WorldWideScience

Sample records for accessory spleen mimicking

  1. ACCESSORY SPLEEN: A CLINICALLY RELEVANT ANATOMIC ANOMALY

    Prachi Saffar

    2016-02-01

    Full Text Available The purpose of our study is to emphasize on the clinical relevance of the presence of accessory spleen. It is not only a well-documented anatomic anomaly, it holds special significance in the differential diagnosis of intra-abdominal tumours and lymphadenopathy. MATERIALS AND METHODS Thirty male cadavers from North Indian population above the age of 60 yrs. were dissected in the Anatomy Department of FMHS, SGT University, Gurgaon, over a period of 5 yrs. (Sep 2010-Aug 2015 and presence of accessory spleen recorded. Tissue from the accessory spleen was also subjected to routine histological processing and slide prepared by haematoxylin and eosin staining. RESULTS Accessory spleen was present in two cadavers near the splenic hilum. One was 3.9 cm in the long axis and weighed about 48.4 grams, while the other was 1.2 cm in long axis and weighed about 12.5 grams. One had a separate arterial branch from the main splenic artery; that it was splenic tissue was confirmed histologically. DISCUSSION The presence of accessory spleen is considered to be due to embryonic non-fusion of the splenic aggregate with the main mass. CONCLUSION Though accessory spleen in itself pose no clinical problems, its significance cannot be undermined. Surgeons and radiologists are advised to look for and rule out the presence of accessory spleen, especially while evaluating a case of abdominal and perineal pathology, else it may be wrongly diagnosed as malignant tumour or enlarged lymph node leading to grave consequences.

  2. ACCESSORY SPLEEN: A CLINICALLY RELEVANT ANATOMIC ANOMALY

    Prachi Saffar; Amit Kumar; Ankur

    2016-01-01

    The purpose of our study is to emphasize on the clinical relevance of the presence of accessory spleen. It is not only a well-documented anatomic anomaly, it holds special significance in the differential diagnosis of intra-abdominal tumours and lymphadenopathy. MATERIALS AND METHODS Thirty male cadavers from North Indian population above the age of 60 yrs. were dissected in the Anatomy Department of FMHS, SGT University, Gurgaon, over a period of 5 yrs. (Sep 2010-Aug 2015) and presence...

  3. Accessory breast tissue mimicking pedunculated lipoma.

    Husain, Musharraf; Khan, Sabina; Bhat, Ashraf; Hajini, Firdoos

    2014-01-01

    Accessory breast tissue is an uncommon condition which occurs in 0.4-6% of women. It is mostly located in the axilla where it can cause diagnostic difficulty, especially if it is unilateral and large. Usually it is bilateral and presents as an asymptomatic mass during pregnancy or lactation. The diagnosis of ectopic breast tissue is important as it can undergo the same pathological changes that occur in a normal breast, such as mastitis, fibrocystic disease and carcinoma. We present a case of a large right-sided accessory breast in a 32-year-old woman that was clinically diagnosed as pedunculated lipoma. However, subsequent histopathological examination proved it to be an accessory breast tissue with lactational changes. PMID:25006058

  4. Role of nuclear medicine imaging in differential diagnosis of accessory spleens in patients after splenectomy

    More than 10% of healthy population has one or more accessory spleens. The most common location is the hilum of the spleen or area near the tail of the pancreas. The radiological appearance of accessory spleens in oncologic patients who underwent splenectomy can be misinterpreted as a recurrence, especially in the case of compensatory growth of an accessory spleen in successive radiological examinations. We present the cases of three patients who underwent splenectomy for gastric carcinoid, gastric adenocarcinoma and cancer of the left adrenal gland, respectively. CT examination and/or PET-CT scan revealed suspicious findings in the left upper abdomen. In one patient, the dimensional increase of this finding in successive examinations was initially considered suggestive for cancer recurrence. Scintigraphy with 99mTc-nanocolloid was able to confirm the presence of an accessory spleen in all these patients. Splenic scintigraphy is an economical, accessible and accurate tool in differential diagnosis of accessory spleens in patients after splenectomy

  5. Dynamic computed tomography findings of an accessory spleen in the pelvis: a case report.

    Ota, Hiroshi; Ojima, Yasutomo; Sumitani, Daisuke; Okajima, Masazumi

    2016-12-01

    We report the case of a 60-year-old man with an accessory spleen in the pelvis. He visited our outpatient clinic because of abdominal discomfort. Computed tomography (CT) showed an enhanced mass (40 mm in diameter) in the pelvis. Preoperative diagnosis was difficult even after magnetic resonance imaging and colonoscopy. The patient underwent surgery for suspicion of a gastrointestinal stromal tumor or malignant lymphoma of the rectum. Intraoperative findings showed a mass in the pelvis and a long cord-like tissue reaching the mass and arising from the great omentum; the mass was excised. Histopathologic examination indicated that the mass was splenic tissue, and feeding vessels were found in the cord-like tissue, which were determined to be derived from the left gastroepiploic artery and vein. Thus, we diagnosed it as an accessory spleen in the pelvis. An accessory spleen is not rare and can occur anywhere in the abdominal cavity. However, an accessory spleen in the pelvis is an infrequent finding, and only 9 other cases of an accessory spleen in the pelvis have been reported. Therefore, it is very difficult to make a correct diagnosis preoperatively. However, 7 of the 9 cases (77.8 %) of a pelvic accessory spleen had vascular pedicles from the great omentum or splenic hilum as feeding vessels; hence, determining the feeding blood vessels on dynamic CT may be useful for diagnosing an accessory spleen in the pelvis. Additionally, if the accessory spleen is symptomatic or has a vascular pedicle, surgeons should attempt to resect the accessory spleen in the pelvis using minimally invasive laparoscopy. PMID:26970956

  6. Diagnostic difficulties and therapeutic choices in intrapancreatic accessory spleen: case reports

    Massani M; Maccatrozzo P; Morana G; Fabris L; Ruffolo C; Bonariol L; Pauletti B; Bassi N

    2016-01-01

    Marco Massani,1 Paola Maccatrozzo,1 Giovanni Morana,2 Luca Fabris,3 Cesare Ruffolo,1 Luca Bonariol,1 Bruno Pauletti,1 Nicolò Bassi1 1IV Department of Surgery, Regional Center for HPB Surgery, 2Diagnostic and Interventional Radiology, Regional Hospital of Treviso, Treviso, 3Molecular Medicine Department, University Hospital, Padua, Italy Introduction: Accessory spleen has a worldwide prevalence of 10%–30% and is defined as intrapancreatic accessory spleen (IPAS) when it locates w...

  7. Spleen

    After the liver, the spleen is the next major site of phagocytosis. This function of the spleen causes the organ to take up intravenously administered technetium-99m (Tc-99m) sulfur colloid. In addition, the spleen is the principal site for red cell sequestration. As a consequence, selective splenic imaging is possible after intravenous administration of Tc-99m heat-damaged red blood cells. Indications for splenic scintigraphy include evaluation of abdominal trauma, splenomegaly, tumors, and left upper quadrant mass; search for accessory spleen(s) and diaphragmatic eventration or herniation; and assessment of infarction, functional asplenia, polysplenia, and the heterotaxia syndrome

  8. Accessory Navicular Bone Mimicking Navicular Fracture after Ankle Sprain

    Muharrem Çidem; Murat Uludağ; Kerem Gün; Ülkü Akarırmak

    2011-01-01

    An accessory navicular bone (ANB) is present in 10-30% of normal feet. A morphological classification of ANB on the basis of the radiographic appearance distinguishes three types. Most symptomatic ANBs are of type 2. Although the diagnosis and treatment of sprained ankle are generally straightforward, together with an ANB, it might be misdiagnosed as a fracture. We present a 20-year-old male with type 2 ANB who was misdiagnosed as navicular fracture following sprained ankle. Turk J Phys Med...

  9. Diagnostic difficulties and therapeutic choices in intrapancreatic accessory spleen: case reports

    Massani M

    2016-03-01

    Full Text Available Marco Massani,1 Paola Maccatrozzo,1 Giovanni Morana,2 Luca Fabris,3 Cesare Ruffolo,1 Luca Bonariol,1 Bruno Pauletti,1 Nicolò Bassi1 1IV Department of Surgery, Regional Center for HPB Surgery, 2Diagnostic and Interventional Radiology, Regional Hospital of Treviso, Treviso, 3Molecular Medicine Department, University Hospital, Padua, Italy Introduction: Accessory spleen has a worldwide prevalence of 10%–30% and is defined as intrapancreatic accessory spleen (IPAS when it locates within the pancreas. This occasional finding can raise difficulties in differential diagnosis with hypervascular pancreatic lesions, such as pancreatic neuroendocrine tumor. Presentation of cases: We present five cases in which a mass of the pancreatic tail was found on radiologic investigations. The first case was a young female patient who underwent a distal pancreatectomy because of a mass of the pancreatic tail misdiagnosed as a pancreatic neuroendocrine tumor due to its radiologic features on computed tomography and magnetic resonance imaging (MRI (small, ovoidal, and well defined. Misdiagnosis also occurred in the second case, in which an 82-year-old woman was referred to our hospital because of a pancreatic mass of uncertain diagnosis. She also underwent an operation, and pathologic examination showed splenic parenchyma. A correct diagnosis was achieved in the remaining three cases that are still under radiologic monitoring. Discussion: IPAS is a benign entity and therefore does not require surgical treatment. We discuss the best diagnostic options that have recently been experienced, focusing on diffusion-weighted and superparamagnetic iron oxide MRI, which in our experience seem to be the safest and most easily accessible diagnostic tools. Conclusion: We suggest that a multidisciplinary approach should guide the diagnosis. When a pancreatic mass with specific features (round, ovoid, and well defined is detected by computed tomography or MRI, an IPAS should be

  10. Torsion of an accessory spleen: a rare case preoperatively diagnosed and cured by single-port surgery.

    Ozeki, Maiko; Asakuma, Mitsuhiro; Go, Nakai; Ogura, Takeshi; Inoue, Yoshihiro; Shimizu, Tetsunosuke; Hirokawa, Fumitoshi; Yamamoto, Kazuhiro; Hayashi, Michihiro; Narumi, Yoshifumi; Higuchi, Kazuhide; Uchiyama, Kazuhisa

    2015-12-01

    We report a very rare case of acute abdomen caused by torsion of an accessory spleen that was preoperatively diagnosed and cured by single-port surgery. A 31-year-old woman was admitted to our hospital with severe left abdominal pain. Physical examination revealed a left upper quadrant abdominal tenderness with voluntary guarding. Ultrasound demonstrated a well-defined round mass isoechoic to the spleen, measuring 3.0 cm in diameter in the left upper quadrant adjacent to the spleen. A contrast-enhanced CT scan showed a normally enhanced spleen and a 3.0 × 3.0, hypodense, non-enhancing mass anterior to the spleen with a twisted funicular structure. Torsion of an accessory spleen was suspected, and emergency single-port surgery was performed. During surgery, a rounded violet mass measuring 3.0 cm in diameter, suggestive of an accessory spleen, with a 1800° torsion around a long vascular pedicle along the left side of the greater omentum was discovered. The mass was removed and post-operative recovery was uneventful. A review of the literature revealed 26 cases (including ours) of torsion of an accessory spleen in English. Even with the recent advances in radiologic imaging modalities, making a preoperative diagnosis of this is difficult and most cases are diagnosed during laparotomy. This is the first report preoperatively diagnosed and cured by single-port surgery. We decided to start the operation by using a single port, not only for cosmetic reasons for this young female patient, but also for final confirmation of our diagnosis. We believe that single-port laparoscopy is valuable as a diagnostic tool as long as safety is assured for patients with acute abdomen. Although torsion of an accessory spleen is extremely rare, it should be considered in the differential diagnosis of acute abdomen in children and young adults. PMID:26943424

  11. An accessory skull suture mimicking a skull fracture.

    Wiedijk, J E F; Soerdjbalie-Maikoe, V; Maat, G J R; Maes, A; van Rijn, R R; de Boer, H H

    2016-03-01

    This paper describes an investigation of the sudden and unexpected death of a five-and-a-half-month-old boy. As in every Dutch case of sudden unexpected death in infancy (SUDI), a multidisciplinary diagnostic approach was used. This included post-mortem radiography, showing a linear discontinuity of the parietal bone. Originally this was interpreted as a skull fracture, but autopsy indicated no signs of mechanical trauma. Instead the defect was defined as a unilateral accessory suture of the parietal bone. The initial erroneous diagnosis had severe adverse consequences and thus every health care professional or forensic specialist dealing with paediatric mechanical traumas should be cautious of this rare anomaly. PMID:26860068

  12. Torsion of an accessory spleen: a rare case preoperatively diagnosed and cured by single-port surgery

    Ozeki, Maiko; Asakuma, Mitsuhiro; Go, Nakai; Ogura, Takeshi; Inoue, Yoshihiro; Shimizu, Tetsunosuke; Hirokawa, Fumitoshi; Yamamoto, Kazuhiro; Hayashi, Michihiro; Narumi, Yoshifumi; Higuchi, Kazuhide; Uchiyama, Kazuhisa

    2015-01-01

    We report a very rare case of acute abdomen caused by torsion of an accessory spleen that was preoperatively diagnosed and cured by single-port surgery. A 31-year-old woman was admitted to our hospital with severe left abdominal pain. Physical examination revealed a left upper quadrant abdominal tenderness with voluntary guarding. Ultrasound demonstrated a well-defined round mass isoechoic to the spleen, measuring 3.0 cm in diameter in the left upper quadrant adjacent to the spleen. A contras...

  13. Bilateral axillary masses mimicking as accessory breast with multiple fibroadenoma and bilateral gigantomastia in HIV-positive patient.

    Singh, Saumya; Mishra, Anand K; Tewari, S; Kumar, Sanjeev

    2013-01-01

    Accessory breast is a rare entity that can present as asymptomatic masses or can cause symptoms like heaviness, pain, restriction of arm movement and limitation in daily pursuits with allied apprehension and anxiety for the patient. We present a case of bilateral axillary masses mimicking as accessory breast with multiple fibroadenoma in a 28 years, nulliparous, Indian woman who is HIV positive, which proves to be a diagnostic dilemma. Excisional biopsy was diagnostic. The rarity of such cases imposes challenges on the management in terms of diagnosis, prognosis and therapeutic options. PMID:23813993

  14. Accessory lobe of the liver mimicking a mass in the left adrenal gland. A case report

    An accessory lobe of the liver is a rare anomaly which we have diagnosed in a patient by CT. The lesion appeared as a soft-tissue-density mass with the same density as the liver and attached to the liver. Radionuclide liver scintigraphy helped to confirm the diagnosis. The object of this report is to draw attention to this rare entity since it can cause diagnostic confusion. (orig.)

  15. Multiparasitic Infection (Hydatid Cyst of the Spleen and Ascaris Lumbricoides Infestation) Mimicking an Acute Surgical Abdomen – Case Report

    Molnar Călin; Vizitiu Alexandru; Deak Karoly; Russu Cristian; Tudor Adrian; Suciu Bogdan; Stolnicu Simona; Hulub Marius; Molnar Claudiu

    2016-01-01

    Hydatid cyst involving the spleen is a rare clinical condition (0.5-4%). We report a case of multi-parasitic infection in a 62 year old female (hydatid cyst and ascaris lumbricoides infestation), confirmed during surgery. The purpose of the paper is to emphasize on the rare association of the two parasitic infections, affecting two different organs (spleen and jejunum). The combined symptomatology of the two parasites could mimic an acute surgical abdomen.

  16. Ectopic splenic tissues mimicking gastro-intestinal stromal tumour in a patient after splenectomy for a giant epithelial cyst of spleen: A case report

    Chung Kam Man; Lau Hiu Yan Stephanie; Lau Wan Yee

    2015-01-01

    Introduction: Ectopic splenic tissues left after a previous splenectomy can masquerade as a gastro-intestinal stromal tumour (GIST). Presentation of case: Splenectomy was carried out for a 17-year-old girl with a giant epithelial cyst of spleen. Four years later, an upper endoscopy carried out for dyspepsia revealed two sub-mucosal lesions at the posterior wall of the gastric fundus. Computed tomography diagnosed a GIST. At operation, a dump-bell shaped extragastric mass was excised. Histo...

  17. Spleen: development and functional evaluation

    Despite the fact that the spleen has multiple functions, only one has been widely used for evaluation of the organ by imaging techniques (phagocytosis of /sup 99m/Tc sulfur colloid). The usual splenic uptake of this radiocolloid can by used to determine the size, location, and integrity of the organ. A major use of splenic radiocolloid imaging has been in the study of congenital defects. Thus, eventration of the diaphragm, accessory spleens, splenogonadal fusion, the asplenia and polysplenia syndromes, and the wandering spleen are amenable to study by means of intravenously administered radiocolloid. Interference with the splenic uptake of radiocolloid can be either focal or generalized (as in functional asplenia). Imaging of the spleen has a major role in evaluating suspected trauma of the organ and in following its clinical course. The return of splenic function after splenectomy (splenosis or accessory spleens) can be documented by radionuclide imaging, and likely by hematologic techniques when the volume of tissue is sufficiently large. The detection of intrasplenic lesions is important in tumor staging and as an alerting sign to an ongoing process. 96 references

  18. Wandering spleen

    Qazi Shabir

    2004-01-01

    Full Text Available Wandering spleen is a rare clinical entity, characterized by splenic hypermobility that results from elongation or maldevelopment of its suspensary ligaments. The wandering spleen is in constant danger of torsion and infarction. This condition poses a great diagnostic challenge due to lack of awareness and paucity of symptoms. Among adults, it usually occurs in females of childbearing age, the children below ten years of age are other sufferers. The clinical presentation may be acute or chronic; such as asymptomatic abdominal mass, an acute abdomen, or, most commonly, a mass associated with vague abdominal symptoms. Computed tomography and duplex ultrasonography are best diagnostic modalities. The traditional conservative approach carries high risk of infarction leading to splenectomy and postsplenectomy sepsis. Splenopexy is the treatment of choice for all noninfarcted wandering spleens. Splenectomy should only be performed when there is no evidence of splenic blood flow after detorsion of the spleen. The present study, reviews the presentation, course, diagnostic modalities and management options of wandering spleen

  19. Small Engine & Accessory Test Area

    Federal Laboratory Consortium — The Small Engine and Accessories Test Area (SEATA) facilitates testaircraft starting and auxiliary power systems, small engines and accessories. The SEATA consists...

  20. Ultrasonography of sclerosing angiomatoid nodular transformation in the spleen

    2010-01-01

    We report three rare cases of sclerosing angiomatoid nodular transformation(SANT) in the spleen.We compared the conventional and contrast-enhanced ultrasonographic appearance.The conventional sonographic examinations exhibited solitary lesions without common respects,while contrast-enhanced ultrasonography(CEUS) revealed nodular appearance mimicking its pathologic characteristics.It suggests that CEUS can provide morphologic information for diagnosing SANT.

  1. Spleen and Lymphatic System

    ... Help a Friend Who Cuts? Spleen and Lymphatic System KidsHealth > For Teens > Spleen and Lymphatic System Print A A A Text Size What's in ... en español Bazo y sistema linfático The lymphatic system is an extensive drainage network that helps keep ...

  2. Painful accessory navicular

    Lawson, J.P.; Ogden, J.A.; Sella, E.; Barwick, K.W.

    1984-11-01

    The accessory navicular is usually considered a normal anatomic and roentgenographic variant. The term may refer to two distinct patterns. First, a sesamoid bone may be present within the posterior tibial tendon (Type 1); this is anatomically separate from the navicular. Second, an accessory ossification center may be medial to the navicular (Type 2). During postnatal development this is within a cartilaginous mass that is continuous with the cartilage of the navicular. At skeletal maturity the accessory center usually fuses with the navicular to form a curvilinear bone. The Type 2 pattern may be associated with a painful foot, particularly in the athletic adolescent, and should not be arbitrarily dismissed as a roentgenologic variant in the symptomatic patient. The clinical, radiologic, pathologic, and surgical findings in ten cases are reviewed. Roentgenographically the ossicle is triangular or heartshaped. sup(99m)Tc MDP imaging may be of value when the significance of the ossicle is uncertain. Even when the roentgenographic variant is bilateral, increased radionuclide activity occurs only on the symptomatic side. Histologic examination of surgically excised specimens reveals inflammatory chondro-osseous changes in the navicular-accessory navicular synchondrosis compatible with chronic trauma and stress fracture. Nonsurgical treatment with orthotics or cast immobilization produces variable results and resection of the accessory navicular may be the treatment of choice.

  3. The painful accessory navicular

    The accessory navicular is usually considered a normal anatomic and roentgenographic variant. The term may refer to two distinct patterns. First, a sesamoid bone may be present within the posterior tibial tendon (Type 1); this is anatomically separate from the navicular. Second, an accessory ossification center may be medial to the navicular (Type 2). During postnatal development this is within a cartilaginous mass that is continuous with the cartilage of the navicular. At skeletal maturity the accessory center usually fuses with the navicular to form a curvilinear bone. The Type 2 pattern may be associated with a painful foot, particularly in the athletic adolescent, and should not be arbitrarily dismissed as a roentgenologic variant in the symptomatic patient. The clinical, radiologic, pathologic, and surgical findings in ten cases are reviewed. Roentgenographically the ossicle is triangular or heartshaped. sup(99m)Tc MDP imaging may be of value when the significance of the ossicle is uncertain. Even when the roentgenographic variant is bilateral, increased radionuclide activity occurs only on the symptomatic side. Histologic examination of surgically excised specimens reveals inflammatory chondro-osseous changes in the navicular-accessory navicular synchondrosis compatible with chronic trauma and stress fracture. Nonsurgical treatment with orthotics or cast immobilization produces variable results and resection of the accessory navicular may be the treatment of choice. (orig.)

  4. Pseudoplaquetopenia em paciente submetida à esplenectomia de baço acessório: relato de caso Pseudoplaquetopenia en paciente sometida a la esplenectomía de bazo accesorio: relato de caso Pseudothrombocytopenia in a patient undergoing splenectomy of an accessory spleen: case report

    Eduardo Jorge Yamada

    2008-10-01

    the blood was analyzed with citrate, alerting for the risk of erroneously administering blood products. CASE REPORT: This is the case of a 40-year old female patient, ASA II. In 2001 she presented with thrombocytopenia and was referred to a hematologist in Manaus, in the state of Amazonas, Brazil and underwent splenectomy that same year with a diagnosis of idiopathic thrombocytopenic purpura. Since her CBCs continued to show thrombocytopenia, an abdominal ultrasound was done and showed a spherical hypoechoic image, with an echotexture similar to the spleen, measuring 2.0 × 1.7 cm, with well-defined contents (accessory spleen, and a splenectomy was indicated. One hour into the surgery, blood samples were drawn for CBC and chemistry: Hb = 11.3 g.dL-1; Ht = 33.4%; Platelets = 35,000.µL-1; PT = 15.2 (86.0% Activity (INR = 1.09. Due to the minimal blood loss in the surgical field, a new test with citrate was requested to determine the platelet count (results: 138,000 platelets. CONCLUSIONS: The anomalous result of an isolated exam without corresponding clinical signs should not guide the treatment. All exams have a defined percentage of errors and the search for those technical errors can avoid the use of the wrong treatment.

  5. Overview of the Spleen

    ... Women's Health Issues Symptoms General Abdomen & Digestive Bleeding Brain & Nervous System Chest & Respiratory Children's Symptoms Eye Genital & Urinary ALL ... splenic capsule) that supports its blood vessels and lymphatic vessels. The spleen is ... is part of the infection-fighting (immune) system. It produces white blood cells called lymphocytes, which ...

  6. The forgotten organ: Contrast enhanced sonography of the spleen

    Objective: Ultrasound contrast agents in conjunction with contrast specific imaging techniques, are increasingly accepted in clinical use for diagnostic imaging in several organs. Contrast enhanced sonography (CES) of second-generation contrast media have shown a spleen-specific uptake of the microbubble contrast agent. The aim of this review is to illustrate indications for the use of CES in patients with suspected (peri-)splenic pathology. Methods: This review based on the experience of transcutaneous CES in 200 patients with (peri-)splenic pathology diagnosed by B-mode sonography at an internal medicine center. CES studies were performed with a contrast-devoted unit (Acuson, Sequoia, Siemens medical solution) that had contrast-specific, continuous-mode software. A low mechanical index was used. A sulfur hexafluoride-based microbubble contrast medium (Sonovue, Bracco SpA, Milan, Italy) was injected. Results: On our experience, there are several clinical conditions which may show an diagnostic advantage of CES in comparison to B-mode US. CES should be performed to investigate: (1) the perisplenic tumor to diagnose or exclude accessory spleen, (2) the small-sized spleen to diagnose functional asplenia/hyposplenia, (3) the inhomogenous spleen of unknown cause to diagnose focal lesions within the spleen, (4) the incidentally found hypoechoic splenic tumor to diagnose high vascular splenic hemangioma, (5) focal lesions suspect for splenic abscess, hematoma, infarction to confirme diagnosis, and (6) patients with abdominal trauma to diagnose or exclude splenic injuriy. Conclusion: CES is of diagnostic value in several clinical circumstances to diagnose accessory spleen, functional asplenia, small-sized splenic involvement, high vascular splenic hemangioma, and vascular splenic pathology like splenic infarction, splenic abscess, and splenic laceration

  7. The forgotten organ: Contrast enhanced sonography of the spleen

    Goerg, Christian [Medizinische Universitaetsklinik, Baldingerstrasse, 35043 Marburg/Lahn (Germany)], E-mail: goergc@med.uni-marburg.de

    2007-11-15

    Objective: Ultrasound contrast agents in conjunction with contrast specific imaging techniques, are increasingly accepted in clinical use for diagnostic imaging in several organs. Contrast enhanced sonography (CES) of second-generation contrast media have shown a spleen-specific uptake of the microbubble contrast agent. The aim of this review is to illustrate indications for the use of CES in patients with suspected (peri-)splenic pathology. Methods: This review based on the experience of transcutaneous CES in 200 patients with (peri-)splenic pathology diagnosed by B-mode sonography at an internal medicine center. CES studies were performed with a contrast-devoted unit (Acuson, Sequoia, Siemens medical solution) that had contrast-specific, continuous-mode software. A low mechanical index was used. A sulfur hexafluoride-based microbubble contrast medium (Sonovue, Bracco SpA, Milan, Italy) was injected. Results: On our experience, there are several clinical conditions which may show an diagnostic advantage of CES in comparison to B-mode US. CES should be performed to investigate: (1) the perisplenic tumor to diagnose or exclude accessory spleen, (2) the small-sized spleen to diagnose functional asplenia/hyposplenia, (3) the inhomogenous spleen of unknown cause to diagnose focal lesions within the spleen, (4) the incidentally found hypoechoic splenic tumor to diagnose high vascular splenic hemangioma, (5) focal lesions suspect for splenic abscess, hematoma, infarction to confirme diagnosis, and (6) patients with abdominal trauma to diagnose or exclude splenic injuriy. Conclusion: CES is of diagnostic value in several clinical circumstances to diagnose accessory spleen, functional asplenia, small-sized splenic involvement, high vascular splenic hemangioma, and vascular splenic pathology like splenic infarction, splenic abscess, and splenic laceration.

  8. Spinal accessory nerve neurilemmoma

    A neurilemmoma of the spinal accessory nerve extending from the lower brain stem to the high cervical region, without typical jugular foramen syndome is presented. Preoperative diagnosis is difficult but should be considered in the differential diagnosis of a high cervical intradural extramedullary lesion in patients with lower cranial nerve(s) dysfunction. The value of intrathecal and intravenous contrast enhancement computed tomography (CT) myelogram is emphasized. 13 refs.; 3 figs

  9. Torsion of the Wandering Spleen

    Baradaran Hossein

    2009-10-01

    Full Text Available Wandering spleen, defined as a spleen without its usual peritoneal attachments, is a rare entity. We report a 34-year-old woman with acute abdomen due to torsion of the long vascular pedicle of a wandering spleen, displaced in the abdominal cavity, and infarction of the spleen. Wandering spleen was diagnosed by ultrasound and computed tomography (CT scan, and was managed by splenectomy in this patient. Wandering spleen usually occurs in 20 to 40 years old women. The most common presentation is acute abdominal pain, although signs and symptoms vary widely. Due to the risk of splenic infarction, rapid and accurate diagnosis is essential. A confirmatory diagnosis of a wandering spleen depends heavily upon imaging studies such as abdominal ultrasound, abdominal and pelvic CT scanning, nuclear scintigraphy or a liver-spleen scan. Treatment options include splenopexy or splenectomy.

  10. Accessory scrotum in the perineum

    Pananghat A Kumar

    2011-01-01

    Full Text Available A case of accessory scrotum in a 2-day-old male infant is reported because of its rarity. An overview of sequences during the normal development of male external genitalia has been provided and the deranged mechanism resulting in this anomaly has been reviewed with hypotheses regarding etiology of accessory scrotum.

  11. Accessory scrotum in the perineum

    Pananghat A Kumar; Pavai Arunachalam; Kumar, Prasanna N.

    2011-01-01

    A case of accessory scrotum in a 2-day-old male infant is reported because of its rarity. An overview of sequences during the normal development of male external genitalia has been provided and the deranged mechanism resulting in this anomaly has been reviewed with hypotheses regarding etiology of accessory scrotum.

  12. Spinal accessory nerve schwannomas masquerading as a fourth ventricular lesion

    Shyam Sundar Krishnan

    2015-01-01

    Full Text Available Schwannomas are benign lesions that arise from the nerve sheath of cranial nerves. The most common schwannomas arise from the 8 th cranial nerve (the vestibulo-cochlear nerve followed by trigeminal and facial nerves and then from glossopharyngeal, vagus, and spinal accessory nerves. Schwannomas involving the oculomotor, trochlear, abducens and hypoglossal nerves are very rare. We report a very unusual spinal accessory nerve schwannoma which occupied the fourth ventricle and extended inferiorly to the upper cervical canal. The radiological features have been detailed. The diagnostic dilemma was due to its midline posterior location mimicking a fourth ventricular lesion like medulloblastoma and ependymoma. Total excision is the ideal treatment for these tumors. A brief review of literature with tabulations of the variants has been listed.

  13. Accessory Proteins at ERES

    Klinkenberg, Rafael David

    proteins. Together these components co‐operate in cargo‐selection as well as forming, loading and releasing budding vesicles from specific regions on the membrane surface of the ER. Coat components furthermore convey vesicle targeting towards the Golgi. However, not much is known about the mechanisms that...... regulate the COPII assembly at the vesicle bud site. This thesis provides the first regulatory mechanism of COPII assembly in relation to ER‐membrane lipid‐signal recognition by the accessory protein p125A (Sec23IP). The aim of the project was to characterize p125A function by dissecting two main domains...... in the protein; a putative lipid‐associating domain termed the DDHD domain that is defined by the four amino acid motif that gives the domain its name; and a ubiquitously found domain termed Sterile α‐motif (SAM), which is mostly associated with oligomerization and polymerization. We first show, that...

  14. Ultrasonographic findings of accessory breast

    Accessory breast is an ectopic breast tissue from developmental remnants. It sometimes begins to make symptom, pain and swelling, during premenstrual period or pregnancy. For it has been known as a rear condition, it has occasionally misdiagnosed as a abnormal mass, such as lymphadenitis or hidradentis. We have analyzed 52 accessory breast tissues prospectively, to document the characteristic findings of accessory breast. In summary, the characteristic sonographic findings of accessory breast were the presence of breast tissue superficial to the axillary fascia or underlying fascia if not in axilla, resembling the patient's own breast pattern, the presence of converging appearance of dilated ducts, presence of nipple and/or areola, the obliteration of inner wall of dermis, the obliteration of subcutaneous fat layer, and the downward displacement of axillary fascia or underlying fascia if not in axilla without interruption

  15. Ultrasonographic findings of accessory breast

    Oh, Ki Keun; Cho, Jae Hyun; Yoon, Choon Sik; Kim, Mi Hye [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    1993-07-15

    Accessory breast is an ectopic breast tissue from developmental remnants. It sometimes begins to make symptom, pain and swelling, during premenstrual period or pregnancy. For it has been known as a rear condition, it has occasionally misdiagnosed as a abnormal mass, such as lymphadenitis or hidradentis. We have analyzed 52 accessory breast tissues prospectively, to document the characteristic findings of accessory breast. In summary, the characteristic sonographic findings of accessory breast were the presence of breast tissue superficial to the axillary fascia or underlying fascia if not in axilla, resembling the patient's own breast pattern, the presence of converging appearance of dilated ducts, presence of nipple and/or areola, the obliteration of inner wall of dermis, the obliteration of subcutaneous fat layer, and the downward displacement of axillary fascia or underlying fascia if not in axilla without interruption.

  16. Chronic osteomyelitis mimicking sarcoma

    Gulmann, C; Young, O.; Tolan, M.; O’Riordan, D.; Leader, M

    2003-01-01

    This report describes a rare case of chronic osteomyelitis in a 60 year old man mimicking a soft tissue sarcoma. Chronic osteomyelitis is an infrequent cause of a soft tissue mass and is usually diagnosed clinically by a combination of radiology and microbiology. Rarely, COM can mimic a primary bony neoplasm, but this is the first reported case where it mimicked a soft tissue sarcoma. The clinical, radiological, and histological appearances of this case will be discussed.

  17. CT Findings of Malarial Spleens

    Jang, Ji Yeon; Kwon, Jung Hyeok; Kim, Mi Jeong; Rho, Byung Hak; Lee, Mi Young [Keimyung University School of Medicine, Daegu (Korea, Republic of)

    2009-10-15

    The purpose of our study was to evaluate the CT findings of malarial spleens. We reviewed the patient records of 44 patients with malaria during a recent 3.5-year period and we selected 18 patients who underwent an abdominal CT scan. We retrospectively evaluated the CT findings of the malarial spleens and we compared then with those of a control group of 18 men. We analyzed the splenic size, whether or not there was mottled striped splenic enhancement during the arterial phase and the differences of splenic attenuation and the attenuation between the liver and spleen during the precontrast phase, the arterial phase and the portal phase between the two groups. In malarial patients, the spleen was enlarged in all cases (p < 0.001), and splenic attenuation and the degree of enhancement were significantly decreased during the precontrast phase, the arterial phase and the portal phase (p < 0.001). Loss of mottled striped enhancement during the arterial phase was seen in 11 cases (61.1%) (p < 0.001). The attenuation of the spleen was lower than that of the liver in 13 cases (72.2%) during the portal phase (p = 0.003) and in 1 case (5.6%) during the arterial phase (p = 1.000). Splenomegaly, decreased splenic enhancement, the lack of mottled striped enhancement during the arterial phase and lower attenuation than that of the liver during the portal phase are helpful CT findings to diagnose the malarial spleen.

  18. Comparison of murine hepatic accessory cells and splenic dendritic cells

    Accessory cells are required for proliferation and antibody synthesis of B lymphocytes and proliferation of T lymphocytes in primary immune responses in vitro. The obligatory cells derived from the spleen are referred to as dendritic cells. Accessory cells were isolated from normal adult livers which were functionally interchangeable with splenic DC. Both hepatic accessory cells (AC) and splenic DC adhere firmly to plastic culture dishes or wells within 2 hr; but hepatic AC, unlike splenic DC, do not detach during 22 hr additional incubation. Hepatic AC, unlike splenic DC, are not lysed or inactivated by monoclonal antibody 33D1 and C'. Hepatic AC and splenic DC are similarly sensitive to irradiation in vivo and insensitive to irradiation in vitro. Hepatic AC are separated with cells which are predominantly phagocytic and FcR+ and contain nonspecific esterase. Both hepatic AC and splenic DC are suppressed or eliminated by activation of NK cells in vivo, a phenomenon prevented by prior elimination of NK cells

  19. Automobile accessories: Assessment and improvement

    Jackson, M. [Univ. of Nevada, Las Vegas, NV (United States)

    1995-11-01

    With mandates and regulatory policies to meet both the California Air Resources Board (CARB) and the Partnership for a New Generation of Vehicles (PNGV), designing vehicles of the future will become a difficult task. As we look into the use of electric and hybrid vehicles, reduction of the required power demand by influential automobile components is necessary in order to obtain performance and range goals. Among those automobile components are accessories. Accessories have a profound impact on the range and mileage of future vehicles with limited amounts of energy or without power generating capabilities such as conventional vehicles. Careful assessment of major power consuming accessories helps us focus on those that need improvement and contributes to attainment of mileage and range goals for electric and hybrid vehicles.

  20. Results of Clinical Application of Scintillation Scanning of the Spleen on 500 Patients: Possibilities and Limits

    After injecting erythrocytes marked with radioactive substances and artificially damaged there is a rapid clearance of these cells from the blood-stream and sequestration in the spleen. The resultant high concentration of radioactivity in the spleen permits a good scintigraphic demonstration of the organ. For many reasons Na2Cr51O4 seems at present to be the most suitable substance for labelling erythrocytes, and alteration by heat the most practical means of damaging the cells. The systematic application of spleen scintigraphy on over 500 patients showed the following indications for this method: (1) Demonstration of enlargement of the spleen is not possible by clinical or roentgenological methods; (2) Verification of tumours in the upper left abdominal region; (3) Demonstration of accessory spleens after splenectomy; (4) Demonstration of ectopic spleens (situs inversus, ptosis); (5) Demonstration of parenchymal defects in the spleen (e.g. intrasplenic bleeding, infarcts of the spleen, necrosis of the spleen and intrasplenic cysts). By planimetric measurements of the scintigram area and by calculating the ''splenic surface area index'' (= scintigram area/body surface of the patient) a good quantitative estimation of the extent of spleen enlargement may be obtained. In healthy persons the surface area of the scintigram does not exceed 70- 80 cm2 and the splenic surface-area-index lies normally within 2.5 - 4.5 x 10-3. A comparison with the clinical findings showed that only one third of the spleens which were found by scintigraphy to be positively enlarged could be detected by percussion and palpation. In various diseases the clinical estimation.of spleen enlargement is false in an even higher percentage of the cases. Only when the spleen has completely lost the ability to sequestrate heat- altered erythrocytes is the scintigraphic depiction of the spleen impossible. Such cases, however, seem to be extremely rare; we have so far observed only one. Up to now the

  1. Lemierre's Syndrome Mimicking Leptospirosis

    Lin, Dagmar; Suwantarat, Nuntra; Young, Royden S.

    2010-01-01

    Lemierre's syndrome is a suppurative thrombophlebitis involving the internal jugular vein, most commonly associated with Fusobacterium necrophorum, usually a complication of oropharyngeal infections. This syndrome is rare and is often overlooked. We present a case of sepsis mimicking initially severe leptospirosis (Weil's disease) due to acute febrile illness with multiorgan failure and hyperbilirubinemia. Finally, blood cultures revealed Fusobacterium necrophorum and computed tomography (CT)...

  2. Pelvic spleen with uterovaginal prolapse

    A case of wandering (pelvic) spleen associated with third degree uterovaginal prolapse and ascaris in the biliary and intestinal tract is being presented here. On laparotomy; congested splenomegaly was found in the pelvis. Splenectomy, total abdominal hysterectomy and bilateral salpingo-ophrectomy was performed. (author)

  3. Building iPhone OS Accessories

    Maskrey, Ken

    2010-01-01

    This book provides a serious, in-depth look at Apple's External Accessory Framework and the iPhone Accessories API. You'll learn how to create new, integrated solutions that combine iPhone apps with dedicated hardware. The iPhone OS Accessories API expands the opportunities for innovative iPhone developers, allowing you to control and monitor external devices, whether you've built them yourself or obtained them from a third party. What you'll learn * Develop accessories and apps for the iPhone and iPod touch. * Use Apple's External Accessory Framework to create hardware/software interaction. *

  4. Urticaria mimickers in children.

    Mathur, Anubhav N; Mathes, Erin F

    2013-01-01

    Acute urticaria is a self-limited cutaneous condition marked by transient, erythematous, and pruritic wheals. It is a hypersensitivity response that is often secondary to infection, medications, or food allergies in children. In contrast, the urticarial "mimickers" described in this review article are often seen in the context of fever and extracutaneous manifestations in pediatric patients. The differential diagnosis ranges from benign and self-limited hypersensitivity responses to multisystem inflammatory diseases. Establishing the correct diagnosis of an urticarial rash in a pediatric patient is necessary to both prevent an unnecessary work up for self-limited conditions and to appropriately recognize and evaluate multisystem inflammatory disorders. Herein, we describe two cases to illustrate the clinical manifestations, laboratory findings, histopathology and differential diagnoses for several mimickers of acute urticaria including: urticaria multiforme, serum sickness like reaction, Henoch-Schönlein purpura, acute hemorrhagic edema of infancy, systemic onset juvenile idiopathic arthritis, cryopyrin associated periodic syndromes, and urticarial vasculitis. PMID:24552410

  5. Spleen

    ... Thyroid & Parathyroid Glands Adrenal Gland Pancreas Gonads Other Endocrine Glands Review Quiz Cardiovascular System Heart Structure of the Heart Physiology of the Heart Blood Classification & Structure of Blood ...

  6. Mechanical accessories for mobile teleoperators

    The choice of optimum mechanical accessories for mobile teleoperators involves matching the criteria for emergency response with the available technology. This paper presents a general background to teleoperations, a potpourri of the manipulator systems available, and an argument for force reflecting manipulation. The theme presented is that the accomplishment of humanlike endeavors in hostile environments will be most successful when man model capabilities are utilized. The application of recent electronic technology to manipulator development has made new tools available to be applied to emergency response activities. The development activities described are products of the Consolidated Fuel Reprocessing Program at the Oak Ridge National Laboratory. 13 refs., 7 figs

  7. Mechanical accessories for mobile teleoperators

    Feldman, M.J.; Herndon, J.N.

    1985-01-01

    The choice of optimum mechanical accessories for mobile teleoperators involves matching the criteria for emergency response with the available technology. This paper presents a general background to teleoperations, a potpourri of the manipulator systems available, and an argument for force reflecting manipulation. The theme presented is that the accomplishment of humanlike endeavors in hostile environments will be most successful when man model capabilities are utilized. The application of recent electronic technology to manipulator development has made new tools available to be applied to emergency response activities. The development activities described are products of the Consolidated Fuel Reprocessing Program at the Oak Ridge National Laboratory. 13 refs., 7 figs.

  8. Spleen Scintigraphy in Hodgkin's Disease

    The authors give the results of scintigraphic studies carried out on patients suffering from Hodgkin's disease. They first give the technical details of the study, stressing the need for rigorous procedures in corpuscle labelling and alteration, and also the importance of collimation and of scanning at different angles of incidence; they then describe the different morphological characteristics encountered in scanning; in particular, they analyse dimensional and structural attributes of the image; among the latter they distinguish homogeneous and diffuse heterogeneous structures and also heterogeneous structures with gaps. They study these characteristics in relation to the age of the disease and relate them to the clinical and paraclinical context. The changes in the scanning image during treatment are also described and the authors stress the value of the scintigraphic method for checking on the development of splenic symptoms in the course of the disease. Lastly, they discuss the data obtained from analysis of blood and spleen radiation curves and give details on the findings of spleen scintigraphy. (author)

  9. Autosomal Dominant Transmission of Accessory Navicular

    Dobbs, Matthew B.; Walton, Tim

    2004-01-01

    The accessory navicular bone is one of the most symptomatic bones of the foot. Although it has been reported to be present in various members of the same family, there is a lack of knowledge about its inheritance pattern. We report two large pedigrees in which accessory navicular is inherited in an autosomal dominant fashion with incomplete penetrance.

  10. The accessory fallopian tube: A rare anomaly

    Kusum R Gandhi

    2012-01-01

    Full Text Available This paper presents a rare anatomical variation in the form of accessory fallopian tube on right side. The duplication of fallopian tube was observed in a 34-year-old female during routine undergraduate dissection in our department. Fallopian tube is the part of uterus that carries the ovum from the ovary to the uterus. Accessory fallopian tube is the congenital anomaly attached to the ampullary part of main tube. This accessory tube is common site of pyosalpinx, hydrosalpinx, cystic swelling and torsion. The ovum released by the ovary may also be captured by the blind accessory tube leading to infertility or ectopic pregnancy. Hence, all patients of infertility or pelvic inflammatory disease should be screened to rule out the presence of accessory fallopian tube and if encountered should be removed.

  11. Errors made in the ultrasound diagnostics of the spleen.

    Walczyk, Joanna; Walas, Maria Krystyna

    2013-03-01

    Ultrasonography, like any imaging method, entails the risk of errors. From among all means of imaging, it is the most subjective and dependent on the examiner's knowledge and experience. This paper presents the causes of examiner-dependent errors as well as those which result from technical settings and preparation of the patient for the examination. Moreover, the authors discuss the most frequent errors in the diagnosis of splenic conditions, which result from insufficient knowledge concerning anatomical variants of this organ, wrong measurements and incorrect examination technique. The mistakes made in the differentiation of focal lesions of the spleen and its hilum are also discussed. Additionally, the differentiation of collateral circulation, lymph nodes and accessory spleens is mentioned. The authors also draw attention to erroneous interpretation of the left liver lobe as a fragment of the spleen as well as the prominent tail of the pancreas filled with gastric contents and intestinal loops as abnormal masses or fluid cisterns in the area of the splenic hilum. Furthermore, the pathologies of the hilum are discussed such as tumors of the splenic flexure of the colon, lesions arising from the left kidney or the left adrenal gland. The authors list characteristic imaging features of the most common focal lesions visualized in a standard ultrasound scan as well as enhancement patterns appearing in contrast-enhanced examinations. The article discusses the features and differentiation of, among others, infarction, splenic cysts including hydatid ones, abscesses and angiomas. The ultrasound appearance of lymphoma and secondary involvement of the spleen by other malignant neoplasms is also mentioned. Moreover, the authors provide useful tips connected with imaging techniques and interpretation of the findings. The ultrasound examination carried out in compliance with current standards allows for an optimal assessment of the organ and reduction of the error

  12. MORPHOLOGICAL VARIATIONS OF SPLEEN: A CADAVERIC STUDY

    Siva Chidambaram

    2015-07-01

    Full Text Available The Spleen is a large lymphoid organ situated in the left hypochondrial region having an important role in immunological and hematological functions of the human body. The aim of this study was to find the morphological variations of the spleen with respect to it’s a Shape, b Number of notches on its borders and c Presence of anomalous fissure on its surface. The Study was done on 60 formalin fixed cadaveric spleen from the Department of Anatomy, Narayana Medical College, Nellore, Andhra Pradesh. Out of 60 spleens we examined, the various shapes of the spleen were noted suc h as wedge shape (73.33%, triangular (13.33%, tetrahedral (6.67% and oval shape(6.67%.The number of spleen showing notches on its superior border was 38(63.33% and in inferior border it was 6(10%. Absence of splenic notch was observed in 10(16.67% s pleens and the remaining 6 spleens (10% shows notches on its both the borders. The anomalous splenic fissure was found in 4(6.67% spleens on its diaphragmatic surface. The knowledge of variations in the morphology of spleen are essential for physician, s urgeon, radiologist and forensic surgeon to differentiate it from the splenic pathology and splenic injury. In addition to this, it is also important for anatomist during routine classroom dissection and discussion.

  13. Carcinoma in accessory axillary breast.

    Khanna, Seema; Mishra, Shashi Prakash; Kumar, Satendra; Khanna, Ajay Kumar

    2015-01-01

    We present a rare case of carcinoma developing in an accessory breast. The patient presented with a progressive lump in her right axilla for 1 year. On examination, there was a well-developed nipple areola complex in the right axilla overlying a hard, fixed 5 × 3 cm lump. On investigation, core biopsy revealed poorly differentiated carcinoma of the breast. Mammography also revealed features of a malignant lesion with skin and muscle infiltration. Neoadjuvant chemotherapy was administered followed by modified radical mastectomy after three cycles. Immunohistochemistry study showed positive status of oestrogen and progesterone receptors, and negative HER-2 neu. Three more cycles of chemotherapy along with 50 Gy radiotherapy were given in an adjuvant setting followed by hormone therapy. PMID:26260957

  14. Scintillation Scanning of the Spleen with Red Cells Labelled with Cr51

    Satisfactory scintiscans of the spleen have been obtained using chromium-51-labelled red cells, modified by two methods. Initially red cells were sensitized in vitro by coating with incomplete anti-D antibody. In this method the concentration of sensitized red cells in the spleen is proportional to the volume of anti- D serum employed in the sensitization procedure. Satisfactory scintiscans were obtained using 0.50 ml of a 1:128 dilution of anti-D serum, having an original titre of 1: 512/ml of red cells. In spite of good results, the sensitization method, utilizable only in Rh positive patients, has been replaced by the method using red cells modified by heating, which is technically easier and may be used also in Rh negative patients. The image of the spleen is clearly delineated in all the cases, without interference from hepatic radioactivity. The spleen: liver ratio ranges between 5:1 and 10:1. To date scintillation scans of the spleen have been performed in about 60 patients. No immediate or delayed clinical reactions have been observed in the patients after the injection of sensitized or heated red cells. Since the radiation dose delivered to the patient is lower than the dose delivered in many radiological and clinical examinations with radioactive isotopes, the scanning procedure has been widely used in the differential diagnosis of the masses of the left abdomen. Among the cases studied, it is worth while mentioning two cases of splenomegaly associated with a tumour of the left kidney, one case of Banti's disease in a patient, in which a neoplasm of descending colon was suspected and a case of neuroblastomá in a patient two years old, in which the scintiscan of the spleen and that of the kidneys were of great help in making the right diagnosis. Further, the scintiscan has been of unique utility to rule out an accessory spleen and to demonstrate the spleen in congenital malformations, like situs inversus viscerum. In patients affected by chronic leukaemia

  15. Melanocortin receptors and their accessory proteins

    Cooray, Sadani N.; Clark, Adrian J.L.

    2010-01-01

    Abstract The melanocortin receptor family consists of 5 members which belong to the GPCR superfamily. Their specific ligands, the melanocortins are peptide hormones which are formed by the proteolytic cleavage of the proopiomelanocortin (POMC) protein. It is now recognised that certain GPCRs require accessory proteins for their function. Like these GPCRs the melanocortin receptor family is also known to be associated with accessory proteins that regulate their function. ...

  16. [Clinical features of accessory parotid gland tumors].

    Iguchi, Hiroyoshi; Wada, Tadashi; Yamamoto, Hidefumi; Yamada, Kei; Matsushita, Naoki; Okamoto, Sachimi; Teranishi, Yuichi; Koda, Yuki; Kosugi, Yuki; Yamane, Hideo

    2013-12-01

    Accessory parotid gland tumors are relatively rare; hence, adequately detailed clinical analyses of these tumors are difficult to perform at a single institution. In this report, we describe the findings for 65 patients [29 men, 36 women; median age, 51 (9-81) years] with accessory parotid gland tumors, consisting of 4 cases documented by us and 61 cases previously reported by other Japanese authors. Approximately 50% of the patients were treated in an otolaryngology department, while the remaining patients were treated in plastic surgery, oral surgery, or dermatology departments. In 4 patients, the results of preoperative fine-needle aspiration cytology indicated that the tumor was benign; however, the postoperative histopathology results revealed malignant tumors. The frequencies of malignant and benign tumors were 44.6% (n = 29) and 55.4% (n = 36), respectively. Mucoepidermoid carcinoma and pleomorphic adenoma were the most frequent types of malignant and benign accessory parotid gland tumors, respectively. Among the various surgical methods that were used, such as direct cheek and intraoral incisions, a standard parotidectomy incision was the most preferred treatment approach for these tumors. Recently, an endoscopic approach has also been found to yield satisfactory results. An optimal approach should be selected after evaluating the advantages and disadvantages of these methods. No definite guidelines are available regarding the choice of elective neck dissection and postoperative radiation therapy for malignant accessory parotid gland tumors. Although tumor resection (plus elective neck dissection) and postoperative radiation therapy have been frequently performed for various kinds of malignant accessory parotid gland tumors to date, additional studies are needed regarding the criteria for selecting elective neck dissection and postoperative radiation therapy. Since the malignancy rate for accessory parotid gland tumors is higher than that for parotid gland

  17. Changing spleen size after blunt abdominal trauma

    The authors studied the incidence and significance of splenic enlargement on serial CT after abdominal trauma. Spleen size and density in 44 trauma patients were studied with serial, contrast-enhanced Ct. In 58% of the patients, ≥ 10% enlargement of the spleen was seen on follow-up scans. Ten patients had >50% enlargement. In several, the initial density of the spleen was less than that of the liver. Spleen density returned to normal on subsequent scans. Correlations between splenic changes and clinical parameters (such as blood replacement, hypotension, and various trauma indexes) were weak. The author's study indicated that serial splenic enlargement was a physiologic return to normal after major trauma, not a pathologic condition requiring splenectomy

  18. Kawasaki Disease Mimicking Retropharyngeal Abscess

    Srividhya, Vazhkudai Sridharan; Vasanthi, Thiruvengadam; Shivbalan, Somu

    2010-01-01

    Kawasaki disease is an acute, self-limiting febrile mucocutaneous vasculitis of infants and young children. Retropharyngeal lymphadenopathy is a rare presentation of Kawasaki disease. We present a case of Kawasaki disease mimicking a retropharyngeal abscess, with upper airway obstruction resulting in delayed diagnosis. PMID:20635457

  19. Cast functional accessories for heat treatment furnaces

    A. Drotlew

    2010-10-01

    Full Text Available The study gives examples of the cast functional accessories operating in furnaces for the heat treatment of metals and alloys. The describeddesign solutions of castings and their respective assemblies are used for charge preparation and handling. They were put in systematicorder depending on furnace design and the technological purpose of heat treatment. Basic grades of austenitic cast steel, used for castings of this type, were enumerated, and examples of general guidelines formulated for their use were stated. The functional accessories described in this study were designed and made by the Foundry Research Laboratory of West Pomeranian University of Technology.

  20. Computerized tomography examination of injured spleen

    In blunt abdominal injury, the spleen is most frequently injured. A rapid and accurate diagnosis of the injured spleen is therefore of great importance for early and correct therapeutic management. A group is discussed of 56 patients who were examined in the years 1981-1987 after blunt injury of the abdomen by computerized tomography. Computerized tomography is a very useful method which allows rapid and accurate noninvasive diagnosis of different degrees of spleen injury and its possible complications. In comparison with other methods, computerized tomography is the most effective method providing comprehensive information on other organs in the abdominal cavity. It also allows noninvasive examination of severely injured patients and of non-cooperating patients. (author). 6 figs., 1 tab., 15 refs

  1. Biting palsy of the accessory nerve.

    Paljärvi, L; Partanen, J

    1980-01-01

    A young man was bitten by his girl friend at the anterior border of the left trapezius muscle. Weakness of the trapezius resulted and a longstanding ache in the shoulder developed. Clinically and neurophysiologically, an axonotmesis type crush injury of the accessory nerve was verified.

  2. The glossopharyngeal, vagus and spinal accessory nerves

    The glossopharyngeal, vagus and spinal accessory nerves are closely related anatomically, and to a certain extent, functionally. We present an overview of their anatomy, highlighting the important clinical and imaging implications. The main pathologic lesions arising from these nerves are also discussed and the imaging features reviewed.

  3. The glossopharyngeal, vagus and spinal accessory nerves

    Ong, Cheng Kang [Department of Diagnostic Imaging, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore (Singapore)], E-mail: ongck22@hotmail.com; Chong, Vincent Fook Hin [Department of Diagnostic Imaging, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore (Singapore)

    2010-05-15

    The glossopharyngeal, vagus and spinal accessory nerves are closely related anatomically, and to a certain extent, functionally. We present an overview of their anatomy, highlighting the important clinical and imaging implications. The main pathologic lesions arising from these nerves are also discussed and the imaging features reviewed.

  4. 21 CFR 890.3910 - Wheelchair accessory.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Wheelchair accessory. 890.3910 Section 890.3910 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3910...

  5. Mrap2 Accessory Linked to Obesity

    Liu, Tiemin; Elmquist, Joel K.; Williams, Kevin W.

    2013-01-01

    Melanocortin receptors are critical modulators of energy balance and glucose homeostasis. Companion studies published in Science (Asai et al., 2013; Sebag et al., 2013) establish a role for melanocortin receptor accessory protein 2 (Mrap2) in regulating melanocortin receptor activity and in the development of obesity in zebrafish, rodents, and humans.

  6. 21 CFR 878.3925 - Plastic surgery kit and accessories.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Plastic surgery kit and accessories. 878.3925... (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3925 Plastic surgery kit and accessories. (a) Identification. A plastic surgery kit and accessories is a device intended...

  7. 21 CFR 884.6120 - Assisted reproduction accessories.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Assisted reproduction accessories. 884.6120... (CONTINUED) MEDICAL DEVICES OBSTETRICAL AND GYNECOLOGICAL DEVICES Assisted Reproduction Devices § 884.6120 Assisted reproduction accessories. (a) Identification. Assisted reproduction accessories are a group...

  8. 21 CFR 872.3980 - Endosseous dental implant accessories.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Endosseous dental implant accessories. 872.3980... (CONTINUED) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3980 Endosseous dental implant accessories. (a) Identification. Endosseous dental implant accessories are manually powered devices...

  9. Spontaneous rupture of the malarial spleen

    Tauro Leo

    2007-01-01

    Full Text Available Spontaneous rupture of the spleen is a well-described occurrence in many diseases, being most commonly found in malaria. Exact incidence of this complication is not clear. In this article, we discuss pathology, diagnostic approach and therapeutic options in a patient with malarial splenic rupture. Ruptures of malarial spleens do heal and attempts at splenic lavage/conservative approach should be the aim in their management. Splenectomy should be reserved for those patients with severe rupture or those with continued or recurrent bleeding.

  10. Unmasking of the trigemino-accessory reflex in accessory facial anastomosis

    Esteban, A.; Prieto, J.

    1999-01-01

    OBJECTIVE—To evaluate the possible blink reflex responses in facial muscles reinnervated by the accessory nerve.
METHOD—Eleven patients with a complete facial palsy were submitted to a surgical repair by an accessory facial nerve anastomosis (AFA). In this pathological group, blink reflex was studied by means of percutaneous electrical stimulation of the supraorbital nerve and recording from the orbicularis oculi muscle. A control group comprised seven normal people an...

  11. Non‑Azygos Accessory Fissure in Right Upper Lobe Associated with Superior and Inferior Accessory Fissures in Right Lower Lobe

    Thomas Jose Eluvathingal Muttikkal; Chunli Deng

    2012-01-01

    Accessory fissures in the lungs are common congenital variations, usually detected as incidental findings in radiographs or CT scan. Accessory fissures can act as an anatomic barrier to the spread of inflammatory or neoplastic disease, as well as due to the variant anatomy, mimic lesions. It is important to recognize the presence of accessory fissures, as they affect surgical planning of pulmonary lobectomy and segmentectomy. Accessory fissure in the right upper lobe other than due to the ano...

  12. Multicystic Hepatocarcinoma Mimicking Liver Abscess

    Evangelos Falidas

    2013-01-01

    Full Text Available The diagnosis of hepatocellular carcinoma (HCC became easier in relation to the improved radiological examinations; however, the neoplasm may occur under atypical presentations mimicking other benign or malignant processes. Multicystic HCC mimicking a liver abscess associated with septic-type fever and leukocytosis is rare, has a poor prognosis, and poses diagnostic and therapeutic dilemmas. We present the case of an 80-year-old patient, who presented with fever, leukocytosis, and large cystic masses involving right and left lobes of the liver initially considered abscesses and finally diagnosed as HCC after open drainage and liver biopsy. Although the patient died on the tenth postoperative day due to pulmonary oedema, the authors emphasize the high index of suspicion needed in the diagnosis of this unusual presentation of HCC.

  13. Spleen and Lymphatic System (For Parents)

    ... and helps destroy damaged cells. How A Healthy Lymph System Works Carrying Away Waste Lymph fluid drains into lymph capillaries, which are tiny ... is infected. previous continue Problems of the Lymphatic System Certain diseases can affect the lymph nodes, the spleen, or the collections of lymphoid ...

  14. [Strategies for paediatric spleen and liver injuries].

    Zundel, S; Lieber, J; Tsiflikas, I; Henk, A-K; Schmittenbecher, P

    2014-12-01

    Traumatic injuries of the spleen and liver are typically caused by age-related falls or sports and traffic accidents. Today, the non-operative management for isolated injuries is established and evidence-based guidelines are available. The intact abdominal wall and the limited space within the peritoneum produce a compression which is the pathophysiological explanation for the limitation of the haemorrhage. Precondition for the non-operative therapy is the radiology-based classification of the injury (organ injury scale) and a haemodynamically stable patient. Haemodynamic stability is, if necessary maintained with blood transfusion, volume substitutes and the administration of catecholamines. In cases of hilar vascular injury and devascularisation or haemodynamic instability of the patient, despite utilisation of the measures mentioned above, urgent operative therapy needs to be performed. Organ sparing surgery is the therapy of choice for both liver and spleen. The spleen is required for the development of a competent immune system in the growing organism. Liver injuries can be further complicated by injury to the bile system, which might require operative reconstruction. If a patient suffers from multiple injuries and spleen or liver are involved, the decision on the management needs to be taken individually, no guidelines exist but the rate for operative therapy increases. Independent of the dimensions of injury, an experienced paediatric surgeon with his multidisciplinary team, considering the anatomic and age specific characteristics of a child, achieves the best therapeutic results. PMID:25531632

  15. Avermectin induced autophagy in pigeon spleen tissues.

    Liu, Ci; Zhao, Yanbing; Chen, Lijie; Zhang, Ziwei; Li, Ming; Li, Shu

    2015-12-01

    The level of autophagy is considered as an indicator for monitoring the toxic impact of pesticide exposure. Avermectin (AVM), a widely used insecticide, has immunotoxic effects on the pigeon spleen. The aim of this study was to investigate the status of autophagy and the expression levels of microtubule-associated protein1 light chain 3 (LC3), beclin-1, dynein, autophagy associated gene (Atg) 4B, Atg5, target of rapamycin complex 1 (TORC1) and target of rapamycin complex 2 (TORC2) in AVM-treated pigeon spleens. Eighty two-month-old pigeons were randomly divided into four groups: a control group, a low-dose group, a medium-dose group and a high-dose group, which were fed a basal diet spiked with 0, 20, 40 and 60 mg AVM/kg diet, respectively. Microscopic cellular morphology revealed a significant increase in autophagic structures in the AVM-treated groups. The expression of LC3, beclin-1, dynein, Atg4B and Atg5 increased, while mRNA levels of TORC1 and TORC2 were decreased in the AVM-treated groups relative to the control groups at 30, 60 and 90 days in the pigeon spleen. These results indicated that AVM exposure could up-regulate the level of autophagy in a dose-time-dependent manner in the pigeon spleen. PMID:26541719

  16. Impacts of Humanized Mouse Models on the Investigation of HIV-1 Infection: Illuminating the Roles of Viral Accessory Proteins in Vivo

    Eri Yamada

    2015-03-01

    Full Text Available Human immunodeficiency virus type 1 (HIV-1 encodes four accessory genes: vif, vpu, vpr, and nef. Recent investigations using in vitro cell culture systems have shed light on the roles of these HIV-1 accessory proteins, Vif, Vpr, Vpu, and Nef, in counteracting, modulating, and evading various cellular factors that are responsible for anti-HIV-1 intrinsic immunity. However, since humans are the exclusive target for HIV-1 infection, conventional animal models are incapable of mimicking the dynamics of HIV-1 infection in vivo. Moreover, the effects of HIV-1 accessory proteins on viral infection in vivo remain unclear. To elucidate the roles of HIV-1 accessory proteins in the dynamics of viral infection in vivo, humanized mouse models, in which the mice are xenotransplanted with human hematopoietic stem cells, has been utilized. This review describes the current knowledge of the roles of HIV-1 accessory proteins in viral infection, replication, and pathogenicity in vivo, which are revealed by the studies using humanized mouse models.

  17. Alternative delivery of male accessory gland products

    Zizzari, Z Valentina; Smolders, Irene; Koene, Joris M

    2014-01-01

    To increase fertilization success, males transfer accessory gland products (Acps). Several species have evolved unconventional Acps transfer modes, meaning that Acps are transferred separately from the sperm. By surveying the sperm-free Acps transfer cases, we show that these animals have evolved a common strategy to deliver Acps: they all inject Acps directly through the partner’s body wall into the hemolymph. Our review of this mode of Acps transfer reveals another striking similarity: they...

  18. Instruments and accessories for neutron scattering research

    This report describes neutron scattering instruments and accessories installed by four neutron scattering research groups at the ASRC (Advanced Science Research Center) of the JAERI and the recent topics of neutron scattering research using these instruments. The specifications of nine instruments (HRPD, BIX-I, TAS-1 and PNO in the reactor hall, RESA, BIX-II, TAS-2, LTAS and SANS-J in the guide hall of the JRR-3M) are summarized in this booklet. (author)

  19. OVARIAN CALCIFICATION MIMICKING VESICLE CALCULUS

    Pallavi

    2013-04-01

    Full Text Available INTRODUCTION: Calcification in ovary is usually dystrophic in natu re, forming secondary to degeneration of the epithelium or in association wit h areas of necrosis. It may occur in cases of endometriosis [1] or in some ovarian tumor eg. Fibro thecoma [2] , Brenner’s tumor [3] , cavernous hemangioma [4] etc. Benign unilateral densely calcified ovary wit hout any association with tumor or endometriosis has not been reported previously. We report a case of heavily calcified left ovary which mimicked as vesicle calculus on X- ray leading to confusion in diagnosis.

  20. Studies on Prion Replication in Spleen

    Raeber, Alex J.; Fabio Montrasio; Ivan Hegyi; Rico Frigg; Klein, Michael A.; Adriano Aguzzi; Charles Weissmann

    2001-01-01

    Some of the early events following scrapie infection take place in the lymphoreticular system (LRS) and result in significant replication of prions in lymphoid organs. The identity of the cells in the LRS that produce prions and their role in neuroinvasion are still unknown. We find that in the spleen of scrapie-infected mice, prions are associated with T and B cells and to a somewhat lesser degree with the stroma, which contains the follicular dendritic cells (FDC's); curiously, no infectivi...

  1. Malignant fibrous histiocytoma of the spleen

    Šipovac Dragana

    2014-01-01

    Introduction. Since the first description of primary splenic malignant fibrous histiocytoma given by Govoni et al. in 1982, there have been only 18 reported cases by the end of 2013. We herein reported a case of rare primary malignant fibrous histiocytoma of the spleen with liver metastases and unspecific general symptoms. Case Report. A 62-year-old cachectic female complained of sharp strong abdominal pain (on the pain scale 8/10) and distaste for food on ...

  2. Malignant fibrous histiocytoma of the spleen

    Šipovac Dragana

    2014-01-01

    Full Text Available Introduction. Since the first description of primary splenic malignant fibrous histiocytoma given by Govoni et al. in 1982, there have been only 18 reported cases by the end of 2013. We herein reported a case of rare primary malignant fibrous histiocytoma of the spleen with liver metastases and unspecific general symptoms. Case Report. A 62-year-old cachectic female complained of sharp strong abdominal pain (on the pain scale 8/10 and distaste for food on admission at Primary Care Service on March 29, 2014. On physical examination, palpable painful 2 cm long tumefact in the left hypochondriac segment was found. Laboratory findings showed leukocytosis 17.9 x 109/l, erythrocyte sedimentation rate of 55 mm/h, C reactive protein 25.8. Magnetic resonance of abdomen proved secondary deposits in the right liver segment and lower pole of spleen. Positron emission tomography-computed tomography recorded a cold necrosis field in the right liver part and lobulated cystic formation of spleen. After radiological examination, splenectomy and resection of the pancreas cauda were performed. Primary malignant splenic fibrous histiocytoma with liver metastases was proved histopathologically. The patient was given three chemotherapeutic series until October 2, 2014 and she is now in good general condition. Conclusion. The possibility of primary malignant splenic fibrous histiocytoma should be considered in every case with proved intra-abdominal masses of unknown origin. Clinical and laboratory findings are unspecific. Surgical resection with histopathological evaluation is the most effective diagnostic and therapeutic procedure.

  3. Isolated spinal accessory neuropathy and intracisternal schwannomas of the spinal accessory nerve

    Abdullah M. Al-Ajmi

    2015-03-01

    Full Text Available We report a 40-year-old female patient presenting with isolated left spinal accessory neuropathy that developed insidiously over 6 years. She complained of ill-defined deep neck and shoulder pain. On examination, prominent sternocleidomastoid and trapezoid muscle weakness and atrophy, shoulder instability, and lateral scapular winging were observed. MRI identified a small mass of the cisternal portion of the spinal accessory nerve. Its appearance was typical of schwannoma. Surgical treatment was not offered because of the small tumor size, lack of mass effect and the questionable functional recovery in the presence of muscular atrophy.

  4. Imaging of the symptomatic type Il accessory navicular bone

    Accessory ossicles of the foot are commonly mistaken for fractures. The accessory navicular is one of the most common accessory ossicles of the foot. There is a higher incidence in women and the finding might be bilateral in 50-90%. This entity is usually asymptomatic, although populations with medial foot pain have a higher prevalence. Three types of accessory navicular bone have been described. The type Il accessory navicular is the most commonly symptomatic variant with localized chronic or acute on chronic medial foot pain and tenderness with associated inflammation of overlying soft tissues. Plain radiographic identification of the accessory navicular is insufficient to attribute symptomatology. Ultrasound allows for comparison with the asymptomatic side and localization of pain. Bone scintigraphy has a high sensitivity but positive findings lack specificity. Magnetic resonance imaging is of high diagnostic value for demonstrating both bone marrow and soft tissue oedema. Copyright (2004) Blackwell Science Pty Ltd

  5. Imaging of the symptomatic type II accessory navicular bone

    Accessory ossicles of the foot are commonly mistaken for fractures. The accessory navicular is one of the most common accessory ossicles of the foot. There is a higher incidence in women and the finding might be bilateral in 50-90%. This entity is usually asymptomatic, although populations with medial foot pain have a higher prevalence. Three types of accessory navicular bone have been described. The type II accessory navicular is the most commonly symptomatic variant with localized chronic or acute on chronic medial foot pain and tenderness with associated inflammation of overlying soft tissues. Plain radiographic identification of the accessory navicular is insufficient to attribute symptomatology. Ultrasound allows for comparison with the asymptomatic side and localization of pain. Bone scintigraphy has a high sensitivity but positive findings lack specificity. Magnetic resonance imaging is of high diagnostic value for demonstrating both bone marrow and soft tissue oedema Copyright (2004) Blackwell Publishing Asia Pty Ltd

  6. Melanocortin receptor accessory proteins in adrenal disease and obesity

    Jackson, David S.; Ramachandrappa, Shwetha; Clark, Adrian J; Chan, Li F.

    2015-01-01

    Melanocortin receptor accessory proteins (MRAPs) are regulators of the melanocortin receptor family. MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor. The importance of MRAP in adrenal gland physiology is demonstrated by the clinical condition familial glucocorticoid deficiency type 2. The role of its paralog melanocortin-2-receptor accessory protein 2 (MRAP2), which is predominantly expressed in the hypothalamus including the paraventricular nucle...

  7. Black hole mimickers: Regular versus singular behavior

    Black hole mimickers are possible alternatives to black holes; they would look observationally almost like black holes but would have no horizon. The properties in the near-horizon region where gravity is strong can be quite different for both types of objects, but at infinity it could be difficult to discern black holes from their mimickers. To disentangle this possible confusion, we examine the near-horizon properties, and their connection with far away asymptotic properties, of some candidates to black mimickers. We study spherically symmetric uncharged or charged but nonextremal objects, as well as spherically symmetric charged extremal objects. Within the uncharged or charged but nonextremal black hole mimickers, we study nonextremal ε-wormholes on the threshold of the formation of an event horizon, of which a subclass are called black foils, and gravastars. Within the charged extremal black hole mimickers we study extremal ε-wormholes on the threshold of the formation of an event horizon, quasi-black holes, and wormholes on the basis of quasi-black holes from Bonnor stars. We elucidate whether or not the objects belonging to these two classes remain regular in the near-horizon limit. The requirement of full regularity, i.e., finite curvature and absence of naked behavior, up to an arbitrary neighborhood of the gravitational radius of the object enables one to rule out potential mimickers in most of the cases. A list ranking the best black hole mimickers up to the worst, both nonextremal and extremal, is as follows: wormholes on the basis of extremal black holes or on the basis of quasi-black holes, quasi-black holes, wormholes on the basis of nonextremal black holes (black foils), and gravastars. Since in observational astrophysics it is difficult to find extremal configurations (the best mimickers in the ranking), whereas nonextremal configurations are really bad mimickers, the task of distinguishing black holes from their mimickers seems to be less

  8. Accessory slips of the extensor digiti minimi.

    Li, Jing; Mao, Qing Hua

    2014-01-01

    During the educational dissection of a 69-year-old Chinese male cadaver, an extensor digiti minimi (EDM) with five slips on the right hand was discovered. Except for the two slips of the little finger, the two radial slips were inserted into the dorsal aponeurosis of the middle finger and the ring finger, respectively. The middle slip was connected to the junctura tendinum in the fourth intermetacarpal spaces. Variations in this region are of paramount importance for the reconstructive surgeons, who may utilize the accessory slips to restore functional capacity of the fingers. PMID:24970007

  9. Relationship between number of spleen colonies and 125IdUrd incorporation into spleen and femur

    Graded numbers of bone marrow (BM) cells were injected into fatally irradiated mice. Eight days later the mice were given 3.0 μCi (1 Ci = 3.7 x 1010Bq) of 125IdUrd to label proliferating cells in the spleen and BM. On day 9 the mice were killed and the spleens and femurs were removed for splenic colony assay and measurement of radioactivity in the spleen and femurs. The number of splenic colonies shows a linear relationship with dose of marrow cells injected from 104 to 105 cells. The slope of the curve of spleen colonies versus number of cells injected is 5 and below 104 there is a striking departure from the simple linearity. Below 2 x 103 cells injected, the logarithm of the observed colony yield is linear with logarithm of the number of cells injected. Poisson calculation of the average number of pluripotent stem cells that should be present with numbers of marrow cells injected below 2 x 103 followed closely the actual observations. The data show that there is no detectible proliferation in the BM until the dose of marrow cells exceeds 3.5 x 104 cells. Induction of cells into cycle increases the seeding into the BM, and thymidine cytocide drastically reduces seeding in the BM, leading us to conclude that the BM is repopulated almost exclusively by stem cells in DNA synthesis

  10. 21 CFR 876.5090 - Suprapubic urological catheter and accessories.

    2010-04-01

    .... This generic type of device includes the suprapubic catheter and tube, Malecot catheter, catheter punch... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Suprapubic urological catheter and accessories... Suprapubic urological catheter and accessories. (a) Identification. A suprapubic urological catheter...

  11. 14 CFR 23.1437 - Accessories for multiengine airplanes.

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Accessories for multiengine airplanes. 23... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Equipment Miscellaneous Equipment § 23.1437 Accessories for multiengine airplanes. For multiengine...

  12. 21 CFR 876.5630 - Peritoneal dialysis system and accessories.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Peritoneal dialysis system and accessories. 876... Peritoneal dialysis system and accessories. (a) Identification. (1) A peritoneal dialysis system and... peritoneal dialysis, a source of dialysate, and, in some cases, a water purification mechanism. After...

  13. 26 CFR 48.4161(a)-3 - Parts and accessories.

    2010-04-01

    ....4161(a)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) MISCELLANEOUS EXCISE TAXES MANUFACTURERS AND RETAILERS EXCISE TAXES Sporting Goods § 48.4161(a)-3 Parts and accessories. (a) In general. The tax attaches with respect to parts and accessories for articles specified...

  14. Torsion of Pedunculated Accessory Liver Lobe with Acute Acalculous Cholecystitis

    Khandelwal, Kamlesh K.; Gomes, Rachel M.; Bhagvat, Vikrant

    2012-01-01

    Accessory lobes of the liver are very uncommon and rarely symptomatic. We report the occurrence of torsion and infarction of a pedunculated accessory lobe of the liver with acute cholecystitis. The speculated possibilities of the coexistent pathologies and its management are discussed.

  15. MCMV exploits the spleen as a transfer hub for systemic dissemination upon oronasal inoculation.

    Zhang, Shunchuan; Xiang, Jun; Theuns, Sebastiaan; Desmarets, Lowiese M B; Trus, Ivan; Nauwynck, Hans J

    2016-06-01

    Murine cytomegalovirus (MCMV) infection in mice is a commonly used animal model for studying human cytomegalovirus (HCMV) infections. In our previous studies, a mouse model based on an oronasal MCMV infection was set up for mimicking a natural infection, and the spleen was hypothesized to regulate viremia and virus dissemination to distal organs such as submandibular glands. Here, the role of the spleen during an MCMV infection was investigated by the comparison of intact and splenectomized Balb/c mice. Both highly passaged MCMV Smith and low passaged MCMV HaNa1 were used. Various samples were collected at 7, 14, and 21 days post inoculation (dpi) for analyses by virus isolation/titration, co-cultivation and qPCR. The results showed that for both virus strains, 1) cell-associated virus in PBMC (determined by co-cultivation) was detected in intact mice but not in splenectomized mice; 2) the mean viral DNA load in PBMC of splenectomized mice was 4.4-(HaNa1)/2.7-(Smith) fold lower at the peak viremia (7dpi) in contrast to that of intact mice; and 3) infectious virus in the submandibular glands was detected later in splenectomized mice (14dpi) than in intact mice (7dpi). Moreover, the average virus titers in submandibular glands of splenectomized mice were 10-(HaNa1)/7.9-(Smith) fold lower at 14dpi and 1.7-(HaNa1)/2.1-(Smith) fold lower at 21dpi compared with that of intact mice. Upon inoculation with MCMV Smith, infectious virus was found in the kidneys and liver of intact mice, but not in splenectomized mice. Taken together, all these data clearly demonstrate that virus dissemination to distant organs is reduced in splenectomized mice, further confirming the importance of the spleen as a viremia booming site for a natural MCMV infection. PMID:26945848

  16. Acquired vulval lymphangiectases mimicking genital warts

    Sharma Rajeev; Tomar Sudarshan; Chandra Mithilesh

    2002-01-01

    Acquired lymphangiectasia can sometimes occur on the vulva and cause diagnostic difficulties especially if they have a warty appearance. We report a case of acquired vulva I lymphangiectasia which mimicked genital warts.

  17. Acquired vulval lymphangiectases mimicking genital warts

    Sharma Rajeev

    2002-01-01

    Full Text Available Acquired lymphangiectasia can sometimes occur on the vulva and cause diagnostic difficulties especially if they have a warty appearance. We report a case of acquired vulva I lymphangiectasia which mimicked genital warts.

  18. Cerebellopontine angle pilocytic astrocytoma mimicking acoustic schwannoma

    Takada, Y.; Ohno, K.; Tamaki, M.; Hirakawa, K. [Dept. of Neurosurgery, Tokyo Medical and Dental Univ. (Japan)

    1999-12-01

    We describe a case of pilocytic astrocytoma of the cerebellum mimicking an acoustic schwannoma. The tumour protruded into the porus acusticus and enlarged the internal auditory meatus, which is a quite unusual characteristic of glial tumours. (orig.)

  19. Cerebellopontine angle pilocytic astrocytoma mimicking acoustic schwannoma

    We describe a case of pilocytic astrocytoma of the cerebellum mimicking an acoustic schwannoma. The tumour protruded into the porus acusticus and enlarged the internal auditory meatus, which is a quite unusual characteristic of glial tumours. (orig.)

  20. COMPARATIVE ANALISYS OF HEMOSTASIS METHODS IN OPERATIONS ON SPLEEN

    Ye. V. Semichev

    2015-12-01

    Full Text Available The paper provides statistics of spleen traumas, anatomy and characters of the organ damage. The most common methods of spleen hemostasis, currently used in surgical clinics of the Russian Federation, are presented. A small historical excursus about existed methods of hemostasis is given in the paper. A comparative analysis of currently used methods, their advantages and disadvantages is carried out. Some possible criteria for an ideal method of spleen hemostasis are listed as well.

  1. Fluid assisted installation of electrical cable accessories

    Mayer, Robert W.; Silva, Frank A.

    1977-01-01

    An electrical cable accessory includes a generally tubular member of elastomeric material which is to be installed by placement over a cylindrical surface to grip the cylindrical surface, when in appropriate assembled relation therewith, with a predetermined gripping force established by dilation of the tubular member, the installation being facilitated by introducing fluid under pressure, through means provided in the tubular member, between the tubular member and the cylindrical surface, and simultaneously impeding the escape of the fluid under pressure from between the tubular member and the cylindrical surface by means adjacent one of the ends of the tubular member to cause dilation of the tubular member and establish a fluid layer between the tubular member and the cylindrical surface, thereby reducing the gripping force during installation.

  2. Mimicking Portfolios and Exact Arbitrage Pricing.

    Huberman, Gur; Kandel, Shmuel; Robert F. Stambaugh

    1987-01-01

    The authors characterize the sets of mimicking positions whose returns can serve in place of factors in an exact K-factor arbitrage pricing relation for a set of N assets. All of the sets are K-dimensional nonsingular linear transformations of each other. The authors interpret three examples of such transformations and discuss empirical considerations. They also provide conditions under which the mimicking positions can be expressed as portfolios and characterize the relation between mimickin...

  3. Nanofiltration of hormone mimicking trace organic contaminants

    Nghiem, D.L.; Schaefer, Andrea; Elimelech, M.

    2005-01-01

    The removal mechanisms of three hormone mimicking organic compounds by nanofiltration (NF) membranes have been examined. Two NF membranes having different pore size were used in laboratory-scale nanofiltration experiments with feed solutions spiked with a hormone mimicking compound ¾ nonylphenol, tert-butyl phenol, or bisphenol A. Retention of the compounds was determined at various solution chemistries, namely aqueous solution pH, ionic strength, and presence of natural organi...

  4. Tissue mimicking materials for dental ultrasound

    Singh, Rahul S.; Culjat, Martin O.; Grundfest, Warren S.; Brown, Elliott R.; White, Shane N

    2008-01-01

    While acoustic tissue mimicking materials have been explored for a variety of soft and hard biological tissues, no dental hard tissue mimicking materials have been characterized. Tooth phantoms are necessary to better understand acoustic phenomenology within the tooth environment and to accelerate the advancement of dental ultrasound imaging systems. In this study, soda lime glass and dental composite were explored as surrogates for human enamel and dentin, respectively, in terms of compressi...

  5. Bartonella henselae Infection: An Uncommon Mimicker of Autoimmune Disease.

    Maritsi, Despoina N; Zarganis, Diagoras; Metaxa, Zoi; Papaioannou, Georgia; Vartzelis, George

    2013-01-01

    We present a case of a seven-year-old immunocompetent female patient who developed systemic symptoms mimicking an autoimmune rather than an infectious disease. The patient presented with rash, biquotidian fever, night sweats, and arthralgias. There was no antecedent history of cat contact. Investigations showed increased inflammatory markers, leukocytosis, thrombocytosis, hypercalcemia, and raised angiotensin-converting enzyme. Interferon-gamma releasing assay for tuberculosis infection was negative. Abdominal imaging demonstrated multifocal lesions of the liver and spleen (later proved to be granulomata), chest X-ray showed enlarged hilar lymph nodes, and ophthalmology review revealed uveitis. Clinical, laboratory, and imaging features pointed towards sarcoidosis. Subsequently, raised titers (IgM 1 : 32, IgG 1 : 256) against Bartonella confirmed the diagnosis of B. henselae infection. She was treated with gentamycin followed by ciprofloxacin; repeat investigations showed complete resolution of findings. The presence of hepatic and splenic lesions in children with bartonellosis is well documented. Our case, however, exhibited certain unusual findings such as the coexistence of acute ocular and systemic involvement in an immunocompetent host. Serological testing is an inexpensive and effective way to diagnose bartonellosis in immunocompetent patients; we suggest that bartonella serology is included in the baseline tests performed on children with prolonged fever even in the absence of contact with cats in countries where bartonellosis is prevalent. PMID:23424700

  6. Bartonella henselae Infection: An Uncommon Mimicker of Autoimmune Disease

    Despoina N. Maritsi

    2013-01-01

    Full Text Available We present a case of a seven-year-old immunocompetent female patient who developed systemic symptoms mimicking an autoimmune rather than an infectious disease. The patient presented with rash, biquotidian fever, night sweats, and arthralgias. There was no antecedent history of cat contact. Investigations showed increased inflammatory markers, leukocytosis, thrombocytosis, hypercalcemia, and raised angiotensin-converting enzyme. Interferon-gamma releasing assay for tuberculosis infection was negative. Abdominal imaging demonstrated multifocal lesions of the liver and spleen (later proved to be granulomata, chest X-ray showed enlarged hilar lymph nodes, and ophthalmology review revealed uveitis. Clinical, laboratory, and imaging features pointed towards sarcoidosis. Subsequently, raised titers (IgM 1 : 32, IgG 1 : 256 against Bartonella confirmed the diagnosis of B. henselae infection. She was treated with gentamycin followed by ciprofloxacin; repeat investigations showed complete resolution of findings. The presence of hepatic and splenic lesions in children with bartonellosis is well documented. Our case, however, exhibited certain unusual findings such as the coexistence of acute ocular and systemic involvement in an immunocompetent host. Serological testing is an inexpensive and effective way to diagnose bartonellosis in immunocompetent patients; we suggest that bartonella serology is included in the baseline tests performed on children with prolonged fever even in the absence of contact with cats in countries where bartonellosis is prevalent.

  7. Spleen volume on CT and the effect of abdominal trauma.

    Cruz-Romero, Cinthia; Agarwal, Sheela; Abujudeh, Hani H; Thrall, James; Hahn, Peter F

    2016-08-01

    The aim of this study is to determine the magnitude of change in spleen volume on CT in subjects sustaining blunt abdominal trauma without hemorrhage relative to patients without disease and how the spleen volumes are distributed. Sixty-seven subjects with blunt abdominal trauma and 101 control subjects were included in this retrospective single-center, IRB-approved, and HIPAA-compliant study. Patients with an injured spleen were excluded. Using a semiautomatic segmentation program, two readers computed spleen volumes from CT. Spleen volume distribution in male and female trauma and control cohorts were compared nonparametrically. Spleen volume plotted against height, weight, and age were analyzed by linear regression. The number of females and males are, respectively, 35 and 32 in trauma subjects and 69 and 32 among controls. Female trauma patients (49.6 years) were older than males (39.8 years) (p = 0.02). Distributions of spleen volume were not normal, skewed above their means, requiring a nonparametric comparison. Spleen volumes in trauma patients were smaller than those in controls with medians of 230 vs 294 mL in males(p volume correlated positively with weight in females and with height in male controls, and negatively with age in male controls (p volume in controls was 245 mL, the largest ever reported. Spleen volume decreases in response to blunt abdominal trauma. Spleen volumes are not normally distributed. Our population has the largest spleen volume reported in the literature, perhaps a consequence of the obesity epidemic. PMID:27166964

  8. Spleen-preserving distal pancreatectomy with conservation of the spleen vessels

    MA Jin-ping; CHEN Chuang-qi; PENG Lin; ZHAO Gang; CAI Shi-rong; HU Shi-xiong; HE Yu-long; ZHAN Wen-hua

    2011-01-01

    Background Distal pancreatectomy traditionally included splenectomy; the spleen, however, is an important organ in the immunologic defense of the host and is worthy of preservation. The aim of this research was to study the feasibility,safety and clinical effects of spleen and splenic vessel-preserving distal pancreatectomy.Methods A retrospective review was performed for 26 patients undergoing distal pancreatectomy for benign or low grade malignant disease with splenectomy (n=13) or splenic preservation (n=13) at the First Hospital of Sun Yat-sen University and Guangdong General Hospital in Southern China from May 2002 to April 2009.Results All 26 pancreatectomies with splenectomy or splenic preservation were performed successfully. There was no statistically significant difference between two groups in mean operative time ((172±47) minutes vs. (157±52) minutes, P >0.05), intraoperative estimated blood loss ((183±68) ml vs. (160±51) ml, P >0.05), incidence of noninfectious and infection complication and mean length of postoperative hospital stay ((10.1±2.2) days vs. (12.1 ±4.6) days, P >0.05). The platelet counts examined one week after operation were significantly higher in the distal pancreatectomy with splenectomy group than the other group ((37.3±12.8)×109/L vs. (54.7±13.2)×109/L, P <0.05).Conclusions Spleen-preserving distal pancreatectomy appears to be a feasible and safe procedure. In selected cases of benign or low-grade malignant disease, spleen-preserving distal pancreatectomy is recommended.

  9. Giant hydronephrosis mimicking progressive malignancy

    Heidenreich Axel

    2003-10-01

    Full Text Available Abstract Background Cases of giant hydronephroses are rare and usually contain no more than 1–2 litres of fluid in the collecting system. We report a remarkable case of giant hydronephrosis mimicking a progressive malignant abdominal tumour. Case presentation A 78-year-old cachectic woman presented with an enormous abdominal tumour, which, according to the patient, had slowly increased in diameter. Medical history was unremarkable except for a hysterectomy >30 years before. A CT scan revealed a giant cystic tumour filling almost the entire abdominal cavity. It was analysed by two independent radiologists who suspected a tumour originating from the right kidney and additionally a cystic ovarian neoplasm. Subsequently, a diagnostic and therapeutic laparotomy was performed: the tumour presented as a cystic, 35 × 30 × 25 cm expansive structure adhesive to adjacent organs without definite signs of invasive growth. The right renal hilar vessels could finally be identified at its basis. After extirpation another tumourous structure emerged in the pelvis originating from the genital organs and was also resected. The histopathological examination revealed a >15 kg hydronephrotic right kidney, lacking hardly any residual renal cortex parenchyma. The second specimen was identified as an ovary with regressive changes and a large partially calcified cyst. There was no evidence of malignant growth. Conclusion Although both clinical symptoms and the enormous size of the tumour indicated malignant growth, it turned out to be a giant hydronephrosis. Presumably, a chronic obstruction of the distal ureter had caused this extraordinary hydronephrosis. As demonstrated in our case, an accurate diagnosis of giant hydronephrosis remains challenging due to the atrophy of the renal parenchyma associated with chronic obstruction. Therefore, any abdominal cystic mass even in the absence of other evident pathologies should include the differential diagnosis of a

  10. The association of hallux limitus with the accessory navicular.

    Evans, R D Lee; Averett, Ryan; Sanders, Stephanie

    2002-06-01

    Hallux limitus is one of the most prevalent, debilitating disorders of the first metatarsophalangeal joint, and it has many proposed etiologies. This article reviews these etiologies, focusing primarily on the pes planus foot. The pes planus foot type is often associated with symptomatic hallux limitus and the accessory navicular. This article discusses this correlation, although a causal relationship has not been proven. The prevalence and classification of the accessory navicular are also discussed. Clinical cases involving symptomatic hallux limitus occurring concomitantly with an accessory navicular are reviewed, including radiographic findings, symptoms, and surgical treatment. PMID:12070237

  11. Perineal Accessory Scrotum with Congenital Lipoma: A Rare Case Report

    Souvik Chatterjee

    2012-01-01

    Full Text Available A case of accessory scrotum in a 1-year-old boy is reported because of its rarity. A boy presented with a tumor mass attached with scrotum-like skin on its tip in the right side of perineum between the scrotum and anus. Both testes had descended into the scrotum. There was no other urological anomaly. Histological findings of the tumor indicated perineal lipoma, and the scrotum-like portion accessory scrotum. An overview of sequences during the normal development of male external genitalia has been provided and the deranged mechanism resulting in this anomaly has been reviewed with hypothesis regarding etiology of accessory scrotum.

  12. Clinical Application of the Spleen-stomach Theory

    ZHAO Hai-feng

    2004-01-01

    @@ The spleen-stomach theory is a very valuablecomposition of the TCM. It is originated from Neijing (), initiated in Jin-Yuan periods and the idea "spleen and stomach is the postnatal base of life" in Piweilun () written by LI Dong-yuan established its theoretical basis. Directed by this theory, the author cured several cases, and it is now reported below.

  13. Inflammatory pseudotumor of the spleen: A case report

    Selda SEÇKİN; Kübra YILDIRIM

    2008-01-01

    Inflammatory pseudotumors, also known as inflammatory miyofibroblastic tumors, are rare benign tumors of the spleen. The diagnosis of these tumors may be difficult, because they simulate some hematopoetic malignancies, leiomyosarcomas, inflammatory malignant fibrous histiocytoma and inflammatory fibrosclerosing lesions. They frequently occur at lung. But they are reported at gastrointestinal system, orbit, liver, bladder, lymph nodes, heart, brain, mesentery, omentum and spleen. Histologicall...

  14. Study of chicken liver and spleen by Moessbauer spectroscopy

    A preliminary study of purified normal human liver ferritin, normal chicken liver and spleen tissues in lyophilized form showed differences in room temperature Moessbauer hyperfine parameters. An additional study of liver and spleen tissues with lower iron content from chicken with lymphoid leukemia indicated small differences between the quadrupole splittings in these samples compared with those in normal tissues.

  15. 21 CFR 878.1800 - Speculum and accessories.

    2010-04-01

    ...) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Diagnostic Devices § 878.1800 Speculum and accessories.... Class I (general controls). The device is exempt from the premarket notification procedures in subpart...

  16. Accessory Fissures of the liver: CT and sonographic appearance

    Auh, Y.H.; Rubenstein, W.A.; Zirinsky, K.; Kneeland, J.B.; Pardes, J.C.; Engel, I.A.; Whalen, J.P.; Kazam, E.

    1984-09-01

    Invaginations of the liver by the diaphragm form accessory fissures that may mimic the major hepatic fissures on sectional images. Accessory fissures are most common in the superior right hepatic lobe. Their average incidence on computed tomographic (CT) scans is 25%. Their frequency increases with age, approaching 70% in the seventh and eighth decades. Their depth may equal or exceed 2 cm in one-third of cases. Multiple accessory fissures may mimic pathologic liver nodules on CT and may be associated with diaphragmatic scalloping or eventration on the chest film. When only parts of these fissures are seen sonographically, they may be mistaken for echogenic liver lesions. The differentiation of accessory fissures from the major hepatic fissures, from pathologic lesions, and from sonographic pseudofissure artifacts is discussed.

  17. Accessory Fissures of the liver: CT and sonographic appearance

    Invaginations of the liver by the diaphragm form accessory fissures that may mimic the major hepatic fissures on sectional images. Accessory fissures are most common in the superior right hepatic lobe. Their average incidence on computed tomographic (CT) scans is 25%. Their frequency increases with age, approaching 70% in the seventh and eighth decades. Their depth may equal or exceed 2 cm in one-third of cases. Multiple accessory fissures may mimic pathologic liver nodules on CT and may be associated with diaphragmatic scalloping or eventration on the chest film. When only parts of these fissures are seen sonographically, they may be mistaken for echogenic liver lesions. The differentiation of accessory fissures from the major hepatic fissures, from pathologic lesions, and from sonographic pseudofissure artifacts is discussed

  18. PAINFUL ACCESSORY NAVICULAR IN CHILDREN – CASE PRESENTATION

    RE Iacob; Daniela Iacob

    2010-01-01

    Accessory bones, called sesamoid bones, may be occasionally located in the foot. Such a situation is seen in the case of accessory navicular. Its presence is mostly asymptomatic, in some cases in teenagers and adults and more rarely before this age, leading to pains in the leg. This paper presents the case of a 10 year girl experiencing such a pathology that was managed surgically.

  19. Spinal accessory nerve schwannomas masquerading as a fourth ventricular lesion

    Shyam Sundar Krishnan; Sivaram Bojja; Madabhushi Chakravarthy Vasudevan

    2015-01-01

    Schwannomas are benign lesions that arise from the nerve sheath of cranial nerves. The most common schwannomas arise from the 8 th cranial nerve (the vestibulo-cochlear nerve) followed by trigeminal and facial nerves and then from glossopharyngeal, vagus, and spinal accessory nerves. Schwannomas involving the oculomotor, trochlear, abducens and hypoglossal nerves are very rare. We report a very unusual spinal accessory nerve schwannoma which occupied the fourth ventricle and extended inferior...

  20. An incidental finding of the accessory inferior thyroid artery

    Sedy J

    2008-01-01

    We report a case of an incidental finding of the right accessory inferior thyroid artery, emerging from the thyrocervical trunk together with a typical inferior thyroid artery, present in a normal position. On the left side, only single inferior thyroid artery was present. Only one inferior thyroid vein was found on each side. The accessory inferior thyroid artery entered the thyroid gland approximately 1 cm above the normal inferior thyroid, above the superior parathyroid gland. Although acc...

  1. Accessory Nerve Schwannoma Containing Multiple Calcifed Foci: Unusual Presentation

    Leila Aghaghazvini; Habib Mazaher; Hashem Sharifian; Shirin Aghaghazvini

    2009-01-01

    "nIntroduction: Schwannomas are benign neural tumors which arise from the nerve sheath. Schwannomas of the accessory nerve are rare lesions. The clinical presentation of cranial nerve XI schwannomas relates to their location and extent: intracranial, jugular foramen, upper neck, or cervical spine. The extra cranial form is the least common reported. Calcified accessory schwannoma is rare. These lesions most often occur in the third to sixth decades of life. These tumors are slightly more...

  2. Accessory enzymes from Aspergillus involved in xylan and pectin degradation

    Vries, de, G.

    1999-01-01

    The xylanolytic and pectinolytic enzyme systems from Aspergillus have been the subject of study for many years. Although the main chain cleaving enzymes and their encoding genes have been studied in detail, little information is available about most of the accessory enzymes and their corresponding genes. This thesis describes the purification and characterisation of two accessory enzymes from Aspergillus , feruloyl esterase A (FaeA) andα-glucuronidase A (AguA), and the activities of these enz...

  3. Mammographic appearance of accessory breast tissue in the axilla

    Objective: To observe the mammographic appearance of accessory breast tissue in the axilla. Methods: In the past 3 years, 7562 women were underwent bilateral screen-film mammography. All of the mediolateral oblique (MLO) films were reviewed retrospectively to look for whether there was accessory breast tissue and what the mammographic features were like. Radiographically the accessory tissue resembled the main normal breast glandular tissue but was separated from it. Results: Of the 7652 case, accessory breast tissue in the axilla was detected in 161 cases. The prevalence was 2%. The age ranged from 17 to 70 years (mean, 39 years). 38% of them were found in the bilateral axilla, 42% only in the right, and 20% only in the left. The dimensions on the right ranged from 0.7 to 8.0 cm (mean, 3.5 cm), and that on the left ranged from 1.0 to 7.0 cm (mean, 3.3 cm). There were four types among the accessory breast tissue: patchy type was the most (35%), then the branched type (26%), mixed type (20%), and mass-like type (19%). 3 cases were proved by pathology. Conclusion: It is important that the radiologist be familiar with the mammographic appearance of accessory breast tissue in the axilla in order that they could be distinguished from other pathological changes

  4. Malignant fibrous histiocytoma of the spleen: An extremely rare entity

    Leelavathi Dawson; Oneal Gupta; Ketan Garg

    2012-01-01

    Primary malignant fibrous histiocytoma (MFH) of the spleen is extremely rare. Since the first description of primary splenic MFH reported by Govoni et al in 1982, to the best of our knowledge, only twelve cases of MFH of the spleen have been reported in the literature. We herein report a rare case of primary splenic MFH in a 30-year-old Indian male who presented with abdominal pain with a history of recurrent hydatid cyst of liver and spleen. A computed tomography (CT) scan was performed and ...

  5. Peripancreatic fat necrosis mimicking pancreatic cancer

    Thurnher, M.M.; Schima, W.; Turetschek, K.; Thurnher, S.A. [Vienna Univ. (Austria). Inst. fuer Radiologie; Fuegger, R. [Dept. of Surgery, University of Vienna (Austria); Oberhuber, G. [Dept. of Pathology, University of Vienna (Austria)

    2001-06-01

    A case of peripancreatic fat necrosis, after an episode of acute pancreatitis, which mimicked pancreatic cancer with lymph node metastases, is presented. We describe the imaging findings with helical CT scanning and with unenhanced and mangafodipir-enhanced MR imaging, with special emphasis on the differential diagnoses. (orig.)

  6. Diffuse anaplastic leptomeningeal oligodendrogliomatosis mimicking neurosarcoidosis

    Leep Hunderfund, Andrea N.; Zabad, Rana K.; Aksamit, Allen J.; Morris, Jonathan M; Meyer, Fredric B.; Thorell, William E.; Parisi, Joseph E.; Giannini, Caterina

    2013-01-01

    Diffuse leptomeningeal oligodendrogliomatosis is a rare, frequently fatal CNS malignancy that most often affects children.1 Although potentially treatable with chemotherapy and radiation, the radiologic findings are nonspecific and pathologic confirmation of the diagnosis is difficult. We describe an adult patient whose initial presentation mimicked neurosarcoidosis. Despite extensive imaging abnormalities, 3 biopsies were required before the diagnosis of diffuse leptomeningeal oligodendrogli...

  7. Peripancreatic fat necrosis mimicking pancreatic cancer

    A case of peripancreatic fat necrosis, after an episode of acute pancreatitis, which mimicked pancreatic cancer with lymph node metastases, is presented. We describe the imaging findings with helical CT scanning and with unenhanced and mangafodipir-enhanced MR imaging, with special emphasis on the differential diagnoses. (orig.)

  8. Microfilariasis of the breast mimicking malignancy

    Tamojit Chaudhuri; Kamlesh Yadava; Pabitra Ray

    2013-01-01

    We report a 65-year-old female who presented with a 3.5x3 cm retro-areolar lump of the right breast with associated right axillary lymphadenopathy, mimicking breast cancer. Mammography showed a well-defined mass in the central quadrant of the right breast. Fine needle aspiration cytology from the breast lump demonstrated many microfilariae of Wuchereria bancrofti.

  9. Microfilariasis of the breast mimicking malignancy

    Chaudhuri, Tamojit; Yadava, Kamlesh; Ray, Pabitra

    2013-01-01

    We report a 65-year-old female who presented with a 3.5×3 cm retro-areolar lump of the right breast with associated right axillary lymphadenopathy, mimicking breast cancer. Mammography showed a well-defined mass in the central quadrant of the right breast. Fine needle aspiration cytology from the breast lump demonstrated many microfilariae of Wuchereria bancrofti.

  10. Giant Hidroacanthoma Simplex Mimicking Bowen's Disease

    Niiyama, Shiro; Oharaseki, Toshiaki; Mukai, Hideki

    2015-01-01

    Hidroacanthoma simplex is a benign tumor of the skin, macroscopically resembling seborrheic keratosis or Bowen's disease and histologically mimicking clonal-type seborrheic keratosis. We observed a plaque of 70 × 50 mm on the right flank part. From clinical appearance, we suspected Bowen's disease; however, based on immunohistochemical findings, we made a diagnosis of hidroacanthoma simplex.

  11. An adult intussusception mimicking early appendicitis

    Wei-Chun Tseng; Cheng-Ting Hsiao; Yu-Cheng Hung

    2012-01-01

    Adult intussusception is rare with variable clinical presentation. We reported a case of adult intussusception presenting with symptoms mimicking acute appendicitis. The patient presented as an abdominal pain from epigastric area with shifting gradually to RLQ. The atypical presentation of adult intussusception remains a diagnostic challenge to the emergency physician.

  12. The Spleen Revisited: An Overview on Magnetic Resonance Imaging

    João Palas

    2013-01-01

    Full Text Available Despite being well visualized by different cross-sectional imaging techniques, the spleen is many times overlooked during the abdominal examination. The major reason is the low frequency of splenic abnormalities, the majority consisting of incidental findings. There has been a steady increase in the number of performed abdominal magnetic resonance imaging (MRI studies; therefore, it is important to be familiar to the major MRI characteristics of disease processes involving the spleen, in order to interpret the findings correctly, reaching whenever possible the appropriate diagnosis. The spleen may be involved in several pathologic conditions like congenital diseases, trauma, inflammation, vascular disorders and hematologic disorders, benign and malignant tumors, and other disease processes that focally or diffusely affect the spleen. This paper presents a description and representative MRI images for many of these disorders.

  13. Malignant fibrous histiocytoma of the spleen: an extremely rare entity.

    Dawson, Leelavathi; Gupta, Oneal; Garg, Ketan

    2012-01-01

    Primary malignant fibrous histiocytoma (MFH) of the spleen is extremely rare. Since the first description of primary splenic MFH reported by Govoni et al in 1982, to the best of our knowledge, only twelve cases of MFH of the spleen have been reported in the literature. We herein report a rare case of primary splenic MFH in a 30-year-old Indian male who presented with abdominal pain with a history of recurrent hydatid cyst of liver and spleen. A computed tomography (CT) scan was performed and a diagnosis of splenic hydatid cyst was made. Splenectomy was done. On histopathological examination, a diagnosis of malignant mesenchymal tumor, possibly storiform variant of malignant fibrous histiocytoma, was made. On immunohistochemistry, the tumor was positive for vimentin and CD68. The post operative period was uneventful. Compared with the twelve previously cases of MFH of the spleen, our patient is the youngest case reported so far. PMID:22531528

  14. Malignant fibrous histiocytoma of the spleen: An extremely rare entity

    Leelavathi Dawson

    2012-01-01

    Full Text Available Primary malignant fibrous histiocytoma (MFH of the spleen is extremely rare. Since the first description of primary splenic MFH reported by Govoni et al in 1982, to the best of our knowledge, only twelve cases of MFH of the spleen have been reported in the literature. We herein report a rare case of primary splenic MFH in a 30-year-old Indian male who presented with abdominal pain with a history of recurrent hydatid cyst of liver and spleen. A computed tomography (CT scan was performed and a diagnosis of splenic hydatid cyst was made. Splenectomy was done. On histopathological examination, a diagnosis of malignant mesenchymal tumor, possibly storiform variant of malignant fibrous histiocytoma, was made. On immunohistochemistry, the tumor was positive for vimentin and CD68. The post operative period was uneventful. Compared with the twelve previously cases of MFH of the spleen, our patient is the youngest case reported so far.

  15. Inflammatory pseudotumour of the spleen associated with splenic tuberculosis

    Maria; Isabel; Prieto-Nieto; Juan; Pedro; Pérez-Robledo; Beatriz; Díaz-San; Andrés; Manuel; Nistal; José; Antonio; Rodríguez-Montes

    2014-01-01

    Inflammatory pseudotumor(IPT) of the spleen is an uncommon entity with an uncertain aetiology. Inflammatory pseudotumors present diagnostic difficulties because the clinical and radiological findings tend to suggest a malignancy. The symptoms include weight loss, fever, and abdominal pain. Most cases of splenic IPT present solitary relatively large well circumscribed masses on imaging. The diagnosis in the majority of the cases is made after histopathologic study of splenectomy specimens. The IPTs that occur in the spleen and liver are typically associated with Epstein-Barr virus. Thirtyseven percent of all new cases of active tuberculosis infection are extrapulmonary tuberculosis and tuberculous lymphadenitis the most commonly occurring form of extrapulmonary tuberculosis. We report the case of an inflammatory pseudotumor of the spleen associated with splenic tuberculous lymphadenitis in a 50-year-old female patient who was preoperatively diagnosed with a malignant spleen tumour based on her history of breast of carcinoma.

  16. Characterization of murine macrophages from bone marrow, spleen and peritoneum

    Wang Changqi; Yu Xiao; Cao Qi; Wang Ya; Zheng Guoping; Tan Thian Kui; Zhao Hong; Zhao Ye; Wang Yiping; Harris David CH

    2013-01-01

    Abstract Background Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain unclear. In this study, the features of murine macrophages from bone marrow, spleen and peritoneum were compared. Results We found that peritoneal macrophages (PMs) app...

  17. Modification of radioresponse of chick spleen with vitamin E treatment

    Seven days old white leghorn male chicks were exposed to 2.25 Gy whole body gamma radiations with and without vitamin E and studied for histopathological changes in the spleen for a period of twenty eight days postirradiation. The results reveal that the radiation-induced depletion of lymphocytic population in the lymphoid region and the damage to the tissue architecture is comparatively less and reparation of the spleen faster in the vitamin E treated irradiated chicks. (author). 12 refs., 9 figs

  18. Standards of the Polish Ultrasound Society – update. Spleen examination

    Walczyk, Joanna; Walas, Maria Krystyna

    2013-01-01

    Ultrasound scan of the spleen is an integral part of the overall abdominal examination. Due to its anatomical position, physical examination of the spleen is frequently supplemented with an ultrasound which plays a special role in the differential diagnostics of splenic diseases and facilitates the determination of further diagnostic and therapeutic procedures. Similarly to other types of ultrasound scans, the examiner should be familiar with all significant clinical information as well as re...

  19. CT numbers of liver and spleen in normal children

    To determine the mean liver CT numbers, and differences between liver and spleen, and liver and back muscle CT numbers in normal children, and to correlate the findings with sex and age. One hundred and five normal children aged 2-14 years underwent pre-contrast CT scanning. Mean CT numbers of the liver, spleen, and back muscles were calculated, as well as the differences in CT numbers between the liver and spleen (liver-spleen CT numbers), and between the liver-back muscle CT numbers were 70.22±6.51 HU, 53.28±3.57 HU, 17.13±6.57 HU, and 11.88±5.94 HU, respectively. Mean liver CT numbers and the difference between liver and back muscle CT numbers were not different by age. By sex, all the CT numbers did not vary according to age. The sex of a subject did not affect the CT number. The children's mean liver CT number was 70.22±6.51 HU and the difference between liver and spleen CT numbers was 17.13±6.57 HU. Younger children had higher liver CT and liver-spleen CT numbers than older children. No CT numbers varied according to sex

  20. Accessory left gastric artery: angiographic anatomy

    Lee, Kang Soo; Lim, Hyung Guhn; Kim, Hong Soo; Jeon, Doo Sung [Presbyterian Medical Center, Chunju (Korea, Republic of); Chung, Jin Wook; Park, Jae Hyung [College of Medicine and the Institute of Radiation Medicine, Seoul National University, Seoul (Korea, Republic of); Song, Soon Young [Myongji Hospital, College of Medicine, Kwandong University, Seoul (Korea, Republic of)

    2000-09-01

    To evaluate the angiographic anatomy of the accessory left gastric artery (accLGA). We evaluated the angiographic findings of the accLGA in 50 patients (Angiostar; Siemens, Erlangen, Germany). Performing celiac and selective angiography in 50 and 34 patients, respectively. By means of celiac angiography, (1) site of origin, (2) anatomical course, (3) diameter, (4) degree of tortuosity, and (5) distal tapering were evaluated, while selective angiography was used to determine (1) arterial branching, (2) area of blood supply, and (3) patterns of gastric wall stain. Celiac angiography showed that the accLGA arose from the left hepatic artery (LHA) in 45 cases (90%) and from the proper hepatic artery in five (10%). If the accLGA arose from the LHA, its origin entirely depended on the branching pattern of the latter. It always arose from the lateral branch of the LHA furthest to the left and uppermost, and proximal to its umbilical point. The most common anatomical course of the accLGA, seen in 27 cases (54%), was between the S2 and S3 segmental branch. The diameter and degree of tortuosity of the accLGA were similar to those of adjacent intrahepatic branches in 21 (42%) and 33 cases (66%), respectively. The degree of tapering was less than that of adjacent intrahepatic vessel in 28 (56%). Selective angiography demonstrated esophageal branching of the acc LGA in 27 cases (79%), inferior phrenic arterial branching in three (9%), a mediastinal branch in one (3%), and hypervascularity of the lung in one (3%). In 15 cases (44%), bifurcation of the accLGA was recognized. The vascular territory of the accLGA was the gastric fundus together with the distal esophagus in 21 cases (62%), mainly the gastric fundus in six (18%), and mainly the distal esophagus in four (12%). The pattern of gastric mucosal stain was curvilinear wall in 31 cases (91%) and nodular in three (9%). A knowledge of the angiographic anatomy of the accLGA facilitates accurate recognition of this artery on

  1. Modulation of macrophage Ia expression by lipopolysaccharide: Stem cell requirements, accessory lymphocyte involvement, and IA-inducing factor production

    The mechanism of induction of murine macrophage Ia expression by lipopolysaccharide (LPS) was studied. Intraperitoneal injection of 1 microgram of LPS resulted in a 3- to 10-fold increase in the number of IA-positive peritoneal macrophages (flow cytometry and immunofluorescence) and a 6-to 16-fold increase by radioimmunoassay. The isolated lipid A moiety of LPS was a potent inducer of macrophage Ia expression. Ia induction required a functional myelopoietic system as indicated by the finding that the response to LPS was eliminated in irradiated (900 rads) mice and reinstated by reconstitution with bone marrow cells. Comparison of LPS-induced Ia expression in normal and LPS-primed mice revealed a faster secondary response to LPS. The memory response could be adoptively transferred to normal mice with nonadherent spleen cells prepared 60 days after LPS injection. Spleen cells prepared 5 days after LPS injection caused Ia induction in LPS-nonresponder mice; such induction was not observed in irradiated (900 rads) recipients. The cell responsible for this phenomenon was identified as a Thy-1+, immunoglobulin-negative nonadherent cell. The biosynthesis and expression of Ia were not increased by direct exposure of macrophages to LPS in vitro. Small amounts of LPS inhibited Ia induction by gamma interferon. LPS showed positive regulatory effects on Ia expression by delaying the loss of Ia expression on cultured macrophages and by stimulating the production of Ia-inducing factors. Supernatants from cultured spleen cells stimulated with LPS in vitro contained antiviral and Ia-inducing activity that was acid labile, indicating that the active factor is gamma interferon. We conclude that induction of Ia expression by LPS in vivo is a bone-marrow-dependent, radiation-sensitive process which involves the stimulation of a gamma interferon-producing accessory lymphocyte and a delay in Ia turnover

  2. Directly radiolabeled phage with spleen-targeting specificity

    Phage display technique is a powerful approach for discovering new tumor-and organ-targeting ligands, and radiolabeled phage has a potential to analyze the phage-binding sensitivity and specific imaging. In this study, phage II (the spleen-targeting phage) in mice was isolated after three rounds biopanning, and labeled by 99mTc using mercaptoacetyltriglycine (MAG3) as chelator to evaluate their binding properties in vivo. The amount of phage II eluted from spleen was enriched by plague assay each round. 99mTc-MAG3-phage II showed the less retention in blood at any time point than half that of 99mTc-MAG3-phage I (the radiolabeled original Ph. D-12 phage as control). The accumulation in spleen between 99mTc-MAG3-phage I and II was of different tendency. The highest uptake of 99mTc-MAG3-phage II in spleen was 24.80 % ID/g at 30 min; and of 99mTc-MAG3-phage I, 30.93% ID/g at 5 min. After circulating 99mTc-MAG3-phage II for 120 min, its accumulation in spleen decreased though higher than that of 99mTc-MAG3-phage I. In other organs, the 99mTc-MAG3-phage I showed low retention and high spleen-to-organ or tissue ratios. In conclusion, the radiolabeled phage II is convenient for studying the binding and specificity of spleen-targeting peptides found via phage display in vivo. (authors)

  3. Oasissofas: Growing food while mimicking the forests

    Edralin, Don Immanuel; Manuel R. Reyes; Le, K.N.; Izhar, L.; Creason, S.

    2013-01-01

    Water quality in urban areas can be enhanced by biomimicry. In this study, we mimicked the forest by growing vegetables in 6’ x 3’ beds called oasissofas copying a ‘forest ecosystem’ of: continues mulch; minimum soil disturbance – no tillage; and spatial and rotational species diversification. A highly fertilized, compacted and herbicide applied monoculture lawn at the North Carolina Agricultural and Technical State University campus was converted into an experimental site to test if an oasis...

  4. Retroperitoneal Leiomyosarcoma Mimicking Acute Appendicitis: Laparoscopic Management

    Agresta, Ferdinando; De Simone, Paolo; Michelet, Ivan; Bedin, Natalino

    2003-01-01

    Background: Retroperitoneal leiomyosarcomas (RLMS) are a challenging clinical entity. The vast majority of patients are operated on when tumors are advanced. We report herein a case of RLMS, mimicking acute appendiceal disease and treated successfully via laparoscopy. Methods: A 37-year-old woman, para 1, was admitted to our department for right lower quadrant abdominal pain, fever, and leukocytosis. She had no changes in gastrointestinal and urologic function. A physical examination revealed...

  5. Wells Syndrome Mimicking Erythema Elevatum Diutinum

    Rai Ranju; Sharma Vinod Kumar; Kaur Inderjeet; Kumar Bhushan

    2001-01-01

    Wells syndrome is a rare inflammatory dermatosis clinically characterised by recurrent itchy erythematous oedematous plaques with features resembling both urticaria and cellulites and histologically characterised by tissue eosinophilia, oedema and flame figures. Erythema elevatum diutinum(EED) is a chronic localized form of cutaneous vasculitis clinically consisting of symmetrical papules and nodules most often of the back of the hands. We present a case of wells syndrome mimicking EED clini...

  6. Wells Syndrome Mimicking Erythema Elevatum Diutinum

    Rai Ranju

    2001-01-01

    Full Text Available Wells syndrome is a rare inflammatory dermatosis clinically characterised by recurrent itchy erythematous oedematous plaques with features resembling both urticaria and cellulites and histologically characterised by tissue eosinophilia, oedema and flame figures. Erythema elevatum diutinum(EED is a chronic localized form of cutaneous vasculitis clinically consisting of symmetrical papules and nodules most often of the back of the hands. We present a case of wells syndrome mimicking EED clinically.

  7. Acute Myopericarditis Mimicking Acute Myocardial Infarction

    Seval İzdeş; Neriman Defne Altıntaş; Gülin Karaaslan; Recep Uygun; Abdulkadir But

    2011-01-01

    Acute coronary syndromes among young adults are relatively low when compared with older population in the intensive care unit. Electrocardiographic abnormalities mimicking acute coronary syndromes may be caused by non-coronary syndromes and the differential diagnosis requires a detailed evaluation. We are reporting a case of myopericarditis presenting with acute ST elevation and elevated cardiac enzymes simulating acute coronary syndrome. In this case report, the literature is reviewed to dis...

  8. High-altitude cerebral oedema mimicking stroke

    Yanamandra, Uday; Gupta, Amul; Patyal, Sagarika; Varma, Prem Prakash

    2014-01-01

    High-altitude cerebral oedema (HACO) is the most fatal high-altitude illness seen by rural physicians practising in high-altitude areas. HACO presents clinically with cerebellar ataxia, features of raised intracranial pressure (ICP) and coma. Early identification is important as delay in diagnosis can be fatal. We present two cases of HACO presenting with focal deficits mimicking stroke. The first patient presented with left-sided hemiplegia associated with the rapid deterioration in the sens...

  9. A Pilocytic Astrocytoma Mimicking a Clinoidal Meningioma

    Hong, Christopher S.; Lehman, Norman L.; Eric Sauvageau

    2014-01-01

    Pilocytic astrocytomas and meningiomas are benign, primary brain tumors that may involve the optic tract. Classically, the presence of a dural “tail” sign may differentiate a meningioma from other intracranial lesions. In this report, we describe a mass with the typical appearance of a clinoidal meningioma on magnetic resonance imaging (MRI) but postoperatively diagnosed as a pilocytic astrocytoma. This case illustrates the rare occurrence of a pilocytic astrocytoma mimicking a meningioma on ...

  10. 21 CFR 884.6190 - Assisted reproductive microscopes and microscope accessories.

    2010-04-01

    ... HUMAN SERVICES (CONTINUED) MEDICAL DEVICES OBSTETRICAL AND GYNECOLOGICAL DEVICES Assisted Reproduction.... Assisted reproduction microscopes and microscope accessories (excluding microscope stage warmers, which are classified under assisted reproduction accessories) are optical instruments used to enlarge images of...

  11. File list: NoD.Spl.20.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available NoD.Spl.20.AllAg.Spleen mm9 No description Spleen Spleen ERX161929,ERX161935,ERX161...916,ERX161938 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.Spl.20.AllAg.Spleen.bed ...

  12. File list: NoD.Spl.05.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available NoD.Spl.05.AllAg.Spleen mm9 No description Spleen Spleen ERX161938,ERX161929,ERX161...916,ERX161935 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.Spl.05.AllAg.Spleen.bed ...

  13. File list: His.Spl.50.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available His.Spl.50.AllAg.Spleen mm9 Histone Spleen Spleen SRX273304,SRX273305,SRX085459,SRX...RX028524,SRX062979,SRX028526,SRX028528 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.Spl.50.AllAg.Spleen.bed ...

  14. File list: NoD.Spl.50.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available NoD.Spl.50.AllAg.Spleen mm9 No description Spleen Spleen ERX161929,ERX161935,ERX161...916,ERX161938 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.Spl.50.AllAg.Spleen.bed ...

  15. File list: ALL.Spl.10.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available ALL.Spl.10.AllAg.Spleen mm9 All antigens Spleen Spleen SRX997039,SRX119448,SRX11944...70,SRX701168,ERX662615,SRX028526,SRX028528,SRX119447,ERX662625 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.Spl.10.AllAg.Spleen.bed ...

  16. File list: InP.Spl.20.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available InP.Spl.20.AllAg.Spleen mm9 Input control Spleen Spleen ERX662629,ERX662619,SRX2733...X701168,SRX701169,SRX701170,ERX662615,ERX662625 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.Spl.20.AllAg.Spleen.bed ...

  17. File list: Oth.Spl.20.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available Oth.Spl.20.AllAg.Spleen mm9 TFs and others Spleen Spleen SRX143837,SRX062978,SRX119...19447 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.Spl.20.AllAg.Spleen.bed ...

  18. File list: Oth.Spl.50.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available Oth.Spl.50.AllAg.Spleen mm9 TFs and others Spleen Spleen SRX143837,SRX062978,SRX119...19447 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.Spl.50.AllAg.Spleen.bed ...

  19. File list: Oth.Spl.05.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available Oth.Spl.05.AllAg.Spleen mm9 TFs and others Spleen Spleen SRX701159,SRX701155,SRX701...01160 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.Spl.05.AllAg.Spleen.bed ...

  20. File list: InP.Spl.50.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available InP.Spl.50.AllAg.Spleen mm9 Input control Spleen Spleen ERX662629,ERX662619,SRX2733...X701169,SRX701170,ERX662617,ERX662615,ERX662625 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.Spl.50.AllAg.Spleen.bed ...

  1. File list: ALL.Spl.20.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available ALL.Spl.20.AllAg.Spleen mm9 All antigens Spleen Spleen SRX997039,ERX662629,ERX66261...24,SRX062979,SRX028526,SRX028528,ERX662615,ERX662625,SRX119447 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.Spl.20.AllAg.Spleen.bed ...

  2. File list: NoD.Spl.10.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available NoD.Spl.10.AllAg.Spleen mm9 No description Spleen Spleen ERX161938,ERX161929,ERX161...935,ERX161916 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.Spl.10.AllAg.Spleen.bed ...

  3. File list: ALL.Spl.05.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available ALL.Spl.05.AllAg.Spleen mm9 All antigens Spleen Spleen SRX997039,SRX701159,SRX70115...68,SRX701170,SRX701169,ERX662624,ERX662615,SRX028526,ERX662625 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.Spl.05.AllAg.Spleen.bed ...

  4. File list: ALL.Spl.50.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available ALL.Spl.50.AllAg.Spleen mm9 All antigens Spleen Spleen SRX997039,ERX662629,ERX66261...24,SRX062979,SRX028526,SRX028528,ERX662615,ERX662625,SRX119447 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.Spl.50.AllAg.Spleen.bed ...

  5. File list: His.Spl.05.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available His.Spl.05.AllAg.Spleen mm9 Histone Spleen Spleen SRX062984,SRX273302,SRX273305,SRX...RX185791,SRX062983,SRX062979,SRX028526 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.Spl.05.AllAg.Spleen.bed ...

  6. File list: InP.Spl.10.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available InP.Spl.10.AllAg.Spleen mm9 Input control Spleen Spleen ERX662629,ERX662619,ERX5302...X701169,SRX701170,SRX701168,ERX662615,ERX662625 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.Spl.10.AllAg.Spleen.bed ...

  7. File list: His.Spl.10.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available His.Spl.10.AllAg.Spleen mm9 Histone Spleen Spleen SRX273305,SRX062984,SRX273304,SRX...RX028524,SRX062979,SRX028526,SRX028528 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.Spl.10.AllAg.Spleen.bed ...

  8. File list: Oth.Spl.10.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available Oth.Spl.10.AllAg.Spleen mm9 TFs and others Spleen Spleen SRX119448,SRX119446,SRX062...19447 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.Spl.10.AllAg.Spleen.bed ...

  9. File list: His.Spl.20.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available His.Spl.20.AllAg.Spleen mm9 Histone Spleen Spleen SRX273304,SRX273305,SRX085459,SRX...RX028524,SRX062979,SRX028526,SRX028528 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.Spl.20.AllAg.Spleen.bed ...

  10. File list: InP.Spl.05.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available InP.Spl.05.AllAg.Spleen mm9 Input control Spleen Spleen SRX701153,SRX701166,SRX7011...X701170,SRX701169,ERX662624,ERX662615,ERX662625 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.Spl.05.AllAg.Spleen.bed ...

  11. Effects of gold sodium thiomalate on murine spleen cells

    The effects of gold sodium thiomalate (GST) on Balb/c murine spleen cells were investigated using in vitro mitogen blastogenesis techniques. Initial culture of spleen cells in the presence of concanavalin A (Con A) and GST exhibited inhibition of 3H-thymidine uptake due to gold. Spleen cells depleted of monocytes/macrophages by carbonyl iron-ingestion and cultured with Con A and GST demonstrated biphasic effects by gold on thymidine uptake depending upon the Con A and GST concentrations. A final concentration of 2.5 μg/ml con A showed a decreased inhibition of blastogenesis by gold, with macrophage depleted cells as compared to intact spleen cells. While a final concentration of 0.5 μg/ml Con A showed an increased inhibition of blastogenesis by gold with macrophage depleted cells as compared to intact spleen cells. GST was found to be most effective at inhibiting proliferation when present at the initiation of culture. GST was also found to inhibit responsiveness of cells previously incubated with mitogen and its presence in the culture media was required for at least 24-36 hours to produce significant inhibition. These results indicate that the greatest effects of GST on blastogenesis occur during the initial steps of lymphocyte activation and that macrophages may not be the only cell of gold action

  12. SPLEEN CLOSED TRAUMA: SURGICAL TREATMENT VERSUS CONSERVATIVE TREATMENT

    M. Lo Gatto

    2012-01-01

    Full Text Available Introduction. In closed trauma of the most frequent causes of injuries are haemoperitoneus of parenchymatous organs such as liver and spleen. Patients and methods. Clinical Case No.1. R.F. (spleen injury: 2nd degree sec. Moore, 1st degree sec. Buntain WL, Tc-based score of 2 is subject to clinical monitoring with ultrasound control, tc, and several blood exams with a satisfactory clinical outcome. Clinical Case No.2. A.C. presents a clinical picture attributable to 3rd grade sec. Moore and the 2nd grade sec. Buntain WL with a Tc-based score of 4, therefore, performed emergency splenectomy was not delayed, thus saving the patient at the death. Results. The rupture of the spleen is the most frequent complication of closed abdominal trauma (contusion or direct backlash. It appears as isolated lesion in 30-70% of cases. Conclusions. In our experience individual spleen injuries, undercapslular that does not involve the hilum and without spillage of liquid peritoneal deserve a conservative, on the other hand, the spleen injury in excess of 4 cm, manyfragments, with spreading of free peritoneal fluid in need of treatment Surgical sudden.

  13. Antidromic Atrioventricular Reciprocating Tachycardia Using a Concealed Retrograde Conducting Left Lateral Accessory Pathway.

    Gonzalez, Jaime E; Zipse, Matthew M; Nguyen, Duy T; Sauer, William H

    2016-03-01

    Atrioventricular reciprocating tachycardia is a common cause of undifferentiated supraventricular tachycardia. In patients with manifest or concealed accessory pathways, it is imperative to assess for the presence of other accessory pathways. Multiple accessory pathways are present in 4% to 10% of patients and are more common in patients with structural heart disease. In rare cases, multiple accessory pathways can act as the anterograde and retrograde limbs of the tachycardia. PMID:26920167

  14. Forearm soft tissue mass caused by an accessory muscle

    Lopez Milena, G.; Ruiz Santiago, F.; Canadillas Barea, L. [Dept. of Radiology, University Hospital, Granada (Spain); Chamorro Santos, C. [Dept. of Pathology, University Hospital, Granada (Spain)

    2001-08-01

    We present a case of forearm soft tissue mass caused by an accessory muscle, distal and deep to flexor carpi ulnaris muscle. Imaging studies, mainly magnetic resonance and ultrasound, allow a specific diagnosis, and obviate unnecessary surgery. In this case, the symptoms associated with ulnar compression led to surgery and confirmed the preoperative diagnosis. (orig.)

  15. 21 CFR 878.4350 - Cryosurgical unit and accessories.

    2010-04-01

    ... (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Surgical Devices § 878.4350 Cryosurgical unit... to destroy tissue during surgical procedures by applying extreme cold. (2) Cryosurgical unit with a... and accessories is a device intended to destroy tissue during surgical procedures,...

  16. 21 CFR 876.4890 - Urological table and accessories.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Urological table and accessories. 876.4890 Section 876.4890 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Surgical Devices § 876.4890 Urological table...

  17. 21 CFR 876.5130 - Urological catheter and accessories.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Urological catheter and accessories. 876.5130 Section 876.5130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Therapeutic Devices § 876.5130...

  18. Cancer of the accessory breast - a case report

    Breast neoplasm may develop in ectopically located glandular tissue. This paper presents an interesting and rare case of a 50-year-old female who despite regular mammography screening examination developed an invasive accessory breast cancer. Clinical examination revealed a 2 cm - tumour localized 4 cm below the left infra mammary fold. The lesion was immobile, the skin and the atrophic nipple were retracted, the tumour infiltrated the thoracic wall. Oligo biopsy and additional examinations showed an invasive stage IIIB ductal breast cancer (Bloom II, G-2). The receptor status was: ER(+), PGR(+), HER2(-). The increased level of cancer antigen 15.3 was found. The patient was submitted to pre-operative chemotherapy. She also underwent surgery and subsequently post-operative chemotherapy and radiotherapy. On the basis of the presented case, it could be concluded that the accessory mammary glands are out of the image of screening breast examinations. Accessory breast cancer is usually diagnosed by clinical examination and ultrasonography. Preventive resection of accessory breast in women at high risk of developing breast cancer can be considered as the treatment of choice in most patients. (authors)

  19. Accessory thyroid in the anterior mediastinum: case report

    A case of accessory thyroid in the anterior mediastinum, physically separated from the thyroid gland, is reported. The mediastinal thyroid was incidentally discovered during the preoperative evaluation of a patient with breast carcinoma. The extreme rarity of the case is outlined

  20. [Radiofrequency ablation of accessory pathways in pre-excitation syndrome].

    Pfeiffer, D; Tebbenjohanns, J; Jung, W; Manz, M; Lüderitz, B

    1993-04-16

    Various parameters relating to the radio-frequency ablation of accessory pathways were studied in 53 patients (27 males, 26 females: mean age 38.5 [14-64] years) with a history of paroxysmal tachycardia (over 1 month to 50 years), shown to be caused by an accessory pathway (Wolff-Parkinson-White syndrome). In all patients the following values were obtained: (1) number of procedures necessary to achieve permanent blockage of the accessory pathway (1-4); (2) duration of each procedure (45-420 min); (3) duration of fluoroscopy (5-102 min); (4) number of necessary radio-frequency applications (1-48); and (5) cumulative energy per procedure. To ablate left-lateral pathways (n = 10) required fewer procedures, shorter duration per procedure, shorter fluoroscopy time, fewer current applications and less total energy than coagulation of right-sided pathways (n = 10). Those various parameters were greatest for ablation of septal and para-septal pathways (n = 9). Pathways which conducted only retrogradely (n = 15) were more difficult to ablate than those with anterograde conduction (n = 38). There were two complications. In one case a tension pneumothorax occurred after faulty puncture of the subclavian vein; in the other, the left ventricle was perforated causing an acute tamponade which required pericardiocentesis with subsequent suture closure of the perforation. It is concluded that, in principle, all accessory pathways, regardless of their conduction potential and site, can be ablated by a radio-frequency current. PMID:8472633

  1. 76 FR 585 - In the Matter of Certain Handbags, Luggage, Accessories and Packaging Thereof; Notice of...

    2011-01-05

    ... COMMISSION In the Matter of Certain Handbags, Luggage, Accessories and Packaging Thereof; Notice of... States after importation of certain handbags. luggage, accessories and packaging thereof by reason of... certain handbags, luggage, accessories and packaging thereof that infringe the `594 trademark; the...

  2. Littoral-cell angioma of the spleen: A case report

    2007-01-01

    Littoral-cell angioma (LCA) is a primary splenic vascular tumor that arises from the normal littoral cells lining the sinus channels of the splenic red pulp. We report a case of LCA of the spleen, which has been infrequently communicated in the literature. A 76-year-old man with a 2-wk history of weight loss, abdominal pain and changes in bowel habits was admitted to our hospital.Imaging studies (CT and MRI) showed multiple lesions in the spleen. Splenectomy was performed. Lining cells were positive for CD31/CD68 markers. Our case was associated with a serrated colonic adenoma. LCA is a benign vascular tumor of the spleen that needs to be included in the differential diagnosis of multiple splenic nodules.

  3. Clinical application of serial operations with preserving spleen

    Hong-Chi Jiang; Bei Sun; Hai-Quan Qiao; Jun Xu; Da-Xun Piao; Hang Yin

    2001-01-01

    AIM: To evaluate the clinical application of serial operations with preservation of spleen. METHODS: Serial operations with preserving spleen were performed on 211 cases in our hospital from 1980 to 2000.The patient's age ranged from 13 to 56 years, averaging 3years. Diseases included splenic injury in 171 cases, portal hypertension in 9 cases, splenic cyst in 10 cases, and the lesion of pancreatic body and tail in 21 cases. RESULTS: All the cases were cured, and 129 patients were followedup from 3 months to 3 years with the leukocyte phagocytosis test, detection of immunoglubin, CT, 99mTc scanning and ultrasonogrsphy. The results were satisfactory. CONCLUSION: The operations with preserving spleen were safe, feasible, and worth of clinical application.

  4. Candidiasis of the liver and spleen in childhood

    Miller, J.H.; Greenfield, L.D.; Wald, B.R.

    1982-02-01

    Four children with acute leukemia and surgically documented candidiasis of the liver and/or spleen were examined with a combination of diagnostic imaging modalities including /sup 99/mTc-sulfur colloid and /sup 67/Ga-citrate scintigraphy, gray-scale ultrasound, and body computed tomography (CT). Abnormalities were detected in every individual examined. /sup 99/mTc-sulfur colloid scintigraphy revealed cold areas in the liver or spleen. With /sup 67/Ga scintigraphy, these areas were cold in some individuals and hot in others. Gray-scale ultrasound demonstrated hypoechoic lesions with central areas of increased echogenicity in hepatic involvement, and hypoechoic replacement of the spleen in splenic involvement. CT in one patient revealed low-density areas without contrast enhancement within the hepatic parenchyma and unsuspected renal involvement.

  5. Candidiasis of the liver and spleen in childhood

    Four children with acute leukemia and surgically documented candidiasis of the liver and/or spleen were examined with a combination of diagnostic imaging modalities including /sup 99m/Tc-sulfur colloid and /sup 67/Ga- citrate scintigraphy, gray-scale ultrasound, and body computed tomography (CT). Abnormalities were detected in every individual examined. /sup 99m/Tc-sulfur colloid scintigraphy revealed ''cold'' areas in the liver or spleen. With /sup 67/Ga scintigraphy, these areas were ''cold'' in some individuals and ''hot'' in others. Gray-scale ultrasound demonstrated hypoechoic lesions with central areas of increased echogenicity in hepatic involvement, and hypoechoic replacement of the spleen in splenic involvement. CT in one patient revealed low-density areas without contrast enhancement within the hepatic parenchyma and unsuspected renal involvement

  6. Candidiasis of the liver and spleen in childhood

    Miller, J.H. (Childrens Hospital of Los Angeles, CA); Greenfield, L.D.; Wald, B.R.

    1982-02-01

    Four children with acute leukemia and surgically documented candidiasis of the liver and/or spleen were examined with a combination of diagnostic imaging modalities including /sup 99m/Tc-sulfur colloid and /sup 67/Ga- citrate scintigraphy, gray-scale ultrasound, and body computed tomography (CT). Abnormalities were detected in every individual examined. /sup 99m/Tc-sulfur colloid scintigraphy revealed ''cold'' areas in the liver or spleen. With /sup 67/Ga scintigraphy, these areas were ''cold'' in some individuals and ''hot'' in others. Gray-scale ultrasound demonstrated hypoechoic lesions with central areas of increased echogenicity in hepatic involvement, and hypoechoic replacement of the spleen in splenic involvement. CT in one patient revealed low-density areas without contrast enhancement within the hepatic parenchyma and unsuspected renal involvement.

  7. CT findings in children with blunt trauma in the spleen

    We evaluated CT findings in 19 children with blunt injuries in the spleen. CT demonstrated laceration of the spleen in 7 children, rupture of the spleen in 7, and splenic hematoma in 5. Leakage of the contrast medium was observed in 3 children, of whom 1 was treated by arterial embolization. Laparotomy was performed in 3 children (15.8%) other than the 3 showing contrast medium leakage; hemostasis by compression was performed in 1 with laceration, and splenectomy in 2 with rupture. Late splenic rupture or abscess did not occur in any child. One child (5.3%) died of complicating injuries. Many of children with blunt splenic injuries can be successfully treated with conservative treatment, and CT scanning is useful for evaluating the degree of splenic injuries and complicating injuries. (author)

  8. Human spleen microanatomy: why mice do not suffice.

    Steiniger, Birte S

    2015-07-01

    The microanatomical structure of the spleen has been primarily described in mice and rats. This leads to terminological problems with respect to humans and their species-specific splenic microstructure. In mice, rats and humans the spleen consists of the white pulp embedded in the red pulp. In the white pulp, T and B lymphocytes form accumulations, the periarteriolar lymphatic sheaths and the follicles, located around intermediate-sized arterial vessels, the central arteries. The red pulp is a reticular connective tissue containing all types of blood cells. The spleen of mice and rats exhibits an additional well-delineated B-cell compartment, the marginal zone, between white and red pulp. This area is, however, absent in human spleen. Human splenic secondary follicles comprise three zones: a germinal centre, a mantle zone and a superficial zone. In humans, arterioles and sheathed capillaries in the red pulp are surrounded by lymphocytes, especially by B cells. Human sheathed capillaries are related to the splenic ellipsoids of most other vertebrates. Such vessels are lacking in rats or mice, which form an evolutionary exception. Capillary sheaths are composed of endothelial cells, pericytes, special stromal sheath cells, macrophages and B lymphocytes. Human spleens most probably host a totally open circulation system, as connections from capillaries to sinuses were not found in the red pulp. Three stromal cell types of different phenotype and location occur in the human white pulp. Splenic white and red pulp structure is reviewed in rats, mice and humans to encourage further investigations on lymphocyte recirculation through the spleen. PMID:25827019

  9. Effect of ionizing radiation on cell death in frog spleen

    It was studied the number of dead cells in frog spleen by means of coloration with trypan blue which allowed to estimate last stage of apoptosis dead of cells.The investigated frogs (Rana arvalis) were caught in september 1997 at radionuclide contamination territory (the Gomel Region, the Khojniki District). Control animals were caught in village Ratamka of the Minsk District. The percent of dead cells was less in control group in 1,5 times. Under additional irradiation (2 Gy) the number of dead cells in spleen also differs significantly in the investigated and control groups

  10. Difference in gene expression of macrophage between normal spleen and portal hypertensive spleen idendified by cDNA microarray

    Feng Yan; Xiao-Min Wang

    2007-01-01

    AIM: To identify the difference in gene expression of microphage (Mφ) between normal spleen and portal hypertensive spleen using cDNA microarrays and find new gene functions associated with hypersplenism in portal hypertension.METHODS: The Biostar-H140s chip containing 14112 spots of cDNAs were used to investigate the difference of the expression. The total RNA extracted from macrophages isolated from both normal spleen and portal hypertensive spleen was reversely transcribed to cDNA with the incorporation of fluorescent (cy3 and cy5) labeled dCTP to prepare the hybridization probes.After hybridization, the gene chip was scanned for the fluorescent intensity. The differentially expressed genes were screened. That was repeated three times,and only the genes which had differential expression in all three chips were considered to be associated with hypersplenism in portal hypertension.RESULTS: Eight hundred and ninety-six, 1330 and 898 genes were identified to be differentially expressed in three chips, respectively. One hundred and twenty-one genes (0.86%) were identified to be differentially expressed in all three chips, including 21 up-regulated genes and 73 down-regulated genes. The differentially expressed genes were related to ionic channel and transport protein, cyclin, cytoskeleton, cell receptor, cell signal conduct, metabolism, immune, and so on. These genes might be related to the hypersplenism in portal hypertension.CONCLUSION: The investigations based on cDNA microarray can screen differentially expressed genes of macrophages between normal spleen and portal hypertensive spleen, thus may provide a new idea in studying the pathogenesis of hypersplenism in portal hypertension.

  11. Study on reduction of accessory horsepower requirements. Eleventh quarterly progress report

    1977-04-30

    Progress in a program for optimizing automotive accessory systems to achieve greater vehicle fuel economy and improved accessory performance is reported. The major technical accomplishments during this reporting period were: all candidate advanced air conditioning concepts were evaluated; advanced air conditioning and hybrid accessory drive component trade-studies were completed; improved alternator, water pump and power steering system concepts were evaluated; the vehicle integrated accessory systems trade-study was completed; and the technical summary report for the Phase V Automotive Accessory Systems Optimization Program was initiated. (LCL)

  12. Hypertrophic Nonunion Humerus Mimicking an Enchondroma

    N. K. Magu

    2014-01-01

    Full Text Available Introduction. Although fractures of humeral shaft show excellent results with conservative management, nonunion does occur. Case Report. We bring forth the case of a young male with a 1.5-year-old hypertrophic nonunion of the humerus mimicking an enchondroma. The initial X-ray images of the patient appeared to be an enchondroma, which only on further evaluation and histopathological analysis was diagnosed conclusively to be a hypertrophic nonunion. Discussion. Enchondromas are often incidentally diagnosed benign tumours. It is however not common to misdiagnose a hypertrophic nonunion to be an enchondroma. We present this case to highlight the unique diagnostic dilemma the treating team had to face.

  13. Benzalkonium Chloride Intoxication Mimicking Herpes Zoster Encephalitis

    Ekrem Güler

    2011-06-01

    Full Text Available Benzalkonium chloride (BAC is a frequently used disinfectant and its most well-known side effect is contact dermatitis. In this report, two children who had vesicular dermatitis, headache, lethargy, fever and encephalopathy mimicking Herpes zoster encephalitis were presented. Their consciousness level improved on the second day. From the medical history it was understood that the mother had applied 20% BAC solution to the scalps of two children. The aim of the presentation of this report is to draw attention to the fact that BAC application to the scalp for treating pediculosis capitis may resemble the herpes encephalitis clinical picture.

  14. Actinomycosis mimicking recurrent carcinoma after Whipple's operation

    Jun-Te Hsu; Hung-Chieh Lo; Yi-Yin Jan; Han-Ming Chen

    2005-01-01

    Actinomycosis is a rare, chronic, spreading, suppurative,granulomatous and fibrosing infection. Actinomyces are normal inhabitants of the oral cavity and gastrointestinal tract. They rarely cause disease and are seldom reported as pathogens. Herein, we reported on a 69-year-old male patient who had undergone Whipple's operation due to ampulla Vater carcinoma, and became infected with actinomycosis at the pancreaticojejunostomy, which mimicked a recurrent malignancy. He was treated with radical resection of the mass at the pancreaticojejunostomy and had an uneventful postoperative course.

  15. Pulmonary lesions mimicking pericardial effusion on ultrasonography

    Two children with right middle lobe lesions mimicking pericardial effusion on ultrasonography are presented. They were admitted with fever and chest radiographs showed atelectasis or consolidation of the middle lobe of the right lung along the right heart border. A low-echogenic layer suggesting pericardial fluid was seen on ultrasonography, but with a spatial distribution closely corresponding to the lesions seen on the chest radiographs. If the possibility that a lung lesion adjacent to the heart can simulate pericardial fluid on ultrasonography is kept in mind, the correct diagnosis should not be difficult to make. (orig.)

  16. Liver-spleen scintiscan in kala-azar: case report

    Massive splenomegaly was found in a liver-spleen scan in a young man from Greece. Kala-azar was suggested as a possible cause and was confirmed by culturing Leishmania donovani from the bone marrow aspirate. The differential diagnosis of massive splenomegaly should include kala-azar when a patient has been in an endemic area

  17. The human spleen. Development and role in the immune system.

    Timens, Willem

    1988-01-01

    In the present thesis an extensive in situ characterization is given of cellular constituents of the human spleen, that play a role in the human immune system. The development of immunocompetent cells in their micro-environment was studied in early embryonic life, fetal life, infancy and childhood,

  18. Hepatitis B virus replication within the human spleen.

    Di Bisceglie, A M; Hoofnagle, J H

    1990-01-01

    Southern blot analysis of splenic DNA from three patients with chronic hepatitis B revealed the presence of replicative intermediate forms of viral DNA. Hepatitis B viral RNA was detected in splenic RNA from two cases. Thus, hepatitis B virus appears to replicate in the human spleen, although at a lower level than in the liver.

  19. Spontaneous rupture of the spleen after infectious mononucleosis

    Gulstad, Mikkel Bak; Thomsen, Henrik

    2013-01-01

    Non-traumatic rupture of the spleen (NRS) is a rare but serious complication to infectious mononucleosis (IM) and it is important to have in mind, when patients have IM. Although splenectomy has been advocated as the appropriate treatment for this problem, the trend goes towards conservative...

  20. A Possible Explanation to Paradox in Horse Spleen Ferritins

    寇谡鹏; 梁九卿

    2003-01-01

    There are contradicting opinions about the tunnelling experiments in horse-spleen ferritin particles. By distinguish the coherent and incoherent tunnelling processes, we give a unified explanation to different experiments. As a result, a possible explanation to the paradox is proposed

  1. Symptomatic and asymptomatic accessory navicular bones: Findings of Tc-99m MDP bone scintigraphy

    Chiu, N.-T.; Jou, I.-M.; Lee, B.-F.; Yao, W.-J.; Tu, D.-G.; Wu, P.-S

    2000-05-01

    AIM: The accuracy of bone scintigraphy in diagnosing symptomatic accessory navicular bones has not been well studied. We conducted a retrospective study to explore the results and use of scintigraphy in symptomatic and asymptomatic accessory navicular bones. MATERIALS AND METHODS: Thirteen patients with a total of 13 symptomatic and 10 asymptomatic accessory navicular bones were included in the study. We used a scoring system to grade the scintigraphic abnormalities. The patients' symptoms and scintigraphic findings were recorded. RESULTS: Though focally increased radiopharmaceutical uptake was observed in all symptomatic accessory naviculars, half of the asymptomatic accessory navicular bones had the same manifestations. The scoring system was of no value in differentiating symptomatic from asymptomatic accessory navicular bones. CONCLUSION: Bone scintigraphy is a sensitive but not a specific tool for diagnosing a symptomatic accessory navicular. Chiu, N.-T. (2000)

  2. Symptomatic and asymptomatic accessory navicular bones: Findings of Tc-99m MDP bone scintigraphy

    AIM: The accuracy of bone scintigraphy in diagnosing symptomatic accessory navicular bones has not been well studied. We conducted a retrospective study to explore the results and use of scintigraphy in symptomatic and asymptomatic accessory navicular bones. MATERIALS AND METHODS: Thirteen patients with a total of 13 symptomatic and 10 asymptomatic accessory navicular bones were included in the study. We used a scoring system to grade the scintigraphic abnormalities. The patients' symptoms and scintigraphic findings were recorded. RESULTS: Though focally increased radiopharmaceutical uptake was observed in all symptomatic accessory naviculars, half of the asymptomatic accessory navicular bones had the same manifestations. The scoring system was of no value in differentiating symptomatic from asymptomatic accessory navicular bones. CONCLUSION: Bone scintigraphy is a sensitive but not a specific tool for diagnosing a symptomatic accessory navicular. Chiu, N.-T. (2000)

  3. Aspiration biopsy of mammary analogue secretory carcinoma of accessory parotid gland: another diagnostic dilemma in matrix-containing tumors of the salivary glands.

    Levine, Pascale; Fried, Karen; Krevitt, Lane D; Wang, Beverly; Wenig, Bruce M

    2014-01-01

    Mammary analogue secretory carcinoma (MASC) is a newly described rare salivary gland tumor, which shares morphologic features with acinic cell carcinoma, low-grade cystadenocarcinoma, and secretory carcinoma of the breast. This is the first reported case of MASC of an accessory parotid gland detected by aspiration biopsy with radiologic and histologic correlation in a 34-year-old patient. Sonographically-guided aspiration biopsy showed cytologic features mimicking those of low-grade mucoepidermoid carcinoma, including sheets of bland epithelial cells, dissociated histiocytoid cells with intracytoplasmic mucinous material, and spindle cells lying in a web-like matrix. Histologic sections showed a circumscribed tumor with microcystic spaces lined by bland uniform epithelial cells and containing secretory material. The tumor cells expressed mammaglobin and BRST-2. The cytologic features, differential diagnosis, and pitfalls are discussed. The pathologic stage was pT1N0. The patient showed no evidence of disease at 1 year follow-up. PMID:22807408

  4. Mimicked Web Page Detection over Internet

    Y. Narasimha Rao

    2014-01-01

    Full Text Available Phishing is process of steeling valuable information such as ATM pins, Credit card details over internet. Where the attacker creates mimicked web pages from the legitimate web pages to fool users. In this paper, we propose an effective anti-phishing solution, by combining image based visual similarity based approach to detect plagiarized web pages. We used effective algorithms for our detection mechanism, speeded up Robust Features (SURF algorithm in order to generate signature based on extracting stable key points from the screen shot of the web page. When a legitimate web page is registered with our system, this algorithm applied on that web page in order to generate signatures, and these signatures are stored in the database for our trained system. When there is a suspected web page, this algorithm is applied to generate both the signatures of the suspected page and is verified against our database of corresponding legitimate web pages. Our results verified that our proposed system is very effective to detect the mimicked web pages with minimal false positives

  5. Inflammatory Myofibroblastic Tumor Mimicking Apical Periodontitis.

    Adachi, Makoto; Kiho, Kazuki; Sekine, Genta; Ohta, Takahisa; Matsubara, Makoto; Yoshida, Takakazu; Katsumata, Akitoshi; Tanuma, Jun-ichi; Sumitomo, Shinichiro

    2015-12-01

    Inflammatory myofibroblastic tumors (IMTs) are rare. IMTs of the head and neck occur in all age groups, from neonates to old age, with the highest incidence occurring in childhood and early adulthood. An IMT has been defined as a histologically distinctive lesion of uncertain behavior. This article describes an unusual case of IMT mimicking apical periodontitis in the mandible of a 42-year-old man. At first presentation, the patient showed spontaneous pain and percussion pain at teeth #28 to 30, which continued after initial endodontic treatment. Panoramic radiography revealed a radiolucent lesion at the site. Cone-beam computed tomographic imaging showed osteolytic lesions, suggesting an aggressive neoplasm requiring incisional biopsy. Histopathological examination indicated an IMT. The lesion was removed en bloc under general anesthesia, and the patient manifested no clinical evidence of recurrence for 24 months. Lesions of nonendodontic origin should be included in the differential diagnosis of apical periodontitis. Every available diagnostic tool should be used to confirm the diagnosis. Cone-beam computed tomographic imaging is very helpful for differential diagnosis in IMTs mimicking apical periodontitis. PMID:26602450

  6. Adenoid Cystic Carcinoma of Accessory Parotid Gland: A Case Report.

    Das, Somdipto; Nayak, Umanath K; Buggavetti, Rahul; Sekhar, Shobana

    2016-05-01

    The accessory parotid gland is salivary gland tissue separated from the main gland at a variable distance. This gland is histologically similar to the main gland, but has a higher incidence of malignant neoplasms than the main gland. Regarding the various malignant neoplasms, studies have shown higher incidences of mucoepidermoid carcinoma, with less than 2% being adenoid cystic carcinoma. We present a case of swelling in the midcheek region that, after clinical examination, was diagnosed as a case of neoplasm of the accessory parotid gland. On the basis of auxiliary investigations including intraoperative frozen section, it was concluded that it was adenoid cystic carcinoma, grade I, and after wide surgical resection, the tumor was removed without undergoing superficial parotidectomy. The patient received postoperative radiotherapy (RT) and was followed for 14 months without any recurrence or substantial facial asymmetry. PMID:26851989

  7. Accessory Nerve Schwannoma Containing Multiple Calcifed Foci: Unusual Presentation

    Leila Aghaghazvini

    2009-01-01

    Full Text Available "nIntroduction: Schwannomas are benign neural tumors which arise from the nerve sheath. Schwannomas of the accessory nerve are rare lesions. The clinical presentation of cranial nerve XI schwannomas relates to their location and extent: intracranial, jugular foramen, upper neck, or cervical spine. The extra cranial form is the least common reported. Calcified accessory schwannoma is rare. These lesions most often occur in the third to sixth decades of life. These tumors are slightly more common in women. "nCase presentation: We present a 37-year-old woman with a painless right posterior neck space mass which gradually appeared during one year. Except for mild numbness of the overlying skin of the mentioned mass, there were no other associated symptoms. Examination confirmed a 25 × 18mm, firm, mobile, non tender lump in the right posterior neck. Ultrasonography revealed a 30×20 mm hypo-echoic mass with multiple calcified foci and in color Doppler mild vascularity was detected. On contrast-enhanced CT scan of the neck a 30×18mm heterogeneous enhancing mass with multiple calcified foci (on non contrast cuts was found posterior to the neck vessels and had displaced them anteriorly. No surrounding fat stranding or any other gross pathology was evident in the other neck spaces. "nAccording to the above findings, lymphadenopathy due to TB or less possibly, fungal infection, hemangioma, lymphangiomam, schwannoma were our differential diagnosis. Mass resection and histopathology revealed schwannoma of the accessory nerve with an unusual calcification presentation. No evidence of recurrence was detected after one year. "nDiscussion: The clinical presentation of cranial nerve XI Schwannomas relates to their location and extent. The interesting point of this case was the unusual manifestation of accessory nerve schwannoma, not only because of its rarity but also because of its unusual calcification presentation and symptom-free appearance.  

  8. Importing home decorating accessories from India to Finland

    Ruuska, Jenni

    2011-01-01

    The commissioner of this thesis is a start-up company interested in importing home decorating accessories from India to Finland. There are two main goals of this thesis: firstly, to discover how importing from India would happen in practice, and secondly, to investigate what are the fairs the commissioner should visit in India. Thus, the theoretical framework includes following areas: logistics, consisting of money transfer and transportation; customs duties, discussing for instance the tarif...

  9. ALTERED HISTOLOGY OF THE THYMUS AND SPLEEN IN CONTAMINANT-EXPOSED JUVENILE AMERICAN ALLIGATORS

    Morphological difference in spleen and thymus are closely related to functional immune differences. Hormonal regulation of the immune system has been demonstrated in reptilian splenic and thymic tissue. Spleens and thymus were obtained from juvenile alligators at two reference si...

  10. Primary Angiosarcoma of the Spleen: An Oncological Enigma

    Myoteri Despoina

    2014-01-01

    Full Text Available Introduction. Primary splenic angiosarcoma is an extremely unusual neoplasm originating from sinusoidal vascular endothelium. Surgical extirpation is the mainstay of treatment of this highly malignant disease. Case Presentation. An 82-year-old woman was admitted with left pleural effusion and a palpable left upper quadrant abdominal mass, secondary to splenomegaly by two large splenic tumors. Classic open splenectomy was performed and angiosarcoma of the spleen was the final histopathological diagnosis, which was primary since no other disease site was revealed. Discussion. The incidence of the disease is 0.14–0.23 cases per million, with slight male predominance. Etiology is not established and clinical presentation may confuse even experienced physicians. Imaging modalities cannot differentiate the lesion from other vascular splenic neoplasms and the correct diagnosis is mainly set after histopathological examination of the resected spleen. As with other sarcomas, surgery is the only curative approach, while chemo- and radiotherapy have poor results. Prognosis remains dismal.

  11. Inflammatory pseudo tumor of the spleen. Radiologic findings

    The inflammatory splenic pseudo tumor is an uncommon benign lesion of unknown etiology that usually is detected incidentally in patients being examined for other disorders. We present the ultrasound, computed tomography (CT) and magnetic resonance (MR) findings in two patients (a 56-year-old woman and 67-year-old man) with inflammatory pseudo tumor of the spleen. Ultrasound images of the inflammatory splenic pseudo tumor show a hypoechoic mass with or without calcifications. In CT, the mass presents a low attenuation that is slightly enhanced by intravenous injection of an iodinated contrast medium. MR images show an isointense spleen in T1-weighted spin-echo sequences that is hypointense in T2-weighted sequences. The differential diagnosis should consider other more common splenic masses. but the definitive diagnosis can not be based on imaging methods alone. In the both cases, the final diagnosis was reached after splenectomy and pathological study. (Author) 8 refs

  12. ULTRASTRUCTURAL STUDY OF THE HEMOPOIETIC MICROENVIRONMENT IN HUMAN FETAL SPLEEN

    刘爱莲; 朱萍; 李学均; 张丽; 迟凤琴; 吴振铎; 宋雁南; 张亚坤

    1994-01-01

    Reciprocal interations between hemopoietic stromal cells and immature hemopoietic cells in human spleens obtained from 20 fetuses of 10-28 weeks gestation were observed by transmission electron microscopy and scanning electron microscopy.The close association of stromal cells with immature hemopoietic cells was confirmed under the electron microscope and a preasumptive HIM(Hemopoietic inductive mocroenvironment) was visualized.In regions of immature hemopoietice cell-reticular cell,endothelial cell,macrophage and interdigitating cell contact,some communicating structures were found between the plasma membranes of adjacent cells.moreovcer,the cytoplasm of these four stromal cells were full of various kinds of organelles.These results suggest that reticular cells,endothelial cells,macrophages and interdigitating cells are component parts of the HIM of human fetal spleen and that these cells have a nurturing function in relation to hemopoietic cells.

  13. A map of sphingosine 1-phosphate distribution in the spleen

    Ramos-Perez, Willy D.; Fang, Victoria; Escalante-Alcalde, Diana; Cammer, Michael; Schwab, Susan R.

    2015-01-01

    Despite the importance of signaling lipids, many questions remain about their function because we have few tools to chart lipid gradients in vivo. Here we describe a sphingosine 1-phosphate (S1P) reporter mouse, and use this mouse to define S1P distribution in the spleen. Surprisingly, the presence of blood does not predict the concentration of signaling-available S1P. Large areas of the red pulp are S1P-low, while S1P can be sensed by cells inside the white pulp near the marginal sinus. Lipid phosphate phosphatase 3 maintains low S1P concentrations in the spleen, and enables efficient marginal zone B cell shuttling. The exquisitely tight regulation of S1P availability may explain how a single lipid can simultaneously orchestrate many immune cell movements. PMID:26502404

  14. Effect of Breath Holding on Spleen Volume Measured by Magnetic Resonance Imaging

    Inoue, Yusuke; Nakajima, Ai; Mizukami, Shinya; Hata, Hirofumi

    2013-01-01

    Objective Ultrasonographic studies have demonstrated transient reduction in spleen volume in relation to apnea diving. We measured spleen volume under various respiratory conditions by MR imaging to accurately determine the influence of ordinary breath holding on spleen volumetry. Materials and Methods Twelve healthy adult volunteers were examined. Contiguous MR images of the spleen were acquired during free breathing and during respiratory manipulations, including breath holding at the end o...

  15. SPECT studies of liver and spleen - technique and normal anatomy

    A SPECT methodology for liver/spleen imaging is discussed with emphasis on quality control, conduct of study-imaging conduct of study-reconstruction. Normal transaxial anatomy and common artefacts which can masquerade as intrinsic disease are described. Structured artefacts which can be mistaken for real anatomy may occur from three general sources: camera field non-uniformities; statistical noise; attenuation. Each of these has a characteristic appearance which should alert the viewer to their possible presence

  16. Primary hemangiosarcoma of the spleen with angioscintigraphic demonstration of metastases

    Hermann, G G; Fogh, J; Graem, N;

    1984-01-01

    A case of primary hemangiosarcoma of the spleen in a 48-year-old woman is presented. Twenty-eight months after splenectomy the patient developed a severe anemia of the microangiopathic type, thrombocytopenia, and a leukoerythroblastic peripheral blood picture. In contrast to x-ray and conventiona...... extremely vascular metastases. Autopsy 15 months later confirmed the scintigraphic findings. Angiography with 99mTc-labeled erythrocytes seems to be useful for monitoring metastases from hemangiosarcomas....

  17. Pancreatitis-associated fluid collections involving the spleen

    The clinical and radiographic features of 2 patients with dissecting pancreatitis-associated fluid collections involving the spleen are described. A typical appearance of left upper quadrant fluid collection lateral to the splenic pulp was observed by ultrasonography (US) or computed body tomography (CBT). Although these findings are nonspecific, a left upper quadrant fluid collection may be characterized definitively by US/CBT-guided needle aspiration. (orig.)

  18. Mimicking Seawater For Culturing Marine Bacteria

    Rygaard, Anita Mac; Sonnenschein, Eva; Gram, Lone;

    2015-01-01

    Only about 1% of marine bacteria have been brought into culture using traditional techniques. The purpose of this study was to investigate if mimicking the natural bacterial environment can increase culturability.We used marine substrates containing defined algal polymers or gellan gum as...... solidifying agents, and enumerated bacteria from seawater and algal exudates. We tested if culturability could be influenced by addition of quorum sensing signals (AHLs). All plates were incubated at 15°C. Bacterial counts (CFU/g) from algal exudates from brown algae were highest on media containing algal...... polymers. In general, bacteria isolated from algal exudates preferred more rich media than bacteria isolated from seawater. Overall, culturability ranged from 0.01 to 0.8% as compared to total cell count. Substitution of agar with gellan gum increased the culturability of seawater bacteria approximately...

  19. Pelvic-peritoneal tuberculosis mimicking ovarian cancer

    Pelvic-peritoneal tuberculosis is a common extrapulmonary site in young females mimicking an advanced ovarian malignancy. We present 2 cases with the classical triad of advanced-stage ovarian carcinoma-ascites, abdominopelvic masses and elevated serum CA-125 levels. Laparoscopic examination revealed peritoneal nodules which on biopsy showed granulomatous inflammation and no malignant cells. Patients were started on anti-tuberculous therapy and on follow-up their symptoms as well as CA-125 levels normalized. Medical awareness of peritoneal tuberculosis is lacking and many young women with this disease undergo unnecessary extended surgery. Diagnostic laparoscopy combined with peritoneal biopsy seems to be a sufficient and safe method to provide a definitive diagnosis for this curable infection. If left untreated, the disease may disseminate and result in significant organ dysfunctions particularly infertility. (author)

  20. High-altitude cerebral oedema mimicking stroke.

    Yanamandra, Uday; Gupta, Amul; Patyal, Sagarika; Varma, Prem Prakash

    2014-01-01

    High-altitude cerebral oedema (HACO) is the most fatal high-altitude illness seen by rural physicians practising in high-altitude areas. HACO presents clinically with cerebellar ataxia, features of raised intracranial pressure (ICP) and coma. Early identification is important as delay in diagnosis can be fatal. We present two cases of HACO presenting with focal deficits mimicking stroke. The first patient presented with left-sided hemiplegia associated with the rapid deterioration in the sensorium. Neuroimaging revealed features suggestive of vasogenic oedema. The second patient presented with monoplegia of the lower limb. Neuroimaging revealed perfusion deficit in anterior cerebral artery territory. Both patients were managed with dexamethasone and they improved dramatically. Clinical picture and neuroimaging closely resembled acute ischaemic stroke in both cases. Thrombolysis in these patients would have been disastrous. Recent travel to high altitude, young age, absence of atherosclerotic risk factors and features of raised ICP concomitantly directed the diagnosis to HACO. PMID:24671373

  1. Contiguous spinal metastasis mimicking infectious spondylodiscitis

    Lee, Chul Min; Lee, Seung Hun [Dept. of Radiology, Hanyang University Hospital, Seoul (Korea, Republic of); Bae, Ji Yoon [Dept. of Pathology, National Police Hospital, Seoul (Korea, Republic of)

    2015-12-15

    Differential diagnosis between spinal metastasis and infectious spondylodiscitis is one of the occasional challenges in daily clinical practice. We encountered an unusual case of spinal metastasis in a 75-year-old female breast cancer patient that mimicked infectious spondylodiscitis. Magnetic resonance imaging (MRI) showed diffuse bone marrow infiltrations with paraspinal soft tissue infiltrative changes in 5 contiguous cervical vertebrae without significant compression fracture or cortical destruction. These MRI findings made it difficult to differentiate between spinal metastasis and infectious spondylodiscitis. Infectious spondylodiscitis such as tuberculous spondylodiscitis was regarded as the more appropriate diagnosis due to the continuous involvement of > 5 cervical vertebrae. The patient's clinical presentation also supported the presumptive diagnosis of infectious spondylodiscitis rather than spinal metastasis. Intravenous antibiotics were administered, but clinical symptoms worsened despite treatment. After pathologic confirmation by computed tomography-guided biopsy, we were able to confirm a final diagnosis of spinal metastasis.

  2. EVENTRATION OF LEFT HEMIDIAPHRAGM MIMICKING AS CAVITY

    Kansal

    2015-10-01

    Full Text Available Eventration of diaphragm is a condition in which there is abnormal elevation of the diaphragm as a result of thinning of muscular layer. It can be congenital as well as acquired. It is more common left sided. Herniation of the abdominal contents can be there. Clinical manifestations range from asymptomatic to life threatening respiratory distress requiring mechanical ventilator support. Ultrasound provides valuable information regarding the integrity of the diaphragm. Other imaging modalities include fluoroscopy, CT and MRI that provide valuable information when diagnosis is in doubt. We are presenting a case report of 25-year-old male with eventration of left hemidiaphragm mimicking as cavity. After taking detail history, examination and proper investigations we finally reached to this diagnosis.

  3. Membranoproliferative Glomerulonephritis and Inflammatory Pseudotumour of the Spleen

    U. Hadimeri

    2013-02-01

    Full Text Available Inflammatory pseudotumour is a rare condition that can affect various organs. The clinical and histologic appearance of the pseudotumour may mimic haematological, lymphoproliferative, paraneoplastic or malignant processes. A previously healthy 39-year-old man presented with nephrotic syndrome. He had a history of headaches, nausea and swollen ankles. Computed tomography of the abdomen revealed a 6-cm mass in the spleen. Following a renal biopsy, a diagnosis of membranoproliferative glomerulonephritis (MPGN type I was made. Splenectomy was performed and the examination revealed a mixed population of lymphocytes with predominantly T-cells, B-cells and lymphoplasmacytoid cells. Immunostaining confirmed that the small cells were mostly T-cells positive for all T-cell markers including CD2, CD3, CD4, CD5, CD7 and CD8. A diagnosis of inflammatory pseudotumour was established. The removal of the spleen was followed by remission of glomerulonephritis, but it was complicated by a subphrenic abscess and pneumonia. This association between an inflammatory pseudotumour of the spleen and MPGN has not been previously described. Abnormal immune response due to the inflammation leading to secondary glomerulonephritis might be the main pathogenic mechanism.

  4. Spontaneous rupture of the spleen secondary to amyloidosis

    Spontaneous splenic rupture (SSR) is a rare condition. It may be an idiopathic event or may occur secondary to a pathological condition of the spleen. Systemic amyloidosis is characterized by the extracellular deposition of amyloid proteins in one or more organs. The spleen can be affected in 41% of patients. Amyloidosis and consequently, splenic rupture may occur as a complication of amyloid infiltration. We present the case of a 61-year-old male with abdominal pain and hypotension. There were peritoneal signs during physical examination and falling hematocrit was reported in the laboratory tests. The patient was suspected of having an aortic dissection. Thoraco-abdominal computed tomography (CT) angiogram was negative and ultrasonography revealed splenic rupture and free fluid in the abdominal cavity. The patient underwent laparotomy when found hemoperitoneum as a consequence of splenic rupture. The subsequent histopathological report of the spleen revealed amyloidosis. Thus, in patients with abdominal pain and hypotension, we should suspect the possibility of a spontaneous splenic rupture, even without trauma or infection history. (author)

  5. Inflammatory pseudotumor of the spleen: A case report

    Selda SEÇKİN

    2008-05-01

    Full Text Available Inflammatory pseudotumors, also known as inflammatory miyofibroblastic tumors, are rare benign tumors of the spleen. The diagnosis of these tumors may be difficult, because they simulate some hematopoetic malignancies, leiomyosarcomas, inflammatory malignant fibrous histiocytoma and inflammatory fibrosclerosing lesions. They frequently occur at lung. But they are reported at gastrointestinal system, orbit, liver, bladder, lymph nodes, heart, brain, mesentery, omentum and spleen. Histologically they are composed of an admixture of cells like lymphocytes, plasma cells, foamy histiocytes, neutrophils and eosinophils with fibrosis, sclerosis and plump fibroblasts. Immunohistochemical stains show diffuse staining of tumor cells with vimentin and less common with myogenic markers like smooth muscle actin, muscle specific actin and desmin. CD 68 and focal cytokeratin immunoreactivity are found. We present a case of 53 year old female. Laboratory investigations were normal. Abdominal ultrasonography showed a heterogenous, hypoechoic nodular mass measuring 30x27 mm in the superior portion of the spleen parenchyma. Splenectomy was performed. Histologically the lesion was composed of inflammatory cells and miyofibroblasts. The case was diagnosed as inflammatory pseudotumor (Inflammatory miyofibroblastic tumor with histological and immunohistochemical findings.

  6. The spleen and skin wound healing in Xenopus adults.

    Franchini, Antonella; Della Rocca, Annalaura; Bertolotti, Evelina

    2016-07-01

    In most vertebrates, the regenerative capacity to restore lost/damage tissues to original structure and functionality decreases at some time during ontogenesis. To evaluate the role of the acquired immunity in the decline of regenerative potential, we examined the cellular responses elicited in the spleen during skin repair in Xenopus adults. Modifications in the architecture were found to be induced and were remarkable 14 days postinjury when the spleen increased significantly in size. In white pulp, the periarteriolar lymphoid sheaths were associated with follicles having central light zones, morphologically similar to germinal centers. With the progress of healing, pigment-containing cells were seen to accumulate in both white and red pulp regions. Moreover, compared to controls, the cells immunoreactive to anti-cytokines (TNF-α, TGF-β1) and -iNOS increased from the first days after wounding. The 14th day, the positive cells formed a dense network of reticular cells in central regions of lymphoid follicles and more frequent reactive leukocytes were detected within the red pulp. A higher number of lymphoid cells immunostained with anti-CD3ε were also observed in the perifollicular zone. The results suggest that the spleen of adult frogs is involved in skin wound healing with the expansion of lymphoid compartments. J. Morphol. 277:888-895, 2016. © 2016 Wiley Periodicals, Inc. PMID:27059432

  7. Abscesses of the spleen: Report of three cases

    Constantin Fotiadis; Giagkos Lavranos; Pavlos Patapis; Gabriel Karatzas

    2008-01-01

    Abscess of the spleen is a rare discovery, with about 600 cases in the international literature so far. Although it may have various causes, it is most usually associated with trauma and infections of the spleen. The latter are more common in the presence of a different primary site of infection, especially endocarditis or in cases of ischemic infarcts that are secondarily infected.Moreover, immunosuppression is a major risk factor.Clinical examination usually reveals a combination of fever, left-upper-quadrant abdominal pain and vomiting.Laboratory findings are not constant. Imaging is a necessary tool for establishing the diagnosis, with a choice between ultrasound and computed tomography.Treatment includes conservative measures, and surgical intervention. In children and in cases of solitary abscesses with a thick wall, percutaneous catheter drainage may be attempted. Otherwise, splenectomy is the preferred approach in most centers. Here, we present three cases of splenic abscess. In all three,splenectomy was performed, followed by rapid clinical improvement. These cases emphasize that current understanding of spleen abscess etiology is still limited,and a study for additional risk factors may be necessary.

  8. Splenosis after splenectomy and spleen tissue autoimplantation: Late followup study

    Carlos T Brandt

    2012-01-01

    Full Text Available Aim : In children suffering from severe hepatosplenic schistosomiasis, the surgical protocol includes splenectomy and autoimplantation of spleen morsels in the major omentum, which has the potential of reducing the overwhelming postsplenectomy infection (OPSI. The purpose of the study was to evaluate the remaining splenosis, with the mean postoperative followup of 12.1 ± 5.6 years; to compare the efficacy of the 2 evaluation tools. Materials and Methods : Nineteen patients underwent, when they were children, portal decompression and autoimplantation of spleen. After a mean age of 23.4 ± 5.3 years, they were investigated regarding the number of infections and OPSI. They had undergone hepatosplenic scintigraphy with labeled colloidal SnTc 99m and abdominal ultrasound. It was considered efficient splenosis when the patients presented with 5 or more spleen nodules. The evaluation was performed by 3 observers. Results : None of the patients had increased infection rate or developed OPSI. Sixteen (84.2% presented efficient splenosis. Conclusions : The remaining postoperative splenosis was considered efficient in the majority of patients in the long-term followup; and nuclear medicine was considered the gold standard for splenosis evaluation.

  9. File list: ALL.Oth.50.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available ALL.Oth.50.AllAg.Spleen hg19 All antigens Others Spleen SRX347277,SRX263894,SRX1369...3904,SRX134738,SRX188949 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Oth.50.AllAg.Spleen.bed ...

  10. File list: ALL.Oth.20.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available ALL.Oth.20.AllAg.Spleen hg19 All antigens Others Spleen SRX347277,SRX263894,SRX1369...8960,SRX263904,SRX188949 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Oth.20.AllAg.Spleen.bed ...

  11. File list: ALL.Oth.05.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available ALL.Oth.05.AllAg.Spleen hg19 All antigens Others Spleen SRX134736,SRX347277,SRX2638...7283,SRX134738,SRX188949 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Oth.05.AllAg.Spleen.bed ...

  12. File list: ALL.Oth.10.AllAg.Spleen [Chip-atlas[Archive

    Full Text Available ALL.Oth.10.AllAg.Spleen hg19 All antigens Others Spleen SRX134736,SRX347277,SRX2638...4738,SRX263904,SRX188949 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Oth.10.AllAg.Spleen.bed ...

  13. Langerhans cell histiocytosis forming an asymptomatic solitary nodule in the spleen.

    Lam, K Y; Chan, A C; Wat, M. S.

    1996-01-01

    A case of solitary Langerhans cell histiocytosis (LCH) in the spleen of a 29 year old Chinese man, discovered incidentally at necropsy, is reported. This is the first documented case of LCH confined to the spleen and suggests that LCH should be included in the differential diagnosis of space occupying lesions in the spleen.

  14. MR Imaging Findings of Painful Type II Accessory Navicular Bone: Correlation with Surgical and Pathologic Studies

    Choi, Yun Sun; Lee, Kyung Tai; Kang, Heung Sik; Kim, Eun Kyung

    2004-01-01

    Objective To evaluate the MR imaging findings of painful type II accessory navicular bone and to correlate these with the surgical and pathologic findings. Materials and Methods The MR images of 17 patients with medial foot pain and surgically proven type II accessory navicular abnormalities were reviewed. The changes of signal intensity in the accessory navicular, synchondrosis and adjacent soft tissue, the presence of synchondrosis widening, and posterior tibial tendon (PTT) pathology on th...

  15. Reliable Sex and Strain Discrimination in the Mouse Vomeronasal Organ and Accessory Olfactory Bulb

    Tolokh, Illya I.; Fu, Xiaoyan; Holy, Timothy E.

    2013-01-01

    Animals modulate their courtship and territorial behaviors in response to olfactory cues produced by other animals. In rodents, detecting these cues is the primary role of the accessory olfactory system (AOS). We sought to systematically investigate the natural stimulus coding logic and robustness in neurons of the first two stages of accessory olfactory processing, the vomeronasal organ (VNO) and accessory olfactory bulb (AOB). We show that firing rate responses of just a few well-chosen mou...

  16. BILATERAL ACCESSORY BREAST TISSUE PRESENTING AS MASS IN AXILLA WITH LEAKING MILK

    Vineet

    2014-11-01

    Full Text Available Accessory breasts are an uncommon entity. They may present as asymptomatic masses or cause symptoms such as pain or restriction of arm movements even some time milk leaks from accessory breast. It may prove to be diagnostic challenge if found in locations along or outside the mammary line. We report a very rare case of an ectopic bilateral accessory breast presenting as mass in axilla with leaking milk in lactating young female. FNAC was diagnostic tool

  17. An exploration study to find important factors influencing on brand in car accessory market

    Naser Azad; Seyed Mohsen Seyed Aliakbar; Majid Tavassoli; Mohammad Reza Jafar Zadeh

    2013-01-01

    Supplying car accessory is one of the most important growing industries in the world. Every year, millions of cars are produced and people need to have the access to necessary car accessory. In this paper, we present an exploration study to detect important factors influencing car accessory market. The proposed study designs a questionnaire in Likert scale consists of 16 questions, distributes it among 200 experts and analyses it using factor analysis. Cronbach alpha and Kaiser-Meyer-Olkin Me...

  18. Frequency of Syncope in Patients with Accessory Atrioventricular Connection

    A Aslani

    2010-03-01

    Full Text Available Background: Syncope in patients with Wolff-Parkinson-White (WPW syndrome is related to rapid reciprocating tachycardia or rapid ventricular response over the accessory pathway during atrial fibrillation (AF. The aim of this retrospective study is to evaluate the frequency of syncope in patients with WPW syndrome. Methods: We reviewed the records of 150 consecutive patients with WPW syndrome.Results: There were 20 patients (13.3% who reported at least one episode of syncope and 130 patients (86.7% without such a history.Conclusion: Syncope is relatively frequent in patients with WPW. Patient with WPW syndrome who has experienced this symptom should be thoroughly evaluated.

  19. Accessory breast tissue in axilla masquerading as breast cancer recurrence

    Goyal Shikha

    2008-01-01

    Full Text Available Ectopic or accessory breast tissue is most commonly located in the axilla, though it may be present anywhere along the milk line. Development is hormone dependent, similar to normal breast tissue. These lesions do not warrant any intervention unless they produce discomfort, thus their identification and distinction from other breast pathologies, both benign and malignant, is essential. We report a case with locally advanced breast cancer who presented with an ipsilateral axillary mass following surgery, radiotherapy, and chemotherapy. Subsequent evaluation with excision biopsy showed duct ectasia in axillary breast tissue and the patient was continued on hormone therapy with tamoxifen.

  20. Accessory auricles with ectopic digit a new association

    Mittal R

    2002-01-01

    Full Text Available A 25- year -old male had accessory auricles at birth and developed ectopic digit since 1 year. As this association could not be traced in literature, it is being reported. Ectopic digit in the present case was differentiated from supernumerary digit because of late onset at the age of 24 years, ruccurence after surgery, unilateral appearance, had origin from central depression of a well defined, round plaque on the distal inter-phalangeal joint of left thumb and had curvature simulating cutaneous horn. X-ray thumb did not reveal any bone formation in this ectopic digit.

  1. GSM accessories now available from the CERN Stores

    Labo Telecom

    2001-01-01

    As of 1st October you can order and receive GSM accessories from the CERN stores like any other article. The CERN stores also manage GSM telephones but, for technical reasons, only the Labo Telecom shop (Building 31, Room S026) is able to make the standard sales, repairs and exchanges for authorised persons with a CERN subscription. Labo Telecom will thus become a specialist shop, open from 11 a.m. to 12 a.m., and will apply the usual rules and authorisation procedures of the stores. The paper form for requests for GSM subscriptions is being computerized and will be available on EDH in the near future.

  2. Liver and spleen volume variations in patients with hepatic fibrosis

    Peng Liu; Peng Li; Wen He; Li-in Zhao

    2009-01-01

    AIM: To study the liver and spleen volume variations in hepatic fibrosis patients at different histopathological stages.METHODS: Multidetector computed tomography (MDCT) scan was performed in 85 hepatic fibrosis patients. Liver volume (LV) and spleen volume (SV) were measured. Fifteen healthy individuals served as a control group (S0). The patients were divided into stage 1 (S1) group ( n = 34), stage 2 (S2) group ( n = 25), stage 3 (S3) group ( n = 16), and stage 4 (S4)group ( n = 10) according to their histopathological stage of liver fibrosis.RESULTS: The LV and standard LV(SLV)had a tendency to increase with the severity of fibrosis, but no statistical difference was observed in the 5 groups (LV: F = 0.245, P = 0.912; SLV: F = 1.902,P = 0.116). The SV was gradually increased with the severity of fibrosis, and a statistically significant difference in SV was observed among the 5 groups( P < 0.01). The LV/SV ratio and SLV/SV ratio were gradually decreased with the aggravation of hepatic fibrosis, and statistically significant differences in both LV/SV and SLV/SV were found among the 5 groups ( P< 0.01).CONCLUSION: The absence of obvious LV reduction in patients with chronic liver disease may be a morphological index of patients without liver cirrhosis. The SV is related to the severity of fibrosis, and the spleen of patients with advanced fibrosis is enlarged evidently. The LV/SV ratio and SLV/SV ratio are of a significant clinical value in the diagnosis of advanced liver fibrosis.

  3. Management of Blunt Trauma to the Spleen (Part 1

    Seyed Abbas Banani

    2010-06-01

    Full Text Available AbstractSpleen is the most frequent solid organ to be injured in bluntabdominal trauma. Considering its important role in providingimmunity and preventing infection by a variety of mechanisms,every attempt should be made, if possible, to salvagethe traumatized spleen at any age particularly in children. Afterprimary resuscitation, mandatory requirements for nonoperativemanagement include absence of homodynamic instability,lack of associated major organ injury, admission inthe intensive care unit for high-grade splenic injury and in theward for milder types with close monitoring. About two thirdof the patients would respond to non-operative management.In most patients, failure of non-operative measures usuallyoccur within 12 hours of management. Determinant role ofabdominal sonography or computed tomography, and in selectedcases, diagnostic peritoneal lavage, for appropriate decisioncannot be overemphasized. However, the high status ofclinical judgment would not be replaced by any paraclinicalinvestigations. When operation is unavoidable, if possible,spleen saving procedures (splenorrhaphy or partial splenectomyshould be tried. In case of total splenectomy, autotransplantation,preferably in the omental pouch, may lead toreturn of immunity, at least partially, to prevent or reduce thechance of subsequent infection. Although total splenectomywith autograft is immunologically superior to total splenectomy-only procedure, these patients should also be protectedby vaccination and daily antibiotic for certain period of time.The essential steps for prevention of overwhelming infectionafter total splenectomy are not only immunization and administrationof daily antibiotic (up to 5 years of age or one year inolder children, but include education and information aboutthis dangerous complication. When non-operative managementis successful, the duration of activity restriction (inweeks is almost equal to the grade of splenic injury plus 2.Iran J Med Sci 2010

  4. Mucormycosis resulting in a pseudoaneurysm in the spleen

    Nevitt, P.C.; Das Narla, L. [Medical College of Virginia, Virginia Commonwealth Univ., Richmond (United States); Hingsbergen, E.A. [Children' s Radiologic Institute, Children' s Hospital, Columbus, OH (United States)

    2001-02-01

    Mucormycosis is an uncommon and frequently fatal fungal infection. It characteristically affects patients with diabetes mellitus or patients with severe immunosuppression. The hallmark of mucormycosis infection is tissue infarction and vascular invasion. We present clinical data and imaging studies of a 16 year-old child with acute lymphoblastic leukemia complicated by disseminated mucormycosis resulting in a pseudoaneurysm of the spleen. This was successfully managed by a combination of systemic antifungal therapy (Amphotericin B) and surgery (splenectomy). This entity has not been described in the literature. (orig.)

  5. The accessory coracobrachialis muscle: ultrasound and MR features

    Bauones, Salem [Centre hospitalier de l' Universite de Montreal (CHUM), Department of Radiology, Hopital Saint-Luc, Montreal, Quebec (Canada); Moraux, Antoine [Imagerie Medicale Jacquemars Gielee, Lille (France)

    2015-09-15

    To present the prevalence, clinical relevance, and ultrasound (US) and magnetic resonance imaging (MRI) appearances of the accessory coracobrachialis (ACB) muscle. We present an US prospective study of the ACB muscle over a 2-year period. Five of the eight patients with suspected ACB on US were subsequently examined by MRI. An ACB muscle was demonstrated by US in eight patients (eight shoulders), including seven females, one male, with mean age 39 years, over 770 (664 patients) consecutive shoulder US examinations referred to our institution yielding a prevalence of 1.04 %. In dynamic US assessment, one case of subcoracoid impingement secondary to a bulky ACB was diagnosed. No thoracic outlet syndrome was encountered in the remaining cases. MRI confirmed the presence of the accessory muscle in five cases. ACB muscle is a rarely reported yet not uncommon anatomic variation of the shoulder musculature encountered only in eight of 664 patients referred for shoulder US study. Its US and MRI appearance is described. One of our patients presented with subcoracoid impingement related to the presence of an ACB. (orig.)

  6. Digital dermatitis of the accessory digits of dairy cows

    Celso A. Rodrigues

    2010-03-01

    Full Text Available This report characterizes the digital dermatitis (DD lesions in the accessory digits of dairy cows and presents data on the applied therapy. Fifteen Holstein cattle with DD affecting the accessory digits of the hindlimbs from four dairy farms with previous history of DD were evaluated. Lesions were excised, the wounds were sutured, and a topical application of oxytetracycline powder covered by bandaging was associated with a single parenteral administration of long acting oxytetracycline IM (20mg/kg. Tissue samples were obtained for histopathology and transmission electronic microscopy (TEM. Lesions from all the animals were recuperated 15 days after surgical procedure. Overal, most DD lesions were papillomatous epidermal projections or wartlike verrucous lesions. Histopathologically, samples revealed hyperplasia of epidermis with hyperkeratosis, several mitoses in the stratum basale and elongated rete ridges in the superficial and middle dermis. TEM revealed long, thin spirochete-like bacteria. Morphologic features of lesions and its response to therapy were comparable to those described for DD.

  7. The accessory coracobrachialis muscle: ultrasound and MR features

    To present the prevalence, clinical relevance, and ultrasound (US) and magnetic resonance imaging (MRI) appearances of the accessory coracobrachialis (ACB) muscle. We present an US prospective study of the ACB muscle over a 2-year period. Five of the eight patients with suspected ACB on US were subsequently examined by MRI. An ACB muscle was demonstrated by US in eight patients (eight shoulders), including seven females, one male, with mean age 39 years, over 770 (664 patients) consecutive shoulder US examinations referred to our institution yielding a prevalence of 1.04 %. In dynamic US assessment, one case of subcoracoid impingement secondary to a bulky ACB was diagnosed. No thoracic outlet syndrome was encountered in the remaining cases. MRI confirmed the presence of the accessory muscle in five cases. ACB muscle is a rarely reported yet not uncommon anatomic variation of the shoulder musculature encountered only in eight of 664 patients referred for shoulder US study. Its US and MRI appearance is described. One of our patients presented with subcoracoid impingement related to the presence of an ACB. (orig.)

  8. Nipple adenoma arising from axillary accessory breast: a case report

    Shioi Yoshihiro

    2012-11-01

    Full Text Available Abstract Nipple adenoma is a relatively rare benign breast neoplasm, and cases of the disease arising from the axillary accessory breast have very seldom been reported in the English literature. We report a case of nipple adenoma arising from axillary accessory breast including clinical and pathological findings. An 82-year-old woman presented with the complaint of a small painful mass in the right axilla. Physical examination confirmed a well-defined eczematous crusted mass that was 8 mm in size. The diagnosis of nipple adenoma was made from an excisional specimen on the basis of characteristic histological findings. Microscopic structural features included a compact proliferation of small tubules lined by epithelial and myoepithelial cells, and the merging of glandular epithelial cells of the adenoma into squamous epithelial cells in the superficial epidermal layer. Because clinically nipple adenoma may resemble Paget’s disease and pathologically can be misinterpreted as tubular carcinoma, the correct identification of nipple adenoma is an important factor in the differential diagnosis for axillary tumor neoplasms. Virtual slides The virtual slide(s for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1186821489769063

  9. Behaviour of bentonite accessory minerals during the thermal stage

    Arcos, David; Bruno, Jordi [Enviros-QuantiSci, Barcelona (Spain); Benbow, Steven; Takase, Hiro [Quintessa Limited, Henley-on-Thames (United Kingdom)

    2000-03-15

    This report discusses in a quantitative manner the evolution of the accessory minerals in the bentonite as a result of the thermal event exerted by the spent fuel in the near field. Three different modelling approaches have been used and the results compared between them. The three different approaches have been calculated using two Differential Algebraic Equation (DAE) solver: DYLAN (Model-1) and the Nag DAE solver, d02ngf (Model-2) and the third approach (Model-3) using the last version of PHREEQC. The results from these calculations indicate the feasibility of the modelling approach to model the migration of bentonite accessory minerals and relevant aqueous species throughout the thermal gradient. These calculations indicate that the migration of quartz and quartz polymorphs is a lesser problem. The aqueous speciation of Ca in the bentonite pore water is fundamental in order to define the potential migration of anhydrite during the thermal stage. If CaSO{sub 4}(aq) is the predominant aqueous species, then anhydrite dissolves at the initial groundwater migration times through bentonite. However, if Ca{sup 2+} is considered to be the dominant Ca species at the bentonite pore water, then anhydrite migrates towards the clay/granite interface. This is the main difference in the chemical systems considered in the three model approaches used in this work. The main process affecting the trace mineral behaviour in bentonite is cation exchange. This process controls the concentration of calcium, which results in a direct control of the calcite precipitation-dissolution.

  10. Forest haulage accessories for agricultural tractors in 1995

    This bulletin is a review of hydraulic timber cranes, forest trailers and skidding grapples and winches available on the Finnish markets in autumn 1995 as accessories for mounting onto agricultural tractors. The information is mainly based on the responses of the manufacturers and distributors to a mail questionnaire. Ten producers make timber cranes and a total of 46 crane models are presented. Nearly all the cranes can be mounted onto either the 3-point hitching device, the connecting rail of a trailer/sled, or directly onto the tractor frame. The net lifting force of the cranes varies in between 19.9 - 40.0 kNm. The maximum reach of the cranes varies between 4.3 and 9.8 m. The mechanical twin-lever system has almost entirely replaced the conventional six-lever operating type. Electro-hydraulic pre-control is included in the accessories available for many of the cranes. There are twelve producers and 37 models of forestry trailers, with eight including power transmission. All these trailers are of the bogie type. Their carrying capacity varies between 6 000 - 12 500 kilos. Five manufacturers produce six models of 3-point hitchable hydraulic skidding grabbles were listed. all are provided with a frame joint easing the job of grasping and skidding of timber. Skidding winches mountable onto the 3-point hitching device are of three producers and seven models. The tractive force varies between 28 and 60 kN. All are provided with a disc clutch

  11. Controlled Deposition of HAp Mimicking Tooth Enamel

    2005-01-01

    Chemical compositions and microsturcture of mature human tooth enamel were investigated by XRD , FTIR and SEM to further understand the characteristics of tooth enamel. In order to obtain apatite crystals chemically and structurally similar to those in tooth enamel, biomimetic way was employed. Selfassembled monolyers terminated with-SO3 H groups were used as deposition substrates and 1.5 SBF ( the concentrations of Ca2+ and PO43- ions 1.5 times than those in simulated body fluid ) with and without 5 ppm F- were used as soaking medium. The XRD and FTIR results showed that both the deposited fluoride-substituted hydroxyapatite( F-HAp ) crystals in 1.5 SBF with F- and hydroxyapatite ( HAp ) crystals in 1.5 SBF were carbonate-containing, mimicking human tooth enamel in chemical compositions. The SEM photos showed that needle-like F-HAp crystals bad large aspect ratios and grew in bundles, which were similar to the crystals in human tooth enamel.The results provide available information on dental restoration.

  12. Hyperdense dots mimicking microcalcifications : Mammographic findings

    To differentiate fine hyperdense dots mimicking microcalcifications from true microcalcifications on mammography. Mammograms showing hyperdense dots in ten patients (mean age, 59 years) were evaluated. Two radiologists were asked to differentiate with the naked eye the hyperdense dots seen on ten mammograms and proven microcalcifications seen on ten mammograms. Densitometry was also performed for all lesions and the contrast index was calculated. The shape and distribution of the hyperdense dots were evaluated and enquires were made regarding any history of breast disease and corresponding treatment. Biopsies were performed for two patients with hyperdense dots. Two radiologists made correct diagnoses in 19/20 cases(95%). The contrast index was 0.10-0.88 (mean 0.58) for hyperdense dots and 0.02-0.45 (mean 0.17) for true microcalcifications. The hyperdense dots were finer and homogeneously rounder than the microcalcifications. Distribution of the hyperdense dots was more superficial in subcutaneous fat (seven cases) and subareolar area (six cases). All ten patients with hyperdense dots had history of mastitis and abscesses and had been treated by open drainage (six cases) and/or folk remedy (four cases). In eight patients, herb patches had been attached. Biopsies of hyperdense dots did not show any microcalcification or evidence of malignancy. These hyperdense dots were seen mainly in older patients. Their characteristic density, shape, distribution and clinical history makes differential diagnosis from true microcalcifications easy and could reduce unnecessary diagnostic procedures such as surgical biopsy

  13. Hyperdense dots mimicking microcalcifications : Mammographic findings

    Kim, Nam Hyeon; Park, Jeong Mi; Goo, Hyun Woo; Bang, Sun Woo [Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)

    1996-12-01

    To differentiate fine hyperdense dots mimicking microcalcifications from true microcalcifications on mammography. Mammograms showing hyperdense dots in ten patients (mean age, 59 years) were evaluated. Two radiologists were asked to differentiate with the naked eye the hyperdense dots seen on ten mammograms and proven microcalcifications seen on ten mammograms. Densitometry was also performed for all lesions and the contrast index was calculated. The shape and distribution of the hyperdense dots were evaluated and enquires were made regarding any history of breast disease and corresponding treatment. Biopsies were performed for two patients with hyperdense dots. Two radiologists made correct diagnoses in 19/20 cases(95%). The contrast index was 0.10-0.88 (mean 0.58) for hyperdense dots and 0.02-0.45 (mean 0.17) for true microcalcifications. The hyperdense dots were finer and homogeneously rounder than the microcalcifications. Distribution of the hyperdense dots was more superficial in subcutaneous fat (seven cases) and subareolar area (six cases). All ten patients with hyperdense dots had history of mastitis and abscesses and had been treated by open drainage (six cases) and/or folk remedy (four cases). In eight patients, herb patches had been attached. Biopsies of hyperdense dots did not show any microcalcification or evidence of malignancy. These hyperdense dots were seen mainly in older patients. Their characteristic density, shape, distribution and clinical history makes differential diagnosis from true microcalcifications easy and could reduce unnecessary diagnostic procedures such as surgical biopsy.

  14. Non-harmful insertion of data mimicking computer network attacks

    Neil, Joshua Charles; Kent, Alexander; Hash, Jr, Curtis Lee

    2016-06-21

    Non-harmful data mimicking computer network attacks may be inserted in a computer network. Anomalous real network connections may be generated between a plurality of computing systems in the network. Data mimicking an attack may also be generated. The generated data may be transmitted between the plurality of computing systems using the real network connections and measured to determine whether an attack is detected.

  15. Mimicking Stem Cell Niches to Increase Stem Cell Expansion

    Dellatore, Shara M.; Garcia, A. Sofia; Miller, William M.

    2008-01-01

    Niches regulate lineage-specific stem cell self-renewal vs. differentiation in vivo and are comprised of supportive cells and extracellular matrix components arranged in a 3-dimensional topography of controlled stiffness in the presence of oxygen and growth factor gradients. Mimicking stem cell niches in a defined manner will facilitate production of the large numbers of stem cells needed to realize the promise of regenerative medicine and gene therapy. Progress has been made in mimicking com...

  16. Gallbladder metastasis from renal cell carcinoma mimicking acute cholecystitis

    Sand M

    2009-02-01

    Full Text Available Abstract Renal cell carcinoma constitutes about 3% of adult malignancies. It has a high metastatic potential associated with synchronous or metachronous metastatic disease. Further, it is known to metastasize mainly to the lung, bone, brain, liver, or adrenal glands. In very rare cases it can metastasize to the gallbladder mimicking acute cholecystitis on clinical exam. In this case we present a patient who developed a gallbladder metastasis five years after a renal cell carcinoma mimicking acute cholecystitis.

  17. 21 CFR 878.4200 - Introduction/drainage catheter and accessories.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Introduction/drainage catheter and accessories. 878.4200 Section 878.4200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Introduction/drainage catheter and accessories. (a) Identification. An introduction/drainage catheter is...

  18. 77 FR 27663 - Airworthiness Directives; Aeronautical Accessories, Inc. High Landing Gear Forward Crosstube...

    2012-05-11

    ... Accessories, Inc. High Landing Gear Forward Crosstube Assembly AGENCY: Federal Aviation Administration (FAA... directive (AD) for Aeronautical Accessories, Inc. (AAI) high landing gear forward crosstube assemblies... crosstubes. The proposed actions are intended to prevent failure of a crosstube, collapse of the landing...

  19. 77 FR 67261 - Airworthiness Directives; Aeronautical Accessories, Inc., High Landing Gear Forward Crosstube...

    2012-11-09

    ... Accessories, Inc., High Landing Gear Forward Crosstube Assembly AGENCY: Federal Aviation Administration (FAA... Accessories, Inc. (AAI) high landing gear forward crosstube assemblies (crosstubes) installed on Agusta S.p.A..., collapse of the landing gear, and subsequent loss of control of the helicopter. DATES: This AD is...

  20. 77 FR 5420 - Airworthiness Directives; Aeronautical Accessories Inc. High Landing Gear Aft Crosstube Assembly

    2012-02-03

    ... Accessories Inc. High Landing Gear Aft Crosstube Assembly AGENCY: Federal Aviation Administration (FAA), DOT... (AD) for the Aeronautical Accessories Inc. (AAI) High Landing Gear Aft Crosstube Assembly (aft... proposed actions are intended to prevent failure of a crosstube, collapse of the landing gear,...

  1. 77 FR 37768 - Airworthiness Directives; Aeronautical Accessories, Inc., High Landing Gear Aft Crosstube Assembly

    2012-06-25

    ... Accessories, Inc., High Landing Gear Aft Crosstube Assembly AGENCY: Federal Aviation Administration (FAA), DOT... Accessories, Inc. (AAI), High Landing Gear Aft Crosstube Assembly (aft crosstube) installed on certain Bell... failure of a crosstube, collapse of the landing gear, and subsequent loss of control of the...

  2. Intermittent torsion of accessory hepatic lobe: An unusual cause of recurrent right upper quadrant pain

    An accessory lobe of the liver is a rare congenital anomaly that can undergo torsion and present as an acute surgical emergency. It is rarely diagnosed preoperatively. We report the preoperative utility of CT scan and MRI in the diagnosis and surgical planning of a case of intermittent accessory hepatic lobe torsion

  3. Ex Vivo Preparations of the Intact Vomeronasal Organ and Accessory Olfactory Bulb

    Doyle, Wayne I.; Hammen, Gary F.; Meeks, Julian P.

    2014-01-01

    The mouse accessory olfactory system (AOS) is a specialized sensory pathway for detecting nonvolatile social odors, pheromones, and kairomones. The first neural circuit in the AOS pathway, called the accessory olfactory bulb (AOB), plays an important role in establishing sex-typical behaviors such as territorial aggression and mating. This small (

  4. ACCESSORY FUNCTIONING BREAST TISSUE AS A LARGE MASS IN THE AXILLA

    Tripathi

    2013-01-01

    Full Text Available ABSTRACT: Accessory breasts are an uncommon entity & more un common when it is functioning. They may present as asymptomatic mass al ong the mammary ridge or symptoms evident during menarche, menstruation, pregnancy & l actation. We report a case of unilateral accessory breast in right axilla which was secretin g milk on day 3rd postpartum

  5. The posterior triangle and the painful shoulder: spinal accessory nerve injury.

    Williams, W W; Twyman, R. S.; Donell, S. T.; Birch, R

    1996-01-01

    Forty-three cases of accessory nerve injury referred to the Peripheral Nerve Injury Unit have been reviewed. Accessory nerve injury results in a characteristic group of symptoms and signs. Referral for treatment is usually delayed, the average time being 11.3 months. Surgical treatment resulted in improvement of symptoms in almost all cases.

  6. Chloroquine inhibits accessory cell presentation of soluble natural and synthetic protein antigens

    Buus, S; Werdelin, O

    1984-01-01

    We have studied the in vitro effect of the lysosomotrophic agent, chloroquine, on the presentation of soluble protein antigens by guinea pig accessory cells. Chloroquine inhibited the capacity of antigen-pulsed accessory cells to stimulate proliferation in appropriately primed T cells. The effect...

  7. 21 CFR 878.4400 - Electrosurgical cutting and coagulation device and accessories.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Electrosurgical cutting and coagulation device and....4400 Electrosurgical cutting and coagulation device and accessories. (a) Identification. An electrosurgical cutting and coagulation device and accessories is a device intended to remove tissue and...

  8. Intermittent torsion of accessory hepatic lobe: An unusual cause of recurrent right upper quadrant pain

    Jambhekar Kedar

    2010-01-01

    Full Text Available An accessory lobe of the liver is a rare congenital anomaly that can undergo torsion and present as an acute surgical emergency. It is rarely diagnosed preoperatively. We report the preoperative utility of CT scan and MRI in the diagnosis and surgical planning of a case of intermittent accessory hepatic lobe torsion.

  9. 76 FR 24522 - In the Matter of Certain Handbags, Luggage, Accessories, and Packaging Thereof; Notice of...

    2011-05-02

    ...,519,828. 76 FR 585-6 (Jan. 5, 2011). The complainant named as respondents T&T Handbag Industrial Co... COMMISSION In the Matter of Certain Handbags, Luggage, Accessories, and Packaging Thereof; Notice of... handbags, luggage, accessories, and packaging thereof by reason of infringement of certain claims of...

  10. [Pathogenesis and morphology of hemophagocytic syndrome in the spleen].

    Gattenlöhner, S; Müller-Hermelink, H K

    2008-03-01

    Hemophagocytic syndrome (macrophage activation syndrome) is a group of disorders characterized by clinical, histological and biological symptoms of T-lymphocytes/NK cell-driven macrophage stimulation with subsequent hemophagocytosis which can be observed in various organs, particularly in the bone marrow and spleen. The main clinical symptoms include cytopenia, multiple organ dysfunction, fever unresponsive to antibiotics, hepatosplenomegaly and rash. Besides rare inherited immune system anomalies (primary hemophagocytic syndrome), the most prevalent etiologies of hemophagocytic syndrome are infections (viral, bacterial and parasitic), cancers, lymphoproliferative disorders and systemic diseases. Hemophagocytic syndrome is treated with immunosuppressives, cytostatic drugs, plasmapheresis and intravenous immunoglobulins/anti-TNF antibodies and due to the multiorgan involvement and the associated high mortality, recognition of early serum changes, such as very high levels of ferritin is mandatory. The most relevant histological changes are the increase of histiocytes showing evidence of phagocytosis of erythroid cells, platelets and granulocytes as well as in the spleen a rarefaction of the white pulpa with lack of lymph follicles and abundant lymphocytes, plasma cells and plasma cell precursors in the pulpa cords. PMID:18210111

  11. Asymptomatic lymphangioma involving the spleen and retroperitoneum in adults

    Sook Hee Chung; Young Sook Park; Yun Ju Jo; Seong Hwan Kim; Dae Won Jun; Byoung Kwan Son; Jun Young Jung; Dae Hyun Baek; Dong Hee Kim; Yoon Young Jung; Won Mi Lee

    2009-01-01

    Lymphangioma, a benign neoplasm of the lymphatic system, is common in children but rare in adults. Its clinical manifestations include abdominal pain, nausea,vomiting and a palpable mass. However, abdominal sonography or abdominal computed tomography (CT) scan can also incidentally reveal lymphangioma. A larger or symptomatic lymphangioma is treated with total resection to prevent recurrence, infection, torsionand enlargement. Although lymphangioma rarely becomes malignant, its prognosis is generally good.We report a cystic lymphangioma of the spleen and retroperitoneum, which was incidentally found in a 56-year-old man who was hospitalized due to a colon mass. Physical examination showed no specific findings.Abdominal CT revealed a 5.7 cm, non-enhanced multilobulated cystic mass with multiple septa in the spleen and a 10 cm lobulated cystic mass in the paraaorticarea. Splenectomy and retroperitoneal resectionof the cystic mass were conducted. The endothelium of splenic and retroperitoneal cyst was immunohistochemically stained with D2-40 antibody. The patient was finally diagnosed with splenic cystic and retroperitoneal cavernous lymphangioma.

  12. Genomic DNA characterization of pork spleen by Raman spectroscopy

    Guzmán-Embús, D. A.; Orrego Cardozo, M.; Vargas-Hernández, C.

    2013-11-01

    In this paper, the study of Raman signal enhancement due to interaction between ZnO rods and pork spleen DNA is reported. ZnO microstructures were synthesized by the Sol-Gel method and afterward combined with porcine spleen DNA extracted in the previous stages, following standardized cell lysis, deproteinization, and precipitation processes. Raman spectroscopy was used for the characterization of structures of ZnO and ZnO-DNA complex, and the results show the respective bands of ZnO wurtzite hexagonal phase for modes E2 (M), A1(TO), E2(High), E1(LO), and 2LO. Due to the SERS effect in the spectral range from 200 to 1800 cm,-1 Raman bands caused by vibrations of the deoxyribose C-O-C binding were also observed, producing deformation of the ring as shown in the 559 cm-1 peak. The broad band at 782 cm-1, together with the complex vibration of the string 5'-COPO-C3', is over a wide band of thymine (790 cm-1) or cytosine (780 cm-1). A prominent band near 1098 cm-1 assigned to symmetric stretching vibration phosphodioxy group (PO2-) DNA backbone is most favoured in intensity by the addition of ZnO particles originated by the SERS effect. This effect suggests a possible mechanism for enhancing the Raman signal due to the electromagnetic interaction between a DNA molecule and the flat surface of the ZnO rod.

  13. Measurement of spleen by computed tomography in normal Korean adults

    Computed tomography potentially offers the most accurate noninvasive method of estimating volume of a solid organ in vivo. The study was undertaken to obtain standard values of size, volume and mass of normal spleen in Korean adults. The authors analysed 109 cases of abdominal computed tomography of normal Korean adults. The results were as follows; 1. The average splenic volume in adults was 173.17 ± 59.02 cm3 in male, 160.43 ± 61.72 cm3 in female and total average, 160.98 ± 60.41 cm3. 2. The average splenic mass in adults were 181.20 ± 61.16 gm in male, 166.44 ± 64.68 gm in female and total average, 174 ± 63.0 gm. 3. The average size of the spleen in adult males was 9.39 ± 1.33 cm in breath, 3.8 ± 0.69 cm in thickness, and 7.97 ± 1.43 cm in height; in adult females, 9.25 ± 1.46 cm,3.51 ± 0.65 cm, 8.05 ± 1.35 cm,respectively; total average, 9.32 ± 1.39 cm, 3.70 ± 0.60 cm, 8.01 ± 1.39 cm, respectively. 4. There was no statistical difference of volume, mass and size between sex and age

  14. The spleen in the sickling disorders: an update

    Khatib, Rana; Sarnaik, Sharada A. [Wayne State University School of Medicine, Children' s Hospital of Michigan, Carmen and Ann Adams Department of Pediatrics, Detroit, MI (United States); Rabah, Raja [Wayne State University School of Medicine, Department of Pathology, Detroit, MI (United States)

    2009-01-15

    In early life, patients with sickle cell disease (SCD) can have acute, life-threatening emergencies related to splenic hypofunction (overwhelming bacterial sepsis), as well as anemic crises from acute splenic sequestration because of sudden pooling of blood in the spleen. The landmark penicillin prophylaxis study in 1985 showed a remarkable decrease in mortality from sepsis in young children with SCD who were treated with oral penicillin prophylaxis compared to placebo. Since that study, newborns are screened for SCD and placed on oral penicillin prophylaxis in nearly all of the United States, as well as in other countries where the disease is highly prevalent. The previously described permanent, complete and nearly universal ''autosplenectomy'' emerging by late childhood or early adulthood is now challenged by recent findings of reversibility of splenic dysfunction by the antisickling drug hydroxyurea or by successful allogeneic stem cell transplantation, even in older patients. Imaging techniques for hypofunction of the spleen are the most commonly used modalities to guide the clinician in decisions regarding medical or surgical management. (orig.)

  15. Data from quantitative label free proteomics analysis of rat spleen.

    Dudekula, Khadar; Le Bihan, Thierry

    2016-09-01

    The dataset presented in this work has been obtained using a label-free quantitative proteomic analysis of rat spleen. A robust method for extraction of proteins from rat spleen tissue and LC-MS-MS analysis was developed using a urea and SDS-based buffer. Different fractionation methods were compared. A total of 3484 different proteins were identified from the pool of all experiments run in this study (a total of 2460 proteins with at least two peptides). A total of 1822 proteins were identified from nine non-fractionated pulse gels, 2288 proteins and 2864 proteins were identified by SDS-PAGE fractionation into three and five fractions respectively. The proteomics data are deposited in ProteomeXchange Consortium via PRIDE PXD003520, Progenesis and Maxquant output are presented in the supported information. The generated list of proteins under different regimes of fractionation allow assessing the nature of the identified proteins; variability in the quantitative analysis associated with the different sampling strategy and allow defining a proper number of replicates for future quantitative analysis. PMID:27358910

  16. Histomorphological changes in thymus and spleen after cyclooxygenase inhibitors treatment

    Poeta O.N.

    2009-01-01

    Full Text Available The influence of cyclooxygenase inhibitors on the lymphoid organs histomorphology has been examined in the matured outbread white mice. Diclofenac, meloxicam, celecoxib, but not rofecoxib has shown depressive action on the im-munocompetetive organs histomorphologic structure. Macroscopic study has revealed a decrease in the weight of the spleen and thymus. Light microscopy has shown a decrease in the number of thymocytes, due to degradation of cortex area. In the lobular medulla it has been observed microcirculation changes in the view of venules and capillaries distention, arteriolar wall thickening. In the spleen it has been shown a decrease in the white pulp volume, disappearing of the reactive centers in follicles. Also subcapsular edema and relative stroma volume increase has been seen frequently. The use of highly selective COG-2 inhibitor rofecoxib has not revealed statistically truthful changes in microscopic examination in comparison to the control group. That could vote for the absence of depressive action on the immune organ histomorphologic structure.

  17. Asymptomatic lymphangioma involving the spleen and retroperitoneum in adults

    Sook Hee Chung, Young Sook Park, Yun Ju Jo, Seong Hwan Kim, Dae Won Jun, Byoung Kwan Son, Jun Young Jung, Dae Hyun Baek, Dong Hee Kim, Yoon Young Jung, Won Mi Lee

    2009-11-01

    Full Text Available Lymphangioma, a benign neoplasm of the lymphatic system, is common in children but rare in adults. Its clinical manifestations include abdominal pain, nausea, vomiting and a palpable mass. However, abdominal sonography or abdominal computed tomography (CT scan can also incidentally reveal lymphangioma. A larger or symptomatic lymphangioma is treated with total resection to prevent recurrence, infection, torsion and enlargement. Although lymphangioma rarely becomes malignant, its prognosis is generally good. We report a cystic lymphangioma of the spleen and retroperitoneum, which was incidentally found in a 56-year-old man who was hospitalized due to a colon mass. Physical examination showed no specific findings. Abdominal CT revealed a 5.7 cm, non-enhanced multilobulated cystic mass with multiple septa in the spleen and a 10 cm lobulated cystic mass in the paraaortic area. Splenectomy and retroperitoneal resection of the cystic mass were conducted. The endothelium of splenic and retroperitoneal cyst was immunohistochemically stained with D2-40 antibody. The patient was finally diagnosed with splenic cystic and retroperitoneal cavernous lymphangioma.

  18. Fast Image Retrieval of Textile Industrial Accessory Based on Multi-Feature Fusion

    沈文忠; 杨杰

    2004-01-01

    A hierarchical retrieval scheme of the accessory image database is proposed based on textile industrial accessory contour feature and region feature. At first smallest enclosed rectangle[1] feature (degree of accessory coordination) is used to filter the image database to decouple the image search scope. After the accessory contour information and region information are extracted, the fusion multi-feature of the centroid distance Fourier descriptor and distance distribution histogram is adopted to finish image retrieval accurately. All the features above are invariable under translation, scaling and rotation. Results from the test on the image database including 1,000 accessory images demonstrate that the method is effective and practical with high accuracy and fast speed.

  19. Progress in the clinical imaging research of bone diseases on ankle and foot sesamoid bones and accessory ossicles

    Li, Xiaozhong; Shi, Lenian; Liu, Taiyun; Wang, Lin

    2012-01-01

    Sesamoid bones and accessory ossicles are research focuses of foot and ankle surgery. Pains of the foot and ankle are related to sesamoid bones and accessory ossicles. The specific anatomical and functional relationship of sesamoid bones and accessory ossicles can cause such bone diseases as the dislocation of sesamoid bones and accessory bones, infection, inflammation and necrosis of sesamoid bones, cartilage softening, tenosynovitis of sesamoid bones and the sesamoid bone syndrome. However,...

  20. 30 CFR 75.1106-5 - Maintenance and tests of liquefied and nonliquefied compressed gas cylinders; accessories and...

    2010-07-01

    ... nonliquefied compressed gas cylinders; accessories and equipment; requirements. 75.1106-5 Section 75.1106-5... liquefied and nonliquefied compressed gas cylinders; accessories and equipment; requirements. (a) Hose lines, gages, and other cylinder accessories shall be maintained in a safe operating condition. (b)...

  1. Anatomical study of spinal accessory nerve using ultrasonography

    Canella, Clarissa [Service de Radiologie et d’Imagerie Musculosquelettique, Centre de Consultations et d’Imagerie de l’Appareil Locomoteur, CHRU, 59037, Lille (France); Serviço de Radiologia e Diagnostico por Imagem, Universitadade Federal do Rio de Janeiro, Rio de janeiro (Brazil); Demondion, Xavier [Service de Radiologie et d’Imagerie Musculosquelettique, Centre de Consultations et d’Imagerie de l’Appareil Locomoteur, CHRU, 59037, Lille (France); Laboratoire d’Anatomie, Faculté de Médecine de Lille, 59037, Lille (France); Abreu, Evandro [Service de Radiologie et d’Imagerie Musculosquelettique, Centre de Consultations et d’Imagerie de l’Appareil Locomoteur, CHRU, 59037, Lille (France); Marchiori, Edson [Serviço de Radiologia e Diagnostico por Imagem, Universitadade Federal do Rio de Janeiro, Rio de janeiro (Brazil); Cotten, Hervé [Anatomie et cytologie pathologiques, Bd de la Liberté, 59000, Lille (France); Cotten, Anne, E-mail: anne.cotten@chru-lille.fr [Service de Radiologie et d’Imagerie Musculosquelettique, Centre de Consultations et d’Imagerie de l’Appareil Locomoteur, CHRU, 59037, Lille (France)

    2013-01-15

    Objective: The purpose of our study was to demonstrate that ultrasonography may allow a precise assessment of the course and relationships of the spinal accessory nerve (SAN). Material and methods: This study, initially undertaken in 7 cadavers, was followed by high-resolution ultrasonographic study in 15 volunteers (30 nerves) by two radiologists in consensus. The location, course and relations to the adjacent anatomic structures of the SAN were analyzed. Results: The precise course of the SAN between the lateroposterior border of the sternocleidomastoid muscle and the anterior border of the trapezius muscle could be identified by high-resolution ultrasonography. In contrast, clinical bone landmarks were not found helpful for the identification of the nerve. Conclusion: The SAN can be clearly depicted by means of ultrasonography. Knowledge of the nerve's precise location, which may evidence individual variations, may have useful clinical applications.

  2. Anatomical study of spinal accessory nerve using ultrasonography

    Objective: The purpose of our study was to demonstrate that ultrasonography may allow a precise assessment of the course and relationships of the spinal accessory nerve (SAN). Material and methods: This study, initially undertaken in 7 cadavers, was followed by high-resolution ultrasonographic study in 15 volunteers (30 nerves) by two radiologists in consensus. The location, course and relations to the adjacent anatomic structures of the SAN were analyzed. Results: The precise course of the SAN between the lateroposterior border of the sternocleidomastoid muscle and the anterior border of the trapezius muscle could be identified by high-resolution ultrasonography. In contrast, clinical bone landmarks were not found helpful for the identification of the nerve. Conclusion: The SAN can be clearly depicted by means of ultrasonography. Knowledge of the nerve's precise location, which may evidence individual variations, may have useful clinical applications

  3. New Scopes, New Accessories, New Stents for Interventional Endoscopic Ultrasound.

    Chapman, Christopher G; Siddiqui, Uzma D

    2016-01-01

    Technological advances have rapidly expanded the therapeutic potential of endoscopic ultrasound (EUS). Innovations in stent technology; directed adjunctive therapy for pancreatic tumors, including radiofrequency ablation and fiducial marker placement; advanced imaging modalities, including needle-based confocal laser endomicroscopy; and new echoendoscopes, such as the forward-viewing linear echoendoscope, are emerging as safe and effective tools and devices for providing a broad range of treatments and therapies previously not thought possible. In this review, we summarize and discuss the new echoendoscopes, accessories, and stents for interventional EUS and highlight the recent literature on technical and therapeutic efficacy. The therapeutic role and indications for EUS are rapidly evolving well beyond its current limits as new EUS-specific designed tools are designed, and ultimately, should help achieve the goal of improving patient outcomes. PMID:26855923

  4. Accessory liver lobe of the gallbladder in adults.

    Handra-Luca, Adriana

    2016-09-01

    The accessory liver lobe (ALL) of the gallbladder wall is rare, mentioned by Meckel since 1822. We present two cases of ALL occurring in two adult women. The ALLs were diagnosed at microscopic examination of cholecystectomy specimens for lithiasic cholecystitis and were located at the gallbladder body level. They measured 0.5 and 1.1 cm and were pediculated from the gallbladder serosa. Luschka duct complexes were seen in the adjacent subserosa in one of the cases. The main clinical relevance of ALL of the gallbladder resides in the differential diagnosis with a lymph node and in the risk of peroperative hemorragia or bile leakage by sectioning of the connecting blood vessels and/or bile duct. Intraparietal ALL may interfere with dysmotility, possibly resulting in bile stagnation and stone formation. PMID:27147442

  5. Relationship etween Electroacupuncture and Spleen Function on Leukocyte

    孙平龙; 周玉宝; 毛慧娟; 吴会会; 卜凌林; 孙佳; 郭衡艳

    2007-01-01

    目的:观察电针治疗白细胞减少症的疗效、特点及其与脾脏超微结构改变的关系,探讨针灸调节白细胞的作用机制.方法:通过家兔静脉注射环磷酰胺复制白细胞减少症模型,采用电针治疗,分别每天于耳缘静脉采血进行外周血白细胞计数和分类,观察血象变化,并于处死前麻醉动物,开腹取脾组织电镜下观测脾血窦基膜小孔口径大小.结果:与模型对照组比较,电针治疗组动物外周血白细胞数量迅速上升,粒细胞发生核右移(P<0.01).电针治疗组脾血窦基膜小孔口径大于模型对照组(P<0.05).结论:电针可以使白细胞减少的机体白细胞数量迅速得到恢复,在治疗的早期主要与调节脾脏功能有关.%Objective: To explore the underlying mechanism by which acupuncture regulates the peripheral leukocyte count and observe the relationship between the effects of electroacupuncture (EA) and the spleen ultrastructure in leukopenia. Methods: Leukopenia models of rabbits were established by injecting cyclophosphamide (CY) into rabbits' ear vein,and then the rabbits were treated with acupuncture. The peripheral leukocyte count and classification were measured daily. At last, after the animals were anesthesized, the abdominal cavity was opened, and a piece of spleen tissue was cut. The diameter of splenic sinusoid basal lamina eyehole was measured under electric microscope. Results: The peripheral blood leukocyte count in the EA group increased significantly with shift to right of the granulocyte nuclei compared with model control group (P<0.01). Moreover, the calibers of splenic sinusoid basal lamina eyehole in the EA group were larger than those in the model control group (P<0.05). Conclusion: Acupuncture can enhance the peripheral leukocyte count by promoting spleen activity in the early phase of leukopenia.

  6. Alterations in spleen growth and sequestering function in animals receiving trypan blue.

    Dumont, A. E.; Schinella, R. A.; Fazzini, E. P.

    1981-01-01

    Trypan-blue-induced alterations in spleen size and sequestering activity were studied in rats as possible experimental counterparts of the splenic enlargement and dysfunction associated with lymphomas in man. The spleen was examined radiographically and histologically following the i.v. administration of tantalum particles in animals receiving 4-17 s.c. injections of trypan blue at fort-nightly intervals and in control animals. Spleen size and sequestering activity increased in all rats recei...

  7. Complicated malaria and a covert ruptured spleen: a case report.

    Waweru, Peter; Macleod, Jana; Gikonyo, Anthony

    2014-01-01

    Spontaneous splenic rupture in complicated malaria is an uncommon cause of hemoperitoneum in the tropics. The exact incidence of splenic rupture is unknown, largely due to under-reporting, but has been estimated at ∼2%. Its pathophysiology is linked to the formation of a subcapsular hematoma. Upon rupture, patients present with features of shock and peritonitis and in most cases (95%), computed tomography (CT) scan detects the splenic injury. Patients should be managed conservatively with splenectomy reserved for patients with shock and hemoperitoneum due to risk of post-splenectomy sepsis. We report the case of a 38-year-old man with severe malaria who presented with fever, chills and abdominal pains. A CT scan abdomen failed to reveal splenic parenchymal injury or any splenic extravasation of contrast. Conservative management was unsuccessful. Exploratory laparatomy confirmed the spleen as the site of bleeding necessitating a splenectomy. PMID:25395608

  8. Post-Traumatic Pseudocyst of the Spleen: Sclerotherapy with Ethanol

    We report a case of successful percutaneous treatment of a chronic post-traumatic splenic pseudocyst using alcohol as the sclerosing agent. A 26-year-old man presented with a symptomatic cystic mass located in the spleen. Aspiration of 300 ml of fluid was only temporarily effective, and therefore a drainage catheter was placed 3 days later. After histopathologic and microbiologic exclusion of a malignant or infectious origin, local sclerotherapy with alcohol was performed because of recurrence after percutaneous drainage. This therapy was repeated six times within 2 weeks. Two weeks later, the remaining volume was determined to be 16 ml. Six months after treatment the cyst was no longer visible. To our knowledge this is the first case of a chronic post-traumatic splenic cyst treated with alcohol. Percutaneous sclerotherapy of a symptomatic post-traumatic splenic pseudocyst may be an alternative to surgical treatment

  9. Undifferentiated spleen colonies: an attempt to induce differentiation into eosinophils

    Repeated injections of casein caused a 4-fold increase in the overall number of colonies in the spleens of sublethally irradiated, polycythemic mice. Chronic (12 injections) casein treatment considerably increased the number of eosinophil and of undifferentiated colonies, but not that of granuloid ones. A reduction in number and size of eosinophil colonies took place between the sixth and the ninth day after irradiation. No such reduction occurred with undifferentiated colonies. Stimulation with casein for only 3 (consecutive) days before irradiation caused a similar increase in eosinophil colonies, only a moderate increase in undifferentiated ones and a very marked increase in granuloid colonies. Evidence for a change of undifferentiated colonies into eosinophil ones under conditions of eosinopoiesis was looked for, but not detected. No correlation was found between the amyloid-inducing capacity of caseins and their eosinopoietic potency

  10. Deleterious effect of ultraviolet-B radiation on accessory function of human blood adherent mononuclear cells

    The effects of ultraviolet-B radiation (UV-B) on accessory function of human blood adherent mononuclear cells (ADH) for antigen and mitogen-induced responses, and production by ADH of the amplifying cytokine interleukin 1 (IL-1) were examined. Responder lymphocytes were rendered accessory cell dependent by treatment of nonadherent cells with OKIal + complement. UV-B depressed accessory function of ADH in a dose-dependent manner. UV-B decreased accessory function of ADH for tetanus toxoid-induced responses and phytohaemagglutinin-induced responses. UV-B also decreased accessory activity of peripheral blood mononuclear cells but not Epstein-Barr virus-transformed B cells for a PPD-reactive T cell line. Interleukin 1 (IL-1) activity of supernatants of ADH was assayed on C3H/HeJ mouse thymocytes. Pretreatment of ADH with UV-B decreased lipopolysaccharide-stimulated IL-1 activity. Lysates of UV-B irradiated, LPS-stimulated ADH had no discernible IL-1 activity. Addition of IL-1 partially restored accessory activity of UV-B irradiated ADH for lymphocyte responses to TT. Exposure of ADH to TT or PHA for 30 min before irradiation blocked the inhibitory effect of UV-B on accessory activity. Thus, low doses of UV-B are deleterious to accessory function and to production of IL-1 by ADH. Interference with production of cytokines and with initial interactions of accessory cells with antigen and mitogen may be critical to the effects of UV-B on immunoregulatory function of ADH. (author)

  11. Invasive ductal carcinoma arising from dense accessory breast visualized with 99mTc-MIBI breast-specific γ imaging.

    Yoon, Hai-Jeon; Sung, Sun Hee; Moon, Byung In; Kim, Bom Sahn

    2014-08-01

    Primary accessory breast cancer is extremely rare, and the diagnostic efficacy of Tc-MIBI breast-specific γ imaging (BSGI) has not been reported elsewhere. We present a case of primary carcinoma arising from dense accessory breast that was visualized with BSGI. A 43-year-old female patient with a palpable axillary mass underwent mammography, which showed dense parenchyma on both of the anatomic and accessory breasts with no abnormality. Subsequent BSGI showed no abnormal uptake in bilateral anatomic breasts, but focal abnormal uptake was noted in the accessory breast. Permanent pathologic evaluation confirmed invasive ductal carcinoma (not otherwise specified type) of the accessory breast. PMID:24445272

  12. Munchausen syndrome mimicking psychiatric disease with concomitant genuine physical illness

    Almeida, Jaime; da Silva, Joaquim Alves; Xavier, Miguel; Gusmão, Ricardo

    2010-01-01

    Munchausen syndrome is a disorder in which patients intentionally produce symptoms mimicking physical or psychiatric illnesses with the aim to assume the sick role and to gain medical attention. Once a patient receives a Munchausen syndrome diagnosis every complaint made thence tends to be regarded with scepticism by clinical staff. However, it is possible that a bona fide illness, which might be disregarded, may coexist in these patients. We report a case of MS mimicking psychiatric disease with concomitant genuine acute physical illness. Despite the initial doubts about the veracity of the latter, due to its prompt recognition, treatment was successful. PMID:22798096

  13. Multiple echogenic sports in spleen - Gandy-gamma nodules in congestive splenomegaly -

    We report a case showing multiple widespread echogenic foci in ultrasonogram and multiple high density spots in computed tomogram in spleen, which has congestive splenomegaly secondary due to liver cirrhosis and portal vein thrombosis. Pathologically the lesions in spleen correspond with mainly homosiderin deposits in Gandy-Gamna nodules seen in congestive splenomegaly.

  14. Multiple echogenic sports in spleen - Gandy-gamma nodules in congestive splenomegaly -

    Kim, Ki Whang; Jeong, Hyeon Joo; Chi, Hoon Sang [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    1988-10-15

    We report a case showing multiple widespread echogenic foci in ultrasonogram and multiple high density spots in computed tomogram in spleen, which has congestive splenomegaly secondary due to liver cirrhosis and portal vein thrombosis. Pathologically the lesions in spleen correspond with mainly homosiderin deposits in Gandy-Gamna nodules seen in congestive splenomegaly.

  15. A RARE CASE OF TORSION OF WANDERING SPLEEN IN A MULTIPAROUS WOMAN

    Venkateshwar Rao

    2015-02-01

    Full Text Available Wandering spleen is a rare clinical entity characterized by splenic hypermobility resulting from laxity or maldevelopment of supporting splenic ligaments 1 . Its major complication is splenic torsion , which is a potentially fatal surgical emergency 2 . We present a rare case of wandering spleen with torsion and splenic infarction in a multiparous patient.

  16. Spontaneous rupture of the spleen: A rare complication in a patient with lupus nephritis on hemodialysis

    Nadri Quaid

    2010-01-01

    Full Text Available Rupture of the spleen is a life threatening condition. We report a 40-year-old fe-male patient, a known case of lupus nephritis receiving hemodialysis, who developed spontaneous rupture of the spleen during the course of her illness. The patient was managed conservatively with gradual regression of hematoma without further complications.

  17. Observation on Therapeutic Effect of the Depression of Heart-spleen Deficiency with Wuling Capsule

    To evaluate the effect on the treatment of depression belong to the type of heart-spleen deficiency with Wuling capsule, 37 patients were assigned into two groups: the deficiency of both the heart and spleen group (I) and the non deficiency of both the heart and spleen group (II). The efficacy of two groups was surveyed and compared after taken Wuling capsule 2 and 4 weeks,respectively. After treatment, there was a difference (P0.05). The satisfactory effects were showed on various kinds of depressions using wuling capsules,while deficiency of both the heart and spleen group effects were better than that of the non deficiency of both the heart and spleen group. (authors)

  18. Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus)

    Laman, J.D.; Meurs, M. van; Schellekens, M.M.; Boer, M. de; Melchers, B.; Massacesi, L.; Lassmann, H.; Claassen, E.; Hart, B.A. 't

    1998-01-01

    Accessory molecules and cytokines are involved in the immunopathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) in rodent models, and are potential targets for immunotherapy. Evaluation of such experimental therapies requires appropriate animal models. Therefo

  19. One nose, one brain: contribution of the main and accessory olfactory system to chemosensation

    Carla eMucignat

    2012-11-01

    Full Text Available The accessory olfactory system is present in most tetrapods. It is involved in the perception of chemical stimuli, being implicated also in the detection of pheromone. However, it is sensitive also to some common odorant molecules, which have no clear implication in intraspecific chemical communication. The accessory olfactory system may complement the main olfactory system, and may contribute different perceptual features to the construction of a unitary representation, which merges the different chemosensory qualities. Crosstalk between the main and accessory olfactory systems occurs at different levels of central processing, in brain areas where the inputs from the two systems converge. Interestingly, centrifugal projections from more caudal brain areas are deeply involved in modulating both main and accessory sensory processing. A high degree of interaction between the two systems may be conceived, and partial overlapping appears to occur in many functions. Therefore, the central chemosensory projections merge inputs from different organs to obtain a complex chemosensory picture.

  20. Effect of Breath Holding on Spleen Volume Measured by Magnetic Resonance Imaging.

    Yusuke Inoue

    Full Text Available Ultrasonographic studies have demonstrated transient reduction in spleen volume in relation to apnea diving. We measured spleen volume under various respiratory conditions by MR imaging to accurately determine the influence of ordinary breath holding on spleen volumetry.Twelve healthy adult volunteers were examined. Contiguous MR images of the spleen were acquired during free breathing and during respiratory manipulations, including breath holding at the end of normal expiration, breath holding at deep inspiration, and the valsalva maneuver, and spleen volume was measured from each image set based on the sum-of-areas method. Acquisition during free breathing was performed with respiratory triggering. The duration of each respiratory manipulation was 30 s, and five sets of MR images were acquired serially during each manipulation.Baseline spleen volume before respiratory manipulation was 173.0 ± 79.7 mL, and the coefficient of variance for two baseline measures was 1.4% ± 1.6%, suggesting excellent repeatability. Spleen volume decreased significantly just after the commencement of respiratory manipulation, remained constant during the manipulation, and returned to the control value 2 min after the cessation of the manipulation, irrespective of manipulation type. The percentages of volume reduction were 10.2% ± 2.9%, 10.2% ± 3.5%, and 13.3% ± 5.7% during expiration breath holding, deep-inspiration breath holding, and the valsalva maneuver, respectively, and these values did not differ significantly.Spleen volume is reduced during short breath-hold apnea in healthy adults. Physiological responses of the spleen to respiratory manipulations should be considered in the measurement and interpretation of spleen volume.

  1. One nose, one brain: contribution of the main and accessory olfactory system to chemosensation

    Mucignat-Caretta, Carla; Redaelli, Marco; Caretta, Antonio

    2012-01-01

    The accessory olfactory system is present in most tetrapods. It is involved in the perception of chemical stimuli, being implicated also in the detection of pheromones. However, it is sensitive also to some common odorant molecules, which have no clear implication in intraspecific chemical communication. The accessory olfactory system may complement the main olfactory system and may contribute different perceptual features to the construction of a unitary representation, which merges the diff...

  2. Properties of Phase Transition of Traffic Flow on Urban Expressway Systems with Ramps and Accessory Roads

    梅超群; 刘业进

    2011-01-01

    In this paper, we develop a cellular automaton model to describe the phase transition of traffic flow on urban expressway systems with on-off-ramps and accessory roads. The lane changing rules are given in detailed, the numerical results show that the main road and the accessory road both produce phase transitions. These phase transitions will omen be influenced by the number of lanes, lane changing, the ramp flow, the input flow rate, and the geometry structure.

  3. Migration and Labour mobility in the Leather Accessories Manufacture in India

    Jesim Pais

    2006-01-01

    Liberalisation and the policies thereafter have lead to a definite increase in production and export from the leather accessories industry in India. The focus of this paper is on migration and labour mobility in the leather accessories manufacture in Dharavi, Mumbai. The core data for the paper are from field surveys conducted in the industry in Dharavi, Mumbai, in 2000–2001, roughly 10 years after the economic reforms of the 1990s were initiated.

  4. Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity

    Asai, M; Ramachandrappa, S.; Joachim, M.; Shen, Y.; Zhang, R.; Nuthalapati, N.; V. Ramanathan; Strochlic, D. E.; Ferket, P.; Linhart, K.; Ho, C.; Novoselova, T. V.; Garg, S.; Ridderstrale, M.; Marcus, C

    2013-01-01

    Melanocortin receptor accessory proteins (MRAPs) modulate signaling of melanocortin receptors in vitro. To investigate the physiological role of brain-expressed Melanocortin 2 Receptor Accessory Protein 2 (MRAP2), we characterized mice with whole body and brain-specific targeted deletion of Mrap2, both of which develop severe obesity at a young age. Mrap2 interacts directly with Melanocortin 4 Receptor (Mc4r), a protein previously implicated in mammalian obesity, and it enhances Mc4r-mediated...

  5. Activity Regulates Functional Connectivity from the Vomeronasal Organ to the Accessory Olfactory Bulb

    Hovis, Kenneth R.; Ramnath, Rohit; Dahlen, Jeffrey E.; Romanova, Anna L.; LaRocca, Greg; Bier, Mark E.; Urban, Nathaniel N.

    2012-01-01

    The mammalian accessory olfactory system is specialized for the detection of chemicals that identify kin and conspecifics. Vomeronasal sensory neurons (VSNs), residing in the vomeronasal organ, project axons to the accessory olfactory bulb (AOB) where they form synapses with principle neurons, known as mitral cells. The organization of this projection is quite precise and is believed to be essential for appropriate function of this system. However, how this precise connectivity is established...

  6. Accessory renal arteries in a Caribbean population: a computed tomography based study

    Johnson, Peter B.; Cawich, Shamir O.; Shah, Sundeep D; Aiken, William; McGregor, Roy G; Brown, Hilary; Gardner, Michael T.

    2013-01-01

    Introduction The commonest variation to the classic anatomic description of renal arterial supply is the presence of accessory renal arteries. The incidence varies widely according to ethnicity. There is no data on the prevalence of these anomalies in persons of Caribbean ethnicity. Methods All CT scans done over two years from July 1, 2010 to June 30, 2012 were retrospectively evaluated. The anatomy of the renal arterial supply was reported from these studies and the anatomy of accessory ren...

  7. Digital Branding and Multichannel Marketing : Engaging German Millennials : Lumi Accessories LTD

    Astikainen, Pauliina

    2015-01-01

    The purpose of this thesis was to create a multichannel marketing handbook for Lumi Accessories LTD. Lumi is a leading leather handbag, shoe, and accessories designer brand in Finland, which has strong ecological and sustainable values. The handbook was created especially for the marketing team to guide how digital branding can increase brand awareness among German Millennials so that the awareness of the new Lumi store will increase in Berlin. The aim was to identify measurable objectives, e...

  8. Accessory soleus muscle: a case report and clinical applicability

    William Paganini Mayer

    2013-10-01

    Full Text Available Variations in leg muscle are uncommon. Literature on this subject is scarce, but when those variations are reported they may cause alterations in joint mechanics or cause some discomfort in the leg and foot. The accessory soleus muscle (ASM is considered an unusual anatomical variation, with an  incidence of 0.5-6.0% in the population through studies in cadavers. During routine preparation of study material in the dissection room of the anatomy laboratory of the Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória/ES – Brazil, an ASM was found in the right inferior limb of a male cadaver fixed in 10% formalin. This supernumerary muscle was 3 cm wide, 9 cm long and 1 cm thick in its most voluminous part, in typical penniform fibers arrangement. It was located in the posteromedial region of the ankle, anterior to the Achilles tendon and posterior to the deep muscles of the leg compartment. Its anterior face covered the tibial nerve and the posterior tibial vessels, while its lower half was covered by the flexor retinaculum into the tarsal tunnel. Reports in the literature show possible compression of a neurovascular bundle because of its intimal position within the tarsal tunnel, which could result in ischemic compartment syndrome.

  9. Dynamic expression pattern of kinesin accessory protein in Drosophila

    Ritu Sarpal; Krishanu Ray

    2002-09-01

    We have identified the Drosophila homologue of the non-motor accessory subunit of kinesin-II motor complex. It is homologous to the SpKAP115 of the sea urchin, KAP3A and KAP3B of the mouse, and SMAP protein in humans. In situ hybridization using a DmKAP specific cRNA probe has revealed a dynamic pattern of expression in the developing nervous system. The staining first appears in a subset of cells in the embryonic central nervous system at stage 13 and continues till the first instar larva stage. At the third instar larva stage the staining gets restricted to a few cells in the optic lobe and in the ventral ganglion region. It has also stained a subset of sensory neurons from late stage 13 and till the first instar larva stage. The DmKAP expression pattern in the nervous system corresponds well with that of Klp64D and Klp68D as reported earlier. In addition, we have found that the DmKAP gene is constitutively expressed in the germline cells and in follicle cells during oogenesis. These cells are also stained using an antibody to KLP68D protein, but mRNA in situ hybridization using KLP64D specific probe has not stained these cells. Together these results proved a basis for further analysis of tissue specific function of DmKAP in future.

  10. Cummins MD & HD Accessory Hybridization CRADA -Annual Report FY15

    Deter, Dean D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-01

    There are many areas of MD and HD vehicles that can be improved by new technologies and optimized control strategies. Component optimization and idle reduction need to be addressed, this is best done by a two part approach that includes selecting the best component technology, and/or architecture, and optimized controls that are vehicle focused. While this is a common focus in the light duty industry it has been gaining momentum in the MD and HD market as the market gets more competitive and the regulations become more stringent. When looking into systems optimization and idle reduction technologies, affected vehicle systems must first be considered, and if possible included in the new architecture to get the most benefit out of these new capabilities. Typically, when looking into idle reduction or component optimization for MD/HD, the vehicle s accessories become a prime candidate for electrification or hybridization. While this has already been studied on light duty vehicles (especially on hybrids and electric vehicles) it has not made any head way or market penetration in most MD and HD applications. If hybrids and electric MD and HD vehicles begin to break into the market this would be a necessary step into the ability to make those vehicles successful by allowing for independent, optimized operation separate from the engine.

  11. Rock sealing - large scale field test and accessory investigations

    The experience from the pilot field test and the basic knowledge extracted from the lab experiments have formed the basis of the planning of a Large Scale Field Test. The intention is to find out how the 'instrument of rock sealing' can be applied to a number of practical cases, where cutting-off and redirection of groundwater flow in repositories are called for. Five field subtests, which are integrated mutually or with other Stripa projects (3D), are proposed. One of them concerns 'near-field' sealing, i.e. sealing of tunnel floors hosting deposition holes, while two involve sealing of 'disturbed' rock around tunnels. The fourth concerns sealing of a natural fracture zone in the 3D area, and this latter test has the expected spin-off effect of obtaining additional information on the general flow pattern around the northeastern wing of the 3D cross. The fifth test is an option of sealing structures in the Validation Drift. The longevity of major grout types is focussed on as the most important part of the 'Accessory Investigations', and detailed plans have been worked out for that purpose. It is foreseen that the continuation of the project, as outlined in this report, will yield suitable methods and grouts for effective and long-lasting sealing of rock for use at stategic points in repositories. (author)

  12. Various Tumor-Mimicking Lesions in the Musculoskeletal System: Causes and Diagnostic Approach

    Kim, Sue Yon; Park, Ji Seon; Ryu, Kyung Nam; Jin, Wook; Park, So Young

    2011-01-01

    Tumor-mimicking lesions in the musculoskeletal system can be defined as lesions mistaken as tumors due to the presence of palpation upon physical examination or a tumor-like appearance upon radiological examination. Moreover, tumor-mimicking lesions show diverse etiologies and anatomic locations. We illustrated the various tumor-mimicking lesions involving bone and soft tissue. In this review, the tumor-mimicking lesions were classified into those based on clinical examination and those based...

  13. The spleen and splenectomy in immune (idiopathic) thrombocytopenic purpura.

    Sandler, S G

    2000-01-01

    The benefits of surgical splenectomy in patients with immune (Idiopathic) thrombocytopenia purpura (ITP) probably reflect the combined effects of eliminating a source of antiplatelet antibody synthesis as well as the primary site of platelet destruction. The recent availability of intravenous Rho(D) Immune globulin (WinRho SDF; Nabi, Boca Raton, FL) presents an opportunity to extend the duration of nonsurgical (spleen-sparing) management of chronic ITP by inducing reversible Fc blockade. While new methods for laparoscopic splenectomy may offer improved surgical outcomes and reduced costs for ITP patients in the near-term, the long-term consequences of splenectomy remain to be determined. Partial splenectomy has been shown to be effective in the management of anemia in hereditary spherocytosis and elliptocytosis, while preserving vital splenic phagocytic and immune functions. The concept that cell destruction occurs in reticuloendothelial cells has been updated with recognition that the mononuclear phagocyte is neither a reticular nor an endothelial cell. Immune phagocytosis is now understood to be mediated by macrophage IgG Fc and complement receptors. A key factor for devising a strategy for selecting medical or surgical splenectomy, or postponing splenectomy, is an assessment of the relative importance of splenic immune versus phagocytic function in the pathogenesis of ITP. PMID:10676918

  14. Oncocytoma of Oral Cavity Mimicking as Jaw Tumor

    Aloke Bose Majumdar; Shib Shankar Paul; Gautam Sarker; Souradeep Ray

    2014-01-01

    Oncocytoma of major salivary gland is a fairly common benign tumour encountered, but its occurrence in oral minor salivary gland is a rare entity. Here we report a case of a giant minor salivary gland oncocytoma mimicking a jaw tumour which was successfully excised along with a review of literature.

  15. Spinal MRI of vincristine neuropathy mimicking Guillain-Barre syndrome

    A 4.3-year-old girl with acute leukaemia, who was being treated with chemotherapy (including vincristine), developed paraplegia. Spinal MRI showed diffusely enhancing nerve roots on contrast-enhanced images. Spinal fluid analysis showed a normal protein level. Vincristine neuropathy mimicking Guillain-Barre syndrome is thought to be the cause of the MRI abnormalities. (orig.)

  16. Spinal MRI of vincristine neuropathy mimicking Guillain-Barre syndrome

    Chang, Yun Woo; Yoon, Hye-Kyung; Cho, Jae Min [Department of Radiology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Kangnam-gu, Seoul 135-710 (Korea); Sung, Ki Woong [Department of Paediatrics, Samsung Medical Centre, Seoul 135-710 (Korea)

    2003-11-01

    A 4.3-year-old girl with acute leukaemia, who was being treated with chemotherapy (including vincristine), developed paraplegia. Spinal MRI showed diffusely enhancing nerve roots on contrast-enhanced images. Spinal fluid analysis showed a normal protein level. Vincristine neuropathy mimicking Guillain-Barre syndrome is thought to be the cause of the MRI abnormalities. (orig.)

  17. Bilateral multiple pulmonary tuberculous nodules mimicking metastatic disease

    We present CT findings of a young woman who has bilateral pulmonary nodules mimicking metastases. Clinical presentation with active multiple pulmonary macronodules without cavitation responsive to treatment is an atypical manifestation of pulmonary tuberculosis. We reviewed the causes of multiple pulmonary nodules, role of radiological findings in differential diagnosis and parenchymal manifestations of pulmonary tuberculosis in this report

  18. Ruptured Ovarian Dermoid Cyst Mimicking Peritoneal Carcinomatosis: CT and MRI

    Gurcan Erbay

    2016-01-01

    Spontaneous rupture of ovarian dermoid cyst and chronic abdominal spillage of its content is a very uncommon condition, which causes granulomatous peritonitis and can be confused with peritoneal carcinomatosis. Here is presented such a case of ruptured dermoid cyst causing chronic granulomatous peritonitis with radiologic findings mimicking peritoneal carcinomatosis.

  19. Peripancreatic Tuberculous Lymphadenopathy Mimicking Pancreatic Neoplasm: A Case Report

    Bae, Kyung Eun; Cho, Hyun Sun [Dept. of Radiology, Saggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of)

    2011-06-15

    Peripancreatic tuberculosis affecting only the lymph nodes is a rare clinical entity which usually raises serious diagnostic problems. We experienced a case of surgically proven peripancreatic tuberculous lymphadenopathy mimicking pancreas cystic neoplasm and report here on the findings of this rare condition along with a literature review.

  20. Peripancreatic Tuberculous Lymphadenopathy Mimicking Pancreatic Neoplasm: A Case Report

    Peripancreatic tuberculosis affecting only the lymph nodes is a rare clinical entity which usually raises serious diagnostic problems. We experienced a case of surgically proven peripancreatic tuberculous lymphadenopathy mimicking pancreas cystic neoplasm and report here on the findings of this rare condition along with a literature review.

  1. Severe cytomegalovirus colitis with hemolytic anemia mimicking travelers’ diarrhea

    Nakyoung Hwang

    2015-08-01

    Full Text Available A case of cytomegalovirus (CMV colitis mimicking travelers’ diarrhea following short-term travel is reported. The patient was a Croatian man visiting Korea for work. He presented with fever and severe bloody diarrhea. He was diagnosed with a primary CMV infection complicated with CMV colitis and hemolytic anemia and recovered with antiviral therapy and concomitant steroid therapy.

  2. Xanthogranulomatous Endometritis: An Unusual Pathological Entity Mimicking Endometrial Carcinoma

    Makkar, M; Gill, MK; Singh, DP

    2013-01-01

    Xanthogranulomatous endometritis is an unusual pathological entity mimicking endometrial carcinoma. This shows sheets of foamy histiocytes alongwith other inflammatory cells. We, hereby, report a case of 45 year multigravida female with irregular menstrual history, clinically diagnosed as carcinoma and histopathologically turned out as xanthogranulomatous endometritis. So, this condition should always be dealt with caution, and pathologists and clinicians should be aware of it.

  3. Intracranial Gossypiboma Mimicking a Recurrent Low Grade Astrocytoma : Case Report

    Lee, Jin Young; Koo, Joon Bum [Dept. of Radiology, Dongguk University Il-San Hospital, Iksan (Korea, Republic of)

    2011-05-15

    Gossypiboma is an inflammatory pseudomass formed by a retained surgical sponge or gauze with reactive tissue after surgery. Gossypiboma has been reported most frequently after abdominal or thoracic surgery. As such, gossypiboma following brain surgery is very rare. We report a case of gossypiboma mimicking tumor recurrence in the brain after a craniotomy and surgical excision of a low grade astrocytoma.

  4. MR imaging findings of painful type II accessory navicular bone: correlation with surgical and pathologic studies

    Choi, Yun Sun; Lee, Kyung Tai; Kim, Eun Kyung [Eulji Hospital, Eulji University School of Medicine, Daejeon (Korea, Republic of); Kang, Heung Sik [Seoul National University Bundang Hospital, Seoul (Korea, Republic of)

    2004-12-15

    To evaluate the MR imaging findings of painful type II accessory navicular bone and to correlate these with the surgical and pathologic findings. The MR images of 17 patients with medial foot pain and surgically proven type II accessory navicular abnormalities were reviewed. The changes of signal intensity in the accessory navicular, synchondrosis and adjacent soft tissue, the presence of synchondrosis widening, and posterior tibial tendon (PTT) pathology on the T1-weighted and fat-suppressed T2-weighted images were analyzed. The MR imaging findings were compared with the surgical and pathologic findings. The fat-suppressed T2-weighted images showed high signal intensity in the accessory navicular bones and synchondroses in all patients, and in the soft tissue in 11 (64.7%) of the 17 patients, as well as synchondrosis widening in 3 (17.6%) of the 17 patients. The MR images showed tendon pathology in 12 (75%) of the 16 patients with PTT dysfunction at surgery. The pathologic findings of 16 surgical specimens included areas of osteonecrosis with granulomatous inflammation, fibrosis and destruction of the cartilage cap. The MR imaging findings of painful type II accessory navicular bone are a persistent edema pattern in the accessory navicular bone and within the synchondrosis, indicating osteonecrosis, inflammation and destruction of the cartilage cap. Posterior tibial tendon dysfunction was clinically evident in most patients.

  5. MR imaging findings of painful type II accessory navicular bone: correlation with surgical and pathologic studies

    To evaluate the MR imaging findings of painful type II accessory navicular bone and to correlate these with the surgical and pathologic findings. The MR images of 17 patients with medial foot pain and surgically proven type II accessory navicular abnormalities were reviewed. The changes of signal intensity in the accessory navicular, synchondrosis and adjacent soft tissue, the presence of synchondrosis widening, and posterior tibial tendon (PTT) pathology on the T1-weighted and fat-suppressed T2-weighted images were analyzed. The MR imaging findings were compared with the surgical and pathologic findings. The fat-suppressed T2-weighted images showed high signal intensity in the accessory navicular bones and synchondroses in all patients, and in the soft tissue in 11 (64.7%) of the 17 patients, as well as synchondrosis widening in 3 (17.6%) of the 17 patients. The MR images showed tendon pathology in 12 (75%) of the 16 patients with PTT dysfunction at surgery. The pathologic findings of 16 surgical specimens included areas of osteonecrosis with granulomatous inflammation, fibrosis and destruction of the cartilage cap. The MR imaging findings of painful type II accessory navicular bone are a persistent edema pattern in the accessory navicular bone and within the synchondrosis, indicating osteonecrosis, inflammation and destruction of the cartilage cap. Posterior tibial tendon dysfunction was clinically evident in most patients

  6. Study on the pathological basis of classification of spleen deficiency in chronic gastritis

    尹光耀; 张武宁; 沈小静; 何雪芬; 陈一

    2004-01-01

    Background Spleen in Traditional Chinese Medicine (TCM) is not actually the spleen in the anatomic sense designated in western medicine because its functions basically belong to the physiological category of digestive system in modern medicine, and it represents a macroscopic concept of digestion, absorption and nutrition metabolism. Spleen deficiency syndrome refers to the clinical phenomena such as hypofunction of digestion, absorption and nutrition metabolism. By integrating TCM with modern medicine , this paper is intended to explore the pathological basis of classification of spleen deficiency in chronic gastritis.Method By means of optical microscope, scanning electron microscope (SEM), transmission electron microscope (TEM) and histochemical staining, we conducted histopathological and subcellular ultrastructural (nuclei and mitochondrial) analysis of gastric mucosa of 188 patients of spleen deficiency, and that of 42 voluntary blood donors without clinical symptoms. Results The gastric mucosa of patients with spleen Qi deficiency (SQD) and spleen yang deficiency (SyangD) could either be affected by organic lesion (type G-occurring on the basis of chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG)) or unaffected (type F-chiefly belonging to functional indigestion); spleen yin deficiency (SyinD) and spleen deficiency with Qi stagnation (SDQS) both occurred on the basis of CSG and CAG; and the degree of mucosa inflammatory cells infiltration, the degree of decrease in glands propria, and the incidence of IMⅡb in CSG and CAG were more serious than those of G-SQD and G-SyangD, P<0.05-0.01.Conclusion Spleen deficiency syndrome is likely to occur on the basis of organic lesion of gastric mucosa (disease with symptoms of both CSG or CAG and spleen deficiency symptoms), as well as on the basis of inorganic lesion of gastric mucosa (nondisease with symptoms, which is, despite spleen deficiency symptoms, there is no CSG or CAG). Besides, the

  7. Spleen size changes in children with homozygous. beta. -thalassaemia in relation to blood transfusion

    Karpathios, Th.; Antypas, A.; Dimitriou, P.; Nicolaidou, P.; Fretzayas, A.; Thomaidis, Th.; Matsaniotis, N. (First Department of Paediatrics of Athens University, Aghia Sophia Children' s Hospital, Athens, Greece and Department of Pathologic Physiology, University of Athens, Athens, Greece)

    1982-01-01

    18 thalassaemic children, aged 3.5 to 13 years comprise our clinical material. In 14 of them, clinically elicited spleen markings, haematocrit, blood platelet count and red cell morphology were studied daily for a whole period between 2 transfusions. In 10 patients considerable changes in spleen size were noticed. According to our clinical observations the spleen size starts decreasing 1 to 3 d after blood transfusion up to the 10th posttransfusion day fluctuating thereafter to reach its maximum size again prior to the next blood transfusion. The decrease of spleen size was followed by an increase of haematocrit and blood platelet count and vice versa. 4 additional children were studied clinically only twice: prior to and 7 to 10 d after blood transfusion. A definite decrease of the spleen size following blood transfusion was observed. Spleen and liver sup(99m)Tc-sulfur colloid uptake was studied in 10 of the above children prior to and 7 to 10 d after blood transfusion. Statistically significant post-transfusion increase of the spleen uptake was demonstrated. Our findings suggest that (a) splenic size is relevant to blood volume sequestered in this organ, (b) splenic radioactive uptake increases with its post-transfusion reduction in size.

  8. Spleen size changes in children with homozygous β-thalassaemia in relation to blood transfusion

    18 thalassaemic children, aged 3.5 to 13 years comprise our clinical material. In 14 of them, clinically elicited spleen markings, haematocrit, blood platelet count and red cell morphology were studied daily for a whole period between 2 transfusions. In 10 patients considerable changes in spleen size were noticed. According to our clinical observations the spleen size starts decreasing 1 to 3 d after blood transfusion up to the 10th posttransfusion day fluctuating thereafter to reach its maximum size again prior to the next blood transfusion. The decrease of spleen size was followed by an increase of haematocrit and blood platelet count and vice versa. 4 additional children were studied clinically only twice: prior to and 7 to 10 d after blood transfusion. A definite decrease of the spleen size following blood transfusion was observed. Spleen and liver sup(99m)Tc-sulfur colloid uptake was studied in 10 of the above children prior to and 7 to 10 d after blood transfusion. Statistically significant post-transfusion increase of the spleen uptake was demonstrated. Our findings suggest that (a) splenic size is relevant to blood volume sequestrated int this organ, (b) splenic radioactive uptake increases with its post-transfusion reductin in size. (author)

  9. Effect of Spleen Lymphocytes on the Splenomegaly in Hepatocellular Carcinoma-bearing Mice

    FANG Jing Jing; ZHU Zhen Yuan; DONG Hui; ZHENG Guo Qiang; TENG An Guo; LIU An Jun

    2014-01-01

    Objective To study the effect of spleen lymphocytes on the splenomegaly by hepatocellular carcinoma-bearing mouse model. Methods Cell counts, cell cycle distribution, the percentage of lymphocytes subsets and the levels of IL-2 were measured, and two-dimensional gel electrophoresis (2-DE) was used to investigate the relationship between spleen lymphocytes and splenomegaly in hepatocellular carcinoma-bearing mice. Results Compared with the normal group, the thymus was obviously atrophied and the spleen was significantly enlarged in the tumor-bearing group. Correlation study showed that the number of whole spleen cells was positively correlated with the splenic index. The cell diameter and cell-cycle phase distribution of splenocytes in the tumor-bearing group showed no significant difference compared to the normal group. The percentage of CD3+ T lymphocytes and CD8+ T lymphocytes in spleen and peripheral blood of tumor-bearing mice were substantially higher than that in the normal mice. Meanwhile, the IL-2 level was also higher in the tumor-bearing group than in the normal group. Furthermore, two dysregulated protein, β-actin and S100-A9 were identified in spleen lymphocytes from H22-bearing mice, which were closely related to cellular motility. Conclusion It is suggested that dysregulated β-actin and S100-A9 can result in recirculating T lymphocytes trapped in the spleen, which may explain the underlying cause of splenomegaly in H22-bearing mice.

  10. Factors influencing liver and spleen volume changes after donor hepatectomy for living donor liver transplantation

    Bae, Ji Hee; Ryeom, Hunku; Song, Jung Hup [Kyungpook National University Hospital, Daegu (Korea, Republic of)

    2013-11-15

    To define the changes in liver and spleen volumes in the early postoperative period after partial liver donation for living-donor liver transplantation (LDLT) and to determine factors that influence liver and spleen volume changes. 27 donors who underwent partial hepatectomy for LDLT were included in this study. The rates of liver and spleen volume change, measured with CT volumetry, were correlated with several factors. The analyzed factors included the indocyanine green (ICG) retention rate at 15 minutes after ICG administration, preoperative platelet count, preoperative liver and splenic volumes, resected liver volume, resected-to-whole liver volume ratio (LV{sub R}/LV{sub W}), resected liver volume to the sum of whole liver and spleen volume ratio [LV{sub R}/(LV{sub W} + SV{sub 0})], and pre and post hepatectomy portal venous pressures. In all hepatectomy donors, the volumes of the remnant liver and spleen were increased (increased rates, 59.5 ± 50.5%, 47.9 ± 22.6%). The increment rate of the remnant liver volume revealed a positive correlation with LV{sub R}/LV{sub W} (r = 0.759, p < 0.01). The other analyzed factors showed no correlation with changes in liver and spleen volumes. The spleen and remnant liver volumes were increased at CT volumetry performed 2 weeks after partial liver donation. Among the various analyzed factors, LV{sub R}/LV{sub W} influences the increment rate of the remnant liver volume.

  11. Nitric oxide production by murine spleen cells stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans.

    Sosroseno, Wihaskoro; Herminajeng, Endang; Susilowati, Heni; Budiarti, Sri

    2002-12-01

    The aim of this study was to determine whether Actinobacillus actinomycetemcomitans lipopolysaccharide (LPS-A. actinomycetemcomitans) could induce murine spleen cells to produce nitric oxide (NO). Spleen cells derived from Balb/c mice were stimulated with LPS-A. actinomycetemcomitans or LPS from Escherichia coli for 4 days. The effects of N(G)-monomethyl-L-arginine (NMMA), polymyxin B, and cytokines (IFN-gamma and IL-4) on the production of NO were also assessed. The NO production from the carrageenan-treated spleen cells stimulated with LPS-A. actinomycetemcomitans or both LPS-A. actinomycetemcomitans and IFN-gamma was determined. The carrageenan-treated mice were transferred with splenic macrophages and the NO production was assessed from the spleen cells stimulated with LPS-A. actinomycetemcomitans or LPS-A. actinomycetemcomitans and IFN-gamma. The results showed that NO production was detectable in the cultures of spleen cells stimulated with LPS-A. actinomycetemcomitans in a dose-dependent fashion, but was lower than in the cells stimulated with LPS from E. coli. The NO production was blocked by NMMA and polymyxin B. IFN-gamma up-regulated but IL-4 suppressed the production of NO by the spleen cells stimulated with LPS-A. actinomycetemcomitans. The carrageenan-treated spleen cells failed to produce NO after stimulation with LPS-A. actinomycetemcomitans or both LPS-A. actinomycetemcomitans and IFN-gamma. Adoptive transfer of splenic macrophages to the carrageenan-treated mice could restore the ability of the spleen cells to produce NO. The results of the present study suggest that LPS-A. actinomycetemcomitans under the regulatory control of cytokines induces murine spleen cells to produce NO and that splenic macrophages are the cellular source of the NO production. Therefore, these results may support the view that NO production by LPS-A. actinomycetemcomitans-stimulated macrophages may play a role in the course of periodontal diseases. PMID:16887678

  12. Radioprotective effects of dipyridamole. Effect on lipid peroxidation in mouse spleen after whole-body irradiation

    We have investigated the effects of dipyridamole, which has radioprotective effects in mice, on radiation damage in the mouse spleen. The level of thiobarbituric acid-reactive substances (TBARS) in the spleen, a measure of free radical initiated lipid peroxidation, increased significantly between 6 and 10 Gy 4 days after whole-body irradiation (p<0.05). Also, the TBARS in the spleen increased linearly between days 2 and 10 after 9 Gy whole-body irradiation. The TBARS concentration in the spleen 4 days after irradiation was reduced significantly from 5.15±0.97 nmole/mg protein to 3.76±0.35 nmole/mg protein by dipyridamole treatment (1hr before irradiation, 2 mg i.p.) (p<0.01), but no effects were observed with 2 mg i.p. dipyridamole treatment after irradiation. The weight of the spleen decreased significantly between 6 (31%) to 10 Gy (21%) 4 days after whole-body irradiation (p<0.05). The spleen weight 2 day after 9 Gy whole-body irradiation (40.2±1.8 mg) decreased significantly as compared with the control group (125.8±16.8 mg, p< O.01), and the decrease in spleen weight was related to the time lapse (after irradiation from 2 to 10 days). The slight inhibition effect on the decrease of spleen weight was observed by dipyridamole treatment 2 days after 9 Gy whole-body irradiation. These results suggest that the radioprotective effects of dipyridamole are related to the inhibition of lipid peroxidation and to participation in the early phase of apoptosis in spleen cells. (author)

  13. Tie2 Expressing Monocytes in the Spleen of Patients with Primary Myelofibrosis.

    Campanelli, Rita; Fois, Gabriela; Catarsi, Paolo; Poletto, Valentina; Villani, Laura; Erba, Benedetta Gaia; Maddaluno, Luigi; Jemos, Basilio; Salmoiraghi, Silvia; Guglielmelli, Paola; Abbonante, Vittorio; Di Buduo, Christian Andrea; Balduini, Alessandra; Iurlo, Alessandra; Barosi, Giovanni; Rosti, Vittorio; Massa, Margherita

    2016-01-01

    Primary myelofibrosis (PMF) is a Philadelphia-negative (Ph-) myeloproliferative disorder, showing abnormal CD34+ progenitor cell trafficking, splenomegaly, marrow fibrosis leading to extensive extramedullary haematopoiesis, and abnormal neoangiogenesis in either the bone marrow or the spleen. Monocytes expressing the angiopoietin-2 receptor (Tie2) have been shown to support abnormal angiogenic processes in solid tumors through a paracrine action that takes place in proximity to the vessels. In this study we investigated the frequency of Tie2 expressing monocytes in the spleen tissue samples of patients with PMF, and healthy subjects (CTRLs), and evaluated their possible role in favouring spleen angiogenesis. We show by confocal microscopy that in the spleen tissue of patients with PMF, but not of CTRLs, the most of the CD14+ cells are Tie2+ and are close to vessels; by flow cytometry, we found that Tie2 expressing monocytes were Tie2+CD14lowCD16brightCDL62-CCR2- (TEMs) and their frequency was higher (p = 0.008) in spleen tissue-derived mononuclear cells (MNCs) of patients with PMF than in spleen tissue-derived MNCs from CTRLs undergoing splenectomy for abdominal trauma. By in vitro angiogenesis assay we evidenced that conditioned medium of immunomagnetically selected spleen tissue derived CD14+ cells of patients with PMF induced a denser tube like net than that of CTRLs; in addition, CD14+Tie2+ cells sorted from spleen tissue derived single cell suspension of patients with PMF show a higher expression of genes involved in angiogenesis than that found in CTRLs. Our results document the enrichment of Tie2+ monocytes expressing angiogenic genes in the spleen of patients with PMF, suggesting a role for these cells in starting/maintaining the pathological angiogenesis in this organ. PMID:27281335

  14. New contrast material for CT of the liver and spleen

    A need exists for better contrast agents to improve the CT detection of hepatic abnormalities. Specially, delination of space-occupying lesions in the liver and demonstration of the relation between the hepatic lesions and vascular structures are important clinical problems. A contrast agent that is taken up by the hepatic parenchyma could be helpful in both of these tasks. Such an agent would selectively enhance only normal liver tissue, so that lesions lacking normal hepatocytes would stand out as filling defects. Non-ionic contrast materials have surface activity, because they have hydrophilic and hydrophobic groups in the same molecules. It was presumed that iodinated oil (Lipiodol Ultra-Fluid) emulsified by a non-ionic contrast material contains much more iodine in the colloid particles by absorbing a non-ionic contrast material on the surface of droplets. Iopamidol was chosen after comparison of ability of surface activity of these agents (Iopamidol, Iotrolan, Iohexol). 200 mg of iodine is absorbed by 1 ml of Lipiodol. Hemaeccel (Polymer of hydrolyzed gelatine with saline) was added as a stabilizer. A Total of 17 rabbits were scanned to evaluate the CT density of the liver, spleen, inferior vena cava and urinary bladder. Marked increase of the liver density is observed in the groups of intravenous administration of the contrast material, whereas, little increase of the vascular structure is observed. No acute toxity was observed. The extreme potency, excellent targeting, and apparent lack of toxicity of this agent suggest that iodinated oil emulsified by non-ionic contrast material probably will have a clinical application in the detection of focal hepatic and splenic lesions. (author)

  15. Infrahyoid and accessory motoneurons in the Japanese monkey (Macaca fuscata).

    Ueyama, T; Satoda, T; Tashiro, T; Sugimoto, T; Matsushima, R; Mizuno, N

    1990-01-15

    The segmental and topographical organization of motoneurons innervating the infrahyoid (IH) and the spinal accessory (AC) muscles was studied in the Japanese monkey (Macaca fuscata) with the retrograde horseradish peroxidase (HRP) method after application of HRP to the peripheral nerve branches supplying the IH and AC muscles. IH motoneurons constitute two distinct slender cell columns, a longer medial and a shorter lateral one. The medial cell column extends from the most caudal level of the hypoglossal nucleus to the lower levels of the second cervical (C2) cord segment. In the medial column, motoneurons supplying the sternohyoid and sternothyroid muscles are distributed at the medullary and C1 levels, while those innervating the omohyoid muscle are primarily distributed at the C2 level. The lateral cell column consists of motoneurons supplying the thyrohyoid muscle and extends from the most caudal level of the hypoglossal nucleus to the middle levels of the C1 cord segment. Axons of thyrohyoid motoneurons follow a dorsomedially directed bent emergent course, making a hairpin turn. AC motoneurons supplying the sternocleidomastoid (SC) and trapezius (TZ) muscles form a single slender cell column extending from the most rostral level of the pyramidal decussation to the middle levels of the C6 cord segment. SC motoneurons are distributed from the most rostral level of the pyramidal decussation to the middle levels of the C3 cord segment, while TZ motoneurons are distributed from the upper levels of the C2 cord segment to the lower levels of the C6 cord segment. At the levels of the C2 and C3 cord segments, both SC and TZ motoneurons are distributed in the AC cell column; the cluster of SC motoneurons is located dorsomedial to that of TZ motoneurons. PMID:2152765

  16. NATURAL FIBER REINFORCED POLYMER COMPOSITES FOR AUTOMOBILE ACCESSORIES

    D. Chandramohan

    2013-01-01

    Electron Microscope. The disclosure includes the process to make the composite and also the variety of products in automobile accessories.

  17. Anatomic landmarks for localization of the spinal accessory nerve.

    Durazzo, Marcelo D; Furlan, Julio C; Teixeira, Gilberto V; Friguglietti, Celso U M; Kulcsar, Marco A V; Magalhães, Roberto P; Ferraz, Alberto R; Brandão, Lenine G

    2009-05-01

    This anatomical study examines the anatomic topography and landmarks for localization of the spinal accessory nerve (SAN) during surgical dissections in 40 fresh human cadavers (2 females and 38 males; ages from 22 to 89 years with a mean of 60 years). In the submandibular region, the SAN was found anteriorly to the transverse process of the atlas in 77.5% of the dissections. When the SAN crossed the posterior belly of the digastric muscle, the mean distance from the point of crossing to the tendon of the muscle was 1.75 +/- 0.54 cm. Distally, the SAN crossed between the two heads of the SCM muscle in 45% of the dissections and deep to the muscle in 55%. The SAN exited the posterior border of the sternocleidomastoid muscle in a point superior to the nerve point with a mean distance between these two anatomic parameters of 0.97 +/- 0.46 cm. The mean overall extracranial length of the SAN was 12.02 +/- 2.32 cm, whereas the mean length of the SAN in the posterior triangle was 5.27 +/- 1.52 cm. There were 2-10 lymph nodes in the SAN chain. In conclusion, the nerve point is one of the most reliable anatomic landmarks for localization of the SAN in surgical neck dissections. Although other anatomic parameters including the transverse process of the atlas and the digastric muscle can also be used to localize the SAN, the surgeon should be aware of the possibility of anatomic variations of those parameters. Similar to previous investigations, our results suggest that the number of lymph nodes of the SAN chain greatly varies. PMID:19373901

  18. Expression of NALP3 in the Spleen of Mice with Portal Hypertension

    夏泽锋; 王国斌; 万赤丹; 刘涛; 王帅; 王博; 程锐

    2010-01-01

    This study examined the mRNA expression of NALP3 in the spleen of the mice with hypersplenism due to portal hypertension(PH).The mouse hypersplenism models were established by oral administration of tetrachloromethane(2 mL/kg/week for 12 weeks by oral gavage).All the mice were randomly divided into a control group and an experimental group.The blood routine test was conducted,spleen index was calculated and spleen was histologically examined.Portal vein sera were taken for detection of the level of uric aci...

  19. Size matters: Spleen and lung volumes predict performance in human apneic diving

    Erika eSchagatay

    2012-06-01

    Full Text Available Humans share with e.g. seals the ability to contract the spleen and increase circulating hematocrit, which may improve apneic performance by enhancing gas storage. Seals have large spleens and while human spleen size is small in comparison, it shows great individual variation. Unlike many marine mammals, human divers rely to a great extent on lung oxygen stores, but the impact of lung volume on competitive apnea performance has never been determined. We studied if spleen- and lung size correlated with performance in elite apnea divers. Volunteers were 14 male apnea world championship participants, with a mean(SE of 5.8(1.2 years of previous apnea training. Spleen volume was calculated from spleen length, width and thickness measured via ultrasound during rest, and vital capacity via spirometry. Accumulated competition scores from dives of maximal depth, time and distance were compared to anthropometric measurements and training data. Mean dive performance was 75(4 m for constant weight depth, 5 min 53(39 s for static apnea and 139(13 m for dynamic apnea distance. Subjects’ mean height was 184(2 cm, weight 82(3 kg, vital capacity (VC 7.3(0.3 L and spleen volume 336(32 ml. Spleen volume did not correlate with subject height or weight, but was positively correlated with competition score (r=0.57; P<0.05. Total competition score was also positively correlated with VC (r=0.54; P<0.05. The three highest scoring divers had the greatest spleen volumes, averaging 538(53 ml, while the three lowest scoring divers had a volume of 270(71 ml (P<0.01. VC was also greater in the high-scorers, at 7.9(0.36 L as compared to 6.7(0.19 L in the low-scorers (P<0.01. Spleen volume was reduced to half after 2 min of apnea in the highest scoring divers, and the estimated resting apnea time gain from the difference between high and low scorers was 15 s for spleen volume and 60 s for VC. We conclude that both spleen- and lung volume predict apnea performance in elite

  20. Computed tomography of the spleen and liver in sickle cell disease

    The spleen was assessed in 10 patients with sickle cell disease studied with computed tomography (CT) for abdominal pain and/or unexplained fever. Patients with homozygous sickle cell anemia were found to have small, densely calcified spleens with occasional low-density infarcts. Five of six had hepatomegaly, and there was one case each of hepatic abscess, infarcts, and hemochromatosis. All patients with heterozygous sickle cell disease were found to have splenomegaly, with a variety of findings including acute hemorrhage, acute and chronic infarcts, rupture, and possible sequestration. It was concluded that CT is useful for evaluating the status of the spleen and liver in symptomatic patients with sickle cell disease

  1. Inflammatory pseudotumor of the spleen: report of a case in a child

    We report a case of inflammatory pseudotumor of the spleen in a 4 years old child. Clinical findings were limited to diffuse abdominal pain and a palpable mass at the left hypochondrium. Ultrasonography and CT revealed a solid homogeneous mass in the lower pole of the spleen, with irregular enhancement with IV contrast. Laparoscopic splenectomy was performed. The diagnosis was histological. The pseudotumor of the spleen is extremely rare, especially in children, with only 4 cases (including our own) reported in the literature. Our patient constitutes the youngest case ever reported. (author)

  2. Non-Traumatic Subcapsular Spleen Hematoma in a Patient with Brucellosis

    Murat Söker

    2005-01-01

    Full Text Available Brucellosis is a zoonotic disease. A characteristic clinical findings are fever, headache, arthralgia and splenomegali. Brucellosis occurs after direct contact with an infected animal or consumption of products of an infected animal. Subcapsular hematoma in the spleen is very rare complication of brucella infection. We report here, an 11 year old patient with brucellosis who admitted to our clinic with subcapsular non-traumatic spleen hematoma. Hematoma and clinical findings were resolved with doxicyclin and streptomycin combination. We emphasised that brucella infection should be keept in mind when non-traumatic subcapsular spleen hematoma occur.

  3. Knowledge of the anatomy and physiology of the spleen throughout Antiquity and the Early Middle Ages.

    Paraskevas, George K; Koutsouflianiotis, Konstantinos N; Nitsa, Zoi; Demesticha, Theano; Skandalakis, Panagiotis

    2016-01-01

    The evolution of knowledge regarding the anatomy and physiology of the spleen throughout Antiquity and the Early Middle Ages is described, and general perceptions about this organ during different eras along this time line are presented. The original words of great physicians from the period of time stretching from Ancient Egypt to the Avicennan era are quoted and discussed to demonstrate how knowledge of the spleen has evolved and to present the theories that dominated each era. Furthermore, theories about illnesses relating to the spleen are reported, which show how this organ was perceived-in terms of its function and anatomy-during each era. PMID:26507317

  4. Active suppression of in vitro reactivity of spleen cells after BCG treatment

    It was found that spleen cells from mice injected i.v. with large doses of BCG responded to PHA stimulation less intensely than did normal spleen cells. It was shown that nylon wool column purified BCG treated T cells also had a low PHA reactivity. Unfractionated spleen cells, adherent cells or T-enriched populations from BCG treated mice, when added to normal T cells lowered their PHA reactivity. When the same BCG treated cell populations were added to tumor cells in vitro, they inhibited their growth. (author)

  5. Recognition of malposition of the liver and spleen: CT, MRI, nuclear scan and fluoroscopic imaging

    Newman, B. (Dept. of Radiology, Univ. of Pittsburgh School of Medicine, PA (United States) Children' s Hospital of Pittsburgh, PA (United States)); Bowen, A. (Dept. of Radiology, Univ. of Pittsburgh School of Medicine, PA (United States) Children' s Hospital of Pittsburgh, PA (United States)); Eggli, K.D. (Dept. of Radiology, Pennsylvania State Univ., Milton S. Hershey Medical Center, Hershey, PA (United States))

    1994-08-01

    Thirteen children initially suspected to have an intrathoracic or intraabdominal mass had malposition of the liver and/or spleen discovered by ultrasound. This group consisted of five children with diaphragmatic eventration or hernia and eight with wandering spleen or liver. Careful ultrasonographic examinations were diagnostic in all patients; seven had surgical confirmation. CT, MRI, nuclear scan and fluorescopic imaging were useful in select instances. The liver and spleen have a characteristic anatomic configuration and sonographic appearance that should enable them to be recognized, and pathological alterations appreciated, even when these organs are ectopic in location or malformed. (orig.)

  6. Recognition of malposition of the liver and spleen: CT, MRI, nuclear scan and fluoroscopic imaging

    Thirteen children initially suspected to have an intrathoracic or intraabdominal mass had malposition of the liver and/or spleen discovered by ultrasound. This group consisted of five children with diaphragmatic eventration or hernia and eight with wandering spleen or liver. Careful ultrasonographic examinations were diagnostic in all patients; seven had surgical confirmation. CT, MRI, nuclear scan and fluorescopic imaging were useful in select instances. The liver and spleen have a characteristic anatomic configuration and sonographic appearance that should enable them to be recognized, and pathological alterations appreciated, even when these organs are ectopic in location or malformed. (orig.)

  7. Regeneration of hemopoietic precursor cells in spleen organ cultures from irradiated mice: influence of genotype of cells injected and of the spleen microenvironment

    The regeneration of hemopoietic precursor cells was monitored in spleen organ cultures from lethally irradiated mice injected with 10(7) normal syngeneic or allogeneic bone marrow cells. The important role of the microenvironment in supporting hemopoiesis was confirmed by the failure of mutant Sl/Sld spleens to support CFC regeneration in organ cultures. However, the extent and quality of the CFC regeneration was clearly dependent on the genetic properties of the injected cells. Evidence for this was obtained from the regeneration patterns of various CFC types in organ cultured spleens derived from different mouse donor-recipient strain combinations that maintained the differences in the bone marrow frequency of various CFC types characteristic of the donor strain

  8. Incremental value of single photon emission tomography/computed tomography in 3-phase bone scintigraphy of an accessory navicular bone

    Jain, Sachin; Karunanithi, Sellam; Agarwal, Krishan Kant; Kumar, Ganesh; Roy, Shambo Guha; Tripathi, Madhavi

    2014-01-01

    Accessory navicular bone is one of the supernumerary ossicles in the foot. Radiography is non diagnostic in symptomatic cases. Accessory navicular has been reported as a cause of foot pain and is usually associated with flat foot. Increased radio tracer uptake on bone scan is found to be more sensitive. We report a case highlighting the significance of single photon emission tomography/computed tomography in methylene diphosphonate bone scan in the evaluation of symptomatic accessory navicula...

  9. Permanent junctional reciprocating tachycardia in a patient with an atypically located accessory pathway in the left lateral mitral annulus.

    Rodríguez-Mañero, Moisés; Fernández-López, Xesús A; González-Melchor, Laila; García-Seara, Javier; Martínez-Sande, Jose Luis; González-Juanatey, José Ramón

    2016-01-01

    Permanent junctional reciprocating tachycardia (PJRT) is an uncommon form of atrioventricular reentrant tachycardia due to an accessory pathway characterized by slow and decremental retrograde conduction. The majority of accessory pathways in PJRT are located in the posteroseptal zone. Few cases of atypical location have been described. We report a case of PJRT in a 72-year-old woman in whom the accessory pathway was located in the left lateral region and treated by radiofrequency catheter ablation. PMID:26749575

  10. Motoneuron organisation of the muscles of the spinal accessory complex of the sheep investigated with the fluorescent retrograde tracer technique.

    P. Clavenzani; Scapolo, P A; Callegari, E; Barazzoni, A M; Petrosino, G.; Lucchi, M L; Bortolami, R

    1994-01-01

    Retrograde transport of the fluorescent tracers Diamidino Yellow dihydrochloride and Fast Blue was used to determine the location of the spinal nucleus of the accessory nerve in the sheep. We also considered whether in this species the sternocephalic, brachiocephalic, omotransversarius and trapezius muscles, i.e. the muscles of the spinal accessory complex, are supplied by more than one population of motoneurons. The spinal accessory nucleus extends as a single column of neurons from C1 to C7...

  11. JAK2 inhibitors do not affect stem cells present in the spleens of patients with myelofibrosis

    Wang, Xiaoli; Ye, Fei; Tripodi, Joseph; Hu, Cing Siang; Qiu, Jiajing; Najfeld, Vesna; Novak, Jesse; Li, Yan; Rampal, Raajit; Hoffman, Ronald

    2014-01-01

    JAK2 inhibitors affect more mature MF progenitors, but spare disease-initiating stem cells.Reduction in spleen size achieved with JAK2 inhibitor therapy in MF can be attributed to depletion of a subpopulation of MF progenitors.

  12. The effect of age on apparent diffusion coefficient values in normal spleen: A preliminary study

    Aim: To investigate and characterize the effect of age on apparent diffusion coefficient (ADC) values in normal spleen. Materials and methods: A population of 127 patients (age range 10–79 years, mean age 44.4 years) without magnetic resonance imaging findings in abdominal scans, was selected over a 5-year period. The ADC values of the spleen were analysed in all ages, and dependency of ADC values on age was characterized using Spearman's correlation coefficient test. Results: A reduction of ADC values with ageing was found in the spleen (r = −0.702, p < 0.001). Conclusions: The ADC values of the spleen decline with age. This should be taken into consideration when disease is diagnosed

  13. Imaging findings in Langerhans' cell histiocytosis of the liver and the spleen in an adult

    We present a case of Langerhans' cell histiocytosis (LCH) of the liver and spleen in an adult. The imaging features are different from those in the few previously reported cases of individual organ involvement by LCH. (orig.) (orig.)

  14. The effect of abdominal radiation on spleen function: A study in children with Wilms' tumor

    Reports of splenic dysfunction in patients with Hodgkin's disease who received radiation therapy to the spleen raise questions concerning impairment of splenic function and the long-term risk of bacterial sepsis in children who receive abdominal radiation for other diseases. Splenic function was studied in 20 children with Wilms' tumor using a quantitative assessment of vacuolated (pitted) red cells as a measure of reticuloendothelial function. Fourteen children had received abdominal radiation to a field involving the spleen at a median dose of 2000 rads. Their pitted red cells counts were no different from those of 6 children who received therapy without radiation to the spleen or to those of a group of normal children and adults. We conclude that there is no demonstrable long-term impairment of spleen function with radiation doses at or below 2200 rads

  15. Imaging of liver and spleen candidiasis in patients with acute leukemia

    Seino, Yasuo; Tamakawa, Y.; Kato, T.; Kimura, Y.; Miyazaki, S.; Miura, R.; Ishida, H.

    1988-01-01

    Four patients with acute leukemia were found to have candidal abscess of liver and spleen. CT and US showed hepatosplenomegaly and microabscess. These findings might be useful in diagnosis of visceral candidiasis.

  16. Imaging of liver and spleen candidiasis in patients with acute leukemia

    Four patients with acute leukemia were found to have candidal abscess of liver and spleen. CT and US showed hepatosplenomegaly and microabscess. These findings might be useful in diagnosis of visceral candidiasis. (author)

  17. Granuloma inguinale mimicking as squamous cell carcinoma of penis

    Abhishek Pilani

    2014-01-01

    Full Text Available Granuloma inguinale (GI is an acquired chronic, slowly progressive, mildly contagious disease of venereal origin, characterized by granulomatous ulceration of the genitalia and neighboring sites, with little or no tendency to spontaneous healing caused by Klebsiella (Calymmatobacterium granulomatis. A 55-year-old male presented with fissured, foul smelling, fungating growth over prepuce with phimosis mimicking squamous cell carcinoma (SCC without lymphadenopathy. It started with painless papulonodular showed pseudoepitheliomatous hyperplasia, infiltration in dermis, acanthosis and vacuolated macrophages suggestive of GI and not showing any histopathological features of SCC. Patient was successfully treated by giving cotrimoxazole twice a day for 21 days. Here, we presented a case of GI mimicking SCC of penis, which was diagnosed on basis of histopathology and treated with excision followed by medical therapy with cotrimoxazole.

  18. Rational Design of Pathogen-Mimicking Amphiphilic Materials as Nanoadjuvants

    Ulery, Bret D.; Petersen, Latrisha K.; Phanse, Yashdeep; Kong, Chang Sun; Broderick, Scott R.; Kumar, Devender; Ramer-Tait, Amanda E.; Carrillo-Conde, Brenda; Rajan, Krishna; Wannemuehler, Michael J.; Bellaire, Bryan H.; Metzger, Dennis W.; Narasimhan, Balaji

    2011-12-01

    An opportunity exists today for cross-cutting research utilizing advances in materials science, immunology, microbial pathogenesis, and computational analysis to effectively design the next generation of adjuvants and vaccines. This study integrates these advances into a bottom-up approach for the molecular design of nanoadjuvants capable of mimicking the immune response induced by a natural infection but without the toxic side effects. Biodegradable amphiphilic polyanhydrides possess the unique ability to mimic pathogens and pathogen associated molecular patterns with respect to persisting within and activating immune cells, respectively. The molecular properties responsible for the pathogen-mimicking abilities of these materials have been identified. The value of using polyanhydride nanovaccines was demonstrated by the induction of long-lived protection against a lethal challenge of Yersinia pestis following a single administration ten months earlier. This approach has the tantalizing potential to catalyze the development of next generation vaccines against diseases caused by emerging and re-emerging pathogens.

  19. Toll-Like Receptor and Accessory Molecule mRNA Expression in Humans and Mice as Well as in Murine Autoimmunity, Transient Inflammation, and Progressive Fibrosis

    Hans-Joachim Anders

    2013-06-01

    Full Text Available The cell type-, organ-, and species-specific expression of the Toll-like receptors (TLRs are well described, but little is known about the respective expression profiles of their accessory molecules. We therefore determined the mRNA expression levels of LBP, MD2, CD36, CD14, granulin, HMGB1, LL37, GRP94, UNC93b1, TRIL, PRAT4A, AP3B1, AEP and the respective TLRs in human and mouse solid organs. Humans and mice displayed significant differences between their respective mRNA expression patterns of these factors. In addition, the expression profiles in transient tissue inflammation upon renal ischemia-reperfusion injury, in spleens and kidneys from mice with lupus-like systemic autoimmunity, and in progressive tissue fibrosis upon unilateral ureteral obstruction were studied. Several TLR co-factors were specifically regulated during the different phases of these disease entities, suggesting a functional involvement in the disease process. Thus, the organ- and species-specific expression patterns need to be considered in the design and interpretation of studies related to TLR-mediated innate immunity, which seems to be involved in the tissue injury phase, in the phase of tissue regeneration, and in progressive tissue remodelling.

  20. Study on the pathophysiologic basis of classification of 'spleen' deficiency in chronic gastritis

    YIN Guang-yao; CHEN Yi; SHEN Xiao-jing; HE Xue-fen; ZHANG Wu-ning

    2005-01-01

    Background Most of the studies on traditional Chinese medicine (TCM)‘spleen’deficiency syndrome in the recent 30 years were conducted only on the basis of single functional index, neglecting the study on the pathophysiologic internal relationship between spleen deficiency syndrome and gastric diseases in modern medicine. But it was at the subcellular molecular biological level that we explored the pathophysiologic basis of classification of spleen deficiency in chronic gastritis by detecting the bioactive substances in gastric mucosa nuclei and mitochondria. Methods By means of optical microscope, scanning electron microscope (SEM), transmission electron microscopy (TEM) and histochemical staining, we conducted histopathological, subcellular ultrastructural analysis and nuclei and mitochondrial ultrastructural analysis of gastric mucosa of 188 spleen deficiency patients and of 42 voluntary blood donors. At the same time, bioactive substances were measured by means of X-ray energy dispersive analysis system (EDAX) image analysis system, radioimmunoassay method and chemiluminescence method. Results The content of cAMP, superoxide dismutase (SOD), Zn and Cu in gastric mucosa, and the content of Zn and Cu in mitochondria decreased progressively in order of groups: healthy control (HC), spleen Qi deficiency without organic lesion (F-SQD), spleen Yang deficiency without organic lesion (F-SyangD), disease without symptoms group, spleen Qi deficiency with organic lesion (G-SQD), spleen Yang deficiency with organic lesion (G-SyangD), spleen Yin deficiency (SyinD) and spleen deficiency with Qi stagnation (SDQS), chronic spleen deficiency gastritis (CSG) and chronic atrophic gastritis (CAG); decreased in order of HC, intestinal metaplasia (IM)Ⅰa, IMⅠb, IMⅡa and IMⅡb, P<0.05. The content of DNA, Zn and Cu in nuclei progressively increased in order mentioned above, P<0.05.Conclusions The quantitative changes of gastric mucosal cAMP, SOD, Zn, Cu, of mitochondrial Zn

  1. Localization of an accessory helicase at the replisome is critical in sustaining efficient genome duplication.

    Atkinson, John; Gupta, Milind K; Rudolph, Christian J; Bell, Hazel; Lloyd, Robert G; McGlynn, Peter

    2011-02-01

    Genome duplication requires accessory helicases to displace proteins ahead of advancing replication forks. Escherichia coli contains three helicases, Rep, UvrD and DinG, that might promote replication of protein-bound DNA. One of these helicases, Rep, also interacts with the replicative helicase DnaB. We demonstrate that Rep is the only putative accessory helicase whose absence results in an increased chromosome duplication time. We show also that the interaction between Rep and DnaB is required for Rep to maintain rapid genome duplication. Furthermore, this Rep-DnaB interaction is critical in minimizing the need for both recombinational processing of blocked replication forks and replisome reassembly, indicating that colocalization of Rep and DnaB minimizes stalling and subsequent inactivation of replication forks. These data indicate that E. coli contains only one helicase that acts as an accessory motor at the fork in wild-type cells, that such an activity is critical for the maintenance of rapid genome duplication and that colocalization with the replisome is crucial for this function. Given that the only other characterized accessory motor, Saccharomyces cerevisiae Rrm3p, associates physically with the replisome, our demonstration of the functional importance of such an association indicates that colocalization may be a conserved feature of accessory replicative motors. PMID:20923786

  2. Osteofibrous dysplasia of clavicle clinically mimicking chronic osteomyelitis

    Nirmal Raj Gopinathan

    2016-01-01

    Full Text Available Osteofibrous dysplasia or ossifying fibroma is an uncommon benign fibro-osseous lesion of childhood, commonly described in the maxilla and the mandible. Among long bones, it usually presents in the tibia as a painless swelling or anterior bowing. Ossifying fibroma of clavicle has never been reported in English literature, to the best of our knowledge. Here, we would like to present an unusual case of osteofibrous dysplasia of clavicle clinically mimicking chronic osteomyelitis.

  3. Sarcoidosis mimicking metastatic thyroid cancer following radioactive iodine therapy

    Myint, Zin W.; Chow, Robert D.

    2015-01-01

    Introduction: Sarcoidosis is an inflammatory disease characterized by non-caseating granulomas that can be present in diverse organ systems. Sarcoidosis can be associated with malignancy, presenting either preceding, during, or after chemotherapy. We herewith report a case of sarcoidosis mimicking cancer recurrence that developed after radioactive iodine therapy for papillary thyroid cancer.Background: A 68-year-old Caucasian woman was found to have an incidental mediastinal lymph node. She u...

  4. Granuloma inguinale mimicking as squamous cell carcinoma of penis

    Abhishek Pilani; Rita Vora; Gopikrishnan Anjaneyan

    2014-01-01

    Granuloma inguinale (GI) is an acquired chronic, slowly progressive, mildly contagious disease of venereal origin, characterized by granulomatous ulceration of the genitalia and neighboring sites, with little or no tendency to spontaneous healing caused by Klebsiella (Calymmatobacterium) granulomatis. A 55-year-old male presented with fissured, foul smelling, fungating growth over prepuce with phimosis mimicking squamous cell carcinoma (SCC) without lymphadenopathy. It started with painless p...

  5. Heterotopic Pancreas Mimicking Cholangiocarcinoma. Case Report and Literature Review

    Atindriya Biswas; Ehab A. Husain; Roger M Feakins; Abraham, Ajit T

    2007-01-01

    Context Majority of the patients developing obstructive jaundice have an underlying malignancy. Identification of a benign pathology like heterotopic pancreas as an aetiology is uncommon and usually occurs only subsequent to a major operation. Case report We report a case of heterotopic pancreas adjacent to the ampulla of Vater mimicking distal cholangiocarcinoma. A 47- year-old patient presented with abdominal pain and obstructive jaundice. ERCP demonstrated a distal common bile duct strictu...

  6. Traumatic Thumb Radial Sagittal Band Injury Mimicking EPL Rupture.

    Dissanayake, Ravi M; Moore, Peter; McCarten, Gregory M

    2016-06-01

    We present the case of a closed traumatic disruption of the thumb radial sagittal band (RSB) that sonographically mimicked rupture of the extensor pollicis longus (EPL) tendon. This injury was treated with primary repair of the RSB and lead to a good functional outcome for the patient. This case report highlights how early recognition and treatment can lead to a good functional outcome. PMID:27454647

  7. A Case of Hidroacanthoma Simplex Mimicking Bowen s Disease

    Pinar Ozuguz

    2013-10-01

    Full Text Available Hidroacanthoma simplex is a rare benign tumor that originates from eccrine sweet gland ducts. The lesions are characterized by slowly-growing, flat or slightly elevated, skin-colored, brown or erythematous, verrucous papules or plaques. Clinically, plaques may resemble seborrheic keratosis, basal cell carcinoma and Bowen%u2019s disease. Here, we present a case of atypically localized hidroacanthoma simplex mimicking Bowen%u2019s disease.

  8. A Case of Hidroacanthoma Simplex Mimicking Bowen s Disease

    Pinar Ozuguz

    2013-01-01

    Hidroacanthoma simplex is a rare benign tumor that originates from eccrine sweet gland ducts. The lesions are characterized by slowly-growing, flat or slightly elevated, skin-colored, brown or erythematous, verrucous papules or plaques. Clinically, plaques may resemble seborrheic keratosis, basal cell carcinoma and Bowen%u2019s disease. Here, we present a case of atypically localized hidroacanthoma simplex mimicking Bowen%u2019s disease.

  9. Osteolytic nasal polyp of the maxillary sinus mimicking malignancy

    Arvind Karikal; Sampathila Mahalinga Sharma; Anju Gopinath; Arathi Karikal

    2014-01-01

    We present an osteolytic nasal polyp of the maxillary sinus with clinical features and radiographic features mimicking that of a malignancy. Maxillary sinusitis being a common inflammatory condition progressed to cause destruction of the maxillary bone and spread into the facial soft tissue, which is quite a rare occurrence. We have discussed in detail the clinical, radiological, histopathology and management of this uncommon presentation of a common case.

  10. Biliary Ascariasis Mimicking Colonic Tumor Infiltration of the Biliary System.

    Sundriyal, Deepak; Mittal, Gyanendra; Kumar, Sushil; Manjunath, Suraj; Sharma, Navneet; Gupta, Mahesh

    2015-09-01

    Ascariasis is a common problem in developing countries with poor hygiene and sanitation. It is endemic in India and usually seen in the northern states. Biliary ascariasis is an uncommon cause of obstructive jaundice. We present a case of carcinoma of hepatic flexure of colon in which the patient developed biliary ascariasis and posed a diagnostic challenge as it mimicked tumor infiltration of the biliary system. PMID:27217679

  11. Bartonella henselae Infection: An Uncommon Mimicker of Autoimmune Disease

    Maritsi, Despoina N.; Diagoras Zarganis; Zoi Metaxa; Georgia Papaioannou; George Vartzelis

    2013-01-01

    We present a case of a seven-year-old immunocompetent female patient who developed systemic symptoms mimicking an autoimmune rather than an infectious disease. The patient presented with rash, biquotidian fever, night sweats, and arthralgias. There was no antecedent history of cat contact. Investigations showed increased inflammatory markers, leukocytosis, thrombocytosis, hypercalcemia, and raised angiotensin-converting enzyme. Interferon-gamma releasing assay for tuberculosis infection was n...

  12. Resistance of Neonatal Mice to Scrapie Is Associated with Inefficient Infection of the Immature Spleen

    Ierna, Michelle; Farquhar, Christine F.; Outram, George W.; Bruce, Moira E.

    2006-01-01

    Previous studies demonstrated that neonatal mice up to about a week old are less susceptible than adult mice to infection by intraperitoneal inoculation with mouse-passaged scrapie. In peripherally inoculated adult mice, scrapie replicates in lymphoid tissues such as the spleen before invading the central nervous system. Here, we investigated scrapie susceptibility in neonatal mice in more detail, concentrating on spleen involvement. First, we demonstrated that neonatal mice are about 10 time...

  13. Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen

    Ma, Shihui; Shi, Yingxu; Pang, Yakun; Dong, Fang; Cheng, Hui; Hao, Sha; Xu, Jing; Zhu, Xiaofan; Yuan, Weiping; Cheng, Tao; Zheng, Guoguang

    2014-01-01

    Background Leukemia is a systemic malignancy originated from hematopoietic cells. The extracellular environment has great impacts on the survival, proliferation and dissemination of leukemia cells. The spleen is an important organ for extramedullary hematopoiesis and a common infiltration site in lymphoid malignancies. Splenomegaly, frequently observed in T cell acute lymphoblastic leukemia (T-ALL), is associated with poor prognosis. However, how the spleen microenvironment distinctly affects...

  14. Computed tomography of the abdomen in Saanen goats: II. liver, spleen, abomasum, and intestine

    Braun, U.; Irmer, M. (Matthias); Augsburger, H; Müller, U; Jud, R.; Ohlerth, S

    2011-01-01

    This study describes the results of computed tomography (CT) of the liver, spleen, abomasum, small intestine and large intestine in 30 healthy Saanen goats. CT examination and anatomical slice preparation postmortem were performed as described in the first communication. After subjective evaluation of the CT images, various variables including the length/size, volume and density of the liver, spleen and gallbladder, the wall thickness of the abomasum, small intestine and large intestine and t...

  15. Regulation of murine macrophage Ia-antigen expression by products of activated spleen cells

    1980-01-01

    This investigation examined the effects of mediators derived form activated spleen cells on macrophage Ia-antigen expression and function. Incubation of adherent thioglycollate-induced murine peritoneal macrophages(> 90% Ia-) with concanavalin A (Con A)- stimulated spleen cell supernate (Con A sup) resulted in a dose- dependent increase in the percentage of Ia-containing (Ia+) phagocytic cells, as detected by antiserum-and-complement-mediated cytotoxicity. The Ia-antigen expression of macroph...

  16. EFFECT OF SEDATION ON CONTRAST-ENHANCED ULTRASONOGRAPHY OF THE SPLEEN IN HEALTHY DOGS.

    Rossi, Federica; Fina, Caroline; Stock, Emmelie; Vanderperren, Katrien; Duchateau, Luc; Saunders, Jimmy H

    2016-05-01

    Contrast-enhanced ultrasound of the spleen enables the dynamic assessment of the perfusion of this organ, however, both subjective and quantitative evaluation can be strongly influenced by sedative agent administration. The purpose of this prospective, experimental study was to test effects of two sedative agents on splenic perfusion during contrast-enhanced ultrasound of the spleen in a sample of healthy dogs. Contrast-enhanced ultrasound of the spleen was repeated in six healthy Beagles following a cross-over study design comparing three protocols: awake, butorphanol 0.2 mg/Kg intramuscular (IM), and dexmedetomidine 500 μg/m(2) IM. After intravenous injection of a phospholipid stabilized sulfur hexafluoride microbubble solution (SonoVue®, Bracco Imaging, Milano, Italy), the enhancement intensity and perfusion pattern of the splenic parenchyma were assessed and perfusion parameters were calculated. Normal spleen was slightly heterogeneous in the early phase, but the parenchyma was homogeneous at a later phase. Sedation with butorphanol did not modify perfusion of the spleen. Dexmedetomidine significantly reduced splenic enhancement, providing diffuse parenchymal hypoechogenicity during the entire examination. Measured parameters were significantly modified, with increased arrival time (AT; (wash-in (P = 0.0014), and area under the curve (AUC; P = 0.0421). Findings supported the use of butorphanol and contraindicated the use of dexmedetomidine as sedatives for splenic contrast ultrasound procedures in dogs. Short-term and diffuse heterogeneity of the spleen in the early venous phase was determined to be a normal finding. PMID:26777031

  17. Correlation between contrast enhancement of portal vein and spleen size in dual-phase spiral CT

    To evaluate using spiral CT the effect of spleen size on blood flow in the portal venous system and to know the usefulness of this evaluation. Fifty-one patients without evidence on spiral CT scan of abnormality thought to affect portal venous flow presented between December 1994 and June 1995. We measured spleen size and Hounsfield units of portal vein in dual-phase, and calculated the ratio of the unit in the portal phase to that in the arterial phase. Spleen size was measured, using the length of X-axis by that of Z-axis on spiral CT scan. We then measured the correlation between the two values. CT was performed with a Somatom Plus-S scanner(Siemens, Erlangen, Germany). A total dose of 120ml of non-ionic contrast material(Ultravist) was administered at a rate of 3 ml/sec. Arterial and portal phase were obtained after 30 seconds and 60 seconds from the begining of the contrast agent injection. The correlation between spleen size and contrast enhancement of the portal vein was relatively significant(Pearson's correlation coefficient(r)=0.41801). Spleen size significantly affects portal venous flow on spiral CT scan. The evaluation of spleen size and contrast enhancement of the portal vein could be useful in the differential diagnosis of diseases which affect portal venous flow

  18. Spleen in sickle cell anemia: comparative studies of Nigerian and U.S. patients.

    Adekile, A D; McKie, K M; Adeodu, O O; Sulzer, A J; Liu, J S; McKie, V C; Kutlar, F; Ramachandran, M; Kaine, W; Akenzua, G I

    1993-03-01

    Anecdotal reports have attributed persistent splenomegaly in African sickle cell anemia (SS) patients to the effects of malaria. However, no comparative studies of patients in malarial and nonmalarial regions have been conducted, and few studies of malaria antibody titers have been reported. In the present study, age- and sex-matched Nigerian patients (n = 310), while it was found only in 8% of U.S. patients (n = 100) from Georgia. There was significant linear correlation between spleen size and Hb levels and with serum immunoglobulins in the Nigerian group. However, serum complement levels (C3 and C4) were not affected by spleen size. In both groups, patients with splenomegaly had fewer circulating pitted red cells than their counterparts without splenomegaly. The mean +/- SE of IgG-specific malaria antibody titer among the Nigerian patients without palpable spleens was 9,386 +/- 2,036; 9,334 +/- 2,980 in those with spleens between 1 and 5 cm, 16,201 +/- 4,502 in those with spleens between 6 and 10 cm, and 22,445 +/- 8,456 in those with spleens above 10 cm. Coexistent alpha-thalassemia did not influence the prevalence of splenomegaly among the Nigerian SS patients. This study provides additional evidence that malaria plays a significant role in the persistence of splenomegaly in African patients. PMID:8438905

  19. Age dependence of spleen- and muscle-corrected hepatic signal enhancement on hepatobiliary phase gadoxetate MRI

    Matoori, Simon [Paracelsus Medical University Salzburg, Department of Radiology, Salzburg (Austria); Hirslanden Clinic St. Anna, Clinical Research Group, Lucerne (Switzerland); Froehlich, Johannes M. [Hirslanden Clinic St. Anna, Clinical Research Group, Lucerne (Switzerland); ETH Zurich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Zurich (Switzerland); Cantonal Hospital Winterthur, Department of Radiology, Winterthur (Switzerland); Breitenstein, Stefan [Cantonal Hospital Winterthur, Department of Surgery, Clinic for Visceral and Thoracic Surgery, Winterthur (Switzerland); Doert, Aleksis [Cantonal Hospital Winterthur, Department of Radiology, Winterthur (Switzerland); Pozdniakova, Viktoria [Stavanger University Hospital, Department of Radiology, Stavanger (Norway); Koh, Dow-Mu [Royal Marsden Hospital, Department of Radiology, Surrey, England (United Kingdom); Gutzeit, Andreas [Paracelsus Medical University Salzburg, Department of Radiology, Salzburg (Austria); Hirslanden Clinic St. Anna, Clinical Research Group, Lucerne (Switzerland); Cantonal Hospital Winterthur, Department of Radiology, Winterthur (Switzerland)

    2016-06-15

    To identify correlations of signal enhancements (SE) and SE normalized to reference tissues of the spleen, kidney, liver, musculus erector spinae (MES) and ductus hepatocholedochus (DHC) on hepatobiliary phase gadoxetate-enhanced MRI with patient age in non-cirrhotic patients. A heterogeneous cohort of 131 patients with different clinical backgrounds underwent a standardized 3.0-T gadoxetate-enhanced liver MRI between November 2008 and June 2013. After exclusion of cirrhotic patients, a cohort of 75 patients with no diagnosed diffuse liver disease was selected. The ratio of signal intensity 20 min post- to pre-contrast administration (SE) in the spleen, kidney, liver, MES and DHC, and the SE of the kidney, liver and DHC normalized to the reference tissues spleen or MES were compared to patient age. Patient age was inversely correlated with the liver SE normalized to the spleen and MES SE (both p < 0.001) and proportionally with the SE of the spleen (p = 0.043), the MES (p = 0.030) and the kidney (p = 0.022). No significant correlations were observed for the DHC (p = 0.347) and liver SE (p = 0.606). The age dependence of hepatic SE normalized to the enhancement in the spleen and MES calls for a cautious interpretation of these quantification methods. (orig.)

  20. Transcriptomic analysis of global changes in cytokine expression in mouse spleens following acute Toxoplasma gondii infection.

    He, Jun-Jun; Ma, Jun; Song, Hui-Qun; Zhou, Dong-Hui; Wang, Jin-Lei; Huang, Si-Yang; Zhu, Xing-Quan

    2016-02-01

    Toxoplasma gondii is a global pathogen that infects a wide range of animals and humans. During T. gondii infection, the spleen plays an important role in coordinating the adaptive and innate immune responses. However, there is little information regarding the changes in global gene expression within the spleen following T. gondii infection. To address this gap in knowledge, we examined the transcriptome of the mouse spleen following T. gondii infection. We observed differential expression of 2310 transcripts under these conditions. Analysis of KEGG and GO enrichment indicated that T. gondii alters multiple immune signaling cascades. Most of differentially expressed GO terms and pathways were downregulated, while immune-related GO terms and pathways were upregulated with response to T. gondii infection in mouse spleen. Most cytokines were upregulated in infected spleens, and all differentially expressed chemokines were upregulated which enhanced the immune cells chemotaxis to promote recruitment of immune cells, such as neutrophils, eosinophils, monocytes, dendritic cells, macrophages, NK cells, basophils, B cells, and T cells. Although IFN-γ-induced IDO (Ido1) was upregulated in the present study, it may not contribute a lot to the control of T. gondii because most differentially expressed genes involved in tryptophan metabolism pathway were downregulated. Innate immunity pathways, including cytosolic nucleic acid sensing pathway and C-type lectins-Syk-Card9 signaling pathways, were upregulated. We believe our study is the first comprehensive attempt to define the host transcriptional response to T. gondii infection in the mouse spleen. PMID:26508008

  1. Spleen Stiffness Correlates with the Presence of Ascites but Not Esophageal Varices in Chronic Hepatitis C Patients

    Kazuyo Mori

    2013-01-01

    Full Text Available Although spleen stiffness has recently been identified as potential surrogate marker for portal hypertension, the relationship between spleen stiffness and portal hypertension has not been fully elucidated. We attempted to determine the relationship between the liver or spleen stiffness and the presence of ascites or esophageal varices by acoustic radiation force impulse (ARFI imaging. A total of 33 chronic hepatitis C (CHC patients (median age 68; range 51–84 were enrolled. We evaluated the relationship between the liver or spleen stiffness and indicators of portal hypertension as well as clinical and biochemical parameters. Fourteen healthy volunteers were used for validating the accuracy of AFRI imaging. The liver and spleen stiffness increased significantly with progression of liver disease. A significant positive correlation was observed between the liver and spleen stiffness. However, spleen stiffness, but not liver stiffness, was significantly associated with the presence of ascites (, while there was no significant association between the spleen stiffness and spleen index/presence of esophageal varices in CHC patients. The area under the receiver operating characteristic curve based on the spleen stiffness was 0.80. In conclusion, spleen stiffness significantly correlates with the presence of ascites but not esophageal varices in CHC patients.

  2. An exploration study to find important factors influencing on brand in car accessory market

    Naser Azad

    2013-08-01

    Full Text Available Supplying car accessory is one of the most important growing industries in the world. Every year, millions of cars are produced and people need to have the access to necessary car accessory. In this paper, we present an exploration study to detect important factors influencing car accessory market. The proposed study designs a questionnaire in Likert scale consists of 16 questions, distributes it among 200 experts and analyses it using factor analysis. Cronbach alpha and Kaiser-Meyer-Olkin Measure of Sampling Adequacy are calculated as 0.823 and 0.863, which validate the overall questionnaire. The results indicate that there are three influencing factors including brand capability, brand characteristics and consumers’ believe.

  3. Male breast cancer originating in an accessory mammary gland in the axilla: a case report.

    Yamamura, Jun; Masuda, Norikazu; Kodama, Yoshinori; Yasojima, Hiroyuki; Mizutani, Makiko; Kuriyama, Keiko; Mano, Masayuki; Nakamori, Shoji; Sekimoto, Mitsugu

    2012-01-01

    Carcinoma of an accessory mammary gland is an extremely rare tumor. A 61-year-old male patient presented with a hard mass measuring 85 mm × 51 mm in the left axilla. Incisional biopsy histopathologically showed an adenocarcinoma compatible with breast carcinoma originating in an accessory mammary gland. Systemic examinations revealed no evidence of malignant or occult primary lesion in the bilateral mammary glands or in other organs. Neoadjuvant chemotherapy was performed for the locally advanced axillary tumor and reduced the tumor to 55 mm in size, and, then, he could undergo complete resection with a negative surgical margin in combination with reconstructive surgery to fill the resulting skin defect with a local flap of the latissimus dorsi muscle. The patient has presented with no metastatic lesion in four years since the operation. This unusual case shows that neoadjuvant chemotherapy is an effective and tolerated therapy for advanced accessory breast cancer in the axilla. PMID:23251170

  4. CASE REPORT: A RARE CASE OF ACCESSORY NIPPLE (POLYTHELIA PRESENTING AS PAPILLARY ADENOMA

    Shekappa C

    2014-02-01

    Full Text Available Nipple adenoma is a relatively rare benign breast neoplasm, and cases of the disease arising from the Accessory breast nipple are a rare entity. We report a case of nipple adenoma arising from accessory nipple. A 24 - year - old woman presented with the complaint of pain and bleeding from accessory nipple since 4 months in right breast. Physical examination confirmed a well - defined nipp le in the milk line 5 cm below right nipple. The diagnosis of nipple adenoma was made from an excisional specimen on the basis of characteristic histological findings. Because clinically nipple adenoma may resemble Paget’s disease and pathologically can be misinterpreted as tubular carcinoma, the correct identification of nipple adenoma is an important factor in the differential diagnosis for nipple neoplasms

  5. Relative contribution of expectancy and immediate arousal to the facilitatory effect of an auditory accessory stimulus

    F. Del-Fava

    2004-08-01

    Full Text Available An auditory stimulus speeds up a digital response to a subsequent visual stimulus. This facilitatory effect has been related to the expectancy and the immediate arousal that would be caused by the accessory stimulus. The present study examined the relative contribution of these two influences. In a first and a third experiment a simple reaction time task was used. In a second and fourth experiment a go/no-go reaction time task was used. In each of these experiments, the accessory stimulus preceded the target stimulus by 200 ms for one group of male and female volunteers (G Fix. For another group of similar volunteers (G Var the accessory stimulus preceded the target stimulus by 200 ms in 25% of the trials, by 1000 ms in 25% of the trials and was not followed by the target stimulus in 50% of the trials (Experiments 1a and 1b or preceded the target stimulus by 200 ms in 6% of the trials and by 1000 ms in 94% of the trials (Experiments 2a and 2b. There was a facilitatory effect of the accessory stimulus for G Fix in the four experiments. There was also a facilitatory effect of the accessory stimulus at the 200-ms stimulus onset asynchrony for G Var in Experiments 1a and 1b but not in Experiments 2a and 2b. The facilitatory effects observed were larger in the go/no-go task than in the simple task. Taken together, these results suggest that expectancy is much more important than immediate arousal for the improvement of performance caused by an accessory stimulus.

  6. Accessory left atrial diverticulae: contractile properties depicted with 64-slice cine-cardiac CT.

    Killeen, Ronan P

    2012-02-01

    To assess the contractility of accessory left atrial appendages (LAAs) using multiphasic cardiac CT. We retrospectively analyzed the presence, location, size and contractile properties of accessory LAAs using multiphasic cardiac 64-slice CT in 102 consecutive patients (63 males, 39 females, mean age 57). Multiplanar reformats were used to create image planes in axial oblique, sagittal oblique and coronal oblique planes. For all appendages with an orifice diameter >or= 10 mm, axial and sagittal diameters and appendage volumes were recorded in atrial diastole and systole. Regression analysis was performed to assess which imaging appearances best predicted accessory appendage contractility. Twenty-three (23%) patients demonstrated an accessory LAA, all identified along the anterior LA wall. Dimensions for axial oblique (AOD) and sagittal oblique (SOD) diameters and sagittal oblique length (SOL) were 6.3-19, 3.4-20 and 5-21 mm, respectively. All appendages (>or=10 mm) demonstrated significant contraction during atrial systole (greatest diameter reduction was AOD [3.8 mm, 27%]). Significant correlations were noted between AOD-contraction and AOD (R = 0.57, P < 0.05) and SOD-contraction and AOD, SOD and SOL (R = 0.6, P < 0.05). Mean diverticulum volume in atrial diastole was 468.4 +\\/- 493 mm(3) and in systole was 171.2 +\\/- 122 mm(3), indicating a mean change in volume of 297.2 +\\/- 390 mm(3), P < 0.0001. Stepwise multiple regression analysis revealed SOL to be the strongest independent predictor of appendage contractility (R(2) = 0.86, P < 0.0001) followed by SOD (R(2) = 0.91, P < 0.0001). Accessory LAAs show significant contractile properties on cardiac CT. Those accessory LAAs with a large sagittal height or depth should be evaluated for contractile properties, and if present should be examined for ectopic activity during electrophysiological studies.

  7. Accessory lobe of the right liver mocking a pulmonary tumor in an adult woman.

    Kitamura, Yuka; Sakakura, Noriaki; Uchida, Tatsuo; Suyama, Motokazu

    2012-08-01

    We report a rare case of an accessory lobe of the liver in the right thoracic cavity with the past history of breast cancer. A 66-year-old woman underwent thoracotomy owing to a slowly growing suspected lung tumor identified by computed tomography. The intraoperative findings revealed an accessory lobe of the liver. If this possibility had been considered, the correct diagnosis could have been achieved using computed tomography with multi-directional scanning, so that an unnecessary operation could have been avoided. PMID:22618988

  8. Imaging diagnosis of accessory and cavitated uterine mass, a rare mullerian anomaly

    Nishchint Jain

    2014-01-01

    Full Text Available Accessory and Cavitated Uterine Mass (ACUM is a rare form of developmental Mullerian anomaly seen in young females, which presents as chronic recurrent pelvic pain and severe dysmenorrhea. It is an accessory cavity lying within an otherwise normal uterus. It is lined by functional endometrium and surrounded by myometrium-like smooth muscle cells; hence, it bears striking macroscopic and microscopic resemblance to the uterus. Hysterosalpingography (HSG, Ultrasonography (USG, and Magnetic Resonance Imaging (MRI form the mainstay of diagnostic imaging. The entity is often under diagnosed; therefore, a high index of suspicion combined with HSG and MRI imaging can help in making an accurate diagnosis.

  9. 15 CFR 742.11 - Specially designed implements of torture, thumbscrews, and thumbcuffs; and parts and accessories...

    2010-01-01

    ... torture, thumbscrews, and thumbcuffs; and parts and accessories, n.e.s. 742.11 Section 742.11 Commerce and....11 Specially designed implements of torture, thumbscrews, and thumbcuffs; and parts and accessories... cooperation from like-minded countries in maintaining controls on implements of torture, at this time...

  10. 26 CFR 48.4061(a)-4 - Parts or accessories sold on or in connection with chasis, bodies, etc.

    2010-04-01

    ... 26 Internal Revenue 16 2010-04-01 2010-04-01 true Parts or accessories sold on or in connection with chasis, bodies, etc. 48.4061(a)-4 Section 48.4061(a)-4 Internal Revenue INTERNAL REVENUE SERVICE... Parts or accessories sold on or in connection with chasis, bodies, etc. (a) In general. The tax...

  11. Estimation of the volume and percent uptake of the liver and spleen by SPECT

    The volume and percent uptake of the liver and spleen were estimated with single photon emission computed tomography (SPECT) using 99mTc-phytate. Clinical usefulness of these parameters was evaluated by comparison with other liver function tests in 87 patients including 25 normal controls, 24 liver cirrhosis and 16 other chronic liver diseases. SPECT images were obtained by Maxi Camera 400T. Cut-off level for reconstruction of images and relationship between counts and activity (mCi) were obtained from phantom studies. Volumes estimated using SPECT and computed tomography were compared in 16 patients. Results obtained were as follows. 1) Optimal cut-off level for measurement of volumes for the liver was 37 % and for the spleen was 42 %. 2) Correlation between organ volumes estimated with CT and SPECT was good (r = 0.92 for the liver and r = 0.96 for the spleen), although volumes measured with SPECT were larger than those with CT. 3) Significant differences of percent uptake were observed between normal controls and liver cirrhosis. 4) Better correlation between spleen volumes and uptake was recognized in cases without liver cirrhosis than in cases with liver cirrhosis. The spleen uptake in liver cirrhosis was higher than those in others in comparison with the volume. 5) The liver/spleen ratio of 99mTc-phytae uptake could most clearly differentiate liver cirrhosis from others. 6) Negative correlation was observed between liver volume or uptake and ICG (R15). Estimation of volume and uptake of the liver and spleen could be a useful procedure to assess liver function, probably related with effective hepatic blood flow in liver cirrhosis. (author)

  12. MICROSCOPIC STRUCTURE AND MORPHOMETRIC PARAMETERS OF EUROPEAN CATFISH (SILURIS GLANIS L. SPLEEN

    O. Dunaevskaya

    2016-03-01

    Full Text Available Purpose. Study of the microscopic structure and morphometric parameters of European catfish spleen. Methodology. For the study, we used the spleen of clinically healthy age-2 European catfish (Silurus glanis L.. We determined the absolute and relative weight of the organ or the index of spleen development. For the histological studies, pieces of the material were preserved in 10-12 % cooled neutral formalin solution, with subsequent filling in paraffin. Paraffin sections were prepared using a sledge microtome, with a thickness of no more than 10 microns. To determine the cell and tissue morphology under light microscopy, we the staining of histological sections with hematoxylin and eosin. Determination of spleen linear dimensions, morphometric measurements were carried out using the "Master of Morphology". Quantitative parameters were analyzed in "Statistica 6.0". Findings. European catfish spleen corresponded to general regularities of fish spleen structure: we identified support-contractile apparatus, white and red pulp and inherent cellular composition. Peculiarities of the microscopic structure of this organ in European catfish is underdevelopment of radial trabeculae, poor development of periarterial lymphoid sheaths, absence of the differentiation to zones in lymphoid nodules. The most developed was red pulp (70.82 ± 10.76%, the least developed — support-contractile apparatus (7.04 ± 0.65%. The base of the white pulp (22.14 ± 6.61% is lymphoid nodules without propagation center. The support-contractile apparatus of the spleen, which includes capsule and trabecular system, is developed unevenly. E.g., the capsule thickness in different parts of the body is not the same, the biggest thickness is in porta, where it attains 21.85 ± 7.44 micrometers, its relative area is 3.06 ± 0.32%. Relative area of the trabecular system is 3.98 ± 2.57%, the most developed are vascular trabeculae. Originality. We found the peculiarities of spleen

  13. Acute cadmium administration to rats exerts both immunosuppressive and proinflammatory effects in spleen

    Highlights: • The effect of cadmium on splenic T and innate immune cells in rats is explored. • Differential effects of 1 mg/kg on T cell and innate immune activities were shown. • Lower Cd dose (0.5 mg/kg) cause less pronounced immunosuppressive effects. • Proinflammatory effects on innate immune activities were seen at that dose. • Presented data depict complexity of immunomodulatory potential of this metal. - Abstract: Conflicting data (both suppression and augmentation as well as lack of the effect) exist in respect to cadmium (Cd) and splenic T cell-based immune cell activity. Spleen is also the site of innate immune responses but impact of Cd on this type of immunity has been less explored. In the present study the effects of acute Cd administration on basic aspects of both T cell-based and innate immune spleen cell activity were examined in rats. Intraperitoneal injection of 1 mg of Cd/kg resulted in decrease in concanavalin A (ConA) induced proliferation which seems to be more related to altered spleen cells responsiveness to IL-2 than to apoptosis. Differential effects on proinflammatory T cell derived cytokines were observed (decreases of IFN-γ gene expression and ConA-stimulated production, but increases in IL-17 mRNA levels with no effect on concentrations of protein product). Reduction of IFN-γ production seemed not to rely on IL-4 and IL-10, but at least partly on nitric oxide (NO). Increased activity relevant for innate immunity (granulocyte and CD11b+ cell accumulation in the spleen, inducible nitric oxide synthase/iNOS expression and NO production by spleen cells) was observed, but there was a decrease in respiratory burst (dihydrorhodamine/DHR oxidation and nitroblue tetrazolium/NBT reduction). Increases of TNF-α and IL-1β gene expression and IL-1β protein product were noted as well. Administration of 0.5 mg Cd/kg resulted in less pronounced (ConA-induced proliferation) or lack of the effect (IFN-γ production) on spleen T cell

  14. Haemopoiesis in murine bone marrow and spleen after fractionated irradiation and repeated bone marrow transplantation. I

    Erythropoiesis was studied in mice repeatedly exposed to doses of 3 Gy of 60Co γ-rays at 4-day intervals up to a total dose of 24 Gy on the basis of total bone marrow and spleen cellularity follow-up and analysis of myelograms and splenograms. Half the number of the mice received 106 nuclear cells of syngeneic bone marrow after each fractional radiation dose. It was mainly the spleen which was involved in the adaptation and regeneration of erythropoiesis, its contribution to total erythropoiesis in bone marrow recipients having been as high as 73.9% (day 20 of experiment, total dose 15 Gy). In mice only irradiated, the number of nuclear cells of erythroid lineage decreased to zero values sooner in the spleen (day 16 of experiment, total dose 12 Gy) than in the bone marrow (day 24 of experiment, total dose 18 Gy). The analysis of the results of collections made on day 9 after the last irradiation revealed, however, that the hemopoietic microenvironment of the spleen and hemopoietic cells capable of differentiation in the erythroid direction were so resistant to irradiation in mice only irradiated that erythropoiesis in their spleens exhibited signs of regeneration even after the highest total dose of 24 Gy. (author). 2 figs., 3 tabs., 12 refs

  15. CENTRAL NERVOUS REGULATION OF SPLEEN FUNCTION: NEW INSIGHTS FROM ANIMAL STUDIES

    Manoj G Tyagi

    2012-05-01

    Full Text Available The spleen is located in the upper left quadrant of the abdomen. It has two main functions that is acting as part of the immune system and as a filter. The spleen has a thin connective tissue capsule from which short septa extend inwards. These septa are, in turn, connected to a complex reticulin framework.There are two distinct components of the spleen, the red pulp and the white pulp. The red pulp consists of large numbers of sinuses and sinusoids filled with blood and is responsible for the filtration function of the spleen. The splenic venomotor fibres join the left phrenic nerve in the mid-cervical region. Coursing with it as non-medullated fibres, they eventually perforate the diaphragm, where for a time they accompany the inferior phrenic artery. Deviating towards the celiac ganglion, they next join company with the splenic vein, and are eventually distributed to localised parts of the vein. This review article evaluates the conventional knowledge and points to new insights into neural regulation of spleen.

  16. Impaired spleen structure and chemokine expression in ME7 scrapie-infected mice.

    Kim, Soochan; Han, Sinsuk; Lee, Hyung Soo; Kim, Yong-Sun; Choi, Eun-Kyoung; Kim, Mi-Yeon

    2016-08-01

    We have previously demonstrated that prion protein-deficient (Prnp(0/0)) Zürich I mice display impaired T zone structure resulting from decreased splenic expression of the T cell homing chemokines, CCL19 and CCL21. Prions are transported to, and colonise in, the secondary lymphoid tissues. Therefore, in order to investigate how scrapie infection affects the splenic white pulp structure, we infected C57BL/6 mice with the mouse-adapted scrapie strain ME7 and analysed end-stage prion disease. We found that the white pulp regions of ME7-infected spleens were smaller, and contained markedly diminished T zones, as compared to control spleens. Although lymphoid tissue inducer cells were not affected, the expression of both CCL19 and CCL21 was decreased. In addition, the networks of follicular dendritic cells, which are known to express high levels of the cellular prion protein (PrP(C)) and to accumulate PrP(Sc) following scrapie infection, were larger in ME7-infected spleens. Further, they were associated with increased numbers of B cells expressing high levels of IgM. These data indicate that ME7-infected spleens display phenotype characteristics different from those reported for Prnp(0/0) spleens mainly due to the gain of PrP(Sc) function and suggest that the PrP(C) is required, not only to form the splenic white pulp structure, but also to maintain the intact T zone structure. PMID:27021907

  17. Treating insomnia from spleen and stomach%从脾胃辨治不寐

    杨玉柯

    2012-01-01

      Stomach function disorders can cause insomnia, variety of symptoms of Shizhi Yongzu, movements disorders;overwork spleen injury, lack of effort;spleen loss of transportation metaplasia phlegm. Treatment should be based on the Xiaodao Hewei;Spleen Qi, nourishing the nerves;spleen to help transport qi and phlegm method to restore the function of the spleen and stomach, sleep soundly at night of course just fine, and to focus on treatment seeking nature.%  脾胃功能失调均能引起不寐,其中各症分别为食滞壅阻,升降失调;过劳伤脾,心血不足;脾虚失运,化生痰湿。治疗以消导和胃,调畅气机;益气补脾,养血安神;健脾助运,行气化痰;为方法,恢复脾胃功能,则夜寐自安,并要注重治病求本。

  18. Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses.

    Demenesku, Jelena; Popov Aleksandrov, Aleksandra; Mirkov, Ivana; Ninkov, Marina; Zolotarevski, Lidija; Kataranovski, Dragan; Brceski, Ilija; Kataranovski, Milena

    2016-08-10

    The impact of genetic background on effects of acute i.p. cadmium administration (0.5mg/kg and 1mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell's proliferative ability) in DA rats at 1mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-γ)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b(+) cells to lungs of DA rats treated with 1mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this metal. However, lack of strain disparity in lung cells IFN-γ responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity. PMID:27234498

  19. Factors influencing liver and spleen volume changes after donor hepatectomy for living donor liver transplantation

    To define the changes in liver and spleen volumes in the early postoperative period after partial liver donation for living-donor liver transplantation (LDLT) and to determine factors that influence liver and spleen volume changes. 27 donors who underwent partial hepatectomy for LDLT were included in this study. The rates of liver and spleen volume change, measured with CT volumetry, were correlated with several factors. The analyzed factors included the indocyanine green (ICG) retention rate at 15 minutes after ICG administration, preoperative platelet count, preoperative liver and splenic volumes, resected liver volume, resected-to-whole liver volume ratio (LVR/LVW), resected liver volume to the sum of whole liver and spleen volume ratio [LVR/(LVW + SV0)], and pre and post hepatectomy portal venous pressures. In all hepatectomy donors, the volumes of the remnant liver and spleen were increased (increased rates, 59.5 ± 50.5%, 47.9 ± 22.6%). The increment rate of the remnant liver volume revealed a positive correlation with LVR/LVW (r = 0.759, p R/LVW influences the increment rate of the remnant liver volume.

  20. Anisotropic microstructured poly(vinyl alcohol) tissue-mimicking phantoms.

    Dawson, Andrew; Harris, Paul; Gouws, Gideon

    2010-07-01

    Novel microstructured PVA phantoms mimicking fibrous tissues have been developed using a simple freeze-casting process. Scanning electron micrographs reveal highly anisotropic microstructure with dimensions of the order of 5 to 100 microm. Characterization of an example phantom revealed acoustic properties consistent with those found in fibrous tissues. At 20 MHz, the velocity measured parallel to the microstructure orientation of 1555 ms(-1) was significantly greater than that perpendicular to the microstructure of 1537 ms(-1). The attenuation coefficient was measured to be 5 dBxmm(-1) and proportional to the 1.6 power of frequency, which is in good agreement with that for normal human myocardium. PMID:20639144

  1. Xanthogranulomatous Appendicitis Mimicking Residual Burkitt's Lymphoma After Chemotherapy

    Nam, Soomin; Choi, Sung-Eun; Kim, Yu Ri; Baik, Seung Hyuk; Sohn, Seung-Kook

    2016-01-01

    The case of a 23-year-old female treated with aggressive high-dose therapy for Burkitt's lymphoma is reported. A positron emission tomography and computed tomography scan after completion of chemotherapy revealed a residual hypermetabolic lesion in the right pelvic cavity. A pelvic magnetic resonance imaging scan showed circumferential wall thickening at the tip of the appendix. A laparoscopic exploration and appendectomy were performed, and a pathologic examination of the resected appendix revealed xanthogranulomatous appendicitis. This is a rare case of a xanthogranulomatous appendicitis mimicking remnant Burkitt's lymphoma after completion of chemotherapy.

  2. Giant Ectopic Ureter Mimicking Pelvic Organ Prolapse: A Case Report

    Adnan Simsir; Fuat Kizilay; Bilbasar Yildiz; Oktay Nazli

    2011-01-01

    Ectopic ureter is one of the most common urinary tract anomalies. We, herein, present a case of a giant ureter with ectopic orifice, mimicking pelvic organ prolapse, which is the first in the literature. A 59-year-old female patient presenting with frequently recurrent urinary tract infection had grade 3 pelvic organ prolapse. On examination, the organ producing the appearance of prolapse was found to be a right ureter of giant size and was obstructed by a large stone at the distal segment. T...

  3. Primary hepatic tuberculosis mimicking intrahepatic cholangiocarcinoma: report of two cases

    2015-01-01

    Hepatic tuberculosis (TB) is usually associated with pulmonary or miliary TB, but primary hepatic TB is very uncommon even in countries with high prevalence of TB. The clinical manifestation of primary hepatic TB is atypical and imaging modalities are unhelpful for differential diagnosis of the liver mass. Image-guided needle biopsy is the best diagnostic method for primary hepatic TB. In the cases presented here, we did not perform liver biopsy because we believed the liver masses were cholangiocarcinoma, but primary hepatic TB was ultimately confirmed by postoperative pathology. Here we report two cases of patients who were diagnosed with primary hepatic TB mimicking mass-forming intrahepatic cholangiocarcinoma. PMID:26236700

  4. A CUTANEOUS HORN MIMICKING POLYDACTYLY: A CASE REPORT

    Funda Tamer

    2015-04-01

    Full Text Available A cutaneous horn is a general name for cornified material protruding from skin. On the other hand, polydactyly is a common congenital anomaly of the hand and foot which is characterized by extra finger or toe. A cutaneous horn might mimick polydactyly by resembling an extra toe. Hereby, we present a 72-year-old white Caucasian male with an extra toe-like projection on his fourth toe. Initially, polydactyly was suspected, however a cutaneous horn was also considered. The lesion was surgically removed. The histopathological examination of the specimen revealed hyperkeratosis, and thus confirmed the  lesion to be a cutaneous horn. 

  5. Xanthogranulomatous Appendicitis Mimicking Residual Burkitt's Lymphoma After Chemotherapy.

    Nam, Soomin; Kang, Jeonghyun; Choi, Sung-Eun; Kim, Yu Ri; Baik, Seung Hyuk; Sohn, Seung-Kook

    2016-04-01

    The case of a 23-year-old female treated with aggressive high-dose therapy for Burkitt's lymphoma is reported. A positron emission tomography and computed tomography scan after completion of chemotherapy revealed a residual hypermetabolic lesion in the right pelvic cavity. A pelvic magnetic resonance imaging scan showed circumferential wall thickening at the tip of the appendix. A laparoscopic exploration and appendectomy were performed, and a pathologic examination of the resected appendix revealed xanthogranulomatous appendicitis. This is a rare case of a xanthogranulomatous appendicitis mimicking remnant Burkitt's lymphoma after completion of chemotherapy. PMID:27218100

  6. Epithelioid sarcoma mimicking abscess: review of the MRI appearances

    A case of epithelioid sarcoma involving the soft tissue of the ankle is presented. The tumor was a hemorrhagic, fluid-filled, multiloculated lesion with inflammatory changes in the surrounding planes. Tuberculous abscess was diagnosed on the basis of the clinical picture, ultrasound and MRI findings. Surgical exploration of the ankle mass was carried out because of lack of local healing while the patient's general and pulmonary status improved on antituberculosis treatment. This was an unusual case of epithelioid sarcoma mimicking a multilocular abscess. (orig.)

  7. Unusual Case of Overt Aortic Dissection Mimicking Aortic Intramural Hematoma.

    Disha, Kushtrim; Kuntze, Thomas; Girdauskas, Evaldas

    2016-04-01

    We report an interesting case in which overt aortic dissection mimicked two episodes of aortic intramural hematoma (IMH) (Stanford A, DeBakey I). This took place over the course of four days and had a major influence on the surgical treatment strategy. The first episode of IMH regressed completely within 15 hours after it was clinically diagnosed and verified using imaging techniques. The recurrence of IMH was detected three days thereafter, resulting in an urgent surgical intervention. Overt aortic dissection with evidence of an intimal tear was diagnosed intraoperatively. PMID:27066437

  8. Bulky mediastinal aspergillosis mimicking cancer in an immunocompetent patient.

    Stern, Jean-Baptiste; Wyplosz, Benjamin; Validire, Pierre; Angoulvant, Adela; Fregeville, Aude; Caliandro, Raffaele; Gossot, Dominique

    2014-10-01

    We describe the case of a previously healthy 42-year-old woman who presented with a chronic cough and occasional night sweats. Radiologic exploration showed a bulky mediastinal mass surrounding the aortic arch, associated with a left subclavicular lymph node and a cerebral round lesion, mimicking a disseminated lung cancer. Surgical left subclavicular and computed tomography-guided mediastinal biopsy specimens showed granulomatous patterns. Mycologic culture of both samples grew Aspergillus flavus. Resolution was obtained after 9 months of oral voriconazole therapy. PMID:25282220

  9. A huge renal capsular leiomyoma mimicking retroperitoneal sarcoma

    Lal Anupam

    2009-01-01

    Full Text Available A huge left renal capsular leiomyoma mimicking retroperitoneal sarcoma presented in a patient as an abdominal mass. Computed tomography displayed a large heterogeneous retro-peritoneal mass in the left side of the abdomen with inferior and medial displacement as well as loss of fat plane with the left kidney. Surgical exploration revealed a capsulated mass that was tightly adherent to the left kidney; therefore, total tumor resection with radical left nephrectomy was performed. Histopathology ultimately confirmed the benign nature of the mass. This is the largest leiomyoma reported in literature to the best of our knowledge.

  10. An Adult Gastric Duplication Cyst Mimicking a Gastrointestinal Stromal Tumor.

    Yoda, Takenori; Furihata, Makoto; Nagao, Sayaka; Wada, Tomonori

    2016-01-01

    We herein describe a rare case of a 24-year-old man who presented with severe epigastralgia after consuming a considerable amount of broiled meat. Computed tomography revealed a cystic lesion adjacent to the distal stomach, with high intensity on T2-weighted magnetic resonance imaging. Upper endoscopy showed a cystic mass measuring 6 cm in diameter, mimicking a submucosal tumor adjacent to the pyloric valve, with duodenum invagination, characteristic of ball valve syndrome. Endoscopic ultrasonography showed that the lesion was contiguous through the first to the third layer of the stomach. Therefore, we performed distal gastrectomy. Pathology showed that the lesion was a gastric duplication cyst without malignancy. PMID:27580540

  11. Subcutaneous Phaeohyphomycosis Due to Pyrenochaeta romeroi Mimicking a Synovial Cyst

    Dinh, Aurélien; Levy, Bruno; Bouchand, Frédérique; Davido, Benjamin; Duran, Clara; Cristi, Marin; Felter, Adrien; Salomon, Jérôme; Ait Ammar, Nawel

    2016-01-01

    Opportunistic subcutaneous fungal infections are increasing nowadays due to the growing number of medical conditions causing immunosuppression, especially organ transplant. The incidence rate of subcutaneous phaeohyphomycosis is very low. Most studies found are case reports. They showed a wide variation of clinical presentations. Pyrenochaeta romeroi, a fungus from the Dematiaceae group is a saprophyte found in soil and plants and a possible causative agent of phaeohyphomycosis. We present a rare case of subcutaneous phaeohyphomycosis caused by P. romeroi mimicking a synovial cyst in a diabetic patient.

  12. Exophytic Atheroma Mimicking Papillary Fibroelastoma Adjacent to the Aortic Valve.

    Cho, Tomoki; Tokunaga, Shigehiko; Yasuda, Shota; Izubuchi, Ryo; Masuda, Munetaka

    2015-09-01

    Follow-up echocardiography in a 69-year-old man with alcoholic cardiomyopathy showed a mass above the aortic valve near the left coronary ostium. Transesophageal echocardiography and computed tomography suggested a papillary fibroelastoma with a high risk of embolism. At operation we found an exophytic atheroma adjacent to the left coronary artery orifice. The atheroma was removed, and the patient made an uneventful recovery. We describe this very rare case of an exophytic atheroma mimicking a papillary fibroelastoma situated at the left coronary orifice. PMID:26354633

  13. Hızma Induced Papul of Nose Mimicking Pyogenic Granuloma

    Mualla Polat

    2014-09-01

    Full Text Available The application of body piercing is popular among young people, who consider it as a sign of marginality, beauty, or group identity. Piercing procedure is observed to cause a large number of complications such as infections, pain, inflammatory reactions, bleeding, dental fractures or fissures, and gingival damage, etc., mostly in young individuals. Hizma is a traditional body ornament worn by Anatolian women via a piercing procedure. Herein, we describe a papule of nose mimicking pyogenic granuloma as an uncommon complication of Hızma.

  14. Normal and accessory fissures of the lung: Evaluation with contiguous volumetric thin-section multidetector CT

    The purpose of this study was to use volumetric, 1.25 mm collimation MDCT read as softcopy and using a 2D and 3D viewer tool, to establish the frequency of normal and accessory fissures, the continuity of the fissures, whether the fissures are visible as a thin line, a hypovascular region, or both, and also to establish the interobserver agreement of readers. 150 consecutive MDCT examinations were retrospectively assessed. Interobserver agreement for each of these fissures was evaluated using the Kappa statistic. All subjects had a right and a left major fissure. 96.7% of subjects also had a right minor fissure. 40% had an accessory fissure, the most common, the left minor in 16% of subjects. Most of the three usual fissures were continuous, whereas fewer than half of accessory fissures were continuous. The majority (54-100%) of normal and accessory fissures were visualized as a thin line. There was substantial to excellent interobserver agreement on the presence or absence of fissures their continuity (k = 0.96), and fair to excellent agreement on fissure morphology (k = 0.37-1.0). The prevalence of fissures on MDCT, equivalent to autopsy studies, visualizing fissures as a thin line and high interobserver agreement is probably due to the high sensitivity of MDCT, secondary to thin-section volumetric imaging.

  15. 26 CFR 48.4061(b)-2 - Definition of parts or accessories.

    2010-04-01

    ... motors, and other automobile parts or accessories. (c) Materials of a general use—(1) General rule. The term “parts or accessories” also does not include material such as glass, cloth, leather, matting linoleum, and other materials sold in rolls or by the foot, such as brake lining, tape, binding,...

  16. Dissociation between Anterograde and Retrograde Conduction during Transvenous Cryoablation of Parahissian Accessory Pathways

    Sorgente, A.; Paparella, G.; Chierchia, G.B.; Sarkozy, A.; Asmundis, C. de; Muller-Burri, S.A.; Yazaki, Y.; Capulzini, L.; Brugada, P.

    2011-01-01

    Ablation of parahissian accessory pathways (APs) is a challenging procedure because of the high risk to provoke "iatrogenic" atrioventricular (AV) nodal block. The feasibility and safety of cryoablation (CA) have been already demonstrated both in patients with AV nodal reentry tachycardia and in tho

  17. Giant accessory breast: a rare occurrence reported, with a review of the literature.

    Hiremath, Bharati; Subramaniam, Narayana; Chandrashekhar, Nayan

    2015-01-01

    Polymastia, or the presence of supranumerary breasts, occurs in 2-6% of the female population, the spectrum of the disorder ranging between a small mole and a fully functional ectopic breast. They are often asymptomatic but require treatment when symptomatic or if they harbour malignancy. We present a case of a 41-year-old woman with an accessory breast in the left inframammary fold, which increased in size over the decade following her first pregnancy, to reach a size almost three times that of her right breast. Preoperative fine-needle aspiration and ultrasound was suggestive of accessory breast tissue, distinct from the left breast. Intraoperatively, a 14×10×8 cm accessory breast was found in the inframammary fold, distinct from the left breast and having an accessory nipple areola complex as well. A simple mastectomy was performed with trimming and rotation of the inframammary flap. The patient was happy with the cosmetic outcome. This article also reviews the literature and covers classification of polymastia, diagnostic complexities and challenges associated with surgery. PMID:26542818

  18. 29 CFR 1919.28 - Unit proof tests-cranes and gear accessory thereto.

    2010-07-01

    ... Section 1919.28 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... with gear accessory thereto, shall be tested with a proof load which shall exceed the safe working load as follows: Safe working load Proof load Up to 20 tons 25 percent in excess. 20-50 tons 5 tons...

  19. 21 CFR 878.4820 - Surgical instrument motors and accessories/attachments.

    2010-04-01

    ... HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Surgical Devices § 878... surgical procedures to provide power to operate various accessories or attachments to cut hard tissue or... controls). The device is exempt from the premarket notification procedures in subpart E of part 807 of...

  20. Hyperviscosity of semen in patients with male accessory gland infection:direct measurement with quantitative viscosimeter.

    La Vignera, S; Condorelli, R A; Vicari, E; D'Aagata, R; Salemi, M; Calogero, A E

    2012-05-01

    The aim of this study was to evaluate whether the viscosity of semen in patients with male accessory gland infection is related to the extension of the inflammatory process to the various glands. To achieve this, viscosity was assessed by quantitative viscosimeter and the results were expressed in centipoise (cps). The study was conducted on 30 infertile patients with clinical evidence of male accessory gland infection and a mean age of 29.0 ± 4.0 years. Their semen viscosity was evaluated through quantitative viscometer. All patients showed an increase of viscosity evaluated according to WHO criteria, while this parameter was normal in all controls. Semen viscosity of patients with male accessory gland infection (28.6 ± 2.2 cps) was significantly (P < 0.05) higher than that in the controls (10.7 ± 0.6 cps). Significantly increasing values were observed in patients with involvement of multiple gland inflammation (prostatitis accessory gland infection. PMID:21919943

  1. Surgical treatment of a comminuted articular fracture of the accessory carpal bone in a thoroughbred horse

    The clinical, radiographic and ultrasonographic findings in a case ofa comminuted articular fracture of the accessory carpal bone of a thoroughbred chaser are described, and its surgical treatment and aftercare are detailed. The horse made an uneventful recovery and successfully returned to racing

  2. 21 CFR 876.4730 - Manual gastroenterology-urology surgical instrument and accessories.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Manual gastroenterology-urology surgical... OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Surgical Devices § 876.4730 Manual gastroenterology-urology surgical instrument and accessories. (a)...

  3. Normal and accessory fissures of the lung: Evaluation with contiguous volumetric thin-section multidetector CT

    Cronin, Paul, E-mail: pcronin@med.umich.ed [Department of Radiology, Division of Cardiothoracic Radiology, University of Michigan Medical Center, Ann Arbor, MI (United States); Gross, Barry H.; Kelly, Aine Marie; Patel, Smita; Kazerooni, Ella A. [Department of Radiology, Division of Cardiothoracic Radiology, University of Michigan Medical Center, Ann Arbor, MI (United States); Carlos, Ruth C. [Division of Magnetic Resonance Imaging, University of Michigan Medical Center, Ann Arbor, MI (United States)

    2010-08-15

    The purpose of this study was to use volumetric, 1.25 mm collimation MDCT read as softcopy and using a 2D and 3D viewer tool, to establish the frequency of normal and accessory fissures, the continuity of the fissures, whether the fissures are visible as a thin line, a hypovascular region, or both, and also to establish the interobserver agreement of readers. 150 consecutive MDCT examinations were retrospectively assessed. Interobserver agreement for each of these fissures was evaluated using the Kappa statistic. All subjects had a right and a left major fissure. 96.7% of subjects also had a right minor fissure. 40% had an accessory fissure, the most common, the left minor in 16% of subjects. Most of the three usual fissures were continuous, whereas fewer than half of accessory fissures were continuous. The majority (54-100%) of normal and accessory fissures were visualized as a thin line. There was substantial to excellent interobserver agreement on the presence or absence of fissures their continuity (k = 0.96), and fair to excellent agreement on fissure morphology (k = 0.37-1.0). The prevalence of fissures on MDCT, equivalent to autopsy studies, visualizing fissures as a thin line and high interobserver agreement is probably due to the high sensitivity of MDCT, secondary to thin-section volumetric imaging.

  4. Accessory roots and root canals in human anterior teeth: a review and clinical considerations.

    Ahmed, H M A; Hashem, A A

    2016-08-01

    Anterior teeth may have aberrant anatomical variations in the number of roots and root canals. A review of the literature was conducted using appropriate key words in major endodontic journals to identify the available reported cases as well as experimental and clinical investigations on accessory roots and root canals in anterior teeth. After retrieving the full text of related articles, cross-citations were identified, and the pooled data were then discussed. Results revealed a higher prevalence in accessory root/root canal variations in mandibular anterior teeth than in maxillary counterparts. However, maxillary incisor teeth revealed the highest tendency for accessory root/root canal aberrations caused by anomalies such as dens invaginatus and palato-gingival groove. Primary anterior teeth may also exhibit external and internal anatomical variations in the root, especially maxillary canines. Therefore, dental practitioners should thoroughly assess all teeth scheduled for root canal treatment to prevent the undesirable consequences caused by inadequate debridement of accessory configurations of the root canal system. PMID:26174943

  5. Care of astronomical telescopes and accessories a manual for the astronomical observer and amateur telescope maker

    Pepin, M Barlow

    2006-01-01

    This is complete guide for anyone who wants to understand more than just the basics of astronomical telescopes and accessories, and how to maintain them in the peak of condition. The latest on safely adjusting, cleaning, and maintaining your equipment is combined with thoroughly updated methods from the old masters.

  6. Accessory enzymes influence cellulase hydrolysis of the model substrate and the realistic lignocellulosic biomass.

    Sun, Fubao Fuebiol; Hong, Jiapeng; Hu, Jinguang; Saddler, Jack N; Fang, Xu; Zhang, Zhenyu; Shen, Song

    2015-11-01

    The potential of cellulase enzymes in the developing and ongoing "biorefinery" industry has provided a great motivation to develop an efficient cellulase mixture. Recent work has shown how important the role that the so-called accessory enzymes can play in an effective enzymatic hydrolysis. In this study, three newest Novozymes Cellic CTec cellulase preparations (CTec 1/2/3) were compared to hydrolyze steam pretreated lignocellulosic substrates and model substances at an identical FPA loading. These cellulase preparations were found to display significantly different hydrolytic performances irrelevant with the FPA. And this difference was even observed on the filter paper itself when the FPA based assay was revisited. The analysis of specific enzyme activity in cellulase preparations demonstrated that different accessory enzymes were mainly responsible for the discrepancy of enzymatic hydrolysis between diversified substrates and various cellulases. Such the active role of accessory enzymes present in cellulase preparations was finally verified by supplementation with β-glucosidase, xylanase and lytic polysaccharide monooxygenases AA9. This paper provides new insights into the role of accessory enzymes, which can further provide a useful reference for the rational customization of cellulase cocktails in order to realize an efficient conversion of natural lignocellulosic substrates. PMID:26320713

  7. Transrectal ultrasonographic characterization of the accessory sex glands, pelvic urethra, and ureters in normal geldings.

    Schnobrich, Maria Raymond; Turner, Regina Orstaglio; Belcher, Carolyn Niles; Slack, JoAnn

    2016-01-15

    Transrectal ultrasound of the internal urogenital tract may be used to aid in the diagnosis of reproductive tract and urinary tract pathology in both stallions and geldings. Abnormalities of the accessory sex glands of geldings are uncommon, although prostatic masses have recently been described in adult geldings presenting with dysuria, stranguria, and/or hematuria. The purpose of this study was to describe the normal ultrasonographic features and sizes of the accessory sex glands, caudal ureters, and pelvic urethra in clinically normal geldings. Eleven healthy geldings with no history of urogenital tract pathology were evaluated by a single observer experienced in ultrasound of the stallion accessory sex glands. The ultrasonographic appearance, relative anatomic relationships and sizes of the accessory sex glands, caudal ureters, and pelvic urethra were investigated using both rectal linear array and microconvex array transducers. Summary statistics including mean, standard error, confidence intervals, and range were calculated for each structure. There were no statistically significant differences in measurements between the left and right sides of paired structures or between measurements obtained with different transducers. Fluid was present in the seminal vesicles of 7 of 9 subjects. Midline cysts of the urethra as well as bulbourethral gland and prostatic cysts were identified. The normal reference ranges defined in this study will be useful in the clinical evaluation of geldings with suspected internal urogenital tract pathology. PMID:26483314

  8. Automatic Inspection and Processing of Accessory Based on Vision Stitching and Spectral Illumination

    Wen-Yang Chang

    2014-08-01

    Full Text Available The study investigates automatic inspection and processing of the stem accessories based on vision stitching and spectral illumination. The vision stitching mainly involves algorithms of white balance, scale-invariant feature transforms (SIFT and roundness for whole image of automatic accessory inspection. The illumination intensities, angles, and spectral analyses of light sources are analyzed for image optimal inspections. The unrealistic color casts of feature inspection is removed using a white balance algorithm for global automatic adjustment. The SIFT is used to extract and detect the image features for big image stitching. The Hough transform is used to detect the parameters of a circle for roundness of the bicycle accessories. The feature inspections of a stem contain geometry size, roundness, and image stitching. Results showed that maximum errors of 0°, 10°, 30°, and 50° degree for the spectral illumination of white light LED arrays with differential shift displacements are 4.4, 4.2, 6.8, and 3.5 %, respectively. The deviation error of image stitching for the stem accessory in x and y coordinates are 2 pixels. The SIFT and RANSAC enable to transform the stem image into local feature coordinates.

  9. Measurement of spleen size using gamma camera scintigraphy in essential thrombocythaemia

    Revesz, P. (Department of Medicine, Oestra Hospital, University of Goeteborg, Goeteborg (Sweden)); Carneskog, J.; Wadenvik, H.; Kutti, J. (Haematology Section, Department of Medicine, Sahlgrenska Hospital, University of Goeteborg, Goeteborg (Sweden)); Jarneborn, L. (Department of Clinical Physiology, Oestra Hospital, University of Goeteborg, Goeteborg (Sweden))

    1993-09-01

    By using gamma camera imaging the spleen size was determined in 33 consecutive patients with essential thrombocythaemia (ET) and in 33 consecutive patients with reactive thrombocytosis (RT). All ET patients were newly diagnosed and had not received myelosuppressive treatment prior to study; they all fulfilled the criteria for ET as established by the Polycythemia Vera Study Group. In both posterior and lateral projections, the spleen area in the group of ET patients was significantly larger than in the RT patients. The present study has shown that 39% of ET patients at diagnosis have splenic enlargement. Evaluation of Spleen size is therefore a useful diagnostic test in patients presenting with unexplained thrombocytosis. (au) (15 refs.).

  10. CT of the liver and spleen with EOE-13: review of 225 examinations

    Miller, D.L.; Vermess, M.; Doppman, J.L.; Simon, R.M.; Sugarbaker, P.H.; O' Leary, T.J.; Grimes, G.; Chatterji, D.G.; Willis, M.

    1984-08-01

    EOE-13 is an experimental liver-spleen-specific computed tomographic (CT) contrast agent developed at the National Institutes of Health. Experience with this agent in 225 clinical examinations is described. On average, use of EOE-13 increases the attenuation of normal liver by 32.5 H and that of normal spleen by 52.3 H. Tumors in these organs increase only 2.6 H, making them more easily detectable. Most of the iodine in EOE-13 appears to clear from the liver and spleen by 24 hr after injection. No deaths or permanent morbidity have been observed. The complication rate is 3.6%. EOE-13 is valuable for the detection of hepatic and splenic tumors.

  11. The role of the canine spleen in cardiovascular homeostasis during halothane anesthesia.

    Merin, R G; Hoffman, W L; Kraus, A L

    1977-01-01

    Barbiturate anesthesia is known to increase canine splenic sequestration of red blood cells. In our laboratory, high halothane concentrations have produced a decreased arterial hematocrit in the dog. In order to assess the role of the spleen in this phenomenon, central hematocrit, plasma volume, and ventricular hemodynamics were studied at low and high halothane concentrations before and after splenectomy in the same group of dogs. Although the hematocrit difference was less after splenectomy, it was not abolished. In addition, there was more cardiovascular depression by equivalent or lower halothane doses after splenectomy. It appears that the dog has other areas of red cell sequestration than the spleen accounting for the persistently lower hematocrit with high halothane concentrations after splenectomy. The modifying effect of the canine spleen on the circulatory depression produced by halothane should be taken into account when the drug is used in the dog. PMID:923020

  12. Effects of androgen on transient endogenous spleen colonies and other hemopoietic stem cells in mice

    To clarify the effects of androgen on hemopoiesis in mice, we investigated changes in hemopoietic stem cells at various stages of differentiation after injection of 19-nandrolone decanoate (19-ND). 19-ND induced (a) a marked increase in the population of CFUe, especially in the spleen, and (b) a less significant increase in the number of CFUs, GM-CFC, and BFUe. The number of endogenous spleen colonies developed transiently on day 4 after irradiation (TE-CFU) increased significantly, and the initiation and induction of erythropoietic maturation was enhanced. Growth of the pluripotent stem cells (CFUs) assessed by endogenous spleen colony formation was influenced more than was the population size. Production of erythropoietin (Ep) in mice was not affected by the treatment with 19-ND. These results indicate that 19-ND affects mature precursors in erythroid cell lineage rather than pluripotent stem cells and that the effect is unlikely to be induced through an increase in the production of Ep

  13. Laparoscopic distal pancreatectomy with preservation of the spleen and splenic vessels for pancreatic adenocarcinoma

    Yan-Guo Zheng

    2009-06-01

    Full Text Available Background: A laparoscopic surgery can be beneficial in a spleen-preserving distal pancreatectomy. Aims: This report shows a 60-year-old woman who presented to her persistent upper abdominal and bilateral lumbodorsal distending pain for one year. A computed tomography scan demonstrated a 4cm×5cm×5cm solid space-occupying mass in the distal pancreas. The patient was referred to minimally invasive surgery service for resection of the pancreatic lesion. Methods: A laparoscopic spleen-preserving distal pancreatectomy was performed. Results: The mass was completely excised, the pathological examination revealed pancreatic adenocarcinoma with grade II. The postoperative advantages of this approach were the early return of bowel function, minimal complications, and early resumption of normal activities. Conclusions: This case illustrates that minimally invasive surgery in the performance of a spleen-and-splenic-vessel preserving distal pancreatectomy is a feasible procedure without compromising the splenic function.

  14. The role of splenic implants in spleen injuries and postoperative immunity

    Jovanović Milan M.

    2004-01-01

    Full Text Available Introduction Spleen preservation by autotransplantation is indicated in cases of injuries which result with conquassation or total devascularization of this organ. Material and methods Thirty dogs, experimental group, had multiple, devascularized spleen injuries and underwent splenectomy and splenic autotransplantation. The same number of animals were treated by primary splenectomy (control group. Seventy five days later, animals from both groups were exposed to pneumococcal sepsis - by intravenous inoculation of sublethal pneumococcal doses, in order to estimate the immunity of lienal implants and compare the mortality rate between these two groups. Results Positive hemoculture, as well as logarithmic increase of diplococci in blood samples was established in all 60 animals. Higher mortality rate and significantly higher pneumococcal growth was established in control, compared to experimental group. Conclusion These results point to the important role of lienal implants in total immunity and advantage of autotransplantation compared to conventional splenectomy, in cases of most severe and nonreconstructibile spleen injuries.

  15. Histopathology effects of nickel nanoparticles on lungs, liver, and spleen tissues in male mice

    Ajdari, Marziyeh; Ziaee Ghahnavieh, Marziyeh

    2014-09-01

    Because of the classification of the nickel compounds as carcinogenic substances, there is a need for in vivo tests to nickel nanoparticles (NiNPs) for observing their effects on health experimentally. Spherical NiNPs with 10 nm in diameter and 75 ppm concentration were applied for investigating their toxicities within male albino mice as an in vivo model. We randomly made sham group, control group, and 75 ppm group (with five animals in each group). Then, the nanoparticles were injected into mice intraperitonealy for 7 days and after that their lungs, liver, and spleen were removed for histopathological observations. At the end of the test, section microscopic observations of liver, spleen, and lung in sham and control groups showed normal tissues but these tissues underwent significant abnormal effects in 75 ppm group. NiNPs can cause undesirable effects in lungs, liver, and spleen tissues with same condition of this study.

  16. Resistance of neonatal mice to scrapie is associated with inefficient infection of the immature spleen.

    Ierna, Michelle; Farquhar, Christine F; Outram, George W; Bruce, Moira E

    2006-01-01

    Previous studies demonstrated that neonatal mice up to about a week old are less susceptible than adult mice to infection by intraperitoneal inoculation with mouse-passaged scrapie. In peripherally inoculated adult mice, scrapie replicates in lymphoid tissues such as the spleen before invading the central nervous system. Here, we investigated scrapie susceptibility in neonatal mice in more detail, concentrating on spleen involvement. First, we demonstrated that neonatal mice are about 10 times less susceptible than adults to intraperitoneal scrapie inoculation. Then we injected mice intraperitoneally with a scrapie dose that produced disease in all mice inoculated at 10 days or older but in only about a third of neonatally inoculated mice. In this experiment, spleens collected 70 days after scrapie injection of mice 10 days old or older almost all contained pathological prion protein, PrPSc, and those that were bioassayed all contained high infectivity levels. In contrast, at this early stage, only two of six spleens from neonatally inoculated mice had detectable, low infectivity levels; no PrPSc was detected, even in the two spleens. Therefore, neonatal mice have an impaired ability to replicate scrapie in their spleens, suggesting that replication sites are absent or sparse at birth but mature within 10 days. The increase in susceptibility with age correlated with the first immunocytochemical detection of the normal cellular form of prion protein, PrPc, on maturing follicular dendritic cell networks. As lymphoid tissues are more mature at birth in sheep, cattle, and humans than in mice, our results suggest that in utero infection with scrapie-like agents is theoretically possible in these species. PMID:16352571

  17. Leptospirosis mimicking sepsis after orthopedic surgery: a case report

    C. S. Abboud

    2001-10-01

    Full Text Available We report a case of leptospirosis that occurred after elective surgery involving tendon transfer and shoulder arthroscopy. The disease mimicked hospital infection after orthopedic surgery and was at first misdiagnosed as post-operative sepsis. The patient was 60 year old female that developed sepsis with hypotension, shock, bleeding, jaundice and renal insufficiency 4 hours after surgery. Shock treatment procedures were performed and broad spectrum antibiotic therapy was used with coverage for bacteria acquired in hospitals. A careful investigation was carried out by the Hospital Infection Control Service in search of the possible source of the infection. After clinical evaluation by a specialist in infectious diseases, the hypothesis of leptospirosis was put forward based on clinical and epidemiological data. The hypothesis was later confirmed by the positive result of serological tests with the microagglutination method that yielded 1:800 and then 1:12,600 7 days later. This is the first reported case of leptospirosis manifest directly following surgery, mimicking postoperative sepsis.

  18. Amplification of the spleen macrophage population in malaria: possible role of a factor chemotactic for blood mononuclear cells

    The mechanism of amplification of the splenic macrophages' population was investigated using mice infected with malaria as a model of an obligate intravascular infection. It was observed that these macrophages derived from blood monocytes rather than by local proliferation in the spleen. A factor, chemotactic for blood mononuclear cells, was present in spleen cells shortly after infection and preceded detectable increases in spleen macrophage number by 48 hours. This factor, in concert with spleen derived macrophage migration inhibition factor, may be important in the amplification of splenic macrophage population in intravascular infections

  19. Locally advanced leiomyosarcoma of the spleen. A case report and review of the literature

    Recchia Franco

    2007-11-01

    Full Text Available Abstract Background Leiomyosarcomas are rare tumours, predominantly localized in the stomach, small intestine and retroperitoneum. Only one case of primary leiomyosarcoma of the spleen is described in human beings in literature. Case presentation We report a case of locally advanced primary leiomyosarcoma of the spleen in a 54 year-old woman, diagnosed only after splenectomy, performed with the suspicion of splenic haematoma. Conclusion Due to the lack of cases, no specific chemotherapy regimen has been tested to provide a longer survival.

  20. Regional lymph nodes of liver and spleen: topographic evaluation based on CT examinations of Thorotrast patients

    The formerly used contrast medium Thorotrast is stored in liver (60 %), spleen (30 %) and their regional lymph nodes. CT scans of 22 Thorotrast patients were reviewed regarding the evaluation of the abdominal lymph nodes. Due to the high density of Thorotrast-accumulating lymph nodes (> 500 HU) and the excellent contrast sensitivity of CT, lymph nodes less than 0.4 cm in diameter can be imaged. In all more than 1300 lymph nodes could be detected (mean 63 ± 24 per patient). The goal of the study was to describe the normal topographic anatomy of the regional lymph nodes of liver and spleen, which can not be visualised by bipedal lymphography. (orig.)

  1. Copper induced immunotoxicity promote differential apoptotic pathways in spleen and thymus

    Highlights: ► Copper-induced ROS generation and mitochondrial trans-membrane potential changes result in different consequences in spleen and thymus. ► Inflammation appeared in both the spleen and thymus after to copper treatment. ► Apoptosis in the spleen appears to follow a p53-independent pathway. ► Apoptosis in the thymus appears to follow a p53-dependent intrinsic and extrinsic pathway. ► In both the spleen and thymus, the CD4+ T cell population decreased and CD8+ T cell population increased after copper treatment. - Abstract: Inorganic copper, such as that in drinking water and copper supplements, largely bypasses the liver and enters the free copper pool of the blood directly and that promote immunosuppression. Nevertheless, the signaling pathways underlying copper-induced immune cell death remains largely unclear. According to our previous in vivo report, to evaluate the further details of the apoptotic mechanism, we have investigated how copper regulates apoptotic pathways in spleen and thymus. We have analyzed different protein expression by western blotting and immunohistochemistry and mRNA expression by RT-PCR and gel electrophoresis. We also have measured mitochondrial trans-membrane potential, ROS and CD4+ and CD8+ population by flow cytometry. Sub lethal doses of copper in spleen and thymus of in vivo Swiss albino mice promote different apoptotic pathways. In case of spleen, ROS generation and mitochondrial trans-membrane potential changes promotes intrinsic pathway of apoptosis that was p53 independent, ultimately leads to decrease in CD4+ T cell population and increase in CD8+ T cell population. However in case of thymus, ROS generation and mitochondrial trans-membrane potential changes lead to death receptor that regulate extrinsic and intrinsic pathways of apoptosis and the apoptotic mechanism which was p53 dependent. Due to copper treatment, thymic CD4+ T cell population decreased and CD8+ T cell population was increased or

  2. Investigating Consumer Insight by Using Completion Techniques: A Case Study of a Motorcycle Accessory Shop in Thailand

    2012-01-01

    Full Text Available With almost 10% of the world’s motorcycles in use in Thailand, this indicates that Thailand is a big market for motorcycle accessories in the world. This qualitative research aims to investigate consumer insight by using completion techniques (sentence completion and story completion. Three respondents were deployed by using accidental sampling. Respondents were recruited to complete questionnaires when they entered the motorcycle accessory shop and were reported as male, currently studying, and at least 12 years old. The research was conducted in a motorcycle accessory shop in Sakon Nakhon province, Thailand. From the results of the story completion tests, all participants agreed to take part in a promotion which gave a 10% discount for membership card holders. They came to the motorcycle accessory shop by the recommendation of friends (positive Word-Of-Mouth. Moreover, consumers are satisfied when a seller can give them information or suggestions on motorcycle accessories as well as providing good after-sales service. When motorcycle accessory shoppers are satisfied with a motorcycle accessory shop, they will return to the shop and hence demonstrate consumer loyalty.

  3. Incremental value of single photon emission tomography/computed tomography in 3-phase bone scintigraphy of an accessory navicular bone

    Accessory navicular bone is one of the supernumerary ossicles in the foot. Radiography is non diagnostic in symptomatic cases. Accessory navicular has been reported as a cause of foot pain and is usually associated with flat foot. Increased radio tracer uptake on bone scan is found to be more sensitive. We report a case highlighting the significance of single photon emission tomography/computed tomography in methylene diphosphonate bone scan in the evaluation of symptomatic accessory navicular bone where three phase bone scan is equivocal

  4. Monoclonal origin of B lymphocyte colony-forming cells in spleen colonies formed by multipotential hemopoietic stem cells

    Lala, PK; Johnson, GR

    1978-01-01

    Spleen colonies produced by transplanting lethally irradiated mice with either 12 day fetal liver or adult bone marrow cells were found to contain B- lymphocyte colony-forming cells (BL-CFC) . The proportion of BL-CFC positive spleen colonies did not increase substantially between 8 and 14 days after transplantation, the range being 18-45 percent. However, the absolute number of BL-CFC per spleen colony varied considerably (between 1 and 10,318), although the majority of colonies contained less than 200 BL-CFC. Irrespective of the time after transplantation, smaller spleen colonies were found to have a higher frequency of BL-CFC than larger spleen colonies. To determine the possible clonal origin of BL-CFC from spleen colony- forming unit (CFU-S), CBA mice were injected with equal numbers of CBA and CBA T(6)/T(6) fetal liver or adult bone marrow cells. Analysis of 7-15-day spleen colonies demonstrated that 90 percent were either exclusively T(6) positive or T(6) negative and approximately equal numbers ofboth colony types were observed. B-lymphocyte colonies were grown and successfully karyotyped from 19 spleen colonies. When compared with the original spleen colony karyotype the B-lymphocyte colony cells karyotype was identical in all 19 cases. In 3 of the 19 colonies analyzed a mixture of T(6) positive and T(6) negative karyotypes was present and identical proportions of the karyotypes were present in the pooled B-lymphocyte colony cells and spleen colony cells. The data indicate that the B-lymphocyte colony-forming cells detected in spleen colonies are genuine members of the hemopoietic clone derived from the initiating hemopoietic stem cell (CFU-S). PMID:309918

  5. Effects of Sleep Deprivation on Mice Bone Marrow and Spleen B Lymphopoiesis.

    Lungato, Lisandro; Nogueira-Pedro, Amanda; Carvalho Dias, Carolina; Paredes-Gamero, Edgar Julian; Tufik, Sergio; D'Almeida, Vânia

    2016-06-01

    B lymphocytes are immune cells crucial for the maintenance and viability of the humoral response. Sleep is an essential event for the maintenance and integrity of all systems, including the immune system (IS). Thus, sleep deprivation (SD) causes problems in metabolism and homeostasis in many cell systems, including the IS. In this study, our goal was to determine changes in B lymphocytes from the bone marrow (BM) and spleen after SD. Three-month-old male Swiss mice were used. These mice were sleep deprived through the modified multiple platform method for different periods (24, 48, and 72 h), whereas another group was allowed to sleep for 24 h after 72 h of SD (rebound group) and a third group was allowed to sleep normally during the entire experiment. After this, the spleen and BM were collected, and cell analyses were performed. The numbers of B lymphocytes in the BM and spleen were reduced by SD. Additionally, reductions in the percentage of lymphocyte progenitors and their ability to form colonies were observed. Moreover, an increase in the death of B lymphocytes from the BM and spleen was associated with an increase in oxidative stress indicators, such as DCFH-DA, CAT, and mitochondrial SOD. Rebound was not able to reverse most of the alterations elicited by SD. The reduction in B lymphocytes and their progenitors by cell death, with a concomitant increase in oxidative stress, showed that SD promoted a failure in B lymphopoiesis. PMID:26517012

  6. Haemopoiesis in murine bone marrow and spleen after fractionated irradiation and repeated bone marrow transplantation. II

    Granulopoiesis was studied in mice repeatedly exposed to doses of 3 Gy of 60Co γ-rays at 4-day intervals up to a total dose of 24 Gy on the basis of total bone marrow cellularity follow-up and analysis of myelograms and splenograms. Half the number of the mice received lO6 nuclear cells of syngeneic bone marrow after each fractional radiation dose. After an initial steep decrease, the number of granuloid cells in the spleen increased about 30-fold between days 12 and 16 of the experiment (total dose 9 and 12 Gy, respectively). This increase was temporary and between days 20 and 24 (total dose 15 and 18 Gy, respectively) a steep decrease again occurred. At a low level (below 10% of the control value) the granuloid cells remained in the spleens of bone marrow recipients until the end of the experiment (day 37, total dose 24 Gy). The behavior of the granuloid compartment of hemopoiesis thus contrasts with findings in the erythroid compartment (Hofer et al., 1989) when high numbers of erythroid nuclear cells remained in the spleens of bone marrow recipients until the end of the experiment. On the whole, the influence of repeated bone marrow transplantation on granulopoiesis in the bone marrow and spleen is positive. Of the 22 comparisons made between bone marrow recipients and mice only irradiated, 14 differences are statistically significant, always in favor of bone marrow recipients. (author)

  7. Lymphangiomatosis of the spleen as a presentation of Gorham's disease

    Full text: Lymphangiomatosis of the spleen is a rare pathologic entity. It is considered to be a result of a developmental malformation of the lymphatic system and can involve the spleen alone or may be a part of multiorgan disease. We report a case of a 57-year old patient, hospitalized on the base of an astheno-adynamic syndrome with medically proven splenomegaly and pancytopenia. The result of the abdomen and pelvis CT was lypmhangiomatosis of the spleen, histologically verified after splenectomy. The imaging diagnostic methods showed one and the same type of pseudocystic bilateral changes in the iliac bone without periosteal reaction. The association of lymhangiomatosis with osteolytic changes directed us to the rare diagnosis Gorham‘s disease with so far reported around 200 cases. Gorham‘s disease, most often known also as Idiopathic Massive osteolysis or Disappearing Bone Disease, manifests in spontaneous and progressive osteolysis of the bone matrix as a result from abnormal vessel proliferation. Even more rarely it can demonstrate cystic changes in the spleen. At the same time 75% of all patients with proven lymphangiomatosis have bone changes too. The purpose of this case is not only to present one of the multiple faces of lymphangiomatosis with visceral involvement, but also to reveal that together with Gorham‘s disease they are a different aspect of one and the same illness

  8. Spleen morphology and vascularization in the alligator (Caiman crocodilus yacare – Daudin, 1802

    Alan Peres Ferraz de Melo

    2013-11-01

    Full Text Available The Caiman crocodilus yacare is found from northern Argentina to the southern Amazon basin, mainly occurring in Pantanal. Its food consists of fishes and other aquatic vertebrates and invertebrates, such as crabs, winkles, and insects. Its length can reach 3 meters and this species is important because it provides biological control of other animal species, by feeding on weak, old, and ill individuals, unable to escape its attack. A total of 15 alligators were used, young males and females, using histological techniques; injection techniques with Neoprene latex 450 and vinyl acetate; and radiographic techniques to observe particularities of spleen in this species. The organ has a conical shape, being thicker at its cranial end and tapering at its caudal end. Spleen involved the cranial mesenteric artery, which went towards the intestines, from its origin in the celiac artery until its middle third, through the splenic parenchyma in all preparations. Spleen irrigation in the alligator was originated from the celiac artery, through its branch, the cranial mesenteric artery, which branched into splenic arteries, only within this organ. The splenic veins showed up as the cranial, craniomedial, medial, and caudal splenic veins which drain from the splenic capsule to the medullary region, going through the cortical region and going towards the hepatic portal vein. Spleen in the alligator showed no correspondence between the arteries and veins responsible for the vascularization of a certain splenic territory, but one observed arteries irrigating and veins draining particular areas of the splenic parenchyma.

  9. Immune gene expression in the spleen of chickens experimentally infected with Ascaridia galli

    Dalgaard, Tina S.; Skovgaard, Kerstin; Norup, Liselotte R.;

    2015-01-01

    enable future vaccine development. In the present study, expression of immune genes in the chicken spleen during an experimental infection with A. galli was investigated using the Fluidigm (R) BioMark (TM) microfluidic qPCR platform which combines automatic high-throughput with attractive low sample and...

  10. Body mass, spleen mass and level of thyroid hormones in juvenile hypothyroid rats

    Roksandić Dragutin

    2006-01-01

    Full Text Available In this paper, the effect of hypothyroidism on body mass and spleen mass of rats was examined during the prenatal and early juvenile periods. Hypothyroidism was induced by the application of propylthiouracil (PTU in drinking water to the mothers from the first day of gravidity and during lactation, and the offspring were sacrificed on the 14th and 21st days after birth. The body mass of the juvenile rats was measured just before they were sacrificed. The concentrations of triiodothyronine (T3 and thyroxine (T4 in blood serum were determined in control and treated juvenile rats. The results indicate that PTU leads to a reduction in T3 and T4 serum concentrations in treated juvenile rats. Treated juvenile rats had a bigger body mass and spleen mass in comparison with control animals. These data indicate that hypothyroidism induced in the prenatal and early juvenile period leads to an increase in the body mass and spleen mass and disrupts the normal development of the spleen in the course of the examined period. .

  11. Characterization of a Phenotypically Unique Population of CD13+ Dendritic Cells Resident in the Spleen

    Zhuang, Yan; Mwangi, Waithaka; Brown, Wendy C.; Davis, William C.; Hope, Jayne C.; Palmer, Guy H.

    2006-01-01

    Immature dendritic cells (DCs) resident in bovine spleens represent a distinct CD11a+ CD11c+ CD13+ CD172+ CD205+ population compared to those circulating in peripheral blood or trafficking via afferent lymph. Upon cytokine-induced maturation, splenic DCs both efficiently present antigen in the stimulation of allogeneic lymphocyte proliferation and recall antigen-specific responses.

  12. Biomechanics of red blood cells in human spleen and consequences for physiology and disease.

    Pivkin, Igor V; Peng, Zhangli; Karniadakis, George E; Buffet, Pierre A; Dao, Ming; Suresh, Subra

    2016-07-12

    Red blood cells (RBCs) can be cleared from circulation when alterations in their size, shape, and deformability are detected. This function is modulated by the spleen-specific structure of the interendothelial slit (IES). Here, we present a unique physiological framework for development of prognostic markers in RBC diseases by quantifying biophysical limits for RBCs to pass through the IES, using computational simulations based on dissipative particle dynamics. The results show that the spleen selects RBCs for continued circulation based on their geometry, consistent with prior in vivo observations. A companion analysis provides critical bounds relating surface area and volume for healthy RBCs beyond which the RBCs fail the "physical fitness test" to pass through the IES, supporting independent experiments. Our results suggest that the spleen plays an important role in determining distributions of size and shape of healthy RBCs. Because mechanical retention of infected RBC impacts malaria pathogenesis, we studied key biophysical parameters for RBCs infected with Plasmodium falciparum as they cross the IES. In agreement with experimental results, surface area loss of an infected RBC is found to be a more important determinant of splenic retention than its membrane stiffness. The simulations provide insights into the effects of pressure gradient across the IES on RBC retention. By providing quantitative biophysical limits for RBCs to pass through the IES, the narrowest circulatory bottleneck in the spleen, our results offer a broad approach for developing quantitative markers for diseases such as hereditary spherocytosis, thalassemia, and malaria. PMID:27354532

  13. The onset of hemoglobin synthesis in spleens of irradiated mice after bone marrow transplantation

    Messenger RNA (mRNA) for globin was isolated from spleens of irradiated mice in which erythroid differentiation was induced by a bone marrow graft. The globin mRNA was isolated either by means of sucrose gradients of reticulocyte polysomal RNA or by affinity chromatography of total spleen RNA on poly (U)-sepharose. The globin mRNA was tested in a wheat embryo cell-free system. The appearance of mRNA in the spleen erythroid colonies was correlated with other parameters of erythroid differentiation such as globin synthesis, activity of delta-aminolevulinic acid synthetase and iron uptake. Poly(A) containing mRNA did appear already on the 3rd day after grafting. However, significant translational activity of globin mRNA could be demonstrated only one day later together with increase in globin synthesis and delta-aminolevulinic acid synthetase and enhanced iron uptake. In the second part of this study mouse spleen cells rich in erythroid elements were incubated with a specific heme synthesis inhibitor (isonicotinic acid hydrazide, INH) and the synthesis of 9 S RNA was estimated. It was found that a 40-minute incubation with INH reduced uridine incorporation into 9 S RNA fraction by about 40%. (author)

  14. Imaging findings in Langerhans` cell histiocytosis of the liver and the spleen in an adult

    Mampaey, S. [Dept. of Radiology, Aalsters Stedelijk Ziekenhuis, Aalst (Belgium)]|[Dept. of Radiology, University of Antwerp (Belgium); Warson, F. [Dept. of Anatomopathology, Aalsters Stedelijk Ziekenhuis, Aalst (Belgium); Hedent, E. van [Dept. of Radiology, Aalsters Stedelijk Ziekenhuis, Aalst (Belgium); Schepper, A.M. de [Dept. of Radiology, University of Antwerp (Belgium)

    1999-02-01

    We present a case of Langerhans` cell histiocytosis (LCH) of the liver and spleen in an adult. The imaging features are different from those in the few previously reported cases of individual organ involvement by LCH. (orig.) (orig.) With 2 figs., 5 refs.

  15. Evaluation of quantitative and objective criteria in liver-spleen scintigraphy for diagnosing cirrhosis of liver

    A prospective study was designed to evaluate the efficacy of quantitative parameters like liver span, liver right-to-left lobe ratio and spleen-to liver ratio in diagnosing cirrhosis of liver against the quantitative interpretation by experienced nuclear medicine physician

  16. 915 MHz microwave ablation with high output power in in vivo porcine spleens

    Objective: The purpose of this study was to evaluate the efficacy of 915 MHz microwave (MW) ablation with high output power in in vivo porcine spleens. Materials and methods: MW ablations were performed in 9 porcine spleens with an internally cooled 915 MHz antenna. Thermocouples were placed at 5, 10, 15, 20 mm away from the antenna to measure temperatures in real-time during MW emission. The energy was applied for 10 min at high output power of 60 W, 70 W or 80 W. Gross specimens were sectioned and measured to determine ablation size. Representative areas were examined by light microscopy and electron microscopy. Coagulation sizes and temperatures were compared among the three power groups. Results: Hematoxylin-eosin staining showed irreversible necrosis in the splenic coagulation area after MW ablation. As the power was increased, long-axis diameter enlarged significantly (p .05). The coagulation size of long-axis and short-axis diameter with 80 W in vivo spleen ablation was 6.43 ± 0.52 and 4.95 ± 0.30 cm, respectively. With the increase of output power, maximum temperatures at 5, 10, 15, 20 mm from the antenna were increased accordingly (p oC respectively. Conclusion: With internally cooled antenna and high output power, 915 MHz MW ablation in the spleen could produce irreversible tissue necrosis of clinical significance. MW ablation may be used as a promising minimally invasive method for the treatment of splenic diseases.

  17. Morphological studies on the subchronic toxicity of a standardized liver- and spleen-extract.

    Leder, G H; Leder, O

    1990-02-01

    A short-term safety study on the liver- and spleen-extract Factor AF2 has been carried out. Daily injections of 4 or 33.3 mg/kg body weight for six weeks were not followed by drug-induced changes. PMID:2334459

  18. Lysosomal acid lipase deficiency in rats: Lipid analyses and lipase activities in liver and spleen

    We report the biological characterization of an animal model of a genetic lipid storage disease analogous to human Wolman's disease. Affected rats accumulated cholesteryl esters (13.3-fold), free cholesterol (2.8-fold), and triglycerides (5.4-fold) in the liver, as well as cholesteryl esters (2.5-fold) and free cholesterol (1.33-fold) in the spleen. Triglycerides did not accumulate, and the levels actually decreased in the spleen. Analysis of the fatty acid composition of the cholesteryl esters and triglycerides showed high percentages of linoleic acid (18:2) and arachidonic acid (20:4) in both organs, especially in the liver. No accumulation of phospholipids, neutral glycosphingolipids, or gangliosides was found in the affected rats. Acid lipase activity for [14C]triolein, [14C]cholesteryl oleate, and 4-methyl-umbelliferyl oleate was deficient in both the liver and spleen of affected rats. Lipase activity at neutral pH was normal in both liver and spleen. Heterozygous rats showed intermediate utilization of these substrates in both organs at levels between those for affected rats and those for normal controls, although they did not accumulate any lipids. These data suggest that these rats represent an animal counterpart of Wolman's disease in humans

  19. Mimicking unfolding motion of a beetle hind wing

    MUHAMMAD Azhar; PARK Hoon C; HWANG Do Y; BYUN Doyoung; GOO Nam S

    2009-01-01

    This paper presents an experimental research aiming to realize an artificial hind wing that can mimic the wing unfolding motion of Allomyrina dichotoma, an insect in coleopteran order. Based on the understanding of working principles of beetle wing folding/unfolding mechanisms, the hind wing unfolding motion is mimicked by a combination of creative ideas and state-of-art artificial muscle actuator. In this work, we devise two types of artificial wings and the successfully demonstrate that they can be unfolded by actuation of shape memory alloy wires to provide actuation force at the wing base and along the leading edge vein. The folding/unfolding mechanisms may provide an insight for portable nano/micro air vehicles with morphing wings.

  20. Amiodarone-induced pulmonary toxicity mimicking acute pulmonary edema.

    Fabiani, Iacopo; Tacconi, Danilo; Grotti, Simone; Brandini, Rossella; Salvadori, Claudia; Caremani, Marcello; Bolognese, Leonardo

    2011-05-01

    Amiodarone is a highly effective antiarrhythmic drug. Its long-term use may, however, lead to several adverse effects, with pulmonary toxicity being the most serious. The article presents the case of a 78-year-old woman with a history of cardiac surgery, who after 2 years of amiodarone therapy for prophylactic treatment of atrial fibrillation developed amiodarone pneumonitis mimicking an acute pulmonary edema. The patient failed to respond to diuretic therapy and several courses of anti-infective therapy. Differential diagnosis of different causes of pulmonary infiltrates did not demonstrate any other abnormality. Lung biopsy findings were consistent with the diagnosis of amiodarone pneumonitis. Given the widespread use of amiodarone as an antiarrhythmic agent, pneumologists and cardiologists should consider this important adverse effect as a differential diagnosis of pulmonary distress refractory to therapy in all patients treated with amiodarone who present with respiratory symptoms and pneumonia-like illness. PMID:19924000

  1. Myelodysplastic changes mimicking MDS following treatment for osteosarcoma

    Løhmann, Ditte

    -MDS/AML) is a feared long-term complication of paediatric cancer including osteosarcoma. Few develop t-MDS/AML, but it is not known how many have significant haematological changes after finishing treatment for osteosarcoma. In this study we reviewed biochemistry from a consecutive series of children for up....... In one case MDS (refractory anaemia with excess blasts) with monosomy 7 was found and a hematopoietic stem cell transplant was performed. In the other case MDS without excess of blasts was found and a spontaneous normalization of the biochemistry occurred. In conclusion in our study most patients......Myelodysplastic changes mimicking MDS following treatment for osteosarcoma Ditte Juel Adolfsen Løhmann, Department of Pediatrics, Aarhus University Hospital, Skejby, Denmark Authors: Ditte Juel Adolfsen Løhmann and Henrik Hasle. Therapy-related myelodysplastic syndrome/acute myeloid leukaemia (t...

  2. Oral manifestion of Langerhans cell histiocytosis mimicking inflammation

    K S Divya

    2014-01-01

    Full Text Available Langerhans cell histiocytosis (LCH is a rare idiopathic disease characterized by the clonal proliferation of Langerhans cells. LCH affects five children per million population. The peak incidence is from 1 to 4 years of age. LCH involves the head and neck region quite commonly. Oral soft tissue lesions are also common. The differential diagnosis of oral LCH includes leukemia, neutropenia, prepubertal periodontitis, hypophosphatasia, fibrous dysplasia, and Papillon-Lefevre syndrome. The prognosis of LCH depends on early detection and appropriate management. Surgical management alone is used in 50% of cases with an additional 23% of the lesions being treated with both surgery and radiation therapy. A case of LCH in a 6-year-old girl involving the mid root level of developing first permanent molar with a floating developing tooth bud of permanent second molar mimicking an inflammation is reported.

  3. Giant Ectopic Ureter Mimicking Pelvic Organ Prolapse: A Case Report

    Adnan Simsir

    2011-01-01

    Full Text Available Ectopic ureter is one of the most common urinary tract anomalies. We, herein, present a case of a giant ureter with ectopic orifice, mimicking pelvic organ prolapse, which is the first in the literature. A 59-year-old female patient presenting with frequently recurrent urinary tract infection had grade 3 pelvic organ prolapse. On examination, the organ producing the appearance of prolapse was found to be a right ureter of giant size and was obstructed by a large stone at the distal segment. The proximal end of the ureter ended blindly. After exploration, the stone was removed, the ureter was detached from the urethra, and the lumen was tied off and cut 5 cm proximally. At 6 months postoperatively, the patient is being followed up without any clinical problems. In such cases with nonfunctioning renal segment draining proximally, the chance of cure can be obtained without a need for a comprehensive intervention such as total abdominal ureterectomy.

  4. Liquid optical phantoms mimicking spectral characteristics of laboratory mouse biotissues

    Loginova, D. A.; Sergeeva, E. A.; Krainov, A. D.; Agrba, P. D.; Kirillin, M. Yu

    2016-06-01

    Optical phantoms mimicking optical properties of real biotissues in the visible and IR spectral regions are developed based on measurements of the spectral characteristics of ex vivo samples of laboratory mouse biotissues. The phantoms are composed of aqueous solutions of Lipofundin, Indian ink and red ink with different spectral characteristics. The deviations of the measured absorption and scattering coefficients of phantoms in the wavelength range 480 – 580 nm from the corresponding values for real biotissues do not exceed 25% and 2%, respectively. For phantoms in the wavelength region 580 – 880 nm, the deviations of the absorption coefficient do not exceed 40% and the deviations of the scattering coefficient do not exceed 25%. These values, in general, fall within the range of variations for different individual mice of one strain.

  5. Epineurium-mimicking chitosan conduits for peripheral nervous tissue engineering.

    Nawrotek, Katarzyna; Tylman, Michał; Rudnicka, Karolina; Gatkowska, Justyna; Wieczorek, Marek

    2016-11-01

    In this investigation, we report on a fabrication method of epineurium-mimicking tubular conduits based on electrodeposition from chitosan solution. The pre-enrichment of electrodeposition solution with hyaluronic acid and/or collagen components results in structures which structural, morphological, and physicochemical properties can be controlled. In order to determine the optimal composition of the initial chitosan solution resulting in conduits meeting the requirements imposed on peripheral nerve implants, we perform chemical, physical, and biological studies. Both the molecular weight of hyaluronic acid and the concentration of additives are found to be crucial for the final mechanical as well as biological performance of conduits. Because, the obtained structures show biocompatibility when contacting with a mouse hippocampal cell line (mHippoE-18), we further plan to test their application potential on an animal model. PMID:27516256

  6. Impedance of tissue-mimicking phantom material under compression

    Barry Belmont

    2013-02-01

    Full Text Available The bioimpedance of tissues under compression is a field in need of study. While biological tissues can become compressed in a myriad of ways, very few experiments have been conducted to describe the relationship between the passive electrical properties of a material (impedance/admittance during mechanical deformation. Of the investigations that have been conducted, the exodus of fluid from samples under compression has been thought to be the cause of changes in impedance, though until now was not measured directly. Using a soft tissue-mimicking phantom material (tofu whose passive electrical properties are a function of the conducting fluid held within its porous structure, we have shown that the mechanical behavior of a sample under compression can be measured through bioimpedance techniques.

  7. Hepatic actinomycosis mimicking a malignant tumor: Three case reports

    Kwon, O Hyun; Kim, Jae Woon [Dept. of Radiology, Yeungnam University College of Medicine, Daegu (Korea, Republic of)

    2015-05-15

    Various forms of hepatic actinomycosis can be observed on the imaging studies. We report here the imaging findings of three cases of hepatic actinomycosis, which presented as a solid mass mimicking a malignant tumor. With respect to their enhancement pattern on the contrast-enhanced CT and MR images, one case showed homogeneous and persistent enhancement throughout three phases, while the other two cases showed variable degrees of delayed enhancement with their own features during the portal and equilibrium phases, suggesting that they have abundant fibrosis at different stages. Also, normal vascular structures traversing the masses were noted in all three cases. One core needle biopsy and two surgical resections were performed, and the masses were pathologically proven to be hepatic actinomycosis. In conclusion, we need to be aware that a hepatic tumor with abundant fibrosis, in which the normal vasculature is traversing, can be diagnosed as hepatic actinomycosis.

  8. Engineered nanoparticles mimicking cell membranes for toxin neutralization.

    Fang, Ronnie H; Luk, Brian T; Hu, Che-Ming J; Zhang, Liangfang

    2015-08-01

    Protein toxins secreted from pathogenic bacteria and venomous animals rely on multiple mechanisms to overcome the cell membrane barrier to inflict their virulence effect. A promising therapeutic concept toward developing a broadly applicable anti-toxin platform is to administer cell membrane mimics as decoys to sequester these virulence factors. As such, lipid membrane-based nanoparticulates are an ideal candidate given their structural similarity to cellular membranes. This article reviews the virulence mechanisms employed by toxins at the cell membrane interface and highlights the application of cell-membrane mimicking nanoparticles as toxin decoys for systemic detoxification. In addition, the implication of particle/toxin nanocomplexes in the development of toxoid vaccines is discussed. PMID:25868452

  9. Malignant fibrous histiocytoma presenting as hemoperitoneum mimicking hepatocellular carcinoma rupture

    2007-01-01

    Malignant fibrous histiocytoma (MFH) is a pleomorphic mesenchynal sarcoma. It is uncommonly arises primarily from the intra-peritoneal cavity. Primary peritoneal MFH with tumor bleeding and rupture is rare. We describe the imaging features of a 70-year-old patient presenting with ruptured hemorrhagic peritoneal MFH at subhepatic area, accompanied by massive hemoperitoneum,mimicking a ruptured pedunculated hepatocellular carcinoma. Computed tomography (CT) revealed a large heterogeneous enhanced subhepatic mass with adjacent liver, gallbladder and colon invasion. Tumor hemorrhage and rupture complicated with peritoneal seeding and massive bloody ascites were also detected.Angiography showed a hypervascular tumor fed by enlarged right hepatic arteries, cystic artery and omental branches of gastroepiploic artery. The patient underwent laparotomy for tumor resection, but the tumor recurred one month after operation. To our knowledge, the CT appearance of ruptured intraperitoneal MFH complicated by hemoperitoneum has not been previously described.

  10. Hepatic actinomycosis mimicking a malignant tumor: Three case reports

    Various forms of hepatic actinomycosis can be observed on the imaging studies. We report here the imaging findings of three cases of hepatic actinomycosis, which presented as a solid mass mimicking a malignant tumor. With respect to their enhancement pattern on the contrast-enhanced CT and MR images, one case showed homogeneous and persistent enhancement throughout three phases, while the other two cases showed variable degrees of delayed enhancement with their own features during the portal and equilibrium phases, suggesting that they have abundant fibrosis at different stages. Also, normal vascular structures traversing the masses were noted in all three cases. One core needle biopsy and two surgical resections were performed, and the masses were pathologically proven to be hepatic actinomycosis. In conclusion, we need to be aware that a hepatic tumor with abundant fibrosis, in which the normal vasculature is traversing, can be diagnosed as hepatic actinomycosis.

  11. Primary oral leishmaniasis mimicking oral cancer: a case report.

    Celentano, A; Ruoppo, E; Mansueto, G; Mignogna, M D

    2015-04-01

    Primary mucosal leishmaniasis is a rare infectious disease, particularly in immunocompetent patients. We present a 50-year-old patient with a 6-week history of a painful lesion of the left buccal mucosa that mimicked cancer. The exophytic lesion looked invasive, and we took an incisional biopsy specimen to exclude cancer. The diagnosis of leishmaniasis was unexpected, and the patient was successfully treated with amphotericin B for five weeks. After five months the patient had a visceral recurrence. Chronic exophytic and ulcerated mucosal lesions that do not heal within 3-4 weeks should be regarded as the first signs of oral cancer, but primary oral leishmaniasis can easily mimic it. PMID:25701438

  12. Optofluidic phantom mimicking optical properties of porcine livers

    Long, Ruiqi [Texas A& M University; King, Travis [Texas A& M University; Akl, Tony [Texas A& M University; Ericson, Milton Nance [ORNL; Wilson, Mark A. [University of Pittsburgh School of Medicine, Pittsburgh PA; Cote, Gerard L. [Texas A& M University; McShane, Michael J. [Texas A& M University

    2011-01-01

    One strategy for assessing efficacy of a liver transplant is to monitor perfusion and oxygenation after transplantation. An implantable optical sensor is being developed to overcome inadequacies of current monitoring approaches. To facilitate sensor design while minimizing animal use, a polydimethylsiloxane (PDMS)-based liver phantom was developed to mimic the optical properties of porcine liver in the 630-1000 nm wavelength range and the anatomical geometry of liver parenchyma. Using soft lithography to construct microfluidic channels in pigmented elastomer enabled the 2D approximation of hexagonal liver lobules with 15mm sinusoidal channels, which will allow perfusion with blood-mimicking fluids to facilitate the development of the liver perfusion and oxygenation monitoring system.

  13. Malignant Mesothelioma Mimicking Invasive Mammary Carcinoma in a Male Breast

    Mohamed Mokhtar Desouki

    2015-01-01

    Full Text Available Malignant mesothelioma is an uncommon tumor with strong association with asbestos exposure. Few cases of malignant pleural mesothelioma metastatic to the female breast have been reported. Herein, we presented, for the first time, a case of locally infiltrating malignant pleural mesothelioma forming a mass in the breast of a male as the first pathologically confirmed manifestation of the disease. Breast ultrasound revealed an irregular mass in the right breast which involves the pectoralis muscle. Breast core biopsy revealed a proliferation of neoplastic epithelioid cells mimicking an infiltrating pleomorphic lobular carcinoma. IHC studies showed the cells to be positive for calretinin, CK5/6, WT1, and CK7. The cells were negative for MOC-31, BerEp4, ER, and PR. A final diagnosis of malignant mesothelioma, epithelioid type, was rendered. This case demonstrates the importance of considering a broad differential diagnosis in the setting of atypical presentation with application of a panel of IHC markers.

  14. Cytomegalovirus colitis mimicking rectal carcinoma in an immunocompetent elderly woman.

    Chidlovskii, Elena; Deroux, Alban; Bernard, Sylvain; Couturier, Pascal

    2016-01-01

    Cytomegalovirus (CMV) colitis is uncommon in immunocompetent patients, despite a high seroprevalence rate of CMV in the general population. CMV infection has been described in individuals with compromised immune systems: in AIDS, under corticosteroid and immune modulating treatment, with cancer or haematological malignancies. Its most frequent clinical presentation is a necrotising ulcerative form; pseudotumoural CMV colitis has been described as highly exceptional. We report a case of CMV colitis mimicking rectal carcinoma in an immunocompetent elderly woman. The immunosenescence and protein-energy malnutrition increase incidence and severity of infectious diseases in elderly individuals. Immunosenescence may affect all aspects of immunity; severe protein malnutrition modifies mostly cellular immunity, growing susceptibility to infections. PMID:27166009

  15. Effect Of Colchicine On The Histology Of Spleen And Testis Of Albino Rats

    Nabila A. R. Abdel Motaal

    2006-06-01

    Full Text Available The aim of this work is to study the effect of colchicine administration on the histology of spleen and testis of albino rat. Colchicine was given in a daily dose of 3mg/kg body weight for five days. Animals were sacrificed at 1, 4 and 7 days following treatment. Histopathological studies of the spleen and testis were undertaken. Histological examination of spleen showed that colchicine caused histopathological changes in spleen manifested by massive haemorrhage, highly expanded red pulps accompanied by reduced white pulps with multi small degenerated areas, disturbed architecture, degenerated areas wer occupied by the hemorrhagic areas, prominent haemosiderin deposition, increased number of megakaryocytes in red pulp and subcapsular edema. These histopathological changes depend on the duration of colchicine intake. Histological examination of the testis one, four and seven days post treatment with colchicine showed dilatation and congestion of interstitial blood vessels, moderate degeneration of spermatogoneal cells, debris of spermatozoa could be detected in the lumen of the seminiferous tubules. The testis also suffered from interstitial edema with signs of fatty degeneration and degeneration of spermatogoneal cells lining some seminferous tubules. Complete destruction with hypocellularity in the spermatogenic layers in some seminiferous tubules and others contained only the debris of germ cells and disturbed nuclei of spermatogoneal cells with appearance of giant cells with highly reduced number of Leydig cells which contained pyknotic nuclei were also noticed in some examined sections. These results indicate that colchicine is considered as a toxic drug to the spleen and testis at double therapeutic doses as indicated by the histological changes.

  16. Leishmania donovani infection induces anemia in hamsters by differentially altering erythropoiesis in bone marrow and spleen.

    William P Lafuse

    Full Text Available Leishmania donovani is a parasite that causes visceral leishmaniasis by infecting and replicating in macrophages of the bone marrow, spleen, and liver. Severe anemia and leucopenia is associated with the disease. Although immune defense mechanisms against the parasite have been studied, we have a limited understanding of how L. donovani alters hematopoiesis. In this study, we used Syrian golden hamsters to investigate effects of L. donovani infection on erythropoiesis. Infection resulted in severe anemia and leucopenia by 8 weeks post-infection. Anemia was associated with increased levels of serum erythropoietin, which indicates the hamsters respond to the anemia by producing erythropoietin. We found that infection also increased numbers of BFU-E and CFU-E progenitor populations in the spleen and bone marrow and differentially altered erythroid gene expression in these organs. In the bone marrow, the mRNA expression of erythroid differentiation genes (α-globin, β-globin, ALAS2 were inhibited by 50%, but mRNA levels of erythroid receptor (c-kit, EpoR and transcription factors (GATA1, GATA2, FOG1 were not affected by the infection. This suggests that infection has a negative effect on differentiation of erythroblasts. In the spleen, erythroid gene expression was enhanced by infection, indicating that the anemia activates a stress erythropoiesis response in the spleen. Analysis of cytokine mRNA levels in spleen and bone marrow found that IFN-γ mRNA is highly increased by L. donovani infection. Expression of the IFN-γ inducible cytokine, TNF-related apoptosis-inducing ligand (TRAIL, was also up-regulated. Since TRAIL induces erythroblasts apoptosis, apoptosis of bone marrow erythroblasts from infected hamsters was examined by flow cytometry. Percentage of erythroblasts that were apoptotic was significantly increased by L. donovani infection. Together, our results suggest that L. donovani infection inhibits erythropoiesis in the bone marrow by

  17. Intervention effect of traditional Chinese medicine Yi Tang Kang on metabolic syndrome of spleen deficiency

    Xiao-Xi Liu; Yan Shi

    2015-01-01

    Objective:To investigate effects of herbal compoundYiTangKang on the spleen deficiency metabolic syndrome.Methods:Forty maleWistar rats were randomly divided into two groups: the normal control group and theMS spleen deficiency syndrome group.The control group rats were fed with standard diet and water, whileMS spleen deficiency syndrome group with high fat diet and low dose intraperitoneal injection ofstreptozocin, which swam to the endurance limit. After12 weeks, theMS spleen deficiency syndrome group was randomly divided into two groups, with13 rats in each group.Rats in model group were fed with high fat diet and continuouly administered with daily saline, and rats in intervention group with high fat diet were trated with traditionalChinese medicinesYiTangKang by gavage,2 mL/200 g at the same time every day.10 weeks later, the expression of serum proteomics was investigated through abdominal aortic puncture and separation of serum, using isotope labeling technique, high performance liquid chromatography and four bar-Orbitrap mass spectrometer.Results:After treatment with traditionalChinese medicine yitangkang, in the model group, important carboxylesterase and retinal guanylatecyclase2 precursor were upregulated.As for intervention group, these indesxes were raised, but immunoglobulinIgG, carnitine acetyltransferase, tubulin beta -5, andGanLu sugar binding proteinC were down-regulated.At the same time, some new biological active substances, such as protein tyrosine kinase, beta glucosidase were also found.Conclusions:TraditionalChinese medicinesYiTangKang could regulate glucose and lipid metabolism in rats with spleen deficiency syndrome.

  18. MR features of mice spleen lymphocytes labeled with super-paramagnetic iron oxide particles

    Objective: To investigate the feasibility of labeling mice spleen lymphocytes with superparamagnetic iron oxide (SPIO) and in vitro MR imaging of the labeled cells. Methods: Spleen lymphocytes of 5 mice were isolated and then labeled with SPIO of 100, 50, 25, 15, 10, 5 μg/ml, which was previously prepared with PLL. Prussian blue staining was performed to show the intracellular iron. Cell viability was compared among fresh, labeled and unlabeled cells. Different concentrations of mice spleen lymphocytes were screened using 3.0 T MR on T2WI, T2*WI and SWI sequences in vitro. Cell viability was compared using independent-sample t test between groups. The MRI values among different groups were compared using one-way ANOVA. Results: SPIO prepared with PLL could successfully label mice spleen lymphocytes, the optimum concentration of SPIO was 5 μg/ml. The Prussian blue staining showed intracellular blue spots and a labeling efficiency of(93.6 ± 2.1%. Three groups of fresh,labeled and unlabeled cells showed a Trypan blue staining result of (94.8 ± 3.1%, (88.7 ± 2.7%, and (88.9 ±3.2%, respectively; no statistically significant difference was found in cell viability between labeled and unlabeled lymphocytes (t=0.281, P>0.05); however, the cell viability of fresh cells were statistically significant higher than the labeled and unlabeled lymphocytes (t=8.125 and 7.253 respectively, P <0.05 for all). Among the T2WI,T2*WI and SWI sequences under the same concentrations of cells, the SWI sequence was the most sensitive. Conclusions: The mice spleen lymphocytes can be effectively labeled with SPIO with no impact on cell viability, and MR can be used to track these labeled cells in vitro. The SWI sequence is the most sensitive. (authors)

  19. Bulk enrichment of transplantable hemopoietic stem cell subsets from lipopolysaccharide-stimulated murine spleen.

    Ploemacher, R E; Brons, R H; Leenen, P J

    1987-02-01

    Counterflow centrifugal elutriation (CCE) in combination with density flotation centrifugation and fluorescence-activated cell sorting on wheat-germ agglutinin-FITC(WGA)-binding cells within the light-scatter "blast window" were used consecutively to enrich pluripotent hemopoietic stem cells (HSC) in bulk from lipopolysaccharide-stimulated mouse spleen. The medium-to-strong WGA + ve fraction contained 3.10(6) cells isolated from 3-4 X 10(9) spleen cells, with an average of 126% day-12 CFU-S and 65% day-8 CFU-S as calculated on the basis of their seeding fraction, suggesting that virtually all cells represented in vivo macroscopic colony formers. In view of the large differences reported elsewhere between stem cell subsets differing in reconstitutive capacity and secondary stem cell generation ability, we also studied various isolated cell fractions with respect to spleen colony formation, radioprotective ability, and spleen- and marrow- repopulating ability. Day-8 and day-12 CFU-S copurified when isolated by CCE. Cells from a fraction with high affinity for WGA were most highly enriched for their radioprotective ability (RPA) and their ability to repopulate the cellularity of the spleen and femur of irradiated recipients. This fraction contained virtually pure day-12 CFU-S. However, the ability to generate secondary day-12 CFU-S and CFU-GM in irradiated organs was enriched most in the medium WGA + ve cell fraction. MRA and SRA, according to the latter criteria, could therefore be partly separated from day-12 CFU-S and RPA on the basis of affinity for WGA. The data strongly suggest that at least part of all day-12 CFU-S have a high potential to proliferate and differentiate into mature progeny, but a relatively low self-renewal ability, and may therefore not be representative of the genuine stem cell. PMID:2880746

  20. Dynamics of bovine spleen cell populations during the response to acute Babesia bovis infection: an immunohistological study

    The spleen is the critical organ in defense against hemoparasitic diseases like babesiosis, responding to the pathogen in blood as it passes through the organ. As a lymphoid organ, the spleen is composed of cells whose role it is to orchestrate the engagement of infected erythrocytes and free parasi...

  1. Acoustical characterization of polysaccharide polymers tissue-mimicking materials.

    Cuccaro, Rugiada; Musacchio, Chiara; Giuliano Albo, P Alberto; Troia, Adriano; Lago, Simona

    2015-02-01

    Tissue-mimicking phantoms play a crucial role in medical ultrasound research because they can simulate biological soft tissues. In last years, many types of polymeric tissues have been proposed and characterized from an acoustical and a thermal point of view, but, rarely, a deep discussion about the quality of the measurements, in terms of the uncertainty evaluation, has been reported. In this work, considering the necessity to develop laboratory standards for the measurement of ultrasonic exposure and dose quantities, a detailed description of the experimental apparatuses for the sound speed and the attenuation coefficient measurements is given, focusing the attention on the uncertainty evaluation both of the results and analysis algorithms. In particular, this algorithm reveals a novel empirical relation, fixing a limit to the energy content (therefore limits the number of cycles) of the three parts in which the authors have proposed to divide the acoustical signal. Furthermore, the realisation of multi-components phantoms, Agar and Phytagel based tissue-mimicking gels along with others long chain molecules (dextrane or polyvinyl alcohol) and scattering materials (silicon carbide and kieselguhr) are investigated. This paper reports accurate speed of sound and attenuation coefficient measurements. Speed of sound is measured by a pulse-echo technique in far-field condition, using an optical glass buffer rod; while attenuation coefficient is determined by an insertion technique, using demineralized water as reference material. The experimental sound speed results are subjected to an overall estimated relative uncertainty of about 1.5% and the attenuation coefficient uncertainty is less than 2.5%. For the development of laboratory standards, a detailed analysis of the measurement uncertainty is fundamental to make sample properties comparable. The authors believe this study could represent the right direction to make phantoms characterizations referable and traceable

  2. Photosynthetic accessory pigments - Evidence for the influence of phycoerythrin on the submarine light field

    Hoge, Frank E.; Swift, Robert N.

    1990-01-01

    Upwelled water-leaving spectral radiances and the submarine light-field source are theorized to have the physical scattering and absorption effects of photosynthetic accessory pigments. A laser is employed to induce phycoerythrin pigment fluorescence, and the presence of the photosynthetic accessory pigment is measured in oceanic waters with a spectral fluorescence method. Experimental data from active-passive correlation spectroscopy demonstrate that water-leaving spectral radiances of about 600 nm are highly correlated with phycoerythrin pigment fluorescence. Because the data on the phycoerythrin and chlorophyll fluorescences are entered randomly in the correlation the results are considered unambiguous. An estimate of the photopigment is derived that agrees with measurements of its laser-induced fluorescence.

  3. The accessory soleus muscle: a case report and review of the literature

    A case of histologically proven accessory soleus muscle simulating of a soft tissue tumour in a young male is reported. The radiological features are demonstrated and reviewed. It is shown that CT scanning is more informative for the soft tissues, revealing the size and extent of the mass as well as its density. Magnetic Resonance Imaging is considered superior to CT in distinguishing soft tissue tumours from normal muscle. Like CT, it demonstrates a muscle-shaped mass that is iso-intense with normal muscle on all imaging sequences with identical T1 and T2 relaxation times. Ultrasound also reveals normal appearing muscle bundles with characteristic internal architecture. It is concluded that the role of diagnostic imaging in management of accessory soleus muscle is dual: Firstly, the radiological features are often sufficient to confirm the diagnosis without biopsy. Secondly, in symptomatic patients, imaging plays a role in planning surgery. 19 refs., 1 tab., 4 figs

  4. Accessory mental foramen: A rare anatomical variation detected by cone-beam computed tomography

    Torres, Marianna Guanaes Gomes; De Faro Valverde, Ludmila; Vidal, Manuela Torres Andion; Crusoe-Rebello, Ieda Margarida [Dept. of Oral Radiology, School of Dentistry, Federal University of Bahia, Salvador (Brazil)

    2015-03-15

    The mental foramen is a bilateral opening in the vestibular portion of the mandible through which nerve endings, such as the mental nerve, emerge. In general, the mental foramen is located between the lower premolars. This region is a common area for the placement of dental implants. It is very important to identify anatomical variations in presurgical imaging exams since damage to neurovascular bundles may have a direct influence on treatment success. In the hemimandible, the mental foramen normally appears as a single structure, but there are some rare reports on the presence and number of anatomical variations; these variations may include accessory foramina. The present report describes the presence of accessory mental foramina in the right mandible, as detected by cone-beam computed tomography before dental implant placement.

  5. Terminal phalangeal accessory ossification center of the thumb: an additional radiographic finding in Larsen syndrome

    Larsen syndrome is an autosomal-dominant disorder characterized by multiple joint dislocations, vertebral anomalies and dysmorphic facies. Both autosomal-dominant and autosomal-recessive forms of the disorder have been proposed. Individuals with autosomal-dominant Larsen syndrome have characteristic ''cylindrical-shape'' thumbs caused by broad, shortened phalanges. Autosomal-dominant Larsen syndrome results from heterozygosity for mutations in filamin B, a cytoskeletal protein involved in multicellular processes. We report here a patient with a duplicated or accessory distal thumb phalanx and multiple large joint dislocations who was shown to be heterozygous for a filamin B mutation predicting the amino acid substitution G1691S. This adds a new radiographic finding, duplicated or accessory distal phalanx, to the radiographic abnormalities seen in this rare dominant disorder. (orig.)

  6. Accessory belly of piriformis, as a cause of superior gluteal neurovascular entrapment

    Rimple Bansal

    2013-06-01

    Full Text Available During routine dissection on 50 years old male cadaver, an accessory belly of piriformis was observed. This accessory belly was superior and parallel to the main piriformis muscle. This was associated with emergence of superior gluteal nerve and superior gluteal artery between the two bellies. Piriformis muscle and its relation to sciatic nerve has been suggested as a cause of piriformis syndrome. But interestingly in the present case, superior gluteal nerve was interposed between two bellies that may help the clinicians to establish a rare yet important cause of piriformis syndrome and a rare cause of undiagnosed chronic pain in gluteal region. As superior gluteal artery was also interposed, so this rare variation holds interest to surgeons especially in isolated buttock claudication despite otherwise normal vascular investigations. [Int J Res Med Sci 2013; 1(3.000: 296-298

  7. Endovascular glue embolization of dissecting aneurysm of type-3 accessory middle cerebral artery: A contralateral approach.

    Parthasarathy, Rajsrinivas; Goel, Gaurav; Gupta, Vipul; Narang, Karanjit Singh; Anand, Saurabh; Jha, Ajaya Nand

    2015-12-01

    Pediatric intracranial aneurysms are rare with a reported prevalence of 0.5-4.6%. Likewise, anomalous arterial patterns are uncommon in the cerebral circulation. Recognition of these variations and knowledge of vascular territory forms the key to managing pathological conditions associated with these anomalous vessels. Ruptured dissecting aneurysm of type-3 accessory middle cerebral artery (aMCA) has not been reported in the pediatric age group. In addition to type-3 aMCA, the child in this case report had an ipsilateral type-1 aMCA with cortical supply. We describe the patterns of accessory MCA and their vascular territory, state the perplexity involved in deciding the best management strategy, and describe the technical approach we undertook to catheterize this small caliber recurrent artery (type-3 aMCA) originating at an acute angle from the anterior cerebral artery. PMID:26508091

  8. Differentiation and accumulation of fluids in A-type granites: Evidence from accessory mineral study

    2000-01-01

    The Laoshan A-type granite is a highly evolved granite body. The study on accessory minerals indicates that there exist differentiation and accumulation of fluids during the late stage of evolution of the granite. The released fluids are rich in rare-earth elements (REE),high-field- strength elements (HFSE,such as Nb,Ta,Zr,Hf,Th,U,and Y) and volatiles (F,P,CO2,etc.). Owing to the presence of fluid,accessory mineral assemblages have changed during the evolution of A-type granite,and are especially characterized by large amounts of independent REE-Nb-Y-Th minerals present in the late facies. Late-accumulation of fluids may be of the general feature of A-type granites,at least of highly evolved ones.

  9. Sclerotic fibroma (storiform collagenoma)-like stroma in a fibroadenoma of axillary accessory breast tissue.

    Val-Bernal, José Fernando; González-Vela, María Carmen; De Grado, Mauricio; Garijo, María Francisca

    2012-08-01

    Accessory breast tissue is a subcutaneous remnant persisting after normal embryological development of the breast. It occurs most frequently in the axilla. Fibroadenomas in axillary breast tissue are rare. We report the case of a 29-year-old female patient who presented a fibroadenoma arising in the accessory breast tissue of the right axillary fossa. The neoplasm showed foci of sclerotic fibroma-like stroma. The patient had no signs of Cowden's syndrome. To the best of our knowledge, a lesion of this kind has not been previously reported. This stromal change suggests an uncommon involutional phase of the fibroadenoma with production of sclerotic and hypocellular collagen. The lesion should be differentiated from extraneural perineuroma, from the changes in fibroadenomas in Cowden's syndrome, from sclerosing lobular hyperplasia (fibroadenomatoid mastopathy) and from pseudoangiomatous stromal hyperplasia. PMID:22804110

  10. Study on reduction of accessory horsepower requirements. Fourth quarterly progress report

    1975-07-30

    The program objective is to evolve and define an accessory drive system that will minimize system power consumption of driven accessories on an internal combustion engine in a passenger automobile. The initial three program phases established concept feasibility, determined potential fuel savings, and selected a drive system design for concept mechanization. During this quarter the major program accomplishments were: selection of candidate belt-drive concepts; completion of Phase III baseline vehicle drive systems physical and operational envelopes; completion of analysis for a mechanically controlled direct-operated belt drive with input programming; and completion of design layout and analysis for a hydromechanically controlled, servo-operated belt drive with output-speed sensing. (LLL)

  11. Physician accessories: Doctor, what you carry is every patient′s worry?

    Pandey Anita

    2010-10-01

    Full Text Available Background: Nosocomial infections are on the rise worldwide and many a times they are carried by the health care personnel. Accessories used by physicians and healthcare personnel can be a potential source of nosocomial infection. Materials and Methods: We designed a survey with the aim to investigate the prevalence of microbial flora of accessories such as pens, stethoscopes, cell phones and white coat used by the physicians working in a tertiary care hospital. Observations: It was observed that 66% of the pens, 55% of the stethoscopes, 47.61% of the cell phones and 28.46% of the white coats used by the doctors were colonized with various microorganisms. Staphylococcus spp. was the predominant isolate followed by Escherichia coli. Methicillin resistance in Staphylococcus aureus was also found, which was a matter of concern. Conclusions: Awareness of appropriate hand hygiene is important in order to prevent potential transmission to patients.

  12. Magnetocardiographic non-invasive localization of accessory pathways in the Wolff-Parkinson-White syndrome by a multichannel system.

    Weismüller, P; Abraham-Fuchs, K; Schneider, S; Richter, P; Kochs, M; Hombach, V

    1992-05-01

    Electrical activity can be localized by magnetocardiography (MCG) non-invasively. In this study a 37-SQUID (Super Conducting Quantum Interference Device) sensor multi-channel system (KRENIKON) was used to assess the potential of magnetocardiography to localize accessory pathways with a multichannel system. Seven WPW patients were studied by means of magnetocardiography. Prior to the MCG recordings, the site of the accessory pathway had been determined in all patients by invasive catheter mapping. MR images of the heart were used for anatomical correlation. The magnetocardiographic localization of the accessory pathway corresponded with catheter mapping within 2.1 cm on average (total range: 0-5 cm). This is thus, a promising new method for non-invasive localization of accessory pathways in WPW patients. PMID:1618202

  13. Finding an Export Market for a Small Finnish Boating Accessories Web-Shop : A case study

    Nylund, Thomas

    2015-01-01

    Technological developments and regional integration have increased the amount of inter-national business transactions. Organizations of all sizes now have a possibility to take advantage of international business opportunities. By internationalizing firms can find new sources of growth and innovation, and escape unfavorable home market conditions. This thesis is an empirical study of potential export markets. The thesis is a case study of a small Finnish boating accessories web-shop. The thes...

  14. An unusual presentation of whiplash injury: long thoracic and spinal accessory nerve injury

    N. Omar; Alvi, F.; M. S. Srinivasan

    2007-01-01

    Whiplash injuries from motor vehicle accidents are very common. The usual presentation and course of this condition normally results in resolution of symptoms within a few weeks. Brachial plexus traction injuries without any bone or joint lesion of the cervical spine have been reported before. We report a case where a gentleman was involved in a rear end vehicle collision, sustained a whiplash injury and was later found to have a long thoracic nerve palsy and spinal accessory nerve palsy. Alt...

  15. Atrial flutter in the fetus and young infant: an association with accessory connections.

    Till, J; WREN, C.

    1992-01-01

    OBJECTIVE--To highlight the association between atrial flutter and accessory connections in the fetus and young infant. DESIGN--A retrospective review from January 1985 to January 1990. PATIENTS--Fetuses, neonates, and young infants with atrial flutter. RESULTS--Four fetuses and five infants presented with atrial flutter. In two fetuses and one infant sinus rhythm returned spontaneously. The other six required cardioversion. Three of them developed orthodromic atrioventricular re-entry tachyc...

  16. Partial restoration of blink reflex function after spinal accessory-facial nerve anastomosis.

    Danziger, N; Chassande, B; Lamas, G.; Fligny, I; Soudant, J; Willer, J C

    1995-01-01

    Functional motor control requires perfect matching of the central connections of motoneurons with their peripheral inputs. It is not known, however, to what extent these central circuits are influenced by target muscles, either during development or after a lesion. Surgical interventions aimed at restoring function after peripheral nerve lesions provide an opportunity for studying this interaction in the mature human nervous system. A patient was studied in whom the spinal accessory nerve was...

  17. Sexual activity increases the number of newborn cells in the accessory olfactory bulb of male rats

    Portillo, Wendy; Unda, Nancy; Camacho, Francisco J.; Sánchez, María; Corona, Rebeca; Arzate, Dulce Ma.; Díaz, Néstor F.; Paredes, Raúl G.

    2012-01-01

    In rodents, sexual behavior depends on the adequate detection of sexually relevant stimuli. The olfactory bulb (OB) is a region of the adult mammalian brain undergoing constant cell renewal by continuous integration of new granular and periglomerular neurons in the accessory (AOB) and main (MOB) olfactory bulbs. The proliferation, migration, survival, maturation, and integration of these new cells to the OB depend on the stimulus that the subjects received. We have previously shown that 15 da...

  18. Sexual activity increases the number of newborn cells in the accessory olfactory bulb of male rats.

    Wendy Portillo; Díaz, Néstor F.

    2012-01-01

    In rodents, sexual behavior depends on the adequate detection of sexually relevant stimuli. The olfactory bulb (OB) is a region of the adult mammalian brain undergoing constant cell renewal by continuous integration of new granular and periglomerular neurons in the accessory (AOB) and main (MOB) olfactory bulbs. The proliferation, migration, survival, maturation, and integration of these new cells to the OB depend on the stimulus that the subjects received. We have previously shown that 15 da...

  19. Hybrid vehicle powertrain system with power take-off driven vehicle accessory

    Beaty, Kevin D.; Bockelmann, Thomas R.; Zou, Zhanijang; Hope, Mark E.; Kang, Xiaosong; Carpenter, Jeffrey L.

    2006-09-12

    A hybrid vehicle powertrain system includes a first prime mover, a first prime mover driven power transmission mechanism having a power take-off adapted to drive a vehicle accessory, and a second prime mover. The second prime mover is operable to drive the power transmission mechanism alone or in combination with the first prime mover to provide power to the power take-off through the power transmission mechanism. The invention further includes methods for operating a hybrid vehicle powertrain system.

  20. Brachymetatarsia with accessory navicular in right foot: A rare coincidental finding

    Pandey, Praveen Kumar; Pawar, Inder; Beniwal, Sandeep Kumar; Verma, Raaghav R.

    2016-01-01

    A 33 years old female patient presented with posttraumatic pain in the right foot for which radiographs of the right foot was advised. No fracture was detected on radiographs and patient was managed conservatively on medications and posterior splint immobilization. We found coincidentally a short fourth metatarsal and an accessory navicular bone in the right foot radiographs. After 3 weeks of immobilization, she underwent mobilization of the right foot, weight bearing and intensive physiother...