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Sample records for accidental laboratory exposures

  1. Epidemiology of accidental radiation exposures.

    Cardis, E

    1996-01-01

    Much of the information on the health effects of radiation exposure available to date comes from long-term studies of the atomic bombings in Hiroshima and Nagasaki. Accidental exposures, such as those resulting from the Chernobyl and Kyshtym accidents, have as yet provided little information concerning health effects of ionizing radiation. This paper will present the current state of our knowledge concerning radiation effects, review major large-scale accidental radiation exposures, and discu...

  2. Management of accidental exposure to Ebola virus in the biosafety level 4 laboratory, Hamburg, Germany.

    Günther, Stephan; Feldmann, Heinz; Geisbert, Thomas W; Hensley, Lisa E; Rollin, Pierre E; Nichol, Stuart T; Ströher, Ute; Artsob, Harvey; Peters, Clarence J; Ksiazek, Thomas G; Becker, Stephan; ter Meulen, Jan; Olschläger, Stephan; Schmidt-Chanasit, Jonas; Sudeck, Hinrich; Burchard, Gerd D; Schmiedel, Stefan

    2011-11-01

    A needlestick injury occurred during an animal experiment in the biosafety level 4 laboratory in Hamburg, Germany, in March 2009. The syringe contained Zaire ebolavirus (ZEBOV) mixed with Freund's adjuvant. Neither an approved treatment nor a postexposure prophylaxis (PEP) exists for Ebola hemorrhagic fever. Following a risk-benefit assessment, it was recommended the exposed person take an experimental vaccine that had shown PEP efficacy in ZEBOV-infected nonhuman primates (NHPs) [12]. The vaccine, which had not been used previously in humans, was a live-attenuated recombinant vesicular stomatitis virus (recVSV) expressing the glycoprotein of ZEBOV. A single dose of 5 × 10(7) plaque-forming units was injected 48 hours after the accident. The vaccinee developed fever 12 hours later and recVSV viremia was detectable by polymerase chain reaction (PCR) for 2 days. Otherwise, the person remained healthy, and ZEBOV RNA, except for the glycoprotein gene expressed in the vaccine, was never detected in serum and peripheral blood mononuclear cells during the 3-week observation period. PMID:21987751

  3. The Frequency of the Accidental Contamination with Laboratory Samples in Yazd Clinical Laboratories’ personnel in 2011

    Jafari, AA. (PhD

    2014-05-01

    Full Text Available Background and Objective: laboratory personnel have always accidental exposure to clinical samples, which can cause the transmission of infection. This threat can be prevented and controlled by education for the use of safety instruments. The purpose was to determine the frequency of accidental exposure to laboratory samples among Yazd laboratory personnel in 2011. Material and Methods: This descriptive cross-sectional study was conducted on 100 of Yazd clinical laboratory personnel. The data was collected, using a valid and reliable questioner, via interview and analyzed by means of SPSS software. Results: Eighty-six percent of the subjects reported an experience of accidental exposure to clinical samples, such as blood, serum and urine. The causes were carelessness (41% and work overload (29%. Needle- stick was the most prevalent injury (52% particularly in sampler workers (51% and in their hands (69%. There wasn’t significant relationship between accidental exposure to laboratory samples and the variables such as private and governmental laboratories (p=0.517, kind of employment (p=0.411, record of services (p=0.439 and academic degree (p=0.454. The subjects aged 20-29 (p=0.034 and worked in sampling unit had the highest accidental exposure. Conclusion: based on the results, inexperience of the personnel especially in sampling room, overload at work and ignorance of applying safety instruments are known as the most important reasons for accidental exposure to clinical samples. Keywords: Contamination; accidental Exposure; Infectious agents; laboratory; personnel

  4. Dosimetric significance of cytogenetic examinations in human accidental over exposures

    The damage to 13 workers following accidental exposures was assessed from lymphocyte chromosomal aberrations, and the results compared with those supplied by physical dosimetry and the clinical syndromes

  5. Lessons learned from accidental exposures in radiotherapy

    The medical use of radiation is unique in that patients are intentionally exposed to radiation. The aim in radiation therapy is twofold: to deliver a dose and dose distribution that is adequate for tumour control, but which also minimizes complications in normal tissues. In therapeutic applications, the doses are high and a deviation from the prescribed dose may have severe or even fatal consequences. There is therefore a great need to ensure adequate radiation protection and safety in radiotherapy by verifying that all personnel involved are appropriately trained for their duties, that the equipment used meets relevant international specifications for radiation safety and that safety culture is embedded in routine activities in radiotherapy departments. Many individuals must interact and work together on highly technical measurements and calculations, and therefore the potential for mistakes is great. A review of the mistakes shows that most are due to human error. The International Basic Safety Standards for Protection against Ionizing Radiation and the Safety of Radiation Sources (IAEA Safety Series No. 115) require that a prompt investigation be conducted whenever an accidental medical exposure of patients occurs. The report of the investigation is to be disseminated to the appropriate parties so that lessons can be learned to prevent similar accidents or mitigate their consequences in the future. This Safety Report is a collection of a large number of events that may serve as a checklist against which to test the vulnerability of a facility to potential accidents, and to provide a basis for improving safety in the use of radiation in medical applications. A further purpose of this report is to encourage readers to develop a questioning and learning attitude, adopt measures for the prevention of accidents, and prepare for mitigation of the consequences of accidents if they occur

  6. Cytogenetic biological dosimetry. Dose estimative in accidental exposure

    The methodology of cytogenetic biological dosimetry is studied. The application in estimation of dose in five cases of accidental exposure is reported. An hematological study and culture of lymphocytes is presented. (M.A.C.)

  7. Quality control for handling of accidental blood exposures.

    Wijk, P.T. van; Pelk-Jongen, M.; Wijkmans, C.; Voss, A.; Schneeberger, P.M.

    2006-01-01

    A regional counselling service was established to handle all accidental blood exposures using a standardized protocol. Levels of risk were assessed using an algorithm. Accidents that posed a risk for the transmission of hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV) were

  8. The accidental exposure to ionizing radiations

    This article is divided in three parts, the first one gives the radioactivity sources, the doses and the effects, the second part is devoted to the medical exposures, the third part concerns the accidents and the biological effects of an irradiation the different syndromes ( the acute whole-body irradiation syndrome, the localized irradiation syndrome, the inflammatory syndrome, hematopoietic syndrome,neuro-vascular syndrome) are detailed. (N.C.)

  9. Accidental over-exposure from dental X-ray equipment

    A description is given of an unusual dental X-ray procedure which resulted in accidental over-exposure both to the dentist and to several of his patients when a short-circuit was present in newly-installed equipment. The short-circuit by-passed the exposure control and energized the tube for certain orientations of the X-ray tube. The dentist left the patients, who wore protective aprons, to initiate the exposure themselves, using the control button. Although the warning lights were on, the dentist was not present in the room during the exposure, and the over-exposures were only detected when the developed X-ray films were found to be completely blackened. A reconstruction of the procedure enabled estimates to be made of the dose equivalents to the dentist's body and to the skin of the head, the eyes and the gonads of the patients. The dentist had overlooked several of basic principles recommended in the Code of Practice for the Protection of Persons against Ionizing Radiations from Medical and Dental Use (1972). It is pointed out that incidents involving failure of dental equipment (usually the timer mechanism) are not infrequent. (U.K.)

  10. Dose assessment of an accidental exposure at the IPNS

    Seven different methods were used to estimate the dose rate to a female worker who was accidentally exposed in the neutron PHOENIX beamline at the IPNS. Theoretical and measured entrance dose ranged from 550 mrem/min to 2850 mrem/min. Theoretical estimates were based on a Monte Carlo simulation of a spectrum provided by IPNS (Crawford Spectrum). Dose measurements were made with TLDs on phantoms and with ionization chambers in a water phantom. Estimates of the whole body total effective dose equivalent (TEDE) rate ranged from 5.2 mrem/min to 840 mrem/min. Assumed and measured quality factors ranged from 2.6 to 11.8. Cytogenetic analyses of blood samples detected no positive exposure. The recommended TEDE rate was 158 mrem/min. The TEDE was 750 mrem

  11. Nodular goiter after occupational accidental exposure to radiation

    Pisarev, M.A. [Radiobiology, National Atomic Energy Commission, Buenos Aires (Argentina); Human Biochemistry, Uninversity of Buenos Aires, School of Medicine, Buenos Aires (Argentina); Schnitman, M. [Center of Endocrinology and Metabolism, French Hospital C.Milstein, Buenos Aires (Argentina)

    2012-07-01

    In the present paper we present the consequences of an accidental occupational radiation exposure at a local hospital in Buenos Aires. Control at a local radiology service showed the lack of correct shielding in the X-ray equipment. The physicians and technicians (14 persons) exposed to radiation during 12 months were examined. The survey shows that: a) In 11 out of 14 radiation-exposed patients nodular goiter developed and an additional patient had diffuse goiter which means a goiter incidence of 85.7%; b) In 5 of the nodular goiter patients an increase in the size or the appearance of new nodules was observed along the follow-up period. No cancer was detected by FNA; c) Hypothyroidism was observed in 3/14 patients, and an additional patient had an abnormal TRH-TSH test, suggesting subclinical hypothyroidism; and d) Increased circulating antithyroid antibodies were found in one of the hypothyroid patients

  12. Concept of radiological, medical and social protection of the population of Russia affected by accidental exposure

    Main principles of population radiation protection from various accidental exposure, including the Chernobyl accident, have been implemented in officially approved Concept ''On radiological, medical, social protection and rehabilitation of the Russian Federation population affected by accidental radiation exposure''. The concept includes basic principles of radiation protection, designation of regional radionuclide contaminated territories, records and registers of exposed persons, health protection and rehabilitation, socio-economic and legal aspects

  13. Early diagnosis and monitoring of whole-body accidental exposure

    This paper deals with the handling of accidental, acute or protracted, whole-body overexposures. It is complementary to the report DPS 86/07 SEAPS previously published. The criteria for initial classification, as a function of the mean absorbed dose, the clinical and paraclinical evaluation, the monitoring methods and the treatments to undertake are described successively. The basic components of the therapy are the intensive care of the hematological syndrome with blood products transfusions and anti-infection prophylaxy. The indications and conditions for bone-marrow grafts are also discussed

  14. Clinical study of lesions caused by accidental local exposure to ionizing radiations

    During the last few years the radiopathology service of the Curie Foundation has admitted more than a hundred patients who were followed and treated for irradiation or suspected irradiation after a work accident. Accidents followed by clinical symptoms account for about half the cases examined. Some of these clinical signs were benign whereas others developed very seriously, all possible conditions between these two extremes being represented. This report neglects cases of high total exposure and deals only with those of partial irradiation where local symptoms predominate, usually at the distal extremities of the upper limbs and exceptionally at the root or distal extremity of the lower limbs. Six clinical cases were selected as particularly revealing and are discussed below: accidental exposure of both hands to an iridium-192 source; chronic exposure to X-rays (left hand and right lower half-lip); accidental exposure of the right hand and antero-external face of the right thigh to a iridium-192 source; acute accidental exposure of the left hand to X-rays emitted under 50 kV; accidental exposure of both hands to cobalt-60 radiation; radiolesions of the left lower limb following a critical power excursion (gamma rays and neutrons)

  15. Individual dosimetry in planned, existing and accidental exposure situations

    There are three types of radiation exposure which include Planned exposure situations, Existing exposure situations and Emergency exposure situations which are defined as Situations that may occur during the operation of a planned situation, or from a malicious act, or from any other unexpected situation, and require urgent action in order to avoid or reduce undesirable consequences. A given individual may be exposed as a worker, and/or as a member of the public, and/or as a patient. Workers in medical professions involving radiation are occupationally exposed. For individual monitoring of exposed workers, Film badges or thermo luminescence dosimeters are in use. In cases where individual may be suspected to be contaminated internally, contamination monitors are used to monitor the site and whole body counters to monitor individuals. Members of the public are exposure to cosmic rays during air flights. Film badges were used to exposure of workers to NORM during maintenance work in old oil field. TLD is used for exposure workers in nuclear medicine department. Any radiation accident will add knowledge and experience. Accidents from lost, stolen or neglected sources are particularly special because the radiation exposure patterns of the individuals involved and the scenario of the accident are always different

  16. Adverse events in humans associated with accidental exposure to the livestock brucellosis vaccine RB51.

    Ashford, David A; di Pietra, Jennifer; Lingappa, Jairam; Woods, Christopher; Noll, Heather; Neville, Bridget; Weyant, Robbin; Bragg, Sandra L; Spiegel, Richard A; Tappero, Jordan; Perkins, Bradley A

    2004-09-01

    Brucella abortus strain RB51 vaccine, is an attenuated live bacterial vaccine that was licensed conditionally by the Center for Veterinary Biologics, Veterinary Services, Animal and Plant Health Inspection Service, USDA, on 23 February 1996, for vaccination of cattle in the United States. Accidental human inoculations can occur during vaccination of cattle, and previous live Brucella vaccines designed for cattle have been known to cause brucellosis in humans. The Centers for Disease Control and Prevention (CDC) established passive surveillance for accidental inoculation with the RB51 vaccine in the United States to determine if this veterinary vaccine is associated with human disease, to describe the circumstances of accidental inoculation, to evaluate the potential efficacy of post-exposure chemoprophylaxis, and to develop recommendations for post-exposure management following exposure to RB51. Reports were received from 26 individuals. Accidental exposure to RB51 occurred by needle stick injury in 21 people (81%), conjunctival spray exposure in four (15%), and spray exposure of an open wound in one (4%) individual. At least one systemic symptom was reported in 19 (73%) people, including three (12%) who reported persistent local reactions with systemic involvement. One case required surgery, and B. abortus strain RB51 was isolated from the wound of that individual. Seven cases reported no adverse event associated with accidental exposure. Nine cases reported previous exposure to Brucella vaccines, including one case who also reported a previous diagnosis of brucellosis following exposure to S19 vaccine. Accidental needle stick injuries and conjunctival or open wound exposures of humans with the RB51 vaccine are associated with both local and systemic adverse events in the United States that are consistent with brucellosis; however, it remains undetermined if strain RB51 vaccine can cause systemic brucellosis in humans. Early culture attempts on those exposed and

  17. Outcome of Accidental Exposure Prone to Blood Borne Viral Infections in an Educational Hospital

    Shahnaz Sali; Shabnam Tehrani; Sara Abulghasemi

    2016-01-01

    Background: The risk for transmission of blood-borne viruses (BBVs) such as Human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) due to occupational exposure is a major concern in the health care setting.Materials and Methods: This study among 337 health care workers (HCWs) accidentally exposed to BBVs was carried out from January 2009 to March 2015. The data were reviewed in labbafinejhad hospital, Tehran, Iran.Results: 4 HCWs had exposure to HBS Ag positiv...

  18. Acute radiation syndrome caused by accidental radiation exposure - therapeutic principles

    Dörr Harald

    2011-11-01

    Full Text Available Abstract Fortunately radiation accidents are infrequent occurrences, but since they have the potential of large scale events like the nuclear accidents of Chernobyl and Fukushima, preparatory planning of the medical management of radiation accident victims is very important. Radiation accidents can result in different types of radiation exposure for which the diagnostic and therapeutic measures, as well as the outcomes, differ. The clinical course of acute radiation syndrome depends on the absorbed radiation dose and its distribution. Multi-organ-involvement and multi-organ-failure need be taken into account. The most vulnerable organ system to radiation exposure is the hematopoietic system. In addition to hematopoietic syndrome, radiation induced damage to the skin plays an important role in diagnostics and the treatment of radiation accident victims. The most important therapeutic principles with special reference to hematopoietic syndrome and cutaneous radiation syndrome are reviewed.

  19. Acute radiation syndrome caused by accidental radiation exposure - therapeutic principles

    Dörr Harald; Meineke Viktor

    2011-01-01

    Abstract Fortunately radiation accidents are infrequent occurrences, but since they have the potential of large scale events like the nuclear accidents of Chernobyl and Fukushima, preparatory planning of the medical management of radiation accident victims is very important. Radiation accidents can result in different types of radiation exposure for which the diagnostic and therapeutic measures, as well as the outcomes, differ. The clinical course of acute radiation syndrome depends on the ab...

  20. Evaluation of health effects in Sequoyah Fuels Corporation workers from accidental exposure to uranium hexafluoride

    Urine bioassay measurements for uranium and medical laboratory results were studied to determine whether there were any health effects from uranium intake among a group of 31 workers exposed to uranium hexafluoride (UF6) and hydrolysis products following the accidental rupture of a 14-ton shipping cylinder in early 1986 at the Sequoyah Fuels Corporation uranium conversion facility in Gore, Oklahoma. Physiological indicators studied to detect kidney tissue damage included tests for urinary protein, casts and cells, blood, specific gravity, and urine pH, blood urea nitrogen, and blood creatinine. We concluded after reviewing two years of follow-up medical data that none of the 31 workers sustained any observable health effects from exposure to uranium. The early excretion of uranium in urine showed more rapid systemic uptake of uranium from the lung than is assumed using the International Commission on Radiological Protection (ICRP) Publication 30 and Publication 54 models. The urinary excretion data from these workers were used to develop an improved systemic recycling model for inhaled soluble uranium. We estimated initial intakes, clearance rates, kidney burdens, and resulting radiation doses to lungs, kidneys, and bone surfaces. 38 refs., 10 figs., 7 tabs

  1. Oxycodone intoxication in an infant: accidental or intentional exposure?

    Levine, Barry; Moore, Karla A; Aronica-Pollak, Patricia; Fowler, David F

    2004-11-01

    A case is presented of a 10 month old male who went into cardiac arrest at a local store. The infant subsequently expired and was autopsied at the Office of the Chief Medical Examiner, State of Maryland. The only remarkable finding was the detection of oxycodone in the postmortem specimens; the blood and liver oxycodone concentrations were 0.6 mg/L and 1.6 mg/kg, respectively. Oxycodone was identified and quantitated by gas chromatography-nitrogen-phosphorus detection and confirmed by full scan electron ionization gas chromatography-mass spectrometry. The medical examiner ruled that the cause of death was oxycodone intoxication, and the manner of death was homicide. The key toxicologic question in this case was whether or not it was reasonable for the infant to be exposed to oxycodone exclusively through breast milk or through an alternate source. It was concluded that, at best, there were serious concerns about the likelihood of drug exposure through consumption of breast milk. PMID:15568714

  2. Use of ubiquitous materials for the estimation of accidental exposures

    Incidents involving unexpected radiation exposure do take place due to human error, equipment failure or other reasons in spite of regulatory systems being in place. Medical physicists who are also radiation safety officers (RSO) of their institutions in several countries, like India, have the responsibility of radiation protection of the staff, carers and comforters of the patients, visitors and public at large, apart from ensuring patient-specific treatment planning for accurate dose delivery, adoption of optimized practices, and minimization of chances of radiation accidents in radiation therapy, radio-diagnostic, and nuclear medicine practices. Theft and mishandling of 137Cs teletherapy source in 1987 in Goiania (Brazil) in which 28 people suffered radiation burns and five people (three men, one woman, and one child) died and several other incidents demonstrated that mishandling of a source from a place like hospital cannot be ruled out. In the recent times, especially after terrorist attack on World Trade Center, New York, USA (on September 11, 2001), apprehensions of radiation terrorism and other malevolent uses (Dirty Bomb) of radioactive materials have considerably increased all over the world. To meet the situation of any radiation accident (due to external sources or the hospital-based sources), preparedness for dosimetry of the exposed persons in the quickest possible way becomes important for the implementation of the necessary follow-up procedures

  3. Monobath Films for Determining Accidental High-Level Exposures

    For remote reactor plants and others not provided with a permanent monitoring team to measure the dose to the personnel, the monobath method is recommended for handling film dosimeters. With this method it is possible to determine on the spot and without any loss of time whether persons have received a critical dose calling for medical care. The films recommended enable doses from about 10 to 2000 r to be detected by subjecting the films to an extremely simple monobath process. The density curves, their dependence on the radiation energy and on the temperature of the monobath developer are shown. The films are processed in daylight in a small device the size of a cigarette packet. By means of this device, which is described in detail, 40 film dosimeters can be processed and evaluated by one person in about one hour. The dose is determined by comparing the film blackening with that of a strip fitted into the device for this purpose. The monobath films are conveniently worn in small sturdy film badges which are insensitive to external influences. Film evaluation is made only if the exposure to radiation is likely to have caused a substantial personnel dose. The films have a lifetime of at least two years. The badges contain a lead filter rendering the film blackening largely independent of the radiation energy over the range from about 75 keV up to 3 MeV and more. If desired, the lead filter can be provided with a window so that part of the radiation can reach the film unattenuated. In this way it is possible to draw conclusions as to the type (gamma or beta rays) and energy of the radiation, both essential factors for a correct evaluation of the hazards. The described monobath film dosimeters can be used alone in the event of an incident or together with other film dosimeters of high sensitivity or with pocket dosimeters based on ionization under normal monitoring conditions. (author)

  4. The risk of accidental incorporation of radioactive substances in medicine and scientific laboratories: Reports, hypothetical situations, emergency measures and precautions

    Accidental incorporations of radioactive substances in medicine and scientific laboratories are possible by inhalation, ingestion, percutaneous resorption and wound contamination. They may involve staff and/or patients. In the staff of laboratories, incorporations by inhalation of I-125 activities up to 7,4 kBq (200 nCi) have been reported for the personnel occupied with iodine labelling. On the contrary, no incorporations were found in labs using ready for use RIA kits. In nuclear medicine, incorporations by inhalation of I-131 activities up to 18,5 kBq (500 nCi) have been reported in the staff of radioiodine therapy units. Sufficient change of room air or the use of ventilation hoods prevents accidental inhalation of radioiodine. In contrast to those relatively unimportant risks, some cases of lethal incorporations by misadministration of radioactive substances to patients have been reported from nuclear medicine. They were caused by mix up or false calibration of therapeutic activities. For routine diagnostic procedures in nuclear medicine, extremely conservative risk estimations are given under the assumption that the complete stock of a radiopharmaceutical would have been mis-administered to a single patient. The radiation exposure of critical organs remains limited with an estimated maximum of 4 Gy (400 rad). Only after misadministration of I-131-NaI organ doses up to 10 Gy (1000 rad) may be imaginable. However, this accidental radiation exposure may be reduced by the proposed decorporation procedures. Obviously, such a misadministration must be prevented primarily by appropriate precautions which are discussed as well. (orig.)

  5. Accidental phosgene gas exposure: A review with background study of 10 cases

    Arvind Kumar Vaish

    2013-01-01

    Full Text Available Here, authors present a review on clinical presentation and management of exposure of phosgene gas after reviewing the literature by searching with keywords phosgene exposure on Google, Cochrane, Embase and PubMed with a background of experience gained from 10 patients who were admitted to our institute after an accidental phosgene exposure in February 2011 nearby a city in India. Phosgene is a highly toxic gas, occupational workers may have accidental exposure. The gas can also be generated inadvertently during fire involving plastics and other chemicals and solvents containing chlorine, which is of concern to emergency responders. Phosgene inhalation may cause initially symptoms of respiratory tract irritation, patients feel fine thereafter, and then die of choking a day later because of build up of fluid in the lungs (delayed onset non-cardiogenic pulmonary edema. Phosgene exposure is associated with significant morbidity and mortality. Patients with a history of exposure should be admitted to the hospital for a minimum of 24 h for observation because of the potential for delayed onset respiratory failure and acute respiratory distress syndrome.

  6. Accidental internal exposure of all groups of Chernobyl nuclear power plant employees

    Accidental internal exposure of Chernobyl NPP employees has started from April, 1986 and it was found to be decreased to pre-accident level at the end of 1987. Significant number of people from all groups of staff and temporary employees were measured using whole body counters situated in Clinical Department of the Institute of Biophysics, which has represented the main body for medical assistance and expertise in these people including those, who suffered from acute radiation syndrome as well as the people engaged in all kinds of works at Chernobyl NPP site. Technical characteristics of the equipment and techniques used to assess the internal exposure are given. (author)

  7. Retinal photoreceptor focal disruption secondary to accidental Nd:YAG laser exposure.

    Milani, Paolo; Pierro, Luisa; Pece, Alfredo; Marino, Valerio; Scialdone, Antonio

    2011-10-01

    Retinal injuries caused by accidental laser exposure include retinal or vitreous hemorrhages, macular holes and edema. We describe the imaging of a bilateral macular lesion secondary to accidental Nd:YAG laser exposure. Observational case report. We performed color photography, fluorescein angiography and autofluorescence (AF) with a scanning laser ophthalmoscope, as well as time-domain and spectral-domain optical coherence tomography (OCT). After accidental exposure to a 1064 nm Nd:YAG laser, a patient experienced blurred vision in the left eye (LE) with visual acuity of 20/60. Color, fluorescein angiography and OCT imaging showed a retinal hemorrhage in the foveal area of the left eye and in the inferomacular region of the asymptomatic right eye. Steroid therapy was then administered, and 5 days later there was rapid improvement with progressive re-absorption of the hemorrhages and functional recovery. At 6 month follow-up, visual acuity was 20/20 in both eyes with unremarkable biomicroscopy, except for focal foveal retinal pigment epithelium (RPE) atrophy in the LE. In comparison to previous hemorrhages, OCT could visualize focal disruption of the photoreceptor IS/OS junction in both eyes. Due to different macular pigment distribution and lesion localization, 787 nm near-infrared AF depicted a small hypofluorescent spot in both eyes, whilst at 488 nm AF a black spot became evident in the right eye only. Despite the re-absorption of foveal hemorrhage and the functional recovery, AF and OCT imaging highlighted the persistence of small focal disruptions of the photoreceptor outer segments and RPE. PMID:22002418

  8. Chronic or accidental exposure of oysters to norovirus: is there any difference in contamination?

    Ventrone, Iole; Schaeffer, Julien; Ollivier, Joanna; Parnaudeau, Sylvain; Pepe, Tiziana; Le Pendu, Jacques; Le Guyader, Françoise S

    2013-03-01

    Bivalve molluscan shellfish such as oysters may be contaminated by human pathogens. Currently, the primary pathogens associated with shellfish-related outbreaks are noroviruses. This study was conducted to improve understanding of oyster bioaccumulation when oysters were exposed to daily contamination or one accidental contamination event, i.e., different modes of contamination. Oysters were contaminated with two representative strains of norovirus (GI.1 and GII.3) and then analyzed with real-time reverse transcription PCR. Exposure to a repeated virus dose for 9 days (mimicking a growing area subjected to frequent sewage contamination) led to an additive accumulation that was not significantly different from that obtained when the same total dose of virus was added all at once (as may happen after accidental sewage discharge). Similarly, bioaccumulation tests performed with mixed strains revealed additive accumulation of both viruses. Depuration may not be efficient for eliminating viruses; therefore, to prevent contaminated shellfish from being put onto the market, continuous sanitary monitoring must be considered. All climatic events or sewage failures occurring in production areas must be recorded, because repeated low-dose exposure or abrupt events may lead to similar levels of accumulation. This study contributes to an understanding of norovirus accumulation in oysters and provides suggestions for risk management strategies. PMID:23462089

  9. Multiple-Purpose Personal Dosimeter Suitable for Dosimetry of High Accidental Exposures

    The paper describes the personal dosimeter designed by the Commissariat à l'énergie atomique to permit evaluation of the doses received by workers liable to high accidental exposures. It consists of a film dosimeter plus a glass, threshold and activation detector pack. The film dosimeter consists of a case fitted with screens demarcating seven different areas of the film. The latter, which provides density measurements by reflection, consists of three emulsions of different sensitivities on a common base, so that a single development covers the dose range between 20 mr and 800 r. An NTA nuclear-emulsion, fast-neution dosimeter can be added. Two glass dosimeters of different characteristics are included to permit separate evaluation of gamma and thermal neutron radiation. The unit also possesses conventional threshold and activation detectors. (author)

  10. Medical documentation, bioanalytical evidence of an accidental human exposure to sulfur mustard and general therapy recommendations.

    Steinritz, Dirk; Striepling, Enno; Rudolf, Klaus-Dieter; Schröder-Kraft, Claudia; Püschel, Klaus; Hullard-Pulstinger, Andreas; Koller, Marianne; Thiermann, Horst; Gandor, Felix; Gawlik, Michael; John, Harald

    2016-02-26

    Sulfur mustard (SM) is a chemical warfare agent (CWA) that was first used in World War I and in several military conflicts afterwards. The threat by SM is still present even today due to remaining stockpiles, old and abandoned remainders all over the world as well as to its ease of synthesis. CWA are banned by the Chemical Weapons Convention (CWC) interdicting their development, production, transport, stockpiling and use and are subjected to controlled destruction. The present case report describes an accidental exposure of three workers that occurred during the destruction of SM. All exposed workers presented a characteristic SM-related clinical picture that started about 4h after exposure with erythema and feeling of tension of the skin at the upper part of the body. Later on, superficial blister and a burning phenomenon of the affected skin areas developed. Similar symptoms occurred in all three patients differing severity. One patient presented sustained skin affections at the gluteal region while another patient came up with affections of the axilla and genital region. Fortunately, full recovery was observed on day 56 after exposure except some little pigmentation changes that were evident even on day 154 in two of the patients. SM-exposure was verified for all three patients using bioanalytical GC MS and LC MS/MS based methods applied to urine and plasma. Urinary biotransformation products of the β-lyase pathway were detected until 5 days after poisoning whereas albumin-SM adducts could be found until day 29 underlining the beneficial role of adduct detection for post-exposure verification. In addition, we provide general recommendations for management and therapy in case of SM poisoning. PMID:26321678

  11. Accidental carbon monoxide poisoning presenting without a history of exposure: A case report

    Bennetto Luke

    2008-04-01

    Full Text Available Abstract Introduction Carbon monoxide poisoning is easy to diagnose when there is a history of exposure. When the exposure history is absent, or delayed, the diagnosis is more difficult and relies on recognising the importance of multi-system disease. We present a case of accidental carbon monoxide poisoning. Case presentation A middle-aged man, who lived alone in his mobile home was found by friends in a confused, incontinent state. Initial signs included respiratory failure, cardiac ischaemia, hypotension, encephalopathy and a rash, whilst subsequent features included rhabdomyolysis, renal failure, amnesia, dysarthria, parkinsonism, peripheral neuropathy, supranuclear gaze palsy and cerebral haemorrhage. Despite numerous investigations including magnetic resonance cerebral imaging, lumbar puncture, skin biopsy, muscle biopsy and electroencephalogram a diagnosis remained elusive. Several weeks after admission, diagnostic breakthrough was achieved when the gradual resolution of the patient's amnesia, encephalopathy and dysarthria allowed an accurate history to be taken for the first time. The patient's last recollection was turning on his gas heating for the first time since the spring. A gas heating engineer found the patient's gas boiler to be in a dangerous state of disrepair and it was immediately decommissioned. Conclusion This case highlights several important issues: the bewildering myriad of clinical features of carbon monoxide poisoning, the importance of making the diagnosis even at a late stage and preventing the patient's return to a potentially fatal toxic environment, and the paramount importance of the history in the diagnostic method.

  12. Determination of reduction in life expectancy from stochastic somatic fatalities after accidental radiation exposure

    In risk studies for plants of the nuclear industry usually the number of fatalities by radiation induced health effects are assessed. They are divided into 'early fatalities' (mortality by acute radiation syndrom) and 'late fatalities' (deaths due to leukemia and cancer). For the individuals as well as for the society as a whole both health effects are in principle of different significance because of the different times of death after irradiation. Risk assessments which give only the number of fatalities therefore show an uncomplete picture of the consequence because they do not consider the age of the individuals at the time of death. In this report the mathematical models for the computation of the individual and collective reduction of life expectancy from stochastic somatic effects after accidental releases of radioactivity are described. Computational results with regard to the age distribution of the population are presented for persons living during the nuclear accident and persons born afterwards. Thereby the exposure pathways, organs and nuclides ot the German Risk Study are treated separately. A raw estimation of the reduction in life expectancy due to the late fatalities calculated in this study is given. (orig.)

  13. Health safety planning for possible accidental exposures of workers and population in Italy

    Unforeseen radiation exposures may be caused by technical or human faults in the utilization of radioactive devices, namely radionuclide sources, as well as from the peaceful uses of nuclear energy; the first instance is in general the more common one. The paper discusses the principal basis for health intervention planning in the case of possible accidental exposures of workers and/or the population to ionizing radiation, also with reference to hypothetical accidents at nuclear power stations. For this last purpose an important aspect is the definition of the 'source term' problem. The main differences existing between 'conventional' and radiation emergencies in the pre-planning of technical and health safety operations are discussed. Even if the general organizational planning is based on similar operating structures, radiation emergencies require a somewhat different approach. Besides the specialized aspects of prophylaxis and therapy which are needed in these cases, radiation emergencies call for a comparison of the social cost, the possible health detriment induced by health-related countermeasures and the specific radiation risk in a single case. In many instances, furthermore, a key role may also be played by psychological factors. Following this philosophy, a flexible organization plan has been drawn up, which consists of three-steps as follows: (1) local and/or regional level; (2) national level; (3) European or international level. For the first two levels, besides the possibility of utilizing health services, there is provision to arrange them into structures of increasing complexity, using modular, integrated and fixed operative units to adapt the intervention to specific aspects of each accident or emergency. The third level is represented by the WHO International Centre of Radiopathology (ICR) in Paris. An official agreement was recently signed by the ENEA and the Centre. (author)

  14. Maximum permissible amounts of accidentally released tritium derived from an environmental experiment to meet dose limits for public exposure

    This paper reports that it is important in the design of future fusion reactors and associated facilities that incorporate passive safety to take account of the possible environmental impact of accidental tritium release. Reliable information on dose consequences can be obtained by evaluating urine samples from persons exposed to tritium. Translating the results of the environmental HT experiment performed in France in 1986 into worst-case exposure conditions, the effective dose equivalent to an individual with highest exposure at a distance of 800 m (typical for site boundaries) is ∼1 x 10-4 Sv per gram of tritium emitted as HT when inhalation and skin absorption are considered. From this value, maximum permissible amounts of accidentally released HT can be derived on the basis of regulatory or anticipated dose limits

  15. Biological dose estimation for accidental supra-high dose gamma-ray exposure

    Chen, Y., E-mail: yingchen29@yahoo.com.cn [Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing 100850 (China); Yan, X.K. [Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing 100850 (China); Department of Radiation Safety, Beijing Institute of Nuclear and Chemical Safety, 14 Guan-cun, Dongcheng District, Beijing 100077 (China); Du, J.; Wang, Z.D.; Zhang, X.Q.; Zeng, F.G.; Zhou, P.K. [Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing 100850 (China)

    2011-09-15

    To correctly estimate the biological dose of victims accidentally exposed to a very high dose of {sup 60}Co gamma-ray, a new dose-effect curve of chromosomal dicentrics/multicentrics and rings in the supra-high dose range was established. Peripheral blood from two healthy men was irradiated in vitro with doses of {sup 60}Co gamma-rays ranging from 6 to 22 Gy at a dose rate of 2.0 Gy/min. Lymphocytes were concentrated, cultured and harvested at 52 h, 68 h and 72 h. The numbers of dic + r were counted. The dose-effect curves were established and validated using comparisons with doses from the Tokai-mura accident and were then applied to two victims of supra-high dose exposure accident. The results indicated that there were no significant differences in chromosome aberration frequency among the different culture times from 52 h to 72 h. The 6-22 Gy dose-effect curve was fitted to a linear quadratic model Y = -2.269 + 0.776D - 7.868 x l0{sup -3}D{sup 2}. Using this mathematic model, the dose estimates were similar to data from Tokai-mura which were estimated by PCC ring. Whole body average doses of 9.7 Gy and 18.1 Gy for two victims in the Jining accident were satisfactorily given. We established and successfully applied a new dose-effect curve of chromosomal dicentrics plus ring (dic + r) after 6-22 Gy {gamma}-irradiation from a supra-high dose {sup 60}Co gamma-ray accident.

  16. Estimation of high radiation dose during accidental exposure using Calyculin - an induced premature chromosome condensation assay

    The conventional cytogenetic dosimetry, the gold standard chromosomal aberration assay fails to estimate high radiation dose exposure due to mitotic delay and severe leukopenia. Hence, there is a need to establish reliable, easier and quicker methods for biodosimetry. The Calyculin-A induced premature chromosome condensation (PCC) assay is being recommended as a rapid method for biodosimetry. The calyculin-A is a strong inhibitor of both PP1 and PP2A phosphoprotein phosphatases and therefore, has been suggested to be a more potent inducer of PCC compared to other protein phosphatases inhibitor okadaic acid and fostriecin. In the present study, we have estimated coefficients of dose response curves for three PCC aberrations using Calyculin-A for biodosimetry purpose. The modified method outlined by Roser Puig et al 2013 was used to conduct Calyculin-A induced PCC assay in human blood lymphocytes. Calyculin A treatment was given for last 1 hr of the 48 hr culture. Final concentration of the Calyculin A was 50 nM and the study was carried out in the dose range 2.5-20 Gy using 60Co gamma rays. The centric rings, acentric rings and fragments are separately analyzed. Results show a linear dose dependent increase with a slope of 0.047±0.001 Gy-1 (R2=0.99 and P<0.0001) for centric rings and 0.07±0.002 (R2=0.99 and P<0.0001) for centric rings combined with acentric rings. The dose response of excess PCC fragments shows a linear quadratic response up to 15 Gy and thereafter it saturated. The linear and quadratic coefficients for fragments are 0.089 ± 0.04 Gy-1 and 0.0173 ± 0.003 Gy-2 (with R2=0.99 and P=3.5184E-4) respectively. The PCC index was 62% for 0 Gy, 56% for 2.5 Gy, 69% for 5 Gy, 73% for 7.5 Gy, 64% for 10 Gy, 55% for 15 Gy and 43% for 20 Gy. Results indicate that Calyculin-A induced PCC assay provides very high PCC index compared to okadaic acid and gives valuable biodosimetric information in the case of high dose accidental exposure. (author)

  17. DIFFICULTY IN BREATHING DUE TO ACCIDENTAL EXPOSURE TO HYPOCHLORITE SOLUTION IN ENDODONTIC TREATMENTREATHING DUE TO ACCIDENTAL EXPOSURE TO HYPOCHLORITE SOLUTION IN ENDODONTIC TREATMENT

    Buddiwati Punta

    2006-04-01

    Full Text Available An important phase of endodontic treatment is the irrigation of the root canal system. Desirable functions of irrigation are antimicrobial activity, dissolution of necrotic tissue, and non toxicity to the periradicular tissue. Toxicity of NaOCl solution on vital tissue is still controversial. Severe complications may occur if this solution is inadvertently exposed to the oral mucosa, and it is very hazardous. The purpose of this paper is to caution dentists on the hazards of using NaOCl irrigation in endodontic treatment. A case is presented in which 2.5% NaOCl solution was accidentally streaming into the patient's throat because the irrigating needle was not securely attached to the syringe, with the result that the patient had difficulty in breathing. The patient was promptly taken to a pulmonologist, internist, and ENT. The patient was given dexamethasone 10 mg iv injection, delladryl 1 cc iv, and nebulizer with 1 ampoule of steroid, 1 ampoule of ventolin and 5 cc NaCl 3x within 24 hours, and after 24 hours the condition was increased. From this case it is concluded that the 2.5% NaOCl solution is very alkaline and irritating, resulting in deem of the larynx and plugging up of the respiratory system. Clinicians need to be cautious in using NaOCl solution to avoid endangering the patient's life.

  18. Suggested Methods for Assessment of Accidental External Exposure and Internal Contamination of Workers and their Medical Management

    Certain assumptions are given for the amount of fission products released from a research reactor after the occurrence of an accident. The size and location of radioactive cloud are assumed, and the corresponding external and internal exposures of workers are computed. A method is suggested for assessment of accidental external radiation dose based on experimental studies performed on the changes of quenching effect of plasma or sera as a.result of whole- body gamma-radiation ranging from 25-200 rems. For assessment of accidentally internally incorporated gamma emitters we suggest the standard chair whole-body counter technique which was found to detect reliably 1/100 of the maximum permissible body burden within eight minutes. It was also suggested that a separation method based on the use of absorption phenomena observed for Sephadex (gel resin) can be applied for quick determination of gross alpha activity in urine. For management of accidentally exposed workers to radiation doses of a lethal or sublethal nature, bone-marrow transplantation therapy and blood component therapy in sterile rooms is discussed in the light of experience gained from treatment of leukaemia with intensive chemotherapy. (author)

  19. Laboratory exposure to Brucella melitensis in Denmark

    Knudsen, A; Kronborg, G; Knudsen, Inge Jenny Dahl;

    2013-01-01

    Disease Control and Prevention guidelines, but, of 14 staff members classified as high-risk exposure, none accepted post-exposure prophylaxis. However, in a period of 6 months of follow-up, none of the exposed laboratory workers developed brucellosis and all obtained sera were negative for antibrucella...

  20. Ferrofluid-associated Cutaneous Dyschromia: Discoloration of Hand and Fingers Following Accidental Exposure to Ferromagnetic Fluid

    Cohen, Philip R; Arfa, Kenneth S.

    2016-01-01

    Background: Ferrofluid is a colloidal suspension that usually consists of surfactant-coated nanoparticles of magnetite (Fe3O4) in a carrier liquid. Ferromagnetic fluid forms spikes when the liquid is exposed to a magnetic field. Purpose: The authors describe a man who developed temporary discoloration of his right palm and fingers after accidental cutaneous contact with ferrofluid and discuss some of the current and potential applications of this unique liquid. Methods: A 28-year-old man was ...

  1. Description of the SAFRAN Model for Evaluation of Public Exposure Resulting from Accidental Release of Airborne Radioactive Materials into the Atmosphere and User’s Guide. Annex II

    This document describes the method used in the SAFRAN tool for calculation of exposure arising from accidental release of airborne radioactive materials into the atmosphere. Model can be used for evaluation of public exposure to allow comparison with the relevant dose limiting criteria. The model is based on the public exposure evaluation concept as described in IAEA reports. While both these reports in primary addresses impacts arising from routine (e.g. long time permanent) releases, the concept employed can be adapted for assessment of impacts arising from accidental (e.g. short time) releases. Another source which has also been extensively used is the German Incident calculation bases

  2. Chromosome damage and clinical manifestation in a fetus and the mother after accidental 60Co exposure in Xinzhou

    The authors present the clinical effect and chromosome damage sustained by a fetus and the four months pregnant mother in an accidental 60Co exposure in November of 1992 in Xinzhou, Shanxi Province. The mother suffered from a moderate acute radiation sickness with ratardation of fetal development. After delivery, the infant's body length, body weight and head circumference were all lowered by three percentiles compared with the normals. Four months after the exposure, the assay of the mother's peripheral lymphocytes showed a chromosome aberration rate of 36%, while concomitant examination of the baby failed to reveal any chromosome abnormality although the sister chromatid exchange rate was remarkably higher than that of the mother and the normal control

  3. Pneumoconiosis and exposures of dental laboratory technicians

    One hundred and seventy-eight dental laboratory technicians and 69 non-exposed controls participated in an epidemiological respiratory study. Eight technicians who had a mean of 28 years grinding nonprecious metal alloys were diagnosed as having a simple pneumoconiosis by chest radiograph. Mean values for per cent predicted FVC and FEV1 were reduced among male nonsmoker technicians compared to male nonsmoker controls; after controlling for age, there was also a reduction in spirometry with increasing work-years. An industrial hygiene survey was conducted in 13 laboratories randomly selected from 42 laboratories stratified by size and type of operation in the Salt Lake City, Utah metropolitan area. Personal exposures to beryllium and cobalt exceeded the Threshold Limit Values (TLVs) in one laboratory. Occupational exposures in dental laboratories need to be controlled to prevent beryllium-related lung disorders as well as simple pneumoconiosis

  4. Electron paramagnetic resonance technique for radiation dosimetry: emerging trends for laboratory and accidental dosimetry

    The applications of Electron Paramagnetic Resonance (EPR) for radiation dosimetry are briefly reviewed. In particular, EPR-alanine dosimetry and accidental dosimetry using EPR signals from human tooth enamel have been discussed. The alanine dosimetry was found to be useful from low doses such as 1 Gy to high doses such as 100 kGy. The signals from tooth enamel are found to be invaluable in assessing the absorbed dose of people exposed to radiation accidents and also survivors of atomic bomb explosions. New emerging trends using EPR signals from bones exposed to radiation have also been briefly reviewed. (author)

  5. Urban "accidental" wetlands mediate water quality and heat exposure for homeless populations in a desert city

    Palta, M.

    2015-12-01

    In urban settings where humans interact in complex ways with ecosystems, there may be hidden or unanticipated benefits (services) or harm (disservices) conferred by the built environment. We examined interactions of a highly vulnerable population, the homeless, with urban waterways and wetlands in the desert city of Phoenix, Arizona, U.S.A. Climate change models project increases in heat, droughts, and extreme floods for the southwestern U.S. These projected changes pose a number of problems for sustainability and quality of future water supply, and the ability of human populations to mitigate heat stress and avoid fatalities. Urban wetlands that are created "accidentally" (by water pooling in abandoned areas of the landscape) have many structural (e.g., soils and hydrology) and functional (e.g., high denitrification) elements that mimic natural, unaltered aquatic systems. Accidental wetland systems in the dry bed of the Salt River, fed by storm and waste water from urban Phoenix, are located within economically depressed sections of the city, and show the potential for pollutant and heat mitigation. We used a mixed-method socio-ecological approach to examine wetland ecosystem functions and the ways in which homeless populations utilize Salt River wetlands for ecosystem services. Interviews and trash surveys indicated that homeless people are accessing and utilizing the wetlands as a source of running water, for sanitary and heat mitigation services, and for recreation and habitation. Environmental monitoring demonstrated that the wetlands can provide a reliable source of running water, nutrient and pathogen removal, heat mitigation, and privacy, but they may also pose a health risk to individuals coming in contact with the water through drinking or bathing. Whether wetlands provided a net benefit vs. harm varied according to site, season, and particular service, and several tradeoffs were identified. For example, heat is highest during the summer storm season

  6. Historical Doses To The Public from Routine and Accidental Releases of Tritium - Lawrence Livermore National Laboratory, 1953 - 2005

    Peterson, S; Raskob, W

    2007-08-15

    Throughout fifty-three years of operations, an estimated 29,300 TBq of tritium have been released to the atmosphere at the Livermore site of Lawrence Livermore National Laboratory; about 75% of this was released accidentally as gaseous tritium in 1965 and 1970. Routine emissions contributed slightly more than 3,700 TBq gaseous tritium and about 2,800 TBq tritiated water vapor to the total. Mean annual doses (with 95% confidence intervals) to the most exposed member of the public were calculated for all years using the same model and the same assumptions. Because time-dependent tritium models require detailed meteorological data that were unavailable for the large releases, ingestion/inhalation dose ratios were derived from experience with UFOTRI. Even with assumptions to assure that doses would not be underestimated, all doses from routine and accidental releases were below the level (3.6 mSv) at which adverse health effects have been documented, and most were below the current regulatory limit of 100 {micro}Sv per year from releases to the atmosphere.

  7. Automatic exposure system for radioactive source at teaching laboratory

    The development of Compton Scattering experiment, studied by undergraduate students of the Medical Physics course at the Universidade Estadual de Campinas (UNICAMP), takes place in the Medical Physics Teaching Laboratory, belonging to the Gleb Wataghin Physics Institute (IFGW/UNICAMP). The experiment consists of a fixed 137Cs radioactive source, with current activity of 610.5 MBq and a scintillation detector that turns around the center of the system whose function is to detect the scattered photons spectrum by a scatter object (target). The 137Cs source is stored in a lead shield with a collimating window for the gamma radiation emitted with energy of 0.662 MeV. This source is exposed only when an attenuation barrier protecting the collimating window is opened. The process of opening and closing the attenuation barrier may deliver a radiation dose to users when done manually. Considering the stochastic harmful effects of ionizing radiation, the goal of this project was to develop an automatic exposure system of the radioactive source, in order to reduce the radiation dose received during the Compton Scattering experiment. The developed system is micro controlled and performs standard operating routines, responding to emergencies. Furthermore, an electromagnetic lock enables quick closing of the barrier by gravity, in case of interruption of the electrical current circuit. Besides reducing the total dose to lab users, the system adds more security to the routine, since it limits the access to the radioactive source and prevents accidental exposure. (author)

  8. Historical Doses from Tritiated Water and Tritiated Hydrogen Gas Released to the Atmosphere from Lawrence Livermore National Laboratory (LLNL). Part 5. Accidental Releases

    Peterson, S

    2007-08-15

    Over the course of fifty-three years, LLNL had six acute releases of tritiated hydrogen gas (HT) and one acute release of tritiated water vapor (HTO) that were too large relative to the annual releases to be included as part of the annual releases from normal operations detailed in Parts 3 and 4 of the Tritium Dose Reconstruction (TDR). Sandia National Laboratories/California (SNL/CA) had one such release of HT and one of HTO. Doses to the maximally exposed individual (MEI) for these accidents have been modeled using an equation derived from the time-dependent tritium model, UFOTRI, and parameter values based on expert judgment. All of these acute releases are described in this report. Doses that could not have been exceeded from the large HT releases of 1965 and 1970 were calculated to be 43 {micro}Sv (4.3 mrem) and 120 {micro}Sv (12 mrem) to an adult, respectively. Two published sets of dose predictions for the accidental HT release in 1970 are compared with the dose predictions of this TDR. The highest predicted dose was for an acute release of HTO in 1954. For this release, the dose that could not have been exceeded was estimated to have been 2 mSv (200 mrem), although, because of the high uncertainty about the predictions, the likely dose may have been as low as 360 {micro}Sv (36 mrem) or less. The estimated maximum exposures from the accidental releases were such that no adverse health effects would be expected. Appendix A lists all accidents and large routine puff releases that have occurred at LLNL and SNL/CA between 1953 and 2005. Appendix B describes the processes unique to tritium that must be modeled after an acute release, some of the time-dependent tritium models being used today, and the results of tests of these models.

  9. Cross-sectional study on accidental occupational exposures amongst urban slum-based private medical practitioners

    Aniruddha A. Malgaonkar

    2015-12-01

    Full Text Available Background: This cross-sectional, complete enumeration study was conducted in an urban slum to determine the frequency of occupational exposure of private medical practitioners to patient body fluids and the remedial measures adopted following such events and also to examine their high-risk practices, personal protective measures, immunisation and training status in relation to occupational exposures. Methods: After Institutional Ethics Committee approval, private medical practitioners practising for and #8805; 1 year in the locality who gave written informed consent were interviewed in their own clinics using a pre-tested formatted questionnaire. Results: Of the 108 respondents interviewed, the majority were non-allopathic, male practitioners. The speciality-wise and gender-wise differences in training in occupational exposure were not significant (p=0.135. Prior to disposal, 10.18% cut needles while 26.85% disinfected needles with 1% hypochlorite solution (p=0.0001. 50.93% never bent or recapped needles (p=0.0008. Only 19.44% regularly used gloves while examining patients (p=0.0039. 41.66% were completely unimmunised against Hepatitis B (p=0.004, while only one female non-allopathic practitioner (0.92% had taken complete immunisation against tetanus (p<0.05. Of the 7.41% respondents who had history of needle stick injuries, only one female non-allopathic practitioner had reported occupational exposure. Those unaware about the need for post-exposure prophylaxis for occupational exposure and that anti-retroviral therapy was part of post-exposure prophylaxis constituted 87.96% and 95.37%, respectively. Conclusions: Reporting of occupational exposure, complete immunisation against hepatitis B and tetanus and use of personal protection was inadequate. Specialised hands-on training ought to be an integral component of continuing medical education for private medical practitioners. [Int J Res Med Sci 2015; 3(12.000: 3708-3713

  10. The accidental exposure to ionizing radiations; L'exposition accidentelle aux rayonnements ionisants

    NONE

    2001-07-01

    This article is divided in three parts, the first one gives the radioactivity sources, the doses and the effects, the second part is devoted to the medical exposures, the third part concerns the accidents and the biological effects of an irradiation the different syndromes ( the acute whole-body irradiation syndrome, the localized irradiation syndrome, the inflammatory syndrome, hematopoietic syndrome,neuro-vascular syndrome) are detailed. (N.C.)

  11. Occupational radiation exposures in research laboratories

    Radioactive sources are widely used in many research activities at University centers. In particular, the activities concerning use of sealed form (57Co in Moessbauer application) and unsealed form (3H, 14C, 32P in radioisotope laboratories) are analyzed. The radiological impact of these materials and potential effective doses to researchers and members of the public were evaluated to show compliance with regulatory limits. A review of the procedures performed by researchers and technicians in the research laboratories with the relative dose evaluations is presented in different situations, including normal operations and emergency situations, for example the fire. A study of the possible exposure to radiation by workers, restricted groups of people, and public in general, as well as environmental releases, is presented. (authors)

  12. In vivo EPR dosimetry of accidental exposures to radiation: experimental results indicating the feasibility of practical use in human subjects

    Low frequency electron paramagnetic resonance (EPR) provides the potential advantage of making accurate and sensitive measurements of absorbed radiation dose in teeth in situ, i.e. without removing the teeth from the potential victim. The potential limiting factors for making such measurements are: (1) whether low frequency EPR is sufficiently sensitive to detect radiation-induced signal in human teeth; (2) whether sufficient sensitivity can be maintained under in vivo conditions. In this manuscript, we summarize results indicating that this approach is feasible. Using 1.2 GHz EPR spectroscopy, we found that the lower limit for these measurements in isolated human teeth is 0.2 Gy or lower. Measurements of radiation-induced EPR signals in the teeth of living rats were achieved with sufficient sensitivity to indicate that, when taking into consideration the larger mass of human teeth, similar measurements in human teeth in situ would provide sensitivity in the dose range for potential accidental exposures. We estimate that the current lower limit for detecting radiation doses in human teeth in situ (in vivo) is 0.5-1.0 Gy; this would be sufficient for determining if a person has been exposed to potentially life threatening doses of ionizing radiation. The limiting factor for sensitivity appears to be background signals rather than signal/noise, and there are feasible means to overcome this problem and further increase sensitivity. The additional instrumental developments required to make an effective in vivo EPR dosimetric spectrometer for the measurements in teeth in human subjects in situ, seem quite achievable

  13. Application of the Alkaline Comet Assay and the Analysis of Structural Chromosome Aberrations in Assessment of Genetic Damage After Accidental Exposure to Ionising Radiation

    Full text: Living with the effects of low-level ionising radiation is one of the normal hazards of life. However, the effects of lower doses may not show up for years after exposure and are due to various changes in DNA molecules and chromosomes. Radiation-induced mutations seem to be brought about by the deletion of small pieces of chromosomes during the process of chromosome breakage and repair. Since chromosome damage is most likely to happen in dividing cells, ionising radiation usually cause cancer in those parts of the body where cells are actively dividing. Ionising radiation kills rapidly dividing cells, blood lymphocytes among them. People are exposed to high doses of ionising radiation when radiation accidents occur. The cytogenetical consequences of accidental exposure to gamma-radiation (radiation dose 221 mSv) were investigated by using alkaline Comet assay and the analysis of structural chromosomal aberrations (CA). Blood samples were repeatedly collected during one-year period after the accident. By using the Comet assay immediately after accidental exposure a high level of DNA damage was recorded. Although this level was decreasing over a one-year period, it was still elevated compared to normal values of DNA damage for unexposed persons. Immediately after the accident prevalence of CA (dicentrics, acentrics) over chromatid aberrations was recorded. However, one year afterwards only a few chromatid breaks were recorded. Our results confirmed usefulness of the alkaline Comet assay as a simple and sensitive technique for the biomonitoring of DNA damages, especially in the cases of accidental exposure to ionising radiation. (author)

  14. Description of the SAFRAN Models for Evaluation of Worker Exposure Resulting from Accidental Release of Airborne Radioactive Materials snd User’s Guide. Annex I

    This document describes the method used in the SAFRAN tool for the calculation of exposure arising from accidental release of airborne radioactive materials. Models can be used for evaluation of occupational exposure to allow comparison with the relevant dose limiting criteria. Presently, four models are available to address different exposure conditions. The first three are ‘no dilution’ model, ‘gradual mixing’ model and ‘complete mixing’ model. The fourth combined ‘gradual mixing / complete mixing’ model is a combination of the two last models and allows the user to run subsequently the ‘gradual mixing and ‘complete mixing’ models. Each of the models are created using Ecolego. Each of the models is described and their practical use is explained

  15. Assessment of risks associated to ionizing radiations: lung cancers after domestic radon exposure and thyroid cancers after accidental exposure to radioactive iodines

    The aim of this work is to develop a critical analysis of quantitative risk assessment in the field of ionizing radiation and to provide new estimates of attributable risks for particular situations of environmental exposure to ionizing radiation. This work is based on knowledge about dose-response relationships and ionizing radiation exposure of the general population. The work focuses on two different situations that both present an important interest for public health: lung cancer associated with domestic radon exposures (natural situation) and thyroid cancer associated with the Chernobyl accident fallout (accidental situation). The assessment of lung cancer risk associated with domestic radon exposure considers 10 dose-response relationships resulting from miner cohorts and case-control studies in the general population. A critical review of available data on smoking habits has been performed and allowed to consider the interactions between radon and tobacco. The exposure data come from measurements campaigns carried out since the beginning of the 1980 by the Institute for Radiation protection and Nuclear Safety and the Health General Directory in France. The French lung cancer mortality data are provided by the I.N.S.E.R.M.. Estimates of the number of attributable cancers are carried out for the whole country, stratified by 8 large regions (Z.E.A.T.) and by 96 departments for the year 1999 allowing to perform a sensibility analysis according to the geographical level of calculation. Uncertainties associated to risk coefficients and exposures have been quantified and it's impact on risk estimates is calculated. The estimated number of deaths attributable to domestic radon exposure ranges from 543 (90% uncertainty interval (U.I.): 75-1,097) to 3,108 (90% U.I.: 2,996-3,221). The corresponding risk fractions range from 2.2% (90% U.I.: 0.3%-4.4%) to 12.4% (90% U.I.: 11.9%-12.8%). The assessment of thyroid cancer risk in the most exposed area of France due to the

  16. Personnel Dosimetry for Radiation Accidents. Proceedings of a Symposium on Personnel Dosimetry for Accidental High-Level Exposure to External and Internal Radiation

    Accidents involving the exposure of persons to high levels of radiation have been few in number and meticulous precautions are taken in an effort to maintain this good record. When, however, such an accident does occur, a timely estimate of the dose received can be of considerable help to the physician in deciding whether a particular person requires medical treatment, and in selecting the most appropriate treatment. Individual dosimetry provides the physical basis for relating the observed effects to those in other accident cases, to other human data, and to data from animal experiments, thus providing an important aid to rational treatment and to the accumulation of a meaningful body of knowledge on the subject. It is most important therefore that, where there is a possibility of receiving high-level exposure, methods of personnel dosimetry should be available that would provide the dosimetric information most useful to the physician. Provision of good personnel dosimetry for accidental high-level exposure is in many cases an essential part of emergency planning because the information provided may influence emergency and rescue operations, and can lead to improved accident preparedness. Accordingly, the International Atomic Energy Agency and the World Health Organization jointly organized the Symposium on Personnel Dosimetry for Accidental High-Level Exposure to External and Internal Radiation for the discussion of such methods and for a critical review of the procedures adopted in some of the radiation accidents that have already occurred. The meeting was attended by 179 participants from 34 countries and from five other international organizations. The papers presented and the ensuing discussions are published in these Proceedings. It is hoped that the Proceedings will be of help to those concerned with the organization and development of wide-range personnel monitoring systems, and with the interpretation of the results provided

  17. Review of medical findings in a Marshallese population twenty-six years after accidental exposure to radioactive fallout

    In March 1954, radioactive debris from a thermonuclear weapon test at Bikini Atoll deviated from predicted trajectories and contaminated several atolls in the northern Marshall Islands. As a result, 239 native inhabitants of these islands along with 28 American servicemen and 23 Japanese fishermen received variably severe exposures to diverse ionizing radiations. Fallout material consisted largely of mixed fission products with small amounts of neutron-induced radionuclides and minimal amounts of fissionable elements, producing a complex spectrum of electromagnetic and particulate radiation. Individuals were exposed to deeply penetrating, whole-body gamma irradiation, to internal radiation emitters assimilated either by inhalation or by ingestion of contaminated water and food, and to direct radiation from material accumulating on body surfaces. That accident initiated a cascade of events, medical, social and political, which continue in varying forms to this day. Most of these have been discussed in the open medical literature and in periodic reports issued by the medical team headquartered at Brookhaven National Laboratory. This report attempts to summarize some of the principal findings of medical significnce that have been observed during the subsequent 26 years with particular emphasis on the last six years

  18. Review of medical findings in a Marshallese population twenty-six years after accidental exposure to radioactive fallout

    Conard, R.A.; Paglia, D.E.; Larsen, P.R.

    1980-01-01

    In March 1954, radioactive debris from a thermonuclear weapon test at Bikini Atoll deviated from predicted trajectories and contaminated several atolls in the northern Marshall Islands. As a result, 239 native inhabitants of these islands along with 28 American servicemen and 23 Japanese fishermen received variably severe exposures to diverse ionizing radiations. Fallout material consisted largely of mixed fission products with small amounts of neutron-induced radionuclides and minimal amounts of fissionable elements, producing a complex spectrum of electromagnetic and particulate radiation. Individuals were exposed to deeply penetrating, whole-body gamma irradiation, to internal radiation emitters assimilated either by inhalation or by ingestion of contaminated water and food, and to direct radiation from material accumulating on body surfaces. That accident initiated a cascade of events, medical, social and political, which continue in varying forms to this day. Most of these have been discussed in the open medical literature and in periodic reports issued by the medical team headquartered at Brookhaven National Laboratory. This report attempts to summarize some of the principal findings of medical significnce that have been observed during the subsequent 26 years with particular emphasis on the last six years.

  19. Rapid assessment of accidental exposures (RACE) in environment using ultra-sensitive LiF:Mg,Cu,P (MCP-N) thermoluminescent detectors

    The main goal of this work is to demonstrate a concept and first results of a new system for Rapid Assessment of Accidental Exposures (RACE) which is based on a new generation of ultra sensitive thermoluminescent detectors LiF:Mg, Cu, P. The RACE system is envisaged to be able to monitor environmental radiation doses at a large number of locations within a few days. The RACE will further be able to work as a standard detector system for routine environmental monitoring, but the major innovation is its capability to perform a rapid, short-term (ca. 24-48 hours) in situ dose assessment in case of any type of nuclear accidents, radiocontamination of environment or restoration works. (author). 8 refs, 5 figs

  20. Accidental Innovation

    Austin, Robert D.; Devin, Lee; Sullivan, Erin E.

    2012-01-01

    Historical accounts of human achievement suggest that accidents can play an important role in innovation. In this paper, we seek to contribute to an understanding of how digital systems might support valuable unpredictability in innovation processes by examining how innovators who obtain value from...... they incorporate accidents into their deliberate processes and arranged surroundings. By comparing makers working in varied conditions, we identify specific factors (e.g., technologies, characteristics of technologies) that appear to support accidental innovation. We show that makers in certain specified...... conditions not only remain open to accident but also intentionally design their processes and surroundings to invite and exploit valuable accidents. Based on these findings, we offer advice for the design of digital systems to support innovation processes that can access valuable unpredictability....

  1. Accidental exposure to biological material in healthcare workers at a university hospital: Evaluation and follow-up of 404 cases.

    Gutierrez, Eliana Battaggia; Lopes, Marta Heloísa; Yasuda, Maria Aparecida Shikanai

    2005-01-01

    The care and follow-up provided to healthcare workers (HCWs) from a large teaching hospital who were exposed to biological material between 1 August 1998 and 31 January 2002 is described here. After exposure, the HCW is evaluated by a nurse and doctor in an emergency consultation and receives follow-up counselling. The collection of 10 ml of blood sample from each HCW and its source patient, when known, is made for immunoenzymatic testing for HIV, HBV and HCV. Evaluation and follow-up of 404 cases revealed that the exposures were concentrated in only a few areas of the hospital; 83% of the HCWs exposed were seen by a doctor responsible for the prophylaxis up to 3 h after exposure. Blood was involved in 76.7% (309) of the exposures. The patient source of the biological material was known in 80.7% (326) of the exposed individuals studied; 80 (24.5%) sources had serological evidence of infection with 1 or more agents: 16.2% were anti-HCV positive, 3.8% were HAgBs positive and 10.9% were anti-HIV positive. 67% (273) of the study population completed the proposed follow-up. No confirmed seroconversion occurred. In conclusion, the observed adherence to the follow-up was quite low, and measures to improve it must be taken. Surprisingly, no difference in adherence to the follow-up was observed among those exposed HCW at risk, i.e. those with an infected or unknown source patient. Analysis of post-exposure management revealed excess prescription of antiretroviral drugs, vaccine and immunoglobulin. Infection by HCV is the most important risk of concern, in our hospital, in accidents with biological material. PMID:15804666

  2. Current radiation exposure of man: a comparison between digital imaging and environmental, workplace and accidental radiation burden

    X-ray imaging in diagnostic radiology is recognized worldwide as an outstanding tool for the early recognition and prevention of diseases. The reverse side is that radiography contributes essentially to the exposure of the public. Mean effective doses, averaged over patients and non-patients, are reaching or exceeding the level of natural radiation. This is particularly the case when digital imaging techniques are utilized, such as CT, coronary angiography and interventional radiology. Individual effective doses for a patient may occur between several mSv and several hundred mSv by one examination or a series of examinations, while individual organ doses of a patient may reach equivalent doses even up to several Sv, such as for the skin. The purpose of this review is to provide information on effective dose levels occurring in diagnostic radiology as compared with individual effective doses achieved from environmental radiation, radiation at workplaces and after major radiation incidents. (author)

  3. Rapid assessment of accidental exposures (RACE) with MCP-N (LiF:Mg,Cu,P) detectors

    The system is based on a new generation of ultra-sensitive thermoluminescent dosemeters and is able to monitor environmental radiation doses at a large number of locations within few days and to perform rapid (24 - 48 hours) in situ dose assessment in the event of any nuclear or radiation accident. Technical specifications of the instrumentation and procedures of the system are given. The linearity of the detector response for doses within the range of 1 μGy to 1 Gy is better than 2%. All the detectors investigated demonstrated a good stability in long-term exposure. The detectors are fully comparable with active detectors in short-term and daily routine dose rate measurements. (M.D.)

  4. Radiative accidental matter

    Sierra, D Aristizabal; Wegman, D

    2016-01-01

    Accidental matter models are scenarios where the beyond-the-standard model physics preserves all the standard model accidental and approximate symmetries up to a cutoff scale related with lepton number violation. We study such scenarios assuming that the new physics plays an active role in neutrino mass generation, and show that this unavoidably leads to radiatively induced neutrino masses. We systematically classify all possible models and determine their viability by studying electroweak precision data, big bang nucleosynthesis and electroweak perturbativity, finding that the latter places the most stringent constraints on the mass spectra. These results allow the identification of minimal radiative accidental matter models for which perturbativity is lost at high scales. We calculate radiative charged-lepton flavor violating processes in these setups, and show that $\\mu\\to e \\gamma$ has a rate well within MEG sensitivity provided the lepton-number violating scale is at or below $10^6\\,$ GeV, a value (natur...

  5. Optimizing bone surveys performed for suspected non-accidental trauma with attention to maximizing diagnostic yield while minimizing radiation exposure: utility of pelvic and lateral radiographs

    Skeletal surveys for non-accidental trauma (NAT) include lateral spinal and pelvic views, which have a significant radiation dose. To determine whether pelvic and lateral spinal radiographs should routinely be performed during initial bone surveys for suspected NAT. The radiology database was queried for the period May 2005 to May 2011 using CPT codes for skeletal surveys for suspected NAT. Studies performed for skeletal dysplasia and follow-up surveys were excluded. Initial skeletal surveys were reviewed to identify fractures present, including those identified only on lateral spinal and/or pelvic radiographs. Clinical information and MR imaging was reviewed for the single patient with vertebral compression deformities. Of the 530 children, 223 (42.1%) had rib and extremity fractures suspicious for NAT. No fractures were identified solely on pelvic radiographs. Only one child (<0.2%) had vertebral compression deformities identified on a lateral spinal radiograph. This infant had rib and extremity fractures and was clinically paraplegic. MR imaging confirmed the vertebral body fractures. Since no fractures were identified solely on pelvic radiographs and on lateral spinal radiographs in children without evidence of NAT, nor in nearly all with evidence of NAT, inclusion of these views in the initial evaluation of children for suspected NAT may not be warranted. (orig.)

  6. Optimizing bone surveys performed for suspected non-accidental trauma with attention to maximizing diagnostic yield while minimizing radiation exposure: utility of pelvic and lateral radiographs

    Jha, Priyanka; Stein-Wexler, Rebecca; Seibert, Anthony; Wootton-Gorges, Sandra L. [University of California Davis Medical Center, Department of Radiology, Sacramento, CA (United States); Coulter, Kevin [University of California Davis Medical Center, Department of Pediatrics, Sacramento, CA (United States); Li, Chin-Shang [University of California Davis Medical Center, Division of Biostatistics, Department of Public Health Sciences, Sacramento, CA (United States)

    2013-06-15

    Skeletal surveys for non-accidental trauma (NAT) include lateral spinal and pelvic views, which have a significant radiation dose. To determine whether pelvic and lateral spinal radiographs should routinely be performed during initial bone surveys for suspected NAT. The radiology database was queried for the period May 2005 to May 2011 using CPT codes for skeletal surveys for suspected NAT. Studies performed for skeletal dysplasia and follow-up surveys were excluded. Initial skeletal surveys were reviewed to identify fractures present, including those identified only on lateral spinal and/or pelvic radiographs. Clinical information and MR imaging was reviewed for the single patient with vertebral compression deformities. Of the 530 children, 223 (42.1%) had rib and extremity fractures suspicious for NAT. No fractures were identified solely on pelvic radiographs. Only one child (<0.2%) had vertebral compression deformities identified on a lateral spinal radiograph. This infant had rib and extremity fractures and was clinically paraplegic. MR imaging confirmed the vertebral body fractures. Since no fractures were identified solely on pelvic radiographs and on lateral spinal radiographs in children without evidence of NAT, nor in nearly all with evidence of NAT, inclusion of these views in the initial evaluation of children for suspected NAT may not be warranted. (orig.)

  7. Medical status of Marshallese accidentally exposed to 1954 Bravo fallout radiation, January 1983-December 1984

    Adams, W.H.; Engle, J.R.; Harper, J.A.; Heotis, P.M.; Scott, W.A.

    1986-01-01

    March 1, 1984, was the 30th anniversary of the Bravo thermonuclear test that resulted in the accidental exposure of the populations of Rongelap and Utirik atolls to radioactive fallout. The chronicling of the medical events resulting from that exposure is continued in this report, which covers the period from January 1983 through December 1984. An updated listing of all relevant publications from the Medical Department Brookhaven National Laboratory, is presented in the Reference Section. Thirty years of observation continue to show no detectable increase in mortality in the exposed population as a result of that exposure. The survival curves of the high-exposure Rongelap group, the low-exposure Utirik population, and an unexposed group of Rongelap people matched by age and sex to the exposed Rongelap group in 1957 continue to be similar. 89 refs., 2 figs., 6 tabs.

  8. Medical status of Marshallese accidentally exposed to 1954 Bravo fallout radiation, January 1983-December 1984

    March 1, 1984, was the 30th anniversary of the Bravo thermonuclear test that resulted in the accidental exposure of the populations of Rongelap and Utirik atolls to radioactive fallout. The chronicling of the medical events resulting from that exposure is continued in this report, which covers the period from January 1983 through December 1984. An updated listing of all relevant publications from the Medical Department Brookhaven National Laboratory, is presented in the Reference Section. Thirty years of observation continue to show no detectable increase in mortality in the exposed population as a result of that exposure. The survival curves of the high-exposure Rongelap group, the low-exposure Utirik population, and an unexposed group of Rongelap people matched by age and sex to the exposed Rongelap group in 1957 continue to be similar. 89 refs., 2 figs., 6 tabs

  9. Radiative accidental matter

    Sierra, D. Aristizabal; Simoes, C.; Wegman, D.

    2016-07-01

    Accidental matter models are scenarios where the beyond-the-standard model physics preserves all the standard model accidental and approximate symmetries up to a cutoff scale related with lepton number violation. We study such scenarios assuming that the new physics plays an active role in neutrino mass generation, and show that this unavoidably leads to radiatively induced neutrino masses. We systematically classify all possible models and determine their viability by studying electroweak precision data, big bang nucleosynthesis and electroweak perturbativity, finding that the latter places the most stringent constraints on the mass spectra. These results allow the identification of minimal radiative accidental matter models for which perturbativity is lost at high scales. We calculate radiative charged-lepton flavor violating processes in these setups, and show that μ → eγ has a rate well within MEG sensitivity provided the lepton-number violating scale is at or below 5×105 GeV, a value (naturally) assured by the radiative suppression mechanism. Sizeable τ → μγ branching fractions within SuperKEKB sensitivity are possible for lower lepton-number breaking scales. We thus point out that these scenarios can be tested not only in direct searches but also in lepton flavor-violating experiments.

  10. Occupational exposure in Greek industrial radiography laboratories (1996-2003)

    More than 40 industrial radiography laboratories are operating in Greece using X-ray or gamma-ray sources and more than 250 workers occupationally exposed to ionising radiation in these facilities are monitored on a regular basis. This study presents the evolution of individual doses received by radiographers during the past years. The mean annual dose (MAD) of all workers as well as of exposed workers is estimated, and correlated to the types of laboratories and practices applied. The MAD of the exposed workers in industrial radiography is compared with the doses of workers in other specialties and with the doses of radiographers in other countries. Furthermore, the study attempts to propose dose constraints for the practices in industrial radiography, according to the BSS European directive and the relevant Greek radiation protection legislation. The proposed value was defined as the dose below which the annual doses of 75% of the exposed radiographers are expected to be included. (authors)

  11. Research progress in study of accidental hypothermia

    Yuan, Rui; Zhang, Zhi-cheng

    2016-01-01

    Accidental hypothermia refers to a state of lowering of core body temperature down to 35 ℃induced by drowning, burial in snow and prolonged exposure to cold environment, etc. Hypothermia may affect the cardiovascular system, respiratory system, digestive system, etc. The triad consisting "hypothermia, acidosis and coagulopathy" is an important factor accelerating the death of patients. Early, timely application of rewarming measures is regarded as the basic principle in treatment of hypotherm...

  12. Estimation of the radiation exposure resulting from accidental discharges of radionuclides from nuclear facilities into rivers considering the time dependency on relevant parameters

    This report deals with possible source terms as well as with the transport of radionuclides in rivers. An estimate is presented of the radionuclide concentrations of Sr-90 and Cs-137 in the river system due to supposed or estimated short- and long-term source terms. The results are described of validating calculations for determination of the concentrations of Co-60 in the suspended load and sediment media. Then the radiation exposure resulting from the various source terms as well as selected results are discussed. (orig.)

  13. Toxic exposure to ethylene dibromide and mercuric chloride: effects on laboratory-reared octopuses.

    Adams, P M; Hanlon, R T; Forsythe, J W

    1988-01-01

    The effects of acute and chronic exposure to either ethylene dibromide (EDB) or mercuric chloride (MC) were studied in laboratory-reared Octopus joubini, O. maya and O. bimaculoides. The advantages of using octopuses were that the responses were immediate, highly visible and sensitive. All species demonstrated signs of toxicity to acute and chronic exposure to EDB and to MC. A dosage-sensitive relationship for the loss and subsequent recovery of locomotor response and of chromatophore expansion was found for each species after acute exposure. For each species the LC50 for chronic exposure occurred within 12 hr at 100 mg/l for EDB and within 3 hr at 1,000 mg/l for MC. This study demonstrated the potential usefulness of laboratory-reared octopuses in evaluating the toxicity of marine environmental pollutants. PMID:3072470

  14. Assessment of the Durability of Marble Cladding by Laboratory Exposure compared to Natural Exposure

    Hansen, Kurt Kielsgaard; Leksø, Henrik; Grelk, Bent

    2003-01-01

    Marble exposed to temperature cycles at high relative humidity (RH) under laboratory conditions loose strength similar to loss of strength for the same marble exposed to natural climate. Two marble types from three different building facades in Copenhagen are studied. From each building a marble...... cladding panel exposed for the south facing natural climate during 29, 60 and 61 years, respectively, and a cladding panel of each of the marble types only exposed for indoor climate are cut in bars of size 30x30x300 mm. The bars from indoor are exposed to temperature cycles between 10 °C and 60 °C at...... nearly 100% RH and at nearly 0% RH. The strength of the natural exposed marble as well as the laboratory-exposed marble are measured as flexural strength under concentrated load using four-point loading. Analysis of the strength test show that it is possible to transfer test results for laboratory...

  15. Exposure of Laboratory Animal Care Workers to Airborne Mouse and Rat Allergens

    Glueck, Joshua T; Huneke, Richard B; Perez, Hernando; Burstyn, Igor

    2012-01-01

    Urine of rats and mice is the main source of allergenic proteins that can enter the respiratory tract of laboratory animal care workers. Little is known about the levels and determinants of these exposures in the United States. We investigated the relationship between activities in animal facilities and levels of personal exposure to allergen by collecting personal breathing zone dust samples from 7 caretakers during full workdays for 1 wk. Mice and rat urinary allergens in inhalable dust wer...

  16. Exposure to culturable and total microbiota in cultural heritage conservation laboratories

    Górny, Rafał L.; Aleksander S. Harkawy; Anna Ławniczek-Wałczyk; Joanna Karbowska-Berent; Agnieszka Wlazło; Anna Niesler; Małgorzata Gołofit-Szymczak; Marcin Cyprowski

    2016-01-01

    Objectives: To date, the scientific source materials usually focus on microbial contamination of the museum or library collections themselves, while the exposure of persons who professionally deal with this type of objects in cultural heritage conservation laboratories is ignored. Material and Methods: The study was carried out in 9 naturally ventilated conservation laboratories with no history of water damage. Viable (understood as culturable) bioaerosol stationary samples were collected in ...

  17. Strategy for the lowering and the assessment of exposure to nanoparticles at workspace - Case of study concerning the potential emission of nanoparticles of Lead in an epitaxy laboratory

    Artous, Sébastien; Zimmermann, Eric; Douissard, Paul-Antoine; Locatelli, Dominique; Motellier, Sylvie; Derrough, Samir

    2015-05-01

    The implementation in many products of manufactured nanoparticles is growing fast and raises new questions. For this purpose, the CEA - NanoSafety Platform is developing various research topics for health and safety, environment and nanoparticles exposure in professional activities. The containment optimisation for the exposition lowering, then the exposure assessment to nanoparticles is a strategy for safety improvement at workplace and workspace. The lowering step consists in an optimisation of dynamic and static containment at workplace and/or workspace. Generally, the exposure risk due to the presence of nanoparticles substances does not allow modifying the parameters of containment at workplace and/or workspace. Therefore, gaseous or nanoparticulate tracers are used to evaluate performances of containment. Using a tracer allows to modify safely the parameters of the dynamic containment (ventilation, flow, speed) and to study several configurations of static containment. Moreover, a tracer allows simulating accidental or incidental situation. As a result, a safety procedure can be written more easily in order to manage this type of situation. The step of measurement and characterization of aerosols can therefore be used to assess the exposition at workplace and workspace. The case of study, aim of this paper, concerns the potential emission of Lead nanoparticles at the exhaust of a furnace in an epitaxy laboratory. The use of Helium tracer to evaluate the performance of containment is firstly studied. Secondly, the exposure assessment is characterised in accordance with the French guide “recommendations for characterizing potential emissions and exposure to aerosols released from nanomaterials in workplace operations”. Thirdly the aerosols are sampled, on several places, using collection membranes to try to detect traces of Lead in air.

  18. Health care workers and AIDS: a differential study of beliefs and affects associated with accidental exposure to blood Profissionais de saúde e AIDS: um estudo diferencial sobre crenças e afetos associados à experiência de exposição acidental a material biológico potencialmente contaminado

    Maria Rosa Rodrigues Rissi; Alcyone Artioli Machado; Marco Antonio de Castro Figueiredo

    2005-01-01

    This study aimed to analyze affective and cognitive determinants of the professional work of individuals caring for patients with HIV/AIDS, in view of the risk and/or experience of accidental exposure to blood. We drew on the theoretical-methodological references of Fishbein & Ajzen and Maslow's theory. Fifty health care workers were evaluated using an attitudes questionnaire and a needs and motivations instrument. The research verified differences between answers by health care workers who h...

  19. Pacific Northwest Laboratory plan to maintain radiation exposure as low as reasonably achievable (ALARA)

    This document describes the radiation safety program at the Pacific Northwest Laboratory (PNL). The practices and administrative policies of this program support the principles of ALARA (to maintain radiation exposure as low as reasonably achievable). This document also describes a program to establish safety goals at PNL to help ensure that operations are conducted according to ALARA principles

  20. Experimental Bleaching of a Reef-Building Coral Using a Simplified Recirculating Laboratory Exposure System

    Determining stressor-response relationships in reef building corals is a critical need for researchers because of global declines in coral reef ecosystems. A simplified recirculating coral exposure system for laboratory testing of a diversity of species and morphologies of reef b...

  1. Radiation exposure rates and radionuclide concentrations in soil around the Argonne National Laboratory-West Site

    As part of the routine environmental monitoring program at the Idaho National Engineering Laboratory, exposure rates were measured around the Argonne National Laboratory-West Site in 1973, 1976, and 1980, and soil samples were collected in 1978. Elevated exposure rates were measured along the northern and western sides of the EBR-II facility, in a drainage ditch on the west side of the EBR-II facility, around the perimeter of the radioactive scrap and waste facility, and at the southwest corner of the TREAT facility. Exposure rates measured in the 1980 survey were all less than 30 μR/h. Overall results indicated that except for the drainage ditch, the operation of the nuclear facilities for the past 21 years has not produced any general contamination of the soil around the ANL-W Site

  2. Organism/Organic Exposure to Orbital Stresses (OOREOS) Satellite: Radiation Exposure in LEO and Supporting Laboratory Studies

    Mattioda, Andrew Lige; Cook, Amanda Marie; Quinn, Richard C.; Elsaesser, Andreas; Ehrenfreund, Pascale; Ricca,Alessandra; Jones, Nykola C.; Hoffman, Soren; Ricco,Antonio

    2014-01-01

    We will present the results from the exposure of the metalloporphyrin iron tetraphenylporphyrin chloride (FeTPPCI), anthraufin (C(sub 14)H(sub 8)(O sub 4) (Anth) and Isoviolanthrene (C(sub 34H sub 18) (IVA) to the outher space environment, measured in situ aboard the Organism/Organic Exposure to Orbital Stresses nanosatellite. The compounds were exposed for a period of 17 months (3700 hours of direct solar exposure) including broad-spectrum solar radiation (approx. 122 nm to the near infrared). The organic films are enclosed in hermetically sealed sample cells that contain one of four astrobiologically relevant microenvironments. Transmission spectra (200-1000 nm) were recorded for each film, at first daily and subsequently every 15 days, along with a solar spectrum and the dark response of the detector array. In addition to analysis via UV-Vis spectroscopy, the laboratory controls were also monitored via infrared and far-UV spectroscopy. The results presented will include the finding that the FeTPPCI and IVA organic films in contact with a humid headspace gas (0.8-2.3%) exhibit faster degradation times, upon irradiation, in comparison with identical films under dry headspaces gases, whereas the Anth thin film exhibited a higher degree of photostability. In the companion laboratory experiments, simulated solar exposure of FeTPI films in contact with either Ar or CO(sub -2):O(sub -2):Ar (10:0.01:1000) headspace gas results in growth of a band in the films infrared spectra at 1961 cm(sup 1). Our assignment of this new spectral feature and the corresponding rational will be presented. The relevance of O/OREOS findings to planetary science, biomarker research, and the photostability of organic materials in astrobiologically relevant environments will also be discussed.

  3. Chemical Exposure Assessment Program at Los Alamos National Laboratory: A risk based approach

    The University of California Contract And DOE Order 5480.10 require that Los Alamos National Laboratory (LANL) perform health hazard assessments/inventories of all employee workplaces. In response to this LANL has developed the Chemical Exposure Assessment Program. This program provides a systematic risk-based approach to anticipation, recognition, evaluation and control of chemical workplace exposures. Program implementation focuses resources on exposures with the highest risks for causing adverse health effects. Implementation guidance includes procedures for basic characterization, qualitative risk assessment, quantitative validation, and recommendations and reevaluation. Each component of the program is described. It is shown how a systematic method of assessment improves documentation, retrieval, and use of generated exposure information

  4. Health care workers and AIDS: a differential study of beliefs and affects associated with accidental exposure to blood Profissionais de saúde e AIDS: um estudo diferencial sobre crenças e afetos associados à experiência de exposição acidental a material biológico potencialmente contaminado

    Maria Rosa Rodrigues Rissi

    2005-02-01

    Full Text Available This study aimed to analyze affective and cognitive determinants of the professional work of individuals caring for patients with HIV/AIDS, in view of the risk and/or experience of accidental exposure to blood. We drew on the theoretical-methodological references of Fishbein & Ajzen and Maslow's theory. Fifty health care workers were evaluated using an attitudes questionnaire and a needs and motivations instrument. The research verified differences between answers by health care workers who had never suffered accidents and those who had already experienced accidental exposure to blood. Health care workers did their work activities motivated by the need for self-fulfillment and valued their own performance when they were able to meet the patients' emotional needs. Among health professionals who had never experienced accidental exposure to blood, the predominant beliefs was that patients feel remorse over having expose themselves to HIV. Accidental exposure to blood raises difficulties in personal life. Technical aspects are also associated with the possibility of accidental exposure to blood.O objetivo deste estudo foi analisar determinantes afetivos e cognitivos que influenciam o trabalho de profissionais que cuidam de pessoas vivendo com o HIV/ AIDS, frente ao risco ou experiência de exposição acidental a material biológico potencialmente contaminado (MBPC. Utilizou-se o referencial teórico metodológico de Fishbein-Ajzen e a teoria de Maslow, que propõe a hierarquia das necessidades humanas. Cinqüenta profissionais de saúde foram avaliados por meio de escalas de atitudes, e de um instrumento de avaliação de necessidades e motivações. Verificou-se a diferença entre as respostas de profissionais que nunca sofreram acidente e aqueles que já passaram pela experiência de acidente ocupacional. Os resultados indicam que os profissionais exercem suas atividades motivados pela necessidade de auto-realização e valorizam sua performance

  5. Accidental exposures in radiotherapy: an history

    Radiotherapy accidents are exceedingly rare. However, they may have major negative consequences: for health (and sometimes life) of victims as well as for the trust that patients put in radiotherapy and radiation oncolysis. Each accident must be pointed out, analysed and reported, in order to allow preventive actions, avoiding repetitive accidents. Through examples of majors accidents occurred all over the world in the last decades, affecting professionals, public or patients themselves, the necessity of transparency is demonstrated. The International Commission of Radiobiological Protection has drawn positive lessons from such accidents and insists on following recommendations: necessity of sufficient number and competent professionals, importance of continuous and initial education, information of professionals and, in general, a strict Quality Assurance program. It is clear that each radiotherapy center remains at risk for errors. It is essential to develop preventive procedures to avoid transformation of errors into accidents. In that context, complete and detailed description and reports of each anomaly or incident must be encouraged as it is done for sectors of aviation or nuclear industry. Radiation oncology must develop such a culture of transparency and of systematic report of all incident. (authors)

  6. Practical aspects of personal exposure monitoring in hospitals and research laboratories

    The practical aspects of personal exposure monitoring in hospitals and research laboratories are closely linked to the type of radiation source and methods used for diagnosis or therapy. Various sources emit X-rays, γ-photons, high energy electrons or beta particles. In external radiation therapy, sources are either sealed or electrically generated; in brachytherapy, they are sealed to be used in interstitial and intracavitary irradiation. A radiodiagnostic department applies X-rays in a variety of ways. In nuclear medicine and in research laboratories unsealed sources are to be used for intravenous injection and radioactive labelling. The personnal is thus exposed, to the risk of external exposure or both external and internal exposure. Additional survey procedures are needed in the following instances: 1) radiodiagnosis especially in the disciplines where X-rays are necessary for the follow-up of the intervention (orthopedics, vascular and interventional radiology); 2) brachytherapy where the handling of sources requires the monitoring of radiation exposure to the hands; 3) nuclear medicine where employees handling unsealed sources require additional survey of the hands as well. However, the highest risk is that of internal exposure following contamination. For this situation the legislation calls for a periodic radiotoxicological and/or whole-body counting. In practice, such monitoring carried out every 6 months is not always adapted to the circumstances

  7. Allegheny County Fatal Accidental Overdoses

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Fatal accidental overdose incidents in Allegheny County, denoting age, gender, race, drugs present, zip code of incident and zip code of residence. Zip code of...

  8. Experimental Bleaching of a Reef-Building Coral Using a Simplified Recirculating Laboratory Exposure System

    Mace G. Barron; Cheryl J. McGill; Lee A. Courtney; Marcovich, Dragoslav T

    2010-01-01

    Determining stressor-response relationships in reef building corals continues to be a critical research need due to global declines in coral reef ecosystems and projected declines for the future. A simplified recirculating coral exposure system was coupled to a solar simulator to allow laboratory testing of a diversity of species and morphologies of reef building corals under ecologically relevant conditions of temperature and solar radiation. Combinations of lamps and attenuating filters al...

  9. Steam oxidation of TP 347H FG. Laboratory exposures versus service conditions at the power plant

    Hansson, Anette N. [DONG Energy A/S, Copenhagen (Denmark); Montgomery, Melanie [DONG Energy A/S, Copenhagen (Denmark); Technical Univ. of Denmark, Lyngby (Denmark). Dept. of Mechanical Engineering; Vattenfall Heat Nordic, Copenhagen (Denmark)

    2010-07-01

    TP347H FG is often used as final superheater tubing at Danish Power Plants. The oxidation behaviour of TP347H FG in steam was investigated both in laboratory conditions and field conditions. Short time exposures (336 hours) were performed in the laboratory at 500, 600 and 700 C in gasses with 8 or 46% H{sub 2}O and varying oxygen partial pressures. The shortest exposure time at the power plant was 7720 h, the temperature varied between 500 and 650 C. Surprisingly, thicker oxide layers formed within the laboratory facility at 600 and 700 C than during the long time exposures at the power plant. This could not be explained by spallation. Double-layered oxides developed during oxidation. The outer layer consist of Fe-oxides and the inner oxide contained Fe and the remaining alloy elements. Investigations with scanning electron microscopy (SEM) revealed that the morphology of the inner oxide was different for the two types of exposures. However, investigation using transmission electron microscopy (TEM) showed that the inner oxide in both cases consisted of particles of Fe-Mn-Cr spinel embedded in a metallic Fe-Ni matrix in the bulk of the (former) alloy grains and Cr-rich oxide layer along the (former) alloy grain boundaries. The main difference between the layers formed at the two locations is that the Cr-rich oxide layer is thicker for the samples exposed at the power plant than that for the samples exposed at the laboratory conditions. Furthermore, the depth of Cr depletion in the alloy adjacent the oxide layer is greater for the samples exposed at the power plant compared to those exposed in the laboratory. The microstructure investigation suggests that the slower oxidation rate of TP347H FG at the power plant as compared to the laboratory is due to a larger reservoir of Cr for the samples exposed at the power plant probably combined with a higher mobility of Cr within the alloy. (orig.)

  10. Accidental inhalation of mercury vapour: respiratory and toxicologic consequences.

    Lien, D. C.; Todoruk, D. N.; Rajani, H. R.; Cook, D A; Herbert, F. A.

    1983-01-01

    Four adults, including a pregnant woman, and three children were admitted to hospital following accidental exposure to mercury vapour produced by heating mercury-gold amalgam. Initial symptoms and signs included a paroxysmal cough, dyspnea, chest pain, tachypnea, nausea, vomiting, fever and leukocytosis. Pulmonary function testing performed on the second day after exposure revealed air-flow obstruction and minor restrictive defects in three patients. The diffusing capacity of the lung for car...

  11. Quality assurance for radon exposure chambers at the National Air and Radiation Environmental Laboratory, Montgomery, Alabama

    The Office of Radiation and Indoor Air, U.S. Environmental Protection Agency (EPA), operates six radon exposure chambers in its two laboratories, the National Air and Radiation Environmental Laboratory (NAREL) in Montgomery, Alabama, and the Las Vegas Facility, Las Vegas, Nevada. These radon exposure chambers are used to calibrate and test portable radon measuring instruments, test commercial suppliers of radon measurement services through the Radon Measurement Proficiency Program, and expose passive measurement devices to known radon concentrations as part of a quality assurance plan for federal and state studies measuring indoor radon concentrations. Both laboratories participate in national and international intercomparisons for the measurement of radon and are presently working with the National Institute of Standards and Technology (NIST) to receive a certificate of traceability for radon measurements. NAREL has developed an estimate of the total error in its calibration of each chamber's continuous monitors as part of an internal quality assurance program. This paper discusses the continuous monitors and their calibration for the three chambers located in Montgomery, Alabama, as well as the results of the authors intercomparisons and total error analysis

  12. Quality assurance for radon exposure chambers at the National Air and Radiation Environmental Laboratory, Montgomery, Alabama

    Semler, M.O.; Sensintaffar, E.L. [National Air and Radiation Environmental Laboratory, Montgomery, AL (United States)

    1993-12-31

    The Office of Radiation and Indoor Air, U.S. Environmental Protection Agency (EPA), operates six radon exposure chambers in its two laboratories, the National Air and Radiation Environmental Laboratory (NAREL) in Montgomery, Alabama, and the Las Vegas Facility, Las Vegas, Nevada. These radon exposure chambers are used to calibrate and test portable radon measuring instruments, test commercial suppliers of radon measurement services through the Radon Measurement Proficiency Program, and expose passive measurement devices to known radon concentrations as part of a quality assurance plan for federal and state studies measuring indoor radon concentrations. Both laboratories participate in national and international intercomparisons for the measurement of radon and are presently working with the National Institute of Standards and Technology (NIST) to receive a certificate of traceability for radon measurements. NAREL has developed an estimate of the total error in its calibration of each chamber`s continuous monitors as part of an internal quality assurance program. This paper discusses the continuous monitors and their calibration for the three chambers located in Montgomery, Alabama, as well as the results of the authors intercomparisons and total error analysis.

  13. Establishment of exposure dose assessment laboratory in National Radiation Emergency Medical Center (NREMC)

    As unclear industry grown, 432 of the nuclear power plants are operating and 52 of NPPs are under construction currently. Increasing use of radiation or radioisotopes in the field of industry, medical purpose and research such as non-destructive examination, computed tomography and x-ray, etc. constantly. With use of nuclear or radiation has incidence possibility for example the Fukushima NPP incident, the Goiania accident and the Chernobyl Nuclear accident. Also the risk of terror by radioactive material such as Radiological Dispersal Device(RDD) etc. In Korea, since the 'Law on protection of nuclear facilities and countermeasure for radioactive preparedness was enacted in 2003, the Korean institute of Radiological and Medical Sciences(KIRAMS) was established for the radiation emergency medical response in radiological disaster due to nuclear accident, radioactive terror and so on. Especially National Radiation Emergency Medical Center(NREMC) has the duty that is protect citizens from nuclear, radiological accidents or radiological terrors through the emergency medical preparedness. The NREMC was established by the 39-article law on physical protection of nuclear material and facilities and measures for radiological emergencies. Dose assessment or contamination survey should be performed which provide the radiological information for medical response. For this reason, the NREMC establish and re-organized dose assessment system based on the existing dose assessment system of the NREMC recently. The exposure dose could be measured by physical and biological method. With these two methods, we can have conservative dose assessment result. Therefore the NREMC established the exposure dose assessment laboratory which was re-organized laboratory space and introduced specialized equipment for dose assessment. This paper will report the establishment and operation of exposure dose assessment laboratory for radiological emergency response and discuss how to enhance

  14. Laboratory Tests for Group and Individual Exposures of Arion lusitanicus Mabille Slugs to Different Molluscicide Baits

    Bojan Stojnić

    2008-01-01

    Full Text Available Molluscicide baits based on different active ingredients were tested in a seven-day laboratory trial on juveniles and young adults of Arion lusitanicus Mabille slug collected in ruderal sites during June and July of 2008. Before setting the trial, the slugs were adapted to laboratory conditions. The testing was conducted using a modified version of the method proposed by Godan (1983 and Wiktor (1989. The slugs were kept in arenas under controlled conditions (20-24oC temperature, 80-90% relative air humidity, no air stream, diffuse daylight. Smaller(15.5 x 15.5 x 7 cm and larger (28 x 17.5 x 7 cm arenas were used, depending on slug numbers, and different rates of food and bait were administered. Plastic boxes with perforated coverage, lined with multi-ply paper moistened on a daily basis, were used as arenas. The slugs were fed on fresh salad daily, while baits were administered in open 35 mm petri dishes once for the duration of experiment. The first trial involved single-slug exposures to bait in 20 arenas per each of four treatments with two replicates and a total of 160 slugs. The second trial, group exposure, involved four treatments of five slugs per arena in six replicates with a total of 120 slugs. The products Arion and Pužomor demonstrated the highest efficacy (77.5% in the single-slug trial. The average efficacy of the product Carakol after seven days of exposure was 60.0%. Regarding group exposure, Pužomor pellets achieved 79.3% efficacy after three days and this efficacy rate remained for the rest of the experiment. On the seventh day ofexposure, Arion and Carakol had 33.3% and 40.0% efficacy, respectively.

  15. Accidental degeneracies in string compactification

    Bais, F.A.; Taormina, A.

    1986-11-27

    The equivalence of the torus and group manifold compactification of strings is established. Accidental degeneracies are shown to occur for a large class of compactifications. This way many examples are obtained in which modular invariance does not uniquely fix the representation content of the spectrum.

  16. Accidental degeneracies in string compactification

    Bais, F. A.; Taormina, A.

    1986-11-01

    The equivalence of the torus and group manifold compactification of strings is established. Accidental degeneracies are shown to occur for a large class of compactifications. This way many examples are obtained in which modular invariance does not uniquely fix the representation content of the spectrum.

  17. Accidente de Trabajo y Recargo

    Pérez Alonso, María Antonia

    2015-01-01

    En la actualidad existen diferentes formas de Accidente de Trabajo. En el presente trabajo se da a conocer las distintas formas y la doctrina de los tribunales. Se aborda el recargo de prestaciones de Seguridad Social y el deber del empresario en cumplir la normativa de Seguridad Social

  18. Medical management of accidentally exposed individuals

    Bone marrow aplasia is one of the main syndromes following a high dose accidental radiation exposure. Although both transfusion and bone marrow transplantation have been used with some success since the first treatments of patients, other therapeutic strategies are needed. New promising approaches of the treatment of aplasia have appeared with the development of experimental and clinical hematology. Some new trends for the treatment of the hematopoietic injury based on bone marrow transplantation rely on new sources of compatible donor cells, such as cord blood, on the selection of immature haemopoietic cells and on new transplant regimens. The hematopoietic growth factors stimulate proliferation and/or differentiation of hematopoietic progenitors and possibly stem cells. Furthermore, they act on the functions of mature cells. They have now specific uses in hematology, related to their role in the regulation of growth and differentiation of hematopoietic progenitor cells. Some growth factors have already been used for the treatment of accidental radiation-induced aplasia and lessons have been learned from their medical management and follow-up. (author)

  19. Medical management of accidentally exposed individuals

    Bone marrow aplasia is one of the main syndromes following a high dose accidental radiation exposure. Whilst transfusion and bone marrow transplantation have been used with some success starting with the first treatments of accident victims, other therapeutic strategies are needed. With the development of experimental and clinical haematology, promising new approaches to the treatment of aplasia have appeared. New trends for the treatment of haemopoietic injury based on bone marrow transplantation rely on new sources of compatible donor cells, such as cord blood, on the selection of immature haemopoietic cells and on new transplant regimens. Haemopoietic growth factors stimulate the proliferation and/or differentiation of haemopoietic progenitors and, possibly, stem cells. Furthermore, they act on the functions of mature cells. Currently, they have specific uses in haematology related to their role in the regulation of growth and in the differentiation of haemopoietic progenitor cells. Growth factors have already been used for the treatment of accidental radiation induced aplasia and lessons have been learned from their medical management and followup. (author)

  20. Accidental radioisotope burns - Management of late sequelae

    Varghese Bipin

    2010-10-01

    Full Text Available Accidental radioisotope burns are rare. The major components of radiation injury are burns, interstitial pneumonitis, acute bone marrow suppression, acute renal failure and adult respiratory distress syndrome. Radiation burns, though localized in distribution, have systemic effects, and can be extremely difficult to heal, even after multiple surgeries. In a 25 year old male who sustained such trauma by accidental industrial exposure to Iridium192 the early presentation involved recurrent haematemesis, pancytopenia and bone marrow suppression. After three weeks he developed burns in contact areas in the left hand, left side of the chest, abdomen and right inguinal region. All except the inguinal wound healed spontaneously but the former became a non-healing ulcer. Pancytopenia and bone marrow depression followed. He was treated with morphine and NSAIDs, epidural buprinorphine and bupivicaine for pain relief, steroids, antibiotics followed by wound excision and reconstruction with tensor fascia lata(TFL flap. Patient had breakdown of abdominal scar later and it was excised with 0.5 cm margins up to the underlying muscle and the wound was covered by a latissimis dorsi flap. Further scar break down and recurrent ulcers occurred at different sites including left wrist, left thumb and right heel in the next two years which needed multiple surgical interventions.

  1. MDI Biological Laboratory Arsenic Summit: Approaches to Limiting Human Exposure to Arsenic.

    Stanton, Bruce A; Caldwell, Kathleen; Congdon, Clare Bates; Disney, Jane; Donahue, Maria; Ferguson, Elizabeth; Flemings, Elsie; Golden, Meredith; Guerinot, Mary Lou; Highman, Jay; James, Karen; Kim, Carol; Lantz, R Clark; Marvinney, Robert G; Mayer, Greg; Miller, David; Navas-Acien, Ana; Nordstrom, D Kirk; Postema, Sonia; Rardin, Laurie; Rosen, Barry; SenGupta, Arup; Shaw, Joseph; Stanton, Elizabeth; Susca, Paul

    2015-09-01

    This report is the outcome of the meeting "Environmental and Human Health Consequences of Arsenic" held at the MDI Biological Laboratory in Salisbury Cove, Maine, August 13-15, 2014. Human exposure to arsenic represents a significant health problem worldwide that requires immediate attention according to the World Health Organization (WHO). One billion people are exposed to arsenic in food, and more than 200 million people ingest arsenic via drinking water at concentrations greater than international standards. Although the US Environmental Protection Agency (EPA) has set a limit of 10 μg/L in public water supplies and the WHO has recommended an upper limit of 10 μg/L, recent studies indicate that these limits are not protective enough. In addition, there are currently few standards for arsenic in food. Those who participated in the Summit support citizens, scientists, policymakers, industry, and educators at the local, state, national, and international levels to (1) establish science-based evidence for setting standards at the local, state, national, and global levels for arsenic in water and food; (2) work with government agencies to set regulations for arsenic in water and food, to establish and strengthen non-regulatory programs, and to strengthen collaboration among government agencies, NGOs, academia, the private sector, industry, and others; (3) develop novel and cost-effective technologies for identification and reduction of exposure to arsenic in water; (4) develop novel and cost-effective approaches to reduce arsenic exposure in juice, rice, and other relevant foods; and (5) develop an Arsenic Education Plan to guide the development of science curricula as well as community outreach and education programs that serve to inform students and consumers about arsenic exposure and engage them in well water testing and development of remediation strategies. PMID:26231509

  2. Research progress in study of accidental hypothermia

    Rui YUAN

    2016-04-01

    Full Text Available Accidental hypothermia refers to a state of lowering of core body temperature down to 35 ℃induced by drowning, burial in snow and prolonged exposure to cold environment, etc. Hypothermia may affect the cardiovascular system, respiratory system, digestive system, etc. The triad consisting "hypothermia, acidosis and coagulopathy" is an important factor accelerating the death of patients. Early, timely application of rewarming measures is regarded as the basic principle in treatment of hypothermia. A series of rewarming measures, such as infusion of warm fluids, inspiration of warm air, abdominal infusion of warm fluid, instruction of warm fluid into pleural cavity, intravenous infusion of warm fluid, rewarming through ECMO, etc. have been used recently. Advance in research on the classification of hypothermia, its impact to the body and the treatment methods are reviewed in present paper. DOI: 10.11855/j.issn.0577-7402.2016.04.15

  3. Organizational influence on the occurrence of work accidents involving exposure to biological material La influencia de la organización en la ocurrencia de accidentes de trabajo con exposición a material biológico Influência organizacional na ocorrência de acidentes de trabalho com exposição a material biológico

    Maria Helena Palucci Marziale

    2013-02-01

    Full Text Available OBJECTIVES: to analyze work accidents involving exposure to biological materials which took place among personnel working in nursing and to evaluate the influence of the organizational culture on the occurrence of these accidents. METHOD: a retrospective, analytical study, carried out in two stages in a hospital that was part of the Network for the Prevention of Work Accidents. The first stage involved the analysis of the characteristics of the work accidents involving exposure to biological materials as recorded over a seven-year period by the nursing staff in the hospital studied, and registered in the Network databank. The second stage involved the analysis of 122 nursing staff members' perception of the institutional culture, who were allocated to the control group (workers who had not had an accident and the case group (workers who had had an accident. RESULTS: 386 accidents had been recorded: percutaneous lesions occurred in 79% of the cases, needles were the materials involved in 69.7% of the accidents, and in 81.9% of the accident there was contact with blood. Regarding the influence of the organizational culture on the occurrence of accidents, the results obtained through the analysis of the two groups did not demonstrate significant differences between the average scores attributed by the workers in each organizational value or practice category. It is concluded that accidents involving exposure to biological material need to be avoided, however, it was not possible to confirm the influence of organizational values or practices on workers' behavior concerning the occurrence of these accidents.OBJETIVOS: analizar los accidentes de trabajo con exposición a material biológico entre el personal de enfermería y evaluar la influencia de la cultura organizacional en la ocurrencia de accidentes de este tipo. MÉTODO: estudio retrospectivo, analítico, desarrollado en dos etapas en un Hospital de la Red para la Prevención de Accidentes. En

  4. Adesão a protocolo pós-exposição ocupacional de acidentes entre cirurgiões dentistas Adhesión a protocolo post exposición ocupacional de accidentes entre cirujanos dentistas Compliance with occupational post-exposure protocol for injuries among dental surgeons

    Andréa Maria Eleutério de Barros Lima Martins

    2010-06-01

    Full Text Available OBJETIVO: Analisar a adesão a protocolo pós-exposição ocupacional a acidentes e os fatores relacionados à adesão entre cirurgiões-dentistas. MÉTODOS: Estudo transversal realizado em Montes Claros, MG, de 2007 a 2008, com cirurgiões-dentistas em atividade clínica com relato de ocorrência de acidentes com instrumentos perfurocortantes no seu exercício profissional. As variáveis referentes à caracterização do dentista, condições de trabalho dos dentistas, caracterização da clientela atendida, características dos acidentes com instrumentos perfurocortantes sofridos pelos dentistas e condutas pós-acidentes foram avaliadas por meio de um questionário estruturado, previamente testado. Os dados foram submetidos à análise descritiva e ao teste qui-quadrado (p OBJETIVO: Analizar la adhesión a protocolo post exposición ocupacional a accidentes y los factores relacionados a la adhesión entre cirujanos dentistas. MÉTODOS: Estudio transversal realizado en Montes Claros, Sureste de Brasil, de 2007 a 2008, con cirujanos dentistas en actividad clínica con relato de ocurrencia de accidentes con instrumentos perfurocortantes en el ejercicio profesional. Las variables relacionadas con la caracterización del dentista, condiciones de trabajo de los dentistas, caracterización de la clientela atendida, características de los accidentes con instrumentos perfurocortantes sufridos por los dentistas y conductas post accidentes fueron evaluadas por medio de un cuestionario estructurado, previamente testado. Los datos fueron sometidos al análisis descriptivo y a la prueba de chi-cuadrado (pOBJECTIVE: To analyze the compliance with occupational post-exposure protocol for accidents and factors associated with compliance among dental surgeons. METHODS: A cross-sectional study was performed in the municipality of Montes Claros, Southeastern Brazil, from 2007 to 2008, with accident reports from needles and sharp instruments among practicing

  5. Accidental Turbulent Discharge Rate Estimation from Videos

    Ibarra, Eric; Shaffer, Franklin; Savaş, Ömer

    2015-11-01

    A technique to estimate the volumetric discharge rate in accidental oil releases using high speed video streams is described. The essence of the method is similar to PIV processing, however the cross correlation is carried out on the visible features of the efflux, which are usually turbulent, opaque and immiscible. The key step in the process is to perform a pixelwise time filtering on the video stream, in which the parameters are commensurate with the scales of the large eddies. The velocity field extracted from the shell of visible features is then used to construct an approximate velocity profile within the discharge. The technique has been tested on laboratory experiments using both water and oil jets at Re ~105 . The technique is accurate to 20%, which is sufficient for initial responders to deploy adequate resources for containment. The software package requires minimal user input and is intended for deployment on an ROV in the field. Supported by DOI via NETL.

  6. Ecotoxicological response of marine organisms to inorganic and organic sediment amendments in laboratory exposures.

    Rosen, Gunther; Leather, James; Kan, Jinjun; Arias-Thode, Yolanda Meriah

    2011-10-01

    Experimental materials currently being investigated for use as amendments for the in situ remediation of contaminated sediments were assessed for their potential impacts on marine benthos. Laboratory toxicity tests involving lethal and sublethal endpoints were conducted on sediments amended with apatite, organoclay, chitin, or acetate, with the polychaete Neanthes arenaceodentata, the amphipod Eohaustorius estuarius, and the larval sheepshead minnow Cyprinodon variegatus. Amendments were mixed loosely into uncontaminated or metal-contaminated sediments, and also added inside experimental geotextile mats, at sediment dry weight (dw) concentrations ranging from 0.5% to 10%. The geotextile mats, containing apatite (5 or 10% dw), and/or organoclay (5%) did not result in adverse effects on any of the test organisms. Chitin and acetate, however, repetitively resulted in adverse effects on survival and/or adverse or positive effects on organism growth at concentrations of ≤ 2.5% dw. The adverse effects were attributed to water quality degradation in the exposure vessels (notably ammonia and dissolved oxygen concentration, for chitin and acetate, respectively) as a result of the microbial breakdown of the amendments. For N. arenaceodentata, growth was enhanced in the presence of chitin at concentrations as low as 0.5% sediment dw, which stimulated bacterial growth that may have provided an additional food source for the polychaete. Sediment chitin concentrations of 0.5% resulted in a statistically significant reduction in N. arenaceodentata body burdens of 61%, 29%, and 54%, relative to unamended contaminated sediment, for Cu, Zn, and Cd, respectively. The studies suggest a lack of inherent toxicity of these materials on the experimental organisms, as the adverse or positive responses observed are likely related to artifacts associated with laboratory exposure. Assessments in field settings are needed to verify this conclusion. PMID:21840599

  7. Biochemical response of amphipods (Gammarid: Paramorea) in a sediment laboratory exposure from Ushuaia Bay, Beagle Channel.

    Schvezov, Natasha; Amin, Oscar

    2011-03-01

    A coastal system (Ushuaia Bay, Argentina) impacted by anthropogenic activities was studied by the response of local amphipods (Parmorea sp., Gammaridae) to the exposure of coastal sediments in a laboratory assay. Four coastal areas with different loadings of contaminants and one considered as reference were studied. Organic matter, carbohydrates, proteins and heavy metals were measured in sediment samples. Organisms were exposed to sediments for seven days and catalase (CAT), glutathione S-transferase (GST), acetylcholinesterase (AChE) and lipid peroxidation (LPO) were measured afterward. Amphipods exhibited an activation of GST and inhibition of AChE in most impacted areas. Principal Component Analysis (PCA) was conducted in order to associate the biological responses with sediment metal concentration and its eutrophicated status. Levels of Cd and Cr were associated with the inhibition of AChE and with the enhancement of GST. CAT and LPO were enhanced in most areas, but no link was found with the contaminants studied by PCA, suggesting that other parameters present in sediments not included in the PCA affect the amphipods. The most impacted area corresponds to Nautical Club station, with a highly eutrophicated status and high content of metals, where amphipods after the exposure were affected in a biochemical level. PMID:21239059

  8. Promoting early exposure monitoring for respirable crystalline silica: Taking the laboratory to the mine site.

    Cauda, Emanuele; Miller, Arthur; Drake, Pamela

    2016-01-01

    The exposure to respirable crystalline silica (RCS) in the mining industry is a recognized occupational hazard. The assessment and monitoring of the exposure to RCS is limited by two main factors: (1) variability of the silica percent in the mining dust and (2) lengthy off-site laboratory analysis of collected samples. The monitoring of respirable dust via traditional or real-time techniques is not adequate. A solution for on-site quantification of RCS in dust samples is being investigated by the Office of Mine Safety and Health Research, a division of the National Institute for Occupational Safety and Health. The use of portable Fourier transform infrared analyzers in conjunction with a direct-on-filter analysis approach is proposed. The progress made so far, the necessary steps in progress, and the application of the monitoring solution to a small data set is presented. When developed, the solution will allow operators to estimate RCS immediately after sampling, resulting in timelier monitoring of RCS for self-assessment of compliance at the end of the shift, more effective engineering monitoring, and better evaluation of control technologies. PMID:26558490

  9. Rock Formation and Cosmic Radiation Exposure Ages in Gale Crater Mudstones from the Mars Science Laboratory

    Mahaffy, Paul; Farley, Ken; Malespin, Charles; Gellert, Ralph; Grotzinger, John

    2014-05-01

    The quadrupole mass spectrometer (QMS) in the Sample Analysis at Mars (SAM) suite of the Mars Science Laboratory (MSL) has been utilized to secure abundances of 3He, 21Ne, 36Ar, and 40Ar thermally evolved from the mudstone in the stratified Yellowknife Bay formation in Gale Crater. As reported by Farley et al. [1] these measurements of cosmogenic and radiogenic noble gases together with Cl and K abundances measured by MSL's alpha particle X-ray spectrometer enable a K-Ar rock formation age of 4.21+0.35 Ga to be established as well as a surface exposure age to cosmic radiation of 78+30 Ma. Understanding surface exposures to cosmic radiation is relevant to the MSL search for organic compounds since even the limited set of studies carried out, to date, indicate that even 10's to 100's of millions of years of near surface (1-3 meter) exposure may transform a significant fraction of the organic compounds exposed to this radiation [2,3,4]. Transformation of potential biosignatures and even loss of molecular structural information in compounds that could point to exogenous or endogenous sources suggests a new paradigm in the search for near surface organics that incorporates a search for the most recently exposed outcrops through erosional processes. The K-Ar rock formation age determination shows promise for more precise in situ measurements that may help calibrate the martian cratering record that currently relies on extrapolation from the lunar record with its ground truth chronology with returned samples. We will discuss the protocol for the in situ noble gas measurements secured with SAM and ongoing studies to optimize these measurements using the SAM testbed. References: [1] Farley, K.A.M Science Magazine, 342, (2013). [2] G. Kminek et al., Earth Planet Sc Lett 245, 1 (2006). [3] Dartnell, L.R., Biogeosciences 4, 545 (2007). [4] Pavlov, A. A., et al. Geophys Res Lett 39, 13202 (2012).

  10. Heat and mass transfers in a concrete wall with composite liner under accidental conditions

    Billard, Y.; Shekarchi, M.; Debicki, G. E-mail: Gerard.debicki@insa-lyon.fr; Granger, L.; Chauvel, D

    2004-03-01

    The aim of this work was to study the behaviour of a concrete wall, covered with a composite liner and exposed to accidental conditions leading to high temperatures and pressures on a face of the material. In the laboratory, two practical levels of accidental situations (beyond design) have been considered. Firstly, the 'SC1' scenario (accidental conditions) consisted of a rise from ambient conditions to a saturation point of 160 deg. C, and a pressure of 0.75 MPa in 12 h, using the maximum increase possible with the apparatus. This rise was then followed by cooling, leading to 0.22 MPa and 120 deg. C in 24 h. These conditions were maintained for several days. Secondly, a 'SC2' scenario (severe accident conditions) consisted of a rise to a saturation point of 173 deg. C and a pressure of 1 MPa, these conditions were maintained for 24 h before cooling. A cylindrical specimen of 1.3 m of thickness was used. Thermocouples, pressure taps and moisture gauges were implemented before concreting. These devices provided local information, and were mostly distributed in the first 0.30 m of the concrete. The concrete composition (high performance concrete) was the same as that used for the construction of the CIVAUX 2 nuclear power station. Typical experimental results for the evolution of temperature, pressure and water content as functions of time are shown for the two test conditions. The concrete attached to the back of the composite dried, and a mass transfer was induced towards colder zones in the centre of the specimen. The liner acted as a heat insulator and the pressure acting on the back of the composite remained lower than that applied on the composite. The residual adhesion of the liner to the concrete was measured. Finally, the overall results allowed the comparison of situations where the wall was lined and unlined, during exposure to SC1 and SC2 conditions.

  11. Exposure to culturable and total microbiota in cultural heritage conservation laboratories

    Rafał L. Górny

    2016-04-01

    Full Text Available Objectives: To date, the scientific source materials usually focus on microbial contamination of the museum or library collections themselves, while the exposure of persons who professionally deal with this type of objects in cultural heritage conservation laboratories is ignored. Material and Methods: The study was carried out in 9 naturally ventilated conservation laboratories with no history of water damage. Viable (understood as culturable bioaerosol stationary samples were collected in both outdoor and indoor environments using 6-stage Andersen impactor. Simultaneously, stationary and personal indoor bioaerosol measurements were carried out using both Gesamtstaubprobenahme an der Person (GSP and Button filter samplers. These measurements were complemented by evaluation of microbial content in the dust settled on conserved works of art. All impactor, filter, and settled dust samples were quantitatively examined to obtain viable and total concentrations of bacteria and fungi. All isolated microbial strains were taxonomically identified. Results: At workplaces, the concentrations of viable microorganisms in air were below 2000 cfu/m3 and accounted for not more than 5.5% of total microbiota. The study showed that quantitative assessment of viable bioaerosol can be made with an Andersen impactor as well as by using Button and GSP filter samplers, irrespective of whether they are applied for personal or stationary measurements. Compared to the impactor, however, the use of filter samplers for microbial contamination monitoring substantially limits the scope of qualitative information which can be obtained. Size distribution analysis revealed that the largest “load” of microorganisms can penetrate into the respiratory tract between the trachea and terminal bronchi, and thereby may be responsible for allergic inflammations in exposed workers. Conclusions: The precise assessment of microbial hazards in conservation laboratories should comprise

  12. Area and Personal Exposure Levels to Formaldehyde and Its Variation among Undergraduate Students during Gross Anatomy Laboratory Practice

    Pensri Watchalayann; Adul Tapyai; Kajorn Lakchayapakorn

    2014-01-01

    Formaldehyde emitted from the cadavers in Gross Anatomy Laboratory may fluctuate leading to a variation in exposure level of the participants during practice. This study aimed to evaluate the variation of formaldehyde levels and to determine the relationship between area and personal exposure concentration. Formaldehyde levels were measured in six sampling areas repeatedly during three types of study sessions; thoracic, abdominal, and brain and nerve study session. The highest formaldehyde le...

  13. Elucidating multipollutant exposure across a complex metropolitan area by systematic deployment of a mobile laboratory

    Levy, I.; Mihele, C.; Lu, G.; Narayan, J.; Hilker, N.; Brook, J. R.

    2014-07-01

    This study evaluates a deployment strategy of a heavily instrumented mobile lab for characterizing multipollutant spatial patterns based upon a limited number of measurement days spread over different seasons. The measurements obtained through this deployment strategy are used to gain insight into average pollutant levels between routine monitoring sites and in relation to emission sources in the region, as well as to assess correlations between pollutant patterns to better understand the nature of urban air pollutant mixtures. A wide range of locations were part of the deployment in order to characterize the distribution of chronic exposures potentially allowing development of exposure models. Comparison of the mobile lab averages to the available adjacent air quality monitoring network stations to evaluate their representativeness showed that they were in reasonable agreement with the annual averages at the monitoring sites, thus providing some evidence that, through the deployment approach, the mobile lab is able to capture the main features of the average spatial patterns. The differences between mobile lab and network averages varied by pollutant with the best agreement for NO2 with a percentage difference of 20%. Sharp differences in the average spatial distribution were found to exist between different pollutants on multiple scales, particularly on the sub-urban scale, i.e., the neighborhood to street scales. For example, NO2 was observed to be 210-265% higher by the main highway in the study region compared to the nearby urban background monitoring site, while black carbon was higher by 180-200% and particle number concentration was 300% higher. The repeated measurements of near-roadway gradients showed that the rate of change differed by pollutant with elevated concentrations detected up to 600-700 m away for some pollutants. These results demonstrate that through systematic deployment mobile laboratory measurements can be used to characterize average or

  14. Kinematics and kinetics of an accidental lateral ankle sprain

    Kristianslund, Eirik; Bahr, Roald; Krosshaug, Tron

    2011-01-01

    Ankle sprains are common during sporting activities and can have serious consequences. Understanding of injury mechanisms is essential to prevent injuries, but only two previous studies have provided detailed descriptions of the kinematics of lateral ankle sprains and measures of kinetics are missing. In the present study a female handball player accidentally sprained her ankle during sidestep cutting in a motion analysis laboratory. Kinematics and kinetics were calculated from 240 Hz recordi...

  15. Juvenile roach (Rutilus rutilus) increase their anaerobic metabolism in response to copper exposure in laboratory conditions.

    Maes, Virginie; Betoulle, Stéphane; Jaffal, Ali; Dedourge-Geffard, Odile; Delahaut, Laurence; Geffard, Alain; Palluel, Olivier; Sanchez, Wilfried; Paris-Palacios, Séverine; Vettier, Aurélie; David, Elise

    2016-07-01

    This study aims to determine the potential impairment of cell energy synthesis processes (glycolysis and respiratory chain pathways) by copper in juvenile roach at different regulation levels by using a multi-marker approach. Juvenile roach were exposed to 0, 10, 50, and 100 µg/L of copper for 7 days in laboratory conditions. The glycolysis pathway was assessed by measuring the relative expression levels of 4 genes encoding glycolysis enzymes. The respiratory chain was studied by assessing the electron transport system and cytochrome c oxidase gene expression. Muscle mitochondria ultrastructure was studied, and antioxidant responses were measured. Furthermore, the main energy reserves-carbohydrates, lipids, and proteins-were measured, and cellular energy was evaluated by measuring ATP, ADP, AMP and IMP concentrations. This study revealed a disturbance of the cell energy metabolism due to copper exposure, with a significant decrease in adenylate energy charge in roach exposed to 10 μg/L of copper after 1 day. Moreover, ATP concentrations significantly decreased in roach exposed to 10 μg/L of copper after 1 day. This significant decrease persisted in roach exposed to 50 µg/L of copper after 7 days. AMP concentrations increased in all contaminated fish after 1 day of exposure. In parallel, the relative expression of 3 genes encoding for glycolysis enzymes increased in all contaminated fish after 1 day of copper exposure. Focusing on the respiratory chain, cytochrome c oxidase gene expression also increased in all contaminated fish at the two time-points. The activity of the electron transport system was not disturbed by copper, except in roach exposed to 100 µg/L of copper after 1 day. Copper induced a metabolic stress. Juvenile roach seemed to respond to the ensuing high energy demand by increasing their anaerobic metabolism, but the energy produced by the anaerobic metabolism is unable to compensate for the stress induced by copper after 7

  16. A laboratory exposure system to study the effects of aging on super-micron aerosol particles

    Santarpia, Joshua; Sanchez, Andres L.; Lucero, Gabriel Anthony; Servantes, Brandon Lee; Hubbard, Joshua Allen

    2014-02-01

    A laboratory system was constructed that allows the super-micron particles to be aged for long periods of time under conditions that can simulate a range of natural environments and conditions, including relative humidity, oxidizing chemicals, organics and simulated solar radiation. Two proof-of-concept experiments using a non-biological simulant for biological particles and a biological simulant demonstrate the utility of these types of aging experiments. Green Visolite®, which is often used as a tracer material for model validation experiments, does not degrade with exposure to simulated solar radiation, the actual biological material does. This would indicate that Visolite® should be a good tracer compound for mapping the extent of a biological release using fluorescence as an indicator, but that it should not be used to simulate the decay of a biological particle when exposed to sunlight. The decay in the fluorescence measured for B. thurengiensis is similar to what has been previously observed in outdoor environments.

  17. Accidental inflation in the landscape

    We study some aspects of fine tuning in inflationary scenarios within string theory flux compactifications and, in particular, in models of accidental inflation. We investigate the possibility that the apparent fine-tuning of the low energy parameters of the theory needed to have inflation can be generically obtained by scanning the values of the fluxes over the landscape. Furthermore, we find that the existence of a landscape of eternal inflation in this model provides us with a natural theory of initial conditions for the inflationary period in our vacuum. We demonstrate how these two effects work in a small corner of the landscape associated with the complex structure of the Calabi-Yau manifold P4[1,1,1,6,9] by numerically investigating the flux vacua of a reduced moduli space. This allows us to obtain the distribution of observable parameters for inflation in this mini-landscape directly from the fluxes

  18. Assessment of risks associated to ionizing radiations: lung cancers after domestic radon exposure and thyroid cancers after accidental exposure to radioactive iodines; Evaluation des risques associes aux rayonnements ionisants: cancers du poumon apres exposition domestique au radon et cancers de la thyroide apres exposition accidentelle aux iodes radioactifs

    Catelinois, O

    2004-09-15

    The aim of this work is to develop a critical analysis of quantitative risk assessment in the field of ionizing radiation and to provide new estimates of attributable risks for particular situations of environmental exposure to ionizing radiation. This work is based on knowledge about dose-response relationships and ionizing radiation exposure of the general population. The work focuses on two different situations that both present an important interest for public health: lung cancer associated with domestic radon exposures (natural situation) and thyroid cancer associated with the Chernobyl accident fallout (accidental situation). The assessment of lung cancer risk associated with domestic radon exposure considers 10 dose-response relationships resulting from miner cohorts and case-control studies in the general population. A critical review of available data on smoking habits has been performed and allowed to consider the interactions between radon and tobacco. The exposure data come from measurements campaigns carried out since the beginning of the 1980 by the Institute for Radiation protection and Nuclear Safety and the Health General Directory in France. The French lung cancer mortality data are provided by the I.N.S.E.R.M.. Estimates of the number of attributable cancers are carried out for the whole country, stratified by 8 large regions (Z.E.A.T.) and by 96 departments for the year 1999 allowing to perform a sensibility analysis according to the geographical level of calculation. Uncertainties associated to risk coefficients and exposures have been quantified and it's impact on risk estimates is calculated. The estimated number of deaths attributable to domestic radon exposure ranges from 543 (90% uncertainty interval (U.I.): 75-1,097) to 3,108 (90% U.I.: 2,996-3,221). The corresponding risk fractions range from 2.2% (90% U.I.: 0.3%-4.4%) to 12.4% (90% U.I.: 11.9%-12.8%). The assessment of thyroid cancer risk in the most exposed area of France due to

  19. Whole-body heat exposure induces membrane changes in spermatozoa from the cauda epididymidis of laboratory mice

    Wechalekar, Harsha; Setchell, Brian P.; Peirce, Eleanor J.; Ricci, Mario; Leigh, Chris; Breed, William G.

    2010-01-01

    This study was carried out to determine if exposure to hot environmental temperatures had a direct, detrimental effect on sperm quality. For this the effect of whole-body heat exposure on epididymal spermatozoa of laboratory mice was investigated. C57BL/6 mice (n = 7) were housed in a microclimate chamber at 37°C–38°C for 8 h per day for three consecutive days, while control mice (n = 7) were kept at 23°C–24°C. Cauda epididymal spermatozoa were obtained 16 h after the last heat treatment. The...

  20. Acidentes de trabalho com exposição a material biológico entre os profissionais de Enfermagem Accidentes de trabajo con exposición a material biológico entre profesionales de enfermería Occupational accidents with exposure to human tissue in nursing professionals

    Thiago Moura de Araújo

    2012-07-01

    conclusión de que se debe prestar más atención a la prevención de estos accidentes, así como al rigor del seguimiento tras la exposiciónocupacional.The aim of this research was to identify the types of accidents among workers involving human tissue in order to raise the profile of the victims the type of exposure, and the circumstances in which accidents occurred. This was a retrospective and descriptive study based on documents. Data collection was performed using the records of the Information System for Notifiable Diseases(SINAN in a referral hospital for infectious diseases in Ceará a total of 777 cases.The results show that 94.7 of those affected were female 57.5% were nursing assistants, 88% of cases were due to percutaneous exposure 70.1% being caused by hollow needles, 87.3% with exposure to blood, and 13.7% were related to inappropriate disposal ofperforating objects at the bench, bedside, etc.. We conclude that more attention must be given to the prevention of such accidents, as well as to strict follow-up after occupational exposure.

  1. Mathematical model for predicting the probability of acute mortality in a human population exposed to accidentally released airborne radionuclides. Final report for Phase I

    Filipy, R.E.; Borst, F.J.; Cross, F.T.; Park, J.F.; Moss, O.R.; Roswell, R.L.; Stevens, D.L.

    1980-05-01

    A mathematical model was constructed for the purpose of predicting the fraction of human population which would die within 1 year of an accidental exposure to airborne radionuclides. The model is based on data from laboratory experiments with rats, dogs and baboons, and from human epidemiological data. Doses from external, whole-body irradiation and from inhaled, alpha- and beta-emitting radionuclides are calculated for several organs. The probabilities of death from radiation pneumonitis and from bone marrow irradiation are predicted from doses accumulated within 30 days of exposure to the radioactive aerosol. The model is compared with existing similar models under hypothetical exposure conditions. Suggestions for further experiments with inhaled radionuclides are included. 25 refs., 16 figs., 13 tabs.

  2. Acidentes ocupacionais por exposição a material biológico entre a equipe multiprofissional do atendimento pré-hospitalar Accidentes ocupacionales por exposición a material biológico entre el equipo multiprofesional de atención pre hospitalaria Occupational accidents due to exposure to biological material in the multidisciplinary team of the emergency service

    Adriana Cristina Oliveira

    2009-09-01

    ñamiento serológico, 61,2%. Estuvieron asociados al accidente: tiempo en la institución, (Odds ratio-OR 2,84; Intervalo de confianza-IC 95% 1,22-6,62, asignado en la Unidad de Soporte Avanzado, (OR 4,18; IC 95% 1,64-10,64; interacción: tiempo en la institución y asignado en la Unidad de Soporte Básico, (OR 0,27; IC 95% 0,07-1,00. Se sugiere: la implantación de protocolos después de accidentes, con el objetivo de reducirlos; la subnotificación y el aumento del acompañamiento después del accidente.This transversal, survey-based research was carried out with a multiprofessional emergency care team in Belo Horizonte, between June and December 2006. The study aimed at estimating the incidence of occupational accidents by exposure to biological material, post-accidents conducts and demographic determinant factors. The study applied a structured questionnaire and descriptive analyses, as well as incidence calculations and logistic regression. The incidence of accidents with biological material reached 20.6%, being 40.8% by sharp materials and 49.0% by body fluids; 35.3% of the accidents took place among physicians and 24.0% among nurses. Post-accidents procedures: no medical assessment, 63.3%; under-notification, 81.6%; no conduct, 55.0%; and no serological follow-up, 61.2%. Factors associated with accidents: working time in the institution (Odds Ratio - OR, 2.84; Credible Interval - CI 95% - 1.22-6.62; working in advanced support units (OR=4.18; CI 95% - 1.64-10.64; and interaction between working time in the institution and working in Basic Support Unit (OR 0.27; CI 95% - 0.07-1.00. In order to reduce accidents, the implementation of post-accident protocols and follow-up, as well as under-notification norms, are suggested.

  3. A comparison of a laboratory and field study of annoyance and acceptability of aircraft noise exposures. [human reactions and tolerance

    Borsky, P. N.

    1977-01-01

    Residents living in close, middle and distant areas from JFK Airport were included in a field interview and laboratory study. Judgments were made of simulated aircraft noise exposures of comparable community indoor noise levels and mixes of aircraft. Each group of subjects judged the levels of noise typical for its distance area. Four different numbers of flyovers were tested: less than average for each area, the approximate average, the peak number, or worst day, and above peak number. The major findings are: (1) the reported integrated field annoyance is best related to the annoyance reported for the simulated approximate worst day exposure in the laboratory; (2) annoyance is generally less when there are fewer aircraft flyovers, and the subject has less fear of crashes and more favorable attitudes toward airplanes; (3) beliefs in harmful health effects and misfeasance by operators of aircraft are also highly correlated with fear and noise annoyance; (4) in direct retrospective comparisons of number of flights, noise levels and annoyance, subjects more often said the worst day laboratory exposured more like their usual home environments; and (5) subjects do not expect an annoyance-free environment. Half of the subjects can accept an annoyance level of 5 to 6 from a possible annoyance range of 0 to 9, 28% can live with an annoyance intensity of 7, and only 5% can accept the top scores of 8 to 9.

  4. Range-Finding Risk Assessment of Inhalation Exposure to Nanodiamonds in a Laboratory Environment

    Koivisto, Antti J.; Palomäki, Jaana E.; Viitanen, Anna-Kaisa; Siivola, Kirsi M.; Koponen, Ismo K.; Yu, Mingzhou; Kanerva, Tomi S.; Norppa, Hannu; Alenius, Harri T.; Hussein, Tareq; Savolainen, Kai M.; Hämeri, Kaarle J.

    2014-01-01

    This study considers fundamental methods in occupational risk assessment of exposure to airborne engineered nanomaterials. We discuss characterization of particle emissions, exposure assessment, hazard assessment with in vitro studies, and risk range characterization using calculated inhaled doses and dose-response translated to humans from in vitro studies. Here, the methods were utilized to assess workers’ risk range of inhalation exposure to nanodiamonds (NDs) during handling and sieving of ND powder. NDs were agglomerated to over 500 nm particles, and mean exposure levels of different work tasks varied from 0.24 to 4.96 µg·m−3 (0.08 to 0.74 cm−3). In vitro-experiments suggested that ND exposure may cause a risk for activation of inflammatory cascade. However, risk range characterization based on in vitro dose-response was not performed because accurate assessment of delivered (settled) dose on the cells was not possible. Comparison of ND exposure with common pollutants revealed that ND exposure was below 5 μg·m−3, which is one of the proposed exposure limits for diesel particulate matter, and the workers’ calculated dose of NDs during the measurement day was 74 ng which corresponded to 0.02% of the modeled daily (24 h) dose of submicrometer urban air particles. PMID:24840353

  5. A comparison of engineering controls for formaldehyde exposure during grossing activities in health care anatomic pathology laboratories.

    Xu, Wenhai; Stewart, Erica J

    2016-07-01

    This article for the first time reports a large set of monitoring results for formaldehyde exposure during grossing activities in health care anatomic pathology laboratories, and compares the effectiveness of different local exhaust ventilation systems on the exposure. To control the confounding effects from grossing work load, sampling duration, and the sizes of specimens grossed, only 15-min short-term personal exposure samples collected during large tissue specimen grossing were used for the comparison of the effectiveness of these local exhaust systems. While we also collected long-term 8-hr time weighted average samples, these are not treated in this analysis. The systems examined were canopy receiving hoods, slot exhausts, and commercially available pre-manufactured backdraft grossing stations, both recirculating and ducted exhaust types. Out of over 2,000 personal short-term air samples, 307 samples from 163 surveys met the data selection criteria. Over a third of the data were less than the analytical laboratory limits of detection. Using the robust maximum likelihood estimation method for multiple limits of detection, the mean and geometric mean of the dataset for each type of local exhaust system were found to be less than the short-term personal exposure regulatory limit of 2 ppm. Nonparametric Wilcoxon rank-sum pairwise tests of five types of engineering controls showed a statistically significant difference among these controls, with the most effective being the manufactured backdraft grossing stations ducted to the outside, and the least effective being canopy exhaust systems and manufactured filtered recirculating grossing stations. Finally, exposure with each of the major engineering control types was rated by the American Industrial Hygiene Association exposure control rating scheme. PMID:26861729

  6. Accidental Bolus of Parenteral Nutrition.

    Lodeserto, Frank; Al-Jaghbeer, Mohammed; Huang, David

    2016-08-01

    There is a paucity of data that exists regarding acute toxicity and management in the setting of parental nutrition (PN) overdose. We describe a case of a patient who received an accidental rapid bolus of PN and fat emulsion. She developed a seizure, metabolic acidosis, arrhythmias, myocardial ischemia, altered mental status, hypotension, and hypoxemia likely caused by elevated triglycerides, leading to a hyperviscosity syndrome. After failing standard therapy, she was successfully treated with a single-volume plasma exchange with resolution of symptoms. Fat emulsion or intravenous lipid emulsion and much of its safety have been recently described in its use as a rescue therapy in resuscitation from drug-related toxicity. Elevated serum triglyceride levels can result in a picture similar to a hyperviscosity syndrome. Plasma exchange is a known therapeutic modality for the management of hyperviscosity syndrome and a novel therapy in the treatment of hyperviscosity syndrome due to fat emulsion therapy. In a patient receiving PN with development of rapid deterioration of clinical status, without an obvious etiology, there should be consideration of PN overdose. A rapid assessment and treatment of severe electrolyte abnormalities should be undertaken immediately to prevent life-threatening cardiovascular and central nervous system collapse. If fat emulsion was rapidly coadministered and there are signs and symptoms of hyperviscosity syndrome, then consideration should be given to plasma exchange as an effective therapeutic treatment option. PMID:25666023

  7. Evaluation and mitigation of accidental releases of radioactivity

    One result of the workshop was, that even in the case of severe accident sequences in modern nuclear power plants (other facilities were not discussed), there will be enough time to take active measures in order to lower the emissions and to diminish the consequences inside and outside of the plant. On the whole, new evidence from Harrisburg show that previously estimated accidental emissions, especially of radiologically relevant nuclides, have been rather conservative and that much lower emissions are possible, if the above measures are considered. Under accident conditions, models to predict radiation exposure must be applied under the event of a short-term release. (orig./DG)

  8. Preliminary study: Formaldehyde exposure in laboratories of Sharjah university in UAE

    Hafiz Omer Ahmed

    2011-01-01

    Full Text Available Objectives : Laboratory technicians, students, and instructors are at high risk, because they deal with chemicals including formaldehyde. Thus, this preliminary study was conducted to measure the concentration of formaldehyde in the laboratories of the University of Sharjah in UAE. Materials and Methods: Thirty-two air samples were collected and analyzed for formaldehyde using National Institute for Occupational Safety and Health (NIOSH method 3500. In this method, formaldehyde reacts with chromotropic acid in the presence of sulfuric acid to form a colored solution. The absorbance of the colored solution is read in spectrophotometer at wavelength 580 nm and is proportional to the quantity of the formaldehyde in the solution. Results: For the anatomy laboratory and in the presence of the covered cadaver, the mean concentration of formaldehyde was found to be 0.100 ppm with a range of 0.095-0.105 ppm. Whereas for the other laboratories, the highest mean concentration of formaldehyde was 0.024 ppm in the general microbiology laboratory and the lowest mean concentration of formaldehyde was 0.001 ppm in the environmental health laboratory. The 8-hour (time-weighted average concentration of formaldehyde was found to be ranging between 0.0003 ppm in environmental health laboratory and 0.026 ppm in the anatomy laboratory. Conclusions: The highest level of concentration of formaldehyde in the presence of the covered cadaver in anatomy laboratory exceeded the recommended ceiling standard established by USA-NIOSH which is 0.1 ppm, but below the ceiling standard established by American Conference of Governmental Industrial Hygienists which is 0.3 ppm. Thus, it is recommended that formaldehyde levels should be measured periodically specially during the dissection in the anatomy laboratory, and local exhaust ventilation system should be installed and personal protective equipment such as safety glass and gloves should be available and be used to prevent

  9. An accidental poisoning with mitragynine.

    Karinen, Ritva; Fosen, Jan Toralf; Rogde, Sidsel; Vindenes, Vigdis

    2014-10-24

    An increasing number of drugs of abuse are sold word wide over the internet. Names like "legal highs", "herbal highs" etc. give the impression that these are safe products, although the risk of fatal reactions might be substantial. Leaves from the plant Mitragyna speciosa, contain active compounds like mitragynine and 7-hydroxymitragynine. It has been reported that the potency of 7-hydroxymitragynine at the μ-opioid receptor is 30 times higher than that of mitragynine and 17 times higher than that of morphine. Case reports regarding poisoning with Kratom are reported, but the toxic or lethal ranges for the concentrations of the active substances have not been established, and concentrations of 7-hydroxymitragynine have not been reported previously. We present a case report where a middle aged man was found dead at home. The deceased had a history of drug abuse and mental illness for several years. At autopsy, there were no significant pathological findings. Post-mortem analysis of peripheral blood revealed: zopiclone 0.043mg/L, citalopram 0.36mg/L and lamotrigine 5.4mg/L, i.e. concentrations regularly seen after therapeutic ingestion of these drugs. Additionally mitragynine 1.06mg/L and 7-hydroxymitragynine 0.15mg/L were detected in blood and both also in urine. The high concentrations of mitragynine and 7-hydroxymitragynine indicate that the cause of death is intoxication by these substances; and the circumstances point toward the manner of death being accidental. We recommend that both mitragynine and 7-hydroxymitragynine are analyzed for in cases with suspected Kratom intoxication. PMID:25453780

  10. Mixed and low-level waste treatment project: Appendix C, Health and safety criteria for the mixed and low-level waste treatment facility at the Idaho National Engineering Laboratory

    This report describes health and safety concerns associated with the Mixed and Low-level Waste Treatment Facility at the Idaho National Engineering Laboratory. Various hazards are described such as fire, electrical, explosions, reactivity, temperature, and radiation hazards, as well as the potential for accidental spills, exposure to toxic materials, and other general safety concerns

  11. Mixed and low-level waste treatment project: Appendix C, Health and safety criteria for the mixed and low-level waste treatment facility at the Idaho National Engineering Laboratory

    Neupauer, R.M.; Thurmond, S.M.

    1992-09-01

    This report describes health and safety concerns associated with the Mixed and Low-level Waste Treatment Facility at the Idaho National Engineering Laboratory. Various hazards are described such as fire, electrical, explosions, reactivity, temperature, and radiation hazards, as well as the potential for accidental spills, exposure to toxic materials, and other general safety concerns.

  12. Mixed and low-level waste treatment project: Appendix C, Health and safety criteria for the mixed and low-level waste treatment facility at the Idaho National Engineering Laboratory. Part 1, Waste streams and treatment technologies

    Neupauer, R.M.; Thurmond, S.M.

    1992-09-01

    This report describes health and safety concerns associated with the Mixed and Low-level Waste Treatment Facility at the Idaho National Engineering Laboratory. Various hazards are described such as fire, electrical, explosions, reactivity, temperature, and radiation hazards, as well as the potential for accidental spills, exposure to toxic materials, and other general safety concerns.

  13. Cellular and aqueous microcystin-LR following laboratory exposures of Microcystis aeruginosa to copper algaecides.

    Iwinski, Kyla J; Calomeni, Alyssa J; Geer, Tyler D; Rodgers, John H

    2016-03-01

    Microcystin release from algal cells influences use of copper-algaecides in water resources. Accurate data regarding relationships between copper-algaecide exposures and responses of microcystin-producing algae are needed to make informed management decisions. Responses of Microcystis aeruginosa were measured in terms of cellular microcystin-LR (MC-LR), aqueous MC-LR, and chlorophyll-a following exposure to CuSO4 and copper-ethanolamine. Comparisons were made between treated and untreated samples, and copper formulations. EC50s and slopes for M. aeruginosa responses to copper exposures were calculated. Algal responses followed a sigmoidal exposure-response relationship, and cellular MC-LR and chlorophyll-a were negatively related to copper concentrations. Aqueous MC-LR increased with copper concentrations, although the increase in aqueous MC-LR was not proportional to decreases in cellular MC-LR and chlorophyll-a. Cellular MC-LR and chlorophyll a declined at a greater rate than aqueous MC-LR increased. Total MC-LR was less than untreated controls following copper exposure. Differences were measured between copper formulations in terms of aqueous and total MC-LR concentrations at concentrations of 0.5 and 1.0 mg Cu L-1. Aqueous and total MC-LR were greater (10-20%) following exposure to CuSO4 compared to copper-ethanolamine one day following exposure. The positive relationship between copper concentration and aqueous MC-LR at 0.07-1.0 mg Cu L-1 demonstrates that lower copper concentrations were as effective as higher concentrations in controlling M. aeruginosa while decreasing the total amount of MC-LR, and minimizing the proportion of MC-LR released to the aqueous-phase. Results serve to support more accurate risk evaluations of MC-LR concentrations when M. aeruginosa is exposed to copper-algaecides and when it is untreated. PMID:26761600

  14. Annual course of retraining for the occupational exposure personnel of the laboratory of internal dosimetry

    The general objective of this report is to instruct the personnel in the basic concepts of radiological protection and in the Manual of Procedures of Radiological Safety of the Laboratory of Internal Dosimetry. Also, to exchange experiences during the activities that are carried out in the laboratory and in the knowledge of abnormal situations. The referred Manual consists of 14 procedures and 5 instructions which are listed in annex of this document. The content of this course consists of three topics: 1. Basic principles of radiological protection to reduce the received dose equivalent. 2. Use of radiation measurer equipment. 3. Emergency procedures of the laboratory of internal dosimetry. (Author)

  15. Environmental behaviour of accidentally released radionuclides in urban environments

    After a nuclear accident several radionuclides may be released and may contribute to the exposure of members of the public. After the passage of the radioactive cloud, doses to members of the public are mainly due to deposited radionuclides on the ground and other environmental surfaces. For the long-term it is already known that exposure is dominated by Cs-137, although Sr isotopes may also have a significant contribution is some specific environments, related to internal exposure pathways. However, in the first year, Ru and I isotopes may significantly contribute to the exposure of members of the public, from both external and internal exposure pathways. The objective of this work was to gather data on the environmental behaviour of Sr, I and Ru isotopes on urban environments and its contributions to the population exposure, aiming the support for decision making processes on countermeasures to protect people after an accidental release. Results on relative relevance of radionuclides and pathways for the exposure for members of the public, as a function of age and time after the release, are discussed. (author)

  16. Assessing the Exposure and Relative Sensitivity of Native Freshwater Mussels to Environmental Stressors and Laboratory Conditions

    1. Expands the database for pesticide toxicity on native freshwater mussels. 2. Aids in determining any potential differences in toxic sensitivity of gravid female mussel attributed to age and laboratory holding times. 3. Aids in determining potential differences in juvenile ...

  17. QUALITY OF RADIOGRAPHIC IMAGES: LABORATORY EVALUATION OF INTRAORAL FILMS, FILTERS, COLLIMATORS, AND RADIATION EXPOSURE

    TAMBURUS José Roberto

    1997-01-01

    Full Text Available In order to evaluate density, radiographic contrast and dose of radiation exposure, the author analyzed 80 radiographs containing 640 optical density data of the images of a penetrometer, exposed to the radiation beam with combinations between D and E periapical films, aluminum and copper/aluminum filters, and circular or rectangular collimators. The data obtained were analyzed by ANOVA and allowed the following conclusions: 1 aluminum filtration resulted in improved image contrast; 2 the use of group D film and an aluminum filter produced improved image contrast quality; 3 the rectangular collimator contributed to the production of improved contrast and to the reduction of radiation exposure, but did not affect density; 4 the combination of copper/aluminum filter, E group film and rectangular collimation significantly reduced radiation exposure.

  18. Susceptibility of Ixodes scapularis (Acari: Ixodidae) to Metarhizium brunneum F52 (Hypocreales: Clavicipitaceae) using three exposure assays in the laboratory.

    Bharadwaj, Anuja; Stafford, Kirby C

    2012-02-01

    An emulsifiable concentrate (EC) and granular (G) formulation of the entomopathogenic fungus, Metarhizium brunneum strain F52 (formerly Metarhizium anisopliae strain F52) were tested against unfed adults and nymphs of Ixodes scapularis Say in the laboratory. Three exposure methods; dip, surface contact, and direct spray application, and three exposure time intervals (3, 30, and 300 min) were used to evaluate the EC formulation. Application rates ranged from 2.6 x 10(2) to 2.6 x 10(8) conidia/cm2. The surface treatment was used for granular formulation with concentrations ranging from 2.3 x 10(5) to 2.3 x 10(7) conidia/cm2 for same three exposure times. Both the EC and G formulations of this fungus were highly pathogenic against I. scapularis adults and nymphs. Logistic regression analysis found formulation, spore concentration, time of exposure, and observation period were significant or highly significant factors influencing tick mortality. For adult I. scapularis, the spray application with the EC formulation of M. brunneum F52 resulted in a lower LC50 (5.9 x 10(4) conidia/cm2) at 30 min than surface exposure to the EC (LC50 = 1.3 x 10(6) conidia/cm2) or G formulation (LC50 = 8.1 x 10(5) conidia/cm2). At higher concentrations, fungal activity was evident in adult I. scapularis held at 5 degrees C suggesting the fungus may provide control in the cooler fall season. While the observed pathogenicity of a fungus against ticks can be dependent upon the bioassay assessment, we found nymphs and adults of I. scapularis to be highly susceptible to M. brunneum F52, regardless of the exposure method used. PMID:22420275

  19. Mortalidad intrahospitalaria por accidente cerebrovascular

    Federico Rodríguez Lucci

    2013-08-01

    Full Text Available La mortalidad global por accidente cerebrovascular (ACV ha disminuido en las últimas tres décadas, probablemente debido a un mejor control de los factores de riesgo vascular. La mortalidad hospitalaria por ACV ha sido tradicionalmente estimada entre 6 y 14% en la mayoría de las series comunicadas. Sin embargo, los datos de ensayos clínicos recientes sugieren que esta cifra sería sustancialmente menor. Se revisaron datos de pacientes internados con diagnóstico de ACV del Banco de Datos de Stroke de FLENI y los registros institucionales de mortalidad entre los años 2000 y 2010. Los subtipos de ACV isquémicos se clasificaron según criterios TOAST y los ACV hemorrágicos en hematomas intrapanquimatosos, hemorragias subaracnoideas aneurismáticas, malformaciones arteriovenosas y otros hematomas intraparenquimatosos. Se analizaron 1514 pacientes, 1079 (71% con ACV isquémico (grandes vasos 39%, cardioembólicos 27%, lacunares 9%, etiología indeterminada 14%, otras etiologías 11% y 435 (29% con ACV hemorrágico (intraparenquimatosos 27%, hemorragia subaracnoidea 30%, malformaciones arteriovenosas 25% y otros hematomas espontáneos 18%. Se registraron 38 muertes intrahospitalarias (17 ACV isquémicos y 21 ACV hemorrágicos, representando una mortalidad global del 2.5% (1.7% en ACV isquémicos y 4.8% en ACV hemorrágicos. No se registraron muertes asociadas al uso de fibrinolíticos endovenosos. La mortalidad intrahospitalaria en pacientes con ACV isquémico y hemorrágico en nuestro centro fue baja. El manejo en un centro dedicado a las enfermedades neurológicas y el enfoque multidisciplinario por personal médico y no médico entrenado en el cuidado de la enfermedad cerebrovascular podrían explicar, al menos en parte, estos resultados.

  20. Estudo sobre os acidentes de trabalho com exposição aos líquidos corporais humanos em trabalhadores da saúde de um hospital universitário Estudio sobre los accidentes de trabajo con exposicíon a líquidos corporales humanos en trabajadores de la salud de un hospital universitario Study of work accidents related to human body fluids exposure among health workers at a university hospital

    Ana Cristina Balsamo

    2006-06-01

    trabajadores declaró que el accidente "simplemente aconteció" y el 29,17% no tenía sugerencias. Este estudio aportó herramientas importantes para la revisión y elaboración de estrategias de prevención de los accidentes con exposición a los líquidos corporales humanos.This descriptive and exploratory study from a quantitative approach aimed to characterize workers who were victims of work accidents related to human body fluids exposure and to evaluate the accident victim care protocol. The population consisted of 48 workers who were victims of work accidents involving exposure to human body fluids, from July 2000 to June 2001. Data were collected through a form and interviews. Results showed that nursing workers presented higher accident risk levels and that 87.50% involved piercing and cutting material, such as needles and butterflies (70%. As to the accident-related situation/activity, the workers indicated that 25% were due to an "inadequate act during the procedure"; 19.64% mentioned that "it happened" and 29.17% answered that they did not have any suggestion. This study provided important tools to review and elaborate strategies to prevent accidents involving exposure to human body fluids.

  1. 40 CFR 79.60 - Good laboratory practices (GLP) standards for inhalation exposure health effects testing.

    2010-07-01

    ... the CAA, it shall be a violation of this section and a violation of this rule (40 CFR part 79, subpart... under 40 CFR part 79 and may require the sponsor to develop data in accordance with the requirements of...) standards for inhalation exposure health effects testing. 79.60 Section 79.60 Protection of...

  2. Adverse effect of diesel engine produced particulate matter on various stone types and concrete: a laboratory exposure experiment

    Farkas, Orsolya; Szabados, György; Antal, Ákos; Török, Ákos

    2015-04-01

    The effect of particulate matter on construction materials have been studied under laboratory conditions. For testing the adverse effects of diesel soot and particulate matter on stone and concrete a small scale laboratory exposure chamber was constructed. Blocks of 9 different stone types and concrete was placed in the chamber and an exhaust pipe of diesel engine was diverted into the system. Tested stones included: porous limestone, cemented non-porous limestone, travertine, marble, rhyolite tuff, andesite and granite. The engine was operated for 10 hours and the produced particulate matter was diverted directly to the surface of the material specimens of 3 cm in diameter each. Working parameters of the engine were controlled; the composition of the exhaust gas, smoke value and temperature were continuously measured during the test. Test specimens were documented and analysed prior to exposure and after the exposure test. Parameters such colorimetric values, weight, surface properties, mineralogical compositions of the test specimens were recorded. The working temperature was in the order of 300°C-320°C. The gas concentration was in ppm as follows: 157 CO; 5.98 CO2, 34.3 THC; 463 NOx; 408 NO; 12.88 O2. Our tests have demonstrated that significant amount of particulate matter was deposited on construction materials even at a short period of time; however the exposure was very intense. It also indicates that that the interaction of particulate matter and aerosol compounds with construction materials in urban areas causes rapid decay and has an adverse effect not only on human health but also on built structures.

  3. Laboratory tests for group and individual exposures of Arion lusitanicus Mabille slugs to different molluscicide baits

    Bojan Stojnić; Marina Vukša; Goran Jokić

    2008-01-01

    Molluscicide baits based on different active ingredients were tested in a seven-day laboratory trial on juveniles and young adults of Arion lusitanicus Mabille slug collected in ruderal sites during June and July of 2008. Before setting the trial, the slugs were adapted to laboratory conditions. The testing was conducted using a modified version of the method proposed by Godan (1983) and Wiktor (1989). The slugs were kept in arenas under controlled conditions (20-24oC temperature, 80-90% rela...

  4. Exposure estimates using urban plume dispersion and traffic microsimulation models

    Brown, M.J.; Mueller, C.; Bush, B.; Stretz, P.

    1997-12-01

    The goal of this research effort was to demonstrate a capability for analyzing emergency response issues resulting from accidental or mediated airborne toxic releases in an urban setting. In the first year of the program, the authors linked a system of fluid dynamics, plume dispersion, and vehicle transportation models developed at Los Alamos National Laboratory to study the dispersion of a plume in an urban setting and the resulting exposures to vehicle traffic. This research is part of a larger laboratory-directed research and development project for studying the relationships between urban infrastructure elements and natural systems.

  5. 29 CFR 1910.1450 - Occupational exposure to hazardous chemicals in laboratories.

    2010-07-01

    ... Hazard Communication Standard (29 CFR 1910.1200) provide further guidance in defining the scope of health... (29 CFR 1910.1200) including the requirements for preparation of material safety data sheets and... laboratories. 1910.1450 Section 1910.1450 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL...

  6. Growth Responses of Fish During Chronic Exposure of Metal Mixture under Laboratory Conditions

    Saima Naz and Muhammad Javed

    2013-07-01

    Full Text Available Growth responses of five fish species viz. Catla catla, Labeo rohita, Cirrhina mrigala, Ctenopharyngodon idella and Hypophthalmichthys molitrix were determined, separately, under chronic exposure of binary mixture of metals (Zn+Ni at sub-lethal concentrations (1/3rd of LC50 for 12 weeks. Randomized complete block design (RCBD was followed to conduct this research work. The groups (10 fish each of Catla catla, Labeo rohita, Cirrhina mrigala, Ctenopharyngodon idella and Hypophthalmichthys molitrix having almost similar weights were investigated for their growth responses and metals bioaccumulation patterns in their body organs during chronic exposure of Zn+Ni mixture. The bioaccumulation of metals in the fish body organs viz. gills, liver, kidney, fins, bones, muscle and skin were also determined before and after growth trails under the stress of metals mixture. The exposure of fish to sub-lethal concentrations of mixture caused significant impacts on the average wet weight increments of five fish species. Ctenopharyngodon idella and Labeo rohita attained significantly higher weights, followed by that of Hypophthalmichthys molitrix, Cirrhina mrigala and Catla catla. However, the growth of metals mixture exposed fish species was significantly lesser than that of control fish (un-stressed. Significantly variable condition factor values reflected the degree of fish well-beings that correlated directly with fish growth and metal exposure concentration. Any significant change in feed intake, due to stress, is reflected in terms of fish growth showing the impacts of metal mixture on fish growth were either additive or antagonist / synergistic. Accumulation of all the metals in fish body followed the general order: liver>kidney>gills> skin >muscle> fins >bones.

  7. Bridging the gap between sample collection and laboratory analysis: using dried blood spots to identify human exposure to chemical agents

    Hamelin, Elizabeth I.; Blake, Thomas A.; Perez, Jonas W.; Crow, Brian S.; Shaner, Rebecca L.; Coleman, Rebecca M.; Johnson, Rudolph C.

    2016-05-01

    Public health response to large scale chemical emergencies presents logistical challenges for sample collection, transport, and analysis. Diagnostic methods used to identify and determine exposure to chemical warfare agents, toxins, and poisons traditionally involve blood collection by phlebotomists, cold transport of biomedical samples, and costly sample preparation techniques. Use of dried blood spots, which consist of dried blood on an FDA-approved substrate, can increase analyte stability, decrease infection hazard for those handling samples, greatly reduce the cost of shipping/storing samples by removing the need for refrigeration and cold chain transportation, and be self-prepared by potentially exposed individuals using a simple finger prick and blood spot compatible paper. Our laboratory has developed clinical assays to detect human exposures to nerve agents through the analysis of specific protein adducts and metabolites, for which a simple extraction from a dried blood spot is sufficient for removing matrix interferents and attaining sensitivities on par with traditional sampling methods. The use of dried blood spots can bridge the gap between the laboratory and the field allowing for large scale sample collection with minimal impact on hospital resources while maintaining sensitivity, specificity, traceability, and quality requirements for both clinical and forensic applications.

  8. Characterisation of initial atmospheric corrosion carbon steels by field exposure and laboratory simulation

    The early stages of the evolution of atmospheric corrosion of carbon steels exposed in both a laboratory simulated and a natural atmosphere environment in Shenyang have been observed by in situ scanning electron microscopy. In the case of laboratory cyclic wet-dry tests, even though the chloride content level is very low, filiform corrosion is initiated in the early stage. The filiform corrosion grows in random directions, forming a network of ridges. White nodules nucleate and grow on the ridges during continued corrosion and eventually connect with each other to form the initial corrosion scale. Pits were also found on the surface beneath corrosion products. In the case of a natural atmospheric environment, both filiform corrosion and other localized corrosion, such as pitting and inter-granular attack take place in the initial stage. It is obvious that there is variety of localized corrosion in the initial stage of atmospheric corrosion

  9. Report of a minor 125I exposure in a research laboratory

    In routine thyroid scanning of personnel whose work involved the use of 125I in biological research, it was discovered that an individual who had been iodinating proteins periodically for over 6 months showed a high thyroid count rate. It was decided to monitor the individual's thyroid weekly and to curtail his work in the laboratory until the cause of the thyroid uptake could be determined. Initially the 125I concentration in his thyroid decreased as expected but a subsequent scan on the 21st day showed an 125I concentration even greater than the initial level despite his absence from the laboratory. However on monitoring his office space, it was discovered that a felt pen was grossly contaminated and that the individual habitually put the pen in his mouth during moments of cogitation. It was concluded that a contaminated glove had transferred some 125I to the pen during the course of the experiment. (U.K.)

  10. Whole-body heat exposure induces membrane changes in spermatozoa from the cauda epididymidis of laboratory mice.

    Wechalekar, Harsha; Setchell, Brian P; Peirce, Eleanor J; Ricci, Mario; Leigh, Chris; Breed, William G

    2010-07-01

    This study was carried out to determine if exposure to hot environmental temperatures had a direct, detrimental effect on sperm quality. For this the effect of whole-body heat exposure on epididymal spermatozoa of laboratory mice was investigated. C57BL/6 mice (n = 7) were housed in a microclimate chamber at 37 degrees C-38 degrees C for 8 h per day for three consecutive days, while control mice (n = 7) were kept at 23 degrees C-24 degrees C. Cauda epididymal spermatozoa were obtained 16 h after the last heat treatment. The results showed that sperm numbers were similar in the two groups (P = 0.23), but after heat treatment, a significant reduction in the percentage of motile sperm was present (P phosphotidylserine from the inner to the outer leaflet of the sperm plasma membrane, and 7-aminoactinomycin D (7-AAD), which binds to the sperm nucleus when the plasma membrane is damaged. The percentage of spermatozoa showing positive staining with Annexin V-PE or 7-AAD or both, was significantly higher (P < 0.05) in heat-exposed mice compared with controls. These results show that whole-body heat exposure to 37 degrees C-38 degrees C induces membrane changes in the epididymal spermatozoa of mice, which may lead to apoptosis. PMID:20531278

  11. Lung nodules accidentally detected on CT scans

    Improving of the spatial resolution of modern CT scanners has increased the amount of information obtained by lung CT, and thus the amount of accidentally determined nodules and quality of their structure specification. To unify the criteria of their follow-up CT studies Fleischner Society has issued recommendations for management of solid pulmonary nodules, and then added recommendations for subsolid nodules. In this article the review of categories of such accidental findings in lungs is presented with follow-up criteria and annotations applied

  12. Tuberculosis cutánea por inoculación accidental Cutaneous tuberculosis accidental inoculation

    María Ascensión Maestre Naranjo; Jenry Borda Olivas; Arantxa Ortega Hernández; Esmeralda Tovar Benito; María Luisa Rodríguez de la Pinta; Rosa María Daza Pérez

    2009-01-01

    Caso clínico de una microbióloga con amplia experiencia, que sufre una inoculación accidental al manipular una cepa pura de Mycobacterium tuberculosis. Se pincha en la cara lateral externa de la falange distal del dedo índice, atravesando el guante con la aguja contaminada. (Imagen 1). La trabajadora procede de forma inmediata a la limpieza de la herida. El Servicio de Prevención, registra la inoculación como accidente de trabajo. A las tres semanas del accidente, aparece en el lugar de la in...

  13. Doctrinal elements for the post-accidental management of a nuclear accident - Final version

    This report examines and defines the objectives, principles and main actions for the post-accidental management of a nuclear accident. It defines the emergency phase and the post-accidental phase, three basic objectives (to protect the population against the hazards of ionizing radiations, to support populations affected by the accident consequences, to restore affected territories), management principles, key issues for post-accidental management. It defines actions to be undertaken: post-accidental zoning, monitoring of deposited radioactivity, early actions for the protection and taking charge of population, information. It addresses the different aspects of post-accidental management planning in a period of transition: reception of population, reduction of population exposure to deposited radioactivity, treatment of public health problems, improvement of the knowledge on the radiological situation of the environment, improvement of the radiological quality of the different environments, dealing with wastes, empowerment of stakeholders through an adequate governance, support and redeployment of economic activity, help and compensation, information. Appendices more deeply discuss actions to be undertaken just after the emergency phase, for the management of the transition period, and for the management of the long-term period

  14. Exposure levels to radiation in a nuclear medicine laboratory: measurements with thermoluminescence dosemeters

    Since 1996 in the Nuclear medicine Department and another routine and research departments of the National Institute of Medical and Nutrition Sciences (INCMNSZ) are working at least with 12 radioactive sources opened and sealed. However, it was unknown if with the Tl personal dosemeters with lithium fluoride crystals (LiF), could be possible to receive information about the equivalent dose for each radionuclide or if there was some radionuclide that by being low energy emissor or beta energy emissor, it did not represent an ionization power sufficient to excite the crystals of the thermoluminescent dosemeters (DTL). In this work the obtained results with control dosemeters of diverse source opened or sealed are shown, which were put at 1 cm of the LiF crystals during a time exposure 18 hours. Therefore the objective of this work is to verify which sources excite or not to DTL crystals and taking the pertinent safety measures for each radionuclide. The conclusion is that the majority of dosemeters were excited by beta or gamma radiation of the radionuclides and that LiF crystals are able to receive equivalent doses until 1200 mSv, being this a guarantee for the staff, that in an any moment could be exposed to high dose in his working day. Also it was corroborated that the radionuclides more energizer are: iodine-131, iodine-125 and sodium-22 while the phosphorus-32 must be managed with careful, since the exposure to hands can result significant, just like the technetium-99m (99m Tc). (Author)

  15. Medical handling of accidentally exposed individuals: recommendations

    The manual Medical Handling of Accidentally Exposed Individual, IAEA Safety Series no. 88 has been translated to portuguese language. Additional considerations about the Goiania radiological accident were incorporated to the original text, which provides knowledge involving health problems to both workers and public members. Also information concerning blood, recent radiological accidents, recommended maximum limited doses and a glossary were introduced. 5 refs

  16. Accidental fire in the West Hall

    1977-01-01

    On January 7 an accidental fire due to the failure of standard circuit-breakers, destroyed the coils of two spectrometer magnets and severely damaged the apparatus of two experiments. See also photos 7701582X, 7701581X, 7701580X. (Annual Report 1977, pg. 127-128)

  17. Report of an accidental exposure of patients in radiation therapy

    Full text. Accident with radiation therapy patients, when they happen, have a high probability of being very severe. This paper reports an accident that occurred last November in Brazil involving several patients submitted to therapy with clinical electron beams from 6 to 12 MeV. A field response team from the Instituto de Radioprotecao e Dosimetria (IRD), and the Laboratorio de Ciencias Radiologicas (LCR/DBB/UERJ), was sent to identify the causes of the accident and evaluate its consequences. The report suggests several actions to be observed by regulatory authorities, licensees and several other legal persons and individuals with subsidiary responsibilities. Evaluation of radiologic accidents is important because it permits to introduce the lessons learned in the radiation protection system, including design of equipment and installations, radiation procedures and personnel qualification and because it renders and attitude of continuous alert so a non usual event will not run into an accident. The accident A 'flat/sym'interlock problem occurred with the electron beam of a Mevatron-74 linear accelerator. After consulting the physicist, the technicians operated the equipment on the 'research mode' (non-clinical). Later the physicist came to verify the equipment and noticed that the dose rate presented high oscillation and that the 'pgm/norm'key was set to 'pgm'. After setting the control to 'norm'the equipment resumed working and some patients were treated in clinical mode and some in research mode. The machine then stops working and the service personnel were called. On 11/28 the maintenance technician fixed the equipment and the physicist measured the dose rate under 'pgm'mode and notice that it was about eight times over the normal value. COnclusion: the working group concluded that the accident could happen only if the equipment were operated on non-clinical mode. It can be summarized as : The event initiator: the flat/sym interlock. The accident promoter: the equipment was operated on non-clinical mode. A non-usual event was the 'pgm/norm' key that was set wrongly to 'pgm' contributed to the fate. The extent: during the accident the electron beams corresponded in intensity and energy to those used to photon generation. The dosimetry reconstitution showed doses 8 to 9 times over the prescription. A patient was treated on 11/26 and eight on 11/27 on research mode with dose ranging from 1400 to 2000 cGy, depending on the prescription. The patients presented dry and/or humid scamation with further clinical regression

  18. A mathematical model for predicting the probability of acute mortality in a human population exposed to accidentally released airborne radionuclides. Final report for Phase I of the project: early effects of inhaled radionuclides

    The report presents a mathematical model for the purpose of predicting the fraction of human population which would die within 1 year of an accidental exposure to airborne radionuclides. The model is based on data from laboratory experiments with rats, dogs and baboons, and from human epidemiological data. Doses from external, whole-body irradiation and from inhaled, alpha- and beta-emitting radionuclides are calculated for several organs. The probabilities of death from radiation pneumonitis and from bone marrow irradiation are predicted from doses accumulated within 30 days of exposure to the radioactive aerosol. The model is compared with existing similar models under hypothetical exposure conditions. Suggestions for further experiments with inhaled radionuclides are included

  19. Interest of stable iodine prophylaxis in accidental situation

    In the case of an accident on a nuclear reactor, radioactive substances could be released in atmosphere. among these substances, the presence of radioactive isotopes of iodine is a constant, that, in the lack of efficient counter measures could lead to an internal contamination, principally by inhalation but also by contaminated food ingestion. The radioactive iodine accumulate in the thyroid, leading to an exposure that at term can induce an increase of a cancer risk for this gland among the most sensitive persons, especially the children. It exists a simple and efficient protection mean: the taking of a tablet of stable iodine. In this article, the interest of the prophylaxis by stable iodine in accidental situation is tackled under the shape of eleven independent questions/answers, allowing a reading in several times but also the research of response elements to a question that the reader could wonder. (N.C.)

  20. Anaphylaxis after accidental ingestion of kiwi fruit

    Gawrońska-Ukleja, Ewa; Różalska, Anna; Ukleja-Sokołowska, Natalia; Żbikowska-Gotz, Magdalena; Bartuzi, Zbigniew

    2013-01-01

    Numerous cases of anaphylaxis after ingestion of kiwi fruit, after the skin tests and during oral immunotherapy were described. The article describes the case of severe anaphylactic reaction that occurred in a 55-year-old patient after accidental ingestion of kiwi. Allergy to kiwi fruit was confirmed by a native test with fresh kiwi fruit. After the test, the patient experienced generalized organ response in the form of headache, general weakness and rashes on the neck and breast, and dyspnea...

  1. Accidental swallowing of orthodontic expansion appliance key.

    Monini, André da Costa; Maia, Luiz Guilherme Martins; Jacob, Helder Baldi; Gandini, Luiz Gonzaga

    2011-08-01

    Ingestion of a foreign object, including a dental object, can lead to a trip to the emergency room. This article describes the accidental swallowing of a key that was used to activate a rapid maxillary expander. An orthodontic patient swallowed the key while trying to activate the appliance at home. The object's trajectory was followed on radiographs until it was eliminated. Possible clinical complications, legal implications of this situation, and practices for prevention are described. PMID:21803265

  2. Demonstration of the astral post accidental code

    Full text: Should an important release of radionuclides occur in the environment, one would quickly have to assess radionuclide concentration in media and foodstuff, deduce the potential exposition of concerned populations to the radiations, predict the evolution of the situation and propose different scenarios of managing the contaminated zones. To achieve this, the ASTRAL code was created, which can be used by a relatively large group of people composing crisis centers or making predictive impact studies. The starting point of the assessments is the ground deposit of radionuclides: the atmospheric dispersion phase and the cloud exposure are not taken into account here. The calculations achieved concern time evolution of radionuclide concentration in elements of the agricultural and forest food chain as well as assessment of doses due to external and internal exposure. These values are compared to regulation limits and/or intervention levels. Different simulations of contaminated zones management can be led by applying counter-measures, dispositions meant to reduce the accident's impact an environment and populations. The seventy radionuclides taken into account in the present version are some of those met in case of accidents or during the exploitation of a Pressurized Water Reactor (PWR). They relates to 37 elements that are : Ag, Am, Ba, Br, Cd, Ce, Cl, Cm, Co, Cr, Cs, Eu, Fe, I, Ir, La, Mn, Mo, Nb, Nd, Ni, Np, Pm, Pr, Rb, Rh, Ru, Sb, Sm, Sn, Sr, Tc, Te, Y, Zn, Zr. On a temporal point of view, the predictions extend to 3 years after the deposition. The starting point of calculations, deposits on the ground, can be issued from field measurements or predicted by a code - especially in an early phase when deposits are expected but have not occurred. Such predictions are performed by CONRAD, the atmospheric dispersion tool developed by IRSN for its Crisis Technical Center. A link in ASTRAL has been developed to fetch CONRAD's results and Input them in its database

  3. Accidental Kähler moduli inflation

    We study a model of accidental inflation in type IIB string theory where inflation occurs near the inflection point of a small Kähler modulus. A racetrack structure helps to alleviate the known concern that string-loop corrections may spoil Kähler Moduli Inflation unless having a significant suppression via the string coupling or a special brane setup. Also, the hierarchy of gauge group ranks required for the separation between moduli stabilization and inflationary dynamics is relaxed. The relaxation becomes more significant when we use the recently proposed D-term generated racetrack model

  4. Learning From Biomarkers in Victims Accidentally Exposed to Ionizing Radiation

    Yan Wang; Liqing Du; Chang Xu; Qin Wang; Zhiyi Song; Jianxiang Liu; Xu Su

    2016-01-01

    Biomarkers,such as chromosome aberration and micronuclei assays,prove to be reliable for facilitating clinical diagnosis in radiation accidents.In a radiation accident in India,chromosomal aberration,γ-H2AX,as well as other blood markers,were detected in accidentally exposed victims.This multi-parametric approach aided in confirming that individuals had been exposed by ionizing radiation.However,doses were impossible to estimate because of a 30-day delay in accident awareness.Exposure dose for victims was estimated using a dose-response curve previously established.Dose estimation,blood cell depletion kinetics,and no appearance of prodromal symptoms suggested that doses of exposure were low.Hematologic investigation,sampling time,and chromosome aberration scoring were all proposed according to data from the victims exposed to 60Co.Finally,knowledge regarding chromosome aberration analysis and the importance of international co-operation and assistance should be shared from this accident.

  5. Performance test of a portable TLD system for accidental doses

    Full text: A portable TLD measuring system was constructed at the J. Stefan Institute many years ago, motivated by the thread of a catastrophic nuclear event. It was designed for fast measurements in accidental dosimetry mainly for military and civil protection use. The system consists of a robust portable measuring unit built for measurements in field conditions, sized about 40 cm in diameter and weighting 5 kg. Dosimeters are based on CaF2:Mn ceramic tablets closed in water resistant plastic housings. In original design producer assured measuring range from cGy to kGy. Specially designed energy compensating filters are used to satisfy requirements for energy response from 0,1 to 3 MeV. Stability of readings is maintained with the temperature stabilized light source. Measuring time for manually driven heating-reading cycle of one dosimeter is about 30 sec. Many systems of the type with sets of dosimeters were stored unused for some years in depositories of different institutions. Modernization of equipment in last years raised questions of applicability of such measurement systems for contemporary needs. The system was thus tested in a secondary standards dosimetry laboratory for compliance with up to date requirements for accidental individual monitoring. Dosimeter characteristics as repeatability, linearity and directional response were of particular interest. As a result of the tests, technical improvements are suggested to extent systems measuring capabilities in order to meet new standards. Possibilities of its use in different fields of dosimetry are discussed, where quick in field measurements of high doses is required as for example in medicine or in civil protection motivated by the new threads of terrorist attacks. (author)

  6. Accidentes de tránsito terrestre

    José Enrique Ramírez Muñoz

    2013-09-01

    Full Text Available Los accidentes de tránsito terrestres en Costa Rica se han convertido en un serio problema de salud pública, que derivan ya sea en lesiones graves o bien en muertes de personas de todas las edades. Estos eventos incluyen el atropellamiento, las colisiones y choques, y producen cuadros lesionológicos muy diversos de acuerdo a la participación de las personas, el tipo de vehículo y la forma en la que se produce el traumatismo. Así mismo, se debe tener en cuenta la participación de factores coadyuvantes como el uso del casco y el cinturón de seguridad, o bien el consumo de alcohol y el uso del teléfono móvil. La valoración médico legal de las víctimas, vivas o muertas de accidentes de tránsito, está a cargo del Departamento de Medicina Legal del Organismo de Investigación Judicial, y se hace por solicitud de una Autoridad Judicial competente.

  7. Accidental gamma dose measurement using commercial glasses.

    Narayan, Pradeep; Vaijapurkar, S G; Senwar, K R; Kumar, D; Bhatnagar, P K

    2008-01-01

    Commercial glasses have been investigated for their application in accidental gamma dose measurement using Thermoluminescent (TL) techniques. Some of the glasses have been found to be sensitive enough that they can be used as TL dating material in radiological accident situation for gamma dosimetry with lower detection limit 1 Gy (the dose significant for the onset of deterministic biological effects). The glasses behave linearly in the dose range 1-25 Gy with measurement uncertainty +/- 10%. The errors in accidental dose measurements using TL technique are estimated to be within +/- 25%. These glasses have shown TL fading in the range of 10-20% in 24 h after irradiation under room conditions; thereafter the fading becomes slower and reaches upto 50% in 15 d. TL fading of gamma-irradiated glasses follows exponential decay pattern, therefore dosimetry even after years is possible. These types of glasses can also be used as lethal dose indicator (3-4 Gy) using TL techniques, which can give valuable inputs to the medical professional for better management of radiation victims. The glasses are easy to use and do not require lengthy sample preparation before reading as in case of other building materials. TL measurement on glasses may give immediate estimation of the doses, which can help in medical triage of the radiation-exposed public. PMID:18285317

  8. Management options in the food chain for accidental radionuclide deposition

    Finland with four other countries participated in the European Union's network project FARMING in 2000 - 2004. The aim of the project was to invite participants from each country representing the food supply chain in a stakeholder group and advance with the groups the networking in building preparedness for accidental contamination of the food production systems. The task of the groups was to evaluate the practicability of management options suggested for reduction of radiation exposure through foodstuffs, and for disposal of waste generated in implementation of these options. The criteria for practicability were effectiveness in reduction of radiation exposure through foodstuffs, technical feasibility, capacity, costs for implementation, secondary costs for waste disposal, socio-economic impact, and acceptability concerning ecology and protection of environment and landscape. Practicable management options aimed at sustainable restoration of food production systems after accidental contamination. The Finnish stakeholder group represented farm production, processing industry, food marketing, catering, advisor organisations for households and agriculture, consumers, nature conservation, the media, experts on environmental impact and authorities responsible for production, safety and security of foodstuffs, food supply and feedstuffs. The group was expected to examine the effect of the Finnish, and, also more generally, northern production conditions on the practicability of the suggested management options. The stakeholder group members first familiarized themselves with intervention after accidental contamination of a large milk production area and thereafter with practicability of individual management options. The evaluation was based on the group members' complementary expertise that very well covered the chain 'from field to fork' whether the issue was related to legislation, production methods, logistics, environmental impacts, or the issues of consumers and

  9. Accidental etizolam ingestion in a child.

    Kato, Zenichiro; Nakamura, Mitsuhiro; Funato, Michinori; Kuwabara, Hideaki; Kondo, Naomi

    2007-07-01

    Etizolam (ETZ) is an antidepressive thienodiazepine drug that is used worldwide. The most frequent adverse effects in adults are drowsiness and muscle weakness, and this can rarely cause paradoxical excitation; however, no information exists on intoxication in children. Furthermore, evidence bearing on its safety in children is not available. We present a case of a child who accidentally took a single dose of ETZ, approximately the same as a therapeutic dose for adults, and who showed paradoxical excitation and muscle weakness. The case presented here suggests that pediatricians and emergency physicians should be aware of the possible adverse effects in children and therapeutic approaches in intoxication of ETZ and the necessity of further investigations on a specific therapeutic guideline for overdose management especially in children. PMID:17666930

  10. Throat-cutting of accidental origin.

    Demirci, Serafettin; Dogan, Kamil Hakan; Gunaydin, Gursel

    2008-07-01

    Incised wounds of the neck can be accidental, homicidal, or suicidal. In this paper, a death case has been presented where a spinning circular saw of a cutting machine in a workshop came off its place and cut the throat of a 30-year-old male who was operating the machine. There was an incision (15 cm x 5 cm) that began in the middle of the neck down the thyroid cartilage, extended horizontally to the left of the neck and ended on the outer part of the neck in the outer left side of m. trapezius. Death occurred because of exsanguination caused by the cutting of carotis artery and jugular vein. In the case we presented, although the cut in the neck initially suggested homicide, it was found to have occurred as a result of an accident after the autopsy and death scene investigation. PMID:18489556

  11. Accidental foreign bodies in pediatric abdomens: A pictorial essay

    Foreign bodies in pediatric abdomens are caused by accidental ingestion or trauma. The purpose of this article is to review the various findings of accidental foreign bodies in pediatric abdomens. Abdominal radiography, fluoroscopic examination, gastrointestinal contrast studies and CT may be useful in evaluating the location and type of foreign body, and for evaluating complications such as bowel perforation and obstruction

  12. Accidental foreign bodies in pediatric abdomens: A pictorial essay

    Park, Chan Ho; Kim, Young Tong [Soonchunhyang Univ. Cheonan Hospital/Soonchunhyang Univ. College of Medicine, Cheonan (Korea, Republic of)

    2012-08-15

    Foreign bodies in pediatric abdomens are caused by accidental ingestion or trauma. The purpose of this article is to review the various findings of accidental foreign bodies in pediatric abdomens. Abdominal radiography, fluoroscopic examination, gastrointestinal contrast studies and CT may be useful in evaluating the location and type of foreign body, and for evaluating complications such as bowel perforation and obstruction.

  13. Detecting the exposure to Cd and PCBs by means of a non-invasive transcriptomic approach in laboratory and wild contaminated European eels (Anguilla anguilla).

    Baillon, Lucie; Pierron, Fabien; Oses, Jennifer; Pannetier, Pauline; Normandeau, Eric; Couture, Patrice; Labadie, Pierre; Budzinski, Hélène; Lambert, Patrick; Bernatchez, Louis; Baudrimont, Magalie

    2016-03-01

    Detecting and separating specific effects of contaminants in a multi-stress field context remain a major challenge in ecotoxicology. In this context, the aim of this study was to assess the usefulness of a non-invasive transcriptomic method, by means of a complementary DNA (cDNA) microarray comprising 1000 candidate genes, on caudal fin clips. Fin gene transcription patterns of European eels (Anguilla anguilla) exposed in the laboratory to cadmium (Cd) or a polychloro-biphenyl (PCBs) mixture but also of wild eels from three sampling sites with differing contamination levels were compared to test whether fin clips may be used to detect and discriminate the exposure to these contaminants. Also, transcriptomic profiles from the liver and caudal fin of eels experimentally exposed to Cd were compared to assess the detection sensitivity of the fin transcriptomic response. A similar number of genes were differentially transcribed in the fin and liver in response to Cd exposure, highlighting the detection sensitivity of fin clips. Moreover, distinct fin transcription profiles were observed in response to Cd or PCB exposure. Finally, the transcription profiles of eels from the most contaminated site clustered with those from laboratory-exposed fish. This study thus highlights the applicability and usefulness of performing gene transcription assays on non-invasive tissue sampling in order to detect the in situ exposure to Cd and PCBs in fish. PMID:26566612

  14. Accumulation of copper, chromium, and arsenic in blue mussels (Mytilus edulis) from laboratory and field exposures to wood treated with chromated copper arsenate type C

    Adler-Ivanbrook, L.; Breslin, V.T. [State Univ. of New York, Stony Brook, NY (United States)

    1999-02-01

    Laboratory and field experiments were conducted to examine the uptake of Cu, Cr, and As leached from southern yellow pine (SYP) treated with chromated copper arsenate type C (CCA-C), as well as effects on mortality and growth, in blue mussels (Mytilus edulis). Mussels were exposed to CCA-C-treated wood at a preservative retention of 40 kg/m{sup 3} and control (nontreated) SYP in laboratory flow-through sea table and field exposure experiments for 9 months in 1994 and 3 months in 1995. Mussels were sampled at regular intervals to evaluate possible short- and long-term exposure effects., Individual mussels were measured to determine the length, dry weight, and condition index. Mussel tissues were than analyzed for Cu, Cr, and As. Results showed few significant differences in condition index, dry weight, and length between CCA-C-exposed and control mussels. In addition, no statistically significant differences in mortality were found between the mussels exposed to CCA-C-treated and nontreated SYP in the laboratory flow-through sea table and field exposure experiments. Significant differences in Cu, As, and Cr contents in mussel tissues between treatments were few, and generally cannot be attributed to exposure to CCA-C-treated SYP. The lack of Cu, Cr, and As uptake from CCA-C-treated SYP was attributed to the low, although continuous, rate of release of these elements from CCA-C-treated wood and to the experimental design, which allowed continuous flushing, prohibiting the accumulation of these elements in the water surrounding the mussels.

  15. CRADA with Teledyne Electronic Technologies and Pacific Northwest National Laboratory (PNL-096): The Exposure-to-Risk monitoring system. Final letter report

    Thrall, K.D.

    1996-10-01

    The purpose of this project was to demonstrate the ``Exposure-to- Risk`` monitoring system in an actual occupational environment. The system is a unique combination of existing hardware with proprietary software to create an integrated means of assessing occupational exposures to volatile organic compounds. One component of this system utilizes a portable mass spectrometer developed by Teledyne Electronic Technologies. Integration of the system was accomplished under Laboratory Directed Research and Development (LDRD) funding. Commercialization of the system will take place following demonstration in an actual occupational environment, and will include, in part, Teledyne Electronic Technologies. The Exposure-to-Risk monitoring system will benefit DOE by overcoming present-day limitations in worker health protection monitoring. There are numerous sites within the` DOE complex where many different hazardous chemicals are used on a routine basis. These chemicals range from paint stripers and cleaning solvents to chemical warfare agents, each having its own degree of potential adverse health risk to a worker. Thus, a real concern for DOE is to ensure that a worker is properly monitored to assess any adverse health risk from exposure to potentially hazardous chemicals. With current industrial hygiene technologies, this is an arduous task. The Exposure-to-Risk monitoring system integrates a patented breath-inlet device connecting a subject`s exhaled breath directly with a field-portable mass spectrometer with physiologically based pharmacokinetic (PBPK) modeling to estimate the target tissue dose following a chemical exposure. Estimation of the adverse health risk prediction follows from the exposure/dose calculation based on currently accepted methodologies. This new system can determine, in the field, the possible adverse health risks on a daily basis to an individual worker.

  16. Kinematics and kinetics of an accidental lateral ankle sprain.

    Kristianslund, Eirik; Bahr, Roald; Krosshaug, Tron

    2011-09-23

    Ankle sprains are common during sporting activities and can have serious consequences. Understanding of injury mechanisms is essential to prevent injuries, but only two previous studies have provided detailed descriptions of the kinematics of lateral ankle sprains and measures of kinetics are missing. In the present study a female handball player accidentally sprained her ankle during sidestep cutting in a motion analysis laboratory. Kinematics and kinetics were calculated from 240 Hz recordings with a full-body marker setup. The injury trial was compared with two previous (non-injury) trials. The injury trial showed a sudden increase in inversion and internal rotation that peaked between 130 and 180 ms after initial contact. We observed an attempted unloading of the foot from 80 ms after initial contact. As the inversion and internal rotation progressed, the loads were likely to exceed injury threshold between 130 and 180 ms. There was a considerable amount of dorsiflexion in the injury trial compared to neutral flexion in the control trials, similar to the previously published kinematical descriptions of lateral ankle sprains. The present study also adds valuable kinetic information that improves understanding of the injury mechanism. PMID:21824618

  17. Evaluation of post-accidental rehabilitation strategies

    Post-accidental management aims at restoring acceptable life conditions for population on sanitary, social and economic aspects. It is then a matter for an optimisation process in a multicriteria context, which has to combine quantitative parameters as well as qualitative parameters. In order to fit with this problematic a methodological work has been realised at IPSN. The methodology consists in making a systematic evaluation of indicators in order to provide intercomparing data for many rehabilitation strategies. It relies on four steps: characterisation and formalization of the geographic and demographic environment, radiological diagnosis, selection of countermeasures from a well characterised set of techniques, and last, evaluation of the intercomparing factors. The methodology has been applied to the Becquerel national exercise. Rejects were limited and the contaminated area was less than 2000ha. Conclusions proposed depend on this context. For the selected countermeasures, radiological benefit and some incidences have been calculated: duration of realisation of the counter-measure, materials and human means, worker doses, and amount of generated wastes. In this context, calculations highlighted the importance of external exposition in built areas from the first year after the accident, for most of the reference groups. Ingestion is important only the first year for the highly autarkical level reference groups. Consequently, countermeasures applied to built areas, such as washing of sidewalks, of streets and roofs, or such as trees pruning ,are the most effective for the dosimetric criteria. In agricultural zone, taking off vegetation and ploughing enable to strongly reduce specific activity on food products. Reduction by soil removal is more effective. But here, management problems due to the large amount of generated waste could discard this kind techniques. Countermeasures on milk applied the first year reduce by 3 the dose for highly autarkical level

  18. Caesium-137 Chloride Retention following Accidental Ingestion

    Four men became contaminated with caesium-137 chloride due to leaks in a 100 c source. The source was believed to be completely leak proof, since the caesium chloride was contained in a welded stainless-steel capsule which was covered with an outer steel jacket of standard Oak Ridge design. Most of the contamination occurred while the men were cleaning the components of a pneumatic device used to move the source. The most heavily- contaminated individual placed his mouth over the end of a transport tube and attempted to blow some ''dust'' out of the tube. The other men handled various parts of the transport mechanism and wiped ''dust'' out of holes with their fingers. None of the men washed their hands before eating lunch. When radioactive contamination was discovered on the following day, immediate efforts were made to decontaminate the men. Arrangements for whole-body counts were also made and, on the fifth day following contamination, the men reported to the Radiation Exposure Evaluation laboratory. The body burdens on the fifth day ranged from 35 - 970 nc of caesium-137. During the next five to six days the burdens dropped rapidly and on the eleventh day ranged from 28- 780 nc. After the eleventh day the body burdens of caesium-137 changed much more slowly. Whole-body counts made between the 11th and 160th day yielded biological half-lives of 76, 95 and 126 d for the three most heavily-contaminated individuals. During the period of rapid excretion all urine and faeces were collected and counted. These counts indicated a considerable superficial contamination prior to the eleventh day since only a portion of the removed caesium-137 was found in the urine and stool specimens. The body burdens of the four men are compared with normals of the same size, build, age and diet habits. A short discussion of normal burdens is included. A brief description of the counting system, data handling techniques and calibration procedures is also included. (author)

  19. Study of TSL and OSL properties of dental ceramics for accidental dosimetry applications

    Interest is increasing in the development of new methodologies for accidental dose assessment, exploiting the luminescence and dosimetric properties of objects and materials which can be usually found directly on exposed subjects and/or in the contaminated area. In this work, several types of ceramics employed for dental prosthetics restoration, including both innovative materials used as sub-frames for the construction of the inner part of dental crowns (core), and conventional porcelains used for the fabrication of the external layer (veneer), were investigated with regard to their thermally and optically stimulated luminescence (TSL and OSL respectively) properties, in view of their potential application in accidental dosimetry. The sensitivity to ionizing radiation proved to strongly depend on the type and brand of ceramic, with minimum detectable dose ranging from few mGy up to several tens of mGy. A linear dose-response was observed for most of the samples. However, the luminescence signals were characterised by a significant fading, which has to be taken into account for a reliable accidental dose assessment after a radiation exposure event.

  20. El accidente de trabajo. Concepto legal y jurisprudencia

    García Romero, José Daniel

    2015-01-01

    El trabajo final de grado versa sobre el concepto de accidente de trabajo que da la jurisprudencia a través de las diferentes sentencias del Tribunal Supremo en la Sala de lo Social, y de los diferentes Tribunales Superiores de Justicia. Analizaremos en profundidad que características tienen que concurrir para que sea considerado como tal, analizando los diferentes supuestos de accidente de trabajo como el accidente in itinere, en misión, etc. También hemos tratado las diferentes contingencia...

  1. Static and mobile networks design for atmospheric accidental releases monitoring

    The global context of my PhD thesis work is the optimization of air pollution monitoring networks, but more specifically it concerns the monitoring of accidental releases of radionuclides in air. The optimization problem of air quality measuring networks has been addresses in the literature. However, it has not been addresses in the context of surveillance of accidental atmospheric releases. The first part of my thesis addresses the optimization of a permanent network of monitoring of radioactive aerosols in the air, covering France. The second part concerns the problem of targeting of observations in case of an accidental release of radionuclides from a nuclear plant. (author)

  2. Reduction of exposure to acrylamide: achievements, potential of optimization, and problems encountered from the perspectives of a Swiss enforcement laboratory.

    Grob, Koni

    2005-01-01

    The most important initiatives taken in Switzerland to reduce exposure of consumers to acrylamide are the separate sale of potatoes low in reducing sugars for roasting and frying, the optimization of the raw material and preparation of french fries, and campaigns to implement suitable preparation methods in the gastronomy and homes. Industry works on improving a range of other products. Although these measures can reduce high exposures by some 80%, they have little effect on the background exposure resulting from coffee, bread, and numerous other products for which no substantial improvement is in sight. At this stage, improvements should be achieved by supporting voluntary activity rather than legal limits. Committed and consistent risk communication is key, and the support of improvements presupposes innovative approaches. PMID:15759749

  3. Miasis genital accidental por Eristalis tenax Accidental genital myiasis by Eristalis tenax

    Mauricio González M; Greissy Comte M; Javiera Monárdez P; Marcelo Díaz de Valdés L; Iván Matamala C

    2009-01-01

    Las miasis son infestaciones parasitarias de humanos o animales por larvas de mosca que infestan piel, tejidos necróticos y cavidades naturales. Presentamos el caso de una mujer de 27 años, asintomática, que eliminó espontáneamente por vía vaginal larvas de Eristalis tenax, una especie de mosca ampliamente distribuida en el mundo, la que es clasificada como agente de miasis accidental. La paciente residía en un área urbana de nivel socioeconómico bajo y entregaba como antecedente el uso de ve...

  4. Accidental releases of radionuclides: a preliminary study of the consequences of land contamination

    The long term consequences of land contamination from accidental releases of activity from thermal reactors are examined. The radiological consequences are assessed using an analysis of the exposure of individuals and the population to ground deposits of the radionuclides released. The contribution of the different nuclides in the release by their various exposure routes to the irradiation of man are calculated as a function of time after release and the most radiologically important are identified. A preliminary assessment is made of off-site economic and social consequences of accidental releases by estimating the areas of land which would be affected by the introduction of countermeasures to control individual radiation exposure due to external irradiation from ground deposits (relocation of populations), and the intake of radionuclides contained in locally produced foodstuffs (restrictions on food production). The areas where administrative controls would be necessary decline in size with time after the release; estimates are made of this time-dependent behaviour using dynamic environmental transfer models. Finally, the collective doses saved by the introduction of countermeasures are estimated using population and agricultural distribution data for a rural location in the United Kingdom. (author)

  5. Propofol-Induced Neurotoxicity in the Fetal Animal Brain and Developments in Modifying These Effects—An Updated Review of Propofol Fetal Exposure in Laboratory Animal Studies

    Ming Xiong

    2016-03-01

    Full Text Available In the past twenty years, evidence of neurotoxicity in the developing brain in animal studies from exposure to several general anesthetics has been accumulating. Propofol, a commonly used general anesthetic medication, administered during synaptogenesis, may trigger widespread apoptotic neurodegeneration in the developing brain and long-term neurobehavioral disturbances in both rodents and non-human primates. Despite the growing evidence of the potential neurotoxicity of different anesthetic agents in animal studies, there is no concrete evidence that humans may be similarly affected. However, given the growing evidence of the neurotoxic effects of anesthetics in laboratory studies, it is prudent to further investigate the mechanisms causing these effects and potential ways to mitigate them. Here, we review multiple studies that investigate the effects of in utero propofol exposure and the developmental agents that may modify these deleterious effects.

  6. The PROCESS experiment: exposure of amino acids in the EXPOSE-E experiment on the international space station and in laboratory simulations.

    Bertrand, M; Chabin, A; Brack, A; Cottin, H; Chaput, D; Westall, F

    2012-05-01

    To understand the chemical behavior of organic molecules in the space environment, amino acids and a dipeptide in pure form and embedded in meteorite powder were exposed in the PROCESS experiment in the EXPOSE-E facility mounted on the European Technology Exposure Facility (EuTEF) platform on board the International Space Station (ISS). After exposure to space conditions for 18 months, the samples were returned to Earth and analyzed in the laboratory for reactions caused by solar UV and cosmic radiation. Chemical degradation and possible racemization and oligomerization, the main reactions caused by photochemistry in the vacuum ultraviolet domain (VUV, wavelength range 100-200 nm for photon energy from 6.2 to 12.4 eV) were examined in particular. The molecules were extracted and derivatized by silylation and analyzed by gas chromatograph coupled to a mass spectrometer (GC-MS) to quantify the rate of the degradation of the compounds. Laboratory exposure in several wavelength ranges from UV to VUV was carried out in parallel in the Cologne Deutsches Zentrum für Luft- und Raumfahrt (DLR) Center and Centre de biophysique moléculaire (CBM) laboratories. The results show that resistance to irradiation is a function of the chemical nature of the exposed molecules and the wavelengths of the UV light. The most altered compounds were the dipeptide, aspartic acid, and aminobutyric acid. The most resistant were alanine, valine, glycine, and aminoisobutyric acid. Our results also demonstrate the protective effect of meteorite powder, which reemphasizes the importance of exogenic contribution to the inventory of prebiotic organics on early Earth. PMID:22680689

  7. Mistakes in diagnosing non-accidental injury: 10 years' experience

    Wheeler, David M; Hobbs, Christopher J

    1988-01-01

    Fifty children who were referred to the child abuse team in Leeds over the 10 years 1976-86 with suspected non-accidental injury were found to have conditions which mimicked non-accidental injury. These included impetigo (nine children) and blue spots (five children). Five children who presented with multiple bruising had haemostatic disorders. Eight children had disorders of the bone. Five children had been previously abused physically. Four showed evidence of neglect. One had evidence of no...

  8. Accidental Implant Screwdriver Ingestion: A Rare Complication during Implant Placement.

    Anshul Jain; Baliga, Shridhar D

    2014-01-01

    One of the complications during a routine dental implant placement is accidental ingestion of the implant instruments, which can happen when proper precautions are not taken. Appropriate radiographs should be taken to locate the correct position of foreign body; usually the foreign body passes asymptomatically from gastrointestinal tract but sometimes it may lead to intestinal obstruction, perforations and impactions. The aim of this article is to report accidental ingestion of 19 mm long scr...

  9. Accidental oil spills - project management strategy

    Planning and organisation, as well as actions taken during accidental discharging of hazardous substances (hydrocarbons) into the soil and water, show that without integrating all the functions of safety, occupational safety, fire and explosion protection, technical safety, all the way to the environmental protection, procedure of cleaning, rehabilitation and remediation of polluted areas into their original state cannot be successfully carried out. Neglecting any of the mentioned links/components of the procedure represents a risk to people's health and life, while pollution to the environment remains a constant threat. Development of technologies is quickly transforming the environment in which the professionals of all disciplines work. Therefore, the response to changes by application of new technologies and procedures in all domains is indispensable, however, through a comprehensive and expert perception and consideration of each of the essential correlations comprising the safety management in all the fields. Through management of safety projects in environmental protection, it has become obvious that a united management of different fields is necessary, as well as management of safety in general. Engineering, health, legislation, public, environmental standards, occupational safety, hazards, biophysical and socio-economic aspects are parts of an integral management. Experts joined efforts through interaction and communications are inter-disciplinary characteristics, i.e. multi-disciplinary safety management, but also the management of each project separately. Exactly this knowledge exchange is highly productive and becomes an indispensable element in recognition of indirect and cumulative actions, thus applicable in any field. Implementation of European standards and accreditation of procedures pursuant to the corresponding standards, from risk assessment through rehabilitation to independent expert confirmation of efficiency in implementing the entire

  10. Use of sulfur hexafluoride airflow studies to determine the appropriate number and placement of air monitors in an alpha inhalation exposure laboratory

    Determination of the appropriate number and placement of air monitors in the workplace is quite subjective and is generally one of the more difficult tasks in radiation protection. General guidance for determining the number and placement of air sampling and monitoring instruments has been provided by technical reports such as Mishima, J. These two documents and other published guidelines suggest that some insight into sampler placement can be obtained by conducting airflow studies involving the dilution and clearance of the relatively inert tracer gas sulfur hexafluoride (SF6) in sampler placement studies and describes the results of a study done within the ITRI alpha inhalation exposure laboratories. The objectives of the study were to document an appropriate method for conducting SF6 dispersion studies, and to confirm the appropriate number and placement of air monitors and air samplers within a typical ITRI inhalation exposure laboratory. The results of this study have become part of the technical bases for air sampling and monitoring in the test room

  11. Use of sulfur hexafluoride airflow studies to determine the appropriate number and placement of air monitors in an alpha inhalation exposure laboratory

    Newton, G.J.; Hoover, M.D.

    1995-12-01

    Determination of the appropriate number and placement of air monitors in the workplace is quite subjective and is generally one of the more difficult tasks in radiation protection. General guidance for determining the number and placement of air sampling and monitoring instruments has been provided by technical reports such as Mishima, J. These two documents and other published guidelines suggest that some insight into sampler placement can be obtained by conducting airflow studies involving the dilution and clearance of the relatively inert tracer gas sulfur hexafluoride (SF{sub 6}) in sampler placement studies and describes the results of a study done within the ITRI alpha inhalation exposure laboratories. The objectives of the study were to document an appropriate method for conducting SF{sub 6} dispersion studies, and to confirm the appropriate number and placement of air monitors and air samplers within a typical ITRI inhalation exposure laboratory. The results of this study have become part of the technical bases for air sampling and monitoring in the test room.

  12. [Severe accidental hypothermia in an elderly woman].

    Knobel, B; Mikhlin, A

    2001-11-01

    Profound hypothermia (core temperature of less than 28 degrees C) is a life threatening state and a medical emergency associated with a high mortality rate. The prognosis depends on underlying diseases, advanced or very early age, the duration prior to treatment, the degree of hemodynamic deterioration, and especially, the methods of treatment, including active external or internal rewarming. This is a case study of an 80-year-old female patient with severe accidental hypothermia (core temperature 27 degrees C). She was found in her home lying immobile on the cold floor after a fall. The patient was in a profound coma with cardiocirculatory collapse, and the medical staff treating her was inclined to pronounce her deceased. On her arrival at the hospital, she was resuscitated, put on a respirator and actively warmed. Very severe metabolic disorders were found, including a marked metabolic acidosis composed of diabetic ketoacidosis (she had suffered from insulin treated type 2 diabetes mellitus) and lactic acidosis with a very high anion gap (42) and a hyperosmotic state (blood glucose 1202 mg/dl). There were pathognomonic electrocardiographic abnormalities, J-wave of Osborn and prolonged repolarization. Slow atrial fibrillation with a ventricular response of 30 bpm followed by a nodal rhythm of 12 bpm and reversible cardiac arrest were recorded. The pulse and blood pressure were unobtainable. Despite the successful resuscitation and hemodynamic and cognitive improvement, rhabdomyolysis (CKP 6580 u/L), renal failure and hepatic damage developed. She was extubated and treated with intravenous fluids containing dopamine, bicarbonate, insulin and antibiotics. Her medical condition gradually improved, and she was discharged clear minded, functioning very well and independent. Renal and liver tests returned eventually to normal limits. Progressive bradycardia, hypotension and death due to ventricular fibrillation or asystole commonly occur during severe hypothermia

  13. Accidental Laser Injury to the Eye.

    Kandari, Jamal Al; Raizada, Seemant; Razzak, Ahmed Abdul

    2010-03-01

    The unprotected human eye is extremely sensitive to laser radiation and can be permanently damaged from direct or reflected beams. Two cases of retinal injury by laser exposure outside hospital setting are reported. Two patients presented in retina clinic in Al-Bahar eye center in Kuwait with complaints of decrease in vision following exposure to unknown light. Case 1 was exposed to a laser used in military warfare and Case 2 exposed to laser pointer. Routine slit lamp examination and fundus examination of the patient was done along with fundus fluorescien angiography (FFA) and Optical coherence tomography (OCT). Patients were followed up in out patient department for 6 months. Patient with military laser exposure had severe permanent vision loss and persisted even after 6 months. Patient exposed to laser pointer beam had transient visual loss, which improved to 20/25 at 7 months follow-up. Laser retinal damage should be suspected in any patient with visual complaints after obvious exposure to unknown strong light. The treatment for laser retinal injuries is extremely limited and hence prevention is essential. PMID:20337345

  14. The AMINO experiment: exposure of amino acids in the EXPOSE-R experiment on the International Space Station and in laboratory

    Bertrand, Marylène; Chabin, Annie; Colas, Cyril; Cadène, Martine; Chaput, Didier; Brack, Andre; Cottin, Herve

    2015-01-01

    In order to confirm the results of previous experiments concerning the chemical behaviour of organic molecules in the space environment, organic molecules (amino acids and a dipeptide) in pure form and embedded in meteorite powder were exposed in the AMINO experiment in the EXPOSE-R facility onboard the International Space Station. After exposure to space conditions for 24 months (2843 h of irradiation), the samples were returned to the Earth and analysed in the laboratory for reactions caused by solar ultraviolet (UV) and other electromagnetic radiation. Laboratory UV exposure was carried out in parallel in the Cologne DLR Center (Deutsches Zentrum für Luft und Raumfahrt). The molecules were extracted from the sample holder and then (1) derivatized by silylation and analysed by gas chromatography coupled to a mass spectrometer (GC-MS) in order to quantify the rate of degradation of the compounds and (2) analysed by high-resolution mass spectrometry (HRMS) in order to understand the chemical reactions that occurred. The GC-MS results confirm that resistance to irradiation is a function of the chemical nature of the exposed molecules and of the wavelengths of the UV light. They also confirm the protective effect of a coating of meteorite powder. The most altered compounds were the dipeptides and aspartic acid while the most robust were compounds with a hydrocarbon chain. The MS analyses document the products of reactions, such as decarboxylation and decarbonylation of aspartic acid, taking place after UV exposure. Given the universality of chemistry in space, our results have a broader implication for the fate of organic molecules that seeded the planets as soon as they became habitable as well as for the effects of UV radiation on exposed molecules at the surface of Mars, for example.

  15. Study of the luminescence properties of dental materials for their use in accidental dosimetry

    Full text: The current social and political situation in many world areas and the increasing hostilities between countries and cultures have accentuated the risk of a malicious use of ionising radiations. Terrorist attacks with the intentional disseminations of radioactive materials in urban settlements may involve a large number of persons, and a rapid estimation of the severity of the exposure is required for undertaking suitable protective actions and supporting decision making. Promising methodologies for a prompt dose evaluation, are those exploiting the luminescence and dosimetric properties of objects and materials which can be easily found in the contaminated area. Among these objects, dental materials have the advantage to be on contact with human body and they could therefore represent individual dosimeters in case of accidental exposure to ionising radiation. The interest in the use of dental ceramics for dosimetric purposes dates back to late 1970, however, it is only through the use of high-sensitive experimental techniques and instrumentation today available, that the potentiality of such materials as accidental dosimeters can be exploited. Moreover, innovative materials are being continuously introduced into the market, containing new additives and pigments with peculiar optical properties. In this study, Thermally Stimulated Luminescence (TSL) and Optically Stimulated Luminescence (OSL) techniques are applied to investigate the luminescence and dosimetric properties of several dental materials, including resins, glass and feldspatic ceramics, and also zirconia and alumina based ceramics, being their use widely increased in the recent years in substitution of metal cores. (author)

  16. [Effect of the exposure to factors inducing diffuse damage of cerebral tissue on sleep structure in laboratory rats].

    Koval'zon, V M; Dorokhov, V B; Loginov, V V

    2009-01-01

    Effects of strong stress inducing diffuse damage of the brain tissue on subsequent sleep were studied in rats preliminary implanted with chronic electrodes for the neocortical and hippocampal EEG as well as EMG of the neck muscles. An acute and three chronic experimental models were used: general cerebral ischemia induced by a permanent unilateral occlusion of the common carotid artery, hypoxic hypoxia, hypoglycemia, and "penicillinium" epilepsy. Polysomnographic recording was performed either continuously within 24 hrs (in case of the chronic stress model) or 3 hrs daily: from 09 to 12 a.m. (for three acute stress models). In all the models, a significant increase in the paradoxical sleep (PS) percentage was found which reached its maximum within 1-3 days since stress exposure. The following changes were found to be dependent upon the character of the stress factor. In acute stress models, the PS percentage returned to the baseline level within 5-6 days. In the chronic model, the PS percentage returned to baseline level on the 40-45th day after the day of occlusion. The sharp increase in the PS percentage following the exposure to stress factors inducing cerebral tissue damage corroborate the hypothesis of an increase in neural tissue restitution processes during PS periods. PMID:19445391

  17. Laboratory-acquired brucellosis

    Fabiansen, C.; Knudsen, J.D.; Lebech, A.M.

    2008-01-01

    Brucellosis is a rare disease in Denmark. We describe one case of laboratory-acquired brucellosis from an index patient to a laboratory technician following exposure to an infected blood culture in a clinical microbiology laboratory Udgivelsesdato: 2008/6/9......Brucellosis is a rare disease in Denmark. We describe one case of laboratory-acquired brucellosis from an index patient to a laboratory technician following exposure to an infected blood culture in a clinical microbiology laboratory Udgivelsesdato: 2008/6/9...

  18. Accidental carbon monoxide poisoning in our homes

    Sharma Shruti; Gupta Rahul; Paul Barinder; Puri Sandeep; Garg Shuchita

    2009-01-01

    Carbon monoxide (CO) is a colorless, odorless, tasteless, nonirritating, but significantly toxic gas. It is a product of combustion of organic matter in presence of insufficient oxygen supply. Symptoms of mild poisoning include headaches, vertigo and flu like effects, whereas larger exposures can lead to significant toxicity of the central nervous system (CNS), heart, and even death. We are reporting two cases that presented to us in the winter months of December to January with history, sign...

  19. Summary of accidental releases of radioactivity detected off the Nevada Test Site, 1963--1986

    Of the more than 450 underground nuclear explosives tests conducted at the Nevada Test Site from August 1963 (signing of the Limited Test Ban Treaty) through the end of 1986, only 23 accidentally released radioactivity that was detectable beyond the boundary of the NTS. Of these 23, 4 were detectable off the NTS only by aircraft while the remainder were detectable by ground monitoring instruments. Since the Baneberry venting of December 1970, only two tests released radioactivity that was detectable off the NTS, and this was a seepage of radioactive noble gases. None of these releases from underground tests designed for complete containment caused exposure of the population living in the area that exceeded standards recommended by national and international radiation protection agencies. This report summarizes the releases from each of the tests, describes the monitoring that was conducted, and lists the location of the maximum exposure

  20. The assessment of the radiological significance of accidental releases of radionuclides to coastal waters

    Methods are described which enable the radiological consequences of an accidental release of activity to an estuary or sea to be assessed, assuming the release is in the same physical and chemical form as routine discharges. Critical group and collective exposures are considered for the most important seafood ingestion and external radiation pathways. Detailed consideration is given to the interaction of activity with marine sediments, and this enables a more realistic description of any resulting radiation exposure to be given than is possible by using existing mathematical models more suited to extended releases of radionuclides. The methods employed constitute an interesting use of a powerful technique involving the numerical inversion of Laplace transformed quantities. (author)

  1. Causes of accidental childhood deaths in China in 2010

    Chan, Kit Yee; Yu, Xin-Wei; Lu, Jia-Peng;

    2015-01-01

    middle-income country (LMIC) settings. In this paper, we aim to establish cause structure for accidental deaths in children aged 0-4 years in China in the year 2010. METHODS: In this paper, we explored the database of 208 multi-cause child mortality studies in Chinese that formed a basis for the first...... deaths. We identified 71 further studies that provided specific causes for accidental deaths. We used epidemiological modeling to estimate the number of accidental child deaths in China in 2010 and to assign those deaths to specific causes. RESULTS: In 2010, we estimated 314 581 deaths in children 0......-4 years in China, of which 31 633 (10.1%) were accidental. Accidental deaths contributed 7240 (4.0%) of all deaths in neonatal period, 8838 (10.5%) among all post-neonatal infant deaths, and 15 554 (31.7%) among children with 1-4 years of age. Among four tested models, the most predictive was used to...

  2. Cost of accidental carbon monoxide poisoning: A preventable expense.

    Hampson, Neil B

    2016-06-01

    Carbon monoxide (CO) poisoning is common in the United States, accounting for hundreds of deaths and thousands of emergency department visits annually. It is believed that most accidental CO poisoning is preventable through public education, warning labels on consumer products, and uniform use of residential CO alarms. However, cost effectiveness of these prevention strategies has not been demonstrated in the United States to date. It was the objective of this study to estimate societal cost of accidental CO poisoning and evaluate the cost-effectiveness of universal installation of residential CO alarms. Published studies and data from the English language literature were used in to estimate direct hospital costs and lost earnings resulting from accidental CO poisoning. The study was performed in the US in 2015. Approximately 6600 individuals are estimated to sustain long-term cognitive sequela annually, with total loss in earnings of approximately $925 million, 334 individuals die from accidental, non-fire related CO poisoning with an average loss of 26 years of productivity accounting for $355 million, and 2800 are hospitalized with acute medical care costs of $33 million. Available data indicate that accidental CO poisoning in the US conservatively costs society over $1.3 billion, resulting from direct hospital costs and lost earnings. Further, it demonstrates a positive cost-benefit ratio for the uniform use of residential CO alarms. PMID:26844181

  3. Laboratory diagnosis of leptospirosis

    Ahmad S; Shah S; H Ahmad F

    2005-01-01

    Leptospirosis is a worldwide zoonosis caused by pathogenic Leptospira species, for which humans are accidental hosts. It is endemic in the tropical urban areas including our country, where seasonal epidemics are becoming increasingly common. Laboratory tests are necessary to confirm the diagnosis of clinically suspected leptospirosis due to its varied symptomatology. Moreover, leptospirosis must always be considered during the differential diagnosis of other tropical febrile illnesses .Labora...

  4. The influence of season of the year on the predicted agricultural consequences of accidental releases of radionuclides to atmosphere

    In Europe, because of the seasonal nature of agricultural practices, the consequences for agriculture of an accidental release of radioactive materials to atmosphere are likely to vary depending upon the time of year when the release occurs. The quantification of this variation is complicated by the need to take into account the introduction of countermeasures to restrict the radiation exposure from ingestion of contaminated foods, and by the presence in accidental releases of radionuclides which persist over several seasons. In this study, the effect on agricultural consequences of accidental releases occurring at different times of the year is examined. The consequences are expressed in terms of the amount of produce affected by restrictions on food supplies and the collective radiation dose from ingestion of food. The investigation has been carried out for three hypothetical releases representing a range of releases postulated for pressurised water reactors (PWRs). The effect of season of the year was determined for accidental releases occurring both in a single, defined set of meteorological conditions and for a range of possible meteorological conditions. For the main part of the study, consideration was limited to agricultural production in the UK only, but the effect of extending the analysis beyond the UK boundary was also considered. The results of the study show that considerable variation can occur in agricultural consequences following an accidental release at different times of the year. For the larger releases considered, this variation is reduced due to the effect of the introduction of countermeasures, particularly when consideration is limited to the UK only. Seasonal variation tends to be greater for the results of a deterministic analysis, which uses a single set of constant meteorological conditions, than for the results of a full probabilistic assessment. From the results presented here it is also seen that for many applications of

  5. Tissue distribution of organochlorine pesticides in largemouth bass (Micropterus salmoides) from laboratory exposure and a contaminated lake.

    Dang, Viet D; Kroll, Kevin J; Supowit, Samuel D; Halden, Rolf U; Denslow, Nancy D

    2016-09-01

    Tissue concentrations of persistent organochlorine pesticides in laboratory-exposed largemouth bass (Micropterus salmoides) and in bass collected from Lake Apopka, FL were determined by both total mass and lipid normalized mass to better understand the bioaccumulation pathways of contaminants. In the laboratory study, male bass were orally administered a single dose of a mixture of two pesticides (p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) and dieldrin) and then fed uncontaminated food for 28 days. Gastrointestinal tract, liver, brain, gonad, kidney, spleen, and muscle were collected for chemical analysis. Different profiles were observed by total contaminant mass in tissues compared to lipid normalized mass. On a lipid normalized basis, p,p'-DDE was highest in the gastrointestinal tract followed by the liver, gonad, spleen, muscle, kidney and then brain. Dieldrin, on the other hand, was highest in the gastrointestinal tract and spleen and then followed by the gonad, muscle, liver, kidney, and brain. Distribution of the chemicals among the organs differed by their log KOW values and generally followed the blood flow path after the gastrointestinal tract. The low contaminant levels found in kidney and brain suggest insufficient time for equilibration into these tissues, especially into the brain where the blood-brain barrier may be slow to traverse. In Lake Apopka fish, dichlorodiphenyltrichloroethanes (DDXs, sum of p,p'-DDE, p,p'-DDD, and p,p'-DDT), Drins (sum of aldrin, dieldrin, and endrin), and hexachlorocyclohexanes (HCHs) were found. For DDXs, the lipid normalized concentrations in each tissue were about the same, as predicted from theory. For Drins and HCHs, the lipid normalized concentrations were similar for kidney, spleen, brain, gonad and muscle, but much lower in the gastrointestinal tract and liver, probably because of metabolism occurring in those tissues. PMID:27394080

  6. Accidental carbon monoxide poisoning in our homes

    Sharma Shruti

    2009-01-01

    Full Text Available Carbon monoxide (CO is a colorless, odorless, tasteless, nonirritating, but significantly toxic gas. It is a product of combustion of organic matter in presence of insufficient oxygen supply. Symptoms of mild poisoning include headaches, vertigo and flu like effects, whereas larger exposures can lead to significant toxicity of the central nervous system (CNS, heart, and even death. We are reporting two cases that presented to us in the winter months of December to January with history, sign, symptoms, and radiological evidence of suspected CO poisoning.

  7. Correcting for accidental correlations in saturated avalanche photodiodes

    Grieve, James A; Tang, Zhongkan; Ling, Alexander

    2015-01-01

    In this paper we present a high-level numerical model for estimating rates of accidental correlations between a pair of passively quenched Geiger mode avalanche photodiodes operating in the saturated regime. By considering the recovery time of both the diodes and the detection circuit we introduce the concept of an "effective duty cycle" and show that it may be estimated by numeric simulation. The impact of effective duty cycle on the observed accidental rate is examined and we demonstrate that the updated model leads to an improved correction factor in actual experiments. This will improve the signal-to-noise ratio in applications depending on correlation measurements.

  8. Accidental ingestion of a fractured Twin-block appliance.

    Rohida, Neeraj S; Bhad, Wasundhara A

    2011-01-01

    Orthodontic appliances that become dislodged can cause problems in the airway or the gastrointestinal tract. Accidental ingestion of an appliance during a chair-side procedure or because of inadequate retention of the appliance can create a medical emergency with potentially serious complications, including death from aspiration of the foreign body. This article reports the accidental ingestion of a fractured Twin-block appliance. The ease with which removable appliances can become dislodged if retention is inadequate is discussed, and some serious complications that can arise are described. Precautions the orthodontist can take to prevent such accidents are presented. PMID:21195285

  9. Organizational influence on the occurrence of work accidents involving exposure to biological material La influencia de la organización en la ocurrencia de accidentes de trabajo con exposición a material biológico Influência organizacional na ocorrência de acidentes de trabalho com exposição a material biológico

    Maria Helena Palucci Marziale; Fernanda Ludmilla Rossi Rocha; Maria Lúcia do Carmo Cruz Robazzi; Camila Maria Cenzi; Heloisa Ehmke Cardoso dos Santos; Marli Elisa Mendes Trovó

    2013-01-01

    OBJECTIVES: to analyze work accidents involving exposure to biological materials which took place among personnel working in nursing and to evaluate the influence of the organizational culture on the occurrence of these accidents. METHOD: a retrospective, analytical study, carried out in two stages in a hospital that was part of the Network for the Prevention of Work Accidents. The first stage involved the analysis of the characteristics of the work accidents involving exposure to biological ...

  10. Health Physics Laboratory - Overview

    (RACE - Rapid Assessment of aCcidental Exposures) based on ultra-sensitive MCP-N detectors developed at the laboratory. In 1998 a technical project concerned with refurbishing the calibration laboratory for radiation protection was also completed. A new irradiation assembly with a high-intensity Cs-137 source, an automatic dosimetric bench and a high-class ionisation chamber with electrometer were installed and put in operation. They allow one to precisely calibrate personal dosimeters and radiation protection monitors. The investigations of the concentration of radon in houses and in soil using CR-39 plastic detectors, were continued together with the group of Prof. Jerzy Loskiewicz. The Laboratory successfully took part in the intercomparison of passive radon detectors (3% deviation, 9th place out of 70 participants) organised in NRPB, Great Britain. Several of the research projects involved measurements and detector irradiation in collaborating laboratories abroad and visits by foreign experts. The TLD detectors were irradiated in the medical proton beam at the Hahn-Meitner Institute in Berlin in ISL laboratory. The response of MCP-N detectors after low-energy X-rays from a synchrotron light source was investigated with the chips exposed at Stanford (USA). LiF:Mg, Ti detectors with different concentration of Ti and Mg were prepared for experiments in the medical proton beam at Louvain, Belgium. Dr Barbara Marczewska continued her study of TL materials based on CaF2:Tm. We plan to use CaF2:Tm detectors in measurements of doses in proton beams

  11. Genetic Damage Induced by Accidental Environmental Pollutants

    Beatriz Pérez-Cadahía

    2006-01-01

    Full Text Available Petroleum is one of the main energy sources worldwide. Its transport is performed by big tankers following some established marine routes. In the last 50 years a total amount of 37 oil tankers have given rise to great spills in different parts of the world, Prestige being the last one. After the accident, a big human mobilisation took place in order to clean beaches, rocks and fauna, trying to reduce the environmental consequences of this serious catastrophe. These people were exposed to the complex mixture of compounds contained in the oil. This study aimed at determine the level of environmental exposure to volatile organic compounds (VOC, and the possible damage induced on the population involved in the different cleaning tasks by applying the genotoxicity tests sister chromatid exchanges (SCE, micronucleus (MN test, and comet assay. Four groups of individuals were included: volunteers (V, hired manual workers (MW, hired high-pressure cleaner workers (HPW and controls. The higher VOC levels were associated with V environment, followed by MW and lastly by HPW, probably due to the use of high-pressure cleaners. Oil exposure during the cleaning tasks has caused an increase in the genotoxic damage in individuals, the comet assay being the most sensitive biomarker to detect it. Sex, age and tobacco consumption have shown to influence the level of genetic damage, while the effect of using protective devices was less noticeable than expected, perhaps because the kind used was not the most adequate.

  12. Aerosolized avian influenza virus by laboratory manipulations

    Li Zhiping

    2012-08-01

    Full Text Available Abstract Background Avian H5N1 influenza viruses present a challenge in the laboratory environment, as they are difficult to collect from the air due to their small size and relatively low concentration. In an effort to generate effective methods of H5N1 air removal and ensure the safety of laboratory personnel, this study was designed to investigate the characteristics of aerosolized H5N1 produced by laboratory manipulations during research studies. Results Normal laboratory procedures used to process the influenza virus were carried out independently and the amount of virus polluting the on-site atmosphere was measured. In particular, zootomy, grinding, centrifugation, pipetting, magnetic stirring, egg inoculation, and experimental zoogenetic infection were performed. In addition, common accidents associated with each process were simulated, including breaking glass containers, syringe injection of influenza virus solution, and rupturing of centrifuge tubes. A micro-cluster sampling ambient air pollution collection device was used to collect air samples. The collected viruses were tested for activity by measuring their ability to induce hemagglutination with chicken red blood cells and to propagate in chicken embryos after direct inoculation, the latter being detected by reverse-transcription PCR and HA test. The results showed that the air samples from the normal centrifugal group and the negative-control group were negative, while all other groups were positive for H5N1. Conclusions Our findings suggest that there are numerous sources of aerosols in laboratory operations involving H5N1. Thus, laboratory personnel should be aware of the exposure risk that accompanies routine procedures involved in H5N1 processing and take proactive measures to prevent accidental infection and decrease the risk of virus aerosol leakage beyond the laboratory.

  13. Prevalence of renal and hepatobiliary disease, laboratory abnormalities, and potentially toxic medication exposures among persons with COPD

    Mapel DW

    2013-03-01

    Full Text Available Douglas W Mapel,1 Jenõ P Marton21Lovelace Clinic Foundation, Albuquerque, New Mexico, NM, USA; 2Health Economics and Outcomes Research, Pfizer Inc, New York, NY, USABackground: The purpose of this study was to describe the prevalence of renal and hepatic disease, related laboratory abnormalities, and potentially hepatotoxic and nephrotoxic medication use in a population-based cohort of persons with chronic obstructive pulmonary disease (COPD.Methods: This was a retrospective case-control cohort analysis of COPD patients enrolled in one regional health system for at least 12 months during a 36-month study period (n = 2284. Each COPD patient was matched by age and gender to up to three persons not diagnosed with COPD (n = 5959.Results: The mean age for cases and controls was 70.3 years, and 52.5% were women. The COPD cohort had significantly higher prevalences (cases/100 of acute, chronic, and unspecified renal failure as compared with controls (1.40 versus 0.59, 2.89 versus 0.79, and 1.09 versus 0.44, respectively. Among the cases, 31.3% had at least one renal or urinary tract diagnosis during the study period, as compared with 21.1% of controls. COPD cases also had more gallbladder disease (2.76 versus 1.63 and pancreatic disease (1.40 versus 0.60, but not hepatic disease. COPD patients were more likely to have at least one serum creatinine level (5.1 versus 2.1 or liver aspartate aminotransferase level (4.5 versus 2.7 that was more than twice the upper limit of normal. COPD patients had prescription fills for an average of 17.6 potentially nephrotoxic and 27.4 hepatotoxic drugs during the study period, as compared with 13.6 and 19.9 for the controls (P value for all comparisons < 0.01.Conclusion: COPD patients have a substantially increased prevalence of renal, gallbladder, and pancreatic diseases, as well as abnormal renal and hepatic laboratory values, but not diagnosed liver disease. COPD patients are also more likely to be prescribed

  14. Occupational exposure to mineral oil metalworking fluid (MWFs) mist: Development of new methodologies for mist sampling and analysis. Results from an inter-laboratory comparison

    Metalworking Fluids (MWFs) are largely used in the sector of undercutting, a large professional activity in Switzerland, in particular in the fine mechanic and watch making industry. France proposes a Permissible Exposure Limit (PEL) of 1 mg.m-3 of aerosol. The American Conference of Governmental Industrial Hygienists (ACGIH) sets its value at 5 mg.m-3 but a proposal to lower the standard ('intended changes') to 0.2 mg.m-3 of aerosol is pending since 2001. However, it has not become a recognized threshold limit value for exposure. Since 2003, the new Swiss PEL (MAK) recommendations would be 0.2 mg.m-3 of aerosol (oil with boiling point > 350 deg. C without additives) and/or 20 mg.m-3 of oil aerosol + vapour for medium or light oil. To evaluate evaporative losses of sampled oil, the German 'Berufsgenossenschaftliches Institut fuer Arbeitssicherheit' (BGIA) recommends the use of a XAD-2 cartridge behind the filter. The method seems to work perfectly for MWFs in a clean occupational atmosphere free from interference of light vapour cleaning solvent such as White Spirit. But, in real situation, machine shop atmosphere contaminated with traces of White Spirit, the BGIA method failed to estimate the MWFs levels (over-estimation). In this paper, we propose a new approach meant to measure both oil vapours and aerosols. Five inter-laboratory comparisons are discussed, based on the production of oil mist in an experimental chamber under controlled conditions.

  15. Occupational exposure to mineral oil metalworking fluid (MWFs) mist: Development of new methodologies for mist sampling and analysis. Results from an inter-laboratory comparison

    Khanh Huynh, C.; Herrera, H.; Parrat, J.; Wolf, R.; Perret, V.

    2009-02-01

    Metalworking Fluids (MWFs) are largely used in the sector of undercutting, a large professional activity in Switzerland, in particular in the fine mechanic and watch making industry. France proposes a Permissible Exposure Limit (PEL) of 1 mg.m-3 of aerosol. The American Conference of Governmental Industrial Hygienists (ACGIH) sets its value at 5 mg.m-3 but a proposal to lower the standard ("intended changes") to 0.2 mg.m-3 of aerosol is pending since 2001. However, it has not become a recognized threshold limit value for exposure. Since 2003, the new Swiss PEL (MAK) recommendations would be 0.2 mg.m-3 of aerosol (oil with boiling point > 350°C without additives) and/or 20 mg.m-3 of oil aerosol + vapour for medium or light oil. To evaluate evaporative losses of sampled oil, the German "Berufsgenossenschaftliches Institut für Arbeitssicherheit" (BGIA) recommends the use of a XAD-2 cartridge behind the filter. The method seems to work perfectly for MWFs in a clean occupational atmosphere free from interference of light vapour cleaning solvent such as White Spirit. But, in real situation, machine shop atmosphere contaminated with traces of White Spirit, the BGIA method failed to estimate the MWFs levels (over-estimation). In this paper, we propose a new approach meant to measure both oil vapours and aerosols. Five inter-laboratory comparisons are discussed, based on the production of oil mist in an experimental chamber under controlled conditions.

  16. Medical handling of accidentally exposed individuals

    In 1978 the International Atomic Energy Agency issued a publication in the IAEA Safety Series entitled Manual on Early Medical Treatment of Possible Radiation Injury (Safety Series No. 47). The contents were directed to first aid and early medical treatment of workers who might be concerned in an accident involving exposure to radiation, whether external or internal. The present manual is the first of a set of three safety series publications dealing with assessment and treatment of overexposures which will constitute an articulated system of documents covering all aspects of diagnosis, prognosis and treatment of overexposures. This document establishes a set of general criteria and recommendations to aid specialists involved in the medical handling of overexposed persons. It deals with the medical management of individual patients or small groups of patients under close medical supervision. 14 refs, 7 figs, 7 tabs

  17. Evaluation of tissue and cellular biomarkers to assess 2,4,6-trinitrotoluene (TNT) exposure in earthworms: effects-based assessment in laboratory studies using Eisenia andrei.

    Robidoux, Pierre Yves; Svendsen, Claus; Sarrazin, Manon; Hawari, Jalal; Thiboutot, Sonia; Ampleman, Guy; Weeks, Jason M; Sunahara, Geoffrey I

    2002-01-01

    The lysosomal neutral red retention time (NRRT) assay, a biomarker for lysosomal membrane stability, and the total immune activity (TIA) assay, a measure of non-specific immune system activity, were used in laboratory studies to assess the toxic effects of 2,4,6-trinitrotoluene (TNT) on earthworms (Eisenia andrei) in vivo. The results were compared with the concentration of TNT and its metabolites in earthworm tissue, as well as standard sublethal toxicity endpoints including growth (i.e. weight change) and reproduction effects from previously published studies. Filter paper experiments indicated a significant decrease in NRRT at >or=1.8 micro g TNT cm(-2), whereas sublethal (weight loss) and lethal effects to earthworms were detected at >or=3.5 and 7.1 micro g TNT cm(-2), respectively. Experiments in artificial soil showed that NRRT effects could be detected at lower TNT concentrations (>or=55 mg TNT kg(-1) soil dry weight) compared with other sublethal endpoints (effects on growth and reproduction). The TIA biomarker did not significantly respond to TNT. Copper (as CuSO4, filter paper contact tests) and 2-chloroacetamide (soil tests), which were used as reference toxicants, also decreased the NRRT. The use of the NRRT assay linked with tissue concentrations of TNT metabolites in earthworms was identified as a potentially appropriate biomarker approach for TNT exposure assessment under laboratory conditions and a novel tool for effects-based risk assessment. PMID:12171758

  18. Accidental Ingestion of Endodontic File: A Case Report

    Chandak, Manoj G.; Pradnya P. Nikhade; Saraf, Hrushikesh P.

    2012-01-01

    Ingestion of the endodontic instrument during root canal treatment is rare but can result in serious complications. The present paper reports a case in which endodontic file was accidentally swallowed by the patient undergoing root canal therapy, which entered digestive tract and passed uneventfully.

  19. Are diabetic foot lesions precipitated by accidental trauma?

    Doshi, H K; Moissinac, K; Harwant, S

    2001-12-01

    Diabetic foot lesions may arise from frictional trauma due to tight or inappropriate footwear, repetitive stresses on parts of the foot, overlying bony prominence generated by walking and accidental trauma to the neuropathic foot. Many diabetics have been found to be unaware of their foot lesion, or know what the precipitating cause was. Based on the assumption that accidental trauma would affect the foot in a random fashion and result in lesions distributed evenly throughout the foot, a study was performed to determine whether foot lesions were distributed evenly or concentrated to certain areas of predilection. It was found that foot lesions were not evenly distributed but concentrated to certain areas of predilection. Even though relatively high proportion of the study population walked about in open slippers and barefeet, the study showed that accidental trauma was not a predominant precipitant of diabetic foot lesions. Diabetic foot lesions tend to occur as a result of cumulative, repetitive trauma to areas of prediliection rather than accidental trauma. PMID:14569763

  20. Study of stowage of radioactive materials packagings in accidental conditions

    The study of transport conditions shows that few data are available on accidental conditions. Two types of accidents are selected and defined by calculations and tests. Sizing of stowage is determined for a frontal shock (35 g deceleration), maintaining the packaging on the vehicle, and side shock rupture of the stowage system for a determined stress. Mathematical formulations are developed

  1. 49 CFR 192.751 - Prevention of accidental ignition.

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Prevention of accidental ignition. 192.751 Section 192.751 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Maintenance § 192.751 Prevention...

  2. Brugada syndrome unmasked by accidental inhalation of gasoline vapors

    Kranjcec, Darko; Bergovec, Mijo; Rougier, Jean-Sébastien;

    2007-01-01

    Loss-of-function mutations in the gene SCN5A can cause Brugada syndrome (BrS), which is an inherited form of idiopathic ventricular fibrillation. We report the case of a 46-year-old patient, with no previous medical history, who had ventricular fibrillation after accidental inhalation of gasoline...

  3. Responsabilidad del empleador por accidentes de trabajo y enfermedades profesionales

    Cristina Mangarelli

    2014-01-01

    Full Text Available Introducción. 1. Responsabilidad del “empleador” por accidentes de trabajo y enfermedades profesionales. Noción. 2. La indemnización “tarifada”. Fundamento de su procedencia 3. Responsabilidad del empleador por accidentes de trabajo o enfermedades profesionales en la ley uruguaya (ley Nº 16.074. 4. La “ampliación” de la responsabilidad del empleador por el derecho común en el derecho uruguayo (artículo 7 ley Nº 16.074. 5. Requisitos para la ampliación de la responsabilidad patronal: culpa grave en el incumplimientode normas de seguridad y prevención. 6. La culpa grave. Concepto. 7. El modelo del hombre a tener en cuenta en la “culpa grave” no es el del buen padre de familia. 8. El grado de la culpa no puede ser medido por el resultado del accidente. 9. Se aplican las eximentes de la responsabilidad civil. 10. Distintos ámbitos de la responsabilidad patronal por accidentes de trabajo o enfermedades profesionales: A ante la víctima o los derecho-habientes; B ante el Banco de Seguros del Estado; C ante el Ministerio de Trabajo ySeguridad Social. 11. Recupero del BSE en caso de culpa grave en el incumplimiento de normas de seguridad y prevención. Requisitos 12. Responsabilidad del empleador en caso de accidente de trabajo o enfermedad profesional sufrido por un adolescente. Conclusiones.

  4. Accidental nuclear excursion recuplex operation 234-5 facility: Final medical report

    Fuqua, P. A.

    1962-04-07

    The April 7, 1962 criticality accident involving human exposures was the first to have occurred in any production facility at Hanford. The accidental nuclear excursion did not result in any mechanical damage or spread of contamination. Three employees received over-exposure to gamma and neutron radiation. None were fatally exposed and in each case the over-exposure was recognized promptly. Following an initial period of medical observation and testing, the men were released to work. They continued to be followed clinically. Clinical studies performed were hematological procedures including leukocyte chromosome aberrations, morphologically aberrant blood cells, bone marrow evaluations, blood chemistry determinations, amino acid excretion studies, seminal fluid, urinary gonadotropins and estrogen excretion studies, testicular biopsies and crystalline lens examinations. These studies, along with a brief description of the accident and of the dosimetry, are summarized in this report by those participating in the studies. In view of the dose ranges received in these cases, both the negative and positive findings are considered to be of unusual interest due to the lack of knowledge of effects following human exposures at these levels.

  5. 40 CFR 63.95 - Additional approval criteria for accidental release prevention programs.

    2010-07-01

    ... accidental release prevention programs. 63.95 Section 63.95 Protection of Environment ENVIRONMENTAL... Additional approval criteria for accidental release prevention programs. (a) A State submission for approval... (“federally-listed chemicals”) that an approvable State Accidental Release Prevention program is...

  6. Psychosocial factors and safety behaviour as predictors of accidental work injuries in farming

    Glasscock, David John; Rasmussen, Kurt; Carstensen, Ole;

    2006-01-01

    Farming is one of the most hazardous occupations in terms of the incidence and seriousness of accidental injuries. Research with other occupational groups has drawn attention to the role of psychosocial factors and stress. Such research needs to be extended to agriculture. Since stress may be a...... problem faced by farmers, there is a particular need to investigate the associations between farm accidents and work stressors and stress reactions. Using multivariate logistic regression analyses, this study aimed to uncover the best psychosocial predictors of injury, while controlling for exposure......-related confounders. From a randomly selected sample of 794 farms, 10% of all farms in Ringkoebing County, Denmark, 393 farmers completed completed weekly accident registration over 12 months. The study sample consisted of 310 farmers who also completed questionnaires on psychosocial factors. Results indicated that...

  7. Investigation of thermoluminescence properties of mobile phone screen displays as dosimeters for accidental dosimetry

    Mrozik, Anna; Marczewska, B.; Bilski, P.; Kłosowski, M.

    2014-11-01

    The rapid assessment of the radiation dose after unexpected exposure is a task of accidental dosimetry. In case of a radiological accident glasses originating from mobile phone screens, placed usually near the human body, could be used as emergency thermoluminescent (TL) personal dosimeters. The time between irradiation and TL readout is crucial and therefore preparation of the mobile phone screens and their readout conditions should be optimized. The influence of the samples etching, bleaching and selection of the optical filters based on measurement of the emission spectrum of irradiated glass samples during heating for different types of mobile phones were the subjects of our investigation. Obtained results showed that glasses extracted from different brands of mobile phones have different dosimetric properties but all of them give a luminescent signal which can be used to calculate the dose.

  8. Dynamic evaluation of environmental impact due to tritium accidental release from the fusion reactor

    As one of the key safety issues of fusion reactors, tritium environmental impact of fusion accidents has attracted great attention. In this work, the dynamic tritium concentrations in the air and human body were evaluated on the time scale based on accidental release scenarios under the extreme environmental conditions. The radiation dose through various exposure pathways was assessed to find out the potential relationships among them. Based on this work, the limits of HT and HTO release amount for arbitrary accidents were proposed for the fusion reactor according to dose limit of ITER. The dynamic results aim to give practical guidance for establishment of fusion emergency standard and design of fusion tritium system. - Highlights: • Dynamic tritium concentration in the air and human body evaluated on the time scale. • Different intake forms and relevant radiation dose assessed to find out the potential relationships. • HT and HTO release amount limits for arbitrary accidents proposed for the fusion reactor according to dose limit

  9. Dynamic evaluation of environmental impact due to tritium accidental release from the fusion reactor.

    Nie, Baojie; Ni, Muyi; Jiang, Jieqiong; Wu, Yican

    2015-10-01

    As one of the key safety issues of fusion reactors, tritium environmental impact of fusion accidents has attracted great attention. In this work, the dynamic tritium concentrations in the air and human body were evaluated on the time scale based on accidental release scenarios under the extreme environmental conditions. The radiation dose through various exposure pathways was assessed to find out the potential relationships among them. Based on this work, the limits of HT and HTO release amount for arbitrary accidents were proposed for the fusion reactor according to dose limit of ITER. The dynamic results aim to give practical guidance for establishment of fusion emergency standard and design of fusion tritium system. PMID:26164282

  10. [Protection of the Croatian population from accidental radioactive contamination of the food chain].

    Lokobauer, N; Franić, Z; Bauman, A

    1993-03-01

    The paper indicates the importance of investigating radionuclide translocation in the human food chain, and the contribution of selected food components in total exposure of the population after accidental radioactive contamination. Data on radioactive contamination and risk assessment of the Croatian population after the Chernobyl nuclear accident are given and possibilities of decontamination of food chain components are discussed. Literature data on radionuclide removal from the human food chain are compared to the results of own investigations. Emphasis is placed on biologically most important radionuclides, 131I, 90Sr, 137Cs, and the most effective means of protection are sought. The preventive measures following a nuclear accident should be based on the cost-benefit principle i.e. the damage from applying radiation protection measures should not exceed the benefit from possible dose reduction. PMID:8347101

  11. Acute behavioural dysfunctions following exposure to γ-rays

    Exposure to ionizing radiations (IR) has been reported to have many ill effects. These are manifested immediately after exposure and may persist or develop long after the incident. The severity and manifestation is dependent on the absorbed dose and type of the IR. These have been reported extensively in human subjects; especially among the victims of the accidental exposure and radiotherapy patients. Additionally, there have been a plethora of studies in animal models which support these findings, and are being used to test radio-mitigative or radio-protective strategies. The vulnerability of neuronal tissue to IR is well known, however the acute dose-dependent behavioural consequences have yet to be understood. Thus, our laboratory has been trying to decipher the dose-dependent behavioural dysfunctions which have occurred 24-72 hours post IR exposure and possible radio-protective strategies. We are utilizing mouse models of studying the behavioural processes, in a test battery conceptualized to study the affective and cognitive skills as well as motor skills of the animals. Additionally, we have observed cellular damage to different areas of the brain and subsequent correlations to behavioural dysfunctions. This has being carried out by using single cell gel electrophoresis (SCGE) and Diffusion Tensor Imaging (DTI). The findings show that after exposure to sub-lethal γ-rays, there are significant changes that occur in all the behavioural parameters. The most sensitive area has been found to be the Hippocampus as visualized by DTI and the SCGE. Consequently, short term and long term memory functions have been shown to be disrupted within 24-72 hours of exposure. Acute dysfunctions of affective functions have also been demonstrated to materialise within 24 hours post exposure. Unexpectedly, the behavioural dysfunctions were seen to be dose independent. Thus, this study provides a foundation to help decipher the acute behavioural manifestations of IR exposure

  12. Exposure to formaldehyde: a challenge of occupational health significance

    The use of formaldehyde as the fixative for general microscopic demonstration of tissues in medical laboratory establishments is as significant as the diagnosis of the underlying ailment. Instantaneous human exposure to formaldehyde elicits symptoms that may include watery eyes, headache, inflamed throat and dyspnea. The gaseous chemical is toxic, allergenic and carcinogenic. A study to determine the incidence of human exposure to formaldehyde was carried out at the University Teaching Hospital in Lusaka, Zambia from January to December, 2007. Anonymous questionnaires on various aspects of human exposure to formaldehyde were given to laboratory technical personnel. Exposure to formaldehyde was determined using general consideration model comprising points awarded to participants according to their responses. Five points represented the maximum level of exposure, while one point denoted the minimum encounter. There were 8 incidents of formaldehyde pollution, with five being emissions from 210-litre formalin receptacles whose stoppers were inadvertently left loose overnight, while three involved accidental breakage of Winchester bottles of formalin. A total of 115 people were exposed during the year. Fifteen (13.0 percent) participants scored one point each, while 20 (17.4 percent) participants obtained 2 points each. Thirty-five (30.4 percent) participants got 3 points each, while 30 (26.0 percent) participants received 4 points each. Twenty-five (21.7 percent) participants attained 5 points each. Human exposure to formaldehyde is an issue of occupational health concern. Participants with a score of 3 points or more need regular medical check ups in order to safeguard their health. Programs on effective management of hazardous chemicals are worth setting up.(author)

  13. Formation of Glycidyl Fatty Acid Esters Both in Real Edible Oils during Laboratory-Scale Refining and in Chemical Model during High Temperature Exposure.

    Cheng, Weiwei; Liu, Guoqin; Liu, Xinqi

    2016-07-27

    In the present study, the formation mechanisms of glycidyl fatty acid esters (GEs) were investigated both in real edible oils (soybean oil, camellia oil, and palm oil) during laboratory-scale preparation and refining and in chemical model (1,2-dipalmitin (DPG) and 1-monopalmitin (MPG)) during high temperature exposure (160-260 °C under nitrogen). The formation process of GEs in the chemical model was monitored using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy. The results showed that the roasting and pressing process could produce certain amounts of GEs that were much lower than that produced in the deodorization process. GE contents in edible oils increased continuously and significantly with increasing deodorization time below 200 °C. However, when the temperature exceeded 200 °C, GE contents sharply increased in 1-2 h followed by a gradual decrease, which could verify a simultaneous formation and degradation of GEs at high temperature. In addition, it was also found that the presence of acylglycerol (DAGs and MAGs) could significantly increase the formation yield of GEs both in real edible oils and in chemical model. Compared with DAGs, moreover, MAGs displayed a higher formation capacity but substantially lower contribution to GE formation due to their low contents in edible oils. In situ ATR-FTIR spectroscopic evidence showed that cyclic acyloxonium ion intermediate was formed during GE formation derived from DPG and MPG in chemical model heated at 200 °C. PMID:27319409

  14. Accidental intraoral injection of formalin during extraction: case report.

    Swami, Pushp Chander; Raval, Rushik; Kaur, Mandeep; Kaur, Jasleen

    2016-04-01

    Transparent, clear solutions such as hydrogen peroxide, alcohol, sodium hypochlorite, formaldehyde, and local anaesthetics are widely used in dentistry, so the tissues are liable to accidental injury. Formalin, a 37%-40% solution of formaldehyde, is extensively used in 10% solution as a tissue preservative, but it has toxic effects on systems such as the gastrointestinal tract, respiratory tract, skin, and mucosa. However, we know of few reports of cases of inadvertent injection of alcohol and formalin directly into the human body. In this case report we describe the early and delayed clinical effects of accidental intraoral injection of formalin, the subsequent symptoms and management, and some prudent points that should be learnt to avoid such incidents in the future. PMID:26794082

  15. Leading global projects for professional and accidental project leaders

    Moran, Robert T

    2008-01-01

    This book is a must-read for anyone responsible for projects and initiatives that span functional and geographical divides. Authors Moran and Youngdahl bring extensive experience and learning from industry practice to present a clear and straightforward treatment of the leadership skills and knowledge required to lead projects that are global in nature. They have written the first book of its kind to address the three essential skills of global project leaders - strategic project management, project leadership, and cross-cultural leadership. The authors argue that global project leadership is an essential skill in our project-based world and that we are all either intentional or accidental project leaders. Intentional project leaders pursue formal project management education and even certification whereas accidental project leaders find themselves leading global projects and initiatives as a result of a special assignment or promotion. Moran and Youndahl have found that the vast majority of global projects ...

  16. Accidental degeneracy of double Dirac cones in a phononic crystal

    Chen, Ze-Guo

    2014-04-09

    Artificial honeycomb lattices with Dirac cone dispersion provide a macroscopic platform to study the massless Dirac quasiparticles and their novel geometric phases. In this paper, a quadruple-degenerate state is achieved at the center of the Brillouin zone in a two-dimensional honeycomb lattice phononic crystal, which is a result of accidental degeneracy of two double-degenerate states. In the vicinity of the quadruple-degenerate state, the dispersion relation is linear. Such quadruple degeneracy is analyzed by rigorous representation theory of groups. Using method, a reduced Hamiltonian is obtained to describe the linear Dirac dispersion relations of this quadruple-degenerate state, which is well consistent with the simulation results. Near such accidental degeneracy, we observe some unique properties in wave propagating, such as defect-insensitive propagating character and the Talbot effect.

  17. Timing, ``Accidentals'' and Other Artifacts in EPR Experiments

    Thompson, Caroline H.

    1997-01-01

    Subtraction of ``accidentals'' in Einstein-Podolsky-Rosen experiments frequently changes results compatible with local realism into ones that appear to demonstrate non-locality. The validity of the procedure depends on the unproven assumption of the independence of emission events. Other possible sources of bias include enhancement, imperfect synchronisation, over-reliance on rotational invariance, and the well-known detection loophole. Investigation of existing results may be more fruitful t...

  18. Paediatric femur fractures at the emergency department: accidental or not?

    Hoytema van Konijnenburg, Eva M M; Vrolijk-Bosschaart, Thekla F; Bakx, Roel; Van Rijn, Rick R

    2016-01-01

    Only a small proportion of all paediatric fractures is caused by child abuse or neglect, especially in highly prevalent long bone fractures. It can be difficult to differentiate abusive fractures from non-abusive fractures. This article focuses on femoral fractures in young children. Based on three cases, this article presents a forensic evidence-based approach to differentiate between accidental and non-accidental causes of femoral fractures. We describe three cases of young children who were presented to the emergency department because of a suspected femur fracture. Although in all cases, the fracture had a similar location and appearance, the clinical history and developmental stage of the child led to three different conclusions. In the first two cases, an accidental mechanism was a plausible conclusion, although in the second case, neglect of parental supervision was the cause for concern. In the third case, a non-accidental injury was diagnosed and appropriate legal prosecution followed. Any doctor treating children should always be aware of the possibility of child abuse and neglect in children with injuries, especially in young and non-mobile children presenting with an unknown trauma mechanism. If a suspicion of child abuse or neglect arises, a thorough diagnostic work-up should be performed, including a full skeletal survey according to the guidelines of the Royal College of Radiologists and the Royal College of Paediatrics and Child Health. In order to make a good assessment, the radiologist reviewing the skeletal survey needs access to all relevant clinical and social information. PMID:26642309

  19. The Classification of Accidental Situations’ Scenarios on Hydropower Plants

    Skvortsova Olga; Dashkina Anastasiia; Petrovskaia Ekaterina; Terleev Vitaly; Nikonorov Aleksandr; Badenko Vladimir; Volkova Yulia; Pavlov Sergey

    2016-01-01

    The collapse of hydropower plant could lead to significant financial, social and environmental damages. Accordingly the issue of safety and reliability is one of major problems of designing, maintenance and operation. The proposed solution consists in evaluation of implementation frequency of emergencies scenario, which can be defined by suggested classification of accidental situations’ scenarios based on systems analysis to implement incidents on hydropower plants. Emergency scenarios on hy...

  20. Accidental Symmetries and N=1 Duality in Supersymmetric Gauge Theory

    Leigh, Robert G; Leigh, Robert G.; Strassler, Matthew J.

    1996-01-01

    We note that the accidental symmetries which are present in some examples of duality imply the existence of continuously infinite sets of theories with the same infrared behavior. These sets interpolate between theories of different flavors and colors; the change in color and flavor is compensated by interactions (often non-perturbative) induced by operators in the superpotential. As an example we study the behavior of SU(2) gauge theories with 2\

  1. A case of accidental ingestion of ant bait containing fipronil.

    Fung, Hin Tat; Chan, Kar Ki; Ching, Wei Ming; Kam, Chak Wah

    2003-01-01

    A 77-year-old woman accidentally ingested a commercial ant bait containing fipronil without development of obvious toxicity, supporting the safety of this new insecticide as demonstrated in animal studies. However, concentrated agricultural products may be more toxic, and the potential for seizures should not be overlooked. The pharmacological action, mechanism of selective insect toxicity, and clinical effects of fipronil are discussed. PMID:12807306

  2. Conservative management of accidental gall bladder puncture during percutaneous nephrolithotomy

    Patil, Nikhil A.; Kundargi, Vinay S.; Patil, Siddangouda B.; Biradar, Ashok N.; Desai, Anup S.

    2014-01-01

    Percutaneous nephrolithotomy (PCNL) has been an excellent option for the management of kidney stones. There have been many complications in regards to solid organ injury during PCNL. Here we discuss an interesting case of 45-year-old woman, who underwent PCNL for right renal staghorn calculus, and had an accidental puncture of the gall bladder. Post operatively, the patient was conservatively managed and recovered well. A small number of cases has been reported until now in literature.

  3. Accidental Sulfur Poisoning in a Group of Holstein Heifers

    Gunn, Moira F.; Baird, John D.; Wilkie, Judith S. Nimmo

    1987-01-01

    Fourteen animals died or were euthanized after toxic levels of elemental sulfur were accidentally fed to a group of 120 Holstein heifers. Dehydration, rumen stasis, tachycardia, and diarrhea were seen along with metabolic acidosis, hypokalemia, and hypochloremia. The majority of deaths occurred from 3 to 10 days after the sulfur was fed to the heifers. Postmortem examination showed rumenitis, acute alveolitis, and renal tubular necrosis. The toxicity of ingested sulfur was attributed to the c...

  4. Fallout: The experiences of a medical team in the care of a Marshallese population accidentally exposed to fallout radiation

    Conard, R.A.

    1991-01-01

    This report presents an historical account of the experiences of the Brookhaven Medical team in the examination and treatment of the Marshallese people following their accidental exposure to radioactive fallout in 1954. This is the first time that a population has been heavily exposed to radioactive fallout, and even though this was a tragic mishap, the medical findings have provided valuable information for other accidents involving fallout such as the recent reactor accident at Chernobyl. Particularly important has been the unexpected importance of radioactive iodine in the fallout in producing thyroid abnormalities.

  5. Fallout: The experiences of a medical team in the care of a Marshallese population accidentally exposed to fallout radiation

    Conard, R.A.

    1991-12-31

    This report presents an historical account of the experiences of the Brookhaven Medical team in the examination and treatment of the Marshallese people following their accidental exposure to radioactive fallout in 1954. This is the first time that a population has been heavily exposed to radioactive fallout, and even though this was a tragic mishap, the medical findings have provided valuable information for other accidents involving fallout such as the recent reactor accident at Chernobyl. Particularly important has been the unexpected importance of radioactive iodine in the fallout in producing thyroid abnormalities.

  6. Fallout: The experiences of a medical team in the care of a Marshallese population accidentally exposed to fallout radiation

    This report presents an historical account of the experiences of the Brookhaven Medical team in the examination and treatment of the Marshallese people following their accidental exposure to radioactive fallout in 1954. This is the first time that a population has been heavily exposed to radioactive fallout, and even though this was a tragic mishap, the medical findings have provided valuable information for other accidents involving fallout such as the recent reactor accident at Chernobyl. Particularly important has been the unexpected importance of radioactive iodine in the fallout in producing thyroid abnormalities

  7. Accidental catheterization of epidural venous plexus: tomographic analysis

    Mariano Paiva Souza

    2016-04-01

    Full Text Available ABSTRACT BACKGROUND AND OBJECTIVES: Inadvertent venous catheterizations occur in approximately 9% of lumbar epidural anesthetic procedures with catheter placement and, if not promptly recognized, can result in fatal consequences. The objective of this report is to describe a case of accidental catheterization of epidural venous plexus and its recording by computed tomography with contrast injection through the catheter. CASE REPORT: A female patient in her sixties, physical status II (ASA, underwent conventional cholecystectomy under balanced general anesthesia and an epidural with catheter for postoperative analgesia. During surgery, there was clinical suspicion of accidental catheterization of epidural venous plexus because of blood backflow through the catheter, confirmed by the administration of a test dose through the catheter. After the surgery, a CT scan was obtained after contrast injection through the catheter. Contrast was observed all the way from the skin to the azygos vein, passing through anterior and posterior epidural venous plexuses and intervertebral vein. CONCLUSION: It is possible to identify the actual placement of the epidural catheter, as well as to register an accidental catheterization of the epidural venous plexus, using computed tomography with contrast injection through the epidural catheter.

  8. Accidental dural puncture rates in UK obstetric practice.

    Gleeson, C M; Reynolds, F

    1998-10-01

    Headache following epidural analgesia is a common cause of complaint, but accidental dural puncture rates vary among hospitals and with techniques. We were therefore interested to discover the extent of audit of dural puncture, the dural puncture rates in those UK centres that kept reliable records, and the techniques they used for detecting the epidural space. Consultants in charge of anaesthetic services to all 257 obstetric units in the UK were sent a questionnaire requesting numbers of obstetric epidurals, techniques used to detect the epidural space and the numbers of accidental dural punctures in the years 1991-1995. Replies were received from 191 respondents (74%) of whom 104 were able to provide some information about dural puncture rates. Dural puncture rate was inversely related to the number of epidurals performed; the highest recorded rate was 3.6% in a unit with 1000. Most respondents did not record the loss of resistance technique used but among those who did, the dural puncture rate using mainly saline was 0.69% and using mainly air was 1.11% (P<0.001). Since accurate patient information is crucial for informed consent, audit needs to be improved in many centres. Though the accidental dural puncture rate may be under-reported in this survey, our data are in agreement with other findings that loss of resistance to saline is safer than loss of resistance to air. PMID:15321187

  9. Pituitary tumors following fallout radiation exposure

    Two pituitary tumors were diagnosed in a small population of Marshallese accidentally exposed to radioactive fallout in 1954. Endocrinologic findings in the exposed population, are reported and the possible relation of the tumors to radiation exposure and thyroid disease is discussed

  10. Severe adverse effects related to dermal exposure to a glyphosate-surfactant herbicide

    Mariager, T P; Madsen, P V; Ebbehøj, N E;

    2013-01-01

    This is a case of severe chemical burns following prolonged accidental exposure to a glyphosate-surfactant herbicide. The patient developed local swelling, bullae and exuding wounds. Neurological impairment followed affecting finger flexion and sensation with reduced nerve conduction. Imaging...