌的肿瘤标志物,发现 M2-PK 灵敏度(灵敏度57%)比 CEA(灵敏度38%)和 CYFRA 21-1(灵敏度43%)高。在非小细胞肺癌中 M2-PK(灵敏度59%),CEA(灵敏度39%),CYFRA21-1(灵敏度56%)的灵敏度普遍较高。对于小细胞肺癌来说,NSE 比其他标志物更敏感。结论:M2-PK 可以作为检测肺癌的标志物。

  1. The value of combined detection of serum SCCA,CYFRA21-1 and CEA in diagnosis of lung cancer%血清SCCA、CYFRA21-1、CEA联合检测在肺癌诊断中的价值

    王小芳; 罗玲

    2013-01-01

    目的 评价血清鳞状细胞癌抗原(SCCA)、细胞角蛋白片段21-1(CYFRA21-1)、癌胚抗原(CEA)联合检测在肺癌诊断中的价值.方法 选择重庆市肿瘤研究所2008年1~4月住院患者共63例,收集所有患者血清检测SCCA、CYFRA21-1及CEA.其中肺癌44例,肺部良性病变者19例,肺癌患者中小细胞肺癌5例、鳞癌17例、腺癌15例,未定型肺癌7例,所有肺癌患者均为病理确诊.结果 肺癌组SCCA、CYFRA21-1、CEA水平均高于肺部良性病变组(P<0.01),在不同病理类型中,3种指标升高的程度不等,SCCA 及CYFRA21-1水平在鳞癌组最高,CEA水平在腺癌组最高,与其他组比较差异有统计学意义(P<0.01).结论 血清SCCA、CYFRA21-1、CEA检测在肺癌的诊断、病理类型的推断中具有重要意义,而联合检测更有助于肺癌的诊断.%Objective To evaluate the clinical value of combined determination of tumor markers including serum squamous cell carcinoma antigen(SCCA) ,cytokeratin 19 fragment(CYFRA21-l) , carcino-embryonic antigen(CKA) in diagnosis of lung cancer. Methods 63 cases including 44 cases of lung cancer and 19 benign lesion were collected from inpatients registered in our hospital from January to April in 2008. The lung cancer were pathologically diagnosed including 5 cases of small cell lung cancer, 17 cases of squamous cell carcinoma ,15 cases of adenocarcinoma,and 7 undecided type lung cancer. All cases were bronchoalveolar lavaged and bronchoalveolar lavage fluid were collected to prepare for detect SCCA, CYFRA21-1, CEA. Results The levels of the 3 tumor markers measured in serum were higher in lung cancer group than those in benign lung disease group(P<0. 01). The tumor markers increased to different degrees among the patients in various pathological classifications. The levels of SCCA ,CYFRA21-1 measured in serum were higher in squamous cell carcinoma group, and the levels of CEA were higher in adenocarcinoma group(P< 0. 01). Conclusion The

  2. BAC array CGH in patients with Velocardiofacial syndrome-like features reveals genomic aberrations on chromosome region 1q21.1

    Estivill Xavier

    2009-12-01

    Full Text Available Abstract Background Microdeletion of the chromosome 22q11.2 region is the most common genetic aberration among patients with velocardiofacial syndrome (VCFS but a subset of subjects do not show alterations of this chromosome region. Methods We analyzed 18 patients with VCFS-like features by comparative genomic hybridisation (aCGH array and performed a face-to-face slide hybridization with two different arrays: a whole genome and a chromosome 22-specific BAC array. Putative rearrangements were confirmed by FISH and MLPA assays. Results One patient carried a combination of rearrangements on 1q21.1, consisting in a microduplication of 212 kb and a close microdeletion of 1.15 Mb, previously reported in patients with variable phenotypes, including mental retardation, congenital heart defects (CHD and schizophrenia. While 326 control samples were negative for both 1q21.1 rearrangements, one of 73 patients carried the same 212-kb microduplication, reciprocal to TAR microdeletion syndrome. Also, we detected four copy number variants (CNVs inherited from one parent (a 744-kb duplication on 10q11.22; a 160 kb duplication and deletion on 22q11.21 in two cases; and a gain of 140 kb on 22q13.2, not present in control subjects, raising the potential role of these CNVs in the VCFS-like phenotype. Conclusions Our results confirmed aCGH as a successful strategy in order to characterize additional submicroscopic aberrations in patients with VCF-like features that fail to show alterations in 22q11.2 region. We report a 212-kb microduplication on 1q21.1, detected in two patients, which may contribute to CHD.

  3. Spatial analysis of 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (Sea-Nine 211) concentrations and probabilistic risk to marine organisms in Hiroshima Bay, Japan

    We analyzed the spatial distribution of an antifouling biocide, 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (Sea-Nine 211) in the surface water and sediments of Hiroshima Bay, Japan to determine the extent of contamination by this biocide. A quantitative estimate of the environmental concentration distribution (ECD) and species sensitivity distributions (SSDs) for marine organisms were derived by using a Bayesian statistical model to carry out a probabilistic ecological risk analysis, such as calculation of the expected potentially affected fraction (EPAF). The spatial distribution analysis supported the notion that Sea-Nine 211 is used mainly for treatment of ship hulls in Japan. The calculated EPAF suggests that approximately up to a maximum of 0.45% of marine species are influenced by the toxicity of Sea-Nine 211 in Hiroshima Bay. In addition, estimation of the ecological risk with a conventional risk quotient method indicated that the risk was a cause for concern in Hiroshima Bay. - Highlights: • Spatial distribution analysis exhibits the dynamics of Sea-Nine 211 in Hiroshima Bay. • Probabilistic ecological risk of the biocide was estimated with a Bayesian approach. • Approximately up to 0.45% of marine species were possibly influenced by the toxicity. • The risk analysis concludes that Sea-Nine 211 should be a priority for further work. - Spatial distribution of an antifouling biocide and quantification of its ecological risk were elucidated

  4. Diagnostic value of Cyfra21-1, SCC and CEA for differentiation of early-stage NSCLC from benign lung disease

    Chen, Feng; Wang, Xiu-Ying; Han, Xiao-Hong; Wang, Hai; Qi, Jun

    2015-01-01

    Non-small cell lung cancer (NSCLC), which account for the most of lung carcinoma, is sometimes difficult to differentiate from benign lung diseases presented with nodular shadow in imaging scan. There is a need to find another non-invasive way to diagnosis early-stage NSCLC. To examine the potential diagnostic value of SCC, CFYRA 21-1 and CEA for the differentiation of early-stage NCSCL from benign lung diseases, we analyzed serum levels of tumor markers in 278 patients, including 248 patient...

  5. FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimüllerian hormone in healthy girls

    Hagen, Casper P; Aksglæde, Lise; Sørensen, Kaspar; Mouritsen, Annette; Mieritz, Mikkel G; Main, Katharina M; Petersen, Jørgen Holm; Almstrup, Kristian; Rajpert-De Meyts, Ewa; Anderson, Richard A; Juul, Anders

    2013-01-01

    To investigate whether genetic polymorphisms in the FSH pathway (FSHB-211 G→T and FSHR 2039 A→G) affect serum levels of FSH, antimüllerian hormone (AMH), and age at pubertal onset. FSH secretion and FSH signal transduction are enhanced in carriers of FSHB GG and FSHR AA, respectively. Furthermore......, the combined genotype FSHB GG+FSHR AA is the most favorable for male gonadal function, but the effect of this genotype has never been evaluated in peripubertal females. AMH is a marker of ovarian function and is negatively correlated with FSH in prepubertal girls....

  6. Approaching the QCD phase diagram for N_f=2+1 and N_f=2+1+1 quark flavors

    Welzbacher, Christian A; Luecker, Jan

    2014-01-01

    Recent results for the QCD phase structure at finite temperature and light-quark chemical potential are summarized, where the cases of N_f = 2 + 1 and N_f = 2+1+1 dynamical quark flavors are considered. Order parameters for the chiral and deconfinement transitions are obtained from solutions of a coupled set of truncated Dyson-Schwinger equations for the quark and gluon propagators of Landau gauge QCD. Based on very good agreement with lattice QCD for zero chemical potential the phase diagram in the whole T-\\mu-plane and the appearance of a putative critical end-point at large chemical potential are studied.

  7. RI/MOM renormalization constants (N_f=4) and the strong coupling constant (N_f=2+1+1) from twisted-mass QCD

    Blossier, B; Brinet, M; De Soto, F; Du, X; Gravina, M; Liu, Z; Morenas, V; Pène, O; Petrov, K; Rodríguez-Quintero, J

    2011-01-01

    We study RI/MOM renormalization constants of bilinear quark operators for $N_f=4$ and the strong coupling constant for $N_f=2+1+1$ using Wilson twisted-mass fermions. We use the "egalitarian" method to remove H(4) hypercubic artifacts non-perturbatively, which enables us to study physical quantities in a wide range of momenta. We then apply OPE in studying the running behavior of $Z_q$ and $\\alpha_s$, from which we are able to extract the Landau gauge dimension-two gluon condensate $$ which is of phenomenological interest.

  8. Value of tumor markers in differential diagnosis of malignant hydrothorax%CEA、CYFRA 21-1对肺非小细胞性恶性胸腔积液诊断价值的研究

    张益辉; 王泽球; 张庆文

    2007-01-01

    目的 观察胸水及血清CEA、CYFRA21-1测定值对非小细胞性恶性胸腔积液的诊断价值.方法 测定本院145例胸腔积液病人的血清及胸水CEA、CYFRA21-1,按良恶性分为两组,并行统计分析.结果 胸水及血清CEA、CYFRA21-1测定值,在两组之间有非常显著差异.结论 血及胸水肿瘤标记物测定可作为胸腔积液病人检测的一个常规项目,对恶性胸腔积液有较高的诊断价值.

  9. Systemic radioimmunotherapy using a monoclonal antibody, anti-Tac directed toward the alpha subunit of the IL-2 receptor armed with the {alpha}-emitting radionuclides {sup 212}Bi or {sup 211}At

    Wesley, Jon N.; McGee, Edwin C.; Garmestani, Kayhan; Brechbiel, Martin W.; Yordanov, Alexander T.; Wu Chuanchu; Gansow, Otto A.; Eckelman, William C.; Bacher, John D.; Flynn, Michael; Goldman, Carolyn K.; MacLin, Melvin; Schwartz, Uwe P.; Jackson-White, Terri; Phillip, Celeste M.; Decker, Jean; Waldmann, Thomas A. E-mail: tawald@helix.nih.gov

    2004-04-01

    To exploit the fact that IL-2 receptors are expressed by T-cells responding to foreign antigens but not by resting T-cells, humanized anti-Tac (HAT) armed with alpha-emitting radionuclides {sup 212}Bi and {sup 211}At was evaluated in a cynomolgus cardiac allograft model. Control graft survival was 8.2{+-} 0.5 days compared with 14.0{+-}1.3 days (p<0.01) survival for monkeys treated with {sup 212}Bi labeled HAT and 26.7{+-}2.4 days survival (p<0.001 versus controls) with {sup 211}At labeled HAT. Thus, {sup 211}At labeled HAT may have application in organ transplantation and in treatment of IL-2 receptor expressing T-cell leukemia.

  10. The diagnostic value for combination of 4 serum tumor markers CEA ,NSE, CYFRA21-1 and SCC-Ag in lung cancer%CEA、NSE、CYFRA21-1、SCC-Ag在肺癌诊断中的价值研究

    叶雅丽; 闫李侠; 阮荣华

    2012-01-01

      Objective :To investigate the clinical diagnosis value in lung cancer to combine four serum tumor marker CEA ,NSE, CYFRA21-1 and SCC-Ag .Methods : To analyze retrospectively the diagnosis sensitivity of CYFRA21-1 ,CEA ,NSE and SCC in 115 cases with lung cancer,58 with being lung diseases and 90 healthy controls .Results : The serum tumor marker levels in the lung cancergroup were significantly higher than those in benign lung disease group and control group (P<0.01);These four TM combinations may be more sensitive in the diagnosis of lung cancer(P <0.05) .Conclusion : Combination of four serum tumor marker CEA ,NSE, CYFRA21-1 and SCC-Ag markers can increase the clinical diagnosis value in lung cancer .%  目的探讨血清肿瘤标志物癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)、鳞状上皮细胞癌抗原(SCC-Ag)单独或联合检测对肺癌的诊断价值.方法测定115例肺癌患者、58例肺良性疾病患者及健康对照者90例四种血清肿瘤标志物的含量水平,并计算各项目阳性率.结果肺癌组4项肿瘤标志物水平显著高于健康组和肺良性疾病组及健康对照组(P<0.01);4项标志物联合检测对肺癌的敏感性和准确性均高于单项检测(P<0.05).结论 CEA、NSE 、CYFRA21-1、SCC-Ag 4项肿瘤标志物对肺癌的诊断具有较大的辅助诊断价值,联合检测可提高检出率.

  11. 血清CEA,CA125,NSE,CYFRA21-1联合检测对肺癌的诊断价值%Diagnostic Value of Combined Determination of Serum Tumor Markers (CEA, CA 125, NSE, CYFRA 21-1 ) Levels in Patients with Lung Cancer

    黄芳; 耿燕; 李婷婷; 张西英

    2008-01-01

    目的 探讨血清癌胚抗原(CEA)、糖类抗原125(CA125)、细胞角蛋白片段21-1(CYFRA21-1)、神经元特异性烯醇化酶(NSE)联合检测对肺癌的诊断价值.方法 采用电化学发光法对78例肺癌(其中鳞癌30例,腺癌28例,小细胞癌20例)、45例肺部良性病患者和36例健康人血清进行分析.结果 肺癌患者血清4种肿瘤标志物含量明显高于肺部良性疾病组(P<0.05)和健康对照组(P<0.01).肺癌组经病理分型后,NSE在小细胞肺癌中的水平明显高于其他类型的肺癌(P<0.05);CYFRA21-1的水平在鳞癌中升高尤为明显(P<0.05);CEA的水平在腺癌中显著升高(P<0.05).4种肿瘤标志物单项检测时,特异度较高(82.22%~95.56%),但敏感度不是很高(38.46%~56.41%).联合检测后,可提高肺癌的阳性检出率(64.10%).结论 CEA,CA125,NSE和CYFRA21-1对肺癌有一定的辅助诊断价值,且CEA,NSE和CYFRA21-1对不同组织类型肺癌均有一定诊断价值,联合检测可提高对肺癌的阳性诊断.

  12. Final Report for research grant entitled "Development of Reagents for Application of At-211 and Bi-213 to Targeted Radiotherapy of Cancer"

    Wilbur, D. Scott

    2011-12-23

    This grant was a one-year extension of another grant with the same title (DE-FG03-98ER62572). The objective of the studies was to continue in vivo evaluation of reagents to determine which changes in structure were most favorable for in vivo use. The focus of our studies was development and optimization of reagents for pretargeting alpha-emitting radionuclides At-211 or Bi-213 to cancer cells. Testing of the reagents was conducted in vitro and in animal model systems. During the funding period, all three specific aims set out in the proposed studies were worked on, and some additional studies directed at development of a method for direct labeling of proteins with At-211 were investigated. We evaluated reagents in two different approaches in 'two step' pretargeting protocols. These approaches are: (1) delivery of the radionuclide on recombinant streptavidin to bind with pretargeted biotinylated monoclonal antibody (mAb), and alternatively, (2) delivery of the radionuclide on a biotin derivative to bind with pretargeted antibody-streptavidin conjugates. The two approaches were investigated as it was unclear which will be superior for the short half-lived alpha-emitting radionuclides.

  13. K^0-\\bar{K}^0 mixing in the Standard Model from Nf=2+1+1 Twisted Mass Lattice QCD

    Carrasco, N; Dimopoulos, P; Frezzotti, R; Palao, D; Rossi, G C; Lubicz, V; Papinutto, M; Sanfilippo, F; Simula, S

    2011-01-01

    We present preliminary results at {\\beta} = 1.95 (a = 0.077 fm) on the first unquenched N_f=2+1+1 lattice computation of the B_K parameter which controls the neutral kaon oscillations in the Standard Model. Using N_f=2+1+1 maximally twisted sea quarks and Osterwalder-Seiler valence quarks we achieve O(a) improvement and a continuum-like renormalization pattern for the four-fermion operator. Our results are extrapolated/interpolated to the physical light/strange quark mass but not yet to the continuum limit. The computation of the relevant renormalization constants is performed non perturbatively in the RI'-MOM scheme using dedicated simulations with N_f=4 degenerate sea quark flavours produced by the ETM collaboration. We get B_K^{RGI} (a = 0.077) = 0.747(18), which when compared to our previous unquenched N_f=2 determination and most of the existing results, suggests a rather weak B_K^{RGI} dependence on the number of dynamical flavours. We are at the moment analysing lattice data at two additional {\\beta} v...

  14. Prognostic value of CYFRA 21-1 and CEA in patients with undifferentiated nasopharyngeal carcinoma before and after radiotherapy%鼻咽未分化癌患者放疗前后血清人细胞角蛋白21-1片段和癌胚抗原水平与预后的关系

    朱婉琦; 孙新东; 谢鹏; 孔莉; 于金明

    2011-01-01

    Objective The purpose of this study was to evaluate the potential of CYFRA 21-1 (CYFRA) and CEA as a prognostic marker in patients with undifferentiated nasopharyngeal carcinoma ( NPC). Methods From March 2004 to February 2008, 62 patients with newly diagnosed, undifferentiated NPC were treated in our department. Their clinocopathological data were analyzed retrospectively. All patients received intensity-modulated radiotherapy using 6 MV X-rays, and serum CYFRA and CEA before and after radiotherapy were assayed. The association among the long-term follow-up results and age, sex, smoke, TNM stage, chemotherapy, CEA, CYFRA and the changes in any direction of serum CYFRA and CEA were determined. Results Patients with low pre-RT level ( ≤ 2. 49μg/L) of CYFRA had a significantly better overall survival ( OS) than patients with high level ( > 2. 49 μg/L,OR = 8. 555, P = 0.029). N classification and T classification were positively associated with the prediction of progression free survival ( OR = 4. 054, P = 0. 001; OR = 3. 873, P = 0. 001 ). But there was no significant association between the rest predictors (age, sex, CEA, post-RT CYFRA, chemotherapy and a radiation-induced decrease in serum markers) and the survival or recurrence rate by multivariate analysis. Conclusions The results of the present study show that pre-RT serum CYFRA level is a valuable factor for predicting long-term survival in patients with undifferentiated nasopharyngeal carcinoma. More aggressive treatment may be given to those patients with a high serum CYFRA level.%目的 研究鼻咽未分化癌患者放疗前后血清人细胞角蛋白21-1片段(CFRA21-1)和癌胚抗原(CEA)水平与预后的关系.方法 回顾性分析2004年5月至2008年2月月随访资料完整、并经病理学确诊为无远处转移的62例鼻咽未分化癌患者的临床资料.所有患者均采用6MV X线调强放疗,分析放疗前后CYFBA21-1及CEA水平与患者预后的关系.结果 放疗前CYFRA21-1

  15. CYFRA 21-1 as an early predictor of first line chemotherapy response in advanced non small cell lung cancer%Cyfra21-1对进展期非小细胞肺癌一线化疗疗效的早期预测作用

    Kashif Iqbal; Yuan Chen; Mengxian Zhang; Qian Chu

    2007-01-01

    Objective:In an era of ever evolving,promising new therapies for advanced non small celllung cancer(NSCLC),early predictors of response to therapy.are needed.We evaluated early variations in CYFRA 21-1 serum levels of patients with advanced NSCLC receiving first line chemotherapy and correlated the results with objective tumor response.Methods:29 consecutive.previously untreated.patients of advanced non small cell lung cancer,with measurable disease On CT scan were evaluated.All patients were treated with conventional systemic chemotherapy,although the choice of chemotherapy was left to the discretion of the treating physicians.Serum samples were obtained immediately before the start of 1st and 2nd cycles of chemotherapy.CYFRA 21-1 was measured with an electrochemlluminescense immunoassay on an automatic analyzer (Elecsys 2000;Roche Diagnostics).Response was evaluated using Response evaluation criteria in solid tumors (RECIST)criteria.Result:10 patients had partial response,9 patients had stable disease and 9 had progressive disease.None of the patients had complete response.21/29(72%)patients had an elevated baseline value of CYFRA 21-1.62%patients(18/29)had a decrease in CYFRA21-1 after 1 cycle of chemotherapy.The average reduction in the 2nd reading was irrespective of whether baseline value was normal or not.The average reduction was statistically significant(P=0.002;95%CI,from 0.8369 to 3.49464;t test).8 out of 10(80%)patients with partial response had a reduction in their 2nd reading of.CYFRA (P=0.019:95%CI,from 0.81965 to 7.20035;t test)which was significant.We also observed that 6/9 (66%)patients whose disease remains stable also had a decrease in their subsequent reading(P=0.0106;95%CI.from-0.44942 to 3.82720;t test),though it was not significant statistically.Although 5 out of 9(55%)patients,who had an increase in their CYFRA 21-1 level,had progressive disease,but it was not statistically significant(P=0.537;95%CI,from-1.20021 to 2.13354;t test).14 out of

  16. 玻璃体腔注射大麻素 HU-211治疗鼠青光眼视神经损伤的研究%Clinical study on intravitreal injection of cannabinoid HU - 211 for optic nerve damage in glaucoma rats

    刘慧峰; 何媛; 贾俊; 姬明利; 席进伟

    2014-01-01

    目的:评价玻璃体腔内注射大麻素 HU-211对大鼠青光眼模型视神经的保护作用,为青光眼视神经损伤治疗提供实验依据。  方法:采用电凝巩膜表面静脉法制作大鼠青光眼模型18眼,随机分为3组:A 组分别隔日一次玻璃体腔注射1mg/0.1mL大麻素 HU-211,B 组隔日一次玻璃体腔注射0.1mL 生理盐水,C 组为高眼压组。随机选6只对侧眼为空白对照组,每日观察眼压变化情况,用药4wk 后处死大鼠,视网膜冰冻切片,HE 染色通过视网膜神经元的密度变化评估大鼠慢性高眼压模型视网膜神经元的损伤程度。  结果: B 组的凋亡程度及 RGC 的损伤程度明显高于 A组,差异有统计学意义( P0.05)。  结论:玻璃体腔注射大麻素(HU-211)对大鼠青光眼模型视神经视网膜有明显的保护作用。%To evaluate the protective effects of intravitreal injection of cannabinoid HU - 211 for optic nerve in glaucoma rats, providing the experimental evidence in the treatment of glaucoma optic nerve injury. ●METHODS: Glaucoma rats (18 eyes) were modeled by electric coagulation sclera surface vein and randomized into 3 groups, group A received intravitreal injection of 1mg/ 0. 1mL cannabinoid HU - 211 every other day respectively; group B was given intravitreal injection of 0. 1mL water every other day, group C was high intraocular pressure (lOP) group, 6 eyes were randomly selected for blank control group ( group D). lOP was observed every day. The rats were sacrificed after treatment 4wk, froze retina section, HE stain. The density fluctuation of retinal ganglion cell ( RGC ) neurons assessment the optic nerve of rat model with chronic high lOP glaucoma were measured. ●RESULTS: The apoptosis and damage degree of RGC in group B was obviously higher than that in group A, with statistically significant difference (P0. 05). ●CONCLUSlON: lntravitreal injection of cannabinoid HU-211 shows obvious protective effect

  17. 外周血Cyfra21-1、NSE和Ferritin联合检测对肺癌的诊断价值%Significance of Combined Detection of Serum Cyfra21-1 and NSE and Ferritin in Diagnosis of Lung Cancer

    吴兴平; 陈浩; 刘晓华; 曾秋耀; 戴淑琴

    2010-01-01

    目的 评价外周血细胞角蛋白19片段(Cyfra21-1)、神经元特异性烯醇化酶(NSE)和铁蛋白(Ferritin)联合检测对肺癌的诊断价值.方法 采用电化学发光免疫分析法测定168例肺癌患者、60例良性肺部疾病患者和50例健康体检者外周血的Cyfra21-1、NSE和Ferritin的水平.采用t检验和x2检验进行数据统计分析.结果 肺癌组Cyfra21-1、NSE、Ferritin的水平及阳性率[分别为(15.5±10.1)ng/ml与70.2%,(39.6±13.1)ng/ml与39.9%,(1323.5±861.4)ng/ml与64.9%]明显高于良性肺部疾病组[分别为(9.4±5.6)ng/ml与25.0%,(23.6±8.2)ng/ml与18.3%,(642.4±234.6)ng/ml与34.7%]和健康对照组[分别为(5.9±1.2)ng/ml与10.0%.(18.3±1.8)ng/ml与10.0%,(544.6±135.4)ng/ml与16..结论 %](P<0.01).随着临床分期逐渐升高,cyfra21-1、NSE、Ferritin的阳性率和水平也有不同程度升高.就组织类型而言,Cyfra21-1检测阳性率和表达水平以鳞癌较高.NSE的阳性率和表达水平以小细胞癌最高,而Ferritin的阳性率和表达水平则差异不显著.三项联合检测灵敏度达91.1%,与二项或单项比较差异有统计学意义(P<0.05).结论 外周血Cyfra21-1、NSE和Ferritin联合检测可提高肺癌检出率及对肺癌组织类型鉴别诊断具有重要临床意义.

  18. Clinical significance of CYFRA21-1 and CEA in the early prognosis of patients with locally advanced non-small cell lung cancer%CYFRA21-1和CEA对局部晚期非小细胞肺癌患者早期预后的意义

    张丽娜; 么建立; 郝殿晋; 李洪臣; 王术艺; 张庆波

    2013-01-01

    Objective: To investigate the value of evaluation indicators of carcinoembryonic antigen (CEA) and cy-tokeratin 19 fragment( CYFRA21 - 1) as short - term efficacy in patients with advanced non - small cell lung cancer (NSCLC). Methods: The level of serum CEA and CYFRA21 - 1 were detected by electrochemoluminescence immu-noassay in 85 patients with locally advanced non - small cell lung cancer. All statistical analyses were done with software of SPSS14.0. Results:The level of CYFRA21 - 1 and CEA was associated with the therapeutic effect. The level of CEA and CYFRA21 - 1 of patients achieving partial remission (PR) or complete remission ( CR) after treatment were decreased significantly; On the contrary, the level of CEA and CYFRA21 - 1 of patients achieving SD or PD were basically stable or increased. In a multivariate analysis , the level of CEA and CYFRA21 - 1 after one cycle of chemotherapy were confirmed as independent prognostic factors for therapeutic effect. Conclusion; The level of CY-FRA21 - 1 and CEA are associated with the therapeutic effect. Patients may get better prognosis with the decreasing of serum tumor marker level. The level of CEA and CYFRA21 - 1 after one cycle of chemotherapy are confirmed as independent prognostic factors for therapeutic effect.%目的:研究癌胚抗原(CEA)和细胞角蛋白19片段(CYFRA21-1)作为晚期非小细胞肺癌(NSCLC)短期疗效评价指标的价值.方法:采用电化学发光法测定85例初治的局部晚期NSCLC患者化疗前后血清中CEA、CYFRA21-1的水平,所有统计应用SPSS14.0统计软件进行分析.结果:化疗前CEA、CYFRA21-1在治疗有效组(CR+ PR)和无效组(SD+ PD)的分布无显著性差异.二者的水平在治疗有效组的化疗后明显低于化疗前,比较有显著性差异;在无效组化疗后的表达水平高于化疗前,但比较无显著性差异.多因素分析显示化疗前低水平的血清CEA、CYFRA21-1是近期疗效的保护性因素,化疗

  19. The bicyclo[2.1.1]hexan-2-one system: a new probe for the experimental and computational study of electronic effects in pi-facial selectivity in nucleophilic additions

    Mehta, Goverdhan; Singh, Robindro S; Gagliardini, Vanessa; Priyakumar, Deva U; Sastry, Narahari G.

    2001-01-01

    The remotely substituted 5-exo-bicyclo[2.1.1]hexan-2-one system is introduced as a new probe to study long range electronic effects on pi-face selectivity during hydride reduction and a systematic computational study demonstrates good predictability at the semi-empirical level.

  20. Correlation between phonon anomaly along [211] and the Fermi surface nesting features with associated electron-phonon interactions in Ni{sub 2}FeGa: A first principles study

    Chabungbam, Satyananda; Sahariah, Munima B., E-mail: munima@iasst.gov.in

    2015-10-25

    First principles calculation reaffirms the presence of phonon anomaly along [211] direction in Ni{sub 2}FeGa shape memory alloy supporting the experimental findings of J. Q. Li et al. Fermi surface scans have been performed in both austenite and martensite phase to see the possible Fermi nesting features in this alloy. The magnitude of observed Fermi surface nesting vectors in (211) plane exactly match the phonon anomaly wavevectors along [211] direction. Electron-phonon calculation in the austenite phase shows that there is significant electron-phonon coupling in this alloy which might arise out of the lattice coupling between lower acoustic modes and higher optical modes combined with the observed strong Fermi nesting features in the system. - Highlights: • Transverse acoustic (TA{sub 2}) modes show anomaly along [211] direction in Ni{sub 2}FeGa. • The phonon anomaly wavevector has been correlated with the Fermi nesting vectors. • Electron-phonon coupling calculation shows significant coupling in this system. • Max. el-ph coupling occurs in transition frequencies from acoustic to optical modes.

  1. Secret World of the Forbidden City: Splendors from Imperial China, 1644-1911 and Change and Continuity: Chinese Americans in California. Exhibition Information and Curriculum Guide for Teachers Grades 2-11.

    2000

    The materials in this curriculum guide were designed to prepare teachers and students in grades 2-11 for the "Secret World of the Forbidden City: Splendors from China's Imperial Palace 1644-1911" exhibition at the Oakland Museum of California Education Department, to inform teachers and students about Imperial China, and to illuminate the…

  2. Avaliação dos valores sérico e pleural dos marcadores tumorais CEA, CYFRA21-1 e CA 15-3 em portadores de derrame pleural Evaluation of serum and pleural levels of the tumor markers CEA, CYFRA21-1 and CA 15-3 in patients with pleural effusion

    Isabella Coimbra Wagner; Murilo José de Barros Guimarães; Lilian Karine Neves da Silva; Francisco Montenegro de Melo; Maria Tereza Cartaxo Muniz

    2007-01-01

    OBJETIVO: Dosar os marcadores tumorais antígeno carcinoembrionário (CEA), fragmento da citoqueratina 19 (CYFRA21-1) e antígeno glicosídico associado a tumor 15-3 (CA 15-3) em sangue e líquido pleural de portadores de derrames pleurais benignos e malignos, avaliando a sensibilidade de cada um deles nesses fluidos. MÉTODOS: Avaliamos prospectivamente 85 pacientes com derrame pleural. O estudo do líquido pleural obedeceu a critérios determinados pela literatura. A dosagem dos marcadores foi real...

  3. Absorbed Doses and Risk Estimates of (211)At-MX35 F(ab')2 in Intraperitoneal Therapy of Ovarian Cancer Patients

    Cederkrantz, Elin; Andersson, Håkan; Bernhardt, Peter;

    2015-01-01

    , intraperitoneal (i.p.) targeted α therapy has been proposed as an adjuvant treatment for minimal residual disease after successful primary treatment. In the present study, we calculated absorbed and relative biological effect (RBE)-weighted (equivalent) doses in relevant normal tissues and estimated the effective...... infused therapy solution. RESULTS: The urinary bladder, thyroid, and kidneys (1.9, 1.8, and 1.7 mGy per MBq/L) received the 3 highest estimated absorbed doses. When the tissue-weighting factors were applied, the largest contributors to the effective dose were the lungs, stomach, and urinary bladder. Using...... 100 MBq/L, organ equivalent doses were less than 10% of the estimated tolerance dose. CONCLUSION: Intraperitoneal (211)At-MX35 F(ab')2 treatment is potentially a well-tolerated therapy for locally confined microscopic ovarian cancer. Absorbed doses to normal organs are low, but because the effective...

  4. Mapping of the thermal neutron distribution in the lead block assembly of the PS-211 experiment at CERN, using thermoluminescence and nuclear track detectors

    Savvidis, E; Kitis, G

    2002-01-01

    The main purpose of the TARC (transmutation by adiabatic resonance crossing) experiment (PS-211), was to demonstrate the possibility to destroy efficiently long-lived fission fragments (LLFF) in accelerator driven systems (ADS). The experimental set-up which consisted of a lead block with dimensions 3.3 * 3.3 * 3 m/sup 3/, was installed in a CERN proton synchrotron (PS) beam line. The proton beam at 2.5 GeV/c and 3.5 GeV/c, was incident in the centre of the lead block assembly producing neutrons via spallation reactions. Neutron flux measurements are presented in the lead block assembly using thermoluminescence and nuclear track detectors. The results are in good agreement with Monte Carlo calculations as well as with the results of the other methods used in the framework of the TARC experiment. (5 refs).

  5. Detection of chloronium and measurement of the 35Cl/37Cl isotopic ratio at z=0.89 toward PKS1830-211

    Muller, S; Guelin, M; Henkel, C; Combes, F; Gerin, M; Aalto, S; Beelen, A; Darling, J; Horellou, C; Martin, S; Menten, K M; Dinh-V-Trung,; Zwaan, M A

    2014-01-01

    We report the first extragalactic detection of chloronium (H2Cl+), in the z=0.89 absorber in front of the lensed blazar PKS1830-211. The ion is detected through its 1_11-0_00 line along two independent lines of sight toward the North-East and South-West images of the blazar. The relative abundance of H2Cl+ is significantly higher (by a factor ~7) in the NE line of sight, which has a lower H2/H fraction, indicating that H2Cl+ preferably traces the diffuse gas component. From the ratio of the H2^35Cl+ and H2^37Cl+ absorptions toward the SW image, we measure a 35Cl/37Cl isotopic ratio of 3.1 (-0.2; +0.3) at z=0.89, similar to that observed in the Galaxy and the solar system.

  6. Cavity residue leucine 95 and channel residues glutamine 204, aspartic acid 211, and phenylalanine 269 of toluene o-xylene monooxygenase influence catalysis.

    Kurt, Cansu; Sönmez, Burcu; Vardar, Nurcan; Yanık-Yıldırım, K Cansu; Vardar-Schara, Gönül

    2016-09-01

    Structural analysis of toluene-o-xylene monooxygenase (ToMO) hydroxylase revealed the presence of three hydrophobic cavities, a channel, and a pore leading from the protein surface to the active site. Here, saturation mutagenesis was used to investigate the catalytic roles of alpha-subunit (TouA) second cavity residue L95 and TouA channel residues Q204, D211, and F269. By testing the substrates toluene, phenol, nitrobenzene, and/or naphthalene, these positions were found to influence the catalytic activity of ToMO. Several regiospecific variants were identified from TouA positions Q204, F269, and L95. For example, TouA variant Q204H had the regiospecificity of nitrobenzene changed significantly from 30 to 61 % p-nitrophenol. Interestingly, a combination of mutations at Q204H and A106V altered the regiospecificity of nitrobenzene back to 27 % p-nitrophenol. TouA variants F269Y, F269P, Q204E, and L95D improved the meta-hydroxylating capability of nitrobenzene by producing 87, 85, 82, and 77 % m-nitrophenol, respectively. For naphthalene oxidation, TouA variants F269V, Q204A, Q204S/S222N, and F269T had the regiospecificity changed from 16 to 9, 10, 23, and 25 % 2-naphthol, respectively. Here, two additional TouA residues, S222 and A106, were also identified that may have important roles in catalysis. Most of the isolated variants from D211 remained active, whereas having a hydrophobic residue at this position appeared to diminish the catalytic activity toward naphthalene. The mutational effects on the ToMO regiospecificity described here suggest that it is possible to further fine tune and engineer the reactivity of multicomponent diiron monooxygenases toward different substrates at positions that are relatively distant from the active site. PMID:27311562

  7. The clinical value of 99Tcm-HL91 hypoxia imaging combined with the detection of serum NSE, CEA and CYFRA21-1 in the diagnosis of lung cancer

    Objective: To investigate the value of 99Tcm-HL91 hypoxia imaging combined the detection of serum neuron-specific enolase (NSE), carcinoembryonic antigen(CEA) and cytokeratin 19 fragment (CYFRA21-1) in the diagnosis of lung cancer. Methods: 63 patients with lung neoplasm were carried out 99Tcm-Hail hypoxia imaging, and the serum tumor markers levels of Nose, Cea and CYFRA21-1 were detected. The sensitivity, specificity and accuracy of each and combined method were calculated respectively and compared with each other. Results: The sensitivity,specificity and accuracy in diagnosis of lung cancer with 99Tcm-HL91 hypoxia imaging were 85.4%, 100% and 88.9% respectively; and with serum tumor markers NSE, CEA and CYFRA21-1 detection were 72.9%, 86.7% and 76.1% respectively. Compared with the detection of serum tumor marker levels of NSE, CEA and CYFRA21-1, 99Tcm-HL91 hypoxia imaging had the higher sensitivity and specificity,and similar accuracy. The sensitivity, specificity and accuracy of combined two methods in diagnosis of lung cancer were 95.8%, 86.7% and 93.6% respectively. The sensitivity and accuracy of the combined method were significantly increased than single method (P0.05). Conclusion: 99Tcm-HL91 hypoxia imaging and the detection of serum level of NSE, CEA and CYFRA21-1 have an important diagnostic value, and their combination could improve the sensitivity and accuracy in the diagnosis of lung cancer. (authors)

  8. The identification of soil radionuclides in the area of Puspiptek and surrounding

    The area of PUSPIPTEK and the surrounding are potentially exposed by radionuclides, because the operation of the nuclear research plant. The PPTN Serpong was operated long than 10 years, therefore soil radioactivity need to evaluate. The determination of radioactivity in the soil samples which be taken from research location using gamma spectrometry on June-August. The result of the research identified natural radionuclides K-40; Thorium decay series Ac-228, Bi-212, Pb-212, Tl-208, Ra-224 and Rn-220; Uranium decay series Bi-214, Pa-234, Pb-214 and Actinium decay series Bi-211, Po-211. There are no identification radionuclides produce from the activation of PPTN Serpong

  9. 211 undergraduate college students volunteer service under the vision of ideological and political education work%思想政治教育工作视野下的211本科院校大学生志愿服务

    宝月

    2015-01-01

    大学生志愿服务是思想政治教育的重要载体,能够使学生在服务社会的过程中,提升社会责任感,并提高自身素养。然而当前211高校的志愿服务组织存在管理松散、资金缺乏等现实问题,本文着力探讨提高大学生志愿服务组织管理水平、加强人员培训等有效措施,以提升大学生志愿服务活动的思想政治教育价值。%College students’ volunteer service is the important carrier of ideological and political education, to make students in the process of social service, improve social responsibility, and improve their quality. However, the current management loose 211 colleges and universities of voluntary service organizations, the practical problems such as lacking funds etc, this article emphatically discussed to improve the college students volunteer service organization management level, strengthen personnel training and effective measures, to improve the ideological and political education of college students volunteer service activities.

  10. Diagnostic Value of Single and Combined Determination of Serum TPS Cyfra21-1 and Ferritin in patients with NSCLC%血清肿瘤标记物对非小细胞肺癌的诊断价值

    刘广军; 谢宗涛

    2012-01-01

    Objective: To investigate the diagnostic value of single and combined determination of serum tissue polypeptide specific antigen( TPS ), cytokeratin 19 fragment(Cyfra21-1 ) and ferritin in patients with non-small cell lung cancer( NSCLC ). Method: The levels of serum TPS were detected in 108 patients with NSCLC and 86 cases of healthy adults by enzyme-linked immunosorbent assay( ELASA ),and the levels of Cyfra21-1 and ferritin were detected by electrochemiluminescence. Result: The serum levels and positive rates of the three tumor markers in lung cancer group were significantly higher than those in healthy adults( P <0. 01 ). TPS showed higher sensitivity than the other two tumor markers in the diagnosis of pulmonary ade-nocarcinoma( P<0. 05 );The serum levels and positive rates of Cyfra21-1 in squamous carcinoma group were significantly higher than those in adenocarcinoma group( P<0. 01 ). TPS showed the highest sensitivity and Cyfra21-1 showed the highest sensitivity in single tumor marker detection; Their combined detection could reduce the specificity to a certain extent,but could significantly improve the sensitivity and the accuracy( P< 0. 01 ). Conclusion: The single and combined detection TPS,cyfra21-l and ferritin has high clinical value in the diagnosis of NSCLC and the differentiation of pathology types.%目的 探讨血清组织多肽特异性抗原( TPS)、细胞角蛋白19片段(Cyfra21-1)和铁蛋白(Ferritin)单项及联合检测对非小细胞肺癌的诊断价值.方法 采用酶联免疫吸附(ELISA)法测定108例NSCLC患者和86例健康人的血清中TPS水平,同时用电化学发光法测定Cyfra21-1和Ferritin水平.结果 肺癌组三项血清肿瘤标记物水平及阳性率均显著高于健康对照组(P<0.01).TPS诊断肺腺癌的敏感性优于其他两项肿瘤标记物(P<0.05);Cyfra21-1在鳞癌组血清浓度及阳性率明显高于腺癌组(P<0.01).三项肿瘤标记物单项检测时,TPS的敏感性最高,Cyfra21-1的特异性

  11. Detection of HF Toward PKS 1830–211, Search for Interstellar H2F+, and Laboratory Study of H2F+ and H2Cl+ Dissociative Recombination

    Kawaguchi, K.; Muller, S.; Black, J. H.; Amano, T.; Matsushima, F.; Fujimori, R.; Okabayahsi, Y.; Nagahiro, H.; Miyamoto, Y.; Tang, J.

    2016-05-01

    We report extragalactic observations of two fluorine-bearing species, hydrogen fluoride (HF) and fluoronium (H2F+), in the z = 0.89 absorber in front of the lensed blazar PKS 1830‑211 with the Atacama Large Millimeter/submillimeter Array. HF was detected toward both southwest and northeast images of the blazar, with column densities >3.4 × 1014 cm‑2 and 0.18 × 1014 cm‑2, respectively. H2F+ was not detected, down to an upper limit (3σ) of 8.8 × 1011 cm‑2 and an abundance ratio of [H2F+]/[HF] ≤slant 1/386. We also searched for H2F+ toward the Galactic sources NGC 6334 I and W51C, and toward Galactic center clouds with the Herschel HIFI spectrometer.6 The upper limit on the column density was derived to be 2.5 × 1011 cm‑2 in NGC 6334 I, which is 1/68 of that for H2Cl+. In constrast, the ortho transition of H2Cl+ is detected toward PKS 1830–211. To understand the small abundance of interstellar H2F+, we carried out laboratory experiments to determine the rate constants for the ion–electron recombination reaction by infrared time-resolved spectroscopy. The constants determined are k e (209 K) = (1.1+/- 0.3)× {10}-7 cm3 s‑1 and (0.46+/- 0.05)× {10}-7 cm3 s‑1 for H2F+ and H2Cl+, respectively. The difference in the dissociative recombination rates between H2F+ and H2Cl+ by a factor ∼2 and the cosmic abundance ratio [F]/[Cl] ≈ 1/6 are not enough to explain the much smaller abundance of H2F+. The difference in the formation mechanism of H2F+ and H2Cl+ in interstellar space would be a major factor in the small abundance of H2F+.

  12. The Johnson Space Center Management Information Systems (JSCMIS). 1: Requirements Definition and Design Specifications for Versions 2.1 and 2.1.1. 2: Documented Test Scenario Environments. 3: Security Design and Specifications

    1986-01-01

    The Johnson Space Center Management Information System (JSCMIS) is an interface to computer data bases at NASA Johnson which allows an authorized user to browse and retrieve information from a variety of sources with minimum effort. This issue gives requirements definition and design specifications for versions 2.1 and 2.1.1, along with documented test scenario environments, and security object design and specifications.

  13. 76 FR 70336 - Airworthiness Directives; Rolls-Royce plc RB211-524G2-19; -524G2-T-19; -524G3-19; -524G3-T-19...

    2011-11-14

    ... April 11, 2000 (65 FR 19477-78). Authority for This Rulemaking Title 49 of the United States Code... Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic impact, positive or... plc RB211-524G2-19; -524G2- T-19; -524G3-19; -524G3-T-19; 524H2-19; -524H2-T-19; -524H-36; and -...

  14. Clinical Value of Serum HMGB1 Levels in Early Detection of Recurrent Squamous Cell Carcinoma of Uterine Cervix: Comparison with Serum SCCA, CYFRA21-1, and CEA Levels

    Sheng, Xiugui; Du, Xuelian; Zhang, Xiaoling; Li, Dapeng; Lu, Chunhua; Li, Qinshui; Ma, Zhifang; Song, Quqing; Wang, Cong

    2009-01-01

    Aim To evaluate the clinical value of serum high mobility group box chromosomal protein 1 (HMGB1) levels in making the early diagnosis of recurrent cervical squamous cell carcinomas (CSCC) and compare it with the value of serum squamous cell carcinoma antigen (SCCA), cytokeratin fragment (CYFRA) 21-1, and carcinoembryonic antigen (CEA) levels. Methods Immunohistochemical staining of tissue from 64 patients with recurrent CSCCs, 72 patients with non-recurrent carcinoma,...

  15. The assessment of the prognostic value of tumor markers and cytokines as SCCAg, CYFRA 21.1, IL-6, VEGF and sTNF receptors in patients with squamous cell cervical cancer, particularly with early stage of the disease.

    Kotowicz, Beata; Fuksiewicz, Malgorzata; Jonska-Gmyrek, Joanna; Bidzinski, Mariusz; Kowalska, Maria

    2016-01-01

    The aim of this study is to determine the prognostic value of tumor markers, as squamous cell carcinoma antigen (SCCAg) and cytokeratin-19 fragment (CYFRA 21.1) and interleukin 6 (IL-6), vascular endothelial growth factor (VEGF), soluble tumor necrosis factor receptor I (sTNF RI), and sTNF RII in patients with squamous cell carcinoma of the cervix. The subjects of analysis were 138 patients with stage I-IVA according to the International Federation of Gynecology and Obstetrics (FIGO) classification. The collected research material comes from one oncology center. During the 10 years of follow-up, 56 relapses and 53 deaths were observed, and recurrent disease in early stage was confirmed in 45 % of patients. The pretreatment serum levels of SCCAg and CYFRA 21.1, and cytokines IL-6, VEGF, sTNF RI, and sTNF RII were determined in all patients. The probability of disease-free survival (DFS) and overall survival (OS) was evaluated using the log-rank test and the Cox regression model. Based on the ROC curve analysis for patients with recurrence, the largest area under the curve was demonstrated for SCCAg and IL-6 and for patients who died, for SCCAg and VEGF. Cox analysis demonstrated that independent prognostic factor for DFS was only SCCAg and for OS cytokine IL-6 and SCCAg, but in patients with early stage the prognostic value for DFS was VEGF, whereas IL-6 and CYFRA 21.1 for OS. Serum level of VEGF, CYFRA 21.1 and IL-6 before treatment in patients with early stage cervical cancer appears to be an important prognostic factor. PMID:26289850

  16. Two cases of partial trisomy 8p and partial monosomy 21q in a family with a reciprocal translocation (8;21)(p21.1;q22.3).

    Plomp, A.S.; Engelen, J.J.; Albrechts, J C; de Die-Smulders, C E; Hamers, A J

    1998-01-01

    We report on two mentally retarded adults with an unbalanced karyotype resulting from a familial balanced translocation between chromosomes 8 and 21, t(8;21)(p21.1;q22.3). This translocation has not been reported before. Both patients had partial trisomy 8p and partial monosomy 21q. Fluorescence in situ hybridisation (FISH) was used to determine the chromosomal breakpoints more precisely. The first patient showed mild mental retardation and facial dysmorphism, slightly resembling the earlier ...

  17. Radiotoxicity of systemically administered [211At]astatide in B6C3F1 and BALB/C (NU/NU) mice: A long-term survival study with histologic analysis

    Purpose: The present study undertook to establish the dose (LD) of systemically administered (via tail vein) sodium [211At]astatide that would kill 10% (LD10) of exposed animals in two mouse models and to evaluate the resulting histologic lesions. Methods and Materials: Three dose escalation experiments were carried out using groups of 10 3- to 4-week-old, 20 ± 2 g B6C3F1 mice, and one dose escalation experiment was carried out with groups of 10 4- to 6-week-old, 22 ± 2 g BALB/c (nu/nu) mice. All animals were weighed daily and checked twice daily for general health; autopsies were performed within 12 h of death. Results: The LD10 (95% confidence interval) level of free [211At]astatide at 360 days was 15.1 μCi (5.2-19.1 μCi) in B6C3F1 mice and was associated with a 37.8% weight difference from saline controls (p 10 at 360 days was 7.7 μCi (0-14.2 μCi), while a dose of 10 μCi (0.42 μCi g-1) was associated with a 9.44% weight difference vs. saline controls (p 211At]astatide activity levels were associated with severe bone marrow depression, testicular atrophy, focal alopecia, and nuclear atypia of the epidermoid mucosa of the fore-stomach in the B6C3F1 mice; at activity levels approximating LD10 at 360 days, mild changes in the heart, liver, stomach, and spleen were observed. For BALB/c (nu/nu) mice, administration of 10 μCi was associated at autopsy with mild histologic lesions in the heart, stomach, liver, and spleen. Conclusions: These studies provide a basis for the design of further investigations of [211At]-labeled compounds as therapeutic agents.

  18. Structural, elastic, and electronic properties of new 211 MAX phase Nb{sub 2}GeC from first-principles calculations

    Shein, I.R. [Institute of Solid State Chemistry, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620990 (Russian Federation); Ivanovskii, A.L., E-mail: ivanovskii@ihim.uran.ru [Institute of Solid State Chemistry, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620990 (Russian Federation)

    2013-02-01

    Very recently (2012, Phys. Rev Lett., 109, 035502) a new hexagonal (s.g. P63/mmc, Music-Sharp-Sign 194) ternary phase Nb{sub 2}GeC, which belongs to so-called 211-like MAX phases, was discovered. In order to get a systematic insight into the structural, elastic, and electronic properties of Nb{sub 2}GeC, we used two complementary DFT-based first-principles approaches (as implemented in the VASP and Wien2k packages) to calculate the optimized structural parameters, band structure, densities of state, Fermi surface, and a set of elastic parameters: elastic constants (C{sub ij}), bulk modulus (B), compressibility ({beta}), shear modulus (G), Young's modulus (Y), and elastic anisotropy indexes, which were discussed in comparison with available data. Besides, the inter-atomic bonding picture for Nb{sub 2}GeC was discussed using electron density maps and Bader's charge analysis.

  19. Ehlers-Danlos Syndrome, Hypermobility Type, Is Linked to Chromosome 8p22-8p21.1 in an Extended Belgian Family

    Delfien Syx

    2015-01-01

    Full Text Available Joint hypermobility is a common, mostly benign, finding in the general population. In a subset of individuals, however, it causes a range of clinical problems, mainly affecting the musculoskeletal system. Joint hypermobility often appears as a familial trait and is shared by several heritable connective tissue disorders, including the hypermobility subtype of the Ehlers-Danlos syndrome (EDS-HT or benign joint hypermobility syndrome (BJHS. These hereditary conditions provide unique models for the study of the genetic basis of joint hypermobility. Nevertheless, these studies are largely hampered by the great variability in clinical presentation and the often vague mode of inheritance in many families. Here, we performed a genome-wide linkage scan in a unique three-generation family with an autosomal dominant EDS-HT phenotype and identified a linkage interval on chromosome 8p22-8p21.1, with a maximum two-point LOD score of 4.73. Subsequent whole exome sequencing revealed the presence of a unique missense variant in the LZTS1 gene, located within the candidate region. Subsequent analysis of 230 EDS-HT/BJHS patients resulted in the identification of three additional rare variants. This is the first reported genome-wide linkage analysis in an EDS-HT family, thereby providing an opportunity to identify a new disease gene for this condition.

  20. The continuum limit of the $D$ meson, $D_s$ meson and charmonium spectrum from $N_f=2+1+1$ twisted mass lattice QCD

    Cichy, Krzysztof; Wagner, Marc

    2016-01-01

    We compute masses of $D$ meson, $D_s$ meson and charmonium states using $N_f=2+1+1$ Wilson twisted mass lattice QCD. All results are extrapolated to physical light quark masses, physical strange and charm quark masses and to the continuum. Our analysis includes states with spin $J = 0,1,2$, parity $\\mathcal{P} = -,+$ and in case of charmonium also charge conjugation $\\mathcal{C} = -,+$. Computations are based on a large set of quark-antiquark meson creation operators. We investigate and quantify all sources of systematic errors, including fitting range uncertainties, finite volume effects, isospin breaking effects and the choice of the fitting ansatz for the combined chiral and continuum extrapolation such that the resulting meson masses can be compared directly and in a meaningful way to experimental results. Within combined statistical and systematic errors, which are between below two per mille and three percent, our results agree with available experimental results for most of the states. In the few cases...

  1. The selenium-75-homocholic acid taurine test reevaluated: combined measurement of fecal selenium-75 activity and 3 alpha-hydroxy bile acids in 211 patients

    The recommended reference values for the selenium-75-homocholic acid taurine (75SeHCAT) test, used in the analysis of chronic diarrhea, were evaluated in 211 patients by comparing simultaneous measurements of 3 alpha-hydroxy bile acids and 75Se activity in daily collected stools. An initial evaluation in 11 patients showed that the fecal collection method, which allows inspection and additional analysis of stools, was equivalent to the abdominal retention method. Selenium-75-HCAT whole-body retention half-life (WBR50) was greater than 2.8 days in less than 10% of the patients with bile acid malabsorption and less than 1.7 days in less than 10% of the normals. We recommend that a 75SeHCAT WBR50 less than 1.7 days is abnormal, a WBR50 greater than 2.8 days is normal, and a WBR50 in the range 1.7-2.8 days is equivocal, which was the case in 48% (94/195) of the patients in this study

  2. The inhomogeneous ISM toward PKS1830-211 SW - A detailed view on molecular gas at a look-back time of 7.5 Gyr

    Schulz, A; Menten, K M; Muller, S; Muders, D; Bagdonaite, J; Ubachs, W

    2014-01-01

    Based on measurements with the Effelsberg 100-m telescope, a multi-line study of molecular species is presented toward the south-western source of the gravitational lens system PKS 1830-211, which is by far the best known target to study molecular gas in absorption at intermediate redshift. Determining line parameters and optical depths and performing Large Velocity Gradient radiative transfer calculations, the aims of this study are (1) to evaluate physical parameters of the absorbing foreground gas at z~0.89, in particular its homogeneity, and (2) to monitor the spectroscopic time variability caused by fluctuations of the z~2.5 background continuum source. We find, that the gas is quite inhomogeneous with n(H2)~2 x 10^3 cm^-3 for most molecular species but with higher values for H2CO and lower ones for SO. Measuring the CS J=1-0 transition during a time interval of more than a decade, from 2001 to 2012, the peak absorption depth of the line remains approximately constant, while the line shape undergoes nota...

  3. Ehlers-Danlos Syndrome, Hypermobility Type, Is Linked to Chromosome 8p22-8p21.1 in an Extended Belgian Family.

    Syx, Delfien; Symoens, Sofie; Steyaert, Wouter; De Paepe, Anne; Coucke, Paul J; Malfait, Fransiska

    2015-01-01

    Joint hypermobility is a common, mostly benign, finding in the general population. In a subset of individuals, however, it causes a range of clinical problems, mainly affecting the musculoskeletal system. Joint hypermobility often appears as a familial trait and is shared by several heritable connective tissue disorders, including the hypermobility subtype of the Ehlers-Danlos syndrome (EDS-HT) or benign joint hypermobility syndrome (BJHS). These hereditary conditions provide unique models for the study of the genetic basis of joint hypermobility. Nevertheless, these studies are largely hampered by the great variability in clinical presentation and the often vague mode of inheritance in many families. Here, we performed a genome-wide linkage scan in a unique three-generation family with an autosomal dominant EDS-HT phenotype and identified a linkage interval on chromosome 8p22-8p21.1, with a maximum two-point LOD score of 4.73. Subsequent whole exome sequencing revealed the presence of a unique missense variant in the LZTS1 gene, located within the candidate region. Subsequent analysis of 230 EDS-HT/BJHS patients resulted in the identification of three additional rare variants. This is the first reported genome-wide linkage analysis in an EDS-HT family, thereby providing an opportunity to identify a new disease gene for this condition. PMID:26504261

  4. ‘The woman was deceived and became a sinner’ – a literary-theological investigation of 1 Timothy 2:11–15

    Abiola I. Mbamalu

    2014-02-01

    Full Text Available In 1 Timothy 2:11–15 women are forbidden to teach and have authority over men in the church. The ground for this instruction is the creation account in Genesis 2 that asserts the priority of Adam over Eve in the order of creation. The second reason for the instruction is the deception of Eve according to the account of the Fall in Genesis 3. This pericope has elicited arguments between advocates of egalitarianism and complementarianism revolving over the issues of grammar, the context of the Ephesian church with regard to false teachings and the comparison of this text with the other writings of Paul, for those that subscribe to the authorship of Paul. The contention of this article is that verse 15 provides a major clue as to how this text should be understood. In addition, the author’s rhetoric in this text is interrogated with regard to the text’s own internal literary and theological logic. In this regard, the author is found to be inconsistent in his outlook, for the grace that was poured out abundantly on him: a blasphemer, a persecutor and a violent man and on account of his ignorance andunbelief (1 Tm 1:12–16 is apparently, being denied women on account of Eve’s deception.

  5. Characterization of a mutant Escherichia coli heat-labile toxin, LT(R192G/L211A), as a safe and effective oral adjuvant.

    Norton, Elizabeth B; Lawson, Louise B; Freytag, Lucy C; Clements, John D

    2011-04-01

    Despite the fact that the adjuvant properties of the heat-labile enterotoxins of Escherichia coli (LT) and Vibrio cholerae (CT) have been known for more than 20 years, there are no available oral vaccines containing these molecules as adjuvants, primarily because they are both very potent enterotoxins. A number of attempts with various degrees of success have been made to reduce or eliminate the enterotoxicity of LT and CT so they can safely be used as oral adjuvants or immunogens. In this report we characterize the structural, enzymatic, enterotoxic, and adjuvant properties of a novel mutant of LT, designated LT(R192G/L211A), or dmLT. dmLT was not sensitive to trypsin activation, had reduced enzymatic activity for induction of cyclic AMP in Caco-2 cells, and exhibited no enterotoxicity in the patent mouse assay. Importantly, dmLT retained the ability to function as an oral adjuvant for a coadministered antigen (tetanus toxoid) and to elicit anti-LT antibodies. In vitro and in vivo data suggest that the reduced enterotoxicity of this molecule compared to native LT or the single mutant, LT(R192G), is a consequence of increased sensitivity to proteolysis and rapid intracellular degradation in mammalian cells. In conclusion, dmLT is a safe and powerful detoxified enterotoxin with the potential to function as a mucosal adjuvant for coadministered antigens and to elicit anti-LT antibodies without undesirable side effects. PMID:21288994

  6. Effect of F doping on physical properties of (211) oriented SnO2 thin films prepared by jet nebulizer spray pyrolysis technique

    Thirumoorthi, M.; Prakash, J. Thomas Joseph

    2016-01-01

    Transparent conducting fluorine doped tin oxide (FTO) thin films have been prepared jet nebulizer spray pyrolysis technique at 500 °C for different doping concentrations. The X-ray diffraction spectra confirm the polycrystalline nature of SnO2: F with tetragonal structure. All the films show a preferred growth orientation along (211) diffraction plane. Scanning electron microscope images show that the films have a uniform surface morphology with well defined pyramid like grains. The AFM results of the films indicate that the surface roughness is increased with F doping. The optical transmittance of FTO films is improved from 75 to 92% in the visible region of the solar spectrum and the optical absorption of the films is very low. The blue shift of optical band of the films is explained by Burstain-Mass effect. The observed blue shift of the UV emission band in the photoluminescence spectra confirms the incorporation of F into tin oxide crystal lattice. The presence of functional groups and chemical bonding were confirmed by FTIR. Hall Effect measurements show that the prepared films having n-type conductivity with low resistivity (2.3 × 10-4 Ω-cm) and high carrier concentrations (6.9 × 1020 cm-3).

  7. 血清 CEA、CYFAR21-1、SCC、CA125水平对晚期非小细胞肺癌放疗疗效的评估价值%Assessment Value of Serum CEA,CYFAR21-1,SCC,CA125 Levels in Efficacy of Radiotherapy for Advanced Non-small Cell Lung Cancer

    阿合力·那斯肉拉; 巴尔夏古丽·扎比胡拉; 穆朝东

    2014-01-01

    目的:探讨血清肿瘤标志物水平对晚期非小细胞肺癌患者放疗疗效的评估价值。方法将晚期非小细胞肺癌患者共176例,分为观察组(近期放疗有效)和对照组(近期放疗无效),采用电化学发光法检测放疗前、后血清肿瘤CEA、CYFAR21-1、SCC、CA125水平。结果176例患者放疗有效率为58.0%,观察组放疗前血清CEA、CYFAR21-1、SCC、CA125水平分别为(33.65±5.41)ng/ml、(19.44±3.14)ng/ml、(16.87±2.74)ng/ml、(46.81±5.49)U/ml,放疗后各项标志物水平分别为(25.13±4.65)ng/ml、(12.35±4.18)ng/ml、(11.77±3.04)ng/ml、(39.67±4.63)U/ml,均明显低于放疗前,差异均有统计学意义(P<0.05);对照组放疗前血清肿瘤标志物CEA、CYFAR21-1、SCC、CA125水平分别为(46.87±5.93)ng/ml、(28.63±10.82)ng/ml、(26.46±8.68)ng/ml、(68.16±7.38)U/ml,放疗后各项标志物水平分别为(52.17±5.49)ng/ml、(46.72±11.75)ng/ml、(38.74±63.48)ng/ml、(87.34±8.16)U/ml,均明显高于放疗前,差异均有统计学意义(P<0.05);观察组放疗前各项标志物水平均低于对照组,差异显著(P<0.05);对照组放疗后标志物水平降低患者的近期疗效明显好于放疗后血清肿瘤标志物水平升高者,差异有统计学意义(χ2=76.45,P<0.05)。结论肿瘤血清肿瘤标志物CEA、CYFAR21-1、SCC、CA125的水平对晚期非小细胞肺癌患者放疗疗效具有评估价值。%Objective To explore the assessment value of serum level of tumor markers in efficacy of radiotherapy for advanced non-small cell lung cancer .Methods 176 cases of advanced non-small cell lung cancer were divided into 2 groups:the observation group ( recent radiotherapy effective ) and the control group ( recent radiotherapy invalid ) , tumor

  8. Prepuberal stimulation of 5-HT7-R by LP-211 in a rat model of hyper-activity and attention-deficit: permanent effects on attention, brain amino acids and synaptic markers in the fronto-striatal interface.

    Lucia A Ruocco

    Full Text Available The cross-talk at the prefronto-striatal interface involves excitatory amino acids, different receptors, transducers and modulators. We investigated long-term effects of a prepuberal, subchronic 5-HT7-R agonist (LP-211 on adult behaviour, amino acids and synaptic markers in a model for Attention-Deficit/Hyperactivity Disorder (ADHD. Naples High Excitability rats (NHE and their Random Bred controls (NRB were daily treated with LP-211 in the 5th and 6th postnatal week. One month after treatment, these rats were tested for indices of activity, non selective (NSA, selective spatial attention (SSA and emotionality. The quantity of L-Glutamate (L-Glu, L-Aspartate (L-Asp and L-Leucine (L-Leu, dopamine transporter (DAT, NMDAR1 subunit and CAMKIIα, were assessed in prefrontal cortex (PFC, dorsal (DS and ventral striatum (VS, for their role in synaptic transmission, neural plasticity and information processing. Prepuberal LP-211 (at lower dose reduced horizontal activity and (at higher dose increased SSA, only for NHE but not in NRB rats. Prepuberal LP-211 increased, in NHE rats, L-Glu in the PFC and L-Asp in the VS (at 0.250 mg/kg dose, whereas (at 0.125 mg/kg dose it decreased L-Glu and L-Asp in the DS. The L-Glu was decreased, at 0.125 mg/kg, only in the VS of NRB rats. The DAT levels were decreased with the 0.125 mg/kg dose (in the PFC, and increased with the 0.250 mg/kg dose (in the VS, significantly for NHE rats. The basal NMDAR1 level was higher in the PFC of NHE than NRB rats; LP-211 treatment (at 0.125 mg/kg dose decreased NMDAR1 in the VS of NRB rats. This study represents a starting point about the impact of developmental 5-HT7-R activation on neuro-physiology of attentive processes, executive functions and their neural substrates.

  9. 肿瘤标志物NSE TPS CYFRA 21-1联合检测肺癌%Combined Assays of Neurone Specific Enolase,Tissue Polypeptide Specific Antigen and Cytokeratin 19 Fragment Marker in Lung Cancer

    李文新; 成绥生; 刘阿秋; 张翠英; 贾向东; 李智军

    2005-01-01

    目的:评价神经元特异性烯醇化酶(NSE)、组织特异性抗原(TPS)和细胞角蛋白19片段(CY-FRA 21-1)在各种病理类型肺癌中诊断的应用价值,通过联检观察它们在肺癌诊断中的敏感性和准确性.方法:收集血清标本127例,其中肺鳞癌22例,腺癌19例,小细胞肺癌16例,不能分型肺癌组13例;肺部良性疾病组27例和正常对照组30例.采用酶联免疫吸附试验进行检测.结果:TPS、NSE和CYFRA 21-1在肺癌各病理类型组的血清水平与正常对照组有差异(P<0.05),NSE和TPS在肺癌各病理类型组的血清水平高于良性病变组(P<0.05),CYFRA 21-1在肺癌各病理类型组的血清含量与肺癌良性疾病组无差异(P>0.05).NSE在小细胞肺癌组的血清水平与肺部良性病变组和正常对照组有显著性差异(P<0.01),NSE在小细胞肺癌组的敏感性为75%,与肺腺癌组比较有差异(P<0.05),特异性为96.5%.TPS在肺癌组的灵敏度最高,为85.7%,在肺部良性病变组的灵敏度为29.6%,TPS在肺癌各病理类型组的灵敏度无差异(P>0.05),其特异性为78.9%.CYFRA 21-1在肺癌的灵敏度分别为27.1%,CYFRA 21-1在肺鳞癌中灵敏度最高,36.4%.TPS、NSE和CYFRA 21-1三项联检,可明显提高肺癌诊断的灵敏度,但同时特异性有所下降.结论:NSE是对小细胞肺癌具有高特异性和高敏感性的肿瘤标志物,在小细胞肺癌诊断上具有重要的参考意义.TPS在肺癌诊断上灵敏度较高,但特异性较差,不宜单独用于肺癌诊断.CYFRA 21-1在肺癌诊断上灵敏度较低,但特异性强,在肺癌诊断上有一定的参考价值,上述三项标志物联检可提高肺癌的检出率,有一定的临床价值.

  10. Fine-Mapping of 18q21.1 Locus Identifies Single Nucleotide Polymorphisms Associated with Nonsyndromic Cleft Lip with or without Cleft Palate

    Mitra, Amit K.; Stessman, Holly A. F.; Schaefer, Robert J.; Wang, Wen; Myers, Chad L.; Van Ness, Brian G.; Beiraghi, Soraya

    2016-01-01

    Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common congenital birth defects. NSCL/P is a complex multifactorial disease caused by interactions between multiple environmental and genetic factors. However, the causal single nucleotide polymorphism (SNP) signature profile underlying the risk of familial NSCL/P still remains unknown. We previously reported a 5.7-Mb genomic region on chromosome 18q21.1 locus that potentially contributes to autosomal dominant, low-penetrance inheritance of NSCL/P. In the current study, we performed exome sequencing on 12 familial genomes (six affected individuals, two obligate carriers, and four seemingly unaffected individuals) of a six-generation family to identify candidate SNPs associated with NSCL/P risk. Subsequently, targeted bidirectional DNA re-sequencing of polymerase chain reaction (PCR)-amplified high-risk regions of MYO5B gene and sequenom iPLEX genotpying of 29 candidate SNPs were performed on a larger set of 33 members of this NSCL/P family (10 affected + 4 obligate carriers + 19 unaffected relatives) to find SNPs significantly associated with NSCL/P trait. SNP vs. NSCL/P association analysis showed the MYO5B SNP rs183559995 GA genotype had an odds ratio of 18.09 (95% Confidence Interval = 1.86–176.34; gender-adjusted P = 0.0019) compared to the reference GG genotype. Additionally, the following SNPs were also found significantly associated with NSCL/P risk: rs1450425 (LOXHD1), rs6507992 (SKA1), rs78950893 (SMAD7), rs8097060, rs17713847 (SCARNA17), rs6507872 (CTIF), rs8091995 (CTIF), and rs17715416 (MYO5B). We could thus identify mutations in several genes as key candidate SNPs associated with the risk of NSCL/P in this large multi-generation family. PMID:27242896

  11. Fine-Mapping of 18q21.1 Locus Identifies Single Nucleotide Polymorphisms Associated with Nonsyndromic Cleft Lip with or without Cleft Palate.

    Mitra, Amit K; Stessman, Holly A F; Schaefer, Robert J; Wang, Wen; Myers, Chad L; Van Ness, Brian G; Beiraghi, Soraya

    2016-01-01

    Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common congenital birth defects. NSCL/P is a complex multifactorial disease caused by interactions between multiple environmental and genetic factors. However, the causal single nucleotide polymorphism (SNP) signature profile underlying the risk of familial NSCL/P still remains unknown. We previously reported a 5.7-Mb genomic region on chromosome 18q21.1 locus that potentially contributes to autosomal dominant, low-penetrance inheritance of NSCL/P. In the current study, we performed exome sequencing on 12 familial genomes (six affected individuals, two obligate carriers, and four seemingly unaffected individuals) of a six-generation family to identify candidate SNPs associated with NSCL/P risk. Subsequently, targeted bidirectional DNA re-sequencing of polymerase chain reaction (PCR)-amplified high-risk regions of MYO5B gene and sequenom iPLEX genotpying of 29 candidate SNPs were performed on a larger set of 33 members of this NSCL/P family (10 affected + 4 obligate carriers + 19 unaffected relatives) to find SNPs significantly associated with NSCL/P trait. SNP vs. NSCL/P association analysis showed the MYO5B SNP rs183559995 GA genotype had an odds ratio of 18.09 (95% Confidence Interval = 1.86-176.34; gender-adjusted P = 0.0019) compared to the reference GG genotype. Additionally, the following SNPs were also found significantly associated with NSCL/P risk: rs1450425 (LOXHD1), rs6507992 (SKA1), rs78950893 (SMAD7), rs8097060, rs17713847 (SCARNA17), rs6507872 (CTIF), rs8091995 (CTIF), and rs17715416 (MYO5B). We could thus identify mutations in several genes as key candidate SNPs associated with the risk of NSCL/P in this large multi-generation family. PMID:27242896

  12. Reflection asymmetry in odd-A and odd-odd actinium nuclei

    Theoretical calculations and measurements indicate that octupole correlations are at a maximum in the ground states of the odd-proton nuclei Ac and Pa. It has been expected that odd-odd nuclei should have even larger amount of octupole-octupole correlations. We have recently made measurements on the structure of 224Ac. Although spin and parity assignments could not be made, two bands starting at 354.1 and 360.0 keV have properties characteristic of reflection asymmetric shape. These two bands have very similar rotational constants and also similar alpha decay rates, which suggest similarity between the wavefunctions of these bands. These signatures provide evidence for octupole correlations in these nuclides

  13. Bestimmung der Ionisationsenergie von Actinium und Ultraspurenanalyse von Plutonium mit resonanter Ionisationsmassenspektrometrie (RIMS)

    Waldek, Achim Marcus

    2001-01-01

    ZusammenfassungDie Resonanzionisationsmassenspektrometrie (RIMS) verbindet hohe Elementselektivität mit guter Nachweiseffizienz. Aufgrund dieser Eigenschaften ist die Methode für Ultraspurenanalyse und Untersuchungen an seltenen oder schwer handhabbaren Elementen gut geeignet. Für RIMS werden neutrale Atome mit monochromatischem Laserlicht ein- oder mehrfach resonant auf energetisch hoch liegende Niveaus angeregt und anschließend durch einen weiteren Laserstrahl oder durch ein elektrisches Fe...

  14. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228

    The activities of 228Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide 228Ac. The radium was pre-concentrated on MnO2 and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter 228Ra(228Ac), the daughter nuclide 228Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by 228Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9±0.1% was measured for 228Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317±0.013 cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1 g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of 228Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for 228Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure 228Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used

  15. Linear free energy relationship applied to trivalent cations with lanthanum and actinium oxide and hydroxide structure

    Linear free energy relationships for trivalent cations with crystalline M2O3 and, M(OH)3 phases of lanthanides and actinides were developed from known thermodynamic properties of the aqueous trivalent cations, modifying the Sverjensky and Molling equation. The linear free energy relationship for trivalent cations is as ΔGf,MvX0=aMvXΔGn,M3+0+bMvX+βMvXrM3+, where the coefficients aMvX, bMvX, and βMvX characterize a particular structural family of MvX, rM3+ is the ionic radius of M3+ cation, ΔGf,MvX0 is the standard Gibbs free energy of formation of MvX and ΔGn,M3+0 is the standard non-solvation free energy of the cation. The coefficients for the oxide family are: aMvX=0.2705, bMvX=-1984.75 (kJ/mol), and βMvX=197.24 (kJ/molnm). The coefficients for the hydroxide family are: aMvX=0.1587, bMvX=-1474.09 (kJ/mol), and βMvX=791.70 (kJ/molnm).

  16. Actinium: A RESTful Runtime Container for Scriptable Internet of Things Applications

    Kovatsch, Matthias; Lanter, Martin; Duquennoy, Simon

    2012-01-01

    Programming Internet of Things (IoT) applications is challenging because developers have to be knowledgeable in various technical domains, from low-power networking, over embedded operating systems, to distributed algorithms. Hence, it will be challenging to find enough experts to provide software for the vast number of expected devices, which must also be scalable and particularly safe due to the connection to the physical world. To remedy this situation, we propose an architecture that pr...

  17. Synthesis of chelating agents for actinium 225 complexation and its application in radioimmunotherapy

    Immunotherapy with radiolabeled antibodies should allow fairly specific targeting of certain cancers. However, iodine 131 may not be the best isotope for tumor therapy because of its limited specific activity, low beta-energy, relatively long half life and strong gamma emission. Another approach to improve therapeutic efficacy is the use of replacement isotopes with better physical properties. Chelator that can hold radio-metals with high stability under physiological conditions are essential to avoid excessive damage to non-target cells; Moreover, the development of new bifunctional chelating agents is essential for this purpose. Accordingly, our efforts have been directed, for several years, to the synthesis of original chelating agents likely to form stable complexes in vivo with the numerous potential candidates for such applications. Therefore, we have developed a new simple and efficient synthesis pathway of 2-(4-iso-thio-cyanate-benzyl)-1,4,7,10,13,16- hexa-aza-cyclo-hexadecane- 1,4,7,10,13,16-hexa-acetic acid, though functionalized on the cycle by a termination allowed coupling to an antibody or any other biological substance such as a hapten. (author)

  18. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    A technique of selenium purification from 232Th, 238U, 226,228Ra, 227Ac and 40K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  19. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    Rakhimov, A.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz); Warot, G. [CEA-CNRS, Modane (France). Laboratoire Souterrain de Modane (LSM); Karaivanov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Institute for Nuclear Research and Nuclear Energy (INRNE), Sofia (Bulgaria); Kochetov, O.I.; Lebedev, N.A.; Filosofov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Mukhamedshina, N.M.; Sadikov, I.I. [Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz)

    2013-07-01

    A technique of selenium purification from {sup 232}Th, {sup 238}U, {sup 226,228}Ra, {sup 227}Ac and {sup 40}K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  20. Performance of biomarkers SMRP, CA125, and CYFRA 21-1 as potential tumor markers for malignant mesothelioma and lung cancer in a cohort of workers formerly exposed to asbestos

    Gube, M. [RWTH Aachen University, Institute for Occupational and Social Medicine, Medical Faculty, Aachen (Germany); Westfaelische Technische Hochschule, Institut fuer Arbeitsmedizin und Sozialmedizin am Universitaetsklinikum Aachen, Rheinisch, Aachen (Germany); Taeger, D.; Weber, D.G.; Pesch, B.; Johnen, G.; Gross, I.M.; Wiethege, T.; Weber, A.; Bruening, T. [Institute of the Ruhr-Universitaet Bochum (IPA), Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Bochum (Germany); Brand, P.; Mueller-Lux, A.; Kraus, T. [RWTH Aachen University, Institute for Occupational and Social Medicine, Medical Faculty, Aachen (Germany); Raithel, H.J. [University of Erlangen-Nuremberg, Institute for Occupational, Social and Environmental Medicine, Erlangen-Nuremberg (Germany)

    2011-03-15

    The aim of the study is to examine the cancer-predictive values of SMRP (soluble mesothelin-related peptides), CA125, and CYFRA21-1 as potential tumor markers for lung cancer and malignant mesothelioma in a cohort of workers formerly exposed to asbestos. A voluntary surveillance program has been established for German workers with former asbestos exposure. A subgroup of 626 subjects with a mean age of 63 years (range 53-70 years) at baseline was enrolled in an extended health examination program with high-resolution computer tomography (HRCT) of the chest and blood drawing between 1993 and 1997. Serum concentrations of SMRP, CA125, and CYFRA21-1 were measured in archived serum samples in 2005 and 2006. A mortality follow-up was conducted through 2007. So far, 12 cases with lung cancer and 20 cases with malignant mesothelioma have been observed in this cohort. The average time between sample collection and diagnosis was 4.7 years. Analyzed biomarkers showed low sensitivities (5-25%) and positive predictive values (4-30%) for both cancer sites. Marker combinations resulted in sensitivities between 5 and 50% and positive predictive values ranging from 3 to 14%. Even in those cases, where biomarker concentrations were available within 36 months before diagnosis, no trend for increasing biomarker levels was observed. The analyzed tumor markers were characterized by high specificities, but low sensitivities. SMRP, CA125, and CYFRA21-1 alone or in combination were less suitable to serve as predictors for the diagnosis of lung cancer or malignant mesothelioma. However, a prospective study with annual sampling might reveal a better predictive value of these markers. (orig.)

  1. Performance of biomarkers SMRP, CA125, and CYFRA 21-1 as potential tumor markers for malignant mesothelioma and lung cancer in a cohort of workers formerly exposed to asbestos

    The aim of the study is to examine the cancer-predictive values of SMRP (soluble mesothelin-related peptides), CA125, and CYFRA21-1 as potential tumor markers for lung cancer and malignant mesothelioma in a cohort of workers formerly exposed to asbestos. A voluntary surveillance program has been established for German workers with former asbestos exposure. A subgroup of 626 subjects with a mean age of 63 years (range 53-70 years) at baseline was enrolled in an extended health examination program with high-resolution computer tomography (HRCT) of the chest and blood drawing between 1993 and 1997. Serum concentrations of SMRP, CA125, and CYFRA21-1 were measured in archived serum samples in 2005 and 2006. A mortality follow-up was conducted through 2007. So far, 12 cases with lung cancer and 20 cases with malignant mesothelioma have been observed in this cohort. The average time between sample collection and diagnosis was 4.7 years. Analyzed biomarkers showed low sensitivities (5-25%) and positive predictive values (4-30%) for both cancer sites. Marker combinations resulted in sensitivities between 5 and 50% and positive predictive values ranging from 3 to 14%. Even in those cases, where biomarker concentrations were available within 36 months before diagnosis, no trend for increasing biomarker levels was observed. The analyzed tumor markers were characterized by high specificities, but low sensitivities. SMRP, CA125, and CYFRA21-1 alone or in combination were less suitable to serve as predictors for the diagnosis of lung cancer or malignant mesothelioma. However, a prospective study with annual sampling might reveal a better predictive value of these markers. (orig.)

  2. Compliance. Regulatory policy P-211

    This regulatory policy describes the basic principles and directives for establishing and conducting the Canadian Nuclear Safety Commission (CNSC) Compliance Program. The program is aimed at securing compliance by regulated persons with regulatory requirements made under the Nuclear Safety and Control Act ('the Act'). The policy applies to persons who are regulated by the CNSC through the Act, regulations and licences, as well as by decisions and orders made under the Act. The policy applies to officers and employees of the CNSC, and its authorized representatives or agents, who are involved in developing and carrying out compliance activities. Compliance, in the context of this policy, means conformity by regulated persons with the legally binding requirements of the Act, and the CNSC regulations, licences, decisions, and orders made under the Act. Compliance activities are CNSC measures of promotion, verification and enforcement aimed at securing compliance by regulated person with the applicable legally binding requirements. (author)

  3. Crestridge Vegetation Map [ds211

    California Department of Resources — This layer represents vegetation communities in the Department of Fish and Game's Crestridge Ecological Reserve. The County of San Diego, the Conservation Biology...

  4. 头颈部鳞状细胞癌血清SCC、CYFRA21-1、NSE、CEA联合检测的临床意义%Clinical value of combined detection of tumor markers for nasopharyngeal carcinoma and squamous cell carcinoma in head and neck

    王继生; 孙艳

    2009-01-01

    Objective To study the clinical value of serum SCC,CYFRA21-1,NSE and CEA for patients with nasopharyngeal carcinoma (NPC) and squamous cell carcinoma of head and neck (NHSCC). Methods From Aug 2004 to Sep 2007, the serum levels of SCC, CYFRA21-1, NSE and CEA were detected in 79 NPC and 51 HNSCC before and after radiotherapy. The clinical related factors were analyzed. Results Before treatment, the positive rates of serum SCC, CYFRA21-1, NSE and CEA for patients with NPC were 10.53 %, 46.75 %, 17.5 % and 2.04 %, respectively. The sensitivity of combined detection was 78.95 %. The positive rates for patients with HNSCC were 22 %, 19.75 %, 11.11% and 0, respectively. The sensitivity of combined detection was 36.17 %. The level of SCC was related to staging in HNSCC group. CYFRA21-1 was related to the rote of treatment response in NPC group. Conclusion The sensitivity of combined detection of tumor markers were significantly increased. CYFRA21-1 associated with NPC and SCC with HNSCC were noted in this study.%目的 探讨血清鳞状细胞癌相关抗原(SCC)、细胞角蛋白19血清片段21-1(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)在鼻咽癌(NPC)和头其他颈部鳞癌(HNSCC)患者临床诊疗中的价值.方法 在2004年8月至2007年9月接受放疗的患者中,79例NPC和51例HNSCC治疗前后进行了血清SCC、CYFRA21-1、NSE和CEA水平的检测,对其结果与临床相关因素的关系进行分析.结果 治疗前NPC患者血清SCC、CYFRA21-1、NSE和CEA阳性率分别为10.53%、46.75%、17.50%和2.04%,联合检测阳性率是78.95%;HNSCC分别为22.00%、19.75%、11.11%、0,联合检测是36.17%,联合检测阳性率均明显增高(P<0.01).NPC治疗后血清CYFRA 21-1和NSE水平明显下降(P<0.0001),CYFRA 21-1与近期疗效相关(P=0.0339);HNSCC组中SCC与分期有相关趋势(P=0.0597).结论 联合检测的敏感性较单项检查高,可以提高HNSCC的阳性检出率,有较高的临床诊断价值.CYFRA 21-1

  5. Manndráp og meiriháttar líkamsmeiðingar - Mörk 211. gr. og 2. mgr. 218. gr. hgl. þegar bani hlýst af atlögu

    Sonja Hjördís Berndsen 1986

    2011-01-01

    Efni ritgerðar þessarar eru skilin milli ákvæðis 211. gr. um manndráp af ásetningi og ákvæðis 2. mgr. 218. gr. almennra hegningarlaga nr. 19/1940 um meiriháttar líkamsárás, þegar bani hlýst af atlögu. Verknaður sem leiðir til dauða er felldur undir 211. gr. hgl. nái ásetningur geranda bæði til frumverknaðar og þess dauðdaga sem fylgir verknaðinum. Verði afleiðingarnar sem í dauðdaganum felast eingöngu raktar til gáleysis geranda, er háttsemi felld undir 2. mgr. 218. gr. hgl. Við athugun á...

  6. 手机QR码在OPAC馆藏目录检索中的应用现状调查与思考——以“211工程”院校为例

    朱丽君; 亢琦; 代学冬

    2012-01-01

    对116所"211工程"高校图书馆的手机QR码在国内外著名图书馆自动化集成系统中的应用现状进行了调查,从馆藏书目QR(Quick Response)码在OPAC检索结果页面的集成与否、QR码识别信息是否全面、QR码的显示大小、QR码的显示分辨率、显示位置和使用说明链接六个方面对调查所得的数据进行分析,探究手机QR码在OPAC中的应用现状和存在的问题,以便启发手机QR码应用到更多图书馆的OPAC检索平台中。%The paper selects 116 libraries of Project 211 universities to investigate the application situation of mobile phone QR(Quick Response) code in some well-known library integrated management systems at home and abroad,including the OPAC search result page is integrated or not;information recognition is comprehensive or not;the size,resolution,location of the display are suitable to read or not;and the instruction for use is hyperlinked to or not.

  7. Dynamic Mechanical Analysis (DMA) to Help Characterize Vespel SP-211 Polyimide Material for Use as a 750 F Valve Seal on the Ares I Upper Stage J-2X Engine

    Wingard, Doug

    2013-01-01

    DuPont(tm) Vespel(R) SP-211 polyimide was selected as the top candidate seal material for use in the Oxidizer Turbine Bypass Valve (OTBV) on NASA's Ares I Upper Stage J-2X engine. In the OTBV, the seal material would get exposed to temperatures up to 750degF for approx 10 minutes at a time. Although the J-2X engine is not reusable, the valve material could be exposed to multiple temperature cycles up to 750degF during engine operation. The Constellation Program that included the Ares I rocket was eventually cancelled, but the J-2X engine was chosen for continued use for development of NASA's Space Launch System (SLS). The SLS is a heavy-lift launch vehicle that will have capability of taking astronauts and hardware to the Moon, Mars and asteroids. Dynamic mechanical analysis (DMA) was one of several test techniques used to characterize Vespel SP-211 to help prove its worthiness for use on the OTBV of the J-2X engine.

  8. Clinical application of the tumor marker CYFRA 21-1 in squamous cell carcinoma of the head and neck%CYFRA 21-1在头颈鳞状细胞癌患者中的临床应用

    邓燕飞; 陈平; 林永志; 乐家振; 余明强; 邬晓力; 高明华; 杨海斌; 庄佩耘; 洪拥军

    2002-01-01

    目的:探讨肿瘤标志物CYERA 21-1(CYFRA)在头颈鳞状细胞癌(简称鳞癌)中的临床应用价值.方法:采用电化学发光免疫分析技术检测了30例健康人、42例头颈部良性肿瘤和90例头颈鳞癌患者的CYFRA血清浓度.结果:①头颈鳞癌患者CYFRA血清水平明显高于头颈部良性肿瘤患者和健康人(P<0.01);②CYFRA的诊断敏感性为62.2%,特异性为100%;③CYFRA血清水平与头颈鳞癌患者的肿瘤分期相关(P<0.01),与患者的年龄、性别、烟酒习性及肿瘤的分化程度无关(P>0.05);④头颈鳞癌治疗后CYFRA血清水平明显下降(P<0.01).结论:CYFRA是一个十分有用的血清学肿瘤标志物,在头颈鳞癌的诊断、病情监测和疗效观察等方面具有较好的临床应用价值.

  9. Embracing a vision of the New Jerusalem (Rv 21:1−22:5 to impact on life and society

    Martin H. Pohlmann

    2015-03-01

    Full Text Available Apocalyptic biblical literature has played a significant role in motivating and mobilising Christians. As part of this genre, the Apocalypse of John has played this mobilising role within the church throughout its history. Jerusalem is often incorporated into this genre to conjure up different emotions and images to impact many different people. For example, the Jew annually recites the words to fellow Jews at every Passover meal: ‘Next year in Jerusalem’. Most Christians know the hymn ‘The holy city’, originally penned by Frederic Weatherly in 1892. It lifts many a spirit as it conjures up the idea of a beautiful, perfect, heavenly city of God. However, there is more to this apocalyptic vision, which will be explored in this article. The city upholds the hope of decent godly living today. Whilst Jerusalem is a city with an extremely chequered history, it remains to be the launching pad of a dream that believers can embrace in order to impact society for the better. The vision in Revelation 21–22 is the launch of the ‘idea’ of God’s intention for society today, and the ‘implementation impetus’ is the primary role of the church. In the greater scheme of things, the world community is the target group for a better society for everyone.Aanneming van ’n visioen van die Nuwe Jerusalem (Op 21:1–22:5 ten einde ’n invloed op lewe en die samelewing uit te oefen. Apokaliptiese Bybelliteratuur het ’n beduidende rol in die motivering en aansporing van Christengemeenskappe gespeel. Die Openbaring van Johannes het hierdie motiveringsrol deurgaans in die geskiedenis van die kerkas deel van dié genre vertolk. Jerusalem is dikwels hierby ingesluit om ’n verskeidenheid van emosies en beelde op te roep ten einde ’n impak op ’n verskeidenheid mense te maak. Die Jood, byvoorbeeld, haal jaarliks die volgende woorde teenoor mede-Jode tydens die Paasmaaltyd aan: ‘Volgende jaar in Jerusalem’. Die meeste

  10. AB161. High resolution melting analysis of buccal DNA revealed a significant association between UGT1A1 c.211G>A and neonatal hyperbilirubinemia development in Malay population

    Cheung, Tian Pei; Van Rostenberghe, Hans; Ismail, Rosliza; Nawawi, Noor Namirah; Abdullah, Nurul Amierah; Ramli, Noraida; Ibrahim, Nor Rosidah; Hj Abd Majid, Noorizan; Mohd Yusoff, Narazah; Nishio, Hisahide; Yusoff, Surini

    2015-01-01

    Background Severe neonatal hyperbilirubinemia or neonatal jaundice (NNJ) characterised by an elevated total serum bilirubin (TSB) level may result in kernicterus or even death. Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) is the key enzyme which conjugates bilirubin with glucuronic acid for the subsequent bilirubin excretion. Conversely, constitutive androstane receptor (CAR), encoded by nuclear receptor subfamily 1, group I, member 3 (NR1I3) gene, regulates bilirubin excretion by activating the components of the bilirubin clearance pathway. Thus, genetic variants in UGT1A1 and NR1I3 genes may modulate bilirubin excretion and lead to NNJ. This study aimed to determine the association between UGT1A1 and NR1I3 genetic variants and NNJ development in Malay population by genotyping the DNA isolated from buccal swabs. The accuracy and reliability of the genotyping results produced by buccal DNA was also compared with that of the whole blood DNA. Methods Buccal swabs were collected from 232 hyperbilirubinemia and 232 non-hyperbilirubinemia newborns admitted to and/or born in Hospital Universiti Sains Malaysia (HUSM). Hyperbilirubinemia subjects were those with TSB levels ≥250 µmol/L within the first week after birth while non-hyperbilirubinemia subjects were newborns without significant hyperbilirubinemia. The UGT1A1 (c.211G>A) and NR1I3 [MPJ6_1I3008 (G>A), IVS8+116T>G and 540A>G] variants were genotyped by using high resolution melting (HRM) analysis. Binary logistic regression was used to assess the association between variant genotypes and risk of NNJ. Whole blood samples were also collected from 60 subjects and genotyped to compare the HRM genotyping results with that of the buccal swabs. Results When compared with wild-type genotype, both heterozygous and homozygous variant genotypes of MPJ6_1I3008 (G>A), IVS8+116T>G and 540A>G were not significantly associated with NNJ. However, the heterozygous genotype (GA) of c.211G>A was found to increase the

  11. Deduction of Resistant Genotype of 211 Rice Varieties against Magnaporthe oryzae in Jiangxi Province%江西省水稻主要品种抗瘟基因型的推导

    李湘民; 吴淑秀; 兰波; 何烈干

    2011-01-01

    利用22个稻瘟病菌鉴别菌株,采用离体叶段接种,测定江西省211个水稻品种的抗瘟基因型.根据试验结果的推导,供试品种分别含有1~6个不等的抗瘟基因,共分为30个类群.其中含1,2和3个基因的品种数分别为130,41和29个,所占比例分别为61.61%,19.43%和13.74%;而含4~6个基因的品种数总共11个,所占比例为5.21%.表明江西省绝大多数水稻品种,含1~3个抗瘟基因.211个品种总共推导出18个抗瘟基因,从基因出现的频率来看,频率大于5%的基因有9个,分别是Pi-sh、Pi-km、Pi-ta2、Pi-9 、Pi-5、Pi-z、Pi-3、Pi-1、Pi-kh,其中又以Pi-kh频率最高,为62.09%;Pi-ta、Pi-kp、Pi-12、Pi-zt、Pi-b、Pi-7、Pi-20、Pi-11、Pi-z5 9个抗瘟基因出现频率均在5%以下;此外,Pi-a、Pi-k、Pi-ks、Pi-19、Pi-i、Pi-t 6个抗瘟基因型在供试水稻品种中均未检测到,这些结果为江西省水稻抗瘟品种的选用及合理布局提供了依据.%Deduction of blast - resistant genes of 211 rice varieties collected from Jiangxi in 2009 was conducted by in vitro inoculation of rice leave segments, using 22 rice blast ( Magnaporthe oryzae) differential isolates.18 resistant genes were deduced in the 211 rice varieties, of 18genes, the appearance frequencies of 9 genes i.e.Pi - sh , Pi - km , Pi - ta2 , Pi-9, Pi-5, Pi-z, Pi-3, Pi-1, Pi-kh,were above5%, of them, the Pi - kh was of the highest appearance frequency of 62.09%.those of 9 genes i.e.Pi - ta, Pi - kp,Pi - 12, Pi - zt , Pi - b, Pi - 7, Pi - 20, Pi - 11, Pi - z5 were below 5 %.Six genes i.e.Pi - a, Pi - k, Pi -ks, Pi - 19, Pi -i, Pi -t were not detected in the tested varieties.The results provide a basis for choosing new blast- resistant varieties and their rational distribution.

  12. 我国图书馆集成系统迁移浪潮研究——以“211”高校图书馆为例%Research on Immigration of Integrated Library System in China

    陈定权; 张雪成

    2012-01-01

    The development of library automated system in China has experienced the change from multi-service system to integrated system, low-end system to high-end system and the "host-terminal" architecture to the C'S and BIS architecture. The paper analyzes the migration wave of library automation systems in the mid-1990s and early 21 st century in China, and points out that the library is ongoing a new round of migration wave based on the integrated library systems adopted in "211" Universities. Finally, the paper predicts the impact of cloud computing on integrated library system and a new round of migration.%我国图书馆自动化系统前后经历了多业务功能系统到集成系统、低端系统到高端系统、由“主机-终端”架构向C/S和B/S架构的转变.文章分析出我国图书馆自动化系统在20世纪90年代中期和21世纪初的两次迁移浪潮,结合我国“211”高校图书馆集成系统采用情况,指出我国图书馆正在进行新一轮系统迁移浪潮.文章最后预测云计算对图书馆集成系统以及新一轮系统迁移的影响.

  13. Clinical efficacy of paclitaxel combined with platinum regimen on patients with advanced cervical cancer and the effect on serum CYFRA21-1, SCC-Ag%紫杉醇联合铂类方案治疗中晚期宫颈癌患者的临床疗效及对血清 CYFRA21-1、SCC-Ag 的影响

    高琴; 张丹丹; 白帆; 罗芳; 李芳兵

    2015-01-01

    目的:探讨紫杉醇联合铂类方案治疗中晚期宫颈癌患者临床疗效及对CYFRA21-1、SCC-Ag的影响。方法中晚期宫颈癌患者104例随机分为观察组和对照组各52例,观察组应用紫杉醇联合铂类方案治疗,对照组应用伊立替康联合铂类方案治疗。观察2组的临床疗效、不良反应及生存质量,并对比血清肿瘤标记物CYFRA21-1、SCC-Ag变化情况。结果观察组有效率67 J.3%(35/52)高于对照组44.2%(23/52)(χ2=10.815, P <0.05)。治疗后2组CYFRA21-1、SCC-Ag均较治疗前降低[(2.12±1.03)vs.(4.56±2.07)、(1.67±1.04)vs.(3.85±1.17)]( P均<0.05),且观察组低于对照组( t =7.409、9.439, P <0.05)。治疗后,2组躯体功能、情绪功能、社会功能、疲乏、食欲减退、疼痛方面均改善(观察组t =3.759、3.964、3.738、3.316、3.670、3.057,对照组t =3.251、2.341、2.465、1.906、2.590、2.317, P均<0.05),且除躯体功能方面外、以上其余方面观察组均优于对照组( t =1.661、1.928、1.764、1.838、1.554, P均<0.05),消化道反应、骨髓抑制、肌肉关节疼痛、白细胞下降、血小板下降发生率观察组明显低于对照组(χ2=3.898、2.797、6.522、4.300、2.659, P均<0.05),呼吸困难、脱发、肝肾功能损伤发生率方面,2组比较差异无统计学意义(χ2=0.210、0.070、0.153, P >0.05)。结论紫杉醇联合铂类方案治疗中晚期宫颈癌疗效确切、有效率高、不良反应少、能延长患者生存时间、提高患者的生存质量,值得临床推广应用。%Objective To explore the effect of paclitaxel plus platinum regimen in the treatment of advanced cervical cancer patients and effect on CYFRA 21-1, and SCC-Ag.Methods Advanced cervical cancer of 104 cases were randomly di-vided into observation group and control group with 52 cases in each group , the observation group used

  14. 两岸大学生就业状况的性别差异探讨——基于大陆7所211高校与台湾10所高校的调查数据%Gender differences in college student employment Between Taiwan and the Mainland——Based on the Survey of Seven"211"Universities in Wuhan and Ten Universities in Taiwan

    王俊; 郭梦珂

    2015-01-01

    Based on the survey data of seven"211"universities in mainland China and ten universities in Taiwan, there are gender differences in cross-strait college student employment. The girls have advantages over boys in such areas as student cadres service, practical experience at work and so on. However, the boys show more confidence in judging employment situation and prospects leading to more interview opportunities. The comparison also reveals significant gender difference in terms of interview results, employment reasons, company type and salary. Especially in the Mainland , the gender discrimination has more serious influence . Despite gender differences in the college student employment in Taiwan,, college students rarely report gender discrimination and believe that gender is not a vital factor in employment. How to explain the fact and experience of gender differences in cross-strait college student employment , and how to reasonably design a comprehensive and cross-border program to eliminate gender discrimination in college student employment? We are trying to explore more deeply%基于大陆7所211高校与台湾10所高校的调查数据显示:两岸大学生就业普遍存在性别差异.在个人特征方面,两岸女生在担任学生干部、工作实践经验等方面都优于男生,但在对就业前景和就业形势的判断上,男生比女生更自信,就业过程中获得面试机会也更多,且在签约结果、签约原因、签约单位的性质、薪资差距等方面性别差异显著.特别是大陆地区就业性别歧视程度及就业结果与性别之间存在更为显著的相关;而台湾地区大学生就业虽存在性别差异,但大学生对就业中的性别歧视普遍感受不明显,且不认为性别是影响就业的一个重要因素.如何解释两岸大学生就业性别差异的事实与经验,合理设计消除大学生就业性别歧视的跨界别全面方案仍需要进一步探索.

  15. Synthesis, molecular structure, spectroscopic investigations and computational study of a potential molecular switch of 2-([1,1'-biphenyl]-4-yl)-2-methyl-6-(4-nitrophenyl)-4-phenyl-1,3 diazabicyclo [3.1.0]hex-3-ene

    AYOUB KANAANI; DAVOOD AJLOO; HAMZEH I KIYAN; FRESHTE SHAHERI; MAJID AMIRI

    2016-08-01

    This work presents a combined experimental and theoretical study on a photochromic compound, 2-([1,1'-biphenyl]-4-yl)-2-methyl-6-(4-nitrophenyl)-4-phenyl-1,3 diazabicyclo [3.1.0]hex-3-ene, existing in closed form (‘A’) and open form (‘B’). The spectroscopic properties of the title compound have beeninvestigated by using IR, UV–Vis and ¹H NMR techniques. The molecular geometry and spectroscopic data of the title compound have been calculated by using the density functional method (B3LYP) invoking 6-311G(d,p) basis set. UV-Vis spectra of the two forms were recorded. The excitation energies, oscillator strength, etc., were calculated by time-dependent density functional theory (TD-DFT). Furthermore, molecular electrostatic potential map (MEP), frontier molecular orbital analysis (HOMO–LUMO), total density of state (TDOS) and reactivity descriptors were found and discussed. We applied a first-principles computational approach to study a light-sensitive molecular switch. We find that the conductance of the two isomers varies dramatically, which suggests that this system has potential use as a molecular switch.

  16. Probing the jet base of the blazar PKS1830-211 from the chromatic variability of its lensed images. Serendipitous ALMA observations of a strong gamma-ray flare

    Marti-Vidal, I; Combes, F; Aalto, S; Beelen, A; Darling, J; Guelin, M; Henkel, C; Horellou, C; Marcaide, J M; Martin, S; Menten, K M; Dinh-V-Trung,; Zwaan, M

    2013-01-01

    The launching mechanism of the jets of active galactic nuclei is observationally poorly constrained, due to the large distances to these objects and the very small scales (sub-parsec) involved. In order to better constrain theoretical models, it is especially important to get information from the region close to the physical base of the jet, where the plasma acceleration takes place. In this paper, we report multi-epoch and multi-frequency continuum observations of the z=2.5 blazar PKS1830-211 with ALMA, serendipitously coincident with a strong $\\gamma$-ray flare reported by Fermi-LAT. The blazar is lensed by a foreground z=0.89 galaxy, with two bright images of the compact core separated by 1". Our ALMA observations individually resolve these two images (although not any of their substructures), and we study the change of their relative flux ratio with time (four epochs spread over nearly three times the time delay between the two lensed images) and frequency (between 350 and 1050 GHz, rest-frame of the blaz...

  17. Coarctation of the aorta and mild to moderate developmental delay in a child with a de novo deletion of chromosome 15(q21.1q22.2

    Peters Sarika U

    2006-02-01

    Full Text Available Abstract Background Deletion of 15q21q22 is a rare chromosomal anomaly. To date, there have been nine reports describing ten individuals with different segmental losses involving 15q21 and 15q22. Many of these individuals have common features of growth retardation, hypotonia and moderate to severe mental retardation. Congenital heart disease has been described in three individuals with interstitial deletion involving this region of chromosome 15. Case presentation We report a child with coarctation of the aorta, partial agenesis of corpus callosum and mild to moderate developmental delay, with a de novo deletion of 15q21.1q22.2, detected by the array Comparative Genomic Hybridization (CGH. We utilized chromosome 15-specific microarray-based CGH to define the chromosomal breakpoints in this patient. Conclusion This is the first description of mapping of an interstitial deletion involving the chromosome 15q21q22 segment using the chromosome 15-specific array-CGH. The report also expands the spectrum of clinical phenotype associated with 15q21q22 deletion.

  18. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  19. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the success of {sup 225}Ac radioimmunotherapy.

  20. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.