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Sample records for accords conclus par

  1. Conclusion

    Tate, Georges

    2013-01-01

    Entre le IVe et le VIe siècle, l'évolution du Massif calcaire est marquée par un puissant contraste. D'un côté, le cadre de la vie des hommes demeure stable : même prédominance de l'habitat groupé, pratique conjointe de l'autoconsommation et de la production pour la vente, répartition des hommes dans des groupes domestiques d'inégale extension. Mais, d'un autre côté, de grands changements se produisent : multiplication par trois ou par quatre du nombre des hommes, accroissement de la producti...

  2. Conclusion

    Dubreuil-Chambardel, Pierre

    2013-01-01

    Dans une lettre du 11 Septembre 1793, Pierre Dubreuil Chambardel écrit à son propos cette phrase: "Ciil a fait peu aumoins atilfait touts ce quil apu par conséquand rempli sa missive". Une telle remarque est tout à fait significative de l'état d'esprit du député poitevin. Lucide, il est conscient du rôle effacé qu'il tient dans l'aventure révolutionnaire, ainsi que de sa place au sein de cette force silencieuse représentée par la majorité des députés. Ni orateur brillant, ni écrivain chevronn...

  3. Conclusion

    Guinle, Francis

    2011-01-01

    L’étude littéraire de la recension damascène de Sīrat al-Malik al-Ẓāhir Baybarṣ présente un intérêt indéniable pour plusieurs raisons. D’abord parce qu’il s’agit d’un manuscrit de ḥakawātī, c’est-à-dire qui procède d’une tradition vivante et d’une reconstitution de l’histoire par un conteur qui puise dans plusieurs grands manuscrits de la Sīra sur une période qui couvre vraisemblablement un siècle. Ensuite parce qu’il s’agit de la dernière recension de la Sīra, le manuscrit le plus récent uti...

  4. Conclusion

    Hebbelinck, Thérèse

    2013-01-01

    Ce que révéla l’affaire du carmel L’affaire du carmel d’Auschwitz révéla avant tout des conceptions fondamentalement différentes entre juifs et chrétiens. Les catholiques polonais qui avaient encourage la création d’un carmel a Auschwitz souhaitaient que ce lieu de souffrance récupéré par le pouvoir communiste athée depuis la fin de la Seconde Guerre mondiale devienne un lieu d’expiation et de prière. Cette idée était à l’opposé de la conception juive qui voyait en Auschwitz un non-sens et un...

  5. Conclusions

    Carr, Alan.

    2002-01-01

    In order to identify effective prevention programmes we reviewed over 200 studies involving more than 70,000 children. Furthermore, the studies we selected for review were the most methodologically robust that we could find using both computer and manual searches of the English language literature for the past quarter of a century. We can therefore place considerable confidence in our conclusions which are summarized in this chapter. Our conclusions concern the prevention of the following lis...

  6. Conclusion

    Sandøy, Helge; Kristiansen, Tore

    2010-01-01

    1. Comparing empirical findings with the “mountain peak model” In the introduction to this volume, we presented a “mountain peak model” of Nordic purism based on evidence showing that language scholars and lay people are very much in agreement as to where we find the more purist languages and......-speaking Finland to Finnish-speaking Finland. In this conclusion to the volume, we will summarize the empirical findings presented in the volume, findings for use and attitudes alike, and compare them with the mountain peak model. That way, we may be able to estimate the nature of the cross-national ideological...

  7. Conclusion

    Georgina Holt

    2007-04-01

    Full Text Available Articles of this special issue highlighted several different but complementary aspects linked to local and locally made products. The first part of the conclusion is directly oriented towards the concept of local food, its use and definition: local food is obviously a pluri-dimensional concept. The second part looks at the conceptual frameworks employed to deconstruct and understand the meaning of local food by various authors. In the third and final part we look again at the impact on and in...

  8. Les défis lancés par l’accord TRIPS aux pays en développement

    Keim, Nadine

    2012-01-01

    Avec l’Organisation mondiale du commerce (OMC), les pays du Sud n’ont plus la possibilité de choisir d’imiter les techniques créées par d’autres. Au-delà de quelques exceptions, l’accord TRIPS prévoit la protection des inventions technologiques par un brevet. En outre, il oblige à breveter les micro-organismes, ainsi qu’à protéger d’une façon ou d’une autre les variétés végétales. Dorénavant, la seule propriété intellectuelle au monde non protégée, ce sont les connaissances traditionnelles du...

  9. Sweet Conclusion

    Shirley, Britt M.; Wooldridge, Barbara Ross; Camp, Kerri M.

    2012-01-01

    Jen Harrington is the owner and pastry chef of Sweet Conclusion, a bakery in Tampa, Florida. Most of Harrington's business comes from baking wedding cakes, but she has been attempting to attract customers to her retail bakery, where she sells cupcakes, pies, ice cream, and coffee. Nearly four years she opened Sweet Conclusion, the retail part of…

  10. Conclusions of the Workshop

    The overall conclusion of this workshop was that the SNS synchrotron, operated in storage ring mode at its 70 MeV injection energy, is almost ideally suited to simulating many of the experiments vital to establishing the feasibility of HIF storage ring drivers and that no other existing accelerator system seems able to match this capability. During the meeting items of equipment required to carry out satisfactory HIF simulation experiments were identified and a 5 year programme, with costing quoted at 1981/82 prices, was drawn up. The prospect of international participation in these experiments was examined. (U.K.)

  11. Conclusions and lessons learned

    This study is the third in a series of national studies conducted under a unique partnership initiative officially registered with the United Nations Commission on Sustainable Development by the IAEA, in cooperation with participating Cuban organizations and the United Nations Department of Economic and Social Affairs. Similar studies for Brazil and South Africa were completed in 2006. This section presents the main conclusions derived from this comprehensive assessment of the Cuban energy system performed within a sustainable development framework. It also outlines 'other accomplishments' of, and 'lessons learned' from, the cooperative effort conducted jointly by Cuban and international experts. It concludes with some reflections about 'next steps' that may be followed to continue advancing the concepts and ideas supporting sustainable development at the national and international levels

  12. Summary and Conclusions

    This section summarizes the presentations and Panel discussions of the 4 technical sessions of the workshop: 1 - Regulatory cooperation on generic and design specific issues, MDEP working groups (EPR, AP1000), vendor inspection co-operation, digital I and C, and codes and standards (7 presentations); 2 - Regulatory positions on siting practices and enhancements as a result of lessons learned from Fukushima accident (5 presentations); 3 - Construction experience and regulatory oversight of new reactor construction activities (6 presentations); 4 - Lessons learned from regulatory licensing reviews of new reactor designs (6 presentations). The main workshop conclusions are listed as follows: - Harmonization is a long term goal and significant progress has been made. However, this long term objective needs to be associated with short term measurable steps; - MDEP approach to tackle on one side with specific technical subjects, and to strive harmonisation on generic topics was considered appropriate; - Convergence on technical requirements is more realistic than harmonization of codes and standard; - Beneficial early engagement of different stakeholders specially at the siting stage has been acknowledged; - Need to characterise the hazards and to keep updated the safety assessment (PSR); - Land use issues are important particularly after Fukushima; - Commissioning aspects (e.g. training aspects for inspectors) should be addressed by WGRNR taking into account MDEP interaction; - Importance of WGRNR ConEx Programme: construction experience sharing is a leverage for quality and so for a future safe operation of NPPs; - Capability of licensee to follow the responsibility of design changes (could be an issue for small utilities); - Importance of Periodic Safety Reviews to review and account for the design. Finally, the WGRNR has convened that a third conference should be held in about two years time (2014- 2015)

  13. Conclusions and recommendations

    I - Seismic re-evaluation conclusions: 1. Seismic re-evaluation is not the same as design. The allowable limits and acceptance criteria can go beyond design criteria, provided the safety is not compromised. 2. Displacement based and some non-linear analysis methods are encouraged for seismic reevaluation. 3. Users of experience based methods, such as SQUG, should make sure the data is applicable to their specific case. Implementers of the re-evaluation should have suitable knowledge and experience. They must be trained and qualified to perform the tasks. 4. Test results and post earthquake field investigations are of great importance for seismic reevaluation. They provide much of the information which underlies the processes used. 5. Seismic re-evaluation should make full use of as-built information and data should be verified on site as far as possible. 6. A peer review is strongly recommended as part of seismic re-evaluation. To deliver maximum benefit, it should be concurrent with the re-evaluation. 7. To improve the seismic input from reviewed earthquakes, it is necessary to fully capture the existing uncertainties and these need to be incorporated into the state of the art of the knowledge to characterize the sources, attenuation and site effects. 8. Following re-evaluation, any changes or modifications should take into account safety benefits and potential detriments. II - General recommendations on seismic design and re-evaluation: 1. Human factors, housekeeping and training are important throughout the life of the facility. The seismic safety case needs to be maintained to ensure interaction hazards (eg unlocked cranes, unsecured containers,..) are not introduced between periodic walk-downs and inspections. 2. Pre-earthquake preparations need more attention, particularly the selection and recording of damage indicators which aid post earthquake decision making. A database of information collected from walk-downs (related to the condition of the plant) to

  14. Conclusion

    Essential part in water pollution by heavy metals, fluorides, chlorine, oil products and other harmful matters falls on plant of non-ferrous metallurgy and chemical industry. Big specter of contaminants falls on housing and communal services and faults of medical establishments. Based on above-stated the receiving of high-effective coagulants for water purification is the actual and important object

  15. Conclusion

    Šimon, Martin; Mikešová, Renáta

    Prague: Institute of Sociology , Academy of Sciences of the Czech Republic, 2014 - (Šimon, M.; Mikešová, R.), s. 115-118 ISBN 978-80-7330-257-3 Institutional support: RVO:68378025 Keywords : population development * demography * Central Europe Subject RIV: AO - Sociology , Demography

  16. Conclusions

    Poláček, Lumír

    Brno: The Institute of Archaeology of the Academy of Sciences of the Czech Republic, Brno, 2014 - (Poláček, L.), s. 143-145. (Spisy archeologického ústavu AV ČR Brno. 51). ISBN 978-80-86023-60-1 R&D Projects: GA ČR(CZ) GAP405/11/2258 Keywords : river archaeology * geoarchaeology * Bridge No. 1 * Early Middle Ages * Mikulčice Subject RIV: AC - Archeology, Anthropology, Ethnology

  17. Conclusion

    Ivancevic, Vladimir G.; Reid, Darryn J.

    2015-11-01

    It is often held that things should always be made simple, which presumes that either that they can always be made simple or that all the jetisoned logic doesn't matter anyway. Alledgedly, anything should be explainable so that anyone can understand it. Don't get bogged down in dreary details. It should be effortless for the reader: low-dimensional systems exhibit complex behaviour while high-dimensional systems exhibit simple behaviour (to return to our prolegomonal opening), competition is a universal solution, demand must increase as price falls, and everything under the sun neatly fits a power law. Or so the story goes...

  18. Conclusion

    Thoma, Klaus; Hiller, Daniel; Leismann, Tobias; Drees, Birgit

    Considering the breadth of perspectives in security research among Europeans, as exemplified within this publication, one may certainly note that a tremendous development of this young discipline has occurred in a short period of time. Only three years have passed since the discipline was promoted to an individual theme within the specific programme on `Cooperation' of the European Commission FP7. Since then, a conceptual framework has been established and the first collaborative projects have been executed on different levels, all at an impressive pace. Although the future of security research will remain closely linked to the political will of EU member states, the established base will serve as a solid foundation for the further development of the discipline on a European scale.

  19. Conclusion

    Loriot, François; Plantey, Alain

    2016-01-01

    Le resserrement des relations entre les États souverains, ainsi que l’accroissement des échanges internationaux accroissent le nombre et renforcent l’utilité des organisations internationales. Celles-ci, malgré d’incontestables et périodiques difficultés politiques et financières, développent une administration de plus en plus étendue, coûteuse, perfectionnée, dont les réglementations, les moyens, les personnels se différencient et s’étoffent. Quelles que soient leurs idéologies et leurs riva...

  20. Conclusion

    Viaud, Ronan

    2015-01-01

    Au début des années 1950, le syndicalisme maritime s’est imposé comme un interlocuteur incontournable pour l’État et le patronat. Les différentes organisations syndicales représentatives participent au Comité central des pêches maritimes et au Conseil supérieur de la marine marchande, ainsi qu’au conseil d’administration des deux compagnies de navigation dont l’État est l’actionnaire majoritaire. Des conventions collectives nationales encadrent les relations entre les organisations syndicales...

  1. Conclusions

    Cassata, Francesco

    2013-01-01

    The eugenic gospel spread in Italy in the late nineteenth and early twentieth centuries, providing a scientific solution for the profound political, economic and social problems characterizing a country that had achieved political unification only in 1871. The construction of a national identity, social cohesion, and the problem of emigration were as central to eugenics as they were to other social and political movements. In 1912, the Italian delegation at the First International Eugenics Co...

  2. Conclusion

    Arnold, Steven M.; Wong, Terry T.

    2011-01-01

    This compilation of papers in this book represents approximately half of the works discussed at the MS&T 2010 symposium entitled Tools, Models, Databases, and Simulation Tools Developed and Needed to Realize the Vision of Integrated Computational Materials Engineering at Materials Science & Technology wherein five sessions comprised of 33 presentations was organized. The goal of the symposium was two fold To provide a forum in which current state-of-the-art methods for ICME (e.g., information informatics, experimentation, and modeling) could be openly discussed and critiqued by not only materials scientist but also structural engineers/researchers, component designers, industrial leaders and government program managers. To leave the symposium and in particular the panel discussion with a clear idea of the gaps and barriers (both technical, cultural and economical) that must be addressed in order for ICME to fully succeed. The organizers felt that these goals were met, as particularly evident by the standing room only attendance during a lively panel discussion session at the end of the Symposium. However it is the firm belief of the editors of this book that this symposium was merely a start in the right direction, and that subsequent conferences/symposium (e.g., First World Congress on Integrated Computational Materials Engineering to be held July 10-14, 2011 at Seven Springs Mountain Resort in Pennsylvania) must work hard to ensure that a truly diverse, multidisciplinary, community of researchers and practitioners are present and have ample opportunity for interaction. This will ensure that a proper balance between push and pull disciplines and technologies is maintained so that this emerging focus area, Integrated Computational Materials Engineering (ICME), has the greatest potential for success and impact on "system-level" payoffs. Similarly, a pro-active approach is required to reform historical modes of operation in industry, government and the academic sectors so as to facilitate multidisciplinary collaboration and to clearly articulate the vision and scope of ICME.

  3. Conclusions

    GOLINVAL, JC; G. Kerschen; V. Lenaerts; Thouverez, F.; Argoul, P.

    2003-01-01

    The main feature of the COST F3 Working Group was to identify structures that exhibit a non-linear behaviour. In this context, two benchmarks were proposed, namely, the VTT benchmark and the ECL benchmark.

  4. Conclusion

    2004-01-01

    @@ One of the major contributions of economic integration to European unification lies in its transformation of traditional European balance concepts and structures. This unification model shows that mere economic and trade ties cannot basically change state relations.

  5. Conclusion

    Cassuto, Philippe

    2013-01-01

    Nous aimerions que cet ouvrage ne soit que le début de la publication du commentaire biblique du TTP, il reste en effet dix-neuf autres chapitres à traiter. Sur les près de quatre cents citations bibliques du TTP, nous en avons présenté ici environ une soixantaine. Le second chapitre du TTP nous apparaît comme l’étape suivante du fait du grand nombre de citations bibliques qui y sont insérées. Les derniers chapitres du TTP comportent moins de citations jusqu’à disparaître vers la fin de l’ouv...

  6. Conclusions

    Kahiluoto, Helena; Vesala, Kari

    2006-01-01

    There is good potential for sustainable localisation and recycling in rural food systems around the Baltic Sea. Localisation and recycling enhance sustainability in its ecological, economic and social dimensions. A sustainable way of localisation and recycling would be local recycling between farms and from the demand chain.

  7. Conclusions

    The results of conducted studies are considered. It is defined that high molecular compounds of petroleum of Kichik-Bel deposit decrease the thermal-oxidative processes. It is found that lube fraction of petroleum of Kichik-Bel deposit increases the extraction of bitumen from the old asphalt-concrete and recovers its properties. It is defined that petroleums of South of Tajikistan are effective corrosion inhibitors.

  8. Conclusion

    Eury, Pascaline

    2014-01-01

    Le roi Hussein comptait sur les élections législatives du 8 novembre 1989 pour retrouver le soutien de son peuple, et plus particulièrement celui de ses sujets traditionnellement les plus fidèles, et renforcer sa légitimité dans un contexte intérieur difficile, où les marges de manœuvre dans tous les domaines sont étroites, et dans un contexte régional et international encore plus aléatoire. Les différentes estimations concernant les résultats de ces élections ne faisaient que confirmer cet e...

  9. Conclusion

    Langlois, Charles-Victor; Seignobos, Charles

    2014-01-01

    I. L’histoire n’est que la mise en œuvre de documents. Or il dépend d’accidents fortuits que les documents se soient conservés ou se soient perdus. De là, dans la constitution de l’histoire, le rôle dominant du hasard. La quantité des documents qui existent, sinon des documents connus, est donnée ; le temps, en dépit de toutes les précautions qui sont prises de nos jours, la diminue sans cesse ; elle n’augmentera jamais. L’histoire dispose d’un stock de documents limité ; les progrès de la sc...

  10. Conclusion

    In Asia, Japan and the Republic of Korea have conducted similar studies but relying on statistical data and used inputs and outputs (I-O) methodology, utilizing on general macro-level data. In contrast, this study captures data directly through surveys using questionnaires, face-to-face interviews, case studies and focus group discussions. The impact of nuclear technology applications in Malaysia were evaluated both quantitatively and qualitatively. These impacts are then linked to a broader objective associated with technological development, namely wealth generation, knowledge generation and societal well-being. In the process of the study, users and practitioners of the technology highlighted issues and challenges faced by them. To cap the study, the level of activities of nuclear technology in Malaysia was benchmarked against those in Japan and the Republic of Korea. This chapter highlights the results of the study, the outcome of the study, followed by recommendations as response to issues and challenges raised by respondents, and finally the way forward for monitoring and charting further progress of nuclear technology in the country. (author)

  11. Conclusion

    Manners, Ian James; Whitman, Richard; Hadfield, Amelia

    2015-01-01

    The stakes have never been higher for the European Union. Its very distinctiveness – twenty-eight separate national units morphed into an inelegant but powerful over-arching supra-national institutional framework – now appear to have less, rather than more in common. Member States’ own quarrelsom...

  12. Conclusion

    Finnegan, Ruth

    2014-01-01

    Several points emerge from this examination of oral literature in Africa. The first is an obvious one. This is the relevance of African oral literature for comparative literature in the wide sense. The study of the kinds of instances and genres touched on in this account can enlarge both our literary experience and our concept of ’literature’ altogether. It can also throw light on some recent literary experiments (jazz poetry, for instance) as well as on the oral background to literature even...

  13. Conclusion

    Bohlinger, Sandra; Haake, Ulrika; Jørgensen, Christian Helms;

    2015-01-01

    Work in times of globalisation and uncertainty is undergoing considerable changes, which has strengthened the importance of work as a site of learning. New trends in production, such as digitalisation, challenge traditional modes of producing goods and services. Emerging forms of flexible...... chains. This book explores the challenges of working and learning on the boundaries between education and working life. Globalisation affects the transition patterns from vocational education to the labour market in many ways (Schoon & Silbereisen, 2009), even though the specific challenges to national...

  14. Conclusion

    Haggenmacher, Peter

    2014-01-01

    Ha indicato una strada, di cui molto probabilmente egli stesso non fu del tutto consapevole.Norberto Bobbio Eine Wurdigung der Gesamtleistung des Grotius kann, wie seit langem erkannt ist, nicht auf seinem traditionellen Ruhm seit der Aufklärung beruhen, die ihn zu einem Gründungsheros gemacht hat und daher anachronistisch, nicht aus seinen eigenen Voraussetzungen interpretieren und würdigen musste.Franz Wieacker Die Ursprünglichkeit geistiger Leistungen wird heute noch falsch eingeschätzt. D...

  15. Conclusion

    Desbois, Evelyne; Jeanneau, Yves; Mattéi, Bruno

    2014-01-01

    Le procédé utilisé dans cette recherche est analogue à une technique de fonte, la cire perdue : se servir de l’enveloppe extérieure pour façonner en creux les contours de l’objet à reproduire. La parole des mineurs faisant défaut sur le déroulement et le sens de la bataille du charbon, nous en avons recherché les traces auprès de ceux qui les encadraient alors. Leurs témoignages ainsi que les archives dessinent un paysage social discordant. D’un côté les responsables politiques et les cadres ...

  16. Conclusion

    Godard, Henri René

    2015-01-01

    Hemos tratado de evidenciar los puntos en común y las diferencias que permiten explicar los mecanismos de evolución de los barrios populares de las dos metrópolis del país; es evidente que las conclusiones emitidas a partir de las ocho zonas de estudio seleccionadas no pueden generalizarse a la totalidad de los barrios populares quiteños y guayaquileños. Antes que insistir en la noción de velocidad de consolidación y de tugurización, nos parece interesante presentar de una manera sintética lo...

  17. Conclusion

    Garrett, Geoffrey; Dobbin, Frank; Simmons, Beth Ann

    2008-01-01

    The diffusion of markets and democracy around the world was a defining feature of the late twentieth century. Many social scientists view this economic and political liberalization as the product of independent choices by national governments. This book argues that policy and political changes were influenced heavily by prior actions of external actors: not just other governments, but international organizations and communities of experts. Drawing together insights from economics, sociology, ...

  18. Conclusion

    Šída, P.; Nývltová Fišáková, Miriam

    Brno: Academy of Sciences of the Czech Republic, Institute of Archaeology at Brno, 2009 - ( Šída , P.), s. 245-250. (Dolnověstonické studie. 17). ISBN 978-80-86023-86-1 R&D Projects: GA AV ČR KJB800010701 Institutional research plan: CEZ:AV0Z80010507 Keywords : Mammals * Pleistocene * Prey * Gravettien * Bohemia Subject RIV: AC - Archeology, Anthropology, Ethnology

  19. ViPAR

    Carter, Kim W; Francis, Richard W; Bresnahan, M; Gissler, M; Grønborg, T K; Gross, R; Gunnes, N; Hammond, G; Hornig, M; Hultman, C M; Huttunen, J; Langridge, A; Leonard, H; Newman, S; Parner, E T; Petersson, G; Reichenberg, A; Sandin, S; Schendel, Diana; Schalkwyk, L; Sourander, A; Steadman, C; Stoltenberg, C; Suominen, A; Surén, P; Susser, E; Sylvester Vethanayagam, A; Yusof, Z

    2015-01-01

    free and open source methods to provide researchers with a web-based platform to analyse datasets housed in disparate locations. METHODS: Database federation permits controlled access to remotely located datasets from a central location. The Secure Shell protocol allows data to be securely exchanged......PAR infrastructure, remote sites manage their own harmonized research dataset in a database hosted at their site, while a central server hosts the data federation component and a secure analysis portal. When an analysis is initiated, requested data are retrieved from each remote site and virtually pooled at the...... central site. The data are then analysed by statistical software and, on completion, results of the analysis are returned to the user and the virtually pooled data are removed from memory. CONCLUSIONS: ViPAR is a secure, flexible and powerful analysis platform built on open source technology that is...

  20. Chapter 6: Conclusions and recommendations

    This chapter provides a brief summary of conclusions with respect to project implementation issues. Furthermore, the chapter contains recommendations on future applications of the modelling system and on water resources management in the project area

  1. The Expression of the Thrombin Receptors PAR-3 and PAR-4 is Downregulated in Pancreatic Cancer Cell Lines

    Claudia Rudroff

    2015-05-01

    Full Text Available Background: Patients with pancreatic cancer frequently suffer from thrombosis as a consequence of excess thrombin generation. In addition to its role in the plasmatic coagulation cascade, thrombin induces numerous cellular effects by activating a unique group of G-protein-coupled receptors on the cell membrane, the proteinase-activated receptors (PARs. At present, PAR-1, PAR-3 and PAR-4 are known to be activated by thrombin. We previously demonstrated a putative role for PAR-1 in pancreatic cancer progression, but little is known about the physiological and pathophysiological roles of PAR-3 and PAR-4. In the present study, we examined the expression patterns of PAR-3 and PAR-4 in pancreatic tissue and pancreatic cancer cells. Methods: Tissue samples from three patients with pancreatic adenocarcinoma and six human pancreatic carcinoma cell lines were examined. Gene expression was analysed by RT-PCR and quantified by HPLC. Protein expression was determined by Western blot analysis. Data analysis was performed using ANOVA in SPSS. Results and Conclusion: In contrast to PAR-1, both PAR-3 and PAR-4 were expressed in healthy pancreases but downregulated in pancreatic cancer. The contrasting expression patterns of PAR-3 and PAR-4 compared with PAR-1 indicate that the mechanism that regulates the cellular effects of thrombin on tumor progression remains to be fully elucidated.

  2. Par Pond water balance

    A water budget for the Par Pond hydrologic system was established in order to estimate the rate of groundwater influx to Par Pond. This estimate will be used in modeling exercises to predict Par Pond reservoir elevation and spillway discharge in the scenario where Savannah River water is no longer pumped and discharged into Par Pond. The principal of conservation of mass was used to develop the water budget, where water inflow was set equal to water outflow. Components of the water budget were identified, and the flux associated with each was determined. The water budget was considered balanced when inflow and outflow summed to zero. The results of this study suggest that Par Pond gains water from the groundwater system in the upper reaches of the reservoir, but looses water to the groundwater system near the dam. The rate of flux of groundwater from the water table aquifer into Par Pond was determined to be 13 cfs. The rate of flux from Par Pond to the water table aquifer near the dam was determined to be 7 cfs

  3. Conclusion générale

    Mattéi, Jean-Mathieu

    2015-01-01

    Le contenu et la portée du droit de la guerre tel qu’élaboré entre les années 1700 et 1819, font la preuve de toute la richesse et de la qualité d’un siècle exceptionnel dans l’histoire du droit international. Cette pensée juridique n’a ni plus ni moins que façonné la modernité du droit international. Si elle demeure redevable du travail accompli par la tradition médiévale et par celle de la Renaissance, cette somme constitue aussi, du point de vue du droit de la guerre, le dernier stade d’av...

  4. PAR1- and PAR2-induced innate immune markers are negatively regulated by PI3K/Akt signaling pathway in oral keratinocytes

    Dale Beverly A

    2010-10-01

    Full Text Available Abstract Background Protease-Activated Receptors (PARs, members of G-protein-coupled receptors, are activated by proteolytic activity of various proteases. Activation of PAR1 and PAR2 triggers innate immune responses in human oral keratinocytes (HOKs, but the signaling pathways downstream of PAR activation in HOKs have not been clearly defined. In this study, we aimed to determine if PAR1- and PAR2-mediated signaling differs in the induction of innate immune markers CXCL3, CXCL5 and CCL20 via ERK, p38 and PI3K/Akt. Results Our data show the induction of innate immunity by PAR1 requires both p38 and ERK MAP kinases, while PAR2 prominently signals via p38. However, inhibition of PI3K enhances expression of innate immune markers predominantly via suppressing p38 phosphorylation signaled by PAR activation. Conclusion Our data indicate that proteases mediating PAR1 and PAR2 activation differentially signal via MAP kinase cascades. In addition, the production of chemokines induced by PAR1 and PAR2 is suppressed by PI3K/Akt, thus keeping the innate immune responses of HOK in balance. The results of our study provide a novel insight into signaling pathways involved in PAR activation.

  5. It's quicker "Par Avignon"!

    2005-01-01

    For a few years, the CERN Library has been receiving books from the University of Hanover sent via Avignon, at least that's what it says on the envelope. Such a detour would mean that parcels were travelling 720 km more than the distance separating Geneva and Hanover, which would be a very strange state of affairs. The explanation lies in a spelling mistake. The sender has been stamping parcels with a stamp that says "Par Avignon prioritaire" (first-class via Avignon) instead of "Par Avion prioritaire" (First Class Air Mail), a source of much amusement to the librarians!

  6. Analysis of some sepsis markers: C-reactive protein, Procalcitonin, Osteopontin and suPAR

    Ilaria Crespi

    2010-09-01

    Full Text Available Sepsis appears to be due to an uncontrolled pro and anti-inflammatory response leading to organ dysfunction until shock and death.Accuracy of diagnosis and appropriate treatment affect the outcome. Aim of the study was to investigate if the levels of Osteopontin (OPN and Soluble Urokinase-type Plasminoge Activator Receptor (suPAR might be early markers of sepsis and if these markers play a role in predicting the progression to septic shock. Methods:The levels of OPN, suPAR, C-reactive protein (CRP and procalcitonin (PCT were measured in patients at higher risk of infection. The samples were collected from the day of admission for the following fifteenth day. During recovery Sistemic Inflammatory Response Syndrome (SIRS criteria, blood chemistry data, blood gas- analysis, lactate and diuresis were collected. Microbiological culture were performed according to the clinical condition. Results: 29 patients were enrolled in the study, including 14 subjects with positive blood cultures.The values of OPN, PCT, suPAR and CRP were significantly increased in patients with positive blood cultures than those with negative blood cultures.Analysing changes of the levels of OPN, suPAR, PCT and CRP in patients with septic shock, the values of OPN increased in advance to the clinical diagnosis of septic shock, while the values of suPAR and PCT slight delay compared to those OPN.The levels of CRP were independent from the onset of septic shock state. Conclusions: These preliminary data suggest that Osteopontin and suPAR can be used as early markers of sepsis and might be useful in monitoring of septic outcome to predict a possible evolution to septic shock.

  7. Conclusion générale

    Villers, Stéphanie

    2013-01-01

    L’histoire de l’avortement durant l’entre-deux-guerres est singulière. Il s’agit d’une histoire complexe et contrastée. Une histoire différente de celle du xixe siècle. En quelques décennies, une rupture d’ordre culturel se produit. La crainte de la dépopulation fait naître un moralisme étroit et outrancier au sein de l’élite. Dans les années 1920, l’idéologie nataliste conquiert une position dominante dans la sphère dirigeante de notre pays. Soutenue par la culture catholique, cette idéologi...

  8. Conclusion générale

    Gomy, Marc

    2014-01-01

    663 - Mêlant le droit civil, le droit du travail et le droit commercial, impliquant les règles de concurrence tant françaises qu’européennes, l’étude des conventions de non-concurrence représente en quelque sorte un survol du droit privé contemporain, ce qui en fait sa richesse et sa complexité. Imaginées au cours du dix-neuvième siècle pour le contrat de cession de fonds de commerce et admises sans difficulté par la jurisprudence, la tendance actuelle est à une vérification plus stricte de l...

  9. Association between competing interests and authors' conclusions

    Kjaergard, Lise L; Als-Nielsen, Bodil

    2002-01-01

    To assess the association between competing interests and authors' conclusions in randomised clinical trials.......To assess the association between competing interests and authors' conclusions in randomised clinical trials....

  10. PAR elevation influence on hydrogen floor layer depth

    In order to circumvent problems associated with containment loads resulting from a possible hydrogen combustion, French containments for instance are equipped with passive autocatalytic recombiners (PAR). The aim of this safety device is to recombine hydrogen with oxygen in order to limit hydrogen concentration. Hence, PAR distribution within the containment is a key feature to limit the hydrogen risk. According with the PARIS benchmark scenario and boundary conditions therein (EU-FP6, SARNET project) a floor layer developed with low mass and thermal mixing processes. In this paper we illustrate the link between the PAR elevation and the floor layer depth. (author)

  11. Teleportation via generalized measurements, and conclusive teleportation

    Mor, Tal; Horodecki, Pawel

    1999-01-01

    In this work we show that teleportation is a special case of a generalized Einstein, Podolsky, Rosen (EPR) non-locality. Based on the connection between teleportation and generalized measurements we define conclusive teleportation. We show that perfect conclusive teleportation can be obtained with any pure entangled state, and it can be arbitrarily approached with a particular mixed state.

  12. Effects of thrombin, PAR-1 activating peptide and a PAR-1 antagonist on umbilical artery resistance in vitro

    Elliott John T

    2005-02-01

    Full Text Available Abstract Background The non-thrombotic effects of thrombin in cardiovascular tissues, as mediated via the protease activated receptors (PARs, and particularly PAR-1, have been the focus of much recent research. The aims of this study were to evaluate the effects of thrombin, a specific PAR-1 activating peptide (PAR1-AP, and a PAR-1 antagonist on human umbilical artery tone in vitro. Methods Human umbilical artery samples were obtained from 17 women at term. Arterial rings were suspended under physiologic conditions for isometric recording. The in vitro effects of thrombin (0.5 units/mL to 3 units/mL, PAR1-AP TFLLR-NH2 [10(-9 to 10(-6 M], and PAR-1 antagonist (N-trans cinnamoyl- p-fluoroPhe-p-guanidinoPhe-Leu-Arg-Orn-NH2 [10(-9 M to 10(-5 M] on umbilical artery tone were measured. Results Both thrombin and TFLLR-NH2 exerted a potent cumulative vasodilatory effect on human umbilical artery resistance (P 0.05. Conclusion These findings highlight a potential role for thrombin and PAR-1 receptors in vascular regulation of feto-placental blood flow in normal pregnancy, and in association with the vascular lesions associated with IUGR and pre-eclampsia.

  13. Results and conclusion; Resultados e conclusoes

    NONE

    2009-10-15

    This chapter shows the results and conclusions of the ordered studies by the Science and Technology Ministry from Brazil to the Center of Management and Strategic Studies (CGEE), executed by a multidisciplinary team, most of UNICAMP - State University of Campinas, SP - for evaluation of Brazilian capacity and potential in the production of fuel bioethanol.

  14. 4.11 Summary and Conclusions

    Noßke, D.; Mattsson, S.; Johansson, L.

    This document is part of Subvolume A 'Fundamentals and Data in Radiobiology, Radiation Biophysics, Dosimetry and Medical Radiological Protection' of Volume 7 'Medical Radiological Physics' of Landolt-Börnstein - Group VIII 'Advanced Materials and Technologies'. It contains the Section '4.11 Summary and Conclusions' of the Chapter '4 Dosimetry in Nuclear Medicine Diagnosis and Therapy'.

  15. Data, model, conclusion, doing it again

    Molenaar, W.

    1998-01-01

    This paper explores the robustness of conclusions from a statistical model against variations in model choice (rather than variations in random sampling and random assignment to treatments, which are the usual variations covered by inferential statistics). After the problem formulation in section 1,

  16. Conclusions of the groups of experts

    The conclusions of the different groups of experts have been extracted from their full reports and are grouped in this paper: interdisciplinary communication techniques and tutorial programmes on rare events problems and their solution; statistics and decision theories applicable to rare events; reliability of mechanical components and structures; rare event data collection and analysis; common-mode failure analysis; human error analysis and quantification; Fessenheim automatic protective system assessment. General recommendations of the Groups of Experts concerning work still needed to develop to a sufficient degree techniques for treating rare events in reliability analyses of nuclear plants. A general discussion and conclusions are presented and final recommendations of the Task Force to CSNI are given

  17. Millian superiorities and the repugnant conclusion

    Jensen, Karsten Klint

    2008-01-01

    James Griffin has considered a form of superiority in value that is weaker than lexical priority as a possible remedy to the Repugnant Conclusion. In this article, I demonstrate that, in a context where value is additive, this weaker form collapses into the stronger form of superiority. And in a...... results for different interpretations of Griffin's suggestion regarding population ethics. None of them comes out very successful, but perhaps they nevertheless retain some interest....

  18. Eduquer par la musique

    Zhe, Ji

    2011-01-01

    La politique et l’éducation sont indissociables dans les tentatives de promouvoir le confucianisme en Chine contemporaine. L’union alors célébrée du sacré, du pouvoir et du savoir s’inscrit en tension avec une modernité d’abord caractérisée par la différenciation des institutions et des valeurs. Partant de ce constat, l’article étudie le cas particulier d’une société engagée depuis 2000 dans l’initiation des enfants à la musique classique et dans la promotion de la « culture de soi » chez les...

  19. Superiority in value and the repugnant conclusion

    Jensen, Karsten Klint

    2007-01-01

    James Griffin has considered a weak form of superiority in value a possible remedy to the Repugnant Conclusion. In this paper, I demonstrate that, in a context where value is additive, this weaker form collapses into a stronger form of superiority. And in a context where value is non-additive, weak...... superiority does not amount to a radical value difference at all. I then spell out the consequences of these results for different interpretations of Griffin's suggestion regarding population ethics. None of them comes out very successful, but perhaps they nevertheless retain some interest....

  20. Epistemology applied to conclusions of expert reports.

    Lucena-Molina, Jose-Juan

    2016-07-01

    It is believed that to build a robust reasoning logic to make probabilistic inferences in forensic science from a merely mathematical or logistical viewpoint is not enough. Mathematical logic is the positive science of reasoning and as for that it is only interested in the positive calculus of its validity, regardless any prior ontological assumption. But without a determined ontology and epistemology which imply to define the concepts that they will use, it seems difficult that the proposed scientifically correct mathematical solution be successful as a European standard for making conclusions in forensic reports because it has to be based on judicial language. Forensic experts and Courts are not interested in the development of a positive science but in a practical science: in clarifying whether certain known facts are related to a possible crime. Therefore, not only the coherence of the demonstrative logic reasoning used (logic of propositions) is important, but also the precision of the concepts used by language and consistency among them in reasoning (logic of concepts). There is a linguistic level essential for a successful communication between the forensic practitioner and the Court which is mainly related, in our opinion, to semantics and figures of speech. The first one is involved because words used in forensic conclusions often have different meanings - it is said that they are polysemic - and the second one because there is often metonymy as well. Besides, semantic differences among languages regarding words with the same etymological root add another difficulty for a better mutual understanding. The two main European judicial systems inherit a wide and deep culture related to evidence in criminal proceedings and each of them has coined their own terminology but there are other two more abstract levels such as logical and epistemological, where we can find solid arguments by which terms used at legal level on conclusions of forensic reports could be

  1. Key conclusions of the Svalbard Shoreline Experiment

    Major conclusions reached from the Svalbard Field Trials are discussed. In general, the field trials are considered to have been successful as meaningful differences in oil concentration between plots and treatments were quantitatively demonstrated and measured. Some of the major findings of the study are: (1) mechanical relocation of oil sediments significantly accelerated the rate of oil removal; (2) sediment relocation did not elevate toxicity in the near-shore environment to unacceptable levels; (3) changes in oil loading of surface sediments in the upper inter-tidal zone were not sufficient to support mixing (tilling) of the oiled layer as viable for operational use; (4) initial oil removal in this environment was relatively rapid; (5) biodegradation did occur in the Arctic environment and was stimulated by the addition of fertilizer; and (6( microscopic observation and image analysis confirmed that the formation of oil-mineral aggregates facilitated the removal of oil from the beaches

  2. Deriving, Communicating and Applying Safeguards Conclusions

    Safeguards are arrangements for verifying that states are in compliance with international agreements or undertakings relating to the peaceful use of nuclear materials. The IAEA has operated a system of comprehensive safeguards agreements with non-nuclearweapon states parties to the Treaty on the Non-Proliferation of Nuclear Weapons (NPT) for over forty years. This system has evolved over time in recognition that a progressively broader approach to verification is required to substantiate the IAEA's conclusions. Current policy debates on the further evolution of safeguards implementation primarily relate to the development of the IAEA's 'state level concept' for safeguards, and the resolution of compliance or performance issues in several countries. Safeguards experts acknowledge that the identification and clarification of principles for determining safeguards priorities and for deriving safeguards conclusions will be a crucial step in strengthening the non-proliferation regime. This paper recommends the development of a procedure by which the IAEA Secretariat would issue standardized notices to the Board of Governors in situations where anomalies in safeguards implementation remain unresolved for a prescribed period of time. These 'Automatic Notices' are designed to assist the Secretariat with the structured communication of technical information about state compliance. The procedure would enhance the transparency of the operation of the IAEA, the credibility of the verification assurance, and the timeliness of identification of potential non-compliance. It also provides states, whether acting through the Agency's Board of Governors or otherwise, with opportunities to craft effective solutions to potential proliferation crises. Furthermore, the existence and number of these 'Automatic Notices' would provide one transparent and objective basis for differentiating between states in future allocation of safeguards

  3. Expression of MMP-1/PAR-1 and patterns of invasion in oral squamous cell carcinoma as potential prognostic markers

    Fan HX

    2015-07-01

    Full Text Available Hai-Xia Fan,1 Yan Chen,1 Bo-Xiong Ni,1 Shan Wang,1 Miao Sun,2 Dong Chen,2 Jin-Hua Zheng11Department of Anatomy, Basic Medical Science College, 2Department of Oral and Maxillofacial Surgery, Stomatological Hospital, Harbin Medical University, Harbin, People’s Republic of ChinaBackground: Matrix metalloproteinase (MMP-1 degrades type I collagen of the extracellular matrix and also activates protease activated receptor (PAR-1 to induce angiogenesis. The aims of this study were to evaluate microvessel density (MVD and the expression of PAR-1 and MMP-1 in oral squamous cell carcinoma (SCC specimens with different patterns of invasion (POI and to evaluate their association with clinical outcomes.Methods: Seventy-four surgically obtained oral SCC samples were classified by POI according to hematoxylin-eosin staining. MVD and the localization and intensity of PAR-1 and MMP-1 expression were detected by immunohistochemistry.Results: Of the 74 oral SCC samples, 18, 5, 34, and 17 showed type I, II, III, and IV POI, respectively. MVD and expression levels of MMP-1 and PAR-1 differed between POI types I–II and POI types III–IV. Patients with low tumor expression of MMP-1 and PAR-1 and low MVD had a longer survival time than those with high tumor expression of MMP-1 and PAR-1. Moreover, the survival time of patients with POI types III–IV was shorter than that of patients with POI types I–II.Conclusion: POI combined with expression levels of MMP-1 and PAR-1 may be a valuable tool for assessing the clinical prognosis of patients with oral SCC.Keywords: oral squamous cell carcinoma, pattern of invasion, immunohistochemistry, clinical outcomes

  4. Elusloom lennukiga puhkusele / Inge Parring

    Parring, Inge

    2003-01-01

    Ilmunud ka: Delovõje Vedomosti 1. okt. lk. 13. Air Cargo Estonia/ACE Logisticsi müügijuht Inge Parring tutvustab elusloomade transpordivõimalusi. Vt. samas: Loomade transportimiseks vajalikud dokumendid

  5. Conclusion on the peer review of the pesticide risk assessment of the active substance sulfoxaflor

    European Food Safety Authority

    2014-01-01

    The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State Ireland and the co-rapporteur Member States Czech Republic, France and Poland for the pesticide active substance sulfoxaflor and the assessment of applications for maximum residue levels (MRLs) are reported. The context of the peer review was that required by Regulation (EC) No 1107/2009 of the European Par...

  6. Datation par thermoluminescence

    1976-01-01

    Full Text Available Depuis 1953, de nombreux chercheurs se sont intéressés à la datation par thermoluminescence de minéraux anciennement brûlés ou cuits. Dans ce travail, après avoir rappelé quelques principes physiques de la thermoluminescence, on présente cette méthode de datation en mettant l'accent sur le mécanisme thermoluminescent dans une poterie. Ainsi la dose d'irradiation reçue par le matériau étant proportionnelle au temps écoulé depuis le 'zéro archéologique', il est possible de déterminer 'la dose archéologique' et d'en déduire l'âge de l'échantillon après avoir calculé la dose d'irradiation annuelle. La réalisation pratique d'un tel ensemble de mesure est cependant très ardue. Dans un prochain article, E. A. Decamps et A. Roman montreront des résultats relatifs à la thermoluminescence d'échantillons de quartz naturels, purs et dopés et la mise au point d'une nouvelle méthode de datation. Desde 1953, muchos investigadores se han interesado en la datación por termoluminiscencia de minerales antiguamente quemados o cocidos. Dentro de este trabajo, luego de haber recordado algunos principios físicos de la termoluminiscencia, se presenta este método de datación poniendo mayor atención en el mecanismo termoluminescente en una vasija de metal o de barro. Siendo proporcional la dosis de irradiación recibida al tiempo transcurrido desde el 'cero arqueológico', es posible determinar 'la dosis arqueológica', y deducir la edad de la muestra luego de haber calculado la dosis de irradiación anual. La realización práctica de un trabajo de tal dimensión es sin embargo muy ardua. En un próximo artículo, E. A. Decamps y A. Román presentarán los resultados relativos a la termoluminiscencia de muestras de cuarzo naturales, puras y dopadas y la elaboración de un nuevo método de datación. Since 1953, a number of scientists have been concerned with the use of thermoluminescence for the dating of burned or fired minerals

  7. Par Pond vegetation status 1996

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995, and into the early spring and late summer of 1996. Communities similar to the pre-drawdown, Par Pond aquatic plant communities continue to become re-established. Emergent beds of maidencane, lotus, waterlily, watershield, and Pontederia are extensive and well developed. Measures of percent cover, width of beds, and estimates of area of coverage with satellite data indicate regrowth within two years of from 40 to 60% of levels prior to the draw down. Cattail occurrence continued to increase during the summer of 1996, especially in the former warm arm of Par Pond, but large beds common to Par Pond prior to the draw down still have not formed. Lotus has invaded and occupies many of the areas formerly dominated by cattail beds. To track the continued development of macrophytes in Par Pond, future surveys through the summer and early fall of 1997, along with the evaluation of satellite data to map the extent of the macrophyte beds of Par Pond, are planned

  8. Immunopathogenic Background of Pars Planitis.

    Przeździecka-Dołyk, Joanna; Węgrzyn, Agnieszka; Turno-Kręcicka, Anna; Misiuk-Hojło, Marta

    2016-04-01

    Pars planitis is defined as an intermediate uveitis of unknown background of systemic disease with characteristic formations such as vitreous snowballs, snowbanks and changes in peripheral retina. The incidence of pars planitis varies 2.4-15.4 % of the uveitis patients. The pathogenesis of the disease is to be determined in future. Clinical and histopathological findings suggest an autoimmune etiology, most likely as a reaction to endogenous antigen of unknown source, with T cells predominant in both vitreous and pars plana infiltrations. T cells subsets play an important role as a memory-effector peripheral cell. Snowbanks are formed as an effect of post inflammatory glial proliferation of fibrous astrocytes. There is also a genetic predisposition for pars planitis by human leukocyte antigen and several other genes. A coexistence of multiple sclerosis and optic neuritis has been described in numerous studies. Epiretinal membrane, cataract, cystoid macular edema, retinal detachment, retinal vasculitis, neovascularization, vitreous peripheral traction, peripheral hole formation, vitreous hemorrhage, disc edema are common complications observed in pars planitis. There is a need to expand the knowledge of the pathogenic and immunologic background of the pars planitis to create an accurate pharmacological treatment. PMID:26438050

  9. Paracrine Apoptotic Effect of p53 Mediated by Tumor Suppressor Par-4

    Ravshan Burikhanov

    2014-01-01

    Full Text Available The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apoptosis in p53-deficient cancer cells. This paracrine effect was mediated by p53-dependent secretion of the tumor suppressor Par-4. Accordingly, the activation of p53 in normal mice, but not p53−/− or Par-4−/− mice, caused systemic elevation of Par-4, which induced apoptosis of p53-deficient tumor cells. Mechanistically, p53 induced Par-4 secretion by suppressing the expression of its binding partner, UACA, which sequesters Par-4. Thus, normal cells can be empowered by p53 activation to induce Par-4 secretion for the inhibition of therapy-resistant tumors.

  10. suPAR: the molecular crystal ball

    Thunø, Maria; Macho, Betina; Eugen-Olsen, Jesper

    2009-01-01

    soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences...... inflammation and pathogenic processes. We focus on the molecular mechanisms of the suPAR fragments and the link to the inflammatory process,as this could lead to medical applications in infectious and pathological conditions....

  11. Consequences of the feed-in management for the marketing of electric power from renewable energies. Are limited generators financially shut-down according to paragraph 13 par. 4 EnWG; Folgen des Einspeisemanagements fuer die Vermarktung von Strom aus Erneuerbaren Energien. Werden zwangsweise abgeregelte Erzeuger nach paragraph 13 Abs. 4 EnWG bilanziell glattgestellt?

    Soetebier, Jan [Bundesnetzagentur, Bonn (Germany)

    2012-09-15

    With the expansion of renewable energies, the network capacities on windy and sunny days are becoming scarce. If the capacities are not sufficient in order to accommodate all the electricity, conventional power plants and subordinately plants for the power generation from renewable plants have to be closed. What are the consequences of a compulsory curtailment for the marketing of the electric power? This question basically raised for conventional power plants as well as supply remunerated and directly exploited renewable energy plants. From this perspective, the author of this contribution reports on the impact on the stock marketing of the supply remunerated electric power from renewable energy sources according to the balancing mechanism of the Renewable Energy Law.

  12. ParAB Partition Dynamics in Firmicutes: Nucleoid Bound ParA Captures and Tethers ParB-Plasmid Complexes

    Lioy, Virginia S.; Andrea Volante; Nora E Soberón; Rudi Lurz; Silvia Ayora; Alonso, Juan C.

    2015-01-01

    In Firmicutes, small homodimeric ParA-like (δ2) and ParB-like (ω2) proteins, in concert with cis-acting plasmid-borne parS and the host chromosome, secure stable plasmid inheritance in a growing bacterial population. This study shows that (ω:YFP)2 binding to parS facilitates plasmid clustering in the cytosol. (δ:GFP)2 requires ATP binding but not hydrolysis to localize onto the cell's nucleoid as a fluorescent cloud. The interaction of (δ:CFP)2 or δ2 bound to the nucleoid with (ω:YFP)2 foci f...

  13. Designing Tone Reservation PAR Reduction

    Johansson Albin

    2006-01-01

    Full Text Available Tone reservation peak-to-average (PAR ratio reduction is an established area when it comes to bringing down signal peaks in multicarrier (DMT or OFDM systems. When designing such a system, some questions often arise about PAR reduction. Is it worth the effort? How much can it give? How much does it give depending on the parameter choices? With this paper, we attempt to answer these questions without resolving to extensive simulations for every system and every parameter choice. From a specification of the allowed spectrum, for instance prescribed by a standard, including a PSD-mask and a number of tones, we analytically predict achievable PAR levels, and thus implicitly suggest parameter choices. We use the ADSL2 and ADSL2+ systems as design examples.

  14. Childhood Pars Planitis; Clinical Features and Outcomes

    Homayoon Nikkhah

    2011-01-01

    Full Text Available Purpose: To evaluate the demographic and clinical features of childhood pars planitis, and to determine the therapeutic and visual outcomes of the disease. Methods: Medical records of pediatric patients (less than 16 years of age at diagnosis with pars planitis and at least 6 months of follow-up who were referred to Labbafinejad Medical Center, Tehran, Iran over a 22 year period were reviewed. Results: Overall, 117 eyes of 61 patients including 51 (83.6% male subjects were included. Mean age at the time of diagnosis was 7.8΁3.2 (range, 3-16 years. Mean best corrected visual acuity (BCVA was 0.88΁0.76 logMAR at presentation which improved to 0.39΁0.51 logMAR at final visit (P<0.001. Endotheliitis was present in 23 (19.6% eyes and was significantly more prevalent in subjects younger than 9 years (P=0.025. Cataract formation (41.9% and cystoid macular edema (19.7% were the most prevalent complications. Univariate regression analysis showed that better baseline visual acuity (OR=0.38, 95%CI 0.21-0.70, P=0.002, age older than 5 years at disease onset (OR=0.36, 95%CI 0.14-0.9, P=0.029, absence of endotheliitis (OR=0.39, 95%CI 0.15-0.99, P=0.047 and female gender (OR=3.77, 95%CI 1.03-13.93, P=0.046 were significantly associated with final BCVA of 20/40 or better. Conclusion: Childhood pars planitis was much more common among male subjects. Endotheliitis may be a sign of inflammation spillover and is more prevalent in younger patients. Visual prognosis is favorable in most patients with appropriate treatment.

  15. Conclusion générale. Penser la démocratie différentielle

    Faure, Alain

    2012-01-01

    Lorsque l'on coordonne un chantier de recherche aussi vaste sur le plan empirique que mal balisé sur le plan conceptuel, la tentation est grande, au moment de la conclusion, d'opter pour la stratégie de l'inven- taire à la Prévert, avec le risque d'une certaine évanescence picturale (style sfumato) ou, au contraire, d'une additivité trop signifiante (le pointillisme des néo-impressionnistes par exemple). L'effet est connu chez les peintres: les compositions par empilement de petites touches p...

  16. Par Pond Fish, Water, and Sediment Chemistry

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond

  17. Première partie : conclusion

    Nguyen, Minh Hang

    2015-01-01

    D’intéressants points ont été développés dans cette comparaison, laquelle emporte la supériorité technique de la Convention de Vienne par rapport au droit vietnamien de la vente. Nous avons recommandé d’insérer certaines règles de droit uniforme dans le droit vietnamien afin d’apporter plus de précisions aux articles du Code civil vietnamien portant sur la formation du contrat. Telles sont par exemple les règles énoncées dans l’article 18-2 et 19-2 concernant respectivement la détermination d...

  18. CERCLA interim action at the Par Pond unit: A case study

    The Par Pond unit designated under CERCLA consists of sediments within a Savannah River Site (SRS) cooling water reservoir. The sediments are contaminated with radionuclides and nonradioactive constituents from nuclear production reactor operations. The mercury in Par Pond is believed to have originated from the Savannah River. Because of Par Pond Dam safety Issues, the water level of the reservoir was drawn down, exposing more than 1300 acres of contaminated sediments and triggering the need for CERCLA interim remedial action. This paper presents the interim action approach taken with Par Pond as a case study. The approach considered the complexity of the Par Pond ecosystem, the large size of Par Pond, the volume of contaminated sediments, and the institutional controls existing at SRS. The Environmental Protection Agency (EPA) considers units with large volumes of low-concentration wastes, as is the case with Par Pond, to be open-quotes special sites.close quotes Accordingly, EPA guidance establishes that the range of alternatives developed focus primarily on containment options and other remedial approaches that mitigate potential risks associated with the open-quotes special site.close quotes The remedial alternatives, according to EPA, are not to be prohibitively expensive or difficult to implement. This case study also is representative of the types of issues that will need to be addressed within the Department of Energy (DOE) complex as nuclear facilities are transitioned to inactive status and corrective/remedial actions are warranted

  19. Chapitre XIII. Célébrer l'accord

    Rivaud, David

    2015-01-01

    Enraciné sur des bases qui laissent apparaître de nouvelles possibilités fiscales, militaires et politiques, entretenu par un dialogue aux formes multiples, l'accord de gouvernement trouve dans la ville des résonances symboliques, festives et rituelles qui à travers toute une série d'actes publics, au quotidien presque, travaillent à en conserver la mémoire ou mieux encore à en élaborer des représentations mentales. Bourges, Poitiers comme Tours offrent, à ...

  20. Performance testing of passive autocatalytic recombiners (PARs)

    Passive autocatalytic recombiners (PARs) have been under consideration in the U.S. as a combustible gas control system in advanced light water reactor (ALWR) containments for design basis and severe accidents. PARs do not require a source of power. Instead they use palladium or platinum as a catalyst to recombine hydrogen and oxygen gases into water vapor upon contact with the catalyst. Energy from the recombination of hydrogen with oxygen is released at a relatively slow but continuous rate into the containment which prevents the pressure from becoming too high. The heat produced creates strong buoyancy effects which increases the influx of the surrounding gases to the recombiner. These natural convective flow currents promote mixing of combustible gases in the containment. PARs are self-starting and self-feeding under a very wide range of conditions. The recombination rate of the PAR system needs to be great enough to keep the concentration of hydrogen (or oxygen) below acceptable limits. There are several catalytic recombiner concepts under development worldwide. The USNRC is evaluating a specific design of a PAR which is in an advanced stage of engineering development and has been proposed for ALWR designs. Sandia National laboratories (SNL), under the sponsorship and the direction of the USNRC, is conducting an experimental program to evaluate the performance of PARs. The PAR will be tested at the SURTSEY facility at SNL. The test plan currently includes the following experiments: experiments will be conducted to define the startup characteristics of PARs (i.e., to define what is the lowest hydrogen concentration that the PAR starts recombining the hydrogen with oxygen); experiments will be used to define the hydrogen depletion rate of PARs as a function of hydrogen concentration; and experiments will be used to define the PAR performance in the presence of high concentrations of steam. (author)

  1. Atividades e participação de crianças com Paralisia Cerebral conforme a Classificação Internacional de Funcionalidade, Incapacidade e Saúde Actividades y participación de niños com Parálisis Cerebral según la Clasificación Internacional de Funcionalidad, Incapacidad y Salud Activities and participation of children with Cerebral Palsy according to the International Classification of Functioning, Disability, and Health

    Ismênia de Carvalho Brasileiro

    2009-08-01

    Full Text Available A paralisia cerebral compromete o desempenho funcional do indivíduo acometido. Entretanto, as alterações nas atividades e participação deste têm sido pouco discutidas na literatura. O objetivo da presente pesquisa foi descrever características de um grupo de crianças com paralisia cerebral de uma instituição de Fortaleza quanto à capacidade em executar tarefas e participar das atividades de vida diária por meio da Classificação Internacional de Funcionalidade, Incapacidade e Saúde. Ao todo 32 participantes foram avaliados. Os dados foram coletados e agrupados pelo programa Statistical Package of Social of Science. A utilização da CIF proporcionou uma descrição objetiva quanto à dimensão da limitação das crianças com paralisia cerebral estudadas e quanto ao impacto desta alteração na vida da criança.La parálisis cerebral afecta al desempeño funcional del individuo acometido. Sin embargo, las alteraciones en las actividades y participación de este han sido poco discutidas en la literatura. El objetivo de la presente investigación fue describir características de un grupo de niños con parálisis cerebral de una institución de Fortaleza en relación a la capacidad de ejecutar tareas y participar en actividades de la vida diaria, por medio de la Clasificación Internacional de Funcionalidad, Incapacidad y Salud. En total fueron evaluados 32 participantes. Los datos fueron colectados y agrupados por el programa Statistical Package of Social of Science. La utilización de la CIF proporcionó una descripción objetiva en relación a la dimensión de la limitación de los niños con parálisis cerebral estudiada y al impacto de esta alteración en la vida del niño.Cerebral palsy is among the most common motor disabilities in our midst that limits individuals from carrying out their normal daily routines. The adjacent alterations, characterization, and participation of the child in these activities is not appropriated

  2. Par Pond vegetation status Summer 1995 -- Summary

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995. Communities similar to the pre-drawdown, Par Pond aquatic plant communities are becoming re-established. Emergent beds of maidencane, lotus, waterlily, and watershield are extensive and well developed. Cattail occurrence continued to increase during the summer, but large beds common to Par Pond prior to the drawdown have not formed. Estimates from SPOT HRV, remote sensing satellite data indicated that as much as 120 hectares of emergent wetlands vegetation may have been present along the Par Pond shoreline by early October, 1995. To track the continued development of macrophytes in Par Pond, future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  3. Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR2) is involved in vascular function

    Bucci, M; Vellecco, V; Harrington, L; Brancaleone, V; Roviezzo, F; Mattace Raso, G; Ianaro, A; Lungarella, G; De Palma, R; Meli, R; Cirino, G

    2013-01-01

    Background and Purpose Proteinase-activated receptors (PARs) and toll-like receptors (TLRs) are involved in innate immune responses. The aim of this study was to evaluate the possible cross-talk between PAR2 and TLR4 in vessels in physiological condition and how it varies following stimulation of TLR4 by using in vivo and ex vivo models. Experimental Approach Thoracic aortas were harvested from both naïve and endotoxaemic rats for in vitro studies. Arterial blood pressure was monitored in anaesthetized rats in vivo. LPS was used as a TLR4 agonist while PAR2 activating peptide (AP) was used as a PAR2 agonist. Aortas harvested from TLR4–/– mice were also used to characterize the PAR2 response. Key Results PAR2, but not TLR4, expression was enhanced in aortas of endotoxaemic rats. PAR2AP-induced vasorelaxation was increased in aortic rings of LPS-treated rats. TLR4 inhibitors, curcumine and resveratrol, reduced PAR2AP-induced vasorelaxation and PAR2AP-induced hypotension in both naïve and endotoxaemic rats. Finally, in aortic rings from TLR4–/– mice, the expression of PAR2 was reduced and the PAR2AP-induced vasodilatation impaired compared with those from wild-type mice and both resveratrol and curcumine were ineffective. Conclusions and Implications Cross-talk between PAR2 and TLR4 contributes to vascular homeostasis. PMID:22957757

  4. SUSY Les Houches Accord 2

    Allanach, B.; Balazs, C.; Belanger, G.; Bernhardt, M.; Boudjema, F.; Choudhury, D.; Desch, K.; Ellwanger, U.; Gambino, P.; Godbole, R.; Goto, T.; Guasch, J.; Guchait, M.; Hahn, T.; Heinemeyer, S.; Hugonie, C.; Hurth, T.; Kraml, S.; Kreiss, S.; Lykken, J.; Moortgat, F.; /Cambridge U., DAMTP /Monash U. /Annecy, LAPTH /Bonn U. /Harish-Chandra Res. Inst. /Orsay, LPT /Turin U. /INFN, Turin /Bangalore, Indian Inst. Sci. /KEK, Tsukuba /Barcelona U. /Tata Inst. /Munich, Max Planck Inst. /Cantabria Inst. of Phys. /Montpellier U. /CERN /SLAC /Edinburgh U. /Fermilab /Zurich, ETH /Southampton U.

    2007-11-08

    The Supersymmetry Les Houches Accord (SLHA) provides a universal set of conventions for conveying spectral and decay information for supersymmetry analysis problems in high energy physics. Here, we propose extensions of the conventions of the first SLHA to include various generalizations: the minimal supersymmetric standard model with violation of CP, R-parity, and flavor, as well as the simplest next-to-minimal model.

  5. La zone de libre-échange nord-américain : trois stratégies pour un accord

    Kim Sébastien Pham; Marie-Ange Veganzones

    1993-01-01

    [fre] La zone de libre échange nord-américain : trois stratégies pour un accord L'Accord de libre échange nord-américain (ALENA) a été signé le 18 décembre 1992 par le Canada, les Etats-Unis et le Mexique. Il devrait entrer en vigueur le 1er janvier 1994, après ratification par les parlements nationaux. Les Etats-Unis, cherchant à donner un nouveau souffle à leur politique commerciale, ont eu un rôle moteur dans les négociations. Ils ont été appuyés par le Mexique, qui consolide par son adhés...

  6. Number of objectives and conclusions in dissertations and thesis

    Liebano Richard Eloin

    2005-01-01

    Full Text Available PURPOSE: To analyze the number of objectives and conclusions presented in dissertations and thesis defended at Federal University of São Paulo - Paulista School of Medicine (UNIFESP - EPM. METHODS: It was realized a search in the master degree dissertations and doctor degree thesis defended at Federal University of São Paulo - Paulista School of Medicine in the years 2002 and 2003 that were found available in the central library of this university. RESULTS: From 723 master dissertations analyzed, 62 (8,57% presented only one objective and one conclusion, 134 (18,53% presented one objective and more than one conclusion and 527 (72,89% had more than one objective and more than one conclusion. From 502 doctor thesis analyzed, 23 (4,58% presented only one objective and one conclusion, 123 (24,50% presented one objective and more than one conclusion and 376 (74,90% had more than one objective and more than one conclusion.. CONCLUSIONS: It wasn't found in researched literature the number of objectives and conclusions a scientific work must have. A highest number of thesis and dissertations presented more than one objective and more than one conclusion.

  7. Optimal conclusive teleportation of a d-dimensional unknown state

    Son, W.; Lee, Jinhyoung; Kim, M.S.; Park, Y. -J.

    2000-01-01

    We formulate a conclusive teleportation protocol for a system in d-dimensional Hilbert space utilizing the positive operator valued measurement at the sending station. The conclusive teleportation protocol ensures some perfect teleportation events when the channel is only partially entangled, at the expense of lowering the overall average fidelity. We find the change of the fidelity as optimizing the conclusive teleportation events and discuss how much information remains in the inconclusive ...

  8. Etude de pièces anciennes par analyse PIXE. Comparaison avec d'autres techniques

    Frontier, J.P.; Brissaud, I.; Gruel, K.; Rousset, M; Tarrats-Saugnac, A.

    1988-01-01

    Des pièces de monnaie anciennes de trois espèces différentes (gauloises, romaines, hammadites) ont été analysées par émission de rayons X induite par particules chargées (PIXE). Des études par microsonde électronique et activation par neutrons lents et rapides ont permis une comparaison des diverses techniques pour préciser les informations et compléter les résultats expérimentaux. Dans cet article nous présentons les conclusions d'intérêt archéologique qui peuvent être extraites de ces diffé...

  9. Identification of uPAR-positive chemoresistant cells in small cell lung cancer.

    Margarita Gutova

    Full Text Available BACKGROUND: The urokinase plasminogen activator (uPA and its receptor (uPAR/CD87 are major regulators of extracellular matrix degradation and are involved in cell migration and invasion under physiological and pathological conditions. The uPA/uPAR system has been of great interest in cancer research because it is involved in the development of most invasive cancer phenotypes and is a strong predictor of poor patient survival. However, little is known about the role of uPA/uPAR in small cell lung cancer (SCLC, the most aggressive type of lung cancer. We therefore determined whether uPA and uPAR are involved in generation of drug resistant SCLC cell phenotype. METHODS AND FINDINGS: We screened six human SCLC cell lines for surface markers for putative stem and cancer cells. We used fluorescence-activated cell sorting (FACS, fluorescence microscopy and clonogenic assays to demonstrate uPAR expression in a subpopulation of cells derived from primary and metastatic SCLC cell lines. Cytotoxic assays were used to determine the sensitivity of uPAR-positive and uPAR-negative cells to chemotherapeutic agents. The uPAR-positive cells in all SCLC lines demonstrated multi-drug resistance, high clonogenic activity and co-expression of CD44 and MDR1, putative cancer stem cell markers. CONCLUSIONS: These data suggest that uPAR-positive cells may define a functionally important population of cancer cells in SCLC, which are resistant to traditional chemotherapies, and could serve as critical targets for more effective therapeutic interventions in SCLC.

  10. Activity of recombinant trypsin isoforms on human proteinase-activated receptors (PAR): mesotrypsin cannot activate epithelial PAR-1, -2, but weakly activates brain PAR-1

    Grishina, Zoryana; Ostrowska, Ewa; Halangk, Walter; Sahin-Tóth, Miklós; Reiser, Georg

    2005-01-01

    Trypsin-like serine proteinases trigger signal transduction pathways through proteolytic cleavage of proteinase-activated receptors (PARs) in many tissues. Three members, PAR-1, PAR-2 and PAR-4, are trypsin substrates, as trypsinolytic cleavage of the extracellular N terminus produces receptor activation. Here, the ability of the three human pancreatic trypsin isoforms (cationic trypsin, anionic trypsin and mesotrypsin (trypsin IV)) as recombinant proteins was tested on PARs.Using fura 2 [Ca2...

  11. Diagnostic Ultrasound and Pars Plana Vitrectomy in Endophthalmitis

    Jingjing Huang; Zhenfang Wang; Lijuan Zou; Xiaofeng Lin; Yiwen Luo; Zhaohui Yuan

    2004-01-01

    Purpose: To compare the results by B-scan ultrasonography and findings in pars plana vitrectomy, and assess the diagnostic value of B-scan ultrasonography in endophthalmitis.Methods: Thirty eyes of 30 subjects diagnosed as endophthalmitis were selected, who undergone preoperative B-scan ultrasonography. The result of pars plana vitrectomy was recorded. The above two results were compared.Results: On the evaluation of vitreous and retinal states in the patients with endophthalmitis, the sensitivity of ultrasound was 90%~100%, and the specificity was 79%~100%.Poorer preoperative visual acuity was related with retinal detachment and retinal dissolution. The preoperative visual acuity in eyes with local vitreous opacity was better than with diffuse vitreous opacity.Conclusion: Comparison of the results of B-scan ultrasonography and the findings in pars plana vitrectomy showed B-scan ultrasonography is highly sensitive, specific, and is very helpful in the evaluation of endophthalmitis. B-scan ultrasonography can not only supply much information in the diagnosis of endophthalmitis but also inspect its trends and changes, which is helpful in the selection of treatment and planning the time of surgery.

  12. A method for estimating the diffuse attenuation coefficient (KdPAR)from paired temperature sensors

    Read, Jordan S.; Rose, Kevin C.; Winslow, Luke A.; Read, Emily Kara

    2015-01-01

    A new method for estimating the diffuse attenuation coefficient for photosynthetically active radiation (KdPAR) from paired temperature sensors was derived. We show that during cases where the attenuation of penetrating shortwave solar radiation is the dominant source of temperature changes, time series measurements of water temperatures at multiple depths (z1 and z2) are related to one another by a linear scaling factor (a). KdPAR can then be estimated by the simple equation KdPAR ln(a)/(z2/z1). A suggested workflow is presented that outlines procedures for calculating KdPAR according to this paired temperature sensor (PTS) method. This method is best suited for conditions when radiative temperature gains are large relative to physical noise. These conditions occur frequently on water bodies with low wind and/or high KdPARs but can be used for other types of lakes during time periods of low wind and/or where spatially redundant measurements of temperatures are available. The optimal vertical placement of temperature sensors according to a priori knowledge of KdPAR is also described. This information can be used to inform the design of future sensor deployments using the PTS method or for campaigns where characterizing sub-daily changes in temperatures is important. The PTS method provides a novel method to characterize light attenuation in aquatic ecosystems without expensive radiometric equipment or the user subjectivity inherent in Secchi depth measurements. This method also can enable the estimation of KdPAR at higher frequencies than many manual monitoring programs allow.

  13. Causal Conclusions that Flip Repeatedly and Their Justification

    Kelly, Kevin T

    2012-01-01

    Over the past two decades, several consis- tent procedures have been designed to infer causal conclusions from observational data. We prove that if the true causal network might be an arbitrary, linear Gaussian net- work or a discrete Bayes network, then every unambiguous causal conclusion produced by a consistent method from non-experimental data is subject to reversal as the sample size increases any finite number of times. That result, called the causal flipping theorem, ex- tends prior results to the effect that causal discovery cannot be reliable on a given sam- ple size. We argue that since repeated flipping of causal conclusions is unavoidable in principle for consistent methods, the best possible discovery methods are consistent methods that retract their earlier conclusions no more than necessary. A series of sim- ulations of various methods across a wide range of sample sizes illustrates concretely both the theorem and the principle of com- paring methods in terms of retractions.

  14. Should the person be punished? Defeating conclusions from legal conditionals

    Gazzo Castañeda, Lupita Estefania

    2016-01-01

    Defeasible reasoning is people’s ability to withdraw previously drawn conclusions in light of new evidence. Defeasible reasoning is therefore especially important in law, where exculpatory evidence can bring judges to conclude that an offence should not be punished after all. The aim of this thesis was thus to investigate how people withdraw conclusions from legal rules. In a series of experiments, legal rules were presented as legal conditionals (e.g., “If a person kills another human, than ...

  15. Radioecological implications of the Par Pond drawdown

    The drawdown of the Par Pond reservoir created dramatic alterations in this formerly stable lentic ecosystem. In addition, the radiation environment at Par Pond has changed significantly because of the exposure of Cesium 137-contaminated sediments and the appearance of new transport pathways to the terrestrial environment. In response to this situation, SREL was asked to study the radioecological implications of the reservoir drawdown. This report contains the objectives, methods, and results of the SREL study

  16. C9.A/14 steelwork joints de poutres par plaque frontale : assemblages par gousset

    2015-01-01

    Les Tables de résistances ultimes des assemblages boulonnés par plaque frontale et par gousset, complétées par une description des modèles de calcul et des exemples d’application, ont pour but de faciliter la tâche de l'ingénieur et du constructeur. Cette première partie C9.A/14 contient les chapitres suivants: - Joints de poutres par plaque frontale en acier S235 et S355 - Assemblages par gousset en acier S235 et S355 Les Tables contiennent des données relatives à la géométrie ainsi que les valeurs de calcul correspondantes des résistances ultimes des assemblages ; elles remplacent le chapitre « Assemblages par plaques frontales et boulons HR » des anciennes Tables C9.1 de 1983 / 2002. Le calcul de ces assemblages par plaque frontale est basé sur les hypothèses du modèle de la méthode des composants décrite dans la norme SN EN 1993-1-8. Les vérifications sont effectuées selon la norme SIA 263:2013. Les assemblages par gousset remplacent les assemblages par double cornière, (telle...

  17. Regulatory cross-talk in the double par locus of plasmid pB171

    Ringgaard, Simon; Ebersbach, Gitte; Borch, Jonas; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2007-01-01

    The double par locus of Escherichia coli virulence factor pB171 consists of two adjacent and oppositely oriented par loci of different types, called par1 and par2. par1 encodes an actin ATPase (ParM), and par2 encodes an oscillating, MinD-like ATPase (ParA). The par loci share a central cis...... partition and promoter repression complexes. Surprisingly, ParB repressed transcription of the noncognate par operon, indicating cross-talk and possibly epistasis between the two systems. The par promoters, P1 and P2, affected each other negatively. The DNA binding activities of ParR and ParB correlated...

  18. The European Food Consumption Validation Project: conclusions and recommendations

    de Boer, E. J.; Slimani, N.; van 't Veer, P.;

    2011-01-01

    Background/Objectives: To outline and discuss the main results and conclusions of the European Food Consumption Validation (EFCOVAL) Project. Subjects/Methods: The EFCOVAL Project was carried out within the EU Sixth Framework Program by researchers in 11 EU countries. The activities focused on (1...

  19. 20 CFR 901.48 - Proposed findings and conclusions.

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Proposed findings and conclusions. 901.48 Section 901.48 Employees' Benefits JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES REGULATIONS GOVERNING THE PERFORMANCE OF ACTUARIAL SERVICES UNDER THE EMPLOYEE RETIREMENT INCOME SECURITY ACT OF 1974 Suspension...

  20. Hypothesis, Prediction, and Conclusion: Using Nature of Science Terminology Correctly

    Eastwell, Peter

    2012-01-01

    This paper defines the terms "hypothesis," "prediction," and "conclusion" and shows how to use the terms correctly in scientific investigations in both the school and science education research contexts. The scientific method, or hypothetico-deductive (HD) approach, is described and it is argued that an understanding of the scientific method,…

  1. Structural analysis of the ParR/parC plasmid partition complex

    Møller-Jensen, Jakob; Ringgaard, Simon; Mercogliano, Christopher P;

    2007-01-01

    Accurate DNA partition at cell division is vital to all living organisms. In bacteria, this process can involve partition loci, which are found on both chromosomes and plasmids. The initial step in Escherichia coli plasmid R1 partition involves the formation of a partition complex between the DNA....... coli plasmid pB171. ParR forms a tight dimer resembling a large family of dimeric ribbon-helix-helix (RHH)2 site-specific DNA-binding proteins. Crystallographic and electron microscopic data further indicate that ParR dimers assemble into a helix structure with DNA-binding sites facing outward. Genetic...... and biochemical experiments support a structural arrangement in which the centromere-like parC DNA is wrapped around a ParR protein scaffold. This structure holds implications for how ParM polymerization drives active DNA transport during plasmid partition....

  2. The role of quality management in delivering safeguards conclusions

    Drawing safeguards conclusions regarding the absence of undeclared nuclear material and activities is intrinsically more challenging than verifying the non-diversion of declared nuclear material. Important new measures are available to the IAEA to help in this respect. However, the Secretariat can only have confidence in the soundness of its conclusions, and thus provide credible assurances of States' compliance with their safeguards obligations, if the necessary and sufficient processes and tools are in place, if the processes are carried out correctly and adequately monitored and if appropriate feedback loops are used. It is simply not possible to carry out quality control activities to verify the absence of undeclared nuclear material and activities. Part of the approach being taken by the Department of Safeguards to meet this challenge is to implement a Departmental quality management system (QMS) based on the ISO 9001:2000 standard. This paper describes the steps being taken by the Department to implement such a system. (author)

  3. EMU – Fiscal Challenges: Conclusions For the New EU Members.

    Slawomir Bukowski

    2005-01-01

    The aim of the paper is to evaluate fiscal challenges which are facing the Economic and Monetary Union countries after four years of monetary union functioning. Then, the author formulates conclusions for accession countries which are planning to become members of the Economic and Monetary Unions in the near future. The first part of the paper deals with the criteria of fiscal stabilization within EMU, their significance and links to economic growth. On the one hand, these criteria limit poss...

  4. Valuation using multiples. How do analysts reach their conclusions?

    Fernández, Pablo

    2002-01-01

    This paper focuses on equity valuation using multiples. Our basic conclusion is that multiples nearly always have broad dispersion, which is why valuations performed using multiples may be highly debatable. We review the 14 most popular multiples and deal with the problem of using multiples for valuation: their dispersion. 1,200 multiples from 175 companies illustrate the dispersion of multiples of European utilities, English utilities, European construction companies, hotel companies, teleco...

  5. Biogeochemistry of uranium mill wastes program overview and conclusions

    The major findings and conclusions are summarized for research on uranium mill tailings for the US Department of Energy and the US Nuclear Regulatory Commission. An overview of results and interpretations is presented for investigations of 222Rn emissions, revegetation of tailings and mine spoils, and trace element enrichment, mobility, and bioavailability. A brief discussion addresses the implications of these findings in relation to tailings disposal technology and proposed uranium recovery processes

  6. Harmonization and development of resources and tools for Italian natural language processing within the PARLI project

    Bosco, Cristina; Delmonte, Rodolfo; Moschitti, Alessandro; Simi, Maria

    2015-01-01

    The papers collected in this volume are selected as a sample of the progress in Natural Language Processing (NLP) performed within the Italian NLP community and especially attested by the PARLI project. PARLI (Portale per l’Accesso alle Risorse in Lingua Italiana) is a project partially funded by the Ministero Italiano per l’Università e la Ricerca (PRIN 2008) from 2008 to 2012 for monitoring and fostering the harmonic growth and coordination of the activities of Italian NLP. It was proposed by various teams of researchers working in Italian universities and research institutions. According to the spirit of the PARLI project, most of the resources and tools created within the project and here described are freely distributed and they did not terminate their life at the end of the project itself, hoping they could be a key factor in future development of computational linguistics.

  7. Review conclusions by Ernst and Canter regarding spinal manipulation refuted

    Evans Roni

    2006-08-01

    Full Text Available Abstract In the April 2006 issue of the Journal of Royal Society of Medicine, Ernst and Canter authored a review of the most recent systematic reviews on the effectiveness of spinal manipulation for any condition. The authors concluded that, except for back pain, spinal manipulation is not an effective intervention for any condition and, because of potential side effects, cannot be recommended for use at all in clinical practice. Based on a critical appraisal of their review, the authors of this commentary seriously challenge the conclusions by Ernst and Canter, who did not adhere to standard systematic review methodology, thus threatening the validity of their conclusions. There was no systematic assessment of the literature pertaining to the hazards of manipulation, including comparison to other therapies. Hence, their claim that the risks of manipulation outweigh the benefits, and thus spinal manipulation cannot be recommended as treatment for any condition, was not supported by the data analyzed. Their conclusions are misleading and not based on evidence that allow discrediting of a large body of professionals using spinal manipulation.

  8. Traitement des eaux par électrofloculation

    Cansado, Isabel

    1997-01-01

    Traitement des eaux par electrofloculation Les écosystèmes aquatiques sont très affectés par les eaux de rejet qui sont déversées dans les cours d’eau. La charge de ces eaux existe sous diverses formes: solutés, colloïdes ou particules. Il est important de traiter l’eau usée à de faibles coûts au lieu de la rejeter directement dans le milieu récepeteur. Dans le but d’améliorer les procédés physico-chimiques de déstabilisation des émulsions, nous étudions les traitements par électrocoagulat...

  9. A comparison study of corneal topographic changes following 20-, 23-, and 25-G pars plana vitrectomy

    Alexandre Achille Grandinetti

    2015-10-01

    Full Text Available ABSTRACTPurpose:To evaluate and compare corneal topographic changes following pars plana vitrectomy with the 23-gauge (G and 25-G transconjuntival sutureless vitrectomy system as well as the standard 20-G vitrectomy system.Methods:We prospectively evaluated corneal topographic changes in 45 eyes of 45 patients divided into three groups according to vitrectomy system used (20-, 23-, and 25-G. All patients underwent computer-assisted videokeratography using an EyeSys System 3000 topographer preoperatively and at one week, one month, and three months postoperatively.Results:In the 20-G vitrectomy group, we found statistically significant postoperative changes in corneal curvature parameters with an average steepening of 0.98 ± 0.18 D (P<0.001 and 0.93 ± 0.21 D (P<0.001 at one week and one month, respectively. No statistically significant difference was observed at the three-month follow-up visit. In the 23- and 25-G groups, no statistically significant changes in corneal curvature parameters were observed at any postoperative follow-up visit.Conclusion:Twenty-three-gauge and 25-gauge transconjunctival sutureless vitrectomy did not induce topographic corneal changes following surgery, whereas 20-G vitrectomy was found to induce transient topographic corneal changes that had returned to preoperative levels at three months postoperatively.

  10. Programmation par contraintes avec des fourmis

    Khichane, Madjid; Albert, Patrick; Solnon, Christine

    2008-01-01

    National audience On explore dans cet article les possibilités d'intégration de la métaheuristique d'optimisation par colonies de fourmis (ACO) dans un langage de programmation par contraintes (PPC). L'idée est d'utiliser un langage de PPC pour décrire le problème à résoudre, ainsi que pour propager et vérifier les contraintes, et d'utiliser ACO pour guider la recherche de solutions. On illustre notre approche sur le problème d'ordonnancement de voitures.

  11. It pays to be green. A premature conclusion?

    It has been claimed that good environmental performance can improve firms' economic performance. However, because of e.g. data limitations, the methods applied in most previous quantitative empirical studies on effects of environmental performance on economic performance of firms suffer from several shortcomings. We discuss these shortcomings and conclude that previously applied methods are unsatisfactory as support for a conclusion that it pays for firms to be green. Then we illustrate the consequences of these shortcomings by performing several regression analyses of the effect of environmental performance on economic performance using a panel data set of Norwegian plants. A pooled regression where observable firm characteristics like e.g. size or industry are controlled for, confirms a positive effect of environmental performance on economic performance. However, the estimated positive effect could be due to omitted unobserved variables like management or technology. When the regression model controls for unobserved plant heterogeneity, the effect is generally no longer statistically significant. Hence, although greener plants tend to perform economically better, the analysis provides little support for the claim that it is because they are greener. These empirical findings further indicate that a conclusion that it pays to be green is premature

  12. RUSSIAN-PRUSSIAN NEUTRAL AGREEMENT IN DECEMBER, 1812: REASONS AND CIRCUMSTANCES OF THE CONCLUSION

    ZHUCHKOV K.B.

    2015-01-01

    The article critical reviewed the traditional historiography of Clausewitz's concept on which York voluntarily defected to the Russian army and established the true causes outcome Prussian troops from Napoleon's army. According to the author, the main reasons for the conclusion Russian-Prussian neutral convention in December 1812 became the victories of the Russian army during the war in 1812 and heavy retreat of Macdonald’s corps, which consisted of the Prussian troops.

  13. Increased plasma soluble uPAR level is a risk marker of respiratory cancer in initially cancer-free individuals

    Langkilde, Anne A; Ladelund, Steen; Andersen, Ove;

    2011-01-01

    BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a stable plasma biomarker associated with inflammation and disease. This study tested the association between suPAR levels and incident respiratory, gastrointestinal or other types of cancer in initially cancer-free individuals...... from a general population-based prospective study.METHODS: Baseline plasma samples, baseline characteristics, and follow-up data were available from 2656 individuals from the population-based Danish MONICA10 study, followed for a median of 12.6 years. Cancer was diagnosed according to ICD-8 and ICD-10...... codes and suPAR levels were measured using a commercially available ELISA. The association of suPAR levels with incident cancer during follow-up was analyzed using Cox regression, adjusted for established risk factors and the inflammatory markers C-reactive protein (CRP) and leukocyte numbers...

  14. Conclusion of the I.C.T. benchmark exercise

    The ICT Benchmark exercise made within the RIV working group of ESARDA on reprocessing data supplied by COGEMA for 53 routines reprocessing input batches made of 110 irradiated fuel assemblies from KWO Nuclear Power Plant was finally evaluated. The conclusions are: all seven different ICT methods applied verified the operator data on plutonium within about one percent; anomalies intentionally introduced to the operator data were detected in 90% of the cases; the nature of the introduced anomalies, which were unknown to the participants, was completely resolved for the safeguards relevant cases; the false alarm rate was in a few percent range. The ICT Benchmark results shows that this technique is capable of detecting and resolving anomalies in the reprocessing input data to the order of a percent

  15. Different partial volume correction methods lead to different conclusions

    Greve, Douglas N; Salat, David H; Bowen, Spencer L;

    2016-01-01

    A cross-sectional group study of the effects of aging on brain metabolism as measured with (18)F-FDG-PET was performed using several different partial volume correction (PVC) methods: no correction (NoPVC), Meltzer (MZ), Müller-Gärtner (MG), and the symmetric geometric transfer matrix (SGTM) using...... 99 subjects aged 65-87years from the Harvard Aging Brain study. Sensitivity to parameter selection was tested for MZ and MG. The various methods and parameter settings resulted in an extremely wide range of conclusions as to the effects of age on metabolism, from almost no changes to virtually all...... correlated with age. MG and SGTM were found to be similar; however, MG was sensitive to a thresholding parameter that can result in data loss. CSF uptake was surprisingly high at about 15% of that in gray matter. The exclusion of CSF from SGTM and MG models, which is almost universally done, caused...

  16. Workshop on large molten pool heat transfer summary and conclusions

    The CSNI Workshop on Large Molten Heat Transfer held at Grenoble (France) in March 1994 was organised by CSNI's Principal Working Group on the Confinement of Accidental Radioactive Releases (PWG4) with the cooperation of the Principal Working Group on Coolant System Behaviour (FWG2) and in collaboration with the Grenoble Nuclear Research Centre of the French Commissariat a l'Energie Atomique (CEA). Conclusions and recommendations are given for each of the five sessions of the workshops: Feasibility of in-vessel core debris cooling through external cooling of the vessel; Experiments on molten pool heat transfer; Calculational efforts on molten pool convection; Heat transfer to the surrounding water - experimental techniques; Future experiments and ex-vessel studies (open forum discussion)

  17. Conclusive quantum steering with superconducting transition edge sensors

    Smith, Devin H; de Almeida, Marcelo; Branciard, Cyril; Fedrizzi, Alessandro; Weinhold, Till J; Lita, Adriana; Calkins, Brice; Gerrits, Thomas; Nam, Sae Woo; White, Andrew G

    2011-01-01

    Quantum steering allows two parties to verify shared entanglement even if one measurement device is untrusted. A conclusive demonstration of steering through the violation of a steering inequality is of considerable fundamental interest and opens up applications in quantum communication. To date all experimental tests with single photon states have relied on post-selection, allowing untrusted devices to cheat by hiding unfavorable events in losses. Here we close this "detection loophole" by combining a highly efficient source of entangled photon pairs with superconducting transition edge sensors. We achieve an unprecedented $\\sim$62% conditional detection efficiency of entangled photons and violate a steering inequality with the minimal number of measurement settings by 48 standard deviations. Our results provide a clear path to practical applications of steering and to a photonic loophole-free Bell test.

  18. ParA and ParB coordinate chromosome segregation with cell elongation and division during Streptomyces sporulation.

    Donczew, Magdalena; Mackiewicz, Paweł; Wróbel, Agnieszka; Flärdh, Klas; Zakrzewska-Czerwińska, Jolanta; Jakimowicz, Dagmara

    2016-04-01

    In unicellular bacteria, the ParA and ParB proteins segregate chromosomes and coordinate this process with cell division and chromosome replication. During sporulation of mycelial Streptomyces, ParA and ParB uniformly distribute multiple chromosomes along the filamentous sporogenic hyphal compartment, which then differentiates into a chain of unigenomic spores. However, chromosome segregation must be coordinated with cell elongation and multiple divisions. Here, we addressed the question of whether ParA and ParB are involved in the synchronization of cell-cycle processes during sporulation in Streptomyces To answer this question, we used time-lapse microscopy, which allows the monitoring of growth and division of single sporogenic hyphae. We showed that sporogenic hyphae stop extending at the time of ParA accumulation and Z-ring formation. We demonstrated that both ParA and ParB affect the rate of hyphal extension. Additionally, we showed that ParA promotes the formation of massive nucleoprotein complexes by ParB. We also showed that FtsZ ring assembly is affected by the ParB protein and/or unsegregated DNA. Our results indicate the existence of a checkpoint between the extension and septation of sporogenic hyphae that involves the ParA and ParB proteins. PMID:27248800

  19. Transcription factor network downstream of protease activated receptors (PARs modulating mouse bladder inflammation

    Hurst Robert E

    2007-08-01

    Full Text Available Abstract Background All four PARs are present in the urinary bladder, and their expression is altered during inflammation. In order to search for therapeutic targets other than the receptors themselves, we set forth to determine TFs downstream of PAR activation in the C57BL/6 urinary bladders. Methods For this purpose, we used a protein/DNA combo array containing 345 different TF consensus sequences. Next, the TF selected was validated by EMSA and IHC. As mast cells seem to play a fundamental role in bladder inflammation, we determined whether c-kit receptor deficient (Kitw/Kitw-v mice have an abrogated response to PAR stimulation. Finally, TFEB antibody was used for CHIP/Q-PCR assay and revealed up-regulation of genes known to be downstream of TFEB. Results TFEB, a member of the MiTF family of basic helix-loop-helix leucine zipper, was the only TF commonly up-regulated by all PAR-APs. IHC results confirm a correlation between inflammation and TFEB expression in C57BL/6 mice. In contrast, Kitw/Kitw-v mice did not exhibit inflammation in response to PAR activation. EMSA results confirmed the increased TFEB binding activity in C57BL/6 but not in Kitw/Kitw-v mice. Conclusion This is the first report describing the increased expression of TFEB in bladder inflammation in response to PAR activation. As TFEB belongs to a family of TFs essential for mast cell survival, our findings suggest that this molecule may influence the participation of mast cells in PAR-mediated inflammation and that targeting TFEB/MiTF activity may be a novel approach for the treatment of bladder inflammatory disorders.

  20. Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR.

    Katia Cortese

    Full Text Available BACKGROUND: The urokinase receptor (uPAR/CD87 is highly expressed in malignant tumours. uPAR, as a GPI anchored protein, is preferentially located at the cell surface, where it interacts with its ligands urokinase (uPA and the extracellular matrix protein vitronectin, thus promoting plasmin generation, cell-matrix interactions and intracellular signalling events. Interaction with a complex formed by uPA and its inhibitor PAI-1 induces cell surface down regulation and recycling of the receptor via the clathrin-coated pathway, a process dependent on the association to LRP-1. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we have found that along with the ligand-induced down-regulation, uPAR also internalizes and recycles constitutively through a second pathway that is independent of LRP-1 and clathrin but shares some properties with macropinocytosis. The ligand-independent route is amiloride-sensitive, does not require uPAR partitioning into lipid rafts, is independent of the activity of small GTPases RhoA, Rac1 and Cdc42, and does not require PI3K activity. Constitutively endocytosed uPAR is found in EEA1 positive early/recycling endosomes but does not reach lysosomes in the absence of ligands. Electron microscopy analysis reveals the presence of uPAR in ruffling domains at the cell surface, in macropinosome-like vesicles and in endosomal compartments. CONCLUSIONS/SIGNIFICANCE: These results indicate that, in addition to the ligand-induced endocytosis of uPAR, efficient surface expression and membrane trafficking might also be driven by an uncommon macropinocytic mechanism coupled with rapid recycling to the cell surface.

  1. Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation.

    Zhao, Baoyu; Gandhi, Sonu; Yuan, Cai; Luo, Zhipu; Li, Rui; Gårdsvoll, Henrik; de Lorenzi, Valentina; Sidenius, Nicolai; Huang, Mingdong; Ploug, Michael

    2015-03-27

    The urokinase-type plasminogen activator receptor (uPAR) is a multidomain glycolipid-anchored membrane protein, which facilitates extracellular matrix remodeling by focalizing plasminogen activation to cell surfaces via its high-affinity interaction with uPA. The modular assembly of its three LU (Ly6/uPAR-like) domains is inherently flexible and binding of uPA drives uPAR into its closed conformation, which presents the higher-affinity state for vitronectin thus providing an allosteric regulatory mechanism. Using a new class of epitope-mapped anti-uPAR monoclonal antibodies (mAbs), we now demonstrate that the reciprocal stabilization is indeed also possible. By surface plasmon resonance studies, we show that these mAbs and vitronectin have overlapping binding sites on uPAR and that they share Arg91 as hotspot residue in their binding interfaces. The crystal structure solved for one of these uPAR·mAb complexes at 3.0Å clearly shows that this mAb preselects the closed uPAR conformation with an empty but correctly assembled large hydrophobic binding cavity for uPA. Accordingly, these mAbs inhibit the uPAR-dependent lamellipodia formation and migration on vitronectin-coated matrices irrespective of the conformational status of uPAR and its occupancy with uPA. This is the first study to the best of our knowledge, showing that the dynamic assembly of the three LU domains in uPARwt can be driven toward the closed form by an external ligand, which is not engaging the hydrophobic uPA binding cavity. As this binding interface is also exploited by the somatomedin B domain of vitronectin, therefore, this relationship should be taken into consideration when exploring uPAR-dependent cell adhesion and migration in vitronectin-rich environments. PMID:25659907

  2. The role of quality management in delivering safeguards conclusions

    Full text: How does an organisation assess and assure the quality of its product when that product is a statement regarding the absence of undeclared activities? Such a statement cannot be quality controlled in a traditional sense like manufactured components, there is simply nothing to measure or control against, and unlike a modern service industry the customer is not able to simply switch to another service provider if it perceives that the product is of poor quality, however it may define quality. This is the challenge that the IAEA faces as more States move towards safeguards under a comprehensive safeguards agreement and an additional protocol, with the requirement to draw conclusions not only on the correctness of declarations but also their completeness. Conclusions are no longer based solely on assessment against well defined Criteria for facility types but instead have a wide variety of inputs, ranging from expanded declarations, results of complementary access, assessment of environmental samples, open source information, satellite imagery, analysis of trade networks in addition to the output from inspections. These all combine to generate an overall State evaluation. When considering the far-reaching consequences of getting it wrong, more than hope is needed to assure the international community that conclusions drawn by the Agency are sound and credible. Part of the approach being taken by the Department of Safeguards to meet this challenge is to implement a quality management system (QMS) based on ISO9001:2000. Implementing a QMS will enable the Secretariat to confirm that the necessary and sufficient processes are in place, they are carried out correctly, adequately monitored and that appropriate feedback loops are used. Importantly it will also allow the Department to understand what the processes cannot deliver so that any weaknesses can be handled correctly. The need for a QMS was recognised internally by the Department of Safeguards in light of

  3. SWANN ORGANIQUE (EN PASSANT PAR BECKETT PANOPTIQUE

    Sjef Houppermans

    2013-12-01

    Full Text Available Comme quoi Swann a bel et bien un corps souffrant et jouissant. Comme quoi Swann absorbe le monde surtout par ses six sens. Comme quoi l´univers de Swann est une aire de dissémination que Samuel Beckett sonde exemplairement dans son étude de 1930.

  4. IMPROVEMENT OF PRODUCTION PLANNING IN COMPANY PARS KOMPONENTY

    René Klega

    2014-03-01

    Full Text Available The article analyzes the current status of production planning in company Pars Komponenty s.r.o., proposes a new method of planning based on application of the principle of MRP. It is a discrete type of production with high complexity of BOM and MTO (Make-to-Order and ETO (Engineering-to-Order from the point of decoupling point. The original planning system plans according to production capacity backward without collisions, but for a given type of production does not work in practice. Planning system was analyzed and the main problems were identified, which were high work in progress and material stocks. This article target is to propose a new planining system based on the inclusion of time reserves of purchased material items. New planning system was tested in practise with benefit in reducing both the material inventory and work in progress.

  5. Le succès par l’image ?

    Chermette, Myriam

    2008-01-01

    Fig. 1. Paris-Soir, 3 septembre 1933, n°3620, page 1 (détail), coll. ACRPP. L’image fait-elle vendre ? La question n’est pas neuve, a été maintes fois posée et la réponse par l’affirmative paraît aujourd’hui évidente si l’on s’en tient au flux d’images que nous avons quotidiennement sous les yeux. Le monde de la presse, particulièrement, lui accorde une légitimité incontestée, les nouvelles formules laissant davantage de place à l’iconographie. Cettesituation n’est pas le résultat d’un long c...

  6. CRP and suPAR are differently related to anthropometry and subclinical organ damage

    Lyngbæk, Stig; Sehestedt, Thomas; Marott, Jacob L; Hansen, Tine W; Olsen, Michael H; Andersen, Ove; Linneberg, Allan; Madsbad, Sten; Haugaard, Steen B; Eugen-Olsen, Jesper; Jeppesen, Jørgen

    2013-01-01

    BACKGROUND: Low-grade inflammation is a marker for cardiovascular disease (CVD). The inflammatory biomarkers C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR) independently predict CVD. We tested the hypothesis that these biomarkers reflect different aspects of...... the inflammation associated with CVD. METHODS: We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body...... mass index (BMI) (P3: 1.31 (1.16-1.47), whereas log-CRP was not (1.00 (0.89-1.11))). CONCLUSIONS: CRP is positively associated with anthropometric measures, whereas suPAR is linked to endothelial dysfunction and atherosclerosis....

  7. Bionics in Engineering Education Considerations, Experiences and Conclusions

    Ralf Neurohr

    2008-01-01

    Full Text Available During recent years bionics, a new discipline which is in charge with the transfer of the principles of construction, regulation, interaction and organisation of biology into innovative technical solutions, has attracted significant interest from various industries. Based on this request for bionic expertise in engineering, the faculty for teaching engineering in foreign languages (FILS at ‘Politehnica’ University of Bucharest started a course in bionics in SS 2007, which was supported by the expertise of the German ‘Bionik-Kompetenz-Netz’, one of the leading organizations in bionics. This is the report on the considerations involved in the course concept, the first experiences with the students' acceptance, some conclusions and future perspectives for extending bionics activities at ‘Politehnica’. Finally, within the last section, the evaluation of a questionnaire, filled in by the students at the end of the course, will be presented. In order to avoid any confusion, considering overlapping or mixing up with other bio-disciplines related to technology, the paper starts with a short introduction, explaining the principles of bionics and providing a clear definition of the field.

  8. Summary of the discussion, Conclusion of the meeting

    The discussion was organised in three major periods corresponding to the main themes developed by the programme of the meeting: the qualification approaches, the qualification experience accumulated so far, one particular frame or motivation of the ISI qualification: the risk based (or informed) ISI. The qualification approaches presented by national representatives raised few questions. More discussion was induced on the qualification concepts, responsibilities, need and writing of the technical justification, motivation for the open trials, similitude between concepts, benefit deriving from the qualification of inspection procedures and further motivation. the conclusion could be as the following: the evolution of qualification applications, even if issued from harmonised concepts, appears to be nationalistically based. It is a thought that emulation and harmonisation could actually produce both savings and improvements in this area. 'The wheel does not have to be re-invented in each country' and it is the declared objective of ENIQ. There seems to be a need for some international agreement in the setting of standards for qualification. One area which seems to continue to be of underlying concern is in the characterisation of defects. There seems to be a need for appropriate 'defected blocks' satisfying the criteria of representativeness, quality, low cost, reproducibility, etc. More specific cases of Technical Justification development are needed to serve as examples and incentive for the case of this element of inspection qualification

  9. Acceleration toward the conclusion negotiation of bilateral nuclear cooperation agreements indispensable for globalization

    According to Japan's basic policies of new growth strategy, it would be one option of the economic growth to increase exports of nuclear power plant system or its equipments. However, bilateral nuclear cooperation agreements are indispensable for business activities on nuclear power. Recently signature of agreement with Jordan, agreed conclusion negotiation with Vietnam and Korea, under negotiation with India and expected negotiation with Indonesia and Malaysia. Signed agreements with Russia and Kazakhstan will be coming into effect and contribute nuclear fuel supply at export of nuclear power system. This special article consists of four expert's papers titled as (1) necessity of conclusion negotiation of nuclear cooperation agreements with several countries simultaneously and in parallel, (2) Japan's nuclear cooperation in new era, (3) desirable acceleration of conclusion negotiation of nuclear cooperation agreements and (4) insurance of nuclear fuel supply fundamental for global business activities of Japan's nuclear industries-best choice to establish cooperative relations with US and Russia. (T. Tanaka)

  10. Medical irradiation of children. Beware of too fast conclusion

    The publication in january 2004 in the British medical journal of the article of P. Hall and coll. 'Effect of low doses of ionizing irradiation in infancy on cognitive function in adulthood: Swedish population based cohort study, has been noticed by the Radiation protection group of the French speaking society of pediatrics imaging. The authors evaluate the psycho-motor development of less eighteen months years old children and irradiated between 1930 and 1959 for a face angioma. They study for each dose of irradiation ( from 0 to 250 m Gy) the level of school attendance and their results to the psycho-motor tests made during conscription medical examination. They noticed a diminution of 50% of the access success rate to university for the children having received an irradiation dose of 250 mG. No effect is noticed under the irradiation dose of 100 mGy. In their conclusions the authors compare these irradiation doses to these ones delivered in brain scanner examination. These results seem overestimated compared with the work made on fetuses ( publication 84 of ICRP) then the fetus is considered as more sensitive to ionizing radiations than the infant. The dose of 120 mGy is found in the literature and now the dose delivered in pediatrics are in the area of 0 and 100 mGy where no effect has been revealed in the cohort of irradiated children. The article does not include the principle of justification that is used nowadays and the replacement by the trans fontanel echography has allowed to reduce the number of brain scanner, used only for limited cases where the benefit is superior the the risk of irradiation. (N.C.)

  11. The Danish energy crop research and development project - main conclusions

    Production of energy crops in Denmark is more or less non-existent in Denmark at the time being. However, the need for biomass on the other side of year 2005 exceeds the existing biomass resources and a substantial amount of energy crops will be necessary in order to fulfil the goals in Energy 21. The targeted share of the use of renewable energy sources by year 2030 is approximately 30%. Energy crops are seen as the most important new resource in order to create a balanced input mix of renewable in the energy system. The energy crops are mainly seen as fuel in small and medium sized CHP plants and in the big power plants. The Danish energy crop project consists of three main parts: a demonstration part, a research and development part, and an overall assessment part. Based on the results from the project the following overall conclusions can be made: Seen from a strictly market and production economic point of view energy crops will not be competitive in a foreseeable future, neither as a production for farmers nor as a fuel at the utility companies; The costs per GJ of energy crops are still higher than a GJ of straw; The cost difference between annual and perennial energy crops are slightly in favour of perennials, however the conditions on the individual farms should govern the choice between annual and perennial energy crops; Energy crops must be seen as part of an overall environmental scheme covering both agriculture and the energy sector; Given the right production scheme energy crops can be grown on environmental sensitive areas and on most ground water protection areas; Adding the potential sustainability benefits like reduced nutrient leakage and reduced CO2 emissions energy crops seem to be a sensible and sustainable solution; Due to different handling, storage and fuel characteristics an all year delivery scheme of energy crops should include a mix of different energy crops to keep overall cost down. (BA)

  12. Waste Handling Shaft concrete liner degradation conclusions and recommendations

    The primary function of the Waste Handling Shaft (WHS) at the Waste Isolation Pilot Plant (WIPP) is to permit the transfer of radioactive waste from the surface waste handling building to the underground storage area. It also serves as an intake shaft for small volumes of air during normal storage operations and as an emergency escape route. Part of the construction was the placement of a concrete liner and steel reinforced key in 1984. During a routine shaft inspection in May 1990, some degradation of the WHS concrete liner was observed between the depths of 800 and 900 feet below the ground surface. Detailed investigations of the liner had been carried out by Sandia National Laboratories and by Westinghouse Electric Corporation Waste Isolation Division (WID) through Lankard Materials Laboratory. Observations, reports, and data support the conclusion that the concrete degradation, resulting from attack by chemically aggressive brine, is a localized phenomena. It is the opinion of the WID that the degradation is not considered an immediate or near term concern; this is supported by technical experts. WID recommendations have been made which, when implemented, will ensure an extended liner life. Based on the current assessment of available data and the proposed shaft liner monitoring program described in this report, it is reasonable to assume that the operational life of the concrete shaft liner can safely support the 25-year life of the WIPP. Analysis of data indicates that degradation of the shaft's concrete liner is attributed to chemically aggressive brine seeping through construction joints and shrinkage cracks from behind the liner in and around the 834-foot depth. Chemical and mechanical components of concrete degradation have been identified. Chemical attack is comprised of several stages of concrete alteration. The other component, mechanical degradation, results from the expansive forces of crystals forming in the concrete pore space

  13. The bussola study. Final results, conclusions and proposals

    Antonio Luiz da Silva Brasileiro

    2000-09-01

    Full Text Available OBJECTIVE: To evaluate the use of thrombolytic and acetylsalicylic acid therapies in acute myocardial infarct patients as well as the availability of technical and human resources for the care of these patients in the emergency units of the city of Rio de Janeiro. Additional objectives were the evaluation of the use of primary angioplasty and the level of acceptance of SBC /RJ as an entity responsible for programs of continued medical education. METHODS: Interviews with physicians at 46 emergency units in the city of Rio de Janeiro. RESULTS: Of the 46 emergency units inspected, a policy of encouragement to use thrombolytic therapy was only prescribed in 6.5%. In 1/3 of the public wards no thrombolytic agents were available, and in none of them was access to primary angioplasty regularly available; 45.9% did not offer the minimal conditions required for the handling of cases of acute myocardial infarction; 60% of the physicians on-call (at both public and private emergency units, appeared not to know the importance of the use of acetylsalicylic acid in acute myocardial infarct patients; all physicians interviewed would participate in programs of continued medical education organized by the SBC/RJ. CONCLUSION: The study suggests there was: 1 the low probability of the use of thrombolytic therapy in the majority of the emergency units in of the city of Rio de Janeiro due to the inadequate policy of waiting for the transfer of the patient to coronary or intensive care unit; 2 a low awareness to the importance of early use of acetylsalic acid in acute myocardial infarct; 3 half of the emergency units of the public net do not have the minimal conditions required for the handling of cases of acute myocardial infarction; 4 a high level of credibility exists that would enable the SBC/RJ to set up programs for continued medical education to change the mentality regarding the use of thrombolytic therapy and of acetylsalicylic acid.

  14. A Combined Global and Local Approach to Elucidate Spatial Organization of the Mycobacterial ParB-parS Partition

    Combining diverse sets of data at global (size, shape) and local (residue) scales is an emerging trend for elucidating the organization and function of the cellular assemblies. We used such a strategy, combining data from X-ray and neutron scattering with H/D-contrast variation and X-ray footprinting with mass spectrometry, to elucidate the spatial organization of the ParB-parS assembly from Mycobacterium tuberculosis. The ParB-parS participates in plasmid and chromosome segregation and condensation in predivisional bacterial cells. ParB polymerizes around the parS centromere(s) to form a higher-order assembly that serves to recruit cyto-skeletal ParA ATPases and SMC proteins for chromosome segregation. A hybrid model of the ParB-parS was built by combining and correlating computational models with experiment-derived information about size, shape, position of the symmetry axis within the shape, internal topology, DNA-protein interface, exposed surface patches, and prior knowledge. This first view of the ParB-parS leads us to propose how ParB spread on the chromosome to form a larger assembly.

  15. A Combined Global and Local Approach to Elucidate Spatial Organization of the Mycobacterial ParB-parS Partition Assembly

    B Chaudhuri; S Gupta; V Urban; M Chance; R DMello; L Smith; K Lyons; J Gee

    2011-12-31

    Combining diverse sets of data at global (size, shape) and local (residue) scales is an emerging trend for elucidating the organization and function of the cellular assemblies. We used such a strategy, combining data from X-ray and neutron scattering with H/D-contrast variation and X-ray footprinting with mass spectrometry, to elucidate the spatial organization of the ParB-parS assembly from Mycobacterium tuberculosis. The ParB-parS participates in plasmid and chromosome segregation and condensation in predivisional bacterial cells. ParB polymerizes around the parS centromere(s) to form a higher-order assembly that serves to recruit cyto-skeletal ParA ATPases and SMC proteins for chromosome segregation. A hybrid model of the ParB-parS was built by combining and correlating computational models with experiment-derived information about size, shape, position of the symmetry axis within the shape, internal topology, DNA-protein interface, exposed surface patches, and prior knowledge. This first view of the ParB-parS leads us to propose how ParB spread on the chromosome to form a larger assembly.

  16. A Combined Global and Local Approach to Elucidate Spatial Organization of the Mycobacterial ParB-parS Partition

    Chaudhuri, Barnali [University of Buffalo, The State University of New York; Gupta, Sayan [Case Western Reserve University; Urban, Volker S [ORNL; Chance, Mark [Case Western Reserve University; D' Mello, Rhijuta [Case Western Reserve University; Smith, Lauren [University of Buffalo, The State University of New York; Lyons, Kelly [University of Buffalo, The State University of New York; Gee, Jessica [University of Buffalo, The State University of New York

    2010-01-01

    Combining diverse sets of data at global (size, shape) and local (residue) scales is an emerging trend for elucidating the organization and function of the cellular assemblies. We used such a strategy, combining data from X-ray and neutron scattering with H/D-contrast variation and X-ray footprinting with mass spectrometry, to elucidate the spatial organization of the ParB-parS assembly from Mycobacterium tuberculosis. The ParB-parS participates in plasmid and chromosome segregation and condensation in predivisional bacterial cells. ParB polymerizes around the parS centromere(s) to form a higher-order assembly that serves to recruit cyto-skeletal ParA ATPases and SMC proteins for chromosome segregation. A hybrid model of the ParB-parS was built by combining and correlating computational models with experiment-derived information about size, shape, position of the symmetry axis within the shape, internal topology, DNA-protein interface, exposed surface patches, and prior knowledge. This first view of the ParB-parS leads us to propose how ParB spread on the chromosome to form a larger assembly.

  17. Four cases of endophthalmitis after 25-gauge pars plana vitrectomy

    Mutoh T

    2012-08-01

    Full Text Available Tetsuya Mutoh, Koji Kadoya, Makoto ChikudaDepartment of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, JapanAbstract: We report our recent experience with four cases of endophthalmitis (one male, three females after 25-gauge pars plana vitrectomy (PPV. One was a case of persistent cystoid macular edema caused by branch retinal vein occlusion, whereas the remaining three were cases of epiretinal membrane. Preoperative antibiotics before the first PPV procedure were not administered in three of the four cases. Endophthalmitis occurred 2–4 days after the first procedure in all cases, for which ceftazidime 2.0 mg/0.1 mL and vancomycin 1.0 mg/0.1 mL were injected into the vitreous cavity. This was followed by emergent 20-gauge PPV and intraocular lens removal using an infusion fluid containing ceftazidime and vancomycin. After the second PPV procedure, progress was good in three cases while retinal detachment occurred in the remaining case one month after surgery; this case required a third PPV procedure. Final best-corrected visual acuity ranged from 20/100 to 20/25 for the four cases. Bacterial cultures were negative after the second PPV procedure in all cases. In conclusion, postoperative endophthalmitis occurred in four of 502 cases (0.80% that underwent 25-gauge PPV at our hospital. It is important to minimize the incidence of endophthalmitis after 25-gauge PPV.Keywords: 25-gauge pars plana vitrectomy, endophthalmitis, incidence

  18. Relationship between ParE gene mutation and fluoroquinolones resistance in Mycoplasma hominis%人型支原体ParE基因突变与耐氟喹诺酮类药物的关系

    罗永慧; 段颖卿; 甘雪华; 王旭菲; 舒向荣

    2014-01-01

    目的:探讨人型支原体对氟喹诺酮类药物的耐药机制。方法自临床分离的8株耐氟喹诺酮类药物的人型支原体(Mh),对其ParE基因PCR扩增后进行测序分析,与基因库中的野生型菌株MHPG21基因序列比对,分析ParE基因突变位点与菌株耐氟喹诺酮类药物的关系。结果与野生株MHPG21对比,6株检出ParE基因所编码的氨基酸残基发生D 426→N变异。结论 Mh临床分离株对氟喹诺酮类药物的耐药可能与ParE基因所编码的氨基酸残基D 426→N变异有关。%Objective To explore the fluoroquinolones resistance meachanisms of Mycoplasma hominis (Mh). Methods A total of 8 strains of Mh with different fluoroquinolones resistance phenotype were analyzed, the ParE gene was amplified and sequenced. The sequencing results of ParE gene were compared with that in the wild type strain PG21, then analyzed the relation between ParE gene mutation and fluoroquinolones resistance. Results Compared with wild strain PG21, ParE gene in 6 strains got a D426→N mutation. Conclusion The fluoroquinolones resistance of Mh might be associate with ParE gene D426→N mutation.

  19. SARNET hydrogen deflagration benchmarks: Main outcomes and conclusions

    ratios of 0, 0.33 and 0.6 were considered to generate different levels of turbulence. The second benchmark objective was the investigation of the diluting effect on flame propagation. Thus, three tests performed in the ENACCEF facility using the same blockage ratio of 0.63 and three different initial gas compositions (with 10, 20 and 30 vol.% diluents) have been considered. Since ENACCEF runs at ambient temperature, a surrogate to steam was used consisting of a mixture of 0.6He + 0.4CO2 on molar basis. This paper aims to present the benchmarks conclusions regarding the ability of LP and CFD combustion models to predict the effect of turbulence and diluent on flame propagation

  20. Implementation of severe accident management measures - Summary and conclusions

    implemented in various ways in many plants, but not yet in all plants. A systematic approach, which is based upon a clearly defined decision-making process, is one of the features implemented in many cases. Available means are determined and priorities are set. This approach is made up of strategies intended to become an optimum approach to prevent or mitigate the consequences of beyond-design basis accidents. It is based upon a prepared information package about plant-specific behaviour to be expected in beyond design scenarios. The approaches followed in the different countries do not fit one single pattern. Harmonization, to the extent it is desirable, does not seem feasible at this stage. As a rule, the responsibility of the plant owner for the safety of his plant remains untouched. Also, safety goals may vary between countries. This report presents the general conclusion and recommendations of the workshop and the summaries of the sessions

  1. OECD/SERENA Project Report. Summary and Conclusions

    involving nominally 20 kilograms of prototypic melt. The analytical programme was aimed at complementing the analytical work in WGAMA/SERENA activity, completed in 2006, by integrating the results of the experimental programme in the current phase, and by updating the capabilities of the FCI models/codes for use in reactor safety analysis. The scope of the reactor application exercise was to verify whether progress made in the SERENA programme in understanding and modelling key FCI phenomena for reactor applications (mainly phenomena related to premixing, e.g., jet fragmentation, voiding, melt solidification, etc., as well as the role of melt properties) contributed to a reduction of scatter in code predictions for ex-vessel FCI, observed in the WGAMA/SERENA activity. A better consistency of the results was noted between various FCI codes although some discrepancies still exist on the absolute values. The scatter in most 2-D simulations is more due to the ultimate choice of the parameters (e.g., fragmentation criteria in the explosion phase) than to fundamental differences in the physics. This discrepancy will reduce further when the codes will have improved models based on the new experimental data produced in the project. Note the current experimental data have not been fully capitalised yet; accordingly, it will take some time to improve the models. The OECD/SERENA project accomplished in large part its stated objectives. The project generated new experimental data for development of new phenomenological models closed to real reactor case conditions (corium composition), improvement of existing models, and assessment of FCI codes. The project also provided new insights; however, it would be sometime before the insights can be fully integrated into new and improved models and codes. It should be noted that the FCI models and codes can only be as precise as the experimental data and that there are inherent uncertainties in experimental data. While from a regulatory and

  2. CSNI/NEA Rasplav seminar 2000. Summary and conclusions

    various boundary conditions were investigated. The work involved a combination of integral and separate effect tests including molten-salt tests to investigate non-eutectic mixtures and the effects of stratification, extension of the material property database to allow interpretation and modelling of the experimental data. The CSNI decided to hold a seminar where the major outcome of the RASPLAV Project could be presented and discussed also in the context of other experienced activities on Severe Accidents. The objectives of the seminar are: - to review the experimental results of the RASPLAV Project; - to exchange information on complementary research; - to discuss the progress made on understanding severe accident progression; - to discuss the applicability to nuclear power plants and use of the results. The Seminar was intended to provide an in-depth review of the RASPLAV Project in terms of the technical capabilities, results and analyses produced during the project execution. The application of the results and their significance for power plant applications were addressed. Relevant results of the complementary research carried out at various laboratories were also presented. The seminar consisted of five sessions organised as follows: - Opening and overview; - Experimental results; - Theoretical Analyses; - Application and complementary research; - Conclusion

  3. Comparative analysis of a plant pseudoautosomal region (PAR in Silene latifolia with the corresponding S. vulgaris autosome

    Blavet Nicolas

    2012-06-01

    Full Text Available Abstract Background The sex chromosomes of Silene latifolia are heteromorphic as in mammals, with females being homogametic (XX and males heterogametic (XY. While recombination occurs along the entire X chromosome in females, recombination between the X and Y chromosomes in males is restricted to the pseudoautosomal region (PAR. In the few mammals so far studied, PARs are often characterized by elevated recombination and mutation rates and high GC content compared with the rest of the genome. However, PARs have not been studied in plants until now. In this paper we report the construction of a BAC library for S. latifolia and the first analysis of a > 100 kb fragment of a S. latifolia PAR that we compare to the homologous autosomal region in the closely related gynodioecious species S. vulgaris. Results Six new sex-linked genes were identified in the S. latifolia PAR, together with numerous transposable elements. The same genes were found on the S. vulgaris autosomal segment, with no enlargement of the predicted coding sequences in S. latifolia. Intergenic regions were on average 1.6 times longer in S. latifolia than in S. vulgaris, mainly as a consequence of the insertion of transposable elements. The GC content did not differ significantly between the PAR region in S. latifolia and the corresponding autosomal region in S. vulgaris. Conclusions Our results demonstrate the usefulness of the BAC library developed here for the analysis of plant sex chromosomes and indicate that the PAR in the evolutionarily young S. latifolia sex chromosomes has diverged from the corresponding autosomal region in the gynodioecious S. vulgaris mainly with respect to the insertion of transposable elements. Gene order between the PAR and autosomal region investigated is conserved, and the PAR does not have the high GC content observed in evolutionarily much older mammalian sex chromosomes.

  4. A comparison study of corneal topographic changes following 20-, 23-, and 25-G pars plana vitrectomy

    Alexandre Achille Grandinetti; Vinicius Kniggendorf; Luciane Bugmann Moreira; Carlos Augusto Moreira Junior; Ana Tereza Ramos Moreira

    2015-01-01

    ABSTRACTPurpose:To evaluate and compare corneal topographic changes following pars plana vitrectomy with the 23-gauge (G) and 25-G transconjuntival sutureless vitrectomy system as well as the standard 20-G vitrectomy system.Methods:We prospectively evaluated corneal topographic changes in 45 eyes of 45 patients divided into three groups according to vitrectomy system used (20-, 23-, and 25-G). All patients underwent computer-assisted videokeratography using an EyeSys System 3000 topographer p...

  5. Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

    Grégory Baronian

    Full Text Available Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ΔparB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis.

  6. Debris impact on emergency coolant recirculation - summary and conclusions

    to two orders of magnitude because of strainer clogging. Consequently, the CSNI decided to continue its previous efforts in the area. The overall purpose of the 2004 Workshop was to discuss the impact of new information made available since 1996 and to promote consensus among member countries on identification of remaining technical issues important to safety, and on possible paths for their resolution. The specific purposes of the Workshop were: a. To review the knowledge base and in particular information developed after 1999, and to consider the validity of the conclusions drawn. b. To exchange information on the current status of research related to debris generation, debris transportation, and sump strainer clogging and penetration phenomena, in particular for PWRs, and to assess uncertainties. c. To exchange and disseminate information on recent and current activities and practices in these areas. d. To identify and discuss differences between approaches relevant to reactor safety. e. To identify technical issues and programs of interest for international collaborative research and develop an Action Plan outlining activities that CSNI should undertake in the area of strainer or sump screen clogging during the next few years. Summary of the main findings: a. The safety significance of the sump strainer clogging depends on the plant design (e.g. sump strainer, ECCS) and backfitting measures performed. b. The following are examples of PWR design features that could influence the debris impact on the ECCS sump performance: - Type of insulation (material, combination of materials, protection). - Break size to be postulated. - Transport in containment with or without containment spray system (CSS). - Degree of turbulence and flow velocities in the sump influenced by CSS, water level, break flow location and sump geometry. - Redundancy of sumps and residual heat removal system (RHRS). - Strainer design (area, mesh size). - Positioning of recirculation pumps and vortex

  7. Regulatory cross-talk in the double par locus of plasmid pB171

    Ringgaard, Simon; Ebersbach, Gitte; Borch, Jonas;

    2007-01-01

    The double par locus of Escherichia coli virulence factor pB171 consists of two adjacent and oppositely oriented par loci of different types, called par1 and par2. par1 encodes an actin ATPase (ParM), and par2 encodes an oscillating, MinD-like ATPase (ParA). The par loci share a central cis-actin...... well with the observed transcriptional regulation of the par operons in vivo and in vitro. Integration host factor (IHF) was identified as a novel factor involved in par2-mediated plasmid partitioning....

  8. Les Brulures Chimiques Par Le Laurier Rose

    Bakkali, H.; Ababou, M.; Nassim Sabah, T.; Moussaoui, A.; Ennouhi, A.; Fouadi, F.Z.; Siah, S.; Ihrai, H.

    2010-01-01

    Le laurier rose ou Nerium oleander est un arbuste qui pousse naturellement dans les régions méditerranéennes. Au Maroc on le trouve dans les lieux humides. Il est réputé par ses risques de toxicité systémique en cas d'empoisonnement à cause de la présence de deux alcaloïdes, surtout l'oléandrine. La littérature illustre des cas d'utilisation locale des feuilles de cette plante contre la gale, les hémorroïdes et les furoncles. Nous rapportons deux cas de brûlures chimiques par le laurier rose ...

  9. Annotation sémantique par classification

    Toussaint, Yannick; Tenier, Sylvain

    2007-01-01

    Les systèmes actuels d'annotation sémantique exploitent peu les connaissances du domaine et fonctionnent essentiellement du texte vers l'ontologie. Pourtant, il est fréquent qu'un élément dans une page doive être annoté par un concept parce que certains autres éléments de cette même page sont annotés par d'autres concepts. Cet article propose une méthode d'annotation prenant en compte cette dépendance entre concepts, exprimée dans une ontologie sous forme de concepts définis. L'utilisation de...

  10. Recombination in the Human Pseudoautosomal Region PAR1

    Anjali G Hinch; Nicolas Altemose; Nudrat Noor; Peter Donnelly; Simon R Myers

    2014-01-01

    The pseudoautosomal region (PAR) is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this o...

  11. Par Pond refill water quality sampling

    This study was designed to document anoxia and its cause in the event that the anoxia caused a fish kill. However, no fish kill was observed during this study, and dissolved oxygen and nutrient concentrations generally remained within the range expected for southeastern reservoirs. Par Pond water quality monitoring will continue during the second summer after refill as the aquatic macrophytes become reestablished and nutrients in the sediments are released to the water column

  12. Combined DSEK and Transconjunctival Pars Plana Vitrectomy

    Mona Sane

    2016-01-01

    Full Text Available We report here three patients who underwent combined Descemet’s stripping with endothelial keratoplasty and transconjunctival pars plana vitrectomy for bullous keratopathy and posterior segment pathology. A surgical technique and case histories are described. Anatomic and visual outcomes of combined Descemet’s stripping with endothelial keratoplasty and vitrectomy were excellent. Our experience provides technical guidelines and limitations. The combined minimally invasive techniques allow for rapid anatomical recovery and return of function and visual acuity in a single sitting.

  13. Taare Zameen Par and dyslexic savants

    Chakravarty, Ambar

    2009-01-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were pr...

  14. STRATEGIES (MARKETING DECISIONS ADAPTATION AND CONCLUSIONS OF TRANSNATIONAL NEW BRANDS ON THE RUSSIAN MARKET SOFT DRINKS

    Diana Olegovna YAMPOLSKAYA

    2014-01-01

    Full Text Available For several years the Russian market of soft drinks is growing rapidly. According to experts, this trend will continue in the future, but because our country is attrac-tive for brands large multinational companies. This article describes various ways to enter the Russian market brands world's largest companies, studied the experi-ence of promotion beverage company Coca-Cola, The peculiarities of the Russian perception of brands, shows how they are reflected in the advertising campaigns of the leading players in the market, formulate conclusions regarding behaviors of TNCs in various conditions.

  15. Studying the Possibility of Conclusion of Time Proportional Contracts via Definite Contracts

    Seyed Mohammad Sadegh Tabatabaei

    2013-01-01

    Full Text Available Time proportional contracts are such contracts in which the ownership of the property or itsprofits is transferred to the contracting party, proportional to time. This means that the partywill have the right to use or operate the property in determined portion of the year and will beable to intervene in the property permanently or alternately according to the terms of thecontract. This kind of contracts could be formed as a contract of rent, partnership in either theproperty or its profits, common sale conditional to partnership in profits, and the contract ofcompromise. Concerning the essence of such contracts, conclusion in the form of loan,exchange, and the right to benefit is impossible. Hereby, we will try to examine thepossibility of conclusion of time proportional contracts in the form of determined contracts.

  16. Serum uPAR as Biomarker in Breast Cancer Recurrence: A Mathematical Model

    Hao, Wenrui; Friedman, Avner

    2016-01-01

    There are currently over 2.5 million breast cancer survivors in the United States and, according to the American Cancer Society, 10 to 20 percent of these women will develop recurrent breast cancer. Early detection of recurrence can avoid unnecessary radical treatment. However, self-examination or mammography screening may not discover a recurring cancer if the number of surviving cancer cells is small, while biopsy is too invasive and cannot be frequently repeated. It is therefore important to identify non-invasive biomarkers that can detect early recurrence. The present paper develops a mathematical model of cancer recurrence. The model, based on a system of partial differential equations, focuses on tissue biomarkers that include the plasminogen system. Among them, only uPAR is known to have significant correlation to its concentration in serum and could therefore be a good candidate for serum biomarker. The model includes uPAR and other associated cytokines and cells. It is assumed that the residual cancer cells that survived primary cancer therapy are concentrated in the same location within a region with a very small diameter. Model simulations establish a quantitative relation between the diameter of the growing cancer and the total uPAR mass in the cancer. This relation is used to identify uPAR as a potential serum biomarker for breast cancer recurrence. PMID:27078836

  17. Serum uPAR as Biomarker in Breast Cancer Recurrence: A Mathematical Model.

    Hao, Wenrui; Friedman, Avner

    2016-01-01

    There are currently over 2.5 million breast cancer survivors in the United States and, according to the American Cancer Society, 10 to 20 percent of these women will develop recurrent breast cancer. Early detection of recurrence can avoid unnecessary radical treatment. However, self-examination or mammography screening may not discover a recurring cancer if the number of surviving cancer cells is small, while biopsy is too invasive and cannot be frequently repeated. It is therefore important to identify non-invasive biomarkers that can detect early recurrence. The present paper develops a mathematical model of cancer recurrence. The model, based on a system of partial differential equations, focuses on tissue biomarkers that include the plasminogen system. Among them, only uPAR is known to have significant correlation to its concentration in serum and could therefore be a good candidate for serum biomarker. The model includes uPAR and other associated cytokines and cells. It is assumed that the residual cancer cells that survived primary cancer therapy are concentrated in the same location within a region with a very small diameter. Model simulations establish a quantitative relation between the diameter of the growing cancer and the total uPAR mass in the cancer. This relation is used to identify uPAR as a potential serum biomarker for breast cancer recurrence. PMID:27078836

  18. Plasma suPAR levels are associated with mortality, admission time, and Charlson Comorbidity Index in the acutely admitted medical patient

    Haupt, Thomas Huneck; Petersen, Janne; Ellekilde, Gertrude;

    2012-01-01

    months after inclusion by their unique civil registry number and using Danish registries to determine admission times, readmissions, International Classification of Diseases, 10th Edition (ICD-10) diagnoses, and mortality. Statistical analysis was used to determine suPAR's association...... adjusting for age, sex, C-reactive protein (CRP), and Charlson Score. Furthermore, among the various Charlson Score disease groups, suPAR was significantly higher in those with diabetes, cancer, cardiovascular disease, and liver disease compared to those without comorbidities. CONCLUSIONS: SuPAR is a marker......, and it is speculated that suPAR is a low-grade inflammation marker reflecting on disease severity. The aim of this prospective observational study was to determine if the plasma concentration of suPAR is associated with admission time, re-admission, disease severity/Charlson Comorbidity Index Score, and mortality...

  19. Características morfológicas da pars de C2 de humanos Características morfológicas de la pars de C2 de humanos Morphologic characteristics of C2 humans pars

    Charles André Carazzo

    2009-09-01

    lados izquierdo y derecho. La largura promedio del pedículo fue de 10.5 mm y la medida promedio encontrada para la largura eje-pedículo fue de 24.9 mm, además del ancho del pedículo que fue de 2.8 mm. El ángulo sagital encontrado fue de 19.6° y de la horizontal de 28.5°. CONCLUSIÓN: este estudio demuestra la viabilidad para la colocación de tornillos en la pars de C2 en una población caucásica, pero destacándose la gran variabilidad anatómica encontrada en las medidas referentes.OBJECTIVE: to evaluate de morphometry of the pars of the second cervical vertebra, assess the variations existent and predict its safety for the placement of screws through a posterior cervical approach. METHODS: 58 vertebrae were obtained for anatomic study (116 pars of C2 and measured the height and width of the pars, besides the length of the axis-pedicle, width and length of the pedicle, sagittal and medial angulations. All measurements were separated as to their right and left sides, completed the calculation of media, variation, standard deviation and compared to previous studies. RESULTS: the medium width of the pars of C2 was 9,5 mm, the height, 9,5 mm, without significant difference between right and left sides. The medium length of the pedicle was 10.5 mm and the medium measurement found for the length axis-pedicle was of 24.9 mm and the width of the pedicle was of 2.8 mm. The sagittal angulation found was of 19.6º and the horizontal was of 28.5º. CONCLUSIONS: this study demonstrates the viability of positioning screws in the pars of C2 in a Caucasian population, emphasizing, however, the great anatomic variability found in the referred measurements.

  20. HIV-1 infected lymphoid organs upregulate expression and release of the cleaved form of uPAR that modulates chemotaxis and virus expression.

    Manuela Nebuloni

    Full Text Available Cell-associated receptor for urokinase plasminogen activator (uPAR is released as both full-length soluble uPAR (suPAR and cleaved (c-suPAR form that maintain ability to bind to integrins and other receptors, thus triggering and modulating cell signaling responses. Concerning HIV-1 infection, plasma levels of suPAR have been correlated with the severity of disease, levels of immune activation and ineffective immune recovery also in individuals receiving combination anti-retroviral therapy (cART. However, it is unknown whether and which suPAR forms might contribute to HIV-1 induced pathogenesis and to the related state of immune activation. In this regard, lymphoid organs represent an import site of chronic immune activation and virus persistence even in individuals receiving cART. Lymphoid organs of HIV-1(+ individuals showed an enhanced number of follicular dendritic cells, macrophages and endothelial cells expressing the cell-associated uPAR in comparison to those of uninfected individuals. In order to investigate the potential role of suPAR forms in HIV-1 infection of secondary lymphoid organs, tonsil histocultures were established from HIV-1 seronegative individuals and infected ex vivo with CCR5- and CXCR4-dependent HIV-1 strains. The levels of suPAR and c-suPAR were significantly increased in HIV-infected tonsil histocultures supernatants in comparison to autologous uninfected histocultures. Supernatants from infected and uninfected cultures before and after immunodepletion of suPAR forms were incubated with the chronically infected promonocytic U1 cell line characterized by a state of proviral latency in unstimulated conditions. In the contest of HIV-conditioned supernatants we established that c-suPAR, but not suPAR, inhibited chemotaxis and induced virus expression in U1 cells. In conclusion, lymphoid organs are an important site of production and release of both suPAR and c-suPAR, this latter form being endowed with the capacity of

  1. Evaluation of the PAR corneal topography system

    Jindal, Prateek; Cheung, Susan; Pirouzian, Amir; Keates, Richard H.; Ren, Qiushi

    1995-05-01

    The purpose of this study was to evaluate the raster photogrammetry based Corneal Topography System by determining: inter-operator variability, reproducibility of images, effects of defocused and decentered images, and the precision of data at different optical zones. 4 human cadaver eyes were used to study the inter-operator variability. To study the reproducibility of images, 3 human cadaver eyes and a test surface doped with flourescine (provided by PAR Vision Systems Corporation) were focused and their images taken four successive times. Defocused and decentered images were taken of 4 human cadaver eyes and four times of the test surface mentioned above. The precision of defocused/decentered cadaver eyes was evaluated at the following optical zones: 3 mm, 4 mm, 5 mm, and 6 mm. All human cadaver eyes used in the above experiments had their epithelial layer removed before imaging. Average inter-operator variability was 0.06 D. In reproducibility attempts, there was an average deviation of 0.28 D for the human cadaver eyes and 0.04 D for the test surface. The defocused and decentered test surface gave an average deviation of 0.09 D. Defocused and decentered cadaver eyes resulted in an average deviation of 0.52 D, 0.37 D, 0.24 D, and 0.22 D at optical zones of 3 mm, 4 mm, 5 mm, and 6 mm, respectively. The imaging method employed by PAR Vision Systems Corporation virtually eliminates inter-operator variability. The PAR Corneal Topography System's clinical usefulness, however, could be improved by improving the reproducibility of images, decreasing the sensitivity to spatial alignment, and increasing accuracy over smaller optical zones.

  2. Clinical outcomes of pars plicata anterior vitrectomy: 2-year results

    Priya Narang

    2015-01-01

    Full Text Available Purpose: To demonstrate the safety and outcome of a surgical approach that uses pars plicata site for anterior vitrectomy during phacoemulsification procedure complicated by posterior capsule rupture and residual cortical matter. Design: Single center, retrospective, interventional, noncomparative study. Materials and Methods: Medical records of a consecutive series of 35 eyes of 35 patients who underwent pars plicata anterior vitrectomy (PPAV were reviewed. The main outcome measures were corrected and uncorrected distance visual acuity (CDVA, UDVA, early and late postoperative complications and intraocular pressure (IOP. Ultrasound biomicroscopic (UBM evaluation of sclerotomy site and spectral domain optical coherence tomography analysis for central macular thickness (CMT was performed. The final visual outcome at 2 years was evaluated. Results: At 2 years follow-up, the mean postoperative UDVA (logarithm of the minimum angle of resolution [logMAR] and CDVA (logMAR was 0.49 ± 0.26 and 0.19 ± 0.14, respectively. There was no significant change in the IOP (P = 0.061 and the mean CMT at 2 years was 192.5 ± 5.54 mm. The postoperative UBM image of the sclerotomy site at 8 weeks demonstrated a clear wound without any vitreous adhesion or incarceration. Intraoperative hyphema was seen in 1 (2.8% case and postoperative uveitis was seen in 2 (5.7% cases, which resolved with medications. No case of an iatrogenic retinal break or retinal detachment was reported. Conclusions: PPAV enables a closed chamber approach, allows thorough cleanup of vitreous in the pupillary plane and anterior chamber and affords better access to the subincisional and retropupillary cortical remnant with a significant visual outcome and an acceptable complication rate.

  3. Radiological findings and healing patterns of incomplete stress fractures of the pars interarticularis

    The objective was to retrospectively record the CT and MRI features and healing patterns of acute, incomplete stress fractures of the pars interarticularis. The CT scans of 156 adolescents referred with suspected pars interarticularis stress fractures were reviewed. Patients with incomplete (grade 2) pars fractures were included in the study. Fractures were assessed on CT according to vertebral level, location of cortical involvement and direction of fracture propagation. MRI was also performed in 72 of the 156 cases. MRI images of incomplete fractures were assessed for the presence of marrow oedema and cortical integrity. Fracture healing patterns were characterised on follow-up CT imaging. Twenty-five incomplete fractures were identified in 23 patients on CT. All fractures involved the inferior or infero-medial cortex of the pars and propagated superiorly or superolaterally. Ninety-two percent of incomplete fractures demonstrated either complete or partial healing on follow-up imaging. Two (8%) cases progressed to complete fractures. Thirteen incomplete fractures in 11 patients confirmed on CT also had MRI, and 92% demonstrated oedema in the pars. Ten out of thirteen fractures (77%) showed a break in the infero-medial cortex with intact supero-lateral cortex, which correlated with the CT findings. MRI incorrectly graded one case as a complete (grade 3) fracture, and 2 cases as (grade 1) stress reaction. Six fractures had follow-up MRI, 67% showed partial or complete cortical healing, and the same number showed persistent marrow oedema. Incomplete fracture of the pars interarticularis represents a stage of the evolution of a complete stress fracture. The direction of fracture propagation is consistent, and complete healing can be achieved in most cases with appropriate clinical management. CT best demonstrates fracture size and extent, and is the most appropriate modality for follow-up. MRI is limited in its ability to fully depict the cortical integrity of

  4. Cardiovascular risk prediction in the general population with use of suPAR, CRP, and Framingham Risk Score

    Lyngbæk, Stig; Marott, Jacob L; Sehestedt, Thomas;

    2013-01-01

    men (p=0.034) and borderline significant for women (p=0.054), while the integrated discrimination improvement was highly significant (P≤0.001) for both genders. CONCLUSIONS: suPAR provides prognostic information of CVD risk beyond FRS and improves risk prediction substantially when combined with CRP...

  5. Assessment of Anterior Segment Changes in Pseudophakic Eyes, Using Ultrasonic Biomicroscopic Imaging, after Pars Plana Vitrectomy with Silicone Oil or Gas Tamponade

    Kızılay, Osman

    2016-01-01

    Objective. To evaluate the morphological changes of the anterior segment using ultrasonic biomicroscopy (UBM) imaging in pseudophakic patients who underwent pars plana vitrectomy (PPV) with silicone oil or gas (C3F8) internal tamponade agent injection. Method. This prospective study included pseudophakic patients with planned PPV, divided into two groups according to internal tamponade agent: those in which silicone oil was used (n = 27, Group 1) and those in which gas (C3F8) was used (n = 24, Group 2). UBM measurements were performed in the supine position before and one week after surgery. Results. In patients of Group 1, postoperative trabecular meshwork-ciliary process distance (T-CPD) and iris-ciliary process distance (I-CPD), according to preoperative values, were found to be statistically significantly reduced, and postoperative mean value of scleral thickness (ST) and intraocular pressure (IOP), according to preoperative value, was found to be statistically significantly increased. In patients of Group 2, postoperative mean values of anterior chamber depth (ACD), ciliary body thickness (CBT), T-CPD, I-CPD, and IOP, according to preoperative values, were found to be statistically significantly reduced. Preoperatively, in Group 2 patients, according to Group 1 patients, TIA and IOP were found to be statistically significantly increased. Preoperative and postoperative IOP between the measured parameters with UBM showed no statistically significant correlation. Conclusions. Gases cause more morphological changes in the anterior segment structures. It is thought that complications such as increased intraocular pressure can be seen more frequently for this reason. PMID:27298733

  6. ParMap, an algorithm for the identification of small genomic insertions and deletions in nextgen sequencing data

    Palomero Teresa

    2010-05-01

    Full Text Available Abstract Background Next-generation sequencing produces high-throughput data, albeit with greater error and shorter reads than traditional Sanger sequencing methods. This complicates the detection of genomic variations, especially, small insertions and deletions. Findings Here we describe ParMap, a statistical algorithm for the identification of complex genetic variants, such as small insertion and deletions, using partially mapped reads in nextgen sequencing data. Conclusions We report ParMap's successful application to the mutation analysis of chromosome X exome-captured leukemia DNA samples.

  7. ParABS system in chromosome partitioning in the bacterium Myxococcus xanthus.

    Antonio A Iniesta

    Full Text Available Chromosome segregation is an essential cellular function in eukaryotic and prokaryotic cells. The ParABS system is a fundamental player for a mitosis-like process in chromosome partitioning in many bacterial species. This work shows that the social bacterium Myxococcus xanthus also uses the ParABS system for chromosome segregation. Its large prokaryotic genome of 9.1 Mb contains 22 parS sequences near the origin of replication, and it is shown here that M. xanthus ParB binds preferentially to a consensus parS sequence in vitro. ParB and ParA are essential for cell viability in M. xanthus as in Caulobacter crescentus, but unlike in many other bacteria. Absence of ParB results in anucleate cells, chromosome segregation defects and loss of viability. Analysis of ParA subcellular localization shows that it clusters at the poles in all cells, and in some, in the DNA-free cell division plane between two chromosomal DNA masses. This ParA localization pattern depends on ParB but not on FtsZ. ParB inhibits the nonspecific interaction of ParA with DNA, and ParA colocalizes with chromosomal DNA only when ParB is depleted. The subcellular localization of ParB suggests a single ParB-parS complex localized at the edge of the nucleoid, next to a polar ParA cluster, with a second ParB-parS complex migrating after the replication of parS takes place to the opposite nucleoid edge, next to the other polar ParA cluster.

  8. Identification des gaz combustibles par capteur catalytique

    Rose, Gérard

    1995-01-01

    L'explosimètre est un instrument destiné à prévenir le risque d'inflammation d'un mélange d'air et de gaz en informant de la présence du gaz par une alarme, et en délivrant une mesure qu'il exprime en pourcentage de la limite inférieure d'explosivité du mélange (LIE). Il répond à tous les gaz et vapeurs combustibles, mais il ne donne une mesure juste que pour un seul d'entre-eux : celui pour lequel il a été étalonné. Cet inconvénient est sans conséquence si l'utilisateur identifie le gaz, car...

  9. Parálisis cerebral Cerebral palsy

    Jorge Malagon Valdez

    2007-01-01

    El término parálisis cerebral (PC) engloba a un gran número de síndromes neurológicos clínicos, de etiología diversa. Estos síndromes se caracterizan por tener una sintomatología común: los trastornos motores. Algunos autores prefieren manejar términos como "encefalopatía fija", "encefalopatías no evolutivas". Se mencionan la utilidad de programas de intervención temprana y métodos especiales de rehabilitación, así como el manejo de las deficiencias asociadas como la epilepsia, deficiencia me...

  10. Taare Zameen Par and dyslexic savants.

    Chakravarty, Ambar

    2009-04-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were probably affected with developmental learning disorders. It has been hypothesized that a developmental delay in the dominant hemisphere most likely 'disinhibits' the nondominant parietal lobe, unmasking talents-artistic or otherwise-in some such individuals. It has been suggested that, in remedial training, children with learning disorders be encouraged to develop such hidden talents to full capacity, rather than be subjected to the usual overemphasis on the correction of the disturbed coded symbol operations. PMID:20142854

  11. Taare Zameen Par and dyslexic savants

    Chakravarty Ambar

    2009-01-01

    Full Text Available The film Taare Zameen Par (Stars upon the Ground portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were probably affected with developmental learning disorders. It has been hypothesized that a developmental delay in the dominant hemisphere most likely ′disinhibits′ the nondominant parietal lobe, unmasking talents-artistic or otherwise-in some such individuals. It has been suggested that, in remedial training, children with learning disorders be encouraged to develop such hidden talents to full capacity, rather than be subjected to the usual overemphasis on the correction of the disturbed coded symbol operations.

  12. Paris vu par Jaime Gil de Biedma

    Massip, Estrella

    2013-01-01

    Le poème París, postal del cielo de l’écrivain barcelonais en langue castillane Jaime Gil de Biedma (1929-1990) laisse entendre une multiplicité de voix dont chacune nous communique une image de Paris. C’est la mémoire du « je » poétique qui filtre cette polyphonie. Le voyage dans le Paris réel qui est à l’origine du poème est aussi le voyage de Gil de Biedma lecteur dans le double littéraire de cette ville. Les rapports intertextuels avec les œuvres de Blas de Otero et de Baudelaire permette...

  13. Plasma suPAR is lowered by smoking cessation

    Eugen-Olsen, Jesper; Ladelund, Steen; Sørensen, Lars Tue

    2016-01-01

    46 never smokers (1·9 ng/mL (1·7-2·2)). In smokers randomized to smoking cessation, suPAR levels after 4 weeks of stopping were decreased and no longer significantly different from the never smokers values. SuPAR decreased in both those who received a placebo as well as nicotine patch. Interestingly...

  14. Road tunnels safety according to European legislation

    Fedor KÁLLAY

    2008-01-01

    Full Text Available The article deals with safety of European road tunnels in accordance with actual European legislation. Standards and recommendations of European Commission, PIARC and other professional bodies of the European Union define minimal technological requirements for equipment and operation of the tunnels in scope of Trans-European Road Network.

  15. Contribution a l'industrialisation du soudage par friction malaxage

    Zimmer, Sandra

    2009-01-01

    Le soudage par friction malaxage, ou FSW, est un procédé de soudage à l'« état solide » permettant d'éviter certains problèmes rencontrés en soudage par fusion comme la fissuration à chaud ou la création de soufflures. La soudure est réalisée par l'action d'un outil à l'interface de deux pièces à souder. Celui-ci a pour rôle de malaxer et d'échauffer par frottement la matière. Le cordon est réalisé de proche en proche. Les efforts générés à l'interface outil/matière doivent être repris par la...

  16. ANISOTROPIE STRUCTURELLE INDUITE PAR L'ETIRAGE A CHAUD D'UNE PREFORME EN SILICE PURE – ETUDE PAR DYNAMIQUE MOLECULAIRE ET PAR SPECTROMETRIE RAMAN

    Bidault, Xavier; Chaussedent, Stéphane; Blanc, Wilfried; R. Neuville, D.

    2014-01-01

    Cette étude révèle un nouvel aspect sur la structure de la silice à l'échelle nanométrique. L'orientation acquise par les petits anneaux (Si-O) n pour n ≤ 5 suite à la déformation à chaud persiste à froid et induit une anisotropie structurale dont la forme « isotropie transverse » est vérifiée par spectrométrie Raman.

  17. Corneal topographic changes after 20-gauge pars plana vitrectomy associated with scleral buckling for the treatment of rhegmatogenous retinal detachment

    Alexandre Achille Grandinetti

    2013-04-01

    Full Text Available PURPOSE: To evaluate the changes in corneal topography after 20-gauge pars plana vitrectomy associated with scleral buckling for the repair of rhegmatogenous retinal detachment. METHODS: Twenty-five eyes of 25 patients with rhegmatogenous retinal detachment were included in this study. 20-gauge pars plana vitrectomy associated with scleral buckling was performed in all patients. The corneal topography of each was measured before surgery and one week, one month, and three months after surgery by computer-assisted videokeratoscopy. RESULTS: A statistically significant central corneal steepening (average, 0,9 D , p<0,001 was noted one week after surgery. The total corneal astigmatism had a significant increase in the first postoperative month (p=0,007. All these topographic changes persisted for the first month but returned to preoperative values three months after the surgery. CONCLUSION: Pars plana vitrectomy with scleral buckling was found to induce transient changes in corneal topography.

  18. Recombination in the human Pseudoautosomal region PAR1.

    Anjali G Hinch

    2014-07-01

    Full Text Available The pseudoautosomal region (PAR is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome.

  19. Recombination in the human Pseudoautosomal region PAR1.

    Hinch, Anjali G; Altemose, Nicolas; Noor, Nudrat; Donnelly, Peter; Myers, Simon R

    2014-07-01

    The pseudoautosomal region (PAR) is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome. PMID:25033397

  20. Imprecise information and multicriteria decision-aid models : identification and use of robust conclusions

    Dias, Luís Miguel Cândido

    2001-01-01

    Esta dissertação estuda a utilização de modelos matemáticos no apoio à avaliação de um conjunto de acções (alternativas, projectos) definido em extensão, perante a existência de arbitrariedade, incerteza, imprecisão ou contradição acerca do valor dos seus parâmetros. Centramo-nos em modelos de avaliação multicritério, nos quais os parâmetros podem influenciar os desempenhos das acções e a forma como são avaliados. Propomos que se avance no processo de decisão com informação imprecisa, podendo...

  1. The effective impacts of Angi- Pars on Expression of Some CXC Chemokines Group in STZ-Induced Diabetic Rats

    mm Taghavi

    2013-09-01

    Full Text Available Abstract Background & aim: Diabetes mellitus (DM has destructive tissue effects via inducing oxidative stress. The aim of this study was to evaluate the Angi Pars effects on the expression of some CXC group of streptozotocin-induced diabetic rats. Methods: This experimental study was conducted on 48 male rats. Induced diabetic rats were done by 50 mg/ kg of Streptozotocin. 56 days after induction of diabetes, rats were randomly divided into 4 groups including control, untreated diabetic, insulin-treated diabetic and diabetic treated with insulin and Angipars. 24 h after the last injection the animals were bled and the expression of cxc Chemokines groups were measured by western blotting. Data were analyzed by t test. Results: Showed that CXCL10 was reduced in the treatment group and the treatment group receiving insulin in combination with angi - pars decreased significantly (P<0.05. The total concentration of CXCL12 chemokine showed that the concentration of the different groups did not change compared to the control group (P<0.05. The study showed that CXCL1 levels in the group receiving insulin in combination with angi-pars the chemokine concentration was significantly lower than the control group (P<0.05. Conclusion: Since, Angi-Pars consists of two major phenolic compound groups, 7 - hydroxy coumarin and flavonoids, has antioxidant, and controls the inflammatory effects of chemokine increase and balances between chemokines its effectiveness in angiogenesis can be maintain. Key words: Diabetes, Angi- Pars, Chemokines

  2. Comparison between Limbal and Pars Plana Approaches Using Microincision Vitrectomy for Removal of Congenital Cataracts with Primary Intraocular Lens Implantation

    Liu, Xin; Zheng, Tianyu; Zhou, Xingtao; Lu, Yi; Zhou, Peng; Fan, Fan; Luo, Yi

    2016-01-01

    Purpose. To compare the surgical outcomes of limbal versus pars plana vitrectomy using the 23-gauge microincision system for removal of congenital cataracts with primary intraocular lens implantation. Methods. We retrospectively reviewed all eyes that underwent cataract removal through limbal or pars plana incision. Main outcome measures included visual outcomes and complications. Results. We included 40 eyes (26 patients) in the limbal group and 41 eyes (30 patients) in the pars plana group. The mean age was 46 months. There was no significant difference in best-corrected visual acuity between the two groups (P = 0.64). Significantly, more eyes had at least one intraoperative complication in the limbal group than in the pars plana group (P = 0.03) that were mainly distributed at 1.5–3 years of age (P = 0.01). The most common intraoperative complications were iris aspiration, iris prolapse, and iris injury. More eyes in the limbal group had postoperative complications and required additional intraocular surgery, but the difference was not significant (P = 0.19). Conclusions. The visual results were encouraging in both approaches. We recommend the pars plana approach for lower incidence of complications. The limbal approach should be reserved for children older than 3 years of age and caution should be exercised to minimize iris disturbance. PMID:27313872

  3. Paracrine Apoptotic Effect of p53 Mediated by Tumor Suppressor Par-4

    Ravshan Burikhanov; Tripti Shrestha-Bhattarai; Nikhil Hebbar; Shirley Qiu; Yanming Zhao; Gerard P. Zambetti; Vivek M. Rangnekar

    2014-01-01

    The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apoptosis in p53-deficient cancer cells. This paracrine effect was mediated by p53-dependent secretion of the tumor suppressor Par-4. Accordingly, the activation of p53 in normal mice...

  4. Classification of lubricants according to cavitation criteria

    Meged, Y.; Venner, C.H.; Napel, ten, H.M.Th.D.

    1995-01-01

    Cavitation in lubrication liquids has long been known to be detrimental to components in hydraulic systems. Damage has been detected in journal bearings, especially under severe dynamic loading, gears, squeeze film dampers and valves. These findings have led to intensive studies of metal resistance to cavitation erosion, in order to minimize the damage. Results of these studies have been: 1. (a) classification of known materials according to their resistance to cavitation erosion; 2. (b) deve...

  5. Phacoemulsification and pars plana vitrectomy: A combined procedure

    Jain Vandana

    2007-01-01

    Full Text Available Aim: To describe the results of a combined procedure including phacoemulsification, insertion of posterior chamber intraocular lens (PCIOL and pars plana vitrectomy (PPV in eyes with vitreoretinal pathology and coexisting significant cataract. Design: Retrospective, consecutive, noncomparative, interventional case series. Materials and Methods: Medical records of patients who had undergone phacoemulsification, PPV and PCIOL implantation as a combined procedure between January 2000 and December 2004 were retrospectively reviewed. The main outcome measures were the anatomical success of retina, defined as reattached retina, intraoperative and postoperative complications and functional success in terms of final best corrected visual acuity. Results: In all, 65 eyes of 64 patients were included. The mean age of the patients was 50.9 years ± 17.1 (range, five to 82 years. Vitreous hemorrhage with or without retinal detachment (19 eyes, 29.2% was the most common indication for the vitreoretinal procedure. Primary anatomical success of retina was achieved in 59 eyes (90.7%. Visual acuity improved in 48 eyes (73.8%, was unchanged in 12 eyes (18.5% and deteriorated in five eyes (7.7%. Postoperative inflammation was significantly more in the subgroup of previously vitrectomized eyes (42% ( P =0.014, Fisher exact test compared to those which underwent primary vitrectomy. Conclusions: Combined surgery is a feasible option for patients with vitreoretinal diseases and cataract.

  6. PARs for combustible gas control in advanced light water reactors

    This paper discusses the progress being made in the United States to introduce passive autocatalytic recombiner (PAR) technology as a cost-effective alternative to electric recombiners for controlling combustible gas produced in postulated accidents in both future Advanced Light Water Reactors (ALWRs) and certain U. S. operating nuclear plants. PARs catalytically recombine hydrogen and oxygen, gradually producing heat and water vapor. They have no moving parts and are self-starting and self-feeding, even under relatively cold and wet containment conditions. Buoyancy of the hot gases they create sets up natural convective flow that promotes mixing of combustible gases in a containment. In a non-inerted ALWR containment, two approaches each employing a combination of PARs and igniters are being considered to control hydrogen in design basis and severe accidents. In pre-inerted ALWRs, PARs alone control radiolytic oxygen produced in either accident type. The paper also discusses regulatory feedback regarding these combustible gas control approaches and describes a test program being conducted by the Electric Power Research Institute (EPRI) and Electricite de France (EdF) to supplement the existing PAR test database with performance data under conditions of interest to U.S. plants. Preliminary findings from the EPRI/EdF PAR model test program are included. Successful completion of this test program and confirmatory tests being sponsored by the U. S. NRC are expected to pave the way for use of PARs in ALWRs and operating plants. (author)

  7. The inflammatory marker suPAR after cardiac arrest

    Rundgren, Malin; Lyngbaek, Stig; Fisker, Helle; Friberg, Hans

    2015-01-01

    pilot study aimed at investigating suPAR levels in relation to outcome after CA and mild induced hypothermia. METHODS: suPAR levels were measured at 6, 36, and 72 hours in patients treated with hypothermia after CA. suPAR levels were analyzed in relation to survival after 6 months. Receiver operating...... characteristic curve (ROC)-analyses were performed, and area under the curve (AUC) was calculated. Time to return of spontaneous circulation (ROSC) was correlated to suPAR levels. RESULTS: Fifty-five patients (40 male, median 65 years) were included, and 33 (60%) were alive after 6 months. The suPAR levels were...... significantly higher in nonsurviving patients compared with survivors at 6 and 36 hours (p=0.006 and 0.034 respectively), but not at 72 hours. The suPAR levels increased from 6 to 72 hours (p<0.0001). Time to ROSC correlated positively with suPAR levels at 6 hours (p=0.003) but not at 36 and 72 hours. ROC...

  8. Endophthalmitis following pars plana vitrectomy for vitreous floaters

    Henry CR

    2014-08-01

    Full Text Available Christopher R Henry, Stephen G Schwartz, Harry W Flynn Jr Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA Abstract: A case of Staphylococcus caprae endophthalmitis in a young patient following pars plana vitrectomy for symptomatic vitreous floaters is reported here. Recent literature suggests that there is an increasing trend of performing pars plana vitrectomy for symptomatic floaters. Although rare, the potential risk of endophthalmitis should be explicitly discussed with patients considering surgical intervention for vitreous floaters. Keywords: endophthalmitis, pars plana vitrectomy, vitreous floaters, floaterectomy, posterior vitreous detachment

  9. First-in-human uPAR PET

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene;

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive of....... The ligand exhibited good in vivo stability and fast clearance from plasma and tissue compartments by renal excretion. In addition, high uptake in both primary tumor lesions and lymph node metastases was seen and paralleled high uPAR expression in excised tumor tissue. Overall, this first-in-human...

  10. Formalisation d'annotations produites par des apprenants

    Mille, Dominique

    2005-01-01

    L'objet de cet article est la description d'une formalisation computable des annotations produites par des apprenants, représentée par une ontologie. Cette formalisation explicite la sémantique des annotations grâce à des attributs auxquels le lecteur devrait donner une valeur. Elle contient également les valeurs possibles de ces attributs. L'intérêt d'une telle formalisation est de couvrir toutes les annotations produites par des apprenants, et d'expliciter tout ce qui constitue leur sens, a...

  11. Limnological database for Par Pond: 1959 to 1980

    A limnological database for Par Pond, a cooling reservoir for hot reactor effluent water at the Savannah River Plant, is described. The data are derived from a combination of research and monitoring efforts on Par Pond since 1959. The approximately 24,000-byte database provides water quality, primary productivity, and flow data from a number of different stations, depths, and times during the 22-year history of the Par Pond impoundment. The data have been organized to permit an interpretation of the effects of twenty years of cooling system operations on the structure and function of an aquatic ecosystem

  12. Initial knowledge at radiation protection courses from 2005-2013 (3). Tendencies and conclusions

    Purpose: The necessity of refresher courses is controversial and is frequently questioned. The present study examines whether the courses have a lasting effect and whether improvements are indicated. Materials and Methods: With the help of a questionnaire (9 questions) to be answered before the course, a self-assessment was performed and questions about the knowledge and structure of radiation protection were asked. 1361 participants were surveyed (55 % physicians, 31 % doctor's assistants, 13 % technicians, 1 % medical physicists) in the period of 2005 - 2013 (3) and 39 courses were evaluated. The assessment entailed the comparison of 3 subgroups: 2005 - 2007, 2008 - 2010, 2011 - 2013. Results: The self-assessment is about 3.0 (1 - very good, 5 - very poor) with fluctuations regarding time course and occupation. For all questions, there was an increase in correct answers from the period 2005 - 2007 to the period 2008 - 2010 (+ 15 %), while the rate fell again for the period 2011 - 2013 (3) (-8 %). The questions were answered significantly better for organization-related topics than knowledge-based topics. Overall 53 % of the answers were correct. Conclusion: This study shows an increase in knowledge since starting refresher courses. However, recently the effect has decreased again. In order to maintain the knowledge, the yearly instruction must be held on time, which according to participants' statements actually occurs in only 60 % of cases. (orig.)

  13. Methodology and conclusions of activation calculations of WWER-440 type nuclear power plants

    Highlights: • Activation calculation of two WWER-440 type nuclear power plants. • Detailed description of the applied activation calculation methodology. • Graphical results for total activity and waste index categorization. • General conclusions for activation applicable in the case of PWR reactors. - Abstract: Activation calculations for two nuclear power plants of WWER-440 type have been performed by the authors in order to assist the decommissioning planning by assessing the radioactive inventory present at the time of and at different times after the final shutdown. According to related international literature and studies performed earlier by the authors, considering the activity more than 99% of this inventory is concentrated in the materials directly surrounding the reactor core, where the predominant evolution of radionuclides is generated by neutron induced nuclear reactions. In order to obtain the highest possible accuracy in modelling, three-dimensional Monte Carlo neutron transport calculations were performed. Besides the methods and models applied to these analyses, the paper also summarizes the results that can be generally applied to such nuclear power plant types. At the time of shutdown, the total activity of the stainless steel components is about 6 × 1016 Bq and 1.3 × 1017 Bq for the two NPPs considered. The biological shielding concrete constitutes approximately 7 × 1013 Bq and 1.1 × 1014 Bq

  14. Reducing greenhouse gases: Promoting an international accord

    This article reports on a Cornell Center for the Environmental sponsored workshop to explore the prospects for reducing atmospheric concentrations of greenhouse gases, carbon dioxide as well as others through voluntary, market-based international accords. Cornell specialists in a range of fields were joined by participants from other universities and policy groups. The topics discussed covered the threat to the biosphere, why international measures are essential, and how they might be implemented. Tradeoffs in terms of emission sources and sinks were explored, along with issues of technology transfer. A panel of experts considered the potential interactions between increases in atmospheric greenhouse gases and agriculture, transportation systems, and national politics. Several participants presented the perspectives of developing nations. Other speakers discussed strategies for effluent monitoring to insure compliance with international accords, including the development and use of remote-sensing technology. The prospects for market-based mechanisms to alleviate other environmental problems, including the threat to biodiversity, were discussed by Cornell biology professor Thomas Eisner

  15. Récolte et consommation de pollen par les abeilles

    Odoux, Jean Francois

    2005-01-01

    La récolte de pollen par les abeilles fait appel à des organes spécialisés de l'abeille, comme celle du nectar. Par contre, elle est régie par de très nombreux facteurs, en fonction des ressources, bien sûr, mais aussi des besoins de la colonie, alors que son attractivité n'est pas toujours en rapport avec la qualité. Ce texte décrit le contexte de l'utilisation du pollen par les abeilles, de la récolte à la digestion, d'après une synthèse bibliographique.

  16. La preuve apportée par les sciences

    1997-04-01

    Full Text Available A propos d´une enquête menée par deux immunologistes de l´Université de Göteborg, rapportée par la très sérieuse revue Nature, le journal Le Monde n´hésitait pas à titrer : " La preuve du sexisme apportée par les sciences ". Les auteurs avaient en effet pu démontrer, irréfutables tests statistiques à l´appui, que, pour obtenir une bourse de post-doctorat offerte par le Swedisch Medical Research Council, les femmes devaient être deux fois et demie plus productives que les hommes ! Nous voulons...

  17. Pars plana vitrectomy for malignant glaucoma in nonglaucomatous and in filtered glaucomatous eyes

    Matlach J

    2012-11-01

    Full Text Available Juliane Matlach, Joerg Slobodda, Franz Grehn, Thomas KlinkDepartment of Ophthalmology, University of Wuerzburg, Wuerzburg, GermanyPurpose: To assess the outcomes of pars plana vitrectomy for the treatment of malignant glaucoma in patients with and without previous filtration surgery.Patients and methods: Data of 15 patients developing malignant glaucoma after trabeculectomy (60% or following ophthalmic interventions other than filtration surgery (40% were recorded retrospectively. Pars plana vitrectomy was performed in case of failed medical or laser treatment recreating the normal pathway of aqueous humor. The main outcome measures were the postoperative intraocular pressure (IOP, the frequency of complications, and success rate based on the following criteria: IOP reduction by ≥20% and to ≤21 mmHg (definition one or an IOP < 18 mmHg (definition two with (qualified success and without (complete success glaucoma medication.Results: Vitrectomy reduced IOP from baseline in eyes with and without previous trabeculectomy during a median follow-up of 16.4 months (range 7 days to 58 months; although the majority of patients required glaucoma medication to reach desired IOP. The complete success rates were 11% (both definitions for patients with filtering blebs and none of the patients without previous trabeculectomy had complete success at the 12-month visit. Complications were few and included transient shallowing of the anterior chamber, choroidal detachment, corneal decompensation, filtering bleb failure, and need for further IOP-lowering procedures.Conclusion: Pars plana vitrectomy is equally effective for malignant glaucoma caused by trabeculectomy or interventions other than filtration surgery, although IOP-lowering medication is necessary in nearly all cases to maintain target IOP.Keywords: ciliolenticular block glaucoma, malignant glaucoma, pars plana vitrectomy, trabeculectomy

  18. Conclusions de les sessions de treball de la II Jornada de Recerca

    Vicerectorat de Recerca i Innovació. Universitat Oberta de Catalunya

    2011-01-01

    L'activitat participativa de la jornada s'ha estructurat en tres grups de treball on es tractaran, a partir de l'experiència de persones de la universitat, 3 aspectes clau de l'activitat de recerca: publicacions científiques, projectes i xarxes temàtiques. The meeting was divided into three working groups which, from the experience of people from the university, have discussed three key areas of research activity: scientific publications, projects and thematic networks. La actividad par...

  19. A turquesa de Itacupim, Pará

    Marcondes Lima da Costa

    2004-12-01

    Full Text Available Na ilha de Itacupim, localizada na região costeira do nordeste do Pará, foram encontrados veios de fosfatos de alumínio contendo turquesa, além de quartzo e argilominerais. A ilha é sustentada por espesso perfil laterítico maturo desenvolvido sobre complexo alcalino-ultramáfico mineralizado em apatita. Os veios e vênulas são de espessura centimétrica, normalmente constituídos de wavellita fibro-radial, onde pode ser observada turquesa verde-azulada, em massas subesferolíticas, microcristalinas, intercrescidas com caulinita e oxi-hidróxidos de Mn, além de quartzo. A identificação mineral foi realizada por DRX, microscopia óptica, análises químicas de rocha total, MEV/SED. Os teores de CuO são inferiores aos das turquesas em geral, compensados por Fe2O3 e ZnO. Os subesferolitos de turquesa contêm inúmeras inclusões micrométricas de goyazita ou svanbergita. A ocorrência da turquesa, na forma de veios e vênulas, seu aspecto porcelanado e a conhecida relação desse mineral com ambiente hidrotermal sugerem que a turquesa de Itacupim também seja de origem hidrotermal, reforçada pela sua associação com wavellita, goyazita ou svanbergita, quartzo e argilominerais. Ela não foi encontrada no perfil laterítico. Seu aspecto compacto e sua cor esverdeada abrem perspectivas para seu uso como mineral de gema.Veins and veinlets of aluminum phosphates with turquoise occur at the Itacupim Island in the coastal plain northeast the state of Pará. A thick mature lateritic iron crust rich in aluminum phosphates developed an apatite-bearing alkaline-ultramafic complex which constitutes the Island. The veins and veinlets are cm-thick, usually constituted by wavellite, fibrous to radialfibrous, with bony or porcelaneous aspect, and can turquoise. Pebbles of these phosphates inside of apatite-bearing ultramafic rocks are very common at the base of the hang wall, and locally form expressive agglomerates. Turquoise forms half spheroids and

  20. Reducing Tariffs According to WTO Accession Rules

    Fosse, Henrik Barslund; Raimondos-Møller, Pascalis

    2012-01-01

    When Vietnam joined the World Trade Organization (WTO) in 2007 it was granted an accession period up to 2014. During this period tariffs would have to fall according to the accession agreement. This paper evaluates this 2007–2014 trade liberalization by building an applied general equilibrium model...... and calibrating it to the Vietnamese data. The model pays careful attention to the fact that Vietnam has many state-owned enterprises. The model simulations show that the WTO tariff reductions will reduce overall welfare. Moreover, the biggest loss will take place among the poor rural households in...... Vietnam. This paper proposes other tariff reforms that will both raise overall welfare and reduce income inequality....

  1. Bee Venom Pharmacopuncture Responses According to Sasang Constitution and Gender

    Kim Chaeweon

    2013-12-01

    Full Text Available Objectives: The current study was performed to compare the bee venom pharmacopuncture skin test reactions among groups with different sexes and Sasang constitutions. Methods: Between July 2012 and June 2013, all 76 patients who underwent bee venom pharmacopuncture skin tests and Sasang constitution diagnoses at Oriental Medicine Hospital of Sangji University were included in this study. The skin test was performed on the patient’s forearm intracutaneously with 0.05 ml of sweet bee venom (SBV on their first visit. If the patients showed a positive response, the test was discontinued. On the other hand, if the patient showed a negative response, the test was performed on the opposite forearm intracutaneously with 0.05 ml of bee venom pharmacopuncture 25% on the next day or the next visit. Three groups were made to compare the differences in the bee venom pharmacopuncture skin tests according to sexual difference and Sasang constitution: group A showed a positive response to SBV, group B showed a positive response to bee venom pharmacopuncture 25%, and group C showed a negative response on all bee venom pharmacopuncture skin tests. Fisher’s exact test was performed to evaluate the differences statistically. Results: The results of the bee venom pharmacopuncture skin tests showed no significant differences according to Sasang constitution (P = 0.300 or sexual difference (P = 0.163. Conclusion: No significant differences on the results of bee venom pharmacopuncture skin tests were observed according to two factors, Sasang constitution and the sexual difference.

  2. Parálisis cerebral Cerebral palsy

    Jorge Malagon Valdez

    2007-01-01

    Full Text Available El término parálisis cerebral (PC engloba a un gran número de síndromes neurológicos clínicos, de etiología diversa. Estos síndromes se caracterizan por tener una sintomatología común: los trastornos motores. Algunos autores prefieren manejar términos como "encefalopatía fija", "encefalopatías no evolutivas". Se mencionan la utilidad de programas de intervención temprana y métodos especiales de rehabilitación, así como el manejo de las deficiencias asociadas como la epilepsia, deficiencia mental, trastornos del lenguaje, audición, visión, déficit de la atención que mejoran el pronóstico de manera significativa. El pronóstico también depende de la gravedad del padecimiento y de las manifestaciones asociadas.The term cerebral palsy (CP, is used for a great number of clinical neurological syndromes. The syndromes are characterized by having a common cause, motor defects. It is important, because they can cause a brain damage by presenting motor defects and some associated deficiencies, such as mental deficiency, epilepsy, language and visual defects and pseudobulbar paralysis, with the nonevolving fact. Some authors prefer using terms such as "non-evolving encephalopathies". In the treatment the utility of prevention programs of early stimulation and special rehabilitation methods, and treatment of associated deficiencies such as epilepsy, mental deficiency, language, audition and visual problems, and the attention deficit improve the prognosis in an important way. The prognosis depends on the severity of the disease and the associated manifestations.

  3. Croissance epitaxiale de GaAs sur substrats de Ge par epitaxie par faisceaux chimiques

    Belanger, Simon

    La situation energetique et les enjeux environnementaux auxquels la societe est confrontee entrainent un interet grandissant pour la production d'electricite a partir de l'energie solaire. Parmi les technologies actuellement disponibles, la filiere du photovoltaique a concentrateur solaire (CPV pour concentrator photovoltaics) possede un rendement superieur et mi potentiel interessant a condition que ses couts de production soient competitifs. La methode d'epitaxie par faisceaux chimiques (CBE pour chemical beam epitaxy) possede plusieurs caracteristiques qui la rendent interessante pour la production a grande echelle de cellules photovoltaiques a jonctions multiples a base de semi-conducteurs III-V. Ce type de cellule possede la meilleure efficacite atteinte a ce jour et est utilise sur les satellites et les systemes photovoltaiques a concentrateur solaire (CPV) les plus efficaces. Une des principales forces de la technique CBE se trouve dans son potentiel d'efficacite d'utilisation des materiaux source qui est superieur a celui de la technique d'epitaxie qui est couramment utilisee pour la production a grande echelle de ces cellules. Ce memoire de maitrise presente les travaux effectues dans le but d'evaluer le potentiel de la technique CBE pour realiser la croissance de couches de GaAs sur des substrats de Ge. Cette croissance constitue la premiere etape de fabrication de nombreux modeles de cellules solaires a haute performance decrites plus haut. La realisation de ce projet a necessite le developpement d'un procede de preparation de surface pour les substrats de germanium, la realisation de nombreuses sceances de croissance epitaxiale et la caracterisation des materiaux obtenus par microscopie optique, microscopie a force atomique (AFM), diffraction des rayons-X a haute resolution (HRXRD), microscopie electronique a transmission (TEM), photoluminescence a basse temperature (LTPL) et spectrometrie de masse des ions secondaires (SIMS). Les experiences ont permis

  4. The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180)

    Behrendt, Niels

    2004-01-01

    processes involve a highly organized interplay between proteases and their cellular binding sites as well as specific substrates and internalization receptors. This review article is focused on two components, the urokinase plasminogen activator receptor (uPAR) and the uPAR-associated protein (uPARAP, also......The breakdown of the barriers formed by extracellular matrix proteins is a pre-requisite for all processes of tissue remodeling. Matrix degradation reactions take part in specific physiological events in the healthy organism but also represent a crucial step in cancer invasion. These degradation...... designated Endo180), that are considered crucially engaged in matrix degradation. uPAR and uPARAP have highly diverse functions, but on certain cell types they interact with each other in a process that is still incompletely understood. uPAR is a glycosyl-phosphatidylinositol-anchored glycoprotein on the...

  5. Technological processes optimisation according to MSTP procedure

    R. Nowosielski

    2008-12-01

    Full Text Available Purpose: The paper presents optimization of technological processes according to MSTP (Modified SustainableTechnology Procedure procedure by general analysis and estimation (with regard to BREF-BAT ReferenceDocuments of three realistic zinc plating technological processes.Design/methodology/approach: In this article one of the polyoptimization methods - genetic algorithms (GAfor technological processes optimization has been proposed. As well as the universal software Poli-Opt version1.0 for technological processes optimization has been presented.Findings: Polyoptimization using simple genetic algorithms makes possible negative environmental influencesminimization. It also leading to ideal process obtaining that in reality does not exist.Research limitations/implications: The optimum solution in polyoptimization process is not absolutelyoptimum. This solution is about the largest probability of optimum obtaining. This results from the fact ofdifferent criteria and different objective function values using.Practical implications: The simple and universal Poli-Opt version 1.0 software using elementary, but quitesufficient in practice, genetic algorithm could be in every company applied.Originality/value: The Modified Sustainable Technology Procedure with computer supported could be forevery materials technological processes optimization used.

  6. Elevated urinary levels of urokinase-type plasminogen activator receptor (uPAR in pancreatic ductal adenocarcinoma identify a clinically high-risk group

    Brocco Giorgio

    2011-10-01

    Full Text Available Abstract Background The urokinase plasminogen activator receptor is highly expressed and its gene is amplified in about 50% of pancreatic ductal adenocarcinomas; this last feature is associated with worse prognosis. It is unknown whether the level of its soluble form (suPAR in urine may be a diagnostic-prognostic marker in these patients. Methods The urinary level of suPAR was measured in 146 patients, 94 pancreatic ductal adenocarcinoma and 52 chronic pancreatitis. Urine from 104 healthy subjects with similar age and gender distribution served as controls. suPAR levels were normalized with creatinine levels (suPAR/creatinine, ng/mg to remove urine dilution effect. Results Urinary suPAR/creatinine values of pancreatic ductal adenocarcinoma patients were significantly higher (median 9.8; 25th-75th percentiles 5.3-20.7 than those of either healthy donors (median 0; 0-0.5 or chronic pancreatitis patients (median 2.7; 0.9-4.7. The distribution of values among cancer patients was widespread and asymmetric, 53% subjects having values beyond the 95th percentile of healthy donors. The values of suPAR/creatinine did not correlate with tumour stage, Ca19-9 or CEA levels. Higher values correlated with poor prognosis among non-resected patients at univariate analysis; multivariate Cox regression identified high urinary suPAR/creatinine as an independent predictor of poor survival among all cancer patients (odds ratio 2.10, p = 0.0023, together with tumour stage (stage III odds ratio 2.65, p = 0.0017; stage IV odds ratio 4.61, p Conclusions A high urinary suPAR/creatinine ratio represents a useful marker for the identification of a subset of patients with poorer outcome.

  7. Outcome of early pars plana vitrectomy in exogenous endophthalmitis

    Objective: To evaluate the role of early pars plana vitrectomy (PPV) in cases of exogenous endophthalmitis in terms of final visual outcome and to determine association between various study variables and final visual outcome. Study Design: Quasi experimental study. Place and Duration of Study: Armed Forces Institute of Ophthalmology (AFIO) Rawalpindi, from Aug 2010 to May 2012. Patients and Methods: Eleven cases of exogenous endophthalmitis (post surgical/post traumatic) were managed surgically through 20 G or 23/25 G complete and early PPV. Vitreous aspirate/explanted intraocular lens (IOL) were sent for culture and sensitivity in all cases. Intra and post operative complications were recorded and best corrected visual acuity (BCVA) at 3 months post operative interval was taken as final visual acuity. Results: Median age of study population was 55 years with male preponderance (64%). Approximately 2/3 rd of study population developed endophthalmitis within 6 weeks of surgery/trauma and 55% of patients were operated within 2 weeks of presentation. Positive culture from vitreous aspirate/IOL explant was obtained in 27% of cases. All the patients had initial BCVA in the range of counting finger (CF) at 2 meter to perception of light (PL+). However, 18% of the patients achieved final BCVA of 6/12 or better and 64% achieved final BCVA of 6/36 or better. Maculopathy (macular scar, macular pucker), corneal decompensation, corneal opacity and raised intraocular pressure were the major complications associated with compromised visual outcome. Conclusion: With the advancement in vitreoretinal surgical techniques and availability of more sophisticated viewing and illumination systems, early and complete vitrectomy for post operative or post traumatic endophthalmitis results in favorable visual outcome and early rehabilitation. (author)

  8. Pars Plana Vitrectomy and Intravitreal Phacoemulsification for Dropped Nuclei

    Khalil Ghasemi Falavarjani

    2012-01-01

    Full Text Available Purpose: To report the outcomes of pars plana vitrectomy (PPV and intravitreal phacoemulsification in patients with dropped nuclei/nuclear fragments following complicated cataract surgery. Methods: In this retrospective case series, charts of patients who had undergone PPV and intravitreal phacoemulsification for removal of dislocated nuclei/lens fragments were reviewed. After standard PPV, a conventional phacoemulsification probe with an amputated sleeve was used for grasping and emulsifying the nucleus/nuclear fragments in mid/anterior vitreous cavity. Pre- and postoperative visual acuity, and intra- and postoperative complications were recorded. Results: A total of 22 patients with mean age of 71.1΁8.2 years were studied. Mean interval between complicated cataract surgery and PPV was 26.6΁36.5 (range: 0-120 days. Patients were followed for a mean of 105.5΁57.5 days. Preoperatively, best corrected visual acuity was 2.4΁0.6 logMAR which was improved to 1.4΁0.6 logMAR at final follow-up (P<0.001. Intraoperative complications included iatrogenic peripheral retinal breaks in three eyes. Postoperative complications consisted of epiretinal membrane formation in one eye, hypotony in one eye, and medically-controlled glaucoma in 2 eyes. Conclusion: In this series, PPV and intravitreal phacoemulsification using a conventional phacoemulsification probe in patients with dropped nuclei/nuclear fragments following complicated cataract surgery resulted in visual improvement without any complications directly attributable to the probe.

  9. Pars planitis: Epidemiology, clinical characteristics, management and visual prognosis

    Pinar Cakar Ozdal

    2015-01-01

    Full Text Available Pars planitis is an idiopathic chronic intermediate uveitis which predominantly affects children and adolescents, and accounts for 5-26.7% of pediatric uveitis. Although an autoimmune process with a genetic predisposition has been suggested, its etiology still remains unknown. The most common presenting symptoms are floaters and blurred vision. Diffuse vitreous cells, haze, snowballs and snowbanks are typical findings of pars planitis. Peripheral retinal vasculitis, optic disc edema and anterior segment inflammation are other well-known findings. Although pars planitis is known to be a benign form of uveitis in most cases, it may become a potentially blinding disease due to complications including cataract, cystoid macular edema, vitreous opacities and optic disc edema. Cystoid macular edema is the most common cause of visual morbidity. Band keratopathy, epiretinal membrane formation, vitreous condensation, neovascularizations, vitreous hemorrhage, retinal detachment, cyclitic membranes, glaucoma and amblyopia may develop as a consequence of the chronic course of the disease. Exclusion of infectious and non-infectious causes which may present with intermediate uveitis is of utmost importance before starting treatment. Treatment of pars planitis has been a controversial issue. There is no consensus specifically for treatment of cases with minimal inflammation and relatively good visual acuity. However, current experience shows that pars planitis may cause severe inflammation and needs an aggressive treatment. A stepladder approach including corticosteroids, immunosupressive agents, anti-tumor necrosis factor-alpha and pars plana vitrectomy and/or laser photocoagulation is the most commonly used method for treatment of pars planitis. Adequate control of inflammation and prompt detection of associated complications are crucial in order to improve the overall prognosis of the disease.

  10. Par Pond vegetation status Summer 1995 -- June survey descriptive summary

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the shoreline aquatic plant communities in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level, indicated that much of the original plant communities and the intermediate shoreline communities present on the exposed sediments have been lost. The extensive old-field and emergent marsh communities that were present on the exposed shoreline during the drawdown have been flooded and much of the pre-drawdown Par Pond aquatic plant communities have not had sufficient time for re-establishment. The shoreline does, however, have extensive beds of maidencane which extend from the shoreline margin to areas as deep as 2 and perhaps 3 meters. Scattered individual plants of lotus and watershield are common and may indicate likely directions of future wetland development in Par Pond. In addition, within isolated coves, which apparently received ground water seepage and/or stream surface flows during the period of the Par Pond draw down, extensive beds of waterlilies and spike rush are common. Invasion of willow and red maple occurred along the lake shoreline as well. Although not absent from this survey, evidence of the extensive redevelopment of the large cattail and eel grass beds was not observed in this first survey of Par Pond. Future surveys during the growing seasons of 1995, 1996, and 1997 along with the evaluation of satellite date to map the areal extent of the macrophyte beds of Par Pond are planned

  11. Par-4 Down-regulation Promotes Breast Cancer Recurrence by Preventing Multinucleation following Targeted Therapy

    Alvarez, James V.; Pan, Tien-chi; Ruth, Jason; Feng, Yi; Zhou, Alice; Pant, Dhruv; Grimley, Joshua S.; Wandless, Thomas J.; DeMichele, Angela; Chodosh, Lewis A.

    2013-01-01

    Most deaths from breast cancer result from tumor recurrence, but the mechanisms underlying tumor relapse are largely unknown. We now report that Par-4 is down-regulated during tumor recurrence and that Par-4 down-regulation is necessary and sufficient to promote recurrence. Tumor cells with low Par-4 expression survive therapy by evading a program of Par-4-dependent multinucleation and apoptosis that is otherwise engaged following treatment. Low Par-4 expression is associated with poor respon...

  12. Une terreur par l’image

    Annie DULONG

    2011-09-01

    Full Text Available Si d’autres événements — Hiroshima, la découverte des camps de concentration, la chute du mur de Berlin — ont, au cours du XXe siècle, marqué suffisamment l’imaginaire pour trouver leur réponse dans des œuvres d’art, le 11 septembre 2001 pose la question de la fictionnalisation autrement : il ne s’agit plus tant de combler les manques de la représentation, liés à l’absence d’images ou au délai dans leur dévoilement, mais bien de composer avec l’omniprésence d’une représentation martelée à la télévision et sur Internet. Que cette représentation soit partielle, tronquée et qu’il lui manque la présence des corps, ces grands absents des photographies et des images tournées par les journalistes, ne change rien au fait que c’est avec le trop-plein que les artistes doivent maintenant négocier.Cet article s’intéresse aux romans qui traitent l’événement de front au lieu de l’aborder sur un mode mineur, et a pour objectif de tracer un portrait de la représentation des médias dans les romans du 11 septembre 2001. Ces romans, outre le fait qu’ils traitent des événements de New York, ont comme point commun un personnage, ou décor : les médias, représentés par la télévision, l’Internet, les photographies de presse, interviennent dans les récits d’une manière significative et témoignent de la force brute des images. À travers une étude de certains des mécanismes à l’œuvre dans The Writing on the Wall (Lynne Sharon Schwartz, Extremely Loud and Incredibly Close (Jonathan Safran Foer, Falling Man (Don DeLillo et A Disorder Peculiar to the Country (Ken Kalfus, il s’agira de proposer des réponses à ces quelques questions : quel rôle les médias jouent-ils, et comment participent-ils au récit ? Quelle pression les images exercent-elles sur les personnages ? Que révèlent les personnages enfants dans leur rapport aux médias ? Quelle critique, finalement, les romans

  13. Combined pars plana vitrectomy-scleral buckle versus pars plana vitrectomy for proliferative vitreoretinopathy.

    Lai, Frank H P; Lo, Ernie C F; Chan, Vesta C K; Brelen, Mårten; Lo, Wai Ling; Young, Alvin L

    2016-04-01

    The purpose of the study is to evaluate the surgical outcomes of combined pars plana vitrectomy-scleral buckle (PPV-SB) versus pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment complicated with proliferative vitreoretinopathy (PVR). One thousand one hundred and seventy four patients with rhegmatogenous retinal detachment surgery between January 2002 and December 2013 were retrospectively reviewed. Patients with grade C PVR treated with either combined PPV-SB or PPV alone were included in the study. Study outcomes included single surgery anatomic success rate and postoperative visual outcome at 12 months postoperatively. Seventy-seven patients with grade C PVR were identified for analysis. At the end of 12-month follow-up, 80.5 % eyes (33/41) in the PPV-SB group and 58.3 % eyes (21/36) in the PPV group achieved single surgery anatomical success. In a multiple logistic regression model, none of the baseline variables (age, gender, macula status, grade of PVR, extent of detachment, presence of vitreous hemorrhage, lens status, status of high myopia) nor types of retinal detachment surgery (use of scleral buckle, barrier endolaser, 360 degree endolaser, cryopexy, retinectomy, tamponade agent, phacoemulsification) had significant effect on single surgery anatomical success. The post-treatment mean logMAR visual acuity of the PPV-SB group was 1.58 ± 0.58 and the PPV group was 1.57 ± 0.61. There was no significant difference in the postoperative visual acuity between the two groups (P = 0.849). For patients with grade C PVR, PPV-SB did not demonstrate a superiority over PPV alone in achieving single surgery anatomical success. PMID:26260357

  14. Pars plana vitrectomy and silicone oil tamponade for acute endophthalmitis treatment Vitrectomia pars plana e tamponamento por óleo de silicone para o tratamento de endoftalmite aguda

    Rubens Camargo Siqueira

    2009-02-01

    Full Text Available PURPOSE: To evaluate the outcomes of pars plana vitrectomy and silicone oil injection for the treatment of infectious endophthalmitis. METHODS: 35 cases of endophthalmitis secondary to phacoemulsification (20 patients, trabeculectomy (8 patients, perforating trauma (2 patients, trauma (2 patients, corneal transplantation (1 patient, vitrectomy (1 patient and corneal ulceration (1 patient were retrospectively studied. Patients were separated into two groups: Group 1 (n=24: intravitreal antibiotic injection, associated with topical and oral antibiotics; Group 2 (n=11: vitrectomy with intravitreal antibiotic injection and silicone oil injection. The follow-up ranged from 1 to 48 months (mean of 16 months. RESULTS: From 24 patients in group 1, 11 patients (45.83%, had infection controlled with intravitreal antibiotic injection only; 13 patients (54.15% regressed to uncontrolled endophthalmitis, in which two patients (8.33% were submitted to evisceration and one patient (4.16% had corneal melting. The remaining 10 patients (41.66% with uncontrolled endophthalmitis were submitted to pars plana vitrectomy and silicone oil injection. Six patients (25% from Group I had retinal detachment during the first month of follow-up and also required pars plana vitrectomy and silicone oil injection. In Group 2 patients (n=11, all of them had controlled infection at the first procedure. In one case (9.09%, a severe proliferatative vitreoretinopathy induced loss of vision. CONCLUSION: These results suggest that silicone oil tamponade might be beneficial in the treatment strategy of infectious endophthalmitis.OBJETIVO: Avaliar os resultados da vitrectomia pars plana com tamponamento com óleo de silicone no tratamento de endoftalmite aguda. MÉTODOS: Trinta e cinco pacientes com endoftalmite, sendo 20 secundário à facoemulsificação, 8 por trabeculectomia, 2 por trauma perfurante, 2 por trauma, 1 por transplante de córnea, 1 por vitrectomia, e 1 por úlcera de c

  15. HIV testing and clinical status upon admission to a specialized health care unit in Pará, Brazil

    Paulo Afonso Martins Abati

    2015-01-01

    Full Text Available OBJECTIVE To analyze the clinical and laboratory characteristics of HIV-infected individuals upon admission to a reference health care center. METHODS This cross-sectional study was conducted between 1999 and 2010 on 527 individuals with confirmed serological diagnosis of HIV infection who were enrolled in an outpatient health care service in Santarém, PA, Northern Brazil. Data were collected from medical records and included the reason for HIV testing, clinical status, and count of peripheral CD4+ T lymphocytes upon enrollment. The data were divided into three groups, according to the patient’s year of admission – P1 (1999-2002, P2 (2003-2006, and P3 (2007-2010 – for comparative analysis of the variables of interest. RESULTS In the study group, 62.0% of the patients were assigned to the P3 group. The reason for undergoing HIV testing differed between genders. In the male population, most tests were conducted because of the presence of symptoms suggesting infection. Among women, tests were the result of knowledge of the partner’s seropositive status in groups P1 and P2. Higher proportion of women undergoing testing because of symptoms of HIV/AIDS infection abolished the difference between genders in the most recent period. A higher percentage of patients enrolling at a more advanced stage of the disease was observed in P3. CONCLUSIONS Despite the increased awareness of the number of HIV/AIDS cases, these patients have identified their serological status late and were admitted to health care units with active disease. The HIV/AIDS epidemic in Pará presents specificities in its progression that indicate the complex characteristics of the epidemic in the Northern region of Brazil and across the country.

  16. Reclassement d'images par le contenu

    Quenot, Georges; Thollard, Franck

    2012-01-01

    This article presents a method for re-ranking images retrieved by a web scale and state of the art search engine using key words for entering queries. This method uses the visual content of the images and it is based on the idea that the relevant images should be similar to each other while the non relevant images should be different from each other and from relevant images. This idea has been implemented by ranking the images according to their average distances to their nearest neighbors. T...

  17. Les inventions de la musique au Moyen Âge, conclusions

    Daniel Russo

    2010-10-01

    Full Text Available Je commencerai par remercier les organisateurs de la rencontre, Martine Clouzot et Eduardo Aubert, pour la richesse du programme proposé à la discussion et pour l’idée première de réunir les différents intervenants autour de ces questions et de cette problématique de recherche. Je soulignerai, ensuite, quatre lignes principales qui me paraissent devoir retracer l’ensemble des échanges au cours de ces journées très denses.1re ligne Une première direction a été ouverte pour tenter de définir et...

  18. Par Pond vegetation status Summer 1995 -- October survey descriptive summary

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this late October survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maiden cane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  19. Par Pond vegetation status Summer 1995 -- September survey descriptive summary

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this mid-September survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maidencane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys during the late growing seasons of 1995, and throughout 1996 and 1997, along with the evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  20. Medical management of first trimester miscarriage according to ultrasonographic findings

    Vejborg, Thomas; Nilas, Lisbeth; Rørbye, Christina

    2007-01-01

    BACKGROUND: The efficacy of medical treatment of first trimester miscarriages may depend on the regimen used, the definition of success, clinical symptoms, and, possibly, on the ultrasonographic findings. Our primary aim was to assess if a single dose of misoprostol could reduce the number of...... surgical interventions in early pregnancy failure, and to compare efficacy in different ultrasonographically-defined subgroups. METHODS: A retrospective review of 355 consecutive patients treated for a first trimester miscarriage with a single dose of vaginal misoprostol (400 microg), followed by vaginal...... and 3 (43.6%; p<0.05), and the difference was largest in Group B1 (12.9 versus 35.4%; p<0.05). CONCLUSIONS: Single dose misoprostol reduced the number of surgical interventions. The success rates of medically-treated first trimester miscarriages varied according to the ultrasonographic definitions of...

  1. Medical management of first trimester miscarriage according to ultrasonographic findings

    Vejborg, Thomas; Nilas, Lisbeth; Rørbye, Christina

    2007-01-01

    BACKGROUND: The efficacy of medical treatment of first trimester miscarriages may depend on the regimen used, the definition of success, clinical symptoms, and, possibly, on the ultrasonographic findings. Our primary aim was to assess if a single dose of misoprostol could reduce the number of...... and 3 (43.6%; p<0.05), and the difference was largest in Group B1 (12.9 versus 35.4%; p<0.05). CONCLUSIONS: Single dose misoprostol reduced the number of surgical interventions. The success rates of medically-treated first trimester miscarriages varied according to the ultrasonographic definitions of...... surgical interventions in early pregnancy failure, and to compare efficacy in different ultrasonographically-defined subgroups. METHODS: A retrospective review of 355 consecutive patients treated for a first trimester miscarriage with a single dose of vaginal misoprostol (400 microg), followed by vaginal...

  2. Clinical disease characteristics according to karyotype in Turner syndrome

    Chae Young Yeo

    2010-02-01

    Full Text Available Purpose : Turner syndrome (TS is a disorder in which various anomalies can be accompanied, especially cardiovascular, renal, thyroid and auditory problems. The aim of this study is to identify the incidence of these disorders in patients with TS according to karyotype. Methods : We reviewed medical records of 90 patients with TS diagnosed by chromosomal analysis in 4 hospitals from Jan 1998 to Dec 2007. We evaluated these cases by prepared protocol of 4 medical problems. Results : The distribution of karyotype was 45,X (47.8%, mosaic pattern (34.4% and structural aberration group (17.8 %. Renal anomalies, cardiovascular anomalies, thyroid disorders and auditory problems are accompanied in 4.4%, 10.0 %, 11.1% and 5.6%, respectively. 45,X group had renal anomalies (7.0%, cardiovascular anomalies (18.6%, thyroid disorders (9.3% and auditory problems (11.6%. Mosaic group had renal anomalies (3.2%, thyroid disorders (12.9%, no cardiovascular anomalies and auditory problems. Structural aberration group had cardiovascular anomalies (6.3%, thyroid disorders (12.5% and no other 2 problems. Patients with 45,X group had a significant higher incidence of cardiovascular anomalies (P=0.025. Conclusion : Our results indicate that there are differences clinically according to karyotype of TS, especially in incidence of cardiovascular anomalies.

  3. La libéralisation du commerce extérieur égyptien et l'accord du GATT

    'Aziz, Sami; Clément, Françoise

    2008-01-01

    (La présente étude reflète les vues des auteurs, et non celles de la Banque centrale). Après sept ans de négociations sur la libéralisation du commerce mondial, les États membres de l'Accord général sur les tarifs douaniers et le commerce (GATT) sont parvenus, le 15 décembre 1993, à un accord sur toutes les questions soumises aux négociations. Ces questions concernent la libéralisation du commerce de l'habillement et des textiles, précédemment régi par l'Accord multifibres (AMF) et, pour la p...

  4. 10 CFR 2.1209 - Findings of fact and conclusions of law.

    2010-01-01

    ... conclusions of law. Each party shall file written post-hearing proposed findings of fact and conclusions of law on the contentions addressed in an oral hearing under § 2.1207 or a written hearing under § 2.1208... 10 Energy 1 2010-01-01 2010-01-01 false Findings of fact and conclusions of law. 2.1209 Section...

  5. Leptin, IL-6, and suPAR reflect distinct inflammatory changes associated with adiposity, lipodystrophy and low muscle mass in HIV-infected patients and controls

    Langkilde, Anne; Petersen, Janne; Henriksen, Jens Henrik;

    2015-01-01

    was significantly positively associated with fat mass index (FMI) and abdominal VAT, but not with lean mass index (LMI). IL-6 was significantly associated with both FMI and VAT, and low LMI. High suPAR was associated with low LMI, and weakly with high FMI and VAT. CONCLUSIONS: Leptin reflected...

  6. OXYDATION DU CYCLOHEXANE PAR COMPLEXE DE RUTHÉNIUM

    HAMOUDI, Badreddine

    2008-01-01

    Le complexe RuCl2(PPh3)3 a été préparé dans le but de son application sur la réaction d’oxydation du cyclohexane en cyclhexanol et cyclohexanone. Les analyses par chromatographie en phase gaz sur la phase organique montrent la production de l’alcool et la cétone dans le cas du t-BuOOH comme oxydant, ce qui n’est le cas avec l’eau oxygénée et l’oxygène moléculaire. La réaction a été effectuée dans différents solvants, où l’eau a apportée une meilleure conversion par rapport a...

  7. CFD Application to Hydrogen Risk Analysis and PAR Qualification

    Jinbiao Xiong

    2009-01-01

    Full Text Available A three dimensional computation fluid dynamics (CFD code, GASFLOW, is applied to analyze the hydrogen risk for Qinshan-II nuclear power plant (NPP. In this paper, the effect of spray modes on hydrogen risk in the containment during a large break loss of coolant accident (LBLOCA is analyzed by selecting three different spray strategies, that is, without spray, with direct spray and with both direct and recirculation spray. A strong effect of spray modes on hydrogen distribution is observed. However, the efficiency of the passive auto-catalytic recombiners (PAR is not substantially affected by spray modes. The hydrogen risk is significantly increased by the direct spray, while the recirculation spray has minor effect on it. In order to simulate more precisely the processes involved in the PAR operation, a new PAR model is developed using CFD approach. The validation shows that the results obtained by the model agree well with the experimental results.

  8. Dental Caries Prevalence in the Children of the District of Mosqueiro in the City of Belém, State of Pará, Brazil

    Helder Henrique Costa PINHEIRO

    2006-04-01

    Full Text Available Objective: The study had the objective to check the dental caries prevalence in the children attend by the communitarian agents of health of the Program Health of the Family of the District of Mosqueiro, City of Belém, State of Pará, Brazil, with the purpose of subsidizing the projection of the actions of promotion, prevention and treatment of the staff of oral health. Method: 887 children were examined in the age groups from 18 to 36 months, 5 years and 12 years of age in accordance with the standards recommended by the WHO, checking the events of the caries in the studied population. Results: The caries prevalence in the population of the district of Mosqueiro to 18-36 months of age was 31.68%, progressing in spite of passing the ages, brought near attacking 63.69% of the 12-year-old children. The decayed, to be extracted, filled index (DEF index to five years found in Mosqueiro went of 3.57 and the decayed, missing, filled index (DMF index to 12 years went of 1,80. Regarding the marks proposed by the World Health Organization for the year of 2000, the reached only one was in the age of 12-year-old children, in which the DMF index of 1,80 was less than three. Conclusion: The caries prevalence in the population of Mosqueiro is due to implement effective actions for the control of the disease in this territory.

  9. La relecture du romancero par les vihuelistes de la Renaissance

    Pascal Martel

    1999-01-01

    d’un texte poétique implique donc de la part du compositeur une certaine lecture interprétative du texte puisqu’il privilégie certains éléments de celui-ci pour les traduire, ou pour les amplifier parfois, par la mélodie qu’il leur attribuera.Spanish romances, at the time of the Reconquista, used to tell about past events in the epic mode, on a melodious rhythm which made it easier for the minstrel to store up long narratives in his memory. When Diego Pisador took up a romance, he merely kept a few lines from it. As a result, there is a closer relationship between the words and the notes. On the basis of an epic poem, he made a genuine musical composition through lyrical amplification. He brought about a real aesthetic change, passing from the long narrative based on a short recurrent musical theme, which characterized the medieval romance of the Reconquista, onto a shorter and more elaborate form which blends lyrical vibration and epic contents. As a member of the Royal Court, he intended to serve Felipe II’s interests, and dedicated his work to him. As a vihuelist composer, Pisador contributed to the Moor’s integration, in accordance with the policy which was being implemented by the House of Austria. But the wedding did not take place, and the Moors were expelled in 1609. An analysis of the song clearly reveals how the musician could provide real lyrical amplification to a simple tale through music. The new piece does not simply put music on a poetical text, the music does not simple parallel words, it is not only the musical image of a text. The music and the poem are two autonomous means of expression which, within the song, aim at the same objective. Sometimes they get very close to each other, at other times, each of them follows its own free movement, so that the song is precisely characterized by the permanent tension between its two components. Thus, setting poetry to music implies a certain degree of interpretation on the part of the

  10. Terapia Miofuncional en pacientes con parálisis cerebral

    Gónzalez Amigo, José

    2015-01-01

    En el presente trabajo, se va a llevar a cabo una visión de la parálisis cerebral desde el punto de vista de la motricidad. La parálisis cerebral es una patología que se caracteriza fundamentalmente por una alteración a nivel motriz, que puede afectar a las diferentes extremidades así como a los órganos involucrados en el habla. Estas limitaciones en la región orofacial pueden producir importantes distorsiones y como consecuencia el discurso puede resultar ininteligible para los interlocutore...

  11. La parálisis cerebral en el cine

    Merino Marcos, María Lucila

    2005-01-01

    [ES] En los últimos veinticinco años se han rodado un número importante de películas en las que el protagonista o algún personaje secundario presentaban o simulaban una parálisis cerebral. Estos personajes en ocasiones han sido interpretados por personas con minusvalías. En la narración de su historia las cintas han incluido diversos aspectos sanitario-asistenciales, sociales y familiares obligados en el campo de la parálisis cerebral. [EN] In the last twenty-five years, a number of import...

  12. Apprentissage par Renforcement Développemental en Robotique Autonome

    Sarzyniec, Luc; Buffet, Olivier; Dutech, Alain

    2011-01-01

    National audience Cet article présente une approche développementale de l'apprentissage par renforcement dans un cadre de robotique autonome. Le but est de permettre au robot de tirer parti de la richesse de son environnement sans que cette richesse ne le noie sous trop d'information à traiter. L'idée principale testée ici est de faire croître les capacités perceptives et motrices de l'agent au fur et à mesure de l'apprentissage. Cette approche est combinée avec un apprentissage par renfor...

  13. Ejercicios activos en la parálisis facial

    Bohoyo Aramburu, Cristina

    2013-01-01

    Diseño: Se trata de una revisión bibliográfica en la que se incluyen revisiones sistemáticas y artículos sobre el tratamiento de la parálisis facial mediante ejercicios faciales, que en su conjunto engloban lo que se denomina la “mímicoterapia”. Objetivos: el objetivo principal es determinar la eficacia de los ejercicios faciales activos en el tratamiento de la parálisis de Bell. El objetivo secundario es describir dichos ejercicios. Métodos: se ha realizado una búsqueda mediante la base d...

  14. Cyclanthaceae no estado do Pará, Brasil Cyclanthaceae in Pará State, Brazil

    Eduardo da Silva Leal

    2012-12-01

    Full Text Available Cyclanthaceae apresenta distribuição exclusiva na região neotropical sendo bem diversificada nas terras baixas das florestas pluviais tropicais, ocorrendo do sul do México até a Mata Atlântica do sul do Brasil. Consistem de ervas terrestres, epífitas, hemiepífitas ou lianas. O tratamento taxonômico de Cyclanthaceae no Pará foi baseado em coleções de herbário, trabalhos de campo e consulta a bibliografia referente à família. Foram registradas 11 espécies: Asplundia altiscandens E.S. Leal, A. fanshawei (Maguire Harling, A. glandulosa (Gleason Harling, A. heteranthera Harling, A. latifrons (Drude Harling, A. schizotepala Harling, A. xiphophylla Harling, Cyclanthus bipartitus Poit. ex A. Rich., Evodianthus funifer (Poit. Lindm., Ludovia lancifolia Brongn. e Thoracocarpus bissectus (Vell. Harling. São apresentadas chave de identificação, descrições e ilustrações das espécies, além de comentários sobre distribuição geográfica, hábitat e período de floração e frutificação.Cyclanthaceae is a family with a distribution exclusively in the Neotropics and is well diversified in lowland rainforests, occurring from southern Mexico to the Atlantic Forest of southern Brazil. The family consists of terrestrial herbs, epiphytes, hemiepiphytes and lianas. This taxonomic treatment of the Cyclanthaceae from the state of Pará was based on herbarium specimens, fieldwork, and the literature. Eleven species were recorded: Asplundia altiscandens E.S. Leal, A. fanshawei (Maguire Harling, A. glandulosa (Gleason Harling, A. heteranthera Harling, A. latifrons (Drude Harling, A. schizotepala Harling, A. xiphophylla Harling, Cyclanthus bipartitus Poit. ex A. Rich., Evodianthus funifer (Poit. Lindm., Ludovia lancifolia Brongn. and Thoracocarpus bissectus (Vell. Harling. An identification key, descriptions and illustrations of species are presented. Additional information on the geographic distribution, habitat, and flowering and

  15. Random generation of RNA secondary structures according to native distributions

    Nebel Markus E

    2011-10-01

    Full Text Available Abstract Background Random biological sequences are a topic of great interest in genome analysis since, according to a powerful paradigm, they represent the background noise from which the actual biological information must differentiate. Accordingly, the generation of random sequences has been investigated for a long time. Similarly, random object of a more complicated structure like RNA molecules or proteins are of interest. Results In this article, we present a new general framework for deriving algorithms for the non-uniform random generation of combinatorial objects according to the encoding and probability distribution implied by a stochastic context-free grammar. Briefly, the framework extends on the well-known recursive method for (uniform random generation and uses the popular framework of admissible specifications of combinatorial classes, introducing weighted combinatorial classes to allow for the non-uniform generation by means of unranking. This framework is used to derive an algorithm for the generation of RNA secondary structures of a given fixed size. We address the random generation of these structures according to a realistic distribution obtained from real-life data by using a very detailed context-free grammar (that models the class of RNA secondary structures by distinguishing between all known motifs in RNA structure. Compared to well-known sampling approaches used in several structure prediction tools (such as SFold ours has two major advantages: Firstly, after a preprocessing step in time O(n2 for the computation of all weighted class sizes needed, with our approach a set of m random secondary structures of a given structure size n can be computed in worst-case time complexity Om⋅n⋅ log(n while other algorithms typically have a runtime in O(m⋅n2. Secondly, our approach works with integer arithmetic only which is faster and saves us from all the discomforting details of using floating point arithmetic with

  16. 人类前列腺凋亡反应因子4基因真核表达载体的构建及其在K562细胞中的表达%Construction of human Par-4 eukaryotic expression vector and expression in K562 cells

    秦洁; 王宏伟; 杨涛; 朱镭; 张丽

    2009-01-01

    目的 构建带有绿色荧光蛋白的人类前列腺凋亡反应因子4(Par-4)基因真核表达载体pIRES2-EGFP/Par-4,并转染K562细胞.方法 以pDNR/Par-4质粒为模板,PCR扩增Par-4基因,T-A克隆,亚克隆至pIRES2-EGFP上,并对重组表达载体进行酶切、测序鉴定.采用Superfect转染试剂转染K562细胞.提取细胞总蛋白,Western blotting柃测Par-4表达.结果 经限制性酶切鉴定及测序分析证实pIRES2-EGFP/Par-4载体序列止确;荧光显微镜下可见转染的K562细胞有绿色荧光蛋白的表达,Western blotting 证实转染细胞中存在Par-4蛋白的表达.结论 pIRES2-EGFP/Par-4表达载体构建成功,并在K562细胞内成功表达.%Objective To construct an eukaryotic expression vector of human Par-4 gene with green fluorescent protein gene which iS named pIRES2-EGFP/Par-4 and transfect jt into K562 cell line. Methods Using pDNR/Par-4 plasmid as a template.the full length Par-4 cDNA was amplified by PCR and subsequently cloned into T-A vector.Then subcloned into pIRES2-EGFP vector.After identified by digestion of restriefive endonucleases.pIRES2-EGFP/Par-4 was further confirmed by sequencing.Then it was transfected into K562 cells with Superfect reagents.The total proteins were isolated and Par-4 was detected by Western blotting. Results The exact sequences of pIRES2-EGFP/Par-4 vector were confirmed by digestion of restrictive endonucleases and sequencing.After transfection,the expressions of green fluorescent protein were present.The protein expression of Par-4 has been detected in transfected ceils hv Western blotting.Conclusion The vector pIRES2-EGFP/Par-4 has been constructed and could Successfully express Par-4 gene in K562 cells.

  17. uPAR Targeted Radionuclide Therapy with 177Lu-DOTA-AE105 Inhibits Dissemination of Metastatic Prostate Cancer

    Persson, Morten; Juhl, Karina; Rasmussen, Palle;

    2014-01-01

    value of 100 nM in a competitive binding experiment. In vivo, uPAR targeted radionuclide therapy significantly reduced the number of metastatic lesions in the disseminated metastatic prostate cancer model, when compared to vehicle and nontargeted 177Lu groups (p bioluminescence imaging...... with bioluminescence imaging in a cohort of animals during the treatment study. In conclusion, uPAR targeted radiotherapy resulted in a significant reduction in the number of metastatic lesions in a human metastatic prostate cancer model. Furthermore, we have provided the first evidence of the potential...

  18. Problemes methodologiques poses par l'extraction et la recuperation des bacteries telluriques pour leur quantification par immunofluorescence

    Crozat, Y.; Cleyet-Marel, Jean Claude

    1984-01-01

    Afin d’améliorer la valeur quantitative de la technique de dénombrement des bactéries telluriques (Rhizobium japonicum) par immunofluorescence, on compare différents modes d’extraction et de récupération. L’utilisation de membranes en polycarbonates (Nucléopores) supprime les 40 p. 100 de pertes occasionnées par les membranes cellulosiques (Millipores) classiquement employées. Parmi les différents floculants testés, Ca(OH)2/MgCO3(2/5) permet d’obtenir les meilleurs résultats. Cependant po...

  19. Limitation des populations de ravageurs de l’olivier par le recours à la lutte biologique par conservation

    Warlop, Francois

    2006-01-01

    L’olivier est une culture relativement rustique, mais qui peut être fortement attaquée par la mouche Bactrocera oleae (Gmelin), son principal ravageur. Les parasitoïdes de cette mouche sont connus, mais leur impact sur les populations de Diptères demeure faible, faute d’aménagement adéquat du paysage et suite à une intensification abusive des pratiques culturales. Le programme d’installation de bandes florales mené par le Groupe de recherches en agriculture biologique qui a débuté en 2004 vis...

  20. IGF-II receptors in luminal and basolateral membranes isolated from pars convoluta and pars recta of rabbit proximal tubule

    Jacobsen, Christian; Jessen, H; Flyvbjerg, A

    1995-01-01

    The binding of 125I-labeled insulin-like growth factor-II (125I-IGF-II) to luminal and basolateral membrane vesicles isolated from pars convoluta and the straight part (pars recta) of rabbit proximal tubule was investigated. Analyses of the binding data by use of the general stoichiometric binding...... inhibitory effect of beta-galactosidase. Analyses of 125I-IGF-II binding curves in the presence of beta-galactosidase or D-mannose 6-phosphate demonstrated that none of these compounds changed the binding affinity of 125I-IGF-II for the membrane vesicles. The IGF-II/M6P receptor content in the luminal...

  1. Correlation of Mutation Patterns in gyrA and parC Genes in Ureaplasma Urealyticum Isolates with Quinolones Resistance%gyrA和parC基因突变与解脲支原体喹诺酮类药物耐药相关性研究

    王春燕; 杜江; 吴森林; 孙爱华

    2012-01-01

    Objective To analyze mutations in the quinolone -resistance - determining - region ( QRDR) within genes of gyrA and parC patterns in gyrA and parC genes and quinolones resistance in ureaplasma urealyticum(Uu) isolates. Methods Mycoplasma detection kits were used to culture and identificate mycoplasma as well as drug sensitivity. PCR and DNA sequencing were conducted to analyze QRDR associated genes of gyrA and parC in 42 isolates. Results Only 1 isolate susceptible to all quinolones. Fourty - one isolates showed varying degree resistance to at least one kind of quinolones. Sequencing analysis of gyrA and parC revealed that the susceptible i-solate and 1 resistance isolate had no mutation, Fourty resistance isolates had mutation of D112E and/or S83L in GyrA and ParC. Conclusion Three quinolones should not be routine therapy for ureaplasma urealyticum infections. Mutations in gyrA and parC genes play an important role in the development of quinolones resistance in ureaplasma urealyticum.%目的 探讨解脲支原体gyrA和parC基因喹诺酮耐药决定区(QRDR)突变与喹诺酮类药物耐药的相关性.方法 用支原体培养、鉴定和药敏一体化试剂盒分离获得42株解脲支原体并检测对3种喹诺酮类药物的耐药性,同时PCR法扩增临床分离株的gyrA和parC基因喹诺酮耐药决定区并进行测序分析.结果 对3种喹诺酮均敏感1株,41株至少对1种药物呈现不同程度耐药.gyrA和parC基因喹诺酮耐药决定区测序发现上述敏感株和1株耐药株不发生突变,其余40株耐药株gyrA和parC基因发生D112E和(或)S83L突变.结论 3种喹诺酮类药物耐药均较严重,已不适合作为临床推荐用药,解脲支原体gyrA和parC基因喹诺酮耐药决定区突变与耐药密切相关.

  2. Réduction de l'oxyde d'azote par la suie dans les produits de combustion Reduction of Nitric Oxyde by Soot in Combustion Products

    De Soete G.

    2006-11-01

    Full Text Available On a étudié dans un réacteur à lit fixe la réduction du NO par de la suie formée dans des flammes riches de mélanges éthane/oxygène/argon. Le mélange gazeux traversant le réacteur est de l'argon dopé avec du NO; dans certains cas ce mélange est enrichi d'hydrogène ou d'oxyde de carbone. En présence d'hydrogène ou d'oxyde de carbone, ces vitesses sont nettement plus grandes qu'avec la suie seule. La comparaison avec des vitesses réactionnelles obtenues sur des lits fixes composés d'autres matériaux solides, tels que l'alumine, montre que la réduction de l'oxyde d'azote se fait principalement par une réaction hétérogène avec l'hydrogène et l'oxyde de carbone catalysée par la suie. D'autres matériaux solides,tels que des oxydes réfractaires présentent une activité catalylique aussi importante que la suie. Cette observation fournit une nouvelle explication de l'effet connu de certains additifs sur la réduction de NO dans les flammes. Dans la seconde partie de l'étude, on mesure la réduction des oxydes d'azote dans les flammes fuligineuses de prémélange. De l'argon dopé par de l'oxyde d'azote est injecté dans les produits de combustion de ces flammes chargés de suie; l'introduction du NO est faite à différentes distances derrière le brûleur, correspondant à différents niveaux de température des produits de combustion. La réduction fractionnelle des oxydes d'azote est mesurée en fonction de la concentration en suie, en hydrogène et en oxyde de carbone, en faisant varier la composition du mélange inflammable. Les résultats expérimentaux sont en bon accord avec la réduction calculée en se basant sur les informations cinétiques obtenues en lit fixe. The kinetics of nitric oxide réduction by soot collected from hydrocarbon flames is studied in a fixed-bed reactor. The gas flow traversing thé reactor is either argon with NO, or argon with hydrogen and NO, or argon with carbon monoxide and NO. In th

  3. PH motifs in PAR1&2 endow breast cancer growth.

    Kancharla, A; Maoz, M; Jaber, M; Agranovich, D; Peretz, T; Grisaru-Granovsky, S; Uziely, B; Bar-Shavit, R

    2015-01-01

    Although emerging roles of protease-activated receptor1&2 (PAR1&2) in cancer are recognized, their underlying signalling events are poorly understood. Here we show signal-binding motifs in PAR1&2 that are critical for breast cancer growth. This occurs via the association of the pleckstrin homology (PH) domain with Akt/PKB as a key signalling event of PARs. Other PH-domain signal-proteins such as Etk/Bmx and Vav3 also associate with PAR1 and PAR2 through their PH domains. PAR1 and PAR2 bind with priority to Etk/Bmx. A point mutation in PAR2, H349A, but not in R352A, abrogates PH-protein association and is sufficient to markedly reduce PAR2-instigated breast tumour growth in vivo and placental extravillous trophoblast (EVT) invasion in vitro. Similarly, the PAR1 mutant hPar1-7A, which is unable to bind the PH domain, reduces mammary tumours and EVT invasion, endowing these motifs with physiological significance and underscoring the importance of these previously unknown PAR1 and PAR2 PH-domain-binding motifs in both pathological and physiological invasion processes. PMID:26600192

  4. Par Pond vegetation status summer 1995 - July survey descriptive summary

    A survey of the emergent shoreline aquatic plant, communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet (61 meters) above mean sea level, and continued with this July survey. Aquatic plant communities, similar to the pre-drawdown Par Pond communities, are becoming reestablished. Beds of maidencane (Panicum hemitomon), lotus (Nelumbo lutea), water lily (Nymphaea odorata), and watershield (Brasenia schreberi) are now extensive and well established. In addition, within isolated coves, extensive beds of water lilies and spike-rush (Eleocharis sp.) are common. Cattail occurrence has increased since refill, but large beds common to Par Pond prior to the drawdown have not formed. Invasion of willow (Salix sp.) and red maple (Acer rubrum) occurred along the lake shoreline during drawdown. The red maples along the present shoreline are beginning to show evidence of stress and mortality from flooding over the past four months. Some of the willows appear to be stressed as well. The loblolly pines (Pinus taeda), which were flooded in all but the shallow shoreline areas, are now dead. Future surveys are planned for the growing seasons of 1995, 1996, and 1997, along with the evaluation of satellite data for mapping the areal extent of the macrophyte beds of Par Pond

  5. Radiative Transfer Code: Application to the calculation of PAR

    D Emmanuel; D Phillippe; C Malik

    2000-12-01

    The production of carbon in the ocean, the so-called primary production, depends on various physico- biological parameters: the biomass and nutrient amounts in oceans, the salinity and temperature of the water and the light available in the water column. We focus on the visible spectrum of the solar radiation defined as the Photosynthetically Active Radiation (PAR). We developed a model (Chami et al. 1997) to simulate the behavior of the solar beam in the atmosphere and the ocean. We first describe the theoretical basis of the code and the method we used to solve the radiative transfer equation (RTE): the successive orders of scattering (SO). The second part deals with a sensitivity study of the PAR just above and below the sea surface for various atmospheric conditions. In a cloudy sky, we computed a ratio between vector fluxes just above the sea surface and spherical fluxes just beneath the sea surface. When the optical thickness of the cloud increases this ratio remains constant and around 1.29. This parameter is convenient to convert vector flux at the sea surface as retrieved from satellite to PAR. Subsequently, we show how solar radiation as vector flux rather than PAR leads to an underestimate of the primary production up to 40% for extreme cases.

  6. uPAR as anti-cancer target

    Lund, Ida K; Illemann, Martin; Thurison, Tine;

    2011-01-01

    Degradation of proteins in the extracellular matrix is crucial for the multistep process of cancer invasion and metastasis. Compelling evidence has demonstrated the urokinase receptor (uPAR) and its cognate ligand, the urokinase plasminogen activator (uPA), to play critical roles in the concerted...

  7. Radiological impact of Par Pond drawdown from liquid effluent pathways

    The water level of Par Pond has been lowered over the past several months to reduce the effects in the event of catastrophic dam failure while assessing the condition of the dam and determining if repairs are necessary. In lowering the level of Par Pond, 60 billion liters of water containing low levels of tritium and cesium-137 were discharged to several onsite streams. SRS surface streams flow to the Savannah River. An assessment made to determine the total amount of tritium and Cs-137 discharged and to estimate the consequences to downstream Savannah River users. It is estimated that a total of 160 curies of tritium were displaced from Par Pond to the Savannah River between June 28, 1991 and September 19, 1991. This release could hypothetically result in a maximum individual dose of 3. 2x10-4 mrem and a total (80-km and drinking water populations) population dose of 1.4x10-2 person-rem. Likewise, a maximum individual dose of 5.0x10-2 mrem and a total population dose of 1.7x10-1 person- rem are predicted as a result of an estimated 0.21 curies of Cs-137 being discharged from Par Pond to the Savannah River

  8. Pollution par les nitrates: quels remèdes?

    Zilliox, Lothaire; Schenck, Charles; Kobus, Helmut; Huwe, Bernd

    1990-01-01

    Au cours des dix dernières années, la pollution des eaux souterraines par les nitrates n'a cessé d'augmenter. Principale accussée: l'agriculture, l'application de méthodes de techniques culturales devrait permettre une meilleure gestion des engrais azotés.

  9. La lecture de Merleau-Ponty par Renaud Barbaras

    Pechar, Jiří

    2015-01-01

    Roč. 11, č. 2 (2015). ISSN 1336-6556 Institutional support: RVO:67985955 Keywords : Merleau-Ponty * Husserl * phenomenology * linguistics of Ferdinand de Saussure Subject RIV: AA - Philosophy ; Religion http://www.ostium.sk/sk/la-lecture-de-merleau-ponty-par-renaud-barbaras/

  10. Den eneste ene - hvordan etniske minoritetsunge i Danmark danner par

    Singla, Rashmi

    Rapporten handler om etniske unges måde at danne par på. Rapporten er baseret på en større empirisk undersøgelse gennemført af forfatteren i 2003 og er desuden inspireret af forfatterens egen ph.d.-afhandling: "Ungdom, etnicitet og psychosocial intervention" (2000, Københavns Universitet). Rappor...

  11. Predicting spectral and PAR light attenuation in Greenlandic coastal waters

    Murray, Ciarán; Markager, Stiig; Stedmon, Colin

    present models for spectral and PAR (photosynthetically active radiation) attenuation in two contrasting Greenlandic fjords, Godthåbsfjord (SW Greenland) and Young Sound (NE Greenland). The fjords differ in the character and concentrations of optically active components present: dissolved organic material...

  12. Development of quantitative RT-PCR assays for wild-type urokinase receptor (uPAR-wt) and its splice variant uPAR-del5

    The receptor for the serine protease urokinase-type plasminogen activator, uPAR (CD 87), plays an important role in tumor cell invasion and metastasis of solid malignant tumors. uPAR is a highly glycosylated, glycan lipid-anchored membrane protein, consisting of three homologous domains. Each individual domain is encoded by two exons: DI by exons 2+3, DII by exons 4+5, and DIII by exons 6+7. Beside the wild-type (wt) uPAR mRNA, two splice variants either lacking exon 5 (uPAR-del5) or both exons 4 and 5 (uPARdel4/ 5) have been described. Previously, we studied expression of the mRNA variant uPAR-del4/5 and uPAR mRNA encompassing exons 2, 3, and 4 (i.e. uPAR-wt plus uPAR-del5) applying real-time RT-PCR assays for quantification of the mRNA concentration. In the present paper, we established two additional specific, robust and highly sensitive RT-PCR assays, based on the LightCycler technology, to specifically quantify either uPAR-wt or its splice variant, uPARdel5. Expression of uPAR-wt and uPAR-del5 was analyzed in different human malignant cell lines (ovarian cancer cell lines OVMZ-6 and OVMZ-10; breast cancer cell lines MDA-MB 231, MDA-MB 231 BAG, MDA-MB 435, and aMCF-7; brain tumor cell line LN 18) as well as in a set of 174 breast cancer tissue samples. uPAR-del5 mRNA was found to be expressed very frequently at a rather low level (typically less than 1% of uPAR-wt mRNA). In tumor tissue from breast cancer patients, a statistically significant correlation between uPAR-del5 and uPAR-wt mRNA (r = 0.779; P < 0.001) was observed. There was no association between the expression level of either mRNA and clinical parameters such as nodal status, tumor size and grade. In estrogen receptor negative tumors, a significantly higher uPAR-del5 expression was found (P 0.023). The two developed quantitative RT-PCR assays described here may aid further analysis of the function and clinical relevance of uPAR-wt and one of its splice variants, uPAR-del5, in malignant tumors

  13. Conclusive Teleportation of an Arbitrary Three-Particle State via Positive Operator-Valued Measurement

    We present a scheme for conclusive teleportation of an arbitrary and unknown three-particle state by performing three Bell-state measurements at the sender's side and a positive operator-valued measurement at the receiver's side. Moreover, we obtain the successful probability of teleportation and make a brief discussion on the average fidelity for the conclusive teleportation scheme

  14. Imouraren mining exploitation : Complementary studies Synthetics report volume A. Summary and conclusions

    The document presents the summary and conclusions of complementary studies realized during the feasibility study of the Imouraren uranium deposit development.These conclusions consist of mining reserves containing 32200 tonnes of uranium in the concentrate , technical feasibility of the project program realization and profitability

  15. 37 CFR 351.14 - Proposed findings of fact and conclusions of law.

    2010-07-01

    ... conclusions of law. 351.14 Section 351.14 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS COPYRIGHT ROYALTY JUDGES RULES AND PROCEDURES PROCEEDINGS § 351.14 Proposed findings of... conclusions, briefs or memoranda of law, or may be directed by the Copyright Royalty Judges to do so....

  16. La partialité par les projets

    Sarah Stroud

    2008-02-01

    Full Text Available This paper investigates how we can most effectively argue that partiality toward certain people and not others is morally permissible. Philosophers who strongly insist that morality must leave room for partiality have not made explicit their basis for this conclusion; the present paper comparatively assesses a variety of possible argument strategies which could be deployed in this regard. One promising strategy exploits the acknowledged force of the argument from “the personal point of view,” here interpreted as referring specifically to an agent’s projects. If moral demands must be tempered in light of the special significance to an agent of his own projects, then perhaps the agent’s partial attachments to other people should also receive a measure of protection from impartial moral claims. The case is bolstered by noting the ubiquity of plural or collective agency in contexts of close personal relations: often the two (or more agents in such relationships together pursue joint projects and even constitute a plural agent. This approach does justify special moral treatment of one’s co-agents, although it does not match our initial conception of partiality in all respects.

  17. La prise en charge des suicides par précipitation en traumatologie

    Abdelmajid Elmrini

    2010-09-01

    Full Text Available OBJECTIFS: A travers ce travail, l’épidémiologie et la psychopathologie du suicide par précipitation seront rappelées, le rôle du chirurgien traumatologue dans la restauration physique et psychique sera démontré. METHODES: Nous rapportons une étude rétrospective de 15 suicidants par précipitation admis pour des traumatismes complexes de l’appareil locomoteur entre 2004 et 2007. RESULTATS: Il s’agissait de primosuicidants, comprenant 10 femmes et 5 hommes. L’âge moyen des hommes est de 26,5 ans (24-34 ans et celui des femmes de 40,7 ans (17-45 ans. Le bilan lésionnel des suicidants a retrouvé 14 fractures des membres inférieurs, 4 traumatisme du rachis avec compression médullaire dans 1 cas, une fracture du bassin; deux traumatismes du membre supérieur. Aucun de ces patients n’a présenté de lésions viscérales ni de traumatismes crâniofacial. 80% (n = 12 des patients souffraient d’une affection psychiatrique avant leur passage à l’acte suicidaire : 8 pour une pathologie dépressive et 4 pour une schizophrénie. Chaque suicidant a subi au moins un acte chirurgical. Tous les patients avaient poursuivi la prise en charge psychiatrique en ambulatoire. Nos résultats fonctionnels étaient satisfaisants sans complications. Aucun des patients n’a récidivé. La pathologie suicidaire représente un problème de santé publique. Le suicide par précipitation représente 5 % de l’ensemble des modalités suicidaires. Les traumatismes occasionnés par ce mode suicidaire sont complexes et graves. Leur prise en charge nécessite une collaboration multidisciplinaire. CONCLUSION: La réparation chirurgicale permet à la fois le rétablissement de la fonction et l’amélioration psychique du sujet prévenant contre une rechute dépressive ou une récidive suicidaire.

  18. Nutritional profile of the HIPERDIA Program users in Ananindeua, Pará state, Brazil

    Bruna Ranyelle de Marinho Sousa

    2013-07-01

    Full Text Available Objective: To investigate the nutritional profile and understand the dietary habits of patients in the HIPERDIA Program aiming to contribute to the discussion on disease prevention and health promotion in primary care. Methods: From August 2011 to February 2012, students and tutors of the “Programa de Educação pelo Trabalho para a Saúde” (PET-Saúde of the Federal University of Pará interviewed 125 individuals with hypertension and/ or diabetes registered in the Family Health Strategy of “Jardim Florestal” and “Mururé” in the municipality of Ananindeua, Pará state. We applied a structured questionnaire containing questions about socio-economic profile, clinical data, habits, and life style related to patients’ food consumption. Results: Among the respondents, 65.6% were diabetics and 84.8% were hypertensive. Most of the respondents (81.6% claimed that they had been following a diet to control hypertension or diabetes mellitus, especially with regard to salt, fat, and sugar reduction. Overweight (BMI greater than 24.9 kg/m² was a predominant factor in the population analyzed (73.6% of the respondents. Conclusion: The research participants were not following an adequate diet requirement. In this context, it is necessary to improve nutritional monitoring and implement socio-educational preventive measures in order to control chronic non-transmissible diseases, thus ameliorating people’s quality of life.

  19. Detection of suPAR in the Saliva of Healthy Young Adults: Comparison with Plasma Levels

    Anna Gustafsson; Vjosa Ajeti; Lennart Ljunggren

    2011-01-01

    The soluble urokinase plasminogen activator receptor (suPAR) has been detected in blood, plasma, serum, urine, ovarian cystic fluid, and cerebrospinal fluid. Elevated suPAR levels in plasma have been associated with negative outcomes in various diseases, such as bacteremia, sepsis, SIRS, cardiovascular disease, cancer, and tuberculosis. The primary aim of this study was to investigate whether suPAR can be detected in saliva from healthy individuals and thus, if saliva suPAR can be related to ...

  20. Conclusions of the presidency. European council of Barcelona, March 15 and 16 2002; Conclusions de la presidence. Conseil europeen de Barcelone 15 et 16 mars 2002

    NONE

    2002-07-01

    This document summarizes the conclusions of the European Council held in Barcelona (Spain) on March 15 and 16, 2002. Among the priority actions listed by the council figure the integration of energy, transportation and communication networks at the European scale. In particular, the council commits the Parliament and itself to start the final phase of opening of gas and electricity markets: free choice of a supplier, obligation of public utility, security of supplies, separation between transmission and distribution and between production and supply, non-discriminatory access of consumers and suppliers to networks with transparent tariffs, establishment of a regulatory agency in each member state, agreement for a tariffing system for the international electricity trades etc.. Concerning the sustainable development strategy of the European union, the council is pressing the member states for the completion of the national procedures of ratification of the Kyoto protocol. However, new measures need to be taken to develop technologies respectful for the environment, in particular in the domain of energy and transports. (J.S.)

  1. Inappropriate statistical method in a parallel-group randomized controlled trial results in unsubstantiated conclusions.

    Dimova, Rositsa B; Allison, David B

    2016-01-01

    The conclusions of Cassani et al. in the January 2015 issue of Nutrition Journal (doi: 10.1186/1475-2891-14-5 ) cannot be substantiated by the analysis reported nor by the data themselves. The authors ascribed the observed decrease in inflammatory markers to the components of flaxseed and based their conclusions on within-group comparisons made between the final and the baseline measurements separately in each arm of the randomized controlled trial. However, this is an improper approach and the conclusions of the paper are invalid. A correct analysis of the data shows no such effects. PMID:27265269

  2. Talking about man's knowledge of the structure of matter. Conclusion

    Ho, T.

    1977-03-01

    The term elementary particle is inaccurate because it implies that there is some irreducible building block of matter. A better term would be field particle, that is, particles of quantum fields. In accord with both quantum field theory and dialectical materialism, field particles and all matter are infinitely divisible.

  3. Preliminary Conclusions after the Design and Implementation of Mobile Learning Apps for Professionals

    Castrillo, María Dolores; Bárcena, Elena; Pareja-Lora, Antonio

    2014-01-01

    According to a recent research carried out by Aruba Networks (2014) in the US, the UK, France, Spain, Germany, Sweden, South Africa, Saudi Arabia and UAE, 86% of all respondents have two or more devices that can connect to the internet, and nearly two thirds (64%) already own three or more mobile devices with this feature; another 39% own four or…

  4. Detection of suPAR in the Saliva of Healthy Young Adults: Comparison with Plasma Levels

    Gustafsson, Anna; Ajeti, Vjosa; Ljunggren, Lennart

    2011-01-01

    The soluble urokinase plasminogen activator receptor (suPAR) has been detected in blood, plasma, serum, urine, ovarian cystic fluid, and cerebrospinal fluid. Elevated suPAR levels in plasma have been associated with negative outcomes in various diseases, such as bacteremia, sepsis, SIRS, cardiovascular disease, cancer, and tuberculosis. The primary aim of this study was to investigate whether suPAR can be detected in saliva from healthy individuals and thus, if saliva suPAR can be related to plasma suPAR, CRP, BMI, or gender. Blood and unstimulated whole saliva was collected from 20 healthy individuals (10 female and 10 male, median age of 28 years; range 21–41). CRP and suPAR were measured with ELISA in saliva and serum/plasma. suPAR was detected in all saliva samples in the 5.2–28.1 ng/mL range, with a median value of 17.1 ng/mL. Saliva suPAR was significantly higher (P < 0.001) but not correlated to plasma suPAR in healthy young adults with normal plasma suPAR levels. suPAR and CRP levels were correlated in blood but not in saliva. No correlation was found between BMI, age, or gender and suPAR in saliva. PMID:22084570

  5. Intact and cleaved uPAR forms: diagnostic and prognostic value in cancer

    Rasch, M.G.; Lund, I.K.; Hoyer-Hansen, G.;

    2008-01-01

    identified in tissue and body fluids. It is well-established, that the total amount of all uPAR forms is a strong prognostic marker in different types of cancer. Using immunoassays, measuring the individual uPAR forms, has revealed that the cleaved uPAR forms are even stronger prognostic markers and have...

  6. ParA resolvase catalyzes site-specific excision of DNA from the Arabidopsis genome

    The small serine resolvase ParA from bacterial plasmids RK2 and RP4 catalyzes the recombination of two identical 133 bp recombination sites known as MRS. Previously, we reported that ParA is active in the fission yeast Schizosaccharomyces pombe. In this work, the parA recombinase gene was placed un...

  7. The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi

    J.W.R. Hovius; M.F. Bijlsma; G.J.W. van der Windt; W.J. Wiersinga; B.J.D. Boukens; J. Coumou; A. Oei; R. de Beer; A.F. de Vos; C. van 't Veer; A.P. van Dam; P. Wang; E. Fikrig; M.M. Levi; J.J.T.H. Roelofs; T. van der Poll

    2009-01-01

    The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can also

  8. First (18)F-labeled ligand for PET imaging of uPAR

    Persson, Morten; Liu, Hongguang; Madsen, Jacob;

    2013-01-01

    Urokinase-type plasminogen activator receptor (uPAR) is overexpressed in human prostate cancer and uPAR has been found to be associated with metastatic disease and poor prognosis. AE105 is a small linear peptide with high binding affinity to uPAR. We synthesized an N-terminal NOTA...

  9. Is There an "F" in Your PAR? Understanding, Teaching and Doing Action Research

    Lorenzetti, Liza; Walsh, Christine Ann

    2014-01-01

    Participatory Action Research (PAR) is increasingly recognized within academic research and pedagogy. What are the benefits of including feminism within participatory action research and teaching? In responding to this question, we discuss the similarities and salient differences between PAR and feminist informed PAR (FPAR). There are eight themes…

  10. Bacterial mitosis: partitioning protein ParA oscillates in spiral-shaped structures and positions plasmids at mid-cell

    Ebersbach, Gitte; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2004-01-01

    with a single plasmid focus, the focus located preferentially at mid-cell. In cells with two foci, these located at quarter-cell positions. In the absence of ParB and parC1/parC2, ParA-GFP formed stationary helices extending from one end of the nucleoid to the other. In the presence of ParB and parC1/parC2, ParA-GFP......The par2 locus of Escherichia coli plasmid pB171 encodes oscillating ATPase ParA, DNA binding protein ParB and two cis-acting DNA regions to which ParB binds (parC1 and parC2). Three independent techniques were used to investigate the subcellular localization of plasmids carrying par2. In cells...... oscillated in spiral-shaped structures. Amino acid substitutions in ParA simultaneously abolished ParA spiral formation, oscillation and either plasmid localization or plasmid separation at mid-cell. Therefore, our results suggest that ParA spirals position plasmids at the middle of the bacterial nucleoid...

  11. Conclusion on the peer review of the pesticide risk assessment of the active substance ferric phosphate

    European Food Safety Authority

    2015-01-01

    The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State Germany, for the pesticide active substance ferric phosphate are reported. The context of the peer review was that required by Commission Regulation (EU) No 1141/2010 as amended by Commission Implementing Regulation (EU) No 380/2013. The conclusions were reached on the basis of the evaluation of the represe...

  12. Conclusion on the peer review of the pesticide risk assessment of the active substance penflufen

    European Food Safety Authority

    2012-01-01

    The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State the United Kingdom, for the pesticide active substance penflufen are reported. The context of the peer review was that required by Commission Regulation (EU) No 188/2011. The conclusions were reached on the basis of the evaluation of the representative use of penflufen as a fungicide on potatoes. T...

  13. The explicit signalling of premise-conclusion sequences in research articles: a contrastive framework

    Moreno, Ana I

    1998-01-01

    The aim of the present paper is to propose a contrastive framework for a comparison of the explicit signalling of premise-conclusion sequences between English and Spanish. It is argued that in order for contrastive analyses of these kind of phenomena to be valid and useful for applied fields, greater levels of precision are needed than those found in some previous studies. The model first defines the constants of the comparison: explicit premise-conclusion intersentential relations (PQISRs). ...

  14. Conclusion on the peer review of the pesticide risk assessment of the active substance orange oil

    European Food Safety Authority

    2013-01-01

    The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State France, for the pesticide active substance orange oil are reported. The context of the peer review was that required by Commission Regulation (EU) No 188/2011. The conclusions were reached on the basis of the evaluation of the representative use as an insecticide for the control of whitefly larvae and adult...

  15. The valid conclusion of the compromise/transaction contract. Special rules

    Georgeta-Bianca SPÎRCHEZ

    2012-01-01

    In this paper we aimed to examine the legal mechanisms that ensure the protection of the parties within this form of private justice-that of compromise conclusion. For a systematic approach of this subject, we reported, first of all, to the general rules governing, in terms of validity, the conclusion of conventions, but mostly we leaned on the particular aspects relating to this specific contract. In order to respond to the main objectives, we reviewed the legal requirements in force and the...

  16. Audiometric profile of civilian pilots according to noise exposure

    Falcão, Taiana Pacheco; Luiz, Ronir Raggio; Schütz, Gabriel Eduardo; Mello, Márcia Gomide da Silva; Câmara, Volney de Magalhães

    2014-01-01

    OBJECTIVE To evaluate the audiometric profile of civilian pilots according to the noise exposure level. METHODS This observational cross-sectional study evaluated 3,130 male civilian pilots aged between 17 and 59 years. These pilots were subjected to audiometric examinations for obtaining or revalidating the functional capacity certificate in 2011. The degree of hearing loss was classified as normal, suspected noise-induced hearing loss, and no suspected hearing loss with other associated complications. Pure-tone air-conduction audiometry was performed using supra-aural headphones and acoustic stimulus of the pure-tone type, containing tone thresholds of frequencies between 250 Hz and 6,000 Hz. The independent variables were professional categories, length of service, hours of flight, and right or left ear. The dependent variable was pilots with suspected noise-induced hearing loss. The noise exposure level was considered low/medium or high, and the latter involved periods > 5,000 flight hours and > 10 years of flight service. RESULTS A total of 29.3% pilots had suspected noise-induced hearing loss, which was bilateral in 12.8% and predominant in the left ear (23.7%). The number of pilots with suspected hearing loss increased as the noise exposure level increased. CONCLUSIONS Hearing loss in civilian pilots may be associated with noise exposure during the period of service and hours of flight. PMID:25372170

  17. ron Intake in Adults from Medellin According to Demographics, 2012

    Carmen Yulieth Mantilla Gutiérrez

    2014-05-01

    Full Text Available Objectives: To analyze the iron intake in healthy adults of Medellín according to demographics, and to determine the association between the consumption of iron and hemoglobin in this popula¬tion. Materials and methods: Cross-sectional study in 109 subjects. We applied a semiquantitative survey of food consumption frequency source of iron given the frequency of consumption and portion. Summary measures, frequencies, Mann Whitney, Kruskal Wallis ANOVA and Spearman correlation were calculated. We used SPSS version 20.0, considering a significance level of 0.05. Results: The mean age subjects was 32, 64.2 % were female, 81.6 % with technical or university studies, 29.3 % students and 43.9 % of low socioeconomic status. We found a daily intake of 12.3 mg/day on average, 61 % from non-heme iron. The total iron consumed was statistically higher in unemployed subjects than in workers, students and housewives. The heme iron intake was statistically higher in individuals with graduate. No statistically significant differences were observed when comparing iron consumption by sex, age group and hemoglobin. Conclusions: The low intake of iron is not influenced by sex or age group, but by occupation and education, and is a factor that cannot reduce the prevalence of iron and other micronutrients deficiencies. It requires to implement more and better strategies for nutrition education and increased avail¬ability, production and consumption of safe food

  18. Maternal postpartum complications according to delivery mode in twin pregnancies

    Sonia Leme Stach

    2014-07-01

    Full Text Available OBJECTIVE:We aimed to examine maternal postpartum complications of twin deliveries according to mode of delivery and investigate the associated risk factors.METHODS:This was a retrospective cohort review of twin pregnancies with delivery after 26 weeks at a tertiary teaching hospital (1993-2008. The rates of maternal postpartum complications were compared among vaginal, elective cesarean and emergency cesarean deliveries. Significant predictors of complications were investigated with stepwise regression analysis and relative risks were calculated.RESULTS:A total of 90 complications were observed in 56/817 (6.9% deliveries: 7/131 (5.3% vaginal, 10/251 (4.0% elective cesarean and 39/435 (9.0% emergency cesarean deliveries. Significant predictors included high-risk pregnancy, gestational age at birth and delivery mode. The occurrence of complications was significantly increased in emergency compared to elective cesarean deliveries (RR = 2.34.CONCLUSIONS:Maternal postpartum complications in twin pregnancies are higher in emergency compared to elective cesarean deliveries and are also related to preexisting complications and earlier gestational age at delivery.

  19. Downregulation of uPAR and cathepsin B induces apoptosis via regulation of Bcl-2 and Bax and inhibition of the PI3K/Akt pathway in gliomas.

    Ramarao Malla

    Full Text Available BACKGROUND: Glioma is the most commonly diagnosed primary brain tumor and is characterized by invasive and infiltrative behavior. uPAR and cathepsin B are known to be overexpressed in high-grade gliomas and are strongly correlated with invasive cancer phenotypes. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we observed that simultaneous downregulation of uPAR and cathepsin B induces upregulation of some pro-apoptotic genes and suppression of anti-apoptotic genes in human glioma cells. uPAR and cathepsin B (pCU-downregulated cells exhibited decreases in the Bcl-2/Bax ratio and initiated the collapse of mitochondrial membrane potential. We also observed that the broad caspase inhibitor, Z-Asp-2, 6-dichlorobenzoylmethylketone rescued pCU-induced apoptosis in U251 cells but not in 5310 cells. Immunoblot analysis of caspase-9 immunoprecipitates for Apaf-1 showed that uPAR and cathepsin B knockdown activated apoptosome complex formation in U251 cells. Downregulation of uPAR and cathepsin B also retarded nuclear translocation and interfered with DNA binding activity of CREB in both U251 and 5310 cells. Further western blotting analysis demonstrated that downregulation of uPAR and cathepsin B significantly decreased expression of the signaling molecules p-PDGFR-β, p-PI3K and p-Akt. An increase in the number of TUNEL-positive cells, increased Bax expression, and decreased Bcl-2 expression in nude mice brain tumor sections and brain tissue lysates confirm our in vitro results. CONCLUSIONS/SIGNIFICANCE: In conclusion, RNAi-mediated downregulation of uPAR and cathepsin B initiates caspase-dependent mitochondrial apoptosis in U251 cells and caspase-independent mitochondrial apoptosis in 5310 cells. Thus, targeting uPAR and cathepsin B-mediated signaling using siRNA may serve as a novel therapeutic strategy for the treatment of gliomas.

  20. Heterogeneidade do desempenho de alunos da Unicamp, do ingresso à conclusão Heterogeneity in the performance of Unicamp students from admission to conclusion of undergraduated studies

    Rafael Pimentel Maia

    2009-08-01

    Full Text Available O objetivo deste trabalho é propor uma metodologia para avaliar o desempenho dos alunos da Universidade Estadual de Campinas, do ingresso à conclusão do curso. A amostra é composta por todos os ingressantes dessa universidade nos anos de 1997 a 2000, e a população que corresponde ao universo dos alunos ingressantes em todo o período de existência da universidade. O conjunto de dados disponível foi obtido a partir dos questionários socioculturais, aplicados pela Comissão Permanente de Vestibulares na inscrição do vestibular, e de informações acadêmicas fornecidas pela Diretoria Acadêmica da Universidade. É proposta uma metodologia com base na variável denominada "ganho relativo" sugerida por Dachs e Maia (2006. Essa nova metodologia fundamenta-se em medidas de diversidades propostas por Rao (1982 e na utilização de U-estatísticas. Propõem-se testes de homogeneidade para avaliar se existe diferença no desempenho entre alunos segundo alguns agrupamentos.The aim of this work is to propose a methodology to evaluate the performance of students at Unicamp [São Paulo State University at Campinas] from admission to graduation. The sample consists of all students enrolled in Unicamp from 1997 to 2000, and the population corresponds to the universe of students throughout the existence of the university. The available database was gathered from socio-cultural questionnaires applied by the University Commission on College Entrance Examination at the time of enrollment for the examination ("vestibular" and from academic information provided by the Unicamp Academic Studies Board. A methodology is proposed based on the "relative gain" variable suggested by Dachs and Maia (2006. This new methodology is based on the diversity measures proposed by Rao (1982 and on the use of U-statistics. Homogeneity tests have been proposed to assess whether there is a difference in performance among students from different groups.

  1. Des guides touristiques pour le peuple et par le peuple

    Ninon Vinsonneau

    2006-04-01

    Full Text Available Le Federal Writers’ Project (FWP constitua l’un des quatre programmes « culturels » lancés par l’administration du New Deal en 1935 en vue de résorber le problème du chômage parmi les professions dites « en col blanc ». Il employa de 1935 à 1943, entre quatre et six mille chômeurs par an, tous membres des « professions de l’écrit » — les « écrivains », au sens large que l’administration fédérale donnait à ce terme : romanciers, poètes, dramaturges, mais aussi journalistes, enseignants, cherc...

  2. La syphilis congenitale revelee par une fracture spontanee

    Mounia Lakhdar Idrissi

    2011-11-01

    Full Text Available Alors qu�elle est actuellement oubliee dans les pays developpes, la syphilis congenitale se voit encore chez nous faute du depistage antenatal. Ses formes cliniques sont polymorphes et orientent a tord vers d�autres pathologies surtout en periode neonatale. Le diagnostic n�est donc pas toujours facile. La revelation d�une syphilis congenitale par une fracture spontanee est exceptionnellement decrite. Nous rapportons dans ce travail le cas d�un nourrisson de 2 mois ramene en consultation pour limitation douloureuse des mouvements du bras droit. Le diagnostic est evoque sur les donnees radiologiques et confirme par la serologie syphilitique. Le traitement a repose essentiellement sur l�administration de la penicilline G avec une bonne evolution clinique.

  3. Diffusion d'un champ electromagnetique par un batiment modelise

    Bourrely, Claude

    2008-01-01

    Cette étude présente la diffusion d'un champ électromagnétique par un batiment de bureaux modélisé suivant un réseau bipériodique, en particulier, l'objectif est de calculer le champ réfléchi et transmis. Ce champ est produit par une antenne extérieure au batiment, on suppose qu'elle émet une onde plane. On travaille dans un domaine de longueur d'onde qui est inférieur à la plus petite dimension de la structure, ce qui correspond à l'épaisseur des murs. Les calculs sont effectués suivant la m...

  4. Valorisation de biogaz pour industrie chimie par voie catalytique

    Taimoor, Aqeel Ahmad

    2010-01-01

    La production de l'hydrogène à partir de biomasse est actuellement à l'étude mais la méthode de valorisation du biogaz (mélange H2/CO2) par réactions catalytiques, autres que la simple combustion, n'a pas encore été retenue. Par conséquent, le principal objectif de ce travail est d'explorer les autres voies. L'effet du CO2 sur le système catalytique est mal connu et seulement un effet négatif sur la dissociation de l'hydrogène a été mentionné. L'hydrogénation du toluène sur un catalyseur Pt a...

  5. Aplicación de algoritmos de control clásico, adaptable y robusto a sistemas dinámicos de parámetros variables;Classic, adaptable and robust control algorithm application, to variant parameter dynamic system.

    Orlando – Regalón Anias

    2012-11-01

    Full Text Available Existen múltiples sistemas dinámicos cuyos modelos matemáticos se caracterizan por ser de primer orden yparámetros variables con el tiempo. En estos casos las herramientas clásicas no siempre logran un sistema decontrol que sea estable, posea un buen desempeño dinámico y rechace adecuadamente las perturbaciones, cuandoel modelo de la planta se desvía del nominal, para el cual se realizó el diseño.En este trabajo se evalúa elcomportamiento de tres estrategias de control en presencia de variación de parámetros. Estas son: control clásico,control adaptable y control robusto. Se realiza un estudio comparativo de las mismas en cuanto a complejidad deldiseño, costo computacional de la implementación y sensibilidad ante variaciones en los parámetros y/o presencia dedisturbios. Se llega a conclusiones que permiten disponer de criterios para la elección más adecuada, endependencia de los requerimientos dinámicos que la aplicación demande, así como de los medios técnicos de que sedisponga.Many dynamic systems have first order mathematic models, with time variable parameters. In these cases, theclassical tools do not satisfy at all control system stability, good performance and perturbation rejection, when theplant model differs from the nominal one, for which the controller was designed.In this article, three control strategiesare evaluated in parameter variations and disturbance presence. The strategies are the followings: classical control,adaptive control and robust control. A comparative study is carried out, taking into account the design complexity, thecomputational cost and the sensitivity. The obtained conclusions helps to provide the criterion to choose the mostadequate control strategy, according to the necessary dynamic, as well as the available technical means.

  6. L'exraction par micro-ondes: un choix de qualité

    Ramdani, M.; Ghazi, Z.; Fadel, O.; Mouni, L.; Wathelet, Jean-Paul

    2010-01-01

    Le but de ce travail est de comparer l’extraction faite par chauffage classique (CC) avec celle réalisée sous micro-ondes (MO). Deux modes d’extraction ont été réalisés : - L’hydro-distillation par chauffage classique (extraction par entraînement à la vapeur d’un solvant) et, - L’hydro-distillation activée par micro-ondes. Les MO permettent un gain de temps considérable. Par exemple, dans le cas du lavandula dentata : on note une cinétique 3 fois plus rapide, de plus le rendement ...

  7. A fallacious jar? The peculiar relation between descriptive premises and normative conclusions in neuroethics.

    Wagner, Nils-Frederic; Northoff, Georg

    2015-06-01

    Ethical questions have traditionally been approached through conceptual analysis. Inspired by the rapid advance of modern brain imaging techniques, however, some ethical questions appear in a new light. For example, hotly debated trolley dilemmas have recently been studied by psychologists and neuroscientists alike, arguing that their findings can support or debunk moral intuitions that underlie those dilemmas. Resulting from the wedding of philosophy and neuroscience, neuroethics has emerged as a novel interdisciplinary field that aims at drawing conclusive relationships between neuroscientific observations and normative ethics. A major goal of neuroethics is to derive normative ethical conclusions from the investigation of neural and psychological mechanisms underlying ethical theories, as well as moral judgments and intuitions. The focus of this article is to shed light on the structure and functioning of neuroethical arguments of this sort, and to reveal particular methodological challenges that lie concealed therein. We discuss the methodological problem of how one can--or, as the case may be, cannot--validly infer normative conclusions from neuroscientific observations. Moreover, we raise the issue of how preexisting normative ethical convictions threaten to invalidate the interpretation of neuroscientific data, and thus arrive at question-begging conclusions. Nonetheless, this is not to deny that current neuroethics rightly presumes that moral considerations about actual human lives demand empirically substantiated answers. Therefore, in conclusion, we offer some preliminary reflections on how the discussed methodological challenges can be met. PMID:25985843

  8. MetaPar: Metagenomic Sequence Assembly via Iterative Reclassification

    Kim, MinJi; Ligo, Jonathan G.; Emad, Amin; Farnoud, Farzad; Milenkovic, Olgica; Veeravalli, Venugopal V.

    2013-01-01

    We introduce a parallel algorithmic architecture for metagenomic sequence assembly, termed MetaPar, which allows for significant reductions in assembly time and consequently enables the processing of large genomic datasets on computers with low memory usage. The gist of the approach is to iteratively perform read (re)classification based on phylogenetic marker genes and assembler outputs generated from random subsets of metagenomic reads. Once a sufficiently accurate classification within gen...

  9. Design Studies and Commissioning Plans for PARS Experimental Program

    Mete, O.; Hanahoe, K.; G. Xia; Dover, M.; Wigram, M.; Wright, J.; Zhang, J.; Smith, J.

    2015-01-01

    PARS (Plasma Acceleration Research Station) is an electron beam driven plasma wakefield acceleration test stand proposed for VELA/CLARA facility in Daresbury Laboratory. In order to optimise various operational configurations, 2D numerical studies were performed by using VSIM for a range of parameters such as bunch length, radius, plasma density and positioning of the bunches with respect to each other for the two-beam acceleration scheme. In this paper, some of these numerical studies and co...

  10. Design Studies and Commissioning Plans for PARS Experimental Program

    Mete, O; Xia, G; Dover, M; Wigram, M; Wright, J; Zhang, J; Smith, J

    2015-01-01

    PARS (Plasma Acceleration Research Station) is an electron beam driven plasma wakefield acceleration test stand proposed for VELA/CLARA facility in Daresbury Laboratory. In order to optimise various operational configurations, 2D numerical studies were performed by using VSIM for a range of parameters such as bunch length, radius, plasma density and positioning of the bunches with respect to each other for the two-beam acceleration scheme. In this paper, some of these numerical studies and considered measurement methods are presented.

  11. Four cases of endophthalmitis after 25-gauge pars plana vitrectomy

    Mutoh T; Kadoya K; Chikuda M

    2012-01-01

    Tetsuya Mutoh, Koji Kadoya, Makoto ChikudaDepartment of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, JapanAbstract: We report our recent experience with four cases of endophthalmitis (one male, three females) after 25-gauge pars plana vitrectomy (PPV). One was a case of persistent cystoid macular edema caused by branch retinal vein occlusion, whereas the remaining three were cases of epiretinal membrane. Preoperative antibiotics before the first PPV procedu...

  12. «La Promenade par les aventures surprenants»

    Duarte, Alexandre Freire

    2010-01-01

    É nossa intenção, neste estudo, focar a atenção heurística no par: Jean-Joseph Surin (1600-1665), e Michel de Certeau, um homem que, intermitentemente – revelando uma vida queimada pelo fascínio por Jean-Joseph Surin –, constituiu, nas nossas mãos atentamente vazias, num vasto arvoredo que nos remetia continuamente para uma sombria clareira luminosa que irradiava do meio daquele.

  13. Taare Zameen Par and dyslexic savants

    Chakravarty Ambar

    2009-01-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were ...

  14. The ParMol package for frequent subgraph mining

    Meinl, Thorsten; Wörlein, Marc; Urzova, Olga; Fischer, Ingrid; Philippsen, Michael

    2006-01-01

    Mining for frequent subgraphs in a graph database has become a popular topic in the last years. Algorithms to solve this problem are used in chemoinformatics to find common molecular fragments in a database of molecules represented as two-dimensional graphs. However; the search process in arbitrary graph structures includes costly graph and subgraph isomorphism tests. In our ParMol package we have implemented four of the most popular frequent subgraph miners using a common infrastructure: MoF...

  15. Pars Plana Vitrectomy and Intravitreal Phacoemulsification for Dropped Nuclei

    Khalil Ghasemi Falavarjani; Masih Hashemi; Ali Jalili Fazel; Mehdi Modarres; Hossein Nazari; Mohammad-Mehdi Parvaresh

    2012-01-01

    Purpose: To report the outcomes of pars plana vitrectomy (PPV) and intravitreal phacoemulsification in patients with dropped nuclei/nuclear fragments following complicated cataract surgery. Methods: In this retrospective case series, charts of patients who had undergone PPV and intravitreal phacoemulsification for removal of dislocated nuclei/lens fragments were reviewed. After standard PPV, a conventional phacoemulsification probe with an amputated sleeve was used for grasping and emulsi...

  16. Results of pars plana vitrectomy after complicated phacoemulsification surgery

    Alexandre Grandinetti; Diogo Suenaga; Fernanda M. Oliveira; Krissis Saliba Uliana Cruz; Laurinda Meneguette; Luciane Bugman Moreira

    2015-01-01

    Purpose: To identify the causes and outcomes of pars plana vitrectomy (PPV) in patients undergoing phacoemulsification with intraoperative complication and to analyze whether the interval between phacoemulsification and PPV interferes with best-corrected final visual acuity. Methods: This descriptive and retrospective analytical study was conducted in Paraná Eye Hospital in 2013. Data were collected from medical records of 38 patients who underwent complicated phacoemulsification and also req...

  17. Monitoreo de parásitos en efluentes domiciliarios Control of parasites in domestic sewage

    Liliana Semenas

    1999-08-01

    vermicularis e III (Ascaris lumbricoides, Ancylostoma duodenale e Trichuris trichiura. CONCLUSÕES: Todas as amostras de semi-sólidos analisadas foram consideradas aptas para seu uso como fertilizantes porque não se registrou em nenhuma delas a presença de ovos viáveis de Ascaris lumbricoides, e somente 6 das amostras líquidas foram consideradas aptas para rego, por carecer de ovos ou por ser sua concentração igual ou inferior a 1 ovo por litro.OBJECTIVE: The evaluation of the presence of parasites in semisolid and liquid sewage in Argentinian Patagonia in view of the fact that this is a restriction for its use. METHODS: The samples taken at 4 Domestic Sewage Plants were analyzed in accordance with Standard Methods for the Examination of Water and Wastewater, Environmental Protection Agency, World Health Organization and some other classifications. RESULTS: Only 2 of 6 semisolid samples analyzed had non-viable Ascaris lumbricoides eggs. Of the 10 liquid samples analyzed, only 2 did not contain eggs whereas the remaining ones had pathogens of categories I (Giardia sp., Hymenolepis nana and Enterobius vermicularis and III (Ascaris lumbricoides, Ancylostoma duodenale and Trichuris trichiura. CONCLUSIONS: All semisolid samples turned out to be satisfactory for use as fertilizer as no viable Ascaris lumbricoides eggs were found in any of them. But only 6 of the liquid samples were satisfactory for use as they had no eggs or their concentrations was equal to or less than 1 egg per litre.

  18. Protease activated receptors (PARS) mediation in gyroxin biological activity

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH2, respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  19. The valid conclusion of the compromise/transaction contract. Special rules

    Georgeta-Bianca SPÎRCHEZ

    2012-12-01

    Full Text Available In this paper we aimed to examine the legal mechanisms that ensure the protection of the parties within this form of private justice-that of compromise conclusion. For a systematic approach of this subject, we reported, first of all, to the general rules governing, in terms of validity, the conclusion of conventions, but mostly we leaned on the particular aspects relating to this specific contract. In order to respond to the main objectives, we reviewed the legal requirements in force and the way the case law interpreted them and also the relevant arguments brought by the doctrine. The research methodology took into account elements of comparative law; we followed, in this respect, the French regulatory model and the Anglo-Saxon common law which is favorable to the conclusion of this type of contract.

  20. The grand leap of the whale up the Niagara Falls: converting philosophical conclusions into policy prescriptions.

    Holm, Søren

    2015-04-01

    This article analyzes a neat conjuring trick employed in bioethics, that is, the immediate conversion of a philosophical conclusion into a policy prescription, and compares it to the "grand leap of the whale up the Niagara Falls" mentioned by Benjamin Franklin. It is shown that there is no simple and easy way to achieve the conversion, by considering arguments falling under four headings: (1) reasonable disagreement about values and theories, (2) general jurisprudential arguments, (3) the differences between policymaking and philosophy, and (4) the messy world of implementation. The particular issue used to illustrate the difficulties in moving from philosophical conclusion to policy description is infanticide of healthy infants, but the analysis is general, and the conclusion that the immediate move to policy is illegitimate is quite general. PMID:25719355

  1. ParB Partition Proteins: Complex Formation and Spreading at Bacterial and Plasmid Centromeres.

    Funnell, Barbara E

    2016-01-01

    In bacteria, active partition systems contribute to the faithful segregation of both chromosomes and low-copy-number plasmids. Each system depends on a site-specific DNA binding protein to recognize and assemble a partition complex at a centromere-like site, commonly called parS. Many plasmid, and all chromosomal centromere-binding proteins are dimeric helix-turn-helix DNA binding proteins, which are commonly named ParB. Although the overall sequence conservation among ParBs is not high, the proteins share similar domain and functional organization, and they assemble into similar higher-order complexes. In vivo, ParBs "spread," that is, DNA binding extends away from the parS site into the surrounding non-specific DNA, a feature that reflects higher-order complex assembly. ParBs bridge and pair DNA at parS and non-specific DNA sites. ParB dimers interact with each other via flexible conformations of an N-terminal region. This review will focus on the properties of the HTH centromere-binding protein, in light of recent experimental evidence and models that are adding to our understanding of how these proteins assemble into large and dynamic partition complexes at and around their specific DNA sites. PMID:27622187

  2. Esophageal impedance baseline according to different time intervals

    Ummarino Dario

    2012-06-01

    Full Text Available Abstract Background The impedance baseline has been shown to reflect esophageal integrity, and to be decreased in patients with esophagitis. However, different methods for the determination of the impedance baseline have not been compared. Methods The median impedance baseline was calculated in 10 consecutive multichannel intraluminal impedance recordings in children with non-erosive reflux disease. All children underwent an endoscopy with a biopsy as part of the clinical work-up to exclude esophagitis. The impedance baseline was obtained both by including and excluding all impedance episodes (IE; reflux, swallows and gas episodes during the full recording, and during the first 1-minute period without an IE every hour (method 1, every 2 hours (method 2 or every 4 hours (method 3. The impedance baseline obtained during the full recording was set at 100%, and the variation (difference in impedance baseline for the different methods and variability (difference in impedance baseline during one analysis period were assessed. Results None of the participants had esophagitis. The mean difference over the six channels between the impedance baseline over the total recording with and without IE was approximately 2.5%, and comparable for each channel (range 0.47% to 5.55%. A mean of 1,028 IEs were excluded in each tracing, and it took between 4 and 24 hours to delete all events in one tracing. The difference in the impedance baseline obtained with and without IEs was mainly caused by the gas episodes in the upper channels and swallows in the lower channels. The median impedance baseline according to the three one-minute analysis methods was comparable to the median impedance baseline according to the 24 hour analysis. Conclusions The automatic determination of the median impedance baseline over the total tracing including IEs is an adequate method. In isolated tracings with numerous IEs, the calculation of the median impedance baseline over one minute

  3. Optimal conclusive teleportation of a d-dimensional two-particle unknown quantum state

    Yang Yu-Guang; Wen Qiao-Yan; Zhu Fu-Chen

    2006-01-01

    A conclusive teleportation protocol of a d-dimensional two-particle unknown quantum state using three ddimensional particles in an arbitrary pure state is proposed. A sender teleports the unknown state conclusively to a receiver by using the positive operator valued measure(POVM) and introducing an ancillary qudit to perform the generalized Bell basis measurement. We calculate the optimal teleportation fidelity. We also discuss and analyse the reason why the information on the teleported state is lost in the course of the protocol.

  4. Conclusion on the peer review of the pesticide risk assessment of the active substance tembotrione

    European Food Safety Authority

    2013-03-01

    Full Text Available The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State Austria, for the pesticide active substance tembotrione are reported. The context of the peer review was that required by Commission Regulation (EU No 188/2011. The conclusions were reached on the basis of the evaluation of the representative uses of tembotrione as a herbicide on maize and sweet corn. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented.

  5. A Bipolar Spindle of Antiparallel ParM Filaments Drives Bacterial Plasmid Segregation

    Gayathri, P; Fujii, T; Møller-Jensen, Jakob;

    2012-01-01

    To ensure their stable inheritance by daughter cells during cell division, bacterial low copy-number plasmids make simple DNA segregating machines that use an elongating protein filament between sister plasmids. In the ParMRC system of Escherichia coli R1 plasmid, ParM, an actin-like protein, forms...... the spindle between ParRC complexes on sister plasmids. Using a combination of structural work and total internal reflection fluorescence microscopy, we show that ParRC bound and could accelerate growth at only one end of polar ParM filaments, mechanistically resembling eukaryotic formins. The architecture...... of ParM filaments enabled two ParRC-bound filaments to associate in an antiparallel orientation, forming a bipolar spindle. The spindle elongated as a bundle of at least two antiparallel filaments, thereby pushing two plasmid clusters toward the poles....

  6. NMDA receptor subunit expression and PAR2 receptor activation in colospinal afferent neurons (CANs during inflammation induced visceral hypersensitivity

    Caudle Robert M

    2009-09-01

    Full Text Available Abstract Background Visceral hypersensitivity is a clinical observation made when diagnosing patients with functional bowel disorders. The cause of visceral hypersensitivity is unknown but is thought to be attributed to inflammation. Previously we demonstrated that a unique set of enteric neurons, colospinal afferent neurons (CANs, co-localize with the NR1 and NR2D subunits of the NMDA receptor as well as with the PAR2 receptor. The aim of this study was to determine if NMDA and PAR2 receptors expressed on CANs contribute to visceral hypersensitivity following inflammation. Recently, work has suggested that dorsal root ganglion (DRG neurons expressing the transient receptor potential vanilloid-1 (TRPV1 receptor mediate inflammation induced visceral hypersensitivity. Therefore, in order to study CAN involvement in visceral hypersensitivity, DRG neurons expressing the TRPV1 receptor were lesioned with resiniferatoxin (RTX prior to inflammation and behavioural testing. Results CANs do not express the TRPV1 receptor; therefore, they survive following RTX injection. RTX treatment resulted in a significant decrease in TRPV1 expressing neurons in the colon and immunohistochemical analysis revealed no change in peptide or receptor expression in CANs following RTX lesioning as compared to control data. Behavioral studies determined that both inflamed non-RTX and RTX animals showed a decrease in balloon pressure threshold as compared to controls. Immunohistochemical analysis demonstrated that the NR1 cassettes, N1 and C1, of the NMDA receptor on CANs were up-regulated following inflammation. Furthermore, inflammation resulted in the activation of the PAR2 receptors expressed on CANs. Conclusion Our data show that inflammation causes an up-regulation of the NMDA receptor and the activation of the PAR2 receptor expressed on CANs. These changes are associated with a decrease in balloon pressure in response to colorectal distension in non-RTX and RTX lesioned

  7. Fluoroquinolone resistance and molecular characterization of gyrA and parC quinolone resistance-determining regions in Escherichia coli isolated from poultry.

    Vanni, M; Meucci, V; Tognetti, R; Cagnardi, P; Montesissa, C; Piccirillo, A; Rossi, A M; Di Bello, D; Intorre, L

    2014-04-01

    Escherichia coli are a common inhabitant of the gastrointestinal tract of mammals and birds; nevertheless, they may be associated with a variety of severe and invasive infections. Whereas fluoroquinolones (FQ) have been banned in the United States for use in poultry production, the use of these antimicrobials in poultry husbandry is still possible in the European Union, although with some restrictions. The aim of this study was to investigate the FQ resistance of 235 E. coli isolates recovered from chickens and turkeys. Minimum inhibitory concentrations were determined by a microdilution method, whereas mutations in the quinolone resistance-determining regions of the target genes, gyrA and parC, were detected by a PCR-based method. High resistance rates (>60%) were observed for nalidixic acid, flumequine, and difloxacin, whereas resistance to ciprofloxacin, danofloxacin, enrofloxacin, marbofloxacin, and sarafloxacin was less frequently reported (difloxacin, danofloxacin, and sarafloxacin had in addition 1 or 2 parC substitutions. Two gyrA mutations coupled with 1 substitution in parC were detected in isolates resistant to all tested FQ. The number of mutations and their correlation with the in vitro activity of FQ reflected the currently accepted model, according to which a single gyrA substitution is associated with resistance or decreased susceptibility to older quinolones, whereas further gyrA or parC substitutions are needed for a higher level of resistance. PMID:24706962

  8. Sustainability of UK forestry: contemporary issues for the protection of freshwaters, a conclusion

    Neal, C.; Ormerod, S. J.; Langan, S. J.; Nisbet, T. R.; Roberts, J.

    2004-01-01

    This paper closes the Special Issue of Hydrology and Earth System Sciences entitled "Sustainability of UK forestry: contemporary issues for the protection of freshwaters" by presenting conclusions from the contributions together with associated research findings. The volume deals largely with issues of upland water quality and biology in the context of environmental research and management. The studies are linked to an array of issue...

  9. 10 CFR 709.16 - Application of Counterintelligence Evaluation Review Boards in reaching conclusions regarding CI...

    2010-01-01

    ... Boards in reaching conclusions regarding CI evaluations. 709.16 Section 709.16 Energy DEPARTMENT OF ENERGY COUNTERINTELLIGENCE EVALUATION PROGRAM CI Evaluation Protocols and Protection of National Security... CI evaluations. (a) General. If the results of a counterintelligence evaluation are not...

  10. Oklo: The fossil nuclear reactors. Physics study - Translation of chapters 6, 13 and conclusions

    Three parts of the 1991 book 'Oklo: reacteurs nucleaires fossiles. Etude physique' have been translated in this report. The chapters bear the titles 'Study of criticality'(45 p.), 'Some problems with the overall functioning of the reactor zones'(45 p.) and 'Conclusions' (15 p.), respectively

  11. Conclusions and recommendations. [for problems in energy situation, air transportation, and hydrogen fuel

    1973-01-01

    Conclusions and recommendations are presented for an analysis of the total energy situation; the effect of the energy problem on air transportation; and hydrogen fuel for aircraft. Properties and production costs of fuels, future prediction for energy and transportation, and economic aspects of hydrogen production are appended.

  12. 20 CFR 410.471 - Conclusion by physician regarding miner's disability or death.

    2010-04-01

    ... to Pneumoconiosis § 410.471 Conclusion by physician regarding miner's disability or death. The function of deciding whether or not an individual is totally disabled due to pneumoconiosis, or was totally disabled due to pneumoconiosis at the time of his death, or that his death was due to pneumoconiosis,...

  13. HERBAL PRODUCT REALIZATION IN ACCORDANCE WITH WHO AND ISO GUIDELINES

    S. J. Ameh et al

    2012-10-01

    Full Text Available Background: Following the Alma-Ata Declaration of 1978, the World Health Organization (WHO began the issuance of guidelines for developing standardized herbal preparations from Traditional Medicine (TM. Similarly in 1987, the International Organization for Standardization (ISO launched the most anticipated industrial standard (ISO 9001 in world history. The seventh (7th clause of ISO 9001’s eight clauses is devoted to “Product Realization”- a quality management system (QMS procedure that includes: planning of product realization; appreciation of customer-related processes; design and development processes; purchasing; production and service provision; and control of measuring and monitoring equipment. Purpose: The article takes a hard look at the QMS processes involved in product realization and the critical stages of the WHO model of herbal drug development from TM, with a view to devising a framework that can be used to promote the production of quality herbal products, commencing from the stage of ethnobotanical survey, through the laboratory, to the clinic.Methodology: Both the WHO model of herbal drug development and the 7th clause of ISO 9001:2008 were critically reviewed and combined to yield a framework that is discussed within the context of guiding herbal drug development from TM. Results and Discussion: The resulting WHO-ISO framework of herbal product realization is discussed in terms of its relevance to practical problems of GMP-production using herbal starting materials, given their innate variability in composition, potency and appearance. Conclusion: The provisions of ISO 9001’s seventh clause can, to a large extent, be applied to the production of quality herbal products developed in accordance with WHO.

  14. Juvenile idiopathic arthritis outcome and prognosis according to catamnesis evaluation

    O V Semenova

    2005-01-01

    Full Text Available Objective. To study outcome and prognosis in pts with juvenile idiopathic arthritis (JIA. Material and methods. 239 JIA pts with disease duration of 10 years and more were analyzed. 80 children and adolescents before 18 years old (66 girls and 14 boys were included in group 1. Arthritis clinical and laboratory activity, radiological stage and functional status according to Steinbroker and CHAQ questionnaire were assessed. 159 grown up pts (109 female and 50 male suffering from JIA from childhood were included in group 2. They were examined using Stanford Health Assessment Questionnaire (HAQ and a specially developed social status questionnaire. Results. Half pts of group 1 had recurrence of the disease during examination but activity in most cases did not exceed stage I or 2 (54% and 31% respectively. Joint destructive changes were revealed in 50% of pts. 80% of pts had radiological signs of secondary osteoarthritis. Amyloidosis was revealed in 2 from 27 pts with systemic type of JIA. 68% of pts had 1 or 2 functional class. 1/3 of pts did not have functional limitations (CHAQ=0. 13% of pts had maximal disability with CHAQ ranging from 2,1 to 3,0 (pts with polyarticular and systemic types of JIA. Most grown up pts (59% considered their health as good. Substantial part of them worked or learned. 10 pts did not worked because of the disease (1,5%. 61% of pts did not have functional limitations (HAQ=0. 32% of pts were disabled. Most of them had 3 or 2 disability degree and had possibility to work. Conclusion. Substantial part of pts with longstanding JIA have stabilization of the disease or remission. Recurrent course of the disease was characterized by decrease of activity. Most children and grown ups with longstanding disease have relatively benign functional outcome. Pts with polyarticular and systemic types of JIA require especial attention because they have maximal risk of joint destruction with severe disability.

  15. Pleasurable music affects reinforcement learning according to the listener.

    Gold, Benjamin P; Frank, Michael J; Bogert, Brigitte; Brattico, Elvira

    2013-01-01

    Mounting evidence links the enjoyment of music to brain areas implicated in emotion and the dopaminergic reward system. In particular, dopamine release in the ventral striatum seems to play a major role in the rewarding aspect of music listening. Striatal dopamine also influences reinforcement learning, such that subjects with greater dopamine efficacy learn better to approach rewards while those with lesser dopamine efficacy learn better to avoid punishments. In this study, we explored the practical implications of musical pleasure through its ability to facilitate reinforcement learning via non-pharmacological dopamine elicitation. Subjects from a wide variety of musical backgrounds chose a pleasurable and a neutral piece of music from an experimenter-compiled database, and then listened to one or both of these pieces (according to pseudo-random group assignment) as they performed a reinforcement learning task dependent on dopamine transmission. We assessed musical backgrounds as well as typical listening patterns with the new Helsinki Inventory of Music and Affective Behaviors (HIMAB), and separately investigated behavior for the training and test phases of the learning task. Subjects with more musical experience trained better with neutral music and tested better with pleasurable music, while those with less musical experience exhibited the opposite effect. HIMAB results regarding listening behaviors and subjective music ratings indicate that these effects arose from different listening styles: namely, more affective listening in non-musicians and more analytical listening in musicians. In conclusion, musical pleasure was able to influence task performance, and the shape of this effect depended on group and individual factors. These findings have implications in affective neuroscience, neuroaesthetics, learning, and music therapy. PMID:23970875

  16. Pleasurable music affects reinforcement learning according to the listener

    Benjamin P Gold

    2013-08-01

    Full Text Available Mounting evidence links the enjoyment of music to brain areas implicated in emotion and the dopaminergic reward system. In particular, dopamine release in the ventral striatum seems to play a major role in the rewarding aspect of music listening. Striatal dopamine also influences reinforcement learning, such that subjects with greater dopamine efficacy learn better to approach rewards while those with lesser dopamine efficacy learn better to avoid punishments. In this study, we explored the practical implications of musical pleasure through its ability to facilitate reinforcement learning via non-pharmacological dopamine elicitation. Subjects from a wide variety of musical backgrounds chose a pleasurable and a neutral piece of music from an experimenter-compiled database, and then listened to one or both of these pieces (according to pseudo-random group assignment as they performed a reinforcement learning task dependent on dopamine transmission. We assessed musical backgrounds as well as typical listening patterns with the new Helsinki Inventory of Music and Affective Behaviors (HIMAB, and separately investigated behavior for the training and test phases of the learning task. Subjects with more musical experience trained better with neutral music and tested better with pleasurable music, while those with less musical experience exhibited the opposite effect. HIMAB results regarding listening behaviors and subjective music ratings indicate that these effects arose from different listening styles: namely, more affective listening in non-musicians and more analytical listening in musicians. In conclusion, musical pleasure was able to influence task performance, and the shape of this effect depended on group and individual factors. These findings have implications in affective neuroscience, neuroaesthetics, learning, and music therapy.

  17. Dosimetry of 64Cu-DOTA-AE105, a PET tracer for uPAR imaging

    Persson, Morten; El Ali, Henrik H.; Binderup, Tina;

    2014-01-01

    the heart wall to receive the highest dose (0.0918mSv/MBq) followed by the liver (0.0815mSv/MBq), All other organs/tissue were estimated to receive doses in the range of 0.02–0.04mSv/MBq. The mean effective whole-body dose of 64Cu-DOTA-AE105 was estimated to be 0.0317mSv/MBq. Relatively good....... ConclusionFavorable dosimetry estimates together with previously reported uPAR PET data fully support human testing of 64Cu-DOTA-AE105....

  18. A mechanism for ParB-dependent waves of ParA, a protein related to DNA segregation during cell division in prokaryotes

    Hunding, Axel; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2003-01-01

    Prokaryotic plasmids encode partitioning (par) loci involved in segregation of DNA to daughter cells at cell division. A functional fusion protein consisting of Walker-type ParA ATPase and green fluorescent protein (Gfp) oscillates back and forth within nucleoid regions with a wave period of about...

  19. Validation of MODIS and GEOV1 fPAR Products in a Boreal Forest Site in Finland

    Titta Majasalmi

    2015-01-01

    Full Text Available Remote sensing of the fraction of absorbed Photosynthetically Active Radiation (fPAR has become a timely option to monitor forest productivity. However, only a few studies have had ground reference fPAR datasets containing both forest canopy and understory fPAR from boreal forests for the validation of satellite products. The aim of this paper was to assess the performance of two currently available satellite-based fPAR products: MODIS fPAR (MOD15A2, C5 and GEOV1 fPAR (g2_BIOPAR_FAPAR, as well as an NDVI-fPAR relationship applied to the MODIS surface reflectance product and a Landsat 8 image, in a boreal forest site in Finland. Our study area covered 16 km2 and field data were collected from 307 forest plots. For all plots, we obtained both forest canopy fPAR and understory fPAR. The ground reference total fPAR agreed better with GEOV1 fPAR than with MODIS fPAR, which showed much more temporal variation during the peak-season than GEOV1 fPAR. At the chosen intercomparison date in peak growing season, MODIS NDVI based fPAR estimates were similar to GEOV1 fPAR, and produced on average 0.01 fPAR units smaller fPAR estimates than ground reference total fPAR. MODIS fPAR and Landsat 8 NDVI based fPAR estimates were similar to forest canopy fPAR.

  20. Outcomes of 23-gauge pars plana vitrectomy and internal limiting membrane peeling with brilliant blue in macular hole

    Nohutcu A

    2011-08-01

    Full Text Available Huseyin Sanisoglu1, Mehmet Sahin Sevim1, Betul Aktas1, Semra Sevim2, Ahmet Nohutcu11Haydarpasa Numune Education and Research Hospital, Department of Ophthalmology, 2Uskudar State Hospital, Eye Clinic, Istanbul, TurkeyPurpose: The evaluation of anatomic and visual outcomes in macular hole cases treated with internal limiting membrane (ILM peeling, brilliant blue (BB, and 23-gauge pars plana vitrectomy (PPV.Materials and methods: Fifty eyes of 48 patients who presented between July 2007 and December 2009 with the diagnosis of stage 2, 3, or 4 macular holes according to Gass Classification who had undergone PPV and ILM peeling were included in this study. Pre- and postoperative macular examinations were assessed with spectral-domain optical coherence tomography. 23 G sutureless PPV and ILM peeling with BB was performed on all patients.Results: The mean age of patients was 63.34 ± 9.6 years. Stage 2 macular hole was determined in 17 eyes (34%, stage 3 in 24 eyes (48%, and stage 4 in 9 eyes (18%. The mean follow-up time was 13.6 ± 1.09 months. Anatomic closure was detected in 46/50 eyes (92%, whereas, in four cases, macular hole persisted and a second operation was not required due to subretinal fluid drainage. At follow-up after 2 months, persistant macular hole was detected in one case and it was closed with reoperation. At 12 months, an increase in visual acuity in 41 eyes was observed, while it remained at the same level in six eyes. In three eyes visual acuity decreased. There was a postoperative statistically significant increase in visual acuity in stage 2 and 3 cases (P < 0.05, however, no increase in visual acuity in stage 4 cases was observed.Conclusion: PPV and ILM peeling in stage 2, 3, and 4 macular hole cases provide successful anatomic outcomes, however, in delayed cases, due to photoreceptor loss, it has no effect on functional recovery. BB, used for clarity of ILM, may be beneficial due to its low retinal toxicity.Keywords: macular

  1. Refurbishment of Public Buildings according to Sustainability Principles

    Kaminski, Aistė

    2008-01-01

    The main idea of current PhD thesis is an analysis of the public buildings refurbishment according to sustainability principles. The objects of investigation are refurbishment process of public buildings by emphasizing decision making process according to sustainability principles, decision making groups that take part in refurbishment process and affordability principle concerning sustainable refurbishment. The aim of work is influence on scope of refurbishment of public buildings according ...

  2. Conclusion on the peer review of the pesticide risk assessment of the active substance ferric phosphate

    European Food Safety Authority

    2015-01-01

    Full Text Available The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State Germany, for the pesticide active substance ferric phosphate are reported. The context of the peer review was that required by Commission Regulation (EU No 1141/2010 as amended by Commission Implementing Regulation (EU No 380/2013. The conclusions were reached on the basis of the evaluation of the representative use of ferric phosphate as a molluscicide in agriculture and horticulture for control of harmful slug and snail species in all edible and non-edible crops. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed. A concern was identified.

  3. Conclusion on the peer review of the pesticide risk assessment of the active substance penflufen

    European Food Safety Authority

    2012-08-01

    Full Text Available

    The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State the United Kingdom, for the pesticide active substance penflufen are reported. The context of the peer review was that required by Commission Regulation (EU No 188/2011. The conclusions were reached on the basis of the evaluation of the representative use of penflufen as a fungicide on potatoes. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.

  4. Conclusion on the peer review of the pesticide risk assessment of the active substance pyridalyl

    European Food Safety Authority

    2013-08-01

    Full Text Available The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State the Netherlands, for the pesticide active substance pyridalyl are reported. The context of the peer review was that required by Commission Regulation (EUNo 188/2011. The conclusions were reached on the basis of the evaluation of the representative uses of pyridalyl as an insecticide on field and glasshouse tomato, aubergine, sweet and chilli pepper, and on field cucurbits, lettuce and cotton. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.

  5. Conclusion on the peer review of the pesticide risk assessment of the active substance spiromesifen

    European Food Safety Authority

    2012-10-01

    Full Text Available

    The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State, the United Kingdom, for the pesticide active substance spiromesifen are reported. The context of the peer review was that required by Commission Regulation (EU No 188/2011. The conclusions were reached on the basis of the evaluation of the representative uses of spiromesifen as an insecticide and acaricide on cucumber, courgette, pepper, tomato, eggplant (aubergine, French bean, melon, strawberry and ornamentals in permanent greenhouses. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.

  6. Conclusion on the peer review of the pesticide risk assessment of the active substance acequinocyl

    European Food Safety Authority

    2013-05-01

    Full Text Available The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State the Netherlands, for the pesticide active substance acequinocyl are reported. The context of the peer review was that required by Commission Regulation (EU No 188/2011. The conclusions were reached on the basis of the evaluation of the representative uses as an acaricide on ornamentals, apples and pears. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified for all the outdoor uses assessed.

  7. Conclusion on the peer review of the pesticide risk assessment of the active substance triasulfuron

    European Food Safety Authority

    2015-01-01

    Full Text Available The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State France and the co-rapporteur Member State Denmark for the pesticide active substance triasulfuron are reported. The context of the peer review was that required by Commission Regulation (EU No 1141/2010 as amended by Commission Implementing Regulation (EU No 380/2013. The conclusions were reached on the basis of the evaluation of the representative use of triasulfuron as a herbicide on winter cereals. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.

  8. Conclusion on the peer review of the pesticide risk assessment of the active substance valifenalate

    European Food Safety Authority

    2013-06-01

    Full Text Available The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State, Hungary, for the pesticide active substance valifenalate are reported. The context of the peer review was that required by Commission Regulation (EU No 188/2011. The conclusions were reached on the basis of the evaluation of the representative use of valifenalate as a fungicide on grapes. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.

  9. Conclusion on the peer review of the pesticide risk assessment of the active substance tebuconazole

    European Food Safety Authority

    2014-01-01

    Full Text Available The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State Denmark, for the pesticide active substance tebuconazole are reported. The context of the peer review was that required by Regulation (EC No 1107/2009. The conclusions were reached on the basis of the evaluation of the representative uses of tebuconazole as a fungicide on cereals (wheat, barley, oat, rye and grape (wine and table and as a plant growth regulator in oilseed rape. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.

  10. Conclusion on the peer review of the pesticide risk assessment of the active substance geraniol

    European Food Safety Authority

    2012-11-01

    Full Text Available The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State, the United Kingdom, for the pesticide active substance geraniol are reported. The context of the peer review was that required by Commission Regulation (EU No 188/2011. The conclusions were reached on the basis of the evaluation of the representative uses of geraniol as a fungicide on table and wine grapes. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.

  11. Conclusion on the peer review of the pesticide risk assessment of the active substance thymol

    European Food Safety Authority

    2012-11-01

    Full Text Available The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State, the United Kingdom, for the pesticide active substance thymol are reported. The context of the peer review was that required by Commission Regulation (EU No 188/2011. The conclusions were reached on the basis of the evaluation of the representative uses of thymol as a fungicide on table and wine grapes. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.

  12. Conclusion on the peer review of the pesticide risk assessment of the active substance orange oil

    European Food Safety Authority

    2013-02-01

    Full Text Available The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State France, for the pesticide active substance orange oil are reported. The context of the peer review was that required by Commission Regulation (EU No 188/2011. The conclusions were reached on the basis of the evaluation of the representative use as an insecticide for the control of whitefly larvae and adults on tomato and courgette (field, glasshouse, indoor. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.

  13. Conclusion on the peer review of the pesticide risk assessment of the active substance pyrethrins

    European Food Safety Authority

    2013-01-01

    Full Text Available The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State Italy, for the pesticide active substance pyrethrins are reported. The context of the peer review was that required by Commission Regulation (EC No 2229/2004, as amended by Commission Regulation (EC No 1095/2007. The conclusions were reached on the basis of the evaluation of the representative uses of pyrethrins as an insecticide on tomato, pepper, cucumber, melons, strawberries, potatoes, lettuce and ornamentals. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.

  14. Conclusion on the peer review of the pesticide risk assessment of the active substance sodium hypochlorite

    European Food Safety Authority

    2012-07-01

    Full Text Available

    The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State The Netherlands, for the pesticide active substance sodium hypochlorite are reported. The context of the peer review was that required by Commission Regulation (EC No 2229/2004 as amended by Commission Regulation (EC No 1095/2007 and Commission Regulation (EU No 114/2010. The conclusions were reached on the basis of the evaluation of the representative use of sodium hypochlorite as a bactericide on mushrooms. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.

  15. EMU Fiscal Challenges: Conclusions for the New Members of the EU

    Sławomir Bukowski

    2004-01-01

    The aim of the paper is to evaluate the fiscal challenges which have appeared before EMU (Economic and Monetary Union) countries after four years of monetary union functioning. Then the author formulates conclusions for accession countries, which plan to be members of EMU in the near future. The first part of the paper deals with criteria of fiscal stabilization within EMU, their meaning and connections with economic growth. The fiscal stabilization criteria were taken from the Pact of Stabil...

  16. Time & Law - Is it the nature of law to last? A Conclusion.

    Van Hoecke, Mark

    1998-01-01

    About conceptions of time (physical time, human time, legal time) and conceptions of time in law (founding time, timeless time of legal doctrine, instant time, longlasting time, consolidation time, voluntarist future time, aleatory time, anarchic time, alternating time). Conceptions of the future (the instant view - no future, the empty view - a completely open future, the half-full view : an open future, party determined by the past). Conclusion : towards a dialectical time conception.

  17. The Pakistani Madrassah and Terrorism: Made and Unmade Conclusions from the Literature

    Nikhil Raymond Puri

    2010-01-01

    This paper revisits the relationship between Pakistani religious schools and terrorism. While much of the literature informs the enduring perception that madrassahs breed terror, some recent studies have begun to question the extent to which religious schools drive militancy. The analysis below balances these ostensibly incompatible positions – alarm and skepticism are equally misplaced. With a focus on evidence, and warranted and unwarranted conclusions provided by the literature, this...

  18. Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of sixth biannual meeting (September 2014).

    WHO Malaria Policy Advisory Committee and Secretariat

    2015-01-01

    The Malaria Policy Advisory Committee to the World Health Organization held its sixth meeting in Geneva, Switzerland from 10 to 12 September 2014. This article provides a summary of the discussions, conclusions and recommendations from that meeting.Meeting sessions covered the following: an update on drug resistance and containment including an assessment on the feasibility of elimination of Plasmodium falciparum malaria in the Greater Mekong Subregion; guidance on the control of residual mal...

  19. Blast Testing Issues and TBI: Experimental Models That Lead to Wrong Conclusions

    Needham, Charles E.; Ritzel, David; Rule, Gregory T.; Wiri, Suthee; Young, Leanne

    2015-01-01

    Over the past several years, we have noticed an increase in the number of blast injury studies published in peer-reviewed biomedical journals that have utilized improperly conceived experiments. Data from these studies will lead to false conclusions and more confusion than advancement in the understanding of blast injury, particularly blast neurotrauma. Computational methods to properly characterize the blast environment have been available for decades. These methods, combined with a basic un...

  20. Presentation of conclusions of the 9. meeting of the working group on the division by four of the greenhouse gases emissions in France for 2050, called factor 4; Releve de conclusions de la 9. reunion du groupe de travail sur la division par quatre des emissions de gaz a effet de serre de la France a l'horizon 2050, dit Facteur 4

    Lamblin, V

    2006-05-15

    This document provides opinions and recommendations of the working group on the factor 4. It deals with the individual behaviors and their positive evolution, the part of the public policies, the actions of the CITEPA, the scientific context about the greenhouse gases decrease objectives, the works of the factor 4 and the long dated reduction aboard. (A.L.B.)

  1. Increase of doses delivered to patients during medical imagery examinations. Conclusions of 16 September 2010 seminar organized by the ASN; Augmentation des doses delivrees aux patients lors des examens d'imagerie medicale. Conclusions du seminaire du 16 septembre 2010 organise par l'ASN

    NONE

    2011-07-01

    This document reports the contributions of the participants to the seminar which aimed at discussing the increase of doses delivered in medical imagery, and the actions to undertake to limit this increase. The authors recall the regulatory and legal context regarding the optimization of medical procedures and the organisation of radiation protection for medical exposures, comment the assessment of exposures by medical imagery in 2007, comment the CE marking of medical devices, the recent evolutions in dose optimization of radiology and scanography devices. Other sets of interventions address the application of the justification and optimization principle by professionals (in new scanography practices, in radio-paediatrics), the professional training issue (radiologist continuous training, electro-radiology operator training), the comparison between scanner and RMI (new fields for RMI, imagery benchmark), the assessment of professional practices (tools for continuous professional development of health professionals, medical imagery initiatives in Belgium), and international recommendations (by the IAEA, the WHO, the European Union)

  2. Par-4-mediated recruitment of Amida to the actin cytoskeleton leads to the induction of apoptosis

    Par-4 (prostate apoptosis response-4) sensitizes cells to apoptotic stimuli, but the exact mechanisms are still poorly understood. Using Par-4 as bait in a yeast two-hybrid screen, we identified Amida as a novel interaction partner, a ubiquitously expressed protein which has been suggested to be involved in apoptotic processes. Complex formation of Par-4 and Amida occurs in vitro and in vivo and is mediated via the C-termini of both proteins, involving the leucine zipper of Par-4. Amida resides mainly in the nucleus but displays nucleo-cytoplasmic shuttling in heterokaryons. Upon coexpression with Par-4 in REF52.2 cells, Amida translocates to the cytoplasm and is recruited to actin filaments by Par-4, resulting in enhanced induction of apoptosis. The synergistic effect of Amida/Par-4 complexes on the induction of apoptosis is abrogated when either Amida/Par-4 complex formation or association of these complexes with the actin cytoskeleton is impaired, indicating that the Par-4-mediated relocation of Amida to the actin cytoskeleton is crucial for the pro-apoptotic function of Par-4/Amida complexes in REF52.2 cells. The latter results in enhanced phosphorylation of the regulatory light chain of myosin II (MLC) as has previously been shown for Par-4-mediated recruitment of DAP-like kinase (Dlk), suggesting that the recruitment of nuclear proteins involved in the regulation of apoptotic processes to the actin filament system by Par-4 represents a potent mechanism how Par-4 can trigger apoptosis

  3. Revisit of I35W Bridge Collapse: A preliminary analysis at 2007 and conclusions today

    August 1st of 2007, 6:05PM, the interstate highway I35W Bridge in the City Minneapolis, Minnesota, collapsed suddenly. The 8 traffic-lane, 1000-foot-long deck of the 1907-foot-long bridge fell into Mississippi River within seconds, resulted in 13 fatalities and 145 injuries. This paper is based on a report of a preliminary analysis of this disaster, which was submitted to the related administrative agencies at the September of 2007. By comparing the results in that report with the materials' evidences of National Safety Transportation Safety Board (NTSB) official investigation and recent in-depth analyses, it seems that the issues addressed in this earlier analysis may still have certain significance for the safety assessment of those similarly-structured steel bridges today. A bridge's service life is 75 years or longer. According to a NTSB's document, there are more than hundreds this kind of bridges still on service.

  4. 42 CFR 56.105 - Accord with health planning.

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Accord with health planning. 56.105 Section 56.105... HEALTH SERVICES General Provisions § 56.105 Accord with health planning. A grant may be made under this... appropriate health planning agencies have been met....

  5. 42 CFR 51c.105 - Accord with health planning.

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Accord with health planning. 51c.105 Section 51c... COMMUNITY HEALTH SERVICES General Provisions § 51c.105 Accord with health planning. A grant may be made... approval by the appropriate health planning agencies have been met....

  6. A prospective study on postoperative discomfort after 20-gauge pars plana vitrectomy

    Yu JG

    2015-07-01

    Full Text Available Ji-guo Yu,1,* Fang Ni,1,* Yi Xiang,1 Yi-fan Feng,2 Jue Wang,1 Xun-an Fu11Department of Ophthalmology, the Central Hospital of Wuhan, Wuhan, Hubei Province, 2Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this workPurpose: To evaluate postoperative pain and other irritation symptoms after 20-gauge (20G pars plana vitrectomy.Materials and methods: A total of 110 consecutive patients were enrolled in our studies, and 87 patients who underwent the conventional 20G pars plana vitrectomy were included in the final analysis. All vitrectomies were performed using the same surgical technique by the same surgeon. Patients were examined before surgery and 1 day, 3 days, 7 days, 1 month, and 2 months postoperatively. The main outcome measures include patient age and sex, intraocular pressure (IOP, ocular pain, pain score, pain medication use, and other irritation symptoms comprising itching, foreign body sensation, burning, photophobia, and dryness. The pain was evaluated using the Numerical Rating Scale scored from 0 to 10.Results: Postoperative pain was relatively common during the first day after surgery, as it was reported by 43 (49.4% patients. Then, the prevalence gradually decreased to eleven (12.6% patients at 2 months. Most patients reported mild or moderate pain, with a pain score of 1–5, but only four patients were given analgesics for ocular pain. A postoperative rise of IOP was noted in 25 patients at day 1. Most of these patients with high IOP reported moderate pain. Other ocular irritation symptoms were varied after surgery. There was still one-quarter of patients that had foreign body sensation and dryness symptoms at month 2 after surgery.Conclusion: Mild and moderate ocular pain were relatively common after 20G vitrectomy, which is more often associated with elevated IOP. Other irritation symptoms were also presented after surgery and could

  7. Transconjunctival 25-gauge pars plana vitrectomy and internal limiting membrane peeling for chronic macular edema

    Cho M

    2012-07-01

    Full Text Available Minhee Cho, Donald J D'AmicoWeill Cornell Medical College, Department of Ophthalmology, New York, NY, USABackground: The purpose of this study was to investigate the visual and anatomic outcomes in patients with chronic macular edema who underwent 25-gauge pars plana vitrectomy with internal limiting membrane peeling.Methods: This study was a retrospective chart review of 24 eyes from 21 patients who underwent 25-gauge pars plana vitrectomy and indocyanine green-assisted internal limiting membrane peeling for chronic macular edema. Preoperative and postoperative spectral-domain optical coherence tomography (OCT was examined for macular thickness and macular volume. Outcomes and variables were analyzed using the two-tailed t-test and Spearman's rank correlation coefficient.Results: Twenty-four eyes from 11 men and 10 women of mean age 69 (range 55–84 years were included. Four patients (17% had chronic macular edema from uveitis, four (17% from retinal vein occlusion, and 16 (67% from diabetes. Mean visual acuity was 20/103 preoperatively and 20/87 postoperatively (P = 0.55. Sixty-three percent of the eyes had improved vision (47% better than 20/40, 21% maintained the same vision, and 17% had worse vision. Forty-seven percent of improved eyes and 30% of total eyes gained more than two lines of visual acuity (range -9 to +7 lines. Mean macular thickness was 455 µm preoperatively and 396 µm postoperatively (P = 0.29. Mean macular volume was 7.9 mm3 preoperatively and 7.5 mm3 postoperatively (P = 0.51. The strongest predictor of postoperative visual acuity was initial visual acuity (r = 0.673, P = 0.0003.Conclusion: Even though a majority of patients had improved vision and decreased macular thickening after 25-gauge pars plana vitrectomy with internal limiting membrane peeling for chronic macular edema of various etiologies, the difference in visual acuity or macular thickening did not reach statistical significance.Keywords: chronic macular

  8. Workshop on iodine aspects of severe accident management. Summary and conclusions

    Following a recommendation of the OECD Workshop on the Chemistry of Iodine in Reactor Safety held in Wuerenlingen (Switzerland) in June 1996 [Summary and Conclusions of the Workshop, Report NEA/CSNI/R(96)7], the CSNI decided to sponsor a Workshop on Iodine Aspects of Severe Accident Management, and their planned or effective implementation. The starting point for this conclusion was the realization that the consolidation of the accumulated iodine chemistry knowledge into accident management guidelines and procedures remained, to a large extent, to be done. The purpose of the meeting was therefore to help build a bridge between iodine research and the application of its results in nuclear power plants, with particular emphasis on severe accident management. Specifically, the Workshop was expected to answer the following questions: - what is the role of iodine in severe accident management? - what are the needs of the utilities? - how can research fulfill these needs? The Workshop was organized in Vantaa (Helsinki), Finland, from 18 to 20 May 1999, in collaboration with Fortum Engineering Ltd. It was attended by forty-six specialists representing fifteen Member countries and the European Commission. Twenty-eight papers were presented. These included four utility papers, representing the views of Electricite de France (EDF), Teollisuuden Voima Oy and Fortum Engineering Ltd (Finland), the Nuclear Energy Institute (USA), and Japanese utilities. The papers were presented in five sessions: - iodine speciation; - organic compound control; - iodine control; - modeling; - iodine management; A sixth session was devoted to a general discussion on iodine management under severe accident conditions. This report summarizes the content of the papers and the conclusions of the workshop

  9. Specialist meeting on selected containment severe accident management strategies. Summary and conclusions

    The CSNI Specialist Meeting on Selected Containment Severe Accident Management Strategies held in Stockholm, Sweden in June 1994 was organised by the Task Group on Containment Aspects of Severe Accident Management (CAM) of CSNI's Principal Working Group on the Confinement of Accidental Radioactive Releases (PWG4) in collaboration with the Swedish Nuclear Power Inspectorate (SKI). Conclusions and recommendations are given for each of the sessions of the workshops: Containment accident management strategies (general aspects); hydrogen management techniques and other containment accident management techniques; surveillance and protection of containment function

  10. Direct steam generation in parabolic troughs: final results and conclusions of the DISS project

    Zarza, Eduardo; Valenzuela, Loreto; Leon, Javier [CIEMAT-Plataforma Solar de Almeria, Almeria (Spain); Hennecke, Klaus [DLR, Solar Energietechnik, Koeln (Germany); Eck, Markus [DLR, Inst. of Technical Thermodynamics, Stuttgart (Germany); Weyers, H.-Dieter; Eickhoff, Martin [DLR-Plataforma Solar de Almeria, Almeria (Spain)

    2004-05-01

    This paper presents a summary of the main results and conclusions achieved in the DISS (DIrect Solar Steam) project. The test facility implemented at the Plataforma Solar de Almeria (PSA) in 1997-8, the so-called PSA DISS test facility, was operated for more than 3000 h in 1999-2000 and 2001 to investigate the Direct Steam Generation (DSG) process under real solar conditions. The feasibility of the DSG process in horizontal parabolic trough collectors has been proven and an important know how has been acquired by the project partners regarding the thermo-hydraulic parameters of the water/steam flow in DSG solar fields. (Author)

  11. Education for childhood obesity prevention across the life-course: workshop conclusions

    Pérez-Escamilla, R; Hospedales, J; Contreras, A; Kac, G

    2013-01-01

    The objectives of this paper are to present the conclusions from the workshop ‘Education for childhood obesity prevention: a life-course approach', coordinated by the Pan-American Health Organization and the Pan-American Health and Education Foundation, and held on 14 June 2012 in Aruba, as part of the II Pan-American Conference on Childhood Obesity (http://www.paco.aw/). This workshop focused on the need to recognize the life-course framework and education as a social determinant of health t...

  12. L'offre dans la conclusion du contrat en droit civil européen

    Campi, Arnaud

    2011-01-01

    La notion d’offre peut assurément être considérée comme la pierre angulaire du mécanisme de conclusion du contrat en Droit civil européen. En effet, hormis quelques divergences relevant de choix systématiques, il convient de noter que les législations nationales comme le Code civil français de 1804 ou le Code des obligations suisse de 1911 tout comme les textes internationaux tels les Principes Unidroit, la Convention de Vienne sur la vente internationale de marchandises, les Principes de Dro...

  13. Conclusions and recommendations of the international expert symposium in Fukushima nuclear disaster

    The International Expert Symposium in Fukushima: Radiation and Health Risks met in Fukushima, Japan, on September 11 and 12, 2011. The purpose of the symposium was for a group of international and Japanese experts in radiation and health-related fields to review the potential health effects of radiation from the Fukushima nuclear accident. The symposium participants took note of the wide global experience available for assessing the consequences of major releases of radioactive substances into the environment and reached some conclusions and recommendations about radiation and health risks after Fukushima nuclear accident. (authors)

  14. Monitoreo de parásitos en efluentes domiciliarios

    Liliana Semenas; Norma Brugni; Gustavo Viozzi; Ana Kreiter

    1999-01-01

    OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente ...

  15. Inspecciones París MOU y normas reguladoras

    Díaz Pujol, María del Carmen

    2013-01-01

    Este proyecto trata fundamentalmente del control del Estado rector del puerto que desarrollan los Estados miembros del Memorando de París. El texto se compone de cinco capítulos a lo largo de los que se abordan las siguientes cuestiones: El capítulo primero da un repaso a la importancia que revisten las normas sobre seguridad marítima y prevención de la contaminación marina, a la vez que expone la cuestión relativa a la responsabilidad de su aplicación y de su cumplimiento, recordando q...

  16. Alex: incluir la parálisis cerebral

    Ayuela Fernández, Mª del Mar

    2013-01-01

    El presente trabajo se basa en un estudio de caso: Alex. Un niño con una parálisis cerebral tipo espástico y su inclusión, bajo el proceso de enseñanza-aprendizaje durante el curso 2012-2013 en dos escenarios: familia y colegio. En un primer momento señalaremos los objetivos planteados a raíz de los interrogantes que nos suscita el trabajar con niños y niñas con necesidades educativas especiales. Posteriormente y tras un encuadre teórico y metodológico, abordaremos una propuesta de intervenci...

  17. Videojuego adaptado para personas con parálisis cerebral

    Gómez Davó, Roberto

    2014-01-01

    La parálisis cerebral describe un grupo de trastornos del desarrollo psicomotor, que causan una limitación de la actividad de la persona, es decir, es un padecimiento que principalmente se caracteriza por la inhabilidad de poder controlar completamente las funciones del sistema motor. Esto puede incluir espasmos o rigidez en los músculos, movimientos involuntarios, y/o trastornos en la postura o movilidad del cuerpo. Estos trastornos psicomotores imposibilitan su interacción con los sistemas ...

  18. INCORPORATION DU PHOSPHORE DANS CdTe PAR RECUIT LASER

    Uzan, C.; Legros, R.; Marfaing, Y.

    1983-01-01

    La méthode du recuit laser a été utilisée pour incorporer du phosphore dans CdTe à partir d'une couche de Cd3P2 déposée en surface. La caractérisation par photoluminescence et mesure de profil à l'analyseur ionique montre le caractère actif du phosphore introduit et permet d'évaluer à 1018cm-3 la concentration atteinte à 1 µm de profondeur.

  19. INNOVATIONS ET GOUVERNANCE TERRITORIALE : UNE ANALYSE PAR LES DISPOSITIFS

    Soulard, Christophe-Toussaint; Mathé, Syndhia; Michel, Laura; Nougaredes, Brigitte; Jarrige, Françoise; Maurel, Pierre; Clement, Camille; Martinand, Pierre; Guiheneuf, Pierre-Yves; Barbe, Eric

    2010-01-01

    Cette communication vise à présenter les outils méthodologiques d’analyse/évaluation de la gouvernance territoriale élaborés dans le cadre du projet de recherche PSDR Gouv.Innov sur les innovations organisationnelles relatives à la gouvernance territoriale. Il s’agit d’étudier les transformations introduites par les politiques de développement durable au niveau des dispositifs de gouvernance territoriale visant à favoriser une gestion intégrée des espaces ruraux. Dans un contexte de recomposi...

  20. Innovation et gouvernance territoriale : une analyse par les dispositifs

    Rey Valette, H.; Chia, E; Soulard, C.; Mathé, S.; Michel, L.; Nougaredes, B.; Jarrige, F.; Maurel, P.; Clement, C.; Martinand, P.; Guiheneuf, P.Y.; Barbe, E.

    2010-01-01

    International audience Cette communication vise à présenter les outils méthodologiques d'analyse/évaluation de la gouvernance territoriale élaborés dans le cadre du projet de recherche PSDR Gouv.Innov sur les innovations organisationnelles relatives à la gouvernance territoriale. Il s'agit d'étudier les transformations introduites par les politiques de développement durable au niveau des dispositifs de gouvernance territoriale visant à favoriser une gestion intégrée des espaces ruraux. Dan...

  1. In vitro Quinolones Susceptibility Analysis of Chinese Mycoplasma bovis Isolates and their Phylogenetic Scenarios based upon QRDRs of DNA Topoisomerases Revealing a Unique Transition in ParC

    Riaz Mustafa1,2,3, Jingjing Qi1,2, Xiaoliang Ba1,2, Yingyu Chen1,4, Changmin Hu1,2, Xiaole Liu1,2, Lingling Tu5, Qingjie Peng5, Huanchun Chen1,2 and Aizhen Guo1,2*

    2013-07-01

    Full Text Available Mycoplasma bovis can cause different systemic problems in cattle, and recently has been resulted in huge economic losses in China. In vitro susceptibilities of 26 twice sub-cultured Chinese M. bovis field isolates were determined at physiological pH including PG45 through broth micro-dilution method. Except Huanggang isolate, all isolates and PG45 were in the sensitive range for levofloxacin, lomefloxacin and ciprofloxacin, whereas, for norfloxacin and nalidixic acid, they had shown intermediate resistant and complete resistant patterns, respectively. The multiple sequence analysis revealed point mutations in QRDRs of gyrA and parC genes of Huanggang isolate resulting in amino acid substitutions at positions 83 (S-F in GyrA (E. coli numbering and 80 (S-I in ParC proteins, the latter is reported for first time in M. bovis. Conclusively, fluoroquinolones are the potential veterinary therapeutic agents for mycoplasmosis in China and resistance to these agents comes through point mutations in QRDRs of gyrA and parC genes with ParC and GyrA mutation orientation.

  2. Summary of the presentations and conclusions from Bio Dose - 2008, September 7 - 10, 2008

    Full text: The purpose of this presentation is to provide a summary of the content and conclusions from the recent international meeting on bio-dosimetry held at Dartmouth Medical School in September 2008. The presentation will be made by the President of the conference. It is anticipated that this information will complement the presentations and discussions on related topics that will occur during IRPA 12. This meeting, the third in a series, was held with the sponsorship of several national and international agencies. These conferences are focused on bio-dosimetry for both triage for clinically significant exposures to ionizing radiation in the aftermath of an incident in which a large population is potentially exposed and for long term retrospective dosimetry for potential long term effects from such exposures. The invited and offered presentations cover the entire range of techniques based on biological dosimetry, with particularly extensive coverage of methods based on cytogenetics, alterations in DNA, and EPR-based techniques. The presentation will summarize the highlights of the scientific presentations and the conclusions drawn at the end of the conference from panel discussions. (author)

  3. Broken Robustness Analysis: How to make proper climate change conclusions in contradictory multimodal measurement contexts.

    Keyser, V.

    2015-12-01

    Philosophers of science discuss how multiple modes of measurement can generate evidence for the existence and character of a phenomenon (Horwich 1982; Hacking 1983; Franklin and Howson 1984; Collins 1985; Sober 1989; Trout 1993; Culp 1995; Keeley 2002; Staley 2004; Weber 2005; Keyser 2012). But how can this work systematically in climate change measurement? Additionally, what conclusions can scientists and policy-makers draw when different modes of measurement fail to be robust by producing contradictory results? First, I present a new technical account of robust measurement (RAMP) that focuses on the physical independence of measurement processes. I detail how physically independent measurement processes "check each other's results." (This account is in contrast to philosophical accounts of robustness analysis that focus on independent model assumptions or independent measurement products or results.) Second, I present a puzzle about contradictory and divergent climate change measures, which has consistently re-emerged in climate measurement. This discussion will focus on land, drilling, troposphere, and computer simulation measures. Third, to systematically solve this climate measurement puzzle, I use RAMP in the context of drought measurement in order to generate a classification of measurement processes. Here, I discuss how multimodal precipitation measures—e.g., measures of precipitation deficit like the Standard Precipitation Index vs. air humidity measures like the Standardized Relative Humidity Index--can help with the classification scheme of climate change measurement processes. Finally, I discuss how this classification of measures can help scientists and policy-makers draw effective conclusions in contradictory multimodal climate change measurement contexts.

  4. Attaining and maintaining a continuity of knowledge to draw safeguards conclusions with confidence

    As the 21. century progresses, new nuclear facilities and the expansion of nuclear activities into new countries will require the International Atomic Energy Agency (IAEA) to place a higher reliance on attaining and maintaining a Continuity of Knowledge (CoK) of its safeguards information than is currently practiced. Additionally, a conceptual view of where and how CoK can be applied will need to evolve to support improved efficiency and efficacy of drawing a safeguards conclusion for each Member State. The ability to draw a safeguards conclusion for a Member State will be predicated on the confidence that CoK has been attained and subsequently maintained with respect to the data and information streams used by the IAEA. This confidence can be described as a function of factors such as elapsed time since the measurement, surveillance of attributes, authentication of information, historic knowledge of potential system failures, and the number and type of data collections. A set of general scenarios are described for determining what is required to attain CoK and whether CoK has been maintained. A high‑level analysis of example scenarios is presented to identify failures or gaps that could cause a loss of CoK. Potential areas for technological research and development are discussed for the next generation of CoK tools.

  5. Surgical results of combined pars plana vitrectomy and phacoemulsification for vitreous hemorrhage in PDR

    Canan H

    2013-08-01

    Full Text Available Handan Canan,1 Selçuk Sizmaz,2 Rana Altan-Yaycioğlu1 1Department of Ophthalmology, Adana Teaching and Medical Research Center, Baskent University School of Medicine, 2Department of Ophthalmology, Cukurova University School of Medicine, Yuregir, Adana, Turkey Background: The purpose of this study was to evaluate the effectiveness, safety, and incidence of complications after combined clear corneal phacoemulsification with intraocular lens implantation and pars plana vitrectomy in eyes with proliferative diabetic retinopathy coexistent with significant cataract. Methods: Eighty-five eyes of 85 patients with proliferative diabetic retinopathy underwent primary standard three-port vitrectomy with 20-gauge instruments and phacoemulsification with intraocular lens implantation for vitreous hemorrhage from 2008 to 2011. The main outcome measures were visual outcomes and surgical complications. Results: Forty patients were male and 45 were female. Their age ranged from 40 to 77 years with a mean of 59.6 years. The mean follow-up was 13 months, with a range of 6–48 months. The preoperative logMAR visual acuity changed from 2.62 ± 0.6 to 0.8 ± 0.7 postoperatively. Postoperatively, visual acuity improved in 79 eyes (92.9%, and did not change in six eyes (7.1%. Intraoperative complications were transient corneal edema (five eyes and posterior capsular rupture (one eye. Postoperative complications consisted of transient intraocular pressure elevation (25 eyes, corneal epithelial defects (six eyes, anterior chamber reaction (four eyes, hyphema (two eyes, posterior synechiae (four eyes, vitreous hemorrhage (23 eyes, retinal tears (five eyes, retinal detachment (one eye, and neovascular glaucoma (one eye. Conclusion: Our study suggests that the combined operation of pars plana vitrectomy, phacoemulsification, and intraocular lens implantation is safe and effective for patients with proliferative diabetic retinopathy. We believe that the visual outcome and

  6. The double par locus of virulence factor pB171: DNA segregation is correlated with oscillation of ParA

    Ebersbach, G; Gerdes, K; Charbon, Gitte Ebersbach

    2001-01-01

    Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All ...... simultaneously abolished plasmid stabilization and ParA-Gfp oscillation. These observations raise the possibility that ParA oscillation is prerequisite for active plasmid segregation.......Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All...... Type II locus. Separately, each locus stabilized a test-plasmid efficiently. Together, the two loci mediated even more efficient plasmid stabilization. The par loci have a unique genetic organization in that they share a common central region at which the two different DNA-binding proteins probably act...

  7. DOE CALiPER Program, Report 20.1 Subjective Evaluation of Beam Quality, Shadow Quality, and Color Quality for LED PAR38 Lamps

    Royer, Michael P.; Poplawski, Michael E.; Miller, Naomi J.

    2013-10-01

    This report focuses on human-evaluated characteristics, including beam quality, shadow quality, and color quality. Using a questionnaire that included rank ordering, opinions on 27 of the Report 20 PAR38 lamps were gathered during a demonstration event for members of the local Illuminating Engineering Society (IES) chapter. This was not a rigorous scientific experiment, and the data should not be extrapolated beyond the scope of the demonstration. The results suggest that many of the LED products compared favorably to halogen PAR38 benchmarks in all attributes considered. LED lamps using a single-emitter design were generally preferred for their beam quality and shadow quality, and the IES members ranking of color quality did not always match the rank according to the color rendering index (CRI).

  8. CALiPER Report 20.1: Subjective Evaluation of Beam Quality, Shadow Quality, and Color Quality for LED PAR38 Lamps

    None, None

    2013-11-07

    This report focuses on human-evaluated characteristics, including beam quality, shadow quality, and color quality. Using a questionnaire that included rank-ordering, opinions on 27 of the Report 20 PAR38 lamps were gathered during a demonstration event for members of the local Illuminating Engineering Society (IES) chapter. This was not a rigorous scientific experiment, and the data should not be extrapolated beyond the scope of the demonstration. The results suggest that many of the LED products compared favorably to halogen PAR38 benchmarks in all attributes considered. LED lamps using a single-emitter design were generally preferred for their beam quality and shadow quality, and the IES members' ranking of color quality did not always match the rank according to the color rendering index (CRI).

  9. Localization of the ParC protein in Escherichia coli cells

    2007-01-01

    The Escherichia coli ParC protein is one of two subunits of the topoisomerase IV, a type II topoisomerase. Topo IV is responsible for relaxing positive supercoils and decatenating linked daughter chromosomes after replication. This is done by introducing transient double-stranded breaks into the DNA, passing through a segment of uncut duplex DNA, before resealing the break. Mutations in parC lead to the par phenotype which is characterized by chromosomes that can replicate but are deficient i...

  10. Investigations of aircrews exposure to cosmic radiation - results, conclusions and suggestions

    Bilski, P; Horwacik, T; Marczewska, B; Ochab, E; Olko, P

    2002-01-01

    In frame of a research project undertaken in collaboration with Polish airlines LOT, analysis of aircrews exposure to cosmic radiation has been performed. The applied methods included measurements of radiation doses with thermoluminescent detectors (MTS-N, MCP-N) and track detectors (CR-39) and also calculations of route doses with the CARI computer code. The obtained results indicate that aircrews of nearly all airplanes, with exception of these flying only on ATR aircraft, exceed regularly or may exceed in some conditions, effective doses of 1 mSv. In case of Boeing-767 aircrews such exceeding occurs always, independently of solar activity. Investigations revealed, that during these periods of the solar cycle, when intensity of cosmic radiation is high, exceeding of 6 mSv level is also possible. These results indicate, that according to Polish and European regulations it is necessary for airlines to provide regular estimations of radiation exposure of aircrews. Basing on the obtained results a system for pe...

  11. Investigations of aircrews exposure to cosmic radiation - results, conclusions and suggestions

    In frame of a research project undertaken in collaboration with Polish airlines LOT, analysis of aircrews exposure to cosmic radiation has been performed. The applied methods included measurements of radiation doses with thermoluminescent detectors (MTS-N, MCP-N) and track detectors (CR-39) and also calculations of route doses with the CARI computer code. The obtained results indicate that aircrews of nearly all airplanes, with exception of these flying only on ATR aircraft, exceed regularly or may exceed in some conditions, effective doses of 1 mSv. In case of Boeing-767 aircrews such exceeding occurs always, independently of solar activity. Investigations revealed, that during these periods of the solar cycle, when intensity of cosmic radiation is high, exceeding of 6 mSv level is also possible. These results indicate, that according to Polish and European regulations it is necessary for airlines to provide regular estimations of radiation exposure of aircrews. Basing on the obtained results a system for performing such estimations has been proposed. (author)

  12. Main Results and Conclusions of Probabilistic Safety Analysis (PSA) Level 1 for Units 5 and 6 of ''Kozloduy'' NPP

    In accordance with international practice, probabilistic safety analysis (PSA) is an established tool for studying the main risk aspects of the design and operation, to explore the importance of plant modifications and evaluation of events plant experience. Different PSA applications are very useful and flexible tool in addition to deterministic analysis. PSA can be used to optimize the different plant configurations, for justification or basis for modification of limiting conditions for operation (LCO), for planning of maintenance activities, to provide engineering evaluations in decisions making process as well as to control and monitoring the safety. This paper presents the main results and conclusions from the last update of PSA level 1 for 5 and 6 units of ''Kozloduy'' NPP. This study shows the measures of ''modernization program'' 5 and 6 units of ''Kozloduy'' NPP, realized in the period 2001-2007. PSA level 1 is performed by the team of Risk Engineering. This paper shows the main contributors to the risk. The results for internal initiating events, earthquakes, internal flooding and internal fires are given.(author).

  13. Utilisation rationnelle de l'énergie par les techniques de stockage et de transport du froid par chaleur latente

    Bédécarrats, Jean-Pierre

    2010-01-01

    Les contraintes environnementales de plus en plus fortes ainsi que les problèmes grandissants de la disponibilité des ressources énergétiques obligent le secteur de l'énergie non seulement à une évolution importante de ses technologies mais aussi à leurs utilisations plus rationnelles. Ce mémoire présente la synthèse de mes initiatives de recherches menées sur le stockage et le transport de l'énergie par chaleur latente essentiellement dans le domaine du froid. Les Matériaux à Changement de P...

  14. The six most essential questions in psychiatric diagnosis: a pluralogue. Part 4: general conclusion

    Phillips James

    2012-12-01

    Full Text Available Abstract In the conclusion to this multi-part article I first review the discussions carried out around the six essential questions in psychiatric diagnosis – the position taken by Allen Frances on each question, the commentaries on the respective question along with Frances’ responses to the commentaries, and my own view of the multiple discussions. In this review I emphasize that the core question is the first – what is the nature of psychiatric illness – and that in some manner all further questions follow from the first. Following this review I attempt to move the discussion forward, addressing the first question from the perspectives of natural kind analysis and complexity analysis. This reflection leads toward a view of psychiatric disorders – and future nosologies – as far more complex and uncertain than we have imagined.

  15. Incorrect statistical method in parallel-groups RCT led to unsubstantiated conclusions.

    Allison, David B; Antoine, Lisa H; George, Brandon J

    2016-01-01

    The article by Aiso et al. titled "Compared with the intake of commercial vegetable juice, the intake of fresh fruit and komatsuna (Brassica rapa L. var perviridis) juice mixture reduces serum cholesterol in middle-aged men: a randomized controlled pilot study" does not meet the expected standards of Lipids in Health and Disease. Although the article concludes that there are some significant benefits to their komatsuna juice mixture, these claims are not supported by the statistical analyses used. An incorrect procedure was used to compare the differences in two treatment groups over time, and a large number of outcomes were tested without correction; both issues are known to produce high rates of false positives, making the conclusions of the study unjustified. The study also fails to follow published journal standards regarding clinical trial registration and reporting. PMID:27083538

  16. Conclusions and lessons learned [Brazil: A country profile on sustainable energy development

    This study is the first in a series of national studies conducted under a unique partnership initiative officially registered with the United Nations Commission on Sustainable Development by the IAEA, in cooperation with participating Brazilian organizations and the United Nations Department of Economic and Social Affairs (UNDESA). Similar studies for South Africa and Cuba, modelled after this study, are expected to be completed in 2006. This chapter presents the main conclusions derived from this comprehensive assessment of the Brazilian energy system performed within a sustainable development framework. The chapter also outlines 'other accomplishments' of and 'lessons learned' from the cooperative effort conducted jointly by Brazilian and international experts. It concludes with some reflections about 'next steps' that may be followed to continue advancing the concepts and ideas supporting sustainable development at the national and international levels

  17. Status of maintenance in the US nuclear power industry 1985. Volume 1. Findings and conclusions

    This report presents the findings, conclusions and recommendations derived from activities performed under Phase I of the NRC Maintenance and Surveillance Program (MSP). Findings are based on trends and patterns derived from operational data compiled by the NRC for the period 1980 through 1985, site surveys conducted at eight plants, and questionnaires administered to NRC Resident Inspectors to characterize nuclear power plant maintenance programs and practices. These activities have shown that plant maintenance programs and practices are highly variable from plant-to-plant and are currently undergoing major changes. While measured plant performance has improved overall since 1980, the maintenance-related contribution to reportable events and challenges to safety systems remains high and is increasing by some measures. The findings of Phase I of the MSP confirmed a number of problems in nuclear power plant maintenance which warrant further NRC and industry attention

  18. Gasification of waste. Summary and conclusions of twenty-five years of development

    Rensfelt, Erik [TPS Termiska Processer AB, Nykoeping (Sweden); Oestman, Anders [Kemiinformation AB, Stockholm (Sweden)

    2000-04-01

    An overview of nearly thirty years development of waste gasification and pyrolysis technology is given, and some major general conclusions are drawn. The aim has been to give new developers an overview of earlier major attempts to treat MSW/RDF with thermochemical processes, gasification or pyrolysis. Research work in general is not covered, only R and D efforts that have led to substantial testing in pilot scale or demonstration. For further details, especially related to ongoing R and D, readers are referred to other recent reviews. The authors' view is that gasification of RDF with appropriate gas cleaning can play an important role in the future, for environmentally acceptable and efficient energy production. A prerequisite is that some of the major mistakes can be avoided, such as: (1) too rapid scale-up without experimental base, (2) unsuitable pretreatment of MSW to RDF and poor integration with material recycling, and (3) too limited gas/flue gas cleaning.

  19. Remotely and Conclusively Mapping One Finite Set of Qudit States onto Another Assisted by Qubit Entanglements

    Chen, Li-Bing; Lu, Hong

    2016-05-01

    Alice and Bob are two remote parties. We propose a probabilistic method which allows Alice to map remotely and conclusively Bob's set of nonorthogonal symmetric d-level quantum states onto another. The procedure we use is a remote positive operator valued measurement (POVM) in Bob's (2 d-1)-level direct sum space. We construct a quantum network for implementing this (2 d-1)-level remote nonunitary POVM with ( d-1) two-level remote unitary rotations. The fact that the two-level remote rotation, which is hired to rotate remotely a basis vector, can been implementing rapidly using only one ebit (a two-level Einstein-Podolsky-Rosen (EPR) pair) and one cbit (classical communication) is notable. This scheme is simpler but with less resource, which will make it more feasible and suitable for large-scale quantum network.

  20. The international INTRAVAL project. Summary and conclusions by the TVO/VTT Team

    Teollisuuden Voima Oy (TVO) participated the international cooperation project INTRAVAL and VTT Energy acted as a project team. The Finnish participation focused on flow and transport in crystalline fractured rock and six test cases out of thirteen were tackled. The experimental results were evaluated mainly by means of analytical transport models. The report presents a short review of the experience obtained in the course of the project. It concentrates on the issues revealed in the discussions and analyses of the six test cases in which the TVO/VTT team actively participated but some of the conclusions are even more general in nature. Some suggestions are made for future experimental and theoretical work in the field of geosphere. (15 refs., 2 tabs.)

  1. Space debris removal by ground-based lasers: main conclusions of the European project CLEANSPACE.

    Esmiller, Bruno; Jacquelard, Christophe; Eckel, Hans-Albert; Wnuk, Edwin

    2014-11-01

    Studies show that the number of debris in low Earth orbit is exponentially growing despite future debris release mitigation measures considered. Specifically, the already existing population of small and medium debris (between 1 cm and several dozens of cm) is today a concrete threat to operational satellites. A ground-based laser solution which can remove, at low expense and in a nondestructive way, hazardous debris around selected space assets appears as a highly promising answer. This solution is studied within the framework of the CLEANSPACE project which is part of the FP7 space program. The overall CLEANSPACE objective is: to propose an efficient and affordable global system architecture, to tackle safety regulation aspects, political implications and future collaborations, to develop affordable technological bricks, and to establish a roadmap for the development and the future implantation of a fully functional laser protection system. This paper will present the main conclusions of the CLEANSPACE project. PMID:25402937

  2. Stress reactions involving the pars interarticularis in young athletes

    A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated

  3. The 2015 Dietary Guidelines Advisory Committee Scientific Report: Development and Major Conclusions.

    Millen, Barbara E; Abrams, Steve; Adams-Campbell, Lucile; Anderson, Cheryl Am; Brenna, J Thomas; Campbell, Wayne W; Clinton, Steven; Hu, Frank; Nelson, Miriam; Neuhouser, Marian L; Perez-Escamilla, Rafael; Siega-Riz, Anna Maria; Story, Mary; Lichtenstein, Alice H

    2016-05-01

    The Dietary Guidelines for Americans (DGA) is published every 5 y jointly by the Department of Health and Human Services (HHS) and the USDA and provides a framework for US-based food and nutrition programs, health promotion and disease prevention initiatives, and research priorities. Summarized in this report are the methods, major conclusions, and recommendations of the Scientific Report of the 2015 US Dietary Guidelines Advisory Committee (DGAC). Early in the process, the DGAC developed a conceptual model and formulated questions to examine nutritional risk and determinants and impact of dietary patterns in relation to numerous health outcomes among individuals aged ≥2 y. As detailed in the report, an expansive, transparent, and comprehensive process was used to address each question, with multiple opportunities for public input included. Consensus was reached on all DGAC's findings, including each conclusion and recommendation, and the entire report. When research questions were answered by original systematic literature reviews and/or with existing, high-quality expert reports, the quality and strength of the evidence was formally graded. The report was organized around the following 5 themes: 1) food and nutrient intakes and health: current status and trends; 2) dietary patterns, foods and nutrients, and health outcomes; 3) diet and physical activity behavior change; 4) food and physical activity environments; and 5) food sustainability and food safety. The following 3 cross-cutting topics were addressed: 1) sodium, 2) saturated fat, and 3) added sugars. Physical activity recommendations from recent expert reports were endorsed. The overall quality of the American diet was assessed to identify overconsumed and underconsumed nutrients of public health concern. Common food characteristics of healthy dietary patterns were determined. Features of effective interventions to change individual and population diet and physical activity behaviors in clinical, public

  4. Conclusion on the peer review of the pesticide risk assessment of the active substance sulfoxaflor

    European Food Safety Authority

    2014-05-01

    Full Text Available The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State Ireland and the co-rapporteur Member States Czech Republic, France and Poland for the pesticide active substance sulfoxaflor and the assessment of applications for maximum residue levels (MRLs are reported. The context of the peer review was that required by Regulation (EC No 1107/2009 of the European Parliament and of the Council. The conclusions were reached on the basis of the evaluation of the representative uses of sulfoxaflor as an insecticide on fruiting vegetables (field use and glasshouse application; tomato, cherry tomato, pepper (bell and non bell, aubergine, cucurbits (field use and glasshouse application; cucumber, water melon, courgette, spring and winter cereals (wheat, rye, barley, oats, triticale and cotton. MRLs were assessed in almonds, pecans, apples, pears, cherries, peaches including nectarines, apricots, plums, wheat and barley grain, broccoli, cauliflower, mustard greens, cabbage, leaf and head lettuce, spinach, celery, cotton seed, oilseed rape seed, grapefruit, lemons, oranges, melons, squash (winter and summer, cucumbers, potatoes, sugar beet, carrots, soya bean, beans (pulses, fresh beans with and without pods, strawberries, tomatoes, peppers, wine and table grapes, and in animal commodities such as milk, eggs, muscle, fat, liver and kidney. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment and the proposed MRLs, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed. With the available assessments a high risk to bees was not excluded for field uses and a high long-term risk was indicated for the small herbivorous mammal scenario for field uses in vegetables and in

  5. Urokinase-type plasminogen activator receptor (uPAR) as a promising new imaging target

    Persson, Morten; Kjaer, Andreas

    2013-01-01

    Urokinase-type plasminogen activator receptor (uPAR) has been shown to be of special importance during cancer invasion and metastasis. However, currently, tissue samples are needed for measurement of uPAR expression limiting the potential as a clinical routine. Therefore, non-invasive methods are...... the cell surface. Due to the importance of uPAR in cancer invasion and metastasis, a number of high-affinity ligands have been identified during the last decades. These ligands have recently been used as starting point for the development of a number of ligands for imaging of uPAR using various...

  6. Structural and genetic analyses of a par locus that regulates plasmid partition in Bacillus subtilis.

    Chang, S.; Chang, S Y; Gray, O

    1987-01-01

    The Bacillus plasmid pLS11 partitions faithfully during cell division. Using a partition-deficient plasmid vector, we randomly cloned DNA fragments of plasmid pLS11 and identified the locus that regulates plasmid partition (par) by cis complementation in Bacillus subtilis. The cloned par gene conferred upon the vector plasmid a high degree of segregational stability. The par locus was mapped to a 167-base-pair segment on pLS11, and its nucleotide sequence was determined. The cloned par fragme...

  7. Conclusion of the EU nuclear stress test. Comments on results and interpretations

    On 4th October 2012 the European Commission had published their interpretation of the results of the EU Nuclear Stress Test for the nuclear power stations in the individual EU Member States and in Switzerland and the Ukraine, the neighbouring states involved. According to this, the safety standards in nuclear power stations are generally high. None of the plants inspected revealed shortcomings in design, which would have required the service to be interrupted or the decommissioning of the plant. This means inter alia that there are no shortcomings in design in Europe like those in Fukushima Daiichi in Japan. To summarise, it can be stated that, in the opinion of the country-specific peer assessments, or peer reviews, the respective national investigations and the EU Stress Test have demonstrated that (a) the safety standards in all the European nuclear power stations are generally high and deactivation is not necessary, (b) in all plants the design principles (inter alia seismic intensity, level of floodwater, external pressures) have been correctly defined for each location (cause of the disaster at Fukushima), (c) evidence for the management of all the respective requirements do not merely exist, but are also correct, (d) furthermore, the plants demonstrate to a varying extent additional reserves or robustness as regards incidents which exceed the technical specifications. There is no question of the 'severe shortcomings' claimed by the daily newspaper, Die Welt, a few days before the publication of the EU Stress Test results. What is more relevant is that the Commission Report on the EU Stress Test made only two recommendations for the German nuclear power stations. (orig.)

  8. Estudo sobre o melhoramento da laranja "Baía" III: Conclusão

    F. G. Brieger

    1941-09-01

    Full Text Available 1. The present paper represents the final report of the experiment about the constancy in a clon of the orange "Baianinha" which has been studied during the past four years. 2. The trees were obtained by grafting buds taken from one tree, 17-2, of the "Asilo" in Piracicaba, on non-selected seedling root stock of sour orange. 3. The fruits were collected separately for each tree and their diameter (in mm determined. The test "within-between" showed clearly that the variation between the means of trees and within trees are of a totally different order, the former being about 10 times bigger than the latter. 4. Thus it was necessary to use other tests in order to be able to find out whether the trees form a uniform sample or not. A X²-test was carried out for the mean diameters of the 217 trees included in the experiment in 1937 and demonstrated the existence of an accentuated heterogeneity. The same method however could not be applied in the analysis of later years in view of the reduced number of trees. It was necessary therefore to device another test for the data of these years with 44 or 43 trees each only. In carrying out this "test of seguence" the mean diameters were arranged according to their magnitude and were given accordingly numbers of order. The probability was then calculated with which a tree may obtain by chance and in successive years such numbers of order as registered (quadro V. Fuller details are given in the test of this paper and shall be published elsewhere as well. The results of this test were in accordance with those obtained with the X²-test. 5. The trees do not form a uniform sample as explained above. Two types of heterogeneity exist: a The variation between trees is of an entirely different order as the variation within trees, with of 7,2 to 16,5 (guadro III. It may be remembered that ft (Brieger is identical with Vf (Snedecor and e z (Fisher. b The variation between trees is highly heterogeneous as shown by the x2

  9. AN INVESTIGATION OF ADOLESCENTS’ CYBERBULLYING ACCORDING TO SOME VARIABLES

    Mustafa PAMUK

    2013-03-01

    Full Text Available In this reseacrh, adolescents’ cyber-bullying was analysed according to self-compassion, gender and grade levels. Research data was obtained from 169 female, 188 male; totaly 357 adolescents who are curently high school students. In this research, to determine adolescents’ cyber-bullying “the scale of cyber-bullying” was used developed by Arıcak, Kınay ve Tanrıkulu (2011. To determine adolescents’ Self-compassion “the scale of Self-compassion” was used which was adapted to Turkish language by Deniz, Kesici and Sümer.According to research, adolescents’ cyber-bullying does not differ significantly according to self understanding level (F=.158, p>.05 and grade levels (F=2,350, p>.05. According to gender (t= -2,011, p

  10. Limiting enclosures. Classification of enclosures according to their tightness

    A classification of limiting enclosures according to their tightness is given. This can applied to enclosures or series of enclosures intended for work on radioactive products, toxic or dangerous products, materials sensitive to atmospheric components and work in sterile environment

  11. OECD/CSNI Workshop on In-Vessel Core Debris Retention and Coolability - Summary and Conclusions

    In the spring of 1994 an OECD Workshop on Large Pool Heat transfer was held in Grenoble. The scope of this workshop was the investigation of (1) molten pool heat transfer, (2) heat transfer to the surrounding water, and (3) the feasibility of in-vessel core debris cooling through external cooling of the vessel. Since this time, experimental test series have been completed (e.g., COPO, ULPU, CORVIS) and new experimental programs (e.g., BALI, SONATA, RASPLAV, debris and gap heat transfer) have been established to consolidate and expand the data base for further model development and to improve the understanding of in-vessel debris retention and coolability in a nuclear power plant. Discussions within the CSNI's PWG-2 and the Task Group on Degraded Core Cooling (TG-DCC) have led to the conclusion that the time was ripe for organizing a new international Workshop with the objectives: - to review the results of experimental research that has been conducted in this area; - to exchange information on the results of member countries experiments and model development on in-vessel core debris retention and coolability; - to discuss areas where additional experimental research is needed in order to provide an adequate data base for analytical model development for core debris retention and coolability. The scope of this workshop was limited to the phenomena connected to in-vessel core debris retention and coolability and did not include steam explosion and fission product issues. The workshop was structured into the following sessions: Key note papers; Experiments and model development; Debris bed heat transfer; Corium properties, molten pool convection and crust formation; Gap formation and gap cooling; Creep behaviour of reactor pressure vessel lower head; Ex-vessel boiling and critical heat flux phenomena; Scaling to reactor severe accident conditions and reactor applications. Compared to the previous workshop held in Grenoble in 1994, large progress has been made in the

  12. Heterogeneity of asthma according to blood inflammatory patterns.

    Nadif, Rachel; Siroux, Valérie; Oryszczyn, Marie-Pierre; Ravault, Coralie; Pison, Christophe; Pin, Isabelle; Kauffmann, Francine

    2009-01-01

    RATIONALE: There is increasing interest regarding asthma heterogeneity in relation to inflammatory patterns. OBJECTIVES: To assess phenotypic characteristics, in particular clinical presentation of the disease, in 381 well-characterised adults with asthma from the French Epidemiological study on the Genetics and Environment of Asthma (EGEA) according to their blood inflammatory pattern. METHODS: Four blood inflammatory patterns were defined according to eosinophil (EOS) and neutrophil (NEU) c...

  13. The New Basel Capital Accord and Czech Banks

    Jaroslava Bauerová

    2004-01-01

    Commercial-bank risk management is fundamental in determining bank profitability, or indeed bank failure. Capital adequacy is widely considered the final safeguard of a bank?s solvency. Capital adequacy has been regulated chiefly according to the framework put forward by the Basel Committee on Banking Supervision in 1988, this known as the Basel Capital Accord. Since 1991, the committee has published a series of consultative papers toward a new capital-adequacy concept, the so-called New Base...

  14. Risk management and Basel-Accord-implementation in Pakistan

    Omar Masood; John Fry

    2012-01-01

    Purpose – Recent events demonstrate that problems in the banking system pose a significant threat to the health of the global economy. Despite several shortcomings the Basel Accord thus emerges as an attempt to protect banking systems. The purpose of this study is to shed light on potential barriers to implementation of the Basel Accord in emerging countries. Several issues of wider interest to risk management and financial regulation also emerge. Design/methodology/approach – The paper maps ...

  15. Photochromism in V2O5 thin layers produced according to 'sol-gel' technology

    For the first time is reported on the photochromic properties of V2O5 amorphous layers produced according to the 'sol-gel' technology. Absorption spectra are presented of the V2O5 amorphous layers before and after their irradiation by some doses of the mercury-discharge lamp radiation. The obtained results permit make to the conclusion on the prospects of V2O5 gels as photochromic materials

  16. Summary and conclusions of the specialist meeting on severe accident management programme development

    The CSNI Specialist meeting on severe accident management programme development was held in Rome and about seventy experts from thirteen countries attended the meeting. A total of 27 papers were presented in four sessions, covering specific aspects of accident management programme development. It purposely focused on the programmatic aspects of accident management rather than on some of the more complex technical issues associated with accident management strategies. Some of the major observations and conclusions from the meeting are that severe accident management is the ultimate part of the defense in depth concept within the plant. It is function and success oriented, not event oriented, as the aim is to prevent or minimize consequences of severe accidents. There is no guarantee it will always be successful but experts agree that it can reduce the risks significantly. It has to be exercised and the importance of emergency drills has been underlined. The basic structure and major elements of accident management programmes appear to be similar among OECD member countries. Dealing with significant phenomenological uncertainties in establishing accident management programmes continues to be an important issue, especially in confirming the appropriateness of specific accident management strategies

  17. Evaluating Behaviorally Oriented Aviation Maintenance Resource Management (MRM) Training and Programs: Methods, Results, and Conclusions

    Taylor, James C.; Thomas, Robert L., III

    2003-01-01

    Assessment of the impact of Aviation Resource Management Programs on aviation culture and performance has compelled a considerable body of research (Taylor & Robertson, 1995; Taylor, 1998; Taylor & Patankar, 2001). In recent years new methods have been applied to the problem of maintenance error precipitated by factors such as the need for self-assessment of communication and trust. The present study - 2002 -- is an extension of that past work. This research project was designed as the conclusion of a larger effort to help understand, evaluate and validate the impact of Maintenance Resource Management (MRM) training programs, and other MRM interventions on participant attitudes, opinions, behaviors, and ultimately on enhanced safety performance. It includes research and development of evaluation methodology as well as examination of psychological constructs and correlates of maintainer performance. In particular, during 2002, three issues were addressed. First, the evaluation of two (independent & different) MRM programs for changing behaviors was undertaken. In one case we were able to further apply the approach to measuring written communication developed during 2001 (Taylor, 2002; Taylor & Thomas, 2003). Second, the MRM/TOQ surveys were made available for completion on the internet. The responses from these on-line surveys were automatically linked to a results calculator (like the one developed and described in Taylor, 2002) to aid industry users in analyzing and evaluating their local survey data on the internet. Third, the main trends and themes from our research about MRM programs over the past dozen years were reviewed.

  18. Results and Conclusions from the NASA Isokinetic Total Water Content Probe 2009 IRT Test

    Reehorst, Andrew; Brinker, David

    2010-01-01

    The NASA Glenn Research Center has developed and tested a Total Water Content Isokinetic Sampling Probe. Since, by its nature, it is not sensitive to cloud water particle phase nor size, it is particularly attractive to support super-cooled large droplet and high ice water content aircraft icing studies. The instrument comprises the Sampling Probe, Sample Flow Control, and Water Vapor Measurement subsystems. Results and conclusions are presented from probe tests in the NASA Glenn Icing Research Tunnel (IRT) during January and February 2009. The use of reference probe heat and the control of air pressure in the water vapor measurement subsystem are discussed. Several run-time error sources were found to produce identifiable signatures that are presented and discussed. Some of the differences between measured Isokinetic Total Water Content Probe and IRT calibration seems to be caused by tunnel humidification and moisture/ice crystal blow around. Droplet size, airspeed, and liquid water content effects also appear to be present in the IRT calibration. Based upon test results, the authors provide recommendations for future Isokinetic Total Water Content Probe development.

  19. Radiation exposure of children and young adults during X-ray investigations - experience and conclusions

    After discussing the existing regulations for radiation protection of patients in the field of pediatric X-ray diagnostics in the GDR the use of the effective dose equivalent HE and the medium dose equivalent HM for the determination of radiation exposure to children is shortly discussed. Using computer tomography images to determine the position and size of organs of children, and the data from measured depth dose distributions, the exposure related to the entrance dose caused by frequent X-ray examinations was calculated. Measurements of entrance doses at 3 pediatric hospitals for all examination types and the determination of the frequency of X-ray radiographies at 10 hospitals and 10 smaller diagnostic departments were used to calculate the per caput and the collective dose equivalents in the different age groups. Altogether the per caput dose equivalent of the children amounts to approximately 30% of the corresponding value for adults. As a conclusion, the following measures for the further reduction of radiation exposure are proposed: (1) technical measures like fixation of patients, shielding of organs, quality assurance, (2) elaboration of legal regulations, e.g. of a decree on the performance of pediatric X-ray examinations, and (3) training and continued education. Only by these means an appropriate indication (justification) and an efficient reduction of radiation exposure (optimization) can be achieved. (author)

  20. Results and conclusions from the first pressurized-thermal-shock experiment

    Pretest estimates of fracture toughness are reasonably close to the PTSE-1 values. Furthermore, the ASME Sect. XI toughness relationships are conservative relative to actual material characteristics. The experiment demonstrated that arrest toughness substantially above the 220 MPa.√m cutoff of Sect. XI could be realized. The arrest values in PTSE-1 also are consistent with arrest measurements made in wide-plate tests and reported by the Japan Welding Council. The highest PTSE-1 value of arrest occurred at a temperature approx. 30 K above the onset of the Charpy upper shelf. This is believed to be very close to the threshold temperature above which cleavage fracture cannot persist. This result also suggests that the methods of linear elastic fracture mechanics have an important role in fracture evaluation at high (upper-shelf) temperatures. The PTSE-1A and -1B transients were a demonstration that simple warm prestressing (K/sub I/ 0) prevailed during two periods of 40-s and 60-s duration without crack initiation, although K/sub I/ exceeded K/sub Ic/ by 30% to 50%. Clearly simple anti-warm prestressing is not a sufficient condition to alleviate the effects of warm prestressing. A narrow band of ductile tearing formed ahead of the initial cleavage fracture. The conclusions drawn from PTSE-1 suggest that procedures used for evaluating overcooling accidents in pressurized-water reactors should take into consideration realistically the fracture mechanisms that have been clearly demonstrated but not yet generally accepted

  1. Cumulative Instructional Time and Relative Effectiveness Conclusions: Extending Research on Response Intervals, Learning, and Measurement Scale.

    Black, Michelle P; Skinner, Christopher H; Forbes, Bethany E; McCurdy, Merilee; Coleman, Mari Beth; Davis, Kristie; Gettelfinger, Maripat

    2016-03-01

    Adapted alternating treatments designs were used to evaluate three computer-based flashcard reading interventions (1-s, 3-s, or 5-s response intervals) across two students with disabilities. When learning was plotted with cumulative instructional sessions on the horizontal axis, the session-series graphs suggest that the interventions were similarly effective. When the same data were plotted as a function of cumulative instructional seconds, time-series graphs suggest that the 1-s intervention caused the most rapid learning for one student. Discussion focuses on applied implications of comparative effectiveness studies and why measures of cumulative instructional time are needed to identify the most effective intervention(s).Comparative effectiveness studies may not identify the intervention which causes the most rapid learning.Session-series repeated measures are not the same as time-series repeated measures.Measuring the time students spend in each intervention (i.e., cumulative instructional seconds) allows practitioners to identify interventions that enhance learning most rapidly.Student time spent working under interventions is critical for drawing applied conclusions. PMID:27606240

  2. The foundations of reusability: Successful experience and important conclusions from planning and scheduling of space operations

    Hornstein, Rhoda Shaller; Willoughby, J. K.

    1995-01-01

    NASA's Office of Space Communications is sponsoring a combined technical and management initiative to dramatically decrease the cost of preparing for and conducting space operations. The authors present their successful experience and important conclusions from producing generalized and readily reusable solutions and systems for planning and scheduling applications. While generality by itself should enable reuse, generality alone may not produce the desired cost savings. Generality achieved by accumulating numerous special cases within a software system often increases the complexity of the software to the extent that maintenance costs overtake development savings. Because of this phenomenon, the authors have insisted on simplicity, as well as generality, to achieve cost-effective operation reusability. Simplicity and generality can be accomplished simultaneously when the basic 'Building Blocks' for a problem domain, in this paper, planning and scheduling, are discovered and implemented with reuse in mind. The Building Blocks for planning and scheduling are described. The authors also present examples of how these Building Blocks have accommodated various scenarios that were previously treated as mission-peculiar. Two case histories are presented to demonstrate operational reusability and cost effectiveness.

  3. Micah 7:8-20: An apt conclusion to the book of Micah

    W J Wessels

    2003-10-01

    Full Text Available It is argued in this article that Micah 7:8-20 forms an apt conclusion to the book of Micah. As was the case with Micah 1, the concluding section also focusses on Yahweh and his dealings with the people of the earth. There is a universal tendency to be detected in this section as well. An important aspect to notice� is� the liturgical nature of chapters six and seven, especially 7:8-20. There is a vagueness, almost a timelessness, imbuing this section. This could be intended allowing later generations of believers to apply these words to� their� own� circumstances. With Micah 7:8-20 as the concluding section of the book, one is left with a sense of well-roundedness, of completeness. The collection of oracles attributed� to Micah in general has a sombre tone. For this very reason Micah� 7:8-20� seems� to� change� the mood. It breathes hope into a negative atmosphere of judgment. It ends with a strong emphasis on the power of Yahweh, the power of forgiveness.

  4. A fine-grained analysis of the jumping-to-conclusions bias in schizophrenia

    Steffen Moritz

    2009-12-01

    Full Text Available Impaired decision behavior has been repeatedly observed in schizophrenia patients. We investigated several cognitive mechanisms that might contribute to the jumping-to-conclusions bias (JTC seen in schizophrenia patients: biases in information-gathering, information weighting and integration, and overconfidence, using the process tracing paradigm Mouselab. Mouselab allows for an in-depth exploration of various decision-making processes in a structured information environment. A total of 37 schizophrenia patients and 30 healthy controls participated in the experiment. Although showing less focused and systematic information search, schizophrenia patients practically considered all pieces of information and showed no JTC in the sense of collecting less pieces of evidence. Choices of patients and controls both approximated a rational solution quite well, but patients showed more extreme confidence ratings. Both groups mainly used weighted additive decision strategies for information integration and only a small proportion relied on simple heuristics. Under high stress induced by affective valence plus time pressure, however, schizophrenia patients switched to equal weighting strategies: less valid cues and more valid ones were weighted equally.

  5. Summary and conclusions of the NNWSI area-to-location screening activity

    A comprehensive system study has been performed to screen the Nevada Research and Development Area (NRDA) of the Nevada Test Site (NTS) and nearby areas for relatively favorable locations of about ten square miles for the permanent disposal of radioactive waste in a mined repository. The purpose of this screening is to use available information to identify such locations. The results of this screening will allow more informed decisions as to where future repository exploration can be concentrated to optimize the chances that the locations chosen for characterization will actually qualify as a licensed repository site. The screening was conducted in a manner compatible with the general repository siting strategy of the DOE National Waste Terminal Storage Program (NWTS). This report has four chapters. Chapter 1 provides background information regarding the NNWSI screening activity and its relationship to the national program. Chapter 2 describes the systems method used for quantitative evaluation of various locations and rock types in the screening area. It includes definitions of specific screening parameters and descriptions of the mathematical equations for calculating ratings for various locations and host rocks. Chapter 3 presents selected results of the numerical analyses. It shows and describes maps of location ratings and lists of saturated and unsaturated host-rock ratings. Chapter 4 summarizes the results and presents conclusions about which locations and rock types are most favorable. Appendices A through C contain supporting information for the discussions in the text

  6. Medicinal use of potato-derived products: conclusions of a rapid versus full systematic review.

    Van de Velde, Stijn; De Buck, Emmy; Dieltjens, Tessa; Aertgeerts, Bert

    2011-05-01

    Vlachojannis et al reported a systematic review on the medicinal use of potato-derived products. The authors identified five trials for inclusion in the review, including one study on the treatment of burns. Based on this RCT the review authors concluded that potato peel is not recommended for burns. As the authors of a rapid review on the use of potato peels for burns, we read this systematic review with great interest. Although the concept of rapid review is rising, accelerating the review process might introduce bias and its conclusions may be subject to change once a systematic review is available. Since this rapid and systematic review were done at similar times, we explored if the results were consistent. We identified three trials on the use of potato peels. Two of these trials were not mentioned in the systematic review. The evidence indicates that sterile potato peel dressings are better than gauze alone during the healing phase.While there is no evidence of an antibacterial effect, we concluded that potato peels promote healing. Potato peel dressings might be the best available dressing in resource poor countries. Because systematic reviews have a major impact it is crucial that systematic reviews meet specified quality criteria. Therefore we draw attention to adherance to the PRISMA statement. PMID:21110396

  7. Development integration via real and technological convergence. Experience of Poland and conclusions for Ukraine

    Michał G. Woźniak

    2014-09-01

    Full Text Available The paper summarizes main achievements, losses and gains during the first decade of Poland's membership in the EU, while also aiming at development of suggestions for the Polish economic policy in the years to come, as well as draws conclusions for Ukraine, which has now elected the strategy of international economic cooperation. The first part of the paper presents an empirical analysis of Poland's both real and technological convergence with the developed EU countries. These data show that since 1994, as the process of Poland integration with the EU commenced, our country significantly reduced the income and technology gap as compared to the EU. During the financial crisis, Poland 'felt' better than most European countries. In the second part of the paper we attempt to answer the question as to the current conditions of Polish economy development. It is demonstrated that Poland's economic success was due to multiple factors such as endogenous and exogenous, historical and those derived from present events. However, it can be assumed that integration with the EU has been an important positive factor in development of Poland during recent 20 years. Great importance was also vested in the implementation of economic reforms in Poland as well as in policy of the government, although not faultless. The last section of the paper identifies problems now faced by the EU and individual member states, including Poland as regards future years till 2020

  8. Conclusion: The Politics of Numbers – Censuses in the Post-Yugoslav States

    Soeren Keil

    2015-12-01

    Full Text Available This conclusion poses a number of questions related to policy issues and the censuses in the post-Yugoslav states. It is argued that censuses are always more than just a technical counting exercise. Census discussions in Western Europe tend to focus on regional funding, infrastructure support and long-term policy planning, and can be as contested and heated as questions over identity, religion and mother tongue in the post-Yugoslav states. However, identity-related questions in an area in which identity is still in flux and in which fundamental demographic changes have taken place recently, prevent any focus on more policy-oriented discussions. In their EU integration process, all of the post-Yugoslav countries will have to concentrate on issues such as economic development, sustainable infrastructure planning, budgeting within the strict rules of the most recent EU agreements and hence policy discussions should be at the forefront of the debates about the results of the censuses. Instead, discussions over who is counted and how remain of key importance in all countries (even those that have joined the EU, and demonstrate unconsolidated nation-building projects.

  9. Study of Antibiotic Resistance Pattern and Mutation in Genes gyrA and parC of Escherichia Coli Causing Urinary Tract Infection

    J. Faghri

    2016-07-01

    Full Text Available Introduction & Objective: Fluoroquinolones are essential antimicrobial agents used to treat UTIs. Clinical experiences have shown a high rate of antibiotic resistance among uropatho-gens. These resistance are usually the consequence of mutations involving genes encoding gyrA and parC. The aim of this study was to determine antimicrobial resistance pattern and the presence of mutations in regions that code for quinolone resistance in the genes gyrA and parC in clinical isolates of E. coli from a hospital in Isfahan, Iran. Materials & Methods: A total of 135 isolates of E.coli (from urine were collected from Sep-tember to February 2013 from Alzahra Hospital (Isfahan, Iran. Bacterial susceptibility to an-timicrobial agents was determined using disk diffusion method. PCR was performed to detect genes gyrA and parC. Then, 13 isolates were randomly chosen for genetic characterization of the quinolone-determining region (QRDR of the parC and gyrA genes. Results: Among 135 E. coli isolates, 61 isolates ( 45 % were resistant to fluoroquinolones. From 13 isolates, 11 isolates showed two mutations (Ser83Leu/ Asp87Asn and 2 isolates showed a single mutation (Ser83Leu in gyrA gene. Also, five different mutations were de-tected in parC gene in the E. coli isolates, encoding Ser80Ile, Ser80Val, Ser80Arg, Glu84Val, Gly78Ser. Conclusion: More research on the molecular basis of FQ resistance is required to develop new therapeutic strategies for FQ-resistant E. coli. To overcome antibiotic resistance antibiotic therapy should be limited and based on the susceptibility patterns of microorganisms. (Sci J Hamadan Univ Med Sci 2016; 23 (2:118-125

  10. The polarity protein Par6 is coupled to the microtubule network during molluscan early embryogenesis

    Homma, Taihei [Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Shimizu, Miho [Kuroda Chiromorphology Team, ERATO-SORST, JST, Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Kuroda, Reiko, E-mail: ckuroda@mail.ecc.u-tokyo.ac.jp [Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Kuroda Chiromorphology Team, ERATO-SORST, JST, Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902 (Japan)

    2011-01-07

    Research highlights: {yields} The cDNAs encoding Par6 and aPKC homologues were cloned from the snail Lymnaea stagnalis. {yields} L. stagnalis Par6 directly interacts with tubulin and microtubules and localizes to the microtubule cytoskeleton during the early embryogenesis. {yields} Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of body handedness. -- Abstract: Cell polarity, which directs the orientation of asymmetric cell division and segregation of fate determinants, is a fundamental feature of development and differentiation. Regulators of polarity have been extensively studied, and the critical importance of the Par (partitioning-defective) complex as the polarity machinery is now recognized in a wide range of eukaryotic systems. The Par polarity module is evolutionarily conserved, but its mechanism and cooperating factors vary among different systems. Here we describe the cloning and characterization of a pond snail Lymnaea stagnalis homologue of partitioning-defective 6 (Lspar6). The protein product LsPar6 shows high affinity for microtubules and localizes to the mitotic apparatus during embryonic cell division. In vitro assays revealed direct binding of LsPar6 to tubulin and microtubules, which is the first evidence of the direct interaction between the two proteins. The interaction is mediated by two distinct regions of LsPar6 both located in the N-terminal half. Atypical PKC, a functional partner of Par6, was also found to localize to the mitotic spindle. These results suggest that the L. stagnalis Par complex employs the microtubule network in cell polarity processes during the early embryogenesis. Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of handedness.

  11. Uterine adenomyosis in infertile patients: MR imaging findings and clinical conclusions

    Purpose: To evaluate the clinical value of magnetic resonance imaging (MRI) of the uterus and the pelvis in infertile female with symptomatic endometriosis for the assessment of uterine morphology and function. Materials and Methods: Forty-one infertile women (mean age: 33.2 years) with symptomatic endometriosis documented by laparoscopy were evaluated with highfield MRI (Sonata, Siemens) using T2- and T1-weighted sequences. In addition, the patients underwent hysterosalpingoscintigraphy (HSSG) for evaluation of the uterotubal transport capacity. Pathologic findings of the uterine junction zone were correlated with the laparoscopic results, clinical symptoms and uterotubal transport capacity. Results: Adenomyosis was diagnosed on T2-weighted MR-images in 35 (85.4%) patients (focal adenomatosis in 26 patients and diffuse adenomatosis in 9). Patients showing signs of adenomyosis tended to be older than patients without adenomyosis (mean age 34.1 years vs. 30.1 years) and showed a longer history of symptomatic endometriosis. A positive transport capacity in HSSG was observed in 73.1% (19/26) of the patients with focal adenomyosis and only 22.2% (2/9) of patients with diffuse adenomyosis. In 83.3% (5/6) of the patients without signs of adenomyosis, a positive uterotubal transport was documented. Conclusion: MRI of the uterus is a helpful diagnostic tool for the diagnosis of adenomyosis and for planning further therapies. Patients with the diagnosis of adenomyosis showed a reduced uterotubal transport capacity that depended on the severity of adenomyotic changes and might be a possible cause of infertility. (orig.)

  12. Managing nuclear waste: a better idea (Excerpt of conclusions and recommendations)

    The panel concludes that an immediate effort must be made to improve the credibility, internal flexibility and cost-effectiveness of the Office of Civilian Radioactive Waste Management (OCRWM). However, in recognition that no modification to DOE/OCRWM organization would necessarily provide adequate stability and continuity, it is our principal recommendation that investigation of the specific steps necessary to implement, for example, a dedicated federally chartered corporation (the first choice of the Panel voting on organizational tests), should be undertaken immediately so that Congress can have a precise understanding of the legislative changes required to bring about such an organization. The main thrust of the Panel study has dealt with the structure and capabilities of various organizational alternatives for managing the high-level radioactive waste management program. The Panel also gave consideration to the financing processes of the Nuclear Waste Policy Act (NWPA), and to certain financing alternatives which might be substituted for the existing mechanisms. In doing so, the Panel encountered an array of financial uncertainties which confront the radioactive waste management program as it moves forward over the next two decades. At this juncture, it is extremely difficult to predict how future events, programmatic developments, and economic influences will affect the financing structure and cost level over the term of the program. It is the Panel's conclusion that the financing mechanism provided by Congress under the Nuclear Waste Policy Act appears to be fair, amenable to administrative implementation and cost controls, and sufficiently flexible to accommodate the full-recovery requirement of the legislation. Under NWPA, utilities are assessed a fee of 1 mill per kilowatthour of nuclear-generated electricity, plus a one-time fee for spent fuel accumulated prior to April 7, 1983

  13. Psychosis, Delusions and the "Jumping to Conclusions" Reasoning Bias: A Systematic Review and Meta-analysis.

    Dudley, Robert; Taylor, Peter; Wickham, Sophie; Hutton, Paul

    2016-05-01

    We did a systematic review and meta-analysis to investigate the magnitude and specificity of the "jumping to conclusions" (JTC) bias in psychosis and delusions. We examined the extent to which people with psychosis, and people with delusions specifically, required less information before making decisions. We examined (1) the average amount of information required to make a decision and (2) numbers who demonstrated an extreme JTC bias, as assessed by the "beads task." We compared people with psychosis to people with and without nonpsychotic mental health problems, and people with psychosis with and without delusions. We examined whether reduced data-gathering was associated with increased delusion severity. We identified 55 relevant studies, and acquired previously unpublished data from 16 authors. People with psychosis required significantly less information to make decisions than healthy individuals (k= 33,N= 1935,g= -0.53, 95% CI -0.69, -0.36) and those with nonpsychotic mental health problems (k= 13,N= 667,g= -0.58, 95% CI -0.80, -0.35). The odds of extreme responding in psychosis were between 4 and 6 times higher than the odds of extreme responding by healthy participants and participants with nonpsychotic mental health problems. The JTC bias was linked to a greater probability of delusion occurrence in psychosis (k= 14,N= 770, OR 1.52, 95% CI 1.12, 2.05). There was a trend-level inverse association between data-gathering and delusion severity (k= 18;N= 794;r= -.09, 95% CI -0.21, 0.03). Hence, nonaffective psychosis is characterized by a hasty decision-making style, which is linked to an increased probability of delusions. PMID:26519952

  14. Food, plant food, and vegetarian diets in the US dietary guidelines: conclusions of an expert panel.

    Jacobs, David R; Haddad, Ella H; Lanou, Amy Joy; Messina, Mark J

    2009-05-01

    We summarize conclusions drawn from a panel discussion at the "Fifth International Congress on Vegetarian Nutrition" about the roles of and emphasis on food, plant food, and vegetarianism in current and future US dietary guidelines. The most general recommendation of the panel was that future dietary guidelines, following the lead of the 2005 Dietary Guidelines Advisory Committee, should emphasize food-based recommendations and thinking to the full extent that evidence allows. Although nutrient-based thinking and Dietary Reference Intakes (DRIs) may help ensure an adequate diet in the sense that deficiency states are avoided, the emphasis on DRIs may not capture many important nutritional issues and may inhibit a focus on foods. More generally, in the context of the conference on vegetarian nutrition, this report focuses on the history and structure of the Dietary Guidelines Advisory Committee, on various plant food-oriented recommendations that are supported by literature evidence, and on mechanisms for participating in the process of forming dietary guidelines. Among recommendations that likely would improve health and the environment, some are oriented toward increased plant food consumption and some toward vegetarianism. The literature on health effects of individual foods and whole lifestyle diets is insufficient and justifies a call for future food-oriented research, including expanding the evidence base for plant-based and vegetarian diets. The Dietary Guidelines Advisory Committee's role should be carried forward to creation of a publicly accessible icon (eg, the current pyramid) and related materials to ensure that the science base is fully translated for the public. PMID:19297463

  15. The chooz a expert survey program and its main conclusions for plant life management

    Because of the importance of PWR components life management represents for Electricity Companies, significant R and D programs are dedicated to identifying and analysing mechanisms and damage rates of the different degradation modes of these components, systems and structures. To assess R and D assumptions and to validate non destructive test results through reviews, expert survey programs on in-situ equipment may enhance the knowledge about most of the various phenomena involved. In this regard, an extensive program was launched after the Chooz A NPP was decommissioned in 1991, after 24 years in operation. This program gathered EDF, IPSN, FRAMATOME, ELECTRABEL and TRACTEBEL into partnership. The expert survey program was performed in various laboratories between 1995 and 1999 and includes: - on-site non destructive testing before sampling, - and metallurgical and mechanical tests performed on samples taken from the nuclear and non nuclear part of the unit. The expert survey program performed by Utilities in various laboratories involved the following equipment: - reactor vessel and internal equipment, - reactor coolant system (dissimilar metal welds, SS welds, cast austenitic ferritic steels), - feedwater plant piping (erosion-corrosion), - electric cables susceptible of temperature and irradiation induced ageing, - anchoring in civil engineering structures, - main primary circuit concerning activation measurement. In conclusion, the extensive Chooz A expert survey program yields numerous significant results. The main outcomes will contribute to validate non destructive tests and enhance our knowledge of some degradation mechanisms of often quite similar components present in units in operation. It is worthy to note that this program is of prime importance for operation feedback; the cost of the whole study amounts to approximately 10 Million Euros. (author)

  16. New peptide receptor radionuclide therapy of invasive cancer cells: in vivo studies using 177Lu-DOTA-AE105 targeting uPAR in human colorectal cancer xenografts

    The proposition of uPAR as a potential target in cancer therapy is advanced by its predominant expression at the invasive front of colorectal cancer (CRC) and its value as prognostic biomarker for poor survival in this disease. In this study, we provide the first in vivo proof-of-concept for a theranostic approach as treatment modality in a human xenograft colorectal cancer model. Methods: A DOTA-conjugated 9-mer high affinity uPAR binding peptide (DOTA-AE105) was radiolabeled with 64Cu and 177Lu, for PET imaging and targeted radionuclide therapy study, respectively. Human uPAR-positive CRC HT-29 cells were inoculated in Nude mice and treated with 177Lu-DOTA-AE105 once a visible tumor had formed. To evaluate the true effect of the targeted radiotherapy, two controls groups were included in this study, one receiving a 177Lu-labeled non-binding control peptide and one receiving vehicle. All animals were treated day 0 and 7. A parallel 18F-FLT PET/CT study was performed on day 0, 1, 3 and 6. Dosimetry calculations were based on a biodistribution study, where organs and tissue of interest were collected 0.5, 1.0, 2.0, 4.0 and 24 h post injection of 177Lu-DOTA-AE105. Toxicity was assessed by recording mouse weight and by H and E staining of kidneys in each treatment group. Results: uPAR-positive HT-29 xenograft was clearly visualized by PET/CT imaging using 64Cu-DOTA-AE105. Subsequently, these xenograft transplants were locally irradiated using 177Lu-DOTA-AE105, where a significant effect on tumor size and the number of uPAR-positive cells in the tumor was found (p 18F-FLT PET/CT imaging study revealed a significant correlation between 18F-FLT tumor uptake and efficacy of the radionuclide therapy. A histological examination of the kidneys from one animal in each treatment group did not reveal any gross abnormalities and the general performance of all treated animals also showed no indications of radioactivity-induced toxicity. Conclusion: These findings document for the

  17. Echovirus 30 associated with cases of aseptic meningitis in state of Pará, Northern Brazil

    Ceyla Maria Oeiras de Castro

    2009-05-01

    Full Text Available Investigation of the aetiology of viral meningitis in Brazil is most often restricted to cases that occur in the Southern and Southeastern Regions; therefore, the purpose of this study is to describe the viral meningitis cases that occurred in state of Pará, Northern Brazil, from January 2005-December 2006. The detection of enterovirus (EV in cerebrospinal fluid was performed using cell culture techniques, RT-PCR, nested PCR and nucleotide sequencing. The ages of the 91 patients ranged from 60 years old (median age 15.90 years. Fever (87.1%, headache (77.0%, vomiting (61.5% and stiffness (61.5% were the most frequent symptoms. Of 91 samples analyzed, 18 (19.8% were positive for EV. Twelve were detected only by RT- PCR followed by nested PCR, whereas six were found by both cell culture and RT-PCR. From the last group, five were sequenced and classified as echovirus 30 (Echo 30. Phylogenetic analyses revealed that Echo 30 detected in Northern Brazil clustered within a unique group with a bootstrap value of 100% and could constitute a new subgroup (4c according to the phylogenetic tree described by Oberste et al. (1999. This study described the first molecular characterization of Echo 30 in Brazil and this will certainly contribute to future molecular analyses involving strains detected in other regions of Brazil.

  18. Isotopic exchange between molecular hydrogen and liquid ammonia catalysed by alkali amides; Echange isotopique entre l'hydrogene moleculaire et l'ammoniac liquide catalyse par les amidures alcalins

    Delmas, R. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-06-15

    The catalytic action of alkali amides on the isotopic exchange between hydrogen and liquid ammonia has been reinvestigated. It was clear before this work that the reaction is homogeneous and first order with respect to the concentration of dissolved hydrogen, but the nature of the catalytic species was still subject to discussion. On one hand new precise kinetic measurements have been made with sodium, potassium, rubidium and cesium amide. On the other hand, the dissociation of these salts has been calculated with the help of the FUOSS-ONSAGER equation. If the rate of exchange is plotted as a function of the concentration of the free amide ion, a linear relationship is obtained. In our experimental conditions, primary salt effects are negligible and the concentration has to be used in the rate equations. This shows that only the free amide ion is acting as a catalytic species. Experiments on common ion effects and secondary salt effects support this conclusion. The results are in agreement with an associative mechanism. (author) [French] Une nouvelle etude de l'echange isotopique entre l'hydrogene et l'ammoniac liquide catalyse par les amidures alcalins a ete effectuee. II etait bien etabli avant le present travail que la reaction etait homogene et que sa vitesse etait du premier ordre par rapport a la concentration d'hydrogene dissous, mais la nature de l'espece catalytique etait encore controversee. De nouvelles mesures cinetiques precises ont ete faites avec les amidures de sodium, de potassium, de rubidium et de cesium. D'autre part, la dissociation de ces sels a ete calculee a l'aide de l'equation de FUOSS-ONSAGER. On constate que la vitesse d'echange est proportionnelle a la concentration de l'ion amidure libre. Dans nos conditions experimentales, les effets de sel primaires sont negligeables, l'equation de vitesse doit s'exprimer simplement en fonction des concentrations. Ceci indique que l

  19. La libération par Tupperware ?

    Achin, Catherine; Naudier, Delphine

    2009-01-01

    Au cours des années 1970, le développement de la vente directe à domicile a donné lieu à la formation de cercles de sociabilité entre femmes dans le cadre des réunions Tupperware. Ces rencontres ont contribué à diffuser par capillarité nombre d’idées et pratiques féministes. Elles n’ont pas été sans incidence sur le déroulement de certaines trajectoires de femmes des classes moyennes et populaires. Le partage d’expériences de la soumission féminine, conjugale, et la confrontation aux modèles ...

  20. Etude d’un plasma produit par ablation laser.

    DJAOUANI, Nedjwa

    2014-01-01

    L’ablation laser est une technique d’enlèvement de matière de la surface d’un solide ou d’un liquide par l’irradiation laser, largement utilisée aujourd’hui. Elle s’est développée depuis l’époque de l’invention des lasers (1960). Très rapidement, le processus d’ablation laser est devenu le sujet d’intérêt de beaucoup de scientifiques. Même si la réalisation d’ablation laser est assez simple, ce phénomène est très complexe ce qui confirme le fait que 50 ans après sa découverte i...

  1. Simulation numérique du soudage par frottement malaxage

    Guerdoux, Simon

    2007-01-01

    Ce travail présente le développement d'un outil numérique. Une formulation arbitrairement lagrangienne-eulérienne (ALE) est implémentée dans le logiciel 3D éléments finis FORGE3® pour simuler les différentes étapes du procédé de soudage par frottement malaxage (FSW). Une méthode découplée est utilisée : a) les champs de vitesses, pressions et températures du matériau sont calculés, b) la vitesse de maillage est calculée à partir de l'évolution des frontières du domaine et d'un critère de raff...

  2. Selfrac: experiments and conclusions on fracturing and self-healing processes in clays

    ). This article will mainly focus on the in-situ experiments and observations at HADES but will also contain the main conclusions of the SELFRAC project. (authors)

  3. Advanced thermal-hydraulic and neutronic codes: current and future applications. Summary and conclusions

    An OECD Workshop on Advanced Thermal-Hydraulic and Neutronic Codes Applications was held from 10 to 13 April 2000, in Barcelona, Spain, sponsored by the Committee on the Safety of Nuclear Installations (CSNI) of the OECD Nuclear Energy Agency (NEA). It was organised in collaboration with the Spanish Nuclear Safety Council (CSN) and hosted by CSN and the Polytechnic University of Catalonia (UPC) in collaboration with the Spanish Electricity Association (UNESA). The objectives of the Workshop were to review the developments since the previous CSNI Workshop held in Annapolis [NEA/CSNI/ R(97)4; NUREG/CP-0159], to analyse the present status of maturity and remnant needs of thermal-hydraulic (TH) and neutronic system codes and methods, and finally to evaluate the role of these tools in the evolving regulatory environment. The Technical Sessions and Discussion Sessions covered the following topics: - Regulatory requirements for Best-Estimate (BE) code assessment; - Application of TH and neutronic codes for current safety issues; - Uncertainty analysis; - Needs for integral plant transient and accident analysis; - Simulators and fast running codes; - Advances in next generation TH and neutronic codes; - Future trends in physical modeling; - Long term plans for development of advanced codes. The focus of the Workshop was on system codes. An incursion was made, however, in the new field of applying Computational Fluid Dynamic (CFD) codes to nuclear safety analysis. As a general conclusion, the Barcelona Workshop can be considered representative of the progress towards the targets marked at Annapolis almost four years ago. The Annapolis Workshop had identified areas where further development and specific improvements were needed, among them: multi-field models, transport of interfacial area, 2D and 3D thermal-hydraulics, 3-D neutronics consistent with level of details of thermal-hydraulics. Recommendations issued at Annapolis included: developing small pilot/test codes for

  4. LEAping to conclusions: A computational reanalysis of late embryogenesis abundant proteins and their possible roles

    Wise Michael J

    2003-10-01

    Full Text Available Abstract Background The late embryogenesis abundant (LEA proteins cover a number of loosely related groups of proteins, originally found in plants but now being found in non-plant species. Their precise function is unknown, though considerable evidence suggests that LEA proteins are involved in desiccation resistance. Using a number of statistically-based bioinformatics tools the classification of a large set of LEA proteins, covering all Groups, is reexamined together with some previous findings. Searches based on peptide composition return proteins with similar composition to different LEA Groups; keyword clustering is then applied to reveal keywords and phrases suggestive of the Groups' properties. Results Previous research has suggested that glycine is characteristic of LEA proteins, but it is only highly over-represented in Groups 1 and 2, while alanine, thought characteristic of Group 2, is over-represented in Group 3, 4 and 6 but under-represented in Groups 1 and 2. However, for LEA Groups 1 2 and 3 it is shown that glutamine is very significantly over-represented, while cysteine, phenylalanine, isoleucine, leucine and tryptophan are significantly under-represented. There is also evidence that the Group 4 LEA proteins are more appropriately redistributed to Group 2 and Group 3. Similarly, Group 5 is better found among the Group 3 LEA proteins. Conclusions There is evidence that Group 2 and Group 3 LEA proteins, though distinct, might be related. This relationship is also evident in the overlapping sets of keywords for the two Groups, emphasising alpha-helical structure and, at a larger scale, filaments, all of which fits well with experimental evidence that proteins from both Groups are natively unstructured, but become structured under stress conditions. The keywords support localisation of LEA proteins both in the nucleus and associated with the cytoskeleton, and a mode of action similar to chaperones, perhaps the cold shock chaperones

  5. Solar PAR and UVR modify the community composition and photosynthetic activity of sea ice algae.

    Enberg, Sara; Piiparinen, Jonna; Majaneva, Markus; Vähätalo, Anssi V; Autio, Riitta; Rintala, Janne-Markus

    2015-10-01

    The effects of increased photosynthetically active radiation (PAR) and ultraviolet radiation (UVR) on species diversity, biomass and photosynthetic activity were studied in fast ice algal communities. The experimental set-up consisted of nine 1.44 m(2) squares with three treatments: untreated with natural snow cover (UNT), snow-free (PAR + UVR) and snow-free ice covered with a UV screen (PAR). The total algal biomass, dominated by diatoms and dinoflagellates, increased in all treatments during the experiment. However, the smaller biomass growth in the top 10-cm layer of the PAR + UVR treatment compared with the PAR treatment indicated the negative effect of UVR. Scrippsiella complex (mainly Scrippsiella hangoei, Biecheleria baltica and Gymnodinium corollarium) showed UV sensitivity in the top 5-cm layer, whereas Heterocapsa arctica ssp. frigida and green algae showed sensitivity to both PAR and UVR. The photosynthetic activity was highest in the top 5-cm layer of the PAR treatment, where the biomass of the pennate diatom Nitzschia frigida increased, indicating the UV sensitivity of this species. This study shows that UVR is one of the controlling factors of algal communities in Baltic Sea ice, and that increased availability of PAR together with UVR exclusion can cause changes in algal biomass, photosynthetic activity and community composition. PMID:26310455

  6. Participatory Action Research (PAR) cum Action Research (AR) in Teacher Professional Development: A Literature Review

    Morales, Marie Paz E.

    2016-01-01

    This paper reviews Participatory Action Research as an approach to teacher professional development. It maps the origins of Participatory Action Research (PAR) and discusses the benefits and challenges that have been identified by other researchers in utilizing PAR approaches in conducting research. It draws ideas of combining the features of…

  7. Image enhancement of digital periapical radiographs according to diagnostic tasks

    Choi, Jin Woo; Han, Won Jeong; Kim, Eun Kyung [Dept. of Oral and Maxillofacial Radiology, Dankook University College of Dentistry, Cheonan (Korea, Republic of)

    2014-03-15

    his study was performed to investigate the effect of image enhancement of periapical radiographs according to the diagnostic task. Eighty digital intraoral radiographs were obtained from patients and classified into four groups according to the diagnostic tasks of dental caries, periodontal diseases, periapical lesions, and endodontic files. All images were enhanced differently by using five processing techniques. Three radiologists blindly compared the subjective image quality of the original images and the processed images using a 5-point scale. There were significant differences between the image quality of the processed images and that of the original images (P<0.01) in all the diagnostic task groups. Processing techniques showed significantly different efficacy according to the diagnostic task (P<0.01). Image enhancement affects the image quality differently depending on the diagnostic task. And the use of optimal parameters is important for each diagnostic task.

  8. Image enhancement of digital periapical radiographs according to diagnostic tasks

    his study was performed to investigate the effect of image enhancement of periapical radiographs according to the diagnostic task. Eighty digital intraoral radiographs were obtained from patients and classified into four groups according to the diagnostic tasks of dental caries, periodontal diseases, periapical lesions, and endodontic files. All images were enhanced differently by using five processing techniques. Three radiologists blindly compared the subjective image quality of the original images and the processed images using a 5-point scale. There were significant differences between the image quality of the processed images and that of the original images (P<0.01) in all the diagnostic task groups. Processing techniques showed significantly different efficacy according to the diagnostic task (P<0.01). Image enhancement affects the image quality differently depending on the diagnostic task. And the use of optimal parameters is important for each diagnostic task.

  9. Best estimate methods in thermal hydraulic safety analysis - Seminar Summary and Conclusions

    BDBA and SA scenarios, the 'trends' of accident progressions need to be predicted as realistic as possible. Also there is a need for better coupling of thermal-hydraulic computer codes with neutronic, mechanical, containment and PRA analyses. In general, best-estimate codes are being used in a 'conservative mode'. BDBA evaluation is necessary in the German licensing process since 1 January 1994 to ensure that even extremely unlikely events involving core melt-down would not require radical actions to ensure protection against the damaging effects of ionising radiation outside the fence of the installation site. No limit of safety margins is specified, a licensing limit is sufficient. It has to be assured that a given plant will not exceed the licensing limits. The purpose of using a best estimate code and performing an uncertainty evaluation is to provide assurance that the licensing limits will not be exceeded with a probability of 95% or more. BDBA analysis should not be conservative when the analysis is needed for risk reduction. The existing uncertainty methods are useful. Guidelines on the choice of methods has been given in the frame of the Uncertainty Methods Study (UMS). There is no completely general theory available. The differences in the results of various uncertainty methods are due to differences in application, mainly due to the more or less conservative specification of ranges or distributions for the uncertain input parameters. In the Uncertainty Methods Study the uncertainties were specified to the conservative side by most participants. The situation would be similar for conservative bounding analyses using best estimate codes when for some dominant parameters conservative values have to be specified. Further remarks and conclusions are included in the summaries of the specific sessions

  10. Severe accident management (SAM), operator training and instrumentation capabilities - Summary and conclusions

    The Workshop on Operator Training for Severe Accident Management (SAM) and Instrumentation Capabilities During Severe Accidents was organised in collaboration with Electricite de France (Service Etudes et Projets Thermiques et Nucleaires). There were 34 participants, representing thirteen OECD Member countries, the Russian Federation and the OECD/NEA. Almost half the participants represented utilities. The second largest group was regulatory authorities and their technical support organisations. Basically, the Workshop was a follow-up to the 1997 Second Specialist Meeting on Operator Aids for Severe Accident Management (SAMOA-2) [Reports NEA/CSNI/R(97)10 and 27] and to the 1992 Specialist Meeting on Instrumentation to Manage Severe Accidents [Reports NEA/CSNI/R(92)11 and (93)3]. It was aimed at sharing and comparing progress made and experience gained from these two meetings, emphasizing practical lessons learnt during training or incidents as well as feedback from instrumentation capability assessment. The objectives of the Workshop were therefore: - to exchange information on recent and current activities in the area of operator training for SAM, and lessons learnt during the management of real incidents ('operator' is defined hear as all personnel involved in SAM); - to compare capabilities and use of instrumentation available during severe accidents; - to monitor progress made; - to identify and discuss differences between approaches relevant to reactor safety; - and to make recommendations to the Working Group on the Analysis and Management of Accidents and the CSNI (GAMA). The Workshop was organised into five sessions: - 1: Introduction; - 2: Tools and Methods; - 3: Training Programmes and Experience; - 4: SAM Organisation Efficiency; - 5: Instrumentation Capabilities. It was concluded by a Panel and General Discussion. This report presents the summary and conclusions: the meeting confirmed that only limited information is needed for making required decisions

  11. The conclusions on the Th internal contamination by ingestion using animals

    The paper presents the results obtained in a study on the Th internal contamination by ingestion. We investigated the Th biodistribution, retention and elimination using the fission track method as high sensitivity analysis method and Wistar-London breed rats as experiment animals. Three Wistar-London breed rats (RAT 1, RAT 2 and RAT 3) were contaminated with a Th amount corresponding to an Annual Limit Intake using a Th solution. The animals, up to their sacrifice, were kept in normal life conditions and under permanent observation. The rats were sacrificed at different time intervals after their contamination: t(RAT 1) = 2 days, t(RAT 2) = 7 days and t(RAT 3) = 14 days, respectively. Immediately, after sacrifice, the vital organs of the rats were sampled. These samples were weighed, calcined and re-weighed. The evacuations, for each of the three rats, were sampled every 24 hours: urine on the filter paper and all excrements balls. These samples were weighed before and after calcination. The organs and the elimination samples were analysed by track detection using the fission track micromappings technique. This method can visualize the distribution of the investigate fissionable element (U, Th, etc.) in the vital organs of the contaminated rats. This advantage of the fission track method, used in our experiment, led us to draw the following conclusions: - the Th was retained in all vital organs of the contaminated rats, particularly in liver, lung, stomach and small intestine; - all investigated organ samples presented a non-uniform Th distribution, but only the RAT 1 organs presented a lot of inclusions ranging from 1 ppm up to 24 ppm Th concentration. For the others two rats, the Th distributions were also non-uniform, but without inclusions. The absence of inclusions for the RAT 2 and RAT 3 which were sacrificed at 7 days and 14 days, respectively, after contamination shows that the rat organisms tend to build up the Th in inclusions because Th is considered as

  12. Fauna of Noctuidae (Lepidoptera: Noctuoidea) in a pasture area in Altamira, Eastern Amazon, Pará, Brazil.

    Almeida, L P; Specht, A; Teston, J A

    2014-11-01

    This study evaluated the nocturnal fauna of Noctuidae in a pasture area in Altamira, Pará. Samples were collected monthly for two nights at the new moon period, from August 2007 to July 2008. We collected a total of 345 specimens (N) of 66 species (S). The most abundant species were Ptichodes basilans (Guenée) (n = 87), Leucania jaliscana (Schaus), Spodoptera frugiperda (JE Smith) (n = 28) and Argidia palmipes Guenée (n = 21). For the entire period, the following indexes were found: Shannon diversity H'= 3.20 and Brillouin H = 2.94, evenness of Shannon E'= 0.76 and Brillouin E= 0.76, and Berger-Parker dominance BP= 0.252. The greatest diversity was found in the dry season. According to the estimates of species richness, it is possible that between 14 to 72 more species exist in the region. PMID:25627612

  13. Conception d'un système de veille : une approche par le concept d'environnement pertinent

    Marcon, Christian

    2001-01-01

    L'efficacité de tout système de veille stratégique est directement corrélée au degré d'appropriation des informations qu'il fournit par les principaux décideurs de l'organisation. La qualité de l'interaction entre le système de renseignement et le système décisionnel est donc déterminante. Cette interaction dépend fortement de l'attention que les décideurs accordent aux informations qu'ils reçoivent, donc de la concordance entre ces informations et leurs centres d'intérêt. La démarche présent...

  14. Compression Myelopathy due to Proliferative Changes around C2 Pars Defects without Instability

    Kimura, Tetsuya; Tezuka, Fumitake; Abe, Mitsunobu; Yamashita, Kazuta; Takata, Yoichiro; Higashino, Kosaku; Sairyo, Koichi

    2016-01-01

    We report a case with compression myelopathy due to proliferative changes around the C2 pars defects without instability. A 69-year-old man presented with progressive clumsy hands and spastic gait. Plain radiographs showed bilateral spondylolysis (pars defects) at C2 and fusion between C2 and C3 spinous processes. Dynamic views revealed mobility through the pars defects, but there was no apparent instability. Computed tomography showed proliferative changes at the pars defects, which protruded into spinal canal. On magnetic resonance imaging, the spinal cord was compressed and intramedullary high signal change was found. A diagnosis of compression myelopathy due to proliferative changes around the C2 pars defects was made. We performed posterior decompression. Postoperatively, symptoms have been alleviated and images revealed sufficient decompression and no apparent instability. In patients with the cervical spondylolysis, myelopathy caused by instability or slippage have been periodically reported. The present case involving C2 spondylolysis is extremely rare. PMID:27340539

  15. Estimating photosynthetically active radiation (PAR) at the Earth's surface from satellite observations

    Current satellite algorithms to estimate photosynthetically active radiation (PAR) at the Earth's surface are reviewed, and selected results are presented. PAR can be obtained directly from top-of-atmosphere solar radiance, which is used to determine the transmissivity of the atmosphere. Since clouds do not absorb significantly at PAR wavelengths, the radiative transfer modeling is generally simplified compared to that for total insolation. The accuracies reported, about 10% and 6% on daily and monthly time scales, respectively, are useful for modeling oceanic and terrestrial primary productivity. The large short-term variability in the ratio of PAR and insolation, essentially due to clouds, is reduced at those time scales, suggesting that reasonably accurate PAR climatologies may be obtained from available insolation climatologies (satellite or other). (author)

  16. Compression Myelopathy due to Proliferative Changes around C2 Pars Defects without Instability.

    Kimura, Tetsuya; Sakai, Toshinori; Tezuka, Fumitake; Abe, Mitsunobu; Yamashita, Kazuta; Takata, Yoichiro; Higashino, Kosaku; Sairyo, Koichi

    2016-06-01

    We report a case with compression myelopathy due to proliferative changes around the C2 pars defects without instability. A 69-year-old man presented with progressive clumsy hands and spastic gait. Plain radiographs showed bilateral spondylolysis (pars defects) at C2 and fusion between C2 and C3 spinous processes. Dynamic views revealed mobility through the pars defects, but there was no apparent instability. Computed tomography showed proliferative changes at the pars defects, which protruded into spinal canal. On magnetic resonance imaging, the spinal cord was compressed and intramedullary high signal change was found. A diagnosis of compression myelopathy due to proliferative changes around the C2 pars defects was made. We performed posterior decompression. Postoperatively, symptoms have been alleviated and images revealed sufficient decompression and no apparent instability. In patients with the cervical spondylolysis, myelopathy caused by instability or slippage have been periodically reported. The present case involving C2 spondylolysis is extremely rare. PMID:27340539

  17. Anestesia e paralisia cerebral Anestesia y parálisis cerebral Anesthesia and cerebral palsy

    Március Vinícius M Maranhão

    2005-12-01

    riesgo, fisiopatología, cuadro clínico, diagnóstico, terapéuticas utilizadas bien como evaluación pre-operatoria, medicación pre-anestésica, manoseo intra y posoperatorio, analgesia posoperatoria y dolor crónico. CONCLUSIONES: El anestesista desempeña un papel importante en la disminución de la morbidez y mortalidad anestésico-quirúrgica en pacientes portadores de parálisis cerebral. El conocimiento de la fisiopatología de los diferentes tipos de parálisis cerebral bien como de las enfermedades asociadas y sus terapéuticas es imprescindible, pues permite al anestesista anticipar y precaver complicaciones intra y posoperatorias en este tipo de paciente.BACKGROUND AND OBJECTIVES: Cerebral palsy (CP is a non-progressive disease induced by CNS injury, which leads to patients' motor impairment. CP patients are often submitted to surgical procedures due to usual diseases and some surgical situations related with CP. The aim of this article was to review cerebral palsy aspects of interest to anesthesiologists to allow an adequate pre, intra and postoperative management of these patients. CONTENTS: This article addresses cerebral palsy aspects such as etiology, classification, risk factors, pathophysiology, clinical presentation, diagnosis and therapies and, in addition to preoperative evaluation, preanesthetic medication, intra and postoperative management, postoperative analgesia and chronic pain. CONCLUSIONS: Anesthesiologists play an important role in decreasing anesthetic-surgical morbidity and mortality of cerebral palsy patients. The understanding of different aspects of cerebral palsy pathophysiologies, in addition to those of associated diseases and their therapies is paramount, because it allows anesthesiologists to anticipate and prevent intra and postoperative complications in this type of patient.

  18. Preoperative concentrations of suPAR and MBL proteins are associated with the development of pneumonia after elective surgery for colorectal cancer

    Svendsen, Mads N.; Ytting, Henriette; Brünner, Nils; Nielsen, Hans J.; Christensen, Ib J.

    2006-01-01

    both, intra-abdominal abscess, anastomotic leakage, pneumonia, and blood stream infection. Data on perioperative blood transfusions in addition to clinical baseline characteristics were included as well. RESULTS: The numbers of surgical site infections, intra-abdominal abscesses, anastomotic leakages...... transfusion (p = 0.006; OR 1.5; 95% CI 1.1, 2.0) were associated with the development of pneumonia. Significant associations with other bacterial infections could not be demonstrated. Multivariate analysis including disease stage, sex, and age showed that suPAR, MBL, and perioperative blood transfusion were...... significantly and independently associated with postoperative pneumonia. CONCLUSION: Concentrations of suPAR and MBL, in addition to perioperative blood transfusion, were significantly associated with the development of postoperative pneumonia. No other statistically significant relationships could be...

  19. Study of the effect of the energy spectrum and of the total flux on the damage produced by neutrons in solids; Contribution a l'etude de l'influence du spectre et du flux integre sur les dommages crees par les neutrons dans les solides

    Dulieu, P.C. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1967-01-01

    In the first part are studied the general relationships between the physical effects produced by neutrons in solids, and the total flux and neutron energy spectrum; some examples are given. The second part, describes the application to a silicon damage detector whose principle is to use the damage produced in a PIN Junction for measuring the neutron flux (intermediate and fast) received by the detector. Chapter I is devoted to the experimental determination of the energy given to the atoms by a primary in the silicon. The results and conclusions drawn from this determination make it possible to consider, in chapter II, the calculation of the detectors response characteristics.Chapter III deals with the measurement of the detectors response function and it is noted that good agreement is obtained between the calculation and experimental results. The whole of the second part constitutes a test of the methods presented in the first part. (author) [French] Dans la premiere partie, nous etudions les relations generales qui lient les effets physiques engendres par les neutrons dans les solides au flux integre et au spectre des neutrons et nous donnons des exemples d'utilisation. La deuxieme partie est une application au detecteur de dommages en silicium, dont le principe est d'utiliser les dommages crees dans une jonction PIN pour mesurer les flux de neutrons (intermediaires et rapides) recus par le detecteur. Le chapitre I est consacre a la determination experimentale de l'energie cedee aux atomes par un primaire dans le silicium. Les resultats et les conclusions que l'on peut tirer de cette determination permettent d'aborder, au chapitre II, le calcul de la fonction de reponse du detecteur. Le chapitre III porte sur la mesure de la fonction de reponse du detecteur et on constate qu'il y a un bon accord entre le calcul et l'experience. L'ensemble de la deuxieme partie constitue un test des methodes exposees dans la premiere partie

  20. MODIS-derived daily PAR simulation from cloud-free images and its validation

    Chen, Liangfu; Gu, Xingfa; Tian, Guoliang [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); The Center for National Spaceborne Demonstration, Beijing 100101 (China); Gao, Yanhua [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101 (China); Yang, Lei [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Jilin University, Changchun 130026 (China); Liu, Qinhuo [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China)

    2008-06-15

    In this paper, a MODIS-derived daily PAR (photosynthetically active radiation) simulation model from cloud-free image over land surface has been developed based on Bird and Riordan's model. In this model, the total downwelling spectral surface irradiance is divided into two parts: one is beam irradiance, and another is diffuse irradiance. The attenuation of solar beam irradiance comprises scattering by the gas mixture, absorption by ozone, the gas mixture and water vapor, and scattering and absorption by aerosols. The diffuse irradiance is scattered out of the direct beam and towards the surface. The multiple ground-air interactions have been taken into account in the diffuse irradiance model. The parameters needed in this model are atmospheric water vapor content, aerosol optical thickness and spectral albedo ranging from 400 nm to 700 nm. They are all retrieved from MODIS data. Then, the instantaneous photosynthetically available radiation (IPAR) is integrated by using a weighted sum at each of the visible MODIS wavebands. Finally, a daily PAR is derived by integration of IPAR. In order to validate the MODIS-derived PAR model, we compared the field PAR measurements in 2003 and 2004 against the simulated PAR. The measurements were made at the Qianyanzhou ecological experimental station, Chinese Ecosystem Research Network. A total of 54 days of cloud-free MODIS L1B level images were used for the PAR simulation. Our results show that the simulated PAR is consistent with field measurements, where the correlation coefficient of linear regression between calculated PAR and measured PAR is 0.93396. However, there were some uncertainties in the comparison of 1 km pixel PAR with the tower flux stand measurement. (author)

  1. Facoemulsificação, vitrectomia via pars plana e implante de lente intra-ocular em olhos com retinopatia diabética proliferativa Phacoemulsification, pars plana vitrectomy and intraocular lens implant in eyes with proliferative diabetic retinopathy

    Armando Belfort Mattos

    2004-06-01

    realizar a vitrectomia via pars plana, ao invés de se realizar uma segunda cirurgia, que seria somente para a remoção da catarata após a vitrectomia pars plana, é técnica segura e capaz de promover a melhora da acuidade visual além de ser menos agressiva para o paciente. O potencial para melhora da acuidade visual final é limitado pela gravidade da retinopatia diabética.PURPOSE: To evaluate the outcomes and the best technique for a combined phacoemulsification (PHACO, pars plana vitrectomy (PPV and posterior chamber intraocular lens insertion (PCIOL in one single procedure for patients with proliferative diabetic retinopathy. METHODS: We reviewed charts of 47 (53 eyes patients with proliferative diabetic retinopathy who underwent combined phacoemulsification with posterior chamber intraocular lens implant and pars plana vitrectomy performed between January 1991 and September 1998 at the Bascom Palmer Eye Institute, eye hospital affiliated with the University of Miami. The study was done in conjunction with the Federal University of São Paulo. A total of 43 eyes from 40 patients were elected to participate in the study. RESULTS: The follow-up range was three to 60 months (mean 20 months. The age ranged from 37 to 77 years with a mean of 59. Preoperative visual acuity improved two lines or more in 26 (60.4% eyes, remained the same in 9 (20.9% and got worse in 8 (18.6%. In 10 (23.2% eyes visual acuity improved to 20/40. The study showed to be statistically significant for the improvement of the final visual acuity. Recurrent vitreous hemorrhage was the most frequent postoperative complication found in 12 (27.9% eyes and it was followed by transient anterior chamber reaction in 9 (20.9% eyes. Intraoperative and postoperative complications related to phacoemulsification were rare. IOL capture was found in 2 (4.6% eyes and intraocular lens subluxation in 1 (2.3% eye. CONCLUSION: Combined phacoemulsification with posterior chamber intraocular lens implant and pars plana

  2. How Mobile Devices Affect Students According to Teachers' Beliefs

    Cumaoglu, Gonca Kizilkaya

    2015-01-01

    The purpose of this study is to examine teachers' beliefs concerning the effects on students using mobile devices, and to determine whether these beliefs vary according to the demographic characteristics and Internet usage purposes. For this purpose, a demographic information questionnaire and the scale developed by Diker Coskun & Kizilkaya…

  3. Equipment for flow measurements according to the ultrasonic Doppler method

    An instrument for flow measurements according to the ultrasonic Doppler method is described. It consists of an applicator with an ultrasonic oscillator and, connected to it, a Doppler instrument for the Doppler flow record. The angle of incidence of the ultrasonic beam may be taken into account, flow measurement independent of the angle thus becoming possible. (RW)

  4. Examining Teachers' Motivation Level According to School Principals' Humor Styles

    Recepoglu, Ergun; Kilinc, Ali Cagatay; Cepni, Osman

    2011-01-01

    The purpose of this research is to examine the motivation level of teachers according to school principals' humor styles. The humor styles survey and job motivation scale were used to gather data from 305 randomly selected teachers employed in primary schools in Karabuk. Results indicated that 141 of the teachers claimed school principal had…

  5. Study of some continuous spectra produced by nuclear reactions with light nuclei; Etude de quelques spectres continus produits par reactions nucleaires avec des noyaux legers

    Marquez, L

    1966-07-01

    The continuous spectra coming from several nuclear reactions with light nuclei were measured. The spectra can be explained by a two-step reaction mechanism; however, the reactions produced by {sup 6}Li are different. A mechanism was proposed to explain their spectra based on the following assumptions: {sup 6}Li makes a nuclear molecule with the target which subsequently breaks up in such a way that an {alpha} particle comes out with the kinetic energy that it has in the molecule. The calculated spectra and those measured are in good agreement. (author) [French] Nous avons mesure les spectres continus produits dans plusieurs reactions nucleaires avec des noyaux legers. A l'exception des spectres produits par {sup 6}Li, on a trouve qu'on pouvait expliquer ces spectres par le mecanisme des reactions en deux etapes. Nous avons propose un mecanisme pour expliquer les spectres produits par {sup 6}Li. On suppose que {sup 6}Li forme une molecule nucleaire avec la cible qui eclate ensuite de facon telle qu'une particule alpha de la molecule sort avec l'energie cinetique de son mouvement propre dans la molecule. Les spectres calcules avec ces hypotheses et les spectres mesures sont en bon accord. (auteur)

  6. Conclusions : comme un reflet de la géographie des transports à la française

    Frédéric Dobruszkes

    2012-12-01

    Full Text Available La sélection de textes ici publiés nous semble être, à son échelle, un bon reflet de la géographie des transports telle qu’elle se conçoit aujourd’hui en France, avec ses caractéristiques propres, ses qualités, ses modes et ses manques. D’emblée, on est frappé de constater que, malgré tout son intérêt, la production scientifique de ce Belgeo est largement franco-française. Elle l’est d’abord par l’absence des collègues francophones de Suisse, du Canada et du Luxembourg, rarement présents au c...

  7. Combined 20-gauge and 23-gauge pars plana vitrectomy for the management of posteriorly dislocated lens: a case series

    Pipat Kongsap

    2010-06-01

    Full Text Available Pipat KongsapDepartment of Ophthalmology, Prapokklao Hospital, Chanthaburi, Thailand; Affiliated with the Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandObjective: To present a new surgical approach for the management of posteriorly dislocated lens by using a combination of 20-gauge (20G and 23-gauge (23G pars plana vitrectomy.Design: An interventional case seriesMethods: This technique was performed on six patients (five men, one woman; mean age, 66.67 years; range, 66–72 years. Two 23G trans-conjunctival sclerotomy ports were created for infusion and illumination along with a 20G sclerotomy port for introducing the vitrectomy probe or fragmatome.Results: This procedure was successfully performed on six eyes. On postoperative day one, the media were clear and the retina could be seen by indirect ophthalmoscopy. Hyphema developed in one eye and resolved within a week. There were no observed cases of retinal tear, wound leakage, hypotony, or endophthalmitis. The post-operative follow-up period ranged from three to twelve months (mean, 8.1 months. By the final visit, two patients had achieved a visual acuity of 20/40 or better, three patients, 20/70, and one patient, 20/200.Conclusion: The combination of 20G and 23G pars plana vitrectomy is an efficacious and safe procedure for management of posteriorly dislocated lens.Keywords: lensectomy, fragmatome, sutureless vitrectomy

  8. 2-Arachidonoyl glycerol sensitizes the pars distalis and enhances forskolin-stimulated prolactin secretion in Syrian hamsters.

    Yasuo, Shinobu; Fischer, Claudia; Bojunga, Joerg; Iigo, Masayuki; Korf, Horst-Werner

    2014-04-01

    2-Arachidonoyl glycerol (2-AG) is a major endocannabinoid and an important regulator of neuroendocrine system. In Syrian hamster and human, we found that 2-AG is synthesized in the hypophysial pars tuberalis (PT), an interface between photoperiodic melatonin signals and neuroendocrine output pathways. The target of 2-AG produced in the PT is likely to be the pars distalis (PD). Here we demonstrate that 2-AG in combination with forskolin stimulated prolactin secretion from PD organ cultures of Syrian hamsters, whereas incubation with 2-AG alone had no effect. Forskolin-induced prolactin secretion was also significantly enhanced when cultured PD tissue was preincubated with 2-AG. The stimulatory effects of 2-AG on prolactin secretion were blocked by AM251, a selective CB1 antagonist, and were still observed in the presence of quinpirole, a D2-class dopamine receptor agonist. 2-AG also enhanced prolactin secretion in the presence of adenosine, while it had little effect when applied together with adenosine diphosphate (ADP) and adenosine triphosphate (ATP). Moreover, the effect of forskolin was mimicked by adenosine in a dose-dependent manner. In conclusion, our data suggest that 2-AG sensitizes the PD tissue to potentiate the stimulating effects of forskolin and adenosine on prolactin secretion and thus provide novel insight into the mode of action of 2-AG in the PD. PMID:24200164

  9. Profiling gene expression induced by protease-activated receptor 2 (PAR2 activation in human kidney cells.

    Jacky Y Suen

    Full Text Available Protease-Activated Receptor-2 (PAR2 has been implicated through genetic knockout mice with cytokine regulation and arthritis development. Many studies have associated PAR2 with inflammatory conditions (arthritis, airways inflammation, IBD and key events in tumor progression (angiogenesis, metastasis, but they have relied heavily on the use of single agonists to identify physiological roles for PAR2. However such probes are now known not to be highly selective for PAR2, and thus precisely what PAR2 does and what mechanisms of downstream regulation are truly affected remain obscure. Effects of PAR2 activation on gene expression in Human Embryonic Kidney cells (HEK293, a commonly studied cell line in PAR2 research, were investigated here by comparing 19,000 human genes for intersecting up- or down-regulation by both trypsin (an endogenous protease that activates PAR2 and a PAR2 activating hexapeptide (2f-LIGRLO-NH(2. Among 2,500 human genes regulated similarly by both agonists, there were clear associations between PAR2 activation and cellular metabolism (1,000 genes, the cell cycle, the MAPK pathway, HDAC and sirtuin enzymes, inflammatory cytokines, and anti-complement function. PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2 and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15. Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4 known to be important in cancer. This is the first widespread profiling of specific activation of PAR2 and provides a valuable platform for better understanding key mechanistic roles of PAR2 in human physiology. Results clearly support the development of both antagonists and agonists of human PAR2 as potential disease modifying therapeutic agents.

  10. Usos do território e poder do atraso em Barcarena (Pará

    Santos Nahum João

    2011-07-01

    Full Text Available Abordamos aqui os usos do território e o poder do atraso em Barcarena, estado do Pará, a partir da década de 1980, momento de implantação do sistema de engenharia produtor de alumínio primário da Albrás/Alunorte. O objetivo deste artigo é expor como na dinâmica territorial barcarenense, modernização e atraso se reproduzem dialeticamente. O texto é composto de duas partes centrais, além da introdução e conclusão. Na primeira parte expomos dados acerca do crescimento das finanças públicas municipais a partir da implantação do grande projeto da Albrás/Alunorte. Na segunda parte, focalizamos na alocação de tais recursos pela gestão pública municipal ações políticas típicas do poder do atraso. Para tanto, analisamos as respostas do poder público às demandas da população, isto é, o clientelismo político e o planejamento tradicional norteador do Plano Plurianual 2002-2005 e 2006-2009.

  11. Treatment of dystrophic calcification on a silicone intraocular lens with pars plana vitrectomy

    Mehta N

    2014-07-01

    Full Text Available Nitish Mehta,1 Roger A Goldberg,2 Chirag P Shah21University of Massachusetts Medical School, Worcester, MA, USA; 2Department of Retina, Ophthalmic Consultants of Boston, Boston, Massachusetts, USAPurpose: Dense, vision-obscuring calcification on the posterior aspect of silicone intraocular lenses (IOLs is often not amenable to neodymium:yttrium-aluminum-garnet capsulotomy, and, in prior reports, has required IOL exchange. We report the successful removal of dense calcium deposition on the posterior surface of a three-piece silicone lens using pars plana vitrectomy (PPV.Materials and methods: A 23-gauge PPV was performed using the Stellaris® vitrectomy system. A light pipe was used to retroilluminate the IOL, and a dense fibrous tissue setting with a low cut-rate and high aspiration rate was able to clear the visual axis of the dystrophic calcification without damaging the IOL optic.Results: Visual acuity improved from 20/100 to 20/25.Conclusion: Small-gauge PPV may be utilized to remove dense dystrophic calcium deposits on the lens surface in lieu of IOL exchange. Keywords: cataract surgery, technique, Nd:YAG capsulotomy, IOL exchange

  12. Antimicrobial Resistance of Shigella spp. isolated in the State of Pará, Brazil

    Flávia Corrêa Bastos

    2011-10-01

    Full Text Available INTRODUCTION: Shigella spp. are Gram-negative, nonsporulating, rod-shaped bacteria that belong to the family Enterobacteriaceae and are responsible for shigellosis or bacillary dysentery, an important cause of worldwide morbidity and mortality. METHODS: We studied the antibiotic resistance profiles of 122 Shigella spp. strains (81 S. flexneri, 41 S. sonnei, 1 S. boydii isolated from patients (female and male from 0 to 80 years of age presenting diarrhea in different districts of the State of Pará, in the North of Brazil. The antibiotic resistance of the strains, isolated from human fecal samples, was determined by the diffusion disk method and by using the VITEK-2 system. RESULTS: The highest resistance rate found was the resistance rate to tetracycline (93.8%, followed by the resistance rate to chloramphenicol (63.9% and to trimethoprim/sulfamethoxazole (63.1%. Resistance to at least three drugs was more common among S. flexneri than S. sonnei (39.5% vs. 10%. Six (4.9% strains were susceptible to all the antibiotics tested. All strains were susceptible to cefotaxime, ceftazidime, ciprofloxacin, nalidixic acid and nitrofurantoin. CONCLUSIONS: High rates of multidrug resistance in Shigella spp. are a serious public health concern in Brazil. It is extremely important to continuously monitor the antimicrobial resistances of Shigella spp. for effective therapy and control measures against shigellosis.

  13. Evaluation of pars plana sclera fixation of posterior chamber intraocular lens

    Fangju Han

    2014-01-01

    Full Text Available Purpose: The purpose of this study was to evaluate the clinical efficacy and safety of modified posterior chamber intraocular lens (PCIOL implantation with transscleral fixation. Design and Setting: This is a study, which is conducted at Department of Ophthalmology, Jinan Eye Hospital, Jinan Second People′s Hospital. Materials and Methods: A total of 82 patients who were scheduled for sutured PCIOL were divided randomly into modified and conventional groups. The former underwent PCIOL through pars plana fixation with knot buried and without scleral flap and the latter underwent transscleral fixation of PCIOL in the ciliary sulcus. The main outcome measures included operative time, postoperative visual acuity, and postoperative complications. Results: The mean operative time of the modified group was 39.95 ± 5.87 min, which was significantly less than that of the conventional group (45.77 ± 5.21 min; P < 0.05. No difference was found in postoperative visual acuity between the two groups. There were no significant postoperative complications, including knot exposure, endophthalmitis, and retinal detachment in either group. The optical clamping of PCIOL was prone to occur in the conventional group. Conclusion: Modified sutured PCIOL implantation is a safe, effective, and feasible technique for the correction of aphakia in eyes without adequate posterior capsular support.

  14. Facteurs de risque de mortalité par tuberculose pulmonaire

    Janah, Hicham; Souhi, Hicham; Kouismi, Hatim; Mark, Karima; Zahraoui, Rachida; Benamor, Jouda; Soualhi, Mona; Bourkadi, Jamal Eddine

    2014-01-01

    La tuberculose est une maladie infectieuse transmissible provoquée par myco-bacterium tuberculosis (bacille de Koch ou BK). Elle représente, selon les estimations del'Organisation Mondiale de la Santé (OMS), l'une des pathologies infectieuses causant le plus de décès au niveau mondial avec plus de 1 million de décès par an. Pour déterminer les facteurs de risque de mortalité au cours de la tuberculose pulmonaire à microscopie positive nous avons mené une étude rétrospective portant sur tous les cas de tuberculose pulmonaire à microscopie positive et qui étaient décédés au cours de leur hospitalisation. Cette étude a colligé 1803 cas de tuberculose sur une période de 2 ans et demi dont 46 sont décédés. La prévalence de décès est de 2,55%. La population se répartit en 32 hommes et 14 femmes. L’âge moyen était de 53ans ± 17 ans. Le tabagisme était retrouvé chez la moitié des cas. Une comorbidité était retrouvée dans 43%, avec 17% de diabète. Le délai de diagnostic avait une médiane de 60 jours avec percentile (30j; 105j). La symptomatologie clinique était dominée par la toux, la dyspnée et les expectorations soit respectivement: 97,8%, 69,6% et 67,4% des cas. Sur le plan radiologique les lésions étaient diffuses et bilatérales dans 76,1% des cas. Tous les patients étaient mis sous SRHZ. 11% avaient présenté une toxicité aux antibacillaires (de type hépatiques dans 3 cas et neurologiques dans 2 cas). Le délai médian de décès était de 8,5 jours (5j; 17j). Les causes de décès retrouvées étaient: Une hépatite fulminante (3 cas), une décompensation acido-cétosique (3 cas), un SDRA (2 cas), des hémoptysies foudroyantes (2 cas), et respectivement un cas secondaire à une décompensation de BPCO, une décompensation cardiaque, une hypoglycémie et un tableau d'anasarque. Cette étude suggère que le terrain, le retard diagnostique et les effets secondaires du traitement sont les principaux facteurs de risque de

  15. The 14-3-3 protein PAR-5 regulates the asymmetric localization of the LET-99 spindle positioning protein.

    Wu, Jui-Ching; Espiritu, Eugenel B; Rose, Lesilee S

    2016-04-15

    PAR proteins play important roles in establishing cytoplasmic polarity as well as regulating spindle positioning during asymmetric division. However, the molecular mechanisms by which the PAR proteins generate asymmetry in different cell types are still being elucidated. Previous studies in Caenorhabditis elegans revealed that PAR-3 and PAR-1 regulate the asymmetric localization of LET-99, which in turn controls spindle positioning by affecting the distribution of the conserved force generating complex. In wild-type embryos, LET-99 is localized in a lateral cortical band pattern, via inhibition at the anterior by PAR-3 and at the posterior by PAR-1. In this report, we show that the 14-3-3 protein PAR-5 is also required for cortical LET-99 asymmetry. PAR-5 associated with LET-99 in pull-down assays, and two PAR-5 binding sites were identified in LET-99 using the yeast two-hybrid assay. Mutation of these sites abolished binding in yeast and altered LET-99 localization in vivo: LET-99 was present at the highest levels at the posterior pole of the embryo instead of a band in par-5 embryos. Together the results indicate that PAR-5 acts in a mechanism with PAR-1 to regulate LET-99 cortical localization. PMID:26921457

  16. La limitation de l’ontologie par la logique

    John J. Drummond

    2009-02-01

    Full Text Available Cet article maintient que l’intérêt de Husserl pour le développement d’une logique pure en tant que théorie de la science limite sa conception de l’ontologie. L’ontologie formelle est, pour Husserl, une théorie formelle des objets de connaissance, dont les catégories fondamentales sont celles de substance, propriété et relation. En outre, les ontologies régionales évoluent au sein des limites catégorielles définies par l’ontologie formelle. Mais une telle ontologie laisse de côté les activités et les processus de tout genre, parmi lesquels le plus important est celui de l’ « avoir à l’esprit ». La phénoménologie transcendantale, en revanche, s’occupe de l’être-conscient-du-monde, un être-conscient qui est cependant inséparable de l’être-dans-le-monde. Cette phénoménologie se situe sur le même terrain ontologique que l’ontologie fondamentale de Heidegger. Mais alors, bien que la notion husserlienne d’ontologie soit limitée par le rôle dominant attribué à la logique en tant que théorie de la science et à la connaissance vraie qui lui est propre, il y a plus d’ontologie chez Husserl que dans son « ontologie ».This paper argues that Husserl’s concern with the development of pure logic as a theory of science limits his conception of ontology. Formal ontology is, for Husserl, a formal theory of the objects of cognition, and its fundamental categories are substantiality, property, and relation. Moreover, regional ontologies work within the categorial boundaries defined by formal ontology. Lost from view in this ontology are activities and processes of various kinds, of which “minding” is the most significant. Husserl’s transcendental phenomenology is an account of being-conscious-of-the-world, a being-conscious, however, that is inseparable from being-in-a-world.  This phenomenology is aimed at the same ontological terrain as Heidegger’s fundamental ontology. Hence, while

  17. Représentation de l’espace et du temps dans le modèle situationnel construit par un lecteur

    Yves Bestgen

    2008-04-01

    Full Text Available Depuis plus de vingt ans, un des défis majeurs de la psycholinguistique est de décrire la nature de la représentation mentale construite par un lecteur. Si cette question est à l’étude depuis tant d’années, c’est que, contrairement à d’autres processus comme l’accès lexical ou l’analyse syntaxique, la compréhension d’un texte est restée pendant longtemps un objet difficilement étudiable scientifiquement en raison du manque de rigueur dans sa définition et de l’absence de modèles suffisamment explicites. Tel n’est plus le cas aujourd’hui. Les chercheurs s’accordent, en effet, pourdéfinir la compréhension d’un texte comme la construction d’une représentation situationnelle qui combine les propositions extraites du texte à celles qui ont été réactivées en mémoire à long terme afin de constituer une représentation non du texte, mais de ce dont le texte parle. Parmi les multiples dimensions censées être représentées dans le modèle situationnel, l’espace et le temps sont certainement ceux qui ont retenu le plus d’attention. L’objet du présent travail est de confronter nos connaissances à propos du rôle de ceux-ci lors de la construction du modèle situationnel. Une telle analyse semble particulièrement fructueuse parce que le temps et l’espace ont été étudiés selon deux points de vues différents et pourtant complémentaires. L’étude du temps s’est focalisée principalement sur les moyens linguistiques permettant d’exprimer celui-ci dans les textes (p. ex. les adverbiaux temporels et sur leur impact lors de la compréhension. Par contre, la manière dont les informations spatiales sont présentées dans un texte a retenu bien peu l’attention au profit de la question de savoir si et comment la multidimensionnalité de l’espace peut être reconstruite par le lecteur sur la base de la linéarité d’un texte. Un des objectifs spécifiques de ce travail est de proposer, sur

  18. Importância dos parâmetros seminais nos resultados de inseminação intra-uterina Importance of seminal parameters for intrauterine insemination outcomes

    Edson Borges Junior

    2003-05-01

    Full Text Available OBJETIVOS: analisar a relevância dos parâmetros seminais nos resultados dos ciclos de inseminação intra-uterina (IIU em pacientes com causa masculina de infertilidade e salientar o caráter prognóstico de cada parâmetro para o sucesso da técnica. MÉTODOS: duzentos e trinta e nove ciclos de IIU (155 casais foram analisados durante período de 15 meses. Todos as pacientes foram submetidas à indução da ovulação de acordo com protocolos do I Consenso Brasileiro de Indução de Ovulação. A análise seminal foi realizada de acordo com os critérios da Organização Mundial da Saúde (OMS para parâmetros como concentração e motilidade e critério estrito de Kruger para avaliação da morfologia. O preparo da amostra para IIU foi realizado por meio de gradientes descontínuos de densidade (ISolate®. Foram formados dois grupos de pacientes de acordo com o resultado de gestação: grupo G - gestação positiva e grupo NG - gestação negativa. RESULTADOS: não houve diferença significativa nos valores obtidos relacionados à concentração total de espermatozóides/mL de sêmen, motilidade total, motilidade de formas progressivas antes e depois do processamento seminal. Quando a morfologia estrita de Kruger foi comparada entre os dois grupos, diferenças significativas foram encontradas (grupo G=10,6% de formas normais; grupo NG=6,4% de formas normais; pPURPOSE: to analyze the influence of seminal parameters on intrauterine insemination (IUI outcomes in patients with male factor and to emphasize the predictive value of each parameter for the successful result. METHODS: two hundred and thirty-nine IUI cycles (155 couples were analyzed for 15 months. Female patients were submitted to ovary hyperstimulation according to the "I Consenso Brasileiro de Indução de Ovulação". Seminal analysis based on the World Health Organization (WHO for sperm concentration and motility was used and sperm morphology was evaluated according to Kruger

  19. Organisation du cadre participatif, accord et répétition dans l'interaction

    Traverso Véronique

    2012-07-01

    Full Text Available L'étude relève de l'analyse des interactions. Elle porte sur un certain usage des répétitions indiquant l'accord comme procédé permettant l'organisation de différentes "parties" au sein du cadre de participation global dans des situations (des réunions. Les questions traitées sont les suivantes : - comment les participants qui utilisent des hétéro-répétitions pour exprimer leur accord avec un autre participant parviennent-ils à rendre leur contribution distincte de celle du partenaire dont ils répètent l'énoncé ? - comment font-ils en sorte que leur propre voix ne se perde pas dans celle de la partie qu'ils contribuent à créer en répétant les propos d'un autre ? L'étude est basée sur un corpus de réunions de travail enregistrées en audio et en vidéo. L'analyse dégage trois contextes : le premier concerne un sens minimal de "partie", il est très local, c'est celui qui se met en place dans le cadre de l'échange question / réponse ; le second concerne des cas où deux parties sont opposées par un désaccord ; le troisième des cas où deux co-narrateurs s'adressent à un groupe. Elle permet de dégager des formes différentes des répétitions dans ces trois contextes. Les répétitions sont ensuite examinées en fonction de leur rôle vis-à-vis de celui qui est répété et vis-à-vis du reste du cadre de participation. Elles sont analysées en relation avec la façon dont elle permettent de négocier d'une part le droit à la parole et d'autre part l'autorité épistémique.

  20. Effects of solar PAR and UV radiation on tropical biofouling communities

    Dobretsov, SV

    2010-03-08

    We investigated the effect of solar ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) on the development of tropical micro- and macrofouling communities for 30 d. The experimental design involved 3 treatments: full spectrum (PAR+UVR), PAR only, and minimal light (reduced PAR and UVR). Terminal restriction fragment length polymorphism analysis demonstrated that different light conditions resulted in the formation of highly different microbial communities. The lowest densities of bacteria were found under the full spectrum treatment, while the lowest densities of diatoms were found in the minimal light treatment. Macrofouling communities consisted of 13 species and differed among light treatments. In the presence of UVR, communities had low species diversity, evenness, and richness, while in minimal light and PAR treatments, communities had high species diversity, evenness, and richness. Similarity percentage (SIMPER) analysis revealed that the tubeworm Hydroides elegans, the alga Ulva (Enteromorpha) sp., and the bivalve Perna viridis were the species responsible for most of the dissimilarities in macrofouling communities among treatments. While densities of H. elegans were similar in the PAR and minimal light treatments, this polychaete had higher growth rates under minimal light conditions. We conclude that UVR and PAR directly control the development of shallow micro- and macrofouling communities by inhibiting the recruitment and growth of sensitive species and promoting the growth of resistant species, but also that these forms of solar radiation influence the surface cues available to competent larvae by altering the development of the microbial community.

  1. Scientific Opinion supplementing the conclusions of the environmental risk assessment and risk management recommendations on the genetically modified insect resistant maize 1507 for cultivation

    EFSA Panel on Genetically Modified Organisms (GMO

    2012-11-01

    Full Text Available The EFSA GMO Panel was asked by the European Commission to apply its mathematical model to simulate and assess potential adverse effects resulting from the exposure of non-target Lepidoptera to maize 1507 pollen under hypothetical agricultural conditions, and to provide information on the factors affecting the insect resistance management plan, additional to that in its 2011 Scientific Opinion updating the conclusions of the environmental risk assessment and risk management recommendations on maize 1507. Here, risk managers are provided with additional evidence and further clarifications to those previous conclusions and risk management recommendations. This Scientific Opinion provides background scientific information to inform the decision-making processes; the EFSA GMO Panel reiterates that risk managers should choose risk mitigation and management measures that are proportionate to the level of identified risk according to the protection goals pertaining to their regions.

  2. Basel accord and financial intermediation: The impact of policy

    Berka, Martin; Zimmermann, Christian

    2012-01-01

    This paper studies loan activity in a context where banks must follow Basel Accord-type rules and acquire financing from households. Loan activity typically decreases when entrepreneurs’ investment returns decline, and we study which type of policy could revigorate an economy in a trough. We find that active monetary policy increases loan volume even when the economy is in good shape; introducing active capital requirement policy can be effective as well if it implies tightening of regulation...

  3. REPEATABILITY OF THE FRENCH HIGHER VEGETATION TYPES ACCORDING

    G. GRANDJOUAN; Brisse, H.; P. DE RUFFRAY

    1998-01-01

    Higher vegetation types are generally determined by successive approximations and defined by a common consent. Instead, they might be statistically determined and repeated, according to a numerical method called ‘socio-ecology’. This method deals only with floristical data, but gives them an ecological meaning by a previous calibration of the relations between plants, computed as ecological indices. It is applied to a pair of two homologous samples, each having 2.000 relev...

  4. Examination of Human Psychological Needs according to Islamic Teachings

    Hassan Rezaee Haftador; Eshaq Hoseyni Koohsari

    2015-01-01

    Every day, mental illnesses bring about significant economic, social, and personal loss. It is for this reason that investigation of human psychological needs is essential. Failure to meet these needs may result in mental disorder. Keeping the psyche healthy and securing peace of mind are some of the main concerns of monotheistic religions, especially Islam. The psychological needs of human beings addressed in the teachings of Islam are examined in the present study. According to Islamic teac...

  5. Glycemic Targets in Diabetes Care: Emerging Clarity after Accord

    Buse, John B.

    2015-01-01

    Through the 1990s convincing evidence emerged from studies involving relatively recent onset diabetes that glycemic control achieving glycated hemoglobin A1c levels of approximately 7% was associated with improved microvascular outcomes. Based on advocacy groups' statements encouraging lower targets and recognition of cardiovascular disease as the leading cause of death in diabetes, the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study was funded in 1999 to explore more intensi...

  6. Analysis of reinforced concrete building according to the EC 8

    Dimec, Andrej

    2009-01-01

    In the Thesis the analysis and the software based design of the six-storey reinforced concrete wall building according to the European Standard Eurocode is presented. The structural system of the building consists of reinforced concrete walls. First the calculation of the self weight, variable actions, snow and the wind loads has been examined. The major part of the thesis deals with seismic analysis, which was performed by the modal analysis and simplified non-linear seismic a...

  7. Design of CGP administrative building according to Eurocode standards

    Pavlin, Rožle

    2012-01-01

    This thesis presents the designing of the administrative building of CGP according to the current Eurocode standards in the field of constructions. Reinforced concrete construction consists of two parts which are separated with dilatation. The focus is on the part of the building that was built in 2007 and consists of the basement, the ground floor, two floors and the attic. The load-bearing construction of this five-storey building consists of monolith reinforced concrete plates and walls of...

  8. Financial reporting according to IFRS in Oil and Gas Industry

    Shagatay, Samal

    2012-01-01

    The main tasks of work is to study the properly reflection of business transactions on accounting accounts in the oil and gas enterprises and their further reflection in the financial statements in accordance with IFRS, the timely recognition of revenues and expenses of the organization. Industry structure, types of oil and gas assets, evaluation and impairment methods, cost accounting and other specific aspects of the industry are described in the work. The work contains a number of solved e...

  9. Biomotor Structures in Elite Female Handball Players According to Performance

    Čavala, Marijana; Rogulj, Nenad; Srhoj, Vatromir; Srhoj, Ljerka; Katić, Ratko

    2008-01-01

    In order to identify biomotor structures in elite female handball players, factor structures of morphological characteristics and basic motor abilities, and of variables evaluating situation motor abilities of elite female handball players (n=53) were determined first, followed by determination of differences and relations of the morphological, motor and specific motor space according to handball performance. Factor analysis of 16 morphological measures produced three morphologica...

  10. Behavioral and emotional problems of schoolchildren according to gender

    Adriana Martins Saur; Sonia Regina Loureiro

    2014-01-01

    The aim of this study was to investigate mental health problems, including behavioral and emotional problems, in a cohort of schoolchildren according to gender and to assess the associations of family characteristics and behavioral performance for boys and girls. Data from 677 children born in Ribeirão Preto (SP), Brazil, when they were 10/11 years old was available. The mental health assessment was performed using the Brazilian version of the Strengths and Difficulties Questionnaire. Results...

  11. Prediction of Addiction Potential in Youth According to Personality Trait

    Mahdiyeh Adrom; Zahra Nikmanesh

    2012-01-01

    Bakground: The aim of this study was to predict the psychological tendency to drug abuse in youths according to their personality characteristics.Materials and Method: The research sample includes male and female students of Zahedan Medical Science University with the average age of 19-24years. The proportional cluster random sampling was used for selection of participants. The hypotheses were analyzed, using Pearson correlation method, regression analysis, one way ANOVA and t- test for two i...

  12. Dosimetry of 64Cu-DOTA-AE105, a PET tracer for uPAR imaging

    (predicted value: 0.0252 mSv/Mbq, Observed value: 0.0315 mSv/MBq) thus validating our approach for human dosimetry estimation. Conclusion: Favorable dosimetry estimates together with previously reported uPAR PET data fully support human testing of 64Cu-DOTA-AE105

  13. Wage differences according to health status in France.

    Ben Halima, Mohamed Ali; Rococo, Emeline

    2014-11-01

    Many OECD countries have implemented anti-discrimination laws in recent decades. However, according to the annual report published in 2010 by the French High Authority for the Fight against Discrimination and for Equality, the second most commonly cited factor in discrimination claims since 2005 is a handicap or health status. The aim of this research is to estimate the level of unexplained components in the wage gap that can be attributed to wage discrimination based on health status in France in 2010 utilizing data from the Health, Healthcare and Insurance survey among 1594 individuals. Three health indicators are used: self-perceived health status, activity limitations and long-term chronic illness. To measure the wage gap according to an individual's health status, the analysis considers the endogenous selection of health status and unobserved differences in productivity. The results demonstrate that wage discrimination is experienced by individuals in poor health regardless of the health indicator utilized. The hourly wage rate among individuals with poor self-assessed health status is on average 14.2% lower than among individuals with good self-assessed health status. However, for individuals suffering from a long-term chronic illness or an activity limitation, the gap is 6.3% and 4.5%, respectively. The decomposition performed on wage differences according to health status by correcting for health status selection bias and controlling for unobserved differences in productivity indicates that the 'unexplained component' that can be attributed to wage discrimination is equal to 50%. PMID:25262313

  14. KSHV-Mediated Regulation of Par3 and SNAIL Contributes to B-Cell Proliferation

    Jha, Hem C.; Sun, Zhiguo; Upadhyay, Santosh K.; El-Naccache, Darine W.; Singh, Rajnish K.; Sahu, Sushil K.; Robertson, Erle S.

    2016-01-01

    Studies have suggested that Epithelial–Mesenchymal Transition (EMT) and transformation is an important step in progression to cancer. Par3 (partitioning-defective protein) is a crucial factor in regulating epithelial cell polarity. However, the mechanism by which the latency associated nuclear antigen (LANA) encoded by Kaposi's Sarcoma associated herpesvirus (KSHV) regulates Par3 and EMTs markers (Epithelial-Mesenchymal Transition) during viral-mediated B-cell oncogenesis has not been fully explored. Moreover, several studies have demonstrated a crucial role for EMT markers during B-cell malignancies. In this study, we demonstrate that Par3 is significantly up-regulated in KSHV-infected primary B-cells. Further, Par3 interacted with LANA in KSHV positive and LANA expressing cells which led to translocation of Par3 from the cell periphery to a predominantly nuclear signal. Par3 knockdown led to reduced cell proliferation and increased apoptotic induction. Levels of SNAIL was elevated, and E-cadherin was reduced in the presence of LANA or Par3. Interestingly, KSHV infection in primary B-cells led to enhancement of SNAIL and down-regulation of E-cadherin in a temporal manner. Importantly, knockdown of SNAIL, a major EMT regulator, in KSHV cells resulted in reduced expression of LANA, Par3, and enhanced E-cadherin. Also, SNAIL bound to the promoter region of p21 and can regulate its activity. Further a SNAIL inhibitor diminished NF-kB signaling through upregulation of Caspase3 in KSHV positive cells in vitro. This was also supported by upregulation of SNAIL and Par3 in BC-3 transplanted NOD-SCID mice which has potential as a therapeutic target for KSHV-associated B-cell lymphomas. PMID:27463802

  15. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Hong-hua Peng

    2012-01-01

    Full Text Available The matrix metalloprotease-1 (MMP-1/protease-activated receptor-1 (PAR-1 signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC, we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9% and 58 (68.2% tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS than those with negative ESCC (P = 0.002 and 0.003, respectively. Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR = 2.836, 95% confidence interval (CI = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068, MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127, and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883 and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681, MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279, and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881 as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  16. Monitoreo de parásitos en efluentes domiciliarios

    Liliana Semenas

    1999-08-01

    Full Text Available OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente 2 de las 6 muestras de semisólidos analizadas tenían huevos de Ascaris lumbricoides no viables. De las 10 muestras líquidas, solamente 2 no tenían huevos mientras las restantes tenían patógenos de las categorías I (Giardia sp., Hymenolepis diminuta y Enterobius vermicularis y III (Ascaris lumbricoides, Ancylostoma duodenale y Trichuris trichiura. CONCLUSIONES: Todas las muestras de semisólidos analizadas fueron aptas para su uso como fertilizantes porque no se registró en ninguna de ellas la presencia de huevos viables de Ascaris lumbricoides y solamente 6 de las muestras líquidas fueron aptas para riego por carecer de huevos o por ser su concentración igual o inferior a 1 huevo por litro.

  17. Monitoreo de parásitos en efluentes domiciliarios

    Semenas Liliana

    1999-01-01

    Full Text Available OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente 2 de las 6 muestras de semisólidos analizadas tenían huevos de Ascaris lumbricoides no viables. De las 10 muestras líquidas, solamente 2 no tenían huevos mientras las restantes tenían patógenos de las categorías I (Giardia sp., Hymenolepis diminuta y Enterobius vermicularis y III (Ascaris lumbricoides, Ancylostoma duodenale y Trichuris trichiura. CONCLUSIONES: Todas las muestras de semisólidos analizadas fueron aptas para su uso como fertilizantes porque no se registró en ninguna de ellas la presencia de huevos viables de Ascaris lumbricoides y solamente 6 de las muestras líquidas fueron aptas para riego por carecer de huevos o por ser su concentración igual o inferior a 1 huevo por litro.

  18. Los parásitos de los animales domésticos.

    Cruz B. Luis

    2012-01-01

    Desde el año 1937, el Departamento Nacional de Agricultura, desean prestar un servicio más efectivo para el agricultor costarricense, viene publicando en su Revista Agrícola, artículos referentes a los parásitos que infestan nuestro ganados e incluyendo siempre las medidas más prácticas para su control. Durante muchos años, los parásitos de los animales han constituido un verdadero flagelo para la industria costarricense, entorpeciendo su progreso; pero desde que el Servicio de Par...

  19. Influence of P-Reactor operation on the aquatic ecology of Par Pond: a literature review

    Par Pond is a 1012 hectare reservoir that was constructed in 1958 to provide cooling water for Savannah River nuclear reactors. The purpose of this report is to summarize all known studies on the Par Pond system and point out demonstrable or probable effects that can be correlated with reactor operations. Reactor operation effects the Par Pond ecosystem through: (1) pumping, (2) thermal alteration, and (3) the addition of Savannah River makeup water. The influence of each of these factors is discussed. 108 references, 24 figures, 34 tables. (MF)

  20. Recruitment of the ParG Segregation Protein to Different Affinity DNA Sites▿ §

    Zampini, Massimiliano; Derome, Andrew; Bailey, Simon E. S.; Barillà, Daniela; Hayes, Finbarr

    2009-01-01

    The segrosome is the nucleoprotein complex that mediates accurate plasmid segregation. In addition to its multifunctional role in segrosome assembly, the ParG protein of multiresistance plasmid TP228 is a transcriptional repressor of the parFG partition genes. ParG is a homodimeric DNA binding protein, with C-terminal regions that interlock into a ribbon-helix-helix fold. Antiparallel β-strands in this fold are presumed to insert into the OF operator major groove to exert transcriptional cont...

  1. Sécurité et immigration : vers une gouvernementalité par linquiétude ?

    Bigo, Didier

    2006-01-01

    L'immigration est lue à travers le prisme de la sécurité par certains hommes politiques, par les polices et certains services sociaux, par nombre de journalistes et une fraction de l'opinion publique. Malgré les critiques fréquentes et argumentées d'une telle perception, malgré l'existence de discours alternatifs, cette lecture continue, très largement, d'être dominante. Pourquoi ? Qu'est ce qui pousse tous ces acteurs à faire un lien entre crime, chômage, terrorisme, fanatisme et migration ?...

  2. Platelet–leukocyte aggregation induced by PAR agonists: regulation by nitric oxide and matrix metalloproteinases

    Chung, Ada W Y; Radomski, Anna; Alonso-Escolano, David; Jurasz, Paul; Stewart, Michael W; Malinski, Tadeusz; Radomski, Marek W

    2004-01-01

    Platelet–leukocyte aggregation (PLA) links haemostasis to inflammation. The role of nitric oxide (NO) and matrix metalloproteinases (MMP-1, -2, -3, -9) in PLA regulation was studied.Homologous human platelet–leukocyte suspensions were stimulated with thrombin (0.1–3 nM) and other proteinase activated receptor-activating peptides (PAR-AP), including PAR1AP (0.5–10 μM), PAR4AP (10–70 μM), and thrombin receptor-activating peptide (1–35 μM).PLA was studied using light aggregometry with simultaneo...

  3. Recuit thermique rapide de semi-conducteur par énergie micro-onde

    Covas, M.; Gay, H.

    1993-01-01

    Nous proposons une méthode de recuit thermique rapide du silicium par énergie micro-onde. Cette technique offre les mêmes avantages que les traitements thermiques rapides par lumière incohérente, c'est-à-dire des durées de chauffage très brèves, limitant ainsi la diffusion des dopants, et un traitement plaquette par plaquette : les risques de contamination de tout un lot sont ainsi éliminés. De plus notre méthode requiert une faible énergie : pour parvenir à des recuits de qualité similaire à...

  4. Downregulation of uPAR and Cathepsin B Retards Cofilin Dephosphorylation

    Christopher S Gondi; Kandhukuri, Neelima; Kondraganti, Shakuntala; Gujrati, Meena; Olivero, William C.; Dinh, Dzung H.; Rao, Jasti S.

    2006-01-01

    Cathepsin B and uPAR play key roles in cancer cell migration and invasion. Here, we demonstrate that the simultaneous, siRNA-mediated downregulation of uPAR and cathepsin B inhibits glioma cell migration and is accompanied by cytoskeletal condensation. We show that the dephosphorylation of cofilin is inhibited by the downregulation of uPAR alone and, to a lesser extent, by the downregulation of cathepsin B alone, and that the effect was much higher by the downregulation of both molecules by p...

  5. Research axes and conclusions

    Laugier, F.; Pirotton, M.; Reverchon, B.; Schleiss, Anton; Erpicum, S.; Boillat, Jean-Louis

    2011-01-01

    The aim of this short paper is to summarize main outcomes of the workshop, in order to guide future developments of research on Piano Key Weirs (PKW) towards most effective and integrated directions. The main research topics highlighted in this text came out from the 34 high-quality presentations given during the conference, as well as from the fruitful discussions in which the participants were actively involved. Many more truly innovative and promising ideas can be found throughout the othe...

  6. Prospects and conclusion

    The present issue of 'Les Cahiers de COGEMAGAZINE', dedicated to role played by Cogema in the nuclear fuel cycling, ends with a short account on perspectives and concluding considerations. In the world nuclear fuel industry the most active zones appear to be France, Japan, China, Taiwan and Korea. A real expansion is to be expected in UO2 market for PWRs. Also rapid development will be recorded by the production of MOF (mixed oxide fuels) especially due to the inception of British reprocessing plant at Thorp and the increase of number of MOF-fuelled reactors. The most significant lines of progress related to the new fuels are estimated to be: high burn-up (by increasing the resistance to fission gas pressure and irradiation), improvement of response to power excursions, fuel matrices of stronger retention, increase in the plutonium content of MOF, 100% MOF-fuelled reactors, optimizing the utilization of consumable poisons (for PWR) and very high burn-up and very long service lifetimes (for Breeders). In a nuclear environment, now in a rather low expansion rate, the French nuclear fuel industry enjoys the benefit of: an important national market, industrial experimented teams able to tackle all the steps from design to realization of a diversity of nuclear fuel types, fabrication facilities combining suppleness to clients' demands with requirements for high quality, a highly-rated worldwide position, and important capabilities of technological further development. An annex is added showing the percentage involvement of COGEMA and FRAMATOME in the fields of UO2-PuO2 fuel production for PWR, fuels for Breeder, WER and experimental reactors and transport. Also participation of other European companies like PECHINEY, BELGONUCLEAIRE and SIEMENS is indicated

  7. The Cramster Conclusion

    Grams, Michael

    2011-01-01

    In a recent "TPT" article, I wrote about a website called "Cramster" (www.cramster.com), which provides students with solutions to homework problems from many textbooks in math and science. I proposed the following question: Could giving students the answers to their assigned homework problems be an effective way of teaching them physics? This…

  8. Summary and conclusions

    Rao, D.G.; Murthy, K.S.R.; Neprochnov, Y.P; Subrahmanyam, C.

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  9. Conclusion. Chapter 4

    Beginning 1992, January 1 Semipalatinsk test site was transforming into large research scientific center. The National Nuclear Center (NNC) was formed on the base of site's research enterprises. The principal problems of NNC are as follows: liquidation of nuclear tests consequences; liquidation of technological infrastructure for preparation and conducting of nuclear tests, creation of technology for radioactive wastes store; implementation of atomic energy development conception in Kazakhstan, etc. Program of site conversion constantly is expanding. In this chapter measures by rehabilitation of injured population are revealed. Taking into account radioecological situation, dose loadings, demographic indexes, sick rate and mortality of population on territories exposed to site's influence Government of Kazakhstan adopted Decree on declaration of these lands of zone of ecological catastrophe. Measures on improvement of radioecological situation are reduce to following ones: determination of irradiation doses received by population during testing period; study of existing radiation contamination; study of all possible sources for dose increasing and taking into account other ones; information of population about radioecological situation and about all consequences of nuclear tests. In 1992 Supreme Soviet of Republic of Kazakhstan worked out and adopted law On social defence of citizens suffered from consequences of nuclear tests on Semipalatinsk test site. It was distinguished four zones of radiation risk. The first zone is zone of extreme risk. It is part of territory subjected to radiation contamination with dose of influence on population above 100 rem during of total period of tests conducting. To this zone belong following inhabited settlements: Budene, Dolon', Cheremushki, Mostik, Sarzhal, Isa, Sarpan, Karakoryk, Zagotskot-2. Second zone is zone of maximal radiation risk. To this zone belong inhabited settlements of following districts: Abaj, Abraly, Beskargaj and Zana-Semej. Population of these districts have been exposed to ionizing radiation influence in doses from 35 up to 100 rem. Third zone is zone of increased risk. To this zone belong inhabited settlements of following districts of Semipalatinsk region: Chybartau, Novo-Shul'ba, Borodulikha, Charsk, Zharmy, Ayaguz. Effective equivalent doses for population during all these years made up from 7 to 35 rem. Forth zone is zone of minimal radiation risk. To this zone the inhabited settlements of Makanchi, Urdzhary, Taskesken, Kokpekty, Aksuat districts belongs. Effective equivalent doses of population irradiation made up from 0.1 to 7 rem. Measures on compensation payment for caused harm to suffered peoples health in result of nuclear weapon test have been carried out with taking into consideration of living duration in different zones

  10. Out of Conclusion

    Dalsgaard, Anne Line; Frederiksen, Martin Demant

    2013-01-01

    Based on long-term fieldwork in Northeast Brazil and the Republic of Georgia, this article explores how open-endedness can be incorporated into ethnographic analysis and writing, not as the empirical object, but as a basic condition for our knowledge production. In the empirical contexts that we...... describe, daily life is marked by poor prospects and lack of possibility, especially for young people. Rather than letting this guide our analyses and ways of writing, this article argues for the necessity of paying attention to the openness and potential of experienced moments of change. We propose that...

  11. Instead of a conclusion

    In this interview Mr. Paolo Ruzzini (Chairman and CEO, Slovenske elektrarne, a. s., a member of ENEL) evaluates the decision of ENEL to complete the construction Unit-3 and Unit-4 of the Mochovce nuclear power plant. He argues that 'in the market conditions and without government subsidies, we are ready to continue developing the project - the construction of the Unit-3 and Unit-4 of the Mochovce NPP'.

  12. Geomagnetic field: Conclusions

    Gorodnitsky, A; Subrahmanyam, A

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  13. Conclusion and outlook

    Some topics related to the status and prospects for future research in heavy ion reaction physics are discussed. Topics include: fission of nuclei with large angular momentum, pre-equilibrium light particle emission, origin of pre-equilibrium light particles, projectile fragmentation, equilibrium times for fragment excitation energy and angular momentum degrees of freedom in damped collisions, dependence of giant dipole strength function on spin and excitation energy, discrete state structure studies, dinuclear molecular resonances, and will new phenomena emerge at E/A < 20 MeV/n. 47 references

  14. Instead of a Conclusion

    Dosenrode, Søren

    The findings of the book are summarised and commented upon. The concept of 'martyrdom' and the reluctance in the use of violence are discussed......The findings of the book are summarised and commented upon. The concept of 'martyrdom' and the reluctance in the use of violence are discussed...

  15. Conclusion: The balanced company

    Scheuer, John Damm; Jensen, Inger

    2013-01-01

    This concluding chapter brings together the various research findings of the book "The balanced company - organizing for the 21st Century" and develops a general overview of their implications for our understanding of the balancing processes unfolding in companies and organizations....

  16. Conclusions and recommendations

    Schaik, van H.; Kabat, P.; Connor, R.

    2003-01-01

    Work will continue. The Water-and-Climate ball is rolling and there is a strong commitment to keep it going. This wrapup chapter contains a ten-point action agenda for countries, river basin authorities, regional organisations and the international development community. Contents: 6.1 Undeniable evi

  17. Methodologic Considerations and Conclusions

    Federica Chiesa

    2013-11-01

    Full Text Available After the theoric seasons of the second middle of the Twenthieth century especially by the anglo-american Scholars and the beginning of the open area excavations enterprises in Italy thirty years ago, the concept of the therm “method” holds now a multiplicity of aspects one another connected; their theorical and practical applications make valuable the method universality but it depends on the characteristics of the archaeological site too. So Nora with its historical-archaeological stratification is an exemplary specimen from a lot of points of view like a precious source to draw stratigraphical sequences inside  large chronological oasis with very important monumental contexts. The universitary équipes were allowed to adopt a modern methodological practice, founded on technological resources, that leads to a perspective which contains the archaeology of architecture and the archaeology of the smallest clue compared together. The fast and careful editions of the field-works in the “Quaderni Norensi” Collection, enriched by an exhaustive documentary evidence, constitutes an indispensable contribution to the reconstruction of the ancient town and the best trial to test a research model “open-area” between équipes differently formed but in a scientific homogeneous climate.

  18. Conclusions and Perspectives

    Mattysek, R.; Knoke, T.; Clarke, N.; Cudlín, Pavel; Mikkelsen, T. N.; Tuovinen, J.-P.; Wieser, G.; Paoletti, E.

    Amsterdam: Elsevier, 2013 - (Matyssek, R.; Clarke, N.; CudlÍn, P.; Mikkelsen, T.; Tuovinen, J.; Wieser, G.; Paoletti, E.), s. 591-607. (Developments in environmental science. 13). ISBN 978-0-08-098349-3 Institutional support: RVO:67179843 Keywords : ecosystem services * integrative modelling * policy making * research needs * supersites * synopsis Subject RIV: EH - Ecology, Behaviour

  19. 8. Summary and conclusions

    The crystal and magnetic structures of the intermetallic compounds of the type Th(Msub(1-x)M'sub(x))5 with M,M' = Fe, Co or Ni are discussed based on neutron diffraction experiments. As a function of x for Th(Fe, Co)5 and Th(Fe, Ni)5 ferro and antiferromagnetic components show up, while for Th(Co, Ni)5, for x above about 0.2, the ferromagnetic order changes to a ferrimagnetic order and the cell constants show a marked discontinuity. Different interpretations of these phenomena are discussed. Finally the magnetic properties of different ThFe compounds are discussed

  20. Finish: summary and conclusion

    Experimental results presented at the Leptonic Interactions session of the XIIth RENCONTRE DE MORIOND are reviewed, with emphasis on how they relate to the question of the existence of charm and heavy leptons