WorldWideScience

Sample records for accidental localised irradiations

  1. An ultrastructural and irradiation study of diffuse and localised kinetochore

    An electron microscope study of plant types Luzula nivea and Cyperus eragrostis with diffuse kinetochores and Crepis neglecta with localised kinetochore showed that Luzula has a rather different kinetochore organisation from Cyperus, with features approaching the localised type of Crepis. These studies included an examination of the ultrastructure of the kinetochore at metaphase at low magnification in control and irradiated material of Luzula; the chromosomal ultrastructure at high magnification at interphase and all stages of mitosis in Luzula, Cyperus and Crepis; and the ultrastructure of the nucleolus in Luzula, Cyperus and Crepis. Light microscopic studies were also performed showing the effects of irradiation on first mitotic division in Cyperus, Luzula and Crepis, mitotic aberrations in Cyperus and Crepis and meiosis in Cyperus. Finally, the survival with the diffuse as opposed to the localised kinetochore in M1 and M2 generations following seed irradiation was studied. (U.K.)

  2. Dose reconstruction in the case of localised irradiation with radiological burns

    When localised accidental irradiation occurs, it is necessary to determine the extent to which the tissue and vital organs have been damaged, mainly in the zone located near the source. At present, biological markets cannot be used to estimate the heterogeneousness of the dose, useful for devising the therapeutic strategy. An alternative would be to calculate the dose due to exposure in order to map the absorbed dose in the different regions of the organism. Our technique, combining Computer-Assisted Design (CAD) and Monte-Carlo calculation, can assess the dose distribution in a numerical anthropomorphic phantom fitted on the specific morphology of the victim. The CAD is used to simulate the accident, taking into account the specific morphology of the irradiated person, as well as the source and the environment of the accident. The Monte-Carlo code runs to transport photons and neutrons in this three-dimensional space, following a probabilistic method: each particle generated at the source and its interactions or energy losses along its path are calculated by reproducing faithfully the random nature of the interactions between particles and matter. The result of the calculation provides the relative absorbed dose distribution per source particle, so it has to be normalised in order to give the absolute value of the absorbed dose. The first way to get this data is straightforward if one knows both the activity of the source and the exposure time. However, in practice, the exposure time is very badly estimated, and even unknown. We propose a new approach to resolve this uncertainty. The technique consists in fitting the calculation results at one point where the absolute value of the absorbed dose is known or assessed. Different methods are proposed: the results are matched to the clinical signs of the lesion, particularly around the rim of the radiological necrosis, where the dose can be estimated to roughly 25 Gy. the whole-body dose assessed by the Monte

  3. Clinical and biological observations on seven accidentally irradiated algerian persons

    On may 5th 1978 an Ir 192 source of 15 Curies for gammagraphy set in a pencil-like holder fell from a truck on the road from Algiers to Setif. It was found 2 or 3 days later by two young boys 3 and 7 years old (AEK and RAB). They handled this bright metallic object for some hours. Later their Grandmother (Mrs ARA, 47 years old) took the source away from them, brought it into their house and hid it in the kitchen. The Iridium source remained for 6 weeks in this room where 5 persons were irradiated depending on various conditions of time, posture and dose rate. Two young female patients DJA (22 years old) and FMA (20 years old and pregnant) regularly frequented the working area of the kitchen at a distance of between 0.80 and 1.50 meters from the source which delivered a dose rate in the range of 8 Roentgen/hour at one meter. The exposure was estimated to be 6 to 8 hours daily. Two girls, FAH (17 years old) and NOU (19 years old) usually spent several hours in the kitchen doing their homework. After 4 weeks, the pregnant woman FMA suffered a malaise and decided to leave the house and go to another house. From this time on the two younger girls replaced FMA in the kitchen and were irradiated from 6 to 8 hours daily. Moreover, Mrs ARA, the Grandmother, came frequently into the kitchen and often leaned against the shelf where the source had been hidden and was thus often very close to it. The Algerian authorities looked actively for the missing and finally located it on June 12, 38 days after it had been lost. On June 14th, the seven injured persons were evacuated from Algiers to Paris where they were taken to the Curie Foundation Hospital (Dr. Jammet)

  4. Therapeutic approaches of hematopoietic syndrome after serious accidental global irradiation. Ex vivo expansion interest of hematopoietic cells

    Aplasia is one of the main syndrome, appearing after one global accidental irradiation by one ionizing radiation source. The hematopoietic syndrome is characterized by a peripheric blood cell number fall; the cell marrow is reduced too

  5. Localised vibrational mode spectroscopy studies of self-interstitial clusters in neutron irradiated silicon

    Londos, C. A.; Antonaras, G. [University of Athens, Solid State Physics Section, Panepistimiopolis Zografos, Athens 157 84 (Greece); Chroneos, A. [Materials Engineering, The Open University, Milton Keynes MK7 6AA (United Kingdom); Department of Materials, Imperial College, London SW7 2AZ (United Kingdom)

    2013-07-28

    The evolution of self-interstitial clusters in silicon (Si), produced by fast neutron irradiation of silicon crystals followed by anneals up to 750 °C, is investigated using localised vibrational mode spectroscopy. A band at 582 cm{sup −1} appears after irradiation and is stable up to 550 °C was attributed to small self-interstitial clusters (I{sub n}, n ≤ 4), with the most probable candidate the I{sub 4} structure. Two bands at 713 and 758 cm{sup −1} arising in the spectra upon annealing of the 582 cm{sup −1} band and surviving up to ∼750 °C were correlated with larger interstitial clusters (I{sub n}, 5 ≤ n ≤ 8), with the most probable candidate the I{sub 8} structure or/and with chainlike defects which are precursors of the (311) extended defects. The results illustrate the presence of different interstitial clusters I{sub n}, at the various temperature intervals of the material, in the course of an isochronal anneal sequence. As the annealing temperature increases, they evolve from first-order structures with a small number of self-interstitials (I{sub n}, n ≤ 4) for the temperatures 50 < T < 550 °C, to second order structures (I{sub n}, 5 ≤ n ≤ 8) with a larger number of interstitials, for the temperatures 550 < T < 750 °C.

  6. Dosimetric properties of textile fibers: application of electron paramagnetic resonance dosimetry to an accidental gamma irradiation

    The dosimetric properties of some twenty textile fibers have been studied in order to develop a method for determining the dose received in the case of an accidental gamma irradiation. Three textile fibers having properties most closely satisfying our needs were selected for detailed investigations: cotton, polypropylene and quartz. Electron Paramagnetic Resonance (EPR) readout techniques were used. In order to eliminate spectral anisotropy problems due to textile fiber inhomogeneities, a system has been developed to rotate samples in the resonant cavity during measurements. The structure, physical and chemical properties of cotton and polypropylene were investigated. A bibliographic study of the combined effects of light, heat and ionizing radiation on textile fibers was carried out. A linear relation exists between the EPR signal and the gamma ray dose received over a certain dose range. A method has been developed for preparing samples so as to reduce background noise not due to irradiation; in this way the detection threshold is lowered and a greater time stability obtained. Unknown doses corresponding to known spectra are determined by linear interpolation using a series of spectra obtained from the same fabric irradiated with known doses

  7. Therapeutic approaches of hematopoietic syndrome after serious accidental global irradiation. Ex vivo expansion interest of hematopoietic cells; Approches therapeutiques du syndrome hematopoietique apres irradiation globale accidentelle grave. Interet de l`expansion ex vivo des cellules hematopoietiques

    Thierry, D.

    1994-12-31

    Aplasia is one of the main syndrome, appearing after one global accidental irradiation by one ionizing radiation source. The hematopoietic syndrome is characterized by a peripheric blood cell number fall; the cell marrow is reduced too.

  8. The effects of acute irradiation on a forest biogeocenosis: Experimental data, model and practical applications for accidental cases

    The effects of acute irradiations of a mixed pine and birch forest in spring and autumn with a high power point-type gamma radiation source (1180 TBq 137Cs) have been described. Radiation dose relationships for numerous response reactions of woody and herbaceous plants (growth and development of organs of woody plants, cytogenetical, physiological and biochemical changes in trees, reproductive potential of plants, damage and dying off of the forest as a biogeocenosis on the whole) have been calculated. Post-radiation recovery of the forest was investigated. Changes involving the secondary reactions related to radiation damage and death of the trees are presented. A model for radiation damage of forests has been designed. Examples are given on the usage of this model in the description of radiation effects in forests in the event of accidental releases of radionuclides into environment

  9. Study and simulation of irradiated zirconium alloys fracture under type RIA accidental loading conditions

    The thesis aims to study and simulate the mechanical behavior under Reactivity Initiated Accident loading conditions, of the Zircaloy 4 fuel claddings, irradiated or not. It also aims to characterize and simulate the behavior and the fracture under RIA loading conditions of hydrided Zircaloy 4 non irradiated. This study proposes an experimental approach and a simulation. (A.L.B.)

  10. Ex vivo expansion of haematopoietic cells in the treatment of accidental irradiation-induced aplasia. Feasibility Studies

    haematopoietic cells for the treatment of accidental irradiation-induced aplasia. (author)

  11. Thermoluminescence properties of irradiated commercial color pencils for accidental retrospective dosimetry

    Color pencils are widely used mostly in kindergartens, in schools and could be found in all houses with families having young children. Their wide spread use in modern times as well as their chemical composition, consisting mostly of Si and Al, constitute two strong motivations towards exploiting their use as accidental retrospective thermoluminescent dosimeters. The present manuscript reports on the study of colored pencils manufactured by a commercial brand in China which is very common throughout Turkey. The preliminary results discussed in the present work illustrated encouraging characteristics, such as the presence of a trapping level giving rise to natural TL in a temperature range that is sufficiently high. Specific thermoluminescence features of this peak, such as glow peak shape and analysis, anomalous fading, thermal quenching, reproducibility, linearity and recovery ability to low attributed doses were studied. The results suggest that the color pencils could be effectively used in the framework of retrospective thermoluminescent dosimetry with extreme caution, based on multiple aliquot protocols. - Highlights: • Thermoluminescence of the inner part of commercial colored pencils was studied. • The presence of a trapping level giving rise to natural TL at 260 °C was yielded. • Deco analysis, anomalous fading, thermal quenching, reproducibility, linearity and recovery ability of this peak were studied

  12. The use of chromosomic anomalies for the estimation of an accidental acute irradiation dose in man

    The induction of chromosome abnormalities (dicentrics, rings and fragments) in human blood samples subjected to cobalt 60 gamma irradiation was studied for 11 doses varying from 25 to 1800 rads. The chromosome aberrations were counted in lymphocytes after 48 hours of in vitro culture. The results obtained from the observation of 6400 cells made it possible to establish dose-effect relationships for each types of abnormality (dicentrics, dicentrics and rings, and fragments). The dose-effect relationships were used to estimate doses received by 9 workers submitted to relatively homogeneous global acute irradiation and for which an evaluation of the average absorbed dose was possible. There is in general a good agreement between the estimation of the average absorbed dose based on chromosome damage and the physical dosimeter data. The study of the time-dependent evolution of the chromosome abnormalities in the lymphocytes of irradiated subjects shows that dosimetric estimations based on lymphocyte chromosome abnormalities in human blood are valid for several weeks after irradiation

  13. Study of a Case Involving Accidental Irradiation of a Human Being

    A description is given of an accident involving extremely uneven irradiation (ranging from 50 rads to 1.7 Mrads), in which a worker carried a 137Cs source belonging to an industrial gamma radiography unit in his trouser pockets for a total period of 18 hours on 3 and 4 May 1968. Low irradiation of the haematopoietic and gastrointestinal organs inhibited the occurrence of the acute syndrome. The front of the thighs, the inguinoscrotal region, and to a lesser extent the hands, were the areas most affected by lesions. The radiation doses delivered to the affected areas were estimated from biological radiation dosimetry parameters (the extent and chronological order of some of the lesions) and from experimental data on the dose as a function of distance and depth of the tissues, obtained by reconstructing the accident with a phantom and a set of thermoluminescent dosimeters. The paper describes the appearance a few days later of wet radiation dermatitis covering areas which gradually grew until they reached approximately the limit represented by the 1000 rads isodose line. Progression of the radiation dermatitis was complete towards the end of May. At the beginning of June dry epidermal desquamation extending approximately as far as the 500 rads line was observed. With the passage of time there occurred muscular atrophy of both legs and extensive oedema of the inguinoscrotal area. The appearance of extensive femoral haemorrhages in November 1968 and January 1969 made it necessary to amputate first the lower left limb, and then the right. The rate of chromosomal aberrations in the peripheral blood confirms the low doses absorbed by the blood system (about 50 rads). A summary of results of the analyses made is given, together with comments on the prognosis of the patient's development, based on the distribution of the radiation dose received. (author)

  14. Part of the oxidative stress in the development of radio-induced cell effects at cutaneous level: application to accidental localised irradiations

    The objective of our study was to answer to the following questions: does the initial radio-induced oxidative stress lead to the accumulation of DNA damages in the low renewal cells (fibroblasts, endothelial cells) that could be responsible of delayed effects; does it exist delayed oxidative phenomena and era they implied in the delayed effects arising; does it exist a phenomenon of premature senescence; does it exist a premature senescence phenomenon that could lead to an accumulation of damages before the cell death; what are the action mechanisms of the association pentoxifylline/α-tocopherol. (N.C.)

  15. Control of domain wall pinning by localised focused Ga + ion irradiation on Au capped NiFe nanowires

    Understanding domain wall pinning and propagation in nanowires are important for future spintronics and nanoparticle manipulation technologies. Here, the effects of microscopic local modification of the magnetic properties, induced by focused-ion-beam intermixing, in NiFe/Au bilayer nanowires on the pinning behavior of domain walls was investigated. The effects of irradiation dose and the length of the irradiated features were investigated experimentally. The results are considered in the context of detailed quasi-static micromagnetic simulations, where the ion-induced modification was represented as a local reduction of the saturation magnetization. Simulations show that domain wall pinning behavior depends on the magnitude of the magnetization change, the length of the modified region, and the domain wall structure. Comparative analysis indicates that reduced saturation magnetisation is not solely responsible for the experimentally observed pinning behavior.

  16. Therapeutic potential of ex vivo expansion of haematopoietic precursors for the treatment of accidental irradiation-induced aplasia

    After whole body overexposure, the key issue is the therapeutic decision, i.e. the choice between bone marrow transplantation and other strategies. The indications of bone marrow transplantation cover only a short range of doses, provided the exposure is distributed uniformly within the body; a rare event in accidental settings. The results of the clinical trials for Granulocyte-Colony Stimulating Factor: G-CSF, Granulocyte/Macrophage Colony Stimulating Factor: GM-CSF or Interleukin 3: IL-3, in vivo and in vitro radiobiology experiments suggest that growth factor therapy could be of use after most accidental overexposures to evidence and to stimulate the remaining haematopoietic stem cells in order to shorten the duration of aplasia, although questions have been raised about growth factor infusion real clinical efficiency. Ex vivo expansion of haematopoietic precursor, stem cells and differentiated cells is a new approach of growth factor therapy, which may be of interest for the treatment of patients with accidental radiation-induced aplasia. These studies aim to expand the pool of progenitors and stem cells for transplantation or to expand differentiated cells (mainly granulocytes but also megakaryocytes) for transfusion. This is made possible due to the development of techniques allowing the selection of a population of haematopoietic progenitors and stem cells from the blood (with stimulation by growth factors prior stem cell harvesting) or bone marrow using immature cell positive selection. The next step consisting in their culture with combination of growth factors or additional stroma cells is also under development. Autologous progenitor cells generated ex vivo has been recently used with some success for reconstitution of haematopoiesis after high-dose chemotherapy. (author)

  17. Research on the use of microwave thermography in the case of an acute irradiation of pig; the interest of this experimental model for the diagnosis and assessment of an accidental irradiation of man. Final report for the period 1 March 1984 - 30 September 1989

    Thermography, x-ray tomography and NMR imaging, and scintigraphy have been used for the early diagnosis of an acute localized irradiation of a pig. The combination of these methods allows the evaluation of the radiation injury and its possible evolution. The methods could be applied to detect an accidental irradiation of man. 2 refs

  18. Accidental Innovation

    Austin, Robert D.; Devin, Lee; Sullivan, Erin E.

    2012-01-01

    Historical accounts of human achievement suggest that accidents can play an important role in innovation. In this paper, we seek to contribute to an understanding of how digital systems might support valuable unpredictability in innovation processes by examining how innovators who obtain value from...... they incorporate accidents into their deliberate processes and arranged surroundings. By comparing makers working in varied conditions, we identify specific factors (e.g., technologies, characteristics of technologies) that appear to support accidental innovation. We show that makers in certain specified...... conditions not only remain open to accident but also intentionally design their processes and surroundings to invite and exploit valuable accidents. Based on these findings, we offer advice for the design of digital systems to support innovation processes that can access valuable unpredictability....

  19. Energy localisation and transfer

    Dauxois, Thierry; MacKay, Robert; Spanoudaki, Anna

    2004-01-01

    This book provides an introduction to localised excitations in spatially discrete systems, from the experimental, numerical and mathematical points of view. Also known as discrete breathers, nonlinear lattice excitations and intrinsic localised modes, these are spatially localised time periodic motions in networks of dynamical units. Examples of such networks are molecular crystals, biomolecules, and arrays of Josephson superconducting junctions. The book also addresses the formation of discrete breathers and their potential role in energy transfer in such systems. Contents: Computational Stud

  20. Hematopoiesis stimulation test by interleukin 1α gene transfer in the Cynomolgus macaque: application to secondary medullary aplasia from an accidental irradiation

    After a description of the context of medullary aplasia (haematological radiobiology, radiation acute syndrome, therapeutic care), and an overview of knowledge about the interleukin-1 and medullary stroma cells, this research thesis aims at investigating therapeutic alternatives for radio-accidental aplasia. More precisely, it aims at defining means to get cytokines which are efficient for haematopoiesis. Interleukin-1 is chosen for its properties and tests are performed on a macaque with two approaches for gene transfer: an ex vivo transfer by retroviral vector enabling an integration in the target cell genome, and an in situ transfer by adeno-viral vector directly applied in the animal osseous medulla

  1. Feasibility of high-dose three-dimensional radiation therapy in the treatment of localised non-small-cell lung cancer; Irradiation conformationelle de haute dose dans les cancers bronchiques non a petites cellules localement evolues: etude de faisabilite

    Belliere, A.; Girard, N.; Chapet, O.; Khodri, M.; Kubas, A.; Mornex, F. [Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Dept. de Radiotherapie-Oncologie, 69 - Pierre-Benite (France); Souquet, P.J. [Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Dept. de Medecine Respiratoire, 69 - Pierre-Benite (France)

    2009-07-15

    Purpose/ Chemoradiotherapy is the standard treatment of inoperable and/or non-resectable IIIA/B non-small-cell lung cancer (N.S.C.L.C.). Aware of the necessity to increase local control in locally advanced N.S.C.L.C., we analyzed the feasibility of high-dose three-dimensional conformal radiation therapy (3D-C.R.T.) in the treatment of localised N.S.C.L.C. Patients and methods: We undertook a retrospective analysis of consecutive patients with non-resectable N.S.C.L.C. treated with high-dose (74 Gy) standard-fractionation 3D-C.R.T., with particular attention to the relationship between lung and heart radiation-induced toxicities. Results: Fifty patients (41 males, 9 females) were included. A total of 35 (70%) patients received the planned total dose of 74 Gy. Patients irradiated to inferior doses interrupted the treatment because of limiting toxicities. Induction and concurrent chemotherapy was delivered to 39 (78%) and 14 (28%) patients, respectively. Eight (16%) patients experienced grade 3-4 acute lung toxicity, all of them having a history of pulmonary disease, a FEV1 below 1.6 L, and a lung V20 of at least 25%. Three (6%) patients were deemed to experience radiation-induced cardiac toxicity. Conclusions: This study assesses the feasibility of delivering a total dose of 74 Gy combined with chemotherapy in locally advanced N.S.C.L.C.. High lung and heart V20 increases the risk of radiation-induced lung and cardiac toxicity, the later being highly difficult to precisely assess, as late deaths are rarely documented, and responsibility of the treatment might be often underestimated. The precise evaluation of cardiac condition may be helpful to spare fragile patients from potentially toxic effects of high-dose radiation, especially in controlled trials. (authors)

  2. Radiative accidental matter

    Sierra, D Aristizabal; Wegman, D

    2016-01-01

    Accidental matter models are scenarios where the beyond-the-standard model physics preserves all the standard model accidental and approximate symmetries up to a cutoff scale related with lepton number violation. We study such scenarios assuming that the new physics plays an active role in neutrino mass generation, and show that this unavoidably leads to radiatively induced neutrino masses. We systematically classify all possible models and determine their viability by studying electroweak precision data, big bang nucleosynthesis and electroweak perturbativity, finding that the latter places the most stringent constraints on the mass spectra. These results allow the identification of minimal radiative accidental matter models for which perturbativity is lost at high scales. We calculate radiative charged-lepton flavor violating processes in these setups, and show that $\\mu\\to e \\gamma$ has a rate well within MEG sensitivity provided the lepton-number violating scale is at or below $10^6\\,$ GeV, a value (natur...

  3. Localisation in Quantum Field Theory

    Balachandran, A P

    2016-01-01

    In nonrelativistic quantum mechanics , Born's principle of localisation is as follows: For a single particle, if a wave function $\\psi_K$ vanishes outside a spatial region $K$, it is said to be localised in $K$. In particular if a spatial region $K'$ is disjoint from $K$, a wave function $\\psi_{K'}$ localised in $K'$ is orthogonal to $\\psi_K$. Such a principle of localisation does not exist compatibly with relativity and causality in quantum field theory (Newton and Wigner) or interacting point particles (Currie,Jordan and Sudarshan).It is replaced by symplectic localisation of observables as shown by Brunetti, Guido and Longo, Schroer and others. This localisation gives a simple derivation of the spin-statistics theorem and the Unruh effect, and shows how to construct quantum fields for anyons and for massless particles with `continuous' spin. This review outlines the basic principles underlying symplectic localisation and shows or mentions its deep implications. In particular, it has the potential to affect...

  4. Study and simulation of irradiated zirconium alloys fracture under type RIA accidental loading conditions; Comprehension et modelisation de la rupture d'alliages de zirconium irradies en conditions accidentelles de type RIA

    Le Saux, M. [CEA Saclay, Dept. des Materiaux pour le Nucleaire (DEN/DANS/DMN/SEMI), 91 - Gif-sur-Yvette (France)

    2008-07-01

    The thesis aims to study and simulate the mechanical behavior under Reactivity Initiated Accident loading conditions, of the Zircaloy 4 fuel claddings, irradiated or not. It also aims to characterize and simulate the behavior and the fracture under RIA loading conditions of hydrided Zircaloy 4 non irradiated. This study proposes an experimental approach and a simulation. (A.L.B.)

  5. Radiative accidental matter

    Sierra, D. Aristizabal; Simoes, C.; Wegman, D.

    2016-07-01

    Accidental matter models are scenarios where the beyond-the-standard model physics preserves all the standard model accidental and approximate symmetries up to a cutoff scale related with lepton number violation. We study such scenarios assuming that the new physics plays an active role in neutrino mass generation, and show that this unavoidably leads to radiatively induced neutrino masses. We systematically classify all possible models and determine their viability by studying electroweak precision data, big bang nucleosynthesis and electroweak perturbativity, finding that the latter places the most stringent constraints on the mass spectra. These results allow the identification of minimal radiative accidental matter models for which perturbativity is lost at high scales. We calculate radiative charged-lepton flavor violating processes in these setups, and show that μ → eγ has a rate well within MEG sensitivity provided the lepton-number violating scale is at or below 5×105 GeV, a value (naturally) assured by the radiative suppression mechanism. Sizeable τ → μγ branching fractions within SuperKEKB sensitivity are possible for lower lepton-number breaking scales. We thus point out that these scenarios can be tested not only in direct searches but also in lepton flavor-violating experiments.

  6. Localisation of corneal foreign bodies.

    Kay-Wilson, L. G.

    1992-01-01

    Of 50 patients attending the eye casualty department with a corneal foreign body (FB), 41 were able to say where they felt the FB and 78% of these were localised correctly for side or level of cornea. Patient handedness did not influence FB location. Indicating the upper lid was a particularly poor guide to localisation, whereas FB sensations within the palpebral fissure, in the lower lid or medially or laterally were good guides to actual FB location. A simple method of recording FB location...

  7. Braneworld localisation in hyperbolic spacetime

    Crampton, B; Stelle, K S

    2014-01-01

    We present a construction employing a type IIA supergravity and 3-form flux background together with an NS5-brane that localises massless gravity near the 5-brane worldvolume. The nonsingular underlying type IIA solution is a lift to 10D of the vacuum solution of the 6D Salam-Sezgin model and has a hyperbolic ${\\cal H}^{(2,2)}\\times S^1$ structure in the lifting dimensions. A fully back-reacted solution including the NS5-brane is constructed by recognising the 10D Salam-Sezgin vacuum solution as a "brane resolved through transgression." The background hyperbolic structure plays a key r\\^ole in generating a mass gap in the spectrum of the transverse-space wave operator, which gives rise to the localisation of gravity on the 6D NS5-brane worldvolume, or, equally, in a further compactification to 4D. Also key to the successful localisation of gravity is the specific form of the corresponding transverse wavefunction Schr\\"odinger problem, which asymptotically involves a $V=-1/(4\\rho^2)$ potential, where $\\rho$ is...

  8. Accidental gamma dose measurement using commercial glasses.

    Narayan, Pradeep; Vaijapurkar, S G; Senwar, K R; Kumar, D; Bhatnagar, P K

    2008-01-01

    Commercial glasses have been investigated for their application in accidental gamma dose measurement using Thermoluminescent (TL) techniques. Some of the glasses have been found to be sensitive enough that they can be used as TL dating material in radiological accident situation for gamma dosimetry with lower detection limit 1 Gy (the dose significant for the onset of deterministic biological effects). The glasses behave linearly in the dose range 1-25 Gy with measurement uncertainty +/- 10%. The errors in accidental dose measurements using TL technique are estimated to be within +/- 25%. These glasses have shown TL fading in the range of 10-20% in 24 h after irradiation under room conditions; thereafter the fading becomes slower and reaches upto 50% in 15 d. TL fading of gamma-irradiated glasses follows exponential decay pattern, therefore dosimetry even after years is possible. These types of glasses can also be used as lethal dose indicator (3-4 Gy) using TL techniques, which can give valuable inputs to the medical professional for better management of radiation victims. The glasses are easy to use and do not require lengthy sample preparation before reading as in case of other building materials. TL measurement on glasses may give immediate estimation of the doses, which can help in medical triage of the radiation-exposed public. PMID:18285317

  9. Allegheny County Fatal Accidental Overdoses

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Fatal accidental overdose incidents in Allegheny County, denoting age, gender, race, drugs present, zip code of incident and zip code of residence. Zip code of...

  10. Epidemiology of accidental radiation exposures.

    Cardis, E

    1996-01-01

    Much of the information on the health effects of radiation exposure available to date comes from long-term studies of the atomic bombings in Hiroshima and Nagasaki. Accidental exposures, such as those resulting from the Chernobyl and Kyshtym accidents, have as yet provided little information concerning health effects of ionizing radiation. This paper will present the current state of our knowledge concerning radiation effects, review major large-scale accidental radiation exposures, and discu...

  11. Towards a theory of optimal localisation

    Jonathan Flowerdew

    2015-02-01

    Full Text Available All practical ensemble-based atmospheric data assimilation (DA systems use localisation to reduce the damaging impact of spurious long-range correlations arising from the finite ensemble size. However, the form of the localisation function is generally ad-hoc, and requires expensive tuning to optimise the system. For the case of a single observation and known true background error correlation, we derive an expression for the localisation factor that minimises the expected root-mean-square (RMS analysis error. Idealised tests show this formulation performs well for multiple observations provided their density is not too high. The width of the optimal localisation function scales with the width of the underlying correlation, but does not have the same shape. The optimal observation-space localisation for a single spatially integrating observation depends on the observation-to-gridpoint background error correlation, making it broader than the optimal localisation for point observations and potentially competitive with model-space localisation. A new form of hybrid DA is proposed in which localisation damps the sample correlations towards their climatological mean rather than zero, reducing the RMS error and potentially improving the dynamic balance of the analysis. The presence of variance errors causes the optimal localisation factor to depend on the ratio of observation to background error variance, and raises the possibility that a small amount of variance damping may be beneficial. For dense observations, a more elaborate theory is required, which will almost certainly depend on the observation network. We present some preliminary analysis of the features of the multi-observation problem, which for instance suggests that the optimal solution may involve different localisation factors in the numerator and denominator of the Kalman filter equation. We note that even optimal localisation gives an expected RMS error which exceeds that of perfect DA

  12. Multimodal localisation : analysis, algorithms and experimental evaluation

    Muthukrishnan, Kavitha

    2009-01-01

    The term localisation is derived from the word locale, which traditionally means a small area or vicinity. In ancient days, localisation meant navigation -- an art of finding the way from one place to another. Tremendous advancement in the science of navigation dates back to the sixteenth century, w

  13. Accidental degeneracies in string compactification

    Bais, F.A.; Taormina, A.

    1986-11-27

    The equivalence of the torus and group manifold compactification of strings is established. Accidental degeneracies are shown to occur for a large class of compactifications. This way many examples are obtained in which modular invariance does not uniquely fix the representation content of the spectrum.

  14. Accidental degeneracies in string compactification

    Bais, F. A.; Taormina, A.

    1986-11-01

    The equivalence of the torus and group manifold compactification of strings is established. Accidental degeneracies are shown to occur for a large class of compactifications. This way many examples are obtained in which modular invariance does not uniquely fix the representation content of the spectrum.

  15. Accidente de Trabajo y Recargo

    Pérez Alonso, María Antonia

    2015-01-01

    En la actualidad existen diferentes formas de Accidente de Trabajo. En el presente trabajo se da a conocer las distintas formas y la doctrina de los tribunales. Se aborda el recargo de prestaciones de Seguridad Social y el deber del empresario en cumplir la normativa de Seguridad Social

  16. Radiotherapy with curative objective in the localised prostate adenocarcinomas occurring after eighty years. A study of the Rare Cancer Network

    The radiotherapy delivered in a curative aim is well tolerated among patients aged eighty years or more. The results in term of survival suggest that the lack of negative impact of irradiation. The authors wish that the modern techniques of irradiation are not systematically inadvisable among patients with localised prostate cancer. (N.C.)

  17. Part of the oxidative stress in the development of radio-induced cell effects at cutaneous level: application to accidental localised irradiations; Role du stress oxydatif dans le developpement des effets cellulaires radio-induits au niveau cutane: application aux irradiations localisees accidentelles

    Carine, Laurent

    2005-10-15

    The objective of our study was to answer to the following questions: does the initial radio-induced oxidative stress lead to the accumulation of DNA damages in the low renewal cells (fibroblasts, endothelial cells) that could be responsible of delayed effects; does it exist delayed oxidative phenomena and era they implied in the delayed effects arising; does it exist a phenomenon of premature senescence; does it exist a premature senescence phenomenon that could lead to an accumulation of damages before the cell death; what are the action mechanisms of the association pentoxifylline/{alpha}-tocopherol. (N.C.)

  18. Stochastic metastability by spontaneous localisation

    Nonequilibrium, quasi-stationary states of a one-dimensional “hard” ϕ4 deterministic lattice, initially thermalised to a particular temperature, are investigated when brought into contact with a stochastic thermal bath at lower temperature. For lattice initial temperatures sufficiently higher than those of the bath, energy localisation through the formation of nonlinear excitations of the breather type during the cooling process occurs. These breathers keep the nonlinear lattice away from thermal equilibrium for relatively long times. In the course of time some breathers are destroyed by fluctuations, allowing thus the lattice to reach another nonequilibrium state of lower energy. The number of breathers thus reduces in time; the last remaining breather, however, exhibits amazingly long life-time demonstrated by extensive numerical simulations using a quasi-symplectic integration algorithm. For the single-breather states we have calculated the lattice velocity distribution unveiling non-Gaussian features describable in a closed functional form. Moreover, the influence of the coupling constant on the life-time of a single breather has been explored. The latter exhibits power-law behaviour as the coupling constant approaches the anticontinuous limit

  19. C.T. - guided percutaneous biopsy localisation

    CT guided percutaneous biopsy procedures are being performed with increasing frequency to provide specimens for cytologic analysis when small deeply positioned or inaccessible lesions within the body are suspected of malignancy. The localisation techniques employed are discussed

  20. Multimodal localisation : analysis, algorithms and experimental evaluation

    Muthukrishnan, Kavitha

    2009-01-01

    The term localisation is derived from the word locale, which traditionally means a small area or vicinity. In ancient days, localisation meant navigation -- an art of finding the way from one place to another. Tremendous advancement in the science of navigation dates back to the sixteenth century, when instruments like compasses, sextants and the first ever clock to keep the time exactly were devised. Advancement in navigation brought ways and means to explore the world, be it for expansion o...

  1. Geographical localisation of the geomagnetic secular variation

    Aubert, Julien; Finlay, Chris; Olsen, Nils

    2013-01-01

    Directly observed changes in Earth’s magnetic field occur most prominently at low latitudes beneath the Atlantic hemisphere, while the Pacific is comparatively quiet. This striking hemispheric asymmetry in geomagnetic secular variation is a consequence of the geographical localisation of intense...... control from either, or both, the inner-core boundary and the core-mantle boundary. In addition to presenting an Earth-like magnetic field morphology, these new numerical models also reproduce the morphology and localization of geomagnetic secular variation. In our models, the conservation of the angular...... thermochemical boundary control distorts this gyre (the strongest distortion being obtained with inner core heterogeneous control) and localises the field changes in a hemispherical longitudinal sector. The two effects combine to recreate the observed localisation of geomagnetic secular variation in both...

  2. Track structure approach to the calculation of peak 5a to peak 5 (TLD-100) relative intensities following heavy charged particle irradiation

    A track structure approach to the calculation of the relative strength of localised and de-localised recombination mechanisms leading to composite glow peak 5 in LiF:Mg,Ti following heavy charged particle irradiation is described. (authors)

  3. Primary localised cutaneous amyloidosis - a systematic review

    Kaltoft, Britta; Schmidt, Grethe; Lauritzen, Anne Falensteen;

    2013-01-01

    Amyloidosis is defined as extracellular deposits of heterogenic, misfolded proteins, amyloid fibrils, in various tissues. The aim of our study was to review the literature and to evaluate the risk of developing systemic amyloidosis (SA) and the risk of local recurrence of primary localised...

  4. A Localised Corrosion Cell for Industrial Applications

    Andersen, A.; Hilbert, Lisbeth Rischel; Jansen, P.;

    2003-01-01

    The LOCORR-CELL™ developed by FORCE TECHNOLOGY is an electrochemical cell for industrial applications estimating localised corrosion. The cell is constructed in a carbon steel casing for direct mounting into the system. It is based on an oxygen concentration element reflecting the interaction...

  5. An incremental approach to automated protein localisation

    Kummert Franz

    2008-10-01

    Full Text Available Abstract Background The subcellular localisation of proteins in intact living cells is an important means for gaining information about protein functions. Even dynamic processes can be captured, which can barely be predicted based on amino acid sequences. Besides increasing our knowledge about intracellular processes, this information facilitates the development of innovative therapies and new diagnostic methods. In order to perform such a localisation, the proteins under analysis are usually fused with a fluorescent protein. So, they can be observed by means of a fluorescence microscope and analysed. In recent years, several automated methods have been proposed for performing such analyses. Here, two different types of approaches can be distinguished: techniques which enable the recognition of a fixed set of protein locations and methods that identify new ones. To our knowledge, a combination of both approaches – i.e. a technique, which enables supervised learning using a known set of protein locations and is able to identify and incorporate new protein locations afterwards – has not been presented yet. Furthermore, associated problems, e.g. the recognition of cells to be analysed, have usually been neglected. Results We introduce a novel approach to automated protein localisation in living cells. In contrast to well-known techniques, the protein localisation technique presented in this article aims at combining the two types of approaches described above: After an automatic identification of unknown protein locations, a potential user is enabled to incorporate them into the pre-trained system. An incremental neural network allows the classification of a fixed set of protein location as well as the detection, clustering and incorporation of additional patterns that occur during an experiment. Here, the proposed technique achieves promising results with respect to both tasks. In addition, the protein localisation procedure has been adapted

  6. Accidental inflation in the landscape

    We study some aspects of fine tuning in inflationary scenarios within string theory flux compactifications and, in particular, in models of accidental inflation. We investigate the possibility that the apparent fine-tuning of the low energy parameters of the theory needed to have inflation can be generically obtained by scanning the values of the fluxes over the landscape. Furthermore, we find that the existence of a landscape of eternal inflation in this model provides us with a natural theory of initial conditions for the inflationary period in our vacuum. We demonstrate how these two effects work in a small corner of the landscape associated with the complex structure of the Calabi-Yau manifold P4[1,1,1,6,9] by numerically investigating the flux vacua of a reduced moduli space. This allows us to obtain the distribution of observable parameters for inflation in this mini-landscape directly from the fluxes

  7. Recovery of infrastructure networks after localised attacks

    Hu, Fuyu; Yeung, Chi Ho; Yang, Saini; Wang, Weiping; Zeng, An

    2016-04-01

    The stability of infrastructure network is always a critical issue studied by researchers in different fields. A lot of works have been devoted to reveal the robustness of the infrastructure networks against random and malicious attacks. However, real attack scenarios such as earthquakes and typhoons are instead localised attacks which are investigated only recently. Unlike previous studies, we examine in this paper the resilience of infrastructure networks by focusing on the recovery process from localised attacks. We introduce various preferential repair strategies and found that they facilitate and improve network recovery compared to that of random repairs, especially when population size is uneven at different locations. Moreover, our strategic repair methods show similar effectiveness as the greedy repair. The validations are conducted on simulated networks, and on real networks with real disasters. Our method is meaningful in practice as it can largely enhance network resilience and contribute to network risk reduction.

  8. Comparing mobile robot localisation algorithms using Kalmtool

    Mogensen, Lars Valdemar; Hansen, Søren; Ravn, Ole;

    2009-01-01

    In this paper we present an estimation platform with simulation capabilities to evaluate methods for localisation of a mobile robot using a feature map. The platform is based on the Kalmtool 4 toolbox which is a set of MATLAB tools for state estimation of nonlinear systems. The toolbox contains f...... functions for extended Kalman filtering as well as for the DD1 filter and the DD2 filter. It also contains functions for Unscented Kalman filters as well as three versions of particle filters. The toolbox requires MATLAB version 7, but no additional toolboxes are required.......In this paper we present an estimation platform with simulation capabilities to evaluate methods for localisation of a mobile robot using a feature map. The platform is based on the Kalmtool 4 toolbox which is a set of MATLAB tools for state estimation of nonlinear systems. The toolbox contains...

  9. The Role of Localisation in Advertising Translation

    ZHANG Ying

    2016-01-01

    Today, a growing number of international corporations have been seeking to boost their sales on the global scale. To achieve this, adverting, one of the most common way to stimulate consumption, is widely used in which translation is involved because of diverse languages. Thus, how to translate a source advertising in a target culture has a decisive influence on a compa-ny’s marketing. The aim of the target advertising is to sell products to the locals. In this sense, localisation plays a significant role in the translation of advertising. This essay will discuss the importance of localisation in the translation of advertising and analyse cases of English-Chinese advertising translation based on the purpose of advertising and advertising translation.

  10. Localised Microwave Bursts During ELMs on MAST

    Freethy Simon

    2015-01-01

    Full Text Available Bursts of microwave emission are observed during ELM events on the Mega Ampère Spherical Tokamak. In agreement with observations on other machines, these bursts are up to 3 orders of magnitude more intense than the thermal background, but are electron cyclotron in nature. The peak in microwave emission is ~20μ before the peak in midplane Dα emission. Using the Synthetic Aperture Microwave Imaging radiometer, we are able to demonstrate that these bursts are often highly spatially localised and preferentially occur at the tokamak midplane. It is hypothesised that the localisation is a result of Doppler resonance broadening for electron Bernstein waves and the high perpendicular electron energies could be the result of pitch angle scattering in high collisionality regions of the plasma.

  11. Accidental Bolus of Parenteral Nutrition.

    Lodeserto, Frank; Al-Jaghbeer, Mohammed; Huang, David

    2016-08-01

    There is a paucity of data that exists regarding acute toxicity and management in the setting of parental nutrition (PN) overdose. We describe a case of a patient who received an accidental rapid bolus of PN and fat emulsion. She developed a seizure, metabolic acidosis, arrhythmias, myocardial ischemia, altered mental status, hypotension, and hypoxemia likely caused by elevated triglycerides, leading to a hyperviscosity syndrome. After failing standard therapy, she was successfully treated with a single-volume plasma exchange with resolution of symptoms. Fat emulsion or intravenous lipid emulsion and much of its safety have been recently described in its use as a rescue therapy in resuscitation from drug-related toxicity. Elevated serum triglyceride levels can result in a picture similar to a hyperviscosity syndrome. Plasma exchange is a known therapeutic modality for the management of hyperviscosity syndrome and a novel therapy in the treatment of hyperviscosity syndrome due to fat emulsion therapy. In a patient receiving PN with development of rapid deterioration of clinical status, without an obvious etiology, there should be consideration of PN overdose. A rapid assessment and treatment of severe electrolyte abnormalities should be undertaken immediately to prevent life-threatening cardiovascular and central nervous system collapse. If fat emulsion was rapidly coadministered and there are signs and symptoms of hyperviscosity syndrome, then consideration should be given to plasma exchange as an effective therapeutic treatment option. PMID:25666023

  12. SCANNING KELVIN PROBE APPLIED TO LOCALISED CORROSION

    Hussain, A.; Sk M. Haque

    2015-01-01

    This paper focuses on specific applications of the SKP system. The instrument is calibrated, using different thickness of a model polymer Poly Vinyl Butyral (PVB) on mild steel and on galvanised steel. Artificial defects are used to show how the instrument is capable of detecting a localised corrosion cell and its ability to picture the delamination of the coating from the steel substrate. An industrial application is undertaken with the instrument, where epoxy coated galvanised steel; with a...

  13. Engineering Design of Localised Synergistic Production Systems

    Leung Pah Hang, M; Martinez-Hernandez, E.; M. Leach; Yang, A.

    2015-01-01

    Centralised production of essential products and services based on fossil fuels and large scale distribution infrastructures have contributed to a plethora of issues such as deterioration of ecosystems, social-economic injustice and depletion of resources. The establishment of localised production systems can potentially reduce unsustainable resource consumption and bring socioeconomic and environmental benefits. The main objective of this work is to develop engineering tools for the rational...

  14. Guidelines on the medical therapy of persons accidentally overexposed to ionizing radiations. External contamination

    The document represents a guide for the external decontamination of persons accidentally radio contaminated due to the use, production or transport of radioactive materials. The general conditions, from the medical point of view, to be kept in mind, in the event of accidental overexposures as decontamination treatment and the handling of samples are detailed throughout report. The external contamination without injury in skin or with wound its considered. The distribution of measures and responsibilities for the therapy of the irradiated patients with radioactive materials are enumerated. The preparations of decontaminate solutions are detailed in this work. Moreover, forms for the reception, physical evaluation of the patient and external contamination are presented. (author)

  15. Hematopoiesis stimulation test by interleukin 1{alpha} gene transfer in the Cynomolgus macaque: application to secondary medullary aplasia from an accidental irradiation; Essais de stimulation de l'hematopoiese par le transfert de gene de l'interleukine-1{alpha} chez le macaque cynomolgus: application a l'aplasie medullaire secondaire a une irradiation accidentelle

    De Revel, Th.

    2002-12-15

    After a description of the context of medullary aplasia (haematological radiobiology, radiation acute syndrome, therapeutic care), and an overview of knowledge about the interleukin-1 and medullary stroma cells, this research thesis aims at investigating therapeutic alternatives for radio-accidental aplasia. More precisely, it aims at defining means to get cytokines which are efficient for haematopoiesis. Interleukin-1 is chosen for its properties and tests are performed on a macaque with two approaches for gene transfer: an ex vivo transfer by retroviral vector enabling an integration in the target cell genome, and an in situ transfer by adeno-viral vector directly applied in the animal osseous medulla

  16. Clinical study of lesions caused by accidental local exposure to ionizing radiations

    During the last few years the radiopathology service of the Curie Foundation has admitted more than a hundred patients who were followed and treated for irradiation or suspected irradiation after a work accident. Accidents followed by clinical symptoms account for about half the cases examined. Some of these clinical signs were benign whereas others developed very seriously, all possible conditions between these two extremes being represented. This report neglects cases of high total exposure and deals only with those of partial irradiation where local symptoms predominate, usually at the distal extremities of the upper limbs and exceptionally at the root or distal extremity of the lower limbs. Six clinical cases were selected as particularly revealing and are discussed below: accidental exposure of both hands to an iridium-192 source; chronic exposure to X-rays (left hand and right lower half-lip); accidental exposure of the right hand and antero-external face of the right thigh to a iridium-192 source; acute accidental exposure of the left hand to X-rays emitted under 50 kV; accidental exposure of both hands to cobalt-60 radiation; radiolesions of the left lower limb following a critical power excursion (gamma rays and neutrons)

  17. An accidental poisoning with mitragynine.

    Karinen, Ritva; Fosen, Jan Toralf; Rogde, Sidsel; Vindenes, Vigdis

    2014-10-24

    An increasing number of drugs of abuse are sold word wide over the internet. Names like "legal highs", "herbal highs" etc. give the impression that these are safe products, although the risk of fatal reactions might be substantial. Leaves from the plant Mitragyna speciosa, contain active compounds like mitragynine and 7-hydroxymitragynine. It has been reported that the potency of 7-hydroxymitragynine at the μ-opioid receptor is 30 times higher than that of mitragynine and 17 times higher than that of morphine. Case reports regarding poisoning with Kratom are reported, but the toxic or lethal ranges for the concentrations of the active substances have not been established, and concentrations of 7-hydroxymitragynine have not been reported previously. We present a case report where a middle aged man was found dead at home. The deceased had a history of drug abuse and mental illness for several years. At autopsy, there were no significant pathological findings. Post-mortem analysis of peripheral blood revealed: zopiclone 0.043mg/L, citalopram 0.36mg/L and lamotrigine 5.4mg/L, i.e. concentrations regularly seen after therapeutic ingestion of these drugs. Additionally mitragynine 1.06mg/L and 7-hydroxymitragynine 0.15mg/L were detected in blood and both also in urine. The high concentrations of mitragynine and 7-hydroxymitragynine indicate that the cause of death is intoxication by these substances; and the circumstances point toward the manner of death being accidental. We recommend that both mitragynine and 7-hydroxymitragynine are analyzed for in cases with suspected Kratom intoxication. PMID:25453780

  18. Mortalidad intrahospitalaria por accidente cerebrovascular

    Federico Rodríguez Lucci

    2013-08-01

    Full Text Available La mortalidad global por accidente cerebrovascular (ACV ha disminuido en las últimas tres décadas, probablemente debido a un mejor control de los factores de riesgo vascular. La mortalidad hospitalaria por ACV ha sido tradicionalmente estimada entre 6 y 14% en la mayoría de las series comunicadas. Sin embargo, los datos de ensayos clínicos recientes sugieren que esta cifra sería sustancialmente menor. Se revisaron datos de pacientes internados con diagnóstico de ACV del Banco de Datos de Stroke de FLENI y los registros institucionales de mortalidad entre los años 2000 y 2010. Los subtipos de ACV isquémicos se clasificaron según criterios TOAST y los ACV hemorrágicos en hematomas intrapanquimatosos, hemorragias subaracnoideas aneurismáticas, malformaciones arteriovenosas y otros hematomas intraparenquimatosos. Se analizaron 1514 pacientes, 1079 (71% con ACV isquémico (grandes vasos 39%, cardioembólicos 27%, lacunares 9%, etiología indeterminada 14%, otras etiologías 11% y 435 (29% con ACV hemorrágico (intraparenquimatosos 27%, hemorragia subaracnoidea 30%, malformaciones arteriovenosas 25% y otros hematomas espontáneos 18%. Se registraron 38 muertes intrahospitalarias (17 ACV isquémicos y 21 ACV hemorrágicos, representando una mortalidad global del 2.5% (1.7% en ACV isquémicos y 4.8% en ACV hemorrágicos. No se registraron muertes asociadas al uso de fibrinolíticos endovenosos. La mortalidad intrahospitalaria en pacientes con ACV isquémico y hemorrágico en nuestro centro fue baja. El manejo en un centro dedicado a las enfermedades neurológicas y el enfoque multidisciplinario por personal médico y no médico entrenado en el cuidado de la enfermedad cerebrovascular podrían explicar, al menos en parte, estos resultados.

  19. SCANNING KELVIN PROBE APPLIED TO LOCALISED CORROSION

    A. Hussain

    2015-01-01

    Full Text Available This paper focuses on specific applications of the SKP system. The instrument is calibrated, using different thickness of a model polymer Poly Vinyl Butyral (PVB on mild steel and on galvanised steel. Artificial defects are used to show how the instrument is capable of detecting a localised corrosion cell and its ability to picture the delamination of the coating from the steel substrate. An industrial application is undertaken with the instrument, where epoxy coated galvanised steel; with an introduced defect in the coating and various added inhibitors. Chromates and chromate replacements have been studied.

  20. SCANNING KELVIN PROBE APPLIED TO LOCALISED CORROSION

    S. K. M. Haque

    2015-03-01

    Full Text Available This paper focuses on specific applications of the SKP system. The instrument is calibrated, using different thickness of a model polymer Poly Vinyl Butyral (PVB on mild steel and on galvanised steel. Artificial defects are used to show how the instrument is capable of detecting a localised corrosion cell and its ability to picture the delamination of the coating from the steel substrate. An industrial application is undertaken with the instrument, where epoxy coated galvanised steel; with an introduced defect in the coating and various added inhibitors. Chromates and chromate replacements have been studied.

  1. Coherent coupling between localised and propagating phonon polaritons

    Gubbin, Christopher R.; De Martini, Francesco; Politi, Alberto; Maier, Stefan A.; De Liberato, Simone

    2015-01-01

    Following the recent observation of localised phonon polaritons in user-defined silicon carbide nano-resonators, here we demonstrate coherent coupling between those localised modes and propagating phonon polaritons bound to the surface of the nano-resonator's substrate. In order to obtain phase-matching, the nano-resonators have been fabricated to serve the double function of hosting the localised modes, while also acting as grating for the propagating ones. The coherent coupling between long...

  2. To localise or to be localised with Wifi in the Hubei museum?

    Verbree, E.; Zlatanova, S.; Van Winden, K.; Van der Laan, E.B.; Makri, A.; Taizhou, L.; Haojun, A.

    2013-01-01

    Indoor localisation is in demand for a variety of applications within the built environment. An overall solution based on a single technology has not yet been determined. The aim of this paper is to gain insight on Signal Strength monitoring by a special kind of WiFi Monitors in comparison to the co

  3. Backreaction of Localised Sources in String Compactifications

    Junghans, Daniel

    2013-01-01

    Localised sources such as D-branes or orientifold planes play an important role in many string compactifications that are relevant for phenomenology. The presence of these objects typically induces complicated dynamics in the compact dimensions such that a full solution to the 10d equations of motion is often out of reach. In order to still be able to make statements about the 4d effective theory arising in the low-energy limit, the equations of motion are usually only solved in an integrated sense, while the backreaction of the localised sources on the internal fields is neglected. This simplification is often referred to as smearing. In this work, we investigate to what extent smearing may affect observables in the effective low-energy theory and whether it may lead to fake solutions that would cease to exist once the backreaction is properly taken into account. We analyse explicit examples for which smeared solutions exist and find that the reliability of the smeared approximation appears to depend on whet...

  4. Localised manifold learning for cardiac image analysis

    Bhatia, Kanwal K.; Price, Anthony N.; Hajnal, Jo V.; Rueckert, Daniel

    2012-02-01

    Manifold learning is increasingly being used to discover the underlying structure of medical image data. Traditional approaches operate on whole images with a single measure of similarity used to compare entire images. In this way, information on the locality of differences is lost and smaller trends may be masked by dominant global differences. In this paper, we propose the use of multiple local manifolds to analyse regions of images without any prior knowledge of which regions are important. Localised manifolds are created by partitioning images into regular subsections with a manifold constructed for each patch. We propose a framework for incorporating information from the neighbours of each patch to calculate a coherent embedding. This generates a simultaneous dimensionality reduction of all patches and results in the creation of embeddings which are spatially-varying. Additionally, a hierarchical method is presented to enable a multi-scale embedding solution. We use this to extract spatially-varying respiratory and cardiac motions from cardiac MRI. Although there is a complex interplay between these motions, we show how they can be separated on a regional basis. We demonstrate the utility of the localised joint embedding over a global embedding of whole images and over embedding individual patches independently.

  5. Periostitis and localised myositis in polyarteritis nodosa

    Full text: A 20-year-old man with previously diagnosed polyarteritis nodosa was referred for a bone scan to investigate longstanding knee and lower leg pain. The patient's symptoms worsened with any reduction of steroid dose and his physician was concerned about avascular necrosis of the hips. Plain x-rays of the lower limbs were normal. The blood pool images showed bilaterally increased activity in the anterior muscle compartments of the lower legs, suggestive of localised myositis. Three-hour delayed images showed widespread, increased subperiosteal activity with no evidence of avascular necrosis. Subsequent MRI scanning showed patchy muscle enhancement in both lower legs, also typical of myositis. A muscle biopsy was performed which demonstrated features of both myositis and vasculitis. The patient remains dependent on high-dose steroids for symptom relief. Localised myositis has previously been reported in polyarteritis nodosa and is a recognised, albeit rare, complication of the disorder, the basis of which is not well understood. Diagnostic muscle biopsy should be directed at involved muscle groups, which are best detected with MRI. Lower limb periostitis is well described in polyarteritis nodosa and may result in gross deformity. Several cases have previously been reported in the literature based on radiographic abnormalities, which were not present in our patient. Bone scanning demonstrated the sub-periosteal activity well in our subject and is suggested as a useful investigation in patients with polyarteritis nodosa who complain of lower limb pain. Copyright (2003) The Australian and New Zealand Society of Nuclear Medicine Inc

  6. Lung nodules accidentally detected on CT scans

    Improving of the spatial resolution of modern CT scanners has increased the amount of information obtained by lung CT, and thus the amount of accidentally determined nodules and quality of their structure specification. To unify the criteria of their follow-up CT studies Fleischner Society has issued recommendations for management of solid pulmonary nodules, and then added recommendations for subsolid nodules. In this article the review of categories of such accidental findings in lungs is presented with follow-up criteria and annotations applied

  7. Monitoring corrosion rates and localised corrosion in low conductivity water

    Hilbert, Lisbeth Rischel

    2006-01-01

    Monitoring of low corrosion rates and localised corrosion in a media with low conductivity is a challenge. In municipal district heating, quality control may be improved by implementing on-line corrosion monitoring if a suitable technique can be identified to measure both uniform and localised...

  8. Tuberculosis cutánea por inoculación accidental Cutaneous tuberculosis accidental inoculation

    María Ascensión Maestre Naranjo; Jenry Borda Olivas; Arantxa Ortega Hernández; Esmeralda Tovar Benito; María Luisa Rodríguez de la Pinta; Rosa María Daza Pérez

    2009-01-01

    Caso clínico de una microbióloga con amplia experiencia, que sufre una inoculación accidental al manipular una cepa pura de Mycobacterium tuberculosis. Se pincha en la cara lateral externa de la falange distal del dedo índice, atravesando el guante con la aguja contaminada. (Imagen 1). La trabajadora procede de forma inmediata a la limpieza de la herida. El Servicio de Prevención, registra la inoculación como accidente de trabajo. A las tres semanas del accidente, aparece en el lugar de la in...

  9. Localisation and World Modelling: an Architectural Perspective

    Domenico G. Sorrenti

    2008-11-01

    Full Text Available Autonomous robot world modelling is a "chicken-and-egg" problem: position estimation needs a model of the world, whereas world modelling needs the robot position. Most of the works dealing with this issue propose holistic solutions under an algorithmic perspective by neglecting software architecture issues. This results in huge and monolithic pieces of software where implementation details reify strategic decisions. An architectural approach founded on separation of concerns may help to break the loop. Localisation and modelling, acting on different time scales, are mostly independent of each other. Sometimes synchronisation is required. Whenever needed, an external strategy tunes the relative rates of the two activities. The paper introduces rationale, design, and implementation of such a system which relies on Real-Time Performers, a software architecture providing suitable architectural abstractions to observe and control the system's temporal behaviour.

  10. Reaction-Diffusion Automata Phenomenology, Localisations, Computation

    Adamatzky, Andrew

    2013-01-01

    Reaction-diffusion and excitable media are amongst most intriguing substrates. Despite apparent simplicity of the physical processes involved the media exhibit a wide range of amazing patterns: from target and spiral waves to travelling localisations and stationary breathing patterns. These media are at the heart of most natural processes, including morphogenesis of living beings, geological formations, nervous and muscular activity, and socio-economic developments.   This book explores a minimalist paradigm of studying reaction-diffusion and excitable media using locally-connected networks of finite-state machines: cellular automata and automata on proximity graphs. Cellular automata are marvellous objects per se because they show us how to generate and manage complexity using very simple rules of dynamical transitions. When combined with the reaction-diffusion paradigm the cellular automata become an essential user-friendly tool for modelling natural systems and designing future and emergent computing arch...

  11. Accidental fire in the West Hall

    1977-01-01

    On January 7 an accidental fire due to the failure of standard circuit-breakers, destroyed the coils of two spectrometer magnets and severely damaged the apparatus of two experiments. See also photos 7701582X, 7701581X, 7701580X. (Annual Report 1977, pg. 127-128)

  12. Medical handling of accidentally exposed individuals: recommendations

    The manual Medical Handling of Accidentally Exposed Individual, IAEA Safety Series no. 88 has been translated to portuguese language. Additional considerations about the Goiania radiological accident were incorporated to the original text, which provides knowledge involving health problems to both workers and public members. Also information concerning blood, recent radiological accidents, recommended maximum limited doses and a glossary were introduced. 5 refs

  13. To localise or to be localised with WiFi in the Hubei museum?

    Verbree, E.; Zlatanova, S.; van Winden, K. B. A.; van der Laan, E. B.; Makri, A.; Taizhou, L.; Haojun, A.

    2013-11-01

    Indoor localisation is in demand for a variety of applications within the built environment. An overall solution based on a single technology has not yet been determined. The aim of this paper is to gain insight on Signal Strength monitoring by a special kind of WiFi Monitors in comparison to the commonly known fingerprinting method for the purpose of a 3D indoor navigation system. Ttwo different WiFi based localisation techniques are tested during the MSc Geomatics DaRen Syntheses Project in the Hubei Provincial Museum, China. The first method detects the beacon frames send by smartphones, laptops and other WiFi enabled devices in range using Libelium Meshlium Xtreme monitors. Their MAC addresses and the signal strength is measured by the Meshlium Xtreme and stored on an external database. We call this method WiFi monitoring. The second method a Wifi enabled device, like a smartphone, measures the signal strength of multiple Wifi Access Points in range to localise itself based on a previously created radio map. This method is known as WiFi fingerprinting. Both methods have some advantages and disadvantages. Advantages of the common way of WiFi fingerprinting are that the implementation costs are relatively low, because it is usually possible to use (a part of) the existing WiFi AP infrastructure. WiFi fingerprinting can reach a relatively high accuracy in the order of magnitude of meters. Finally, the location granularity can be adjusted to what is necessary for the purpose of the indoor localisation. This makes it employable for a wide range of purposes. The question remains how suitable these methods are for a 3D indoor navigation system for the Hubei provincial museum. One important aspect is the localisation-granularity necessary for the application. In a museum it is not necessary to know the exact X,Y position of a user (such high accuracy is unnecessary), more important is to know in which room the user is located so the information on exhibitions can be

  14. Localisation et cartographie simultannées avec vision monoculaire

    Lemaire, Thomas

    2006-01-01

    Cette thèse aborde le problème de localisation et cartographie simultanée pour un robot mobile. Lorsque le robot évolue dans un environnement inconnu, il doit construire une carte au fur et à mesure qu'il explore le monde, tout en se localisant dans celle-ci. De l'anglais Simultaneous Localisation And Mapping, le SLAM est une brique essentielle de l'architecture d'un robot autonome. Plusieurs éléments sont nécessaires à la résolution du SLAM, en particulier la perception de l'environnement pe...

  15. Localisation of atomic populations in the optical radiation field

    The possibility of two-dimensional spatial localisation of atomic populations under the influence of the travelling wave fields in the tripod-configuration of quantum states is studied for the first time. Three travelling waves propagating in the same plane at an angle of 120° to each other form a system of standing waves under the influence of which atomic populations are localised. The size of the region of spatial localisation of the populations, in principle, can be hundredths of a wavelength of optical radiation. (quantum optics)

  16. Drosophila Syncrip binds the gurken mRNA localisation signal and regulates localised transcripts during axis specification

    Suzanne M. McDermott

    2012-04-01

    In the Drosophila oocyte, mRNA transport and localised translation play a fundamental role in axis determination and germline formation of the future embryo. gurken mRNA encodes a secreted TGF-α signal that specifies dorsal structures, and is localised to the dorso-anterior corner of the oocyte via a cis-acting 64 nucleotide gurken localisation signal. Using GRNA chromatography, we characterised the biochemical composition of the ribonucleoprotein complexes that form around the gurken mRNA localisation signal in the oocyte. We identified a number of the factors already known to be involved in gurken localisation and translational regulation, such as Squid and Imp, in addition to a number of factors with known links to mRNA localisation, such as Me31B and Exu. We also identified previously uncharacterised Drosophila proteins, including the fly homologue of mammalian SYNCRIP/hnRNPQ, a component of RNA transport granules in the dendrites of mammalian hippocampal neurons. We show that Drosophila Syncrip binds specifically to gurken and oskar, but not bicoid transcripts. The loss-of-function and overexpression phenotypes of syncrip in Drosophila egg chambers show that the protein is required for correct grk and osk mRNA localisation and translational regulation. We conclude that Drosophila Syncrip is a new factor required for localisation and translational regulation of oskar and gurken mRNA in the oocyte. We propose that Syncrip/SYNCRIP is part of a conserved complex associated with localised transcripts and required for their correct translational regulation in flies and mammals.

  17. Research progress in study of accidental hypothermia

    Yuan, Rui; Zhang, Zhi-cheng

    2016-01-01

    Accidental hypothermia refers to a state of lowering of core body temperature down to 35 ℃induced by drowning, burial in snow and prolonged exposure to cold environment, etc. Hypothermia may affect the cardiovascular system, respiratory system, digestive system, etc. The triad consisting "hypothermia, acidosis and coagulopathy" is an important factor accelerating the death of patients. Early, timely application of rewarming measures is regarded as the basic principle in treatment of hypotherm...

  18. Anaphylaxis after accidental ingestion of kiwi fruit

    Gawrońska-Ukleja, Ewa; Różalska, Anna; Ukleja-Sokołowska, Natalia; Żbikowska-Gotz, Magdalena; Bartuzi, Zbigniew

    2013-01-01

    Numerous cases of anaphylaxis after ingestion of kiwi fruit, after the skin tests and during oral immunotherapy were described. The article describes the case of severe anaphylactic reaction that occurred in a 55-year-old patient after accidental ingestion of kiwi. Allergy to kiwi fruit was confirmed by a native test with fresh kiwi fruit. After the test, the patient experienced generalized organ response in the form of headache, general weakness and rashes on the neck and breast, and dyspnea...

  19. Accidental swallowing of orthodontic expansion appliance key.

    Monini, André da Costa; Maia, Luiz Guilherme Martins; Jacob, Helder Baldi; Gandini, Luiz Gonzaga

    2011-08-01

    Ingestion of a foreign object, including a dental object, can lead to a trip to the emergency room. This article describes the accidental swallowing of a key that was used to activate a rapid maxillary expander. An orthodontic patient swallowed the key while trying to activate the appliance at home. The object's trajectory was followed on radiographs until it was eliminated. Possible clinical complications, legal implications of this situation, and practices for prevention are described. PMID:21803265

  20. Overlapping Zone Partitioning Localisation Technique for RFID

    Kavi K. Khedo

    2010-04-01

    Full Text Available Basically used for contactless identification, Radio Frequency Identification (RFID technology was originallythought as a complement for the drawbacks of the Barcode. Due to its capabilities and on-going drop in cost,researchers have started to look into other areas where RFID can be employed. One such area of research isReal-Time Location Tracking (RTLT, especially for indoor environments. While technologies such as Ultra-Sound, Infrared, WiFi, Bluetooth and GSM have been considered for indoor localisation, their requirements forline of sight and/or prohibitive cost have hindered their successful adoption. We are therefore presenting a lowcostsolution using RFID technology which we refer to as the ‘Overlapping Zone Partitioning’ (OZP techniquethat can be implemented using basic off-the-shelf RFID Readers and which has been derived from the zonebasedlocalisation technique. We have successfully implemented OZP and evaluated its performance. It hasbeen found that its accuracy is enhanced by nearly 40% in comparison to a normal zone-based localisationsystem. Its performance in terms of correct zone classification is within the range of 80-90%.

  1. Localised fibrous mesothelioma arising in an intralobar pulmonary sequestration.

    Paksoy, N.; Demircan, A.; Altiner, M; Artvinli, M

    1992-01-01

    A localised fibrous mesothelioma arising from an intralobar lung sequestration occurred in a 64 year old Turkish woman. This appears to be the first report of a mesothelioma occurring within a pulmonary sequestration.

  2. Computerised tomography localisation of intrarenal calculi prior to nephrolithotomy

    The use of the EMI CT 5005 scanner in patients with renal calculus disease is described. This investigation was found to be a useful aid in the accurate localisation of calculi within the renal collecting system prior to surgery. (author)

  3. Méthodes ensemblistes pour la localisation en robotique mobile

    Guyonneau, Rémy

    2013-01-01

    Cette thèse s'intéresse aux problèmes de localisation en robotique mobile, et plus particulièrement à l'intérêt d'une approche ensembliste pour ces problèmes. Actuellement les méthodes probabilistes sont les plus utilisées pour localiser un robot dans son environnement, cette thèse propose des approches alternatives basées sur l'analyse par intervalles. Dans un premier temps, une méthode ensembliste s'intéressant au problème de localisation globale est proposée. Le problème de localisation gl...

  4. Localisation et Cartographie Simultanées avec Vision Monoculaire

    Lemaire, Thomas

    2006-01-01

    This thesis tackles the Simultaneous Localisation And Mapping problem (SLAM for short). When the robot moves in an unknown environment, it has to incrementally build a map of the environment while using this map to localise itself. A SLAM algorithm is a fundamental part of the architecture of a fully autonomous robot. Several elements are required to solve SLAM, among which perception is of main importance since it produces observations of the objects of the environment (referred as landmarks...

  5. Indoor Localisation Based on GSM Signals: Multistorey Building Study

    Rafał Górak

    2016-01-01

    Full Text Available Among the accurate indoor localisation systems that are using WiFi, Bluetooth, or infrared technologies, the ones that are based on the GSM rely on a stable external infrastructure that can be used even in an emergency. This paper presents an accurate GSM indoor localisation system that achieves a median error of 4.39 metres in horizontal coordinates and up to 64 percent accuracy in floor prediction (for 84 percent of cases the floor prediction is mistaken by not more than a single floor. The test and reference measurements were made inside a six-floor academic building, with an irregular shape, whose dimensions are around 50 metres by 70 metres. The localisation algorithm uses GSM signal readings from the 7 strongest cells available in the GSM standard (or fewer, if fewer than 7 are available. We estimate the location by a three-step method. Firstly, we propose a point localisation solution (i.e., localisation based on only one measurement. Then, by applying the central tendency filters and the Multilayer Perceptron, we build a localisation system that uses a sequence of estimations of current and past locations. We also discuss major accuracy factors such as the number of observed signals or the types of spaces in the building.

  6. Newspaper: Files. Radiotherapy and accidental radiation protection. Scientific management between I.G.R. and I.P.S.N

    The Gustave-Roussy Institute (I.G.R.), the biggest european center of cancer treatment, and the Institute of Protection and Nuclear Safety (I.P.S.N.) that lead important researches and expertise in accidental radiation protection have established an agreement for a research program for six years. The objective is to speed up the researches in radio-pathology and radiobiology to improve the techniques used to treat the irradiated persons, for therapeutic or accidental reasons. Three principal themes have been chosen as starting point: Diagnosis and prognosis bio-indicators of irradiation effects on the digestive system, biological dosimetry and long term effects of a high dose irradiation. New themes will be tackled in function of the results or new needs. (N.C.)

  7. Clinical study of fetal liver transplantation in treatment of four cases of accidental or therapeutic acute radiation sickness

    This report summarized the clinical experience of fetal liver transplantation (FLT) in the medical handling of accidental (case 1) or therapeutic (cases 2-4) acute radiation sickness of severe haemopoietic form. In addition to receiving 80 mg/kg of cyclophosphamide, cases 2, 3 and 4 were exposed to total body single irradiation of 5.5, 5.0 and 5.0 Gy, respectively; while case 1 was exposed to whole body irradiation of 5.2 Gy only. The total number of nucleated fetal liver cells transplanted was 2.26-4.1 x 108/kg. Only 2-5% of peripheral blood cells of cases 2, 3 and 4 were found to have allogeneic marker. The author points out that FLT may be beneficial in those cases of accidental irradiation or patients with acute leukemia when there were no HLA-identical bone marrow donors available

  8. Localised hydrogen peroxide sensing for reproductive health

    Purdey, Malcolm S.; Schartner, Erik P.; Sutton-McDowall, Melanie L.; Ritter, Lesley J.; Thompson, Jeremy G.; Monro, Tanya M.; Abell, Andrew D.

    2015-05-01

    The production of reactive oxygen species (ROS) is known to affect the developmental competence of embryos. Hydrogen peroxide (H2O2) an important reactive oxygen species, is also known to causes DNA damage and defective sperm function. Current techniques require incubating a developing embryo with an organic fluorophore which is potentially hazardous for the embryo. What we need is a localised ROS sensor which does not require fluorophores in solution and hence will allow continuous monitoring of H2O2 production without adversely affect the development of the embryo. Here we report studies on such a fibre-based sensor for the detection of H2O2 that uses a surface-bound aryl boronate fluorophore carboxyperoxyfluor-1(CPF1). Optical fibres present a unique platform due to desirable characteristics as dip sensors in biological solutions. Attempts to functionalise the fibre tips using polyelectrolyte layers and (3-aminopropyl)triethoxysilane (APTES) coatings resulted in a limited signal and poor fluorescent response to H2O2 due to a low tip surface density of the fluorophore. To increase the surface density, CPF1 was integrated into a polymer matrix formed on the fibre tip by a UV-catalysed polymerisation process of acrylamide onto a methacrylate silane layer. The polyacrylamide containing CPF1 gave a much higher surface density than previous surface attachment methods and the sensor was found to effectively detect H2O2. Using this method, biologically relevant concentrations of H2O2 were detected, enabling remote sensing studies into ROS releases from embryos throughout early development.

  9. Localisation strategy for the South African nuclear power programme / Alden Willem Johan van Wyk

    Van Wyk, Alden Willem Johan

    2012-01-01

    Through this study, a strategy for the localisation and development of the South African nuclear industry was developed. As background, the Korean localisation experience was investigated, along with international recommendations regarding nuclear localisation, and South African governmental policies. This research was used as foundation for the formulation of a localisation strategy. The possibility of using localisation and nuclear industry development as a means to address governmental soc...

  10. Accidental Kähler moduli inflation

    We study a model of accidental inflation in type IIB string theory where inflation occurs near the inflection point of a small Kähler modulus. A racetrack structure helps to alleviate the known concern that string-loop corrections may spoil Kähler Moduli Inflation unless having a significant suppression via the string coupling or a special brane setup. Also, the hierarchy of gauge group ranks required for the separation between moduli stabilization and inflationary dynamics is relaxed. The relaxation becomes more significant when we use the recently proposed D-term generated racetrack model

  11. The accidental exposure to ionizing radiations

    This article is divided in three parts, the first one gives the radioactivity sources, the doses and the effects, the second part is devoted to the medical exposures, the third part concerns the accidents and the biological effects of an irradiation the different syndromes ( the acute whole-body irradiation syndrome, the localized irradiation syndrome, the inflammatory syndrome, hematopoietic syndrome,neuro-vascular syndrome) are detailed. (N.C.)

  12. Bayesian Joint Modelling for Object Localisation in Weakly Labelled Images.

    Shi, Zhiyuan; Hospedales, Timothy M; Xiang, Tao

    2015-10-01

    We address the problem of localisation of objects as bounding boxes in images and videos with weak labels. This weakly supervised object localisation problem has been tackled in the past using discriminative models where each object class is localised independently from other classes. In this paper, a novel framework based on Bayesian joint topic modelling is proposed, which differs significantly from the existing ones in that: (1) All foreground object classes are modelled jointly in a single generative model that encodes multiple object co-existence so that "explaining away" inference can resolve ambiguity and lead to better learning and localisation. (2) Image backgrounds are shared across classes to better learn varying surroundings and "push out" objects of interest. (3) Our model can be learned with a mixture of weakly labelled and unlabelled data, allowing the large volume of unlabelled images on the Internet to be exploited for learning. Moreover, the Bayesian formulation enables the exploitation of various types of prior knowledge to compensate for the limited supervision offered by weakly labelled data, as well as Bayesian domain adaptation for transfer learning. Extensive experiments on the PASCAL VOC, ImageNet and YouTube-Object videos datasets demonstrate the effectiveness of our Bayesian joint model for weakly supervised object localisation. PMID:26340253

  13. Accidentes de tránsito terrestre

    José Enrique Ramírez Muñoz

    2013-09-01

    Full Text Available Los accidentes de tránsito terrestres en Costa Rica se han convertido en un serio problema de salud pública, que derivan ya sea en lesiones graves o bien en muertes de personas de todas las edades. Estos eventos incluyen el atropellamiento, las colisiones y choques, y producen cuadros lesionológicos muy diversos de acuerdo a la participación de las personas, el tipo de vehículo y la forma en la que se produce el traumatismo. Así mismo, se debe tener en cuenta la participación de factores coadyuvantes como el uso del casco y el cinturón de seguridad, o bien el consumo de alcohol y el uso del teléfono móvil. La valoración médico legal de las víctimas, vivas o muertas de accidentes de tránsito, está a cargo del Departamento de Medicina Legal del Organismo de Investigación Judicial, y se hace por solicitud de una Autoridad Judicial competente.

  14. Medical management of accidentally exposed individuals

    Bone marrow aplasia is one of the main syndromes following a high dose accidental radiation exposure. Whilst transfusion and bone marrow transplantation have been used with some success starting with the first treatments of accident victims, other therapeutic strategies are needed. With the development of experimental and clinical haematology, promising new approaches to the treatment of aplasia have appeared. New trends for the treatment of haemopoietic injury based on bone marrow transplantation rely on new sources of compatible donor cells, such as cord blood, on the selection of immature haemopoietic cells and on new transplant regimens. Haemopoietic growth factors stimulate the proliferation and/or differentiation of haemopoietic progenitors and, possibly, stem cells. Furthermore, they act on the functions of mature cells. Currently, they have specific uses in haematology related to their role in the regulation of growth and in the differentiation of haemopoietic progenitor cells. Growth factors have already been used for the treatment of accidental radiation induced aplasia and lessons have been learned from their medical management and followup. (author)

  15. Medical management of accidentally exposed individuals

    Bone marrow aplasia is one of the main syndromes following a high dose accidental radiation exposure. Although both transfusion and bone marrow transplantation have been used with some success since the first treatments of patients, other therapeutic strategies are needed. New promising approaches of the treatment of aplasia have appeared with the development of experimental and clinical hematology. Some new trends for the treatment of the hematopoietic injury based on bone marrow transplantation rely on new sources of compatible donor cells, such as cord blood, on the selection of immature haemopoietic cells and on new transplant regimens. The hematopoietic growth factors stimulate proliferation and/or differentiation of hematopoietic progenitors and possibly stem cells. Furthermore, they act on the functions of mature cells. They have now specific uses in hematology, related to their role in the regulation of growth and differentiation of hematopoietic progenitor cells. Some growth factors have already been used for the treatment of accidental radiation-induced aplasia and lessons have been learned from their medical management and follow-up. (author)

  16. Accidental radioisotope burns - Management of late sequelae

    Varghese Bipin

    2010-10-01

    Full Text Available Accidental radioisotope burns are rare. The major components of radiation injury are burns, interstitial pneumonitis, acute bone marrow suppression, acute renal failure and adult respiratory distress syndrome. Radiation burns, though localized in distribution, have systemic effects, and can be extremely difficult to heal, even after multiple surgeries. In a 25 year old male who sustained such trauma by accidental industrial exposure to Iridium192 the early presentation involved recurrent haematemesis, pancytopenia and bone marrow suppression. After three weeks he developed burns in contact areas in the left hand, left side of the chest, abdomen and right inguinal region. All except the inguinal wound healed spontaneously but the former became a non-healing ulcer. Pancytopenia and bone marrow depression followed. He was treated with morphine and NSAIDs, epidural buprinorphine and bupivicaine for pain relief, steroids, antibiotics followed by wound excision and reconstruction with tensor fascia lata(TFL flap. Patient had breakdown of abdominal scar later and it was excised with 0.5 cm margins up to the underlying muscle and the wound was covered by a latissimis dorsi flap. Further scar break down and recurrent ulcers occurred at different sites including left wrist, left thumb and right heel in the next two years which needed multiple surgical interventions.

  17. Dosimetric significance of cytogenetic examinations in human accidental over exposures

    The damage to 13 workers following accidental exposures was assessed from lymphocyte chromosomal aberrations, and the results compared with those supplied by physical dosimetry and the clinical syndromes

  18. Localisation of beam offset jitter sources at ATF2

    Pfingstner, J; Patecki, M; Schulte, D; Tomás, R

    2014-01-01

    For the commissioning and operation of modern particle accelerators, automated error detection and diagnostics methods are becoming increasingly important. In this paper, we present two such methods, which are capable of localising sources of beam offset jitter with a combination of correlation studies and so called degree of freedom plots. The methods were applied to the ATF2 beam line at KEK, where one of the major goals is the reduction of the beam offset jitter. Results of this localisation are shown in this paper. A big advantage of the presented method is its high robustness especially to varying optics parameters. Therefore, we believe that the developed beam offset jitter localisation methods can be easily applied to other accelerators.

  19. Anderson localisation of visible light on a nanophotonic chip

    Crane, Tom; Sapienza, Luca

    2016-01-01

    Controlling the propagation of visible light on a chip is of tremendous interest in research areas such as energy harvesting, imaging, sensing and biology. Technological advances allow us to control light at the nanoscale and to strongly enhance the light-matter interaction in highly engineered devices. However, compared to state-of-the-art two-dimensional optical cavities operating at longer wavelengths, the quality factor of on-chip visible light confinement is several orders of magnitude lower. Our approach makes use of fabrication imperfections to trap light: we demonstrate, for the first time, Anderson localisation of visible light on a chip. Remarkably, compared to quality factors of engineered cavities, disorder-induced localisation proves to be more efficient in trapping light than highly engineered devices, thus reversing the trend observed so far. We measure light-confinement quality factors as high as 7600 and, by implementing a sensitive imaging technique, we directly visualise the localised modes...

  20. Experimental investigation of edge localised modes in JET

    Edge Localised Modes (ELMs) in the JET tokamak have been studied experimentally, using density profile and fluctuation data from a multichannel reflectometer and temperature profile data from an ECE heterodyne radiometer. The following topics have been investigated: The radial extent and localisation of the density and temperature profile perturbations caused by the ELMs. Fluctuations in the density and magnetic field in connection with the ELMs. The correlation between the repetition frequency of the L-H transition ELMs, and the plasma edge temperature and density. Trajectories in n-T space prior to ELMs later in the H-mode. (au) (39 refs.)

  1. Study of electron-irradiated silicon thin films using transient photocurrent spectroscopy

    Reynolds, S; Astakhov, O.; Smirnov, V.(Joint Institute for Nuclear Research, Dubna, Russia)

    2014-01-01

    Electron irradiation of silicon thin films creates localised states, which degrade theiropto-electronic properties. We present a series of transient photocurrent spectroscopy (TPC)measurements on electron-irradiated amorphous and microcrystalline silicon films, annealed atprogressively increasing temperatures. This has enabled localised states associated with bothdangling bonds and conduction band tails to be examined over a wide energy range.Trends inthe evolution of the DOS following electr...

  2. Accidental Turbulent Discharge Rate Estimation from Videos

    Ibarra, Eric; Shaffer, Franklin; Savaş, Ömer

    2015-11-01

    A technique to estimate the volumetric discharge rate in accidental oil releases using high speed video streams is described. The essence of the method is similar to PIV processing, however the cross correlation is carried out on the visible features of the efflux, which are usually turbulent, opaque and immiscible. The key step in the process is to perform a pixelwise time filtering on the video stream, in which the parameters are commensurate with the scales of the large eddies. The velocity field extracted from the shell of visible features is then used to construct an approximate velocity profile within the discharge. The technique has been tested on laboratory experiments using both water and oil jets at Re ~105 . The technique is accurate to 20%, which is sufficient for initial responders to deploy adequate resources for containment. The software package requires minimal user input and is intended for deployment on an ROV in the field. Supported by DOI via NETL.

  3. Throat-cutting of accidental origin.

    Demirci, Serafettin; Dogan, Kamil Hakan; Gunaydin, Gursel

    2008-07-01

    Incised wounds of the neck can be accidental, homicidal, or suicidal. In this paper, a death case has been presented where a spinning circular saw of a cutting machine in a workshop came off its place and cut the throat of a 30-year-old male who was operating the machine. There was an incision (15 cm x 5 cm) that began in the middle of the neck down the thyroid cartilage, extended horizontally to the left of the neck and ended on the outer part of the neck in the outer left side of m. trapezius. Death occurred because of exsanguination caused by the cutting of carotis artery and jugular vein. In the case we presented, although the cut in the neck initially suggested homicide, it was found to have occurred as a result of an accident after the autopsy and death scene investigation. PMID:18489556

  4. Research progress in study of accidental hypothermia

    Rui YUAN

    2016-04-01

    Full Text Available Accidental hypothermia refers to a state of lowering of core body temperature down to 35 ℃induced by drowning, burial in snow and prolonged exposure to cold environment, etc. Hypothermia may affect the cardiovascular system, respiratory system, digestive system, etc. The triad consisting "hypothermia, acidosis and coagulopathy" is an important factor accelerating the death of patients. Early, timely application of rewarming measures is regarded as the basic principle in treatment of hypothermia. A series of rewarming measures, such as infusion of warm fluids, inspiration of warm air, abdominal infusion of warm fluid, instruction of warm fluid into pleural cavity, intravenous infusion of warm fluid, rewarming through ECMO, etc. have been used recently. Advance in research on the classification of hypothermia, its impact to the body and the treatment methods are reviewed in present paper. DOI: 10.11855/j.issn.0577-7402.2016.04.15

  5. Accidental etizolam ingestion in a child.

    Kato, Zenichiro; Nakamura, Mitsuhiro; Funato, Michinori; Kuwabara, Hideaki; Kondo, Naomi

    2007-07-01

    Etizolam (ETZ) is an antidepressive thienodiazepine drug that is used worldwide. The most frequent adverse effects in adults are drowsiness and muscle weakness, and this can rarely cause paradoxical excitation; however, no information exists on intoxication in children. Furthermore, evidence bearing on its safety in children is not available. We present a case of a child who accidentally took a single dose of ETZ, approximately the same as a therapeutic dose for adults, and who showed paradoxical excitation and muscle weakness. The case presented here suggests that pediatricians and emergency physicians should be aware of the possible adverse effects in children and therapeutic approaches in intoxication of ETZ and the necessity of further investigations on a specific therapeutic guideline for overdose management especially in children. PMID:17666930

  6. Accidental foreign bodies in pediatric abdomens: A pictorial essay

    Foreign bodies in pediatric abdomens are caused by accidental ingestion or trauma. The purpose of this article is to review the various findings of accidental foreign bodies in pediatric abdomens. Abdominal radiography, fluoroscopic examination, gastrointestinal contrast studies and CT may be useful in evaluating the location and type of foreign body, and for evaluating complications such as bowel perforation and obstruction

  7. Accidental foreign bodies in pediatric abdomens: A pictorial essay

    Park, Chan Ho; Kim, Young Tong [Soonchunhyang Univ. Cheonan Hospital/Soonchunhyang Univ. College of Medicine, Cheonan (Korea, Republic of)

    2012-08-15

    Foreign bodies in pediatric abdomens are caused by accidental ingestion or trauma. The purpose of this article is to review the various findings of accidental foreign bodies in pediatric abdomens. Abdominal radiography, fluoroscopic examination, gastrointestinal contrast studies and CT may be useful in evaluating the location and type of foreign body, and for evaluating complications such as bowel perforation and obstruction.

  8. In normal human fibroblasts variation in DSB repair capacity cannot be ascribed to radiation-induced changes in the localisation, expression or activity of major NHEJ proteins

    Kasten-Pisula, Ulla; Vronskaja, Svetlana; Overgaard, Jens; Dikomey, Ekkehard

    2008-01-01

    . MATERIALS AND METHODS: Experiments were performed with 11 normal human fibroblast strains AF01-11. NHEJ proteins were determined by Western blot and DNA-PK activity by pulldown-assay. RESULTS: The four NHEJ proteins tested (Ku70, Ku80, XRCC4 and DNA-PKcs) were found to be localised almost exclusively in the...... the activity of the DNA-PK complex induced upon irradiation. CONCLUSIONS: For normal human fibroblasts, the level or activity of NHEJ proteins measured prior to or after irradiation cannot be used to predict the DSB repair capacity or cellular radiosensitivity. Udgivelsesdato: 2008-Mar......BACKGROUND AND PURPOSE: The aim of the present study was to test whether for normal human fibroblasts the variation in double-strand break (DSB) repair capacity results from radiation-induced differences in localisation, expression or activity of major non-homologous end-joining (NHEJ) proteins...

  9. AUTOMATIC LICENSE PLATE LOCALISATION AND IDENTIFICATION VIA SIGNATURE ANALYSIS

    Lorita Angeline

    2014-02-01

    Full Text Available A new algorithm for license plate localisation and identification is proposed on the basis of Signature analysis. Signature analysis has been used to locate license plate candidate and its properties can be further utilised in supporting and affirming the license plate character recognition. This paper presents Signature Analysis and the improved conventional Connected Component Analysis (CCA to design an automatic license plate localisation and identification. A procedure called Euclidean Distance Transform is added to the conventional CCA in order to tackle the multiple bounding boxes that occurred. The developed algorithm, SAICCA achieved 92% successful rate, with 8% failed localisation rate due to the restrictions such as insufficient light level, clarity and license plate perceptual information. The processing time for a license plate localisation and recognition is a crucial criterion that needs to be concerned. Therefore, this paper has utilised several approaches to decrease the processing time to an optimal value. The results obtained show that the proposed system is capable to be implemented in both ideal and non-ideal environments.

  10. Time Localisation of Surface Defects on Optical Discs

    Odgaard, Peter Fogh; Wickerhauser, M.V.

    Many have experienced problems with their Compact Disc player when a disc with a scratch or a finger print is tried played. One way to improve the playability of discs with such a defect, is to locate the defect in time and then handle it in a special way. As a consequence this time localisation is...

  11. Lung resection in cystic fibrosis patients with localised pulmonary disease.

    Lucas, J; Connett, G J; Lea, R.; Rolles, C J; Warner, J. O.

    1996-01-01

    The results of lobar resection to treat severe localised bronchiectasis in six children with cystic fibrosis are described. Sustained clinical improvements occurred in children undergoing this surgical approach to treatment. Detailed assessment and intensive preoperative and postoperative medical treatment are essential to a favourable outcome in carefully selected patients.

  12. Chinese Localisation of Evergreen: An Open Source Integrated Library System

    Zou, Qing; Liu, Guoying

    2009-01-01

    Purpose: The purpose of this paper is to investigate various issues related to Chinese language localisation in Evergreen, an open source integrated library system (ILS). Design/methodology/approach: A Simplified Chinese version of Evergreen was implemented and tested and various issues such as encoding, indexing, searching, and sorting…

  13. Therapeutic strategies for the treatment of accidental radiation-induced hematopoietic syndrome

    The hematopoietic syndrome induced by large field high dose accidental irradiation remains difficult to treat, mainly due to the heterogeneity of irradiation. As a result, there always remains an area of active hematopoiesis that was partly protected from irradiation. The choice of a therapeutic strategy thus must be based upon the estimate of radiation damage to the bone marrow. This can be achieved by the use of biological indicators of damage to specific organs. With this respect, we recently showed that the follow up of Flt3 ligand concentration in the blood allowed a direct evaluation of residual hematopoiesis soon after irradiation in animal models as well as in humans. Nevertheless, the possible therapeutic strategies available for the treatment of radiation-induced hematopoietic syndrome are limited to the choice between either stem cell transplantation or supportive care. Recently, the use of autologous cell therapy was proposed. The principle is to harvest the hematopoietic cells surviving to irradiation, to expand these cells in vitro and to re inject these cells to the patient. This is based upon the existence of a residual hematopoiesis and on the possibility to expand in vitro irradiated hematopoietic cells. Experimental work in a non human primate model of high-dose, heterogeneous irradiation showed that it was possible to harvest surviving hematopoietic cells after irradiation and to amplify these cells in vitro. However, the therapeutic efficiency of the reinjected cells was limited by the occurrence of a combined disease, implicating the lungs, the kidney and the liver, but also a severe vascular damage. Such a multiple organ disease syndrome induced by ionizing radiations was already observed in two radiation accidents, the Tokai MURA accident and the Neshvish accident. In an attempt to accelerate the hematopoietic recovery, we combined autologous cell therapy with G-CSF injections in the same model of heterogeneous irradiation with non human

  14. Assessment of radiation dose due to the accidental release of radionuclides from a DCLL reactor

    Highlights: ► Accidental release of radionuclides from a Dual-Coolant He/Pb15.7Li breeding blanket is studied. ► Activation analysis with ACAB code determines the main contributors to the environmental consequences of the accident. ► Atmospheric dispersion (in conditions D and F) is assessed with Hotspot code for the relevant radionuclides. ► The actual quantity of each radionuclide produced in 1 kg of LiPb is used in the dispersion model. ► The amount of LiPb releasable fulfilling the dose limit requirements is calculated. -- Abstract: A conceptual design for a DEMO fusion reactor based on a dual coolant He/Pb15.7Li breeding blanket (DCLL) is being developed within the Spanish Breeding Blanket Technology Programme: TECNOFUS. The production of tritium and activation products of LiPb might be a concern from the radiological safety point of view. Thus, in this contribution, an accidental release in atmosphere of radionuclides from LiPb breeder has been studied. Activation calculations have been performed with ACAB code assuming an irradiation scenario of 5 FPY for the maximum neutron fluence rate in the equatorial breeding zone. The results in terms of specific activity, surface gamma dose rate and committed effective dose (CED) due to inhalation at different times have been used to chose the potentially more hazardous radionuclides. Dispersion of the selected radionuclides has been modeled with HOTSPOT code using the Gaussian plume model and two different atmospheric conditions. Offsite dose (for external irradiation and inhalation) due to an accidental release of 1 kg of activated LiPb has been calculated after 5 FPY of irradiation (shutdown) using HOTSPOT atmospheric dispersion in class D weather conditions. According to the results, fulfilling the dose requirement for no evacuation would permit to release up to 40 kg of activated LiPb, without taking into account the possible isotopic purification and detritiation systems. This value can be compared

  15. Assessment of radiation dose due to the accidental release of radionuclides from a DCLL reactor

    Palermo, Iole, E-mail: iole.palermo@ciemat.es [CIEMAT, Avda. Complutense 40, 28040 Madrid (Spain); Gómez-Ros, J.M. [CIEMAT, Avda. Complutense 40, 28040 Madrid (Spain); Sanz, J. [Departamento de Ingeniería Energética, UNED, C/Juan del Rosal 12, 28040 Madrid (Spain); Mota, F. [CIEMAT, Avda. Complutense 40, 28040 Madrid (Spain)

    2013-10-15

    Highlights: ► Accidental release of radionuclides from a Dual-Coolant He/Pb15.7Li breeding blanket is studied. ► Activation analysis with ACAB code determines the main contributors to the environmental consequences of the accident. ► Atmospheric dispersion (in conditions D and F) is assessed with Hotspot code for the relevant radionuclides. ► The actual quantity of each radionuclide produced in 1 kg of LiPb is used in the dispersion model. ► The amount of LiPb releasable fulfilling the dose limit requirements is calculated. -- Abstract: A conceptual design for a DEMO fusion reactor based on a dual coolant He/Pb15.7Li breeding blanket (DCLL) is being developed within the Spanish Breeding Blanket Technology Programme: TECNO{sub F}US. The production of tritium and activation products of LiPb might be a concern from the radiological safety point of view. Thus, in this contribution, an accidental release in atmosphere of radionuclides from LiPb breeder has been studied. Activation calculations have been performed with ACAB code assuming an irradiation scenario of 5 FPY for the maximum neutron fluence rate in the equatorial breeding zone. The results in terms of specific activity, surface gamma dose rate and committed effective dose (CED) due to inhalation at different times have been used to chose the potentially more hazardous radionuclides. Dispersion of the selected radionuclides has been modeled with HOTSPOT code using the Gaussian plume model and two different atmospheric conditions. Offsite dose (for external irradiation and inhalation) due to an accidental release of 1 kg of activated LiPb has been calculated after 5 FPY of irradiation (shutdown) using HOTSPOT atmospheric dispersion in class D weather conditions. According to the results, fulfilling the dose requirement for no evacuation would permit to release up to 40 kg of activated LiPb, without taking into account the possible isotopic purification and detritiation systems. This value can be

  16. Evaluation of post-accidental rehabilitation strategies

    Post-accidental management aims at restoring acceptable life conditions for population on sanitary, social and economic aspects. It is then a matter for an optimisation process in a multicriteria context, which has to combine quantitative parameters as well as qualitative parameters. In order to fit with this problematic a methodological work has been realised at IPSN. The methodology consists in making a systematic evaluation of indicators in order to provide intercomparing data for many rehabilitation strategies. It relies on four steps: characterisation and formalization of the geographic and demographic environment, radiological diagnosis, selection of countermeasures from a well characterised set of techniques, and last, evaluation of the intercomparing factors. The methodology has been applied to the Becquerel national exercise. Rejects were limited and the contaminated area was less than 2000ha. Conclusions proposed depend on this context. For the selected countermeasures, radiological benefit and some incidences have been calculated: duration of realisation of the counter-measure, materials and human means, worker doses, and amount of generated wastes. In this context, calculations highlighted the importance of external exposition in built areas from the first year after the accident, for most of the reference groups. Ingestion is important only the first year for the highly autarkical level reference groups. Consequently, countermeasures applied to built areas, such as washing of sidewalks, of streets and roofs, or such as trees pruning ,are the most effective for the dosimetric criteria. In agricultural zone, taking off vegetation and ploughing enable to strongly reduce specific activity on food products. Reduction by soil removal is more effective. But here, management problems due to the large amount of generated waste could discard this kind techniques. Countermeasures on milk applied the first year reduce by 3 the dose for highly autarkical level

  17. Investigation of thermoluminescence properties of mobile phone screen displays as dosimeters for accidental dosimetry

    Mrozik, Anna; Marczewska, B.; Bilski, P.; Kłosowski, M.

    2014-11-01

    The rapid assessment of the radiation dose after unexpected exposure is a task of accidental dosimetry. In case of a radiological accident glasses originating from mobile phone screens, placed usually near the human body, could be used as emergency thermoluminescent (TL) personal dosimeters. The time between irradiation and TL readout is crucial and therefore preparation of the mobile phone screens and their readout conditions should be optimized. The influence of the samples etching, bleaching and selection of the optical filters based on measurement of the emission spectrum of irradiated glass samples during heating for different types of mobile phones were the subjects of our investigation. Obtained results showed that glasses extracted from different brands of mobile phones have different dosimetric properties but all of them give a luminescent signal which can be used to calculate the dose.

  18. Accidental releases of radionuclides: a preliminary study of the consequences of land contamination

    The long term consequences of land contamination from accidental releases of activity from thermal reactors are examined. The radiological consequences are assessed using an analysis of the exposure of individuals and the population to ground deposits of the radionuclides released. The contribution of the different nuclides in the release by their various exposure routes to the irradiation of man are calculated as a function of time after release and the most radiologically important are identified. A preliminary assessment is made of off-site economic and social consequences of accidental releases by estimating the areas of land which would be affected by the introduction of countermeasures to control individual radiation exposure due to external irradiation from ground deposits (relocation of populations), and the intake of radionuclides contained in locally produced foodstuffs (restrictions on food production). The areas where administrative controls would be necessary decline in size with time after the release; estimates are made of this time-dependent behaviour using dynamic environmental transfer models. Finally, the collective doses saved by the introduction of countermeasures are estimated using population and agricultural distribution data for a rural location in the United Kingdom. (author)

  19. Structural Integrity Assessment of VVER-1000 RPV under Accidental Cool down Transients

    Corrosion, Fatigue and Irradiation embrittlement are the major degradation mechanisms responsible for ageing of RPV (and its internals) of a Pressurized Water Reactor. While corrosion and fatigue can generate cracks, irradiation damage can lead to brittle fracture initiating from these cracks. Ageing in nuclear power plants needs to be managed so as to ensure that design functions remain available throughout the life of the plant. From safety perspective, this implies that ageing degradation of systems, structures and components important to safety remain within acceptable limits. Reactor Pressure Vessel has been identified as the highest priority key component in plant life management for Pressurized Water Reactors. Therefore special attention is required to ensure its structural integrity during its lifetime. In this paper, structural integrity assessment for typical VVER-1000 RPV is carried out under severe accidental cool down transients using the Finite Element Method. Three different accidental scenarios are postulated and safety of the vessel is conservatively assessed under these transients using the Linear Elastic Fracture Mechanics approach. Transient thermo mechanical stress analysis of the core belt region of the RPV is carried out in presence of postulated cracks and stress intensity factors are calculated and compared with the material fracture toughness to assess the structural integrity of the vessel. The paper also include some parametric analyses to justify the methodology. (author)

  20. Static and mobile networks design for atmospheric accidental releases monitoring

    The global context of my PhD thesis work is the optimization of air pollution monitoring networks, but more specifically it concerns the monitoring of accidental releases of radionuclides in air. The optimization problem of air quality measuring networks has been addresses in the literature. However, it has not been addresses in the context of surveillance of accidental atmospheric releases. The first part of my thesis addresses the optimization of a permanent network of monitoring of radioactive aerosols in the air, covering France. The second part concerns the problem of targeting of observations in case of an accidental release of radionuclides from a nuclear plant. (author)

  1. El accidente de trabajo. Concepto legal y jurisprudencia

    García Romero, José Daniel

    2015-01-01

    El trabajo final de grado versa sobre el concepto de accidente de trabajo que da la jurisprudencia a través de las diferentes sentencias del Tribunal Supremo en la Sala de lo Social, y de los diferentes Tribunales Superiores de Justicia. Analizaremos en profundidad que características tienen que concurrir para que sea considerado como tal, analizando los diferentes supuestos de accidente de trabajo como el accidente in itinere, en misión, etc. También hemos tratado las diferentes contingencia...

  2. Neuroglobin in the rat brain (II): co-localisation with neurotransmitters

    Hundahl, Christian Ansgar; Kelsen, Jesper; Dewilde, Sylvia;

    2008-01-01

    In an accompanying article, we found that neuroglobin (Ngb) was expressed in a few well-defined nuclei in the rat brain. Here, we show by use of immunohistochemistry and in situ hybridisation (ISH) that Ngb co-localise with several specific neurotransmitters. Ngb co-localise consistently with......-localised melanin concentration hormone (MCH). A few Ngb-ir perikarya in the paraventricular hypothalamic nucleus (PVN) co-localised arginine vasopressin (aVP). Ngb were not observed to co-localise with serotonin, vasointestinal peptide (VIP), or cocaine amphetamine-regulated transcript (CART) at any places. In the...

  3. Miasis genital accidental por Eristalis tenax Accidental genital myiasis by Eristalis tenax

    Mauricio González M; Greissy Comte M; Javiera Monárdez P; Marcelo Díaz de Valdés L; Iván Matamala C

    2009-01-01

    Las miasis son infestaciones parasitarias de humanos o animales por larvas de mosca que infestan piel, tejidos necróticos y cavidades naturales. Presentamos el caso de una mujer de 27 años, asintomática, que eliminó espontáneamente por vía vaginal larvas de Eristalis tenax, una especie de mosca ampliamente distribuida en el mundo, la que es clasificada como agente de miasis accidental. La paciente residía en un área urbana de nivel socioeconómico bajo y entregaba como antecedente el uso de ve...

  4. Cytogenetic biological dosimetry. Dose estimative in accidental exposure

    The methodology of cytogenetic biological dosimetry is studied. The application in estimation of dose in five cases of accidental exposure is reported. An hematological study and culture of lymphocytes is presented. (M.A.C.)

  5. Localisation of directional scale-discretised wavelets on the sphere

    McEwen, Jason D; Wiaux, Yves

    2015-01-01

    Scale-discretised wavelets yield a directional wavelet framework on the sphere where a signal can be probed not only in scale and position but also in orientation. Furthermore, a signal can be synthesised from its wavelet coefficients exactly, in theory and practice (to machine precision). Scale-discretised wavelets are closely related to spherical needlets (both were developed independently at about the same time) but relax the axisymmetric property of needlets so that directional signal content can be probed. Needlets have been shown to satisfy important quasi-exponential localisation and asymptotic uncorrelation properties. We show that these properties also hold for directional scale-discretised wavelets on the sphere and derive similar localisation and uncorrelation bounds in both the scalar and spin settings. Scale-discretised wavelets can thus be considered as directional needlets.

  6. [Frequency and most common localisation of root canal curvature].

    Blasković-Subat, V

    1991-01-01

    The root canal therapy of the curved canals is a complex operative procedure. Therefore 260 root canals were analysed radiologically to determine the frequency and the most common localisation of the root canal curvature. The frequency of the curved canals averaged at 59%, being greater in the sample of posterior than in the anterior teeth (p less than 0.05). The root canal curvature was most frequently localised at the apical third part (53.9%), followed by the cervical (33.3%) and the middle (12.8%) third part. The apical curvature was predominant in the sample of the anterior, while the cervical predominant (45.2%) in the sample of the posterior teeth. This study pointed out that the frequency of the curved canals is rather high. Consequently, the necessity for practising the modern root canal preparation techniques, bearing in mind their potential danger, is emphasized. PMID:1819932

  7. Localised plasma density enhancements around comet CG/67P

    Henri, Pierre; Broiles, Tom; Eriksson, Anders; Béghin, Christian; Lebreton, Jean-Pierre; Vallieres, Xavier; More, Jerome; Wattieaux, Gaetan; Engelhardt, Ilka A. D.; Edberg, Niklas; Odelstad, Elias; Vigren, Erik; Glassmeier, Karl-Heinz; Goetz, Charlotte; Koenders, Christoph; Richter, Ingo; Volwerk, Martin; Burch, James L.; Goldstein, Ray; Mandt, Kathleen

    2016-04-01

    Comet 67P/Churyumov-Gerasimenko, target of the ESA's Rosetta mission, reached its perihelion at 1.3 AU from the Sun in August 2015. Its plasma environment will go on being monitored by the Rosetta Plasma Consortium (RPC) as the distance to the sun increases, until end of mission in September 2016. Combining observations from the different RPC sensors, we investigate localised, strong enhancements of the cometary plasma density over short timescales (~ minutes to seconds) observed during the period April 2015 - January 2016. These strong plasma density variations (RPC-MIP and RPC-LAP) are likely associated to cold electrons (RPC-IES) and generally observed during magnetic field rotations (RPC-MAG). The location of such events, both in the rotating comet frame and with regard to the magnetic field direction, is discussed to better constrain the mechanism at the origin of these localised plasma density enhancements.

  8. Bremstrahlung Detection and Chamber Obstruction Localisation Using Scanning Radiation Detectors

    Naylor, G A; Robinson, D

    2005-01-01

    Radiation monitors consisting of scintillating plastic coupled to photomultipliers are used for diagnostic purposes. By scanning such a detector or a radiation scatterer, two applications are demonstrated: i) Monitoring of vacuum chamber conditioning by monitoring gas Bremstrahlung from residual gas. ii) Localisation of beam interception (beam losses) by longitudinal scanning of a radiation detector. The measurement of gas pressure inside long, small cross section, vacuum vessels is difficult due to the distance between the centre of the vacuum vessel and vacuum gauges (leading to a low vacuum conductance). The narrow beam of gamma Bremstrahlung radiation is intercepted by scanning tungsten blades in the beam line front-end allowing a radiation shower to be detected outside the vacuum vessel proportional to the gas pressure in the corresponding storage ring straight section. A second detector mounted on rails can be moved over a length of 6.5m parallel to the ESRF storage ring so as to localise regions of bea...

  9. Mistakes in diagnosing non-accidental injury: 10 years' experience

    Wheeler, David M; Hobbs, Christopher J

    1988-01-01

    Fifty children who were referred to the child abuse team in Leeds over the 10 years 1976-86 with suspected non-accidental injury were found to have conditions which mimicked non-accidental injury. These included impetigo (nine children) and blue spots (five children). Five children who presented with multiple bruising had haemostatic disorders. Eight children had disorders of the bone. Five children had been previously abused physically. Four showed evidence of neglect. One had evidence of no...

  10. Accidental Implant Screwdriver Ingestion: A Rare Complication during Implant Placement.

    Anshul Jain; Baliga, Shridhar D

    2014-01-01

    One of the complications during a routine dental implant placement is accidental ingestion of the implant instruments, which can happen when proper precautions are not taken. Appropriate radiographs should be taken to locate the correct position of foreign body; usually the foreign body passes asymptomatically from gastrointestinal tract but sometimes it may lead to intestinal obstruction, perforations and impactions. The aim of this article is to report accidental ingestion of 19 mm long scr...

  11. Limitations in localising and killing tumours using radiolabelled antibodies

    Radiolabelled antibodies against tumours are being studied intensely for their use in tumour detection and tumour destruction. Although a host of different tumour types can be localised, results at present are no better than other scanning techniques. In addition no tumour has been eradicated using labelled antibodies. Dramatic improvements will depend upon a fuller understanding of tumour cell biology and optimising all the parameters involved. (orig.)

  12. Simultaneous Mapping and Localisation for Small Military Unmanned Underwater Vehicle

    Arom Hwang; Woojae Seong

    2012-01-01

    Paper proposes a simultaneous localisation and mapping (SLAM) scheme which is applicable to small military unmanned underwater vehicles (UUVs). The SLAM is a process which enables concurrent estimation of the position of UUV and landmarks in the environment through which the vehicle is passing. An unscented Kalman filter (UKF) is utilised to develop a SLAM suitable to nonlinear motion of UUV. A range sonar is used as a sensor to collect the relative position information of the landmark in the...

  13. APPLYING INNOVATIVE METHODOLOGICAL MODELS IN THE LITERARY TEXT LOCALISATION

    Franciskovic, Dragana

    2012-01-01

    The paper deals with the research aimed at evaluating the possibilities and the level of influence of modern teaching methods on the quality of literary text analysis. Modern teaching methods certainly have a certain influence on student's literary experience and ability to analyse literary works. We have researched the aforementioned level of influence within the specific educational sphere using literary excerpts in the phase of text localisation. The research presents the results of parall...

  14. Automated quantum conductance calculations using maximally-localised Wannier functions

    Shelley, Matthew; Poilvert, Nicolas; Mostofi, Arash A.; Marzari, Nicola

    2011-01-01

    A robust, user-friendly, and automated method to determine quantum conductance in disordered quasi-one-dimensional systems is presented. The scheme relies upon an initial density- functional theory calculation in a specific geometry after which the ground-state eigenfunctions are transformed to a maximally-localised Wannier function (MLWF) basis. In this basis, our novel algorithms manipulate and partition the Hamiltonian for the calculation of coherent electronic transport properties within ...

  15. The case for localised energy management to support resilient cities

    Rodrigues, Lucélia Taranto; Marsh, Julian; Kiamba, Lorna; Gillott, Mark C.; O'Doherty, Travis

    2016-01-01

    Localised energy generation, ownership and management provide a mechanism to address issues of affordability, energy security, infrastructure resilience and the need to reduce greenhouse gases emissions. There is potential for the growth of community energy schemes in the UK. However, small to medium-sized schemes find it hard to compete with large energy providers. Energy Service Companies (ESCOs) are created to manage the local production and distribution of energy. In Nottingham, the Meado...

  16. A Framework for Designing Usable Localised Business Websites

    Ali H. Al-Badi; Pam J. Mayhew

    2010-01-01

    Website localisation is the process of adapting the linguistic and cultural content of an internationalised web design for a specific target audience in a specific locale. With the advent of globalisation, website l ocalisation is becoming a powerful way to attract online customers in a global market. Hence, the main driving force behind such moves is financial, but with a strong motivation towards cross-cultural sensitivity. The primary aim of this research therefore is to explore the desig...

  17. Experimental determination of critical exponents in Anderson localisation of light

    Aegerter, Christof M.; Störzer, Martin; Maret, Georg

    2006-01-01

    Anderson localisation predicts a phase transition in transport, where the diffuse spread of particles comes to a halt with the introduction of a critical amount of disorder. This is due to constructive interference on closed multiple scattering loops which leads to a renormalisation of the diffusion coefficient. This can be described by a slowing-down of diffusion, where the diffusion coefficient decreases with time according to a power law with an exponent a. In the case of strong localisati...

  18. Diagnostic approach to localised organising pneumonia: A case report

    Đurić Mirna; Považan Đorđe; Đurić Dejan; Eri Živka; Trudić Anika

    2015-01-01

    Introduction. Localised organising pneumonia, radiologically presented with oval or round shadows mimicing lung cancer or metastases, is a major issue in differential diagnosis. Case report. A female patient was hospitalized to clarified the etiology of multiple nodular lung lesions. The chest X-ray and the chest computed tomography (CT) revealed bilateral patchy and nodular shadows, and round lung lesions, respectively. Neither sputum analyses, nor histolo...

  19. Lessons learned from accidental exposures in radiotherapy

    The medical use of radiation is unique in that patients are intentionally exposed to radiation. The aim in radiation therapy is twofold: to deliver a dose and dose distribution that is adequate for tumour control, but which also minimizes complications in normal tissues. In therapeutic applications, the doses are high and a deviation from the prescribed dose may have severe or even fatal consequences. There is therefore a great need to ensure adequate radiation protection and safety in radiotherapy by verifying that all personnel involved are appropriately trained for their duties, that the equipment used meets relevant international specifications for radiation safety and that safety culture is embedded in routine activities in radiotherapy departments. Many individuals must interact and work together on highly technical measurements and calculations, and therefore the potential for mistakes is great. A review of the mistakes shows that most are due to human error. The International Basic Safety Standards for Protection against Ionizing Radiation and the Safety of Radiation Sources (IAEA Safety Series No. 115) require that a prompt investigation be conducted whenever an accidental medical exposure of patients occurs. The report of the investigation is to be disseminated to the appropriate parties so that lessons can be learned to prevent similar accidents or mitigate their consequences in the future. This Safety Report is a collection of a large number of events that may serve as a checklist against which to test the vulnerability of a facility to potential accidents, and to provide a basis for improving safety in the use of radiation in medical applications. A further purpose of this report is to encourage readers to develop a questioning and learning attitude, adopt measures for the prevention of accidents, and prepare for mitigation of the consequences of accidents if they occur

  20. Accidental oil spills - project management strategy

    Planning and organisation, as well as actions taken during accidental discharging of hazardous substances (hydrocarbons) into the soil and water, show that without integrating all the functions of safety, occupational safety, fire and explosion protection, technical safety, all the way to the environmental protection, procedure of cleaning, rehabilitation and remediation of polluted areas into their original state cannot be successfully carried out. Neglecting any of the mentioned links/components of the procedure represents a risk to people's health and life, while pollution to the environment remains a constant threat. Development of technologies is quickly transforming the environment in which the professionals of all disciplines work. Therefore, the response to changes by application of new technologies and procedures in all domains is indispensable, however, through a comprehensive and expert perception and consideration of each of the essential correlations comprising the safety management in all the fields. Through management of safety projects in environmental protection, it has become obvious that a united management of different fields is necessary, as well as management of safety in general. Engineering, health, legislation, public, environmental standards, occupational safety, hazards, biophysical and socio-economic aspects are parts of an integral management. Experts joined efforts through interaction and communications are inter-disciplinary characteristics, i.e. multi-disciplinary safety management, but also the management of each project separately. Exactly this knowledge exchange is highly productive and becomes an indispensable element in recognition of indirect and cumulative actions, thus applicable in any field. Implementation of European standards and accreditation of procedures pursuant to the corresponding standards, from risk assessment through rehabilitation to independent expert confirmation of efficiency in implementing the entire

  1. Strain localisation in mechanically Layered Rocks, insights from numerical modelling

    L. Le Pourhiet

    2012-09-01

    Full Text Available Small scale deformation in stratified rocks displays a large diversity of micro-structures, from the microscopic scale to the scale of orogens. We have designed a series of fully dynamic numerical simulations aimed at assessing which parameters control this structural diversity and which underlying mechanisms lead to strain localisation. The influence of stratification orientation on the occurrence and mode of strain localisation is tested by varying the initial dip of inherited layering versus the large scale imposed simple shear. The detailed study of the models indicates that (1 the results are length-scale independent, (2 the new shear zones are always compatible with the kinematics imposed at the boundary (3 micro-structures formed encompass the full diversity of micro-structures observed in the field and chiefly depend on the direction of the initial anisotropy versus shear direction, (4 depending on the orientation of the anisotropy, the layers may deform along subtractive or additive shear bands, (5 the deformation in anisotropic media results in non-lithostatic pressure values that are on the order of the deviatoric stress in the strong layers and (6 the introduction of brittle rheology is necessary to form localised shear bands in the ductile regime.

  2. Weak localisation in high quality two dimensional systems

    Full text: The quantum properties of two dimensional (2D) electronic devices are of great interest both scientifically and, increasingly, technologically. The time scale over which quantum effects operate in these systems is limited by the phase breaking time τφ. Study of the weak localisation effect (the increase in electrical resistance due to phase coherent backscattering) can enable τφ to be quantified. We investigate phase coherent weak localisation effects in high quality 2D electron and hole systems, and show how the values of phase coherence time extracted from the raw data depend critically on which of the methods selected from the literature is used to fit the weak localisation correction to the magneto-conductivity. We compare four different methods available in the literature and discuss the differences and relative merits of each. All four methods are then used to fit magneto-conductivity data from high quality 2D GaAs hole systems over a range of carrier densities and temperatures. We compare the extracted phase coherence time, τφ, to the phase breaking rate expected from Fermi liquid theory and show that the method of Dimitriev et al. - the most sophisticated method, used for the first time here - is in good quantitative agreement with Fermi liquid theory despite the presence of strong hole-hole interactions, rs ∼ 20

  3. Diagnostic approach to localised organising pneumonia: A case report

    Đurić Mirna

    2015-01-01

    Full Text Available Introduction. Localised organising pneumonia, radiologically presented with oval or round shadows mimicing lung cancer or metastases, is a major issue in differential diagnosis. Case report. A female patient was hospitalized to clarified the etiology of multiple nodular lung lesions. The chest X-ray and the chest computed tomography (CT revealed bilateral patchy and nodular shadows, and round lung lesions, respectively. Neither sputum analyses, nor histology of bronchoscopy samples clarified the etiology of these lung lesions. As secondary deposits in the lungs were suspected, video-assisted thoracoscopy and anterolateral right minithoracotomy with atypical upper and lower lobe resection were performed. The frozen-section analysis suggested the benign nature of the lesion, and the definite histopathological finding of localised organising pneumonia was established. Due to bilateral lung lesions, corticosteroids were applied. Seven weeks later, the chest CT finding revealed a total regression of the lesions. Conclusion. A surgical resection was necessary to diagnose the localised organising pneumonia which mimiced secondary malignant lesions, thus establishing the definite etiology of lung lesions. Bronchoscopic cryobiopsy, recently introduced in order to obtain peripheral lung biopsy samples, has provided new possibilities in the diagnosis and treatment of neoplastic and non-neoplastic lung diseases.

  4. Evolution of glycaemia during irradiation syndrome

    The evolution of glycaemia following irradiation has been followed in the rat and pig. The results concerning a case of human accidental exposure have also been included. The author has tried to see whether the observed variations are reproducible and have a prognostic value. (author)

  5. Strain weakening and localisation: material properties or boundary effects?

    Ritter, Malte C.; Leever, Karen; Rosenau, Matthias; Oncken, Onno

    2015-04-01

    Strain weakening is commonly seen as one of the major causes of localisation of deformation into shear zones in brittle media. Several studies, both numerical and physical experiments, investigate its influence. Typically, these studies choose a certain model configuration and test various material properties and their influence on localisation in that particular configuration. This approach, however, does not take into account the fundamental importance of boundary conditions on the processes of localisation, weakening and overall shear zone evolution. To address this issue, we perform physical experiments in granular materials. We create shear fractures within a sample of granular material (sand) using different experimental apparatuses that apply different boundary conditions. Among them are standard machines such as a Ring-Shear Tester and the classical Riedel set up, as well as a newly designed set up. Boundary conditions can be varied from purely kinematic to more dynamically controlled and from laterally confined to unconfined. Nevertheless, the final result of deformation is an approximately straight strike-slip shear zone in all cases. We monitor boundary force (i. e. material strength) and, where experimentally accessible, strain, at high temporal resolution during deformation. With our different set ups we are able to produce very different patterns of deformation and weakening in the same material under the same constant rate of shearing and with the same final result. Observed patterns span from nearly instantaneous formation of one single through-going shear zone to slow, step-wise growth of a complex network of interacting cracks. Weakening in all cases matches well the structural evolution. Variations of weakening for a given material in different set ups are larger than for different materials in a given set up. Our results show that for a given material the style and rate of localisation can change drastically, depending on only slight changes of

  6. [Severe accidental hypothermia in an elderly woman].

    Knobel, B; Mikhlin, A

    2001-11-01

    Profound hypothermia (core temperature of less than 28 degrees C) is a life threatening state and a medical emergency associated with a high mortality rate. The prognosis depends on underlying diseases, advanced or very early age, the duration prior to treatment, the degree of hemodynamic deterioration, and especially, the methods of treatment, including active external or internal rewarming. This is a case study of an 80-year-old female patient with severe accidental hypothermia (core temperature 27 degrees C). She was found in her home lying immobile on the cold floor after a fall. The patient was in a profound coma with cardiocirculatory collapse, and the medical staff treating her was inclined to pronounce her deceased. On her arrival at the hospital, she was resuscitated, put on a respirator and actively warmed. Very severe metabolic disorders were found, including a marked metabolic acidosis composed of diabetic ketoacidosis (she had suffered from insulin treated type 2 diabetes mellitus) and lactic acidosis with a very high anion gap (42) and a hyperosmotic state (blood glucose 1202 mg/dl). There were pathognomonic electrocardiographic abnormalities, J-wave of Osborn and prolonged repolarization. Slow atrial fibrillation with a ventricular response of 30 bpm followed by a nodal rhythm of 12 bpm and reversible cardiac arrest were recorded. The pulse and blood pressure were unobtainable. Despite the successful resuscitation and hemodynamic and cognitive improvement, rhabdomyolysis (CKP 6580 u/L), renal failure and hepatic damage developed. She was extubated and treated with intravenous fluids containing dopamine, bicarbonate, insulin and antibiotics. Her medical condition gradually improved, and she was discharged clear minded, functioning very well and independent. Renal and liver tests returned eventually to normal limits. Progressive bradycardia, hypotension and death due to ventricular fibrillation or asystole commonly occur during severe hypothermia

  7. Accidental exposition with xray diffraction equipment

    The plug fault Xray diffraction equipment promoted searcher irradiation.The film dosemeter who he carried was over exposed (D.O.>4.5). The reconstruction of the accident for value the operator dose received and future effects of him. The troubled received the following dose: 350-700 rad in 1 to 2 minutes in thorax and probably face level,this one measured with X ray chamber as low energy. The involved tissue were: skin, thyroids and crystalline of the eye. As conclusion a partial dose received for the worker had not threshold value for produce deterministic effects

  8. Causes of accidental childhood deaths in China in 2010

    Chan, Kit Yee; Yu, Xin-Wei; Lu, Jia-Peng;

    2015-01-01

    middle-income country (LMIC) settings. In this paper, we aim to establish cause structure for accidental deaths in children aged 0-4 years in China in the year 2010. METHODS: In this paper, we explored the database of 208 multi-cause child mortality studies in Chinese that formed a basis for the first...... deaths. We identified 71 further studies that provided specific causes for accidental deaths. We used epidemiological modeling to estimate the number of accidental child deaths in China in 2010 and to assign those deaths to specific causes. RESULTS: In 2010, we estimated 314 581 deaths in children 0......-4 years in China, of which 31 633 (10.1%) were accidental. Accidental deaths contributed 7240 (4.0%) of all deaths in neonatal period, 8838 (10.5%) among all post-neonatal infant deaths, and 15 554 (31.7%) among children with 1-4 years of age. Among four tested models, the most predictive was used to...

  9. Cost of accidental carbon monoxide poisoning: A preventable expense.

    Hampson, Neil B

    2016-06-01

    Carbon monoxide (CO) poisoning is common in the United States, accounting for hundreds of deaths and thousands of emergency department visits annually. It is believed that most accidental CO poisoning is preventable through public education, warning labels on consumer products, and uniform use of residential CO alarms. However, cost effectiveness of these prevention strategies has not been demonstrated in the United States to date. It was the objective of this study to estimate societal cost of accidental CO poisoning and evaluate the cost-effectiveness of universal installation of residential CO alarms. Published studies and data from the English language literature were used in to estimate direct hospital costs and lost earnings resulting from accidental CO poisoning. The study was performed in the US in 2015. Approximately 6600 individuals are estimated to sustain long-term cognitive sequela annually, with total loss in earnings of approximately $925 million, 334 individuals die from accidental, non-fire related CO poisoning with an average loss of 26 years of productivity accounting for $355 million, and 2800 are hospitalized with acute medical care costs of $33 million. Available data indicate that accidental CO poisoning in the US conservatively costs society over $1.3 billion, resulting from direct hospital costs and lost earnings. Further, it demonstrates a positive cost-benefit ratio for the uniform use of residential CO alarms. PMID:26844181

  10. Orthogonal views improves localisation in bone scans of wrist

    Roth, A.L.

    1997-09-01

    Full text: Of all nuclear medicine studies, bone scans are the most fundamental. However, straightforward these may seem, there are always mechanisms that can be implemented which assist in a more precise diagnosis, particularly in areas with an intricate bone structure. An 18-year-old right-handed student presented to her doctor with a one month history of pain over the right distal radio-ulna joint area. Clinically, she had prominence of the right ulna, which suggested that there may have been a previous injury to the wrist. Also, pronation/supination were painful where there was swelling of the extensor carpi ulnaris tendon, as well as some discomfort with clicking in ulna deviation/rotation. The X-rays demonstrated some premature radial epiphysial closure. A bone scan was requested to attempt to localise the main inflammatory focus. The dynamic study was performed in the planar projection with an immediate blood pool for 300k being taken. These demonstrated a vascular blush medially. A medial blood pool image was acquired and it localised the abnormal vascularity as being dorsal. A separate focal area of less intense blood pooling was also noted in the line of the distal ulna. Delayed images showed increased uptake localised to the ulna styloid. Anatomically, the superficial vascular blush correlated with tenosynovitis. Hence, the orthogonal initial and delayed images were definitive in the diagnoses of tenosynovitis of the extensor carpi ulnaris tendon. This clearly complements the information provided by the palmar view. However, it is important to remember that an increased radiation dose to the technologist is incurred as a result of the extra orthogonal view, hence attention to technique is imperative.

  11. Orthogonal views improves localisation in bone scans of wrist

    Full text: Of all nuclear medicine studies, bone scans are the most fundamental. However, straightforward these may seem, there are always mechanisms that can be implemented which assist in a more precise diagnosis, particularly in areas with an intricate bone structure. An 18-year-old right-handed student presented to her doctor with a one month history of pain over the right distal radio-ulna joint area. Clinically, she had prominence of the right ulna, which suggested that there may have been a previous injury to the wrist. Also, pronation/supination were painful where there was swelling of the extensor carpi ulnaris tendon, as well as some discomfort with clicking in ulna deviation/rotation. The X-rays demonstrated some premature radial epiphysial closure. A bone scan was requested to attempt to localise the main inflammatory focus. The dynamic study was performed in the planar projection with an immediate blood pool for 300k being taken. These demonstrated a vascular blush medially. A medial blood pool image was acquired and it localised the abnormal vascularity as being dorsal. A separate focal area of less intense blood pooling was also noted in the line of the distal ulna. Delayed images showed increased uptake localised to the ulna styloid. Anatomically, the superficial vascular blush correlated with tenosynovitis. Hence, the orthogonal initial and delayed images were definitive in the diagnoses of tenosynovitis of the extensor carpi ulnaris tendon. This clearly complements the information provided by the palmar view. However, it is important to remember that an increased radiation dose to the technologist is incurred as a result of the extra orthogonal view, hence attention to technique is imperative

  12. Nerve growth factor levels and localisation in human asthmatic bronchi.

    Olgart Höglund, C; de Blay, F; Oster, J P; Duvernelle, C; Kassel, O; Pauli, G; Frossard, N

    2002-11-01

    Nerve growth factor (NGF) has recently been suggested to be an important mediator of inflammation. In support of this, serum levels of NGF have been shown to be enhanced in asthmatics. However, it has not yet been shown whether the levels of NGF are also altered locally in asthmatic airways, when compared with healthy subjects, and the localisation of potential sources of NGF in the human bronchus have not yet been described. The aim of the present study was to assess NGF levels in bronchoalveolar lavage fluid (BALF) from asthmatics and to compare them to those of control subjects. Furthermore, the authors wanted to localise potential sources of NGF in bronchial tissue, and to number NGF-immunopositive infiltrating cells in the bronchial submucosa. BALF and bronchial biopsies were obtained from seven control subjects and seven asthmatic patients by fibreoptic bronchoscopy. NGF protein levels were quantified by enzyme-linked immunosorbent assay in BALF. NGF localisation was examined by immunohistochemistry on bronchial biopsy sections. The asthmatics exhibited significantly enhanced NGF levels in BALF. Intense NGF-immunoreactivity was observed in bronchial epithelium, smooth muscle cells and infiltrating inflammatory cells in the submucosa, and to a lesser extent in the connective tissue. The asthmatics exhibited a higher number of NGF-immunoreactive infiltrating cells in the bronchial submucosa than control subjects. This study provides evidence that nerve growth factor is locally produced in the airways, and shows that this production is enhanced in asthmatics. These findings suggest that nerve growth factor is produced by both structural cells and infiltrating inflammatory cells in human bronchus in vivo, and the authors suggest that the increase in nerve growth factor protein in bronchoalveolar lavage fluid observed in asthmatic patients may originate both from structural cells, producing increased nerve growth factor levels in inflammatory conditons, and from

  13. Simultaneous Localisation and Mapping Using a Single Camera

    Williams, Brian P.; Reid, Ian D.

    2009-01-01

    This thesis describes a system which is able to track the pose of a hand-held camera as it moves around a scene. The system builds a 3D map of point landmarks in the world while tracking the pose of the camera relative to this map using a process called simultaneous localisation and mapping (SLAM). To achieve real-time performance, the map must be kept sparse, but rather than observing only the mapped landmarks like previous systems, observations are made of features across the entire image. ...

  14. SLAM contraint pour la localisation dans des environnements partiellement connus

    Naudet, Sylvie; Gay-Bellile, Vincent; Bourgeois, Steve; Tamaazousti, Mohamed; Larnaout, Dorra; Dhome, Michel

    2014-01-01

    National audience Cet article porte sur la localisation temps réel d'une caméra mobile dans un environnement partiellement connu. Ces travaux reposent sur une solution de type SLAM monoculaire et traitent la problématique de dérive inhérente à ce type de méthode en proposant un nouvel ajustement de faisceaux, dit ajustement de faisceaux contraint. Ce dernier permet d'intégrer des contraintes géométriques apportées par le modèle partiellement connu de la scène. Nous montrons l'apport de cet...

  15. The application of nuclear localisation technologies in environmental biology

    Nuclear and related localisation technologies at ANSTO have been applied to a range biological matrices, in relation to specific environmental questions. Several of these applications are summarised, including the localization of lead and other elements in crocodile osteoderms and validation of bivalve shell micro-laminations as archival monitors of pollution signals. The co-location of Ca and its metabolic analogue Ra-226 led to further development of a theoretical model of bioaccumulation of alkaline-earth and other elements in the tissue of Australian freshwater bivalves under natural conditions, which were not appreciably altered by uranium mining in the region

  16. Spatially Adaptive Density Estimation by Localised Haar Projections

    Gach, Florian; Spokoiny, Vladimir

    2011-01-01

    Given a random sample from some unknown density $f_0: \\mathbb R \\to [0, \\infty)$ we devise Haar wavelet estimators for $f_0$ with variable resolution levels constructed from localised test procedures (as in Lepski, Mammen, and Spokoiny (1997, Ann. Statist.)). We show that these estimators adapt to spatially heterogeneous smoothness of $f_0$, simultaneously for every point $x$ in a fixed interval, in sup-norm loss. The thresholding constants involved in the test procedures can be chosen in practice under the idealised assumption that the true density is locally constant in a neighborhood of the point $x$ of estimation, and an information theoretic justification of this practice is given.

  17. Suppressing proton decay in theories with localised fermions

    We calculate the contribution to the proton decay amplitude from Kaluza-Klein lepto-quarks in theories with extra dimensions, localised fermions and gauge fields which propagate in the bulk. Such models naturally occur within the context of M theory. In SU(5) models we show that carefully including all such modes gives a distinctive pattern of decays through various channels including a strong suppression of decays into neutrinos or right handed positrons. By contrast there is no such suppression for SO(10). (author)

  18. Active surveillance strategy for patients with localised prostate cancer

    Thomsen, Frederik Birkebæk

    2014-01-01

    BACKGROUND: Active surveillance - an initial observational strategy - offers a tailored management of patients with localised prostate cancer. The aim of the strategy is to appoint patients with potentially lethal prostate cancer to curatively intended treatment, while patients with slowly evolving...... criteria in the management of prostate cancer patients on active surveillance is emphasised....... measurements, repeated biopsies, and regular digital rectal examinations. The programme recommended change of management from active surveillance to curatively intended treatment based on PSA doubling time, deteriorating histopathology in repeated prostatic biopsies, and increased clinical tumour category...

  19. Localised wedge shaped defects of the retinal nerve fibre layer in glaucoma.

    Jonas, J. B.; Schiro, D

    1994-01-01

    Glaucoma can be associated with a diffuse or localised loss of the retinal nerve fibre layer (RNFL). This study evaluated the wedge shaped localised RNFL defects. Red free wide angle RNFL photographs of 421 patients with glaucoma and 193 normal subjects were examined. Localised RNFL defects were described for one eye of the normal group and for 20% of the patients with glaucoma. They were usually located in the inferior temporal and superior temporal fundus regions. Within the glaucoma group,...

  20. Making Sense of Localisation in China - Voices from A German multinational in Shanghai

    Siegrist, Katharina Cornelia

    2010-01-01

    In a globalising world economy the issue of localisation among foreign invested enterprises in China has been a hot topic throughout the last years. Not only in terms of sourcing and procurement, or more and more relocations of manufacturing or R&D to China localisation was discussed and supported by the Chinese government (e.g. subsidies for foreign firms investing in research laboratories in China), but also in terms of HR work and localisation of management positions. With huge numbers of ...

  1. Correcting for accidental correlations in saturated avalanche photodiodes

    Grieve, James A; Tang, Zhongkan; Ling, Alexander

    2015-01-01

    In this paper we present a high-level numerical model for estimating rates of accidental correlations between a pair of passively quenched Geiger mode avalanche photodiodes operating in the saturated regime. By considering the recovery time of both the diodes and the detection circuit we introduce the concept of an "effective duty cycle" and show that it may be estimated by numeric simulation. The impact of effective duty cycle on the observed accidental rate is examined and we demonstrate that the updated model leads to an improved correction factor in actual experiments. This will improve the signal-to-noise ratio in applications depending on correlation measurements.

  2. Accidental ingestion of a fractured Twin-block appliance.

    Rohida, Neeraj S; Bhad, Wasundhara A

    2011-01-01

    Orthodontic appliances that become dislodged can cause problems in the airway or the gastrointestinal tract. Accidental ingestion of an appliance during a chair-side procedure or because of inadequate retention of the appliance can create a medical emergency with potentially serious complications, including death from aspiration of the foreign body. This article reports the accidental ingestion of a fractured Twin-block appliance. The ease with which removable appliances can become dislodged if retention is inadequate is discussed, and some serious complications that can arise are described. Precautions the orthodontist can take to prevent such accidents are presented. PMID:21195285

  3. Pattern Formation on Networks: from Localised Activity to Turing Patterns.

    McCullen, Nick; Wagenknecht, Thomas

    2016-01-01

    Networks of interactions between competing species are used to model many complex systems, such as in genetics, evolutionary biology or sociology and knowledge of the patterns of activity they can exhibit is important for understanding their behaviour. The emergence of patterns on complex networks with reaction-diffusion dynamics is studied here, where node dynamics interact via diffusion via the network edges. Through the application of a generalisation of dynamical systems analysis this work reveals a fundamental connection between small-scale modes of activity on networks and localised pattern formation seen throughout science, such as solitons, breathers and localised buckling. The connection between solutions with a single and small numbers of activated nodes and the fully developed system-scale patterns are investigated computationally using numerical continuation methods. These techniques are also used to help reveal a much larger portion of of the full number of solutions that exist in the system at different parameter values. The importance of network structure is also highlighted, with a key role being played by nodes with a certain so-called optimal degree, on which the interaction between the reaction kinetics and the network structure organise the behaviour of the system. PMID:27273339

  4. Localising fast radio bursts and other transients using interferometric arrays

    Obrocka, Monika; Wilkinson, Peter

    2015-01-01

    A new population of sources emitting fast and bright transient radio bursts has recently been identified. The observed large dispersion measure values of FRBs suggests an extragalactic origin and an accurate determination of their positions and distances will provide an unique opportunity to study the magneto-ionic properties of the IGM. So far, FRBs have all been found using large dishes equipped with multi-pixel arrays. While large single dishes are well-suited for the discovery of transient sources they are poor at providing accurate localisations. A 2D snapshot image of the sky, made with a correlation interferometer array, can provide an accurate localisation of many compact radio sources simultaneously. However, the required time resolution to detect FRBs and a desire to detect them in real time, makes this currently impractical. In a beamforming approach, where many narrow tied-array beams are produced, the advantages of single dishes and interferometers can be combined. We present a proof-of-concept a...

  5. Pattern Formation on Networks: from Localised Activity to Turing Patterns

    McCullen, Nick; Wagenknecht, Thomas

    2016-06-01

    Networks of interactions between competing species are used to model many complex systems, such as in genetics, evolutionary biology or sociology and knowledge of the patterns of activity they can exhibit is important for understanding their behaviour. The emergence of patterns on complex networks with reaction-diffusion dynamics is studied here, where node dynamics interact via diffusion via the network edges. Through the application of a generalisation of dynamical systems analysis this work reveals a fundamental connection between small-scale modes of activity on networks and localised pattern formation seen throughout science, such as solitons, breathers and localised buckling. The connection between solutions with a single and small numbers of activated nodes and the fully developed system-scale patterns are investigated computationally using numerical continuation methods. These techniques are also used to help reveal a much larger portion of of the full number of solutions that exist in the system at different parameter values. The importance of network structure is also highlighted, with a key role being played by nodes with a certain so-called optimal degree, on which the interaction between the reaction kinetics and the network structure organise the behaviour of the system.

  6. Demonstration of the astral post accidental code

    . The results proposed by ASTRAL can in turn be saved in its database, on the user's request, in order to be processed by other tools such as Geographical Information Systems, which enable spatial analysis and map production. Such maps are very helpful in crisis situations to decision makers since by answering to questions of a 'where?' type, at a given time, they complete the information delivered by ASTRAL, which answers to questions of a 'when?' type, at a given site. This is why a link to ASTRAL has been constructed in CARTINFO, an IRSN tool dedicated to mapping results for its Crisis Technical Center. Thus the CONRAD, ASTRAL and CARTINFO softwares constitute a chain for IRSN's Crisis Technical Center, calculating transfers through the environment and consequences of an atmospheric accidental radionuclide release. The development of this version started in 1999 and has been subject to a quality assurance program. The identified customers and users have been associated in a control committee expressing needs, validating choices and checking the good progress of the project. The programming is currently being validated by test scenarios that check the equations, parameters, functionalities and navigation through the screens. The technology and architecture chosen for the second version of ASTRAL are different from the previous ones. It now uses an internet technology and is of a three-third type, the software requiring an Oracle database, a Microsoft web server and a consultation station. These choices offer important advantages: the spreading and maintenance of the tool are very easy. In fact, once the server and the database have been installed an a network, the users only need a web browser to run the code. The initial installation and the updating are thus no more to be made an every user station, but only on the server and/or the database; the code may be installed on a portable computer, which hosts the database, the internet server and the web browser. This

  7. Accidental neutron dosimetry with human hair

    Human hair contains sulfur, which can be activated by fast neutrons. The 32S(n,p)32P reaction with a threshold of 2.5 MeV was used for fast neutron dose estimation. It is a very important parameter for individual dose reconstruction with regards to the heterogeneity of the neutron transfer to the human body. Samples of human hair were irradiated in a radial channel of a training reactor VR-1. 32P activity in hair was measured both, directly by means of a proportional counter, and as ash dispersed in a liquid scintillator. Based on neutron spectrum estimation, a relationship between the neutron dose and induced activity was derived. The experiment verified the practical feasibility of this dosimetry method in cases of criticality accidents or malevolent acts with nuclear materials. - Highlights: • Human hair contains sulfur. • Reaction 32S(n,p)32P can be used for dosimetry of fast neutrons. • Relation between 32P activity and neutron dose can be derived for a specific neutron spectrum

  8. Quality control for handling of accidental blood exposures.

    Wijk, P.T. van; Pelk-Jongen, M.; Wijkmans, C.; Voss, A.; Schneeberger, P.M.

    2006-01-01

    A regional counselling service was established to handle all accidental blood exposures using a standardized protocol. Levels of risk were assessed using an algorithm. Accidents that posed a risk for the transmission of hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV) were

  9. Are diabetic foot lesions precipitated by accidental trauma?

    Doshi, H K; Moissinac, K; Harwant, S

    2001-12-01

    Diabetic foot lesions may arise from frictional trauma due to tight or inappropriate footwear, repetitive stresses on parts of the foot, overlying bony prominence generated by walking and accidental trauma to the neuropathic foot. Many diabetics have been found to be unaware of their foot lesion, or know what the precipitating cause was. Based on the assumption that accidental trauma would affect the foot in a random fashion and result in lesions distributed evenly throughout the foot, a study was performed to determine whether foot lesions were distributed evenly or concentrated to certain areas of predilection. It was found that foot lesions were not evenly distributed but concentrated to certain areas of predilection. Even though relatively high proportion of the study population walked about in open slippers and barefeet, the study showed that accidental trauma was not a predominant precipitant of diabetic foot lesions. Diabetic foot lesions tend to occur as a result of cumulative, repetitive trauma to areas of prediliection rather than accidental trauma. PMID:14569763

  10. Study of stowage of radioactive materials packagings in accidental conditions

    The study of transport conditions shows that few data are available on accidental conditions. Two types of accidents are selected and defined by calculations and tests. Sizing of stowage is determined for a frontal shock (35 g deceleration), maintaining the packaging on the vehicle, and side shock rupture of the stowage system for a determined stress. Mathematical formulations are developed

  11. Brugada syndrome unmasked by accidental inhalation of gasoline vapors

    Kranjcec, Darko; Bergovec, Mijo; Rougier, Jean-Sébastien;

    2007-01-01

    Loss-of-function mutations in the gene SCN5A can cause Brugada syndrome (BrS), which is an inherited form of idiopathic ventricular fibrillation. We report the case of a 46-year-old patient, with no previous medical history, who had ventricular fibrillation after accidental inhalation of gasoline...

  12. Accidental Ingestion of Endodontic File: A Case Report

    Chandak, Manoj G.; Pradnya P. Nikhade; Saraf, Hrushikesh P.

    2012-01-01

    Ingestion of the endodontic instrument during root canal treatment is rare but can result in serious complications. The present paper reports a case in which endodontic file was accidentally swallowed by the patient undergoing root canal therapy, which entered digestive tract and passed uneventfully.

  13. 49 CFR 192.751 - Prevention of accidental ignition.

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Prevention of accidental ignition. 192.751 Section 192.751 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Maintenance § 192.751 Prevention...

  14. The importance of strain localisation in shear zones

    Bons, Paul D.; Finch, Melanie; Gomez-Rivas, Enrique; Griera, Albert; Llorens, Maria-Gema; Steinbach, Florian; Weikusat, Ilka

    2016-04-01

    The occurrence of various types of shear bands (C, C', C'') in shear zones indicate that heterogeneity of strain is common in strongly deformed rocks. However, the importance of strain localisation is difficult to ascertain if suitable strain markers are lacking, which is usually the case. Numerical modelling with the finite-element method has so far not given much insight in the development of shear bands. We suggest that this is not only because the modelled strains are often not high enough, but also because this technique (that usually assumes isotropic material properties within elements) does not properly incorporate mineral deformation behaviour. We simulated high-strain, simple-shear deformation in single- and polyphase materials with a full-field theory (FFT) model coupled to the Elle modelling platform (www.elle.ws; Lebensohn 2001; Bons et al. 2008). The FFT-approach simulates visco-plastic deformation by dislocation glide, taking into account the different available slip systems and their critical resolved shear stresses in relations to the applied stresses. Griera et al. (2011; 2013) have shown that this approach is particularly well suited for strongly anisotropic minerals, such as mica and ice Ih (Llorens 2015). We modelled single- and polyphase composites of minerals with different anisotropies and strengths, roughly equivalent to minerals such as ice Ih, mica, quartz and feldspar. Single-phase polycrystalline aggregates show distinct heterogeneity of strain rate, especially in case of ice Ih, which is mechanically close to mica (see also Griera et al. 2015). Finite strain distributions are heterogeneous as well, but the patterns may differ from that of the strain rate distribution. Dynamic recrystallisation, however, usually masks any strain and strain rate localisation (Llorens 2015). In case of polyphase aggregates, equivalent to e.g. a granite, we observe extensive localisation in both syn- and antithetic shear bands. The antithetic shear bands

  15. Source localisation and dose verification for a novel brachytherapy unit

    Metaxas, Marinos G.

    A recent development in the field of radiotherapy has been the introduction of the PRS Intrabeam system (Carl Zeiss Surgical GmbH, Oberkochen, Germany). This is essentially a portable, miniaturised, electron-driven photon generator that allows high intensity, soft-energy x-rays (50 kVp) to be delivered directly to the tumour site in a single fraction. The system has been used for the interstitial radiation treatment of both brain and breast tumours. At present, a standardised in-vivo dose verification technique is not available for the PRS treatments. The isotropical distribution of photons about the tip of the PRS probe inserted in the tissue can effectively be viewed as a point source of radiation buried in the body. This work has looked into ways of localising the PRS source utilising its own radiation field. Moreover, the response of monoenergetic sources, mimicking realistic brachytherapy sources, has also been investigated. The purpose of this project was to attempt to localise the source as well as derive important dosimetric information from the resulting image. A detection system comprised of a well-collimated Germanium detector (HPGe) has been devised in a rotate-translate Emission Computed Tomography (ECT) modality. The superior energy resolving ability of the detection system allowed for energy selective reconstruction to be carried out in the case of the monoenergetic source (241Am). Results showed that the monoenergetic source can be localised to within 1 mm and the continuous PRS x-ray source to within 3mm. For the PRS dose map derivation, Monte Carlo studies have been employed in order to extract information on the dosimetric aspect of the resulting image. The final goal of this work was therefore to formulate a direct mathematical relation (Transform Map) between the image created by the escaping photons and the dose map as predicted by the theoretical model. The formation therefore of the in-vivo PRS image could allow for a real-time monitoring

  16. A size-dependent constitutive modelling framework for localised failure analysis

    Nguyen, Giang D.; Nguyen, Chi T.; Nguyen, Vinh P.; Bui, Ha H.; Shen, Luming

    2016-08-01

    Localised deformation of materials usually takes place in thin bands during the nonlinear phase of the deformation process. The orientation and size of these localisation bands are important properties characterising the post-localisation behaviour of the materials, and hence should be taken into account in constitutive modelling. In this research, a new approach is proposed for the integration of both size and orientation of a localisation band in the constitutive description beyond the onset of localisation. Since a length scale related to the size of the localisation band appears in the model description, its post-localisation response then scales with both the band size and the size of the volume element containing it. Therefore, size effects are intrinsically included and post-localisation behaviour is correctly captured, which helps ensure convergence of numerical solutions upon discretisation refinement in numerical analysis of boundary value problems. The concept together with implementation features of the framework and its performances at constitutive level and in the analysis of boundary value problems are presented in this paper.

  17. Responsabilidad del empleador por accidentes de trabajo y enfermedades profesionales

    Cristina Mangarelli

    2014-01-01

    Full Text Available Introducción. 1. Responsabilidad del “empleador” por accidentes de trabajo y enfermedades profesionales. Noción. 2. La indemnización “tarifada”. Fundamento de su procedencia 3. Responsabilidad del empleador por accidentes de trabajo o enfermedades profesionales en la ley uruguaya (ley Nº 16.074. 4. La “ampliación” de la responsabilidad del empleador por el derecho común en el derecho uruguayo (artículo 7 ley Nº 16.074. 5. Requisitos para la ampliación de la responsabilidad patronal: culpa grave en el incumplimientode normas de seguridad y prevención. 6. La culpa grave. Concepto. 7. El modelo del hombre a tener en cuenta en la “culpa grave” no es el del buen padre de familia. 8. El grado de la culpa no puede ser medido por el resultado del accidente. 9. Se aplican las eximentes de la responsabilidad civil. 10. Distintos ámbitos de la responsabilidad patronal por accidentes de trabajo o enfermedades profesionales: A ante la víctima o los derecho-habientes; B ante el Banco de Seguros del Estado; C ante el Ministerio de Trabajo ySeguridad Social. 11. Recupero del BSE en caso de culpa grave en el incumplimiento de normas de seguridad y prevención. Requisitos 12. Responsabilidad del empleador en caso de accidente de trabajo o enfermedad profesional sufrido por un adolescente. Conclusiones.

  18. Localised structures in 2D Kolmogorov flow in large domains: Kinks, Snakes and 'Kolmotons'

    Lucas, Dan

    2013-01-01

    Kolmogorov flow in two dimensions - the 2D Navier-Stokes equations with a sinusoidal body force - is considered over extended periodic domains to reveal localised spatiotemporal complexity. The flow response mimicks the forcing at small forcing amplitudes but beyond a critical value, the vorticity of the flow localises into `kink' structures. These kinks act as building blocks for multiple localised attractors which emerge as the forcing further intensifies. Most notable of these is a temporally-periodic state which consists of two intertwined and wiggling kinks (resembling a snake) bordered by two steady chaperoning kinks. As the forcing is increased, this `snake' experiences a period doubling cascade to spatially-localised chaos before becoming a localised chaotic repeller through a boundary crisis. Further interesting dynamics arise when these kink and snake structures are confronted with each other. The most eye-catching example of this is the `particle-like' interaction of propagating kinks (christened `...

  19. Globally reasoning about localised security policies in distributed systems

    Hernandez, Alejandro Mario

    control decisions of the system, and the Semantics also takes care of this. Using the Semantics, a Labelled Transition System (LTS) can be induced for every particular system, and over this LTS some model checking tasks could be done. We identify how this LTS is indeed obtained, and propose an alternative......In this report, we aim at establishing proper ways for model checking the global security of distributed systems, which are designed consisting of set of localised security policies that enforce specific issues about the security expected. The systems are formally specified following a syntax...... way of model checking the not-yet-induced LTS, by using the system design directly. This may lead to over-approximation thereby producing imprecise, though safe, results. We restrict ourselves to finite systems, in the sake of being certain about the decidability of the proposed method. To illustrate...

  20. Simultaneous Mapping and Localisation for Small Military Unmanned Underwater Vehicle

    Arom Hwang

    2012-07-01

    Full Text Available Paper proposes a simultaneous localisation and mapping (SLAM scheme which is applicable to small military unmanned underwater vehicles (UUVs. The SLAM is a process which enables concurrent estimation of the position of UUV and landmarks in the environment through which the vehicle is passing. An unscented Kalman filter (UKF is utilised to develop a SLAM suitable to nonlinear motion of UUV. A range sonar is used as a sensor to collect the relative position information of the landmark in the environment in which the UUV is navigating. The proposed SLAM scheme was validated through towing tank experiments about two degrees of freedom motion with UUV motion simulator and real range sonar system for small UUV. The results of these experiments showed that proposed SLAM scheme is capable of estimating the position of the UUV and the surrounding objects under real underwater environment.

  1. Survival after radical prostatectomy for clinically localised prostate cancer

    Røder, Martin Andreas; Brasso, Klaus; Christensen, Ib Jarle; Johansen, Jørgen; Langkilde, Niels-Christian; Hvarness, Helle; Carlsson, Steen; Jakobsen, Henrik; Borre, Michael; Iversen, Peter

    2014-01-01

    OBJECTIVES: To describe survival and cause of death in a nationwide cohort of Danish patients with prostate cancer undergoing radical prostatectomy (RP). To describe risk factors associated with prostate cancer mortality. PATIENTS AND METHODS: Observational study of 6489 men with localised prostate...... cancer treated with RP at six different hospitals in Denmark between 1995 and 2011. Survival was described using Kaplan-Meier estimates. Causes of death were obtained from the national registry and cross-checked with patient files. Cumulative incidence of death, any cause and prostate cancer......-specific, was described using Nelson-Aalen estimates. Risk for prostate cancer death was analysed in a Cox multivariate regression model using the covariates: age, cT-category, PSA level and biopsy Gleason score. RESULTS: The median follow-up was 4 years. During follow-up, 328 patients died, 109 (33.2%) from...

  2. A search for moment localisation in UMn2

    μSR, high resolution neutron powder diffraction and heat capacity have been used to study the spin fluctuation compound UMn2. The μSR spectra are dominated by muon depolarisation due to static fields from the Mn nuclei, features in the temperature dependence of the associated relaxation rate, σ, correlating well with the structural transitions observed at 210K. While a weak exponential relaxation (λ ∼ 0.01μs-1) indicates the presence of atomic spin fluctuations between 50K and 325K, μSR provides little evidence of moment localisation or long range magnetic order, although an anomalous increase in σ below 40K is observed. (orig.)

  3. Dark matter and localised fermions from spherical orbifolds?

    Cacciapaglia, Giacomo; Deutschmann, Nicolas

    2016-01-01

    We study a class of six-dimensional models based on positive curvature surfaces (spherical 2-orbifolds) as extra-spaces. Using the Newman-Penrose formalism, we discuss the particle spectrum in this class of models. The fermion spectrum problem, which has been addressed with flux compactifications in the past, can be avoided using localised fermions. In this framework, we find that there are four types of geometry compatible with the existence of a stable dark matter candidate and we study the simplest case in detail. Using the complementarity between collider resonance searches and relic density constraints, we show that this class of models is under tension, unless the model lies in a funnel region characterised by a resonant Higgs s-channel in the dark matter annihilation.

  4. Law of Localised Fine Structure with application in mass spectrometry

    Łącki, Mateusz Krzysztof

    2014-01-01

    This paper presents a brand new methodology to deal with isotopic fine structure calculations. By using the Poisson approximation in an entirely novel way, we introduce mathematical elegance into the discussion on the trade-off between resolution and tractability. Our considerations unify the concepts of fine-structure, equatransneutronic configurations, and aggregate isotopic structure in a natural and simple way. We show how to boost the theoretical resolution in a seemingly costless way by several orders of magnitude with respect to the already very efficient algorithms operating on isotopic aggregates. We also develop an effective new way to obtain the important peaks in the most disaggregated isotopic structure localised in a precise region in the mass domain.

  5. 40 CFR 63.95 - Additional approval criteria for accidental release prevention programs.

    2010-07-01

    ... accidental release prevention programs. 63.95 Section 63.95 Protection of Environment ENVIRONMENTAL... Additional approval criteria for accidental release prevention programs. (a) A State submission for approval... (“federally-listed chemicals”) that an approvable State Accidental Release Prevention program is...

  6. A method to achieve rapid localised deep heating in a laser irradiated solid density target

    Schmitz, Holger

    2016-01-01

    Rapid heating of small buried regions by laser generated fast electrons may be useful for applications such as XUV radiation sources or as drivers for shock experiments. In non-structured targets the heating profile possesses a global maximum near the front surface. This paper presents a new target design that uses resistive guiding to concentrate the fast electron current density at a finite depth inside the target. The choice of geometry uses principles of non-imaging optics. A global temperature maximum at depths up to 50{\\mu}m into the target is achieved. Although theoretical calculations suggest that small source sizes should perform better than large ones, simulations show that a large angular spread at high intensities results in significant losses of the fast electrons to the sides. A systematic parameter scan suggests an optimal laser intensity. A ratio of 1.6 is demonstrated between the maximum ion temperature and the ion temperature at the front surface.

  7. Investigation of thermoluminescence properties of mobile phone screen displays as dosimeters for accidental dosimetry

    The rapid assessment of the radiation dose after unexpected exposure is a task of accidental dosimetry. In case of a radiological accident glasses originating from mobile phone screens, placed usually near the human body, could be used as emergency thermoluminescent (TL) personal dosimeters. The time between irradiation and TL readout is crucial and therefore preparation of the mobile phone screens and their readout conditions should be optimized. The influence of the samples etching, bleaching and selection of the optical filters based on measurement of the emission spectrum of irradiated glass samples during heating for different types of mobile phones were the subjects of our investigation. Obtained results showed that glasses extracted from different brands of mobile phones have different dosimetric properties but all of them give a luminescent signal which can be used to calculate the dose. - Highlights: • Application of acids mixture for more effective glass samples etching. • Bleaching can be performed not only by blue but also by UV light. • The readout with BG39 optical filter improves the TL signal intensity. • The glass samples from touch mobile phones are worse emergency TL dosimeters

  8. Colonoscopy and computerised tomography scan are not sufficient to localise right sided colonic lesions accurately.

    Solon, Jacqueline Gemma

    2009-11-23

    : Aim: accurate pre-operative localisation of colonic lesions is critical especially in laparoscopic colectomy where tactile localisation is absent particularly in screen-detected tumours. The study aimed to evaluate the accuracy of colonoscopy and double-contrast computerised tomography (CT) to localise lesions treated by right hemicolectomy. Method: a retrospective chart review was performed of patients treated by right hemicolectomy under the colorectal service between July 2003 and October 2006. Pre-operative tumour location determined by CT scan and colonoscopy were compared with the intra-operative and histopathologic findings. Results: of 101 patients, 73 (73%) were for adenoma or cancer, with a final diagnosis of adenocarcinoma in 59 (59%). Pre-operative localisation was inaccurate in 29% of lesions using both CT and colonoscopy. In the transverse colon colonoscopy alone was only 37.5% accurate, increasing to 62.5% when information from the CT scan was added. Conclusion: pre-operative localisation of right-sided colon cancers using colonoscopy and CT scanning is unreliable in at least 29% of cases. Inaccurate localisation of transverse colon tumours risks inadequate lymphadenectomy with an adverse cancer outcome. Pre-operative abdominal CT scan improves accuracy but endoscopic tattoo localisation should be employed routinely especially in patients undergoing laparoscopic resection.

  9. Accidental intraoral injection of formalin during extraction: case report.

    Swami, Pushp Chander; Raval, Rushik; Kaur, Mandeep; Kaur, Jasleen

    2016-04-01

    Transparent, clear solutions such as hydrogen peroxide, alcohol, sodium hypochlorite, formaldehyde, and local anaesthetics are widely used in dentistry, so the tissues are liable to accidental injury. Formalin, a 37%-40% solution of formaldehyde, is extensively used in 10% solution as a tissue preservative, but it has toxic effects on systems such as the gastrointestinal tract, respiratory tract, skin, and mucosa. However, we know of few reports of cases of inadvertent injection of alcohol and formalin directly into the human body. In this case report we describe the early and delayed clinical effects of accidental intraoral injection of formalin, the subsequent symptoms and management, and some prudent points that should be learnt to avoid such incidents in the future. PMID:26794082

  10. Leading global projects for professional and accidental project leaders

    Moran, Robert T

    2008-01-01

    This book is a must-read for anyone responsible for projects and initiatives that span functional and geographical divides. Authors Moran and Youngdahl bring extensive experience and learning from industry practice to present a clear and straightforward treatment of the leadership skills and knowledge required to lead projects that are global in nature. They have written the first book of its kind to address the three essential skills of global project leaders - strategic project management, project leadership, and cross-cultural leadership. The authors argue that global project leadership is an essential skill in our project-based world and that we are all either intentional or accidental project leaders. Intentional project leaders pursue formal project management education and even certification whereas accidental project leaders find themselves leading global projects and initiatives as a result of a special assignment or promotion. Moran and Youndahl have found that the vast majority of global projects ...

  11. Accidental degeneracy of double Dirac cones in a phononic crystal

    Chen, Ze-Guo

    2014-04-09

    Artificial honeycomb lattices with Dirac cone dispersion provide a macroscopic platform to study the massless Dirac quasiparticles and their novel geometric phases. In this paper, a quadruple-degenerate state is achieved at the center of the Brillouin zone in a two-dimensional honeycomb lattice phononic crystal, which is a result of accidental degeneracy of two double-degenerate states. In the vicinity of the quadruple-degenerate state, the dispersion relation is linear. Such quadruple degeneracy is analyzed by rigorous representation theory of groups. Using method, a reduced Hamiltonian is obtained to describe the linear Dirac dispersion relations of this quadruple-degenerate state, which is well consistent with the simulation results. Near such accidental degeneracy, we observe some unique properties in wave propagating, such as defect-insensitive propagating character and the Talbot effect.

  12. Internal {alpha} activity: localisation, compositional associations and effects on OSL signals in quartz approaching {beta} saturation

    Burbidge, C.I. [Instituto Tecnologico e Nuclear, Sacavem (Portugal)], E-mail: christoph@itn.pt; Dias, M.I.; Prudencio, M.I. [Instituto Tecnologico e Nuclear, Sacavem (Portugal); Rebelo, L.P. [DGM, INETI, Departamento de Geologia Marinha, Alfragide (Portugal); Cardoso, G. [Instituto Tecnologico e Nuclear, Sacavem (Portugal); Brito, P. [DGM, INETI, Departamento de Geologia Marinha, Alfragide (Portugal)

    2009-05-15

    Luminescence signals from hydrofluoric acid etched grains of quartz from Mozambican dunes were investigated in terms of elemental impurities, structural defects, and their relationship to internal {alpha} activity, to examine the potential for this to cause differences in signal levels obtainable from natural and laboratory irradiated samples. Optical and scanning electron microscopy (SEM), X-ray fluorescence (XRF) and instrumental neutron activation analysis (INAA) indicated the presence of various types of quartz and mineralogical inclusions. A spatial association of Th and U with Fe in structural defects was observed. Fe concentrations and inclusion sizes indicated that internal {alpha} dose rate would affect the defects that contained these impurities, but would be insignificant to the bulk quartz. A broad range of optically sensitive thermoluminescence (TL) peaks were observed from this material, and indicated a preheating regime of 260 deg. C for 30 s to minimise effects of the observed inclusions and defects on absorbed dose determinations by optically stimulated luminescence (OSL). Growth in OSL with dose from etched coarse grains preheated in this way approached saturation by 332 Gy of {beta} irradiation ({sup 90}Sr/{sup 90}Y) and by 4 kGy of {alpha} irradiation (E {approx} 3.5 MeV: approximate natural soil spectrum average, using converted dose rate from {sup 241}Am). This indicated {alpha}-efficiency (k{sub eff}) at saturation of less than 0.08. However, the OSL decay curves contained a small 'medium' component. Structural defects introduced by milling the grains produced a larger 'medium' component with a similar decay rate under optical stimulation, which exhibited high saturation doses (>32 kGy{alpha}, >8.4 kGy{beta}) and {alpha}-efficiency (k{sub eff} = 0.34). Maximum dose normalised OSL signals from the milled material greatly exceeded those obtainable from the whole etched grains. It is inferred that the presence of structural

  13. Accidental inhalation of mercury vapour: respiratory and toxicologic consequences.

    Lien, D. C.; Todoruk, D. N.; Rajani, H. R.; Cook, D A; Herbert, F. A.

    1983-01-01

    Four adults, including a pregnant woman, and three children were admitted to hospital following accidental exposure to mercury vapour produced by heating mercury-gold amalgam. Initial symptoms and signs included a paroxysmal cough, dyspnea, chest pain, tachypnea, nausea, vomiting, fever and leukocytosis. Pulmonary function testing performed on the second day after exposure revealed air-flow obstruction and minor restrictive defects in three patients. The diffusing capacity of the lung for car...

  14. A case of accidental ingestion of ant bait containing fipronil.

    Fung, Hin Tat; Chan, Kar Ki; Ching, Wei Ming; Kam, Chak Wah

    2003-01-01

    A 77-year-old woman accidentally ingested a commercial ant bait containing fipronil without development of obvious toxicity, supporting the safety of this new insecticide as demonstrated in animal studies. However, concentrated agricultural products may be more toxic, and the potential for seizures should not be overlooked. The pharmacological action, mechanism of selective insect toxicity, and clinical effects of fipronil are discussed. PMID:12807306

  15. Kinematics and kinetics of an accidental lateral ankle sprain

    Kristianslund, Eirik; Bahr, Roald; Krosshaug, Tron

    2011-01-01

    Ankle sprains are common during sporting activities and can have serious consequences. Understanding of injury mechanisms is essential to prevent injuries, but only two previous studies have provided detailed descriptions of the kinematics of lateral ankle sprains and measures of kinetics are missing. In the present study a female handball player accidentally sprained her ankle during sidestep cutting in a motion analysis laboratory. Kinematics and kinetics were calculated from 240 Hz recordi...

  16. Paediatric femur fractures at the emergency department: accidental or not?

    Hoytema van Konijnenburg, Eva M M; Vrolijk-Bosschaart, Thekla F; Bakx, Roel; Van Rijn, Rick R

    2016-01-01

    Only a small proportion of all paediatric fractures is caused by child abuse or neglect, especially in highly prevalent long bone fractures. It can be difficult to differentiate abusive fractures from non-abusive fractures. This article focuses on femoral fractures in young children. Based on three cases, this article presents a forensic evidence-based approach to differentiate between accidental and non-accidental causes of femoral fractures. We describe three cases of young children who were presented to the emergency department because of a suspected femur fracture. Although in all cases, the fracture had a similar location and appearance, the clinical history and developmental stage of the child led to three different conclusions. In the first two cases, an accidental mechanism was a plausible conclusion, although in the second case, neglect of parental supervision was the cause for concern. In the third case, a non-accidental injury was diagnosed and appropriate legal prosecution followed. Any doctor treating children should always be aware of the possibility of child abuse and neglect in children with injuries, especially in young and non-mobile children presenting with an unknown trauma mechanism. If a suspicion of child abuse or neglect arises, a thorough diagnostic work-up should be performed, including a full skeletal survey according to the guidelines of the Royal College of Radiologists and the Royal College of Paediatrics and Child Health. In order to make a good assessment, the radiologist reviewing the skeletal survey needs access to all relevant clinical and social information. PMID:26642309

  17. The Classification of Accidental Situations’ Scenarios on Hydropower Plants

    Skvortsova Olga; Dashkina Anastasiia; Petrovskaia Ekaterina; Terleev Vitaly; Nikonorov Aleksandr; Badenko Vladimir; Volkova Yulia; Pavlov Sergey

    2016-01-01

    The collapse of hydropower plant could lead to significant financial, social and environmental damages. Accordingly the issue of safety and reliability is one of major problems of designing, maintenance and operation. The proposed solution consists in evaluation of implementation frequency of emergencies scenario, which can be defined by suggested classification of accidental situations’ scenarios based on systems analysis to implement incidents on hydropower plants. Emergency scenarios on hy...

  18. Accidental Symmetries and N=1 Duality in Supersymmetric Gauge Theory

    Leigh, Robert G; Leigh, Robert G.; Strassler, Matthew J.

    1996-01-01

    We note that the accidental symmetries which are present in some examples of duality imply the existence of continuously infinite sets of theories with the same infrared behavior. These sets interpolate between theories of different flavors and colors; the change in color and flavor is compensated by interactions (often non-perturbative) induced by operators in the superpotential. As an example we study the behavior of SU(2) gauge theories with 2\

  19. Conservative management of accidental gall bladder puncture during percutaneous nephrolithotomy

    Patil, Nikhil A.; Kundargi, Vinay S.; Patil, Siddangouda B.; Biradar, Ashok N.; Desai, Anup S.

    2014-01-01

    Percutaneous nephrolithotomy (PCNL) has been an excellent option for the management of kidney stones. There have been many complications in regards to solid organ injury during PCNL. Here we discuss an interesting case of 45-year-old woman, who underwent PCNL for right renal staghorn calculus, and had an accidental puncture of the gall bladder. Post operatively, the patient was conservatively managed and recovered well. A small number of cases has been reported until now in literature.

  20. Accidental Sulfur Poisoning in a Group of Holstein Heifers

    Gunn, Moira F.; Baird, John D.; Wilkie, Judith S. Nimmo

    1987-01-01

    Fourteen animals died or were euthanized after toxic levels of elemental sulfur were accidentally fed to a group of 120 Holstein heifers. Dehydration, rumen stasis, tachycardia, and diarrhea were seen along with metabolic acidosis, hypokalemia, and hypochloremia. The majority of deaths occurred from 3 to 10 days after the sulfur was fed to the heifers. Postmortem examination showed rumenitis, acute alveolitis, and renal tubular necrosis. The toxicity of ingested sulfur was attributed to the c...

  1. Timing, ``Accidentals'' and Other Artifacts in EPR Experiments

    Thompson, Caroline H.

    1997-01-01

    Subtraction of ``accidentals'' in Einstein-Podolsky-Rosen experiments frequently changes results compatible with local realism into ones that appear to demonstrate non-locality. The validity of the procedure depends on the unproven assumption of the independence of emission events. Other possible sources of bias include enhancement, imperfect synchronisation, over-reliance on rotational invariance, and the well-known detection loophole. Investigation of existing results may be more fruitful t...

  2. Accidental catheterization of epidural venous plexus: tomographic analysis

    Mariano Paiva Souza

    2016-04-01

    Full Text Available ABSTRACT BACKGROUND AND OBJECTIVES: Inadvertent venous catheterizations occur in approximately 9% of lumbar epidural anesthetic procedures with catheter placement and, if not promptly recognized, can result in fatal consequences. The objective of this report is to describe a case of accidental catheterization of epidural venous plexus and its recording by computed tomography with contrast injection through the catheter. CASE REPORT: A female patient in her sixties, physical status II (ASA, underwent conventional cholecystectomy under balanced general anesthesia and an epidural with catheter for postoperative analgesia. During surgery, there was clinical suspicion of accidental catheterization of epidural venous plexus because of blood backflow through the catheter, confirmed by the administration of a test dose through the catheter. After the surgery, a CT scan was obtained after contrast injection through the catheter. Contrast was observed all the way from the skin to the azygos vein, passing through anterior and posterior epidural venous plexuses and intervertebral vein. CONCLUSION: It is possible to identify the actual placement of the epidural catheter, as well as to register an accidental catheterization of the epidural venous plexus, using computed tomography with contrast injection through the epidural catheter.

  3. Accidental dural puncture rates in UK obstetric practice.

    Gleeson, C M; Reynolds, F

    1998-10-01

    Headache following epidural analgesia is a common cause of complaint, but accidental dural puncture rates vary among hospitals and with techniques. We were therefore interested to discover the extent of audit of dural puncture, the dural puncture rates in those UK centres that kept reliable records, and the techniques they used for detecting the epidural space. Consultants in charge of anaesthetic services to all 257 obstetric units in the UK were sent a questionnaire requesting numbers of obstetric epidurals, techniques used to detect the epidural space and the numbers of accidental dural punctures in the years 1991-1995. Replies were received from 191 respondents (74%) of whom 104 were able to provide some information about dural puncture rates. Dural puncture rate was inversely related to the number of epidurals performed; the highest recorded rate was 3.6% in a unit with 1000. Most respondents did not record the loss of resistance technique used but among those who did, the dural puncture rate using mainly saline was 0.69% and using mainly air was 1.11% (P<0.001). Since accurate patient information is crucial for informed consent, audit needs to be improved in many centres. Though the accidental dural puncture rate may be under-reported in this survey, our data are in agreement with other findings that loss of resistance to saline is safer than loss of resistance to air. PMID:15321187

  4. Radioguided localisation of impalpable breast lesions using 99m-Technetium macroaggregated albumin: Lessons learnt during introduction of a new technique to guide preoperative localisation

    Landman, Joanne [Department of Nuclear Medicine, Royal Perth Hospital, Perth, Western Australia (Australia); Kulawansa, Sagarika [Department of Diagnostic and Interventional Radiology, Royal Perth Hospital, Perth, Western Australia (Australia); McCarthy, Michael; Troedson, Russell [Department of Nuclear Medicine, Royal Perth Hospital, Perth, Western Australia (Australia); Phillips, Michael [Western Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia (Australia); Tinning, Jill [The Multidisciplinary Breast Service, Royal Perth Hospital, Perth, Western Australia (Australia); Taylor, Donna, E-mail: Donna.Taylor@health.wa.gov.au [Department of Diagnostic and Interventional Radiology, Royal Perth Hospital, Perth, Western Australia (Australia); School of Surgery, University of Western Australia, Perth, Western Australia (Australia); Department of Nuclear Medicine, Royal Perth Hospital, Perth, Western Australia (Australia)

    2015-03-15

    Preoperative wire-guided localisation (WGL) of impalpable breast lesions is widely used but can be technically difficult. Risks include wire migration, inaccurate placement, and inadequate surgical margins. Research shows that radioguided occult lesion localisation (ROLL) is quicker, easier, and can improve surgical and cosmetic outcomes. An audited introduction of ROLL was conducted to validate the technique as a feasible alternative to WGL. Fifty patients with single impalpable lesions and biopsy proven malignancy or indeterminate histology underwent WGL followed by intralesional radiopharmaceutical injection of 99m-Technetium macroaggregated albumin. Postprocedural mammography was performed to demonstrate wire position, and scintigraphy to evaluate radiopharmaceutical migration. Lymphoscintigraphy and intraoperative sentinel node biopsy were performed if indicated, followed by lesion localisation and excision using a gamma probe. Specimen imaging was performed, with immediate reexcision for visibly inadequate margins. Accurate localisation was achieved in 86% of patients with ROLL compared to 72% with WGL. All lesions were successfully removed, with clear margins in 71.8% of malignant lesions. Reexcision and intraoperative sentinel node localisation rates were equivalent to preaudit figures for WGL. ROLL was easy to perform and problems were infrequent. Inaccurate radiopharmaceutical placement necessitating WGL occurred in four patients. Minor radiopharmaceutical migration was common, but precluded using ROLL in only two cases. ROLL is effective, simple, inexpensive, and easily learnt; however, preoperative confirmation of correct radiopharmaceutical placement using mammography and the gamma probe is important to help ensure successful lesion removal. Insertion of a backup hookwire is recommended during the initial introduction of ROLL.

  5. Radioguided localisation of impalpable breast lesions using 99m-Technetium macroaggregated albumin: Lessons learnt during introduction of a new technique to guide preoperative localisation

    Preoperative wire-guided localisation (WGL) of impalpable breast lesions is widely used but can be technically difficult. Risks include wire migration, inaccurate placement, and inadequate surgical margins. Research shows that radioguided occult lesion localisation (ROLL) is quicker, easier, and can improve surgical and cosmetic outcomes. An audited introduction of ROLL was conducted to validate the technique as a feasible alternative to WGL. Fifty patients with single impalpable lesions and biopsy proven malignancy or indeterminate histology underwent WGL followed by intralesional radiopharmaceutical injection of 99m-Technetium macroaggregated albumin. Postprocedural mammography was performed to demonstrate wire position, and scintigraphy to evaluate radiopharmaceutical migration. Lymphoscintigraphy and intraoperative sentinel node biopsy were performed if indicated, followed by lesion localisation and excision using a gamma probe. Specimen imaging was performed, with immediate reexcision for visibly inadequate margins. Accurate localisation was achieved in 86% of patients with ROLL compared to 72% with WGL. All lesions were successfully removed, with clear margins in 71.8% of malignant lesions. Reexcision and intraoperative sentinel node localisation rates were equivalent to preaudit figures for WGL. ROLL was easy to perform and problems were infrequent. Inaccurate radiopharmaceutical placement necessitating WGL occurred in four patients. Minor radiopharmaceutical migration was common, but precluded using ROLL in only two cases. ROLL is effective, simple, inexpensive, and easily learnt; however, preoperative confirmation of correct radiopharmaceutical placement using mammography and the gamma probe is important to help ensure successful lesion removal. Insertion of a backup hookwire is recommended during the initial introduction of ROLL

  6. A machine-hearing system exploiting head movements for binaural sound localisation in reverberant conditions

    May, Tobias; Ma, Ning; Wierstorf, Hagen;

    2015-01-01

    investigated the influence of different head movement strategies on binaural sound localisation. A machine-hearing system that exploits a multi-step head rotation strategy for sound localisation was found to produce the best performance in simulated reverberant acoustic space. This paper also reports the......This paper is concerned with machine localisation of multiple active speech sources in reverberant environments using two (binaural) microphones. Such conditions typically present a problem for ‘classical’ binaural models. Inspired by the human ability to utilise head movements, the current study...

  7. Optimal localisation of next generation Biofuel production in Sweden

    Wetterlund, Elisabeth [Linkoeping Univ., Linkoeping (Sweden); Pettersson, Karin [Chalmers Univ. of Technology, Goeteborg (Sweden); Mossberg, Johanna [SP Technical Research Inst. of Sweden, Boraas (Sweden)] [and others

    2013-09-01

    With a high availability of lignocellulosic biomass and various types of cellulosic by-products, as well as a large number of industries, Sweden is a country of great interest for future large scale production of sustainable, next generation biofuels. This is most likely also a necessity as Sweden has the ambition to be independent of fossil fuels in the transport sector by the year 2030 and completely fossil free by 2050. In order to reach competitive biofuel production costs, plants with large production capacities are likely to be required. Feedstock intake capacities in the range of about 1-2 million tonnes per year, corresponding to a biomass feed of 300-600 MW, can be expected, which may lead to major logistical challenges. To enable expansion of biofuel production in such large plants, as well as provide for associated distribution requirements, it is clear that substantial infrastructure planning will be needed. The geographical location of the production plant facilities is therefore of crucial importance and must be strategic to minimise the transports of raw material as well as of final product. Competition for the available feedstock, from for example forest industries and CHP plants (combined heat and power) further complicates the localisation problem. Since the potential for an increased biomass utilisation is limited, high overall resource efficiency is of great importance. Integration of biofuel production processes in existing industries or in district heating systems may be beneficial from several aspects, such as opportunities for efficient heat integration, feedstock and equipment integration, as well as access to existing experience and know-how. This report describes the development of Be Where Sweden, a geographically explicit optimisation model for localisation of next generation biofuel production plants in Sweden. The main objective of developing such a model is to be able to assess production plant locations that are robust to varying

  8. Simultaneous Mapping and Localisation for Small Military Unmanned Underwater Vehicle

    Arom Hwang

    2012-07-01

    Full Text Available Paper proposes a simultaneous localisation and mapping (SLAM scheme which is applicable to small military unmanned underwater vehicles (UUVs. The SLAM is a process which enables concurrent estimation of the position of UUV and landmarks in the environment through which the vehicle is passing. An unscented Kalman filter (UKF is utilised to develop a SLAM suitable to nonlinear motion of UUV. A range sonar is used as a sensor to collect the relative position information of the landmark in the environment in which the UUV is navigating. The proposed SLAM scheme was validated through towing tank experiments about two degrees of freedom motion with UUV motion simulator and real range sonar system for small UUV. The results of these experiments showed that proposed SLAM scheme is capable of estimating the position of the UUV and the surrounding objects under real underwater environment.Defence Science Journal, 2012, 62(4, pp.223-227, DOI:http://dx.doi.org/10.14429/dsj.62.1002

  9. Preferred water flow and localised recharge in a variable regolith

    Johnston, Colin D.

    1987-10-01

    The mechanisms of water flow and recharge to groundwater were investigated in a deep clayey regolith in southwest Western Australia. A 700 m 2 area was intensively studied for a period of two years. Vertical distributions of natural chloride in thirteen profiles up to 31 m deep were used to estimate the distribution of vertical soil-water flux density in the 16 m unsaturated zone and rates of recharge to groundwater. Groundwater dynamics were monitored using ten single and four multilevel piezometers. The regolith showed marked heterogeneity over horizontal and vertical distances of only a few metres. This resulted in complex patterns of water and solute movement through the profiles. Over most of the experimental area, vertical water flux density below 5 m in the unsaturated zone was from 2.2 to 7.2 mm yr -1. However, within a relatively small portion of the site, vertical soil-water flux density was 50-100 mm yr -1 throughout the unsaturated zone. This flux more closely matched the apparent rate of recharge to groundwater. The area of preferred flow is apparently due to a discontinuity within the regolith. A groundwater mound was seen to develop below the localised recharge area within 12-14 h of intense rainstorms, and then dissipated over a period of 2-4 days.

  10. Embedded discontinuous Galerkin transport schemes with localised limiters

    Cotter, C. J.; Kuzmin, D.

    2016-04-01

    Motivated by finite element spaces used for representation of temperature in the compatible finite element approach for numerical weather prediction, we introduce locally bounded transport schemes for (partially-)continuous finite element spaces. The underlying high-order transport scheme is constructed by injecting the partially-continuous field into an embedding discontinuous finite element space, applying a stable upwind discontinuous Galerkin (DG) scheme, and projecting back into the partially-continuous space; we call this an embedded DG transport scheme. We prove that this scheme is stable in L2 provided that the underlying upwind DG scheme is. We then provide a framework for applying limiters for embedded DG transport schemes. Standard DG limiters are applied during the underlying DG scheme. We introduce a new localised form of element-based flux-correction which we apply to limiting the projection back into the partially-continuous space, so that the whole transport scheme is bounded. We provide details in the specific case of tensor-product finite element spaces on wedge elements that are discontinuous P1/Q1 in the horizontal and continuous P2 in the vertical. The framework is illustrated with numerical tests.

  11. Major lower intestinal haemorrhage: angiographic localisation and current management

    Thirty-four patients with major lower intestinal bleeding underwent emergency selective mesenteric angiography during a 6-year period. Angiography identified a bleeding site in 16 patients (47%). Diverticulosis, found in 22 patients (65%), and angiodysplasia, found in 4 (12%), were the most common causes of major colonic bleeding and originated more frequently from the right colon. Eight patients (24%) bled from less common sources. Radiological control of bleeding was unreliable with a significant complication rate. Fourteen of 16 patients with positive angiograms and 6 of 18 patients with negative angiograms required surgery for persistent major bleeding. Angiographic localisation of colonic bleeding allowed limited resection in 9 of 11 patients with control of haemorrhage in 8 (89%). Fourteen of 34 patients were managed non-operatively; of these 2 had minor recurrent bleeding. The overall mortality rate was 29%, the operative mortality rate 40% and the non-operative mortality rate 14%. A rational diagnostic approach is presented, emphasising the role of selective mesenteric angiography in the management and surgical strategy of major lower intestinal bleeding

  12. A method for accurate localisation of EBSD pattern centres

    Maurice, Claire, E-mail: maurice@emse.fr [SMS Centre, UMR CNRS 5146, Ecole des Mines de Saint-Etienne, 158 cours Fauriel, 42023 Saint-Etienne, Cedex 2 (France); Dzieciol, Krzysztof, E-mail: dzieciol@emse.fr [SMS Centre, UMR CNRS 5146, Ecole des Mines de Saint-Etienne, 158 cours Fauriel, 42023 Saint-Etienne, Cedex 2 (France); Fortunier, Roland, E-mail: fortunier@emse.fr [SMS Centre, UMR CNRS 5146, Ecole des Mines de Saint-Etienne, 158 cours Fauriel, 42023 Saint-Etienne, Cedex 2 (France)

    2011-01-15

    The moving screen technique for pattern centre localisation is revisited. A cross-correlation based iterative procedure is developed to find both the zoom factor and the zoom centre (which is also the pattern centre) between two EBSD diffraction patterns acquired at two camera positions. The procedure involves two steps: first, a rough estimate of the pattern centre position and zoom factor (the ratio of the two detector distances) is obtained by cross-correlating the entire images. Then, based on this first estimate, cross-correlation of smaller regions of interest (ROIs) gives the displacement field which is interpreted as a zoom factor misfit coupled with a zoom centre position misfit. These misfits are iteratively decreased until the displacement field is reduced to the noise level. The procedure is first applied to simulated patterns and it is shown that the iterative procedure converges very rapidly to the exact solution with an accuracy better than 1/100th of pixel. The potential of this technique for experimental patterns is discussed and recommendations for new EBSD detectors are proposed. -- Research Highlights: {yields}Numerical and experimental study of measuring the pattern centre of EBSD patterns. {yields}Advanced moving screen technique coupled with sub-pixel cross-correlation. {yields}In theory, using simulated patterns, the precision is of the order of 1/100th pixel. {yields}In practice, the precision is drastically reduced due to camera imperfections. {yields}Methods of improving camera design for high resolution EBSD are outlined.

  13. Ignalina accident localisation system response to maximum design basis accident

    In this paper the study of the accident localisation system (ALS) of the Ignalina nuclear power plant (NPP) with RBMK-1500 reactors (large-power channel-type water-cooled graphite-moderated reactor) with regard to a maximum design basis accident (MDBA) is presented. The MDBA for Ignalina NPP constitutes a guillotine rupture of the maximum diameter pipe. The thermal-hydraulic and structural analyses were performed using the RELAP5, CONTAIN and ALGOR codes. The coolant mass and energy discharge source terms to the accident compartment were established using the RELAP5 code. This was then used as a source term for the long-term accident thermal-hydraulic analysis of ALS compartments employing the CONTAIN code. Results obtained by the CONTAIN calculations establish a basis for the structural analysis. A finite-element method has been used for ALS structural analysis using the ALGOR code, the results of which show that the structures of the ALS would not be breached by the pressure attained in the event of an MDBA. (author)

  14. Localised excitation of a single photon source by a nanowaveguide

    Geng, Wei; Manceau, Mathieu; Rahbany, Nancy; Sallet, Vincent; de Vittorio, Massimo; Carbone, Luigi; Glorieux, Quentin; Bramati, Alberto; Couteau, Christophe

    2016-01-01

    Nowadays, integrated photonics is a key technology in quantum information processing (QIP) but achieving all-optical buses for quantum networks with efficient integration of single photon emitters remains a challenge. Photonic crystals and cavities are good candidates but do not tackle how to effectively address a nanoscale emitter. Using a nanowire nanowaveguide, we realise an hybrid nanodevice which locally excites a single photon source (SPS). The nanowire acts as a passive or active sub-wavelength waveguide to excite the quantum emitter. Our results show that localised excitation of a SPS is possible and is compared with free-space excitation. Our proof of principle experiment presents an absolute addressing efficiency ηa ~ 10-4 only ~50% lower than the one using free-space optics. This important step demonstrates that sufficient guided light in a nanowaveguide made of a semiconductor nanowire is achievable to excite a single photon source. We accomplish a hybrid system offering great potentials for electrically driven SPSs and efficient single photon collection and detection, opening the way for optimum absorption/emission of nanoscale emitters. We also discuss how to improve the addressing efficiency of a dipolar nanoscale emitter with our system.

  15. Localisation and Acquisition of Knowledge in Software Developing Organisations in the Light of Empirical Research

    Chrabański, Karol

    2013-01-01

    The purpose of the paper is to present the organisation and results of the empirical research facilitating the localisation and acquisition of knowledge in software developing organisations which have designed, documented, implemented and maintain quality management systems.The author's interest is focused on presenting a project of empirical research aimed at the localisation and acquisition of knowledge in software developing organisations.The paper contains an assessment of the usability o...

  16. Computer modelling of response of the Modelo-2 gamma probe used in intraoperative localisation of tumors

    During the last decade hand-held gamma probes have been introduced into both tumor localisation and surgery. The technique, labelled RIGA (radioimmuno-guided endoscopy), proved to be of help in various stages of the patient treatment preoperational (localisation, as accurate, as possible of even small-size tumor targets), intraoperational (an on-line assessment of the efficiency of the radical surgery) and postoperational, identification of possible local recurrence and metastases

  17. In planta localisation patterns of MADS domain proteins during floral development in Arabidopsis thaliana

    Kaufmann Kerstin

    2009-01-01

    Full Text Available Abstract Background MADS domain transcription factors play important roles in various developmental processes in flowering plants. Members of this family play a prominent role in the transition to flowering and the specification of floral organ identity. Several studies reported mRNA expression patterns of the genes encoding these MADS domain proteins, however, these studies do not provide the necessary information on the temporal and spatial localisation of the proteins. We have made GREEN FLUORESCENT PROTEIN (GFP translational fusions with the four MADS domain proteins SEPALLATA3, AGAMOUS, FRUITFULL and APETALA1 from the model plant Arabidopsis thaliana and analysed the protein localisation patterns in living plant tissues by confocal laser scanning microscopy (CLSM. Results We unravelled the protein localisation patterns of the four MADS domain proteins at a cellular and subcellular level in inflorescence and floral meristems, during development of the early flower bud stages, and during further differentiation of the floral organs. The protein localisation patterns revealed a few deviations from known mRNA expression patterns, suggesting a non-cell autonomous action of these factors or alternative control mechanisms. In addition, we observed a change in the subcellular localisation of SEPALLATA3 from a predominantly nuclear localisation to a more cytoplasmic localisation, occurring specifically during petal and stamen development. Furthermore, we show that the down-regulation of the homeodomain transcription factor WUSCHEL in ovular tissues is preceded by the occurrence of both AGAMOUS and SEPALLATA3 proteins, supporting the hypothesis that both proteins together suppress WUSCHEL expression in the ovule. Conclusion This approach provides a highly detailed in situ map of MADS domain protein presence during early and later stages of floral development. The subcellular localisation of the transcription factors in the cytoplasm, as observed at

  18. Scalable Software-Defect Localisation by Hierarchical Mining of Dynamic Call Graphs

    Eichinger, Frank; Oßner, Christopher; Böhm, Klemens

    2011-01-01

    The localisation of defects in computer programmes is essential in software engineering and is important in domain-specific data mining. Existing techniques which build on call-graph mining localise defects well, but do not scale for large software projects. This paper presents a hierarchical approach with good scalability characteristics. It makes use of novel call-graph representations, frequent subgraph mining and feature selection. It first analyses call graphs of a coarse granularity, be...

  19. Real-time Dense Simultaneous Localisation and Mapping over Large Scale Environments

    Whelan, Thomas J.

    2014-01-01

    The ability for a robot to create a map of an unknown environment and localise within that map is of critical importance in intelligent autonomous operation. This problem is referred to as Simultaneous Localisation and Mapping (or SLAM) and has been one of the major focusses of robotics research over the past 25 years. Although the initial focus was on 2D laser scan SLAM, more recently full 3D SLAM has become the dominant paradigm. The recent expansion in popularity of fu...

  20. Non-Gaussian probabilistic MEG source localisation based on kernel density estimation ☆

    Mohseni, Hamid R.; Kringelbach, Morten L.; Woolrich, Mark W; Baker, Adam; Aziz, Tipu Z; Probert-Smith, Penny

    2014-01-01

    There is strong evidence to suggest that data recorded from magnetoencephalography (MEG) follows a non-Gaussian distribution. However, existing standard methods for source localisation model the data using only second order statistics, and therefore use the inherent assumption of a Gaussian distribution. In this paper, we present a new general method for non-Gaussian source estimation of stationary signals for localising brain activity from MEG data. By providing a Bayesian formulation for ME...

  1. Dual-sensor fusion for seamless indoor user localisation and tracking

    Redzic, Milan

    2013-01-01

    Indoor localisation based on ubiquitous WLAN has exhibited the capability of being a cheap and relatively precise technology and has been verified by many successful examples. Its performance is subject to change due to multipath propagation and changes in the environment (people, building layouts, antenna characteristics etc.) which cannot be easily eliminated. This thesis addresses the automatic localisation of indoor user and proposes solutions for both positioning and seamlessly tracking ...

  2. Intelligent UAV-Assisted Localisation to Conserve Battery Energy in Military Sensor Networks

    P.Shunmuga Perumal

    2014-11-01

    Full Text Available Wireless sensor networks (WSNs are extensively used in military applications for border area monitoring, battle-field surveillance, tracking enemy troops, where the sensor nodes run on battery power. Localisation of sensor nodes is extremely important to identify the location of event in military applications for further actions. Existing localisation algorithms consume more energy by heavy computation and communication overheads. The objective of the proposed research is to increase the lifetime of the military sensor networks by reducing the power consumption in each sensor node during localisation. For the state-of-the-art, we propose a novel intelligent unmanned aerial vehicle anchor node (IUAN with an intelligent arc selection (IAS-based centralised localisation algorithm, which removes computation cost and reduces communication cost at every sensor node. The IUAN collects the signal strength, distance data from sensor nodes and the central control station (CCS computes the position of sensor nodes using IAS algorithm. Our approach significantly removes computation cost and reduces communication cost at each sensor node during localisation, thereby radically extends the lifetime and localisation coverage of the military sensor networks.Science Journal, Vol. 64, No. 6, November 2014, pp.557-563, DOI:http://dx.doi.org/10.14429/dsj.64.5295

  3. Indoor Localisation Using a Context-Aware Dynamic Position Tracking Model

    Montserrat Ros

    2012-01-01

    Full Text Available Indoor wireless localisation is a widely sought feature for use in logistics, health, and social networking applications. Low-powered localisation will become important for the next generation of pervasive media applications that operate on mobile platforms. We present an inexpensive and robust context-aware tracking system that can track the position of users in an indoor environment, using a wireless smart meter network. Our context-aware tracking system combines wireless trilateration with a dynamic position tracking model and a probability density map to estimate indoor positions. The localisation network consisted of power meter nodes placed at known positions in a building. The power meter nodes are tracked by mobile nodes which are carried by users to localise their position. We conducted an extensive trial of the context-aware tracking system and performed a comparison analysis with existing localisation techniques. The context-aware tracking system was able to localise a person's indoor position with an average error of 1.21 m.

  4. localisation et dys-localisation dans le foncier contemporain Delocalization and dyslocalization in land today

    Gérard Chouquer

    2011-10-01

    Full Text Available Dans cet article, l’auteur étudie un aspect des changements majeurs qui affectent le foncier et, notamment, les acquisitions massives de terre, tels l'effet de délocalisation du rapport à la terre et l'éviction de fait des habitants du territoire qu'ils occupent et travaillent. On voit se multiplier les projets dans lesquels la terre fait l'objet d'une contractualisation dont les habitants sont exclus. L'article analyse d'abord le projet de Varun International à Madagascar, abandonné depuis dans le sillage de l'affaire Daewoo et de la chute du gouvernement de M. Ravalomanana. Le contrat envisagé entre Varun International et le gouvernement malgache était un projet d’agriculture contractuelle (contract farming, qui concernait 465 000 hectares et la création de treize périmètres irrigués permettant de produire 2,8 millions de tonnes de riz paddy et 400 000 tonnes de maïs dès la 4e année. Or, ce projet est révélateur pour deux raisons. La première est qu'il organisait l'irresponsabilité sociale de l'entreprise par la multiplication de sociétés-écrans chargées de la libérer des relations avec la population. La seconde est qu'il comportait des clauses économiques iniques, qui conduisaient Varun à contrôler 91 % de la production, et qui aurait conduit les agriculteurs malgaches les plus pauvres à devoir acheter du riz pour leur propre nourriture. Ce projet montre comment on aurait pu aboutir à une délocalisation qui est, en réalité, une dys-localisation, c'est-à-dire un dysfonctionnement du rapport normal au lieu. Ce projet organisait les conditions d'une appropriation de la terre et d'un transfert de production dans un pays qui, par ailleurs, dépend du programme d'aide alimentaire mondial. Les conditions du contrat conduisaient à multiplier les schémas triangulaires, par la création d'intermédiaires censés libérer l'entreprise principale de ses devoirs vis-à-vis des hommes et du sol. Comparant ce

  5. Numerical simulation of industrial and accidental release formation and transport

    Piskunov, V.N.; Aloyan, A.A.; Gerasimov, V.M.; Pinaev, V.S.; Golubev, A.I.; Yanilkin, Yu.V.; Ivanov, N.V.; Nikonov, S.N.; Kharchenko, A.I. [and others

    1995-05-01

    Statement of work for contract 006 {open_quotes}Mathematical simulation of industrial and accidental release formation and transport{close_quotes} implies that the final result of the activity within this task will be VNIIEF developed techniques which will provide for the prediction of the post-accidental environment. Report [1] presents the description of physical models and calculation techniques which were chosen by VNIIEF to accomplish this task. These techniques were analysed for their capabilities, the areas of their application were defined, modifications within contract 006 were described, the results of test and methodical calculations were presented. Moreover, the experimental data were analysed over the source parameters and contamination measurements which can be used in the comparison with the calculation results. Based an these data this report compares the calculation results obtained with VNIIEF calculation techniques with the LANL-presented experimental results. The calculations which statements and results are given in section 1, included the following processes: explosion cloud ascent dynamics and jet release origin; aerosols kinetics in the release source including composite particle origin in the explosion cloud caused by radioactive substance sorption an the soil particles; contaminant transport in atmosphere and their in-site fallout due to the accidental explosions and fires; atmospheric flow dynamics and industrial contamination transfer over the complicated terrain. The calculated results were compared with the experimental data. Section 2 presents the parameters for a typical source in the explosion accidents based an the experimental results and calculated data from Section 1, as well as contamination patterns were calculated with basic technique {open_quotes}Prognosis{close_quotes}.

  6. Localised uptake and extraction of calcium45 in dinoflagellate nuclei

    The uptake of Ca45 into cells of the dinoflagellate Glenodinium foliaceum was investigated using insoluble compound light microscope autoradiography. The distribution of silver grains showed marked localisation to the dinocaryotic nucleus, with a random scatter of grains over the surrounding protoplasm (cytoplasm and supernumerary nucleus). Correction of grain counts for lateral sensitisation from the dinocaryotic nucleus indicated an isotope concentration 16 32 times greater in this organelle compared to the rest of the cell. Cells labelled for varying periods of time showed differences in the pattern of Ca45 uptake throughout the sample populations, but no increase in the mean level of uptake per cell. This would suggest a rapid incorporation of isotope within 1-2 hours, with little subsequent uptake. The presence of high levels of label after processing with both additive (glutaraldehyde, paraformaldehyde) and coagulative (acetic alcohol) fixatives indicated that the retention of Ca45 in these preparations was not simply a fixation artefact. Although the isotope did not appear to be suitable for (high resolution) electron microscope autoradiography, the intranuclear site of incorporation was demonstrated indirectly using a buffer extraction technique. Prolonged treatment with phosphate buffer resulted in a large scale loss of label from both cytoplasm and dinocaryotic nucleus. The latter appeared to show specific correlation with the loss of (protein) matrix from the chromosomes - as observed under both light and electron microscopy, with no apparent change in either nucleolus or nucleoplasm. This would suggest that incorporated Ca45 in the nucleus was largely confined to the condensed chromatin, where it was combined with the acidic proteins which make up the bulk of the chromatin matrix. The results obtained in this investigation are related to previous studies involving X-ray microanalysis and uptake of Ni63. (Author)

  7. Early diagnosis and monitoring of whole-body accidental exposure

    This paper deals with the handling of accidental, acute or protracted, whole-body overexposures. It is complementary to the report DPS 86/07 SEAPS previously published. The criteria for initial classification, as a function of the mean absorbed dose, the clinical and paraclinical evaluation, the monitoring methods and the treatments to undertake are described successively. The basic components of the therapy are the intensive care of the hematological syndrome with blood products transfusions and anti-infection prophylaxy. The indications and conditions for bone-marrow grafts are also discussed

  8. Biokinetics of radionuclides and treatment of accidental intakes

    This paper describes the objectives and reviews the progress of EULEP Working Party 5, convened under the auspices of the European Union's Fifth Framework Programme, to 'cluster' two EU-supported contracts, Biokinetics and Dosimetry of Internal Contamination (BIODOS (EU Contract FIS5-1999-00214)) and Radionuclide Biokinetics Database (EULEP) ( RBDATA-EULEP (Concerted Action Contract FIS5-1999-00218), and two non-EU funded projects, Biokinetics of Radionuclides in Human Volunteers (RNHV (non-EU Funded Project) and Treatment of Accidental Intakes of Radionuclides (TAIR (part-funded by EULEP)). (author)

  9. Accidentes de trabajo en un hospital de agudos

    Pérez Bermúdez B.

    1998-01-01

    Full Text Available FUNDAMENTO: El mejor conocimiento de los determinantes y circunstancias de producción de los accidentes laborales, favorecerá la implantación de medidas correctoras. El objetivo de este trabajo es describir la evolución temporal de los accidentes de trabajo (AT y determinar los factores de riesgo de baja médica en el Hospital Dr. Peset de Valencia. MÉTODOS: Descripción y análisis retrospectivo de los accidentes de trabajo producidos en el Hospital Dr. Peset de Valencia durante los años 1992 a 1995. Se estimó por métodos deterministas la tendencia y estacionalidad de las series (índices estacionales, IE. Se aplicó un modelo de regresión logística para identificar los factores pronósticos de baja médica y determinar su probabilidad de ocurrencia . RESULTADOS: Las tasas más elevadas de AT se produjeron entre los trabajadores de cocina y lavandería (10,00 AT por 100 trabajadores-año. Los AT con baja médica mantienen una tendencia cercana a cero siendo febrero el mes con I.E más elevado (IE=139,8. Los que cursan sin baja médica tienen una tendencia positiva (r²=0,23, p<0,0001, siendo mayo el mes de mayor siniestralidad (IE=134,2. La probabilidad de que el accidente curse con baja médica aumenta significativamente con la edad, cuando se produce por la tarde, si ha tenido lugar en cocina/lavandería, y si se trata de un esguince o tendinitis. CONCLUSIONES: la actuación sobre la siniestralidad en los AT que cursen con IT, debería centrarse sobre los trabajos menos cualificados y en las áreas de cocina y lavandería.

  10. Funciones superiores en pacientes con accidente cerebro vascular.

    Felipe Rodríguez; Alfonso Urzúa

    2009-01-01

    Los estudios realizados en Chile hasta la fecha no permiten detectar de manera significativa el deterioro neuropsicológico causado por el accidente cerebro vascular (ACV) y el impacto que éste tiene en el paciente a nivel de su desenvolvimiento diario y familiar. Con base a esto el objetivo de esta investigación fue elaborar un perfil de deterioro neuropsicológico de las diversas funciones cerebrales superiores causado por un ACV, en un grupo de 50 pacientes de la Unidad de Medicina Física de...

  11. Methemoglobinemia as a result of accidental lacquer thinner poisoning

    Ranju Singh

    2012-01-01

    Full Text Available Lacquer thinner, commonly used for removing household paints, is known to contain a mixture of various aromatic hydrocarbons, halogenated hydrocarbons and naptha; if ingested, it may cause methemoglobinemia. We report two cases who presented to us with a history of accidental ingestion of paint thinner. Both the patients had very high levels of methemoglobin and were treated with methylene blue (MB, but did not respond to the MB therapy. One of them received an exchange transfusion followed again by MB and survived. Unfortunately the other patient succumbed to the poisoning.

  12. ECMO for Cardiac Rescue after Accidental Intravenous Mepivacaine Application

    Michael Froehle

    2012-01-01

    Full Text Available Mepivacaine is a potent local anaesthetic and used for infiltration and regional anaesthesia in adults and pediatric patients. Intoxications with mepivacaine affect mainly the CNS and the cardiovascular system. We present a case of accidental intravenous mepivacaine application and intoxication of an infant resulting in seizure, broad complex bradyarrhythmia, arterial hypotension and finally cardiac arrest. The patient could be rescued by prolonged resuscitations and a rapid initiation of ECMO and survived without neurological damage. The management strategies of this rare complication including promising other treatment options with lipid emulsions are discussed.

  13. Evaluation and mitigation of accidental releases of radioactivity

    One result of the workshop was, that even in the case of severe accident sequences in modern nuclear power plants (other facilities were not discussed), there will be enough time to take active measures in order to lower the emissions and to diminish the consequences inside and outside of the plant. On the whole, new evidence from Harrisburg show that previously estimated accidental emissions, especially of radiologically relevant nuclides, have been rather conservative and that much lower emissions are possible, if the above measures are considered. Under accident conditions, models to predict radiation exposure must be applied under the event of a short-term release. (orig./DG)

  14. Rapid Deployment System for Complex Accidental Release Simulations

    Juruš, Pavel; Eben, Kryštof; Resler, Jaroslav; Belda, M.

    Brno : Masarykova univerzita, 2009 - (Hřebíček, J.; Hradec, J.; Pelikán, E.; Mírovský, O.; Pillmann, W.; Holoubek, I.; Bandholz, T.), s. 312-317 ISBN 978-80-210-4824-9. [Towards eEnvironment. European Conference of the Czech Presidency of the Council of the EU. Prague (CZ), 25.03.2009-27.03.2009] R&D Projects: GA AV ČR 1ET400300414 Institutional research plan: CEZ:AV0Z10300504 Keywords : environmental modelling * accidental release modelling * risk management planning Subject RIV: IN - Informatics, Computer Science

  15. Self-Administered Ethanol Enema Causing Accidental Death

    Thomas Peterson

    2014-01-01

    Full Text Available Excessive ethanol consumption is a leading preventable cause of death in the United States. Much of the harm from ethanol comes from those who engage in excessive or hazardous drinking. Rectal absorption of ethanol bypasses the first pass metabolic effect, allowing for a higher concentration of blood ethanol to occur for a given volume of solution and, consequently, greater potential for central nervous system depression. However, accidental death is extremely rare with rectal administration. This case report describes an individual with klismaphilia whose death resulted from acute ethanol intoxication by rectal absorption of a wine enema.

  16. Tratamiento de Terapia Ocupacional en el accidente cerebrovascular

    Domingo García, AM

    2006-01-01

    RESUMENEntre los muchos pacientes que necesitan tratamiento rehabilitador en Terapia Ocupacional están los que en la edad adulta han sufrido un accidente cerebrovascular.Uno de los factores de riesgo asociados con más frecuencia a las alteraciones del sistema nervioso central es el progresivo envejecimiento de la población, debido a esto orientaré el siguiente artículo hacia la intervención sobre la población geriátrica.La Terapia Ocupacional ofrece un tratamiento global que abarca las áreas ...

  17. Calidad de vida de cuidadores de adultos con accidente cerebrovascular

    INNA ELIDA FLÓREZ TORRES; AMPARO MONTALVO PRIETO; ARLETH HERRERA LIÁN

    2010-01-01

    Objetivo: describir la calidad de vida de los cuidadores familiares de adultos con secuelas de accidente cerebrovascular, en Cartagena, Colombia. Método: estudio descriptivo cuantitativo realizado durante el segundo semestre de 2008. Muestra no probabilística por conveniencia de 97 cuidadores. Se empleó el instrumento propuesto por Ferrell et ál. Para valorar cada uno de los bienestares que integran la calidad de vida se utilizaron medidas de tendencia central y coeficiente de variación. Resu...

  18. Clinical perspectives on osteogenesis imperfecta versus non-accidental injury.

    Pereira, Elaine Maria

    2015-12-01

    Although non-accidental injuries (NAI) are more common in cases of unexplained fractures than rare disorders such as osteogenesis imperfecta (OI), ruling out OI and other medical causes of fracture is always indicated. The majority of OI patients can be diagnosed with the help of family history, physical examination, and radiographic findings. In particular, there are a few radiological findings which are seen more commonly in NAI than in OI which may help guide clinician considerations regarding the probability of either of these diagnoses. At the same time, molecular testing still merits careful consideration in cases with unexplained fractures without obvious additional signs of abuse. PMID:26492946

  19. Hematological Effects of Total or Partial Irradiation of the Human Body

    Many studies have been devoted to hematological effects of total body irradiation in various animal species, but there are few human data. In addition, the origin of these documents limited value. It is indeed, sometimes accidentally irradiated subjects, including irradiation was not uniform and that the dosimetry performed a posteriori, is random, sometimes irradiated patients or for the treatment of cancer or to suppress immunological reactions so that a transplant of tissue or an organ transplant, and one may wonder if the reactions such subjects are similar to those of normal subjects. Documents valid for partial irradiation of a human body by a single session even fewer and almost all relate to accidental irradiation

  20. Development of a dose assessment module in case of modeling of long range atmospheric transport of accidental releases from NPP

    The Bulgarian Emergency Response System (BERS) is in operation in the Bulgarian National Institute of Meteorology and Hydrology with Bulgarian Academy of sciences (NIMH-BAS) since 1995. BERS is based on numerical weather forecast and numerical long-range dispersion model accounting for the transport, dispersion, chemical and radioactive transformations of pollutants. The previous versions of this system were used and successfully tested during the ETEX experiments and a number of international and national exercises. In the present paper the further development of the system for calculation of a mixture of 31 radioactive gaseous and aerosol radioactive nuclides is described. The basic module of this system - the numerical dispersion model EMAP is upgraded with a 'dose calculation module' for estimation of the prognostic dose fields for the essential radionuclides from the calculated by EMAP concentration and deposition fields. Testing of the system is performed simulating hypothetical accidental atmospheric releases with real meteorology in real time from real NPPs situated in Europe based on emission scenarios created for the basic reactor types being into operation in Europe. The effective doses from external irradiation, from air submersion and ground shinning, effective dose from inhalation and absorbed thyroid dose formed by the different radionuclides, significant for the early stage of a nuclear accident, are calculated as dose fields in the different case studies. The presented study is an important step in the development of the BERS by producing decision-ready output directed to enhancing the Bulgarian emergency preparedness in case of accidental releases. (author)

  1. The Effects of Localisation Decisions on New Product Superiority and Performance: Empirical Research on Consumer-Goods Subsidiaries

    Firmanzah

    2009-06-01

    Full Text Available New products, while essential, are risky and expensive for subsidiaries. The main objective of this research is to determine success factors for new product launch (NPL by subsidiaries operating in developing countries. It is argued that localisation of NPL decisions contributes positively to new product superiority and commercial performance, with partial least squares used to test the hypothesis. The results show that localisation of innovation decisions increases localisation of branding and commercialisation decisions in the local market. However, localisation of commercialisation decisions positively influences new product superiority, while localisation of innovation decisions reduces this superiority. Finally, hypothesis testing reveals that localisation of commercial decisions and new product superiority both increase the commercial performance of new products in the local market.

  2. Determination of reduction in life expectancy from stochastic somatic fatalities after accidental radiation exposure

    In risk studies for plants of the nuclear industry usually the number of fatalities by radiation induced health effects are assessed. They are divided into 'early fatalities' (mortality by acute radiation syndrom) and 'late fatalities' (deaths due to leukemia and cancer). For the individuals as well as for the society as a whole both health effects are in principle of different significance because of the different times of death after irradiation. Risk assessments which give only the number of fatalities therefore show an uncomplete picture of the consequence because they do not consider the age of the individuals at the time of death. In this report the mathematical models for the computation of the individual and collective reduction of life expectancy from stochastic somatic effects after accidental releases of radioactivity are described. Computational results with regard to the age distribution of the population are presented for persons living during the nuclear accident and persons born afterwards. Thereby the exposure pathways, organs and nuclides ot the German Risk Study are treated separately. A raw estimation of the reduction in life expectancy due to the late fatalities calculated in this study is given. (orig.)

  3. Methodology and practical basis for emergency planning in case of accidental releases

    Statistical methods are used to anticipate offsite consequences resulting from an accidental release of radioactivity into the atmosphere for the 1-100 km range. This approach is very useful for safety purposes, for example to select nuclear sites; but it cannot be used for emergency preparedness plans. The preparation of emergency plans must be dependent upon the type of nuclear facility and site characteristics, and should take into account the conditions pertaining to the time of application (e.g. weather). In other words, the preparation of an emergency situation depends upon all the specific characteristics of each site. The plan has to be established considering a wide range of accidents which could occur at the site, including those with a very low probability of occurrence. Furthermore, emergency countermeasures have to be provided for in view of the radiological risk to individual members of the public. This implies calculation of the ''projected'' dose due to external irradiation (plume and deposits) and inhalation (plume and resuspension of deposits). Calculations are based on the use of an atmospheric transfer model as simple and as realistic as possible so that it can cover a wide range of situations. A description of the model used by the French Institute of Protection and Nuclear Safety is given, together with an appropriate example

  4. Evaluation of accidental acute irradiated persons with respect to therapeutic measures

    Appropriate therapy of patients suffering radiation accident depends on the extent and type of the injury. Usually bone marrow syndromes are treated first. Therefore, it is very important to determine haemopoietic tissue damages as early as possible. 589 patients from 22 acute radiation accidents were examined from pathophysiology and radiation biology points of view. Various diagnostic and evaluation methods are presented and analyzed. (N.T.) 21 refs.; 3 figs.; 3 tabs

  5. The comparison of doses and risks from radon, medical and accidental irradiation

    The following radiation hazards to the population of the region of Sverdlovsk are compared: the hazard from the exposure to indoor radon in dwellings; the consequences of the radiation accident at the 'Mayak' nuclear power plant in 1957; radioactive contamination by thorium enrichment tails; medical diagnostic exposure. It is concluded that radon and its daughters constitute the most significant radiation hazard. (A.K.)

  6. Biological dose estimation for accidental supra-high dose gamma-ray exposure

    Chen, Y., E-mail: yingchen29@yahoo.com.cn [Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing 100850 (China); Yan, X.K. [Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing 100850 (China); Department of Radiation Safety, Beijing Institute of Nuclear and Chemical Safety, 14 Guan-cun, Dongcheng District, Beijing 100077 (China); Du, J.; Wang, Z.D.; Zhang, X.Q.; Zeng, F.G.; Zhou, P.K. [Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing 100850 (China)

    2011-09-15

    To correctly estimate the biological dose of victims accidentally exposed to a very high dose of {sup 60}Co gamma-ray, a new dose-effect curve of chromosomal dicentrics/multicentrics and rings in the supra-high dose range was established. Peripheral blood from two healthy men was irradiated in vitro with doses of {sup 60}Co gamma-rays ranging from 6 to 22 Gy at a dose rate of 2.0 Gy/min. Lymphocytes were concentrated, cultured and harvested at 52 h, 68 h and 72 h. The numbers of dic + r were counted. The dose-effect curves were established and validated using comparisons with doses from the Tokai-mura accident and were then applied to two victims of supra-high dose exposure accident. The results indicated that there were no significant differences in chromosome aberration frequency among the different culture times from 52 h to 72 h. The 6-22 Gy dose-effect curve was fitted to a linear quadratic model Y = -2.269 + 0.776D - 7.868 x l0{sup -3}D{sup 2}. Using this mathematic model, the dose estimates were similar to data from Tokai-mura which were estimated by PCC ring. Whole body average doses of 9.7 Gy and 18.1 Gy for two victims in the Jining accident were satisfactorily given. We established and successfully applied a new dose-effect curve of chromosomal dicentrics plus ring (dic + r) after 6-22 Gy {gamma}-irradiation from a supra-high dose {sup 60}Co gamma-ray accident.

  7. Two oppositely localised frizzled RNAs as axis determinants in a cnidarian embryo.

    Tsuyoshi Momose

    2007-04-01

    Full Text Available In phylogenetically diverse animals, including the basally diverging cnidarians, "determinants" localised within the egg are responsible for directing development of the embryonic body plan. Many such determinants are known to regulate the Wnt signalling pathway, leading to regionalised stabilisation of the transcriptional coregulator beta-catenin; however, the only strong molecular candidate for a Wnt-activating determinant identified to date is the ligand Wnt11 in Xenopus. We have identified embryonic "oral-aboral" axis determinants in the cnidarian Clytia hemisphaerica in the form of RNAs encoding two Frizzled family Wnt receptors, localised at opposite poles of the egg. Morpholino-mediated inhibition of translation showed that CheFz1, localised at the animal pole, activates the canonical Wnt pathway, promotes oral fates including gastrulation, and may also mediate global polarity in the ectoderm. CheFz3, whose RNA is localised at the egg vegetal cortex, was found to oppose CheFz1 function and to define an aboral territory. Active downregulation mechanisms maintained the reciprocal localisation domains of the two RNAs during early development. Importantly, ectopic expression of either CheFz1 or CheFz3 was able to redirect axis development. These findings identify Frizzled RNAs as axis determinants in Clytia, and have implications for the evolution of embryonic patterning mechanisms, notably that diverse Wnt pathway regulators have been adopted to initiate asymmetric Wnt pathway activation.

  8. Somatostatin receptor scintigraphy and intraoperative gamma probe detection in the localisation and treatment of pancreatic insulinoma

    Full text: Aims: We report a case of insulinoma that was successfully enucleated under radio-guidance after an initial unsuccessful laparotomy. This case highlights the utility of Somatostatin Receptor Scintigraphy (SRS) and gamma probe in the localisation and treatment of neuroendocrine tumours. Methods: The patient presented with recurrent hypoglycaemia. An abdominal CT scan identified a lesion in the uncinate process of the pancreas, however, laparotomy with use of intraoperative ultrasound failed to localise the lesion. SRS with SPECTICT was then requested by the surgical team with a view to radio-guided surgery. Results: SRS demonstrated an octreotide-avid tumour in the posterior uncinate process of the pancreas, and confirmed suitability for radio-guided surgery. At re-exploration, the surgeon was again unable to palpate the lesion or localise it with intraoperative ultrasound, however, the lesion was successfully detected and removed with the use of a gamma probe. A postoperative SRS confirmed complete excision and histopathology was diagnostic of insulinoma. Conclusion: This case highlights the utility of SRS in the intraoperative localisation and surgical excision of neuroendocrine tumours. The lesion was unable to be localised clinically or with intraoperative ultrasound but was successfully detected with scintigraphic techniques. The surgical team acknowledge that the use of a gamma probe enabled enucleation of the insulinoma, which obviated the need for an invasive Whipple's procedure.

  9. Two new tools and a working method for crisis management of accidental spills at sea. Doctoral thesis

    Koops, W.

    1992-12-14

    Tables of Contents: Accidental spills and crisis management at sea; Present global situation concerning prevention of accidental spills; Present regional situation concerning preparation for accidental spills in the North Sea; Present national (Dutch) situation concerning response to accidental spills; Improvements in present crisis management approach; Design of the gravity scale for accidental spills; Introduction and design of a diagnostic model for accidental spills at sea; Introduction and design of a working method to support decision making in response situations; The computer program; Calibration and evaluation of the newly developed tools and working method; and, Appendices with background information.

  10. Procedures, placement, and risks of further abuse after Munchausen syndrome by proxy, non-accidental poisoning, and non-accidental suffocation

    Davis, P.; McClure, R; Rolfe, K; Chessman, N; Pearson, S.; Sibert, J; Meadow, R

    1998-01-01

    OBJECTIVES—To investigate outcome, management, and prevention in Munchausen syndrome by proxy, non-accidental poisoning, and non-accidental suffocation.
DESIGN—Ascertainment through British Paediatric Surveillance Unit and questionnaires to responding paediatricians.
SETTING—The UK and Republic of Ireland, September 1992 to August 1994.
SUBJECTS—Children under 14 years diagnosed with the above.
MAIN OUTCOME MEASURES—Placement and child protection measures for victims and sib...

  11. Accidental staggered paracetamol overdose: An interesting case report

    Kanakkande Aabideen

    2011-01-01

    Full Text Available Paracetamol is one of the most commonly used drugs both over the counter and on prescription. Liquid paracetamol is available over the counter all over the world. Most commonly available concentrations are 120 mg/5 ml and 250 mg/5 ml. Many parents and healthcare professionals assume that doses available in different countries are similar. However, 500 mg/5 ml bottle is available in some countries including the United Kingdom. This leaves a potential for accidental overdose with therapeutic intent. We have reviewed the experience of diagnosing and managing an interesting case of paracetamol over dosage caused by several ingestions over 24 hours period (staggered paracetamol over dosage. It highlights the importance of communication between health professionals and parents while managing common medical problems.

  12. Nodular goiter after occupational accidental exposure to radiation

    Pisarev, M.A. [Radiobiology, National Atomic Energy Commission, Buenos Aires (Argentina); Human Biochemistry, Uninversity of Buenos Aires, School of Medicine, Buenos Aires (Argentina); Schnitman, M. [Center of Endocrinology and Metabolism, French Hospital C.Milstein, Buenos Aires (Argentina)

    2012-07-01

    In the present paper we present the consequences of an accidental occupational radiation exposure at a local hospital in Buenos Aires. Control at a local radiology service showed the lack of correct shielding in the X-ray equipment. The physicians and technicians (14 persons) exposed to radiation during 12 months were examined. The survey shows that: a) In 11 out of 14 radiation-exposed patients nodular goiter developed and an additional patient had diffuse goiter which means a goiter incidence of 85.7%; b) In 5 of the nodular goiter patients an increase in the size or the appearance of new nodules was observed along the follow-up period. No cancer was detected by FNA; c) Hypothyroidism was observed in 3/14 patients, and an additional patient had an abnormal TRH-TSH test, suggesting subclinical hypothyroidism; and d) Increased circulating antithyroid antibodies were found in one of the hypothyroid patients

  13. Siquieros accidental painting technique: a fluid mechanics point of view

    Zetina, Sandra

    2012-01-01

    This is an entry for the Gallery of Fluid Motion of the 65th Annual Meeting of the APS-DFD (fluid dynamics video). This video shows an analysis of the 'accidental painting' technique developed by D.A. Siqueiros, a famous Mexican muralist. We reproduced the technique that he used: pouring layers of paint of different colors on top of each other. We found that the layers mix, creating aesthetically pleasing patterns, as a result of a Rayleigh-Taylor instability. Due to the pigments used to give paints their color, they can have different densities. When poured on top of each other, if the top layer is denser than the lower one, the viscous gravity current undergoes unstable as it spread radially. We photograph the process and produced slowed-down video to visualize the process.

  14. Dose assessment of an accidental exposure at the IPNS

    Seven different methods were used to estimate the dose rate to a female worker who was accidentally exposed in the neutron PHOENIX beamline at the IPNS. Theoretical and measured entrance dose ranged from 550 mrem/min to 2850 mrem/min. Theoretical estimates were based on a Monte Carlo simulation of a spectrum provided by IPNS (Crawford Spectrum). Dose measurements were made with TLDs on phantoms and with ionization chambers in a water phantom. Estimates of the whole body total effective dose equivalent (TEDE) rate ranged from 5.2 mrem/min to 840 mrem/min. Assumed and measured quality factors ranged from 2.6 to 11.8. Cytogenetic analyses of blood samples detected no positive exposure. The recommended TEDE rate was 158 mrem/min. The TEDE was 750 mrem

  15. Accidental intrathecal injection of magnesium sulfate for cesarean section

    Mehryar Taghavi Gilani

    2014-01-01

    Full Text Available Magnesium sulfate is used frequently in the operation room and risks of wrong injection should be considered. A woman with history of pseudocholinesterase enzyme deficiency in the previous surgery was referred for cesarean operation. Magnesium sulfate of 700 mg (3.5 ml of 20% solution was accidentally administered in the subarachnoid space. First, the patient had warm sensation and cutaneous anesthesia, but due to deep tissue pain, general anesthesia was induced by thiopental and atracurium. After the surgery, muscle relaxation and lethargy remained. At 8-10 h later, muscle strength improved and train of four (TOF reached over 0.85, and then the endotracheal tube was removed. The patient was evaluated during the hospital stay and on the anesthesia clinic. No neurological symptoms, headache or backache were reported. Due to availability of magnesium sulfate, we should be careful for inadvertent intravenous, spinal and epidural injection; therefore before injection must be double checked.

  16. Notas sobre Accidentes Aéreos causados por Aves

    Oscar Rivera

    2009-06-01

    Full Text Available En varios artículos de opinión publicados en Engormix, el autor se ha referido a dos épocas muy peligrosas para la presentación de accidentes aéreos en diferentes países, situados especialmente en el hemisferio norte (Boreal. Comprenden dos etapas, la primera, en los meses de Septiembre y Octubre, cuando comienza el invierno en el Ártico que deja a millones de aves sin alimento, razón por la cual inician la migración a los diferentes continentes en busca de alimentos; la segunda, durante los meses de Febrero y Marzo, cuando emprenden su regreso al sitio de partida, coincidiendo con la iniciación de la primavera que les garantiza comida suficiente...

  17. Accidental intraoral formalin injection: a rare case report

    Ramakant Dandriyal

    2014-12-01

    Full Text Available Formalin is a hazardous chemical that needs cautious handling and special storage. Owing to its disinfectant and fixative (i.e. for preserving pathologic tissue specimens in histopathology properties, it is widely used in dentistry. Although, the terms formaldehyde and formalin are often confused as being identical, these are different as to the concentrations of the primary component i.e. formaldehyde. In fact, the common fixative available as 10% neutral buffered formalin is actually a 4% solution of formaldehyde (i.e., a 10% solution made from a 37-40% commercially pure formaldehyde solution. This case report describes an unfortunate case of accidental injection instead of local anesthetic, of formalin into the pterygomandibular space in a 35-year old woman during inferior alveolar nerve block for surgical removal of impacted lower right third molar and its successful management by cautious debridement (under both local and general anesthesia and empirical drug therapy (utilizing analgesics and antibiotics.

  18. Interest of stable iodine prophylaxis in accidental situation

    In the case of an accident on a nuclear reactor, radioactive substances could be released in atmosphere. among these substances, the presence of radioactive isotopes of iodine is a constant, that, in the lack of efficient counter measures could lead to an internal contamination, principally by inhalation but also by contaminated food ingestion. The radioactive iodine accumulate in the thyroid, leading to an exposure that at term can induce an increase of a cancer risk for this gland among the most sensitive persons, especially the children. It exists a simple and efficient protection mean: the taking of a tablet of stable iodine. In this article, the interest of the prophylaxis by stable iodine in accidental situation is tackled under the shape of eleven independent questions/answers, allowing a reading in several times but also the research of response elements to a question that the reader could wonder. (N.C.)

  19. Control of radiation sources and general regulations for accidental situations

    In order to prevent accidents caused by application of radiation sources the Tunisian O.N.P.C. established straightforward strategy made up of 3 phases: prevention, planning and intervention. Civil Protection conducts prevention studies of all radiation sources by examining normal application conditions as well as possible accidental situations. It keeps up with scientific, technical and statistical aspects of radiation risks, elaborates specific plans and programs for intervention operations and cooperates with administrative and security services as well as international organisations. The O.N.P.C. established a model intervention plan based on observation (according to preliminary information), evaluation of the situation (according to the head of operation) intervention (specialized units) and post intervention (testing of personnel)

  20. Accidentes en plantas nucleares de electricidad y el riesgo de cáncer

    Hoja informativa acerca de los riesgos del cáncer asociados con accidentes en plantas nucleares de electricidad. Incluye información para pacientes con cáncer que viven en una zona que puede haber sido afectada por un accidente en una planta nuclear.

  1. Two Cases of Accidental Injection of Epinephrine into a Digit Treated with Subcutaneous Phentolamine Injections

    Ryan P. Bodkin

    2013-01-01

    Full Text Available Accidental injection into the digit from an epinephrine autoinjection device can cause discoloration, pain, and paresthesias. Although loss of digit is rare, treatment in the emergency department is commonly aimed at vasodilation of the affected tissue. We report two cases of accidental injection of epinephrine into the digits that were successfully treated with subcutaneous phentolamine injection with no adverse events.

  2. Two Cases of Accidental Injection of Epinephrine into a Digit Treated with Subcutaneous Phentolamine Injections

    Bodkin, Ryan P.; Acquisto, Nicole M.; Wiegand, Timothy J.

    2013-01-01

    Accidental injection into the digit from an epinephrine autoinjection device can cause discoloration, pain, and paresthesias. Although loss of digit is rare, treatment in the emergency department is commonly aimed at vasodilation of the affected tissue. We report two cases of accidental injection of epinephrine into the digits that were successfully treated with subcutaneous phentolamine injection with no adverse events. PMID:24024046

  3. Performance test of a portable TLD system for accidental doses

    Full text: A portable TLD measuring system was constructed at the J. Stefan Institute many years ago, motivated by the thread of a catastrophic nuclear event. It was designed for fast measurements in accidental dosimetry mainly for military and civil protection use. The system consists of a robust portable measuring unit built for measurements in field conditions, sized about 40 cm in diameter and weighting 5 kg. Dosimeters are based on CaF2:Mn ceramic tablets closed in water resistant plastic housings. In original design producer assured measuring range from cGy to kGy. Specially designed energy compensating filters are used to satisfy requirements for energy response from 0,1 to 3 MeV. Stability of readings is maintained with the temperature stabilized light source. Measuring time for manually driven heating-reading cycle of one dosimeter is about 30 sec. Many systems of the type with sets of dosimeters were stored unused for some years in depositories of different institutions. Modernization of equipment in last years raised questions of applicability of such measurement systems for contemporary needs. The system was thus tested in a secondary standards dosimetry laboratory for compliance with up to date requirements for accidental individual monitoring. Dosimeter characteristics as repeatability, linearity and directional response were of particular interest. As a result of the tests, technical improvements are suggested to extent systems measuring capabilities in order to meet new standards. Possibilities of its use in different fields of dosimetry are discussed, where quick in field measurements of high doses is required as for example in medicine or in civil protection motivated by the new threads of terrorist attacks. (author)

  4. Accidental contamination with 90Sr: a case study

    A case of accidental inhalation and extensive contamination by 90Sr was observed in November 1995 in two workers who were handling a defective waste container with an old source of 90Sr used for lightning rods. An internal monitoring programme was established to obtain experimental excretion data from each worker. Urine bioassays were carried out and activities of 90Sr were determined from analyses of excreta by the liquid scintillation technique. The results were evaluated in accordance with ICRP recommendations using the dosimetric code GENMOD-PC. Since no information was available concerning aerosol size nor compound of the radionuclide, estimations of intakes were made following ICRP 30 recommendations, and an AMAD of 1 μm was assumed for the inhaled radioactive aerosol supposedly containing strontium titanate. The ICRP 30 theoretical excretion curve did not agree with the experimental data. Confirming that the source contained SrTiO3, the assumed 1 μm particle size of the aerosol accidentally inhaled had to be changed to 10 μm, in order to adjust the urinary excretion function to the measured values. The initial estimation for one of the exposed workers, assuming a 1 μm particle size, resulted in a 90Sr intake of 5 ALIs. The final intake estimations were made with the following assumptions: acute inhalation 24 November 1995, AMAD = 10 μm, Class Y solubility and ICRP 30 Respiratory Tract Model for Standard Man. The 90Sr estimated intake was 2.6 x 105 Bq (37% ALI) for one of the workers and 6.6 x 104 Bq (10% ALI) for the other. The committed whole-body effective dose equivalents were 19 mSv and 5 mSv respectively, and the dose equivalents to lung were 147 mSv and 37 mSv, respectively. (author)

  5. Management options in the food chain for accidental radionuclide deposition

    Finland with four other countries participated in the European Union's network project FARMING in 2000 - 2004. The aim of the project was to invite participants from each country representing the food supply chain in a stakeholder group and advance with the groups the networking in building preparedness for accidental contamination of the food production systems. The task of the groups was to evaluate the practicability of management options suggested for reduction of radiation exposure through foodstuffs, and for disposal of waste generated in implementation of these options. The criteria for practicability were effectiveness in reduction of radiation exposure through foodstuffs, technical feasibility, capacity, costs for implementation, secondary costs for waste disposal, socio-economic impact, and acceptability concerning ecology and protection of environment and landscape. Practicable management options aimed at sustainable restoration of food production systems after accidental contamination. The Finnish stakeholder group represented farm production, processing industry, food marketing, catering, advisor organisations for households and agriculture, consumers, nature conservation, the media, experts on environmental impact and authorities responsible for production, safety and security of foodstuffs, food supply and feedstuffs. The group was expected to examine the effect of the Finnish, and, also more generally, northern production conditions on the practicability of the suggested management options. The stakeholder group members first familiarized themselves with intervention after accidental contamination of a large milk production area and thereafter with practicability of individual management options. The evaluation was based on the group members' complementary expertise that very well covered the chain 'from field to fork' whether the issue was related to legislation, production methods, logistics, environmental impacts, or the issues of consumers and

  6. Evolution of glycaemia during irradiation syndrome; Evolution de la glycemie au cours du syndrome d'irradiation

    Raisonnier, A. [Commissariat a l' Energie Atomique, Fontenay aux Roses (France). Centre d' Etudes Nucleaires

    1967-03-15

    The evolution of glycaemia following irradiation has been followed in the rat and pig. The results concerning a case of human accidental exposure have also been included. The author has tried to see whether the observed variations are reproducible and have a prognostic value. (author) [French] L'evolution de la glycemie a ete suivie, chez le rat et le porc, apres irradiation. Les resultats relatifs a une irradiation accidentelle humaine sont egalement rapportes. L'auteur cherche a definir si les variations observees sont reproductibles et ont une valeur pronostique. (auteur)

  7. Divergent RNA Localisation Patterns of Maternal Genes Regulating Embryonic Patterning in the Butterfly Pararge aegeria.

    Jean-Michel Carter

    Full Text Available The maternal effect genes responsible for patterning the embryo along the antero-posterior (AP axis are broadly conserved in insects. The precise function of these maternal effect genes is the result of the localisation of their mRNA in the oocyte. The main developmental mechanisms involved have been elucidated in Drosophila melanogaster, but recent studies have shown that other insect orders often diverge in RNA localisation patterns. A recent study has shown that in the butterfly Pararge aegeria the distinction between blastodermal embryonic (i.e. germ band and extra-embryonic tissue (i.e. serosa is already specified in the oocyte during oogenesis in the ovariole, long before blastoderm cellularisation. To examine the extent by which a female butterfly specifies and patterns the AP axis within the region fated to be the germ band, and whether she specifies a germ plasm, we performed in situ hybridisation experiments on oocytes in P. aegeria ovarioles and on early embryos. RNA localisation of the following key maternal effect genes were investigated: caudal (cad, orthodenticle (otd, hunchback (hb and four nanos (nos paralogs, as well as TDRD7 a gene containing a key functional domain (OST-HTH/LOTUS shared with oskar. TDRD7 was mainly confined to the follicle cells, whilst hb was exclusively zygotically transcribed. RNA of some of the nos paralogs, otd and cad revealed complex localisation patterns within the cortical region prefiguring the germ band (i.e. germ cortex. Rather interestingly, otd was localised within and outside the anterior of the germ cortex. Transcripts of nos-O formed a distinct granular ring in the middle of the germ cortex possibly prefiguring the region where germline stem cells form. These butterfly RNA localisation patterns are highly divergent with respect to other insects, highlighting the diverse ways in which different insect orders maternally regulate early embryogenesis of their offspring.

  8. Association between PSA kinetics and cancer-specific mortality in patients with localised prostate cancer

    Thomsen, F B; Brasso, K; Berg, K D;

    2016-01-01

    with localised PCa managed on watchful waiting. PATIENTS AND METHODS: Patients with clinically localised PCa managed observationally, who were randomised to and remained on placebo for minimum 18 months in the SPCG-6 study, were included. All patients survived at least 2 years and had a minimum of...... three PSA determinations available. The prognostic value of PSA kinetics was analysed and patients were stratified according to their PSA at consent: ≤10, 10.1-25, and >25 ng/ml. Cumulative incidences of PCa-specific mortality were estimated with the Aalen-Johansen method. RESULTS: Two hundred and sixty...

  9. A comparative evaluation of CAT tools during the localisation of HTML5 files

    Castro Hernandez, Laura

    2015-01-01

    The new version of HTML5 introduced in 2014 includes ten new structural elements. The aim of this research project is to discover whether CAT tools are prepared to localise HTML5 or not, and to determine which of the two tools studied, MemoQ 2013 and SDL Trados Studio 2014, is the most suitable when localising a HTML5 website with HTML5 new structural elements. With this purpose, an experiment was designed and implemented at the University of Geneva (UNIGE). Fourteen students of the Faculty o...

  10. An evaluation of focal therapy in the treatment of localised prostate cancer

    Ahmed, H. U.

    2014-01-01

    In this doctoral thesis I am proposing a paradigm shift in the management of men with localised prostate cancer involving destroying areas of prostate cancer alone – so-called focal therapy. By doing so, I propose that side-effects of whole-gland therapies will be reduced whilst maintaining cancer control. I have carried out a phased and structured programme of work to test this hypothesis. First, I review the literature to define the current problem faced by men with localised prostate cance...

  11. Strain localisation in mechanically layered rocks beneath detachment zones: insights from numerical modelling

    L. Le Pourhiet

    2013-04-01

    Full Text Available We have designed a series of fully dynamic numerical simulations aimed at assessing how the orientation of mechanical layering in rocks controls the orientation of shear bands and the depth of penetration of strain in the footwall of detachment zones. Two parametric studies are presented. In the first one, the influence of stratification orientation on the occurrence and mode of strain localisation is tested by varying initial dip of inherited layering in the footwall with regard to the orientation of simple shear applied at the rigid boundary simulating a rigid hanging wall, all scaling and rheological parameter kept constant. It appears that when Mohr–Coulomb plasticity is being used, shear bands are found to localise only when the layering is being stretched. This corresponds to early deformational stages for inital layering dipping in the same direction as the shear is applied, and to later stages for intial layering dipping towards the opposite direction of shear. In all the cases, localisation of the strain after only γ=1 requires plastic yielding to be activated in the strong layer. The second parametric study shows that results are length-scale independent and that orientation of shear bands is not sensitive to the viscosity contrast or the strain rate. However, decreasing or increasing strain rate is shown to reduce the capacity of the shear zone to localise strain. In the later case, the strain pattern resembles a mylonitic band but the rheology is shown to be effectively linear. Based on the results, a conceptual model for strain localisation under detachment faults is presented. In the early stages, strain localisation occurs at slow rates by viscous shear instabilities but as the layered media is exhumed, the temperature drops and the strong layers start yielding plastically, forming shear bands and localising strain at the top of the shear zone. Once strain localisation has occured, the deformation in the shear band becomes

  12. Localised sarcoptic mange in dogs: a retrospective study of 10 cases.

    Pin, D; Bensignor, E; Carlotti, D-N; Cadiergues, M C

    2006-10-01

    The authors report 10 cases of localised sarcoptic mange in dogs. In each case, lesions were localised to one precise area of the skin. Pruritus was present in nine cases and absent in one. Affected areas were the feet (one case), the face and/or the pinnae (six cases), the abdominal skin (one case), the flank (one case) and the lumbar area (one case). The types of lesions were erythema, papules, lichenification, scales, crusts and alopecia. Parasites were found in all cases except one, in which anti-immunoglobulin G Sarcoptes serology was positive. The acaricidal treatments given were lindane, ivermectin or selamectin and were all successful. PMID:17004955

  13. Characterization and Comparison of Injuries Caused by Accidental and Non-accidental Blunt Force Trauma in Dogs and Cats.

    Intarapanich, Nida P; McCobb, Emily C; Reisman, Robert W; Rozanski, Elizabeth A; Intarapanich, Pichai P

    2016-07-01

    Motor vehicle accidents (MVA) are often difficult to distinguish from non-accidental injury (NAI). This retrospective case-control study compared animals with known MVA trauma against those with known NAI. Medical records of 426 dogs and cats treated after MVA and 50 after NAI were evaluated. Injuries significantly associated with MVA were pelvic fractures, pneumothorax, pulmonary contusion, abrasions, and degloving wounds. Injuries associated with NAI were fractures of the skull, teeth, vertebrae, and ribs, scleral hemorrhage, damage to claws, and evidence of older fractures. Odds ratios are reported for these injuries. MVA rib fractures were found to occur in clusters on one side of the body, with cranial ribs more likely to fracture, while NAI rib fractures were found to occur bilaterally with no cranial-caudal pattern. Establishing evidence-based patterns of injury may help clinicians differentiate causes of trauma and may aid in the documentation and prosecution of animal abuse. PMID:27364279

  14. EPR Dosimetry in Irradiated Fingernails

    The Electron Paramagnetic Resonance (EPR) is being transformed in a complementary tool of biologically-based methods for evaluation of dose after accidental radiation exposure. Many efforts are being carried out in laboratories to evaluate the performance of different materials for its use in EPR doses measurements and for improving the current methods for spectrum analysis and calibration curves determinations. In our country the EPR techniques have been used in different areas with dosimetric (alanine) and non dosimetric purposes. Now we are performing the first studies to obtain properly dose response curves to be used for accidental dose assessments through irradiated fingernails. It is by now well known that the fingernails present two types of signals, a background one (BKS), originated in elastic and inelastic mechanical deformations and the radio induced one (RIS), object of interest (I). In this work we will present some of the previous studies performed to characterize the fingernail samples and we analyse the additive dose method for data obtained employing the technique of the substraction of the spectrum recorded at two different microwave powers in order to reduce the BKS signal. Fingernail samples collected from different donors were treated by soaking in water during 10 min and 5 min drying on paper towel and the BKS signals were studied previously its irradiation. The statistical analysis (R statistics) show a distribution with a Standard Deviation of 24% respects to its media. During these studies we also conserved in freezer for more than 6 months irradiated fingernails that, were periodically measured and the statistical analysis of the peak to peak amplitude show a normal distribution through the Quantile correlation test with a SD 11% respected to its median. (authors)

  15. Extrinsic Defects in UV-irradiated MgO Single Crystal Detected by Thermoluminescence

    D. Kadri; S. Hiadsi; Hamzaoui, S.

    2007-01-01

    MgO single crystal sample previously irradiated with ultraviolet light (UV) 4.8 eV has been studied using thermoluminescence (TL) technique in the temperature range 170-500�K, in this study, we were mainly interested in the extrinsic defects (impurities), these impurities are localised in four distinct regions, Cr3+ is assigned to the first region 680-760 nm, in the second region 465-500 nm we find Ni2+, Fe3+ is localised in the third region 310-375 nm and lastly the Ca2+ and K+ have been fou...

  16. Extrinsic Defects in UV-irradiated MgO Single Crystal Detected by Thermoluminescence

    D. Kadri

    2007-01-01

    Full Text Available MgO single crystal sample previously irradiated with ultraviolet light (UV 4.8 eV has been studied using thermoluminescence (TL technique in the temperature range 170-500�K, in this study, we were mainly interested in the extrinsic defects (impurities, these impurities are localised in four distinct regions, Cr3+ is assigned to the first region 680-760 nm, in the second region 465-500 nm we find Ni2+, Fe3+ is localised in the third region 310-375 nm and lastly the Ca2+ and K+ have been found to emit in the 180-260 nm region.

  17. Factores de riesgo asociados a los accidentes en el hogar

    Lidia Arlaes Yero

    1998-12-01

    Full Text Available Se realizó un estudio analítico retrospectivo (caso-control sobre accidentes en el hogar ocurridos en la población de dos consultorios de médicos de familia del área centro en el municipio Sancti Spiritus, durante el año 1996. Se tuvo en cuenta la ocurrencia de estos eventos en la población general, la incidencia estuvo representada por 77 casos y se escogió como grupo control el resto de la población. Como resultado se observó que los accidentes del hogar (AH son más frecuentes en mujeres en edades avanzadas, con una distribución temporal mayor en el cuarto trimestre del año. Los AH fueron más frecuentes en los individuos que ingieren psicofármacos en las edades extremas de la vejez. El horario de ocurrencia más frecuente fue el de la tarde; y los lugares, la cocina y el patio. Como tipo de lesión predominó la contusión y la herida. Se concluyó además que la presencia de factores predisponentes constituyen riesgo de gran magnitud en la aparición de los AHAn analytical retrospective study (case-control about home accidents occurred among the population of 2 family physician’s offices in the central area of the municipality of Sancti Spiritus, during 1996, was conducted. The occurrence of such events in the general population was taken into account. Incidence was represented by 77 cases and the rest of the population was chosen as a control group. As a result, it was observed that home accidents were more frequent in aged women, with a greater temporary distribution in the fourth trimester of the year. Home accidents took place more frequently in those individuals taking psychotropic drugs a extreme advanced ages. Most of the accidents occurred in the afternoon, and the kitchen and the backyard were the commonest places. Contusions and wounds were the predominant injuries. It was concluded that the presence of predisposing factors is a high risk for the occurrence of home accidents

  18. La prevención de accidentes (2

    Chinchilla, M.

    1966-03-01

    Full Text Available Everyone prefers to work in those organizations where their dignity of human beings is respected. One of the most efficient means at the disposal of any firm, to improve the morale of the individual employees, and to establish a spirit of cooperation between the individual and the firm, is to set up a program of accident benefit. It will avoid direct and indirect losses due to working accidents, as analyzed in a previous article, and it will make it possible to improve total performance of each worker, since he will work in a more favorable environment, free from worry about potential danger to his person. It is almost impossible to describe in detail all those items that should be taken into account in a safety program. None the less, and as an indication of their diversity, some sources of danger are mentioned in this chapter, which are closely connected with human safety, such as public curiosity, travelling from one place to another, cleanliness and order.Todas las personas prefieren desempeñar sus tareas en aquellas organizaciones que tienen hacia ellos las consideraciones correspondientes a un ser humano. Uno de los medios más eficaces a disposición de cualquier empresa para elevar la moral del individuo y para crear un lazo de cooperación común entre el individuo y la empresa, es la de llevar a cabo un programa de prevención de accidentes, programa que redundará en el doble fruto: evitar las pérdidas directas e indirectas causadas por los accidentes de trabajo que se detallaron en un trabajo anterior, y conseguir aumentar el rendimiento del operario al hacerle un ambiente más grato por la preocupación que se demuestra hacia su persona. Es casi imposible detallar todos aquellos puntos que se deben tener en cuenta en un programa de seguridad; sin embargo, y como exponente de su diversidad, se señalan en este capítulo algunas causas, que, sin estar ligadas directamente con el trabajo individual, no obstante se encuentran

  19. Detecting spatiotemporal clusters of accidental poisoning mortality among Texas counties, U.S., 1980 – 2001

    Harris Ann

    2004-10-01

    Full Text Available Abstract Background Accidental poisoning is one of the leading causes of injury in the United States, second only to motor vehicle accidents. According to the Centers for Disease Control and Prevention, the rates of accidental poisoning mortality have been increasing in the past fourteen years nationally. In Texas, mortality rates from accidental poisoning have mirrored national trends, increasing linearly from 1981 to 2001. The purpose of this study was to determine if there are spatiotemporal clusters of accidental poisoning mortality among Texas counties, and if so, whether there are variations in clustering and risk according to gender and race/ethnicity. The Spatial Scan Statistic in combination with GIS software was used to identify potential clusters between 1980 and 2001 among Texas counties, and Poisson regression was used to evaluate risk differences. Results Several significant (p Conclusion The findings of the present study provide evidence for the existence of accidental poisoning mortality clusters in Texas, demonstrate the persistence of these clusters into the present decade, and show the spatiotemporal variations in risk and clustering of accidental poisoning deaths by gender and race/ethnicity. By quantifying disparities in accidental poisoning mortality by place, time and person, this study demonstrates the utility of the spatial scan statistic combined with GIS and regression methods in identifying priority areas for public health planning and resource allocation.

  20. The Frequency of the Accidental Contamination with Laboratory Samples in Yazd Clinical Laboratories’ personnel in 2011

    Jafari, AA. (PhD

    2014-05-01

    Full Text Available Background and Objective: laboratory personnel have always accidental exposure to clinical samples, which can cause the transmission of infection. This threat can be prevented and controlled by education for the use of safety instruments. The purpose was to determine the frequency of accidental exposure to laboratory samples among Yazd laboratory personnel in 2011. Material and Methods: This descriptive cross-sectional study was conducted on 100 of Yazd clinical laboratory personnel. The data was collected, using a valid and reliable questioner, via interview and analyzed by means of SPSS software. Results: Eighty-six percent of the subjects reported an experience of accidental exposure to clinical samples, such as blood, serum and urine. The causes were carelessness (41% and work overload (29%. Needle- stick was the most prevalent injury (52% particularly in sampler workers (51% and in their hands (69%. There wasn’t significant relationship between accidental exposure to laboratory samples and the variables such as private and governmental laboratories (p=0.517, kind of employment (p=0.411, record of services (p=0.439 and academic degree (p=0.454. The subjects aged 20-29 (p=0.034 and worked in sampling unit had the highest accidental exposure. Conclusion: based on the results, inexperience of the personnel especially in sampling room, overload at work and ignorance of applying safety instruments are known as the most important reasons for accidental exposure to clinical samples. Keywords: Contamination; accidental Exposure; Infectious agents; laboratory; personnel

  1. Pinch and swell structures: evidence for strain localisation by brittle-viscous behaviour in the middle crust

    Gardner, R. L.; Piazolo, S.; Daczko, N. R.

    2015-09-01

    The flow properties of middle crustal rocks are commonly represented by viscous flow. Examples of pinch and swell structures found in a high strain zone at St. Anne Point (Fiordland, New Zealand) and Wongwibinda (N.S.W., Australia) suggest pinch and swell structures may be initiated by brittle failure of the more competent layer in conjunction with subsequent material softening. On this basis we develop a numerical model where Mohr-Coulomb constitutive strain localising behaviour is utilised to initiate pinch and swell structure development. Results show that pinch and swell structures develop in a competent layer in both Newtonian and non-Newtonian flow, provided the competent layer has sufficient viscosity contrast and can localise strain to form shear bands. The flow regime and strain localising characteristics of the surrounding country rock appear not to impact pinch and swell structure formation. The degree of material softening after the initial strain localising behaviour is shown to impact pinch and swell characteristics, while extensive material softening causes the formation of thick necks between swells by limiting the focused localisation of strain into shear bands. To aid analysis of the structures and help derive the flow properties of rocks in the field, we define three stages of pinch and swell development and offer suggestions for measurements to be made in the field. Our study suggests that Mohr-Coulomb strain localising behaviour combined with viscous flow is a viable alternative representation of the heterogeneous rheological behaviour of rocks seen in the middle crust. This type of mid-crustal rheological behaviour can have significant influence on the localisation of strain at all scales. For example, inclusion of Mohr-Coulomb strain localising behaviour with viscous flow in just some mid-crustal layers within a crustal-scale model can result in significant strain localisation, extending from the upper crust into the middle crust. This

  2. Aesthetic Proximity: the Role of Stylistic Programme Elements in Format Localisation

    van Keulen, Jolien

    2016-01-01

    abstractImplications of the transnationalisation of television are often studied by focusing on the localisation of the content of formatted programmes. Although television is essentially an audio-visual medium, little attention has been paid to the aesthetic aspects of television texts in relation

  3. Unprecedented spin localisation in a metal-metal bonded dirhenium complex

    Yan, Yong; Mague, Joel T.; Donahue, James; Sproules, Stephen

    2015-01-01

    he molecular and electronic structure of edge-sharing bioctahedral [N(n-Bu)4]3[Re2(mnt)5] is reported here. Despite the short intermetal bond length of 2.6654(2) Å with computed bond order of 1.2, the unpaired electron is localised by the asymmetric ligand distribution, as demonstrated by its remarkable EPR spectrum.

  4. Sestamibi scintigraphy for parathyroid localisation: a reminder of the dangers of false positives

    Whitcroft, Katherine Lisa; Sharma, Anup

    2014-01-01

    Surgical parathyroidectomy is the only curative treatment for primary hyperparathyroidism. As minimally invasive parathyroidectomy increases in popularity, so does reliance on preoperative parathyroid localisation techniques. One such technique is sestamibi scintigraphy. We report a case of false-positive sestamibi scintigraphy caused by follicular variant of papillary thyroid carcinoma. Subsequent completion thyroidectomy was not possible due to widespread postoperative fibrosis. This case, ...

  5. Organic molecules showing the characteristics of localised corrosion aggravation and inhibition

    Tan Yongjun, E-mail: yj.tan@curtin.edu.a [Department of Chemistry, Curtin University, GPO Box U1987, Perth (Australia); Mocerino, Mauro; Paterson, Tristan [Department of Chemistry, Curtin University, GPO Box U1987, Perth (Australia)

    2011-05-15

    Research highlights: {yields} Novel experiment for the discovery of localised corrosion inhibitors. {yields} New method of identifying inhibitors promoting random distribution of anodic currents. {yields} Discovery of resorcinarene acid as an effective localised corrosion inhibitor. - Abstract: The behaviour of imidazoline and an acid functionalised resorcinarene as steel corrosion inhibitors in carbon dioxide (CO{sub 2})-saturated brine solutions has been studied using an electrochemically integrated multi-electrode array namely the wire beam electrode (WBE). Both imidazoline and resorcinarene acid provided excellent inhibition to general CO{sub 2} corrosion; however imidazoline was found to aggravate localised corrosion by creating a small number of major anodes that focused on a small area of the WBE surface, leading to highly concentrated anodic dissolution. The resorcinarene acid showed distinctively different behaviour by generating a large number of minor anodes randomly distributing over the WBE surface, leading to insignificant general anodic dissolution. These results indicate that resorcinarene acid provided effective localised corrosion inhibition by promoting a random distribution of insignificant anodic currents.

  6. Immuno-localisation of anti-thyroid antibodies in adult human cerebral cortex.

    Moodley, Kogie; Botha, Julia; Raidoo, Deshandra Munsamy; Naidoo, Strinivasen

    2011-03-15

    Expression of thyroid-stimulating hormone receptor (TSH-R) has been demonstrated in adipocytes, lymphocytes, bone, kidney, heart, intestine and rat brain. Immuno-reactive TSH-R has been localised in rat brain and human embryonic cerebral cortex but not in adult human brain. We designed a pilot study to determine whether anti-thyroid auto-antibodies immuno-localise in normal adult human cerebral cortex. Forensic samples from the frontal, motor, sensory, occipital, cingulate and parieto-occipito-temporal association cortices were obtained from five individuals who had died of trauma. Although there were no head injuries, the prior psychiatric history of patients was unknown. The tissues were probed with commercial antibodies against both human TSH-R and human thyroglobulin (TG). Anti-TSH-R IgG immuno-localised to cell bodies and axons of large neurones in all 6 regions of all 5 brains. The intensity and percentage of neurones labelled were similar in all tissue sections. TSH-R immuno-label was also observed in vascular endothelial cells in the cingulate gyrus. Although also found in all 5 brains and all six cortical regions, TG localised exclusively in vascular smooth muscle cells and not on neurones. Although limited by the small sample size and number of brain areas examined, this is the first study describing the presence of antigenic targets for anti-TSH-R IgG on human cortical neurons, and anti-TG IgG in cerebral vasculature. PMID:21196016

  7. Localisation of Sensor Nodes with Hybrid Measurements in Wireless Sensor Networks

    Muhammad W. Khan

    2016-07-01

    Full Text Available Localisation in wireless networks faces challenges such as high levels of signal attenuation and unknown path-loss exponents, especially in urban environments. In response to these challenges, this paper proposes solutions to localisation problems in noisy environments. A new observation model for localisation of static nodes is developed based on hybrid measurements, namely angle of arrival and received signal strength data. An approach for localisation of sensor nodes is proposed as a weighted linear least squares algorithm. The unknown path-loss exponent associated with the received signal strength is estimated jointly with the coordinates of the sensor nodes via the generalised pattern search method. The algorithm’s performance validation is conducted both theoretically and by simulation. A theoretical mean square error expression is derived, followed by the derivation of the linear Cramer-Rao bound which serves as a benchmark for the proposed location estimators. Accurate results are demonstrated with 25%–30% improvement in estimation accuracy with a weighted linear least squares algorithm as compared to linear least squares solution.

  8. Growth patterns in Onychophora (velvet worms: lack of a localised posterior proliferation zone

    Landman Kerry A

    2010-11-01

    Full Text Available Abstract Background During embryonic development of segmented animals, body segments are thought to arise from the so-called "posterior growth zone" and the occurrence of this "zone" has been used to support the homology of segmentation between arthropods, annelids, and vertebrates. However, the term "posterior growth zone" is used ambiguously in the literature, mostly referring to a region of increased proliferation at the posterior end of the embryo. To determine whether such a localised posterior proliferation zone is an ancestral feature of Panarthropoda (Onychophora + Tardigrada + Arthropoda, we examined cell division patterns in embryos of Onychophora. Results Using in vivo incorporation of the DNA replication marker BrdU (5-bromo-2'-deoxyuridine and anti-phospho-histone H3 immunolabelling, we found that a localised posterior region of proliferating cells does not occur at any developmental stage in onychophoran embryos. This contrasts with a localised pattern of cell divisions at the posterior end of annelid embryos, which we used as a positive control. Based on our data, we present a mathematical model, which challenges the paradigm that a localised posterior proliferation zone is necessary for segment patterning in short germ developing arthropods. Conclusions Our findings suggest that a posterior proliferation zone was absent in the last common ancestor of Onychophora and Arthropoda. By comparing our data from Onychophora with those from annelids, arthropods, and chordates, we suggest that the occurrence of a "posterior growth zone" currently cannot be used to support the homology of segmentation between these three animal groups.

  9. How active ingredient localisation in plant tissues determines the targeted pest spectrum of different chemistries

    Buchholz, Anke; Trapp, Stefan

    2016-01-01

    information sets revealed that the intracellular localisation of active ingredients determines the performance of test compounds against different target pests because of different feeding behaviours: mites feed on mesophyll, and aphids and whiteflies mostly in the vascular system. Polar compounds have a slow...

  10. Globalisation and Localisation in Music Education in Hong Kong and Taiwan

    Ho, Wai-Chung

    2013-01-01

    The purpose of the study is to analyse and discuss the influences of globalisation and localisation on music education in Hong Kong and Taiwan. It argues that the reform of music education concerns changes to the contents of the curriculum that envisage the cultural and political developments that arise from processes of globalisation and…

  11. Semi-Classical Localisation Properties of Quantum Oscillators on a Noncommutative Configuration Space

    Benatti, Fabio; Gouba, Laure

    2015-11-01

    When dealing with the classical limit of two quantum mechanical oscillators on a noncommutative configuration space, the limits corresponding to the removal of configuration-space noncommutativity and position-momentum noncommutativity do not commute. We address this behaviour from the point of view of the phase-space localisation properties of the Wigner functions of coherent states under the two limits.

  12. Quantum resonance, Anderson localisation and selective rotational excitation in periodically kicked molecules

    Averbukh I. Sh.

    2013-03-01

    Full Text Available We show that molecules kicked periodically by laser pulses currently used in molecular alignment experiments allow to observe effects of the periodically kicked quantum rotor in a real rotational system. Among these effects are Anderson localisation in angular momentum and the scaling of the quantum resonance. Based on this, we propose a new scheme for selective molecular rotational excitation.

  13. Localisation of Sensor Nodes with Hybrid Measurements in Wireless Sensor Networks.

    Khan, Muhammad W; Salman, Naveed; Kemp, Andrew H; Mihaylova, Lyudmila

    2016-01-01

    Localisation in wireless networks faces challenges such as high levels of signal attenuation and unknown path-loss exponents, especially in urban environments. In response to these challenges, this paper proposes solutions to localisation problems in noisy environments. A new observation model for localisation of static nodes is developed based on hybrid measurements, namely angle of arrival and received signal strength data. An approach for localisation of sensor nodes is proposed as a weighted linear least squares algorithm. The unknown path-loss exponent associated with the received signal strength is estimated jointly with the coordinates of the sensor nodes via the generalised pattern search method. The algorithm's performance validation is conducted both theoretically and by simulation. A theoretical mean square error expression is derived, followed by the derivation of the linear Cramer-Rao bound which serves as a benchmark for the proposed location estimators. Accurate results are demonstrated with 25%-30% improvement in estimation accuracy with a weighted linear least squares algorithm as compared to linear least squares solution. PMID:27455268

  14. Localisation of brain functions : stimuling brain activity and source reconstruction for classification/

    Noirhomme, Quentin

    2006-01-01

    A key issue in understanding how the brain functions is the ability to correlate functional information with anatomical localisation. Functional information can be provided by a variety of techniques like positron emission tomography (PET), functional MRI (fMRI), electroencephalography (EEG), magnetoencephalography (MEG) or transcranial magnetic stimulation (TMS). All these methods provide different, but complementary, information about the functional areas of the brain. ...

  15. In vivo fluorescence kinetics and localisation of aluminium phthalocyanine disulphonate in an autologous tumour model

    Witjes, MJH; Speelman, OC; Nikkels, PGJ; Nooren, CAAM; Nauta, JM; vanderHolt, B; vanLeengoed, HLLM; Roodenburg, JLN

    1996-01-01

    Sulphonated phthalocyanines are studied as photosensitisers for photodynamic therapy of cancer. Their strong fluorescence and tumour-localising properties make them also potentially useful for detection of cancer by fluorescence. For this purpose, we have studied the fluorescence kinetics and locali

  16. Localisation of Sensor Nodes with Hybrid Measurements in Wireless Sensor Networks †

    Khan, Muhammad W.; Salman, Naveed; Kemp, Andrew H.; Mihaylova, Lyudmila

    2016-01-01

    Localisation in wireless networks faces challenges such as high levels of signal attenuation and unknown path-loss exponents, especially in urban environments. In response to these challenges, this paper proposes solutions to localisation problems in noisy environments. A new observation model for localisation of static nodes is developed based on hybrid measurements, namely angle of arrival and received signal strength data. An approach for localisation of sensor nodes is proposed as a weighted linear least squares algorithm. The unknown path-loss exponent associated with the received signal strength is estimated jointly with the coordinates of the sensor nodes via the generalised pattern search method. The algorithm’s performance validation is conducted both theoretically and by simulation. A theoretical mean square error expression is derived, followed by the derivation of the linear Cramer-Rao bound which serves as a benchmark for the proposed location estimators. Accurate results are demonstrated with 25%–30% improvement in estimation accuracy with a weighted linear least squares algorithm as compared to linear least squares solution. PMID:27455268

  17. Characterisation of a novel proteolytic enzyme localised to goblet cells in rat and man

    Poulsen, Steen Seier

    1984-01-01

    A proteolytic enzyme, ingobsin , purified from rat duodenal extracts is shown to be localised to intestinal goblet cells of both man and rat. Enzyme positive cells decrease in number from duodenum to colon. The enzyme is a 33 000 Mr protein with an isoelectric point of 5.1. The pH optimum for...

  18. Local characterisation of fluid flow in sandstone with localised deformation features through fast neutron imaging

    Rowe S.

    2010-06-01

    Full Text Available Understanding fluid flow through rocks is of key interest in hydrocarbon production and CO2 sequestration, amongst other applications. Such fluid injection or extraction from subsurface reservoirs can be significantly modified (increased or decreased by deformation and in particular by localised deformation features (fractures, shear bands and compaction bands. How such deformation alters fluid flow is however not well characterised experimentally. Measurement of fluid-flow distributions throughout a specimen requires techniques that can, first, see inside a test specimen and, second, see the fluid distinctly from the solid part. Therefore, neutron absorption imaging is well adapted to fluid flow monitoring in rocks as water is largely opaque to neutrons (i.e., it is highly absorbing and rocks are generally less absorbing. In this paper we present initial results of neutron radiography monitoring of fluid-flow through samples of a sandstone containing localised deformation features (shear-bands. A comparison of flow through an intact specimen and flow through samples containing localised deformation features is presented that provides insight into the effect of localised deformation on the flow properties.

  19. Food irradiation

    Food irradiation is a promising technology in which food products are exposed to a controlled amount of radiant energy to eliminate disease-causing bacteria. The process can also control parasites and insects, reduce spoilage and inhibit ripening and sprouting. Food irradiation is endorsed by the most important health organisations (WHO, CDC, USDA, FDA, EFSA, etc.) and allowed in nearly 40 Countries. It is to remember that irradiation is not a substitute either for comprehensive food safety programs or for good food-handling practices. Irradiated foods must be labelled with either the statement treated with radiation or treated by irradiation and the international symbol for irradiation, the radura. Some consumer associations suppose negative aspects of irradiation, such as increase of the number of free radicals in food and decrease of antioxidant vitamins that neutralize them

  20. Microautoradiographic localisation of [3H]sucrose and [3H]mannitol in Robinia pseudoacacia pulvinar tissues during phytochrome-mediated nyctinastic closure.

    Moysset, L; Llambrich, E; López-Iglesias, C; Simón, E

    2006-11-01

    We have analysed the incorporation of [(3)H]sucrose and [(3)H]mannitol in pulvinar motor cells of Robinia pseudoacacia L. during phytochrome-mediated nyctinastic closure. Pairs of leaflets, excised 2 h after the beginning of the photoperiod, were fed with 50 mM [(3)H]sucrose or [(3)H]mannitol, irradiated with red (15 min) or far-red (5 min) light and placed in the dark for 2-3 h. Label uptake was measured in whole pulvini by liquid scintillation counting. The distribution of labelling in pulvinar sections was assessed by both light and electron microautoradiography. [(3)H]Sucrose uptake was twice that of [(3)H]mannitol incorporation in both red- and far-red-irradiated pulvini. In the autoradiographs, [(3)H]sucrose and [(3)H]mannitol labelling was localised in the area from the vascular bundle to the epidermis, mainly in vacuoles, cytoplasm, and cell walls. Extensor and flexor protoplasts displayed a different distribution of [(3)H]sucrose after red and far-red irradiation. Far-red light drastically reduced the [(3)H]sucrose incorporation in extensor protoplasts and caused a slight increase in internal flexor protoplasts. After red light treatment, no differences in [(3)H]sucrose labelling were found between extensor and flexor protoplasts. Our results indicate a phytochrome control of sucrose distribution in cortical motor cells and seem to rule out the possibility of sucrose acting as an osmoticum. PMID:17102931

  1. Mathematical model for predicting the probability of acute mortality in a human population exposed to accidentally released airborne radionuclides. Final report for Phase I

    Filipy, R.E.; Borst, F.J.; Cross, F.T.; Park, J.F.; Moss, O.R.; Roswell, R.L.; Stevens, D.L.

    1980-05-01

    A mathematical model was constructed for the purpose of predicting the fraction of human population which would die within 1 year of an accidental exposure to airborne radionuclides. The model is based on data from laboratory experiments with rats, dogs and baboons, and from human epidemiological data. Doses from external, whole-body irradiation and from inhaled, alpha- and beta-emitting radionuclides are calculated for several organs. The probabilities of death from radiation pneumonitis and from bone marrow irradiation are predicted from doses accumulated within 30 days of exposure to the radioactive aerosol. The model is compared with existing similar models under hypothetical exposure conditions. Suggestions for further experiments with inhaled radionuclides are included. 25 refs., 16 figs., 13 tabs.

  2. Using the 'PARIS' software for the preparation of post-accidental situations

    PARIS (Post-accidental Radiological Imitation System) is a software developed by the Russian Radiological Protection Institute (IBRAE) at the request of IPSN (French Nuclear Protection and Safety Institute). Its objective is the modelling of post-accidental situations. The PARIS code allows one, in fact, to generate post-accidental scenarios, by simulating the different data flows, notably measurement results, such as they could reach the experts in a real-life situation. The PARIS software is presented, covering its principles, architecture, functions, specifications and application examples. (R.P.)

  3. Pre-accidental situations highlighted by RECUPERARE method and data

    Matahri, N. [Institut de Radioprotection et de Surete Nucleaire (IRSN), 92 - Fontenay-aux-Roses (France)

    2006-07-01

    RECUPERARE method has been developed for operating feedback analysis and built on the French Human Reliability Analysis (HRA) principles. It is used to study the causes of human errors or technical failures occurred in French PWRs and the recovery process of events. Based on an event classification (6 categories) model according to the nature of the link between failure and recovery, the identified and recorded data are: the causes of the defects (technical, human, organizational) and the context in which they appear; the factors of the recovery performance (depending on technical and organizational aspects); a chronological analysis, designed to collect delays between failures and their detection/recovery for each event. About 3600 events reported in French PWRs (1997-2003) had been reviewed through this model. Initially, the weight of factors and the most important factors, which influenced the detection and recovery delay, are defined. For this purpose, the regression Partial Least Square (PLS) is used. Then, to link RECUPERARE results with pre-accidental data, conditional probabilities of events linked between them by a cause and effect relationship are calculated. For this, the Bayesian method with the Bayesian network is built with the PLS obtained results and applied. This constitutes a first approach to take into account in HRA the human and organizational factors highlighted by operating feedback. (author)

  4. Learning From Biomarkers in Victims Accidentally Exposed to Ionizing Radiation

    Yan Wang; Liqing Du; Chang Xu; Qin Wang; Zhiyi Song; Jianxiang Liu; Xu Su

    2016-01-01

    Biomarkers,such as chromosome aberration and micronuclei assays,prove to be reliable for facilitating clinical diagnosis in radiation accidents.In a radiation accident in India,chromosomal aberration,γ-H2AX,as well as other blood markers,were detected in accidentally exposed victims.This multi-parametric approach aided in confirming that individuals had been exposed by ionizing radiation.However,doses were impossible to estimate because of a 30-day delay in accident awareness.Exposure dose for victims was estimated using a dose-response curve previously established.Dose estimation,blood cell depletion kinetics,and no appearance of prodromal symptoms suggested that doses of exposure were low.Hematologic investigation,sampling time,and chromosome aberration scoring were all proposed according to data from the victims exposed to 60Co.Finally,knowledge regarding chromosome aberration analysis and the importance of international co-operation and assistance should be shared from this accident.

  5. Non-Accidental Flecainide Overdose - A Case Report

    Abdelilah Ghannam

    2014-12-01

    Full Text Available Flecainide acetate is an antiarrhythmic drug used in the treatment of supraventricular arrhythmias. Flecainide causes very rare but often serious intoxications. These intoxications happen either due to a non-accidental overdose or because of a narrow therapeutic index in a patient who suffers from cardiomyopathy or has electrolyte abnormalities. We report an original case of a patient who had taken a high dose of flecainide with the aim of suicide. The patient suffered a cardiogenic shock with complications of lactic metabolic acidosis. Fast diagnosis is essential to reduce the high morbidity and mortality of this intoxication. The treatment plan is symptomatic. It aims at eliminating the poison and compensating cardiac function by treating the shock and the electrolyte imbalances. This allowed us to swiftly regain normal electrical and mechanical cardiac function in our patient. 3 weeks after the psychiatric consultation no sequelae were found. This case highlights that thorough history is essential in order to determine the diagnosis of a drug intoxication since the range of used products is wide. On the other hand, in case of any intoxication, while we apply a specific treatment, a well-managed, systematic, symptomatic treatment is essential to reduce morbidity and mortality.

  6. Environmental behaviour of accidentally released radionuclides in urban environments

    After a nuclear accident several radionuclides may be released and may contribute to the exposure of members of the public. After the passage of the radioactive cloud, doses to members of the public are mainly due to deposited radionuclides on the ground and other environmental surfaces. For the long-term it is already known that exposure is dominated by Cs-137, although Sr isotopes may also have a significant contribution is some specific environments, related to internal exposure pathways. However, in the first year, Ru and I isotopes may significantly contribute to the exposure of members of the public, from both external and internal exposure pathways. The objective of this work was to gather data on the environmental behaviour of Sr, I and Ru isotopes on urban environments and its contributions to the population exposure, aiming the support for decision making processes on countermeasures to protect people after an accidental release. Results on relative relevance of radionuclides and pathways for the exposure for members of the public, as a function of age and time after the release, are discussed. (author)

  7. Kinematics and kinetics of an accidental lateral ankle sprain.

    Kristianslund, Eirik; Bahr, Roald; Krosshaug, Tron

    2011-09-23

    Ankle sprains are common during sporting activities and can have serious consequences. Understanding of injury mechanisms is essential to prevent injuries, but only two previous studies have provided detailed descriptions of the kinematics of lateral ankle sprains and measures of kinetics are missing. In the present study a female handball player accidentally sprained her ankle during sidestep cutting in a motion analysis laboratory. Kinematics and kinetics were calculated from 240 Hz recordings with a full-body marker setup. The injury trial was compared with two previous (non-injury) trials. The injury trial showed a sudden increase in inversion and internal rotation that peaked between 130 and 180 ms after initial contact. We observed an attempted unloading of the foot from 80 ms after initial contact. As the inversion and internal rotation progressed, the loads were likely to exceed injury threshold between 130 and 180 ms. There was a considerable amount of dorsiflexion in the injury trial compared to neutral flexion in the control trials, similar to the previously published kinematical descriptions of lateral ankle sprains. The present study also adds valuable kinetic information that improves understanding of the injury mechanism. PMID:21824618

  8. Prolonged Toxic Encephalopathy following Accidental 4-Aminopyridine Overdose

    Maria Ballesta Méndez

    2014-01-01

    Full Text Available Background. 4-Aminopyridine (4-AP is a drug that is used to improve motor fatigue in patients suffering from multiple sclerosis (MS. Medication error can occur, as commercial preparation may not be available in some countries. Case Presentation. A 58-year-old woman with progressive MS presented with status epilepticus. She was receiving 4-AP for more than 3 years. The symptoms started soon after the ingestion of a single pill that was supposed to contain 10 mg 4-AP, but further investigations revealed that each pill had been inadvertently prepared with an 100 mg 4-AP concentration. The patient was admitted to the intensive care unit (ICU for appropriate management (orotracheal intubation, sedation, and antiepileptic drugs. The first electroencephalogram (EEG showed abundant irregular spike-waves on the left central regions. Neurological condition gradually improved from day 7, while the EEG did not reveal any more electrical seizures but was still consistent with toxic encephalopathy. The patient stayed in the ICU until day 13. At discharge from the rehabilitation ward (2.5 months later, the patient had not yet recovered her previous cognitive and functional condition. Conclusion. A single 100 mg 4-AP accidental overdose may cause serious immediate complications, with a slow and incomplete neurological recovery.

  9. Accidental over-exposure from dental X-ray equipment

    A description is given of an unusual dental X-ray procedure which resulted in accidental over-exposure both to the dentist and to several of his patients when a short-circuit was present in newly-installed equipment. The short-circuit by-passed the exposure control and energized the tube for certain orientations of the X-ray tube. The dentist left the patients, who wore protective aprons, to initiate the exposure themselves, using the control button. Although the warning lights were on, the dentist was not present in the room during the exposure, and the over-exposures were only detected when the developed X-ray films were found to be completely blackened. A reconstruction of the procedure enabled estimates to be made of the dose equivalents to the dentist's body and to the skin of the head, the eyes and the gonads of the patients. The dentist had overlooked several of basic principles recommended in the Code of Practice for the Protection of Persons against Ionizing Radiations from Medical and Dental Use (1972). It is pointed out that incidents involving failure of dental equipment (usually the timer mechanism) are not infrequent. (U.K.)

  10. Taking in account of contextual parameters in post accidental radioecology

    The consequences on agricultural or breeding products of a radioactive accidental release are strongly linked to the context in which radioactive deposits occur: for example conditions of deposition in relation with agricultural and feeding schedules. These contextual parameters lead to a variation of results given by models greater than transfer factors uncertainties. For example, cow milk contamination stretches on several decades during the months following deposit as a function of feeding practices. In the same way, if a wheat plant receives the deposit during grain development, harvested grains will have a contamination level 103 to 104 times higher that if deposition occurs before the growing stage. To create a decision support system like the ASTRAL software, the need to realize a modelling of these contextual parameters has been encountered. Moreover, to help experts for evaluations, default informations relative to agricultural and breeding practices for France are given through databases. However, in case of a real accident, it would be important to re-initialize these contextual parameters which change from year to year, in order to obtain more precise assessments. (authors)

  11. Accidental Cutaneous Burns Secondary to Salbutamol Metered Dose Inhaler

    Ashutosh Kale

    2010-01-01

    Full Text Available We report a case of accidental cutaneous burns caused by salbutamol metered dose inhaler. A 9-year-old boy underwent dental extraction at a children's hospital and was incidentally noted to have burn injuries on dorsum of both hands. On questioning, the boy revealed that a few days ago his 14-year-old brother, who is an asthmatic, playfully sprayed his salbutamol metered dose inhaler on the back of both his hands with the inhaler's mouth piece being in direct contact with the patient's skin. On examination, there was a rectangular area of erythema with superficial peeling on the dorsum of both hands, the dimensions of which exactly matched those of the inhaler's mouthpiece. It is possible that the injury could have been a chemical burn from the pharmaceutical/preservative/propellant aerosol or due to the physical effect of severe cooling of the skin or mechanical abrasive effect of the aerosol blasts or a combination of some or all the above mechanisms. This case highlights the importance of informing children and parents of the potentially hazardous consequences of misusing a metered dose inhaler.

  12. Funciones superiores en pacientes con accidente cerebro vascular.

    Felipe Rodríguez

    2009-07-01

    Full Text Available Los estudios realizados en Chile hasta la fecha no permiten detectar de manera significativa el deterioro neuropsicológico causado por el accidente cerebro vascular (ACV y el impacto que éste tiene en el paciente a nivel de su desenvolvimiento diario y familiar. Con base a esto el objetivo de esta investigación fue elaborar un perfil de deterioro neuropsicológico de las diversas funciones cerebrales superiores causado por un ACV, en un grupo de 50 pacientes de la Unidad de Medicina Física del Hospital San José al cuál se le administró un Protocolo de Evaluación Neuropsicológica, comparándose luego con un grupo control de 50 sujetos evaluados con el mismo protocolo. Se encuentra que sobre un 20% de la población con ACV evaluada presenta deterioro en al menos uno de los ítems evaluados, siendo las funciones ejecutivas, la memoria a largo plazo y la memoria a corto plazo las áreas mayoritariamente afectada en la población evaluada.

  13. Pre-accidental situations highlighted by RECUPERARE method and data

    RECUPERARE method has been developed for operating feedback analysis and built on the French Human Reliability Analysis (HRA) principles. It is used to study the causes of human errors or technical failures occurred in French PWRs and the recovery process of events. Based on an event classification (6 categories) model according to the nature of the link between failure and recovery, the identified and recorded data are: the causes of the defects (technical, human, organizational) and the context in which they appear; the factors of the recovery performance (depending on technical and organizational aspects); a chronological analysis, designed to collect delays between failures and their detection/recovery for each event. About 3600 events reported in French PWRs (1997-2003) had been reviewed through this model. Initially, the weight of factors and the most important factors, which influenced the detection and recovery delay, are defined. For this purpose, the regression Partial Least Square (PLS) is used. Then, to link RECUPERARE results with pre-accidental data, conditional probabilities of events linked between them by a cause and effect relationship are calculated. For this, the Bayesian method with the Bayesian network is built with the PLS obtained results and applied. This constitutes a first approach to take into account in HRA the human and organizational factors highlighted by operating feedback. (author)

  14. Calidad de vida de cuidadores de adultos con accidente cerebrovascular

    INNA ELIDA FLÓREZ TORRES

    2010-10-01

    Full Text Available Objetivo: describir la calidad de vida de los cuidadores familiares de adultos con secuelas de accidente cerebrovascular, en Cartagena, Colombia. Método: estudio descriptivo cuantitativo realizado durante el segundo semestre de 2008. Muestra no probabilística por conveniencia de 97 cuidadores. Se empleó el instrumento propuesto por Ferrell et ál. Para valorar cada uno de los bienestares que integran la calidad de vida se utilizaron medidas de tendencia central y coeficiente de variación. Resultados: el grupo de cuidadores presentó en el bienestar físico un promedio de 11,1 con relación al máximo puntaje, lo que indica el peor estado de salud; los bienestares psicológico y social tuvieron promedios de 48,8 y 21,9, respectivamente, con menor afectación. El mejor estado se halló en el bienestar espiritual, con promedio de 22,6. Conclusiones: la experiencia de ser cuidador modifica de manera importante la calidad de vida de las personas; los cuidadores, como fuente importante de cuidado informal, requieren apoyo de los sistemas de salud y, como parte de este, de los profesionales de enfermería.

  15. Deposition on holm oak leaf surfaces of accidentally released radionuclides

    Rauret, G.; Tent, J.; Rigol, A.; Llaurado, R.M. (Analytical Chemistry Department, University of Barcelona, Barcelona (Spain)); Alegre, L.H.; Utrillas, M.J. (Vegetal Biology Department, University of Barcelona, Barcelona (Spain))

    1994-10-14

    The retention of aerosols by canopies of holm oak trees in a typical Mediterranean forest is studied. Firstly, dry deposition is measured both under and outside the canopy during several months. No clear differences are observed either in the amount or in the chemical composition of the particles collected under and outside the canopy. Secondly, the leaf morphology and anatomy as well as the aerosol deposited onto the leaf surfaces are studied by scanning electron microscopy. Cuticle thickness is measured and differences are observed between young and old leaves. The distribution of aerosol particles over leaf surface is also established. Finally, the possible incorporation into leaves of a radioactive aerosol released in an accidental situation is studied, by means of a sequential extraction procedure using water and an organic solvent. From the results it can be deduced that neither the abiotic layer nor the cuticle play any important role in the retention of caesium. The studied radionuclides are mainly found in particulate form, soluble in water, or incorporated into leaves.

  16. The nature of carrier localisation in polar and nonpolar InGaN/GaN quantum wells

    Dawson, P.; Schulz, S.; Oliver, R. A.; Kappers, M. J.; Humphreys, C. J.

    2016-05-01

    In this paper, we compare and contrast the experimental data and the theoretical predictions of the low temperature optical properties of polar and nonpolar InGaN/GaN quantum well structures. In both types of structure, the optical properties at low temperatures are governed by the effects of carrier localisation. In polar structures, the effect of the in-built electric field leads to electrons being mainly localised at well width fluctuations, whereas holes are localised at regions within the quantum wells, where the random In distribution leads to local minima in potential energy. This leads to a system of independently localised electrons and holes. In nonpolar quantum wells, the nature of the hole localisation is essentially the same as the polar case but the electrons are now coulombically bound to the holes forming localised excitons. These localisation mechanisms are compatible with the large photoluminescence linewidths of the polar and nonpolar quantum wells as well as the different time scales and form of the radiative recombination decay curves.

  17. Subcellular localisation of Medicago truncatula 9/13-hydroperoxide lyase reveals a new localisation pattern and activation mechanism for CYP74C enzymes

    Hughes Richard K

    2007-11-01

    Full Text Available Abstract Background Hydroperoxide lyase (HPL is a key enzyme in plant oxylipin metabolism that catalyses the cleavage of polyunsaturated fatty acid hydroperoxides produced by the action of lipoxygenase (LOX to volatile aldehydes and oxo acids. The synthesis of these volatile aldehydes is rapidly induced in plant tissues upon mechanical wounding and insect or pathogen attack. Together with their direct defence role towards different pathogens, these compounds are believed to play an important role in signalling within and between plants, and in the molecular cross-talk between plants and other organisms surrounding them. We have recently described the targeting of a seed 9-HPL to microsomes and putative lipid bodies and were interested to compare the localisation patterns of both a 13-HPL and a 9/13-HPL from Medicago truncatula, which were known to be expressed in leaves and roots, respectively. Results To study the subcellular localisation of plant 9/13-HPLs, a set of YFP-tagged chimeric constructs were prepared using two M. truncatula HPL cDNAs and the localisation of the corresponding chimeras were verified by confocal microscopy in tobacco protoplasts and leaves. Results reported here indicated a distribution of M.truncatula 9/13-HPL (HPLF between cytosol and lipid droplets (LD whereas, as expected, M.truncatula 13-HPL (HPLE was targeted to plastids. Notably, such endocellular localisation has not yet been reported previously for any 9/13-HPL. To verify a possible physiological significance of such association, purified recombinant HPLF was used in activation experiments with purified seed lipid bodies. Our results showed that lipid bodies can fully activate HPLF. Conclusion We provide evidence for the first CYP74C enzyme, to be targeted to cytosol and LD. We also showed by sedimentation and kinetic analyses that the association with LD or lipid bodies can result in the protein conformational changes required for full activation of the enzyme

  18. Non-accidental pediatric trauma: radiographic findings in the abused child

    Deltoff, Marshall

    1994-01-01

    The common radiographic manifestations of abused children are discussed along with the mandated obligation of the doctor to recognize and report any reasonable suspicion of non-accidental trauma in his/her pediatric patients.

  19. The radioelectronic equipment as object the theories hiperbolic-accidental of the phenomena

    J. F. Zinkovskiy

    2010-01-01

    Full Text Available The problems of definition of parameters of functional assignment radioelectronic apparatus are considered at designing on the basis of the theory hyperbolic-accidental of the phenomena

  20. Fate of Accidental Symmetries of the Relativistic Hydrogen Atom in a Spherical Cavity

    Al-Hashimi, M H; Wiese, U -J

    2015-01-01

    The non-relativistic hydrogen atom enjoys an accidental $SO(4)$ symmetry, that enlarges the rotational $SO(3)$ symmetry, by extending the angular momentum algebra with the Runge-Lenz vector. In the relativistic hydrogen atom the accidental symmetry is partially lifted. Due to the Johnson-Lippmann operator, which commutes with the Dirac Hamiltonian, some degeneracy remains. When the non-relativistic hydrogen atom is put in a spherical cavity of radius $R$ with perfectly reflecting Robin boundary conditions, characterized by a self-adjoint extension parameter $\\gamma$, in general the accidental $SO(4)$ symmetry is lifted. However, for $R = (l+1)(l+2) a$ (where $a$ is the Bohr radius and $l$ is the orbital angular momentum) some degeneracy remains when $\\gamma = \\infty$ or $\\gamma = \\frac{2}{R}$. In the relativistic case, we consider the most general spherically and parity invariant boundary condition, which is characterized by a self-adjoint extension parameter. In this case, the remnant accidental symmetry is ...

  1. Accidental hanging deaths in children in Konya, Turkey between 1998 and 2007.

    Dogan, Kamil H; Demirci, Serafettin; Erkol, Zerrin; Gulmen, Mete K

    2010-05-01

    In general, hanging cases are the result of suicide, and accidental and homicidal hanging cases are rarely seen. This study retrospectively investigated 4571 death examinations and autopsies that were performed at The Konya Branch of the Forensic Medicine Council (Turkey) between 1998 and 2007; hanging was involved in 201 (6.5%) of the cases. There were a total of 13 accidental hanging cases, where 12 of these involved children. In seven of the cases, the accidental hanging involved a scarf that wraps around swing-like cradles and is intended to prevent infants from falling down. It was concluded that accidental hanging deaths can be reduced by replacing swing-like cradles with cribs that are designed for children, removing ropes in and around the house, and preventing children from reaching and/or playing with rope-like objects. PMID:20202070

  2. Regulation for the radiological safety in the design and operation of industrial Gamma irradiators in Egypt

    Large gamma irradiators present a high potential irradiation hazard since the amount of radioactivity is of the order of P Bq and a very high dose rate are produced during irradiation. Nevertheless, individuals may accidentally receive a lethal dose within minutes or seconds, due to failure of radiation control and safety systems. The competent authority (NCNSRC) is concerned with the impact of all radiation activities on workers as well as public health and safety. Radiation control of such large irradiation facilities can be achieved by means of strict regulatory procedures during construction, licensing, operation, inspection, maintenance and decommissioning

  3. Simple battery armor to protect against gastrointestinal injury from accidental ingestion

    Laulicht, Bryan; Traverso, Giovanni; Deshpande, Vikram; Langer, Robert; Karp, Jeffrey M.

    2014-01-01

    Accidental battery ingestion in children is a recognized source of significant morbidity and mortality. To mitigate the risks of accidental battery ingestion, legislation has been introduced to regulate the locking of battery compartments. Regulation of battery housings has translated into modest reductions in the number of battery ingestion cases reported. We report here the fabrication of waterproof, pressure-sensitive battery coatings that are nonconductive in the low-pressure gastrointest...

  4. Fate of accidental symmetries of the relativistic hydrogen atom in a spherical cavity

    Al-Hashimi, M. H.; Shalaby, A. M.; Wiese, U. -J.

    2015-01-01

    The non-relativistic hydrogen atom enjoys an accidental $SO(4)$ symmetry, that enlarges the rotational $SO(3)$ symmetry, by extending the angular momentum algebra with the Runge-Lenz vector. In the relativistic hydrogen atom the accidental symmetry is partially lifted. Due to the Johnson-Lippmann operator, which commutes with the Dirac Hamiltonian, some degeneracy remains. When the non-relativistic hydrogen atom is put in a spherical cavity of radius $R$ with perfectly reflecting Robin bounda...

  5. Menace of childhood non-accidental traumatic brain injuries: A single unit report

    Musa Ibrahim; Adamu Ladan Mu′azu; Nura Idris; Musa Uba Rabiu; Binta Wudil Jibir; Kabir Ibrahim Getso; Mohammad Aminu Mohammad; Femi Luqman Owolabi

    2015-01-01

    Background: Childhood traumatic brain injury (TBI) has high rate of mortality and morbidity worldwide. There are dearths of reports from developing countries with large paediatric population on trauma; neurosurgery trauma of nonaccidental origin is not an exemption. This study analysed menace of non-accidental TBI in the paediatric population from our center. Materials and Methods: This is a single unit, retrospective study of the epidemiology of non-accidental TBI in children starting from S...

  6. Concept of radiological, medical and social protection of the population of Russia affected by accidental exposure

    Main principles of population radiation protection from various accidental exposure, including the Chernobyl accident, have been implemented in officially approved Concept ''On radiological, medical, social protection and rehabilitation of the Russian Federation population affected by accidental radiation exposure''. The concept includes basic principles of radiation protection, designation of regional radionuclide contaminated territories, records and registers of exposed persons, health protection and rehabilitation, socio-economic and legal aspects

  7. Experiments in support to the understanding of fuel cladding behavior in normal, accidental and storage conditions at the CEA LECI hotlab facility

    This paper presents the experimental capabilities dedicated to the characterization of fuel cladding material behaviour in normal, accidental and storage conditions of the CEA Saclay LECI hotlab facility. The main objective of the LECI facility, that operates 45 hotcells, is to provide metallurgical, mechanical and physico-chemical data on irradiated materials (from fuel assembly, core structure, and vessel) in support to the operation of light water reactors as well as the development of future nuclear systems. Specifically, a comprehensive review of the available equipment which can be used to characterize a broad range of properties of irradiated cladding materials for Gen2 and 3 nuclear applications is presented. These data are then used to identify normal, accidental or storage conditions behaviour laws and models able to predict the in-service lifetime of the materials. The mechanical properties of irradiated zirconium alloy cladding are characterized through a complete set of mechanical testing such as tensile, creep and burst tests. Specific experiments have been developed in order to obtain the mechanical properties in axial, circumferential and biaxial conditions, or to simulate LOCA or RIA transients. Fine metrology tools give access to dimensional variations at the μm scale after various irradiation experiments performed in MTR, that address creep and growth under irradiation. State-of the-art equipment, including optical microscopy with image analysis for hydride content and distribution (HydruroTM), FEG-Scanning Electron Microscopy fitted with EDS, WDS and EBSD, Transmission Electron Microscopy, Electron Probe MicroAnalysis, hydrogen global measurement, and Nuclear Reaction Analysis, allow the characterization of key parameters to address the cladding behavior: precipitate phase evolution and nucleation and growth of irradiation defects, hydrogen precipitation and reorientation, structure and microstructure of oxide layers formed, fracture mode after

  8. Irradiated planets

    We present models for the spectra emitted by irradiated planets and discuss the numerical methods used in the modeling. In addition, we show results of simple 3D calculations that are designed as a first step toward detailed multi-dimensional models of irradiated planets

  9. Food irradiation

    The paper discusses the need for effective and efficient technologies in improving the food handling system. It defines the basic premises for the development of food handling. The application of food irradiation technology is briefly discussed. The paper points out key considerations for the adoption of food irradiation technology in the ASEAN region (author)

  10. Food irradiation

    The author reviews in outline the present status of industrial gamma irradiation plants for food and medical sterilization and in particular lists commercial irradiation plants currently operating in the U.K., considering briefly plant design, efficiency, costs and dose control. (UK)

  11. Optimal sizes and siting of nuclear fuel reprocessing plants; Tailles et localisations optimales des usines de retraitement des combustibles nucleaires

    Thiriet, L.; Deledicq, A. [Commissariat a l' Energie Atomique, Siege (France). Centre d' Etudes Nucleaires

    1967-07-01

    titre d'exemple nous avons traite le probleme des usines de traitement de l'uranium naturel irradie associees a des centrales nucleaires a uranium naturel-graphite CO{sub 2}. La localisation et la production annuelle des reacteurs, les sites possibles d'usines et les fonctions de cout (transport et retraitement) sont supposes connus. La methode consiste a traiter d'abord le probleme des usines de traitement comme un probleme de programmation dynamique, des tranches croissantes de programmes (production totale des reacteurs) etant explorees sequentiellement. Lorsque les quantites d'uranium naturel irradie a retraiter sont fixees, la minimisation du cout de transport est alors effectuee, elle aussi comme un probleme de programmation dynamique. On explore le voisinage de l'optimum du cout de traitement pour trouver le minimum de la somme d'un cout de traitement sous-optimal et du cout de transport optimal correspondant. Le probleme de retraitement etant representable sur un graphe sequentiel, l'algorithme utilise pour calculer les sous-optima est 'l'algorithme a reflexion' que nous avons elabore. La methode s'interprete comme un mecanisme general de determination de l'optimum lorsque, a un probleme dynamique sequentiel (par exemple un programme d'equipement), se superpose un probleme complementaire (par exemple de transport). Elle permet en outre d'evaluer les pertes resultant du choix, pour des raisons autres qu'economiques, d'une politique non optimale. (auteur)

  12. An investigation into a suitable scintillator for localising neutron capture within a detector

    Using Monte-Carlo modelling, an investigation into a suitable loaded scintillator for localising neutron capture in a novel neutron survey meter has been undertaken. A comparison of estimated neutron capture location in a scintillator with Geant4 and MCNP simulations was undertaken and a good general agreement between the two models was observed. The interactions of γ emissions from neutron capture in the scintillator are investigated. The results show that the γ emission from neutron capture will not aid neutron capture localisation and will only inhibit it. It is observed that the lithium-loaded scintillator has the lowest neutron capture efficiency when compared with boron and gadolinium scintillators. However, it is the most promising of the detectors investigated in this research for use in a novel neutron survey meter design

  13. Critical Factors in Transnational Oil Companies Localisation Decisions - Clusters and Portfolio Optimisation

    Enhanced understanding of the factors determining trans national companies' localisation decisions is important for regulators and other stake holders concerned about maintaining current activity levels in a petroleum producing country. This article discusses localisation decisions in the context of theories of industrial clusters and real portfolio optimisation theory (materiality), which we argue are two fruitful lines of explanation for trans national companies' behaviour. The industrial cluster literature is concerned about the level of positive externalities associated with geographic clustering of related production activities. The concept of materiality, implying that investment projects in an oil province must be of a certain minimum size in order to be interesting for oil companies, is evaluated empirically and compared to predictions of mainstream economic theory. (author)

  14. THE PERITONEAL HYDATIC CYST – THE RARE PRIMARY LOCALISATION. CASE REPORT

    L. Dubei

    2010-05-01

    Full Text Available Primary peritoneal localisation of hydatic cyst is exceptional, because the first filter is the liver, the second is the lung and disemination is realised by haematogen way. Another particular situation is the breaking of univesicular hydatic cyst with migration of intact proligera and inseminations of Douglas peritoneum. In this last case is a not true primitive peritoneal localisation. We present a case of a 30 years old patient who comes to physician for hypogastric pains, polakiuria, disuria, rectal tenesma and “pencil-like” stools. Physical examination revealed an abdominal tumor in the hipogastrum and extrinsic compression of rectum superior at the rectal tact. An abdominal ultrasound scan showed a large cystic mass in the pelvis and bilateral ureterohidronefrosis. We realized an open intervention and found and resolved a hydatic cyst of Douglas recessus. The optimal approach – laparoscopic - was not possible because of technical conditions and the desire of patient.

  15. Critical Factors in Transnational Oil Companies Localisation Decisions - Clusters and Portfolio Optimisation

    Kind, Hans Jarle; Osmundsen, Petter; Tverteraas, Ragnar

    2001-10-01

    Enhanced understanding of the factors determining transnational companies' localisation decisions is important for regulators and other stakeholders concerned about maintaining current activity levels in a petroleum producing country. This article discusses localisation decisions in the context of theories of industrial clusters and real portfolio optimisation theory (materiality), which we argue are two fruitful lines of explanation for transnational companies' behaviour. The industrial cluster literature is concerned about the level of positive externalities associated with geographic clustering of related production activities. The concept of materiality, implying that investment projects in an oil province must be of a certain minimum size in order to be interesting for oil companies, is evaluated empirically and compared to predictions of mainstream economic theory. (author)

  16. Numerical modelling of bifurcation and localisation in cohesive-frictional materials

    de Borst, René

    1991-12-01

    Methods are reviewed for analysing highly localised failure and bifurcation modes in discretised mechanical systems as typically arise in numerical simulations of failure in soils, rocks, metals and concrete. By the example of a plane-strain biaxial test it is shown that strain softening and lack of normality in elasto-plastic constitutive equations and the ensuing loss of ellipticity of the governing field equations cause a pathological mesh dependence of numerical solutions for such problems, thus rendering the results effectively meaningless. The need for introduction of higher-order continuum models is emphasised to remedy this shortcoming of the conventional approach. For one such a continuum model, namely the unconstrained Cosserat continuum, it is demonstrated that meaningful and convergent solutions (in the sense that a finite width of the localisation zone is computed upon mesh refinement) can be obtained.

  17. CONGENITAL LOCALISED ABSENCE OF SKIN (BART’S SYNDROME RARE CASE REPORT

    Garima

    2014-12-01

    Full Text Available It is defined as congenital localised absence of skin associated with epidermolysis bullosa. It may be associated with any type of epidermolysis bullosa. Three cutaneous manifestation are characteristics of Bart syndrome: congenital localised absence of skin (CLAS, mucocutaneous blistering and nail abnormalities. It present as raw beefy areas of denuded skin on trauma prone site; extremity like hands and feet, also perioral area. Diagnosis is obvious clinically but requires ultrastructural microscopy. We describe here a case of newborn baby in our OPD who presented with raw beefy red areas of denuded skin on the hands, feet, neck area with few flaccid bulla near thigh. The patient was treated with antibiotic and steroid (fusidic acid + hydrocortisone cream and emollients. Thus, Clinical appearance was sufficiently distinct to suggest the diagnosis of Bart’s syndrome.

  18. Bringing order through disorder: Localisation of errors in topological quantum memories

    Wootton, James R

    2011-01-01

    The ability to reliably store quantum states is an essential element for any task in quantum information. Topological systems promise to protect quantum information by topological and energetic considerations. If undesired anyonic excitations are propagated at large distances, either through coherent or probabilistic processes, they can cause logical errors in the topologically encoded information. Here we show that Anderson localisation induced by disorder in the system can successfully protect topological quantum memories from the coherent propagation of anyons. For concreteness we employ the toric code model at zero temperature. It is known that in the absence of a magnetic field it can tolerate a finite initial density of anyonic errors. In the presence of a spurious magnetic field anyonic quantum walks are induced and the tolerable density becomes zero. We demonstrate that disorder in the couplings of the model can successfully localise anyons. This allows the topological quantum memory to tolerate a fin...

  19. Towards quantification of the interplay between strain weakening and strain localisation in granular material

    Ritter, Malte C.; Rosenau, Matthias; Leever, Karen; Oncken, Onno

    2014-05-01

    Strain weakening is the major agent of localisation of deformation into shear zones and faults at various scales in brittle media. Physical analogue models using granular material are especially apt to investigate both phenomena, because they are able to reproduce them without the need of any assumptions concerning the physics behind. Several attempts have been made to quantify either strain weakening (e. g. Lohrmann et al., 2003, using Ring-Shear tests) or strain localisation (e. g. Schrank et al., 2008, using a variation of the classical Riedel-experiment). While Ring-Shear tests yield excellent data on strain weakening through measuring shear stress during localisation, they do not allow monitoring the process of strain localisation in-situ because of experimental inaccessibility of the small scale kinematics. In Riedel-type strike-slip experiments, on the other hand, no direct measurements of shear stresses have been available so far. Furthermore, they contain a strong boundary condition in form of a pre-defined linear discontinuity at the base. This forces the formation of Riedel-Shears, i. e. a complex fault system, that makes it difficult to define strain localisation on single faults. We developed a new experimental set-up, in which the formation of a strike-slip shear zone in granular material is induced using an ndenter with stress and strain monitored at high accuracy and resolution. In a first set of experiments we used a horizontal sand layer indented by a vertical wall. The sand layer is laterally unconfined and rests on low-viscosity silicone oil in order to minimize basal shear strength. Compared to the Riedel experiments, this avoids the boundary condition of a pre-existing basal discontinuity allowing one single, hrough-going shear crack to form and propagate. The indenter moves at a constant rate and is equipped with a force sensor that measures the applied push, which integrates over shear stresses along the fault and the base of the sand pack

  20. Modelling impacts and recovery in benthic communities exposed to localised high CO2.

    Lessin, Gennadi; Artioli, Yuri; Queirós, Ana M; Widdicombe, Stephen; Blackford, Jerry C

    2016-08-15

    Regulations pertaining to carbon dioxide capture with offshore storage (CCS) require an understanding of the potential localised environmental impacts and demonstrably suitable monitoring practices. This study uses a marine ecosystem model to examine a comprehensive range of hypothetical CO2 leakage scenarios, quantifying both impact and recovery time within the benthic system. Whilst significant mortalities and long recovery times were projected for the larger and longer term scenarios, shorter-term or low level exposures lead to reduced projected impacts. This suggests that efficient monitoring and leak mitigation strategies, coupled with appropriate selection of storage sites can effectively limit concerns regarding localised environmental impacts from CCS. The feedbacks and interactions between physiological and ecological responses simulated reveal that benthic responses to CO2 leakage could be complex. This type of modelling investigation can aid the understanding of impact potential, the role of benthic community recovery and inform the design of baseline and monitoring surveys. PMID:27289279

  1. Photon counting imaging and centroiding with an electron-bombarded CCD using single molecule localisation software

    Hirvonen, Liisa M.; Barber, Matthew J.; Suhling, Klaus

    2016-06-01

    Photon event centroiding in photon counting imaging and single-molecule localisation in super-resolution fluorescence microscopy share many traits. Although photon event centroiding has traditionally been performed with simple single-iteration algorithms, we recently reported that iterative fitting algorithms originally developed for single-molecule localisation fluorescence microscopy work very well when applied to centroiding photon events imaged with an MCP-intensified CMOS camera. Here, we have applied these algorithms for centroiding of photon events from an electron-bombarded CCD (EBCCD). We find that centroiding algorithms based on iterative fitting of the photon events yield excellent results and allow fitting of overlapping photon events, a feature not reported before and an important aspect to facilitate an increased count rate and shorter acquisition times.

  2. Localisation of Information and Communication Technologies in Cameroonian Languages and Cultures:Experience and Issues

    Mathurin Soh

    2015-12-01

    Full Text Available In this paper, we tackle the problem of adapting Information and Communication Technologies (ICTs in local languages of Cameroon. The objectives are to reduce the digital and language divides, and to pave the way for the usage of such technologies to local populations who don’t understand this technological language. We first discuss and highlight several concerns about the localisation of ICTs. Afterwords, we address some challenges and issues to computerize cultural and linguistic features, and indigenous knowledge (IK for national languages and cultures in Cameroon. As case study, we describe our experience in localising an open source editor for the Yemba language, within the of Rural Electronic Schools in African Languages Project. Because Cameroonian languages are based on the same basic alphabet, this qualitative research is extensible to other languages.

  3. Irradiation damage

    There is considerable interest in irradiation effects in intermetallic compounds from both the applied and fundamental aspects. Initially, this interest was associated mainly with nuclear reactor programs but it now extends to the fields of ion-beam modification of metals, behaviour of amorphous materials, ion-beam processing of electronic materials, and ion-beam simulations of various kinds. The field of irradiation damage in intermetallic compounds is rapidly expanding, and no attempt will be made in this chapter to cover all of the various aspects. Instead, attention will be focused on some specific areas and, hopefully, through these, some insight will be given into the physical processes involved, the present state of our knowledge, and the challenge of obtaining more comprehensive understanding in the future. The specific areas that will be covered are: point defects in intermetallic compounds; irradiation-enhanced ordering and irradiation-induced disordering of ordered alloys; irradiation-induced amorphization

  4. Food irradiation

    Food irradiation can have a number of beneficial effects, including prevention of sprouting; control of insects, parasites, pathogenic and spoilage bacteria, moulds and yeasts; and sterilization, which enables commodities to be stored for long periods. It is most unlikely that all these potential applications will prove commercially acceptable; the extend to which such acceptance is eventually achieved will be determined by practical and economic considerations. A review of the available scientific literature indicates that food irradiation is a thoroughly tested food technology. Safety studies have so far shown no deleterious effects. Irradiation will help to ensure a safer and more plentiful food supply by extending shelf-life and by inactivating pests and pathogens. As long as requirement for good manufacturing practice are implemented, food irradiation is safe and effective. Possible risks of food irradiation are not basically different from those resulting from misuse of other processing methods, such as canning, freezing and pasteurization. (author)

  5. Irradiation damage

    Howe, L.M

    2000-07-01

    There is considerable interest in irradiation effects in intermetallic compounds from both the applied and fundamental aspects. Initially, this interest was associated mainly with nuclear reactor programs but it now extends to the fields of ion-beam modification of metals, behaviour of amorphous materials, ion-beam processing of electronic materials, and ion-beam simulations of various kinds. The field of irradiation damage in intermetallic compounds is rapidly expanding, and no attempt will be made in this chapter to cover all of the various aspects. Instead, attention will be focused on some specific areas and, hopefully, through these, some insight will be given into the physical processes involved, the present state of our knowledge, and the challenge of obtaining more comprehensive understanding in the future. The specific areas that will be covered are: point defects in intermetallic compounds; irradiation-enhanced ordering and irradiation-induced disordering of ordered alloys; irradiation-induced amorphization.

  6. Confocal and conventional immunofluorescence and ultrastructural localisation of intracellular strength-giving components of human amniochorion.

    Ockleford, C; Malak, T; A. Hubbard; Bracken, K; Burton, S A; Bright, N.; Blakey, G; Goodliffe, J; Garrod, D; d'Lacey, C

    1993-01-01

    Key cytoskeletal polypeptides of human fetal membranes have been localised at subcellular level using confocal and conventional indirect immunofluorescence microscopy. Correlation with electron microscope data has allowed us to examine how cellular compartments of this multilaminar tissue maintain their mechanical integrity until the time of membrane rupture at parturition. Evidence is presented for myofibroblastic characteristics of cells in both the fibroblast and reticular layers which may...

  7. Early maize root and phosphorus uptake responses to localised application of sewage sludge derived fertilisers

    Lemming, Camilla; Oberson, Astrid; Hund, Andreas; Stoumann Jensen, Lars; Magid, Jakob

    2015-01-01

    Background: Phosphorus recycling from waste and localised placement of fertilisers can be means to improve sustainable P management in agriculture. However, knowledge about root and plant P uptake responses to placement of complex waste- derived fertilisers is lacking. Methods: Sewage sludge (SS) and sewage sludge ash (ASH) were tested against triple superphosphate (TSP) in a rhizobox setup where shoot and root growth of maize was followed for 30 days. The three P sources were either mixed...

  8. Space–time and hybrid algorithms for the passive acoustic localisation of sperm whales and vessels

    Houégnigan, Ludwig; Zaugg, Serge Alain; Van der Schaar, Mike Connor Roger Malcolm; André, Michel

    2010-01-01

    In the frame of the European Sea-floor Observatory Network (ESONET) and in preparation of the Demonstration Mission Listening to the Deep-Ocean Environment (LIDO) algorithms for the automated real-time detection, classification and localisation of cetaceans have been developed. Such Passive Acoustic Monitoring techniques have the potential to play a key role in cetaceans’ conservation for they allow a non-invasive study of their behaviour, a better knowledge of their population ...

  9. An investigation into a suitable scintillator for localising neutron capture within a detector

    Balmer, Matthew; Gamage, Kelum; Taylor, Graeme

    2014-01-01

    Using Monte-Carlo modelling, an investigation into a suitable loaded scintillator for localising neutron capture in a novel neutron survey meter has been undertaken. A comparison of estimated neutron capture location in a scintillator with Geant4 and MCNP simulations was undertaken and a good general agreement between the two models was observed. The interactions of γ emissions from neutron capture in the scintillator are investigated. The results show that the γ emission from neutron capture...

  10. Immunohistochemical Localisation of PDE5 in Rat Lung during Pre- and Postnatal Development

    Angela Scipioni; Mauro Giorgi; Valeria Nuccetelli; Stefania Stefanini

    2009-01-01

    In mammalian lung, at the transition to extrauterine life, NO/cGMP signal transduction system is known to play crucial roles in the regulation of vascular resistance and is supposed to act in angiogenesis. PDE5, which is the most abundant cGMP metabolizing enzyme within the lung, is highly expressed in the perinatal period, but its localisation in the different pulmonary cells is still poorly known. In our research, PDE5 immunohistochemical distribution was investigated in foetal and neonatal...

  11. Localised lymphoma of bone: prognostic factors and treatment recommendations. The Princess Margaret Hospital Lymphoma Group.

    Rathmell, A. J.; Gospodarowicz, M K; Sutcliffe, S.B.; Clark, R.M.

    1992-01-01

    Twenty seven adult patients with newly diagnosed non-Hodgkin's lymphoma localised to either bone (Stage IE) or bone and regional lymph nodes (Stage IIE) were treated between 1967 and 1988. Median age was 53 years and the commonest histology (21 patients) was diffuse histiocytic lymphoma. Twenty-four patients were treated radically: 15 with radiation therapy (XRT) alone and nine with chemotherapy plus radiation therapy (CMT). The cause specific survival for these patients was 56% at 5 years an...

  12. Local characterisation of fluid flow in sandstone with localised deformation features through fast neutron imaging

    Rowe S.; Hughes D.; Hall S.A.

    2010-01-01

    Understanding fluid flow through rocks is of key interest in hydrocarbon production and CO2 sequestration, amongst other applications. Such fluid injection or extraction from subsurface reservoirs can be significantly modified (increased or decreased) by deformation and in particular by localised deformation features (fractures, shear bands and compaction bands). How such deformation alters fluid flow is however not well characterised experimentally. Measurement of fluid-flow distributi...

  13. Localised Skin Hyperpigmentation as a Presenting Symptom of Vitamin B12 Deficiency Complicating Chronic Atrophic Gastritis

    Kawther El-Shafie; Nafisa Samir; Ritu Lakhtakia; Robin Davidson; Ahmed Al-Waili; Muna Al-Mamary; Mohammed Al-Shafee

    2015-01-01

    Vitamin B12 deficiency is common in developing countries and should be suspected in patients with unexplained anaemia or neurological symptoms. Dermatological manifestations associated with this deficiency include skin hyper- or hypopigmentation, angular stomatitis and hair changes. We report a case of a 28-year-old man who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in November 2013 with localised hyperpigmentation of the palmar and dorsal aspects of both hands of two...

  14. In planta localisation patterns of MADS domain proteins during floral development in Arabidopsis thaliana

    Urbanus, S.L.; Folter, de, S.; Shchennikova, A.; Kaufmann, K.; Immink, G.H.; Angenent, G.C.

    2009-01-01

    Background: MADS domain transcription factors play important roles in various developmental processes in flowering plants. Members of this family play a prominent role in the transition to flowering and the specification of floral organ identity. Several studies reported mRNA expression patterns of the genes encoding these MADS domain proteins, however, these studies do not provide the necessary information on the temporal and spatial localisation of the proteins. We have made GREEN FLUORESCE...

  15. Localisation binaurale active de sources sonores en robotique humanoïde

    Portello, Alban

    2013-01-01

    This thesis deals with the definition of algorithms for the localisation of still or moving sound sources from a mobile binaural sensor in robotics. The aim is to develop active strategies, combining left-right perceived signals with the sensor motor commands so as to overcome usual limitations in the case of a static world : resolve ambiguities (e.g. front-back), recover observability of variables, etc. The study focuses on two-step strategies : (1) extraction of spatial information and sour...

  16. Technological change and industry competitiveness through the evolution of localised comparative advantages - The case of Italy

    Palma, Daniela; Zini, Alessandro

    2005-01-01

    The influence of technological change on industry performances is nowadays being increasingly investigated under the broad category of "national systemic competitiveness". Moreover theoretical works have shown that the relationship between technology and economic performance not only takes different forms in different socio-economic contexts, but is also powerfully influenced by the way that innovation processes evolve over time along strongly localised patterns. The present study is focused ...

  17. Localised low velocity impact performance of short glass fibre reinforced polyamide 66 oil pans

    Mouti, Zakaria

    2012-01-01

    This thesis focuses on the mechanical properties of short glass fibre reinforced polyamide 66 material used in automotive composite structures, and its impact resistance under localised low velocity impact. The main application of this research concerns the impact performance of an oil pan component susceptible to stone impact damage. The thesis reviews the current state-of-the-art of thermoplastic polyamide materials with an overview of the glass fibre reinforced polyamide ...

  18. Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer

    Mizukami, Y.; Kono, K; Kawaguchi, Y; Akaike, H.; Kamimura, K.; Sugai, H.; Fujii, H.

    2007-01-01

    It has been reported that the population of regulatory T cells (T regs) is increased in tumour-infiltrating lymphocytes in cancer-bearing hosts. Recently, forkhead/winged helix transcription factor p3, Foxp3, is thought to be the most reliable marker of T regs. In the present study, we investigated the prevalence and localisation pattern of Foxp3+ cells in gastric cancer (n=80) by immunohistochemistry, in relation to the clinical outcome of gastric cancer patients. Immunohistochemical stainin...

  19. Ureteric angioplasty balloon placement to increase localised dosage of BCG for renal pelvis TCC.

    Forde, J C

    2012-03-01

    Endoscopic percutaneous resection of a renal pelvis transitional cell carcinoma (TCC) is a viable treatment option in those who would be rendered dialysis dependent following a nephroureterectomy. We report endoscopic percutaneous resection of an upper tract TCC recurrence in a single functioning kidney followed by antegrade renal pelvis BCG instillation with novel placement of inflated angioplasty balloon in the ureter to help localise its effect.

  20. Robust localisation of automated guided vehicles for computer-integrated manufacturing environments

    Dixon, R. C.; Bright, G.; Harley, R.

    2013-01-01

    As industry moves toward an era of complete automation and mass customisation, automated guided vehicles (AGVs) are used as material handling systems. However, the current techniques that provide navigation, control, and manoeuvrability of automated guided vehicles threaten to create bottlenecks and inefficiencies in manufacturing environments that strive towards the optimisation of part production. This paper proposes a decentralised localisation technique for an automated guided vehicle ...

  1. Cellular localisation of type XIII collagen, and its induced expression in human neoplasias and corneal diseases

    Väisänen, T. (Teemu)

    2005-01-01

    Abstract Type XIII collagen belongs to the group of transmembrane collagens. In this thesis the plasma membrane localisation and function of type XIII collagen have been studied using cell biological methods. Type XIII collagen was found to reside in focal adhesions. It appeared in these structures at a very early stage of their assembly and disappeared from them concurrently with focal adhesion proteins talin and vinculin. Insect cells expressing type XIII collagen showed an enhanced ...

  2. Auditory localisation of conventional and electric cars : laboratory results and implications for cycling safety

    Stelling-Konczak, A. & Hagenzieker, M.P.

    2016-01-01

    When driven at low speeds, cars operating in electric mode have been found to be quieter than conventional cars. As a result, the auditory cues which pedestrians and cyclists use to assess the presence, proximity and location oncoming traffic may be reduced, posing a safety hazard. This laboratory study examined auditory localisation of conventional and electric cars including vehicle motion paths relevant for cycling activity. Participants (N = 65) in three age groups (16–18, 30–40 and 65–70...

  3. Morphoea (localised scleroderma) in a patient with mixed connective tissue disease.

    Golding, D. N.

    1986-01-01

    An 18 year old girl concurrently developed skin lesions of morphoea (localised scleroderma) and pain and swelling of the hands and fingers. There were no dermatological or systemic signs of systemic sclerosis. The immunological features (high titred speckled antinuclear antibody, negative DNA binding, high titred positive anti-RNP and negative anti-Sm antibodies, speckled nuclear Ig fluorescence in the epidermis of the skin lesions) were consistent with mixed connective tissue disease, and it...

  4. Localisation of primary food production in Finland: production potential and environmental impacts of food consumption patterns

    Risku-Norja, Helmi; Hietala, Reija; Virtanen, Hanna; Ketomäki, Hanna; Helenius, Juha

    2008-01-01

    The potential for and environmental consequences of localising primary production of food were investigated by considering different food consumption patterns, based on conventional and organic production. Environmental impact was assessed according to agricultural land use and numbers of production animals, both of which depend on food consumption. The results were quantified in terms of nutrient balances, greenhouse gas and acid emissions and the diversity of crop cultivation, which indicat...

  5. Application of multiple-wireless to a visual localisation system for emergency services

    Efthymiou, C; Gormus, S; Fan, Zhong; Calway, AD; Mayol-Cuevas, WW; Doufexi, A

    2010-01-01

    In this paper we discuss the application of multiplewireless technology to a practical context-enhanced service system called ViewNet. ViewNet develops technologies to support enhanced coordination and cooperation between operation teams in the emergency services and the police. Distributed localisation of users and mapping of environments implemented over a secure wireless network enables teams of operatives to search and map an incident area rapidly and in full coordination with each other ...

  6. A Unified Scalable Model of User Localisation with Uncertainty Awareness for Large-scale Pervasive Environments

    Aksenov, Petr; Luyten, Kris; Coninx, Karin

    2011-01-01

    Localisation has become a standard feature in many mobile applications. Numerous techniques for both indoor and outdoor location tracking are available today, providing a diversity of ways positioning information can be delivered to a mobile application (e.g., a location-based service). Such factors as the variation of precision over time and covered areas or the difference in quality and reliability make the adoption of several techniques for one application cumbersome. ...

  7. Human perception of indoor environment generated by chilled ceiling combined with mixing ventilation or localised chilled beam under cooling mode

    Bolashikov, Zhecho Dimitrov; Nygaard, Linette; Uth, Simon C.;

    2014-01-01

    Experiments with 24 subjects were performed to study and compare the human perception of the indoor environment under summer conditions generated by a chilled ceiling combined with overhead mixing ventilation and localised chilled beam. The experiments were performed in an experimental chamber (4...... simulate direct solar load on the floor (270 W). The total heat load in the room was 56 W/m2. The air temperature around the workstation by the window was kept either 26 or 28 oC. The supplied air by the overhead mixing ventilation and the primary supply air of the localised chilled beam was kept at 13 L....../s and 16 0C. The localised chilled beam was installed over the workstation placed by the simulated window. During the experiment the subjects were delegated control over the primary flow rate supplied by the localised chilled beam. The whole exposure lasted 2 hours with 30 min of acclimatisation before...

  8. Genetic optimisation of a plane array geometry for beamforming. Application to source localisation in a high speed train

    Le Courtois, Florent; Thomas, Jean-Hugh; Poisson, Franck; Pascal, Jean-Claude

    2016-06-01

    Thanks to its easy implementation and robust performance, beamforming is applied for source localisation in several fields. Its effectiveness depends greatly on the array sensor configuration. This paper introduces a criterion to improve the array beampattern and increase the accuracy of sound source localisation. The beamwidth and the maximum sidelobe level are used to quantify the spatial variation of the beampattern through a new criterion. This criterion is shown to be useful, especially for the localisation of moving sources. A genetic algorithm is proposed for the optimisation of microphone placement. Statistical analysis of the optimised arrays provides original results on the algorithm performance and on the optimal microphone placement. An optimised array is tested to localise the sound sources of a high speed train. The results show an accurate separation.

  9. Weakly nonlinear analysis and localised structures in nonlinear cavities with metamaterials

    Slimani, N.; Makhoute, A.; Tlidi, M.

    2016-04-01

    We consider an optical ring cavity filled with a metamaterial and with a Kerr medium. The cavity is driven by a coherent radiation beam. The modelling of this device leads to the well known Lugiato-Lefever equation with high order diffraction term. We assume that both left-handed and right-handed materials possess a Kerr focusing type of nonlinearity. We show that close to the zero-diffraction regime, high-order diffraction effect allows us to stabilise dark localised structures in this device. These structures consist of dips or holes in the transverse profile of the intracavity field and do not exist without high-order diffraction effects. We show that high order diffraction effects alter in depth the space-time dynamics of this device. A weakly nonlinear analysis in the vicinity of the first threshold associated with the Turing instability is performed. This analysis allows us to determine the parameter regime where the transition from super- to sub-critical bifurcation occurs. When the modulational instability appears subcritically, we show that bright localised structures of light may be generated in two-dimensional setting. Close to the second threshold associated with the Turing instability, dark localised structures are generated.

  10. On The Role of MHD Waves in Heating Localised Magnetic Structures

    Erdélyi, R.; Nelson, C. J.

    2016-04-01

    Satellite and ground-based observations from e.g. SOHO, TRACE, STEREO, Hinode, SDO and IRIS to DST/ROSA, IBIS, CoMP, STT/CRISP have provided a wealth of evidence of waves and oscillations present in a wide range of spatial scales of the magnetised solar atmosphere. Our understanding about localised solar structures has been considerably changed in light of these high spatial and time resolution observations. However, MHD waves not only enable us to perform sub-resolution magneto-seismology of magnetic waveguides but are also potential candidates to carry and damp the necessary non-thermal energy in these localised waveguides. First, we will briefly outline the basic recent developments in MHD wave theory focussing on linear waves. Next, we discuss the role of the most frequently studied wave classes, including the Alfven, and magneto-acoustic kink and sausage waves. The current theoretical (and often difficult) interpretations of the detected solar atmospheric wave and oscillatory phenomena within the framework of MHD will be shown. Last, the latest reported observational findings of potential MHD wave flux, in terms of localised plasma heating, in the solar atmosphere is discussed, bringing us closer to solve the coronal heating problem.

  11. Counterintuitive electron localisation from density-functional theory with polarisable solvent models

    Exploration of the solvated electron phenomena using density-functional theory (DFT) generally results in prediction of a localised electron within an induced solvent cavity. However, it is well known that DFT favours highly delocalised charges, rendering the localisation of a solvated electron unexpected. We explore the origins of this counterintuitive behaviour using a model Kevan-structure system. When a polarisable-continuum solvent model is included, it forces electron localisation by introducing a strong energetic bias that favours integer charges. This results in the formation of a large energetic barrier for charge-hopping and can cause the self-consistent field to become trapped in local minima thus converging to stable solutions that are higher in energy than the ground electronic state. Finally, since the bias towards integer charges is caused by the polarisable continuum, these findings will also apply to other classical polarisation corrections, as in combined quantum mechanics and molecular mechanics (QM/MM) methods. The implications for systems beyond the solvated electron, including cationic DNA bases, are discussed

  12. Counterintuitive electron localisation from density-functional theory with polarisable solvent models.

    Dale, Stephen G; Johnson, Erin R

    2015-11-14

    Exploration of the solvated electron phenomena using density-functional theory (DFT) generally results in prediction of a localised electron within an induced solvent cavity. However, it is well known that DFT favours highly delocalised charges, rendering the localisation of a solvated electron unexpected. We explore the origins of this counterintuitive behaviour using a model Kevan-structure system. When a polarisable-continuum solvent model is included, it forces electron localisation by introducing a strong energetic bias that favours integer charges. This results in the formation of a large energetic barrier for charge-hopping and can cause the self-consistent field to become trapped in local minima thus converging to stable solutions that are higher in energy than the ground electronic state. Finally, since the bias towards integer charges is caused by the polarisable continuum, these findings will also apply to other classical polarisation corrections, as in combined quantum mechanics and molecular mechanics (QM/MM) methods. The implications for systems beyond the solvated electron, including cationic DNA bases, are discussed. PMID:26567651

  13. An Autonomous Wearable System for Predicting and Detecting Localised Muscle Fatigue

    Martin Colley

    2011-01-01

    Full Text Available Muscle fatigue is an established area of research and various types of muscle fatigue have been clinically investigated in order to fully understand the condition. This paper demonstrates a non-invasive technique used to automate the fatigue detection and prediction process. The system utilises the clinical aspects such as kinematics and surface electromyography (sEMG of an athlete during isometric contractions. Various signal analysis methods are used illustrating their applicability in real-time settings. This demonstrated system can be used in sports scenarios to promote muscle growth/performance or prevent injury. To date, research on localised muscle fatigue focuses on the clinical side and lacks the implementation for detecting/predicting localised muscle fatigue using an autonomous system. Results show that automating the process of localised muscle fatigue detection/prediction is promising. The autonomous fatigue system was tested on five individuals showing 90.37% accuracy on average of correct classification and an error of 4.35% in predicting the time to when fatigue will onset.

  14. Counterintuitive electron localisation from density-functional theory with polarisable solvent models

    Dale, Stephen G., E-mail: sdale@ucmerced.edu [Chemistry and Chemical Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, California 95343 (United States); Johnson, Erin R., E-mail: erin.johnson@dal.ca [Department of Chemistry, Dalhousie University, 6274 Coburg Road, Halifax, Nova Scotia B3H 4R2 (Canada)

    2015-11-14

    Exploration of the solvated electron phenomena using density-functional theory (DFT) generally results in prediction of a localised electron within an induced solvent cavity. However, it is well known that DFT favours highly delocalised charges, rendering the localisation of a solvated electron unexpected. We explore the origins of this counterintuitive behaviour using a model Kevan-structure system. When a polarisable-continuum solvent model is included, it forces electron localisation by introducing a strong energetic bias that favours integer charges. This results in the formation of a large energetic barrier for charge-hopping and can cause the self-consistent field to become trapped in local minima thus converging to stable solutions that are higher in energy than the ground electronic state. Finally, since the bias towards integer charges is caused by the polarisable continuum, these findings will also apply to other classical polarisation corrections, as in combined quantum mechanics and molecular mechanics (QM/MM) methods. The implications for systems beyond the solvated electron, including cationic DNA bases, are discussed.

  15. Illumination-invariant image matching for autonomous UAV localisation based on optical sensing

    Wan, Xue; Liu, Jianguo; Yan, Hongshi; Morgan, Gareth L. K.

    2016-09-01

    This paper presents an UAV (Unmanned Aerial Vehicle) localisation algorithm for its autonomous navigation based on matching between on-board UAV image sequences to a pre-installed reference satellite image. As the UAV images and the reference image are not necessarily taken under the same illumination condition, illumination-invariant image matching is essential. Based on the investigation of illumination-invariant property of Phase Correlation (PC) via mathematical derivation and experiments, we propose a PC based fast and robust illumination-invariant localisation algorithm for UAV navigation. The algorithm accurately determines the current UAV position as well as the next UAV position even the illumination condition of UAV on-board images is different from the reference satellite image. A Dirac delta function based registration quality assessment together with a risk alarming criterion is introduced to enable the UAV to perform self-correction in case the UAV deviates from the planned route. UAV navigation experiments using simulated terrain shading images and remote sensing images have demonstrated a robust high performance of the proposed PC based localisation algorithm under very different illumination conditions resulted from solar motion. The superiority of the algorithm, in comparison with two other widely used image matching algorithms, MI (Mutual Information) and NCC (Normalised Correlation Coefficient), is significant for its high matching accuracy and fast processing speed.

  16. Quantitative Evaluation of Stereo Visual Odometry for Autonomous Vessel Localisation in Inland Waterway Sensing Applications

    Thomas Kriechbaumer

    2015-12-01

    Full Text Available Autonomous survey vessels can increase the efficiency and availability of wide-area river environment surveying as a tool for environment protection and conservation. A key challenge is the accurate localisation of the vessel, where bank-side vegetation or urban settlement preclude the conventional use of line-of-sight global navigation satellite systems (GNSS. In this paper, we evaluate unaided visual odometry, via an on-board stereo camera rig attached to the survey vessel, as a novel, low-cost localisation strategy. Feature-based and appearance-based visual odometry algorithms are implemented on a six degrees of freedom platform operating under guided motion, but stochastic variation in yaw, pitch and roll. Evaluation is based on a 663 m-long trajectory (>15,000 image frames and statistical error analysis against ground truth position from a target tracking tachymeter integrating electronic distance and angular measurements. The position error of the feature-based technique (mean of ±0.067 m is three times smaller than that of the appearance-based algorithm. From multi-variable statistical regression, we are able to attribute this error to the depth of tracked features from the camera in the scene and variations in platform yaw. Our findings inform effective strategies to enhance stereo visual localisation for the specific application of river monitoring.

  17. Performance characteristics of a polyethylene collimator with an EJ-426 detector in neutron source localisation

    Gamage, K.A.A., E-mail: k.gamage@lancaster.ac.uk; Crompton, A.J.; Joyce, M.J.

    2014-08-01

    In this paper, characteristics of neutron source localisation using an EJ-426 detector with a polyethylene collimator are presented. The detector is placed inside of the polyethylene collimator, where the collimator has a constant internal diameter and external diameter gradually increases towards the back end. The combined detector-collimator unit was mounted onto an equatorial mount and, data were collected from an ultra-fast mixed-field analyser. Neutron images have been produced to characterise the area investigated in real-time. Radiation images are fundamentally related to the detector efficiency and to the collimator geometry. In order to characterise the neutron source localisation capability of the polyethylene collimator, with an EJ-426 detector, experiments have been carried out using three different neutron sources. Results indicate that the existing design of the polyethylene collimator is suitable for localisation of low energy neutron sources. The measurements were performed in the low-scatter facility of the Neutron Metrology, National Physical Laboratory, Teddington, UK.

  18. Análisis de accidentes severos en contenciones nucleares

    Goicolea Ruigómez, José María

    1992-04-01

    Full Text Available Analysis for severe accidents has recently been added to the long list of requisites imposed on nuclear power plants. In this work we study the rationale and justiflcation for this type of analysis. Calculations for the structural response of the containment buildings can be performed on the computer using advanced nonlinear Finite Element codes. A state of the art review of these methods is carried out, proposing a methodology based on analysis by numerical methods with experimental validation. Additionally we present some results obtained by the authors for the analysis of both reinforced concrete and steel containments. The concluding remarks show the validity of the proposed methodology, as well as the evidence of a large security margin in the containments, due mainly to the conservatisms in the design stage.

    El análisis frente a accidentes severos ha venido a añadirse recientemente a la larga lista de requisitos impuestos a las centrales nucleares. En este trabajo se pretende estudiar la problemática y justificación de este tipo de análisis. El cálculo de la respuesta de la contención se puede realizar en el ordenador mediante métodos avanzados de elementos finitos no lineales. Se hace una revisión del estado de la técnica en estos métodos, proponiendo una metodología basada en el análisis mediante modelos numéricos con validación experimental. Se presentan asimismo los resultados de análisis realizados, para contenciones tanto de hormigón armado como metálicas. Las conclusiones del trabajo establecen la validez de la metodología empleada, así como la constatación de un amplio margen de seguridad existente en las contenciones evaluadas, debido a los conservadurismos del proceso de diseño original.

  19. Photoletter to the editor: Dermatitis herpetiformis co-localised with vitiligo in a patient with autoimmune polyglandular syndrome

    Macbeth, Abby E.; Lee, Kevin Y. C.; Levell, Nick J.; Igali, Laszlo; Millington, George W.M.

    2013-01-01

    We report a case of dermatitis herpetiformis co-localised with segmental vitiligo in a 37-year-old woman with a background history of autoimmune polyglandular syndrome type 2. We propose genetic mosaicism as a possible mechanism. There has only been one previous case report in which dermatitis hepetiformis co-localised in close proximity but not exclusively within vilitigo in a patient with autoimmune thyroiditis. To our knowledge, this is the first case report of dermatitis herpetiformis co-...

  20. Development of a prototype of the tele-localisation system in radiotherapy using personal digital assistant via wireless communication

    In localisation of radiotherapy treatment field, the oncologist is present at the simulator to approve treatment details produced by the therapist. Problems may arise if the oncologist is not available and the patient requires urgent treatment. The development of a tele-localisation system is a potential solution, where the oncologist uses a personal digital assistant (PDA) to localise the treatment field on the image sent from the simulator through wireless communication and returns the information to the therapist after his or her approval. Our team developed the first tele-localisation prototype, which consisted of a server workstation (simulator) for the administration of digital imaging and communication in medicine localisation images including viewing and communication with the PDA via a Wi-Fi network; a PDA (oncologist's site) installed with the custom-built programme that synchronises with the server workstation and performs treatment field editing. Trial tests on accuracy and speed of the prototype system were conducted on 30 subjects with the treatment regions covering the neck, skull, chest and pelvis. The average time required in performing the localisation using the PDA was less than 1.5 min, with the blocked field longer than the open field. The transmission speed of the four treatment regions was similar. The average physical distortion of the images was within 4.4% and the accuracy of field size indication was within 5.3%. Compared with the manual method, the tele-localisation system presented with an average deviation of 5.5%. The prototype system fulfilled the planned objectives of tele-localisation procedure with reasonable speed and accuracy.

  1. Pre-treatment nomogram for biochemical control after neoadjuvant androgen deprivation and radical radiotherapy for clinically localised prostate cancer

    Parker, C C; Norman, A R; Huddart, R A; Horwich, A; Dearnaley, D P

    2002-01-01

    Phase III studies have demonstrated the clinical benefit of adding neo-adjuvant androgen deprivation to radical radiotherapy for clinically localised prostate cancer. We have developed a nomogram to describe the probability of PSA control for patients treated in this way. Five hundred and seventeen men with clinically localised prostate cancer were treated with 3–6 months of neo-adjuvant androgen deprivation and radical radiotherapy (64 Gy in 32#) between 1988 and 1998. Median presenting PSA ...

  2. CRITICAL RESOURCE DIMENSIONS FOR DEVELOPMENT OF PATENTS — AN ANALYSIS OF 131 NEW TECHNOLOGY-BASED FIRMS LOCALISED IN INCUBATORS

    HANS LÖFSTEN

    2015-01-01

    The purpose of this study is to analyse critical resource dimensions for development of patents for these new technology-based firms. The empirical base is 131 new technology-based firms in five high-tech industries: Software/information technology, technology consultants, electronics/electrical, pharmacology and pharmaceutical preparation and mechanics, localised on 16 incubators in Sweden. The incubators in this study are all affiliated to a university. The 131 localised new technology-base...

  3. Accidentes de trabajo fatales y violencia interpersonal en Brasil, 2000-2010

    Vilma Sousa Santana

    2013-01-01

    Full Text Available En el presente estudio se estima la mortalidad proporcional por accidentes de trabajo provocados por violencia interpersonal en Brasil, entre 2000 y 2010. Se analizaron los datos del Sistema de Información sobre Mortalidad, basados en los informes estadísti- cos de defunción del Ministerio de Salud de Brasil, los cuales incluyen un campo para el registro de accidentes de trabajo que debe ser completado en toda defunción por causas externas. Se identificaron 1.368.732 casos de defunciones por causas externas, 31.576 (2,3% por accidentes de trabajo y solo 226 (0,02% por accidentes de trabajo con violen- cia interpersonal. Cerca del 80% de los informes estadísticos de defunción no tenían el campo “accidente de trabajo” completado. La mayor cantidad de casos ocurrió entre hom- bres (94,3% de 25-34 años, con nivel de escolaridad medio, ubicados en la región sudeste y noreste, que trabajan principalmente en la producción de bienes y servicios industriales y la actividad agropecuaria. La mayoría de los casos fueron causados por armas de fuego, seguidos por armas blancas, con un aumento relativo de estos últimos en el período estu- diado. Los resultados sugieren un gran subregistro de diagnósticos que reconocen la rela- ción con el trabajo. Se hace necesaria una mejor capacitación en el llenado de los informes estadísticos, así como estudios que cuantifiquen el subregistro de accidentes de trabajo y accidentes de trabajo con violencia interpersonal.

  4. Carcinoma of the breast wire localisation post nuclear medicine sentinel lymph node imaging. Are radiologists receiving a significant dose?

    Meades, R.T.; Frank, J.W.; Gada, V.; Ralleigh, G.; Satchithananda, K.; Barrett, N.; Nijran, K.S. [Imperial College Healthcare NHS Trust, London (United Kingdom); Svensson, W.E. [Imperial College Healthcare NHS Trust, London (United Kingdom); Charing Cross Hospital, Department of Nuclear Medicine, London (United Kingdom)

    2010-03-15

    To assess the radiation dose received by the radiologist when performing wire localisation for axillary radio-isotope sentinel node imaging-guided biopsy in patients with impalpable breast cancers treated with breast-preserving excision. When wire placement follows radio-isotope sentinel node imaging (RSNI) the radiologist is exposed to a radiation risk that has never been previously assessed. Radiation doses to radiologists performing ultrasound-guided localisation following nuclear medicine sentinel node imaging were measured for procedures on the day of surgery (20 MBq) and also on the day before surgery (40 MBq). These measurements were compared with theoretically calculated doses. Twelve patients showed comparable results between measurements and estimated doses. The mean measured dose was 1.8{mu}Sv (estimated 1.8{mu}Sv) for same-day and 4.8{mu}Sv (estimated 3.4{mu}Sv) for next-day surgery cases. At worst, radiologists who perform 36 wire localisations per year immediately following RSNI receive a radiation dose of 0.17 mSv. This study highlights the need to inform radiologists of the relative risk when performing pre-surgical localisation after RSNI. This risk should be justified locally in accordance with the total dose received by the localising radiologist. Particular consideration should be given to pregnant staff and the possibility of performing wire localisations before radio-isotope injection. (orig.)

  5. Doctrinal elements for the post-accidental management of a nuclear accident - Final version

    This report examines and defines the objectives, principles and main actions for the post-accidental management of a nuclear accident. It defines the emergency phase and the post-accidental phase, three basic objectives (to protect the population against the hazards of ionizing radiations, to support populations affected by the accident consequences, to restore affected territories), management principles, key issues for post-accidental management. It defines actions to be undertaken: post-accidental zoning, monitoring of deposited radioactivity, early actions for the protection and taking charge of population, information. It addresses the different aspects of post-accidental management planning in a period of transition: reception of population, reduction of population exposure to deposited radioactivity, treatment of public health problems, improvement of the knowledge on the radiological situation of the environment, improvement of the radiological quality of the different environments, dealing with wastes, empowerment of stakeholders through an adequate governance, support and redeployment of economic activity, help and compensation, information. Appendices more deeply discuss actions to be undertaken just after the emergency phase, for the management of the transition period, and for the management of the long-term period

  6. Patterns and Trends in Accidental Poisoning Deaths: Pennsylvania’s Experience 1979-2014

    Balmert, Lauren C.; Buchanich, Jeanine M.; Pringle, Janice L.; Williams, Karl E.; Burke, Donald S.; Marsh, Gary M.

    2016-01-01

    Introduction The purpose of this study was to examine county and state-level accidental poisoning mortality trends in Pennsylvania from 1979 to 2014. Methods Crude and age-adjusted death rates were formed for age group, race, sex, and county for accidental poisonings (ICD 10 codes X40-X49) from 1979 to 2014 for ages 15+ using the Mortality and Population Data System housed at the University of Pittsburgh. Rate ratios were calculated comparing rates from 1979 to 2014, overall and by sex, age group, and race. Joinpoint regression was used to detect statistically significant changes in trends of age-adjusted mortality rates. Results Rate ratios for accidental poisoning mortality in Pennsylvania increased more than 14-fold from 1979 to 2014. The largest rate ratios were among 35–44 year olds, females, and White adults. The highest accidental poisoning mortality rates were found in the counties of Southwestern Pennsylvania, those surrounding Philadelphia, and those in Northeast Pennsylvania near Scranton. Conclusions The patterns and locations of accidental poisoning mortality by race, sex, and age group provide direction for interventions and policy makers. In particular, this study found the highest rate ratios in PA among females, whites, and the age group 35–44. PMID:26963396

  7. Fate of accidental symmetries of the relativistic hydrogen atom in a spherical cavity

    Al-Hashimi, M. H.; Shalaby, A. M.; Wiese, U.-J.

    2015-11-01

    The non-relativistic hydrogen atom enjoys an accidental SO(4) symmetry, that enlarges the rotational SO(3) symmetry, by extending the angular momentum algebra with the Runge-Lenz vector. In the relativistic hydrogen atom the accidental symmetry is partially lifted. Due to the Johnson-Lippmann operator, which commutes with the Dirac Hamiltonian, some degeneracy remains. When the non-relativistic hydrogen atom is put in a spherical cavity of radius R with perfectly reflecting Robin boundary conditions, characterized by a self-adjoint extension parameter γ, in general the accidental SO(4) symmetry is lifted. However, for R =(l + 1) (l + 2) a (where a is the Bohr radius and l is the orbital angular momentum) some degeneracy remains when γ = ∞ or γ =2/R. In the relativistic case, we consider the most general spherically and parity invariant boundary condition, which is characterized by a self-adjoint extension parameter. In this case, the remnant accidental symmetry is always lifted in a finite volume. We also investigate the accidental symmetry in the context of the Pauli equation, which sheds light on the proper non-relativistic treatment including spin. In that case, again some degeneracy remains for specific values of R and γ.

  8. Accidental Dark Matter: Case in the Scale Invariant Local $B-L$ Model

    Guo, Jun; Ko, P; Orikasa, Yuta

    2015-01-01

    We explore the idea of accidental dark matter (aDM) stability in the scale invariant local $U(1)_{B-L}$ model, which is a theory for neutrino and at the same time radiatively breaks scale invariance via quantum mechanical dynamics in the $U(1)_{B-L}$ sector. A real singlet scalar can be accidental DM with an accidental $Z_2$, by virtue of both extended symmetries. A $U(1)_{B-L}$ charged complex scalar can also be a viable accidental DM due to an accidental (or remanent) $Z_3$. They can reproduce correct relic density via the annihilations through the conventional Higgs portal or dark Higgs portal. The dark Higgs portal scenario is in tension with the LHC bound on $Z_{B-L}$, and only heavy DM of a few TeVs can have correct relic density. In particular, DM may trigger spontaneous breaking of scale Invariance (SISB). The situation is relaxed significantly in the $Z_3$ case due to the effective semi-annihilation mode and then light DM can be accommodated easily. In addition, the $Z_3$ model can accommodate the Ge...

  9. Patterns and Trends in Accidental Poisoning Deaths: Pennsylvania's Experience 1979-2014.

    Lauren C Balmert

    Full Text Available The purpose of this study was to examine county and state-level accidental poisoning mortality trends in Pennsylvania from 1979 to 2014.Crude and age-adjusted death rates were formed for age group, race, sex, and county for accidental poisonings (ICD 10 codes X40-X49 from 1979 to 2014 for ages 15+ using the Mortality and Population Data System housed at the University of Pittsburgh. Rate ratios were calculated comparing rates from 1979 to 2014, overall and by sex, age group, and race. Joinpoint regression was used to detect statistically significant changes in trends of age-adjusted mortality rates.Rate ratios for accidental poisoning mortality in Pennsylvania increased more than 14-fold from 1979 to 2014. The largest rate ratios were among 35-44 year olds, females, and White adults. The highest accidental poisoning mortality rates were found in the counties of Southwestern Pennsylvania, those surrounding Philadelphia, and those in Northeast Pennsylvania near Scranton.The patterns and locations of accidental poisoning mortality by race, sex, and age group provide direction for interventions and policy makers. In particular, this study found the highest rate ratios in PA among females, whites, and the age group 35-44.

  10. Food irradiation

    Food treatment by means of ionizing energy, or irradiation, is an innovative method for its preservation. In order to treat important volumes of food, it is necessary to have industrial irradiation installations. The effect of radiations on food is analyzed in the present special work and a calculus scheme for an Irradiation Plant is proposed, discussing different aspects related to its project and design: ionizing radiation sources, adequate civil work, security and auxiliary systems to the installations, dosimetric methods and financing evaluation methods of the project. Finally, the conceptual design and calculus of an irradiation industrial plant of tubercles is made, based on the actual needs of a specific agricultural zone of our country. (Author)

  11. Fruits irradiation

    The objectives of this project in food irradiation are two-fold, to study the effect of irradiation in prolongation of useful storage life of fruits and to evaluate irradiation as a means of preserving fruits. However radiation is not intended to replace existing preservation processes but may be used in conjunction with current methods such as refrigeration, drying, fermentation etc. In fact radiation should combine with proper storage and packaging techniques in order to ensure maximum benefits. Ripening retardation of fruits by irradiation kinds of fruits: papaya, mango, rambutan, longan and durian. Changes in organoleptic properties of fruit flavor and taste, texture changes by taste panel estimation of significance level of results by statistical mathematical methods, chemical changes determination of climacteric peak in fruits by estimation of carbon dioxide evolution, vitamin C determination by Tillmann's method, carotenoid separation by thin layer chromatography, reducing sugars and acidity determination, volatile components of durian by gas-chromatography

  12. Food irradiation

    The preservation of food using irradiation may replace or be used in combination with traditional or conventional food preservation techniques. Studies have shown that the irradiation technique which uses less energy than other preservation methods is a potential way for reducing post harvest losses. However, economic feasibility among other constraints is the core factor to determine the success of the technique at commercial scale. The need and importance for considering this new technique in Malaysia are discussed here. (author)

  13. Tratamiento de Terapia Ocupacional en el accidente cerebrovascular

    Domingo García, AM

    2006-02-01

    Full Text Available RESUMENEntre los muchos pacientes que necesitan tratamiento rehabilitador en Terapia Ocupacional están los que en la edad adulta han sufrido un accidente cerebrovascular.Uno de los factores de riesgo asociados con más frecuencia a las alteraciones del sistema nervioso central es el progresivo envejecimiento de la población, debido a esto orientaré el siguiente artículo hacia la intervención sobre la población geriátrica.La Terapia Ocupacional ofrece un tratamiento global que abarca las áreas funcional, motriz, sensorial, perceptivo y cognitiva. No debemos olvidar el asesoramiento realizado al paciente, a la familia y/ o cuidadores sobre el manejo de la persona que ha sufrido un ictus, la adaptación del entorno y la prescripción, uso y manejo de ayudas técnicas cuando sea necesario.Las propuestas terapéuticas que expondré a continuación, no son recetas únicas que se puedan emplear del mismo modo en todos las personas que hayan sufrido un ictus. Con cada paciente será necesario una evaluación individualizada de su situación y una adaptación de la terapia según sus déficit específicos.La meta final de la Terapia Ocupacional es la integración óptima del paciente dentro de su entorno familiar y social, con el mayor grado de autonomía posible.ABSTRACTAmong the patients who need Occupational Therapy’s rehabilitation treatment, there are those who have suffered a cerebrovascular damage when elderly.People’s gradual ageing is one of the risk factors in the nervous central system’s alterations and this is why I am going to write about intervention on geriatric population.The Occupational Therapy’s rehabilitation treatment works on the functional, motor, sensorial, perceptive and cognitive areas. Moreover, we should not forget to advise the patient and his/her family or caregivers about the way of treating ,the environment’s adaptation, the prescription and use of technical aids when needed.The following therapeutic

  14. Food irradiation

    A worldwide standard on food irradiation was adopted in 1983 by codex Alimentarius Commission of the Joint Food Standard Programme of the Food and Agriculture Organization (FAO) of the United Nations and The World Health Organization (WHO). As a result, 41 countries have approved the use of irradiation for treating one or more food items and the number is increasing. Generally, irradiation is used to: food loses, food spoilage, disinfestation, safety and hygiene. The number of countries which use irradiation for processing food for commercial purposes has been increasing steadily from 19 in 1987 to 33 today. In the frames of the national programme on the application of irradiation for food preservation and hygienization an experimental plant for electron beam processing has been established in Inst. of Nuclear Chemistry and Technology. The plant is equipped with a small research accelerator Pilot (19 MeV, 1 kW) and industrial unit Electronika (10 MeV, 10 kW). On the basis of the research there were performed at different scientific institutions in Poland, health authorities have issued permissions for irradiation for; spices, garlic, onions, mushrooms, potatoes, dry mushrooms and vegetables. (author)

  15. Insomnia medication use and the probability of an accidental event in an older adult population

    Alon Y Avidan

    2010-11-01

    Full Text Available Alon Y Avidan1, Liisa A Palmer2, Justin F Doan3, Robert W Baran31UCLA Department of Neurology, Los Angeles, CA, USA; 2Thomson Reuters, Washington, DC, USA; 3Takeda Global Research and Development Center, Deerfield, IL, USAObjective: This study examined the risk of accidental events in older adults prescribed a sedating antidepressant, long-acting benzodiazepine, short-acting benzodiazepine, and nonbenzodiazepine, relative to a reference group (selective melatonin receptor agonist.Methods: This was a retrospective cohort analysis of older adults (≥65 years with newly initiated pharmacological treatment of insomnia. Data were collected from the Thomson MarketScan® Medicare Supplemental and Coordination of Benefits databases (January 1, 2000, through June 30, 2006. Probit models were used to evaluate the probability of an accidental event.Results: Data were analyzed for 445,329 patients. Patients taking a long-acting benzodiazepine (1.21 odds ratio [OR], short-acting benzodiazepine (1.16 OR, or nonbenzodiazepine (1.12 OR had a significantly higher probability of experiencing an accidental event during the first month following treatment initiation compared with patients taking the reference medication (P < 0.05 for all. A significantly higher probability of experiencing an accidental event was also observed during the 3-month period following the initiation of treatment (1.62 long-acting benzodiazepine, 1.60 short-acting benzodiazepine, 1.48 nonbenzodiazepine, and 1.56 sedating antidepressant; P < 0.05.Conclusions: Older adults taking an SAD or any of the benzodiazepine receptor agonists appear to have a greater risk of an accidental event compared with a reference group taking an MR.Keywords: insomnia, accidental events, benzodiazepine receptor agonist, melatonin receptor agonist, older adults

  16. Comparison of intracranial computed tomographic (CT) findings in pediatric abusive and accidental head trauma

    Background. Child abuse specialists rely heavily on diagnostic neuroimaging. Objectives. Study objectives were: (1) to compare the frequencies of six specific intracranial CT abnormalities in accidental and non-accidental pediatric head trauma, and (2) to assess interobserver agreement regarding these CT findings. Materials and methods. Three pediatric radiologists blindly and independently reviewed cranial CT scans of pediatric patients who sustained closed head trauma between 1991 and 1994. All patients were less than 4 years of age. Study cases included thirty-nine (50 %) with non-accidental head trauma and thirty-nine (50 %) with accidental head trauma. Each scan was evaluated for the presence or absence of the following six intracranial findings: (1) interhemispheric falx hemorrhage, (2) subdural hemorrhage, (3) large (non-acute) extra-axial fluid, (4) basal ganglia edema, (5) posterior fossa hemorrhage, and (6) frontal-parietal shearing tear(s). Interobserver agreement was calculated as the percentage of total cases in which all reviewers agreed a specific CT finding was present or absent. Diagnosis required independent agreement by all three pediatric radiologists. The frequencies of these six intracranial CT abnormalities were compared between the two study groups by Chi-square analysis and Fisher's exact test. Results. Interobserver agreement between radiologists was greater than 80 % for all lesions evaluated, with the exception of frontal-parietal shearing tear(s). Interhemispheric falx hemorrhage, subdural hemorrhage, large (non-acute) extra-axial fluid, and basal ganglia edema were discovered significantly more frequently in non-accidental trauma (P ≤.05). Conclusion. Although not specific for child abuse, discovery of these intracranial CT abnormalities in young patients should prompt careful evaluation of family and injury circumstances for indicators of non-accidental trauma. (orig.). With 6 figs., 2 tabs

  17. Investigation of Thermal Equilibrium around an Accidental Event and Impact on Possibly Enclosed Surrounding Environment

    Sarkar, Biswanath; Shah, Nitin; Choukekar, Ketan; Kapoor, Himanshu; Kumar, Uday; Das, Jotirmoy; Bhattacharaya, Ritendra; Vaghela, Hitensinh; Muralidhara, Srinivasa

    Complex and large cryogenic distribution systems are integral part of a fusion machine having superconducting magnets, cryopumps, etc. The various equipment of the cryogenic distribution system are interconnected via Cryogenic Transfer Lines (CTLs) to distribute cold helium to end users. During nominal operation of the fusion machine, helium inventory in CTLs could be in order of several tons. The cold helium present in CTLs could be released in surrounding volume due to accidental scenario. The present analysis, aims to estimate lowest temperature in the surrounding volume due to accidental scenario. The paper will describe simulation results and the test plan in a simulated condition.

  18. Inhaled Surfactant in the treatment of accidental Talc Powder inhalation: a new case report

    Lo Piparo Caterina

    2011-09-01

    Full Text Available Abstract The use of talcum powder is incorrectly part of the traditional care of infants. Its acute aspiration is a very dangerous condition in childhood. Although the use of baby powder has been discouraged from many authors and the reports of its accidental inhalation have been ever more rare, sometimes new cases with several fatalities have been reported. We report on a patient in which accidental inhalation of baby powder induced severe respiratory difficulties. We also point out the benefits of surfactant administration. Surfactant contributed to the rapid improvement of the medical and radiological condition, preventing severe early and late complications and avoiding invasive approaches.

  19. La responsabilidad civil por los daños sufridos en un accidente de trabajo

    San José Sebrango, Marta

    2015-01-01

    RESUMEN: La preocupación por la siniestralidad laboral obliga al legislador a introducir constantes cambios con objeto de tratar de evitar accidentes o, al menos disminuirlos, con el fin de mejorar no solo la calidad de vida de los trabajadores, sino la calidad en el desempeño del trabajo, evitando situaciones gravosas o penosas por la especialización y mejoras reguladas, entre otras, en la Ley de Prevención de Riesgos Laborales. Sin embargo, es inevitable que los accidentes de trabajo se ...

  20. Accidentes de trabajo fatales y violencia interpersonal en Brasil, 2000-2010

    Vilma Sousa Santana; Elizabeth Costa Dias; Graziella Lage Oliveira; Maria Cláudia Peres Moura; Leticia Coelho da Costa Nobre; Jorge Mesquita Huet Machado

    2013-01-01

    En el presente estudio se estima la mortalidad proporcional por accidentes de trabajo provocados por violencia interpersonal en Brasil, entre 2000 y 2010. Se analizaron los datos del Sistema de Información sobre Mortalidad, basados en los informes estadísti- cos de defunción del Ministerio de Salud de Brasil, los cuales incluyen un campo para el registro de accidentes de trabajo que debe ser completado en toda defunción por causas externas. Se identificaron 1.368.732 casos de defunciones por ...

  1. Cuidados de Enfermería en el Accidente Ofídico

    Lorenzo Hernández, María Piedad; Hernández Cano, Rosa María; Soria Suárez, María Isabel

    2013-01-01

    El accidente ofídico supone una emergencia médica que requiere atención médica inmediata, pudiendo provocar la muerte de no realizarse una actuación adecuada precoz. El tratamiento varía según la geografía y características de las serpientes autóctonas, existiendo múltiples protocolos, que en ocasiones resultan contradictorios. El objetivo de este trabajo es realizar el proceso de atención de enfermería en el accidente ofídico, siendo imprescindible poseer un conocimiento integral de las e...

  2. Laryngeal impaction of an archwire segment after accidental ingestion during orthodontic adjustment.

    Umesan, Uday Kumar; Ahmad, Wizziyiane; Balakrishnan, Priya

    2012-08-01

    Orthodontic archwires or fractured appliances that are accidentally swallowed can become lodged in the airway or gastrointestinal tract. Inadvertent ingestion or aspiration of an appliance or archwire piece during orthodontic appliance adjustment is a medical emergency with potentially serious complications, including possible death from asphyxiation. This article reports the accidental ingestion of a piece of orthodontic archwire that became impacted in the larynx; it was subsequently retrieved. Some potential complications are discussed, along with suggested precautions to prevent such mishaps when using fixed appliances. PMID:22858337

  3. A tunnel shape defect on maxillary bone after accidental injection of formocresol instead of anesthetic solution.

    Ege, Bilal; Demirkol, Mehmet; Mustafa, Rawand; Aras, Mutan Hamdi

    2014-09-01

    Accidental injection or leakages of various chemical disinfectants used during root canal preparation into adjacent tissues have been shown to have deleterious effects on surrounding tissue. Formocresol (FC) is an effective intracanal disinfectant used in endodontic procedures. However, it is known to have harmful effects into adjacent tissues. The aim of this article is to present an unusual case in which a 28-year-old male patient developed gingival and bone necrosis after the accidental injection of FC instead of local anesthetic solution for tooth extraction and to review cases in the literature where complications have occurred due to the use of FC. PMID:25148635

  4. Drogodependencias, conducción y accidentes de tráfico

    Cano Pérez, L.; Osca-Lluch, Julia; Haba Osca, Julia

    2010-01-01

    Los accidentes de tráfico suponen una causa importante de mortalidad, morbilidad y discapacidad. El uso y abuso de alcohol y drogas en los contextos recreativos nocturnos es frecuente y esta muy relacionado con los accidentes de tráfico. El consumo de drogas y la conducción bajo los efectos del alcohol, sin necesidad de efectuarse bajo un efecto de embriaguez, es uno de los grandes problemas que aparecen en el área de la seguridad vial.

  5. Commercial irradiator

    Commercial irradiation, the treatment of products with gamma radiation principally using a Cobalt-60 source, had its beginnings in Europe and Australia 25 years ago. To date the most successful application of the process is the sterilization of medical products and, for a variety of reasons, gamma sterilization is now becoming dominant in this important field. Many other applications have been evaluated over the years and the most exciting is undoubtedly food irradiation for which there is a vast potential. The commercial feasibility of setting up and irradiation facility is a complex subject and the selection of Cobalt-60 gamma plant depends on a number of technical and economic considerations. The parameters which determine the design and capacity of the optimum plant include throughput, product size and dose requirements; a balance has to be struck between plant flexibility and overall economy. The Ansell irradiators are designed primarily for the sterilization of medical products although some experimental food irradiation has been done, particularly in Australia. (author)

  6. Localisation of sentinel lymph nodes: Will it influence the management of penis carcinoma?

    Aim: Patients in developing countries often present with advanced penis carcinoma and palpable inguinal lymph nodes. Since secondary infection is almost invariably present, distinguishing clinically between reactive nodes and metastasis can be difficult. The aim of our study was to evaluate dynamic sentinel node localisation for the detection of inguinal metastases in patients with penile carcinoma, in order to avoid the morbidity of full inguinal block dissection. Material and Methods: Patients with penis carcinoma presenting at the Department of Urology were included in the study. All patients underwent a scintigraphic sentinel node localisation procedure one day prior to surgery. Blue dye was injected immediately prior to surgery. Aided by a gamma probe and/or by visualising a blue node, the sentinel nodes were identified and removed. In patients with a small, well differentiated primary lesion and non-palpable nodes only the sentinel nodes were removed. In those with locally advanced or poorly differentiated primary lesions and/or clinically palpable nodes, a full inguinal block dissection was performed immediately after sentinel node biopsy and penectomy. Results: Seventeen patients with a mean age of 55 years (range 33-83 years) were included in the study. Sentinel nodes were detected bilaterally in ten patients and unilaterally in six. In one patient no sentinel node could be detected scintigraphically. Tumour involvement of sentinel nodes was found in only 1 patient, in whom malignancy was also found in other ipsilateral nodes removed at block dissection. In two patients the sentinel nodes were tumour negative, but metastases were shown in other inguinal nodes removed at block dissection. Conclusion: In this evaluation dynamic sentinel lymph node localisation followed by immediate inguinal block dissection was true positive in 1 and false negative in 2 of 17 patients with penile carcinoma. Further study and follow-up is required before routine use of the

  7. EphB4 localises to the nucleus of prostate cancer cells

    Mertens-Walker, Inga, E-mail: inga.mertenswalker@qut.edu.au [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Australian Prostate Cancer Research Centre—Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba 4102, QLD (Australia); Lisle, Jessica E. [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Australian Prostate Cancer Research Centre—Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba 4102, QLD (Australia); Nyberg, William A. [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Stephens, Carson R. [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Australian Prostate Cancer Research Centre—Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba 4102, QLD (Australia); Burke, Leslie [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Rutkowski, Raphael; Herington, Adrian C.; Stephenson, Sally-Anne [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Australian Prostate Cancer Research Centre—Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba 4102, QLD (Australia)

    2015-04-10

    The EphB4 receptor tyrosine kinase is over-expressed in a variety of different epithelial cancers including prostate where it has been shown to be involved in survival, migration and angiogenesis. We report here that EphB4 also resides in the nucleus of prostate cancer cell lines. We used in silico methods to identify a bipartite nuclear localisation signal (NLS) in the extracellular domain and a monopartite NLS sequence in the intracellular kinase domain of EphB4. To determine whether both putative NLS sequences were functional, fragments of the EphB4 sequence containing each NLS were cloned to create EphB4NLS-GFP fusion proteins. Localisation of both NLS-GFP proteins to the nuclei of transfected cells was observed, demonstrating that EphB4 contains two functional NLS sequences. Mutation of the key amino residues in both NLS sequences resulted in diminished nuclear accumulation. As nuclear translocation is often dependent on importins we confirmed that EphB4 and importin-α can interact. To assess if nuclear EphB4 could be implicated in gene regulatory functions potential EphB4-binding genomic loci were identified using chromatin immunoprecipitation and Lef1 was confirmed as a potential target of EphB4-mediated gene regulation. These novel findings add further complexity to the biology of this important cancer-associated receptor. - Highlights: • The EphB4 protein can be found in the nucleus of prostate cancer cell lines. • EphB4 contains two functional nuclear localisation signals. • Chromatin immunoprecipitation has identified potential genome sequences to which EphB4 binds. • Lef1 is a confirmed target for EphB4-mediated gene regulation.

  8. EphB4 localises to the nucleus of prostate cancer cells

    The EphB4 receptor tyrosine kinase is over-expressed in a variety of different epithelial cancers including prostate where it has been shown to be involved in survival, migration and angiogenesis. We report here that EphB4 also resides in the nucleus of prostate cancer cell lines. We used in silico methods to identify a bipartite nuclear localisation signal (NLS) in the extracellular domain and a monopartite NLS sequence in the intracellular kinase domain of EphB4. To determine whether both putative NLS sequences were functional, fragments of the EphB4 sequence containing each NLS were cloned to create EphB4NLS-GFP fusion proteins. Localisation of both NLS-GFP proteins to the nuclei of transfected cells was observed, demonstrating that EphB4 contains two functional NLS sequences. Mutation of the key amino residues in both NLS sequences resulted in diminished nuclear accumulation. As nuclear translocation is often dependent on importins we confirmed that EphB4 and importin-α can interact. To assess if nuclear EphB4 could be implicated in gene regulatory functions potential EphB4-binding genomic loci were identified using chromatin immunoprecipitation and Lef1 was confirmed as a potential target of EphB4-mediated gene regulation. These novel findings add further complexity to the biology of this important cancer-associated receptor. - Highlights: • The EphB4 protein can be found in the nucleus of prostate cancer cell lines. • EphB4 contains two functional nuclear localisation signals. • Chromatin immunoprecipitation has identified potential genome sequences to which EphB4 binds. • Lef1 is a confirmed target for EphB4-mediated gene regulation

  9. Radiation safety and accident experience at gamma irradiation plants

    Gamma irradiation plants for the sterilization of medical products, preservation of food grains and for various other applications employ multikilocurie 60Co sealed sources inside shielded irradiation cells. A number of interlocks are provided between the cell entry door and the source raise mechanisms, in order to prevent the entry of any person to the cell when the source is in the exposed condition. The present paper gives the general safety features and the interlocks employed in these plants along with the safety features of irradiation plants at BARC, namely 106 Ci Isomed plant for the sterilization of medical products, 105 Ci FIPLY plant for research in food preservation and 105 Ci PANBIT plant for industrial research. Over the last two decades five cases of accidental exposure have been reported in literature in which the operator gained entry to the irradiation cell when the source was in the exposed condition. Two of these cases resulted in fatalities while the remaining three cases resulted in hospitalization of the exposed individuals for six to seven weeks. A brief outline of these accidental exposure cases and the causes of the accidents are discussed in this paper. (author). 19 refs

  10. Localisation of breast lesions with MR mammography (work-in-progress)

    While working with dynamic MR mammography (MRM) the need for an MR-guided localisation technique became obvious, because certain lesions were only detectable with dynamic MRM. We developed a technique to mark small breast lesions with MR guidance. Contrast-enhanced MRI was performed in a second examination, and with the use of markers on the skin a needle was placed next to the lesion. A charcoal mixture was injected around the lesion. We performed this procedure in five patients. Follow-up examinations have shown that the procedure was successful. (orig.)

  11. Localisation d'un bruit blanc en fonction de son azimut, en ecoute binaurale vs. monaurale

    Mazo, Vincent; Paquier, Mathieu; Carriou, Célia; Jantzem, Brice; Marianovski, Rémi

    2016-01-01

    Lorsque l'information d'une seule oreille est disponible (normo-entendant avec une oreille bouchée ou malentendant atteint d'une cophose unilatérale), seuls les indices monauraux sont disponibles. L'objectif de cette étude était d'observer dans quelle mesure la localisation de sources en azimut, généralement rendue possible par l'exploitation des différences interaurales de temps et de niveau, était possible uniquement grâce à des indices monauraux. Un bruit blanc a été diffusé par différente...

  12. Localised agri-food systems: concept development and diversity of situations

    Muchnik, José

    2010-01-01

    Localised agri-food systems (syal: from the French systèmes agroalimentaires localisés) are a type of organisation of agri-food activities, in which territorial dynamics play a decisive role in terms of the coordination between stakeholders and the development of production activities. The aim of this paper is to analyse: (i) the construction and evolution of the syal concept, (ii) the integrated character of the syal concept and its conceptual basis, (iii) how agri-food activities are linked...

  13. Saturation mechanism in clarinet-like instruments, the effect of the localised non-linear losses

    Atig, Merouane; Dalmont, Jean-Pierre; Gilbert, Joël

    2004-01-01

    The question of what limits the amplitude of the oscillations of clarinet-like instruments is investigated. The study is based on numerical simulations in which two kind of losses are taken into account: linear losses and non-linear losses localised at the open end of the tube. The influence of the amount of losses on the saturation process and on the playing range of clarinet-like instruments is shown. Results are confirmed by experiments using an artificial mouth in which the non-linear los...

  14. Fibre Tip Sensors for Localised Temperature Sensing Based on Rare Earth-Doped Glass Coatings

    Erik P. Schartner

    2014-11-01

    Full Text Available We report the development of a point temperature sensor, based on monitoring upconversion emission from erbium:ytterbium-doped tellurite coatings on the tips of optical fibres. The dip coating technique allows multiple sensors to be fabricated simultaneously, while confining the temperature-sensitive region to a localised region on the end-face of the fibre. The strong response of the rare earth ions to changing temperature allows a resolution of 0.1–0.3 °C to be recorded over the biologically relevant range of temperatures from 23–39 °C.

  15. Conception d'un capteur sonore pour la localisation de source en robotique mobile

    Argentieri, Sylvain

    2006-01-01

    Le système auditif de l'homme fournit de nombreuses informations sur son environnement sonore. Nous sommes par exemple capables de localiser précisément l'origine d'un son et d'en interpréter sa signification, si bien qu'il parait aujourd'hui extrêmement difficile de se passer de ces informations sonores dans un monde dynamique et imprévisible. Pourtant, la robotique mobile n'a que très peu intégré cette modalité auditive, bien qu'elle apparaisse indispensable pour compléter les informations ...

  16. Accidentes ocupacionales y conocimiento sobre precauciones universales en internos universitarios costarricenses

    Álvaro Rivera-Valdivia

    2005-04-01

    Full Text Available Justificación y objetivo: los internos universitarios (estudiantes de medicina en su último año son vulnerables a accidentes ocupacionales con agujas y otros objetos cortantes, especialmente debido a su inexperiencia y falta de entrenamiento aunados a su deseo de realizar una serie de nuevas actividades y procedimientos. No existe información en nuestro país con respecto a la frecuencia de este tipo de accidentes en internos universitarios de la carrera de medicina. El objetivo del presente estudio fue estudiar la frecuencia y tipo de accidentes ocupacionales sufridos con mayor frecuencia por internos de medicina y evaluar su conocimiento sobre precauciones universales. Metodología: Se realizó un estudio descriptivo de corte transversal a través de una encuesta directa y anónima. De todos los internos de medicina que trabajaban en el Valle Central de octubre de 2001 a enero de 2002 se seleccionó una muestra aleatoria de 201 internos (poder 95%, error 5%. A la población seleccionada se le aplicó una encuesta precodificada, la cual consistía en 20 preguntas estructuradas, la mayoría cerradas y tres abiertas relacionadas con la ocurrencia de accidentes ocupacionales en los médicos internos, número, tipo, acciones tomadas tras el accidente y conocimientos sobre precauciones universales. Posteriormente se hizo un análisis descriptivo de los resultados obtenidos. Resultados: de todos los participantes, 90% habían trabajado más de 3 meses como médicos internos. Más de la mitad habían realizado al menos 3 meses de rotación en una área médica y 3 meses en una área quirúrgica. La muestra incluyó estudiantes de 5 universidades diferentes. Sólo un 37% de los internos encuestados habían recibido la vacunación contra virus de la hepatitis B. Del total de internos, 64% admitió haber sufrido al menos un accidente ocupacional con sangre de algún paciente, un 20% admitió haber sufrido 3 o 4 accidentes. De los internos que

  17. Vinca irradiator

    The development programme of the VINCA radiosterilisation centre involves plans for an irradiator capable of working in several ways. Discontinuous operation. The irradiator is loaded for a certain period then runs automatically until the moment of unloading. This method is suitable as long as the treatment capacity is relatively small. Continuous operation with permanent batch loading and unloading carried out either manually or automatically (by means of equipment to be installed later). Otherwise the design of the apparatus is highly conventional. The source is a vertical panel submersible in a pool. The conveyor is of the 'bucket' type, with 4 tiers to each bucket. The batches pass successively through all possible irradiation positions. Transfert into and out of the cell take place through a maze, which also provides access to the cell when the sources are in storage at the bottom of the pool

  18. ESR dosimetry using eggshells and tooth enamel for accidental dosimetry

    The CO2- signal of eggshells showed a good dose linearity and was appropriate in the wide dose range from 1 to 10 kGy, while ESR signal of CO2- in sea and fresh water shells were saturated at a dose od below 10 kGy. The minimum detectable dose and G-value of CO2- in eggshells were estimated 0.3 Gy and 0.28, respectively. The lifetime of CO2- in eggshells could not be determined exactly because of overlapping organic signals, however it is still sufficiently long for practical use as ESR dosimeter materials. Various bird's or reptile's eggshells would be available as natural retrospective ESR dosimeter materials after nuclear accidents. Eggshells will be useful for the food irradiation dosimetry in the dose range of about a few kGy. Tooth enamel is one of the most useful dosimeter materials in public at a accident because of its high sensitivity. ESR dosimetry will replace TLD in near future if the cost of an ESR reader is further reduced . (author)

  19. INPR ACPR utilization in fuel behaviour studies under accidental condition

    Negut, Gheorghe; Popov, Mircea [Institute for Nuclear Power Reactors, Pitesti (Romania)

    1990-07-01

    This paper is dedicated to the experimental program, investigating CANDU type fuel behaviour in transient condition, as well as the facilities supporting this program. The tests Reactivity Initiated Accident type. The experiments were performed within TRIGA ACPR facility, installed at INSTITUTE for NUCLEAR POWER REACTORS, Pitesti, ROMANIA. Studies of the safety issues took a great international developement during last years. In USA, Japan, owners of the similar reactors, and USSR there are a big commitment to such programs, intended to establish the nuclear fuel behaviour under RIA-conditions. In our country, too, there are programs aiming a complete testing of the CANDU type fuels. As it is known, RIA is not a CANDU specific accident, but the fuel behaviour in such conditions can give useful informations on the fuel cladding failure threshold and about reflooding post LOCA heat transfer condition. Based on some papers and specific requirements it was initiated and developed a safety research program on CANDU type fuel using the ACPR. The paper describes the reactor,test capsule, instrumentation, fuel samples, tests, post irradiation results. (orig.)

  20. Co-localisation studies of Arabidopsis SR splicing factors reveal different types of speckles in plant cell nuclei

    SR proteins are multidomain splicing factors which are important for spliceosome assembly and for regulation of alternative splicing. In mammalian nuclei these proteins localise to speckles from where they are recruited to transcription sites. By using fluorescent protein fusion technology and different experimental approaches it has been shown that Arabidopsis SR proteins, in addition to diffuse nucleoplasmic staining, localise into an irregular nucleoplasmic network resembling speckles in mammalian cells. As Arabidopsis SR proteins fall into seven conserved sub-families we investigated co-localisation of members of the different sub-families in transiently transformed tobacco protoplast. Here we demonstrate the new finding that members of different SR protein sub-families localise into distinct populations of nuclear speckles with no, partial or complete co-localisation. This is particularly interesting as we also show that these proteins do interact in a yeast two-hybrid assay as well as in pull-down and in co-immunopreciptiation assays. Our data raise the interesting possibility that SR proteins are partitioned into distinct populations of nuclear speckles to allow a more specific recruitment to the transcription/pre-mRNA processing sites of particular genes depending on cell type and developmental stage

  1. 50 CFR 23.52 - What are the requirements for replacing a lost, damaged, stolen, or accidentally destroyed CITES...

    2010-10-01

    ... lost, damaged, stolen, or accidentally destroyed CITES document? 23.52 Section 23.52 Wildlife and...) CONVENTION ON INTERNATIONAL TRADE IN ENDANGERED SPECIES OF WILD FAUNA AND FLORA (CITES) Application..., or accidentally destroyed CITES document? (a) Purpose. A Management Authority may issue a...

  2. Swift heavy ion irradiation effects in α poly(vinylidene fluoride)

    The goal of this study is to characteristic and to localised defects created in α Poly (vinylidene fluoride) after swift heavy ion irradiations. PVDF films are irradiated with several Swift Heavy Ions (SHI), in the electronic stopping power (dE/dx)e, in order to study the influence of irradiation parameters (absorbed dose, ion)). These irradiated films are studied by different analysis techniques such as FTIR, ESR (X and Q band) spectroscopies and DSC. The crystalline level of PVDF is about 50% and we follow it destruction and amorphization as the absorbed dose increase by DSC and FTIR studies. The variation of the various FTIR bands allow us to observe the unsaturations induced by SHI radiations. Two sets of defects are observed: those which yield is sensitive to an increase of (dE/dx)e and those that are not. A spatial distribution of the various defects within the talent track is provided and defects that are difficult to create are the closest of the ion path. The different kind of radicals created after irradiations are studied by ESR spectroscopy. Alkyl, peroxy and polyenyl radicals are detected after SHI radiations like after electron or γ irradiations. Their yield of creation is independent of (dE/dx)e and their localised in the crystalline zone or/and at the interfacial zone between crystalline and amorphous one. An other kind of radicals is created only after SHI radiations that are specific of the SHI-polymer interaction. We observe that these radicals are localised on a carbon cluster, in the core of the latent track for low doses and highly sensitive at the (dE/dx)e of the ion. (author)

  3. Medical Inspection and Regrading of Workers Accidentally Exposed to Radiation

    Medical inspection and regrading of workers exposed to radiation at the time of an accident are basically variable according to the seriousness of the exposure. Minor cases only need a check-up at relatively lengthy intervals and regrading does not usually present any great problem. This paper deals with the particular case of whole-body irradiation involving very high exposure of a lower limb. Problems of medical supervision and regrading are still arising three years after the accident, without it being possible to determine or even foresee a consolidation period. The issues involved are legal, medical, social and psychological, and also relate to efficiency. The legal aspect of an accident of this kind involves a series of obligations, such as the prolonged inspection laid down in legal instruments, which varies, moreover, with the country. It also includes the jurisprudential aspect, in particular the much-debated distinction between an industrial accident and an occupational disease. The medical aspect of long-term supervision entails a fairly frequent check on the proper functioning of the different systems, with particular stress on blood sampling and genetic tests, including a chromosome examination. The social aspect is particularly important in the event of nuclear accidents. In the case under consideration the accident resulted in total incapacity to work for almost three years, followed by resumption of work on a part-time basis. The long period of isolation of the patient and the anxiety of his family and those around him regarding the possible outcome of the accident are aspects peculiar to serious exposure to radiation. The psychological aspect is furthermore a part of the social aspect. During his period of confinement the patient only comes into contact with a few persons, whereas once he has been discharged from hospital he is an object of curiosity and publicity that are at times excessive. Finally, regrading that does not involve downgrading

  4. Accidental ingestion of Ecstasy by a toddler: unusual cause for convulsion in a febrile child.

    Cooper, A J; Egleston, C V

    1997-05-01

    The case is reported of a toddler who presented with an apparent febrile convulsion. The final diagnosis was that of accidental ingestion of Ecstasy. The child made an uneventful recovery. Ecstasy toxicity should be added to the list of differential diagnoses in a child presenting with fever and an unexplained seizure. PMID:9193992

  5. Accidental ingestion of Ecstasy by a toddler: unusual cause for convulsion in a febrile child.

    Cooper, A. J.; Egleston, C. V.

    1997-01-01

    The case is reported of a toddler who presented with an apparent febrile convulsion. The final diagnosis was that of accidental ingestion of Ecstasy. The child made an uneventful recovery. Ecstasy toxicity should be added to the list of differential diagnoses in a child presenting with fever and an unexplained seizure.

  6. Consequences of a double-ended severance of a steam generator tube and accidental development scenario

    The results of theoretical analysis for accidental sequences in a modular steam generator are presented. The most probable water leak development in sodium in case of steam generator emergency stop faults is examined. In all schemes the reactor safety is preserved

  7. Accidental displacement of a dental implant into the submandibular space during explantation.

    Kim, B H; Kim, B C; Lee, J

    2016-07-01

    Dental implants are reliable and widely used, but complications such as peri-implantitis occasionally necessitate their removal. Accidents during removal are similar to those that may occur during extraction, including displacement into another structure in the maxillofacial region. We present a rare case of accidental displacement into the submandibular space, which happened during an attempt to remove an implant. PMID:26507676

  8. Guidebook for the treatment of accidental internal radionuclide contamination of workers

    This work is a guide intended for the treatment of accidental internal radionuclide contamination of workers. It is a practical guide, based on an actual treatments examination to eliminate the incorporated radionuclides from organism, and to avoid the radioinduced diseases development. It should be used by work doctors, emergency doctors, radiation protection agents, nurses and medical personnel. (N.C.)

  9. Changes in Surface Charge Density of Blood Cells in Fatal Accidental Hypothermia.

    Szeremeta, Michał; Petelska, Aneta Dorota; Kotyńska, Joanna; Pepiński, Witold; Naumowicz, Monika; Figaszewski, Zbigniew Artur; Niemcunowicz-Janica, Anna

    2015-12-01

    The objective of this research was to evaluate postmortem changes concerning electric charge of human erythrocytes and thrombocytes in fatal accidental hypothermia. The surface charge density values were determined on the basis of the electrophoretic mobility measurements of the cells conducted at various pH values of electrolyte solution. The surface charge of erythrocyte membranes after fatal accidental hypothermia increased compared to the control group within whole range of experimental pH values. Moreover, a slight shift of the isoelectric point of erythrocyte membranes towards high pH values was observed. The surface charge of thrombocyte membranes in fatal accidental hypothermia decreased at low pH compared to the control group. However, at pH range 4-9, the values increased compared to the control group. The isoelectric point of thrombocyte membranes after fatal accidental hypothermia was slightly shifted towards low pH values compared to the control group. The observed changes are probably connected with the partial destruction and functional changes of the blood cell structure. PMID:26364031

  10. TRACE-RELAP comparison in simulation of accidental situations stop conditions under different plant configurations

    RHRS (Residual heat removal system) loss in accidental conditions would be a non-negligible risk to the safety of the plant, especially if it is in certain configurations that make it more vulnerable by undermining its core cooling capability. One occurs when the primary is in terms of reduced inventory or half loop.

  11. El recuerdo de los accidentes de tráfico: Memoria de los testigos

    Diges Junco, Margarita; Antonio L. Manzanero

    1995-01-01

    En este trabajo se trata la recogida de datos subjetivos originados por las personas presentes en el accidente, una cuestión de vital importancia en la investigación de éstos y cuya exactitud depende de dos factores principales: la honestidad y la memoria de la persona que los proporciona.

  12. International conference and workshop on modeling and mitigating the consequences of accidental releases of hazardous materials

    This conference was held September 26--29, 1995 in New Orleans, Louisiana. The purpose of this conference was to provide a multidisciplinary forum for exchange of state-of-the-art information on the consequences of accidental releases of hazardous materials. Attention is focused on air dispersion of vapors. Individual papers have been processed separately for inclusion in the appropriate data bases

  13. Accidental hypothermia: Rewarming treatments, complications and outcomes from one university medical centre

    G.J. van der Ploeg; J.C. Goslings; B.H. Walpoth; J.J.L.M. Bierens

    2010-01-01

    Aim of the study: Accidental hypothermia (AH) is a complex and life threatening condition. Knowledge about epidemiology, rewarming treatments, complications and outcome is limited. This study was initiated to obtain data on causes, rewarming treatments and complications. Methods: A retrospective coh

  14. [Risk of acute hepatic insufficiency in children due to chronic accidental overdose of paracetamol (acetaminophen)

    Hameleers-Snijders, P.; Hogeveen, M.; Smeitink, J.A.M.; Kramers, C.; Draaisma, J.M.T.

    2007-01-01

    Two girls aged 4 and 3 years, respectively, experienced acute liver failure due to accidental ingestion of supratherapeutic doses of paracetamol (90 mg/kg/day or more). Recognition of chronic paracetamol intoxication as a cause of acute hepatic failure is often delayed. It is important to consider t

  15. SUMMARY OF ACCIDENTAL RELEASES OF RADIOACTIVITY DETECTED OFF THE NEVADA TEST SITE, 1963-1986

    Of the more than 450 underground nuclear explosives tests conducted at the Nevada Test Site from August 1963 (signing of the Limited Test Ban Treaty) through the end of 1986, only 23 accidentally released radioactivity that was detectable beyond the boundary of the NTS. Of these ...

  16. Intraperitoneal granulomatous foreign body reaction after accidental perforation of the abdominal wall. Case report

    Lanng, C; Winther-Nielsen, H; Hougen, H P

    After an accidental perforation by a wooden stake of the abdominal wall and distal ileum a 28-year-old man developed an aggressive granulomatous foreign body reaction of the greater omentum with high fever and abdominal pain. The patient was cured by omental resection and prednisone treatment....

  17. The accidental city : violence, economy and humanitarianism in Kakuma refugee camp Kenya

    Jansen, B.J.

    2011-01-01

    In this research I examine social ordering processes in Kakuma refugee camp in Kenya. I view the camp as an accidental city, by which I challenge the image of the camp as a temporary and artificial waiting space or a protracted refugee crisis per se. The reference to the city is both metaphorical

  18. Multiple scattering and accidental coincidences in the J-PET detector simulated using GATE package

    Kowalski, P; Wiślicki, W; Raczyński, L; Bednarski, T; Białas, P; Bułka, J; Czerwiński, E; Gajos, A; Gruntowski, A; Kamińska, D; Kapłon, Ł; Kochanowski, A; Korcyl, G; Kowal, J; Kozik, T; Krzemień, W; Kubicz, E; Niedźwiecki, Sz; Pałka, M; Rudy, Z; Salabura, P; Sharma, N G; Silarski, M; Słomski, A; Smyrski, J; Strzelecki, A; Wieczorek, A; Wochlik, I; Zieliński, M; Zoń, N

    2015-01-01

    Novel Positron Emission Tomography system, based on plastic scintillators, is developed by the J-PET collaboration. In order to optimize geometrical configuration of built device, advanced computer simulations are performed. Detailed study is presented of background given by accidental coincidences and multiple scattering of gamma quanta.

  19. PREVENTION REFERENCE MANUAL: CHEMICAL SPECIFIC, VOLUME 14: CONTROL OF ACCIDENTAL RELEASES OF PHOSGENE

    The report, discussing phosgene, is one of a series addressing the prevention of accidental releases of toxic chemicals. Phosgene, a highly reactive and corrosive liquid that boils at room temperature has an Immediately Dangerous to Life and Health (lDLH) conctntration of 2 ppm, ...

  20. Paris: a software for simulation of post-accidental radioecological situations

    Paris, a software for simulation of post-accidental radioecological situations. The Paris software (Post-Accidental Radiological Imitation System) has for function to generate post-accidental situation, by simulating the different data flows, notably measurements results, such as they could reach the experts in a real-life situation. Situations proposed are particularly realistic because established by analogy with situations observed after the Chernobyl accident. Many functions reveal this realism: the taking into account of measurements capacity, population movements, the consideration of countermeasures capacity of application and their real efficiency... The data bases used are very extensive which allows diversity of information that the experts will have to process in such a situation. The Paris software constitutes a computerized functional synthesis of operational lessons that one can draw from the Chernobyl accident. In this sense, it presents a considerable interest for preparing experts in the management of post-accidental situations. During crisis exercises, data generated by Paris can be considered as a virtual reality. Experts can compare results from calculation tools like ASTRAL, with this virtual reality. (authors)

  1. Ecosystem Service Potentials, Flows and Demands – Concepts for Spatial Localisation, Indication and Quantification

    Benjamin Burkhard

    2014-06-01

    Full Text Available The high variety of ecosystem service categorisation systems, assessment frameworks, indicators, quantification methods and spatial localisation approaches allows scientists and decision makers to harness experience, data, methods and tools. On the other hand, this variety of concepts and disagreements among scientists hamper an integration of ecosystem services into contemporary environmental management and decision making. In this article, the current state of the art of ecosystem service science regarding spatial localisation, indication and quantification of multiple ecosystem service supply and demand is reviewed and discussed. Concepts and tables for regulating, provisioning and cultural ecosystem service definitions, distinguishing between ecosystem service potential supply (stocks, flows (real supply and demands as well as related indicators for quantification are provided. Furthermore, spatial concepts of service providing units, benefitting areas, spatial relations, rivalry, spatial and temporal scales are elaborated. Finally, matrices linking CORINE land cover types to ecosystem service potentials, flows, demands and budget estimates are provided. The matrices show that ecosystem service potentials of landscapes differ from flows, especially for provisioning ecosystem services.

  2. Chemical shift imaging and localised magnetic resonance spectroscopy in full-term asphyxiated neonates

    Diagnosis of brain lesions after birth anoxia-ischemia is essential for appropriate management. Clinical evaluation is not sufficient. MRI has been proven to provide useful information. To compare abnormalities observed with MRI, including diffusion-weighted imaging (DWI), localised magnetic resonance spectroscopy (MRS) and chemical shift imaging (CSI) and correlate these findings with the clinical outcome. Fourteen full-term neonates with birth asphyxia were studied. MRI, MRS and CSI were performed within the first 4 days of life. Lesions observed with DWI were correlated with outcome, but the apparent diffusion coefficient (ADC) did improve diagnostic confidence. The mean value of Lac/Cr for the neonates with a favourable outcome was statically lower than for those who died (0.22 vs 1.04; P = 0.01). The same results were observed for the Lac/NAA ratio (0.21 vs 1.23; P = 0.01). Data obtained with localised MRS and CSI were correlated for the ratio N-acetyl-aspartate/choline, but not for the other metabolites. No correlation was found between the ADC values and the metabolite ratios. Combination of these techniques could be helpful in our understanding of the physiopathological events occurring in neonates with asphyxia. (orig.)

  3. Subcritical monitoring studies in BZD/2 using alternative absorber compositions and a localised neutron source

    A series of supplementary subcritical monitoring studies has been carried out in the Single Annular Core BZD/2. The first part concerned the use of alternative absorber compositions: 40 % enriched B4C and Eu2O3. The worth of the 40 % enriched B4C absorber relative to the naturally enriched one was found to be significantly lower than for the corresponding measurements in the conventional core BZB (1.197 versus 1.259). Although an influence of the harder spectrum in BZD is likely, the results of similar studies in BZC seem to contradict this assumption. Within the experimental errors, the worth of the Eu2O3 absorber relative to natural B4C agrees with that found in BZB. As in previous investigations, diffusion theory calculations were found to overestimate the worth of the 40 % enriched B4C absorber relative to the natural one by several percent. The worth of Eu2O3 relative to B4C-nat was again severely underpredicted. In a second series of experiments, a localised neutron source (Cf-252) was introduced into the core. For the two absorber arrays established in the presence of the source, the MSM analysis produced reactivities, which agree within about 0.5 % relative with those, obtained from previous measurements of these arrays without the localised source. This confirms the satisfactory performance of the MSM technique even in a strongly decoupled annular system with very irregular source distribution

  4. Organisation as a key factor in Localised Agri-Food Systems (LAFS

    Corrado Giacomini

    2015-05-01

    Full Text Available Most studies of Localised Agri-Food Systems (LAFS focus on the localised concentration of members and firms, and pay less attention to organisational factors, particularly those of an exogenous nature. This paper focuses on the role of organisation in a LAFS, assessing the efficacy of EU organisational measures aimed at strengthening the concentration of supply from the recent CAP reform 2014-2020. The paper has three sections. Part One describes the evolution of the concept of LAFS. Part Two examines the leading role played by institutions in organising relationships between firms in a LAFS. The example provided is that of the measures affecting the organisation of supply introduced by the recent CAP reform, 2014-2020. It makes particular reference to the Distretto del pomodoro da industria – Nord Italia (‘Industrial Tomato District – Northern Italy’. Part Three describes how organisational factors can lead to the creation of a LAFS, while the criterion of proximity is necessary but not sufficient.

  5. Functional MRI of the brain: localisation of eloquent cortex in focal brain lesion therapy

    Dymarkowski, S.; Sunaert, S.; Oostende, S. van; Hecke, P. van; Wilms, G.; Demaerel, P.; Marchal, G. [Department of Radiology, University Hospitals, Leuven (Belgium); Nuttin, B.; Plets, C. [Department of Neurosurgery, University Hospitals, Leuven (Belgium)

    1998-12-01

    The aim of this study was to assess the feasibility of functional MRI (fMRI) in a clinical environment on a large patient group, and to evaluate the pretherapeutic value of localisation of eloquent cortex. Forty patients with focal brain lesions of different origin were studied using fMRI. Functional information was obtained using motor, somatosensory, auditory and phonological stimuli depending on the localisation of the lesions. To obtain information about the spatial accuracy of fMRI, the results were compared with postoperative electrocortical stimulation. Two patients with secondary trigeminal neuralgia were scanned using a motor protocol and were implanted with an extradural plate electrode. Imaging was successful in 40 of 42 patients (including the 2 with trigeminal neuralgia). These patients were analysed for strength of activation, the relation of the lesion to activation sites and the presence of mass effect. The correlation between these data and surgical findings provided significant additional clinical information. Functional MRI can be accurately performed in patients with focal brain lesions using a dedicated approach. Functional MRI offers important clinical information as a contribution to a decrease in posttherapeutic morbidity. The accuracy of the technique can be confirmed by other modalities, including invasive cortical electrostimulation. (orig.) With 7 figs., 2 tabs., 25 refs.

  6. Detection and cellular localisation of the synthetic soluble macromolecular drug carrier pHPMA

    Synthetic macromolecules such as copolymers of N-(2-hydroxypropyl)methacrylamide (pHPMA) are potential carriers for the delivery of drugs owing to their ability to passively accumulate in solid tumours [enhanced permeation and retention (EPR) effect]. To gain further knowledge about the biodistribution and the cellular localisation, poly(HPMA) was prepared for labelling by introducing biotin molecules. Biotinylated pHPMA (5 mol%) was intravenously injected into tumour-bearing rats and the accumulation of biotin-pHPMA was visualised using a streptavidin-alkaline phosphatase technique at day 7 post injection. In spite of the high solubility of pHPMA copolymers and the lack of attachment to cell structures, the biotinylated polymer could be easily detected in tissues fixed in 10% paraformaldehyde-phosphate buffer at 4 C for 48 h. While biotin-pHPMA could be detected intracytoplasmically in liver and spleen, a predominantly interstitial localisation was observed within the anaplastic prostate carcinoma (Dunning R3327-AT1). How biotin as a label influences the biodistribution of poly(HPMA) was assessed by scintigraphy, autoradiography and histology comparing homopolymer poly(HPMA) with biotin-pHPMA. The organ distribution patterns of the two polymers correlated well, except with respect to kidney. It is assumed that the accumulation of biotin-pHPMA in the distal tubuli is due to a biotin transporter in the brush border membrane. The technique presented is useful for a more comprehensive understanding of the biodistribution of soluble macromolecules. (orig.)

  7. Treatment of localised prostate cancer with transrectal high intensity focused ultrasound.

    Chapelon, J Y; Ribault, M; Vernier, F; Souchon, R; Gelet, A

    1999-03-01

    With the advent of PSA dosing, an increasing number of prostate cancers are being detected at a local stage. Since 1989, our group has been developing a research project with the aim of establishing treatment of localised prostate cancer by means of HIFU. The treatment is performed transrectally, using ultrasound imaging guidance only. The quality of HIFU treatment depends on four factors: the intensity of the transmitted pulse, the exposure time, the signal frequency, and the time between two firing bursts. The lesions are created by a thermal effect. Their slightly conical form is due to the absorption of ultrasound by tissue, enhanced by cavitation bubbles. Results obtained since 1993 demonstrate that transrectally administered HIFU treatment achieves local control of localised prostate cancer in 80% of cases, with 70% complete success and 30% partial response. The use of an annular array probe with variable focus and frequency should significantly improve results in the future. Finally, real time visual display of the damaged tissue via differential imaging of the attenuation coefficient should give the surgeon an instant appreciation of the result of the sequence. It would thus be possible to repeat treatment of insufficiently covered zones in the same session. PMID:10099164

  8. Rare events statistics of random walks on networks: localisation and other dynamical phase transitions

    De Bacco, Caterina; Guggiola, Alberto; Kühn, Reimer; Paga, Pierre

    2016-05-01

    Rare event statistics for random walks on complex networks are investigated using the large deviation formalism. Within this formalism, rare events are realised as typical events in a suitably deformed path-ensemble, and their statistics can be studied in terms of spectral properties of a deformed Markov transition matrix. We observe two different types of phase transition in such systems: (i) rare events which are singled out for sufficiently large values of the deformation parameter may correspond to localised modes of the deformed transition matrix; (ii) ‘mode-switching transitions’ may occur as the deformation parameter is varied. Details depend on the nature of the observable for which the rare event statistics is studied, as well as on the underlying graph ensemble. In the present paper we report results on rare events statistics for path averages of random walks in Erdős–Rényi and scale free networks. Large deviation rate functions and localisation properties are studied numerically. For observables of the type considered here, we also derive an analytical approximation for the Legendre transform of the large deviation rate function, which is valid in the large connectivity limit. It is found to agree well with simulations.

  9. Functional MRI of the brain: localisation of eloquent cortex in focal brain lesion therapy

    The aim of this study was to assess the feasibility of functional MRI (fMRI) in a clinical environment on a large patient group, and to evaluate the pretherapeutic value of localisation of eloquent cortex. Forty patients with focal brain lesions of different origin were studied using fMRI. Functional information was obtained using motor, somatosensory, auditory and phonological stimuli depending on the localisation of the lesions. To obtain information about the spatial accuracy of fMRI, the results were compared with postoperative electrocortical stimulation. Two patients with secondary trigeminal neuralgia were scanned using a motor protocol and were implanted with an extradural plate electrode. Imaging was successful in 40 of 42 patients (including the 2 with trigeminal neuralgia). These patients were analysed for strength of activation, the relation of the lesion to activation sites and the presence of mass effect. The correlation between these data and surgical findings provided significant additional clinical information. Functional MRI can be accurately performed in patients with focal brain lesions using a dedicated approach. Functional MRI offers important clinical information as a contribution to a decrease in posttherapeutic morbidity. The accuracy of the technique can be confirmed by other modalities, including invasive cortical electrostimulation. (orig.)

  10. Axial super-localisation using rotating point spread functions shaped by polarisation-dependent phase modulation.

    Roider, Clemens; Jesacher, Alexander; Bernet, Stefan; Ritsch-Marte, Monika

    2014-02-24

    We present an approach for point spread function (PSF) engineering that allows one to shape the optical wavefront independently in both polarisation directions, with two adjacent phase masks displayed on a single liquid-crystal spatial light modulator (LC-SLM). The set-up employs a polarising beam splitter and a geometric image rotator to rectify and process both polarisation directions detected by the camera. We shape a single-lobe ("corkscrew") PSF that rotates upon defocus for each polarisation channel and combine the two polarisation channels with a relative 180° phase-shift on the computer, merging them into a single PSF that exhibits two lobes whose orientation contains information about the axial position. A major advantage lies in the possibility to measure and eliminate the aberrations in the two polarisation channels independently. We demonstrate axial super-localisation of isotropically emitting fluorescent nanoparticles. Our implementation of the single-lobe PSFs follows the method proposed by Prasad [Opt. Lett.38, 585 (2013)], and thus is to the best of our knowledge the first experimental realisation of this suggestion. For comparison we also study an approach with a rotating double-helix PSFs (in only one polarisation channel) and ascertain the trade-off between localisation precision and axial working range. PMID:24663724

  11. Low-frequency variability in idealised GCM experiments with circumpolar and localised storm tracks

    W. Müller

    2002-01-01

    Full Text Available Idealised global circulation model simulations with circumpolar and localised (one and two storm tracks are re-analysed to determine scaling, intermittency and phase-space structures. In a hundred year experiment with a circumpolar storm track, the spectrum S(f of the first principal component of the zonal wind fluctuations shows the following power law regimes: (a a short-term memory between f- -4 and f  -2 up to 50 days and (b a long-term memory f -1 from 50 to 400 days and f -0.24 beyond 400 days, similar to observed maritime single station near-surface air temperature data. In the presence of localised storm tracks, the wave number two dominates the dynamics and a long-term memory cannot be detected. The recurrence plot is introduced as a novel tool to comprehensively visualise the evolution of the dynamical system in terms of state separations (distances in phase space. The patterns allow for a qualitative interpretation of the underlying local phenomena in phase space, such as waves, analogs, extremes, and global regimes. Attractor dimensions are, in general, larger than 10, but they appear to be lower in the wave-dominated regimes of the double storm track experiment.

  12. Food irradiation

    The colloquium has been held on the occasion of the commissioning of a new linear electron accelerator. The 17 papers presented by the experts give a survey of the present status of food irradiation and related aspects. Every paper has been analysed and prepared for retrieval from the database. (orig.)

  13. Accidental behaviour of nuclear fuel in a warehousing site under air: investigation of the nuclear ceramic oxidation and of fission gas release; Comportement accidentel du combustible nucleaire dans un site d'entreposage sous air: Etude de l'oxydation de la ceramique nucleaire et du relachement des gaz de fission

    Desgranges, L.

    2006-12-15

    After a brief presentation of the context of his works, i.e. the nuclear fuel, its behaviour in a nuclear reactor, and studies performed in high activity laboratory, the author more precisely presents its research topic: the behaviour of defective nuclear fuel in air. Then, he describes the researches performed in three main directions: firstly, the characterization and understanding of fission gas localisation (experimental localisation, understanding of the bubble forming mechanisms), secondly, the determination of mechanisms related to oxidation (atomic mechanisms related to UO{sub 2} oxidation, oxidation of fragments of irradiated fuel, the CROCODILE installation). He finally presents his scientific project which notably deals with fission gas release (from UO{sub 2} to U{sub 3}O{sub 7}, and from U{sub 3}O{sub 7} to U{sub 3}O{sub 8}), and with further high activity laboratory experiments

  14. Improving the performance of monocular visual simultaneous localisation and mapping through the use of a gimballed camera

    Playle, Nicholas

    In this thesis modern vision based localisation methods are discussed and contrasted with existing satellite based approaches. Shortcomings are noted and potential solutions are highlighted. A novel method of using a gimballed camera to perform visual Simultaneous Localisation and Mapping (SLAM) is proposed, along with a control algorithm to point the camera toward feature dense regions. This method is then modularly coupled with existing visual SLAM techniques allowing seamless integration across different platforms. Ground tests are performed to verify operation of the gimbal controller and rotation inverser. Results from experimental flight tests are incorporated as a final means of obtaining information to verify gimbal operation.

  15. Intérêt du guidage 3D et de la localisation des biopsies de prostate par voie endorectale

    Mozer, Pierre; Chevreau, Grégoire; Troccaz, Jocelyne; Renard-Penna, Raphaëlle

    2011-01-01

    International audience La réalisation de biopsies de prostate, le plus souvent par voie endorectale, est primordiale pour le diagnostic et l'évaluation du pronostic du cancer. La précision de la localisation des biopsies est sujette à caution. Le développement de systèmes informatiques permet d'enregistrer avec précision leur localisation et de les guider pour améliorer leur distribution. Ces mêmes dispositifs permettent de fusionner images échographiques et images IRM et de fusionner diff...

  16. Organization of crop and animal production in dairy farms localised in three chosen regions of lubelskie voivodeship

    Jolanta Bojarszczuk

    2010-01-01

    Full Text Available The evaluation of organization of crop and animal production in dairy farms localised in three regions in Lubelskie voivodeship was presented in the paper. The data source was questionnaire research. The study was trained in 145 farms. The provided analysis showed that cereals had significantly share in pattern system in tested farms. Researched farms are differentiated of occupied differentiation of cropping pattern and density livestock between farms localised in different regions of Lubelskie voivodeship caused different level of intensity of organization animal and crops production. The differentiation of indicators was especially significant between farms in Krasnystaw and Ryki.

  17. Basolateral localisation of KCNQ1 potassium channels in MDCK cells: molecular identification of an N-terminal targeting motif

    Jespersen, Thomas; Rasmussen, Hanne B; Grunnet, Morten; Jensen, Henrik S.; Angelo, Kamilla; Dupuis, Delphine S; Vogel, Lotte K; Jorgensen, Nanna K; Klaerke, Dan A; Olesen, Søren-Peter

    channels are located basolaterally when expressed in polarised MDCK cells. The basolateral localisation of KCNQ1 is not affected by co-expression of any of the five KCNE beta-subunits. We characterise two independent basolateral sorting signals present in the N-terminal tail of KCNQ1. Mutation of the...... tyrosine residue at position 51 resulted in a non-polarized steady-state distribution of the channel. The importance of tyrosine 51 in basolateral localisation was emphasized by the fact that a short peptide comprising this tyrosine was able to redirect the p75 neurotrophin receptor, an otherwise apically...

  18. Food irradiation: An update

    Recent regulatory and commercial activity regarding food irradiation is highlighted. The effects of irradiation, used to kill insects and microorganisms which cause food spoilage, are discussed. Special attention is given to the current regulatory status of food irradiation in the USA; proposed FDA regulation regarding the use of irradiation; pending irradiation legislation in the US Congress; and industrial applications of irradiation

  19. Food irradiation

    Various aspects of food treatment by cobalt 60 or caesium 137 gamma radiation are reviewed. One of the main applications of irradiation on foodstuffs lies in its ability to kill micro-organisms, lethal doses being all the lower as the organism concerned is more complex. The effect on parasites is also spectacular. Doses of 200 to 300 krad are recommended to destroy all parasites with no survival period and no resistance phenomenon has ever been observed. The action of gamma radiation on macromolecules was also investigated, the bactericide treatment giving rise to side effects by transformation of food components. Three examples were studied: starch, nucleic acids and a whole food, the egg. The organoleptic aspect of irradiation was examined for different treated foods, then the physical transformations of unpasteurized, heat-pasteurized and radio-pasteurized eggs were compared. The report ends with a brief analysis of the toxicity and conditions of application of the treatment

  20. Food irradiation

    Radiation processing of food is based on irradiation by gamma radiation from a 60Co source or X-ray with energy < 5 MeV or electron beam with energy < 10 MeV. This technique is now completely mastered. About 30 countries use this technique to extend the storage life of food but the total quantity processed is weak, only 30000 tons a year for France. Some countries like Morocco or Tunisia have launched technical programmes about the radiation processing of dates and vegetable oil. These programmes may lead to the creation of a quality label. A joint laboratory between CEA and the Aix-Marseille-3 university is working on the detection of food irradiation in order to fight the fraud. 3 techniques are being investigated: thermoluminescence, electronic paramagnetism resonance and a chemical method. (A.C.)

  1. Endolymphatic irradiation

    The authors analysed the clinical evolution and the result of renal transplantation some years after irradiation in 24 patients (group I) who received endolymphatic 131I as a pre-transplantation immunesuppresive measure. The control group (group II) consisted of 24 non-irradiated patients comparable to group I in age, sex, primary disease, type of donor and immunesuppressive therapy. Significant differences were observed between the two groups regarding such factors a incidence and reversibility of rejection crises in the first 60 post-transplantation days, loss of kidney due to rejection, and dosage of azathioprine. The authors conclude that this method, besides being harmless, has prolonged immunesuppressive action, its administration being advised for receptores of cadaver kidneys, mainly those who show positive cross-match against HLA antigens for painel. (Author)

  2. Study of the possibility of localising a channel instability in Forsmark-1

    A special type of instability occurred in the Swedish BWR Forsmark 1 in 1996. In contrast to the better known global or regional instabilities, the decay ratio appeared to be very high in one half of the core and quite low in the other half. A more detailed analysis showed that the most likely reason for the observed behaviour is a local perturbation of thermohydraulic character induced by the incorrect positioning of a fuel assembly. In such a case it is of importance to determine the position of the unseated assembly already during operation so that it can be easily found during reloading. The subject of this paper is to report on development and application of a method by which the position of such a local perturbation can be determined. The method can be separated into two parts that support and complement each other. First a visualisation technique was elaborated which displays the space-time behaviour of the neutron flux oscillations in the core. This visualisation expedites a very good qualitative comprehension of the situation and can be useful for the operators. It also gives a basis for the application of the localisation algorithm. Second, a quantitative localisation method, based on reactor physical models of the perturbation and of the transfer function between the perturbation and the flux oscillations, was elaborated. This latter takes noise spectra from selected detectors as input and yields the perturbation position as output. The strength of the method lies in its potentially high spatial resolution, which is smaller than the typical distance between two adjacent LPRM detectors. The method was tested on simulated data, and then applied to the Forsmark measurements. The location of the disturbance, found by the algorithm, is in accordance with independent judgements for the case, and close to a position where an unseated assembly was found during refuelling. The purpose of this study was to develop and test the localisation method. To apply the

  3. Gliadin peptide P31-43 localises to endocytic vesicles and interferes with their maturation.

    Maria Vittoria Barone

    Full Text Available BACKGROUND: Celiac Disease (CD is both a frequent disease (1:100 and an interesting model of a disease induced by food. It consists in an immunogenic reaction to wheat gluten and glutenins that has been found to arise in a specific genetic background; however, this reaction is still only partially understood. Activation of innate immunity by gliadin peptides is an important component of the early events of the disease. In particular the so-called "toxic" A-gliadin peptide P31-43 induces several pleiotropic effects including Epidermal Growth Factor Receptor (EGFR-dependent actin remodelling and proliferation in cultured cell lines and in enterocytes from CD patients. These effects are mediated by delayed EGFR degradation and prolonged EGFR activation in endocytic vesicles. In the present study we investigated the effects of gliadin peptides on the trafficking and maturation of endocytic vesicles. METHODS/PRINCIPAL FINDINGS: Both P31-43 and the control P57-68 peptide labelled with fluorochromes were found to enter CaCo-2 cells and interact with the endocytic compartment in pulse and chase, time-lapse, experiments. P31-43 was localised to vesicles carrying early endocytic markers at time points when P57-68-carrying vesicles mature into late endosomes. In time-lapse experiments the trafficking of P31-43-labelled vesicles was delayed, regardless of the cargo they were carrying. Furthermore in celiac enterocytes, from cultured duodenal biopsies, P31-43 trafficking is delayed in early endocytic vesicles. A sequence similarity search revealed that P31-43 is strikingly similar to Hrs, a key molecule regulating endocytic maturation. A-gliadin peptide P31-43 interfered with Hrs correct localisation to early endosomes as revealed by western blot and immunofluorescence microscopy. CONCLUSIONS: P31-43 and P57-68 enter cells by endocytosis. Only P31-43 localises at the endocytic membranes and delays vesicle trafficking by interfering with Hrs

  4. Adverse events in humans associated with accidental exposure to the livestock brucellosis vaccine RB51.

    Ashford, David A; di Pietra, Jennifer; Lingappa, Jairam; Woods, Christopher; Noll, Heather; Neville, Bridget; Weyant, Robbin; Bragg, Sandra L; Spiegel, Richard A; Tappero, Jordan; Perkins, Bradley A

    2004-09-01

    Brucella abortus strain RB51 vaccine, is an attenuated live bacterial vaccine that was licensed conditionally by the Center for Veterinary Biologics, Veterinary Services, Animal and Plant Health Inspection Service, USDA, on 23 February 1996, for vaccination of cattle in the United States. Accidental human inoculations can occur during vaccination of cattle, and previous live Brucella vaccines designed for cattle have been known to cause brucellosis in humans. The Centers for Disease Control and Prevention (CDC) established passive surveillance for accidental inoculation with the RB51 vaccine in the United States to determine if this veterinary vaccine is associated with human disease, to describe the circumstances of accidental inoculation, to evaluate the potential efficacy of post-exposure chemoprophylaxis, and to develop recommendations for post-exposure management following exposure to RB51. Reports were received from 26 individuals. Accidental exposure to RB51 occurred by needle stick injury in 21 people (81%), conjunctival spray exposure in four (15%), and spray exposure of an open wound in one (4%) individual. At least one systemic symptom was reported in 19 (73%) people, including three (12%) who reported persistent local reactions with systemic involvement. One case required surgery, and B. abortus strain RB51 was isolated from the wound of that individual. Seven cases reported no adverse event associated with accidental exposure. Nine cases reported previous exposure to Brucella vaccines, including one case who also reported a previous diagnosis of brucellosis following exposure to S19 vaccine. Accidental needle stick injuries and conjunctival or open wound exposures of humans with the RB51 vaccine are associated with both local and systemic adverse events in the United States that are consistent with brucellosis; however, it remains undetermined if strain RB51 vaccine can cause systemic brucellosis in humans. Early culture attempts on those exposed and

  5. Modelling of accidental released toxic gases for emergency responders in Austria, Kosovo and Bulgaria.

    Stenzel, Sirma; Baumann-Stanzer, Kathrin; Gashi, Salih; Thaci, Bashkim; Batchvarova, Ekaterina; Spassova, Tatiana

    2010-05-01

    In the case of accidental release of hazardous gases in the atmosphere, the emergency responders need a reliable and fast tool to assess the possible consequences and apply the optimal countermeasures. A number of models for the prediction and simulation of hazard areas affected by accidental releases of toxic gases are available worldwide. Modelling accidental releases may be required for a variety of reasons: for analyzing different accidental toxic release scenarios ("worst-case scenarios"), for preparing emergency response plans and optimal countermeasures as well as for real-time risk assessment and management (e.g. in the frame of the SEVESO directive). Depending on the demand and the particular purposes, the choice of the appropriate model is up to the authorities. The one year project was funded by the Austrian Science and research liaison Office (ASO, www.aso.zsi.at) as a part of the program: Research Cooperation and Networking between Austria, the public higher education institutions in Kosovo and South Eastern Europe. The project was conducted by the Central Institute for Meteorology and Geodynamics (ZAMG, http://www.zamg.ac.at) in cooperation with the University of Prishtina (Kosovo, www.uni-pr.edu and the National Institute of meteorology and Hydrology (NIHM Bulgaria, www.meteo.bg). One of the main purposes of the project was to provide the both partners with basic knowledge in modelling with accidental release of toxic gases, based on the practical experience of the meteorologists from the ZAMG in the area. This knowledge can be used as scientific response to society driven current or upcoming problems especially in Kosovo. The activities involved know-how transfer on European standards and practice among the project partners, as well as joint efforts to adapt and disseminate the scientific methods and results in Kosovo. Within the project, the partners from Kosovo and Bulgaria were introduced to the atmospheric dispersion model (ALOHA - Areal

  6. A mathematical model for predicting the probability of acute mortality in a human population exposed to accidentally released airborne radionuclides. Final report for Phase I of the project: early effects of inhaled radionuclides

    The report presents a mathematical model for the purpose of predicting the fraction of human population which would die within 1 year of an accidental exposure to airborne radionuclides. The model is based on data from laboratory experiments with rats, dogs and baboons, and from human epidemiological data. Doses from external, whole-body irradiation and from inhaled, alpha- and beta-emitting radionuclides are calculated for several organs. The probabilities of death from radiation pneumonitis and from bone marrow irradiation are predicted from doses accumulated within 30 days of exposure to the radioactive aerosol. The model is compared with existing similar models under hypothetical exposure conditions. Suggestions for further experiments with inhaled radionuclides are included

  7. Distinguishing cause from correlation in tokamak experiments to trigger edge-localised plasma instabilities

    Webster, Anthony J. [JET-EFDA, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); CCFE, Culham Science Centre, Abingdon OX14 3DB (United Kingdom)

    2014-11-15

    The generic question is considered: How can we determine the probability of an otherwise quasi-random event, having been triggered by an external influence? A specific problem is the quantification of the success of techniques to trigger, and hence control, edge-localised plasma instabilities (ELMs) in magnetically confined fusion (MCF) experiments. The development of such techniques is essential to ensure tolerable heat loads on components in large MCF fusion devices, and is necessary for their development into economically successful power plants. Bayesian probability theory is used to rigorously formulate the problem and to provide a formal solution. Accurate but pragmatic methods are developed to estimate triggering probabilities, and are illustrated with experimental data. These allow results from experiments to be quantitatively assessed, and rigorously quantified conclusions to be formed. Example applications include assessing whether triggering of ELMs is a statistical or deterministic process, and the establishment of thresholds to ensure that ELMs are reliably triggered.

  8. Globalisation, localisation and implications of a transforming nursing workforce in New Zealand: opportunities and challenges.

    Callister, Paul; Badkar, Juthika; Didham, Robert

    2011-09-01

    Severe staff and skill shortages within the health systems of developed countries have contributed to increased migration by health professionals. New Zealand stands out among countries in the Organisation for Economic Co-operation and Development in terms of the high level of movements in and out of the country of skilled professionals, including nurses. In New Zealand, much attention has been given to increasing the number of Māori and Pacific nurses as one mechanism for improving Māori and Pacific health. Against a backdrop of the changing characteristics of the New Zealand nursing workforce, this study demonstrates that the globalisation of the nursing workforce is increasing at a faster rate than its localisation (as measured by the growth of the Māori and New Zealand-born Pacific workforces in New Zealand). This challenges the implementation of culturally appropriate nursing programmes based on the matching of nurse and client ethnicities. PMID:21790871

  9. The effect of internal hydrogen on surface slip localisation on polycrystalline AISI 316L stainless steel

    A statistical analysis of the effect of internal hydrogen on the surface slip morphology of relatively high nickel content AISI 316L type austenitic stainless steel was carried out on high resolution data obtained by atomic force microscopy. Surface plastic strain localisation was studied for different hydrogen contents, two grain sizes, and two plastic strain levels. The height and spacing of approximately 8000 slip bands, observed on 12 specimens, are shown to follow log-normal distributions. Hydrogen increased the mean slip-band height and the mean slip-band spacing for the two macroscopic plastic strain levels considered, and for the two hydrogen concentrations in coarse-grained specimens. The hydrogen effect was also observed for fine-grained specimens, but only for the highest hydrogen concentration. In addition, the emerging dislocation velocity increased by a factor 3 for high hydrogen content.

  10. Pre-operative localisation of hyperfunctional parathyroid tissue with {sup 11}C-methionine PET

    Otto, D.; Boerner, A.R.; Hofmann, M.; Brunkhorst, T.; Meyer, G.J.; Petrich, T.; Knapp, W.H. [Hannover University Medical School, Department of Nuclear Medicine, Hannover (Germany); Scheumann, G.F. [Hannover University Medical School, Department of Visceral and Transplant Surgery, Hannover (Germany)

    2004-10-01

    Previous studies have shown high sensitivity of positron emission tomography (PET) with {sup 11}C-methionine in the pre-operative localisation of parathyroid adenoma and hyperplasia. Nonetheless, in secondary and tertiary hyperparathyroidism (HPT) and in patients with recurrent disease, pre-operative localisation of adenomatous (PTA) or hyperplastic tissue is still a problem with all available methods. The aim of this study was to define the optimal imaging protocol and to compare the diagnostic value of {sup 11}C-methionine PET and {sup 99m}Tc-methoxyisobutylisonitrile (MIBI) single-photon emission computed tomography (SPECT): in particular, we wished to define the benefit of {sup 11}C-methionine in those patients with inconclusive or negative conventional imaging. Thirty highly pre-selected patients with HPT were enrolled. Sixteen patients had primary HPT, 12 patients had secondary HPT, and two patients had recurrences of parathyroid carcinomas. All patients had ultrasound of the neck, dual-phase scintigraphy with {sup 99m}Tc-MIBI and PET with {sup 11}C-methionine. SUV{sub parathyroid}/SUV{sub cervical} {sub soft} {sub tissue} (target-to-background) and SUV{sub parathyroid} {sub tissue}/SUV{sub thyroid} {sub tissue} (target-to-non-target) ratios were calculated. After surgery, histology of specimens was obtained in all patients but one. In 12 patients with secondary or tertiary HPT, 36 hyperplastic parathyroid glands were histologically verified. Twenty-five of 36 lesions (69%) were detected with {sup 11}C-methionine PET and 17 (47%) with {sup 99m}Tc-MIBI scintigraphy. PET studies were positive in 17/18 (94%) cases in which HPT was related to adenomas or carcinomas. {sup 99m}Tc-MIBI scintigraphy/SPECT yielded pathological lesions in 9/18 cases (50%). All eight atypical localisations of parathyroid glands were detected with PET but only six of the eight were detected with {sup 99m}Tc-MIBI scintigraphy/SPECT. In 10/11 patients with recurrent HPT and non

  11. Control and mixing for 2D Navier-Stokes equations with space-time localised noise

    Shirikyan, Armen

    2011-01-01

    We consider randomly forced 2D Navier-Stokes equations in a bounded domain with smooth boundary. It is assumed that the random perturba- tion is non-degenerate, and its law is periodic in time and has a support localised with respect to space and time. Concerning the unperturbed problem, we assume that it is approximately controllable in infinite time by an external force whose support is included in that of the random force. Under these hypotheses, we prove that the Markov process generated by the restriction of solutions to the instants of time proportional to the period possesses a unique stationary distribution, which is exponentially mixing. The proof is based on a coupling argument, a local controllability property of the Navier-Stokes system, an estimate for the total variation distance between a measure and its image under a smooth mapping, and some classical results from the theory of optimal transport.

  12. Lyapounov exponents of products of random matrices: weak disorder expansion. Application to localisation

    Derrida, B.; Mecheri, K.; Pichard, J.L.

    1987-05-01

    We derive the weak disorder expansion of the Lyapounov exponents of a product of random matrices. The condition for this expansion to be valid is that in the limit of zero disorder, the matrix has all its eigenvalues with different moduli. As an example, we study the problem of localisation on strips in the limit of weak disorder. We show that our expansion agrees very well with numerical simulations in the region where the condition on the moduli is satisfied which corresponds to energies outside the conduction band. In that region, we find a limiting density of Lyapounov exponents when the strip width goes to infinity. Inside the band, our expansion cannot be valid unless one adds an imaginary part to the energy.

  13. Experimental simulation of Edge Localised Modes using focused electron beams - features of a circular load pattern

    The knowledge about degradation processes caused by Edge Localised Modes (ELMs) on plasma facing materials (PFMs) in future confinement experiments is essential to allow lifetime estimations for first wall and divertor components. Electron beam simulations of the occurring heat loads have the advantage to be able to work at higher frequencies compared to other experiments (e.g. plasma streams), allowing a large number of ELM-like heat pulses. This paper deals with the electron beam guidance method used in the JUDITH 2 facility in Forschungszentrum Juelich (Germany). As the beam is described well by a Gaussian profile with a variable FWHM, depending on several parameters, e.g. vacuum pressure, the guidance is of special interest in order to achieve an approximately homogeneous (ELM-like) loading. A circular pattern turned out to provide advantages, in particular related to an increased stability against beam width fluctuations.

  14. La synovite villonodulaire de la cheville, une localisation rare: à propos d'un cas

    Benabbouha, Abdellatif; Basinga, Jonathan; Anteri, Ismail; Jaafar, Abdelouab

    2016-01-01

    La synovite villonodulaire (SVN) est une prolifération pseudotumorale bénigne rare de la synoviale articulaire, d’étiologie inconnue. Elle peut aussi se développer au sein des bourses séreuses, des gaines tendineuses. Généralement, elle atteint les grosses articulations notamment le genou et la hanche. La localisation de la cheville est rare, avec seulement quelques cas publiés dans la littérature. Nous rapportons un cas de patiente de 52 ans présentant une SVN de la cheville droite. Elle a bénéficié d'une synovectomie subtotale. A deux ans de recul, il n'y avait pas de récidive clinique. PMID:27231502

  15. Distinguishing Cause from Correlation in Tokamak Experiments to Trigger Edge Localised Plasma Instabilities

    Webster, A J

    2014-01-01

    The generic question is considered: How can we determine the probability of an otherwise quasirandom event, having been triggered by an external influence? A specific problem is the quantification of the success of techniques to trigger, and hence control, edge-localised plasma instabilities (ELMs) in magnetically confined fusion (MCF) experiments. The development of such techniques is essential to ensure tolerable heat loads on components in large MCF fusion devices, and is necessary for their development into economically successful power plants. Bayesian probability theory is used to rigorously formulate the problem and to provide a formal solution. Accurate but pragmatic methods are developed to estimate triggering probabilities, and are illustrated with experimental data. These allow results from experiments to be quantitatively assessed, and rigorously quantified conclusions to be formed.

  16. Localised strain sensing of dielectric elastomers in a stretchable soft-touch musical keyboard

    Xu, Daniel; Tairych, Andreas; Anderson, Iain A.

    2015-04-01

    We present a new sensing method that can measure the strain at different locations in a dielectric elastomer. The method uses multiple sensing frequencies to target different regions of the same dielectric elastomer to simultaneously detect position and pressure using only a single pair of connections. The dielectric elastomer is modelled as an RC transmission line and its internal voltage and current distribution used to determine localised capacitance changes resulting from contact and pressure. This sensing method greatly simplifies high degree of freedom systems and does not require any modifications to the dielectric elastomer or sensing hardware. It is demonstrated on a multi-touch musical keyboard made from a single low cost carbon-based dielectric elastomer with 4 distinct musical tones mapped along a length of 0.1m. Loudness was controlled by the amount of pressure applied to each of these 4 positions.

  17. Filtres bayesiens appliqués à la localisation hybride de véhicules

    MOURLLION, B; Gruyer, D.; Aubert, D.

    2005-01-01

    L'étape de localisation précise d'un véhicule est nécessaire pour de nombreuses applications d'aides à la conduite et/ou d'automatisation. Afin de rendre robuste et fiable cette étape, nous sommes amené à utiliser différents capteurs et donc à fusionner différents flux d'informations. Les capteurs équipant le véhicule ont chacun leur propre fréquence de travail, fiabilité et précision. Parmi toutes les techniques disponibles, le filtrage de Kalman est la solution optimale dans le cas d'un mod...

  18. Fusion de données pour la localisation : approche multi-modèles

    NDJENG NDJENG, Alexandre

    2007-01-01

    La localisation hybride consiste à estimer l'état d'un véhicule (sa position, sa vitesse et son cap) à partir d'une fusion de données de capteurs proprioceptifs et extéroceptifs. Parmi les différentes techniques d'estimation d'états, le filtre de Kalman est présenté comme la seule méthode à pouvoir estimer l'erreur faite sur l'état et à être optimal au sens du minimum de variance lorsque le système est linéaire. En cas de non linéarités et en l'occurrence pour un véhicule routier, l'estimateu...

  19. Evaluation of localised corrosion behaviour of super austenitic stainless steels using dynamic electrochemical impedance spectroscopy

    Nagarajan, S.; Tamilselvi, S.; Rajendran, N. [Department of Applied Sciences and Humanities, MIT Campus, Anna University, Chromepet, Chennai-600 044, Tamil Nadu (India)

    2007-01-15

    Potentiodynamic polarisation and dynamic electrochemical impedance spectroscopic (DEIS) measurements were carried out in natural sea water on type 316L SS, Alloy 926 and Alloy 31. In order to study the localised corrosion resistance, the dynamic electrochemical impedance spectroscopy measurements were performed in a wide range of potentials covering corrosion potential (OCP or E{sub corr}), passive region, break down region and dissolution region. In this report we have shown that the impedance measurement in potentiodynamic condition allows simultaneous investigation of the changes in the passive layer structure and the ion transport process that occurs through the passive layer. The Nyquist plots were fitted using nonlinear least square (NLLS) method for different potential regions. Finally, the experimental results of polarisation data were found in good agreement with that of DEIS measurement. (Abstract Copyright [2007], Wiley Periodicals, Inc.)

  20. The fundamental role of localised vibrations in excitation dynamics in photosynthetic light-harvesting systems

    Kolli, Avinash; Scholes, Gregory D; Olaya-Castro, Alexandra

    2012-01-01

    The importance of fast vibrations in enhancing and controlling energy transfer and conversion in biomolecules is an issue of current debate. In this article we show that coupling between localised high-frequency vibrations and electronic degrees of freedom is fundamental for efficient excitation transport in photosynthetic light-harvesting systems with high degree of disorder. We consider the cryptophyte antennae protein phycoerythrin 545 and discuss how the balance between electronic interactions and coupling to fast vibronic modes supports the biological function of these antennae by generating a non-cascaded transport that leads to a rapid, directed and wider spatial distribution of excitation energy across the complex. Furthermore, we illustrate signatures of vibronic influence in the beating of excitonic coherences and show that mechanisms supporting coherent evolution of excitons also assist coupling to selected modes that enhance energy transfer to preferential sites in the complex. We therefore argue ...

  1. Extremely narrow spectrum of GRB110920A: further evidence for localised, subphotospheric dissipation

    Iyyani, S; Ahlgren, B; Burgess, J M; Larsson, J; Pe'er, A; Lundman, C; Axelsson, M; McGlynn, S

    2015-01-01

    Much evidence points towards that the photosphere in the relativistic outflow in GRBs plays an important role in shaping the observed MeV spectrum. However, it is unclear whether the spectrum is fully produced by the photosphere or whether a substantial part of the spectrum is added by processes far above the photosphere. Here we make a detailed study of the $\\gamma-$ray emission from single pulse GRB110920A which has a spectrum that becomes extremely narrow towards the end of the burst. We show that the emission can be interpreted as Comptonisation of thermal photons by cold electrons in an unmagnetised outflow at an optical depth of $\\tau \\sim 20$. The electrons receive their energy by a local dissipation occurring close to the saturation radius. The main spectral component of GRB110920A and its evolution is thus, in this interpretation, fully explained by the emission from the photosphere including localised dissipation at high optical depths.

  2. Localised $\\bf{AdS_5\\times S^5}$ Black Holes

    Dias, Oscar J C; Way, Benson

    2016-01-01

    We numerically construct asymptotically global $\\mathrm{AdS}_5\\times \\mathrm{S}^5$ black holes that are localised on the $\\mathrm{S}^5$. These are solutions to type IIB supergravity with $\\mathrm S^8$ horizon topology that dominate the theory in the microcanonical ensemble at small energies. At higher energies, there is a first-order phase transition to $\\mathrm{AdS}_5$-Schwarzschild$\\times \\mathrm{S}^5$. By the AdS/CFT correspondence, this transition is dual to spontaneously breaking the $SO(6)$ R-symmetry of $\\mathcal N=4$ super Yang-Mills down to $SO(5)$. We extrapolate the location of this phase transition and compute the expectation value of the resulting scalar operators in the low energy phase.

  3. Localisation d'énergie dans les protéines

    Juanico, Brice

    2007-01-01

    Afin de mettre en évidence le phénomène de localisation d'énergie dans les protéines, un modèle utilisant les concepts de la Physique non-linéaire a été développé. Il permet, via l'utilisation d'un potentiel de type FPU et d'une dissipation placée sur la surface, de faire apparaître des breathers chaotiques dans certaines enzymes. Ces breathers ont une durée de vie importante par rapport aux échelles de temps caractéristiques du système. Ils sont localisés sur un seul résidu, toujours situé d...

  4. Localisation of the monocyte-binding region on human immunoglobulin G.

    Woof, J M; Partridge, L J; Jefferis, R; Burton, D R

    1986-03-01

    Earlier studies, which provided indirect evidence for the involvement of the C gamma 2 domain of human immunoglobulin G (IgG) in human immunoglobulin G (IgG) in human monocyte binding, have been extended to further localise the site of interaction on human IgG. A number of IgGs from several different species and fragments of human IgGs were assayed for ability to inhibit the interaction of radio-labelled human IgG and the human monocyte. By comparison of the amino-acid sequences of those IgGs found to exhibit relatively tight, intermediate or weak binding to human monocyte Fc receptors we are able to postulate a possible monocyte-binding site on human IgG. In addition, the results have implications for the applicability of monoclonal antibodies and antisera when used in the presence of human monocytes and possibly macrophages. PMID:3487030

  5. Localisation of a channel instability in a BWR via neutron noise methods

    A special type of instability occurred in the Swedish BWR Forsmark 1 in 1996. In contrast to the better known global or regional (out-of-phase) instabilities, the decay ratio appeared to be very high in one half of the core and quite low in the other half. A more detailed analysis showed that the most likely reason for the observed behaviour is a local perturbation of thermohydraulic character, e.g. a density wave oscillation (DWO), induced by the incorrect positioning of a fuel assembly (an 'unseated' assembly). In such a case it is of large importance to determine the position of the unseated assembly already during operation such that it can be easily found during reloading. The subject of this paper is to report on development and application of methods by which the position of such a local perturbation can be determined. Two different methods that support and complement each other were used. First a visualisation technique was elaborated which expedites a very good qualitative comprehension of the situation and which can be useful for the operators. It also gives an important basis for the application of the localisation algorithm. Second, a quantitative (algorithmic) localisation method, suited for this type of perturbation, was elaborated. This latter takes noise spectra from selected detectors as input and yields the perturbation position as output. The method was tested on simulated data, and then applied to the Forsmark measurements. The location of the disturbance, found by the algorithm, is in accordance with independent judgements for the case, and close to a position where an unseated assembly was found during refuelling. (author)

  6. Expression and localisation of BDNF, NT4 and TrkB in proliferative vitreoretinopathy.

    Ghazi-Nouri, Seyed M S; Ellis, James S; Moss, Stephen; Limb, G Astrid; Charteris, David G

    2008-05-01

    Exogenous brain derived neurotrophic factor (BDNF) is known to rescue ganglion cell death after optic nerve injury. Its mechanism of action is believed to be indirect via glial cells in the retina. In this study we investigated the changes in expression and localisation of BDNF, neurotrophin-4 (NT4) and their common receptor (TrkB) in retinectomy sections of patients with proliferative vitreoretinopathy (PVR). Nine full-thickness retinectomy specimens obtained at retinal reattachment surgery for PVR were fixed in 4% paraformaldehyde immediately after excision and compared to similarly processed normal donor retinas (4 eyes). Agarose-embedded sections (100 microm thick) were double labelled for immunohistochemistry by confocal microscopy, with antibodies against BDNF, NT4, TrkB, rod opsin, glial fibrillary acidic protein (GFAP), cellular retinaldehyde binding protein (CRALBP) and Brn3. This study demonstrates expression of NT4 by ganglion cells and shows expression of BDNF and NT4 in the outer photoreceptor segments is downregulated during PVR, whilst NT4 is markedly upregulated throughout the retina during this condition. The findings here suggest that NT4 may play a neural protective role during the development of PVR. It also shows that upregulation of NT4 in PVR is localised to Müller glial cells, indicating either over-expression of this factor by Müller cells or that Müller cells internalise NT4 for trafficking across the retina. TrkB expression was not observed in PVR retina. The observations that Müller glia demonstrate upregulation of NT4 suggests that retinal injury may lead to activation of this neurotrophin by Müller cells as part of their neuroprotective functions. PMID:18405896

  7. Controlling factors in localised corrosion morphologies observed for magnesium immersed in chloride containing electrolyte.

    Williams, Geraint; Birbilis, Nick; McMurray, H Neil

    2015-01-01

    The early stages of localised corrosion affecting magnesium (Mg) surfaces when immersed in aqueous sodium chloride (NaCl) solutions involves the propagation of dark regions, within which both anodic metal dissolution and cathodic hydrogen evolution occur. For nominally "pure" Mg, these dark areas can either take the form of discs which expand radially with time, or filiform-like tracks which lengthen with time. For Mg surfaces which display disc-form corrosion features in concentrated NaCl electrolyte, a transition to filiform corrosion (FFC) is observed as the concentration is decreased, indicating ohmic constraints on radial propagation. A similar effect is observed when Mg specimens of different iron impurity are immersed in a fixed, high concentration NaCl solution, where disc-form corrosion is observed on samples having ≥280 ppm Fe, but FFC predominates at ≤80 ppm Fe. An in situ scanning vibrating electrode technique (SVET) is used to determine current density distributions within the propagating corrosion features. Cathodic current density values of between -100 and -150 A m(-2) measured in central areas of disc-like features are sufficient to sustain the radial growth of a local anode at the perimeter of the discs. However, for high purity Mg specimens (≤80 ppm Fe), cathodic current densities of -10 A m(-2) or less are measured over FFC affected regions, indicating that linear propagation arises when there is insufficient cathodic current produced on the corroded surface to sustain radial growth. The results are consistent with surface control of localised corrosion propagation in concentrated electrolyte, but ohmic control in dilute, lower conductivity NaCl solution. PMID:25910069

  8. Evaluation of cytotoxicity profile and intracellular localisation of doxorubicin-loaded chitosan nanoparticles.

    Souto, Gabriele Dadalt; Farhane, Zeineb; Casey, Alan; Efeoglu, Esen; McIntyre, Jennifer; Byrne, Hugh James

    2016-08-01

    In the emerging field of nanomedicine, targeted delivery of nanoparticle encapsulated active pharmaceutical ingredients (API) is seen as a potential significant development, promising improved pharmacokinetics and reduced side effects. In this context, understanding the cellular uptake of the nanoparticles and subsequent subcellular distribution of the API is of critical importance. Doxorubicin (DOX) was encapsulated within chitosan nanoparticles to investigate its intracellular delivery in A549 cells in vitro. Unloaded (CS-TPP) and doxorubicin-loaded (DOX-CS-TPP) chitosan nanoparticles were characterised for size (473 ± 41 nm), polydispersity index (0.3 ± 0.2), zeta potential (34 ± 4 mV), drug content (76 ± 7 μM) and encapsulation efficiency (95 ± 1 %). The cytotoxic response to DOX-CS-TPP was substantially stronger than to CS-TPP, although weaker than that of the equivalent free DOX. Fluorescence microscopy showed a dissimilar pattern of distribution of DOX within the cell, being predominantly localised in the nucleus for free form and in cytoplasm for DOX-CS-TPP. Confocal microscopy demonstrated endosomal localisation of DOX-CS-TPP. Numerical simulations, based on a rate equation model to describe the uptake and distribution of the free DOX, nanoparticles and DOX-loaded nanoparticles within the cells and the subsequent dose- and time-dependent cytotoxic responses, were used to further elucidate the API distribution processes. The study demonstrates that encapsulation of the API in nanoparticles results in a delayed release of the drug to the cell, resulting in a delayed cellular response. This work further demonstrates the potential of mathematical modelling in combination with intracellular imaging techniques to visualise and further understand the intracellular mechanisms of action of external agents, both APIs and nanoparticles in cells. PMID:27225177

  9. Histochemical localisation of carbonic anhydrase in the inner ear of developing cichlid fish, Oreochromis mossambicus

    Beier, M.; Hilbig, R.; Anken, R.

    2008-12-01

    Inner ear otolith growth in terms of mineralisation mainly depends on the enzyme carbonic anhydrase (CAH). CAH is located in specialised, mitochondria-rich macular cells (ionocytes), which are involved in the endolymphatic ion exchange, and the enzyme is responsible for the provision of the pH-value necessary for otolithic calcium carbonate deposition. In the present study, for the first time the localisation of histochemically demonstrated CAH was analysed during the early larval development of a teleost, the cichlid fish Oreochromis mossambicus. CAH-reactivity was observed already in stage 7 animals (onset of otocyst development; staging follows Anken et al. [Anken, R., Kappel, T., Slenzka, K., Rahmann, H. The early morphogenetic development of the cichlid fish, Oreochromis mossambicus (Perciformes, Teleostei). Zool. Anz. 231, 1-10, 1993]). Neuroblasts (from which sensory and supporting cells are derived) proved to be CAH-positive. Already at stage 12 (hatch), CAH-positive regions could be attributed to ionocyte containing regions both in the so-called meshwork and patches area of the macula (i.e., clearly before ionocytes can be identified on ultrastructural level or by employing immunocytochemistry). In contrast to the circumstances observed in mammalian species, sensory hair cells stained negative for CAH in the cichlid. With the onset of stage 16 (finray primordia in dorsal fin, yolk-sac being increasingly absorbed), CAH-reactivity was observed in the vestibular nerve. This indicates the onset of myelinisation and thus commencement of operation. The localisation of CAH in the inner ear of fish (especially the differences in comparison to mammals) is discussed on the basis of its role in otolith calcification. Since the vestibular system is a detector of acceleration and thus gravity, also aspects regarding effects of altered gravity on CAH and hence on the mineralisation of otoliths in an adaptive process are addressed.

  10. Correlative and integrated light and electron microscopy of in-resin GFP fluorescence, used to localise diacylglycerol in mammalian cells

    Peddie, Christopher J.; Blight, Ken; Wilson, Emma [Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Melia, Charlotte [Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Cell Biophysics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Department of Molecular Cell Biology, Leiden University Medical Centre, 2300 RC Leiden (Netherlands); Marrison, Jo [Department of Biology, The University of York, Heslington, York (United Kingdom); Carzaniga, Raffaella [Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Domart, Marie-Charlotte [Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Cell Biophysics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); O' Toole, Peter [Department of Biology, The University of York, Heslington, York (United Kingdom); Larijani, Banafshe [Cell Biophysics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Cell Biophysics Laboratory, Unidad de Biofísica (CSIC-UPV/EHU),Sarriena s/n, 48940 Leioa (Spain); IKERBASQUE, Basque Foundation for Science, Bilbao (Spain); Collinson, Lucy M. [Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom)

    2014-08-01

    Fluorescence microscopy of GFP-tagged proteins is a fundamental tool in cell biology, but without seeing the structure of the surrounding cellular space, functional information can be lost. Here we present a protocol that preserves GFP and mCherry fluorescence in mammalian cells embedded in resin with electron contrast to reveal cellular ultrastructure. Ultrathin in-resin fluorescence (IRF) sections were imaged simultaneously for fluorescence and electron signals in an integrated light and scanning electron microscope. We show, for the first time, that GFP is stable and active in resin sections in vacuo. We applied our protocol to study the subcellular localisation of diacylglycerol (DAG), a modulator of membrane morphology and membrane dynamics in nuclear envelope assembly. We show that DAG is localised to the nuclear envelope, nucleoplasmic reticulum and curved tips of the Golgi apparatus. With these developments, we demonstrate that integrated imaging is maturing into a powerful tool for accurate molecular localisation to structure. - Highlights: • GFP and mCherry fluorescence are preserved in heavy-metal stained mammalian cells embedded in resin • Fluorophores are stable and intensity is sufficient for detection in ultrathin sections • Overlay of separate LM and EM images from the same ultrathin section improves CLEM protein localisation precision • GFP is stable and active in the vacuum of an integrated light and scanning EM • Integrated light and electron microscopy shows new subcellular locations of the lipid diacylglycerol.

  11. Correlative and integrated light and electron microscopy of in-resin GFP fluorescence, used to localise diacylglycerol in mammalian cells

    Fluorescence microscopy of GFP-tagged proteins is a fundamental tool in cell biology, but without seeing the structure of the surrounding cellular space, functional information can be lost. Here we present a protocol that preserves GFP and mCherry fluorescence in mammalian cells embedded in resin with electron contrast to reveal cellular ultrastructure. Ultrathin in-resin fluorescence (IRF) sections were imaged simultaneously for fluorescence and electron signals in an integrated light and scanning electron microscope. We show, for the first time, that GFP is stable and active in resin sections in vacuo. We applied our protocol to study the subcellular localisation of diacylglycerol (DAG), a modulator of membrane morphology and membrane dynamics in nuclear envelope assembly. We show that DAG is localised to the nuclear envelope, nucleoplasmic reticulum and curved tips of the Golgi apparatus. With these developments, we demonstrate that integrated imaging is maturing into a powerful tool for accurate molecular localisation to structure. - Highlights: • GFP and mCherry fluorescence are preserved in heavy-metal stained mammalian cells embedded in resin • Fluorophores are stable and intensity is sufficient for detection in ultrathin sections • Overlay of separate LM and EM images from the same ultrathin section improves CLEM protein localisation precision • GFP is stable and active in the vacuum of an integrated light and scanning EM • Integrated light and electron microscopy shows new subcellular locations of the lipid diacylglycerol

  12. Three-Dimensional Passive Source Localisation using the Flank Array of an Autonomous Underwater Vehicle in Shallow Water

    Dexin Zhao

    2013-05-01

    Full Text Available Researchers have become interested in autonomous underwater vehicles equipped with various kinds of sonar systems that can perform many of underwater tasks, which is encouraged by the potential benefits of cost reduction and flexible deployment. This paper proposes an approach to three-dimensional passive source localisation with the flank array of an autonomous underwater vehicle in shallow water. The approach is developed based on matched-field processing for the likelihood of passive source localisation in the shallow water environment. Inter-position processing is also used for the improved localisation performance and the enhanced stability of the estimation process against the lack of spatial gain due to the small physical size of the flank array. The proposed approach is presented and validated through simulation and experimental data. The results illustrate the localisation performance at different signal-to-noise ratios and demonstrate the build up over time of the positional parameters of the estimated source as the autonomous underwater vehicle cruises at a low speed along a straight line at a constant depth.

  13. Three-Dimensional Passive Source Localisation using the Flank Array of an Autonomous Underwater Vehicle in Shallow Water

    Dexin Zhao

    2013-05-01

    Full Text Available Researchers have become interested in autonomous underwater vehicles equipped with various kinds of sonar systems that can perform many of underwater tasks, which is encouraged by the potential benefits of cost reduction and flexible deployment. This paper proposes an approach to three-dimensional passive source localisation with the flank array of an autonomous underwater vehicle in shallow water. The approach is developed based on matched-field processing for the likelihood of passive source localisation in the shallow water environment. Inter-position processing is also used for the improved localisation performance and the enhanced stability of the estimation process against the lack of spatial gain due to the small physical size of the flank array. The proposed approach is presented and validated through simulation and experimental data. The results illustrate the localisation performance at different signal-to-noise ratios and demonstrate the build up over time of the positional parameters of the estimated source as the autonomous underwater vehicle cruises at a low speed along a straight line at a constant depth.Defence Science Journal, 2013, 63(3, pp.323-330, DOI:http://dx.doi.org/10.14429/dsj.63.3011

  14. Probabilistic analysis of safety in industrial irradiation plants

    The Argentinean Nuclear Regulatory Authority is carrying out the Probabilistic Safety Analysis (PSA) of the two industrial irradiation plants existent in the country. The objective of this presentation is to show from the regulatory point of view, the advantages of applying this tool, as well as the appeared difficulties; for it will be made a brief description of the facilities, of the method and of the normative one. Both plants are multipurpose facilities classified as 'industrial irradiator category IV' (panoramic irradiator with source deposited in pool). Basically, the execution of an APS consists of the following stages: 1. Identification of initiating events. 2. Modeling of Accidental Sequences (Event Trees). 3. Analysis of Systems (Fault trees). 4. Quantification of Accidental Sequences. The argentine normative doesn't demand to these facilities the realization of an APS, however the basic standard of Radiological Safety establishes that in the design of this type of facilities in the cases that is justified, should make sure that the annual probability of occurrence of an accidental sequence and the resulting dose in a person gives as result an radiological risk inferior to the risk limit adopted as acceptance criteria. On the other hand the design standard specifies for these irradiators it demands a maximum fault rate of 10-2 for the related components with the systems of radiological safety. In our case, the possible initiating events have been identified that carried out to not wanted situations (about people exposure, radioactive contamination). Then, for each one of the significant initiating events, the corresponding accidental sequences were modeled and the safety systems that intervene in this sequences by means of fault trees were analyzed, for then to determine the fault probabilities of the same ones. At the moment they are completing these fault trees, but the difficulty resides in the impossibility of obtaining real data of the reliability

  15. Effet de l'interaction coulombienne sur la localisation d'Anderson dans le gaz bidimensionnel d'électrons

    Fleury, G.

    2010-09-01

    Nous étudions l’effet des interactions coulombiennes sur la localisation d’Anderson dans le gaz bidimensionnel d’électrons désordonné. L’objectif est de statuer sur la question de l’existence de métaux à deux dimensions. En l’absence d’interaction, la théorie d’échelle de la localisation prédit qu’un désordre infinitésimal suffit à localiser la fonction d’onde électronique et donc à rendre le système isolant à température nulle (Abrahams et al., 1979). Dans certaines limites extrêmes, les interactions peuvent être prises en compte et l’on aboutit également à un état isolant. Cependant, aucune théorie analytique ne permet de traiter le régime quantique non-perturbatif où désordre et interaction sont intermédiaires. Expérimentalement, il est possible de l’explorer dans des échantillons de haute mobilité et basse densité. Depuis 1994, des comportements métalliques inexpliqués y ont été observés (Kravchenko et al., 1994). Nous avons mis au point une méthode numérique permettant d’étudier le problème couplé de la localisation d’Anderson en présence d’interaction. Cette méthode mêle Monte Carlo quantique à température nulle et théorie d’échelle pour la conductance de Thouless. Nous trouvons que la théorie d’échelle de la localisation est préservée en présence d’interaction et donc que le gaz bidimensionnel, même corrélé, est isolant à température nulle. Nos résultats montrent de plus que les interactions délocalisent le gaz bidimensionnel et que cet effet de délocalisation est accru en présence de dégénérescence de vallées. Ils nous permettent de proposer un mécanisme simple rendant compte des principales caractéristiques des comportements métalliques observés expérimentalement.

  16. Accidentes de tráfico, víctimas mortales y consumo de alcohol

    Arranz Muñoz, José María; Gil, Ana Isabel

    2006-01-01

    Clasificación JEL: C3, H2, I1, R4. El objetivo de este artículo es analizar la relación existente entre los precios de las bebidas alcohólicas, el consumo de alcohol y los accidentes mortales de tráfico a partir de datos de las comunidades autónomas españolas durante el periodo 1998-2002. Entre los principales resultados de la investigación se aprecia una correlación positiva entre el consumo de alcohol y el ratio de accidentes mortales de tráfico. Además, las acciones dirigidas a modif...

  17. LA RECONSTRUCCIÓN DE ACCIDENTES DE TRÁFICO. SIRAT 2014

    Dols Ruiz, Juan Francisco

    2014-01-01

    La reconstrucción de los accidentes de tráfico y el análisis de las causas que los han provocado, se ha convertido en una de las técnicas y metodologías más eficaces para la selección óptima de las políticas de prevención de accidentes de tráfico por parte de las autoridades. En relación con la seguridad vial, este ha sido durante las últimas décadas uno de los objetivos de la administración con objeto de reducir la siniestralidad en las carreteras y la reducción de sus consecuencias, tanto s...

  18. Analyses of postulated accidental releases of UF6 inside process buildings

    Uranium Hexafluoride is a material used in the various processes which comprise the front end of the nuclear fuel cycle (conversion, enrichment and fuel fabrication). Confinement of UF6 is a very important safety requirement since this material is highly reactive and presents safety hazards to humans. The present paper discusses the safety relevant aspects of accidental releases of UF6 inside process confinement buildings. Postulated accidental scenarios are analyzed and their consequences evaluated. Implant releases rates are estimated using computer code predictions. A time dependent homogeneous compartment model is used to predict concentrations of UF6, hydrogen fluoride and uranyl fluoride inside a confinement building, as well as to evaluate source terms released to the atmosphere. These source terms can be used as input to atmospheric dispersion models to evaluate consequences to the environment. The results can also be used to define adequate protective measures for emergency situations. (author)

  19. Modelling accidental releases of carbon 14 in the environment: application as an excel spreadsheet

    An application as an Excel spreadsheet of the simplified modelling approach of carbon 14 transfer in the environment developed by Tamponnet (2002) is presented. Based on the use of growth models of biological systems (plants, animals, etc.), the one-pool model (organic carbon) that was developed estimates the concentration of carbon 14 within the different compartments of the food chain and in fine the dose to man by ingestion in the case of a chronic or accidental release of carbon 14 in a river or the atmosphere. Data and knowledge have been implemented on Excel using the object-oriented programming language VisualBasic (Microsoft Visual Basic 6.0). The structure of the conceptual model and the Excel sheet are first briefly exposed. A numerical application of the model under a scenario of an accidental release of carbon 14 in the atmosphere is then presented. Simulation results and perspectives are discussed. (author)

  20. Modelling accidental releases of tritium in the environment: application as an excel spreadsheet

    An application as an Excel spreadsheet of the simplified modelling approach of tritium transfer in the environment developed by Tamponnet (2002) is presented. Based on the use of growth models of biological systems (plants, animals, etc.), the two-pool model (organic tritium and tritiated water) that was developed estimates the concentration of tritium within the different compartments of the food chain and in fine the dose to man by ingestion in the case of a chronic or accidental release of tritium in a river or the atmosphere. Data and knowledge have been implemented on Excel using the object-oriented programming language VisualBasic (Microsoft Visual Basic 6.0). The structure of the conceptual model and the Excel sheet are first briefly exposed. A numerical application of the model under a scenario of an accidental release of tritium in the atmosphere is then presented. Simulation results and perspectives are discussed. (author)