Although clinic environments are a primary location for exchanging information with clinicians, patients experience these spaces as harsh environments to access, use, exchange, and manage information....Full Text Available
Background Stimulated by the concept of Natural Orifice Transluminal Endoscopic Surgery (NOTES), minimizing the access even further has become a new trend in minimally invasive surgery. We compare our recently described new method of endoscopic single-access adrenalectomy with the conventional retroperitoneoscopic approach in a matched-pairs study. Methods Fifty single-access retroperitoneoscopic adrenalectomies (SARA) were performed in 47 selected patients suffering from Conn?s adenomas (n?=?20), pheochromocytomas (n?=?15), Cushing?s adenomas (n?=?6), and other diseases (n?=?6). For SARA, a single 2-cm skin incision beneath the 12th rib was used. Following creation of the retroperitoneal space with the rigid endoscope, dissection was carried out single-handed. Another 47 patients served a...
Exponentially growing biological and bioinformatics data sets present a challenge and an opportunity for researchers to contribute to the understanding of the genetic basis of phenotypes. Due to breakthroughs in microarray technology, it is possible to simultaneously monitor the expressions of thousands of genes, and it is imperative that researchers have access to the clinical data to understand the genetics and proteomics of the diseased tissue. This technology could be a landmark in personalized medicine, which will provide storage for clinical and genetic data in electronic health records (EHRs). In this paper, we explore the computational and ethical challenges that emanate from the intersection of bioinformatics and healthcare informatics research. We describe the current situation of the EHR and its capabilities to store clinical and genetic data and then discuss the Genetic Information Nondiscrimination Act. Finally, we posit that the ...
In both office and home environments, Ethernet represents the dominant networking technology in use. Ethernet is low cost and the networks are fairly understood by users. The author began by explaining the physical and data link layers of Ethernet, then touched on fibre-optic cables. The industrial protocols were discussed, followed by Ethernet network topology. The environmental robustness of Ethernet networks was reviewed, with a word of caution from the author, advising to properly evaluate whether Ethernet represents a mission-critical component of the substation, as substation control houses are not environmentally controlled spaces, often minimally heated and no cooling. Engineering access to station Integrated Electric Drives (IEDs). By properly connecting Ethernet networks, it is possible to access relays in the substations from desktop engineering workstations in the central office. Network security issues must be ...
Purpose - The purpose of this paper is to encourage other libraries to provide access to their own original content via the web. By way of case study, the process of identifying materials, scanning them and creating web access to original content will be explored. Design/methodology/approach - To implement a book digitization project, three major things need to be present. The library must own material that was published prior to 1923, making them safely out of copyright in the USA; the library needs access to server space on the web and the library needs to own scanning equipment. Findings - This project demonstrated that a library does not necessarily need to obtain grant funding to begin an effective and successful digitization program. It also revealed a few things that would improve t...
Infinite loop space theory, both additive and multiplicative, arose largely from two basic motivations. One was to solve calculational questions in geometric topology. The other was to better understand algebraic K-theory. The Adams conjecture is intrinsic to the first motivation, and Quillen's proof of that led directly to his original, calculationally accessible, definition of algebraic K-theory. In turn, the infinite loop understanding of algebraic K-theory feeds back into the calculational questions in geometric topology. For example, use of infinite loop space theory leads to a method for determining the characteristic classes for topological bundles (at odd primes) in terms of the cohomology of finite groups. We explain just a little about how all that works, focusing on the central role played by E infinity ring spaces.
The heavy neutral Higgs bosons H, A in the minimal supersymmetric extension of the standard model can be produced as single resonances at high-energy #gamma##gamma# colliders. We have studied the prospects of the search for these particles in bb and neutralino-pair final states. The Higgs bosons can be found with masses up to 70-80% of the initial e"#+-#e"- collider energy for medium values of tg#beta#, i.e. in areas of the supersymmetric parameter space not accessible at other colliders. (orig.)
The heavy Higgs bosons H,A of the minimal supersymmetric extension of the Standard Model can be produced as resonances in high-energy #gamma##gamma# colliders. Prospects of the search for these particles in bb-bar and neutralino-pair final states are studied in this report. Heavy Higgs bosons can be found with masses up to about 70-80% of the initial e"+e"- collider energy for moderate values of tan #beta#, i.e. in areas of the parameter space not accessible at other colliders.
Future #gamma##gamma# colliders allow the production of the heavy neutral MSSM Higgs bosons H and A as single resonances. The prospects of finding these particles in the bb-bar and the neutralino-pair final states have been analyzed. The H, A bosons can be discovered for medium values of tan #beta# with masses up to 70-80% of the initial e"#+-#e"- c.m. energy. This production mode thus covers parts of the supersymmetric parameter space that are not accessible at other colliders.
A length of metal sheathed metal oxide cable is perforated to permit liquid access to the insulation about a pair of conductors spaced close to one another. Changes in resistance across the conductors will be a function of liquid level, since the wetted insulation will have greater electrical conductivity than that of the dry insulation above the liquid elevation.
Individual strains of the plant pathogenic bacterium Pseudomonas syringae vary in their ability to produce toxins, nucleate ice, and resist antimicrobial compounds. These phenotypes...Full Text Available
Upcoming high-intensity laser systems will be able to probe the quantum-induced nonlinear regime of electrodynamics. So far unobserved QED phenomena such as the discovery of a nonlinear response of the quantum vacuum to macroscopic electromagnetic fields can become accessible. In addition, such laser systems provide for a flexible tool for investigating fundamental physics. Primary goals consist in verifying so far unobserved QED phenomena. Moreover, strong-field experiments can search for new light but weakly interacting degrees of freedom and are thus complementary to accelerator-driven experiments. I review recent developments in this field, focusing on photon experiments in strong electromagnetic fields. The interaction of particle-physics candidates with photons and external fields can be parameterized by low-energy effective actions and typically predict characteristic optical signatures. I perform first estimates of the accessible ...
The PSDE/SAT-2 multimission satellite designed to offer a flight opportunity to different experimental communication payloads and verify the feasibility of advanced space technologies is described. It was conceived for expriment in the framework of the European DRS (Data Relay Satellite) program thus providing intersatellite and interorbit communication links, but also experimental and preoperative services. Payloads include optical communication single access payload (LSA); S-Band single access payload; S-Band multiple access payload; land mobile experimental payload; navigation payload; 40/50 GHz communication payload; and millimeter wave propagation payload. The orbital slot and interference analysis identified a limited number of orbital positions for the mission interleaved between Eutelsat satellites (i.e., 14 deg 30 min E and 17 deg 30 min E). A coordination is required in Ku-Band with Eutelsat ...
The heavy Higgs bosons H,A of the minimal supersymmetric extension of the Standard Model can be produced as resonances in high-energy {gamma}{gamma} colliders. Prospects of the search for these particles in bb-bar and neutralino-pair final states are studied in this report. Heavy Higgs bosons can be found with masses up to about 70-80% of the initial e{sup +}e{sup -} collider energy for moderate values of tan {beta}, i.e. in areas of the parameter space not accessible at other colliders.
The heavy neutral Higgs bosons H, A in the minimal supersymmetric extension of the standard model can be produced as single resonances at high-energy {gamma}{gamma} colliders. We have studied the prospects of the search for these particles in bb and neutralino-pair final states. The Higgs bosons can be found with masses up to 70-80% of the initial e{sup {+-}}e{sup -} collider energy for medium values of tg{beta}, i.e. in areas of the supersymmetric parameter space not accessible at other colliders. (orig.)
The R&D in satellite communications in Korea has been driven mainly by KCC (Korea Communications Commission) but in a small scale compared to Korea space development program organized by MEST (Ministry of Education, Science and Technology). Public and civilian satcom sector R&D has been led mainly by ETRI with small/medium companies contrary to rare investment in private sector while military sector R&D has been orchestrated by ADD with defense industry. By the COMS (Communication, Ocean and Meteorological Satellite) experimental Ka-band payload, Korea pursues a space qualification of own technology for national infrastructure evolution as well as industrialization of space R&D results. Once COMS launched and space qualified in 2009, subsequent application experiments and new technology R&D like UHDTV will entail service and industry promotion. The payload technology is expected for ...
The DataAccessBean is similar to the Data Access Object (DAO) interface in that the DataAccessBean interface is meant to encapsulate the implementation details of the DynamicJavaBean that accesses persistent storage devices such as RDBMS, flat text file databases, etc.
Whereas genetic factors are known to influence both susceptibility to carcinogens and the capacity to respond to specific antigenic stimuli, little is known regarding the influence of phenotype per...Full Text Available
The flacca tomato (Lycopersicon esculentum) mutant displays a wilty phenotype as a result of abscisic acid (ABA) deficiency. The Mo cofactor (MoCo)-containing aldehyde...Full Text Available
Developing in vitro engineered hepatic tissues that exhibit stable phenotype is a major challenge in the field of hepatic tissue engineering. However, the rapid dedifferentiation of...Full Text Available
Spontaneous and ultraviolet-induced changeabilities of wine yeasts from the killer state to sensitive one have been studied. Observed often spontaneous changes of killer and neutral phenotypes under laboratory store conditions as well as high mutation frequency of genetic elements responsible for the killer indication on ultraviolet irradiation testify that often encounterability in nature and in the production of sensitive yeasts is attributed to high frequency of mutation changes of the killer and neutral phenotypes to the sensitive state.
This paper consists the radiation streaming analysis of Horizontal Flux Unit (HFU) penetrations in Calandria Vault of 540 MWe PHWR. There are total 7 HFU penetrations on west wall of calandria vault. As these penetrations are in accessible area, a detailed analysis has been carried out to find the neutron and gamma dose rates around these penetrations when reactor is operating. Analysis has been carried out Using the computer code MCNP and DOT-III. Based on the predictions at HFU penetrations, shielding arrangement was recommended. Neutron and gamma dose rate higher than estimated were observed at TAPS-4. This was because of installed shield not being similar to recommended one due to site conditions. Subsequently semi-empirical calculations using measured data were carried out by MCNP to further augment the existing shield taking into consideration the space limitations at site. (author)
Remote, offshore gas reserves have long been a challenging deepwater petroleum resource to tap. Natural gas in many offshore regions is plentiful, but lacks access to the market because of the logistical challenges and costs. Most large offshore gas discoveries are capped, and gas associated with oil production is re-injected into the reservoir or is flared. A more attractive option is to convert the gas into a liquid product on a floating production, storage, and offloading (FPSO) vessel. However, some conventional process technologies are not well suited for operation on floating vessels that are highly space and weight constrained and may challenge vessel stability during inclement weather. Microchannel process technology units under development offer intensified processes that are suit...
We study dipolar bosons in a 1D optical lattice and identify a region in parameter space---strong coupling but relatively weak on-site repulsion---hosting a series of stable CDW states whose low-energy excitations, built from "fractional domain walls", are remarkably similar to those of non-abelian fractional quantum Hall states. Here, a conventional domain wall between translated CDW's may split by inserting strings of degenerate, but inequivalent, CDW states. Outside these insulating regions, we find numerous supersolids as well as a superfluid regime. The mentioned phases should be accessible experimentally, and in particular, the fractional domain walls can be created in the ground state using single-site addressing, i.e. by locally changing the chemical potential.
The optically stimulated luminescent (OSL) radiation dosimeter technically surveys a wide dynamic measurement range and a high sensitivity. Optical fiber dosimeters provide capability for remote monitoring of the radiation in the locations which are difficult-to-access and hazardous. In addition, optical fiber dosimeters are immune to electrical and radio-frequency interference. In this paper, a novel remote optical fiber radiation dosimeter is described. The optical fiber dosimeter takes advantage of the charge trapping materials CaS:Ce, Sm that exhibit OSL. The measuring range of the dosimeter is from 0.1 to 100 Gy. The equipment is relatively simple and small in size, and has low power consumption. This device is suitable for measuring the space radiation dose and also can be used in high radiation dose condition and other dangerous radiation occasions. (authors)
Lentiviral vectors (LVs) have emerged as potent and versatile vectors for ex vivo or in vivo gene transfer into dividing and nondividing cells. Robust phenotypic correction...Full Text Available
Synthetic polymers and nanomaterials display selective phenotypic effects in cells and in the body that affect signal transduction mechanisms involved in inflammation, differentiation, proliferation,...Full Text Available
... growth hormone-like factor from plerocercoids of the tapeworm Spirometra mansonoides is a multifunctional protein. In Parasites and pathogens: ... ...
BackgroundRecent studies have shown associations between size and body proportions at birth and health outcomes throughout the life cycle, but there are few data...Full Text Available
Purpose.There is a paucity of neuron replacement studies for retinal ganglion cells. Given the complex phenotype of these neurons, replacement of ganglion cells may be impossible....Full Text Available
In natural ecosystems, hundreds of species typically share the same environment and are connected by a dense network of interactions such as predation or competition for resources. Much is known about...Full Text Available
Mutations in the Drosophila gene drop-dead (drd) result in early adult lethality and neurodegeneration, but the molecular identity of the drd...Full Text Available
We report the isolation of adherent, clonogenic, fibroblast-like cells with osteogenic and adipogenic potential from the blood of four mammalian species. These cells phenotypically resemble but are...Full Text Available
Transparency is essential for normal corneal function. Recent studies suggest that corneal cells express high levels of so-called corneal crystallins, such as aldehyde dehydrogenase (ALDH) and transketolase (TKT) that contribute to maintaining cellular transparency. Stromal injury leads to the appearance of repair phenotype keratocytes, the corneal fibroblast and myofibroblast. Previous studies on keratocytes from species such as bovine and rabbit indicate that the transformation from the normal to repair phenotype is accompanied by a loss of corneal crystallin expression, which may be associated with loss of cellular transparency. Here we investigated if a similar loss occurs with human keratocyte repair phenotypes. Human corneal epithelial cells were collected by scraping and keratocytes...
Several scientists have proposed that DNA repair deficiencies and the induction of a mutator phenotype are responsible for the generation of multiple mutagenic alterations in cancer cells. I propose...Full Text Available
The complete nucleotide sequence of the cap3A gene of Streptococcus pneumoniae, which is directly responsible for the transformation of some unencapsulated, serotype 3 mutants to the encapsulated phenotype,...Full Text Available
Long-term heat acclimation (AC, 30d/34°C) is a phenotypic adaptation leading to increased thermotolerance during heat stress (HS, 2 h 41°C). AC also renders protection against...Full Text Available
IntroductionThe phenotypic and functional differences between cells that initiate human breast tumors (cancer stem cells) and those that comprise the tumor bulk are difficult to...Full Text Available
G6PD activity was assayed in 20 Sardinian heterozygotes for G6PD deficiency and related to that of LDH and MDH. One of these heterozygotes showed a deficient phenotype in all her follicles, while the...Full Text Available
Four new mutants are described whose phenotypic expression affects the length of the head of bacteriophage T4D. All mutants produce some phenotypically normal phage particles. Mutant pt21-34...Full Text Available
Purpose: This preliminary report describes the development and implementation of a project to improve access to literature in Latin American social medicine (LASM).Methods:...Full Text Available
The main problems arising in decommissioning nuclear-powered submarines (NPS) relate to choosing a concept of handling reactor compartments followed by handling technology development. Reactor compartments (RC) are characterized with extremely space-saving or integral layout of large-size power equipment and systems, restricted access for dismantling, high radiation dose rates in a number of bays of RC. The above RC features pose a problem to find optimum option of RC utilization which on the one hand would be the most cost efficient, and the safest as possible on the other, i.e. dose commitments of personnel involved should be minimum, and effect on population and environment should be negligible. The main radiation factors specifying safety in RC handling at any decommissioning stage are as follows: (1) total radioactivity integrated in reactor facility (RF); (2) distribution of this radioactivity through RF equipment and structures; (3) ...
The Heavy Water Reactor Facility (HWRF), as part of the defense-in-depth philosophy to mitigate the effect of design-basis and severe accidents, is equipped with a passive containment cooling system (PCCS). The function of the PCCS is to provide a safety-grade path to the ultimate heat sink for the removal of the reactor coolant system sensible heat and core decay heat. Ambient air enters an annular space between the steel containment shell and the surrounding concrete shield building through inlets in the shield building wall, is heated via natural convection, rises, and exits the building through a chimney located above the containment dome. A test program is in place to access parameters important to the effective operation of the PCCS. This paper focuses on the large-scale tests (LSTs). The objectives of these tests are as follows: (1) demonstrate natural circulation cooling with more prototypic cylinder and dome surface area ratios than ...
The Heavy Water Reactor Facility (HWRF), as part of the defense-in-depth philosophy to mitigate the effect of design-basis and severe accidents, is equipped with a passive containment cooling system (PCCS). The function of the PCCS is to provide a safety-grade path to the ultimate heat sink for the removal of the reactor coolant system sensible heat and core decay heat. Ambient air enters an annular space between the steel containment shell and the surrounding concrete shield building through inlets in the shield building wall, is heated via natural convection, rises, and exits the building through a chimney located above the containment dome. A test program is in place to access parameters important to the effective operation of the PCCS. This paper focuses on the large-scale tests (LSTs). The objectives of these tests are as follows: (1) demonstrate natural circulation cooling with more prototypic cylinder and dome surface area ratios than ...
We will report on a new type of tunable semiconductor laser, which is based on the electronic selection of one Bragg grating among an array of such gratings in silica. The device that we have built operates at 120 Mb/s but extension to 1 Gb/s for Gigabit-Ethernet applications would be straightforward. In comparison with tunable semiconductor lasers using gratings in the III-V materials, silica gratings offer two significant advantages: 1-wavelength stability and predictability, 2-the ability to phusically overlap many gratings in a compact space in order to enable the selection of a large number of wavelengths for wavelength division multiplexed communications systems. The time required to chagne the wavelength in our laser has not been measured for lack of the necessary electronics but it is expected to be in the microsecond range on the basis of a straightforward calculation. The robust all solid-state nature of our device and its expected microsecond ...
The paper describes a concept of extracting fusion power from D-{sup 3}He fueled IEC (Inertia Electrostatic Configuration) devices. The fusion system consists of a series of fusion modules and direct energy converters at an end or at both ends. This system of multiple units is linear and is connected by a magnetic field. A pair of coils anti-parallel to the magnetic field yields a field-null domain at the center of each unit as required for IEC operation. A stabilizing coil installed between the coil pairs eliminates the strong attractive force between the anti-parallel coils. Accessible regions for charged particle trajectories are essentially isolated from the coil structure. Thus, charged particles are directed along magnetic field lines to the direct energy converter without appreciable losses. A direct energy converter unit designed to be compatible to this unique system is also described. It basically consists of a separator and a traveling wave converter. A ...
The optically stimulated luminescent (OSL) radiation dosimeter technically surveys a wide dynamic measurement range and a high sensitivity. Optical fiber dosimeters provide capability for remote monitoring of the radiation in the locations which are difficult-to-access and hazardous. In addition, optical fiber dosimeters are immune to electrical and radio-frequency interference. In this paper, a novel remote optical fiber radiation dosimeter is described. The optical fiber dosimeter takes advantage of the charge trapping materials CaS:Ce, Sm that exhibit OSL. The measuring range of the dosimeter is from 0.1 to 100 Gy. The equipment is relatively simple and small in size, and has low power consumption. This device is suitable for measuring the space radiation dose and also can be used in high radiation dose condition and other dangerous radiation occasions. Supported by National Natural Science Foundation of China (10475112), Western Light ...
There are 760 feederpipes, which they are connected to inlet/outlet of the 380 pressure tube channels on the front of the calandria, in CANDU-type Reactor of Wolsung Nuclear Power Plant. As an ISI(In-Service Inspection) and PSI (Post-Service Inspection) requirements, maintenance activities of measuring the thickness of curvilinear part of feederpipe and inspecting the feederpipe support area within calandria are needed to ensure continued reliable operation of nuclear power plant. And ultrasonic probe is used to measure the thickness of curvilinear part of feederpipe, however workers are exposed to radioactivity irradiation during the measurement period. But, it is exposed to radioactivity irradiation during the measurement period. But, it is impossible to inspect feederpipe support area thoroughly because of narrow and confined accessibility, that is , an inspection space between the pressure tube channels is less than 100 mm and pipes in ...
There are 760 feederpipes, which they are connected to inlet/outlet of the 380 pressure tube channels on the front of the calandria, in CANDU-type Reactor of Wolsung Nuclear Power Plant. As an ISI(In-Service Inspection) and PSI (Post- Service Inspection) requirements, maintenance activities of measuring the thickness of curvilinear part of feederpipe and inspecting the feederpipe support area within calandria are needed to ensure continued reliable operation of nuclear power plant. And untrasonic probe is used to measure the thickness of curvilinear part of feederpipe, however workers are exposed to radioactivity irradiation during the measurement period. But, it is impossible to inspect feederpipe support area thoroughlv because of narrow and confined accessibility, that is, an inspection space between the pressure tube channels is less than 100mm and pipes in feederpipe support area are congested. And also, workers involved in inspecting ...
Apr 22, 2010 ... I believe that space exploration is not a ... plan for space exploration, especially in .... space exploration beyond low Earth orbit. ...
...Observatory Edinburgh SkyView Virtual Observatory Solar System Simulator Space Telescope Science Institute Space Weather : A Research Perspective Subaru Telescope Project Two Micron All ...Universities for Research in Astronomy Subjects: space observation DeweyClass: 522 Resource type: index Space Weather : A Research Perspective Documents discussing space weather , the ...elements of near-Earth space, Earth-space meteorology and practical consequences of space weather . Glossary included. Author: National Academy of ...
Good performance in extended lactations of dairy cattle may have a beneficial effect on food costs, health, and fertility. Because data for extended lactation performance is scarce, lactation persistency has been suggested as a suitable selection criterion. Persistency phenotypes were calculated in several ways: P1 was yield relative to an approximate peak, P2 was the slope after peak production, and P3 was a measure derived to be phenotypically uncorrelated to yield and calculated as a function of linear regressions on test-day deviations of days in milk. Phenotypes P1, P2, and P3 were calculated for sires as solutions estimated from a random regression model fitted to milk yield. Because total milk yield, calculated as the sum of daily sire solutions, was correlated to P1 and P2 (r=0.30 ...
This report describes a technique of inserting an implantable venous access port (portacath) through a thrombosed and occluded vein employing a pre-existing peripherally inserted central catheter (PICC) as the route of access. The PICC was used as a conduit for venous access in a way that has not been described previously in the literature. This procedure was performed in a young patient with cystic fibrosis in an effort to prevent the use of his virgin contralateral veins, which might be used in the future.
Steam generators for nuclear plants require access to the primary and secondary side for various inspection, cleaning and repair procedures and upon achieving access various inspection and cleaning tasks must be carried out. Steam generators currently at manufacture are therefore provided with; primary side access via the primary manways, steam drum access via the steam drum manway, U-bend region access via the secondary manway and drum-internals access passages, tubesheet secondary side access via tubesheet level inspection ports and tube support plate access via tube support level access ports. Many CANDU steam generators were built with only primary and drum manways and either no tubesheet ports or ports which were located ineffectively. The steam generators at Wolsong 1 were built with secondary ...
The need for a Combustion and Melting Research Facility focused on the solution of glass manufacturing problems common to all segments of the glass industry was given high priority in the earliest version of the Glass Industry Technology Roadmap (Eisenhauer et al., 1997). Visteon Glass Systems and, later, PPG Industries proposed to meet this requirement, in partnership with the DOE/OIT Glass Program and Sandia National Laboratories, by designing and building a research furnace equipped with state-of-the-art diagnostics in the DOE Combustion Research Facility located at the Sandia site in Livermore, CA. Input on the configuration and objectives of the facility was sought from the entire industry by a variety of routes: (1) through a survey distributed to industry leaders by GMIC, (2) by conducting an open workshop following the OIT Glass Industry Project Review in September 1999, (3) from discussions with numerous glass engineers, scientists, and executives, and (4) during visits to ...
To develop a work in an area with high radiation, it requires of a detailed knowledge of the surroundings work, a communication and effective vision, a near dosimetric control. In a work where the spaces variables and reduced accesses exist, noise that hinders the communication, defendant operative condition, radiation field and taking of decision, it is necessary to have tools that allow a total control of the environment to make opportune and effective decisions, there where the task is developed. Under this elementary concept, it was developed in the Laguna Verde Central a project that it allowed a mechanism, interactive of control in spaces complex; to see, to hear, to speak, to measure. This concept takes to the creation of an equipped system with closed circuit of television, wireless communication systems, tele dosimetry wireless systems, VHS and DVD recording equipment, uninterrupted energy units. The system ...
...Section 508 and Electronic Information Technology Accessibility at EPA | US EPA Jump to main content. Section 508 and Electronic Information Technology ...Us Search: All EPA Advanced search You are here: EPA Home Section 508 and Electronic Information Technology Accessibility at EPA Welcome to the United ... Section 508 of the Rehabilitation Act mandates that Federal departments and agencies make electronic and information technology (EIT) accessible to individuals ... Achieving compliance with Section 508 is an ongoing process. If you have any problems or questions about accessing information on a particular ...
Purpose.To evaluate morphologic and functional contributions of Arrestin 1 (Arr1) and Arrestin 4 (Arr4) in cone photoreceptors, the authors examined the phenotypes of visual arrestin...Full Text Available
Extending genome wide association analysis by the inclusion of gene expression data may assist in the dissection of complex traits. We examined piebald, a pigmentation phenotype in both human and Merino...Full Text Available
Molecular Misreading (MM) is the inaccurate conversion of genomic information into aberrant proteins. For example, when RNA polymerase II transcribes a GAGAG motif it synthesizes at low frequency RNA...Full Text Available
Synthetic gene networks can be used to control gene expression and cellular phenotypes in a variety of applications. In many instances, however, such networks can behave unreliably due to gene expression...Full Text Available
In addition to the well documented role of cytokines in mediating tissue-level interactions, it is now clear that matrix macromolecules fulfil a complementary regulatory function. Data highlighted in...Full Text Available
Materials and MethodsThe genomic effects of tumor-endothelial interactions in cancer are not yet well characterized. To study this interaction in breast...Full Text Available
BackgroundPerichondrium is recognized as a tissue with chondrogenic potential yielding cells which can be used for osteochondral repair. Factors which influence the proliferative...Full Text Available
Depleted uranium (DU) is a dense heavy metal used primarily in military applications. Although the health effects of occupational uranium exposure are well known, limited data exist regarding the long-term...Full Text Available
Eukaryotic genome size varies over five orders of magnitude; however, the distribution is strongly skewed toward small values. Genome size is highly correlated to a number of phenotypic traits, suggesting...Full Text Available
PurposeTo date there remains no effective therapy for metastatic melanoma and at the molecular level disease progression remains poorly understood. Recent work by...Full Text Available
BackgroundActivation of the signal transducer and activator of transcription 3 (STAT3) within antigen presenting cells (APCs) is linked to abnormal APCs differentiation and function....Full Text Available
The Arabidopsis ref2 mutant was identified in a screen for plants having altered fluorescence under UV light. Characterization of the ref2 mutants showed that they...Full Text Available
Mouse lines with behavioral phenotypes relevant to symptoms in neurodevelopmental disorders may provide models to test hypotheses about disease etiology and to evaluate potential treatments....Full Text Available
The purpose of this study was to determine the occurrence and genotypic relatedness of Salmonella enterica isolates recovered from feed and fecal samples in commercial swine production...Full Text Available
We previously reported that global deletion of insulin receptor substrate protein 1 (Irs1) extends lifespan and increases resistance to several age-related pathologies in female mice....Full Text Available
Genomic disorders are conditions that result from DNA rearrangements, such as deletions or duplications. The identification of the dosage-sensitive gene(s) within the rearranged genomic interval is...Full Text Available
Successful implementation of bone marrow transplantation for hematopoietic reconstitution is limited by the lack of suitably HLA-matched donors and by the occurrence of graft-versus-host disease that...Full Text Available
Epithelial-mesenchymal transition (EMT) has emerged in recent years as an important process in the development of organ fibrosis in many human diseases. Our previous experience in a nonhuman primate...Full Text Available
... Fluctuating Incubation Temperatures in the Multi-banded Krait, Bungarus multicintus (Elapidae)Xiang Ji1,2,*, Jian-Fang Gao1, ... rather than applying constant-temperature regimes. We incubated Bungarus mu...
Toxicogenomics provides the ability to examine in greater detail the underlying molecular events that precede and accompany toxicity, thus allowing prediction of adverse events at much earlier...Full Text Available
OBJECTIVENicotinamide adenine dinucleotides (NAD+ and NADH) play a crucial role in cellular energy metabolism, and a dysregulated NAD+-to-NADH ratio is implicated...Full Text Available
The epigenome consists of non–sequence-based modifications, such as DNA methylation, that are heritable during cell division and that may affect normal phenotypes and predisposition...Full Text Available
About 20% of adults are persistently colonized with S. aureus in the anterior nares. Host genetic factors could contribute susceptibility to this phenotype. The objective of...Full Text Available
Ever since the pre-molecular era, the birth of new genes with novel functions has been considered to be a major contributor to adaptive evolutionary innovation. Here, I review the origin and evolution...Full Text Available
Objectives:Copy number variants (CNVs) have been recognized as a source of genetic variation that contributes to disease phenotypes. Alzheimer disease (AD) has high heritability...Full Text Available
The imaging analytical capabilities of laser scanning cytometer (LSC) have been used to assess morphological features considered to be typical of the senescent phenotype. The characteristic “flattening”...Full Text Available
BackgroundMutations that impair mitochondrial functioning are associated with a variety of metabolic and age-related disorders. A barrier to rigorous tests of the role of mitochondrial...Full Text Available
Wild-type viruses from the ViroLogic phenotype-genotype database were evaluated to determine the upper confidence limit of the drug susceptibility distributions, or “biological cutoffs,”...Full Text Available
E-cadherin is the primary cell adhesion molecule within the epithelium, and loss of this protein is associated with a more aggressive tumour phenotype and poorer patient prognosis in many cancers. Loss...Full Text Available
Purpose: Small animal micro-CT imaging is being used increasingly in preclinical biomedical research to provide phenotypic descriptions of genomic models. Most of this imaging is coincident...Full Text Available
Epithelial-mesenchymal transition (EMT), a switch of polarized epithelial cells to a migratory, fibroblastoid phenotype, is considered a key process driving tumor cell invasiveness and metastasis....Full Text Available
The development of azole resistance in Candida albicans is most problematic in patients with AIDS who receive long courses of drug for therapy or prevention of oral candidiasis. Recently,...Full Text Available
Insulin resistance in skeletal muscle is a key phenotype associated with type 2 diabetes (T2D) for which the molecular mediators remain unclear. We therefore conducted an expression analysis of human...Full Text Available
Life history theory proposes that early-life cues induce highly integrated responses in traits associated with energy partitioning, maturation, reproduction, and aging such that the individual phenotype...Full Text Available
Stem cells of the human prostate gland have not yet been identified utilizing a structural biomarker. We have discovered a new prostatic epithelial cell phenotype-expressing cytokeratin 6a (Ck6a+...Full Text Available
Hereditary hypouricemia may result from mutations in the renal tubular uric acid transporter URAT1. Whether mutation of other uric acid transporters produces a similar phenotype is unknown. We studied...Full Text Available
The supramammillary nucleus (SuM) provides substantial projections to the hippocampal formation. This hypothalamic structure is involved in the regulation of hippocampal theta rhythm and therefore...Full Text Available
BackgroundSize and body proportions at birth are partly determined by maternal body composition, but most studies of mother-baby relationships have only considered...Full Text Available
Mood and anxiety disorders and rodent phenotypic measures modeling these disorders have a strong genetic component. Various assays are used to study the neurobiological basis of fear- and anxiety-related...Full Text Available
The genetic architecture of complex traits underlying physiology and disease in most organisms remains elusive. We still know little about the number of genes that underlie these traits, the magnitude...Full Text Available
Human blinding disorders are often initiated by hereditary mutations that insult rod and/or cone photoreceptors and cause subsequent cellular death. Generally, the disease phenotype can be predicted...Full Text Available
The murine cytomegalovirus (MCMV) M33 gene is conserved among all betaherpesviruses and encodes a homologue of seven-transmembrane receptors (7TMR) with the capacity for constitutive signaling. Previous...Full Text Available
Gene expression data has been used in lieu of phenotype in both classical and quantitative genetic settings. These two disciplines have separate approaches to measuring and interpreting epistasis, which...Full Text Available
Fluctuating asymmetry (FA) has been widely used as a stress-related phenotypic marker of developmental instability. However, previous studies relating FA to various stressful conditions have produced...Full Text Available
BackgroundNF-κB is a survival signaling transcription factor complex involved in the malignant phenotype of many cancers, including squamous cell carcinomas (SCC). The citrus...Full Text Available
Japanese medaka (Oryzias latipes) embryos exposed to ethanol have developed craniofacial, cardiovascular and skeletal defects which can be compared with the phenotypic features...Full Text Available
Uncoupling protein 2 (UCP2) maps to a region on distal mouse chromosome 7 that has been linked to the phenotypes of obesity and type II diabetes. We recently reported that UCP2 expression is increased...Full Text Available
Metazoan life cycles can be complex in different ways. A number of diverse phenotypes and reproductive events can sequentially occur along the cycle, and at certain stages a variety of developmental...Full Text Available
A number of aberrant morphological phenotypes were noted during propagation of the Arabidopsis thaliana DNA hypomethylation mutant, ddm1, by repeated self-pollination. Onset of a spectrum of morphological...Full Text Available
A strain from human diarrhea originally identified as Campylobacter mucosalis (NCTC 12408) was examined by using 64 phenotypic characters. The similarity of this strain to 297 isolates of Campylobacter,...Full Text Available
Mechanisms for differential regulation of gene expression may underlie much of the phenotypic variation and adaptability of malaria parasites. Here we describe transcriptional variation among culture-adapted...Full Text Available
PurposeTo analyze the contributions of cytochrome P4501B1 (CYP1B1) mutations to primary congenital glaucoma (PCG) in Spanish patients.MethodsWe...Full Text Available
SummaryDNA-based tests are increasingly being used to predict a blood group phenotype. This is possible because genes encoding 29 of the 30 blood group systems have been cloned and sequenced,...Full Text Available
Skin and hair phenotypes are powerful cues in human communication. They impart much information, not least about our racial, ethnic, health, gender and age status. In the case of the latter parameter,...Full Text Available
BackgroundBlood group O has been significantly associated with increased placental malaria infection in primiparae and reduced risk of infection in multiparae in the Gambia, an area...Full Text Available
Human arylamine N-acetyltransferase (NAT) activity is determined by two distinct genes, NAT1 and NAT2, and the classical acetylation polymorphism in NAT2 has been associated with a variety of disorders,...Full Text Available
PurposeTo detail the highly variable ocular phenotypes of a French family affected with an autosomal dominantly inherited vitreoretinopathy and to identify the disease gene.MethodsSixteen...Full Text Available
A plethora of experimental studies use mtDNA as a marker of demographic processes without questioning the possibility that selection may bias their interpretations. We studied four lines of Drosophila melanogaster that have a standardized nuclear DNA but variable mtDNA. We completed the sequencing of the mitochondrial genomes (excluding the A+T rich region) and compiled the differences. We then assayed male influence on oviposition, starvation resistance, lipid proportion and physical activity. We discuss these results in terms of the known differences between the lines and conclude that naturally occurring mtDNA variants in D. melanogaster are expressed at the level of the organismal phenotype. PMID:21757031
As the presence of humans in space expands in scope and duration, the quality of life in space as well as on Earth becomes pertinent. .... Military uses of space, such as the introduction of space-based laser or particle beam weapons, may have a major impact on the way people think and relate to .... AIAA Student Journal. ...
The Los Alamos Nuclear Material Accounting and Safeguards System (MASS) is a near-real-time accountability system for bulk materials, discrete items, and material undergoing dynamic processing. MASS has evolved from an eighty-column card based process control system to a very sophisticated computer system. The security of the MASS computer system is provide through various access controls. There are two kinds of access control to be addressed. They are physical access control to the hardware which make up the system, and access control to the software. There are many features which provide a measure of security to the hardware that will be discussed. Access to the software is controlled by a security password. Access to various transaction activities in the system is controlled through the level of MASS user privilege. Details of MASS user privilege will be ...
... the major types of vascular access catheters: A peripherally inserted central catheter (PICC) is a long catheter that extends ... the procedure performed? A midline catheter and some peripherally inserted central catheter (PICC) lines may be inserted at your ...
Many healthcare organizations utilize network "firewalls" to protect their networks from being accessed by unauthorized external entities. These same firewalls are also often configured to deny access...Full Text Available
BackgroundPersonal health records (PHRs) provide patients with access to personal health information (PHI) and targeted education. The use of PHRs has the potential to improve a...Full Text Available
BackgroundThe survival of hemodialysis patients requiring dialysis depends on the long-term functioning and patency of the vascular access. Prosthetic vascular grafts are inevitably...Full Text Available
Femtocells are assuming an increasingly important role in the coverage and capacity of cellular networks. In contrast to existing cellular systems, femtocells are end-user deployed and controlled, randomly located, and rely on third party backhaul (e.g. DSL or cable modem). Femtocells can be configured to be either open access or closed access. Open access allows an arbitrary nearby cellular user to use the femtocell, whereas closed access restricts the use of the femtocell to users explicitly approved by the owner. Seemingly, the network operator would prefer an open access deployment since this provides an inexpensive way to expand their network capabilities, whereas the femtocell owner would prefer closed access, in order to keep the femtocell's capacity and backhaul to himself. We show mathematically and through simulations that the reality is more ...
This purpose of this paper is to describe the optimizing Peripherally Inserted Central Catheter (PICC) insertion, revising data collection strategies, estimating workloads, and calculating the financial savings generated by the vascular access nurse (VAN)...
Considering accessibility of the 3′UTR is believed to increase the precision of microRNA target predictions. We show that, contrary to common belief, ranking by the hybridization energy or by...Full Text Available
ObjectiveTo estimate the joint effect of a multifaceted access intervention on primary care physician (PCP) productivity in a large, integrated prepaid group practice.Data...Full Text Available
This certifies that the face of Flat Granny has flown in space aboard the Space Shuttle Discovery on mission STS-. 133 from February 24 - March 9, 2011. ...
The Bantam System Technology Project is one element of the Advanced Space Transportation Program -- a NASA initiative to reduce the cost of space launch and ...
Sep 3, 2010 ... These higher-quality deformable mirrors will enable diffraction-limited performance for many space-based optical systems such as space-based ...
sharing data and computational resources, and accessing information in digital libraries." Bill Wulf (1989) In a Collaboratory, the presentation/meeting concept embodied...
... Uninterrupted access to and use of critical infrastructure in the Arabian Gulf region are key to the successful prosecution of the Global War on Terror ...
Distribution of restricted information (see wikileaks); Restricting Access to as advertised open discussion groups. Gives impression of consensus by ...
An important goal for digital libraries is to enable researchers to more easily explore related work. While citation data is often used as an indicator of relatedness, in this paper we demonstrate that digital access records (e.g. http-server logs) can be used as indicators as well. In particular, we show that measures based on co-access provide better coverage than co-citation, that they are available much sooner, and that they are more accurate for recent papers.
To reduce the number of regular break-ins on CERN machines due to passwords exposed on the network in clear text, OFF-SITE FTP ACCESS TO CERN WILL BE BLOCKED in the CERN firewall from: Tuesday 20th January 2004 If you use ftp to access CERN computers from outside CERN then please see the link below for alternative access means and further advice: http://cern.ch/security/ftp Denise Heagerty, CERN Computer Security officer, Computer.Security@cern.ch
To reduce the number of regular break-ins on CERN machines due to passwords exposed on the network in clear text, OFF-SITE FTP ACCESS TO CERN WILL BE BLOCKED in the CERN firewall from: Tuesday 20th January 2004 If you use ftp to access CERN computers from outside CERN then please see the link below for alternative access means and further advice: http://cern.ch/security/ftp Denise Heagerty, CERN Computer Security officer, Computer.Security@cern.ch
... 1 (2008) Algorithms - Open Access Journal Algorithms (ISSN 1999-4893; CODEN: ALGOCH), an open access journal of computer science, theory, methods and interdisciplinary applications, data and information systems, software engineering, artificial intelligence, automation and control systems, is published online quarterly by MDPI. - free for readers, with low publishing fees paid by authors or their institutions High visibility: indexed in leading indexing and abstracting databases....
The Space Task Group in its study of future directions in space, with ..... almost $6 billion and a peak civil service and contractor work force of 420000 people. ..... space organizations permitting assumptions of primary or joint responsibility for ...
Papers are presented on space power requirements and issues, space photovoltaic systems, space solar dynamic systems, space thermal systems, manned and unmanned space power systems, thermionics, and thermoelectrics. Also considered are high power devices for space power systems, high power conversion for space power systems, 1-10 kWe nuclear space power sources, 100-kW class nuclear power concepts, space reactor safety, and multimegawatt space nuclear power systems. Other topics include space power systems automation, space kilovolt technology, space power electronics, space lithium and nickel-cadmium batteries, lithium sodium storage, and space fuel cells. Papers are also ...
Transient Enhanced Diffusion (TED) of dopants in Si is the consequence of the evolution, upon annealing, of a large supersaturation of Si self-interstitial atoms left after ion bombardment. In the case of amorphizing implants, this supersaturation is located just beneath the c/a interface and evolves through the nucleation and growth of End-Of-Range (EOR) defects. For this reason, the authors discuss here the relation between TED and EOR defects. Modelling of the behavior of these defects upon annealing allows one to understand why and how they affect dopant diffusion. This is possible through the development of the Ostwald ripening theory applied to extrinsic dislocation loops. This theory is shown to be readily able to quantitatively describe the evolution of the defect population (density, size) upon annealing and gives access to the variations of the mean supersaturation of Si self-interstitial atoms between the loops and responsible for TED. This initial ...
Transient Enhanced Diffusion (TED) of dopants in Si is the consequence of the evolution, upon annealing, of a large supersaturation of Si self-interstitial atoms left after ion bombardment. In the case of amorphizing implants, this supersaturation is located just beneath the c/a interface and evolves through the nucleation and growth of End-Of-Range (EOR) defects. For this reason, the authors discuss here the relation between TED and EOR defects. Modelling of the behavior of these defects upon annealing allows one to understand why and how they affect dopant diffusion. This is possible through the development of the Ostwald ripening theory applied to extrinsic dislocation loops. This theory is shown to be readily able to quantitatively describe the evolution of the defect population (density, size) upon annealing and gives access to the variations of the mean supersaturation of Si self-interstitial atoms between the loops and responsible for TED. This initial ...
Full text: Secure, reliable and cost-effective communications are becoming an increasingly important tool for safeguards verification. This trend began with the initiation of remote monitoring implementation, where secure and cost effective data communications were required both to satisfy the confidentiality requirements of Member States and in order to meet the rigorous data authenticity requirements which allow the International Atomic Energy Agency (IAEA) to draw credible and independent conclusions. In addition, the implementation of additional protocols and integrated safeguards increases the importance of information (obtained in the course of an inspection, visit, complementary access or design information verification) being analyzed and corroborated with other information sources stored at IAEA Headquarters or Regional Offices, often while the inspector is still on-site. This requires the capability of enabling the inspector, wherever he is in the field, ...
This thesis presents a theoretical analysis of the properties of the Higgs bosons in the standard model (SM) and the minimal supersymmetric extension (MSSM), which can be investigated at the LHC and e"+e"- linear colliders. The final goal is the reconstruction of the Higgs potential and thus the verification of the Higgs mechanism. MSSM Higgs boson production processes at future #gamma##gamma# colliders are calculated in several decay channels. Heavy scalar and pseudoscalar Higgs bosons can be discovered in the bb final state in the investigated mass range 200 to 800 GeV for moderate and large values of tan#beta#. The #tau#"+#tau#"- channel provides a heavy Higgs boson discovery potential for large values of tan#beta#. Several mechanisms that can be exploited at e"+e"- linear colliders for the measurement of the lifetime of a SM Higgs boson in the intermediate mass range are analysed. In the WW mode, the lifetime of Higgs scalars with masses below #propor to#160 GeV can be determined ...
In this paper, we evaluate the performance of the 1- and 5-site models of methane on the description of adsorption on graphite surfaces and in graphitic slit pores. These models have been known to perform well in the description of the fluid-phase behavior and vapor-liquid equilibria. Their performance in adsorption is evaluated in this work for nonporous graphitized thermal carbon black, and simulation results are compared with the experimental data of Avgul and Kiselev (Chemistry and Physics of Carbon; Dekker: New York, 1970; Vol. 6, p 1). On this nonporous surface, it is found that these models perform as well on isotherms at various temperatures as they do on the experimental isosteric heat for adsorption on a graphite surface. They are then tested for their performance in predicting the adsorption isotherms in graphitic slit pores, in which we would like to explore the effect of confinement on the molecule packing. Pore widths of 10 and 20 A are chosen in this investigation, and ...
Computerized tomography-guided neurolytic splanchnic nerve block is a technique for relieving abdominal cancer pain; the goal is the alcoholic neurolytic interruption of the sensitive structures in retroperitoneal space. Computerized tomography yields accurate anatomical detailing and the course for needle placement and alcohol spread. January, 1993, to July, 1996, twenty-one bilateral splanchnic nerve blocks were performed through the posterior access. Forty-eight hours after alcoholism. 14 patients (66%) had complete pain regression; 52% of the patients needed no analgesics for 6 to 54 days and only 9 patients (42%) needed another low opioid therapy. Complications included hypotension and diarrhea in all cases. One had a cardiac arrest and diet 8 days after the procedure. There were no other complications. The whole procedure usually lasted 60 min (range: 45 to 90 min). Splanchnic nerve neurolysis is a useful treatment in the patients with ...
Difficulty in recalling the names of people is very common in the early stages of Alzheimer's disease and in mild cognitive impairment (MCI). However, it is not known whether the difficulty in naming people in MCI reflects problems associated with lexical access or with semantic access. The aims of the present study were to investigate semantic and phonological access to proper names by use of a Tip-of-the-tongue (TOT) task in individuals with multidomain amnestic MCI, individuals with amnestic MCI, and healthy controls, as well as to study the relationships between TOT production and performance in a free recall verbal memory test. In the individuals with multidomain amnestic MCI, the main process affected was phonological access; failures in phonological access were related to deficits i...
We combine establishment-level employment data with trade data by port to examine the impact of accession to the European Economic Community on the spatial distribution of UK manufacturing. We test the predictions from economic geography models of how external trade affects the spatial distribution of employment. We treat accession as a natural experiment which helps mitigate problems of endogeneity. Our results suggest that accession changed the country composition of trade and via the port composition induced an exogenous shock to different locations. In line with theory, we find that better access to export markets and intermediate goods increase employment while increased import competition decreases employment.
It has been widely assumed that South Africa has achieved universal basic education. Through an analysis of the 2001 census and two national enrolment datasets rather than statistical projections, this study re-examines this assumption and provides new estimates of enrolment levels in primary, basic and secondary education. Using GER, NER, and ASER indicators, disaggregated by gender and province, the study shows that access to education in South Africa is not as widespread as published sources note. While statistics show that national access levels are lower than prevailing estimates, the relatively high levels of access in some of the most disadvantaged provinces suggest the need to re-evaluate assumptions about targets for universal access for developing regions. In addition, the analysis reveals South Africa's unexpected and provocative gendered patterns of access and ...
A relocatable storage magazine apparatus for storing and retrieving explosives and ordnance and for partially containing and attenuating the blast, conflagration and flying debris from an accidental explosion is described comprising: (a) a container having an access hole; (b) a debris trap attached to the container, the debris trap communicating with said container via the access hole, said debris trap having vent holes for venting the pressure of an explosion from said debris trap to the atmosphere; (c) means for covering said access hole; (d) means for suspending explosives and ordnance from the covering means; (e) means for entering the storage magazine to store and retrieve explosives and ordnance; (f) means for retaining said covering means in a position above the access hole wherein said explosives and ordnance are accessible from the entering means.
We analyzed the phenotypic variation of baobab (Adansonia digitata L.) fruits from Mali to define the domestication potential of this species. 269 trees, selected from 10 provenances distributed along a rainfall gradient, were characterized. Five fruits were sampled from each tree. Total individual fruit weight was partitioned into shell, pulp, and seed weight. Ratios were calculated between pulp?+?seed and total weight, and between pulp and seed weight. For all the measured fruit traits, we detected significant differences between provenances, as well as between trees from the same provenance. Assuming that the measured traits are under genetic control, the latter facts indicate that there are considerable opportunities for tree selection on a local scale. However, candidate plus trees wi...
Phenotypic plasticity can facilitate reproductive strategies that maximize mating success in variable environments and lead to differences in sex allocation among populations. For simultaneous hermaphrodites with sperm competition, including Serranus tortugarum a small coral reef fish, proportional male allocation (testis in total gonad) is often greater where local density or mating group size is higher. We tested whether S. tortugarum reduced male allocation when transplanted from a higher density site to a lower density site. After 4?months, transplants mirrored the sex-allocation patterns of the resident population on their new reef. Transplants had significantly lower male allocation than representatives from their source population, largely as a result of reduced testis mass relative...
Parasites display considerable phenotypic plasticity in life-history traits such as, body size. Varroa destructor is an ectoparasitic mite of the western honey bee Apis mellifera. Several studies have reported that in V. destructor, there is a wide phenotypic plasticity within a population of mites. However, it is unknown if there are morphologic variations in V. destructor populations affecting different A. mellifera populations. A morphometric study of V. destructor populations was conducted to provide information concerned to the relationships among parasite populations found in different geographic locations from A. mellifera colonies of Argentina. The hypothesis tested was different morphotypes of V. destructor populations parasitizing different A. mellifera populations from Argentina...
This document consist of brief reports prepared by postdoctoral students supported by the project, each describing his accomplishments under the grant. Topics include (1) Malignant Transformation of MSU-1. 1 Cells by Gamma Radiation, (2) Correlation between Levels of ras Expression and Presence of Transformed Phenotypes Including Tumorigenicity, Using a Modulatable Promoter, (3) Relation between Specific rad Oncogene Expression, (4) Correlation of Genetic Changes in Fibroblastic Tumors with Malignancies, (5)Transformation of MSU-1.1 Cells by sis Oncogene, (6) Malignant Transformation of MSU-1.0 Cells, (7) Correlation of Urokinase Plasminogen Activation (mu-PA) with Malignant Phenotype, (8)Two Dimensional Gel Electrophoresis Studies of the Proteins of the Major Cell Strains of the MSU-1 Family of Cells, and (9) Correlation between Proteinase Activity Levels and Malignancy.
Through an unusual differentiation process, human trophoblast progenitors (cytotrophoblasts) give rise to tumor-like cells that invade the uterus. By an unknown mechanism, invasive cytotrophoblasts exhibit permanent cell cycle withdrawal. Here we report molecular cytogenetic data showing that {approx} 20 to 60 percent of these interphase cells had acquired aneusomies involving chromosomes X, Y, o r16. The incidence positively correlated with gestational age and differentiation to an invasive phenotype. Scoring 12 chromosomes in flow-sorted cytotrophoblasts showed that more than 95 percent of the cells were hyperdiploid. Thus, aneuploidy appears to be an important component of normal placentation, perhaps limiting the proliferative and invasive potential of cytotrophoblasts within the uterus.
Summary 1. Plants express multiple defensive traits, but little is known about the genetic stability and phenotypic plasticity of these traits in nature. To investigate sources of variation and their potential ecological consequences for herbivores, we combined field observations of cyanogenic lima bean with laboratory experiments. 2. Field studies in South Mexico revealed a distinct variability of cyanogenic traits within and among wild lima bean populations. To differentiate among genetic variation and the impact of ambient conditions on plant phenotypes, we used seed grown plants as well as clones propagated from high (HC) and low cyanogenic (LC) wild type plants. 3. In growth chamber experiments, we cultivated plants under three intensities each of drought and salt stress, nutrient sup...
Abstract Gelatinization temperature (GT) is an important parameter in evaluating the cooking and eating quality of rice. Indeed, the phenotype, biochemistry and inheritance of GT have been widely studied in recent times. Previous map-based cloning revealed that GT was controlled by ALK gene, which encodes a putative soluble starch synthase II-3. Complementation vector and RNAi vector were constructed and transformed into Nipponbare mediated by Agrobacterium. Phenotypic and molecular analyses of transgenic lines provided direct evidence for ALK as a key gene for GT. Meanwhile, amylose content, gel consistency and pasting properties were also affected in transgenic lines. Two of four nonsynonymous single nucleotide polymorphisms in coding sequence of ALK were identified as essential for GT. ...
Most common bacterial species causing peritonitis in the course of peritoneal dialysis (PDP) are coagulase-negative staphylococci, Staphylococcus aureus and streptococci. Haemophilus influenzae is rarely associated with PDP. Hereby we present the first known case of APD-associated peritonitis caused by non-type able H. influenzae (NTHi) presenting the beta-lactamase negative, ampicillin-resistant (BLNAR) phenotype. An 18 year old boy who had been treated with the APD for 12 months due to SLE was admitted in good general condition with diagnosis of PDP. Standard diagnostic and therapeutical procedures were initiated. Dialysis fluid was turbid with cytosis of 435 WBC/ml. From dialysis fluid pure culture of Gram-negative coccobacillus was isolated. The isolate was identified as a BLNAR phenotype. The same bacterium was isolated from nasal swab. Blood cultures were negative. After evaluation of antimicrobial susceptibility the treatment was changed ...
Twenty-two landrace-derived inbred lines from the Spanish Barley Core Collection (SBCC) were found to display high levels of resistance to a panel of 27 isolates of the fungus Blumeria graminis that exhibit a wide variety of virulences. Among these lines, SBCC145 showed high overall resistance and a distinctive spectrum of resistance compared with the other lines. Against this background, the main goal of the present work was to investigate the genetic basis underlying such resistance using a doubled haploid population derived from a cross between SBCC145 and the elite spring cultivar Beatrix. The population was genotyped with the 1,536-SNP Illumina GoldenGate Oligonucleotide Pool Assay (Barley OPA-1 or BOPA1 for short), whereas phenotypic analysis was performed using two B. graminis isolates. A major quantitative trait locus (QTL) for resistance to both isolates was identified on the long arm of chromosome 6H (6HL) and accounted for ca. 60% of the ...
The deregulated kinase activity of p210-BCR/ABL oncoproteins, hallmark of chronic myelogenous leukaemia (CML), induces and sustains the leukaemic phenotype, and contributes to disease progression....Full Text Available
BackgroundPlasmid encoded blaCTX-M enzymes represent an important sub-group of class A β-lactamases causing the ESBL phenotype which is increasingly...Full Text Available
BackgroundEstrogen receptors alpha (ERα) and beta (ERβ) are transcription factors (TFs) that mediate estrogen signaling and define the hormone-responsive phenotype...Full Text Available
Rice is a very important food staple that feeds more than half the world's population. Two major Asian cultivated rice (Oryza sativa L.) subspecies, japonica and indica, show significant phenotypic variation in their stress responses. However, the molecular mechanisms underlying this phenotypic variation are still largely unknown. A common link among different stresses is that they produce an oxidative burst and result in an increase of reactive oxygen species (ROS). In this study, methyl viologen (MV) as a ROS agent was applied to investigate the rice oxidative stress response. We observed that 93-11 (indica) seedlings exhibited leaf senescence with severe lesions under MV treatment compared to Nipponbare (japonica). Whole-genome microarray experiments were conducted, and 1,062 probe sets were identified with gene expression level polymorphisms between the two rice cultivars in addition to differential expression under MV treatment, which were ...
APP is a transmembrane precursor of beta-amyloid. In dominantly inherited familial Alzheimer's disease (FAD), point mutations V6421, V642F and V642G have been discovered in APP695. Here we show that...Full Text Available
PurposeTo describe clinical data and to characterize mutations in the transforming growth factor beta-induced (TGFBI) gene in patients from three unrelated Chilean...Full Text Available
Neutrophils from people with poorly controlled diabetes present a primed phenotype and secrete excessive superoxide. Phospholipase A2 (PLA2)-derived arachidonic acid (AA)...Full Text Available
Loss-of-function mutations in the regulatory gene areA of Aspergillus nidulans prevent the utilization of a wide variety of nitrogen sources. The phenotypes of nit-2 mutants of Neurospora crassa suggest...Full Text Available
Mutations in the FGD1 gene have been shown to cause Aarskog-Scott syndrome (AAS), or facio-digito-genital dysplasia (OMIM#305400), an X-linked disorder characterized by distinctive genital and skeletal developmental abnormalities with a broad spectrum of clinical phenotypes. To date, 20 distinct mutations have been reported, but little phenotypic data are available on patients with molecularly confirmed AAS. In the present study, we report on our experience of screening for mutations in the FGD1 gene in a cohort of 60 European patients with a clinically suspected diagnosis of AAS. We identified nine novel mutations in 11 patients (detection rate of 18.33%), including three missense mutations (p.R402Q; p.S558W; p.K748E), four truncating mutations (p.Y530X; p.R656X; c.806delC; c.1620delC), one in-frame deletion (c.2020_2022delGAG) and the first reported splice site mutation (c.1935+3A>C). A recurrent mutation (p.R656X) was detected in three ...
A crucial step in human breast cancer progression is the acquisition of invasiveness. There is a distinct lack of human cell culture models to study the transition from pre-invasive to invasive phenotype as it may occur 'spontaneously' in vivo. To delineate molecular alterations important for this transition, we isolated human breast epithelial cell lines that showed partial loss of tissue polarity in three-dimensional reconstituted-basement membrane cultures. These cells remained non-invasive; however, unlike their non-malignant counterparts, they exhibited a high propensity to acquire invasiveness through basement membrane in culture. The genomic aberrations and gene expression profiles of the cells in this model showed a high degree of similarity to primary breast tumor profiles. The xenograft tumors formed by the cell lines in three different microenvironments in nude mice displayed metaplastic phenotypes, including ...
The technology for performance testing and improvement of materials which are durable at space environment is a military related technology and veiled and securely regulated in advanced countries such as US and Russia. This core technology cannot be easily transferred to other country too. Therefore, this technology is the most fundamental and necessary research area for the successful establishment of space environment system. Since the task for evaluating the effects of space materials and components by space radiation plays important role in satellite lifetime extension and running failure percentage decrease, it is necessary to establish simulated space radiation facility and systematic testing procedure. This report has dealt with the status of the technology to enable the simulation of space environment effects, including the effect of ...
For 21st century warfare, space is the unquestioned new high ground for military operations. The United States (U.S.) has relied on satellites for significant support to military operations and activities since Desert Storm in 1991. Indeed, the U.S. enjoys an asymmetric advantage in modern warfare utilizing our space capabilities. States with interests hostile to the U.S. believe that the significant dependence on space assets by the U.S. military could become its "Achilles heel" in future combat operations. What are the legal and policy bases for the U.S. to respond to threats to space systems that provide support to our military forces? Should the U.S. rely on space arms control initiatives to ensure security in space? This Viewpoint analyzes the international space law regime and U.S. N...
Having always been at the forefront of information management and open access, High-Energy Physics (HEP) proves to be an ideal test-bed for innovations in scholarly communication including new information and communication technologies. Three selected topics of scholarly communication in High-Energy Physics are presented here: A new open access business model, SCOAP3, a world-wide sponsoring consortium for peer-reviewed HEP literature; the design, development and deployment of an e-infrastructure for information management; and the emerging debate on long-term preservation, re-use and (open) access to HEP data.
... Accession Number : ADD815206. Title : Waterjet Cutting System Adds Value to Titanium Parts. Descriptive Note : Journal article. Corporate Author : ...
... Accession Number : AD0749455. Title : Uptake and Retention of Adenine Moiety by Stored Human Red Blood Cells. Descriptive Note : Interim rept.,. ...
As the amount of biological data grows, so does the need for biologists to store and access this information in central repositories in a free and unambiguous manner. The European Bioinformatics Institute...Full Text Available
Over the past three decades, rising competition from television and other new media prompted the FCC to ease the responsibilities of radio stations to maintain extensive records of issues programming, while retaining the responsibility of stations to provide ready public access to records. This study investigated the availability of Issues-Programs Lists in nearly 100 Missouri radio station Public Files. One in five randomly sampled stations failed to produce access to Lists upon demand as required under federal law. Noncompliance themes include: Inability to access Public Files within 20 minutes of face-to-face requests; station personnel with limited or no knowledge of Files; denial of access to Files and Lists (i.e., verbal refusals, locked studio doors); and incomplete Files. The rate ...
The Python programming language is steadily increasing in popularity as the language of choice for scientific computing. The ability of this scripting environment to access a huge code base in various...Full Text Available
may experience difficulty opening the Facebook page due to current HHS policy and network security that blocks access to the site. Site Map - Contact Us - Linking to USPHS.gov -...
... Accession Number : ADD135818. Title : Performance of Titanium in Flue Gas Desulfurization Scrubber Systems,. Descriptive Note : Journal Article,. ...
The tremendous growth of wireless technologies has introduced the potential of continuous service adaptation to the users' needs by giving them the ability to be able to select and access the proper network based on different criteria. Moreover, next generation wireless networks have been designed to provide support for multimedia services, with different traffic characteristics and different Quality of Service (QoS) guarantees. However, the expansion of Wireless Local Area Networks (WLANs) and Worldwide Interoperability for Microwave Access (WiMAX) networks poses new research era in the decision of the access network selection. In this paper, the existing access network selection schemes are classified into three categories: the network-centric, the user-centric and the collaborative sche...
... Accession Number : ADD431225. Title : Influence of Fiber Loading on Thermal Ablation of PTFE,. Corporate Author : Personal Author(s) : Letson,KN. ...
Background An increasing number of people have access to the Internet, and more people are seeking tobacco cessation resources online every year. Despite the...Full Text Available
The eye is an easily accessible, highly compartmentalised and immune-privileged organ that offers unique advantages as a gene therapy target. Significant advancements have been made in understanding...Full Text Available
SummaryNineteenth-century Vienna is well known to medical historians as a leading centre of medical research and education, offering easy access to patients and corpses to students...Full Text Available
High-throughput genomic and proteomic technologies have generated a wealth of publicly available data on ageing. Easy access to these data, and their computational analysis, is of great importance in...Full Text Available
... Uninterrupted access to and use of critical infrastructure in the Arabian Gulf region are key to the successful prosecution of the Global War on Terror ...
respectively. This is a NASA and GSFC requirement to help ensure our computer and network security on center. In the near future, ftp access, with the exception of anonymous ftp of...
... Fuels", Paper AIAA-91-2451, 27th AIAA/SAE/ASME ... to-surface ballistic missiles than space-based space-to ... an effective hit-to-kill weapon without the ...
The phase space of quantized systems that contain tachyons has been investigated. Interpretation difficulties and unexpected divergences are found when it is considered the volume of Lorentz-invariant phase space. These problems can be overcome, however, at the expense of Lorentz invariance.
The phase space of quantized systems that contain tachyons has been investigated. Interpretation difficulties and unexpected divergences are found when we consider the volume of Lorentz-invariant phase space. These problems can be overcome, however, at the expense of Lorentz invariance.
If B is a compact space and B\\{pt} is Lindelof then B^k\\{pt} is star-Linedlof for every cardinality k. If B\\{pt} is compact then B^k\\{pt} is discretely star-Lindelof. In particular, this gives new examples of Tychonoff discretely star-Lindelof spaces with unlimited extent.
NASA Administrator Charles Bolden, who flew four space shuttle missions, talks about how space travel changed his life and how he applies his astronaut training to his work as the head of the space agency.
The Vision for Space Exploration will guide NASA's future human and robotic space activities. The broad range of human and robotic missions now being planned will require the development of new system-level capabilities enabled by emerging new technologie...
Recently Stephen Theriault and I found an elementary construction of Anick's spaces and proved their main properties(arXiv:0710.1024).In this work the fundamental fibration is decomposed. This is useful in studying maps out of Anick's spaces and will be needed in order to determine it's universal properties.
This paper summarizes the establishment and current development of space activities in the Bolivarian Republic of Venezuela. Space activities in Venezuela are focused on the areas of telecommunications, Earth observation and research on the physical properties of the Earth, and have as a primary goal the satisfaction of social needs. Current development of space activities started in 1999 when the new National Constitution recognized the value of outer space as the common heritage of mankind, and the key role of science and technology in promoting human welfare. The Bolivarian Agency for Space Activities (ABAE) was created in 2007. Its legal framework recognizes three key elements that drive its policy: the participation of society, capacity building and human training, and international c...
11 matches ... 04.17.2002. International Space Station Sports a New Truss + More Details. 04.17 .2002. International Space Station Sports a New Truss ...
... hypersonic aerodynamic force, or the space-equivalent region. Some of these experiments change the X-15 from a research airplane to a kind of space probe, ...
He commanded the 50th Space Wing, which is responsible for 60 satellites. ... to produce space systems and launchers capable of tailored military effects on ...
(AIM PAPER 81-1628). Three different examples will be given to illustrate how a ...... Power System (PS), and a Science Applications and Space Platform ...
"Report of the Ad Hoc Subpanel on Reusable Launch Vehicle Technology. ... The author comments that the United State's space transportation system is ...
The aim of this paper is to present the phase-space properties of the systems that contain bradyons, luxons and tachyons. It is shown that particularly at low energy, these properties are quite different from the well-known properties of bradyons.
We show that the moduli space of all Calabi-Yau manifolds that can be realized as hypersurfaces described by a transverse polynomial in a four dimensional weighted projective space, is connected. This is achieved by exploiting techniques of toric geometry and the construction of Batyrev that relate Calabi-Yau manifolds to reflexive polyhedra. Taken together with the previously known fact that the moduli space of all CICY's is connected, and is moreover connected to the moduli space of the present class of Calabi-Yau manifolds (since the quintic threefold P_4[5] is both CICY and a hypersurface in a weighted P_4), this strongly suggests that the moduli space of all simply connected Calabi-yau manifolds is connected. It is of interest that singular Calabi-Yau manifolds corresponding to the points in which the moduli spaces meet are often, for the present class, ...
Jul 15, 2004 ... Responding to the recommendations of the President's Commission on Implementation of United States Space Exploration Policy, NASA is teaming ...
... of China Lake Naval Weapons Center, California. ... Figure 4: The Space-Based Laser cleaning ... of Aeronautics and Astronautics (AIAA) Space 2001 ...
... to de-scope the weapon system. ... AIAA American Institute of Aeronautics and Astronomy ... Nations BASIC Broad Area Space-Based Imagery Collector ...
Sep 5, 1996 ... In Haiti, the military deployed a space support team to advise the task force commander on the effective use of space assets, such as the Milstar ...
Diffusion in the extracellular space (ECS) of the brain is constrained by the volume fraction and the tortuosity and a modified diffusion equation represents the transport behavior of many molecules...Full Text Available
our exploration of space, in a manner with improved safety. ... a new Space Transportation System. ... Columbia launches as STS-107 on January 16, 2003. ...
... perform the inspection in the extremely limited space between adjacent blades and at the blade root, miniature eddy current probes were developed ...
... reliability of fiber optics in preference over space-based systems. ... STC web site at www.aiaa.org/tc ... and improve lethalities of US weapon systems 3 ...
The actual mechanisms that maintain the individual disparities in home computer use and internet access that are collectively termed “the digital divide” remain unclear. We hypothesized...Full Text Available
The new collaborative exploitation of the JET Facilities requires suitable technical tools and infrastructure measures to enable the Remote Participation of scientists from all European Fusion labs. Such measures are being gradually introduced. They comprise of a toolkit for Remote Data Access, Remote Computer Access and for teleconferencing, and of infrastructure measures that address network connectivity, network security, shared documentation and technical support.
Assisted users with expired passwords Closed 233 NCICB Support Wizard Accounts Tickets Set up Resource Accounts for individual developers to control and track access on QA Application servers Maintained daily account synchronization between GForge project developers and CVS write access accounts Created FTP and SFTP user accounts for TCGA test, analysis datasets downloads and analysis datasets management.
A nozzle plug for blocking a nozzle in a nuclear steam generator is improved by the addition of hinges which allow the nozzle plug to be inserted into the steam generator through an access port of substantially smaller diameter than the nozzle. A recess is provided in one of the semi-circular plates allowing the plates to nest, further reducing the necessary size of the access port.
Background:Timely access to publicly funded health services is a priority issue across the healthcare continuum in Canada. The purpose of this study was to examine wait list management...Full Text Available
Metadata can be used to support accessibility in connection with improved discovery. ...certain metadata elements provide information about what capabilities are needed--either perceptual-motor, cognitive, socio-economic or geographic--to make use of a resource. This cam improve the ability of users who are disadvantaged in these ways to find resources that meet their needs--and avoid ones [resources] that do not.
This article describes a flexible and extensible infrastructure for applying Web-Technologies to embedded systems.The presented approach develops a Three-level-Architecture consisting of the embedded system, the universal Remote-Access-Server and the Remote-Access-Client. A system-spanning general interface allows the binding of embedded systems in order to access their process data. Additionally, this procedure facilitates a flexible processing of the device data, so that it is ready to be used by different control devices. To ensure flexibility - connecting different devices on the one side and providing information for different clients like PC, PDA or mobile phone on the other side - a new XML-based description language (Service Description Markup Language - SDML) is introduced. The SDML documents contain information about connected embedded systems, reusable device data and the presentation policies for different ...
Three normal human diploid cell strains were transfected with an activated Ha-ras oncogene (EJ ras) or SV40 T-antigen. Multiple clones were examined for morphological alterations, growth requirements, ability to grow under anchorage independent conditions, immortality and tumorigenicity in nude mice. Clones expressing SV40 T-antigen alone or in combination with ras protein p21 were significantly radioresistant as compared with their parent cells or clones transfected with the neo gene only. This radioresistant phenotype persisted in post-crisis, immortalized cell lines. These data suggest that expression of the SV40 T-antigen but not activated Ha-ras plays an important role in the radiosensitivity of human diploid cells. The radioresistant phenotype in SV40 T transfected cells was not related to the enhanced level of genetic instability seen in pre-crisis and newly immortalized cells, nor to the process of immortalization itself. (author).
Fingerprinting of Penicillium crustosum strains was performed using different phenotypic characteristics. Seven strains of this extremely homogenous species were selected; of these, five originated from geographical locations characterized by low temperatures, and one from a location with a low water activity. Principal component analysis (PCA) was performed using micromorphological data, temperature- and water-dependent growth rates, and extrolite profiles obtained by HPLC analysis. The micromorphological data were less informative, while the growth-rate data were informative only if the strains investigated already showed slight adaptations to the selected external parameter. In contrast, PCA analyses of the extrolite data showed groupings of the strains according to their origins and known physiological differences. These groupings are in full agreement with the clustering obtained by previous amplified fragment length polymorphism (AFLP) study. We thus ...
We investigated the in vitro phenotypic transformation of human embryo (HE) cells that were repeatedly irradiated (7.5 cGy once a week) throughout their life-span. Irradiation was repeated until the cells had accumulated 195 cGy (equivalent to the 26th passage). Samples of cells were assayed for survival by colony formation, as well as for mutation at the hypoxanthine guanine phosphoribosyl transferase (HGPRT) locus and for transformation by focus formation. The life-span (mean number of population doublings) of multiply irradiated cells with a total dose of 97.5 cGy was slightly but significantly prolonged over that of controls. After HE cells had accumulated 195 cGy, the maximum number of divisions increased to 130-160% of the number in non-irradiated control cells. Transformed foci were not observed until cells had accumulated 97.5 cGy, and then increased with the increasing accumulation of radiation. However, no cells showed immortality or expressed a malignant ...
In this study, adipose-derived stem cells (ASCs) were cocultured with nucleus pulposus (NP) cells using a porous membrane to investigate the effect of NP cell phenotype on ASC chondrogenic differentiation. Human NP cells were collected from 14 patients and classified into two groups (normal vs. degenerative) depending on the level of type II collagen, aggrecan (AGG), type I collagen, and bax gene expression. Human ASCs were then cocultured with each group of NP cells on porous membranes in the absence of chondrogenic supplements. After 2 weeks, real-time-polymerase chain reaction results showed that ASCs cocultured with normal NP cells had much higher type II collagen and AGG gene expression than ASCs cocultured with degenerative NP cells. The production of AGG was also observed only in th...
The classical phenomenon of position-effect variegation (PEV) is the mosaic expression that occurs when a chromosomal rearrangements moves a euchromatic gene near heterochromatin. A striking feature of this phenomenon is that genes far away from the junction with heterochromatin can be affected, as if the heterochromatic state {open_quotes}spreads.{close_quotes} We have investigated classical PEV of a Drosophila brown transgene affected by a heterochromatic junction {approximately} 60 kb away. PEV was enhanced when the transgene was locally duplicated using P transposase. Successive rounds of P transpose mutagenesis and phenotypic selection produced a series of PEV alleles with differences in phenotype that depended on transgene copy number and orientation. As for other examples of classical PEV, nearby heterochromatin was required for gene silencing. Modifications of classical PEV by alterations at a single site are unexpected, and these ...
The heterokaryotic and vegetative diploid phases of Magnaporthe grisea, a fungal pathogen of grasses, have been characterized. Hyphal tip cells and conidia (vegetative spores) taken from these heterokaryons are auxotrophs with phenotypes identical to one or the other of the parents. M. grisea heterokaryons have completely septate hyphae with a single nucleus per cell. Heterokaryons have been utilized for complementation and dominance testing of mutations that affect nutritional characteristics of the fungus. Heterokaryons growing on minimal medium spontaneously give rise to fast-growing sectors that have the genetic properties expected of unstable heterozygous diploids. In fast-growing sectors, most hyphal tip cells are unstable prototrophs. The conidia collected from fast-growing sectors include stable and unstable prototrophs, as well as auxotrophs that exhibit a wide range of phenotypes, including many recombinant classes. Genetic linkage in ...
Attention deficit disorder (ADHD) is a complex biobehavioral phenotype which affects up to 8% of the general population and often impairs social, academic, and job performance. Its origins are heterogeneous, but a significant genetic component is suggested by family and twin studies. The murine strain, coloboma, displays a spontaneously hyperactive phenotype that is responsive to dextroamphetamine and has been proposed as a genetic model for ADHD. Coloboma is a semi-dominant mutation that is caused by a hemizygous deletion of the SNAP-25 and other genes on mouse chromosome 2q. To test the possibility that the human homolog of the mouse coloboma gene(s) could be responsible for ADHD, we have carried out linkage studies with polymorphic markers in the region syntenic to coloboma (20p11-p12). Five families in which the pattern of inheritance of ADHD appears to be autosomal dominant were studied. Segregation analysis of the traits studied suggested ...
It is shown that a sufficient condition for a model describing the motion of a particle on a coset space to possess a Fundamental Poisson bracket Relation, and consequently charges in involution, is that it must be a symmetric space. The conditions, a Hamiltonian, or any functions of the canonical variables, has to satisfy in order to commute with these charges, are studied. It is show that, for the case of the noncompact symmetric spaces, these conditions lead to an algebraic structure which lays an important role in the construction of conserved quantities.
A study was performed to investigate the size of tongue area and intermaxillary space area, and compare the sexual differences between normal Korean children and adults by introducing planimetric and linear analysis of the lateral cephalograms. The cephalograms were composed of 41 child male aged 10.8, 40 child female aged 10.5, 38 adult male aged 21.3 , and 40 adult female aged 20.8 respectively. In order to study and measure the intermaxillary space area, the following were selected, as reference items: occlusal plane, anterior intermaxillary space height, posterior intermaxillary space height, length of intermaxillary space. Among those reference items anterior intermaxillary space height and posterior intermaxillary space height were perpendicular to the maxillary plane. An index, (Anterior intermaxillary space ...
The present conference on U.S. space transportation systems development discusses opportunities for aerospace students in prospective military, civil, industrial, and scientific programs, current strategic conceptualization and program planning for future U.S. space transportation, the DOD space transportation plan, NASA space transportation plans, medium launch vehicle and commercial space launch services, the capabilities and availability of foreign launch vehicles, and the role of commercial space launch systems. Also discussed are available upper stage systems, future space transportation needs for space science and applications, the trajectory analysis of a low lift/drag-aeroassisted orbit transfer vehicle, possible replacements for the Space Shuttle, LEO to GEO with combined ...
With a pilot electrostatic precipitator having wider plate spacings than usual tests were performed under industrial conditions. In the two-section two-duct pilot precipitator with a precipitation area of 60 m/sup 2/ the plate spacing was increased up to 1,000 mm. As gas velocities values between 0.5 and 2.0 m/s were selected. The precipitator was tested with the flue gases of a coal-fired power station and in the room dedustion of an iron ore sintering plant. Starting with a plate spacing of 250 mm increasing the spacing results initially in a small increase of the precipitation rate. After reaching a maximum the rate decreases and finally with passing a critical spacing it goes below the initial value. Dedusting flue gases the spacing with the maximum and the critical spacing depend on the gas velocity. Cost analyses demonstrate that ...
The present volume on energy and the environment discusses space power requirements, space power systems, space power systems hardware, space radioisotope systems, space solar arrays, space solar cells, space station power, and terrestrial applications of aerospace technology. Attention is given to NASA future space power requirements and issues, the design of a battery charger for the NASA EOS Space Platform, in situ carbon dioxide fixation on Mars, and a preliminary design update of the CRAF/Cassini Power Subsystem. Topics addressed include concentrator testing using projected images, solar power satellites and demonstraton platforms from nonterrestrial materials, a mass sensitivity analysis of lunar orbiting beam power systems, and a power-beaming-based infrastructure for ...
In response to the need of the Strategic Defence Initiative (SDI) and long range space exploration and extra-terrestrial basing by the National Air and Space Administration (NASA), concepts for nuclear power systems in the multi-megawatt levels are being evaluated. The requirements for these power systems are being driven primarily by the need to minimize weight and maximize safety and reliability. This paper discusses the present requirements for space based advanced power systems, technological issues associated with the development of these advanced nuclear power systems, and some of the concepts proposed for generating large amounts of power in space. (author).
A theory of nonunitary-invertible as well as unitary canonical transformations is formulated in the context of Weyl's phase space representations. Exact solutions of the transformation kernels and the phase space propagators are given for the three fundamental canonical maps as fractional-linear, gauge and contact (point) transformations. Under the nonlinear maps a phase space representation is mapped to another phase space representation thereby extending the standard concept of covariance. This extended covariance allows Dirac-Jordan transformation theory to naturally emerge from the Hilbert space representations in the Weyl quantization.
Objectives This paper examines the determinants of the insureds decision to use their health insurance card when seeking outpatient and inpatient health care in Vietnam. Methods Uses Vietnams latest Household Living Standard Survey data and random-intercept logistic regression to assess the influence of the observed individual, household and commune/ward factors on the insureds decision to access health insurance benefits while controlling for the unobserved commune/ward-specific factors. Results Compared to the compulsory enrollees, the voluntary enrollees and the beneficiaries of the Health Care Fund for the Poor are less likely to use their card when seeking inpatient care. An individuals likelihood of accessing insurance benefits varies inversely with income and the level of education,...
The spectre of exclusionary medical service provision, restricted clinic access and physician targeting in sectarian-divided Iraq underscores the crucial and timely need for qualitative research into the inter-relationship between conflict, identity and health. In response, this paper provides a critical ethnography of obstetric service provision and patient access during Shia-Sunni hostilities in Gilgit Town, capital of Pakistans Northern Areas (2005). I analyse how services were embedded in and constrained by sectarian affiliation in ways that detrimentally impacted Sunni women patients and hospital staff, resulting in profoundly diminished clinic access, reduced physician coverage and a higher observed incidence of maternal morbidity and mortality. The paper first situates obstetric med...
Purpose - This paper aims to discuss the procedures and methods developed at Washington State University to digitize and make accessible historic moving images. Design/methodology/approach - The paper describes the selection and the use of low-cost technologies to transfer analog film to digital formats. Issues related to the conversion, description, and online hosting of digital films are also addressed. Findings - Though the steps involved in digitizing film are not trivial, the benefits of access both for the public and archives staff outweigh the expense and labor involved. The procedures described in this paper involve low upfront costs and are sustained through cost recovery fees. Research limitations/implications - The focus of this paper is on managing, describing, and providing on...
Stenting for stenosis of the proximal vertebral artery (VA) is commonly performed via a femoral approach. However, iliofemoral occlusive disease such as arteriosclerosis obliterans sometimes prevents safe transfemoral access. In certain situations where both femoral access and ipsilateral brachial access are difficult because of a concomitant vascular diseases or particular anatomic setting, a contralateral brachial approach using the brachiobrachial pull-through technique may allow efficient and accurate stenting. A case of VA origin symptomatic stenosis successfully treated with stenting using the new pull-through technique from the contralateral brachial artery to the brachial artery on the affected side is described. (orig.)
One of the requirements for a federated information system is interoperability, the ability of one computer system to access and use the resources of another system. This feature is particularly...Full Text Available
Presented here is a case of a young woman, with an undiagnosed osteoid osteoma of the spine, which presented with painful scoliosis in adolescence and was treated by bracing until her accession to adulthood....Full Text Available
... Accession Number : ADB119274. Title : Transdermal Drug Delivery System. Stage 1. Volume 1. Descriptive Note : Final rept. 15 Aug 85-14 Oct 87,. ...
... a woman with a history of PID, perhaps endometriosis -- or some limited vaginal access because of the ... I'm doing an oophorectomy or, you know, endometriosis case where we need to use bipolar sealing ...
...of stations and a number of components, and meta information on air quality monitoring networks and stations. Access the database Producer Europe Environment Agency Content ...of stations and a number of components, and meta information on air quality monitoring networks and stations. Coverage National (Europe) Number of records...
IntroductionResearch is an essential tool in facing the challenges of scaling up interventions and improving access to services. As in many other countries, the translation of research...Full Text Available
BackgroundTelephone quit lines are accessible to many smokers and are used to engage motivated smokers to make quit attempts. Smoking cessation counselling provided via telephone...Full Text Available
The mechanisms controlling seed dormancy in Arabidopsis (Arabidopsis thaliana) have been characterized by proteomics using the dormant (D) accession Cvi originating from the Cape Verde...Full Text Available
... Some OA publishers (such as BMC and PLoS) waive the fee for all researchers affiliated with institutions that have purchased an annual membership. A common misunderstanding is that all OA journals use an \\
A Pd(0)-catalyzed intramolecular Heck-type reaction of oxime ether has been developed, providing convenient access to heterocyclic oximes. PMID:21964259
Skip to Main Content Skip to Main Navigation National Highway Traffic Safety Administration Accessible menu--Sitemap Driving Safety Aggressive Driving Bicycles Child Safety...
...links ensure all of our managed accommodation is easily accessible to both campus sites and our special student arrangement makes travelling on the Metro rapid transit system easily affordable. Our halls are comfortable and they are very reasonable. Download the rents table here Rents 2009-2010 Students living in ...
An evaluation of totally implanted venous access systems inserted in 163 consecutive children with cancer is reported. From 1988 to 1994, 180 subcutaneous ports were inserted in children more than 1...Full Text Available
Metacad is a collection of routines which creates a randomly accessible data structure from Applicon's APPLE-3D data format and supplies a logical method for manipulation of the data structure by a CAD application program.
Electronic personal health records (ePHRs) can potentially maximize access and coordination of health information and improve patient/clinician collaboration, patient self-management, and health outcomes....Full Text Available
The Clinical Summary is a Web-based application for accessing the clinical database at the Massachusetts General Hospital. The application has been developed to give physicians in our health care community...Full Text Available
The concept of "one-stop information shopping" is becoming a reality at Columbia-Presbyterian Medical Center. Our goal is to provide access from a single workstation to clinical, research, and library...Full Text Available
Background and objectives: Few studies have examined health literacy in patients with end stage kidney disease. We hypothesized that inadequate health literacy in a hemodialysis population is common...Full Text Available
... Radon gas concentrations are measured using instruments with calibrations traceable to the UK National Physical Laboratory and PTB, Germany. The primary facility is a 43 m3 walk-in chamber accessed by an airlock. Radon gas is maintained at a level in this chamber that is ...
BackgroundIn patients with Stage 5 Chronic Kidney Disease who require renal replacement therapy a major decision concerns modality choice. However, many patients defer the decision...Full Text Available
The Electronic REference To access In vivo Concentrations (ERETIC) method was applied to 1H HR-MAS spectroscopy. The accuracy, precision, and stability of ERETIC as a quantitative...Full Text Available
...comply with funding body archiving policies, including the policies put in place by the National Institutes of Health, The Wellcome Trust and the Howard Hughes Medical Institute . Delayed Access Select journals provide content to some or all of a journalrsquo;s backfile. For example, articles in ...
BackgroundWebsites of many rogue sellers of medications are accessible through links in email spam messages or via web search engines. This study examined...Full Text Available
For sufficiently cool remote gases, the cylindrical stretched flame shows classical ignition-extinction behavior. For remote gas temperatures close to the adiabatic flame temperature, the flame response is qualitatively different, with negative flame speed solutions which may be physically accessible.
This article compared conceptual and empirical strengths of alternative methods for estimating racial disparities using non-linear models of health care access. Three methods were presented...Full Text Available
ObjectiveThe objective of this study was to determine the contribution of distance to hospitals with cardiac interventional services (CIS) to county age-adjusted myocardial infarction...Full Text Available
Siderophores are essential factors for iron (Fe) acquisition in bacteria during colonization and infection of eukaryotic hosts, which restrain iron access through iron-binding protein, such as lactoferrin...Full Text Available
Cultured mouse or human embryonic stem (ES) cells provide access to all of the genes required to elaborate the fundamental components and physiological systems of a mammalian cell. Chemical or insertional...Full Text Available
There are a range of barriers precluding patients from fully engaging in and benefiting from the spectrum of eHealth interventions developed to support patient access to health information, disease...Full Text Available
Significant research has been devoted to predicting diagnosis, prognosis, and response to treatment using high-throughput assays. Rapid translation into clinical results hinges upon efficient access...Full Text Available
Apr 19, 1996 ... I learned that unlike most nuclear submarines that have 3 or more access routes, the NR-1 has just one hatch. At shallow depths, a rubber ...
...2010-10-01 false Special rules relating to group health plans. 146.145 Section 146.145 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS FOR THE GROUP HEALTH...
...discrimination against participants and beneficiaries based on a health factor. 146.121 Section 146.121 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS FOR THE GROUP HEALTH...
For the safety of astronauts and to ensure the stability and integrity of the genome of microorganisms and plants used in bioregenerative life support systems, it is important to improve our knowledge of the combined action of (space) radiation and microgravity. The SOS-LUX-TOXICITY test, as part of the TRIPLE-LUX project (accepted for flight at Biolab in Columbus on the International Space Station, (ISS)), will provide an estimation of the health risk resulting from exposure of astronauts to the radiation environment of space in microgravity. The project will: (i) increase our knowledge of biological/health threatening action of space radiation and enzymatic DNA repair; (ii) uncover cellular mechanisms of synergistic interaction of microgravity and space radiation; (iii) provide specified...
After mathematicians and physicists had learned that the structure of physical space was not necessarily Euclidean, it became conceivable that the global topological structure of space was non-trivial. In the context of the late 19th century debates on physical space this speculation gave rise to the problem of classifying spaces of constant curvature from a topological point of view. William Kingdon Clifford, Felix Klein and Wilhelm Killing, the latter of whom devoted a substantial amount of work to the topic in the early 1890s, clearly perceived this problem as relevant for both mathematics and natural philosophy (i.e., physics or cosmology). To some extent, a cosmological interest may even be found among those authors who restated the space form problem in more modern terms in the early 20th century, such as Heinz Hopf.
The author presents a detailed and quantitative description of all of the programs, systems, sensors and experiments associated with the next 30 years of space endeavors by the National Aeronautics and Space Administration. Derived from the fifth issue of the NASA Space Systems Technology Model, the missions and payloads are categorized by applications area: solar system exploration, astrophysics, earth sciences, communications, space transportation and utilization of the space environment. Far-term missions are described as opportunity missions and landmark missions, for the distant future. Technology requirements are collected by discipline: power, propulsion, materials, structures, information systems, navigation, guidance and control. Payload technology requirements are organized by instrument sensing range. This information defines in quantitative terms, the opportunities and ...
This book is not a traditional handbook. Engineers in industry need up-to-date, accessible information on the applications of heat and mass transfer. This book is the answer. Contents include: (1) emphasis on applications in thermal design and computer solutions of thermal engineering problems; (2) an introduction to the use of the Second Law of Thermodynamics in analysis, optimization, and economics; (3) information on topics of current interest--in a form convenient and accessible to the average engineer; (4) three chapters of background material--enough to review the basic principles needed to understand specific thermal applications; and (5) extensive treatment of computational tools and numerical analysis.
Polarized antiprotons produced by spin filtering with an internal polarized gas target provide access to a wealth of single- and double-spin observables, thereby opening a window to physics uniquely accessible with the HESR at FAIR. This includes a first measurement of the transversity distribution of the valence quarks in the proton, and a first measurement of the moduli and the relative phase of the time-like electric and magnetic form factors G{sub E,M} of the proton. In polarized and unpolarized pp-bar elastic scattering open questions like the contribution from the odd charge-symmetry Landshoff-mechanism at large |t| and spin-effects in the extraction of the forward scattering amplitude at low |t| can be addressed.
To expand the information base on molecular accessibility in solvent swelled coal, Argonne Premium Coal Samples (APCS) were swelled in polar, basic solvents before and after moisture loss and upon air oxidation. So far studies have been reported on the changes in pore size distribution as a function of temperature when polar basic swelling solvents are used. Additional studies employing EPR spin probe techniques performed on the breaking up of the hydrogen bonding between bedding planes were later confirmed by magnetic resonance imaging at Argonne National Lab and the University of Illinois.
Choosing a medical device is complex and requires a transparent process based on reason, evidence and assessment of prioritized public health needs. Poor choices lead to inappropriate use or non-use of medical devices and a waste of resources.This report suggests how an agenda to improve access to appropriate medical devices could be devised from applying the crucial 4 components - Availability, Accessibility, Appropriateness, and Affordability, to the 15 global high-burden diseases and some cross-cutting issues. The results of this exercise suggest several areas of research necessary to help
During 2009, the Hilton M. Briggs Library, South Dakota State University, went live with MetaLib, a federated search engine from Ex Libris. This paper presents the implementation process, addresses resource accessibility issues, and suggests a number of resources that can be consulted about these issues. Readers can apply similar strategies to projects involving federated search systems, as many implementation projects involve the same basic considerations presented here. The author did not find any studies specifically focused on configurations of MetaLib resources, so this content should be singularly useful.
CERN, DESY, Fermilab and SLAC have joined forces to build INSPIRE, the next-generation HEP information platform offering innovative tools for information discovery and communication. Representing a natural community-based evolution of SPIRES, INSPIRE provides fast access to the entire body of HEP literature. As a subject repository it will host fulltexts of preprints, Open Access journal articles and supplementary material like conference slides and multimedia, enabling novel text- and data mining applications. In the spirit of Web2.0 INSPIRE will also supply tools for collaboration and user-enriched content.
The immense volume of data generated by the suite of instruments on SDO requires new tools for efficient identifying and accessing data that is most relevant to research investigations. We have developed the Heliophysics Events Knowledgebase (HEK) to fill this need. The HEK system combines automated data mining using feature-detection methods and high-performance visualization systems for data markup. In addition, web services and clients are provided for searching the resulting metadata, reviewing results, and efficiently accessing the data. We review these components and present examples of their use with SDO data.
Purpose - The purpose of this paper is to describe the processes and procedures utilized by Jacksonville State University's Houston Cole Library to digitize an oral history collection and provide access to it through the Library's catalog, web presence, and the state-wide digital repository initiative, Alabama Mosaic (see www.alabamamosaic.org). Design/methodology/approach - The paper is based on the Library's experiences in acquiring, digitizing, creating metadata for and making accessible a collection of oral histories. Findings - The paper describes the obstacles overcome, issues encountered, procedures established, and ramifications of the project. Practical implications - Many institutions are currently digitizing unique collections as part of repository initiatives, both institutiona...
The Northwest Foster Care Alumni Study examined the relation between experiences in foster care and depression among young adults who spent at least a year in foster care as adolescents. Results indicate that preparation for leaving foster care, nurturing supports from the foster family, school stability, access to tutoring, access to therapeutic service and support, and a shorter and more stable placement history were associated with a lower probability of depression in young adulthood. Results provide evidence that suggest ways to improve practice to decrease rates of depression among alumni of care. (Contains 2 tables.)
A database has been designed for storing, retrieving and analyzing information about samples, experimental conditions and results obtained by neutron activation analysis and gamma-ray spectrometry. It has been created using Microsoft ACCESS 2002 under a Windows operating system. The database has been designed not only for saving information but also for quality assurance and quality control purposes. The structure of the relational design has been discussed and demonstrated with a new graphical feature of ACCESS 2002 called PIVOTCHART. (author)
Auditory neurons in the superior colliculus (SC) respond preferentially to sounds from restricted directions to form a map of auditory space. The development of this representation is shaped...Full Text Available
An explicit form of the transformation matrix in sin-dimensional space-time is given both for subluminal and superluminal cases, and it is shown how a single formalism can be used for both bradyons and tachyons. (author).
Accompanying rapid developments in hepatic surgery, the number of surgeries and identifications of histological types of primary hepatic space-occupying lesions (PHSOLs) have increased dramatically....Full Text Available
Milstar 2. (USA 115). 60A. Titan IV. Nov. 12, 1995. Install Docking Module on the Mir space. 396 km. Second of 9 planned flights. Space Shuttle Atlantis ...
NASA needed a way to safely strip old paint and thermal protection material from reusable components from the Space Shuttle; to meet this requirement, Marshall Space Flight Center teamed with United Technologies' USBI Company and developed a stripping sys...
A quasi-metric is a distance function which satisfies the triangle inequality but is not symmetric: it can be thought of as an asymmetric metric. The central result of this thesis, developed in Chapter 3, is that a natural correspondence exists between similarity measures between biological (nucleotide or protein) sequences and quasi-metrics. Chapter 2 presents basic concepts of the theory of quasi-metric spaces and introduces a new examples of them: the universal countable rational quasi-metric space and its bicompletion, the universal bicomplete separable quasi-metric space. Chapter 4 is dedicated to development of a notion of the quasi-metric space with Borel probability measure, or pq-space. The main result of this chapter indicates that `a high dimensional quasi-metric space is close to being a metric space'. Chapter 5 investigates the ...
May 1, 2011 ... Onboard Systems Record Unique Videos of Space Missions ... Corporation, An artist's rendering of LCROSS launching toward the Moon .... Station (ISS) as part of the Commercial Orbital Transportation Services program. ...
Operation of an X-ray spectrometer based on a spherical variable-line-spacing (VLS) grating is analyzed using dedicated ray-tracing software allowing fast optimization of the grating parameters and...Full Text Available
Oct 11, 1993 ... Lease: Meadowgreen,3-2.5-2, 2 storyon cuI- ..... also will have the Lunar Landing Training Vehicle elevated over the center of the ...
Feb 23, 2001 ... Florida, as an F-16 weapons separation engineer with .... new era of space-based research aboard the International Space. Station. ..... the Web at: http://www. aiaa.org/calen- dar/index.hfm?cal=1&cfp=1 ...
An inner surface substrate of metal tubes is provided with a single layer of randomly distributed metal bodies bonded to the substrate, spaced from each other, and substantially surrounded by the substrate to form body void space.
This progress report presents a detailed description of the background, technology and application, and Statement of Work for the development of a coal-fired pulse combustor for residential space heating.
Expedition 22 Commander Jeff Williams, aboard the International Space Station 220 miles above Earth, responds to questions posted on YouTube concerning the station's orientation, life in space and the recent butterfly experiment.
The construction of the linear isomorphous and relativistic semigroup, of the Lorentz group and of tachyons was done using a dual pair of space-times, where the sought realization of the parametric semigroup is the semigroup of relativist endomorphisms. The obtained relativistic semigroup of dual space-time transformations possesses certain theoretical-probability properties.
The phase space beam analyzer is a measurement instrument that is applied in laser technology to perform analyses of the spatial and angular distribution of rays. We are interested in this instrument as a means to characterize non-coherent light sources. In this context, a closer look at the tolerances of this optical instrument was considered useful. Having a so-called quadrupole lens as a key element, the phase space beam analyzer is a device that features anamorphic optical properties. To describe these anamorphic properties, recurrence was made to a description by extended ray-transfer matrices. This formalism allows for an analysis of the alignment tolerances of the phase space beam analyzer and facilitates a study of the sensitivities of the instrument. The analysis is complemented using numerical ray tracing.
Mission losses were incurred by an early warning satellite and a Milstar-2 communications satellite when their launch vehicles malfunctioned, the first, ...
Photodiode Scintillation Detector for Anticoincidence Shielding An important goal of space research is to understand the physics involved in the activity of ...
Before working at JPL he was the Chief Engineer for the Milstar Satellite Avionics and several Military space programs. His technical background is in ...
This paper describes the performance of AlGaN/GaN HEMTs with 2.4 #mu#m source-drain spacing. So far these are the smallest source-drain spacing AlGaN/GaN HEMTs which have been implemented with a domestic wafer and domestic process. This paper also compares their performance with that of 4 #mu#m source-drain spacing devices. The former exhibit higher drain current, higher gain, and higher efficiency. It is especially significant that the maximum frequency of oscillation noticeably increased. (semiconductor integrated circuits)
We study a generalization of the classical Riemannian Tonnetz to N-tone equally tempered scales (for all N) and arbitrary triads. We classify all the spaces that result. The torus turns out to be the most common possibility, especially as N grows. Other spaces include 2-simplices, tetrahedra boundaries, and the harmonic strip (in both its cylinder and Mobius band variants). The final and most exotic space we find is something we call a 'circle of tetrahedra boundaries'. These are the Tonnetze for spaces of triads which contain a tritone. They are closely related to Peck's Klein bottle Tonnetz.
... POVs) overseas when space was available. ... information management system launched in 2004. ... Personally Procured Transportation (PPT) system ...
with the support and cooperation of the American Meteorological Society, the Marine Technology Society, the National Aeronautics and Space Administration, the National Institute...
02.10.10 - NASA and Texas Instruments are using the theme of human space exploration to develop digital libraries of math and science problems for high ...
Aluminum electrolytic capacitors have a long history of reliable operation in unattended field sites. However, their use in the expected space applications ...
This report is intended to satisfy two concurrent needs: (1) provide a contract deliverable from Oncorh Consulting to the Washington Department of Fish and Wildlife (WDFW), with emphasis on identification of salient results of value to ongoing Yakima/Klickitat Fisheries Project (YKFP) planning and (2) summarize results of research that have broader scientific relevance. This is the fourth in a series of reports that address reproductive ecological research and monitoring of spring chinook populations in the Yakima River basin. This annual report summarizes data collected between April 1, 2004 and March 31, 2005 and includes analyses of historical baseline data, as well. Supplementation success in the Yakima Klickitat Fishery Project's (YKFP) spring chinook (Oncorhynchus tshawytscha) program is defined as increasing natural production and harvest opportunities, while keeping adverse ecological interactions and genetic impacts within acceptable bounds (Busack et al. 1997). ...
BackgroundThe Prospective Space-Time scan statistic (PST) is widely used for the evaluation of space-time clusters of point event data. Usually a window of cylindrical shape is employed,...Full Text Available
An analysis is presented of the motion of test particles in Goedel's universe. Both geodesical and nongeodesical motions are considered; the accelerations for nongeodesical motions are given. Examples for closed timelike world lines are shown and the dynamical conditions for time travel in Goedel's space-time are discussed. It is shown that these conditions alone do not suffice to exclude time travel in Goedel's space-time. (author).
Given here are the proceedings of the 3rd Space Exploration Initiative (SEI) Technical Interchange. Topics covered include the First Lunar Outpost (FLO), the Lunar Resource Mapper, lunar rovers, lunar habitat concepts, lunar shelter construction analysis, thermoelectric nuclear power systems for SEI, cryogenic storage, a space network for lunar communications, the moon as a solar power satellite, and off-the-shelf avionics for future SEI missions.
Significant temperature differences occur between the internal structure and the outer skin of the Space Shuttle Orbiter as it returns from space. These temperature differences cause important thermal stresses. A finite element model containing thousands of degrees of freedom is used to predict these stresses. A ground test was performed to verify the prediction method. The analysis and test results compare favorably. (orig.).
We apply the framework developed in Target space duality I: general theory. We show that both nonabelian duality and Poisson-Lie duality are examples of the general theory. We propose how the formalism leads to a systematic study of duality by studying few scenarios that lead to open questions in the theory of Lie algebras. We present evidence that there are probably new examples of irreducible target space duality.
A set of nomographs is presented which can be used to estimate the average annual solar fraction for solar space and water heating at a large number of DOD facilities. The solar fraction estimated from the nomograph is in close agreement with F-Chart 3.0 and allows for variation of the following parameters: annual load, collector area, collector transmittance-absorptance coefficient, and collector overall loss coefficient.
The authors study the general features of the dimensional reduction scheme for multi-dimensional spaces of the type M/sup 4/ x S/R, S/R being a symmetric coset space. The properties of the scalar potentials of the reduced theories are investigated and an effective method of explicit calculation of these potentials is elaborated. They consider also a wide class of embeddings of Lie subalgebras into simple Lie algebras resulting in reduced theories of physical interest.
Let ${\\mathcal F}_\\lambda(\\mathbb{S}^n)$ be the space of tensor densities on $\\mathbb{S}^n$ of degree $\\lambda$. We consider this space as an induced module of the nonunitary spherical series of the group $\\mathrm{SO}_0(n+1,1)$ and classify $(\\mathrm{so}(n+1,1),\\mathrm{SO}(n+1))$-sim$unitary submodules of ${\\mathcal F}_\\lambda(\\mathbb{S}^n)$ as a function of $\\lambda$.
Several of the issues of the workshop are addressed from the perspective of a potential Space Station developer and energy wheel user. Systems considerations are emphasized rather than component technology. The potential of energy storage wheel (ESW) concept is discussed. The current status of the technology base is described. Justification for advanced technology development is also discussed. The study concludes that energy storage in wheels is an attractive concept for immediate technology development and future Space Station application.
The periodic mode is analyzed together with two conventional boundary handling modes for particle swarm. By providing an infinite space that comprises periodic copies of original search space, it avoids possible disorganizing of particle swarm that is induced by the undesired mutations at the boundary. The results on benchmark functions show that particle swarm with periodic mode is capable of improving the search performance significantly, by compared with that of conventional modes and other algorithms.
Li shell-model calculation has been made in the isospin formalism in the complete (0 + n)#Planck constant##omega# model space with the assumption of a closed core "4He. The calculation could probably be improved by use of a better effective interaction and increasing shell model space. With the use of faster computer with large memories, the authors are in hope of calculation in spsd shell-model space
The irreducible representations associated with states of dipole symmetry have been calculated for the space groups O/sub h//sup 3/, the space group with the correct symmetry for A-15 phase compounds. Also assembled are the character tables of the O/sub h/3 group. Thus all thedirect interband dipole-transition selection rules for A-15 compounds can easily be determined.
Passive dosimeters for personal and area radiation monitor in space have been developed mainly for dosimetry in low-earth-orbit (LEO) radiation environments of Space Shuttles and the International Space Station. The responses of several dosimeters have been evaluated by heavy ions and also its variation for individual dosimeter element. (author)
Primary dendrite spacings and side-branch coarsening kinetics were examined in specimens of the single-crystal multicomponent commercial superalloy PWA-1480, which were directionally solidified in a psoitive thermal gradient. The experimentally observed dependence of primary dendrite spacings and side-branch coarsening kinetics on growth rate and thermal gradient were in agreement with the behavior predicted by analytical models developed for binary alloys. (orig.).
An S-brane solution with two non-composite electric branes and a set of l scalar fields is considered. The intersection rule for branes corresponds to the Lie algebra A_2. The solution contains five factor spaces with the fifth one interpreted as ``our'' 3-dimensional space. It is shown that there exists a time interval where accelerating expansion of ``our'' 3-dimensional space is compatible with small enough value of effective gravitational ``constant'' variation.
Malformations in farmed fish are a prime research topic as it has a major impact on fish welfare and on the economical value of the product. In this study, the genetic component of spine deformities was estimated in European sea bass, a major species of Mediterranean aquaculture, with the use of a posteriori reconstruction of pedigree with microsatellites. Our population exhibited a very high malformation rate (81%), probably due to intense swimming of fish during pre-growing. The heritability of global spine deformities was evaluated to be 0.21?0.04 on the underlying scale (0.33?0.06 for lordosis, 0.13?0.04 for scoliosis). Deformities scored by an internal or external examination turned out to be genetically the same trait (genetic correlations>0.9), although phenotypic correlations were ...
Biological control agents can be more effective if their populations are genetically diverse, particularly when the target invasive plant comprises a range of genotypes with different susceptibilities and occurs across various microclimates. We report on the use of an efficient approach to find, in the native range, diverse isolates of a rust fungus for biological control. An outdoor trap garden containing various clones of invasive European blackberry (Rubus fruticosus agg.) collected in Australia, each with a different DNA phenotype, was established in France. Within 4?weeks of establishment, the leaf-rust fungus Phragmidium violaceum was recovered from all clones in the garden. Molecular analyses of eight recovered and purified isolates of the fungus from the garden revealed that they w...
Most heat shock proteins (Hsps) function as molecular chaperones that help organisms to cope with stress. Although the best empirical evidence is related to heat shock, there is evidence that Hsps and their encoding genes are involved in resistance to other ecologically relevant types of stresses such as those imposed by high population density. We quantified density-dependent gene expression of large (i.e. Hsp40, Hsc70 and Hsp90) and small (Hsp20.5, Hsp20.6 and Hsp20.7) heat shock genes in neural tissue of fifth-instar nymphs of the Australian plague locust, Chortoicetes terminifera, using reverse transcription-quantitative PCR. Locusts are of particular interest when studying the influence of stress induced by high population density since they show an extreme form of phenotypic plastici...
Severe affective and behavioral dysregulation, labeled as severe mood dysregulation (SMD), is a widely spread phenomenon among adolescent psychiatric patients. This phenotype constitutes severe impairment across multiple settings, including various symptoms, such as non-episodic anger, mood instability, and hyperarousal. Moreover, SMD patients often show depression and reduced need for sleep. Despite a lifetime prevalence of 3.3%, systematic research is still scarce, and treatments that have been established do not account for the range of symptoms present in SMD. Considering the circadian dysfunctions, two hormones, melatonin and cortisol, are essential. When these hormones are dysregulated, the circadian rhythm gets out of synchrony. Since evidence is emerging showing that the worse the ...
Abstract Septins are highly conserved cytoskeletal GTP-binding proteins implicated in numerous cellular processes from apoptosis to vesicle trafficking. Septins have been associated with leukemia and solid tumor malignancies, including breast, ovarian, and prostate. We previously reported that high SEPT9_i1 expression in human mammary epithelial cell lines (HMECs) led to malignant cellular phenotypes such as increased cell proliferation, invasiveness, motility, and genomic instability. Our goal here was to better understand how SEPT9_i1 expression might contribute to genomic instability and malignant progression. First, we confirmed that even transient expression of SEPT9_i1 was sufficient to increase aneuploidy in HMECs. We then analyzed SEPT9_i1 by immunoprecipitation and immunofluoresce...
Abstract Tumor necrosis factor (TNF)- is a pro-inflammatory cytokine associated with psoriasis pathogenesis. Anti-TNF- therapies are effective in psoriasis. A significant weight gain has been reported in patients treated with anti-TNF- agents. The aim of the present study was to evaluate the body composition changes in psoriatic patients receiving anti-TNF- therapies according with disease phenotype. Forty patients affected with psoriasis were followed up for 24 weeks and divided into two groups: psoriasis vulgaris (PsO) and psoriatic arthritis (PsA). Anthropometric, blood biochemical, body composition parameters, resting metabolic rate, and disease activity indexes were measured at baseline and at week 24. After 24 weeks of anti-TNF- administration, the disease activity indexes and concen...
Survival and growth of terrestrial plants is negatively affected by complete submergence. This is mainly the result of hampered gas exchange between plants and their environment, since gas diffusion is severely reduced in water compared with air, resulting in O2 deficits which limit aerobic respiration. The continuation of photosynthesis could probably alleviate submergence-stress in terrestrial plants, but its potential under water will be limited as the availability of CO2 is hampered. Several submerged terrestrial plant species, however, express plastic responses of the shoot which may reduce gas diffusion resistance and enhance benefits from underwater photosynthesis. In particular, the plasticity of the flooding-tolerant terrestrial species Rumex palustris turned out to be remarkable,...
Abstract A method to grow the halophilic archaeon Haloferax volcanii in microtiter plates has been optimized and now allows the parallel generation of very reproducible growth curves. The doubling time in a synthetic medium with glucose is around 6-h. The method was used to optimize glucose and casamino acid concentrations, to clarify carbon source usage and to analyze vitamin dependence. The characterization of osmotolerance revealed that after a lag phase of 24-h, H. volcanii is able to grow at salt concentrations as low as 0.7-M NaCl, much lower than the 1.4-M NaCl described as the lowest concentration until now. The application of oxidative stresses showed that H. volcanii exhibits a reaction to paraquat that is delayed by about 10-h. Surprisingly, only one of two amino acid auxotrophi...
Recycling of carbon by the photorespiratory pathway involves enzymatic steps in the chloroplast, mitochondria, and peroxisomes. Most of these reactions are essential for plants growing under ambient CO2 concentrations. However, some disruptions of photorespiratory metabolism cause subtle phenotypes in plants grown in air. For example, Arabidopsis thaliana lacking both of the peroxisomal malate dehydrogenase genes (pmdh1pmdh2) or hydroxypyruvate reductase (hpr1) are viable in air and have rates of photosynthesis only slightly lower than wild-type plants. To investigate how disruption of the peroxisomal reduction of hydroxypyruvate to glycerate influences photorespiratory carbon metabolism we analyzed leaf gas exchange in A. thaliana plants lacking peroxisomal HPR1 expression. In addition, b...
The authors have shown that toxicity of paraquat for Escherichia coli is increased over 1-fold in strains defective in the biosynthesis of spermidine compared to isogenic strains containing spermidine. The increased sensitivity of these spermidine-deficient mutants to paraquat is eliminated by growth in medium containing spermidine or by endogenous supplementation of spermidine by the use of a speE"+D"+ plasmid. No paraquat toxicity is seen in the absence of oxygen, even in amine-deficient strains, indicating that superoxide is the agent responsible for the increased toxicity. However, the specific mechanisms responsible for the increased paraquat toxicity in the spermidine-deficient mutants remain to be determined. The marked sensitivity to paraquat of E. coli deficient in spermidine is of particular interest, since such mutants have no other phenotypic properties that can be easily assayed. This increased sensitivity has been used as the basis of a convenient ...
To determine whether PKH26 labeling affects the morphologies, phenotypes, proliferation, and secretion abilities of human umbilical mesenchymal stromal cells (HUMSCs) were investigated. Isolated HUMSCs were labeled with PKH26, and cell morphology was observed under microscope. Cell cycle, apoptotic cell death, expression of PKH26, and the proliferation rate were evaluated. Additionally, fluorescence intensity of PKH26 labeling at different passage times was quantified. There were no detectable differences in cell morphology, cell growth, and proliferation rate after PKH26 labeling. In addition, fluorescence intensity of PKH26 labeling was gradually reduced with increase of the passage times. The PKH26 labeling disappeared after passage six times. In summary, PKH26 labeling is a safe and ef...
Objective: Evidence from adults suggests that changes in thyroid function are associated with the development of bipolar disorder (BD) and severe mood dysregulation. A dysregulation profile based on the Child Behavior Checklist (CBCL-DP) describes a phenotype with severe mood problems in youth. The present study investigated whether altered thyroid functioning in youths is associated with the severe mood dysregulation symptoms characterized by the CBCL-DP. Methods: We analyzed the thyroid function data from 262 children and adolescents (n=262 for serum TSH, n=148 for free triiodothyronine [fT3] and n=153 for free thyroxine [fT4]) with their CBCL-DP composite score. We created and compared high CBCL-DP and low CBCL-DP subgroups with regard to their serum TSH, fT3 and fT4 concentrations as w...
Toadlets of the genus Brachycephalus are endemic to the Atlantic rainforests of southeastern and southern Brazil. The 14 species currently described have snout-vent lengths less than 18mm and are thought to have evolved through miniaturization: an evolutionary process leading to an extremely small adult body size. Here, we present the first comprehensive phylogenetic analysis for Brachycephalus, using a multilocus approach based on two nuclear (Rag-1 and Tyr) and three mitochondrial (Cyt b, 12S, and 16S rRNA) gene regions. Phylogenetic relationships were inferred using a partitioned Bayesian analysis of concatenated sequences and the hierarchical Bayesian method (BEST) that estimates species trees based on the multispecies coalescent model. Individual gene trees showed conflict and also va...
Fibroblast growth factor (FGF) signaling has been shown to regulate lung epithelial development but its influence on mesenchymal differentiation has been poorly investigated. To study the role of mesenchymal FGF signaling in the differentiation of the mesenchyme and its impact on epithelial morphogenesis, we took advantage of Fgfr2c+/? mice, which due to a splicing switch express Fgfr2b in mesenchymal tissues and manifest Apert syndrome-like phenotypes. Using a set of in vivo and in vitro studies, we show that an autocrine FGF10?FGFR2b signaling loop is established in the mutant lung mesenchyme, which has several consequences. It prevents the entry of the smooth muscle progenitors into the smooth muscle cell (SMC) lineage and results in reduced fibronectin and elastin deposition. Levels of...
BackgroundPeritoneal metastasis occurs in up to 30% of patients with gastric cancer. The aim of this experimental study is to develop and validate a novel ex vivo model of the human peritoneum to better identify factors involved in the development of peritoneal metastasis in order to improve its management and prognosis. MethodsPeritoneal discs harvested from hernia sacs obtained at inguinal hernia surgery were suspended in media using Teflon rings. Viability of the tissue was investigated using MTS assay, light and scanning electron microscopy (LM and SEM) over 72 h. To assess validity of the model, phenotypic changes in tumor cells were investigated. Changes in matrix metalloproteinases (MMP)-2 and -9 activities in HGC and AGS gastric adenocarcinoma cells after co-culture were investigat...
Increased levels of epidermal growth factor receptor have been reported in a variety of tumors, including pulmonary squamous cell carcinomas in man. The purpose of this study was to determine if increased levels of epidermal growth factor (EGFR) were present in lung tumors from Beagle dogs that had been exposed to "2"3"9PuO_2- Using immunohistochemical techniques, sections from 17 lung tumors were examined for the presence of EGFR. Seven of the tumors were strongly positive for EGFR; the remainder of the tumors and the normal lung sections were negative. The positive immunostaining could not be correlated with the histologic phenotype of the tumors. Work is in progress to determine the level of EGFR in preneoplastic, proliferative epithelial foci in the Iung. (author)
Myotonic dystrophy type 1 (DM1) is characterized by both a premature appearance of age-related phenotypes and multiple organ involvement, which affects skeletal and smooth muscle as well as the eye, heart, central nervous system, and endocrine system. Although erectile dysfunction (ED) is a frequent complaint in patients with DM1, it has not been investigated in great depth. Hypogonadism, which is reported to be one of the physical causes of ED in the general population, frequently occurs in DM1. We planned this case?control study to evaluate the relationship between hypogonadism, as defined by the sexual hormone profile (FSH, LH, testosterone (T) and prolactin) and ED, as assessed by means of an internationally validated self-administered questionnaire (IIEF). DM1 patients had significant...
Optimization of nonviral gene delivery typically focuses on the design of particulate carriers that are endowed with desirable membrane targeting, internalization, and endosomal escape properties. Topographical control of cell transfectability, however, remains a largely unexplored parameter. Emerging literature has highlighted the influence of cell-topography interactions on modulation of many cell phenotypes, including protein expression and cytoskeletal behaviors implicated in endocytosis. Using high-throughput screening of primary human dermal fibroblasts cultured on a combinatorial library of microscale topographies, we have demonstrated an improvement in nonviral transfection efficiency for cells cultured on dense micropit patterns compared to smooth substrates, as verified with flow...
Prepulse inhibition (PPI) is a measure of sensorimotor gating, a pre-attentional inhibitory brain mechanism that filters extraneous stimuli. Prepulse inhibition is correlated with measures of cognition and executive functioning, and is considered an endophenotype of schizophrenia and other psychiatric illnesses in which patients show PPI impairments. As a first step toward identifying genes that regulate PPI, we performed a quantitative trait locus (QTL) screen of PPI phenotypes in a panel of mouse chromosome substitution strains (CSSs). We identified five CSSs with altered PPI compared with the host C57BL/6J strain: CSS-4 exhibited decreased PPI, whereas CSS-10, -11, -16 and -Y exhibited higher PPI compared with C57BL/6J. These data indicate that A/J chromosomes 4, 10, 11, 16 and Y harbor...
Occurrence of genetic variants during micropropagation is occasionally encountered when the cultures are maintained in vitro for long period. Therefore, the micropropagated multiple shoots of Vanilla planifolia Andrews developed from axillary bud explants established 10 years ago were used to determine somaclonal variation using random amplified polymorphic DNA (RAPD) and intersimple sequence repeats markers (ISSR). One thousand micro-plants were established in soil of which 95 plantlets (consisting of four phenotypes) along with the mother plant were subjected to genetic analyses using RAPD and ISSR markers. Out of the 45 RAPD and 20 ISSR primers screened, 30 RAPD and 7 ISSR primers showed 317 clear, distinct and reproducible band classes resulting in a total of 30 115 bands. However, no ...
Research on hematological disorders relies on suitable animal models. We retrospectively evaluated the use of the hematological parameters hematocrit (HCT), hemoglobin (HGB), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), red blood cell count (RBC), white blood cell count (WBC), and platelet count (PLT) in the phenotype-driven Munich N-ethyl-N-nitrosourea (ENU) mouse mutagenesis project as parameters for the generation of novel animal models for human diseases. The analysis was carried out on more than 16,000 G1 and G3 offspring of chemically mutagenized inbred C3H mice to detect dominant and recessive mutations leading to deviations in the levels of the chosen parameters. Identification of animals exhibiting altered valu...
Objective: Atherosclerosis is an inflammatory disease, modulated by plaque stabilizing and de-stabilizing cell populations such as infiltrating monocytes and vascular smooth muscle cells (vSMCs). Transcription factors regulating proliferation and differentiation of atherosclerosis relevant cell types are of interest in this context. The forkhead box transcription factor FoxP1 modulates monocyte differentiation. We studied FoxP1 expression in atherosclerotic tissue, correlated FoxP1 expression with plaque characteristics and identified associations between FoxP1 and plaque proteins. Methods: 116 Atherosclerotic plaques from carotid endarterectomy samples were histologically classified (fibrous, fibroatheromatous, atheromatous) and subjected to semi-quantitative protein analysis. Macrophage,...
The expression of motor activity levels in response to novel situations is under complex genetic and environmental control. Several genetic loci have been implicated in the regulation of this behavioral phenotype, but their relationship to epigenetic and epistatic interactions is relatively unknown. Here, we report on a quantitative trait locus (QTL) on mouse chromosome 1 for novelty-induced motor activity in the open field, using chromosome substitution strains derived from a high active host strain (C57BL/6J) and a low active donor strain (A/J). The QTL for open field (horizontal distance moved) peaked at the location of Kcnj9, however, QTL detection was initially masked by an interplay of both grandparent genetic origin and genetic co-factors influencing behavior on chromosome 1. Our fi...
Studies were carried out on the decolorization of textile azo dyes by newly isolated halophilic and halotolerant bacteria. Among the 27 strains of halophilic and halotolerant bacteria isolated from effluents of textile industries, three showed remarkable ability in decolorizing the widely utilized azo dyes. Phenotypic characterization and phylogenetic analysis based on 16S rDNA sequence comparisons indicate that these strains belonged to the genus Halomonas. The three strains were able to decolorize azo dyes in a wide range of NaCl concentration (up to 20%w/v), temperature (25-40degreeC), and pH (5-11) after 4 days of incubation in static culture. They could decolorize the mixture of dyes as well as pure dyes. These strains also readily grew in and decolorized the high concentrations of dy...
Abstract Previous research has established the comorbidity of adult Attention-Deficit Hyperactivity Disorder (ADHD) with different personality disorders including Borderline Personality Disorder (BPD). The association between adult ADHD and BPD has primarily been investigated at the phenotypic level and not yet at the genetic level. The present study investigates the genetic and environmental contributions to the association between borderline personality traits (BPT) and ADHD symptoms in a sample of 7,233 twins and siblings (aged 18-90 years) registered with the Netherlands Twin Register and the East Flanders Prospective Twin Survey (EFPTS) . Participants completed the Conners' Adult ADHD Rating Scales (CAARS-S:SV) and the Personality Assessment Inventory-Borderline Features Scale (PAI-BO...
Assembly of icosahedral capsids of proper size and symmetry is not understood. Residue F170 in bacteriophage P22 coat protein is critical for conformational switching during assembly. Substitutions at this site cause assembly of tubes of hexamerically arranged coat protein. Intragenic suppressors of the ts phenotype of F170A and F170K coat protein mutants were isolated. Suppressors were repeatedly found in the coat protein telokin-like domain at position 285, which caused coat protein to assemble into petite procapsids and capsids. Petite capsid assembly strongly correlated to the side chain volume of the substituted amino acid. We hypothesize that larger side chains at position 285 torque the telokin-like domain, changing flexibility of the subunit and intercapsomer contacts. Thus, a sing...
SNAP25 occurs on chromosome 20p12.2, which has been linked to schizophrenia in some samples, and recently linked to latent classes of psychotic illness in our sample. SNAP25 is crucial to synaptic functioning, may be involved in axonal growth and dendritic sprouting, and its expression may be decreased in schizophrenia. We genotyped 18 haplotype-tagging SNPs in SNAP25 in a sample of 270 Irish high-density families. Single marker and haplotype analyses were performed in FBAT and PDT. We adjusted for multiple testing by computing q values. Association was followed up in an independent sample of 657 cases and 411 controls. We tested for allelic effects on the clinical phenotype by using the method of sequential addition and 5 factor-derived scores of the OPCRIT. Nine of 18 SNPs had P values <...
This Chapter develops a realist information-theoretic interpretation of the nonclassical features of quantum probabilities. On this view, what is fundamental in the transition from classical to quantum physics is the recognition that \\emph{information in the physical sense has new structural features}, just as the transition from classical to relativistic physics rests on the recognition that space-time is structurally different than we thought. Hilbert space, the event space of quantum systems, is interpreted as a kinematic (i.e., pre-dynamic) framework for an indeterministic physics, in the sense that the geometric structure of Hilbert space imposes objective probabilistic or information-theoretic constraints on correlations between events, just as the geometric structure of Minkowski space in special relativity imposes spatio-temporal kinematic constraints on events. The ...