WorldWideScience

Sample records for aca supplementation strain

  1. Performance of the auxotrophic Saccharomyces cerevisiae BY4741 as host for the production of IL-1β in aerated fed-batch reactor: role of ACA supplementation, strain viability, and maintenance energy

    Zueco Jesus

    2009-12-01

    Full Text Available Abstract Background Saccharomyces cerevisiae BY4741 is an auxotrophic commonly used strain. In this work it has been used as host for the expression and secretion of human interleukin-1β (IL1β, using the cell wall protein Pir4 as fusion partner. To achieve high cell density and, consequently, high product yield, BY4741 [PIR4-IL1β] was cultured in an aerated fed-batch reactor, using a defined mineral medium supplemented with casamino acids as ACA (auxotrophy-complementing amino acid source. Also the S. cerevisiae mutant BY4741 Δyca1 [PIR4-IL1β], carrying the deletion of the YCA1 gene coding for a caspase-like protein involved in the apoptotic response, was cultured in aerated fed-batch reactor and compared to the parental strain, to test the effect of this mutation on strain robustness. Viability of the producer strains was examined during the runs and a mathematical model, which took into consideration the viable biomass present in the reactor and the glucose consumption for both growth and maintenance, was developed to describe and explain the time-course evolution of the process for both, the BY4741 parental and the BY4741 Δyca1 mutant strain. Results Our results show that the concentrations of ACA in the feeding solution, corresponding to those routinely used in the literature, are limiting for the growth of S. cerevisiae BY4741 [PIR4-IL1β] in fed-batch reactor. Even in the presence of a proper ACA supplementation, S. cerevisiae BY4741 [PIR4-IL1β] did not achieve a high cell density. The Δyca1 deletion did not have a beneficial effect on the overall performance of the strain, but it had a clear effect on its viability, which was not impaired during fed-batch operations, as shown by the kd value (0.0045 h-1, negligible if compared to that of the parental strain (0.028 h-1. However, independently of their robustness, both the parental and the Δyca1 mutant ceased to grow early during fed-batch runs, both strains using most of the

  2. Affordable Care Act (ACA)

    Social Security Administration — The Affordable Care Act (ACA) is a federal statute enacted with a goal of increasing the quality and affordability of health insurance. Through a web service, CMS...

  3. Tryptophan provision by dietary supplementation of a Bacillus subtilis mutant strain in piglets

    Torres-Pitarch, A; Nielsen, B.; Canibe, Nuria;

    2015-01-01

    Supplementing Bacillus (B.) subtilis mutants selected to overproduce a specific amino acid (AA) may be an alternative method to provide essential AA in pig diets. Two experiments on a B. subtilis strain selected to overproduce Trp were conducted using 8-kg pigs fed Trp-deficient diets for 20 d. B....... subtilis were supplied in a low or high dose in Experiments 1 and 2, respectively. The Trp-deficient diet (0.15 SID Trp:Lys) reduced (p < .05) both gain and feed intake of piglets compared to the positive control diet (0.17 SID Trp:Lys). Supplementation of the B. subtilis strain was not able to...... counterbalance the Trp deficiency in any of the two experiments. No effect of B. subtilis supplementation to piglet diets was observed on the plasma AA profile. In conclusion, this mutant strain of B. subtilis was not able to compensate a Trp deficiency in the tested doses....

  4. The effect of multivitamin-multimineral supplementation on the health status of inbred Wistar and spontaneously hypertensive rat strains

    Rosemarie U. Höfler; Mahendra L. Channa; Anand Nadar

    2016-01-01

    The nutraceutical industry has proliferated in recent years, with the most popular form of supplementation being the multivitamin-multimineral (MVMM) supplement. In the animal health sector, supplement use has also expanded. The objective of this study was to determine the effects of MVMM supplementation, beneficial or otherwise, on the general health status of the spontaneously hypertensive rat (SHR) strain, an animal model used in hypertension research. A commercially prepared MVMM suppleme...

  5. Influência da suplementação de creatina na capacidade funcional de pacientes com Insuficiência Cardíaca Influence of creatine supplementation on the functional capacity of patients with Heart Failure

    Ana Paula Perillo Ferreira Carvalho

    2012-07-01

    Full Text Available FUNDAMENTO: A Insuficiência Cardíaca (IC é uma síndrome complexa, marcada pela intolerância ao esforço e perda da capacidade funcional. OBJETIVO: Avaliar a capacidade funcional dos pacientes com IC suplementados com creatina. MÉTODOS: Estudo prospectivo, randomizado, duplo cego. Foram randomizados em dois grupos 33 pacientes com IC, com idade > 18 anos, sexo masculino, classes funcionais II a IV. O grupo experimental (G CRE, n = 17 foi suplementado com creatina com dose de 5 g por dia durante seis meses. E o grupo placebo (G PLA, n = 16 recebeu 5 g de maltodextrina por dia durante o mesmo período de tempo. Ambos os grupos foram submetidos a avaliação da capacidade funcional por meio da ergoespirometria e teste de caminhada de seis minutos (TC6 pré e pós-intervenção. O modelo estatístico Ancova e a correlação de Pearson foram utilizados na análise dos grupos e nas formas de tratamento. RESULTADOS: Das variáveis avaliadas na ergoespirometria, o volume de oxigênio pico (VO2 pico, limiar anaeróbio (LA e o pulso de oxigênio (pulso de O2 não apresentaram diferenças significativas entre os grupos (P>0,05. No TC6 não houve diferença significativa na distância percorrida. CONCLUSÃO: A suplementação de creatina em pacientes com IC não promoveu melhora significativa na capacidade funcional.BACKGROUND: Heart failure (HF is a complex syndrome characterized by intolerance to exertion and reduced functional capacity. OBJECTIVE: To assess the functional capacity of patients with HF and supplemented with creatine. METHODS: Prospective, randomized, double-blind study. Thirty-three male patients over the age of 18 years with functional class II to IV HF were randomized into two groups as follows: the experimental group (CRE, n = 17, supplemented with 5 g/day of creatine for six months; and the placebo group (PLA, n = 16, receiving 5 g/day of maltodextrin for that same period. Both groups underwent functional capacity assessment by

  6. EFFECT OF DIETARY SUPPLEMENTATION OF MULTI-STRAIN PROBIOTIC ON BROILER GROWTH PERFORMANCE

    M. I. Anjum, A. G. Khan, A. Azim and M. Afzal1

    2005-01-01

    Full Text Available The effects of a multi-strain probiotic (protexin on broiler growth performance, carcass parameters and economic efficiency were studied. For this purpose, 270 day-old broiler chicks were randomly divided into three experimental groups A, B and C, with 90 chicks in each group having three replicates. Group A was fed commercial broiler diet without supplementation of protexin (control and groups B and C were fed diets containing protexin 100 and 110g/t in starter and 50 and 55 g/t in finisher diets, respectively. Feed and water were offered ad libitum. The results showed that weight gain and feed conversion ratio were significantly (p<0.05 improved in chicks fed on protexin-supplemented diets compared to control diets. Weight gain of the chicks fed on diet C was significantly (p<0.05 better than chicks on diet B. Feed conversion ratio was non-significantly different in both the protexin-supplemented groups. Differences in feed intake, meat composition, dressing percentage and empty organ weights among all the diets were non-significant. However, abdominal fat content was reduced significantly (P<0.05 in supplemented groups. The study suggests that protexin supplementation is beneficial for better weight gains, feed efficiency and economic efficiency in broiler chicks.

  7. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants.

    Berni Canani, Roberto; Sangwan, Naseer; Stefka, Andrew T; Nocerino, Rita; Paparo, Lorella; Aitoro, Rosita; Calignano, Antonio; Khan, Aly A; Gilbert, Jack A; Nagler, Cathryn R

    2016-03-01

    Dietary intervention with extensively hydrolyzed casein formula supplemented with Lactobacillus rhamnosus GG (EHCF+LGG) accelerates tolerance acquisition in infants with cow's milk allergy (CMA). We examined whether this effect is attributable, at least in part, to an influence on the gut microbiota. Fecal samples from healthy controls (n=20) and from CMA infants (n=19) before and after treatment with EHCF with (n=12) and without (n=7) supplementation with LGG were compared by 16S rRNA-based operational taxonomic unit clustering and oligotyping. Differential feature selection and generalized linear model fitting revealed that the CMA infants have a diverse gut microbial community structure dominated by Lachnospiraceae (20.5±9.7%) and Ruminococcaceae (16.2±9.1%). Blautia, Roseburia and Coprococcus were significantly enriched following treatment with EHCF and LGG, but only one genus, Oscillospira, was significantly different between infants that became tolerant and those that remained allergic. However, most tolerant infants showed a significant increase in fecal butyrate levels, and those taxa that were significantly enriched in these samples, Blautia and Roseburia, exhibited specific strain-level demarcations between tolerant and allergic infants. Our data suggest that EHCF+LGG promotes tolerance in infants with CMA, in part, by influencing the strain-level bacterial community structure of the infant gut. PMID:26394008

  8. The effect of multivitamin-multimineral supplementation on the health status of inbred Wistar and spontaneously hypertensive rat strains.

    Höfler, Rosemarie U; Channa, Mahendra L; Nadar, Anand

    2016-01-01

    The nutraceutical industry has proliferated in recent years, with the most popular form of supplementation being the multivitamin-multimineral (MVMM) supplement. In the animal health sector, supplement use has also expanded. The objective of this study was to determine the effects of MVMM supplementation, beneficial or otherwise, on the general health status of the spontaneously hypertensive rat (SHR) strain, an animal model used in hypertension research. A commercially prepared MVMM supplement was given tri-weekly via oral dosing for 8 weeks to two groups of seven adult female SHR and Wistar rats. Their corresponding control groups were dosed with deionised water only. Systolic and diastolic blood pressure, fasting blood glucose, growth rate and food and water intake were measured weekly. At the end of 8 weeks, the animals were euthanased and a full blood profile, urine sodium to potassium ratio, blood urea nitrogen levels and total plasma cholesterol was measured for all groups. The results indicated that growth rate was higher for the SHR supplemented group. Supplementation also decreased diastolic blood pressure in both Wistar and SHR groups and increased red blood cell count and decreased total cholesterol in the SHR group. No adverse effects on the general health status of the animals were observed. MVMM supplementation may therefore be useful in aiding growth and delaying the onset of hypertension and its effects. It may also assist in the longevity of the breeding stock of SHR rats. PMID:27381881

  9. Development of minimal fermentation media supplementation for ethanol production using two Saccharomyces cerevisiae strains.

    Tropea, Alessia; Wilson, David; Cicero, Nicola; Potortì, Angela G; La Torre, Giovanna L; Dugo, Giacomo; Richardson, David; Waldron, Keith W

    2016-05-01

    Ethanol production by fermentation is strongly dependent on media composition. Specific nutrients, such as trace elements, vitamins and nitrogen will affect the physiological state and, consequently, the fermentation performance of the micro-organism employed. The purpose of this study has been to assess the highest ethanol production by a minimal medium, instead of the more complex nutrients supplementation used during alcoholic fermentation. All fermentation tests were carried out using a microwell plate reader to monitor the processes. Two Saccharomyces cerevisiae strains (NCYC 2826 and NCYC 3445) were tested using three nitrogen sources, supplied with different vitamin and salts. The results show that solutions made of urea phosphate, KCl, MgSO4·7H2O, Ca-panthothenate, biotin allowed an ethanol yield of 22.9 and 23.4 g/L for strain NCYC 2826 and NCYC 3445, respectively, representing 90 and 92% of the theoretical yield. All tests were carried out using glucose as common reference carbon source. PMID:26469871

  10. The effect of multivitamin-multimineral supplementation on the health status of inbred Wistar and spontaneously hypertensive rat strains

    Rosemarie U. Höfler

    2016-02-01

    Full Text Available The nutraceutical industry has proliferated in recent years, with the most popular form of supplementation being the multivitamin-multimineral (MVMM supplement. In the animal health sector, supplement use has also expanded. The objective of this study was to determine the effects of MVMM supplementation, beneficial or otherwise, on the general health status of the spontaneously hypertensive rat (SHR strain, an animal model used in hypertension research. A commercially prepared MVMM supplement was given tri-weekly via oral dosing for 8 weeks to two groups of seven adult female SHR and Wistar rats. Their corresponding control groups were dosed with deionised water only. Systolic and diastolic blood pressure, fasting blood glucose, growth rate and food and water intake were measured weekly. At the end of 8 weeks, the animals were euthanased and a full blood profile, urine sodium to potassium ratio, blood urea nitrogen levels and total plasma cholesterol was measured for all groups. The results indicated that growth rate was higher for the SHR supplemented group. Supplementation also decreased diastolic blood pressure in both Wistar and SHR groups and increased red blood cell count and decreased total cholesterol in the SHR group. No adverse effects on the general health status of the animals were observed. MVMM supplementation may therefore be useful in aiding growth and delaying the onset of hypertension and its effects. It may also assist in the longevity of the breeding stock of SHR rats.Keywords: multivitamin-multimineral (MVMM supplementation; hypertension; spontaneously hypertensive rats (BRU; Wistar rats; breeding stock

  11. Malondialdeído e troponina I cardíaca em equinos da raça Puro Sangue Árabe submetidos ao exercício e à suplementação com vitamina E Malondialdehyde and cardiac troponin I in Arabian horses subjected to exercise and vitamin E supplementation

    Letícia Andreza Yonezawa

    2010-06-01

    Full Text Available Para avaliar o efeito do exercício físico, do treinamento e da suplementação com vitamina E sobre o malondialdeído (MDA e a troponina I cardíaca (cTnI séricos, foram utilizados 16 equinos da raça Puro Sangue Árabe, sem treinamento, divididos em dois grupos de oito: controle e suplementado com vitamina E. Ambos os grupos foram submetidos a provas de exercício progressivo em esteira de alta velocidade inclinada a +7%, antes (P1 e após (P2 o período de treinamento de 20 dias. Foram determinadas as concentrações séricas de MDA, vitamina E e cTnI e realizou-se o eletrocardiograma de repouso antes e após as provas P1 e P2. Os resultados sugerem a ocorrência do estresse oxidativo ocasionado pelo exercício, determinado por meio do aumento de MDA sérico. Em alguns animais, houve um discreto aumento de cTnI associado à detecção de complexos ventriculares prematuros, mas que não representou lesão cardíaca expressiva. Não houve efeito do treinamento sobre o estresse oxidativo. Portanto, é possível concluir que o exercício físico progressivo promoveu a lipoperoxidação nessas condições, que não foi prevenida pela suplementação com vitamina E nem pelo treinamento, mas não foi suficiente para causar uma lesão cardíaca significativa.To evaluate the effect of exercise, training and vitamin E supplementation on serum malondialdehyde (MDA and cardiac troponin I (cTnI, sixteen adult untrained Arabian horses were divided into 2 groups of 8 animals each, control and supplemented with vitamin E. Both groups had incremental exercise tests performed on a high-speed treadmill at a +7% slope, before (P1 and after (P2 a training period of 20 days. Serum concentrations of MDA, vitamin E and cTnI, and resting electrocardiogram were performed before and after P1 and P2. Results suggested that oxidative stress was induced by exercise as measured by serum MDA increase. In some animals, there was a subtle increase in cTnI concentration

  12. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants

    Berni Canani, Roberto; Sangwan, Naseer; Stefka, Andrew T.; Nocerino, Rita; Paparo, Lorella; Aitoro, Rosita; Calignano, Antonio; Khan, Aly A.; Gilbert, Jack A.; Nagler, Cathryn R.

    2015-01-01

    Dietary intervention with extensively hydrolyzed casein formula supplemented with Lactobacillus rhamnosus GG (EHCF+LGG) accelerates tolerance acquisition in infants with cow's milk allergy (CMA). We examined whether this effect is attributable, at least in part, to an influence on the gut microbiota. Fecal samples from healthy controls (n=20) and from CMA infants (n=19) before and after treatment with EHCF with (n=12) and without (n=7) supplementation with LGG were compared by 16S rRNA-based ...

  13. Insuficiencia cardíaca y diabetes

    Jorge Thierer

    2006-01-01

    La prevalencia de la insuficiencia cardíaca y la diabetes continúa creciendo. Ambas están fuertemente asociadas. La diabetes es un fuerte predictor de aparición de insuficiencia cardíaca. Las razones son la presencia de enfermedad coronaria y los trastornos metabólicos vinculados con la resistencia a la insulina que generan disfunción contráctil. Los pacientes con insuficiencia cardíaca que son diabéticos tienen peor evolución. Los Betabloqueantes, vasodilatadores y los inhibidores de la en...

  14. Effects of nutritional supplementation with l-arginine on repair of injuries due to muscle strain: experimental study on rats

    Lauren Izabel Medeiros Couto

    2015-08-01

    Full Text Available ABSTRACTOBJECTIVE: To evaluate the influence of oral supplementation with arginine on regeneration of injuries due to straining of the anterior tibial muscle of rats. METHODS: Twenty-four Wistar rats of weight 492.5 ± 50.45 g were used. Injuries were induced through straining the anterior tibial muscles. The rats were separated into three groups of eight rats each. In the untreated group (UTG, after induction of injuries, the rats were observed for 24 h. In the simulation group (SG and the arginine group (AG respectively, the rats received isotonic saline solution and arginine solution via direct gavage, over a seven-day period. At the end of the period, blood samples were collected for serum evaluations of creatine kinase (CK, lactic dehydrogenase (LDH, aspartate aminotransferase (AST and C-reactive protein (CRP. The right and left anterior tibial muscles were resected for histopathological evaluations on the muscle injuries, investigating edema, hemorrhage and disorganization or morphometric alteration of the muscle fibers. The tissue repair was investigated in terms of proliferation of adipose tissue, angiogenesis and collagen fibers. The ANOVA and Student's tmethods were used and p≤ 0.05 was taken to be statistically significant. RESULTS: In the serum evaluations, the AG showed lower CK assay values and higher AST values. In the histopathological evaluation, the UTG presented edema and hemorrhage compatible with injuries due to strain; the SG presented edema and hemorrhage with proliferation of adipose tissue and collagen fibers; and the AG presented not only the findings of the SG but also, especially, intense angiogenesis. CONCLUSION: Oral supplementation with arginine did not cause any significant metabolic alterations that would contraindicate its use and it induced angiogenesis during the repair of muscles injured due to strain.

  15. Levan-Producing Leuconostoc citreum Strain BD1707 and Its Growth in Tomato Juice Supplemented with Sucrose.

    Han, Jin; Xu, Xiaofen; Gao, Caixia; Liu, Zhenmin; Wu, Zhengjun

    2016-03-01

    A levan-producing strain, BD1707, was isolated from Tibetan kefir and identified as Leuconostoc citreum. The effects of carbon sources on the growth of L. citreum BD1707 and levan production in tomato juice were measured. The changes in pH, viable cell count, sugar content, and levan yield in the cultured tomato juice supplemented with 15% (wt/vol) sucrose were also assayed. L. citreum BD1707 could synthesize more than 28 g/liter of levan in the tomato juice-sucrose medium when cultured at 30°C for 96 h. Based on the monosaccharide composition, molecular mass distribution, Fourier transform infrared (FTIR) spectra, and nuclear magnetic resonance (NMR) spectra, the levan synthesized by L. citreum BD1707 was composed of a linear backbone consisting of consecutive β-(2→6) linked d-fructofuranosyl units, with an estimated average molecular mass of 4.3 × 10(6) Da. PMID:26682858

  16. Dietary supplementation of a mixture of Lactobacillus strains enhances performance of broiler chickens raised under heat stress conditions

    Faseleh Jahromi, Mohammad; Wesam Altaher, Yassir; Shokryazdan, Parisa; Ebrahimi, Roohollah; Ebrahimi, Mahdi; Idrus, Zulkifli; Tufarelli, Vincenzo; Liang, Juan Boo

    2015-11-01

    High ambient temperature is a major problem in commercial broiler production in the humid tropics because high producing broiler birds consume more feed, have higher metabolic activity, and thus higher body heat production. To evaluate the effects of two previously isolated potential probiotic strains (Lactobacillus pentosus ITA23 and Lactobacillus acidophilus ITA44) on broilers growing under heat stress condition, a total of 192 chicks were randomly allocated into four treatment groups of 48 chickens each as follows: CL, birds fed with basal diet raised in 24 °C; PL, birds fed with basal diet plus 0.1 % probiotic mixture raised in 24 °C; CH, birds fed with basal diet raised in 35 °C; and PH, birds fed with basal diet plus 0.1 % probiotic mixture raised in 35 °C. The effects of probiotic mixture on the performance, expression of nutrient absorption genes of the small intestine, volatile fatty acids (VFA) and microbial population of cecal contents, antioxidant capacity of liver, and fatty acid composition of breast muscle were investigated. Results showed that probiotic positively affected the final body weight under both temperature conditions (PL and PH groups) compared to their respective control groups (CL and CH). Probiotic supplementation numerically improved the average daily gain (ADG) under lower temperature, but significantly improved ADG under the higher temperature (P < 0.05) by sustaining high feed intake. Under the lower temperature environment, supplementation of the two Lactobacillus strains significantly increased the expression of the four sugar transporter genes tested (GLUT2, GLUT5, SGLT1, and SGLT4) indicating probiotic enhances the absorption of this nutrient. Similar but less pronounced effect was also observed under higher temperature (35 °C) condition. In addition, the probiotic mixture improved bacterial population of the cecal contents, by increasing beneficial bacteria and decreasing Escherichia coli population, which could be

  17. Dietary supplementation of a mixture of Lactobacillus strains enhances performance of broiler chickens raised under heat stress conditions

    Faseleh Jahromi, Mohammad; Wesam Altaher, Yassir; Shokryazdan, Parisa; Ebrahimi, Roohollah; Ebrahimi, Mahdi; Idrus, Zulkifli; Tufarelli, Vincenzo; Liang, Juan Boo

    2016-07-01

    High ambient temperature is a major problem in commercial broiler production in the humid tropics because high producing broiler birds consume more feed, have higher metabolic activity, and thus higher body heat production. To evaluate the effects of two previously isolated potential probiotic strains ( Lactobacillus pentosus ITA23 and Lactobacillus acidophilus ITA44) on broilers growing under heat stress condition, a total of 192 chicks were randomly allocated into four treatment groups of 48 chickens each as follows: CL, birds fed with basal diet raised in 24 °C; PL, birds fed with basal diet plus 0.1 % probiotic mixture raised in 24 °C; CH, birds fed with basal diet raised in 35 °C; and PH, birds fed with basal diet plus 0.1 % probiotic mixture raised in 35 °C. The effects of probiotic mixture on the performance, expression of nutrient absorption genes of the small intestine, volatile fatty acids (VFA) and microbial population of cecal contents, antioxidant capacity of liver, and fatty acid composition of breast muscle were investigated. Results showed that probiotic positively affected the final body weight under both temperature conditions (PL and PH groups) compared to their respective control groups (CL and CH). Probiotic supplementation numerically improved the average daily gain (ADG) under lower temperature, but significantly improved ADG under the higher temperature ( P < 0.05) by sustaining high feed intake. Under the lower temperature environment, supplementation of the two Lactobacillus strains significantly increased the expression of the four sugar transporter genes tested (GLUT2, GLUT5, SGLT1, and SGLT4) indicating probiotic enhances the absorption of this nutrient. Similar but less pronounced effect was also observed under higher temperature (35 °C) condition. In addition, the probiotic mixture improved bacterial population of the cecal contents, by increasing beneficial bacteria and decreasing Escherichia coli population, which could be

  18. 77 FR 65006 - Air Cargo Advance Screening (ACAS) Pilot Program

    2012-10-24

    ... December 5, 2003, CBP published a final rule in the Federal Register (68 FR 68140) to effectuate the... secure VPN connection with CBP that the ACAS pilot participant is willing to set up. ACAS...

  19. The cytotoxic effects a of ACA1 on human melanoma cell line

    R. Yaraie

    2006-01-01

    Full Text Available Background and purpose: Different methods such as surgery, chemotherapy, radiotherapy, hormone therapy and immunotherapy are used for treatment of melanoma cancer. Unfortunately they don't always have desirable results and they may have unfavorable side effects. Researchers try to find new, more effective drugs with low side effects. In this study we evaluated the cytotoxic effect of ACA-1, a water extract of a traditional Iranian medicinal herbs on a melanoma cell line SKMEL-3.Materials and Methods: The SKMEL3 cell line was obtained from Pasture institute, Tehran, Iran and cultured in RPMI media supplemented with 10% FBS. Equal number of cells were added to a 96 well microplate and were incubated with various doses of ACA1 (5,2,1,0.2,0.1,0.05,0.02 and 0.01 mg/ml for 24, 48 and 72 hours in parallel. The cytotoxic effects of the drug was evaluated using MTT assay.Results: The Results showed that ACA1 has significant cytotoxic effects with dose and time dependent manner on SKMEL3. The optimum dose (5 mg/ml showed 47% cytotoxicity in 24 h, 65% cytotoxicity in 48 h and 71% cytotoxicity in 72 h. Conclusion: Based on the results of this research, ACA1 is a suitable candidate for chemotherapy of melanoma patients. Further studies are necessary in order to find effective drugs, their effects on other cell lines and approved in vivo models and clinical trials.

  20. Influence of Supplemental Dietary Poultry Fat on the Yolk Characteristics of Commercial Layers Inoculated Before or at the Onset of Lay with F-Strain Mycoplasma gallisepticum

    The effects of F-strain Mycoplasma gallisepticum (FMG) inoculation and 1.5 % supplemental dietary poultry fat (PF) on the egg yolk characteristics of commercial layers between 24 and 58 wk of age were investigated. Sham and FMG inoculations were administered at 12 (before lay) and 22 (early in lay)...

  1. Insuficiencia cardíaca y diabetes

    Jorge Thierer

    2006-01-01

    Full Text Available La prevalencia de la insuficiencia cardíaca y la diabetes continúa creciendo. Ambas están fuertemente asociadas. La diabetes es un fuerte predictor de aparición de insuficiencia cardíaca. Las razones son la presencia de enfermedad coronaria y los trastornos metabólicos vinculados con la resistencia a la insulina que generan disfunción contráctil. Los pacientes con insuficiencia cardíaca que son diabéticos tienen peor evolución. Los Betabloqueantes, vasodilatadores y los inhibidores de la enzima convertidora ejercen una influencia favorable, en tanto que el uso de glitazonas todavía es controversial. La insuficiencia cardíaca puede a su vez generar diabetes, debido a la activación del sistema nervioso simpático y al efecto del tratamiento. La comprensión adecuada de estos hechos es fundamental para tomar decisiones correctas y mejorar la suerte de los pacientes.

  2. Effect of isolate of ruminal fibrolytic bacterial culture supplementation on fibrolytic bacterial population and survivability of inoculated bacterial strain in lactating Murrah buffaloes

    Brishketu Kumar

    2013-02-01

    Full Text Available Aim: The present study was conducted to evaluate the effect of bacterial culture supplementation on ruminal fibrolytic bacterial population as well as on survivability of inoculated bacterial strain in lactating Murrah buffaloes kept on high fibre diet. Materials and Methods: Fibrolytic bacterial strains were isolated from rumen liquor of fistulated Murrah buffaloes and live bacterial culture were supplemented orally in treatment group of lactating Murrah buffaloes fed on high fibre diet to see it's effect on ruminal fibrolytic bacterial population as well as to see the effect of survivability of the inoculated bacterial strain at three different time interval in comparison to control group. Results: It has been shown by real time quantification study that supplementation of bacterial culture orally increases the population of major fibre degrading bacteria i.e. Ruminococcus flavefaciens, Ruminococcus albus as well as Fibrobacter succinogenes whereas there was decrease in secondary fibre degrading bacterial population i.e. Butyrivibrio fibrisolvens over the different time periods. However, the inoculated strain of Ruminococcus flavefaciens survived significantly over the period of time, which was shown in stability of increased inoculated bacterial population. Conclusion: The isolates of fibrolytic bacterial strains are found to be useful in increasing the number of major ruminal fibre degrading bacteria in lactating buffaloes and may act as probiotic in large ruminants on fibre-based diets. [Vet World 2013; 6(1.000: 14-17

  3. Effect of Probiotic Strain Enterococcus faecium M74 Supplementation on the Carcass Parameters of Different Hybrid Combination Chickens

    Ján Weis

    2011-05-01

    Full Text Available The aim of the present study was to evaluate the effect of addition of Enterococcus faecium M74 in drinking water on performance and carcass characteristics of broiler chickens. Totally 120 chickens (60 of hybrid Hybro, 60 of Ross 308 were divided to two groups. Experimental chickens of Hybro (n=30 and Ross 308 (n=30 received a probiotic preparation in drinking water from day 1 to day 42 with concentration of 2x109 CFU of Enterococcus faecium M 74 in 1 g of nutrient medium with dextrose. The control group of Hybro (n=30 and Ross 308 (n=30 received water in same total amount as experimental group without any additives. The feeding period lasted 42 days. In case of Hybro, we showed higher effect of Enterococcus faecium M74 supplementation on slaughter weight (1807.51 vs. 1929.08 g; P0.05 in comparison with Ross 308 (2126.63 vs. 2199.31g; P>0.05. Differences in percentage of valuable parts (thigh and breast and carcass yield of Hybro and Ross 308 were not statistically significant (P>0.05 by addition of probiotic On the end of fattening, Ross 308 broiler chickens fed diet with probiotic strain Enterococcus faecium had significantly less (P<0.05 abdominal fat than those fed without the probiotic. In Hybro broiler chickens we recorded not significant difference between groups (P>0.05.

  4. Long-term effects of dietary supplementation with an essential oil mixture on the growth and laying performance of two layer strains

    Mehmet Pamukçu; Metin Çabuk; Mehmet Bozkurt; Kamil Küçükyilmaz; Ahmet Alçiçek; Abdullah U. Çatli

    2012-01-01

    One thousand two hundred 1-day-old Lohmann LSL white and Lohmann Brown layer chickens were fed diets supplemented with either an antibiotic growth promoter (AGP) or an herbal essential oil mixture (EOM) till 58 wk of age to reveal the long-term effects of those additives on growth, performance and wholesome egg quality parameters. The study was arranged in a 2x3 factorial design with two layer strains and three feed additive regimens. Thus, the layer birds of both strains were randomly assign...

  5. Caquexia cardíaca Cardiac cachexia

    Alberto Miján

    2006-05-01

    Full Text Available La insuficiencia cardíaca de carácter crónico (ICC, en especial si afecta al corazón derecho, ocasiona con frecuencia malnutrición. Si esta es grave y se unen otros componentes, puede producirse caquexia cardíaca. Esta se asocia a mayor morbilidad y menor supervivencia de los pacientes que la padecen. Las causas de la caquexia cardíaca son diversas, en general asociadas a mantener balance energético negativo, surgiendo cada vez mayor evidencia que apoya un origen multifactorial de la misma. Entre otros, factores neurohormonales, inflamatorios, inmunológicos y metabólicos se superponen en el paciente con ICC, pudiendo producir afectación y deterioro de diversos órganos o sistemas, incluyendo la caquexia cardíaca. Esta puede definirse de diversos modos que, en general, concretan una reducción de peso en un tiempo definido o de estructuras corporales, ya que esta entidad afecta tanto a la masa magra o celular activa, como a los tejidos adiposo y óseo "osteoporosis. De todos ellos, el deterioro más acusado puede observarse en el tejido muscular esquelético, tanto a nivel estructural como funcional, no quedando exento el corazón de su afectación. Respecto del tratamiento, este debe basarse en la evidencia científica disponible. La valoración del estado nutricional de todo paciente con ICC es obligada, debiendo intervenir nutricionalmente ante MEP o riesgo de desarrollarla. En esta situación, mas si existe caquexia cardíaca, es necesaria una modificación de la dieta oral en energía y calidad de la misma, debiendo valorar la indicación de nutrición artificial específica complementaria o alternativa. Asimismo, cada vez adquiere mayor fuerza causal el papel beneficioso del ejercicio físico moderado, así como de la modulación por determinados fármacos de las alteraciones metabólicas e inflamatorias observadas en la caquexia cardíaca, que incluyen una respuesta favorable a nivel funcional y estructural del paciente con ICC

  6. Insuficiencia cardíaca neonatal

    Pastor Durán, Xavier

    1986-01-01

    PROTOCOLOS TERAPEUTICOS. INSUFICIENCIA CARDIACA NEONATAL. 1. CONCEPTO La insuficiencia cardíaca (IC) en el recién nacido suele manifestarse de forma global salvo en contadas ocasiones (ciertas cardiopatías congénitas). Las causas pueden ser múltiples, desde problemas hidroelectrolíticos hasta infecciones, pasando por la yatrogenia de la sobrecarga hídrica debida a una mala prescripción de las perfusiones. Un intento de clasificación puede ser el siguiente...

  7. Promoting Systemic Change through the ACA Advocacy Competencies

    Toporek, Rebecca L.; Lewis, Judith A.; Crethar, Hugh C.

    2009-01-01

    In 2003, the American Counseling Association (ACA) adopted the ACA Advocacy Competencies (J. A. Lewis, M. S. Arnold, R. House, & R. L. Toporek, 2002) to provide guidance to counselors and acknowledge advocacy as an ethical aspect of service to clients. This article provides a foundation for this special section by sharing a historical perspective…

  8. Long-term effects of dietary supplementation with an essential oil mixture on the growth and laying performance of two layer strains

    Abdullah U. Çatli

    2012-01-01

    Full Text Available One thousand two hundred 1-day-old Lohmann LSL white and Lohmann Brown layer chickens were fed diets supplemented with either an antibiotic growth promoter (AGP or an herbal essential oil mixture (EOM till 58 wk of age to reveal the long-term effects of those additives on growth, performance and wholesome egg quality parameters. The study was arranged in a 2x3 factorial design with two layer strains and three feed additive regimens. Thus, the layer birds of both strains were randomly assigned to the three dietary treatments, i.e., standard basal diet (control, control with AGP (specifically, avilamycin, 10 mg/kg diet and control with EOM (24 mg/kg diet. The data regarding egg production were recorded between 22 to 58 weeks of age. Neither the dietary treatments nor the bird strain influenced the body weight and mortality of the birds in both the growing and laying period. AGP or EOM supplementation to the laying hen diet significantly increased the egg production rate and egg weight as compared to the control  diet alone, but egg mass output, feed consumption, and feed conversion ratio were not effected  by the dietary treatments. Neither dietary treatment created any statistically significantly differences in egg quality parameters with the exception of Haugh unit. The research findings have confirmed the beneficial effects of supplementation with feed-grade EOM on the laying rate and egg weight of both white and brown layers. Indeed, EOM, being a novel feed additive natural origin, proved to be as efficacious as AGP in promoting egg yield.

  9. Long-term effects of dietary supplementation with an essential oil mixture on the growth and laying performance of two layer strains

    Mehmet Pamukçu

    2012-01-01

    Full Text Available One thousand two hundred 1-day-old Lohmann LSL white and Lohmann Brown layer chickens were fed diets supplemented with either an antibiotic growth promoter (AGP or an herbal essential oil mixture (EOM till 58 wk of age to reveal the long-term effects of those additives on growth, performance and wholesome egg quality parameters. The study was arranged in a 2x3 factorial design with two layer strains and three feed additive regimens. Thus, the layer birds of both strains were randomly assigned to the three dietary treatments, i.e., standard basal diet (control, control with AGP (specifically, avilamycin, 10 mg/kg diet and control with EOM (24 mg/kg diet. The data regarding egg production were recorded between 22 to 58 weeks of age. Neither the dietary treatments nor the bird strain influenced the body weight and mortality of the birds in both the growing and laying period. AGP or EOM supplementation to the laying hen diet significantly increased the egg production rate and egg weight as compared to the control diet alone, but egg mass output, feed consumption, and feed conversion ratio were not effected by the dietary treatments. Neither dietary treatment created any statistically significantly differences in egg quality parameters with the exception of Haugh unit. The research findings have confirmed the beneficial effects of supplementation with feed-grade EOM on the laying rate and egg weight of both white and brown layers. Indeed, EOM, being a novel feed additive natural origin, proved to be as efficacious as AGP in promoting egg yield.

  10. EHS & LCA assessment for 7-ACA synthesis

    Henderson, Richard K; Jiménez-González, Concepción; Preston, Chris;

    2008-01-01

    study were a chemical synthetic process and a two-enzyme catalyzed process, both starting from the potassium salt of cephalosporin C. Cradle-to-gate life cycle impact estimations were performed using the Fast Life Cycle Assessment of Synthetic Chemistry (FLASC™) tool and following modular gate......-to-gate methodology. The results compare the synthetic efficiency, environment, health, safety, and life cycle metrics for a mature chemical process and a more recent but less developed enzymatic process for making 7-ACA. The chemical process has a higher yield, but a significantly lower reaction mass efficiency and...... environmental impact, mainly derived from the production of raw materials. In comparison to the enzyme-catalyzed process, the chemical process uses approximately 60% more energy, about 16% more mass (excluding water), has double the greenhouse gas (GHG) impact, and about 30% higher photochemical ozone creation...

  11. Variabilidade da Frequência Cardíaca

    Roque, Juliano Miguel Amado

    2009-01-01

    Este trabalho teve como objectivo estudar a variabilidade da frequência cardíaca e quais as causas que condicionam essa mesma variabilidade. Verificámos que a frequência cardíaca está dependente do sistema nervoso autónomo apesar de o coração apresentar uma actividade intrínseca capaz de fazer contrair o músculo cardíaco. O sistema nervoso autónomo tem a capacidade para aumentar a frequência cardíaca através do sistema nervoso simpático e de reduzir essa mesma frequência cardíaca através do s...

  12. Influence of Supplemental Dietary Poultry Fat, Phytase, and 25-Hydroxycholecalciferol on the Performance of Commercial Layers Inoculated Before or at the Onset of Lay with F-Strain Mycoplasma gallisepticum

    The effects of 2 levels of supplemental dietary poultry fat (PF) and the combination of PF, phytase (PHY) and 25-hydroxycholecalciferol (D3) on the performance of commercial layers inoculated with F-strain Mycoplasma gallisepticum (FMG) were investigated in 2 trials. Sham and FMG inoculations were ...

  13. Effects of Supplemental Dietary Phytase and 25-Hydroxycholecalciferol on the Performance Characteristics of Commercial Layers Inoculated before or at the Onset of Lay with the F-Strain of Mycoplasma gallisepticum

    The effects of dietary supplementation with phytase and 25-hydroxycholecalciferol on the performance characteristics of commercial layers that were inoculated prelay (12 wk of age) or at the onset of lay (22 wk of age) with F-strain Mycoplasma gallisepticum were assessed. Experimental layer diets, w...

  14. Influence of Supplemental Dietary Poultry Fat on the Digestive and Reproductive Organ Characteristics of Commercial Layers Inoculated Before or at the Onset of Lay with F-Strain Mycoplasma gallisepticum

    The effects of F-strain Mycoplasma gallisepticum (FMG) inoculation and 1.5 % supplemental dietary poultry fat (PF) on the digestive and reproductive organ characteristics of commercial layers at 58 wk of age were investigated. Sham and FMG inoculations were administered at 12 (before lay) and 22 (e...

  15. Influence of supplemental dietary poultry fat, phytase, and 25-hydroxycholecalciferol on the blood characteristics of commercial layers inoculated before or at the onset of lay with F-strain Mycoplasma gallisepticum

    The effects of 2 supplemental levels of dietary poultry fat (PF) and the combination of PF, phytase (PHY) and 25-hydroxycholecalciferol [25(OH)D] on the blood characteristics of commercial layers inoculated with F-strain Mycoplasma gallisepticum (FMG) were investigated in 2 trials. Sham and FMG ino...

  16. Design of a variant surface antigen-supplemented microarray chip for whole transcriptome analysis of multiple Plasmodium falciparum cytoadherent strains, and identification of strain-transcendent rif and stevor genes

    Bozdech Zbynek

    2011-06-01

    Full Text Available Abstract Background The cytoadherence of Plasmodium falciparum is thought to be mediated by variant surface antigens (VSA, encoded by var, rif, stevor and pfmc-2tm genes. The last three families have rarely been studied in the context of cytoadherence. As most VSA genes are unique, the variability among sequences has impeded the functional study of VSA across different P. falciparum strains. However, many P. falciparum genomes have recently been sequenced, allowing the development of specific microarray probes for each VSA gene. Methods All VSA sequences from the HB3, Dd2 and IT/FCR3 genomes were extracted using HMMer software. Oligonucleotide probes were designed with OligoRankPick and added to the 3D7-based microarray chip. As a proof of concept, IT/R29 parasites were selected for and against rosette formation and the transcriptomes of isogenic rosetting and non-rosetting parasites were compared by microarray. Results From each parasite strain 50-56 var genes, 125-132 rif genes, 26-33 stevor genes and 3-8 pfmc-2tm genes were identified. Bioinformatic analysis of the new VSA sequences showed that 13 rif genes and five stevor genes were well-conserved across at least three strains (83-100% amino acid identity. The ability of the VSA-supplemented microarray chip to detect cytoadherence-related genes was assessed using P. falciparum clone IT/R29, in which rosetting is known to be mediated by PfEMP1 encoded by ITvar9. Whole transcriptome analysis showed that the most highly up-regulated gene in rosetting parasites was ITvar9 (19 to 429-fold up-regulated over six time points. Only one rif gene (IT4rifA_042 was up-regulated by more than four fold (five fold at 12 hours post-invasion, and no stevor or pfmc-2tm genes were up-regulated by more than two fold. 377 non-VSA genes were differentially expressed by three fold or more in rosetting parasites, although none was as markedly or consistently up-regulated as ITvar9. Conclusions Probes for the VSA of

  17. The "ACA Code of Ethics": Articulating Counseling's Professional Covenant

    Ponton, Richard F.; Duba, Jill D.

    2009-01-01

    The "ACA Code of Ethics" (American Counseling Association, 2005) is an articulation of the ever-changing relationship between counseling professionals and society. It provides clear parameters of behaviors to meet the changing needs of the people counselors are called to serve. This article reviews the 2005 "Code" as both a statement of counselor…

  18. Patologia cardíaca associada à tirotoxicose

    Cruz, Maria Raquel Marques Rodrigues Moreira da

    2009-01-01

    O trabalho que se apresenta resulta de uma revisão bibliográfica acerca da patologia cardíaca associada à tirotoxicose, que pretende reunir a informação mais relevante acerca do tema. O objectivo deste trabalho é avaliar em que medida as doenças cardíacas se encontram associadas a doenças da tiróide, nomeadamente à tirotoxicose. A glândula tiroideia é um dos maiores órgãos especializados em função endócrina do corpo humano. As hormonas tiroideias contêm 59-65% de iodo. ...

  19. ACA phase calibration scheme with the ALMA water vapor radiometers

    Asaki, Yoshiharu; Matsushita, Satoki; Morita, Koh-Ichiro; Nikolic, Bojan

    2012-09-01

    In Atacama Large Millimeter/submillimeter Array (ALMA) commissioning and science verification we have conducted a series of experiments of a novel phase calibration scheme for Atacama Compact Array (ACA). In this scheme water vapor radiometers (WVRs) devoted to measurements of tropospheric water vapor content are attached to ACA’s four total-power array (TP Array) antennas surrounding the 7 m dish interferometer array (7 m Array). The excess path length (EPL) due to the water vapor variations aloft is fitted to a simple two-dimensional slope using WVR measurements. Interferometric phase fluctuations for each baseline of the 7 m Array are obtained from differences of EPL inferred from the two-dimensional slope and subtracted from the interferometric phases. In the experiments we used nine ALMA 12-m antennas. Eight of them were closely located in a 70-m square region, forming a compact array like ACA. We supposed the most four outsiders to be the TP Array while the inner 4 antennas were supposed to be the 7 m Array, so that this phase correction scheme (planar-fit) was tested and compared with the WVR phase correction. We estimated residual root-mean-square (RMS) phases for 17- to 41-m baselines after the planar-fit phase correction, and found that this scheme reduces the RMS phase to a 70 - 90 % level. The planar-fit phase correction was proved to be promising for ACA, and how high or low PWV this scheme effectively works in ACA is an important item to be clarified.

  20. Application of serum anticardiolipin antibody (ACA) determination with ELISA for detection of intra-uterine growth retardation (IUGR)

    Objective: To explore the interrelationship between presence of serum ACA and development of IUGR. Methods: Serum ACA contents were examined with ELISA in 5330 apparently normal pregnant women. The placentae in 16 pregnancies with IUGR and positive ACA were examined with immunofluorescence microscopy. Results: Among the 5330 pregnant women there were 144 with positive ACA (2.70%), in whom there were 22 IUGR cases (22/144, 15.28% ). The rate of IUGR in the remaining ACA negative women was only 1.77% (92/5186), the difference being very significant (P<0.01 ). ACA IgG was positive in 5 of the IUGR neonates, All the placental tissues examined with immunofluorescence microscopy showed positive immunoglobulin fluorescence antibody and complement discoloration. Conclusion: Positive ACA is one of the causative factors of development of IUGR and determination of ACA in pregnant women was helpful for early detection of IUGR. (authors)

  1. New Mandates and Imperatives in the Revised "ACA Code of Ethics"

    Kaplan, David M.; Kocet, Michael M.; Cottone, R. Rocco; Glosoff, Harriet L.; Miranti, Judith G.; Moll, E. Christine; Bloom, John W.; Bringaze, Tammy B.; Herlihy, Barbara; Lee, Courtland C.; Tarvydas, Vilia M.

    2009-01-01

    The first major revision of the "ACA Code of Ethics" in a decade occurred in late 2005, with the updated edition containing important new mandates and imperatives. This article provides interviews with members of the Ethics Revision Task Force that flesh out seminal changes in the revised "ACA Code of Ethics" in the areas of confidentiality,…

  2. A Critical Examination of the Assessment Analysis Capabilities of OCLC ACAS

    Lyons, Lucy E.

    2005-01-01

    Over 500 libraries have employed OCLC's iCAS and its successor Automated Collection Assessment and Analysis Services (ACAS) as bibliometric tools to evaluate monograph collections. This examination of ACAS reveals both its methodological limitations and its feasibility as an indicator of collecting patterns. The results can be used to maximize the…

  3. Caquexia associada à insuficiência cardíaca

    Marina Politi Okoshi

    2013-05-01

    Full Text Available Pacientes com insuficiência cardíaca frequentemente desenvolvem estado de caquexia, que constitui fator independente de redução da sobrevida. Caquexia pode ser diagnosticada quando ocorre perda de peso corporal maior que 6% do peso habitual, na ausência de outras doenças. Embora sua fisiopatologia não esteja completamente esclarecida, vários fatores parecem estar envolvidos, como diminuição da ingestão alimentar, anormalidades do trato gastrointestinal, ativação imunológica e neuro-hormonal e alteração da relação entre processos anabólicos e catabólicos. Como não há terapia específica para a caquexia associada à insuficiência cardíaca, o tratamento baseia-se no suporte nutricional, bloqueio neuro-hormonal, controle do edema e anemia e exercícios físicos. Fármacos com propriedades imunomodulatórias e anabólicas encontram-se em investigação clínica e experimental.

  4. Signature of MoU between CERN and Australian Collaboration for Accelerator Science (ACAS); Roger Rassool, ACAS Director; Mark Boland, ACAS Deputy Director; Jean-Pierre Delahaye, CLIC Project Leader; in the presence of Rolf Heuer, Director-General and Emmanuel Tsesmelis, Adviser for Australia

    Maximilien Brice

    2010-01-01

    Signature of MoU between CERN and Australian Collaboration for Accelerator Science (ACAS); Roger Rassool, ACAS Director; Mark Boland, ACAS Deputy Director; Jean-Pierre Delahaye, CLIC Project Leader; in the presence of Rolf Heuer, Director-General and Emmanuel Tsesmelis, Adviser for Australia

  5. Calcium supplements

    ... this page: //medlineplus.gov/ency/article/007477.htm Calcium supplements To use the sharing features on this page, please enable JavaScript. WHO SHOULD TAKE CALCIUM SUPPLEMENTS? Calcium is an important mineral for the ...

  6. The effect of supplementation with polysaccharides, nucleotides, acidifiers and Bacillus strains in fish meal and soy bean based diets on growth performance in juvenile turbot (Scophthalmus maximus)

    Fuchs (geb. Hemsing), Vanessa; Schmidt, Jan; Slater, Matthew James; Zentek, Jürgen; Buck, Bela H.; Steinhagen, Dieter

    2015-01-01

    The investigation and application of a wide range of dietary supplements, such as probiotics, prebiotic and other additives, are increasingly popular in aquaculture research and practice. To date few studies have attempted to quantify the value of commercially available additives in improving growth performance of juvenile turbot (Scophthalmus maximus) and in compensating potential growth reduction resulting from high levels of plant protein (PP) in carnivorous fish diets. Two experiments ...

  7. Sports Supplements

    ... sports supplements often use persuasive before and after pictures that make it look easy to get a muscular, toned body. But the goal of supplement advertisers is to make money by selling more supplements, and many claims may be misleading. Teens and kids may seem like an easy sell ...

  8. Ein empirischer Validitätsvergleich der ACA, des ASE und des PCPM

    Meissner, Martin; Decker, Reinhold; Adam, Nadine

    2011-01-01

    The increasing complexity of many products makes high demands on methods used for measuring consumer preferences. In such cases, practitioners frequently use Adaptive Conjoint Analysis (ACA). However, compositional approaches also proved to be efficient. Recently, Srinivasan and Netzer (2011...

  9. Stochastic estimation of the Frobenius norm in the ACA convergence criterion

    Heldring, Alexander; Úbeda Farré, Eduard; Rius Casals, Juan Manuel

    2015-01-01

    The adaptive cross approximation (ACA) algorithm has been used in many fast Integral Equation solvers for electromagnetic Radiation and Scattering problems. It efficiently computes a low rank approximation to the interaction matrix between mutually distant parts of a scattering object. The ACA is an iterative algorithm that needs an accurate and efficient convergence criterion. The evaluation of this criterion may consume a considerable part of the computational resources. This communication ...

  10. Glutamine supplementation

    Wernerman, Jan

    2011-01-01

    Intravenous glutamine supplementation is standard care when parenteral nutrition is given for critical illness. There are data of a reduced mortality when glutamine supplementation is given. In addition, standard commercial products for parenteral nutrition do not contain any glutamine due to glutamine instability in aqueous solutions. For the majority of critical ill patients who are fed enterally, the available evidence is insufficient to recommend glutamine supplementation. Standard formul...

  11. Supplemental Colleges

    Department of Homeland Security — The Supplemental Colleges layer attempts to capture additional Post Secondary Education campuses of colleges and universities associated with a single campus listed...

  12. Evaluation of Rice Bran and Wheat Bran as Supplemental Feed Compared to a Commercial Feed for Monoculture of GIFT Strain of Tilapia (Oreochromis niloticus) in Bangladesh

    Hossain, Md. Sakhawat; HOSSAIN Md. Arshad; MAMUN Md. Abdullah-Al; ALI Md. Zulfikar; BULBUL Mahbuba; Koshio, Shunsuke; Kader, Md. Abdul; コシオ, シュンスケ; 越塩, 俊介

    2011-01-01

    A feeding trial was conducted to evaluate the effect of rice bran and wheat bran as supplementary feed in comparison to a commercial feed for monoculture of GIFT strain of tilapia (Oreochromis niloticus). Four experimental diets such as commercial tilapia diet, rice bran, wheat bran, and a mixture of rice bran and wheat bran (50:50) were assigned to four treatments designated as T1, T2, T3 and T4 respectively. Triplicate groups of fish (initial mean weight 2.80 g) were delivered the test diet...

  13. Spectroscopic and structural impact of a stem base-pair change in DNA hairpins: GTTC-ACA-GAAC versus GTAC-ACA-GTAC

    Lamoureux, Michèle; Patard, Louis; Hernandez, Belen; Couesnon, Thierry; Santini, Guillaume P. H.; Cognet, Jean A. H.; Gouyette, Catherine; Cordier, Christine

    2006-09-01

    Successive investigations over the last decade have revealed and confirmed a stable loop closure in a family of d-[GTAC-5Pur6N7N-GTAC] hairpins, where 5Pur6N7N is a AAA, GAG and AXC loop (X being any nucleotide). The trinucleotide loop is characterized by a well defined 5Pur-7N mispairing mode, and by upfield chemical shifts for three sugar protons of the apical nucleotide 6N. The GTTC-ACA-GAAC DNA hairpin, of interest for its likely involvement in Vibrio cholerae genome mutations, has now been investigated. The GTAC-ACA-GTAC DNA hairpin has also been studied because it is intermediate between the other structures, as it contains the loop of the hairpin under consideration and the stem of the above family. The two hairpins with the ACA loop are stable. They show the same mispairing mode and similar upfield shifts as the previous family, but GTTC-ACA-GAAC seems to be slightly less compact than any other. GTTC-ACA-GAAC is remarkable in that it exhibits a B II character for the phosphate-ester conformation at 8Gp9A, together with a swing of the upper hairpin into the major groove that, in particular, brings 6CH1' roughly as close to 7AH2 as to 6CH6. These unexpected structural features are qualitatively deduced from 1H and 31P NMR spectra, and confirmed by Raman spectroscopy. This comparative study shows that not only the loop sequence but also the stem sequence may control hairpin structures.

  14. Effect of insoluble fiber supplementation applied at different ages on digestive organ weight and digestive enzymes of layer-strain poultry.

    Yokhana, J S; Parkinson, G; Frankel, T L

    2016-03-01

    Two experiments were conducted to study effects of dietary insoluble fiber (IF) on digestive enzyme function in layer poultry. In Experiment 1, 8 wk old pullets were fed a control diet (Group C) or a diet (Group IF) supplemented with 1% IF (Arbocel RC). After 5 wk, 6 pullets per group were killed and organ samples collected. The remaining pullets in Group C were divided into two groups: half were fed the control diet (Group C) and half were given the IF diet (Group C-IF). Similarly, half the pullets in Group IF continued on the IF diet (Group IF) and half on the control diet (Group IF-C). At 10 wk, organ samples were collected. BW at wk 5 (IF, 1364.8 g; C, 1342.9 g) and 10 wk (IF, 1678.1 g; IF-C, 1630.5 g; C-IF, 1617.1 g; C, 1580.4 g) were not different. At wk 5, the relative proventricular weight (0.41 g/100 g BW) and activities of pepsin (75.3 pepsin units/g proventriculus/min) and pancreatic general proteolytic activity (GP) (122.9 μmol tyrosine produced/g tissue) were greater (P Pancreatic GP activity was greater (P enzyme activities in IF pullets may contribute to an improvement in feed utilization. PMID:26574026

  15. Supplemental Oxygen

    ... Disease Lookup > COPD > Diagnosing and Treating COPD Supplemental Oxygen Sometimes with chronic obstructive pulmonary disease (COPD), lung ... in people with severe lung disease Three Ways Oxygen Therapy Is Supplied Compressed oxygen gas and liquid ...

  16. Dietary Supplements

    ... are not intended to treat, diagnose, prevent, or cure diseases. Do not take supplements instead of your ... Partners Women's Health Topics Mammography Women and Diabetes HPV, HIV, Birth Control Heart Health for Women Pregnancy ...

  17. Nepali Supplements.

    Peace Corps, Washington, DC.

    This volume is intended as a supplement to Nepali language instruction. It contains songs, numerals, dialogues in Devanagari script, a Nepali-English, English-Nepali glossary, and an English-Nepali surveyor technical glossary. (AM)

  18. Detection and Identification of Probiotic Lactobacillus plantarum Strains by Multiplex PCR Using RAPD-Derived Primers

    Alex Galanis; Yiannis Kourkoutas; Chrysoula C. Tassou; Nikos Chorianopoulos

    2015-01-01

    Lactobacillus plantarum 2035 and Lactobacillus plantarum ACA-DC 2640 are two lactic acid bacteria (LAB) strains that have been isolated from Feta cheese. Both display significant potential for the production of novel probiotic food products. The aim of the present study was the development of an accurate and efficient method for the molecular detection and identification of the above strains in a single reaction. A multiplex PCR assay was designed for each strain, based on specific primers de...

  19. Estimating the Counterfactual: How Many Uninsured Adults Would There Be Today Without the ACA?

    Blumberg, Linda J; Garrett, Bowen; Holahan, John

    2016-01-01

    Time lags in receiving data from long-standing, large federal surveys complicate real-time estimation of the coverage effects of full Affordable Care Act (ACA) implementation. Fast-turnaround household surveys fill some of the void in data on recent changes to insurance coverage, but they lack the historical data that allow analysts to account for trends that predate the ACA, economic fluctuations, and earlier public program expansions when predicting how many people would be uninsured without comprehensive health care reform. Using data from the Current Population Survey (CPS) from 2000 to 2012 and the Health Reform Monitoring Survey (HRMS) data for 2013 and 2015, this article develops an approach to estimate the number of people who would be uninsured in the absence of the ACA and isolates the change in coverage as of March 2015 that can be attributed to the ACA. We produce counterfactual forecasts of the number of uninsured absent the ACA for 9 age-income groups and compare these estimates with 2015 estimates based on HRMS relative coverage changes applied to CPS-based population estimates. As of March 2015, we find the ACA has reduced the number of uninsured adults by 18.1 million compared with the number who would have been uninsured at that time had the law not been implemented. That decline represents a 46% reduction in the number of nonelderly adults without insurance. The approach developed here can be applied to other federal data and timely surveys to provide a range of estimates of the overall effects of reform. PMID:27076474

  20. Molecular Cloning and Expression of a New Allergen of Acacia farnesiana (Aca f 2

    Najmeh Sepahi

    2015-10-01

    Full Text Available Inhalation of pollens from different species of Acacia is a common cause of respiratory allergy in tropical areas of the world. Acacia farnesiana is commonly used as street trees in towns and ornamental shade trees in parks and gardens throughout arid and semi-arid regions of Asia. This study aimed to produce and purify the A. farnesiana pollen profilin (Aca f 2 and evaluate its nucleotide sequence homology with profilins of common allergenic plants to predict allergenic cross-reactivity.Thirty-nine patients who were allergic to Acacia pollens were included in the study. Cloning of Acacia profilin-coding sequence was performed by polymerase chain reaction using primers from Acacia pollen RNA. The cDNA of Acacia pollen profilin was then expressed in Escherichia coli using pET-21b(+ vector and purified by metal affinity chromatography. Immunoreactivity of the recombinant Acacia profilin (rAca f 2 was evaluated by specific ELISA, immunoblotting, and inhibition assays.The coding sequence of the Acacia profilin cDNA was recognized as a 399-bp open reading frame encoding 133 amino acid residues. Eighteen patients (18/39, 46.15% had significant specific IgE levels against Aca f 2. Immunodetection and inhibition assays indicated that purified Aca f 2 might be the same as that in the crude extract.Aca f2, the first allergen from A. farnesiana pollen, was identified as belonging to the family ofprofilins. The amino acid sequence homology analysis showed high cross-reactivity betweenAca f 2 and other profilins from botanically unrelated common allergenic plants.

  1. Molecular Cloning and Expression of a New Allergen of Acacia farnesiana (Aca f 2).

    Sepahi, Najmeh; Khodadadi, Ali; Assarehzadegan, Mohammad-Ali; Amini, Akram; Zarinhadideh, Farnoosh; Ali-Sadeghi, Hosein

    2015-08-01

    Inhalation of pollens from different species of Acacia is a common cause of respiratory allergy in tropical areas of the world. Acacia farnesiana is commonly used as street trees in towns and ornamental shade trees in parks and gardens throughout arid and semi-arid regions of Asia. This study aimed to produce and purify the A. farnesiana pollen profilin (Aca f 2) and evaluate its nucleotide sequence homology with profilins of common allergenic plants to predict allergenic cross-reactivity. Thirty-nine patients who were allergic to Acacia pollens were included in the study. Cloning of Acacia profilin-coding sequence was performed by polymerase chain reaction using primers from Acacia pollen RNA. The cDNA of Acacia pollen profilin was then expressed in Escherichia coli using pET-21b(+) vector and purified by metal affinity chromatography. Immunoreactivity of the recombinant Acacia profilin (rAca f 2) was evaluated by specific ELISA, immunoblotting, and inhibition assays. The coding sequence of the Acacia profilin cDNA was recognized as a 399-bp open reading frame encoding 133 amino acid residues. Eighteen patients (18/39, 46.15%) had significant specific IgE levels against Aca f 2. Immunodetection and inhibition assays indicated that purified Aca f 2 might be the same as that in the crude extract. Aca f2, the first allergen from A. farnesiana pollen, was identified as belonging to the family of profilins. The amino acid sequence homology analysis showed high cross-reactivity between Aca f 2 and other profilins from botanically unrelated common allergenic plants. PMID:26547704

  2. Os efeitos da trimetazidina na variabilidade da frequência cardíaca (VFC) em pacientes com insuficiência cardíaca Los efectos de la trimetazidina en la variabilidad de la frecuencia cardíaca (VFC) en pacientes con insuficiencia cardíaca The effects of trimetazidine on heart rate variability in patients with heart failure

    Yilmaz Gunes; Unal Guntekin; Mustafa Tuncer; Musa Sahin

    2009-01-01

    FUNDAMENTO: Tem sido demonstrado que diminuições na variabilidade da frequência cardíaca (VFC) estão relacionadas com o prognóstico na insuficiência cardíaca (IC). A administração crônica de trimetazidina, além da terapia convencional, tem melhorado a classe funcional e a função ventricular esquerda de pacientes com IC. OBJETIVO: Avaliar os efeitos da trimetazidina na VFC em pacientes com IC de origem isquêmica, recebendo tratamento otimizado. MÉTODOS: Trimetazidina 20 mg 3 vezes/dia foi adic...

  3. Registro Nacional de Internación por Insuficiencia Cardíaca

    Raúl Borracci; Fernando Botto; María Marturano; Susana Fernández; Javier Guetta; Patricia Blanco; Leandro Rodríguez; Enrique Fairman; Jorge Thierer; Consejo de Emergencias Cardiovasculares. Área de Investigación. Sociedad Argentina de Cardiología

    2009-01-01

    IntroducciónLa insuficiencia cardíaca representa una de las principales causas de internación con una tasa elevada de complicaciones y cuyo enfoque no parece que haya mejorado en los últimos años.ObjetivosConocer el perfil epidemiológico y clínico, analizar las medidas terapéuticas y la evolución durante la internación y a los 3 meses de pacientes admitidos por insuficiencia cardíaca descompensada.Material y métodosRegistro prospectivo, multicéntrico de pacientes internados por insuficiencia ...

  4. Toward a conceptual understanding of acute cultural adaptation: A preliminary examination of ACA in female swimming

    Ryba, Tatiana; Haapanen, Saara; Mosek, Shwiko; Ng, Kwok

    2012-01-01

    This paper considers a novel approach to researching adaptation in transnational athletes. The first part introduces a conceptualisation of acute cultural adaptation (ACA), which extends the current literature in sport psychology by offering original insights into mechanisms underpinning adaptive...... psychological needs. The second part of the paper engages the conceptualisation of ACA to make sense of the adaptive processes as experienced by female swimmers from Finland during their training camp in Australia. The study’s findings highlight relatedness as a discursive cultural space, offering a starting...... point for examining the role of culture in psychological functions during short-term relocation....

  5. Ethical Challenges in a Complex World: Highlights of the 2005 ACA Code of Ethics

    Kocet, Michael M.

    2006-01-01

    Being an effective counselor includes having knowledge of and the ability to integrate a code of ethics into one's professional practice. This article addresses some of the highlights of the changes in the 2005 ACA [American Counseling Association] Code of Ethics such as end-of-life issues, boundaries and relationships, and multicultural and…

  6. Perils ahead: employers cheer mandate's delay, but move leaves ACA open to new attacks.

    Block, Jonathan; Daly, Rich

    2013-07-01

    When the Obama administration announced it was delaying enforcement of the employer mandate in the ACA for one year, employer groups celebrated. But others had some troubling questions. "One has to hope, however, that the administration has thought through the ramifications of this delay for the other provisions," says Tim Jost, left, a law professor at Washington & Lee University. PMID:23878915

  7. Glutamine supplementation.

    Wernerman, Jan

    2011-01-01

    Intravenous glutamine supplementation is standard care when parenteral nutrition is given for critical illness. There are data of a reduced mortality when glutamine supplementation is given. In addition, standard commercial products for parenteral nutrition do not contain any glutamine due to glutamine instability in aqueous solutions. For the majority of critical ill patients who are fed enterally, the available evidence is insufficient to recommend glutamine supplementation. Standard formulation of enteral nutrition contains some glutamine: 2-4 g/L. However, this dose is insufficient to normalize glutamine plasma concentration.Plasma concentration of glutamine is low in many patients with critical illness and a low level is an independent risk factor for mortality. A low plasma glutamine concentration is the best indicator of glutamine depletion. Data are emerging about how the endogenous production of glutamine is regulated. We know that skeletal muscle is the major producer of glutamine and that a part of the profound depletion of skeletal muscle seen in critical illness is a reflection of the need to produce glutamine.Glutamine is utilized in rapidly dividing cells in the splanchnic area. Quantitatively most glutamine is oxidized, but the availability of glutamine in surplus is important for the de novo synthesis of nucleotides and necessary for cell division and protein synthesis. More knowledge about the regulation of the endogenous production of glutamine is needed to outline better guidelines for glutamine supplementation in the future. PMID:21906372

  8. Značajke prostorne distribucije sušaca u bukovo-jelovoj šumi

    Pernar, Renata; Seletković, Ante; Ančić, Mario; Sučić, Jelena

    2011-01-01

    Utvrđivanje prostornoga rasporeda oštećenih stabala i sušaca te njihovo praćenje jedan je od prioriteta potrajnoga gospodarenja. Inventarizacija sušaca interpretacijom infracrvenih kolornih (ICK) aerosnimaka i GIS-a omogućuje učinkovito prebrojavanje (detekciju) i prostornu distribuciju (kartiranje) sušaca. Interpretacijom ICK aerosnimaka može se ustanoviti trenutačno stanje, tj. u kratkom razdoblju dobiti objektivan uvid u stanje šuma (baza podataka), a kartiranjem na digitalnom ortofotu (DO...

  9. The ACA training programme to improve communication between general practitioners and their palliative care patients: development and applicability

    Slort Willemjan

    2012-06-01

    Full Text Available Abstract We describe the development of a new training programme on GP-patient communication in palliative care, and the applicability to GPs and GP Trainees. This ‘ACA training programme’ focuses on  A vailability of the GP for the patient,  C urrent issues that should be raised by the GP, and  A nticipating various scenarios. Evaluation results indicate the ACA training programme to be applicable to GPs and GP Trainees. The ACA checklist was appreciated by GPs as useful both in practice and as a learning tool, whereas GP Trainees mainly appreciated the list for use in practice.

  10. 犬钩虫C型凝集素AcaCTL-1基因的克隆及表达%Cloning and expression of a C-type lectin(AcaCTL-1)gene from Ancylostoma caninum

    邓莉; 金娴; 何庆丰; 许琴英; 吴亚敏; 彭礼飞

    2010-01-01

    目的 分离鉴定犬钩虫C型凝集素AcaCTL-1基因,并在大肠埃希菌中表达.方法 根据EST序列设计引物,用RT-PCR及3,(RACE技术扩增获得AcaCTL-1伞长cDNA序列,并对其进行初步生物信息学分析;将AcaCTL-l成熟肽编码序列克隆、连接到表达载体pET32a.构建重组质粒pET32a/AcaCTL-1;在大肠埃希菌BL21(DE3)中诱导表达重组蛋白,SDS-PAGE分析表达情况,Ni亲和层析纯化可溶性蛋白.结果 成功克隆了AcaCTL-1全长cDNA序列,其最大开放阅读框由525 bp组成,预测编码174个氨基酸残基组成的蛋白,含17个氨基酸组成的信号肽,为C型凝集索家族蛋白成员;构建pET32a/AcaCTL-1莺组质粒,并在大肠埃希菌中高效表达.表达产物多以包涵体形式存在,小部分为可溶性蛋白.结论 成功克隆并表达了犬钩虫C型凝集素AcaCTL-基因,为进一步了解AcaCTL-1的功能奠定了基础.

  11. Despite Resources From The ACA, Most States Do Little To Help Addiction Treatment Programs Implement Health Care Reform

    Andrews, Christina; Abraham, Amanda; Grogan, Colleen M.; Pollock, Harold A.; Bersamira, Clifford; Humphreys, Keith; Friedmann, Peter

    2015-01-01

    The Affordable Care Act (ACA) dramatically expands health insurance for addiction treatment and provides unprecedented opportunities for service growth and delivery model reform. Yet most addiction treatment programs lack the staffing and technological capabilities to respond successfully to ACA-driven system change. In light of these challenges, we conducted a national survey to examine how Single State Agencies for addiction treatment—the state governmental organizations charged with overse...

  12. Nutritional supplements

    Petersen, Gry Bjerg; Andersen, Jens Rikardt

    2015-01-01

    Background: Several studies have indicated that cancer patients have significantly altered taste sensitivity without specifying the preferences. One of the related problems is low compliance to nutritional therapy with oral nutritional supplements (ONS) in patients suffering severe weight loss....... Objective: We wanted to investigate taste preferences and sensoric characteristics among three usually used ONS in patients with malignant haematological disease during cytotoxic treatment. Design: Tested drinks were: Protin® (protein-enriched-milk, ARLA), Nutridrink® (NUTRICIA) and hospital-produced drink...

  13. Study on the correlationship among serum ACA, hs-CRP and Hcy levels in patients with cerebral infarction

    Objective: To study the changes of and correlationship among serum anti-cardiolipin antibody (ACA), hs-CRP and Hcy levels in patients with cerebral infarction. Methods: Serum ACA (with ELISA), hs-CRP(with RIA) and Hcy(with CLIA) levels were measured in 210 patients with cerebral infarction and 30 controls. Results: The serum ACA, hs-CRP and Hcy contents in the patients with cerebral infarction were significantly higher than those in the controls. Serum hs-CRP and Hcy levels in the patients were mutually positively correlated (r=0.714). Serum ACA levels in the patients were also positively correlated with serum hs-CRP levels(r=0.893) and Hcy levels(r=0.597). Conclusion: High serum ACA, hs-CRP and Hcy levels were independent risk factors in the development of cerebral infarction. Combined determination of serum ACA, hs-CRP and Hcy levels was helpful for early diagnosis in patients with cerebral infarction. (authors)

  14. The cytotoxic effects a of ACA1 on human melanoma cell line

    R. Yaraie; M.R. Jalali Nadoushan; Naseri, M.; S. Shahrokhi; T. Ghazanfari; Kardar, M.

    2006-01-01

    Background and purpose: Different methods such as surgery, chemotherapy, radiotherapy, hormone therapy and immunotherapy are used for treatment of melanoma cancer. Unfortunately they don't always have desirable results and they may have unfavorable side effects. Researchers try to find new, more effective drugs with low side effects. In this study we evaluated the cytotoxic effect of ACA-1, a water extract of a traditional Iranian medicinal herbs on a melanoma cell line SKMEL-3.Materials and ...

  15. Disorders of Accommodative Convergation and Accommodation (AC/A) Relations at Traumatic Brain Injury

    Serdarevic, Raif

    2015-01-01

    Introduction: Accommodative Convergence/Accommodation (AC/A) ratio is constant at one and the same person in the course of life, i.e. the same ratio accommodative convergence monitor any change in accommodation measured in diopters. Such a perfect relationship is possible if there are no refractive anomalies in both eyes and oculomotor imbalance of eye muscles. Material and methods: We are examined 50 patients with close brain injury, and patients which had problems with near vision, accommod...

  16. Triagem sorológica para doença celíaca em adolescentes

    Maria Ester Pereira da Conceição-Machado

    2015-03-01

    Full Text Available OBJETIVO: Este estudo objetivou identificar a soroprevalência da doença celíaca em adolescentes de escolas públicas da cidade de Salvador, Bahia. MÉTODO: Trata-se de um estudo transversal com amostra probabilística de 1.213 adolescentes de 11 a 17 anos, de ambos os sexos. O índice de massa corporal foi utilizado para o diagnóstico do estado nutricional, adotando-se os percentis segundo idade e sexo, propostos pela World Health Organization. O anticorpo anti-transglutaminase humana da classe imunoglobulina A (anti-tTG-IgA foi adotado como teste sorológico para triagem da doença celíaca e foi determinado pela técnica do ensaio imunoabsorvente ligado à enzima (ELISA. Foi realizada análise descritiva, utilizando-se a proporção e a média (desvio padrão. RESULTADOS: O sexo feminino predominou entre os adolescentes, e a maioria encontrava-se com adequado estado nutricional. O anticorpo anti-tTG-IgA foi positivo em 6/1.213 (0,49% adolescentes. CONCLUSÃO: A soroprevalência de doença celíaca entre os adolescentes estudados foi 0,49%. Novas investigações são necessárias para confirmar a prevalência de doença celíaca nessa faixa etária.

  17. Novi nalazi recentnih ramenonožaca (Brachiopoda) u istočnom dijelu sjevernog Jadrana

    Legac, Mirjana

    2012-01-01

    Navode se podaci za četiri vrste ramenonožaca nađenih na tri nova nalazišta: u uzorku sedimenta iz morske špilje Medova buža s jednog metra dubine (Novocrania turbinata, Argyrotheca cuneata i Joania cordata), s obraštaja fragmenta amfore u Velom kolu na dubini od 25 m (Argyrotheca cuneata i Megathiris detruncata) otok Rab i u Unijskom kanalu s dubine od 52 m (Joania cordata).

  18. Molecular Cloning and Expression of a New Allergen of Acacia farnesiana (Aca f 2)

    Najmeh Sepahi; Ali Khodadadi; MohammadAli Assarehzadegan; Akram Amini; Farnoosh Zarinhadideh; Hosein Ali-Sadeghi

    2015-01-01

    Inhalation of pollens from different species of Acacia is a common cause of respiratory allergy in tropical areas of the world. Acacia farnesiana is commonly used as street trees in towns and ornamental shade trees in parks and gardens throughout arid and semi-arid regions of Asia. This study aimed to produce and purify the A. farnesiana pollen profilin (Aca f 2) and evaluate its nucleotide sequence homology with profilins of common allergenic plants to predict allergenic cross-reactivity.Thi...

  19. Complicações cardíacas em cirurgia vascular

    Karla Scamardi Martins Pereira

    2016-01-01

    Full Text Available Resumo Contexto Aproximadamente 60% dos pacientes portadores de doença arterial oclusiva crônica periférica têm doença coronariana grave, sendo que a principal causa de morte no pós-operatório de cirurgia vascular de grande porte é o infarto agudo do miocárdio. Objetivos Determinar a prevalência da doença coronariana em pacientes submetidos a cirurgia vascular eletiva de grande porte e sua relação com as complicações cardiológicas pós-operatórias. Métodos Foram analisados 200 pacientes submetidos a cirurgia vascular arterial eletiva: doença obstrutiva carotídea, aortoilíaca e femoropoplítea distal e doença aneurismática de aorta abdominal e de artérias ilíacas. Os pacientes constituíram três grupos: grupo I, sem doença coronariana; grupo II, com doença coronariana assintomática; e grupo III, com doença coronariana sintomática. As complicações cardiológicas consideradas foram infarto agudo do miocárdio fatal e não fatal, insuficiência cardíaca congestiva, choque cardiogênico, fibrilação atrial aguda e outras arritmias. Resultados Complicações cardíacas ocorreram em 11 pacientes (5,5%: três infartos agudos do miocárdio não fatais (1,5% sempre em pacientes do grupo III. A complicação cardíaca mais frequente foi arritmia (exceto fibrilação atrial ocorrida em cinco (2,5% pacientes, sendo três do grupo II. A mortalidade precoce foi de nove pacientes (4,5%. Apenas uma morte foi decorrente de problema cardíaco: choque cardiogênico em paciente do grupo III. Conclusões A doença coronariana não foi preditora de óbito nos pacientes submetidos a cirurgia vascular periférica de grande porte. A sobrevida dos pacientes com ou sem doença coronariana não mostrou diferenças estatísticas.

  20. Diabetes and Dietary Supplements

    ... R S T U V W X Y Z Diabetes and Dietary Supplements: In Depth Share: On This ... health product or practice. Are dietary supplements for diabetes safe? Some dietary supplements may have side effects, ...

  1. Annual Statistical Supplement, 2015

    Social Security Administration — The Annual Statistical Supplement, 2015 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  2. Annual Statistical Supplement, 2011

    Social Security Administration — The Annual Statistical Supplement, 2011 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  3. Annual Statistical Supplement, 2003

    Social Security Administration — The Annual Statistical Supplement, 2003 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  4. Annual Statistical Supplement, 2004

    Social Security Administration — The Annual Statistical Supplement, 2004 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  5. Annual Statistical Supplement, 2008

    Social Security Administration — The Annual Statistical Supplement, 2008 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  6. Annual Statistical Supplement, 2002

    Social Security Administration — The Annual Statistical Supplement, 2002 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  7. Annual Statistical Supplement, 2001

    Social Security Administration — The Annual Statistical Supplement, 2001 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  8. Annual Statistical Supplement, 2006

    Social Security Administration — The Annual Statistical Supplement, 2006 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  9. Annual Statistical Supplement, 2000

    Social Security Administration — The Annual Statistical Supplement, 2000 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  10. Annual Statistical Supplement, 2009

    Social Security Administration — The Annual Statistical Supplement, 2009 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  11. Annual Statistical Supplement, 2010

    Social Security Administration — The Annual Statistical Supplement, 2010 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  12. Annual Statistical Supplement, 2007

    Social Security Administration — The Annual Statistical Supplement, 2007 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  13. Annual Statistical Supplement, 2014

    Social Security Administration — The Annual Statistical Supplement, 2014 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  14. Annual Statistical Supplement, 2005

    Social Security Administration — The Annual Statistical Supplement, 2005 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  15. Perspectivas futuras de tratamiento en la insuficiencia cardíaca: del trasplante de células a la regeneración cardíaca

    Prosper, F.; Herreros, J.; J. Barba

    2004-01-01

    En los últimos años hemos asistido a un interés creciente por el tratamiento de la insuficiencia cardíaca mediante el trasplante de células madre. Mientras que los estudios con células madre de músculo (mioblastos) se iniciaron hace más de 10 años, la posibilidad de que las células madre de la médula ósea tengan un enorme potencial de diferenciación y proliferación ha estimulado la investigación con otros tipos de células madre. Estos estudios experimentales han demost...

  16. Effects of Transgenic Tobacco Plants Expressing ACA Gene from Amaranthus caudatus on the Population Development of Myzus persicae

    GUOHong-Nian; JIAYan-Tao; ZHOUYong-Gang; ZHANGZhen-Shan; OUYANGQing; JIANGYing; TIANYing-Chuan

    2004-01-01

    To investigate the possible function of the agglutinin from Amaranthus caudatus L. (ACA) in plant defending against insect pests, ACA cDNA was cloned by RT-PCR and the 5' and 3' sequences were confirmed by rapid amplification of cDNA ends (RACE). The phloem-specific expression vector of ACA gene, pBCACAc, was constructed based on the plant binary vector pBC438 and transfered into tobacco plants via Agrobacterium-mediated transformation method. Results from PCR and Southern blotting analysis showed that AOA gene was integrated into the genomes of transformed plants and the transgene integration varied from one to four estimated copies per genome. Western blotting analysis indicated that ACA gene was transcribed and translated in the transgenic plants. The bioassay of Myzus persicae Sulzer on detached leaves demonstrated that the 78% transgenic tobacco plants displayed an average aphid-resistant rate of more than 75%. Some apterous progeny of M. persicae were found dead on the resistant plants. These results indicate that ACA gene should be an effective aphid-resistant gene and could be valuable for application in crop breeding for aphid resistance.

  17. Clinical significance of measurement serum Hcy, ACA and APN levels after treatment in patients with acute cerebral infarction

    Objective: To explore the clinical significance of changes of serum Hcy, ACA and APN levels after treatment in patients with acute cerebral infarction. Methods: Serum Hcy (with RIA), serum ACA, APN (with ELISA) levels were determined in 32 patients with acute cerebral infarction both before and after treatment as well as in 35 normal controls. Result: Before treatment the serum Hcy, ACA levels were significantly higher than those in controls (P<0.01), while the serum APN levels were significantly lower than those in controls (P<0.01), after treatment for 3 months, the levels remained still different from those in controls (P<0.05). Serum Hcy levels were positively correlated with serum ACA levels (r=0.6138, P<0.01), while the serum Hcy levels were negatively correlated with serum APN levels (r=-0.4218, P<0.05). Conclusion: serum Hcy, ACA and APN levels were closely related to the diseases process of acute cerebral infarction and determination of which were of great clinical importance. (authors)

  18. Cloning, expression and anticoagulant activities of anticoagulant peptide AcaNAP8 from Ancylostoma caninum%犬钩虫抗凝肽AcaNAP8的原核表达及其抗凝活性

    殷环; 邓莉; 王会兰; 吴亚敏; 彭礼飞

    2010-01-01

    目的 在大肠杆菌中重组表达犬钩虫抗凝肽AcaNAP8基因,并检测表达产物抗凝活性.方法 设计引物,将AcaNAP8成熟肽编码序列克隆、连接到原核表达载体pET32a,构建重组表达质粒;成功构建的重组表达质粒转化到大肠杆菌BL21(DE3)中用IPTG诱导表达,SDS-PAGE分析表达情况;诱导表达的重组蛋白用Ni亲和层析进行纯化;用凝血酶原时问(PT)和活化的部分凝血活酶时间(aPTTr)检测重组产物体外抗凝活性.结果 成功构建了pET32a/AcaNAP8原核表达重组质粒,在大肠杆菌中成功表达并获得了重组AcaNAP8,表达产物能明显延长PT及aPTT.结论 在大肠杆菌中成功表达了AcaNAP8融合蛋白,表达产物具有显著抗凝活性.该实验为进一步探讨AcaNAP8的作用机制及应用奠定了基础.

  19. Prevalencia de hiperparatiroidismo secundario en pacientes con insuficiencia cardíaca estable

    Donaire Sansó, Gemma

    2016-01-01

    OBJETIVOS: El objetivo principal fue determinar la prevalencia de hiperparatiroidismo secundario (sHPT) y de déficit de vitamina D (DVD) en pacientes con insuficiencia cardíaca (IC) estable. Otros objetivos fueron: analizar la relación entre sHPT/DVD y los tratamientos de la IC, evaluar su relación con datos ecocardiográficos, clínicos y analíticos, la relación con otros biomarcadores y con la morbimortalidad, así como determinar los pacientes candidatos a realizar tratamiento del sHPT. ...

  20. Programa paciente experto en insuficiencia cardíaca en Navarra

    Iriarte Brasil, Nathalie

    2014-01-01

    La insuficiencia cardíaca supone una enfermedad con una alta repercusión en el sistema sanitario y en la calidad de vida de los pacientes. Actualmente se han desarrollado diversas iniciativas para abordar este problema, en las cuales se fomenta el autocuidado del paciente. Por esta razón se ha planteado como objetivo elaborar de forma teórica un programa de este tipo. Para este proceso se ha realizado una adaptación de la metodología de la Universidad de Standford. La principal característica...

  1. Caquexia associada à insuficiência cardíaca Heart failure-induced cachexia

    Marina Politi Okoshi; Fernando G. Romeiro; Paiva, Sergio A.R.; Katashi Okoshi

    2013-01-01

    Pacientes com insuficiência cardíaca frequentemente desenvolvem estado de caquexia, que constitui fator independente de redução da sobrevida. Caquexia pode ser diagnosticada quando ocorre perda de peso corporal maior que 6% do peso habitual, na ausência de outras doenças. Embora sua fisiopatologia não esteja completamente esclarecida, vários fatores parecem estar envolvidos, como diminuição da ingestão alimentar, anormalidades do trato gastrointestinal, ativação imunológica e neuro-hormonal e...

  2. Registro Nacional de Internación por Insuficiencia Cardíaca

    Raúl Borracci

    2009-01-01

    Full Text Available IntroducciónLa insuficiencia cardíaca representa una de las principales causas de internación con una tasa elevada de complicaciones y cuyo enfoque no parece que haya mejorado en los últimos años.ObjetivosConocer el perfil epidemiológico y clínico, analizar las medidas terapéuticas y la evolución durante la internación y a los 3 meses de pacientes admitidos por insuficiencia cardíaca descompensada.Material y métodosRegistro prospectivo, multicéntrico de pacientes internados por insuficiencia cardíaca descompensada en 31 centros de todo el país que aceptaron la invitación a participar del registro. Se analizaron variables vinculadas con la presentación y la evolución hospitalaria y a los 90 días.ResultadosSe incluyeron 736 pacientes, mediana de edad 74 años (64-82, 41% mujeres, 75% hipertensos, 27% diabéticos, 20% infarto previo, 30% fibrilación auricular crónica, 17% insuficiencia renal crónica, 18% EPOC. Sólo el 29% era de etiología isquémico-necrótica. El 47% había tenido internación en el último año por insuficiencia cardíaca. Las causas de descompensación más frecuentes fueron infecciones, suspensión del tratamiento y transgresión alimentaria.Las formas graves de presentación (shock cardiogénico, edema agudo de pulmón, anasarca representaron el 30%. El 60% de los pacientes se internaron en área crítica. La mediana de permanencia fue de 7 (5-11 días. La mortalidad hospitalaria fue del 8%. A los 90 días, la reinternación fue del 24,5% y la mortalidad posalta fue del 12,8%.ConclusionesEl presente registro confirma que se trata de una población de edad avanzada con una incidencia alta de comorbilidades. Muchas descompensaciones ocurren por factores prevenibles. La tasa de complicaciones es elevada y no se redujo en la última década.REV ARGENT CARDIOL 2009;77:33-39.

  3. Doença celíaca é super-representada em pacientes com constipação

    Rolf A. A. Pelleboer

    2012-04-01

    Full Text Available OBJETIVO: Tem sido sugerido que pacientes com constipação sejam triados para doença celíaca. Da mesma forma, recomenda-se a investigação desses pacientes para hipotiroidismo e hipercalcemia. Contudo, nenhuma evidência para essas recomendações está disponível até o momento. Assim, propusemos-nos determinar a prevalência de doença celíaca, hipotiroidismo e hipercalcemia em crianças com constipação. MÉTODOS: Estudo de coorte prospectivo com 370 pacientes consecutivos que preencheram os critérios de Roma III para constipação. Esses pacientes foram encaminhados por um clínico geral a um pediatra devido ao fracasso no tratamento com laxantes. RESULTADOS: A biópsia comprovou doença celíaca em sete desses pacientes. Isso é significativamente mais alto (p < 0,001 do que a prevalência de 1:198 de doença celíaca nos Países Baixos. Dois pacientes tinham tiroidite autoimune. Nenhum paciente tinha hipercalcemia. CONCLUSÕES: Conclui-se que a doença celíaca é significativamente super-representada em pacientes com constipação encaminhados por um clínico geral a um pediatra devido ao fracasso no tratamento com laxantes. Todos esses pacientes devem, portanto, ser triados para doença celíaca.

  4. Structure and Functional Studies of the CS Domain of the Essential H/ACA Ribonucleoparticle Assembly Protein SHQ1

    Singh, Mahavir; Gonzales, Fernando A.; Cascio, Duilio; Heckmann, Nathanael; Chanfreau, Guillaume; Feigon, Juli; (UCLA)

    2009-03-16

    H/ACA ribonucleoprotein particles are essential for ribosomal RNA and telomerase RNA processing and metabolism. Shq1p has been identified as an essential eukaryotic H/ACA small nucleolar (sno) ribonucleoparticle (snoRNP) biogenesis and assembly factor. Shq1p is postulated to be involved in the early biogenesis steps of H/ACA snoRNP complexes, and Shq1p depletion leads to a specific decrease in H/ACA small nucleolar RNA levels and to defects in ribosomal RNA processing. Shq1p contains two predicted domains as follows: an N-terminal CS (named after CHORD-containing proteins and SGT1) or HSP20-like domain, and a C-terminal region of high sequence homology called the Shq1 domain. Here we report the crystal structure and functional studies of the Saccharomyces cerevisiae Shq1p CS domain. The structure consists of a compact anti-parallel {beta}-sandwich fold that is composed of two {beta}-sheets containing four and three {beta}-strands, respectively, and a short {alpha}-helix. Deletion studies showed that the CS domain is required for the essential functions of Shq1p. Point mutations in residues Phe-6, Gln-10, and Lys-80 destabilize Shq1p in vivo and induce a temperature-sensitive phenotype with depletion of H/ACA small nucleolar RNAs and defects in rRNA processing. Although CS domains are frequently found in co-chaperones of the Hsp90 molecular chaperone, no interaction was detected between the Shq1p CS domain and yeast Hsp90 in vitro. These results show that the CS domain is essential for Shq1p function in H/ACA snoRNP biogenesis in vivo, possibly in an Hsp90-independent manner.

  5. Muerte súbita cardíaca en comunidades de arroyo naranjo en el periodo 2000-2010

    Ochoa Montes, Luis Alberto

    2013-01-01

    Introducción: La Muerte súbita cardíaca dada su elevada incidencia y el dramatismo en su presentación representa un importante desafío en el siglo XXI. Objetivo: Describir la presentación de la muerte súbita cardíaca en las comunidades de Arroyo Naranjo durante el período 2000-2010. Método: Estudio observacional, descriptivo y transversal. Resultados: Se registraron 10014 muertes naturales, de las cuales 1000 (10,0%) fueron súbitas. Las mayores tasas se evidenciaron en mujeres negras...

  6. INSUFICIENCIA CARDÍACA CONGESTIVA O COR PULMONALE Congestive heart failure or Cor Pulmonale

    Oscar Ernesto Amarís Peña

    2006-06-01

    Full Text Available La insuficiencia cardíaca es una de las principales causas de muerte cardiovascular y se presenta como consecuencia, en más del 70 por ciento de los casos, de las dos enfermedades cardiovasculares de mayor prevalencia: la hipertensión arterial y la enfermedad coronaria. La disnea y el edema en los miembros inferiores son los dos criterios más usados para el diagnóstico de insuficiencia cardíaca congestiva y estos son, justamente, las principales manifestaciones de los pacientes con Cor Pulmonale. Este documento propone algunos criterios para el diagnóstico diferencial de las dos entidades.Heart failure is one of the most important causes of cardiovascular death, as consequence of arterial hypertension or coronary heart disease. Dyspnea and legs edema are the commonest symptoms of congestive heart failure, but there are important symptoms in Cor Pulmonale, too. This paper propose some distinctive clues to differential diagnosis.

  7. Shifting the open enrollment period for ACA Marketplaces could increase enrollment and improve plan choices.

    Swartz, Katherine; Graves, John A

    2014-07-01

    The next open enrollment period for plans offered in the Affordable Care Act's (ACA's) insurance Marketplaces is set to occur between November 15, 2014, and February 15, 2015--just when many lower-income people are financially stressed by demands of the holiday season. Recent research by experimental psychologists and behavioral economists strongly suggests that when people's decision-making capacity (bandwidth) is stretched thin, either they cannot make decisions or they make poor choices. Using data from nearly a decade of US-based Internet search queries to measure population behavior, we found considerable seasonality in measures of financial stress and in when people seek out information on health insurance plans. A more opportune time for scheduling open enrollment for the ACA Marketplaces may be between February 15 and April 15--weeks when low-income people typically receive income tax refunds and Earned Income Tax Credit payments. Such lump-sum payments could be applied to pay individuals' share of premiums. PMID:24966287

  8. Accurate placement of substrate RNA by Gar1 in H/ACA RNA-guided pseudouridylation.

    Wang, Peng; Yang, Lijiang; Gao, Yi Qin; Zhao, Xin Sheng

    2015-09-01

    H/ACA RNA-guided ribonucleoprotein particle (RNP), the most complicated RNA pseudouridylase so far known, uses H/ACA guide RNA for substrate capture and four proteins (Cbf5, Nop10, L7Ae and Gar1) for pseudouridylation. Although it was shown that Gar1 not only facilitates the product release, but also enhances the catalytic activity, the chemical role that Gar1 plays in this complicated machinery is largely unknown. Kinetics measurement on Pyrococcus furiosus RNPs at different temperatures making use of fluorescence anisotropy showed that Gar1 reduces the catalytic barrier through affecting the activation entropy instead of enthalpy. Site-directed mutagenesis combined with molecular dynamics simulations demonstrated that V149 in the thumb loop of Cbf5 is critical in placing the target uridine to the right position toward catalytic D85 of Cbf5. The enzyme elegantly aligns the position of uridine in the catalytic site with the help of Gar1. In addition, conversion of uridine to pseudouridine results in a rigid syn configuration of the target nucleotide in the active site and causes Gar1 to pull out the thumb. Both factors guarantee the efficient release of the product. PMID:26206671

  9. Tratamento otimizado e redução da frequência cardíaca na insuficiência cardíaca crônica

    Irineu Blanco Moreno

    2013-11-01

    Full Text Available FUNDAMENTO: A Insuficiência Cardíaca (IC é uma síndrome que cursa com má evolução nas formas avançadas. O bloqueio neuro-hormonal modifica essa história natural; no entanto, ele com frequência é subotimizado. OBJETIVO: Neste estudo procuramos verificar em qual percentual médicos cardiologistas habituados no tratamento da IC conseguem prescrever as doses-alvo dos medicamentos de comprovada eficácia. MÉTODOS: Foram selecionados consecutivamente 104 pacientes ambulatoriais com disfunção sistólica, todos sob tratamento estabilizado. Avaliaram-se dados demográficos e o tratamento verificando-se as doses atingidas. Os achados são apresentados em percentual e fizeram-se correlações entre as diferentes variáveis. RESULTADOS: A idade média dos pac. foi de 64,1 ± 14,2 anos, com PAS 115,4 ± 15,3 mmHg, FC de 67,8 ± 9,4 bpm, peso 76,0 ± 17,0 kg e em ritmo sinusal (90,4%. Quanto ao tratamento, 93,3% estavam recebendo um bloqueador do SRA (52,9% IECA, todos recebiam betabloqueador (BB, sendo o carvedilol o mais prescrito (92,3%. Quanto às doses: 97,1% dos que recebiam um BRA estavam com dose abaixo da ideal; os que recebiam IECA 52,7% receberam dose otimizada. Quanto ao BB, em 76,0% foi possível prescrever as doses alvos. Nesse grupo de pac. a maioria com dose alvo do BB, pode-se observar que 36,5% apresentavam frequência cardíaca igual ou maior que 70 bpm em ritmo sinusal. CONCLUSÕES: Médicos cardiologistas habituados no tratamento da IC conseguem prescrever as doses-alvo de inibidores da ECA e BB para a maioria dos pac. Mesmo recebendo as doses preconizadas, cerca de um terço dos pac. persiste com FC acima de 70 bpm e deveria ter seu tratamento otimizado.

  10. Cellular response to substrate rigidity is governed by either stress or strain.

    Yip, Ai Kia; Iwasaki, Katsuhiko; Ursekar, Chaitanya; Machiyama, Hiroaki; Saxena, Mayur; Chen, Huiling; Harada, Ichiro; Chiam, Keng-Hwee; Sawada, Yasuhiro

    2013-01-01

    Cells sense the rigidity of their substrate; however, little is known about the physical variables that determine their response to this rigidity. Here, we report traction stress measurements carried out using fibroblasts on polyacrylamide gels with Young's moduli ranging from 6 to 110 kPa. We prepared the substrates by employing a modified method that involves N-acryloyl-6-aminocaproic acid (ACA). ACA allows for covalent binding between proteins and elastomers and thus introduces a more stable immobilization of collagen onto the substrate when compared to the conventional method of using sulfo-succinimidyl-6-(4-azido-2-nitrophenyl-amino) hexanoate (sulfo-SANPAH). Cells remove extracellular matrix proteins off the surface of gels coated using sulfo-SANPAH, which corresponds to lower values of traction stress and substrate deformation compared to gels coated using ACA. On soft ACA gels (Young's modulus 20 kPa), traction stress plateaus at a limiting value and the substrate deformation decreases with increasing substrate rigidity. Sustained substrate strain on soft substrates and sustained traction stress on stiff substrates suggest these may be factors governing cellular responses to substrate rigidity. PMID:23332055

  11. Influência da vitamina C na modulação autonômica cardíaca no repouso e durante o exercício isométrico em crianças obesas The influence of vitamin C on cardiac autonomic modulation at rest and during isometric exercise in obese children

    Fabio Alexandre dos Santos Lira

    2012-09-01

    Full Text Available OBJETIVOS: comparar, entre obesos e eutróficos, os parâmetros de modulação autonômica cardíaca e analisar o efeito da suplementação da vitamina C na modulação autonômica cardíaca em crianças obesas, no repouso e durante o exercício isométrico respectivamente. MÉTODOS: participaram oito crianças eutróficas (IMC = 18 ± 1Kg/cm² e 21 obesas (IMC = 29 ± 1Kg/cm², com idade entre 8 e 11 anos, ambos os gêneros, distribuídas em dois grupos: suplementadas com 500 mg de vitamina C (n=11, e placebo (n=10, durante 45 dias. Modulação autonômica cardíaca foi avaliada por análise espectral da variabilidade da frequência cardíaca em repouso e durante o exercício isométrico. RESULTADOS: crianças obesas, no repouso e durante o exercício isométrico, apresentaram uma maior ativação simpática cardíaca e uma menor atividade vagal. Quando se comparou os componentes espectrais de baixa e alta frequência entre os grupos avaliados, observaram-se diferenças significativas. Após suplementação com vitamina C, os componentes espectrais foram similares àqueles observados nas crianças eutróficas, tanto no repouso como durante o exercício isométrico. CONCLUSÕES: crianças obesas apresentam uma maior atividade simpática e menor atividade vagal no repouso e durante o exercício isométrico quando comparada as crianças eutróficas. Como também, a suplementação oral com vitamina C, em altas doses, pode restaurar a disfunção autonômica cardíaca em crianças obesas.OBJECTIVES: to draw a comparison between obese and eutrophic children regarding cardiac autonomic modulation and to investigate the effect of vitamin C supplements on cardiac autonomic modulation in obese children, at rest and during isometric exercise. METHODS: the study covered eight eutrophic (IMC= 18 ± 1Kg/cm² and 21 obese (IMC = 29 ± 1Kg/cm² children aged between 8 and 11 years of both sexes, distributed into two groups: one receiving a 500 mg vitamin C

  12. Prevention under the Affordable Care Act (ACA: Has the ACA Overpromised and under Delivered?; Comment on “Interrelation of Preventive Care Benefits and Shared Costs under the Affordable Care Act (ACA”

    Carol Molinari

    2014-08-01

    Full Text Available This policy brief discusses preventive care benefits and cost-sharing included in health insurance provisions of the Affordable Care Act (ACA legislation and highlights some consequences to Americans and the country in terms of healthcare costs and value.

  13. Insuficiência cardíaca: estratégias usadas por idosos na busca por qualidade de vida

    Analyane Conceição Silva dos Santos

    2011-10-01

    Full Text Available Estudo descritivo com abordagem qualitativa cujos objetivos foram identificar as repercussões da insuficiência cardíaca na qualidade de vida dos idosos; descrever as estratégias utilizadas no enfrentamento destas repercussões e conhecer as percepções acerca dos cuidados de enfermagem. Foram realizadas entrevistas semiestruturadas com dez idosos com insuficiência cardíaca em um hospital militar do Rio de Janeiro-RJ. Identificou-se que a insuficiência cardíaca gera repercussões emocionais, físicas e financeiras na vida dos idosos, ocasionando impacto na qualidade de vida. Dentre as estratégias criadas pelos idosos, verificou-se o enfrentamento paliativo e o enfrentamento emocional. Os cuidados de enfermagem evidenciados foram orientação, carinho, zelo e dedicação. Cuidar do idoso com insuficiência cardíaca implica em avaliar as repercussões na capacidade funcional e autonomia dos anciãos, exigindo habilidades e competências do enfermeiro para identificar suas especificidades na perspectiva de um cuidado integral que contribua para a qualidade de vida dos mesmos.

  14. Political Ideology and Its Relationship to Perceptions of Social Justice Advocacy among Members of the American Counseling Association (ACA)

    Steele, Janee Marie

    2010-01-01

    Social justice has become an increasingly controversial topic among members of the American Counseling Association (ACA). Specifically, concerns have been raised over what is perceived to be: (a) the liberal political agenda of social justice advocates, (b) the marginalization of conservative counselors, and (c) the inappropriate use of ACA…

  15. Use of aminocaproic acid (ACA in extra-amniotic MTP in patients on anti-coagulant therapy.

    Kale P

    1992-10-01

    Full Text Available A case of rheumatic heart disease (RHD with prosthetic mitral valve endocarditis receiving anticoagulation with heparin, underwent medical termination of pregnancy in a second trimester. The following report entails the use of aminocaproic acid (ACA in preventing excessive bleeding during and after the procedure, while the patient continued to receive anticoagulant therapy.

  16. Taking iron supplements

    ... medlineplus.gov/ency/article/007478.htm Taking iron supplements To use the sharing features on this page, ... levels. You may also need to take iron supplements as well to rebuild iron stores in your ...

  17. Dietary Supplements for Toddlers

    ... Listen Español Text Size Email Print Share Dietary Supplements for Toddlers Page Content Article Body If you ... a diet recommended for children), she may need supplements of vitamins B12 and D as well as ...

  18. Variabilidade da frequência cardíaca em neonatos prematuros e de termo

    Fabio Augusto Selig

    2011-06-01

    Full Text Available FUNDAMENTO: Várias publicações têm demonstrado a importância do sistema nervoso autônomo por meio dos componentes simpático e parassimpático na gerência da interação entre as diferentes partes do organismo humano. Esses estudos aplicaram técnicas lineares e não lineares (Teoria do Caos de avaliação em diferentes situações, doenças e faixas etárias, tendo como ferramenta a variabilidade da frequência cardíaca (VFC. OBJETIVO: Aplicar os conhecimentos das dinâmicas linear e não linear na avaliação de neonatos prematuros (NPT, analisando sua VFC e comparando com neonatos de termo (NT saudáveis. MÉTODOS: Quarenta e oito neonatos prematuros com diferentes idades gestacionais tiveram seus batimentos cardíacos captados com auxílio do equipamento Polar Advanced S810i e sua VFC obtida pelo registro dos intervalos RR. A VFC foi analisada nos domínios do tempo (SDNN, RMSSD, SD1/SD2, da frequência (VLF, LF, HF e a relação LF/HF e do caos (TAU e sua normalização [TAU(n], Expoente de Lyapunov e Entropia. Os NPT foram comparados com um grupo de 78 NT saudáveis e sem intercorrências perinatais com auxílio do teste não paramétrico de Kruskal-Wallis. RESULTADOS: Detectou-se diferença estatisticamente significante entre os grupos para todas as variáveis estudadas, tanto no domínio do tempo como nos da frequência e do caos. CONCLUSÃO: Neonatos prematuros exibem comportamento menos complexo da variabilidade da frequência cardíaca que neonatos de termo, fato comprovado nos domínios do tempo, da frequência e do caos. O estudo da variabilidade cardíaca nesse grupo pode ser considerado uma ferramenta a mais na avaliação da maturação autonômica e, consequentemente, da progressão para eutrofia.

  19. Emerging Supplements in Sports

    Mason, Bryan C.; Lavallee, Mark E.

    2012-01-01

    Context: Nutritional supplements advertised as ergogenic are commonly used by athletes at all levels. Health care professionals have an opportunity and responsibility to counsel athletes concerning the safety and efficacy of supplements on the market. Evidence Acquisition: An Internet search of common fitness and bodybuilding sites was performed to identify supplement promotions. A search of MEDLINE (2000–August, 2011) was performed using the most commonly identified supplements, including gl...

  20. Effects of Supplemental Dietary Phytase and 25-Hydroxycholecalciferol on the Digestive and Reproductive Organ Characteristics of Commercial Layers Inoculated Before or at the Onset of Lay with the F-Strain of Mycoplasma galli

    In 3 trials, the effects of dietary supple mentation with phytase (PHY) and 25-hydroxycholecalciferol (25-D3) on the digestive and reproductive organ characteristics of commercial layers that were inoculated pre-lay (12 wk of age) or at the onset of lay (22 wk of age) with F-strain Mycoplasma gallis...

  1. Manifestações orais da Doença Celíaca em Odontopediatria

    Sousa, Joana Luísa Ribeiro Ferreira Pereira de

    2012-01-01

    Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária A doença celíaca (DC) é uma enteropatia comum, caraterizada pela permanente intolerância ao glúten. Tem sido descrito por vários autores a importância das manifestações orais provocadas por esta doença para um diagnóstico precoce, sendo as mais comuns, defeitos de esmalte, baixa incidência de cárie e ulcerações aftosas recorrentes. ...

  2. Parada cardíaca inesperada durante colecistectomia: relato de caso

    Croitor Lorena Brito da Justa

    2002-01-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A parada cardíaca per-operatória é um evento grave, e sua incidência em nosso serviço é de 31:10.000 anestesias. O objetivo deste relato é apresentar um caso de parada cardíaca durante anestesia geral em uma paciente submetida a colecistectomia. RELATO DO CASO: Paciente feminina, 16 anos, 62 kg, estado físico ASA I, submetida à colecistectomia por via aberta. Midazolam (15 mg por via oral foi a medicação pré-anestésica. Foi realizadas indução anestésica com sufentanil (50 µg, propofol (150 mg e atracúrio (30 mg. A anestesia foi mantida com isoflurano e N2O. Após trinta minutos de cirurgia ocorreu bradicardia sinusal revertida com atropina (0,5 mg. Vinte minutos depois, ocorreu outra bradicardia com bloqueio átrio-ventricular de 3º grau evoluindo rapidamente para parada cardíaca (PCR em assistolia, apesar da administração de atropina (1 mg. As manobras de reanimação foram iniciadas imediatamente, juntamente com a administração de adrenalina (1 mg, com retorno dos batimentos cardíacos espontâneos após aproximadamente cinco minutos da PCR. A cirurgia foi concluída e a paciente manteve-se estável hemodinami- camente. A paciente foi extubada duas horas após o término da cirurgia apresentando-se sonolenta, não contactante, com bom padrão ventilatório e hemodinâmico. Após doze horas de observação na unidade de terapia intensiva (UTI a paciente apresentava-se agitada e desconexa. Vinte e quatro horas após a PCR a paciente recebeu alta da UTI consciente, orientada, sem queixas e sem déficit neurológico. Recebeu alta hospitalar no 4º dia do pós-operatório. CONCLUSÕES: Diversos fatores podem contribuir para a ocorrência de disritmias e parada cardíaca no per-operatório, destacando-se a estimulação vagal secundária às manobras cirúrgicas. O diagnóstico precoce e o rápido início das manobras de reanimação são de fundamental importância para a boa evolução neurol

  3. Grupo de pacientes de cirurgia cardíaca: relato de experiência

    Elisa Helena Kuhn

    1986-09-01

    Full Text Available Neste trabalho relata-se uma experiência de grupo com pacientes de cirurgia cardíaca. A atividade realiza-se no INSTITUTO DE CARDIOLOGIA DO RIO GRANDE DO SUL e tem por objetivo proporcionar aos pacientes a oportunidade de verbalizarem suas ansiedades e conversarem sobre suas experiências relacionadas com a cirurgia e anestesia. Os grupos reúnem-se duas vezes por semana sendo constituídos por pacientes adultos em pré e pós-operatório imediato. A equipe de saúde é composta por enfermeiros, psicólogo, anestesista, cardiologistas e fisioterapeutas e sua atuação é no sentido de auxiliar na compreensão dos procedimentos aos quais o paciente vai se submeter, desfazendo fantasias distorcidas da realidade.

  4. Cansaço do reanimador durante a massagem cardíaca externa

    Preto, Leonel; Novo, André

    2013-01-01

    As recomendações em reanimação têm vindo a dar importância à massagem cardíaca externa realizada com qualidade. O esforço do reanimador tem vindo a ser alvo de alguns estudos que têm vindo a concluir que o cansaço afeta negativamente a qualidade das compressões torácicas. A dosagem sanguínea do lactato é uma forma prática e muito objetiva de se obter uma avaliação do metabolismo do lactato e do limiar anaeróbio e, portanto, um indicador preciso de esforço e fadiga. O objetivo deste trabalho f...

  5. Caquexia associada à insuficiência cardíaca Heart failure-induced cachexia

    Marina Politi Okoshi

    2013-05-01

    Full Text Available Pacientes com insuficiência cardíaca frequentemente desenvolvem estado de caquexia, que constitui fator independente de redução da sobrevida. Caquexia pode ser diagnosticada quando ocorre perda de peso corporal maior que 6% do peso habitual, na ausência de outras doenças. Embora sua fisiopatologia não esteja completamente esclarecida, vários fatores parecem estar envolvidos, como diminuição da ingestão alimentar, anormalidades do trato gastrointestinal, ativação imunológica e neuro-hormonal e alteração da relação entre processos anabólicos e catabólicos. Como não há terapia específica para a caquexia associada à insuficiência cardíaca, o tratamento baseia-se no suporte nutricional, bloqueio neuro-hormonal, controle do edema e anemia e exercícios físicos. Fármacos com propriedades imunomodulatórias e anabólicas encontram-se em investigação clínica e experimental.Heart failure patients often develop cachexia, which is an independent factor for survival reduction. Cachexia can be diagnosed when there is loss of more than 6% of the body weight, in the absence of other diseases. Even though its pathophysiology has not yet been completely clarified, various factors seem to be involved, such as reduction in food consumption, gastrointestinal tract abnormalities, immunologic and neuro-hormonal activarion and changes in the relationship between anabolic and catabolic processes. Since there is not specific therapy for heart failure-induced cachexia, management is based on nutritional support, neuro-hormonal blockade, control of edema and anemia and exercise. Drugs with anabolic and immunomodulating properties are being evaluated and clinical and non-clinical trials.

  6. Psiscan: a computational approach to identify H/ACA-like and AGA-like non-coding RNA in trypanosomatid genomes

    Ziporen Yaara

    2008-11-01

    Full Text Available Abstract Background Detection of non coding RNA (ncRNA molecules is a major bioinformatics challenge. This challenge is particularly difficult when attempting to detect H/ACA molecules which are involved in converting uridine to pseudouridine on rRNA in trypanosomes, because these organisms have unique H/ACA molecules (termed H/ACA-like that lack several of the features that characterize H/ACA molecules in most other organisms. Results We present here a computational tool called Psiscan, which was designed to detect H/ACA-like molecules in trypanosomes. We started by analyzing known H/ACA-like molecules and characterized their crucial elements both computationally and experimentally. Next, we set up constraints based on this analysis and additional phylogenic and functional data to rapidly scan three trypanosome genomes (T. brucei, T. cruzi and L. major for sequences that observe these constraints and are conserved among the species. In the next step, we used minimal energy calculation to select the molecules that are predicted to fold into a lowest energy structure that is consistent with the constraints. In the final computational step, we used a Support Vector Machine that was trained on known H/ACA-like molecules as positive examples and on negative examples of molecules that were identified by the computational analyses but were shown experimentally not to be H/ACA-like molecules. The leading candidate molecules predicted by the SVM model were then subjected to experimental validation. Conclusion The experimental validation showed 11 molecules to be expressed (4 out of 25 in the intermediate stage and 7 out of 19 in the final validation after the machine learning stage. Five of these 11 molecules were further shown to be bona fide H/ACA-like molecules. As snoRNA in trypanosomes are organized in clusters, the new H/ACA-like molecules could be used as starting points to manually search for additional molecules in their neighbourhood. All

  7. Respuesta cardíaca en jugadores de fútbol de tercera división durante partidos oficiales y entrenamientos

    Parra Rojas, Nicolás

    2016-01-01

    Justificación. La frecuencia cardíaca es una de las variables más utilizadas para el registro del compromiso fisiológico de los deportistas. En este sentido, en nuestra investigación se intenta determinar, partiendo de la respuesta cardíaca de los futbolistas, los niveles de intensidad alcanzados por éstos en función del tipo de actividad (entrenamiento o competición) y en función del puesto específico ocupado en el terreno de juego. Objetivos. Analizar la respuesta cardíaca en futbolistas...

  8. Comportamento dos quimiorreflexos central e periférico na insuficiência cardíaca

    Guilherme Veiga Guimarães

    2011-02-01

    Full Text Available A síndrome da insuficiência cardíaca (IC pode ser definida como via final de qualquer forma de doença cardíaca. Os reflexos cardiovasculares simpatoinibitórios como o reflexo arterial barorreceptor estão significativamente suprimidos na IC. Pacientes com IC apresentam maior ventilação para determinada carga de trabalho quando comparados a indivíduos normais. Esse fato gera baixa eficiência ventilatória e relaciona-se com maior ventilação relativa à produção de gás carbônico, que é um preditor de mau prognóstico, além de ser um fator limitante ao exercício. Há evidências de que o desequilíbrio autonômico contribua para a patogênese e a progressão da insuficiência cardíaca. Os quimiorreflexos são os principais mecanismos de controle e regulação das respostas ventilatórias às mudanças de concentração do oxigênio e gás carbônico arterial. A ativação do quimiorreflexo causa aumento da atividade simpática, frequência cardíaca, pressão arterial e volume minuto. No entanto, o aumento do volume minuto e da pressão arterial, pelo feedback negativo provocam inibição da resposta simpática à ativação do quimiorreflexo. Apesar das alterações funcionais dos reflexos, seu comportamento em condições normais e patológicas, especialmente sua contribuição para o estado simpatoexcitatório encontrado na IC, não tem sido amplamente estudado. Dessa forma, esta revisão tem por objetivo integrar os conhecimentos a respeito dos quimiorreflexos central e periférico na síndrome da insuficiência cardíaca, bem como esclarecer a influência da terapêutica medicamentosa da insuficiência cardíaca nos quimiorreflexos.

  9. Fase crônica cardíaca fibrosante da Tripanossomíase cruzi experimental no cão

    Marta de Lana

    1988-09-01

    Full Text Available Os autores documentam a cardiopatia difusa fibrosante, com todos os sintomas clínicos e dados de autópsia pertinentes à insuficiência cardíaca congestiva, em um dos 21 cães infectados com a cepa Colombiana (cinco morreram na fase aguda e quatro continuam vivos e cinco, dos 13 infectados com a cepa Berenice-78 (oito morreram na fase aguda, num período de oito anos de observação. Em vista destes resultados, os autores sugerem que o cão possa vir a ser um modelo experimental, adequado para o estudo da história natural da doença de Chagas, preenchendo os requisitos estabelecidos pelo Comitê Assessor de Doença de Chagas do Programa Especial de Pesquisa e Treinamento em Doenças Tropicais da Organização Mundial de Saúde.The authors found the fibrosing chronic chagasic cardiopathy with congestive heartfailure in one out of the 21 dogs infected with the Colombian strain (five died in acutephase andfour are alivefive out of the 13 animais infected with the Berenice-78 strain eight died in acute phase were observed until eight years of infection with T. cruzi. In view of these results, the author suggest that the dog could be a suitable experimental model for the study of the natural history of Chagas' disease. The dog conforms with the requisites of the World Health Organization (WHO Steering Committee of Chagas' disease of the Programmefor Research Training in Tropical Diseases.

  10. Polimorfismo G894T da óxido nítrico-sintetase endotelial e o prognóstico na insuficiência cardíaca

    2013-01-01

    FUNDAMENTO: Estudos prévios avaliaram o papel do polimorfismo genético da enzima óxido nítrico-sintetase endotelial sobre o prognóstico na insuficiência cardíaca. Entretanto, faltam estudos relacionando o G894T e a insuficiência cardíaca na população brasileira. OBJETIVO: Avaliar a associação do G894T com o prognóstico de amostra de pacientes brasileiros com insuficiência cardíaca. MÉTODOS: Coorte com 145 pacientes com insuficiência cardíaca sistólica, num segmento de 40 meses (média = 22 mes...

  11. Detection and Identification of Probiotic Lactobacillus plantarum Strains by Multiplex PCR Using RAPD-Derived Primers

    Alex Galanis

    2015-10-01

    Full Text Available Lactobacillus plantarum 2035 and Lactobacillus plantarum ACA-DC 2640 are two lactic acid bacteria (LAB strains that have been isolated from Feta cheese. Both display significant potential for the production of novel probiotic food products. The aim of the present study was the development of an accurate and efficient method for the molecular detection and identification of the above strains in a single reaction. A multiplex PCR assay was designed for each strain, based on specific primers derived from Random Amplified Polymorphic DNA (RAPD Sequenced Characterized Amplified Region (SCAR analysis. The specificity of the assay was tested with a total of 23 different LAB strains, for L. plantarum 2035 and L. plantarum ACA-DC 2640. The multiplex PCR assay was also successfully applied for the detection of the above cultures in yogurt samples prepared in our lab. The proposed methodology may be applied for monitoring the presence of these strains in food products, thus evaluating their probiotic character. Moreover, our strategy may be adapted for other novel LAB strains with probiotic potential, thus providing a powerful tool for molecular discrimination that could be invaluable to the food industry.

  12. Detection and Identification of Probiotic Lactobacillus plantarum Strains by Multiplex PCR Using RAPD-Derived Primers

    Galanis, Alex; Kourkoutas, Yiannis; Tassou, Chrysoula C.; Chorianopoulos, Nikos

    2015-01-01

    Lactobacillus plantarum 2035 and Lactobacillus plantarum ACA-DC 2640 are two lactic acid bacteria (LAB) strains that have been isolated from Feta cheese. Both display significant potential for the production of novel probiotic food products. The aim of the present study was the development of an accurate and efficient method for the molecular detection and identification of the above strains in a single reaction. A multiplex PCR assay was designed for each strain, based on specific primers derived from Random Amplified Polymorphic DNA (RAPD) Sequenced Characterized Amplified Region (SCAR) analysis. The specificity of the assay was tested with a total of 23 different LAB strains, for L. plantarum 2035 and L. plantarum ACA-DC 2640. The multiplex PCR assay was also successfully applied for the detection of the above cultures in yogurt samples prepared in our lab. The proposed methodology may be applied for monitoring the presence of these strains in food products, thus evaluating their probiotic character. Moreover, our strategy may be adapted for other novel LAB strains with probiotic potential, thus providing a powerful tool for molecular discrimination that could be invaluable to the food industry. PMID:26506345

  13. [Peptide mapping of the major proteins in 2 strains of influenza virus].

    Savich, I M; Gerasimova, L M; Mertvetsov, N P

    1985-01-01

    The protein composition of two influenza A virus strains from different serological groups was studied. For preliminary separation of envelope and core proteins the virus was treated with nonionic detergent Triton X-100 solution followed by chromatography in ultragel AcA 34. After their separation by disk electrophoresis and treatment with trypsin they were labeled with tritium and peptide analysis was carried out. Differences in peptide maps between the appropriate light and heavy chains of hemagglutinins of the strains under study were demonstrated. Differences in the composition of nucleoprotein and matrix protein were insignificant. PMID:3922120

  14. Treinamento físico na distrofia muscular de becker associada à insuficiência cardíaca

    Jean Marcelo Roque

    2011-12-01

    Full Text Available A distrofia muscular de Becker (DMB integra as distrofinopatias que ocorrem devido a mutações genéticas que expressam a proteína distrofina no cromossomo X. O início dos sintomas neuromusculares normalmente precede o comprometimento da função cardíaca, podendo acontecer inversamente pela insuficiência cardíaca (IC. O treinamento físico é bem estabelecido na IC, porém, quando associada à DMB, é controverso e sem fundamento científico. Apresentamos o caso de um paciente com DMB associada à IC em fila de transplante cardíaco submetido a um programa de treinamento físico.

  15. Realidad de la cirugía cardíaca en la República Argentina. Registro CONAREC XVI

    Diego M. Lowenstein Haber; Fernando M. Guardiani; Pablo Pieroni; Lisandro Pfister; Laura Carrizo; Esteban D. Villegas; María F. Renedo; Federico J. Landeta; Jorge Thierer

    2010-01-01

    RESUMENIntroducciónLos dos grandes registros multicéntricos de cirugía cardíaca realizados en la Argentina,CONAREC y ESMUCICA, datan de más de 10 años. Considerando los avances médicosy quirúrgicos de la última década, surgió la necesidad de realizar un nuevo registronacional, prospectivo y multicéntrico para conocer las características, la evolución, lascomplicaciones y los predictores de mortalidad de los pacientes sometidos a cirugía cardíaca.ObjetivosConocer el perfil epidemiológico, la m...

  16. Mediastinite pós-esternotomia longitudinal para cirurgia cardíaca: 10 anos de análise

    Valdir Cesarino de Souza; André Ney Menezes Freire; José Tavares-Neto

    2002-01-01

    INTRODUÇÃO: mediastinites pós-esternotomia para cirurgia cardíaca não são freqüentes (0,2% a 5,0%), porém, quando surgem, se tornam potencialmente graves. Mesmo com o diagnóstico e tratamento precoces, o prognóstico não é bom, sobretudo se houver sepse e outros agravos à saúde associados. OBJETIVO: rever a casuística de casos de mediastinite. MÉTODO: foram analisados os prontuários de 2.272 pacientes submetidos à cirurgia cardíaca entre 1991 e 2000. Todas as operações foram realizadas através...

  17. 一种新的混合并行蚁群算法研究应用%Research on a new hybrid parallel ACA

    王磊

    2012-01-01

    提出了一种新的混合并行蚁群算法,在单机多核机及多核集群机下分别实现了MPI并行蚁群算法及MPI+ TBB并行蚁群算法,应用于真实路网车辆路径问题(Vehicle Routing Problem,VRP),对两者进行了实验对比,实验结果表明MPI并行蚁群算法具有较高的加速比,和问题规模关系不大,刚开始呈现线性加速比.较MPI并行蚁群算法,MPI+ TBB混合并行蚁群算法具有更好的可扩展性,在进程数较多时仍具有较高的加速比.%A new hybrid parallel ant colony algorithm (ACA) is presented, respectively construct MPI parallel ACA and MPI + TBB parallel ACA in the multi-core single machine and multi-core clusters to apply to the real road network for vehicle routing problem ( VRP). The experimental results show that MPI based parallel ACA make higher speedup , have nothing to do with problem size, and show linear speedup at the beginning. MPI + TBB based parallel hybrid parallel ACA has better scalability and a more high speedup than the MPI based parallel ACA in the more processes.

  18. Seguridad del paciente en el postoperatorio de cirugía cardíaca en UCI

    Álvarez Menéndez, Katia

    2013-01-01

    Describir las medidas de seguridad del paciente que se adoptan en el postoperatorio de cirugía cardíaca en UCI y comprobar que dichas medidas de seguridad del paciente son efectivas y proporcionan beneficios a los pacientes. Para ello se describen todos los protocolos y dispositivos específicos y se comparan los resultados obtenidos en cuanto a los protocolos de Neumonía Zero y Bacteriemia Zero.

  19. Enzymatic activity and immunoreactivity of Aca s 4, an alpha-amylase allergen from the storage mite Acarus siro

    Pytelková, Jana; Lepšík, Martin; Šanda, Miloslav; Talacko, Pavel; Marešová, Lucie; Mareš, Michael

    2012-01-01

    Roč. 13, č. 3 (2012), s. 1-8. ISSN 1471-2091 R&D Projects: GA ČR GP525/09/P600 Institutional research plan: CEZ:AV0Z40550506 Keywords : Aca s 4 * Acarus siro * alpha- amylases Subject RIV: CE - Biochemistry Impact factor: 1.776, year: 2012 http://www.biomedcentral.com/1471-2091/13/3

  20. The Impact of Market Size and Composition on Health Insurance Premiums: Evidence from the First Year of the ACA

    Michael J. Dickstein; Mark Duggan; Joseph Orsini; Pietro Tebaldi

    2015-01-01

    Under the Affordable Care Act, individual states have discretion in how they define coverage regions, within which insurers must charge the same premium to buyers of the same age, family structure, and smoking status. We exploit variation in these definitions to investigate whether the size of the coverage region affects outcomes in the ACA marketplaces. We find large consequences for small and rural markets. When states combine small counties with neighboring urban areas into a single region...

  1. Identification and evolutionary implication of four novel box H/ACA snoRNAs from Giardia lamblia

    LUO Jun; ZHOU Hui; CHEN Chongjian; LI Yan; CHEN Yueqin; QU Lianghu

    2006-01-01

    From a specialized cDNA library, four novel box H/ACA snoRNAs, named GLsR22,GLsR23, GLsR24 and GLsR25, were identified from the primitive eukaryote, Giardia lamblia. Bioinformatics analyses indicated that all of them can be potentially folded into double hairpins, the typical secondary structures of box H/ACA snoRNAs. GLsR24 and GLsR25 are predicted to guide the site-specific pseudouridylation at U1753 and U2396 on 23S rRNA,respectively, while GLsR22 and GLsR23 belong to the family of "orphan" snoRNAs. All of the four novel snoRNAs are encoded by single copy genes and located in small intergenic regions. Interestingly,compared with the counterparts previously reported in Archaea and other unicellular protozoan, the box H/ACA snoRNAs identified from G. lamblia have unique structural features, implying that snoRNAs evolved from prokaryotes to eukaryotes in different ways.

  2. Muerte súbita por conmoción cardíaca (Commotio cordis asociada a miocardio no compactado

    Analía Aquieri

    2011-12-01

    Full Text Available El miocardio no compactado es una rara miocardiopatía congénita caracterizada por la presencia de múltiples y prominentes trabeculaciones profundas en la pared ventricular que definen hendiduras comunicantes con el compartimiento ventricular principal. Es una entidad de baja incidencia y prevalencia que se diagnostica mediante estudios de imágenes como el ecocardiograma Doppler (ED, la tomografía computarizada multicorte (TCM y la resonancia magnética cardíaca (RMC. Puede ser asintomática o manifestarse mediante arritmias, insuficiencia cardíaca o eventos tromboembólicos. Se presenta el caso de un hombre de 33 años, asintomático, que durante la práctica deportiva sufre una conmoción cardíaca (commotio cordis que le produce un paro cardiorrespiratorio. El electrocardiograma mostró un ritmo de aleteo ventricular que requirió cardiodesfibrilación eléctrica. En un ED efectuado inicialmente no se observaron anormalidades significativas, pero otro ED, una TCM y una RMN obtenidos luego del alta, certificaron el hallazgo de miocardio no compactado aislado, descartando coronariopatía. Recibió tratamiento beta bloqueante y antiagregante y se discutió la colocación del cardiodesfibrilador implantable. Se plantea la fisiopatología de la asociación de estas dos infrecuentes y potencialmente letales afecciones.

  3. Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies.

    Vogan, Jacob M; Zhang, Xiaozhu; Youmans, Daniel T; Regalado, Samuel G; Johnson, Joshua Z; Hockemeyer, Dirk; Collins, Kathleen

    2016-01-01

    We dissected the importance of human telomerase biogenesis and trafficking pathways for telomere maintenance. Biological stability of human telomerase RNA (hTR) relies on H/ACA proteins, but other eukaryotes use other RNP assembly pathways. To investigate additional rationale for human telomerase assembly as H/ACA RNP, we developed a minimized cellular hTR. Remarkably, with only binding sites for telomerase reverse transcriptase (TERT), minimized hTR assembled biologically active enzyme. TERT overexpression was required for cellular interaction with minimized hTR, indicating that H/ACA RNP assembly enhances endogenous hTR-TERT interaction. Telomere maintenance by minimized telomerase was unaffected by the elimination of the telomerase holoenzyme Cajal body chaperone TCAB1 or the Cajal body scaffold protein Coilin. Surprisingly, wild-type hTR also maintained and elongated telomeres in TCAB1 or Coilin knockout cells, with distinct changes in telomerase action. Overall, we elucidate trafficking requirements for telomerase biogenesis and function and expand mechanisms by which altered telomere maintenance engenders human disease. PMID:27525486

  4. FERMENTATION EFFICIENCY OF YEAST ISOLATES AND THE EFECT OF NUTRIENT SUPPLEMENTS

    HELEN SOIBAM1, AYAM VICTOR SINGH2, IVI CHAKRABORTY3

    2014-12-01

    Full Text Available ABSTRACT: Wine is one of the end products of fermentation of respiratory substrates, while, yeast is one of the principal fermenting microorganisms. Changes in the substrate composition and yeast strains could vary in the quality of the wine. Two yeast isolates (Y4 and Y7 from date palm juice and standard yeast “Y33”,an isolate of Saccharomyces cerevisiae (MTCC-170 from Institute of MicrobiAl Technology, IMTECH, Chandigarh where used for studying the comparative fermentation of Molasses without nutrient supplementation, and separately with nutrient supplementation by KH2PO4 and NaNO3 @ 1g/l. Though, with nutrient supplement KH2PO4, Y33 yields higher alcohol%, both Y4 and Y7 strains produce wine with better efficiency and acceptability without the nutrient supplements unlike Y33 strains. All the three strains impart better flavour and colour in the medium without nutrient supplement in terms of hedonic scale. Further, Y4 yields higher alcohol than Y7 and Y33. Therefore, palm juice yeast isolates particularly, Y4 strains show the highest overall fermentation efficiency and acceptability among the three yeasts isolates, moreover, since its highest efficiency occurs in the absence of nutrient supplementation, unlike the standard strain, it can be recommendedas a better substitute of the standard Y33 strains. KEY WORDS: Fermentation, Yeast,  Nutrient supplements.

  5. Freqüência cardíaca e risco cardiovascular Heart rate and cardiovascular risk

    Luiz Antonio Machado César

    2007-10-01

    Full Text Available A freqüência cardíaca (FC também está no centro das determinantes do tempo de vida dos seres vivos animais. Há quase uma constante quando se multiplica a FC pelo número de anos que, em média, vive um animal. O ser humano também tem correlações interessantes de tempo de vida e FC, com estudos epidemiológicos demonstrando maior sobrevivência naqueles com menor FC em repouso, hipertensos, com doença coronariana e na população geral. Neste artigo, revemos estes estudos epidemiológicos e a perspectiva de se, de fato reduzindo a FC, poderemos aumentar o tempo de vida, no caso dos pacientes com doença cardiovascular, de forma independente de outros fatores.Heart rate (HR is known to be one of the factors that in the animal world are related to mortality. When one multiplies resting HR by the average life time, for each animal species, the result is almost the same number, similar to a constant. Apparently, each class of living beings has its "maximal number of heart beats for a life". Herein considerations are made about the relationship between HR and survival in human beings. Some epidemiological studies are reviewed, especially those related to cardiovascular and coronary diseases correlated to deaths and discussions are directed towards the perspective of living longer by lowering the HR.

  6. Anemia nos pacientes com insuficiência cardíaca avançada

    Juliano Cardoso

    2010-10-01

    Full Text Available FUNDAMENTO: Anemia está associada à pior evolução nos pacientes com insuficiência cardíaca (IC. Entretanto, há poucos estudos sobre a anemia nos pacientes com IC avançada. OBJETIVO: Avaliar as características da anemia na IC em fase avançada. MÉTODOS: Foram incluídos 99 pacientes hospitalizados para compensação de IC (CF IV/NYHA, com idade > 18 anos e FEVE 12 g/dl. A anemia foi marcador independente de mau prognóstico na análise multivariada (mortalidade 47% vs 24,6%, p = 0,016, risco relativo 2,54. CONCLUSÃO: Anemia acomete, aproximadamente, 1/3 dos pacientes com IC avançada, e a deficiência de ferro é uma importante etiologia. Pacientes anêmicos são mais idosos e apresentaram função renal mais deteriorada. A melhora da congestão não foi suficiente para melhorar a anemia na maioria dos casos. Nos pacientes com IC avançada, a anemia é marcador independente de mau prognóstico.

  7. Manifestaciones digestivas y extradigestivas de la enfermedad celíaca.

    Luis Ortigosa

    2009-11-01

    Full Text Available La enfermedad celíaca (EC es una enteropatía de base autoinmune que se manifiesta en sujetos genéticamente susceptibles, asociada con genes que codifican para las moléculas HLA DQ2 (DQ A1*0501/DQB1*0201 y DQ8 (DQA1*0301/ DQB1*0302. Se caracteriza por una respuesta inmunológica a la ingesta del gluten de trigo y otras prolaminas relacionadas del centeno y la cebada. Las manifestaciones clínicas son diversas, puede haber formas sintomáticas digestivas “clásicas” en niños, y formas extradigestivas en personas de todas las edades. Las manifestaciones atípicas y extradigestivas contribuyen cada vez más a dificultar y demorar el diagnóstico de EC. El uso de marcadores serológicos, especialmente los anticuerpos contra la transglutaminasa tisular, facilita el proceso diagnóstico inicial, que se debe confirmar con una biopsia intestinal para poner de manifiesto unas lesiones histológicas características, con grados variables de atrofia vellositaria, hiperplasia de las criptas e infiltrado linfocitario.

  8. Os efeitos da trimetazidina na variabilidade da frequência cardíaca (VFC em pacientes com insuficiência cardíaca Los efectos de la trimetazidina en la variabilidad de la frecuencia cardíaca (VFC en pacientes con insuficiencia cardíaca The effects of trimetazidine on heart rate variability in patients with heart failure

    Yilmaz Gunes

    2009-08-01

    Full Text Available FUNDAMENTO: Tem sido demonstrado que diminuições na variabilidade da frequência cardíaca (VFC estão relacionadas com o prognóstico na insuficiência cardíaca (IC. A administração crônica de trimetazidina, além da terapia convencional, tem melhorado a classe funcional e a função ventricular esquerda de pacientes com IC. OBJETIVO: Avaliar os efeitos da trimetazidina na VFC em pacientes com IC de origem isquêmica, recebendo tratamento otimizado. MÉTODOS: Trimetazidina 20 mg 3 vezes/dia foi adicionada à terapia de 30 pacientes com IC tratados com inibidores da enzima conversora de angiotensinogênio ou bloqueadores do receptor da angiotensina, carvedilol, espironolactona, digital e furosemida. A etiologia da IC era doença arterial coronariana em todos os pacientes. Os pacientes foram avaliados através de ecocardiografia e análise da VFC de 24-horas antes e 3 meses depois da adição de trimetazidina. RESULTADOS: A fração de ejeção ventricular esquerda (FEVE média aumentou significantemente após a adição da trimetazidina (33,5±5,1% para 42,5±5,8%, pFUNDAMENTO: Se ha demostrado que disminuciones en la variabilidad de la frecuencia cardíaca (VFC están relacionadas con el pronóstico en la insuficiencia cardíaca (IC. La administración crónica de trimetazidina, además de la terapia convencional, ha mejorado la clase funcional y la función ventricular izquierda de pacientes con IC. OBJETIVO: Evaluar los efectos de la trimetazidina en la VFC en pacientes con IC de origen isquémico, recibiendo tratamiento optimizado. MÉTODOS: Se agregó trimetazidina 20 mg 3 veces/día a la terapia de 30 pacientes con IC tratados con inhibidores de la enzima conversora de angiotensinógeno o bloqueadores del receptor de la angiotensina, carvedilol, espironolactona, digital y furosemida. La etiología de la IC era enfermedad arterial coronaria en todos los pacientes. Los pacientes fueron evaluados mediante ecocardiografía y análisis de

  9. Women's Health Coverage Since the ACA: Improvements for Most, But Insurer Exclusions Put Many at Risk.

    Palanker, Dania; Davenport, Karen

    2016-08-01

    Issue: Since enactment of the Affordable Care Act (ACA), many more women have health insurance than before the law, in part because it prohibits insurer practices that discriminate against women. However, gaps in women's health coverage persist. Insurers often exclude health services that women are likely to need, leaving women vulnerable to higher costs and denied claims that threaten their economic security and physical health. Goal: To uncover the types and incidence of insurer exclusions that may disproportionately affect women's coverage. Method: The authors examined qualified health plans from 109 insurers across 16 states for 2014, 2015, or both years. Key findings and conclusions: Six types of services are frequently excluded from insurance coverage: treatment of conditions resulting from noncovered services, maintenance therapy, genetic testing, fetal reduction surgery, treatment of self-inflicted conditions, and preventive services not covered by law. Policy change recommendations include prohibiting variations within states' "essential health benefits" benchmark plans and requiring transparency and simplified language in plan documents. PMID:27483555

  10. Cirurgia cardíaca no idoso Cardiac surgery in elderly patients

    Danton R. da Rocha LOURES

    2000-03-01

    Full Text Available Com o aumento da expectativa de vida da população brasileira cresce o número de pessoas com idade superior a 70 anos que necessitam de operação cardíaca. CASUÍSTICA E MÉTODOS: Foram avaliados, retrospectivamente, 75 pacientes com idade 3 a 70 anos submetidos a operação cardíaca no HC-UFPR, entre 1995 e 1999, com objetivo de analisarmos os resultados imediatos e tardios. A idade variou de 70 a 88 anos, sendo 34 (46,7% do sexo feminino e 41 (53,3% do masculino. Os principais sintomas foram angina (81,3%, dispnéia (42,6% e síncope (16%. Os pacientes encontravam-se em classe I (57,3%, classe II (17,3%, classe III (18,6% e classe IV (6,6% da NYHA, 61,3% eram hipertensos, 48% tabagistas, 28% diabéticos e 9,3% haviam sido submetidos a operação cardíaca prévia. Foram realizadas 50 (66,6% revascularizações do miocárdio, 9 (12% trocas de valva aórtica, 5 (6,6% operações de aorta, 4 (5,2% trocas valvares + revascularização miocárdica e outros procedimentos (7%. As principais complicações pós-operatórias foram cardiovasculares: arritmias ventriculares (22,6%, arritmias supraventriculares (21,3%, baixo débito cardíaco (16%; infecciosas (16% e pulmonares (9,3%. O tempo médio de permanência na UTI foi de 5 dias. RESULTADOS: A mortalidade hospitalar foi de 13,3% e houve 5 óbitos tardios. Dos sobreviventes, 78,4% compareceram para seguimento ambulatorial. O tempo médio de seguimento foi de 20,7 meses e a sobrevida foi de 92%; um dos óbitos tardios foi de origem cardiovascular. CONCLUSÃO: Apesar de serem pacientes de maior complexidade clínica pela maior incidência de doenças crônicas e acometimento de outros órgãos, os avanços na cirurgia cardíaca e terapia intensiva tornaram possível a intervenção com baixa morbi-mortalidade.BACKGROUND: Because of the increase in the life expectancy of the Brazilian population, elderly patients are being increasingly referred to cardiac surgery. MATERIAL AND METHODS: Seventy

  11. Resonancia magnética cardíaca: aplicaciones clínicas Cardiac magnetic resonance: clinical applications

    G. Bastarrika

    2005-04-01

    Full Text Available La enfermedad cardiovascular es la causa más frecuente de mortalidad en los países desarrollados y constituye un grave problema social, económico y sanitario. Aunque existen muy diversas técnicas útiles para diagnosticar las enfermedades cardíacas, con frecuencia es preciso realizar más de una prueba para llegar a un diagnóstico concreto. La resonancia magnética es una técnica inocua, bien tolerada y segura que actualmente se encuentra disponible en la mayoría de los centros hospitalarios. Esta técnica permite estudiar en una única exploración la anatomía del corazón y valorar de forma cualitativa, semicuantitativa y cuantitativa los parámetros de función cardíaca. Es útil para el estudio de las enfermedades valvulares, miocardiopatías y de la enfermedad pericárdica. Aporta información de la anatomía y función cardíaca y vascular en las cardiopatías congénitas complejas. Además, con la administración de contraste intravenoso, permite conocer la viabilidad miocárdica en la cardiopatía isquémica. Por tanto, la resonancia magnética cardíaca se perfila como una de las técnicas más prometedoras para el estudio de la patología cardíaca congénita y adquirida.Cardiovascular disease is the most frequent cause of mortality in the developed countries and represents a serious social, economic and health problem. Although very diverse, useful techniques exist for diagnosing cardiac diseases, it is frequently necessary to ask for more than one test to reach a specific diagnosis. Magnetic resonance is a harmless, well tolerated and safe technique, which is currently available in the majority of hospitals. This technique makes it possible in a single exploration to study the anatomy of the heart and to make a qualitative, semi-quantitative and quantitative assessment of the parameters of cardiac function. It provides information of cardiac and vascular anatomy and function in complex congenital cardiopathies. Besides

  12. Infusión intermitente de inotrópicos en la insuficiencia cardíaca avanzada

    Héctor O Ventura

    2001-08-01

    Full Text Available Es conveniente seleccionar adecuadamente a los pacientes en los que se administrará terapia con agentes inotrópicos. Se deben descartar potenciales causas reversibles de insuficiencia cardíaca y evaluar factores que puedan precipitar una descompensación. Los pacientes deben estar tratados con dosis máximas de medicamentos convencionales. Los niveles electrolíticos, especialmente potasio y magnesio deben ser controlados periódicamente con el fin de evitar arritmias, manteniendo el potasio por encima de 4mEq/L y el magnesio por encima de 2mEq/L, y evitar que los niveles de digoxina sean mayores de 2ng/dl. Deben seguir adecuadamente las instrucciones médicas y ser dotados de una educación adecuada acerca de su enfermedad junto con sus familiares cercanos. En conclusión, las indicaciones para el uso de agentes inotrópicos en el tratamiento de insuficiencia cardíaca avanzada deberían estar limitadas a: 1. Pacientes que estén en espera de trasplante cardíaco en los que se pueda utilizarlos como un puente hasta que sean trasplantados. 2. Se puede utilizarlos a corto plazo después de cirugía cardíaca para dar un soporte adecuado, hasta que el corazón del paciente comience a funcionar adecuadamente. 3. Como ya hemos discutido extensamente, se pueden utilizar en pacientes con insuficiencia cardíaca inestable y refractaria, como un puente hacia el uso de beta bloqueantes. 4. En pacientes con descompensación aguda. 5. Finalmente se deberían utilizar en pacientes con insuficiencia cardíaca avanzada y que no son candidatos a trasplante cardíaco, en los cuales es indispensable brindarles una calidad de vida mas digna. Idealmente, deben ser los pacientes los que escojan entre un tipo de medicamento que puede mejorar sus síntomas, pero a expensas de una disminución de su sobrevida. Es decir, poder escoger entre calidad versus cantidad.

  13. Supplemental instruction in chemistry

    Lundeberg, Mary A.

    This study was designed to measure some effects of supplemental instruction in chemistry. Supplemental instruction is a peer-led cooperative learning program that encourages students to develop conceptual understanding by articulating both understandings and misconceptions in a think-aloud fashion. Supplemental instruction was offered three hours weekly outside of class and lab time for students in four classes of General Organic and Biological Chemistry. Over a two-year period 108 students volunteered to participate in this program; 45 students did not participate. As measured by final grades in chemistry and responses to a questionnaire, supplemental instruction was effective in increasing students' achievement in chemistry. Further research is needed to determine the in-depth effects of supplemental instruction on students' learning, problem solving, and self-esteem.

  14. Herbs, Supplements and Alternative Medicines

    ... Size: A A A Listen En Español Herbs, Supplements and Alternative Medicines It is best to get ... also more likely to use dietary supplements. Using Supplements Safely If you’re one of the many ...

  15. On closed weak supplemented modules

    ZENG Qing-yi; SHI Mei-hua

    2006-01-01

    A module M is called closed weak supplemented if for any closed submodule N of M, there is a submodule K of M such that M=K+N and K(c)N<<M. Any direct summand of closed weak supplemented module is also closed weak supplemented.Any nonsingular image of closed weak supplemented module is closed weak supplemented. Nonsingular V-rings in which all nonsingular modules are closed weak supplemented are characterized in Section 4.

  16. Dietary supplements in sport.

    Burke, L M; Read, R S

    1993-01-01

    Studies of the dietary practices of athletes report that nutritional supplements are commonly used. Supplementation practices vary between sports and individual athletes; however, there is evidence that at least some athletes use a large number of supplements concurrently, often in doses that are very high in comparison with normal dietary intakes. In exploring supplementation practices we propose a classification system separating the supplements into dietary supplements and nutritional erogogenic aids. The dietary supplement is characterised as a product which can be used to address physiological or nutritional issues arising in sport. It may provide a convenient or practical means of consuming special nutrient requirements for exercise, or it may be used to prevent/reverse nutritional deficiencies that commonly occur among athletes. The basis of the dietary supplement is an understanding of nutritional requirements and physiological effects of exercise. When the supplement is used to successfully meet a physiological/nutritional goal arising in sport it may be demonstrated to improve sports performance. While there is some interest in refining the composition or formulation of some dietary supplements, the real interest belongs to the use or application of the supplement; i.e. educating athletes to understand and achieve their nutritional needs in a specific sports situation. The sports drink (carbohydrate-electrolyte replacement drink) is a well known example of a dietary supplement. Scientific attitudes towards the sports drink have changed over the past 20 years. Initial caution that carbohydrate-electrolyte fluids compromise gastric emptying during exercise has now been shown to be unjustified. Numerous studies have shown that 5 to 10% solutions of glucose, glucose polymers (maltodextrins) and other simple sugars all have suitable gastric emptying characteristics for the delivery of fluid and moderate amounts of carbohydrate substrate. The optimal

  17. Cardiología intervencionista en arritmias cardíacas: experiencia inicial

    Oswaldo Gutiérrez

    2000-04-01

    Full Text Available Introducción. La cateterización del corazón en electrofisiología se ha venido utilizando con fines diagnósticos y para establecer el recorrido anatómico de las taquicardias supraventriculares o ventriculares y así detectar zonas críticas suceptibles de ablación. El objetivo de este estudio es brindar una revisión de los casos realizados desde febrero de 1999 hasta la fecha, en el país. Materiales y Métodos. Se incluyeron pacientes que tuvieran las indicaciones usuales para realizar estudio electrofisiológico diagnóstico o procedimientos de ablación por catéter. Se colocaron múltiples catéteres intracardíacos para el registro y estimulación de las cámaras cardíacas así como para la aplicacion de radiofrecuencia. Resultados. Se realizaron 19 estudios (5 diagnósticos y 14 terapéuticos, edades entre 16 y 86 años, 6 hombres y 12 mujeres. Los estudios diagnósticos se realizaron en 3 pacientes con síncope, uno con taquicardia ventricular sostenida y uno con extrasistolia ventricular frecuente. Los procedimientos terapéuticos se realizaron en 3 pacientes con reentrada intranodal (éxito 100%, en 10 con vías accesorias o síndrome de Wolff-Parkinson-White (éxito de 90% y en una se realizó ablación del nódulo Aurículoventricular (100% por crisis de fibrilación auricular de alta respuesta ventricular. Ocurrió recidiva en un caso (seguimiento de 2 a 38 semanas y una complicación en otro (derrame pericárdico. Conclusiones. Estos procedimientos de Cardiología Intervencionista en Arritmias Cardíacas son seguros, aportan información diagnóstica relevante y/o tratamiento curativo con alta tasa de éxito y baja tasa de recurrencia en pacientes con diversos trastornos del ritmo cardíaco.Introduction. Electrophysiological cardiac catheterization have been used for diagnostic purposes and for detection of anatomic circuits of different taquiarrhythmias, suitable for ablation procedures. The objetive of this study is to

  18. Interrelation of Preventive Care Benefits and Shared Costs under the Affordable Care Act (ACA

    Robert Dixon

    2014-08-01

    Full Text Available With the implementation of the Affordable Care Act (ACA, access to insurance and coverage of preventive care services has been expanded. By removing the barrier of shared costs for preventive care, it is expected that an increase in utilization of preventive care services will reduce the cost of chronic diseases. Early detection and treatment is anticipated to be less costly than treatment at full onset of chronic conditions. One concern of early detection of disease is the cost to treat. In reality, the confluence of early detection may result in greater overall expenditures. Even with improved access to preventive care benefits, cost-sharing of other health services remains a major component of insurance plans. In order to treat identified conditions or diseases, cost-sharing comes into play. With the greater adoption of cost-sharing insurance plans, expenditures on the part of enrollee are anticipated to rise. Once the healthcare recipients realize the implication of early identification and resultant treatment costs, enrollment in preventive care may decline. Healthcare legislation and regulation should consider the full spectrum of care and the microeconomic costs associated with preventive treatment. Although the system at large may not realize the immediate impact, behavioral shifts on the part of healthcare consumers may alter healthcare. Rather than the current status quo of treating presenting conditions, preventive treatment is largely anticipated to require more resources and may impact the consumer’s financial capacity. This report will explore how these two concepts are co-dependent, and highlight the need for continued reform.

  19. Cirurgia cardíaca na gravidez Cardiac surgery during pregnancy

    Antoninho Sanfins Arnoni

    1986-08-01

    Full Text Available No Instituto Dante Pazzanese de Cardiologia, vem sendo realizado, desde 1975, um trabalho conjunto reunindo obstetras, pediatras, cardiologistas, anestesistas e cirurgiões cardiovasculares, com o intuito de melhorar os resultados da cirurgia cardíaca realizada em pacientes grávidas. Para isto, organizamos um protocolo, que inclui desde o pré-operatório até o nascimento da criança, passando por estudos ecocardiográficos, ultrassonográficos e por monitorização fetal durante a cirurgia. Vinte e seis pacientes foram operadas durante a gravidez, sendo 6 delas em 1985, após o início do estudo. Os resultados, tanto do lado materno como do fetal, são bons, não ocorrendo nenhum óbito materno nesta série e com as crianças nascendo bem e sem malformações e com crescimento e desenvolvimento normais, até o 6º mês de vida extra-uterina.At the Instituto Dante Pazzanese de Cardiologia, a team project has been carried out since 1975, including obstetricians, pediatricians, cardiologists, anesthesiologists and cardiovascular surgeons aim at getting better results of cardiac surgery in pregnant women. For this purpose, the group developed a protocol that goes from the preoperative period to the delivery of the baby, with ecocardiographic and ultrasonic studies and fetal monitoring during the cardiac surgery of the mother. Twenty six patients were submited to cardiac surgery during pregnancy, and six patients after beginning the study, in 1985. The maternal and fetal results were good, without maternal death and the children were born without malformations and having had normal development until the sixth month of life.

  20. Improved performance of P3HT:PCBM solar cells by both anode modification and short-wavelength energy utilization using Tb(aca)3phen

    The performance of P3HT:PCBM solar cells was improved by anode modification using spin-coated Tb(aca)3phen ultrathin films. The modification of the Tb(aca)3phen ultrathin film between the indium tin oxide (ITO) anode and the PE-DOT:PSS layer resulted in a maximum power conversion efficiency (PCE) of 2.99% compared to 2.66% for the reference device, which was due to the increase in the short-circuit current density (Jsc). The PCE improvement could be attributed to the short-wavelength energy utilization and the optimized morphology of the active layers. Tb(aca)3phen with its strong down-conversion luminescence properties is suitable for the P3HT:PCBM blend active layer, and the absorption region of the ternary blend films is extended into the near ultraviolet region. Furthermore, the crystallization and the surface morphology of P3HT:PCBM films were improved with the Tb(aca)3phen ultrathin film. The ultraviolent—visible absorption spectra, atomic force microscope (AFM), and X-ray diffraction (XRD) of the films were investigated. Both anode modification and short-wavelength energy utilization using Tb(aca)3phen in P3HT:PCBM solar cells led to about a 12% PCE increase. (interdisciplinary physics and related areas of science and technology)

  1. Relación entre los índices de funcionalidad cardíaca y cognitiva en personas mayores institucionalizadas

    Carmen Requena Hernández

    2014-12-01

    Full Text Available Los datos más recientes sugieren que la disfunción cardíaca, cuantificada por el gasto cardíaco, está relacionada con el funcionamiento cognitivo. Objetivo: determinar si el funcionamiento cardíaco actúa como predictor de la función cognitiva en personas institucionalizadas con índice cardíaco normal. Método: estudio observacional con una muestra de 30 sujetos mayores de 80 años, con historial médico clínico sin cardiopatías. Resultados: el análisis de regresión múltiple confirma que las variables cardíacas de riesgo cardiovascular e insuficiencia cardíaca son predictoras del nivel de funcionamiento cognitivo y acumulan un 95,1% de la varianza. Sin embargo, destaca la notable falta de correspondencia entre las medidas clínicas cardíacas y cognitivas con la medida biológica de índice cardíaco. Conclusión: aunque los datos observacionales no pueden establecer causalidad, nuestros resultados muestran que la función cardíaca con índice cardíaco normal se asocia con deterior cognitivo

  2. Breastfeeding: Vitamin D Supplementation

    ... Weight Breastfeeding Micronutrient Malnutrition State and Local Programs Vitamin D Supplementation Recommend on Facebook Tweet Share Compartir ... not provide infants with an adequate intake of vitamin D. Most breastfed infants are able to synthesize ...

  3. Iron supplements (image)

    The mineral iron is an essential nutrient for humans because it is part of blood cells, which carry oxygen to all body cells. There is no conclusive evidence that iron supplements contribute to heart attacks.

  4. Antioxidant supplements and mortality

    Bjelakovic, Goran; Nikolova, Dimitrinka; Gluud, Christian

    2014-01-01

    Oxidative damage to cells and tissues is considered involved in the aging process and in the development of chronic diseases in humans, including cancer and cardiovascular diseases, the leading causes of death in high-income countries. This has stimulated interest in the preventive potential of a...... antioxidant supplements. Today, more than one half of adults in high-income countries ingest antioxidant supplements hoping to improve their health, oppose unhealthy behaviors, and counteract the ravages of aging....

  5. Realidad de la cirugía cardíaca en la República Argentina. Registro CONAREC XVI

    Diego M. Lowenstein Haber

    2010-01-01

    Full Text Available RESUMENIntroducciónLos dos grandes registros multicéntricos de cirugía cardíaca realizados en la Argentina,CONAREC y ESMUCICA, datan de más de 10 años. Considerando los avances médicosy quirúrgicos de la última década, surgió la necesidad de realizar un nuevo registronacional, prospectivo y multicéntrico para conocer las características, la evolución, lascomplicaciones y los predictores de mortalidad de los pacientes sometidos a cirugía cardíaca.ObjetivosConocer el perfil epidemiológico, la modalidad quirúrgica y la evolución posoperatoria de lospacientes sometidos a cirugía cardíaca en la Argentina.Material y métodosRegistro prospectivo, consecutivo y multicéntrico realizado en 49 centros cardioquirúrgicosde la República Argentina por residentes de cardiología. Se analizaron las características yla evolución de 2.553 pacientes sometidos a cirugía cardíaca entre septiembre de 2007 yoctubre de 2008: 1.465 (57,4% a cirugía coronaria, 359 (14,1% a reemplazo valvular aórtico,169 (6,6% a cirugía valvular mitral, 312 (12,2% a cirugía combinada coronariovalvular y248 (9,7% a otros procedimientos.ResultadosHubo predominio de hombres (74,9%; la edad promedio fue de 63 ± 11 años. La prevalenciade diabetes fue del 24,9%, la de hipertensión del 76,3% y la de insuficiencia cardíaca del17%. La disfunción ventricular moderada a grave prequirúrgica fue del 23,8% y el 19,8% delas cirugías fueron no programadas.En las cirugías coronarias, el 41,9% de ellas se realizaron sin circulación extracorpórea y seempleó puente mamario en el 89%.El 81,7% de las cirugías mitrales se indicaron por insuficiencia y el 62,6% de las aórticas,por estenosis. En estas cirugías se emplearon válvulas mecánicas en el 58% de los casos.La mediana de internación fue de 6 días. Se presentaron complicaciones mayores en el31,7% (del 25% en coronarios al 49,36% en combinados y la mortalidad global fue del 7,7%(del 4,3% en coronarios al 13

  6. Avaliação do sensor de contratilidade cardíaca em sistema DDDR: estudo multicêntrico

    ANDRADE José Carlos S.

    1998-01-01

    Full Text Available Introdução: O tratamento de distúrbios na condução atrioventricular associados a doenças do nó sinusal com o emprego de marcapassos DDDR tem incentivado a procura de um sensor ideal. Objetivo: Avaliar a resposta de freqüência do marcapasso com sensor de contratilidade em situações de esforço físico e mental, tanto em laboratório como em atividades diárias de pacientes com bradicardia e insuficiência cronotrópica. Casuística e Métodos: Do estudo multicêntrico brasileiro "Projeto Inos DR _ Brasil", que emprega um sistema de estimulação DDDR cujo indicador é o estado contrátil do miocárdio, foram selecionados 38 pacientes com insuficiência cronotrópica, sendo 21 do sexo masculino e 17 do sexo feminino, com idades variando de 13 a 83 anos (média de 57 anos. O marcapasso utiliza um parâmetro do próprio controle cardiovascular (contratilidade cardíaca obtida pela medida da impedância cardíaca unipolar para a adaptação da freqüência cardíaca, num sistema de malha fechada que, teoricamente, possibilita um ajuste a todas as necessidades fisiológicas. A calibração e programação do sistema só foi realizada 30 dias após o implante (tempo de maturação da irterface coração-eletrodo, realizando-se, então, teste de estresse mental (matemático e teste ergométrico (em esteira, monitorados com histograma de freqüência e com curvas de consumo de oxigênio. Resultados: A média de limiares agudos de estimulação foi de 0,82 Volts e 0,55 Volts, e a média de limiares de sensibilidade foi de 2,37 mV e 10,61 mV, respectivamente, para átrios e ventrículos. A média de limiares crônicos de estimulação foi de 1,44 Volts e 1,18 Volts, e a média de limiares de sensibilidade foi de 2,81 mV e 6,3 mV, respectivamente para átrios e ventrículos. A freqüência cardíaca variou de 5% a 128% nas atividades físicas e de 5% a 80% nas atividades mentais, com elevação logo no início das atividades, permitindo uma curva

  7. Active components in food supplements

    Siemelink M; Jansen EHJM; Piersma AH; Opperhuizen A; LEO

    2000-01-01

    The growing food supplement market, where supplements are both more diverse and more easily available (e.g. through Internet) formed the backdrop to the inventory of the active components in food supplements. The safety of an increased intake of food components via supplements was also at issue her

  8. El sildenafil mejora la capacidad de ejercicio en pacientes con insuficiencia cardíaca crónica

    Clemente H. Magallanes

    2010-01-01

    Full Text Available AntecedentesLos agentes inhibidores de la fosfodiesterasa 5, como el sildenafil, son vasodilatadores moderados ampliamente utilizados para el tratamiento de la disfunción eréctil. En la actualidad, la evidencia disponible establece su potencial aplicación en otras patologías, como la hipertensión pulmonar, la disfunción endotelial y la insuficiencia cardíaca crónica. ObjetivoEl presente estudio fue diseñado para comprobar si la administración de sildenafil en pacientes con insuficiencia cardíaca crónica en clase funcional II-III mejora la capacidad de ejercicio en comparación con placebo.Material y métodosSe seleccionaron en forma aleatoria 70 pacientes portadores de insuficiencia cardíaca crónica de cualquier etiología, excepto valvulares, todos con tratamiento óptimo. Para su inclusión en el estudio, los pacientes debían tener un diámetro diastólico ventricular izquierdo > 55 mm, una fracción de eyección 90 mm Hg. Se excluyeron los que se encontraban anémicos, aquellos con indicación de cirugía por cualquiercausa o los que por diversos motivos no pudieran realizar una caminata de seis minutos. Luego de una caminata de seis minutos fueron aleatorizados para recibir 50 mg de sildenafil o placebo, conformándose dos grupos, placebo y sildenafil, ambos con 35 participantes. Luego de 1 hora de la ingestión de las drogas se realizó una nueva caminata de seis minutos. Antes y después de cada caminata se controlaron las siguientes variables: presión arterial sistólica, diastólica y frecuencia cardíaca; se registraron también los metros caminados en cada prueba.ResultadosCaracterísticas generales, grupo placebo versus grupo sildenafil: hombres: 74% vs 88%, etiología isquémico-necrótica: 71% vs 77%, clase funcional II: 37% vs 34%, clase funcional III: 63% vs 66%, edad: 68 ± 10 vs 68 ± 12 años, fracción de eyección: 26,5% ± 7,8% vs 26,5% ± 6,5%, diámetro diastólico ventricular izquierdo: 65 ± 6 vs 66 ± 9

  9. Análisis comportamental aplicado (ACA) y trastornos generalizados del desarrollo (TGD): su evaluación en Argentina

    María de los Angeles Matos; Alba Elisabeth Mustaca

    2005-01-01

    Se presentan los resultados obtenidos con la intervención basada en Análisis Comportamental Aplicado (ACA) o manejo de contingencias, en 9 niños (8 varones y 1 mujer) de 2 a 5 años con Trastornos Generalizados del Desarrollo (TGD). Este tratamiento basado en métodos desarrollados por Lovaas y colaboradores (1981) fue implementado en una institución argentina especializada. Se evaluaron las siguientes áreas: comprensión del lenguaje, funciones del comportamiento, nivel ...

  10. Insuficiência renal aguda em pacientes internados por insuficiência cardíaca descompensada - Reincade

    Larissa Cristina Nascimento de Barros; Fábio Serra Silveira; Marcos Serra Silveira; Thamara Carvalho Morais; Marco Antônio Prado Nunes; Kleyton de Andrade Bastos

    2012-01-01

    INTRODUÇÃO: Insuficiência renal aguda (IRA) acontece com frequência em pacientes críticos, porém a significância clínica de sua ocorrência não tem sido determinada na insuficiência cardíaca descompensada (ICD). OBJETIVOS: Estudar a ocorrência e valor prognóstico da IRA em pacientes internados por ICD e avaliar comparativamente com aqueles sem a complicação o perfil clínico-laboratorial e a mortalidade intra-hospitalar. MÉTODOS: Estudo prospectivo em 85 pacientes internados em terapia intensiv...

  11. Controle microbiológico em valvas cardíacas humanas Microbiologyc control in human heart valves

    Angela Maria Peruzzo; Francisco Diniz Affonso da Costa; Wanda Moscalewski Abrahão

    2006-01-01

    OBJETIVO: Avaliar, sob o aspecto microbiológico, valvas processadas pelo Banco de Valvas Cardíacas Humanas da Irmandade da Santa Casa de Misericórdia de Curitiba, para serem utilizadas em cirurgias cardiovasculares. MÉTODOS: Foi avaliado o processamento de 1.671 valvas, no período de junho de 1999 a junho de 2004. Das valvas e soluções envolvidas no processo foram coletadas amostras e semeadas nos meios de cultura: meio líquido tioglicolato, caldo soja tripticaseína e caldo Sabouraud, com qua...

  12. Optical properties of $A$Fe$_\\mathbf{2}$As$_\\mathbf{2}$ ($A=\\,$Ca, Sr, and Ba) single crystals

    Dai, Y. M.; Akrap, A.; Bud'ko, S. L.; Canfield, P. C.; Homes, C. C.

    2016-01-01

    The detailed optical properties have been determined for the iron-based materials $A$Fe$_2$As$_2$, where $A=\\,$Ca, Sr, and Ba, for light polarized in the iron-arsenic ($a-b$) planes over a wide frequency range, above and below the magnetic and structural transitions at $T_N =\\,$138, 195, and 172~K, respectively. The real and imaginary parts of the complex conductivity are fit simultaneously using two Drude terms in combination with a series of oscillators. Above $T_N$, the free-carrier respon...

  13. Efeitos da Effleurage de diferentes pressões na função cardíaca

    Moreira, Nídia Maria Gomes

    2014-01-01

    Objectivo: Determinar os efeitos da effleurage de diferentes pressões na função cardíaca. Metodologia: Foram seleccionadas 30 pessoas com as idades compreendidas entre os 20 a 25 anos todos do género masculino e sem patologias. Estes jovens foram divididos aleatoriamente em três grupos: grupo controlo (GC) (N=10), grupo effleurage superficial (GES) (N=10) e grupo effleurage profunda (GEP) (N=10). Foi utilizado um metrónomo para monitorizar a respiração, tendo sido utilizado um polar e um esfi...

  14. Supplement use by Young Athletes

    Jill Anne McDowall

    2007-01-01

    This paper reviews studies of supplement use among child and adolescent athletes, focusing on prevalence and type of supplement use, as well as gender comparisons. Supplement use among adult athletes has been well documented however there are a limited number of studies investigating supplement use by child and adolescent athletes. A trend in the current literature revealed that the most frequently used supplements are in the form of vitamin and minerals. While health and illness prevention a...

  15. Perfil clínico y funcional de los pacientes con insuficiencia cardíaca sistólica y disfunción renal

    ADRIANA ACOSTA; MÁXIMO MIGLIORI; NORA VAINSTEIN; JAVIER C. MARINO; RAMIRO GUGLIELMONE; MARCELO S. TRIVI; MÓNICA SULTÁN; FERNANDO BRITES; JORGE M. THIERER

    2009-01-01

    RESUMENIntroducciónLa disfunción renal está fuertemente asociada con la insuficiencia cardíaca crónica. Es unacomplicación habitual y progresiva de esta condición, con una evolución clínica que fluctúacon la clase funcional y el tratamiento farmacológico.ObjetivosDefinir la prevalencia y el perfil clínico y funcional de pacientes con disfunción renal en elcontexto de insuficiencia cardíaca con baja fracción de eyección.Material y métodosEn 132 pacientes con insuficiencia cardíaca y fracción d...

  16. Cèl·lules mare mesenquimals humanes: aïllament, caracterització i potencialitat per a la regeneració cardíaca

    Farré Crespo, Jordi

    2008-01-01

    La insuficiència cardíaca congestiva és una epidèmia creixent a nivell mundial. Les causes principals de la insuficiència cardíaca estan relacionades amb el dany irreversible que resulta d'un infart de miocardi. El cor humà té una capacitat de regeneració limitada, i la pèrdua de múscul, juntament amb la contracció i la fibrosi de la cicatriu miocàrdica, posen en joc un conjunt d'esdeveniments anomenats remodelat ventricular, que finalment tendeixen cap a una insuficiència cardíaca congestiva...

  17. Aneurisma de artéria ilíaca interna roto: relato de caso Ruptured internal iliac artery aneurysm: case report

    Cristina Toledo Afonso; Ricardo Jayme Procópio; Túlio Pinho Navarro; Gustavo Henrique Dumont Kleinsorge; Beatriz Deoti e Silva Rodrigues; Marco Antônio Gonçalves Rodrigues

    2009-01-01

    Aneurismas isolados da artéria ilíaca interna são raros, acometem 0,1% da população e correspondem a 1% dos aneurismas aorto-ilíacos. Na maioria das vezes, os pacientes são assintomáticos, mas podem apresentar dor abdominal, massa pulsátil no hipogástrio ou na fossa ilíaca, sintomas compressivos urinários, gastrointestinais ou neurológicos. Podem ocasionar quadro de abdome agudo, principalmente quando há ruptura. O diagnóstico precoce dos aneurismas isolados de artéria ilíaca interna é incomu...

  18. Comparação de critérios diagnósticos de insuficiência renal aguda em cirurgia cardíaca

    2013-01-01

    FUNDAMENTO: Há grande controvérsia quanto ao diagnóstico de Insuficiência Renal Aguda (IRA), existindo mais de 30 diferentes definições. OBJETIVO: Avaliar a incidência e os fatores de risco para desenvolvimento de IRA no pós-operatório de cirurgia cardíaca de acordo com os critérios RIFLE, AKIN e KDIGO, e comparar o poder prognóstico desses critérios. MÉTODOS: Estudo de corte transversal que incluiu 321 pacientes (62 [53 - 71] anos, 140 homens) consecutivamente submetidos a cirurgia cardíaca ...

  19. Prevalência de doença celíaca em crianças e adolescentes com miocardite e cardiomiopatia dilatada

    Thaysa Maria Gama Albuquerque Leão de Menezes

    2012-10-01

    Full Text Available OBJETIVO: Determinar a prevalência de doença celíaca em pacientes portadores de cardiomiopatia dilatada e miocardite. MÉTODOS: Foram avaliados 56 pacientes, com idade entre 1 e 18 anos, portadores de cardiomiopatia dilatada ou miocardite, acompanhados no Instituto Materno Infantil Professor Fernando Figueira. Foram excluídos pacientes com diagnóstico prévio de doença celíaca. A classe funcional da insuficiência cardíaca foi determinada segundo os critérios da American Heart Association, como classe funcional I, II, III e IV. O diagnóstico de miocardite foi relatado em prontuário, e o de cardiomiopatia dilatada, pelo ecocardiograma, a partir da presença de disfunção sistólica de um ou ambos os ventrículos, com fração de ejeção menor que 55% e dilatação ventricular, com diâmetro diastólico final ventricular esquerdo maior que 112%. Nos pacientes incluídos no estudo, foi aplicado um formulário com informações sobre sintomatologia gastrointestinal e cardiológica; em seguida, dosadas sorologias para anticorpos antitransglutaminase tecidual humana e antiendomísio. Aqueles com sorologia positiva foram encaminhados à biópsia intestinal para avaliação histológica para doença celíaca, segundo os critérios de Marsh. RESULTADOS: Uma das 56 crianças apresentou sorologia antitransglutaminase positiva (1,8%, porém anticorpo antiendomísio negativo. A histologia intestinal demonstrou atrofia total das vilosidades. Cerca de 30% dos pacientes apresentaram insuficiência cardíaca. Sinais e sintomas gastrointestinais foram frequentes nos pacientes, em especial dor abdominal (70%, 39/56. CONCLUSÃO: A frequência de doença celíaca em pacientes com cardiomiopatia dilatada e miocardite foi de 1,8%. É importante investigar doença celíaca nos pacientes com essas doenças cardíacas para evitar evolução das doenças e deterioração clínica do paciente.

  20. Variabilidad de la frecuencia cardíaca en individuos sanos costarricenses

    Oswaldo Gutiérrez Sotelo

    2000-04-01

    Full Text Available Introducción. El análisis de la variabilidad de la frecuencia cardíaca (VFC, refleja la influencia autonómica sobre el corazón pudiendo ser predictivo de mortalidad. Consiste en el análisis de las variaciones de los intervalos RR. Este estudio analizó la VFC en individuos sanos costarricenses. Materiales y Métodos. Fueron elegidos adultos asintomáticos. En la adquisición de datos se utilizó una derivación electrocardiográfica estándar y se calcularon variables tanto en Dominio de Tiempo como en Dominio de Frecuencia. Se compararon los resultados desde registros de 5 minutos y de 10 minutos y se compararon diferentes grupos etáreos dividiéndose a la población en grupos: 18 a 29 años, 30 a 39 y 40 y también entre Introduction. Heart rate variability analysis evaluate the autonomic influence over the heart and therefore, is a predictive tool of mortality. It consists in the analysis of the variations in RR intervals. This study assessed heart rate variability in healthy costarrican people. Materials and Methods. We included adult healthy volunteers. For data adquisition we used a single electrocardiographic lead and calculate time and frequency domain variables. We compared results between 5 minutes versus 10 minutes samples and between age groups: 18 to 29 years old, versus 30 to 39 versus 40 or < 25 years old versus 25. Results. We studied 48 subjects, 25 women and 23 men (range 18 y 53. We do not obtained differences between time of data adquisition samples but find differences between 18-29 vs 40 and <25 vs 25 age groups in NN50 (231.432 vs 34.500, p = 0.004 in the fisrt group, 237.250 vs 53.250, p<0.001, the second, %NN50 (30.732 vs 5.2, p=0.003 and 31.444 vs 9.742, p=0.001 respectively, LF (457.338 vs 173.393, p=0.045 and 466.816 vs 259.361, p=0.042 respectively and HF (750.667 vs 239.865, p=0.068 and 766.834 vs 248.436, p=0.010 respectively. Conclusions. This study support reference values for comparision or to individual

  1. Evidence Suggests That The ACA's Tobacco Surcharges Reduced Insurance Take-Up And Did Not Increase Smoking Cessation.

    Friedman, Abigail S; Schpero, William L; Busch, Susan H

    2016-07-01

    To account for tobacco users' excess health care costs and encourage cessation, the Affordable Care Act (ACA) allowed insurers to impose a surcharge on tobacco users' premiums for plans offered on the health insurance exchanges, or Marketplaces. Low-income tax credits for Marketplace coverage were based on premiums for non-tobacco users, which means that these credits did not offset any surcharge costs. Thus, this policy greatly increased out-of-pocket premiums for many tobacco users. Using data for 2011-14 from the Behavioral Risk Factor Surveillance System, we examined the effect of tobacco surcharges on insurance status and smoking cessation in the first year of the exchanges' implementation, among adults most likely to purchase insurance from them. Relative to smokers who faced no surcharges, smokers facing medium or high surcharges had significantly reduced coverage (reductions of 4.3 percentage points and 11.6 percentage points, respectively), but no significant differences in smoking cessation. In contrast, those facing low surcharges showed significantly less smoking cessation. Taken together, these findings suggest that tobacco surcharges conflicted with a major goal of the ACA-increased financial protection-without increasing smoking cessation. States should consider these potential effects when deciding whether to limit surcharges to less than the federal maximum. PMID:27385231

  2. Layout Design of Human-Machine Interaction Interface of Cabin Based on Cognitive Ergonomics and GA-ACA

    Li Deng

    2016-01-01

    Full Text Available In order to consider the psychological cognitive characteristics affecting operating comfort and realize the automatic layout design, cognitive ergonomics and GA-ACA (genetic algorithm and ant colony algorithm were introduced into the layout design of human-machine interaction interface. First, from the perspective of cognitive psychology, according to the information processing process, the cognitive model of human-machine interaction interface was established. Then, the human cognitive characteristics were analyzed, and the layout principles of human-machine interaction interface were summarized as the constraints in layout design. Again, the expression form of fitness function, pheromone, and heuristic information for the layout optimization of cabin was studied. The layout design model of human-machine interaction interface was established based on GA-ACA. At last, a layout design system was developed based on this model. For validation, the human-machine interaction interface layout design of drilling rig control room was taken as an example, and the optimization result showed the feasibility and effectiveness of the proposed method.

  3. Factors Affecting Health Insurance Enrollment Through the State Marketplaces: Observations on the ACA's Third Open Enrollment Period.

    Giovannelli, Justin; Curran, Emily

    2016-07-01

    Issue: Nearly 12.7 million individuals signed up for coverage in the Affordable Care Act's (ACA) health insurance marketplaces during the third open enrollment period, and by the end of March there were 11.1 million consumers with active coverage. States that operate their own marketplaces posted a year-to-year enrollment gain of 8.8 percent. To maintain membership and attract new consumers, the state-based marketplaces must sponsor enrollment assistance programs and conduct consumer outreach. These marketplaces relied heavily on such efforts during the third enrollment period, despite declining funding. Goal: To learn which outreach strategies, assistance programs, and other factors marketplace officials viewed as having exerted the greatest influence on enrollment. Methods: Survey of officials representing each of the 17 state-based marketplaces (15 responses). Key findings and conclusions: The cost of coverage and low health insurance literacy pose significant barriers to enrollment for many consumers. Marketplaces sought to overcome them by encouraging consumers to obtain in-person enrollment assistance from ACA-created assistance programs and from insurance brokers, and by partnering with community organizations for outreach activities. Many marketplaces also enhanced their web portals to make them easier to navigate and to give consumers better tools with which to evaluate their coverage options. PMID:27459742

  4. Layout Design of Human-Machine Interaction Interface of Cabin Based on Cognitive Ergonomics and GA-ACA.

    Deng, Li; Wang, Guohua; Yu, Suihuai

    2016-01-01

    In order to consider the psychological cognitive characteristics affecting operating comfort and realize the automatic layout design, cognitive ergonomics and GA-ACA (genetic algorithm and ant colony algorithm) were introduced into the layout design of human-machine interaction interface. First, from the perspective of cognitive psychology, according to the information processing process, the cognitive model of human-machine interaction interface was established. Then, the human cognitive characteristics were analyzed, and the layout principles of human-machine interaction interface were summarized as the constraints in layout design. Again, the expression form of fitness function, pheromone, and heuristic information for the layout optimization of cabin was studied. The layout design model of human-machine interaction interface was established based on GA-ACA. At last, a layout design system was developed based on this model. For validation, the human-machine interaction interface layout design of drilling rig control room was taken as an example, and the optimization result showed the feasibility and effectiveness of the proposed method. PMID:26884745

  5. Ergogenic Aids and Supplements.

    Porrini, Marisa; Del Boʼ, Cristian

    2016-01-01

    Great interest is currently shown for the contribution of nutrition to optimize training and athletic performance, and a considerable debate exists about the potential ergogenic value of several dietary supplements. However, most of the products used by athletes do not provide sufficient scientific evidence regarding their efficacy in enhancing physical performance as well as their specificity of action and safety. For this reason, sport nutrition professionals need skills in evaluating the scientific value of papers and advertisements on ergogenic aids and supplements in order to support athletes in their choice. In the present chapter, the efficacy of some of the most popular supplements used by athletes and sport practitioners will be discussed. Particular attention will be devoted to amino acids and derivatives, caffeine and caffeinated energy drinks, and some antioxidants. PMID:27348226

  6. Determinants of dietary supplement use - healthy individuals use dietary supplements

    Kofoed, Christina L F; Christensen, Jane; Dragsted, Lars Ove;

    2015-01-01

    The prevalence of dietary supplement use varies largely among populations, and previous studies have indicated that it is high in the Danish population compared with other European countries. The diversity in supplement use across countries indicates that cultural and environmental factors could...... influence the use of dietary supplements. Only few studies investigating the use of dietary supplements have been conducted in the Danish population. The present cross-sectional study is based on 54 948 Danes, aged 50-64 years, who completed self-administrated questionnaires on diet, dietary supplements and...... intake of dietary supplements. We found that 71 % of the participants were dietary supplement users; female sex, older age groups and higher educated participants were more likely to be users of any dietary supplements. One additional point in the health index was associated with 19, 16 and 9 % higher...

  7. Psychology: Teacher Supplement.

    Stark, Rebecca

    This supplement provides teachers with tests, quizzes, answers to questions in the text, and general teaching information for using the student text, "Psychology," by Rebecca Stark. Quizzes included are on the topics of human development; the nervous system; the brain; cognitive development; sensation and perception; conditioning; learning;…

  8. Supplemental TV Taped Problems.

    Squires, Robert G.; Frank, David V.

    1983-01-01

    Videotapes were developed as supplemental material for a course in chemical engineering thermodynamics. Describes the course, videotapes produced (includes list by topics as related to course content), and effectiveness of the tapes. Although no significant improvement in test performance was noted, students indicated they learned material faster…

  9. Oral Supplementation of Myoinositol

    Gregersen, G.; Bertelsen, B.; Harbo, H.;

    1983-01-01

    28 young diabetics with short disease duration participated in a double-blind study by taking 6 g of myoinositol or placebo daily for 2 months. The aim was to demonstrate a possible beneficial effect of this compound on subclinical diabetic neuropathy. Measurement of vibratory perception threshol...... of myoinositol in their muscle tissue remained uninfluenced by oral supplementation of myoinositol....

  10. Dietary Supplements: What Is Safe?

    ... articles window. My Saved Articles » My ACS » Dietary Supplements: What Is Safe? Download Printable Version [PDF] » Dietary supplements include things like vitamins, minerals, herbs, or products ...

  11. Vitamin Supplements: Healthy or Hoax?

    ... Recognition & Awards Healthy Workplace Food and Beverage Toolkit Vitamin Supplements: Healthy or Hoax? Updated:Jun 12,2015 Can vitamin and mineral supplements really make you healthier? Overwhelmed ...

  12. Weight Loss Nutritional Supplements

    Eckerson, Joan M.

    Obesity has reached what may be considered epidemic proportions in the United States, not only for adults but for children. Because of the medical implications and health care costs associated with obesity, as well as the negative social and psychological impacts, many individuals turn to nonprescription nutritional weight loss supplements hoping for a quick fix, and the weight loss industry has responded by offering a variety of products that generates billions of dollars each year in sales. Most nutritional weight loss supplements are purported to work by increasing energy expenditure, modulating carbohydrate or fat metabolism, increasing satiety, inducing diuresis, or blocking fat absorption. To review the literally hundreds of nutritional weight loss supplements available on the market today is well beyond the scope of this chapter. Therefore, several of the most commonly used supplements were selected for critical review, and practical recommendations are provided based on the findings of well controlled, randomized clinical trials that examined their efficacy. In most cases, the nutritional supplements reviewed either elicited no meaningful effect or resulted in changes in body weight and composition that are similar to what occurs through a restricted diet and exercise program. Although there is some evidence to suggest that herbal forms of ephedrine, such as ma huang, combined with caffeine or caffeine and aspirin (i.e., ECA stack) is effective for inducing moderate weight loss in overweight adults, because of the recent ban on ephedra manufacturers must now use ephedra-free ingredients, such as bitter orange, which do not appear to be as effective. The dietary fiber, glucomannan, also appears to hold some promise as a possible treatment for weight loss, but other related forms of dietary fiber, including guar gum and psyllium, are ineffective.

  13. Abbott radiative energy attenuation method for quantifying ethanol evaluated and compared with gas-liquid chromatography and the Du Pont aca.

    Cary, P L; Whitter, P D; Johnson, C A

    1984-11-01

    Quantification of ethanol by a radiative energy attenuation (REA) technique was evaluated and compared with results by gas-liquid chromatography (GLC) and by the Du Pont aca. Within-assay CVs were less than 5.5%. Between-assay CVs ranged from 1.9% to 6.0% for serum and blood controls at concentrations of 0.5, 1.0, and 2.5 g/L. We observed no cross reactivity with methanol, isopropanol, or acetone, and analytical recovery of ethanol from serum averaged 101%. For the three-method comparison we performed parallel determinations of 156 blood, 92 serum, and 54 urine samples containing a wide range of ethanol concentrations. Linear regression analysis of the REA results vs those of GLC or aca yielded the following: for serum, REA = 1.03 GLC -0.03 (r = 0.998), REA = 1.13 aca -0.04 (r = 0.999); for blood, REA = 0.97 GLC + 0.05 (r = 0.994), REA = 0.99 aca + 0.06 (r = 0.996); and for urine, REA = 1.01 GLC -0.03 (r = 0.998). We also discuss the clinical and forensic use of the REA method for ethanol. PMID:6386230

  14. Há evidências favorecendo o uso de betabloqueadores e dobutamina na insuficiência cardíaca aguda?

    Luiz Carlos Santana Passos

    2013-02-01

    Full Text Available Diversos estudos relataram os benefícios dos betabloqueadores (BB para pacientes com insuficiência cardíaca sistólica. No entanto, muitos pacientes hospitalizados em decorrência de insuficiência cardíaca aguda já estão usando os BB e requerem dobutaminas para hipotensão arterial e baixo débito cardíaco. Portanto, deve-se tomar uma decisão a respeito de se o BB deve ser mantido ou até mesmo iniciado nesses casos. O objetivo deste estudo foi determinar se há provas que sustentem a segurança e a eficácia dos BB junto com a dobutamina para pacientes com insuficiência cardíaca aguda descompensada (ICAD. Foi realizada uma pesquisa na literatura de língua inglesa nas bases de dados MEDLINE, ISI Web of Science, Biblioteca Virtual em Saúde, Cochrane Library e o Portal de Revistas Científicas do Capes para identificar estudos relacionados. Literatura adicional foi obtida mediante a análise das respectivas referências encontradas nos artigos identificados. Os resultados esperados incluíram informações sobre o prognóstico (intra-hospitalar e na mortalidade no acompanhamento, número de dias de internação e reinternação, eficácia e segurança (agravamento dos sintomas, choque, intolerância do uso concomitante desses medicamentos em pacientes hospitalizados com ICAD e baixo débito cardíaco. Esta análise incluiu nove estudos. No entanto, não foram encontrados ensaios clínicos randomizados sobre o assunto. A maioria dos estudos inclui baixo número de pacientes, e não foram encontrados estudos que abordem a segurança do uso concomitante desses medicamentos. Os dados resultantes sugerem que uma cuidadosa revisão da literatura não forneceu evidências para o uso sistemático de BB em pacientes com síndrome de baixo débito cardíaco que necessitam de suporte inotrópico com dobutamina.

  15. Avaliação por ressonância magnética de massas cardíacas

    Maria Fernanda Braggion-Santos

    2013-09-01

    Full Text Available FUNDAMENTO: Tumores cardíacos são extremamente raros; no entanto, quando há suspeita clínica, é necessária a correta avaliação diagnóstica, para planejar o tratamento mais adequado. Nesse contexto, a ressonância magnética cardiovascular tem um papel importante, permitindo uma abrangente caracterização de tais lesões. OBJETIVO: Revisar os casos encaminhados a um Serviço de Ressonância Magnética para investigação de massas cardíacas e paracardíacas. Descrever a série de casos positivos, juntamente de uma breve revisão da literatura para cada tipo de lesão e sobre o papel da ressonância magnética cardiovascular em sua avaliação. MÉTODOS: Entre agosto de 2008 e dezembro de 2011, foram revistos todos os casos de pacientes encaminhados a ressonância magnética com suspeita de neoplasia envolvendo o coração. Foram selecionados aqueles com confirmação histopatológica, evolução ou resposta terapêutica compatíveis com a suspeita clínica e achados de imagem. RESULTADOS: Entre os 13 pacientes incluídos neste estudo, oito (62% tiveram confirmação histopatológica. Foram descritas cinco neoplasias benignas (mixomas, rabdomioma e fibromas, cinco neoplasias malignas (sarcoma, linfoma, síndrome de Richter cardíaca e doença metastática e três lesões não neoplásicas (cisto pericárdico, trombo intracardíaco e vegetação infecciosa. CONCLUSÃO: A informação disponível sobre essa questão é escassa. Estudos prospectivos adicionais são necessários para elucidar o papel desses nutrientes no risco cardiovascular de pacientes com diabetes.

  16. Vitamin and Mineral Supplement Fact Sheets

    ... Tables Online DRI Tool Daily Value (DV) Tables Vitamin and Mineral Supplement Fact Sheets Search the list ... Supplements: Background Information Botanical Dietary Supplements: Background Information Vitamin and Mineral Fact Sheets Botanical Supplement Fact Sheets ...

  17. Variabilidade da frequência cardíaca em neonatos prematuros e de termo Variabilidad de la frecuencia cardíaca en neonatos prematuros y de término Heart rate variability in preterm and term neonates

    Fabio Augusto Selig

    2011-06-01

    Full Text Available FUNDAMENTO: Várias publicações têm demonstrado a importância do sistema nervoso autônomo por meio dos componentes simpático e parassimpático na gerência da interação entre as diferentes partes do organismo humano. Esses estudos aplicaram técnicas lineares e não lineares (Teoria do Caos de avaliação em diferentes situações, doenças e faixas etárias, tendo como ferramenta a variabilidade da frequência cardíaca (VFC. OBJETIVO: Aplicar os conhecimentos das dinâmicas linear e não linear na avaliação de neonatos prematuros (NPT, analisando sua VFC e comparando com neonatos de termo (NT saudáveis. MÉTODOS: Quarenta e oito neonatos prematuros com diferentes idades gestacionais tiveram seus batimentos cardíacos captados com auxílio do equipamento Polar Advanced S810i e sua VFC obtida pelo registro dos intervalos RR. A VFC foi analisada nos domínios do tempo (SDNN, RMSSD, SD1/SD2, da frequência (VLF, LF, HF e a relação LF/HF e do caos (TAU e sua normalização [TAU(n], Expoente de Lyapunov e Entropia. Os NPT foram comparados com um grupo de 78 NT saudáveis e sem intercorrências perinatais com auxílio do teste não paramétrico de Kruskal-Wallis. RESULTADOS: Detectou-se diferença estatisticamente significante entre os grupos para todas as variáveis estudadas, tanto no domínio do tempo como nos da frequência e do caos. CONCLUSÃO: Neonatos prematuros exibem comportamento menos complexo da variabilidade da frequência cardíaca que neonatos de termo, fato comprovado nos domínios do tempo, da frequência e do caos. O estudo da variabilidade cardíaca nesse grupo pode ser considerado uma ferramenta a mais na avaliação da maturação autonômica e, consequentemente, da progressão para eutrofia.FUNDAMENTO: Varias publicaciones han demostrado la importancia del sistema nervioso autónomo por medio de los componentes simpático y parasimpático en el manejo de la interacción entre las diferentes partes del organismo

  18. Incidência de cirurgia cardíaca em octogenários: estudo retrospectivo Incidencia de cirugía cardíaca en octogenarios: estudio retrospectivo Incidence of cardiac surgery in octogenarian patients: retrospective study

    Luciano Brandão Machado

    2003-09-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O aumento da expectativa de vida faz com que pacientes cada vez mais idosos tenham indicação de tratamento cirúrgico de cardiopatias. Este estudo tem como objetivo avaliar a incidência de pacientes com mais de 80 anos submetidos à cirurgia cardíaca no Instituto do Coração do Hospital das Clínicas da FMUSP, nos últimos 16 anos. MÉTODO: Foram analisados, no período de 1986 a 2001, o número de cirurgias de revascularização do miocárdio (RM e cirurgia valvar (CV e, em cada grupo, o número de cirurgias em pacientes com mais de 80 anos. Os dados foram analisados descritivamente. RESULTADOS: Os dados revelam aumento progressivo do número de octogenários submetidos à cirurgia cardíaca. As cirurgias de revascularização do miocárdio tiveram aumento de 0,13% em 1986 para 3,5% em 2001. As cirurgias valvares aumentaram de 0% em 1986 para 1,44% em 2001, registrando o maior valor de 3,02% em 1999. CONCLUSÕES: Os conhecimentos da fisiopatologia, da senilidade e os avanços no manuseio do trauma cirúrgico estão permitindo estender os recursos da cirurgia cardíaca no grupo de paciente mais idoso. A escolhas da técnica anestésica deve ser criteriosa, bem como a hidratação, a assistência ventilatória e a analgesia pós-operatória, permitindo redução da morbimortalidade neste grupo de maior risco cirúrgico.JUSTIFICATIVA Y OBJETIVOS: El aumento de la expectativa de vida hace con que pacientes cada vez mas edosos tengan indicación de tratamiento quirúrgico de cardiopatias. Este estudio tiene como objetivo evaluar la incidencia de pacientes con más de 80 años sometidos a cirugía cardíaca en el Instituto del Corazón del Hospital de Clínicas de la FMUSP, en los últimos 16 años. MÉTODO: Fueron analizados, en el período de 1986 a 2001, el número de cirugías de revascularización del miocardio (RM y cirugía valvar (CV y, en cada grupo, el número de cirugías en pacientes con más de 80 a

  19. O trabalho da enfermagem no pós-operatório de cirurgia cardíaca: uma revisão integrativa

    Ana Paula Azevedo Santos

    2015-05-01

    Full Text Available Este estudo teve o objetivo de identificar, por meio de produções científicas nacionais e internacionais, os cuidados desenvolvidos pela equipe de enfermagem durante a assistência ao paciente no pósoperatório de cirurgia cardíaca. Trata-se de uma revisão integrativa realizada por meio de busca às bases PubMed, LILACS, CINAHL, SCOPUS e BDENF no período de fevereiro a junho de 2014, com o seguinte questionamento: “Quais os cuidados realizados pela equipe de enfermagem ao paciente no pós-operatório de cirurgia cardíaca?” Utilizou-se como critério de inclusão artigos científicos publicados nos últimos cinco anos, em português, inglês e espanhol, disponíveis na íntegra. Foram selecionados 21 artigos e, mediante a sua leitura criteriosa, foi realizada análise descritiva, possibilitando o agrupamento dos dados em um núcleo temático: cuidando do paciente no pós-operatório de cirurgia cardíaca, que apontou subcategorias: assistindo o paciente após cirurgia cardíaca, gerenciando a dor e a comunicação como ferramenta no cuidado de enfermagem. Os cuidados desenvolvidos no pós-operatório de cirurgia cardíaca demonstram a necessidade de organização do processo de trabalho da equipe de enfermagem bem como competências específicas dos profissionais para atuarem nesse cenário, com intuito de promover um cuidado individualizado e qualificado.

  20. Neuronal counting and parasympathetic dysfunction in the hearts of chronically Trypanosoma cruzi - infected rats Contagem neuronal e disfunção cardíaca parassimpática em ratos cronicamente infectados pelo Trypanosoma cruzi

    E. Chapadeiro

    1991-10-01

    Full Text Available Ten male Wistar rats, chronically infected with Colombian, São Felipe (12SF and Y strains of Trypanosoma cruzi and ten non-infected control animals were submitted to the bradycardia responsiveness test, an assessment of heart parasympathetic function, after phenylephrine injection. Six chagasic animals showed heart parasympathetic dysfuntion characterized by reduction in the index of bradycardia baroreflex responsiveness, as compared with the control group. Microscopic examination of the atrial heart ganglia of chagasic rats showed ganglionitis, but no statiscally significant reduction in the number of neurons.Dez ratos machos Wistar cronicamente infectados pelas cepas Colombiana, São Felipe (12SF, e Y do Trypanosoma cruzi, foram submetidos, após 8 meses de infecção, juntamente com dez animais controles, ao teste da resposta bradicárdica barorreflexa pela injeção endovenosa de fenilefrina. Seis ratos chagásicos exibiram disfunção cardíaca parassimpática, caracterizada pela depressão do índice da resposta bradicárdica barorreflexa. Embora o estudo histológico dos corações chagásicos mostrasse lesões dos gânglios atriais, a contagem dos neurônios em cortes seriados, não apresentou redução numérica significativa dos mesmos.

  1. Suporte ventilatório na capacidade funcional de pacientes com insuficiência cardíaca: estudo piloto

    Eugênia da Silva Lima

    2011-03-01

    Full Text Available FUNDAMENTO: A insuficiência cardíaca é um importante problema de saúde pública, apresentando a dispneia e a fadiga como principais sintomas clínicos. A utilização do suporte ventilatório não invasivo vem atuando como coadjuvante da reabilitação cardíaca na tentativa de melhorar a capacidade funcional dos pacientes. OBJETIVO: Avaliar a capacidade funcional de pacientes com insuficiência cardíaca submetidos ao suporte ventilatório. MÉTODOS: Foram avaliados dados sociodemográficos, qualidade de vida, FC, pressão arterial (PA, saturação periférica de oxigênio (SpO2, dispneia, concentração de lactato, antes e depois do teste de caminhada de 6 minutos, e a distância percorrida de pacientes com insuficiência cardíaca crônica (ICC, de ambos os sexos, com fração FEVE < 45,0%, randomizados em dois grupos: controle e CPAP (utilizou CPAP 10 cmH2O por 30 minutos. RESULTADOS: Participaram 12 pacientes com ICC classe funcional II e III (NYHA, com média de fração de ejeção do ventrículo esquerdo (FEVE, % de 35,3 ± 8,7, sendo que 8 eram do sexo masculino. A média de idade foi de 46,3 ± 10,3 anos. Na comparação entre os grupos Controle e CPAP, no final do 6º min, foi encontrada diferença significativa nos valores de SpO2% entre os grupos (Controle: 93,6 ± 1,5 % vs CPAP: 96,1 ± 1,8%; p = 0,027, dispneia (Controle: 13,1 ± 1,16 vs CPAP: 11 ± 0,8; p = 0,009, concentração de lactato (Controle: 3,3 ± 0,7 mmol/l vs CPAP: 2,3 ± 0,5 mmol/l; p = 0,025, e distância percorrida no TC6 (Controle: 420,6 ± 73,8 m vs CPAP: 534 ± 89,91 m; p = 0,038. CONCLUSÃO: A realização prévia do CPAP apresentou efeitos benéficos na SpO2, na dispneia, na concentração de lactato, no duplo produto e na distância percorrida no TC6 de pacientes com ICC na realização do TC6.

  2. Patologia cardíaca: novos biomarcadores associados ao diagnóstico e prognóstico

    Matias, António Pedro Laranjo

    2012-01-01

    Dissertação de mest., Ciências Farmacêuticas, Faculdade de Ciências e Tecnologia, Univ. do Algarve, 2012 As patologias cardíacas afetam cada vez mais indivíduos em todo o mundo, sendo uma das principais causas de debilitação e morte. Podem ter um caráter crónico ou agudo, sendo essencial uma eficaz deteção e acompanhamento da evolução das mesmas. Com este trabalho de revisão bibliográfica pretende-se mostrar a utilidade de substâncias participantes de processos fisiológicos endógenos co...

  3. Os benefícios do recrutamento alveolar nos doentes submetidos a cirurgia cardíaca

    Frias, Ana; Rodrigues, Liliana; Pavia, Patrícia

    2012-01-01

    As complicações pulmonares resultantes da anestesia, trauma cirúrgico e circulação extracorpórea são muito frequentes em doentes submetidos a cirurgia cardíaca, sendo a atelectasia e a hipoxia duas das complicações mais comuns. A atuação do enfermeiro especialista de reabilitação assume um papel preponderante na execução de técnicas para melhorar a mecânica respiratória e reexpansão pulmonar, sendo a mais utilizada a manobra de recrutamento alveolar. Objetivo: conhecer os benefícios do recrut...

  4. [ERGOGENIC SPORT SUPPLEMENTS FOR ATHLETES].

    Arieli, Rakefet; Lahav, Yair

    2016-06-01

    Use of performance-enhancing supplements occurs at all levels of sports, from recreational athletes to professional athletes. Although some supplements do enhance athletic performance, many have no proven benefits and have adverse effects. Nutritional supplements are categorized into the following categories: I. Apparently Effective. II. Possibly Effective. III. Too Early To Tell. IV. Apparently Ineffective. This article will review 4 ergogenic supplements which are categorized in the first category--"Apparently Effective"--1) Buffer agents 2) Creatine 3) Caffeine and 4 Nitric Oxide. Given the widespread use of performance enhancing supplements, physicians, and dietitians should be prepared to counsel athletes about their effectiveness, safety and legality. PMID:27544991

  5. Effective Nutritional Supplement Combinations

    Cooke, Matt; Cribb, Paul J.

    Few supplement combinations that are marketed to athletes are supported by scientific evidence of their effectiveness. Quite often, under the rigor of scientific investigation, the patented combination fails to provide any greater benefit than a group given the active (generic) ingredient. The focus of this chapter is supplement combinations and dosing strategies that are effective at promoting an acute physiological response that may improve/enhance exercise performance or influence chronic adaptations desired from training. In recent years, there has been a particular focus on two nutritional ergogenic aids—creatine monohydrate and protein/amino acids—in combination with specific nutrients in an effort to augment or add to their already established independent ergogenic effects. These combinations and others are discussed in this chapter.

  6. Resveratrol food supplements

    Aschemann-Witzel, Jessica; Grunert, Klaus G

    2015-01-01

    comparing US and Danish respondents, we aimed to identify whether sociodemographic variables, health status, health beliefs and behaviour and interest in food aspects specifically relevant to resveratrol (e.g., naturalness, indulgence, and Mediterranean food) explain favourable attitudes and adoption...... intentions toward resveratrol supplements. Methods: A survey sent to a representative online panel in the United States and Denmark was analysed using linear regression. Results: We find that sociodemographic variables contribute little to explaining favourable attitudes toward and adoption intentions of...... intention. An interest in the indulgence dimension of food explains positive attitudes in the United States and adoption intentions in both countries. Conclusions: The results indicate that potential consumers of resveratrol supplements are identified by their usage of complementary and alternative medicine...

  7. Food Components and Supplements

    Parlesak, Alexandr

    2012-01-01

    The major part of food consists of chemical compounds that can be used for energy production, biological synthesis, or maintenance of metabolic processes by the host. These components are defined as nutrients, and can be categorized into macronutrients (proteins, carbohydrates, triglycerides, and...... alcohol), minerals, and micronutrients. The latter category comprises 13 vitamins and a hand full of trace elements. Many micronutrients are used as food supplements and are ingested at doses exceeding the amounts that can be consumed along with food by a factor of 10–100. Both macro- and micronutrients...... supplements and contaminants can compete directly with drug oxidation, induce or suppress the expression of xenobiotic-metabolizing enzymes, change the bioavailability of drugs, and, in the case of live bacteria, bring in their own xenobiotic metabolism, including cytochrome P450 (CYP) activity. In numerous...

  8. Anticorpos séricos na doença celíaca Celiac disease serum antibodies

    Ceres Concilio ROMALDINI

    1999-12-01

    Full Text Available O diagnóstico acurado da doença celíaca é muito importante porque os pacientes devem aderir a uma dieta sem glúten por toda a vida e diante do maior risco de complicações, como as neoplasias intestinais, que poderá advir do não cumprimento rigoroso da dieta. Nesta revisão são apresentados os novos conceitos referentes às formas de apresentação da doença (ativa, silenciosa, latente e potencial e sua associação com outras enfermidades e são focalizados principalmente o valor e a eficácia da determinação dos anticorpos séricos antigliadina e dos autoanticorpos anti-reticulina, antiendomísio e antitransglutaminase tecidual, no auxílio ao diagnóstico e seguimento da doença celíaca.Accurate diagnosis of celiac disease is important because patients are advised to adhere to a strict gluten-free diet for life. This management is critical to avoid disease complications such as malignancies. In this review the new terminology for the disease clinical features (active, silent, latent and potential celiac disease and the disease association with other conditions are commented. The value and efficacy of the assessment of serum antigliadin antibodies and of antireticulin, antiendomysial and tissue transglutaminase autoantibodies in the diagnosis and follow-up of the celiac disease are particularly evaluated.

  9. Electronic structure and photocatalytic properties of ABi2Ta2O9 (A=Ca, Sr, Ba)

    A new series of layered perovskite photocatalysts, ABi2Ta2O9 (A=Ca, Sr, Ba), were synthesized by the conventional solid-state reaction method and the crystal structures were characterized by powder X-ray diffraction. The results showed that the structure of ABi2Ta2O9 (A=Ca, Sr) is orthorhombic, while that of BaBi2Ta2O9 is tetragonal. First-principles calculations of the electronic band structures and density of states (DOS) revealed that the conduction bands of these photocatalysts are mainly attributable to the Ta 5d+Bi 6p+O 2p orbitals, while their valence bands are composed of hybridization with O 2p+Ta 5d+Bi 6s orbitals. Photocatalytic activities for water splitting were investigated under UV light irradiation and indicated that these photocatalysts are highly active even without co-catalysts. The formation rate of H2 evolution from an aqueous methanol solution is about 2.26 mmol h-1 for the photocatalyst SrBi2Ta2O9, which is much higher than that of CaBi2Ta2O9 and BaBi2Ta2O9. The photocatalytic properties are discussed in close connection with the crystal structure and the electronic structure in details. - Graphical abstract: The valence band of the photocatalysts is consisted of O 2p, Ta 5d and Bi 6s orbitals and the conduction band is from Bi 6p, Ta 5d and O 2p orbitals. Photocatalytic properties of the photocatalyst for H2 evolution without using other co-catalysts from CH3OH/H2O solution and O2 evolution from AgNO3/H2O solution were observed under Hg lamp irradiation

  10. Ansiedade no período pré-operatório de cirurgia cardíaca

    Karyne Kirley Negromonte Gonçalves

    2016-04-01

    Full Text Available RESUMO Objetivo: caracterizar a ansiedade dos pacientes no pré-operatório de cirurgia cardíaca. Método: Foi realizado um estudo de corte transversal no qual 106 pacientes, entre um e cinco dias da data da cirurgia, foram entrevistados utilizando-se um questionário sócio-demográfico próprio e o Inventário de Ansiedade de Beck. Resultados: Os pacientes avaliados se apresentaram em 59,4% (63 na ansiedade mínima e 19,8% (21 na faixa considerada grave, tendo a amostra uma média no nível de ansiedade leve (15,8±19,79. As mulheres tiveram escores (22,13±23,41 significativamente (p=0,003 maiores que os homens (10,76±14,71; assim como os pacientes que já haviam sido submetidos a cirurgia cardíaca prévia (24,4±28,05 X 13,14±15,74. Não houve diferença significativa entre idosos e pacientes adultos mais jovens, nem no tocante as variações de peso, presença de diabetes ou etilismo. Conclusão: Reforça-se a importância do enfermeiro reconhecer a ansiedade pré-operatória e intervir através de estratégias de educação em saúde e visita de enfermagem.

  11. Valor preditivo da frequência cardíaca em repouso do teste ergométrico na mortalidade

    Jaqueline Eilert Fagundes

    2010-12-01

    Full Text Available FUNDAMENTO: A frequência cardíaca em repouso (cuja média está entre 60 e 80 bpm é uma das mais simples variáveis cardiovasculares e tem sido considerada como um preditor de mortalidade cardiovascular e geral. OBJETIVO: Avaliar o valor preditivo da frequência cardíaca em repouso (FCR, antes do teste ergométrico (TE, na mortalidade cardiovascular (CV e geral. MÉTODOS: Estudo de caso-controle, que utilizou informações contidas nos bancos de dados do laboratório de ergometria de um hospital especializado em cardiologia e os registros de óbitos da Secretaria da Saúde em uma cidade do sul do Brasil, de janeiro de 1995 a junho de 2007. Foram analisados 7.055 pacientes, sendo 1.645 (23,3% do grupo caso (óbitos e 5.410 (76,7% do grupo controle (vivos. Foi calculado o ponto de corte da FCR para mortalidade, através da curva ROC e realizada a análise multivariada para as variáveis selecionadas. Os desfechos foram mortalidade CV e geral. RESULTADOS: A incidência de mortalidade CV foi de 674 casos (9,5%; a FCR > 78 bpm foi o ponto de corte. Após ajustado para as variáveis selecionadas, o odds ratio (OR para FCR > 78 bpm foi de 3,5 (IC 95% = 2,9 - 4,2 para mortalidade CV e 3,6 (IC 95% = 3,2 - 4,0 para mortalidade geral. CONCLUSÃO: A FCR > 78 bpm é um preditor independente de mortalidade cardiovascular e geral.

  12. Relação entre imagem adrenérgica cardíaca e teste ergométrico na insuficiência cardíaca Relación entre imagen adrenérgica cardíaca y ergometría en la insuficiencia cardíaca Relationship between cardiac adrenergic image and exercise testing in heart failure

    Leandro Rocha Messias

    2011-05-01

    Full Text Available FUNDAMENTO: Na insuficiência cardíaca, o teste ergométrico (TE avalia capacidade funcional, um determinante de prognóstico. A cintilografia com I¹²³ MIBG mostra a ativação simpática cardíaca. OBJETIVO: Avaliar a associação entre as variáveis do TE e as alterações da cintilografia com I¹²³ MIBG. MÉTODOS: Foram submetidos 23 pacientes (FEVE 27%. Esses pacientes realizaram TE, onde foram analisadas: pressão arterial sistólica no pico do esforço (PASP, frequência cardíaca no pico do esforço (FCP, variação da pressão arterial sistólica intraesforço (Δ PAS, reserva cronotrópica e capacidade funcional em METs. Utilizaram-se para a análise estatística, o teste t de Student ou o teste U de Mann-Whitney, o coeficiente de Spearman e o coeficiente de regressão linear. RESULTADOS: A PASP (G1: 181,00 ± 28,01; G2: 153,27 ± 27,71, p = 0,027, a Δ PAS [G1: 64 (47,5-80,5; G2: 36 (25-47 mmHg, p = 0,015], a FCP (G1: 136,91 ± 19,66; G2: 118,45 ± 13,98 bpm, p = 0,018, a reserva cronotrópica (G1: 70,42 ± 17,94; G2: 49,47 ± 14,89%, p = 0,006 e a capacidade funcional [G1: 8,37 (6,47-10,27; G2: 4,42 (2,46-6,38 METs, p = 0,003] foram menores no G2. Houve correlação negativa entre taxa de Washout com PASP (r = -0,505, p = 0,014, Δ PAS (r = -0,493, p = 0,017 e capacidade funcional (r = -0,646, p = 0,001. Após regressão linear, PASP (r = -0,422, p = 0,016 e capacidade funcional (r = -0,804, p = 0,004 foram associadas com taxa de Washout. CONCLUSÃO: Em pacientes com insuficiência cardíaca, PASP e capacidade funcional foram as varáveis mais associadas com a taxa de Washout.FUNDAMENTOS: En la Insuficiencia Cardíaca, la Ergometría (Test Ergométrico - TE evalúa la capacidad funcional, un determinante de pronóstico. El centellograma con I¹²³ MIBG muestra la activación simpática cardíaca. OBJETIVO: Evaluar la asociación entre las variables del TE y las alteraciones del centellograma con I¹²³ MIBG. MÉTODOS: Se

  13. The financial burden of medical spending: estimates and implications for evaluating the impact of ACA reforms.

    Abramowitz, Joelle; O'Hara, Brett

    2015-04-01

    This article uses the 2013 Current Population Survey Annual Social and Economic Supplement to estimate the financial burden of medical out-of-pocket costs by comparing medical out-of-pocket expenditures to income. This measure is important for evaluating the magnitude of burden, better understanding who bears it, and establishing a baseline to assess the impact of the Patient Protection and Affordable Care Act. We examine the distribution of burden and the incidence of high burden across all families and by individuals' health insurance status and demographic and socioeconomic characteristics. We look more closely at one group vulnerable to having high burden: those younger than age 65 with incomes between 138% and 200% of the federal poverty line. We find that 18.5% of these individuals have incomes below the threshold of expansion Medicaid eligibility after accounting for non-over-the-counter medical expenses and examine the characteristics associated with being classified below this threshold. PMID:25524865

  14. Perfil epidemiológico, clínico e terapêutico da insuficiência cardíaca em hospital terciário Perfil epidemiológico, clínico y terapéutico de la insuficiencia cardíaca en hospital terciario Epidemiological, clinical e therapeutic profile of heart failure in a tertiary hospital

    Patrícia Resende Nogueira; Salvador Rassi; Krislainy de Sousa Corrêa

    2010-01-01

    FUNDAMENTO: A insuficiência cardíaca é uma síndrome complexa com múltiplos fatores de risco envolvidos em sua gênese, tornando difícil a prevenção e o manejo. OBJETIVO: Identificar as principais etiologias e os fatores de risco na insuficiência cardíaca; comparar características clínicas e demográficas dos pacientes conforme a etiologia; analisar se o tratamento utilizado está de acordo com o preconizado pelas diretrizes brasileiras. MÉTODOS: Estudo retrospectivo, descritivo e observacional r...

  15. Growth capacity of thermotolerant campylobacters in culture media supplemented with pig and cow blood

    Álvaro Tresierra-Ayala; Manuel Navas; Josué Flores; Ramsés Perea; Juan Huanaquiri; María Bendayán; Heriberto Fernández

    2010-01-01

    In this work 60 thermotolerant Campylobacter strains (37 C. jejuni and 23 C. coli) isolated from the cows, pigs, chickens and ducks (15 strains of each type of animal) were used to establish their growth capacity on media containing cow or swine blood as potential substitutes of sheep or horse blood. The growth capacity was assessed by viable counts on cow and swine blood media, using the modified Miles and Misra method. Campylobacter strains showed better growth in the media supplemented wit...

  16. Miniesternotomia: um acesso seguro para a cirurgia cardíaca

    Leonardo Andrade MULINARI

    1997-10-01

    Full Text Available Atualmente, na constante busca de minimizar o tempo de intemação hospitalar e melhorar a recuperação no pós-operatório, várias altemativas cirúrgicas têm sido aventadas. Iniciamos o uso da estemotomia parcial como acesso para diversos tipos de operações cardíacas. O presente trabalho tem como objetivo apresentar a evolução hospitalar dos pacientes operados através desta técnica. No período de novembro de 1996 a março de 1997, estudamos 51 pacientes operados através da esternotomia parcial. A idade média foi de 46,8 anos, sendo 26 pacientes do sexo feminino. Os procedimentos mais realizados foram o tratamento cirúrgico valvar e as revascularizações miocárdicas. O acesso utilizado para os pacientes com lesões valvares foi a esternotomia parcial em "T" invertido no segmento superior do esterno; para outras lesões, uma esternotomia em "T" no segmento inferior e, pela dificuldade técnica imposta nas re-operações e nos procedimentos múltiplos, utilizou-se uma terceira variação, que foi a esternotomia parcial em "H" deitado, estendendo-se no corpo esternal do primeiro ao quarto espaço intercostal. O comprimento médio da incisão de pele foi de 9,9 cm. Foram realizadas 19 incisões em "T", 17 em "T" invertido e 15 em "H" deitado. O tempo médio de ventilação mecânica foi de 2,8 horas, de permanência na UTI de 31,5 horas e de internação hospitalar de 5,9 dias. Não houve complicação diretamente relacionada com o acesso e em apenas 1 caso foi necessária a conversão para a esternotomia total. Analisando a evolução destes 51 pacientes, pudemos concluir que a esternotomia parcial é um acesso seguro para o tratamento cirúrgico de diversas cardiopatias, isoladas, associadas ou re-operações. Traz um resultado estético favorável e facilita a recuperação no pós- operatório, devendo fazer parte do repertório de todo o cirurgião cardiovascular.Recently, in the constant search for shortening hospital stay and

  17. Construção e Validação do Questionário de Conhecimentos para Pacientes com Insuficiência Cardíaca

    Christiani Decker Batista Bonin

    2014-04-01

    Full Text Available Fundamento: A ausência de instrumentos capazes de mensurar o nível de conhecimento de pacientes com insuficiência cardíaca sobre sua própria síndrome, participantes de programas de reabilitação, demonstra a carência de recomendações específicas a respeito da quantidade ou do conteúdo de informações necessárias. Objetivo: Construir e validar um questionário para avaliar o conhecimento sobre sua condição de pacientes portadores de insuficiência cardíaca participantes de programas de reabilitação cardíaca. Métodos: O instrumento foi construído com base no questionário de conhecimento para doença coronariana e aplicado em 96 pacientes com insuficiência cardíaca, com média de idade de 60,22 ± 11,6 anos, 64% homens. A reprodutibilidade foi obtida por meio do coeficiente de correlação intraclasse, utilizando-se as situações do método de teste-reteste. A consistência interna foi obtida pelo alfa de Cronbach e a validade do construto, pela análise fatorial exploratória. Resultados: A versão final do instrumento apresentou 19 questões dispostas em dez áreas de importância para a educação do paciente. O instrumento proposto apresentou um índice de clareza de 8,94 ± 0,83. O valor do coeficiente de correlação intraclasse foi de 0,856 e do alfa de Cronbach, 0,749. A análise fatorial revelou cinco fatores associados às áreas de conhecimento. Quando os escores finais foram comparados com as características da população, verificou-se que baixa escolaridade e baixa renda estão significativamente associadas a baixos escores de conhecimento. Conclusão: O instrumento possui índice de clareza satisfatório e de validade adequado, podendo ser utilizado para avaliar o conhecimento de pacientes com insuficiência cardíaca participantes de programas de reabilitação cardíaca.

  18. Limiar ventilatório e variabilidade da freqüência cardíaca em adolescentes Umbral ventilatorio y variabilidad de la frecuencia cardíaca en los adolescentes Ventilatory threshold and heart rate variability in adolescents

    Antônio Fernando Brunetto

    2005-02-01

    Full Text Available As análises da concentração sanguínea de lactato e das trocas gasosas respiratórias são métodos tradicionalmente empregados para identificar a transição de produção de energia pelo metabolismo muscular. No entanto, mais recentemente, vem sendo sugerido método alternativo mediante análise da variabilidade da freqüência cardíaca. Pretendeu-se, com o presente estudo, estabelecer comparações entre o limiar de variabilidade da freqüência cardíaca (LiVFC e o primeiro limiar ventilatório (LV1, em uma amostra de adolescentes. Para tanto, foram submetidos a teste de esforço físico de carga máxima em esteira ergométrica 41 sujeitos (22 rapazes e 19 moças com idades entre 15 e 18 anos. O LV1 foi identificado mediante o equivalente ventilatório de oxigênio envolvendo recursos de ergoespirometria. A variabilidade da freqüência cardíaca foi analisada por intermédio dos intervalos R-R, através da plotagem de Poincaré, que oferece informações quanto ao desvio-padrão da variabilidade instantânea batimento-a-batimento (SD1, ao desvio-padrão a longo prazo de intervalos R-R contínuos (SD2 e à razão SD1/SD2. O LiVFC foi identificado pelo SD1 de acordo com três critérios: (1 diferenças entre o SD1 de dois estágios consecutivos menor que 1ms; (2 SD1 menor que 3ms; e (3 ocorrência de ambos os critérios em conjunto. Mediante análise dos resultados verificou-se que os intervalos R-R e SD2 diminuíram progressivamente a cada intervalo de 10% do VO2pico até o final do teste de esforço físico (0,05 El análisis de la concentración sanguínea de lactato y de los cambios gaseosos respiratorios son métodos tradicionalmente empleados para identificar la transición de la producción de energía por el metabolismo muscular. No en tanto, mas recientemente viene siendo sugerido como método alternativo mediante el análisis de la variabilidad de la frecuencia cardíaca. Se pretende con el presente estudio establecer

  19. Frequência Cardíaca de Recuperação no Primeiro Minuto no Teste de Caminhada de Seis Minutos em Pacientes com Insuficiência Cardíaca

    Sabrina Lindemberg

    2014-03-01

    Full Text Available Fundamento: A frequência cardíaca de recuperação no primeiro minuto (FCR1 é um preditor de mortalidade na insuficiência cardíaca (IC, mas seu prognóstico não foi avaliado no teste de caminhada de seis minutos (TC6M nesses pacientes. Objetivo: Esse estudo teve como objetivo determinar a FCR1 no TC6M em pacientes com IC e sua correlação com a distância percorrida em seis minutos (DP6M. Métodos: Protocolo controlado, transversal, com 161 indivíduos, 126 pacientes com IC sistólica estável, divididos em dois grupos (G1 e G2, que receberam ou não β-bloqueador e 35 voluntários no grupo controle (G3 que tiveram a FCR1 registrada no TC6M. Resultados: A FCR1 e a DP6M foram significativamente diferentes nos três grupos. Os valores médios de FCR1 e DP6M foram: FCR1 = 12 ± 14 bpm G1, 18 ± 16 bpm G2 e 21 ± 13 bpm G3; DP6M = 423 ± 102 m G1, G2 396 ± 101 m e 484 ± 96 m G3 (p < 0,05. Os resultados demonstraram uma correlação entre FCR1 e DP6M no G1 (r = 0,3, p = 0,04 e G3 (r = 0,4, p = 0,03, mas não em G2 (r = 0,12, p = 0,48. Conclusão: A resposta da FCR1 foi atenuada em pacientes em uso de βB e mostrou correlação com o TC6M, refletindo uma melhor tolerância ao exercício. A FCR1 após a DP6M parece representar uma alternativa quando os testes de esforço na esteira não são tolerados.

  20. Bodybuilding supplementation and tooth decay.

    Ali, M S; Batley, H; Ahmed, F

    2015-07-10

    Supplementation is a key component in bodybuilding and is increasingly being used by amateur weight lifters and enthusiasts to build their ideal bodies. Bodybuilding supplements are advertised to provide nutrients needed to help optimise muscle building but they can contain high amounts of sugar. Supplement users are consuming these products, while not being aware of their high sugar content, putting them at a higher risk of developing dental caries. It is important for dental professionals to recognise the increased risk for supplement users and to raise awareness, provide appropriate preventative advice and be knowledgeable of alternative products to help bodybuilders reach their goals, without increasing the risk of dental caries. PMID:26159983

  1. Geobacteraceae strains and methods

    Lovley, Derek R.; Nevin, Kelly P.; Yi, Hana

    2015-07-07

    Embodiments of the present invention provide a method of producing genetically modified strains of electricigenic microbes that are specifically adapted for the production of electrical current in microbial fuel cells, as well as strains produced by such methods and fuel cells using such strains. In preferred embodiments, the present invention provides genetically modified strains of Geobacter sulfurreducens and methods of using such strains.

  2. Optimización de un modelo de soporte para bioprótesis valvular cardíaca mediante métodos numéricos

    Diego Marín

    2001-04-01

    Full Text Available Las bioprótesis valvulares cardíacas (BVC son sometidas a diferentes
    requerimientos mecánicos para cumplir con la actividad hemodinámica cardíaca. La experiencia demuestra que el soporte de
    la bioprótesis (ASBVC ejerce un importante papel en la operatividad
    del implante, relacionado con la distribución de tensiones en las valvas biológicas y la adecuada coaptación. Para evaluar el comportamiento del ASBVC es necesario analizar los esfuerzos y tensión necesarios para alcanzar la fatiga del dispositivo, así como calcular la concentración esfuerzo-deformación durante su funcionamiento.

  3. Estetoscópio digital como ferramenta inovadora no ensino da ausculta cardíaca Digital stethoscope as an innovative tool on the teaching of auscultatory skills

    Claudio Tinoco Mesquita; Jader Costa dos Reis; Luciana Silveira Simões; Eduardo Cardoso de Moura; Gustavo Amarante Rodrigues; Carolina Cunto de Athayde; Hugo Lima Machado; Pedro Gemal Lanzieri

    2013-01-01

    O exame físico cardiovascular, em particular a ausculta cardíaca, é uma das habilidades clínicas mais difíceis para os alunos durante seu treinamento médico. Estudos sugerem que o uso de tecnologias, como o estetoscópio digital, aumente a acurácia do exame clínico, entretanto, seu impacto no ensino da propedêutica da ausculta cardíaca em alunos de graduação de Medicina não é conhecido. O objetivo é demonstrar a utilidade do estetoscópio digital, em comparação com métodos tradicionais, como in...

  4. El aumento del riesgo de mortalidad en la cirugía cardíaca. ¿Realmente estamos operando pacientes con incremento del riesgo?

    Raúl A. Borracci; Miguel Rubio

    2006-01-01

    Aunque varios estudios parecen demostrar el aumento en el tiempo del riesgo quirúrgico de los candidatos a cirugía cardíaca, la mayoría de las comunicaciones se basan en su incremento promedio, sin analizar la verdadera distribución por grupos de riesgo. Con el objetivo de evaluar si en la actualidad existe un aumento del riesgo de mortalidad en la cirugía cardíaca en nuestro medio respecto del riesgo de una década atrás, basándonos no sólo en la variación promedio, sino también en la dis...

  5. Importancia de la cirugía aorto-ilíaca previa o simultánea en la evolución del trasplante renal

    Martínez Carnovale, Lucía Inés

    2011-01-01

    La malaltia renal crònica terminal, el tractament substitutiu d'elecció és el trasplantament renal, és un problema de salut pública mundial en augment. L'envelliment de la població i la major prevalença de diabetis i hipertensió arterial en aquests pacients, s'associa a una major incidència de malaltia aorto-ilíaca i possible fracàs del ronyó trasplantat. En aquest treball es va analitzar l'evolució del filtrat glomerular en pacients trasplantats renals amb patologia aorto-ilíaca que van requ...

  6. Dosagem única de troponina cardíaca T prediz risco adverso na insuficiência cardíaca descompensada Dosificación única de troponina cardíaca T predice riesgo adverso en la insuficiencia cardiaca descompensada Single cardiac troponin T measurement predicts risk for adverse outcome in decompensated heart failure

    Manoel D. C. Oliveira

    2010-04-01

    Full Text Available FUNDAMENTO: O aumento discreto de troponina cardíaca no sangue de pacientes com insuficiência cardíaca (IC sugere que miofibrilas são degradadas no miocárdio e liberadas na circulação, refletindo um processo contínuo e progressivo de lesão do aparato contrátil. OBJETIVO: Correlacionar o nível sérico da troponina cardíaca-T (TnTc à admissão hospitalar de pacientes com IC descompensada e o prognóstico. MÉTODOS: Foram incluídos 79 pacientes consecutivos, internados por IC descompensada, com FEVE 2,5 mg%, insuficiência hepática ou doenças neuromusculares. RESULTADOS: Detectou-se TnTc elevada (>0,02 ng/ml em 37 pacientes (46,84%. A mortalidade global foi de 35,4%. Nos grupos TnTc elevada e TnTc baixa (FUNDAMENTO: El aumento discreto de troponina cardíaca en la sangre de pacientes con insuficiencia cardiaca (IC sugiere que miofibrillas se degraden en el miocardio y se liberen en la circulación, lo que refleja un proceso continuo y progresivo de lesión del aparato contráctil. OBJETIVO: Correlacionar el nivel sérico de la troponina cardíaca-T (TnTc al ingreso hospitalario de pacientes con IC descompensada y el pronóstico. MÉTODOS: Se incluyó a 79 pacientes consecutivos, internados por IC descompensada, con FEVI 2,5 mg%, insuficiencia hepática o enfermedades neuromusculares. RESULTADOS: Se detectó TnTc elevada (> 0,02 ng/ml en 37 pacientes (46,84%. La mortalidad global fue del 35,4%. En los grupos TnTc elevada y TnTc baja (BACKGROUND: The slight increase in cardiac troponin in the blood of patients with heart failure (HF suggests that myofibrils are degraded in the myocardium and released in the circulation, reflecting a continuous and progressive injury process in the contractile system. OBJECTIVE: To correlate the serum levels of cardiac troponin T (TnT at the hospital admission of patients with decompensated HF and prognosis. METHODS: A total of 79 consecutive patients, hospitalized due to decompensated HF, with LVEF 2

  7. Tissue-specific root ion profiling reveals essential roles of the CAX and ACA calcium transport systems in response to hypoxia in Arabidopsis.

    Wang, Feifei; Chen, Zhong-Hua; Liu, Xiaohui; Colmer, Timothy David; Zhou, Meixue; Shabala, Sergey

    2016-06-01

    Waterlogging is a major abiotic stress that limits the growth of plants. The crucial role of Ca(2+) as a second messenger in response to abiotic and biotic stimuli has been widely recognized in plants. However, the physiological and molecular mechanisms of Ca(2+) distribution within specific cell types in different root zones under hypoxia is poorly understood. In this work, whole-plant physiological and tissue-specific Ca(2+) changes were studied using several ACA (Ca(2+)-ATPase) and CAX (Ca(2+)/proton exchanger) knock-out Arabidopsis mutants subjected to waterlogging treatment. In the wild-type (WT) plants, several days of hypoxia decreased the expression of ACA8, CAX4, and CAX11 by 33% and 50% compared with the control. The hypoxic treatment also resulted in an up to 11-fold tissue-dependent increase in Ca(2+) accumulation in root tissues as revealed by confocal microscopy. The increase was much higher in stelar cells in the mature zone of Arabidopsis mutants with loss of function for ACA8, ACA11, CAX4, and CAX11 In addition, a significantly increased Ca(2+) concentration was found in the cytosol of stelar cells in the mature zone after hypoxic treatment. Three weeks of waterlogging resulted in dramatic loss of shoot biomass in cax11 plants (67% loss in shoot dry weight), while in the WT and other transport mutants this decline was only 14-22%. These results were also consistent with a decline in leaf chlorophyll fluorescence (F v/F m). It is suggested that CAX11 plays a key role in maintaining cytosolic Ca(2+) homeostasis and/or signalling in root cells under hypoxic conditions. PMID:26889007

  8. MicroRNAs: um novo paradigma no tratamento e diagnóstico da insuficiência cardíaca?

    Vagner Oliveira-Carvalho

    2012-04-01

    Full Text Available MicroRNAs (miRNAs são um grupo recém-descoberto de pequenos RNAs, não codificantes, que representam uma das áreas mais estimulantes da ciência médica moderna por modularem uma enorme e complexa rede regulatória da expressão dos genes.Recentemente, linhas de evidências sugerem que os miRNAs desempenham um papel crucial na patogênese da insuficiência cardíaca. Alguns miRNAs altamente expressos no coração como o miR-1, miR-133 e miR-208 estão fortemente associados ao desenvolvimento da hipertrofia cardíaca, enquanto o exato papel de miR-21 no sistema cardiovascular permanece controverso. Os níveis séricos de miRNAs circulantes como o miR-423-5p estão sendo avaliados como potenciais biomarcadores no diagnóstico e prognóstico da insuficiência cardíaca.Por outro lado, a manipulação dos níveis de miRNAs usando técnicas como os mimetizadores de miRNAs (miRmimics e miRNAs antagônicos(antagomiRs está tornando cada vez mais evidente o enorme potencial dos miRNAs como promissoras estratégias terapêutica sna insuficiência cardíaca.

  9. Plate-forme Magicien d'Oz pour l'\\'etude de l'apport des ACAs \\`a l'interaction

    Simonin, Jérôme; Hategan, Marius; Carbonell, Noëlle

    2007-01-01

    In order to evaluate the contribution of Embodied (Animated) Conversational Agents (ECAs) to the effectiveness and usability of human-computer interaction, we developed a software platform meant to collect usage data. This platform, which implements the wizard of Oz paradigm, makes it possible to simulate user interfaces integrating ACAs for any Windows software application. It can also save and "replay" a rich interaction trace including user and system events, screen captures, users' speech...

  10. Mead production: selection and characterization assays of Saccharomyces cerevisiae strains.

    Pereira, Ana Paula; Dias, Teresa; Andrade, João; Ramalhosa, Elsa; Estevinho, Letícia M

    2009-08-01

    Mead is a traditional drink, which results from the alcoholic fermentation of diluted honey carried out by yeasts. However, when it is produced in a homemade way, mead producers find several problems, namely, the lack of uniformity in the final product, delayed and arrested fermentations, and the production of "off-flavours" by the yeasts. These problems are usually associated with the inability of yeast strains to respond and adapt to unfavourable and stressful growth conditions. The main objectives of this work were to evaluate the capacity of Saccharomyces cerevisiae strains, isolated from honey of the Trás-os-Montes (Northeast Portugal), to produce mead. Five strains from honey, as well as one laboratory strain and one commercial wine strain, were evaluated in terms of their fermentation performance under ethanol, sulphur dioxide and osmotic stress. All the strains showed similar behaviour in these conditions. Two yeasts strains isolated from honey and the commercial wine strain were further tested for mead production, using two different honey (a dark and a light honey), enriched with two supplements (one commercial and one developed by the research team), as fermentation media. The results obtained in this work show that S. cerevisiae strains isolated from honey, are appropriate for mead production. However it is of extreme importance to take into account the characteristics of the honey, and supplements used in the fermentation medium formulation, in order to achieve the best results in mead production. PMID:19481129

  11. Avaliação eletrofisiológica cardíaca em pacientes com sarcoidose

    Jefferson Curimbaba

    2011-04-01

    Full Text Available FUNDAMENTO: Sarcoidose é uma doença granulomatosa multissistêmica de origem desconhecida que pode causar morte súbita. OBJETIVO: Avaliação eletrofisiológica de pacientes com sarcoidose com suspeita de comprometimento cardíaco. MÉTODOS: Foram estudados 22 pacientes com média de idade de 55,32 ±13,13 anos, com diagnóstico de sarcoidose e suspeita de comprometimento cardíaco. Foram submetidos à avaliação clínica, exames laboratoriais, eletrocardiograma, ecocardiograma, Holter de 24h, cintilografia com gálio ou tecnécio e estudo eletrofisiológico. Em casos selecionados foi realizada tomografia por emissão de pósitrons ou ressonância magnética. Os pacientes foram seguidos ambulatoriamente com consultas trimestrais. RESULTADOS: Comprometimento cardíaco foi comprovado em quatro (18,2% pacientes. Extrassístoles ventriculares com densidade > 100/24h foram documentadas no Holter de 24h em 12 (54,5 % pacientes. O estudo eletrofisiológico revelou aumento do intervalo HV em sete (31,8% e ponto de Wenckebach aumentado em quatro (18,2% pacientes. Houve indução de fibrilação atrial em sete (31,8% e de taquicardia ventricular sustentada em um (4,5%. Nos quatro pacientes com sarcoidose cardíaca confirmada, extrassístoles ventriculares, com densidade > 100/24h foram documentadas em todos, dois apresentavam intervalo HV prolongado e fibrilação atrial foi induzida em dois. Taquicardia ventricular sustentada não foi induzida em nenhum desses pacientes. Após período médio de acompanhamento de 20,9 ± 15,7 meses, um paciente com sarcoidose cardíaca apresentou morte súbita. CONCLUSÃO: Pacientes com sarcoidose e suspeita de envolvimento cardíaco apresentam alta prevalência de EVs e distúrbios do sistema de condução.

  12. Recomendações da sociedade brasileira de arritmias cardíacas para serviços de holter

    Adalberto Lorga Filho

    2013-08-01

    Full Text Available FUNDAMENTOS: Inúmeros indicadores são utilizados para assegurar a qualidade de um serviço; entretanto, a competência médica e o adequado fluxo de realização de um procedimento são determinantes da qualidade final. Nesse contexto, a Sociedade Brasileira de Arritmias Cardíacas pretende recomendar parâmetros mínimos necessários para garantir a excelência dos serviços de monitorização eletrocardiográfica ambulatorial. OBJETIVOS: Recomendar competências médicas mínimas e as informações necessárias para emissão do laudo de Holter. MÉTODOS: O documento foi fundamentado no conceito de medicina baseada em evidência, e nas circunstâncias em que a evidência não estava disponível a opinião de uma comissão de redação foi utilizada para a formulação da recomendação. Essa comissão foi formada por profissionais que apresentam vivência nas dificuldades do método e gestão na prestação de serviços nessa área. RESULTADOS: O profissional responsável pela análise de Holter deve conhecer as patologias cardiovasculares e ter formação consistente em eletrocardiografia, incluindo arritmias cardíacas e seus diagnósticos diferenciais. O laudo deve ser redigido de forma clara e objetiva. Os parâmetros mínimos que devem constar no laudo incluem as estatísticas do exame, assim como quantificação e análise dos distúrbios do ritmo observados durante a monitorização. CONCLUSÃO: A monitorização eletrocardiográfica ambulatorial deve ser realizada por profissionais com vivência em análise eletrocardiográfica e o laudo deve conter os parâmetros mínimos mencionados nesse documento.

  13. Efeitos do tartarato de metoprolol em pacientes portadores de insuficiência cardíaca Effects of metoprolol tartrate therapy in patients with heart failure

    José Albuquerque de Figueiredo Neto

    2006-09-01

    Full Text Available OBJETIVO: Estudar os efeitos do tartarato de metoprolol em pacientes portadores de insuficiência cardíaca. MÉTODOS: Foram avaliados em estudo prospectivo, 50 pacientes (36 homens com insuficiência cardíaca, classe funcional II a IV, com 52±14,8 anos, e fração de ejeção do ventrículo esquerdo (FEVE 0,05. A freqüência cardíaca apresentou redução de 78,84±batimentos por minuto para 67,48±1,86 batimentos por minuto (pOBJECTIVE: To study the effects of metoprolol tartrate therapy in patients with heart failure. METHODS: Fifty patients (36 males aged 52±14.8 yrs, with functional class II to IV heart failure (HF and left ventricular ejection fraction (LVFE 0.05. Cardiac frequency decreased from 78.84±1.68 to 67.48±1.86 b.p.m. (p<0.001. CONCLUSION: The adding of metoprolol tartrate to the usual heart failure therapy is followed by an increase of ejection fraction, functional class improvement, and decrease of ventricular diameters and cardiac frequency. These results suggest anti-remodeling effects in patients with HF who utilize metoprolol tartrate in addition to the usual therapy.

  14. Muscle strain (image)

    A muscle strain is the stretching or tearing of muscle fibers. A muscle strain can be caused by sports, exercise, a ... something that is too heavy. Symptoms of a muscle strain include pain, tightness, swelling, tenderness, and the ...

  15. Muscle strain treatment

    Treatment - muscle strain ... Question: How do you treat a muscle strain ? Answer: Rest the strained muscle and apply ice for the first few days after the injury. Anti-inflammatory medicines or acetaminophen ( ...

  16. Nutritional Supplements for Endurance Athletes

    Rasmussen, Christopher J.

    Athletes engaged in heavy endurance training often seek additional nutritional strategies to help maximize performance. Specific nutritional supplements exist to combat certain factors that limit performance beginning with a sound everyday diet. Research has further demonstrated that safe, effective, legal supplements are in fact available for today's endurance athletes. Several of these supplements are marketed not only to aid performance but also to combat the immunosuppressive effects of intense endurance training. It is imperative for each athlete to research the legality of certain supplements for their specific sport or event. Once the legality has been established, it is often up to each individual athlete to decipher the ethics involved with ingesting nutritional supplements with the sole intent of improving performance.

  17. Regional Assessment of Supplementation Project

    The Fish and Wildlife Program of the Northwest Power Planning Council (NPPC) prescribes several approaches to achieve its goal of doubling the salmon and steelhead runs of the Columbia River. Among those approaches are habitat restoration, improvements in adult and juvenile passage at dams and artificial propagation. Supplementation will be a major part of the new hatchery programs. The purpose of the Regional Assessment of Supplementation Project (RASP) is to provide an overview of ongoing and planned supplementation activities, to construct a conceptual framework and model for evaluating the potential benefits and risks of supplementation and to develop a plan for better regional coordination of research and monitoring and evaluation of supplementation. RASP has completed its first year of work. Progress toward meeting the first year's objectives and recommendations for future tasks are contained in this report

  18. Muerte súbita cardíaca en mujer joven Sudden cardiac death in young woman

    M. Salguero Villadiego

    2003-10-01

    Full Text Available Presentamos un caso de muerte súbita cardíaca en una mujer joven sin patología arteriosclerótica en las arterias coronarias. En el miocardio y el aparato valvular no se preciaban alteraciones morfológicas. En la arteria coronaria desce ndente anterior se advierte un hematoma disecante que produce una oclusión completa de la luz vascular sin que existan evidencias morfológicas de degeneración quística de la media. Diagnóstico: Disección espontánea de la arteria coronaria descendente anterior.We present a case of sudden cardiac death in a young woman without arteriosclerotic pathology in the coronary arteries. In the myocardium and the valvular apparatus morphologic alterations were not appreciated. In the anterior coronary descending artery there is noticeable a dissecting hematoma that produces a complete occlusion of the vascular light without any morphologic evidence of cystic degeneracy of the tunica media. iagnosis: spontaneous dissection of the anterior coronary descending artery.

  19. Intervención psicológica en cirugía cardíaca

    Yalilis Castillero Amador

    2007-01-01

    Full Text Available La cirugía mayor y en particular la cirugía cardiovascularson una fuente potencial de estrés. Este artículo muestra la efectividad de la preparación psicológica en los pacientes sometidos a cirugía cardíaca. A través de una revisión de la literatura consideramos el impacto, tanto físico como psicológico, que tiene el padecer una enfermedad cardiovascular y el ser sometido a una cirugía del corazón.El corazón es un órgano al que se le atribuye un carácter de primacía en relación con los otros, por lo que existe un gran número de respuestas emocionalesante cualquier padecimiento relacionado con el mismo. Se puntualizan los beneficios de la intervenciónpsicológica en la cirugía y se propone un programa que facilite un adecuado afrontamiento y recuperación en la cirugía cardiovascular.

  20. Insuficiência cardíaca: expressões do conhecimento das pessoas sobre a doença

    Maria Teresa Silva de Freitas

    2013-08-01

    Full Text Available Pesquisa de natureza qualitativa que teve como objetivos caracterizar pessoas com Insuficiência Cardíaca (IC segundo perfil sócio-demográfico, de saúde e de tratamento e analisar o conhecimento sobre a doença e tratamento. Foram entrevistados 42 pacientes com IC, em um hospital de cardiologia de São Paulo, foi utilizado questionário semiestruturado e análise de conteúdo dos dados. Predominou sexo masculino, idade maior que 45 anos, classe funcional II, comorbidades associadas e tratamento farmacológico. Da análise de conteúdo emergiram as categorias: conhecimento sobre a doença e conhecimento do tratamento. O conhecimento é ilustrativo, diagnóstico e explicativo, sendo atribuídos muitos significados à doença. A maioria desconhece nome, dose e frequência de uso dos medicamentos. O tratamento não farmacológico está relacionado às orientações dos profissionais de saúde sobre alimentação, sal e ingesta hídrica. Os resultados abrem perspectivas para intervenções educativas sistematizadas que possam contribuir para um melhor enfrentamento e manejo da doença.

  1. Synthesis, crystal structure, and magnetism of A2Co12As7 (A=Ca, Y, Ce-Yb)

    Tan, Xiaoyan; Ovidiu Garlea, V.; Chai, Ping; Geondzhian, Andrey Y.; Yaroslavtsev, Alexander A.; Xin, Yan; Menushenkov, Alexey P.; Chernikov, Roman V.; Shatruk, Michael

    2016-04-01

    Ternary intermetallics, A2Co12As7 (A=Ca, Y, Ce-Yb), have been synthesized by annealing mixtures of elements in molten Bi at 1223 K. The materials obtained crystallize in the P63/m variant of the Zr2Fe12P7 structure type. The unit cell volume shows a monotonic decrease with the increasing atomic number of the rare-earth metal, with the exception of Ce-, Eu-, and Yb-containing compounds. An examination of these outliers with X-ray absorption near edge structures (XANES) spectroscopy revealed mixed valence of Ce, Eu, and Yb, with the average oxidation states of +3.20(1), +2.47(5), and +2.91(1), respectively, at room temperature. Magnetic behavior of A2Co12As7 is generally characterized by ferromagnetic ordering of Co 3d moments at 100-140 K, followed by low-temperature ordering of rare-earth 4f moments. The 3d-4f magnetic coupling changes from antiferromagnetic for A=Pr-Sm to ferromagnetic for A=Ce and Eu-Yb. Polarized neutron scattering experiments were performed to support the postulated ferro- and ferrimagnetic ground states for Ce2Co12As7 and Nd2Co12As7, respectively.

  2. Drugs, Herbs and Supplements: MedlinePlus

    ... https://medlineplus.gov/druginformation.html Drugs, Herbs and Supplements To use the sharing features on this page, ... included in drug packages, see DailyMed . Herbs and Supplements Browse dietary supplements and herbal remedies to learn ...

  3. Polimorfismo G894T da óxido nítrico-sintetase endotelial e o prognóstico na insuficiência cardíaca

    Oziel Marcio Araujo Tardin

    2013-10-01

    Full Text Available FUNDAMENTO: Estudos prévios avaliaram o papel do polimorfismo genético da enzima óxido nítrico-sintetase endotelial sobre o prognóstico na insuficiência cardíaca. Entretanto, faltam estudos relacionando o G894T e a insuficiência cardíaca na população brasileira. OBJETIVO: Avaliar a associação do G894T com o prognóstico de amostra de pacientes brasileiros com insuficiência cardíaca. MÉTODOS: Coorte com 145 pacientes com insuficiência cardíaca sistólica, num segmento de 40 meses (média = 22 meses, em dois hospitais universitários do Estado do Rio de Janeiro. Foi avaliada a relação do G894T com os desfechos: remodelamento reverso; melhora da classe funcional (NYHA; taxas de mortalidade e hospitalização. Os diâmetros do átrio e ventrículo esquerdos e a fração de ejeção do ventrículo esquerdo foram medidos na admissão e após 6 meses, para avaliação do remodelamento reverso. A melhora na classe funcional foi avaliada após 6 meses e as taxas de mortalidade e de hospitalização durante todo o seguimento. A raça foi autodeclarada. O polimorfismo G894T foi analisado por reação em cadeia de polimerase e por análise do polimorfismo dos fragmentos de restrição. RESULTADOS: A frequência genotípica foi GG (40%, GT (48,3% e TT (11,7%, e a frequência alélica foi guanina (64,1% e tiamina (35,8%. Não houve diferença entre as frequências genotípica ou alélica conforme a raça autodeclarada, tampouco conforme as características basais. Não houve relação entre o genótipo ou a frequência alélica e os desfechos analisados. CONCLUSÃO: Não se observou associação do polimorfismo G894T (Glu298Asp com o prognóstico de amostra de pacientes ambulatoriais brasileiros com insuficiência cardíaca sistólica.

  4. Effects of supplementation with L. plantarum TN8 encapsulated in alginate-chitosan in broiler chickens.

    Trabelsi, Imen; Ktari, Naourez; Ben Slima, Sirine; Bouchaala, Kamel; Ben Salah, Riadh

    2016-08-01

    This study was undertaken to investigate the effects of supplementation of probiotic strain Lactobacillus plantarum TN8 encapsulated in sodium alginate-chitosan or a commercial blend of essential oils on total cholesterol, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL) and growth performance of broiler chickens. The results showed that the broiler chickens supplemented with encapsulated L. plantarum TN8 or essential oil has a higher growth than the control group. After 35days, the weight means were 1860 and 1880g respectively in dietary supplementation with probiotic or essential oil, while they are 1800g in the control group. The evolution of the feed consumption and feed conversion per week showed that the supplementation of encapsulated TN8 strain or essential oil in broiler chickens food has a positive influence on their appetite. Similarly, supplementation of the feed with this encapsulated strain significantly reduced the rate of cholesterol (HDL and LDL) as well as the contents of triglycerides in broiler chickens. Through our study, it appears that the use of the probiotic supplementation or essential oil to broilers were found to be better than the control group of chickens, resulting in a significant economic impact and promoting effect on health. PMID:27181580

  5. Efeitos hemodinâmicos da combinação de dexmedetomidina-fentanil versus midazolam-fentanil em crianças submetidas à cirurgia cardíaca com circulação extracorpórea Efectos hemodinámicos de la combinación de dexmedetomidina-fentanil versus midazolam-fentanil en ninõs sometidos a la cirugía cardíaca con circulación extracorpórea Hemodynamic effects of the combination of dexmedetomidine-fentanyl versus midazolam-fentanyl in children undergoing cardiac surgery with cardiopulmonary bypass

    Jyrson Guilherme Klamt

    2010-08-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Avaliar a eficácia da infusão combinada de dexmedetomidina e fentanil na resposta hemodinâmica durante cirurgia cardíaca com circulação extracorpórea (CEC em crianças. MÉTODO: Trinta e duas crianças com idade entre 1 mês e 10 anos, agendadas para cirurgia cardíaca com circulação extracorpórea, foram distribuídas de modo aleatório em dois grupos: o Grupo MDZ recebeu midazolam 0,2 mg.kg-1.h-1, enquanto o Grupo DEX recebeu dexmedetomidina 1 µg.kg-1.h-1 durante uma hora e, em seguida, o ritmo de infusão foi reduzido à metade em ambos os grupos. Ambos os grupos receberam fentanil 10 µg.kg-1, midazolam 0,2 mg.h-1 e vecurônio 0,2 mg.kg-1 para indução da anestesia. As mesmas doses de fentanil com vecurônio da indução foram infundidas durante a primeira hora após a indução e, em seguida, reduzidas à metade. As infusões foram iniciadas imediatamente após a indução e mantidas até o final da cirurgia. O isoflurano foi administrado por curto tempo para controle da resposta hiperdinâmica à incisão e esternotomia. RESULTADOS: Em ambos os grupos, a pressão arterial sistólica e a frequência cardíaca reduziram de modo significativo após uma hora de infusão anestésica, porém o aumento da pressão arterial sistólica e diastólica e da frequência cardíaca à incisão da pele foram significantemente menores no Grupo DEX. Um número significativamente menor de pacientes demandaram suplementação com isoflurano no Grupo DEX. Após a CEC, os pacientes de ambos os grupos tiveram respostas hemodinâmicas similares. CONCLUSÕES: A infusão sem bolus de dexmedetomidina parece ser um adjuvante efetivo do fentanil na promoção de sedação e controle das respostas hemodinâmicas durante cirurgia para cardiopatias congênitas em crianças.JUSTIFICATIVA Y OBJETIVOS: Evaluar la eficacia de la infusión combinada de dexmedetomidina y fentanil en la respuesta hedominámica durante la cirugía cardíaca

  6. Dietary supplements containing prohibited substances.

    van der Bijl, P; Tutelyan, V A

    2013-01-01

    Dietary supplement use among athletes to enhance performance is proliferating as more individuals strive for obtaining that chemical competitive edge. As a result the concomitant use of dietary supplements containing performance-enhancing substances of those falling in the categories outlined in the current review, can also be expected to rise. This despite ever-increasing sophisticated analytical methodology techniques being used to assay dietary supplement and urine samples in doping laboratories. The reasons for this include that a variety of these chemical entities, many of them on the prohibited drug list of the WADA, are being produced on commercial scales in factories around the world (ephedrine and pseudoephedrine, sibutramine, methylhexaneamine, prohormones, 'classic' anabolic steroids, clenbuterol, peptide hormones etc.), aggressive marketing strategies are being employed by companies and these supplements can be easily ordered via e.g. the internet. It can also be anticipated that there will be an increase in the number of supplements containing 'designer' steroids and other 'newer' molecules. Chromatographic techniques combined with mass spectrometry leading to identification of molecular fragments and productions will assist in determining these substances. To prevent accidental doping, information regarding dietary supplements must be provided to athletes, coaches and sports doctors at all levels of competition. The risks of accidental doping via dietary supplement ingestion can be minimized by using 'safe' products listed on databases, e.g. such as those available in The Netherlands and Germany. PMID:24741950

  7. Perfil de saúde de pacientes acometidos por insuficiência cardíaca Perfil de la salud de los pacientes que sufren de insuficiencia cardíaca Health profile of patients suffering from heart failure

    Guilherme Abner Sousa Almeida

    2013-06-01

    Full Text Available O estudo objetivou caracterizar os clientes com diagnóstico de Insuficiência Cardíaca (IC, segundo o modelo de Campo de Saúde, identificando fatores de risco. O estudo, com abordagem quantitativa, foi realizado por meio de entrevista com 37 pacientes com diagnóstico médico de IC; utilizou-se questionário semiestruturado baseado no modelo de "Campo de Saúde". A média de idade dos pacientes foi de 60±15 anos, com predominância do sexo feminino (59,5% e da hipertensão arterial (75,7%. O consumo de bebidas alcoólicas e o tabagismo são praticados por, respectivamente, 13,5% e 21,6% dos pacientes. Os doces e refrigerantes são consumidos diariamente por 21,6% dos pacientes. O diagnóstico de IC é desconhecido por 75,7% dos pacientes e 40,5% procuram os serviços de saúde apenas em casos de urgência. Os determinantes da saúde que compõem o Campo de Saúde indicaram um meio propício para o surgimento da IC, prejudicando a qualidade de vida da população.Estudio que objetivó describir los clientes con un diagnóstico de Insuficiencia Cardíaca (IC, de acuerdo con el modelo de Campo de Salud, identificando factores de riesgo. Este es un estudio cuantitativo, realizado a través de entrevistas con 37 pacientes con diagnóstico de IC, utilizando cuestionario semiestructurado con base en el modelo de "Campo de Salud". La edad media de los pacientes fue de 60 ± 15 años, con predominancia del sexo femenino (59,5% y mayoría con hipertensión arterial (75,7%. El consumo de bebidas alcohólicas y el tabaquismo se llevan, respectivamente, un 13,5% y 21,6% de los pacientes. Los dulces y refrescos que se consumen a diario, en un 21,6% de los pacientes. El diagnóstico de IC es desconocido (75,7% y el 40,5% de los pacientes buscan servicios de salud sólo en situaciones de emergencia. Los determinantes de la salud que componen el Campo de Salud indicaron un medio favorable para la aparición de la IC, trayendo perjuicio para la calidad de

  8. China's Developing Dietary Supplement Industry

    Jeff Crowther

    2011-01-01

    @@ With the increasingly large size and forward momentum of China's economy, one would think there has to be a well-developed dietary supplement industry.However, although China has been posting re-cord gains to its GDP, it is far behind the U.S., E.U.and Japan in regard to a well-defined and prosperous dietary supplement industry.With that said, having an established dietary supple-ment industry is not the measure by which countries are judged in terms of economic prowess.

  9. Program Calibrates Strain Gauges

    Okazaki, Gary D.

    1991-01-01

    Program dramatically reduces personnel and time requirements for acceptance tests of hardware. Data-acquisition system reads output from Wheatstone full-bridge strain-gauge circuit and calculates strain by use of shunt calibration technique. Program nearly instantaneously tabulates and plots strain data against load-cell outputs. Modified to acquire strain data for other specimens wherever full-bridge strain-gauge circuits used. Written in HP BASIC.

  10. To supplement or not to supplement: a metabolic network framework for human nutritional supplements.

    Nogiec, Christopher D; Kasif, Simon

    2013-01-01

    Flux balance analysis and constraint based modeling have been successfully used in the past to elucidate the metabolism of single cellular organisms. However, limited work has been done with multicellular organisms and even less with humans. The focus of this paper is to present a novel use of this technique by investigating human nutrition, a challenging field of study. Specifically, we present a steady state constraint based model of skeletal muscle tissue to investigate amino acid supplementation's effect on protein synthesis. We implement several in silico supplementation strategies to study whether amino acid supplementation might be beneficial for increasing muscle contractile protein synthesis. Concurrent with published data on amino acid supplementation's effect on protein synthesis in a post resistance exercise state, our results suggest that increasing bioavailability of methionine, arginine, and the branched-chain amino acids can increase the flux of contractile protein synthesis. The study also suggests that a common commercial supplement, glutamine, is not an effective supplement in the context of increasing protein synthesis and thus, muscle mass. Similar to any study in a model organism, the computational modeling of this research has some limitations. Thus, this paper introduces the prospect of using systems biology as a framework to formally investigate how supplementation and nutrition can affect human metabolism and physiology. PMID:23967053

  11. To supplement or not to supplement: a metabolic network framework for human nutritional supplements.

    Christopher D Nogiec

    Full Text Available Flux balance analysis and constraint based modeling have been successfully used in the past to elucidate the metabolism of single cellular organisms. However, limited work has been done with multicellular organisms and even less with humans. The focus of this paper is to present a novel use of this technique by investigating human nutrition, a challenging field of study. Specifically, we present a steady state constraint based model of skeletal muscle tissue to investigate amino acid supplementation's effect on protein synthesis. We implement several in silico supplementation strategies to study whether amino acid supplementation might be beneficial for increasing muscle contractile protein synthesis. Concurrent with published data on amino acid supplementation's effect on protein synthesis in a post resistance exercise state, our results suggest that increasing bioavailability of methionine, arginine, and the branched-chain amino acids can increase the flux of contractile protein synthesis. The study also suggests that a common commercial supplement, glutamine, is not an effective supplement in the context of increasing protein synthesis and thus, muscle mass. Similar to any study in a model organism, the computational modeling of this research has some limitations. Thus, this paper introduces the prospect of using systems biology as a framework to formally investigate how supplementation and nutrition can affect human metabolism and physiology.

  12. Botanical Dietary Supplements: Background Information

    ... plant, but many compounds may be responsible for valerian' ;s relaxing effect. Are botanical dietary supplements safe? Many ... before their full effects are achieved. For example, valerian may be effective as a sleep aid after ...

  13. Medicare and Medicaid Statistical Supplement

    U.S. Department of Health & Human Services — The CMS Office of Enterprise Data and Analytics (OEDA) produced an annual Medicare and Medicaid Statistical Supplement report providing detailed statistical...

  14. Should You Take Dietary Supplements?

    ... Recognizing Cataracts Health Capsules Predicting Response to Breast Cancer Drugs Volunteers Needed ... You Take Dietary Supplements? A Look at Vitamins, Minerals, Botanicals and More When you reach for that bottle ...

  15. Inhibition of Streptococcus mutans strains by different mitis-salivarius agar preparations.

    Staat, R H

    1976-01-01

    Several Streptococcus mutans strains were markedly inhibited by mitis-salivarius agar manufactured by Baltimore Biological Laboratories, but little, if any, inhibition was noted using Difco Laboratories' mitis-salivarius agar. Supplementation of the basic medium with sucrose and bacitracin for specific selection of S. mutans resulted in suppression of representative S. mutans type a strains regardless of manufacturer. PMID:1270597

  16. Herbal Supplements: Cause for Concern?

    Paolo Borrione; Luigi Di Luigi; Nicola Maffulli; Fabio Pigozzi

    2008-01-01

    More than 1400 herbal products or herbal-derived compounds are commonly commercialised for health uses worldwide (Tyler, 1996). Herbs are considered dietary supplements, and therefore are subjected to a very limited form of regulation, and advertisements normally highlight their potential activities without mentioning any side effect. Also, herbs are generally believed to be 'natural', and hence safe. Many nutritional supplements contains herb compounds usually not present in the diet (e.g. G...

  17. Vitamin D supplementation in neonates.

    Wu, Zhe

    2014-01-01

    Vitamin D deficiency may lead to the development of rickets. In our paediatrics department in a major London hospital, we audited the number of babies with low vitamin D levels attending our prolonged jaundice clinic. Prior to our newly designed intervention, those babies with low vitamin D levels would be given a letter to encourage collection of supplementation from their GP. The GP would receive a letter which included a 14-page guideline on vitamin D supplementation. For this project, we included all breastfed babies that attended our prolonged jaundice clinic between August 2012 and December 2012. Those babies that were either vitamin D deficient or insufficient were identified. We then followed up these patients and asked them whether they were being prescribed the correct supplementation after being identified as vitamin deficient. For our intervention, we designed a leaflet to simplify guidelines that was then distributed to mothers and their GPs. Following this intervention, we re-audited the new cohort of patients who received the leaflet between August and November 2013. The study found 71% of babies to be vitamin D deficient. Moreover, almost two in five mothers had less than the recommended six months of vitamin supplementation during pregnancy. After identifying a deficiency, one would expect that uptake of vitamin supplementation would increase dramatically. However, only four in 10 babies went on to receive the correct dose and preparation of supplements. A marked increase in uptake was seen during the re-audit post intervention, with 71% of babies receiving correct supplementation. While an increase in government advertising would have contributed to the rise in uptake of vitamin D supplementation, a leaflet proved to be a simple yet effective intervention in improving vitamin uptake in babies. As a result, this was then implemented as part of trust guidelines. PMID:26733062

  18. Lesões cardíacas em ratos wistar inoculados com diferentes cepas do Trypanosoma cruzi

    E. Chapadeiro

    1988-09-01

    Full Text Available Ratos albinos Wistar infectados com diferentes inóculos das cepas Y, Colombiana (COL e São Felipe (12SF do Trypanosoma cruzi desenvolveram parasitemia elevada entre 14e21 dias, a qual tomou-se desprezível ou desapareceu completamente ao final da 4ª semana. As lesões do coração foram avaliadas, semiquantitativamente, pelo sistema de "scores", conforme a intensidade e a extensão da inflamação, nas diferentes estruturas do órgão, tendo sido observado que: a na fase inicial (aguda da infecção, os animais mortos espontaneamente ou em conseqüência de acidente anestésico apresentaram cardite de intensidade moderada à acentuada, não havendo diferença em relação às cepas utilizadas; as diferentes estruturas do coração estavam uniformemente comprometidas; b na fase crônica da infecção observou-se cardite degrau leve a moderado e as lesões foram mais freqüentes e intensas quanto maior o inoculo empregado; no entanto, inóculos baixos só produziram lesões quando a cepa utilizada foi a Colombiana. Trombose mural nos átrios e dilatação da ponta do ventrículo esquerdo foram observadas em 20% dos animais, independentemente da cepa. Na fase crônica 15% dos animais apresentaram miocardite crônica com fibrose, associada à hipertrofia das miocélulas. Os AA confirmam ser o rato albino suscetível à infecção chagásica e, portanto, um modelo útil no estudo das manifestações cardíacas da Doença de Chagas.

  19. Mineral supplementation for grazing ruminants

    Grazing ruminants to which concentrate feeds cannot be economically fed must rely on self-feeding of mineral supplements. A number of factors affect mineral consumption of free-choice mixtures. Livestock exhibit little nutritional wisdom and will select palatable mixtures in preference to mixtures designed to meet their requirements. Palatability and appetite stimulators are often used to achieve a more uniform herd-wide consumption. It is best to formulate free-choice mixtures on the basis of analyses or other available data. However, when no information on mineral status is known, a free-choice complete mineral supplement is warranted. A 'complete' mineral mixture usually includes salt, a low fluoride P source, Ca, Co, Cu, I, Mn and Zn. Selenium, Mg, K, S, Fe or additional elements can be incorporated into a mineral supplement as new information suggests a need. The detriment to ruminant production caused by providing Ca, Se and Cu in excess can be greater than any benefit derived by providing a mineral supplement. In regions where high forage Mo predominates, three to five times the Cu content in mineral mixtures is needed to counteract Mo toxicity. Supplemental minerals are most critical during the wet season, when cattle are gaining weight rapidly and energy and protein supplies are adequate. Economic return on mineral supplementation is high. (author)

  20. Mediastinite pós-esternotomia longitudinal para cirurgia cardíaca: 10 anos de análise

    Valdir Cesarino de Souza

    2002-09-01

    Full Text Available INTRODUÇÃO: mediastinites pós-esternotomia para cirurgia cardíaca não são freqüentes (0,2% a 5,0%, porém, quando surgem, se tornam potencialmente graves. Mesmo com o diagnóstico e tratamento precoces, o prognóstico não é bom, sobretudo se houver sepse e outros agravos à saúde associados. OBJETIVO: rever a casuística de casos de mediastinite. MÉTODO: foram analisados os prontuários de 2.272 pacientes submetidos à cirurgia cardíaca entre 1991 e 2000. Todas as operações foram realizadas através de esternotomia mediana longitudinal e circulação extracorpórea no Hospital João XXIII / Instituto de Cirurgia Cardiovascular da Paraíba de Campina Grande (Paraíba. RESULTADOS: a mediastinite ocorreu, em média, 10 dias após a cirurgia, num total de 37 (1,6% casos, com taxa de letalidade 21,6% (n=8. A maioria (n=19; 51,4% dos casos foi em pacientes submetidos a revascularização do miocárdio, seguidos pelos procedimentos valvares (n=13; 35,1%, correções de cardiopatias congênitas (n=4; 10,8% e aneurisma de aorta ascendente (n=1; 2,7%. Vários fatores de risco foram identificados (obesidade, tempo de permanência hospitalar prolongado, diabetes mellitus, tabagismo, reoperações e cirurgias de emergência, especialmente a permanência (por mais de 72 horas no pré-operatório em unidade de terapia intensiva. A cultura do exsudato foi positiva em 35 (94,6% dos 37 pacientes, sendo o Staphylococcus aureus o patógeno mais observado em 17 (48,6%. CONCLUSÕES: a freqüência de mediastinite pós-cirurgias cardíaca, com esternotomia associada, é semelhante à descrita na literatura, não tem diminuído no decorrer dos anos, por isto continua representando um desafio para os cirurgiões e equipes, apesar do arsenal diagnóstico e terapêutico atuais.INTRODUCTION: Mediastinitis is a rare though potentially fatal complication. The incidence is reported to be between 0.2% and 5.0% and is a major cause of postoperative morbidity

  1. Copper supplementation increases yeast life span under conditions requiring respiratory metabolism

    Kirchman, Paul A.; Botta, Gabriela

    2006-01-01

    To further exploit yeast as a model for cellular aging we have modified the replicative life span assay to force respiration, by replacing glucose with the non-fermentable carbon source glycerol. The growth rates of several different strains varied greatly, with doubling times ranging from 2.7 to 7 hours. Life spans of all strains were lower on media containing glycerol than on media containing glucose. However, supplementation of glycerol-containing media with copper resulted in increases in...

  2. 7 CFR 1924.49 - State supplements.

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false State supplements. 1924.49 Section 1924.49 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS... supplements. State Supplements or policies will not be issued or adopted to either supplement or...

  3. Food Supplement Usage by Adolescent Males.

    Fleischer, Barbara; Read, Marsha

    1982-01-01

    Adolescent males (N=568) responded to a questionnaire examining their food supplement usage, types of food supplements consumed, reasons for use and non-use, relationship of use to concern for health, and demographic and external factors influencing supplement use. Presents factors related to food supplement usage. (RC)

  4. Will the Affordable Care Act (ACA) Improve Racial/Ethnic Disparity of Eye Examination Among US Working-Age Population with Diabetes?

    Shi, Qian; Fonseca, Vivian; Krousel-Wood, Marie; Zhao, Yingnan; Nellans, Frank P; Luo, Qingyang; Shi, Lizheng

    2016-07-01

    This study aimed to examine the racial/ethnic disparity of eye examination rates among US adults with diabetes before and after the ACA. Working-age adults (18-64 years) with diabetes for years 2014-2017 were simulated by bootstrapping from the working-age diabetes patient sample of Medical Expenditure Panel Survey (MEPS) Household Component 2011. Insurance coverage rates were separately predicted for each racial/ethnic group based on the Congressional Budgeting Office (CBO) report in 2014 and the proportions of Medicaid eligibility. Eye examination rates were weighted to national estimates and compared between racial/ethnic groups. Confidence intervals were estimated using the bootstrap percentile method. Health insurance coverage after the ACA is projected to increase from 90.23 % in 2011 to 98.33 % in 2014 among non-Hispanic Whites (NHW), reaching 98.96 % in 2017. Minorities are forecasted to have about 15 % expansion of insurance coverage from 2011 (80.65 %) to 2014 (96.00 %), reaching 97.25 % in 2017. In 2011, 63.01 % of NHW had eye examinations with forecasted increase to 65.83 % in 2014 and 66.05 % in 2017, while the eye examination rate in the minorities will increase from 55.75 % in 2011 to 59.23 % in 2014 and remain at 59.48 % in 2017. Therefore, racial disparity in eye examination rates is forecasted to persist (ranging from 6.57 % in 2017 to 6.69 % in 2016). The ACA is projected to improve the eye examination rate along with the expansion in insurance coverage. Although predicted racial/ethnic disparities will improve, some differences will persist. Comprehensive strategies need to be developed to eliminate the disparity. PMID:27155608

  5. A calcium-dependent protein kinase can inhibit a calmodulin-stimulated Ca2+ pump (ACA2) located in the endoplasmic reticulum of Arabidopsis

    Hwang, I.; Sze, H.; Harper, J. F.; Evans, M. L. (Principal Investigator)

    2000-01-01

    The magnitude and duration of a cytosolic Ca(2+) release can potentially be altered by changing the rate of Ca(2+) efflux. In plant cells, Ca(2+) efflux from the cytoplasm is mediated by H(+)/Ca(2+)-antiporters and two types of Ca(2+)-ATPases. ACA2 was recently identified as a calmodulin-regulated Ca(2+)-pump located in the endoplasmic reticulum. Here, we show that phosphorylation of its N-terminal regulatory domain by a Ca(2+)-dependent protein kinase (CDPK isoform CPK1), inhibits both basal activity ( approximately 10%) and calmodulin stimulation ( approximately 75%), as shown by Ca(2+)-transport assays with recombinant enzyme expressed in yeast. A CDPK phosphorylation site was mapped to Ser(45) near a calmodulin binding site, using a fusion protein containing the N-terminal domain as an in vitro substrate for a recombinant CPK1. In a full-length enzyme, an Ala substitution for Ser(45) (S45/A) completely blocked the observed CDPK inhibition of both basal and calmodulin-stimulated activities. An Asp substitution (S45/D) mimicked phosphoinhibition, indicating that a negative charge at this position is sufficient to account for phosphoinhibition. Interestingly, prior binding of calmodulin blocked phosphorylation. This suggests that, once ACA2 binds calmodulin, its activation state becomes resistant to phosphoinhibition. These results support the hypothesis that ACA2 activity is regulated as the balance between the initial kinetics of calmodulin stimulation and CDPK inhibition, providing an example in plants for a potential point of crosstalk between two different Ca(2+)-signaling pathways.

  6. Fisher: a program for the detection of H/ACA snoRNAs using MFE secondary structure prediction and comparative genomics – assessment and update

    Tamas Ivica

    2008-07-01

    Full Text Available Abstract Background The H/ACA family of small nucleolar RNAs (snoRNAs plays a central role in guiding the pseudouridylation of ribosomal RNA (rRNA. In an effort to systematically identify the complete set of rRNA-modifying H/ACA snoRNAs from the genome sequence of the budding yeast, Saccharomyces cerevisiae, we developed a program – Fisher – and previously presented several candidate snoRNAs based on our analysis 1. Findings In this report, we provide a brief update of this work, which was aborted after the publication of experimentally-identified snoRNAs 2 identical to candidates we had identified bioinformatically using Fisher. Our motivation for revisiting this work is to report on the status of the candidate snoRNAs described in 1, and secondly, to report that a modified version of Fisher together with the available multiple yeast genome sequences was able to correctly identify several H/ACA snoRNAs for modification sites not identified by the snoGPS program 3. While we are no longer developing Fisher, we briefly consider the merits of the Fisher algorithm relative to snoGPS, which may be of use for workers considering pursuing a similar search strategy for the identification of small RNAs. The modified source code for Fisher is made available as supplementary material. Conclusion Our results confirm the validity of using minimum free energy (MFE secondary structure prediction to guide comparative genomic screening for RNA families with few sequence constraints.

  7. AVALIAÇÃO DE SAÚDE E DA DOR NO PÓS-OPERATÓRIO DE IDOSOS SUBMETIDOS À CIRURGIA CARDÍACA

    Thaiza Teixeira Xavier

    2011-01-01

    Full Text Available El presente estudio tiene como objetivo evaluar la salud y el dolor en pacientes ancianos con insuficiencia coronaria sometidos a cirugía cardíaca. Esta es una investigación de carácter analítico, transversal, con enfoque cuantitativo. La recolección de los datos se hizo por medio de una ficha de evaluación fisioterapéutica usando también la escala numérica de dolor, con 70 pacientes ancianos sometidos a cirugía cardíaca en dos hospitales en la ciudad de Natal/RN, Brasil. El rango de edad más frecuente fue de 60 a 69 años (61,43%, mayoría hombres (62,86%. En relación con el estado de salud el 61,43% de los sujetos tenían enfermedades preexistentes, siendo la de mayor distribución la hipertensión arterial (31.40%. El comportamiento del dolor fue moderado en el 1º y 3º días, y leve en el 2º y 4º días después de la operación. Por lo tanto, se constató que la mayoría de los pacientes ancianos sometidos a cirugía cardíaca eran del sexo masculino, que tenían patologías preexistentes, con la hipertensión arterial como la patología mas frecuente y con predominio de la intensidad del dolor moderado

  8. Why US children use dietary supplements

    Bailey, Regan L; Gahche, Jaime J; Thomas, Paul R.; Dwyer, Johanna T

    2013-01-01

    Background: Dietary supplements are used by one-third of children. We examined motivations for supplement use in children, the types of products used by motivations, and the role of physicians and health care practitioners in guiding choices about supplements. Methods: We examined motivations for dietary supplement use reported for children (from birth to 19 y of age; n = 8,245) using the National Health and Nutrition Examination Survey 2007–2010. Results: Dietary supplements were used by 31%...

  9. Efectividad de la metodología enfermera nanda – noc – nic en el control y seguimiento de pacientes con insuficiencia cardíaca

    Viñas Vera, Cipriano

    2015-01-01

    La insuficiencia cardíaca (IC) es un problema de salud prioritario. Presenta un gran impacto en la morbimortalidad, con gran repercusión en la dependencia y calidad de vida. Los costes son muy elevados, ya que los pacientes suelen reingresar y frecuentar el hospital bastante (Sayago-Silva et al., 2013). Se ha visto que para evitar la frecuentación hospitalaria es necesario incorporar alternativas asistenciales orientadas al autocuidado. Por otro lado, el manejo de la IC entre varones y mujere...

  10. Alterações da hemostasia em crianças submetidas a cirurgia cardíaca com circulação extracorpórea

    Silveira Fernanda Maria Rebouças da Costa; Lourenço Dayse Maria; Maluf Miguel; Carvalho Werther B.; Buffolo Enio; Carvalho Antonio Carlos

    1998-01-01

    OBJETIVO: Avaliar as alterações de hemostasia encontradas em crianças submetidas a cirurgia cardíaca com circulação extracorpórea (CEC). MÉTODOS: Estudamos 17 crianças no pré e pós-operatório (PO) imediato, no 1° PO e entre o 4º e 7º PO, analisando o hematócrito, tempo de protrombina (TP), tempo de tromboplastina parcial ativado, fibrinogênio, contagem de plaquetas, fator V e tempo de lise de euglobulina (TLE). Os pacientes foram divididos em grupos com e sem sangramento excessivo no PO. RESU...

  11. Caracterización del consumo de digoxina en la insuficiencia cardíaca en el municipio de Rodas (Cienfuegos, Cuba)

    Milián Vázquez, Pedro Miguel; Cepero Pérez, Ivette; Espinosa Brito, Alfredo; Padrón Velásquez, Luis; Hernández Fernández, Juana; Linares Borges, Arlette; Reyes Hernández, Dunia; Vázquez Montero, Lidia; Quirós Enríquez, Maira; Mass Sosa, Luis Alberto

    2004-01-01

    Se presenta un estudio descriptivo de corte transversal en pacientes mayores de 15 años con insuficiencia cardíaca que fueron tratados con digoxina en 15 consultorios médicos del municipio de Rodas, Cienfuegos, Cuba, en el primer semestre del 2003. Se estudiaron 130 pacientes registrados en la Farmacia Municipal. Se realizó una revisión de las historias clínicas individuales, hojas de egresos hospitalarios y entrevistas a los pacientes. La mayor parte de los pacientes que consumían digoxin...

  12. Pretensado y comportamiento mecánico del pericardio de ternera utilizado en la construcción de bioprótesis cardíacas

    Carrera, A.; García Pérez, J.M.; Jorge Herrero, E.; García Sestafé, José Vicente; Millán, I.J; Cordón, A.; Martín Maestro, M.; Calero, P.; Téllez, G.; Castillo Olivares, J.L.

    2001-01-01

    Este trabajo analiza las propiedades mecánicas de un tejido biológico, pericardio de bovino empleado como biomaterial en la fabricación de bioprótesis cardíacas. Para ello se sometió pericardio de ternera a un estrés de tracción, uniaxial, en escalones de carga, con retirada de dicha carga tras cada escalón. Los escalones de carga fueron de aproximadamente 2,3 y 8 MPa sucesivamente, continuándose finalmente el ensayo hasta la rotura. Se ensayaron 32 muestras, 16 tratadas con gl...

  13. Acupuntura na assistência de enfermagem ao paciente portador de arritmias cardíacas: pesquisa bibliográfica

    Márcio Rogério Bertuga; Vanessa Pellegrino Toledo

    2012-01-01

    Introdução: Entre as patologias cardíacas, parte dos eventos está relacionada com as arritmias. Inúmeros tratamentos são encontrados; medicamentosos e cirúrgicos; que nem sempre apresentam resultados satisfatórios, com uso de drogas que provocam reações adversas significativas e, a busca pela adequação da dosagem causa grande desconforto. As cirurgias são onerosas e nem sempre acessíveis aos sofredores de arritmias. Atualmente, busca-se por tratamentos alternativos, entre os quais, a Acupuntu...

  14. El silenciamiento del intercambiador Na+/H+ (NHE1) en mitocondrias cardíacas previene la apertura del poro de transición mitocondrial

    Villa-Abrille, M. C.; Cingolani, Horacio Eugenio; Cingolani, E; Álvarez, Bernardo Víctor

    2010-01-01

    Hasta el momento han sido descriptas diez isoformas del intercambiador Na+ /H+ (NHE1- NHE10), las cuales difieren en sus estructuras, distribución, localización, y sensibilidad ante diferentes estímulos. La inhibición del intercambiador Na+ /H+ (NHE1) reduce los daños producido por isquemia/reperfusión (I/R), hipertrofia e insuficiencia cardíaca. Si bien entre los mecanismos que subyacen al efecto protector mediado por bloqueo del NHE1 involucran el mantenimiento del potencial de membrana mit...

  15. Terapia génica da insuficiência cardíaca: potencial clínico da sobrexpressão da SERCA2a

    Oliveira, Diogo Fernando Gonçalves de

    2013-01-01

    Sendo responsáveis por cerca de 40% dos óbitos, as doenças cardiovasculares constituem a principal causa de morte em Portugal, constituindo também uma importante causa de incapacidade. Entre estas patologias, a insuficiência cardíaca assume um papel de destaque no que diz respeito à mortalidade e morbilidade das doenças cardiovasculares devido às crescentes taxas de incidência e prevalência. Apesar dos medicamentos das diferentes classes farmacológicas indicados para o tratamen...

  16. Comparação entre métodos de avaliação da modulação vagal cardíaca

    Vagner Clayton de Paiva

    2011-12-01

    Full Text Available FUNDAMENTO: Diversos métodos têm sido utilizados para avaliar a modulação vagal cardíaca; entretanto, há lacunas quanto a associação e acurácia desses métodos. OBJETIVO: Investigar a associação entre três métodos válidos, reprodutíveis e comumente utilizados para avaliação da modulação vagal cardíaca, e comparar as suas acurácias. MÉTODOS: Trinta homens saudáveis (23 ± 4 anos e 15 homens com coronariopatia (61 ± 10 anos foram avaliados em ordem contrabalanceada pela Variabilidade da Frequência Cardíaca (VFC; variáveis: domínio do tempo = pNN50, DPNN e RMSSD, domínio da frequência = AF ms² e AF u.n., Arritmia Sinusal Respiratória (ASR e Teste de Exercício de 4 segundos (T4s. RESULTADOS: Indivíduos saudáveis apresentaram maior modulação vagal nos três métodos (p < 0,05. No grupo saudável houve correlação (p < 0,05 entre os resultados da VFC (pNN50 e DPNN e da ASR, mas não houve correlação entre o T4s e os outros dois métodos estudados. No grupo com coronariopatia houve correlação entre os resultados da VFC (pNN50, DPNN, RMSSD, AF ms² e AF u.n. e da ASR. Em adição, houve correlação entre o T4s e a ASR. Por fim, os métodos ASR e T4s apresentaram tamanho do efeito mais preciso e melhor acurácia (p < 0,05 comparados à VFC. CONCLUSÃO: A VFC e a ASR geraram resultados parcialmente redundantes em indivíduos saudáveis e em pacientes com coronariopatia, enquanto o T4s gerou resultados complementares a VFC e ASR em indivíduos saudáveis. Além disso, os métodos ASR e T4s foram mais precisos para discriminar a modulação vagal cardíaca entre indivíduos saudáveis e pacientes com coronariopatia comparados à VFC.

  17. Fibrilação atrial no pós-operatório de cirurgia cardíaca: quem deve receber quimioprofilaxia?

    Glaucylara Reis Geovanini

    2009-04-01

    Full Text Available Avaliar fatores de risco arritmogênicos associados à maior incidência de fibrilação atrial (FA no pós-operatório (PO de cirurgia cardíaca (revascularização miocárdica e/ou cirurgia valvar, com o intuito de selecionar os mais propensos ao desenvolvimento dessa arritmia para possível quimioprofilaxia. Avaliarem-se 66 pacientes submetidos à cirurgia cardíaca eletiva. Correlacionaram-se os principais fatores de risco (idade avançada, doença valvar (DV, aumento atrial esquerdo (AE, disfunção ventricular (DVE, distúrbio eletrolítico (DHE, cirurgia cardíaca prévia (CCP, uso prévio e suspensão de betabloqueador (B-Bloq e/ou digital 24 horas antes da cirurgia para o desenvolvimento de FA no PO. A incidência de FA foi elevada (47% em nossa casuística e mais freqüente no primeiro dia de PO. Dos pacientes pesquisados, 64% eram do sexo masculino com idade média de 62 anos. Entre os pacientes com dois ou menos fatores de risco para FA, apenas 24% desenvolveram a arritmia, enquanto a presença de três ou mais desses fatores esteve associada à sua maior incidência no PO (69%, (p = 0,04. Em ordem de maior freqüência, idade > 65 anos (em 58% dos pacientes foi o fator de risco mais prevalente, seguido de aumento do AE em 45% (p = 0,001 e DV em 38% (p = 0,02. A presença de três ou mais fatores de risco aumenta consideravelmente a incidência dessa arritmia no PO de cirurgia cardíaca. Entre os principais fatores, destacaram-se idade avançada, aumento do AE e doença valvar.

  18. Estrategia de acceso al alimento y estado nutricional de la población celíaca adulta de la ciudad de Mar del Plata

    Tuerdovsky, Natalia

    2010-01-01

    La enfermedad celíaca es una intolerancia del intestino delgado al gluten, proteína que se encuentra en el germen del trigo, el centeno, la cebada y la avena. La prevalencia de la misma ha aumentado, en Argentina es de 1 caso cada 167 individuos sanos. El diagnóstico se realiza mediante biopsia intestinal y el tratamiento consiste en una dieta libre de gluten. Se conoce que el precio de éstos productos es elevado, por lo que no todos pueden acceder a ellos.El problema de la pre...

  19. Insuficiência cardíaca. Uma epidemia do século XXI. O desafio do diagnóstico

    Fonseca, Maria Cândida Faustino Gamito da

    2008-01-01

    Resumo: A insuficiência cardíaca, já denominada de epidemia do século XXI é, de entre as doenças cardiovasculares, a única cuja incidência e prevalência continuam a crescer, apesar dos imensos progressos feitos na área da terapêutica nas últimas duas décadas. Caracteriza-se por elevada mortalidade – superior à do conjunto das neoplasias malignas -, grande morbilidade, consumo de recursos e custos exuberantes. É um dos problemas mais graves de Saúde Pública dos Países industrializados, cujo ma...

  20. Aneurisma de artéria ilíaca interna roto: relato de caso Ruptured internal iliac artery aneurysm: case report

    Cristina Toledo Afonso

    2009-03-01

    Full Text Available Aneurismas isolados da artéria ilíaca interna são raros, acometem 0,1% da população e correspondem a 1% dos aneurismas aorto-ilíacos. Na maioria das vezes, os pacientes são assintomáticos, mas podem apresentar dor abdominal, massa pulsátil no hipogástrio ou na fossa ilíaca, sintomas compressivos urinários, gastrointestinais ou neurológicos. Podem ocasionar quadro de abdome agudo, principalmente quando há ruptura. O diagnóstico precoce dos aneurismas isolados de artéria ilíaca interna é incomum, sendo identificados quando mais volumosos ou rotos, o que aumenta significativamente sua morbimortalidade e torna seu prognóstico mais reservado. Dessa forma, representam um desafio terapêutico. A ligadura cirúrgica tem sido o tratamento mais comum, entretanto a cirurgia endovascular tem mostrado bons resultados, inclusive nos aneurismas rotos. É relatado caso de aneurisma de artéria ilíaca interna isolado roto diagnosticado durante laparotomia para abordagem de abdome agudo.Isolated internal iliac artery aneurysms are rare. They affect 0.1% of the population, and account for 1% of aortoiliac aneurysms. Patients are mostly asymptomatic, yet they can have abdominal pain, pulsatile mass in the hypogastrium or iliac fossa, or urinary, gastrointestinal or neurological compressive symptoms. Such aneurysms are likely to course with an acute abdomen, especially when ruptured. Early diagnosis of isolated internal iliac artery aneurysms is difficult, as they are more easily detected when larger or ruptured, which significantly raises their morbidity and mortality rate and determines a poor prognosis. Therefore, they are a therapeutic challenge. Surgical ligation has been the most common treatment; however, the endovascular approach has presented good outcomes, even in the event of ruptured aneurysms. A case of ruptured isolated iliac artery aneurysm diagnosed during a laparotomy (acute abdomen approach is reported.

  1. Probiotics supplementation for athletes - clinical and physiological effects.

    Pyne, David B; West, Nicholas P; Cox, Amanda J; Cripps, Allan W

    2015-01-01

    Probiotic supplementation has traditionally focused on gut health. However, in recent years, the clinical applications of probiotics have broadened to allergic, metabolic, inflammatory, gastrointestinal and respiratory conditions. Gastrointestinal health is important for regulating adaptation to exercise and physical activity. Symptoms such as nausea, bloating, cramping, pain, diarrhoea and bleeding occur in some athletes, particularly during prolonged exhaustive events. Several studies conducted since 2006 examining probiotic supplementation in athletes or highly active individuals indicate modest clinical benefits in terms of reduced frequency, severity and/or duration of respiratory and gastrointestinal illness. The likely mechanisms of action for probiotics include direct interaction with the gut microbiota, interaction with the mucosal immune system and immune signalling to a variety of organs and systems. Practical issues to consider include medical and dietary screening of athletes, sourcing of recommended probiotics and formulations, dose-response requirements for different probiotic strains, storage, handling and transport of supplements and timing of supplementation in relation to travel and competition. PMID:25339255

  2. Strains and Sprains

    ... ON THIS TOPIC Sports Medicine Center Preventing Children's Sports Injuries Computer-Related Repetitive Stress Injuries Knee Injuries Broken ... Knee Injuries Sports and Exercise Safety Dealing With Sports Injuries Groin Strain Ankle Sprains Strains and Sprains Stretching ...

  3. O polimorfismo AGT*M235T na disfunção cardíaca de etiologia isquêmica aguda: projeto gisca AGT*M235T polymorphism in acute ischemic cardiac dysfunction: the gisca project

    Claudia Guerra Murad Saud; Amália Faria dos Reis; Arlisa Monteiro de Castro Dias; Rosemery Nunes Cardoso; Ana Cristina Klem Vargas Carneiro; Leandro Pereira de Souza; Ana Beatriz Monteiro Fonseca; Georgina Severo Ribeiro; Carlos Augusto Cardozo de Faria

    2010-01-01

    FUNDAMENTO: O polimorfismo AGT*M235T tem sido associado a elevados níveis séricos de angiotensinogênio (AGT), hipertensão arterial sistêmica e disfunção cardíaca (DC). OBJETIVO: Testar a hipótese de haver associação entre polimorfismo AGT*M235T e o risco de desenvolver disfunção cardíaca (insuficiência cardíaca ou disfunção sistólica ventricular esquerda assintomática) pós-síndrome coronariana aguda (SCA), durante o período de internação hospitalar. MÉTODOS: Foram estudados 363 pacientes (ida...

  4. Estudo do perfil metabólico da caquéxia cardíaca, através de um modelo animal, utilizando 2H2O

    Barra, Joana Sofia Rodrigues

    2010-01-01

    A Caquéxia Cardíaca é uma condição decorrente de um estado avançado da insuficiência cardíaca, caracterizada por uma mudança em toda a actividade metabólica do corpo, que conduz a um saldo nutricional negativo e à perda de massa proteica corporal. Como a caquéxia cardíaca avançada está associada a uma alta taxa de mortalidade, existe um grande interesse no desenvolvimento de marcadores, que permitam elaborar um diagnóstico, ainda numa fase inicial, onde as intervenções são mais eficazes. A pe...

  5. Parada cardíaca súbita em anestesia geral como a primeira manifestação da origem anômala de artéria coronária esquerda

    Maurício Daher; André Rodrigues Zanatta; Benhur David Henz; Marcelo Carneiro da Silva; Simone Nascimento dos Santos; Luiz Roberto Leite

    2012-01-01

    JUSTIFICATIVA E OBJETIVOS: O relato de caso descreve uma situação rara e potencialmente fatal associada à administração de anestesia. Nosso objetivo foi discutir as causas de parada cardíaca súbita no período perioperatório em pacientes aparentemente saudáveis e a fisiopatologia das anomalias de origem das artérias coronárias como uma causa de parada cardíaca súbita. RELATO DE CASO: Uma mulher de 44 anos, sem sintomas prévios de doença coronariana ou arritmias, apresenta parada cardíaca súbit...

  6. Strained Silicon Photonics

    Wehrspohn, Ralf B; Jörg Schilling; Christian Bohley; Clemens Schriever

    2012-01-01

    A review of recent progress in the field of strained silicon photonics is presented. The application of strain to waveguide and photonic crystal structures can be used to alter the linear and nonlinear optical properties of these devices. Here, methods for the fabrication of strained devices are summarized and recent examples of linear and nonlinear optical devices are discussed. Furthermore, the relation between strain and the enhancement of the second order nonlinear susceptibility is inves...

  7. Finite Element Simulation of Flexible Roll Forming with Supplemented Material Data and the Experimental Verification

    YAN Yu; WANG Haibo; LI Qiang; GUAN Yanzhi

    2016-01-01

    Flexible roll forming is a promising manufacturing method for the production of variable cross section products. Considering the large plastic strain in this forming process which is much larger than that of uniform deformation phase of uniaxial tensile test, the widely adopted method of simulating the forming processes with non-supplemented material data from uniaxial tensile test will certainly lead to large error. To reduce this error, the material data is supplemented based on three constitutive models. Then a finite element model of a six passes flexible roll forming process is established based on the supplemented material data and the original material data from the uniaxial tensile test. The flexible roll forming experiment of a B pillar reinforcing plate is carried out to verify the proposed method. Final cross section shapes of the experimental and the simulated results are compared. It is shown that the simulation calculated with supplemented material data based on Swift model agrees well with the experimental results, while the simulation based on original material data could not predict the actual deformation accurately. The results indicate that this material supplement method is reliable and indispensible, and the simulation model can well reflect the real metal forming process. Detailed analysis of the distribution and history of plastic strain at different positions are performed. A new material data supplement method is proposed to tackle the problem which is ignored in other roll forming simulations, and thus the forming process simulation accuracy can be greatly improved.

  8. Environmental Report 1999 Data Supplement

    Larson, J M; Biermann, A H; Harrach, R J; Althouse, P E; Bertoldo, N A; Blake, R G; Brandstetter, E R; Brigdon, S L; Brown, R A; Christofferson, E; Folks, K J; Gallegos, G M; Garcia, L M; Giesing, T A; Grayson, A R; Hall, L C; MacQueen, D H; Mathews, S; Peterson, S R; Taffet, M J; Tate, P J; Vellinger, R J; Ward, R J; Williams, R A

    2000-09-01

    This Data Supplement to the Lawrence Livermore National Laboratory's (LLNL's) annual ''Environmental Report 1999'' was prepared for the U.S. Department of Energy. The main volume is intended to provide all information on LLNL's environmental impact and compliance activities that is of interest to most readers. The Data Supplement supports main volume summary data and is essentially a detailed data report that provides individual data points, where applicable. Some summary data are also included in the Data Supplement, and more detailed accounts are given of sample collection and analytical methods. The two volumes are organized in a parallel fashion to aid the reader in cross-referencing between them. This supplement includes more detailed information to support the nine chapters in the main volume that cover monitoring of air, air effluent, sewerable water, surface water, ground water, soil and sediment, vegetation and foodstuff, environmental radiation, and quality assurance. The other five chapters in the main volume have no supporting information in the Data Supplement. As in our previous annual reports, data are presented in Systeme International (SI) units. In particular, the primary units used for radiological results are becquerels and sieverts for activity and dose, with curies and rem used secondarily (1 Bq = 2.7 x 10{sup -11} Ci; 1 Sv = 100 rem).

  9. Environmental Report 2000 Data Supplement

    Biermann, A H; Althouse, P E; Bertoldo, N A; Blake, R G; Brigdon, S L; Brown, R A; Campbell, C G; Christofferson, E; Clark, L M; Folks, K J; Gallegos, G M; Grayson, A R; Harrach, R J; Larson, J M; MacQueen, D H; Mathews, S; Nisbet, B; Ring Peterson, S; Taffet, M J; Tate, P J; Vellinger, R J; Williams, R A

    2001-09-01

    This Data Supplement to the Lawrence Livermore National Laboratory's (LLNL's) annual ''Environmental Report 2000'' was prepared for the U.S. Department of Energy. The main volume is intended to provide all information on LLNL's environmental impact and compliance activities that is of interest to most readers. The Data Supplement supports main volume summary data and is essentially a detailed data report that provides individual data points, where applicable. Some summary data are also included in the Data Supplement, and more detailed accounts are given of sample collection and analytical methods. The two volumes are organized in a parallel fashion to aid the reader in cross-referencing between them. This supplement includes more detailed information to support the nine chapters in the main volume that cover monitoring of air surveillance, air effluent, sewerable water, surface water, groundwater, soil and sediment, vegetation and foodstuff, environmental radiation, and quality assurance. The other five chapters in the main volume have no supporting information in the Data Supplement. As in our previous annual reports, data are presented in Systeme International (SI) units. In particular, the primary units used for radiological results are becquerels and sieverts for activity and dose, with curies and rem used secondarily (1 Bq = 2.7 x 10{sup -11} Ci; 1 Sv = 100 rem).

  10. Lignocellulosic bioethanol production with revalorization of low-cost agroindustrial by-products as nutritional supplements

    Kelbert, Maikon; Romaní, Aloia; Coelho, Eduardo; Pereira, Francisco B.; Teixeira, J.A.; Domingues, Lucília

    2015-01-01

    During the pretreatment of lignocellulosic biomass for second generation bioethanol production, fermentation inhibitors are released. To overcome this, the use of a robust industrial strain together with agro-industrial by-products as nutritional supplementation was proposed to increase ethanol productivity and yields. Two factorial experimental designs were carried out to optimize fermentation of hydrolysate from autohydrolysis of Eucalyptus globulus. The mostinfluential variable...

  11. Preditores de letalidade hospitalar em pacientes com insuficiência cardíaca avançada Predictors of in-hospital lethality in patients with advanced heart failure

    Adriana Lopes Latado; Luiz Carlos Santana Passos; Julio C. V. Braga; Alessandra Santos; Rodrigo Guedes; Simone S. Moura; Daniela Almeida

    2006-01-01

    OBJETIVO: Descrever as características clínicas e identificar potenciais fatores de risco para letalidade hospitalar em pacientes com insuficiência cardíaca descompensada, admitidos em unidade de terapia intensiva. MÉTODOS: Pacientes consecutivamente admitidos por insuficiência cardíaca descompensada numa unidade de terapia intensiva, de junho/2001 a dezembro/2003, foram selecionados e seguidos durante a internação. Características clínicas na admissão foram coletadas e avaliadas por meio de ...

  12. Comparação de critérios diagnósticos de insuficiência renal aguda em cirurgia cardíaca Comparison of diagnostic criteria for acute kidney injury in cardiac surgery

    Márcio Campos Sampaio; Carlos Alberto Gonçalves Máximo; Carolina Moreira Montenegro; Diandro Marinho Mota; Tatiana Rocha Fernandes; Antonio Carlos Mugayar Bianco; Celso Amodeo; Antonio Carlos Cordeiro

    2013-01-01

    FUNDAMENTO: Há grande controvérsia quanto ao diagnóstico de Insuficiência Renal Aguda (IRA), existindo mais de 30 diferentes definições. OBJETIVO: Avaliar a incidência e os fatores de risco para desenvolvimento de IRA no pós-operatório de cirurgia cardíaca de acordo com os critérios RIFLE, AKIN e KDIGO, e comparar o poder prognóstico desses critérios. MÉTODOS: Estudo de corte transversal que incluiu 321 pacientes (62 [53 - 71] anos, 140 homens) consecutivamente submetidos a cirurgia cardíaca ...

  13. Complicações que aumentam o tempo de permanência na unidade de terapia intensiva na cirurgia cardíaca Complications that increase the time of Hospitalization at ICU of patients submitted to cardiac surgery

    Artur Laizo; Francisco Eduardo da Fonseca Delgado; Glauco Mendonça Rocha

    2010-01-01

    OBJETIVO: Apresentar as complicações que aumentam a permanência na Unidade de Terapia Intensiva (UTI) dos pacientes submetidos à cirurgia cardíaca. MÉTODOS: Foram analisados, retrospectivamente, 85 prontuários de pacientes submetidos à cirurgia cardíaca, no período de março a maio de 2009, na Santa Casa de Misericórdia de Juiz de Fora (MG) e, destes pacientes, foram estudados 14 (16,47%) que permaneceram por mais de 5 dias na UTI. Dentre os 85 pacientes, houve três óbitos, sendo dois paciente...

  14. Nutritional Supplements for Strength Power Athletes

    Wilborn, Colin

    Over the last decade research involving nutritional supplementation and sport performance has increased substantially. Strength and power athletes have specific needs to optimize their performance. Nutritional supplementation cannot be viewed as a replacement for a balanced diet but as an important addition to it. However, diet and supplementation are not mutually exclusive, nor does one depend on the other. Strength and power athletes have four general areas of supplementation needs. First, strength athletes need supplements that have a direct effect on performance. The second group of supplements includes those that promote recovery. The third group comprises the supplements that enhance immune function. The last group of supplements includes those that provide energy or have a direct effect on the workout. This chapter reviews the key supplements needed to optimize the performance and training of the strength athlete.

  15. Is vitamin C supplementation beneficial?

    Lykkesfeldt, Jens; Poulsen, Henrik Enghusen

    2010-01-01

    In contrast to the promised ‘antioxidant miracle' of the 1980s, several randomised controlled trials have shown no effect of antioxidant supplements on hard endpoints such as morbidity and mortality. The former over-optimistic attitude has clearly called for a more realistic assessment of the...... benefit:harm ratio of antioxidant supplements. We have examined the literature on vitamin C intervention with the intention of drawing a conclusion on its possible beneficial or deleterious effect on health and the result is discouraging. One of several important issues is that vitamin C uptake is tightly...... controlled, resulting in a wide-ranging bioavailability depending on the current vitamin C status. Lack of proper selection criteria dominates the currently available literature. Thus, while supplementation with vitamin C is likely to be without effect for the majority of the Western population due to...

  16. Papel do óxido nítrico no desenvolvimento de lesões cardíacas na fase aguda da infecção experimental pelo Trypanosoma cruzi Role of nitric oxide in the development of cardiac lesions during the acute phase of experimental infection by Trypanosoma cruzi

    Cláudia Renata Bibiano Borges

    2009-04-01

    Full Text Available A doença de Chagas é causada pelo Trypanosoma cruzi e o coração é o órgão mais acometido. O óxido nítrico apresenta importante ação anti-Trypanosoma, porém, com pouca evidência de seu papel no mecanismo de lesão tecidual. O objetivo deste estudo foi analisar a contribuição do óxido nítrico no desenvolvimento da inflamação e da fibrose cardíaca na fase aguda da infecção experimental por cepas Y e Colombiana do Trypanosoma cruzi. A inflamação foi significativamente maior nos animais infectados pela cepa Colombiana, comparada com os infectados com a cepa Y, tanto nos animais C57BL/6 (3,98x1,87%; p=0,004 quanto nos animais C57BL/6 deficientes na sintase do óxido nítrico induzível (3,99x2,4%; p=0,013. O parasitismo cardíaco dos animais C57BL/6 deficientes na sintase do óxido nítrico induzível infectados pela cepa Colombiana foi significativamente maior que o destes mesmos animais infectados com a cepa Y (2,78x0,17 ninhos/mm²; p=0,004 assim como, os animais C57BL/6 infectados com a cepa Colombiana (2,78x1,33 ninhos/mm²; p=0,006 ou cepa Y (2,78x0,53 ninhos/mm²; p=0,005. Os dados reforçam o papel do óxido nítrico no controle do parasitismo e sugerem seu papel na proteção tecidual, controlando a inflamação e potencialmente diminuindo lesões cardíacas durante a fase aguda na doença de Chagas experimental.Chagas disease is caused by Trypanosoma cruzi and the heart is the organ most affected. Nitric oxide has notable anti-Trypanosoma action, but with little evidence regarding its role in the mechanism for tissue injury. The objective of this study was to analyze the contribution of nitric oxide towards the development of inflammation and cardiac fibrosis during the acute phase of experimental infection by Y and Colombian strains of Trypanosoma cruzi. The inflammation was significantly more intense in animals infected with the Colombian strain, compared with those infected with the Y strain, both in C57BL/6

  17. Associação entre autocuidado e reinternação hospitalar de pacientes com insuficiência cardíaca

    Amanda Chlalup Linn

    2016-06-01

    Full Text Available RESUMO Objetivo: verificar associação entre o autocuidado e o número de reinternações hospitalares de pacientes com diagnóstico de insuficiência cardíaca (IC descompensada, bem como testar a aplicabilidade de dois instrumentos de avaliação de autocuidado. Estudo longitudinal, realizado em um hospital de referência cardiológica do sul do Brasil. Método: foram incluídos 82 pacientes, com idade média de 61,85±12,33 anos, 57,3% do sexo masculino. O escore médio da avaliação de autocuidado encontrado pelas escalas European Heart Failure Self-care Behavior Scale e a Escala de Autocuidado para Pacientes com Insuficiência Cardíaca foi insatisfatório. Resultados: foi verificada uma média de 2,57±1,66 reinternações hospitalares no último ano por descompensação da IC. Houve correlação entre os escores de autocuidado com número de reinternações hospitalares por IC descompensada. Escolaridade e idade mostraram-se associadas ao autocuidado dos pacientes com IC. Conclusão: ambas as escalas avaliam o autocuidado de forma relevante, sendo correlacionados os seus índices.

  18. Biologia de Sistemas Aplicada à Insuficiência Cardíaca com Fração de Ejeção Normal

    Evandro Tinoco Mesquita

    2014-05-01

    Full Text Available A insuficiência cardíaca com fração de ejeção normal (ICFEN é, atualmente, o fenótipo clínico mais prevalente de insuficiência cardíaca e os tratamentos disponíveis não apresentam redução na mortalidade. Avanços na disciplina de ciências ômicas e em técnicas de elevado processamento de dados empregados na biologia molecular possibilitaram o desenvolvimento de uma abordagem integrativa da ICFEN baseada na biologia de sistemas. O objetivo deste trabalho foi apresentar um modelo da ICFEN baseado na biologia de sistemas utilizando as abordagens bottom-up e top-down. Realizou-se uma pesquisa na literatura de estudos publicados entre 1991-2013 referentes à fisiopatologia da ICFEN, seus biomarcadores e sobre a biologia de sistemas com o desenvolvimento de um modelo conceitual utilizando as abordagens bottom-up e top-down da biologia de sistemas. O emprego da abordagem de biologia de sistemas para ICFEN, a qual é uma síndrome clínica complexa, pode ser útil para melhor entender sua fisiopatologia e descobrir novos alvos terapêuticos.

  19. Limiar anaeróbico (V4 e frequência cardíaca de cavalos Crioulos condicionados para prova funcional

    L.A. Amaral

    2013-02-01

    Full Text Available Determinou-se o limiar anaeróbico (V4 de 23 cavalos Crioulos hígidos em treinamento. Os animais selecionados foram submetidos a testes de desempenho, composto por três etapas de velocidade progressiva de 6m/s, 8m/s e 10m/s, com duração de cinco minutos cada etapa, até que fosse atingida a concentração de 4mmol/dL de lactato sanguíneo. As concentrações de lactato sanguíneo elevaram-se a partir da velocidade de exercício de 6,0m/s, sendo que 20 animais (90% atingiram 4mmol/L de lactato na velocidade entre 6 - 8m/s, com média de frequência cardíaca que variou de 121 a 140bpm. Concluiu-se que a V4 do cavalo Crioulo está entre as velocidades de 6 - 8m/s e a frequência cardíaca entre 121 - 140bpm.

  20. Dolor de la articulación sacroilíaca: Anatomía, Diagnóstico y Tratamiento Sacroiliac joint pain: Anatomy, Diagnosis and Treatment

    G. E. Mejía

    2008-04-01

    Full Text Available El dolor de la articulación sacroilíaca es una causa frecuente de dolor bajo de espalda, sin embargo el diagnóstico de artralgia sacroilíaca no es fácil de confirmar y la exploración física de la articulación es controvertido. Además este diagnóstico a menudo pasa inadvertido para el médico, por lo que la falta de consideración de esta posible causa de lumbalgia da lugar a tratamientos inapropiados e inadecuados. La articulaciones sacroilíacas, sinoviales del tipo anfiartrosico irregular, monoaxiales, en la cual se articulan las carillas articulares del sacro al ilion, Su innervación es cuestión de debate, pero las más recientes investigaciones refieren que deriva de L2-S2, L4-S2, L5-S2. La prevalencia del dolor de la articulación sacroilíaca no esta bien estudiado, hay numerosas etiologías para el dolor de articulación sacroilíaca, estas causas se pueden dividir en intraarticulares y extraarticulares. Para la exploración física se cuenta con una serie de 12 pruebas las cuales fueron emitidas por un comité de expertos y se concluye que encontrar 3 o más pruebas positivas es muy sugestivo de dolor de dicha. El tratamiento se puede dividir en conservador, intervencionista donde se puede utilizar desde la infiltración con anestésico local y esteroide hasta radiofrecuencia y por ultimo quirúrgico para casos seleccionados.The pain of the sacroiliac joint is a frequent cause of low back pain, however the diagnose of sacroiliac artralgia it is not easy to confirm and the physical exploration of the joint is controversial. Also this I often diagnose it happens inadvertent for the physician, for what the lack of consideration of this possible low back pain cause gives place to inappropriate and inadequate treatments. The sacroiliac joint is synovial of the type irregular anphiarthrosic, monoaxial, in which the sides joint are articulated from the sacrum one to the Ilion, Their innervation is debate question, but those but

  1. COMPARATIVE STUDY OF FOOD SUPPLEMENTS USED ON THE ACTIVITY OF KINETIC ENDURANCE CHARAKTER APPLIED AS A CARDIOVASCULAR DISEASES PREVENTION

    DIČE, Michal

    2009-01-01

    The aim of this thesis is to compare food supplements used on the activity of endurance character and their influence on the cardiovascular system. The teoretical part is pursued to the basic food components and their metabolism and to kinetic activities splitting. The practical part gives information about splitting of sports supplements used on the activity of endurance character, their usage and effects. It deals with the question of human organism behaviour during the strain of endurance ...

  2. Food irradiation : ACA inquiry

    The executive summary of the report on food irradiation by the Australian Consumers' Association is presented. The key issues which emerged during the inquiry are summarised including safety controls, wholesomeness, the environment, consumer rights and economic considerations

  3. Supplements to Traditional Vocabulary Teaching

    布亚男

    2012-01-01

      In a word, Vocabulary plays an indispensable part in language proficiency and provides much of the basis of how wel learns language, so it cannot be ignored. I discussed Schools’ viewpoints on the vocabulary teaching ,Reason for forgetting, Traditional approach to vocabulary teaching, supplements to vocabulary teaching,the author hope the above content can offer some hints for language learners.

  4. Herbal Supplements and Sport Performance

    Ellen Coleman; Ron Maughan; Sozanne Nelson Steen; Rob Skinner

    2008-01-01

    @@ KEY POINTS ·Labels on dietary supplements can be misleading. Containers may include substantially more,but usually less,of the listed amounts of ingredients,and substances may be added? some of which can cause failed doping tests for athletes?

  5. Multidimensional evaluation of the elderly undergoing cardiac surgery Evaluación multidimensional de ancianos sometidos a cirugía cardíaca Avaliação multidimensional de idosos submetidos à cirurgia cardíaca

    Marinez Kellermann Armendaris

    2012-01-01

    salud, así como también, remite a la necesidad de un abordaje integral en salud que refleje en mejora de su calidad de vida.OBJETIVO: Conhecer aspectos multidimensionais do idoso submetido à cirurgia cardíaca. MÉTODOS: Estudo epidemiológico descritivo, realizado no Instituto de Cardiologia do Distrito Federal-IC/DF. Utilizou-se para a coleta de dados instrumento contendo as variáveis: sócio demográficas, clínicas, scores de avaliação da função cognitiva,capacidade funcional e emocional. Testes do Qui-quadrado e T de Student foram empregados para a análise dos dados. RESULTADOS: Da população total, 64% era do sexo feminino; Idosos não alfabetizados e com formação mínima, somados, representavam 80%.Dislipidemia, e Hipertensão arterial sistólica, foram às doenças crônicas mais prevalentes. Mais de 50% dos idosos apresentaram alterações cognitivas e afetivas, e algum grau de dependência funcional. CONCLUSÃO: Esses resultados apontam para a complexidade do idoso no que se refere á sua condição de saúde, bem como, remete a necessidade de uma abordagem integral em saúde que reflita em melhora de sua qualidade de vida.

  6. Looks-Conscious Teens Trying Risky Supplements

    ... fullstory_159576.html Looks-Conscious Teens Trying Risky Supplements Unregulated products can harm health, U.S. pediatricians' group ... News) -- Many teens are turning to risky, unregulated supplements to boost their looks, warns a leading group ...

  7. Anthocyanin analyses of Vaccinium fruit dietary supplements

    Vaccinium fruit ingredients within dietary supplements were identified by comparisons with anthocyanin analyses of known Vaccinium profiles (demonstration of anthocyanin fingerprinting). Available Vaccinium supplements were purchased and analyzed; their anthocyanin profiles (based on HPLC separation...

  8. Kommentarer og supplement til DS 418

    Rode, Carsten; Saxhof, Bjarne

    1999-01-01

    Comments and Supplement for DS 418. Lecture note for DTU course 64040 Basic Course in Building Energy Technology.......Comments and Supplement for DS 418. Lecture note for DTU course 64040 Basic Course in Building Energy Technology....

  9. Muscle Mass and Weight Gain Nutritional Supplements

    Campbell, Bill

    There are numerous sports supplements available that claim to increase lean body mass. However, for these sports supplements to exert any favorable changes in lean body mass, they must influence those factors regulating skeletal muscle hypertrophy (i.e., satellite cell activity, gene transcription, protein translation). If a given sports supplement does favorably influence one of these regulatory factors, the result is a positive net protein balance (in which protein synthesis exceeds protein breakdown). Sports supplement categories aimed at eliciting a positive net protein balance include anabolic hormone enhancers, nutrient timing pre- and postexercise workout supplements, anticatabolic supplements, and nitric oxide boosters. Of all the sports supplements available, only a few have been subject to multiple clinical trials with repeated favorable outcomes relative to increasing lean body mass. This chapter focuses on these supplements and others that have a sound theoretical rationale in relation to increasing lean body mass.

  10. Iodine supplementation: benefits outweigh risks.

    Delange, F; Lecomte, P

    2000-02-01

    In 1990, iodine deficiency affected almost one-third of the world population and was the greatest single cause of preventable brain damage and mental retardation. Following a resolution adopted by the World Summit for Children in 1990. major programmes of iodine supplementation were implemented by the governments of the affected countries with the support of major donors. Iodisation of salt was recognised as the method of choice. Nine years later, by April 1999, 75% of the affected countries had legislation on salt iodisation and 68% of the affected populations had access to iodised salt. The prevalence of iodine deficiency disorders decreased drastically in most countries and the deficiency disappeared completely in some such as Peru. This result constitutes a public heath success unprecedented with a non-infectious disease. However, occasional adverse effects occurred. The principle effect is iodine-induced hyperthyroidism which occurs essentially in older people with autonomous nodular goitres, especially following iodine intake that is too rapid and of too massive an increment. The incidence of the disorder is usually low and reverts spontaneously to the background rate of hyperthyroidism or even below this rate after 1 to 10 years of iodine supplementation. The possible occurrence of iodine-induced thyroiditis in susceptible individuals has not been clearly demonstrated by large epidemiological surveys. Iodine supplementation is followed by an increased prevalence of occult papillary carcinoma of the thyroid discovered at autopsy but the prognosis of thyroid cancer is improved due to a shift towards differentiated forms of thyroid cancer that are diagnosed at earlier stages. Iodine-induced hyperthyroidism and other adverse effects can be almost entirely avoided by adequate and sustained quality control and monitoring of iodine supplementation which should also confirm adequate iodine intake. Available evidence clearly confirms that the benefits of correcting

  11. Direct Summands of ⊕-Supplemented Modules

    Nil Orhan; Derya Keskin Tütüncü; Rachid Tribak

    2007-01-01

    A module M is called ⊕-supplemented if every submodule of M has a supplement that is a direct summand of M. It is shown that if M is a ⊕-supplemented module and r(M) is a coclosed submodule of M for a left preradical r, then r(M) is a direct summand of M, and both r(M) and M/r(M) are ⊕-supplemented.

  12. Diffraction tomography of strain

    Lionheart, W R B; Withers, P. J.

    2015-01-01

    We consider whether it is possible to recover the three dimensional strain field tomographically from neutron and x-ray diffraction data for polycrystalline materials. We show that the distribution of strain transverse to a ray cannot be deduced from one diffraction pattern accumulated along that path, but that a certain moment of that data corresponds to the transverse ray transform of the strain tensor and so may be recovered by inverting that transform given sufficient data. We show that t...

  13. Strained Silicon Photonics

    Ralf B. Wehrspohn

    2012-05-01

    Full Text Available A review of recent progress in the field of strained silicon photonics is presented. The application of strain to waveguide and photonic crystal structures can be used to alter the linear and nonlinear optical properties of these devices. Here, methods for the fabrication of strained devices are summarized and recent examples of linear and nonlinear optical devices are discussed. Furthermore, the relation between strain and the enhancement of the second order nonlinear susceptibility is investigated, which may enable the construction of optically active photonic devices made of silicon.

  14. Strain-engineered MOSFETs

    Maiti, CK

    2012-01-01

    Currently strain engineering is the main technique used to enhance the performance of advanced silicon-based metal-oxide-semiconductor field-effect transistors (MOSFETs). Written from an engineering application standpoint, Strain-Engineered MOSFETs introduces promising strain techniques to fabricate strain-engineered MOSFETs and to methods to assess the applications of these techniques. The book provides the background and physical insight needed to understand new and future developments in the modeling and design of n- and p-MOSFETs at nanoscale. This book focuses on recent developments in st

  15. Incidência de delirium durante a internação em unidade de terapia intensiva em pacientes pré-tratados com estatinas no pós-operatório de cirurgia cardíaca

    Julia Niehues da Cruz

    2012-03-01

    Full Text Available OBJETIVO: Determinar a associação entre a administração pré-operatória de estatina e o delírium pós-operatório em uma corte prospectiva de pacientes submetidos à cirurgia cardíaca. MÉTODOS: Foram analisados pacientes adultos internados na unidade de terapia intensiva após cirurgia cardíaca entre janeiro e junho de 2011. A triagem para delirium foi realizada utilizando o Confusion Assessment Method para analisar delirium em uma unidade de terapia intensiva (CAM-ICU e Delirium Screening Checklist para terapia intensiva (ICDSC durante a internação na terapia intensiva RESULTADOS: Cento e sessenta e nove pacientes foram submetidos à cirurgia cardíaca eletiva, dos quais 40,2% estavam utilizando estatina no pré-operatório. Delirium foi identificado em 14,9% dos pacientes que não utilizavam estatina comparado com 11,8% dos que utilizavam (p=0,817 quando avaliados pelo CAM-ICU. Utilizando o ICDSC 18,8% dos pacientes que não usam estatina comparado com 10.3% dos que usam (p=0,191. CONCLUSÃO: Não há relação entre uso de estatinas com a ocorrência de delirium em pacientes submetidos a cirurgia cardíaca.

  16. Dietary supplementation practices of Singaporean athletes.

    Slater, Gary; Tan, Benedict; Teh, Kong Chuan

    2003-09-01

    The supplementation practices of elite athletes in Singapore were studied using an anonymous questionnaire. Information was sought on not only the type of supplements used but also dosage, rationale for use, and other factors that might influence supplement use including selected demographic parameters and sources of information relating to supplements. Data was collected from 160 athletes across a spectrum of 30 sports. Use of supplements was widespread, with 77% of respondents acknowledging use of at least 1 product. Respondents ingested a total of 59 different supplements, with each athlete using on average 3.6 +/- 0.3 different products. Sports drinks, caffeine, vitamin C, multivitamin/mineral supplements, and essence of chicken were some of the most commonly ingested products, confirming that while vitamin/mineral supplements are popular, sports supplements and traditional/herbal preparations were also well accepted. Respondents preferred to source information pertaining to supplements from "significant others" and other readily accessible sources. A small number of respondents acknowledged the use of International Olympic Committee (IOC) banned or restricted substances, highlighting the need for athletes to consult sports medicine professionals with specialist knowledge of dietary supplements in advance of initiating any supplementation regime. PMID:14669932

  17. 21 CFR 814.39 - PMA supplements.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false PMA supplements. 814.39 Section 814.39 Food and... PREMARKET APPROVAL OF MEDICAL DEVICES Premarket Approval Application (PMA) § 814.39 PMA supplements. Link to... shall submit a PMA supplement for review and approval by FDA before making a change affecting the...

  18. 47 CFR 61.86 - Supplements.

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Supplements. 61.86 Section 61.86... Rules for Tariff Publications of Dominant and Nondominant Carriers § 61.86 Supplements. A carrier may not file a supplement except to suspend or cancel a tariff publication, or to defer the effective...

  19. 22 CFR 71.12 - Dietary supplements.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Dietary supplements. 71.12 Section 71.12... Incarcerated Abroad § 71.12 Dietary supplements. (a) Eligibility criteria. A prisoner is considered eligible for the dietary supplement program under the following general criteria: (1) An evaluation by...

  20. 42 CFR 422.102 - Supplemental benefits.

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Supplemental benefits. 422.102 Section 422.102... (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Benefits and Beneficiary Protections § 422.102 Supplemental benefits. (a) Mandatory supplemental benefits. (1) Subject to CMS approval, an MA organization...

  1. IMPORTANCE OF NUTRITIONAL SUPPLEMENTS IN SPORT ACTIVITIES

    Gloria Sofia Margineantu

    2014-01-01

    The goals of sports performance cannot be reached only through training, but it includes also nutritional supplements along a proper diet. Especially in body shaping sports (fitness and bodybuilding) supplementation is a key factor contributing to the performance and compromise its failure often results. The right nutritional supplementation means not just what is consumed but when it is.

  2. 40 CFR 141.809 - Supplemental treatment.

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Supplemental treatment. 141.809... treatment. (a) Any supplemental drinking water treatment units installed onboard existing or new aircraft... the manufacturer's plans and specifications and FAA requirements. (b) Water supplemental treatment...

  3. Controle microbiológico em valvas cardíacas humanas Microbiologyc control in human heart valves

    Angela Maria Peruzzo

    2006-12-01

    Full Text Available OBJETIVO: Avaliar, sob o aspecto microbiológico, valvas processadas pelo Banco de Valvas Cardíacas Humanas da Irmandade da Santa Casa de Misericórdia de Curitiba, para serem utilizadas em cirurgias cardiovasculares. MÉTODOS: Foi avaliado o processamento de 1.671 valvas, no período de junho de 1999 a junho de 2004. Das valvas e soluções envolvidas no processo foram coletadas amostras e semeadas nos meios de cultura: meio líquido tioglicolato, caldo soja tripticaseína e caldo Sabouraud, com quatorze dias de incubação, utilizando a metodologia modificada baseada na Farmacopéia Brasileira 1998 e USP 1990 (United States Pharmacopeia. Nas amostras que apresentaram crescimento foram realizadas as identificações microbianas. RESULTADOS: Em um total de 1.671 amostras analisadas, 92% foram consideradas próprias para utilização, sob o aspecto microbiológico, uma vez que não apresentaram contaminação microbiana. Somente 8% não foram liberadas para uso clínico por motivo de contaminação em alguma etapa do processamento da valva. CONCLUSÃO: Analisando os resultados, observou-se a importância do controle microbiológico em enxertos humanos, evitando a utilização de valvas com contaminação microbiológica em pacientes submetidos à cirurgia cardiovascular.OBJECTIVE: To evaluate, from microbiological point of view, the valves processed by Human Heart Valve Bank of Santa Casa de Misericórdia of Curitiba for use in cardiovascular surgeries. METHODS: The processing of 1,671 valves, accomplished within the period of time between July 1999 and June 2004, was evaluated. Out of the valves and the solutions involved in the process, samples were collected and spread in culture mediums, such as fluid thioglycollate medium, tryptic soy broth and Sabouraud broth, for incubation during 14 days, using a modified methodology based on the Farmacopéia Brasileira 1988 (Brazilian Pharmacopeia and USP 1990 (United States Pharmacopeia. The samples in

  4. Avaliando a atividade vagal cardíaca na eletrocardiografia convencional Evaluating cardiac vagal activity on a conventional electrocardiogram

    Flávia P. Teixeira

    2007-04-01

    Full Text Available OBJETIVO: Determinar a viabilidade da utilização de traçado convencional de eletrocardiografia (ECG para avaliação da atividade vagal cardíaca (AVC. MÉTODOS: Foram analisados, retrospectivamente, 1.395 indivíduos (995 homens, na faixa de idade de 46 + 17,2 anos (média ± desvio padrão, com traçados de ECG convencional para medida do Delta RR, que representa a diferença, em ms, entre o maior e o menor intervalo RR, e com resultados da avaliação autonômica parassimpática, o teste de exercício de quatro segundos (T4s, que quantifica a AVC por meio do índice vagal cardíaco (IVC. Foram obtidas curvas ROC para determinar os valores de Delta RR com melhor relação entre sensibilidade e especificidade para os pontos de corte de baixa e alta AVC, respectivamente, de 1,20 e 1,95. RESULTADOS: Os valores de delta RR correlacionaram-se significativamente com os de IVC (r = 0,40; p 120 ms como os melhores pontos de corte para baixa e alta AVC, com sensibilidade de 75% e 57%, especificidade de 62% e 79% e áreas das curvas ROC de 0,76 e 0,74, respectivamente. CONCLUSÃO: A medida visual do delta RR em um traçado de ECG parece ser válida para a avaliação clínica preliminar e rápida da AVC, podendo ser útil em consultórios, emergências ou situações nas quais o uso de métodos mais sofisticados de avaliação autonômica não seja viável, oportuno ou conveniente.OBJECTIVE: To determine the viability of using a conventional electrocardiogram (ECG tracing for assessment of CVA. METHODS: We retrospectively analyzed 1395 individuals (995 males, aged 46 ± 17.2 years (mean ± standard deviation with conventional ECG tracings to measure the delta RR (which represents the difference in milliseconds (ms between the greatest and smallest RR interval and results of a second autonomic parasympathetic evaluation, the 4-second exercise test (T4s, that quantifies CVA by the cardiac vagal index (CVI. ROC curves were obtained to determine the

  5. Parada circulatória total em cirurgia cardíaca pediátrica: relato de 130 casos

    Hélcio GIFFHORN

    1998-01-01

    Full Text Available A hipotermia profunda com parada circulatória total (PCT apresentou um aumento importante nos pacientes operados em nosso Serviço e é de grande utilidade para a correção de alterações cardiovasculares complexas. Estudamos 130 pacientes de janeiro de 1995 a junho de 1996. A idade dos pacientes variou de 2 dias a 16 anos. As doenças mais freqüentes foram o defeito do septo ventricular (DSV (26%, tetralogia de Fallot (TF (13%, transposição das grandes artérias (TGA (10% e defeito do septo atrioventricular (DSAVT (10%. Em todos os pacientes foi usado o oxigenador de membranas, a temperatura retal em PCT foi mantida em média de 15°C. O tempo médio em perfusão foi de 45 minutos e o de PCT de 27 minutos. No pós-operatório imediato, a complicação mais freqüente foi a síndrome de baixo débito (49 casos - 38%. Alterações neurológicas ocorreram em 27 (20% pacientes: 13 (10% convulsões, 8 (6,1% disfunções neuropsicológicas, 5 (3,8% sinais extrapiramidais, 4 (3% déficits neurooftálmicos, 4 (3% comas. Cinco destes sintomas iniciaram precocemente no POI e podem ser atribuídos à PCT (3,8%. Ocorreram 20 (15% óbitos, 3 pacientes apresentaram déficit neurológico na alta hospitalar (2 disartrias - 1 hipertonia muscular. Concluímos que a hipotermia profunda com PCT é útil na correção de anomalias cardíacas complexas e que apresenta baixo risco de complicações neurológicas permanentes. O nosso seguimento tardio é pequeno para avaliar com precisão o desenvolvimento psicomotor dos pacientes.Deep hypothermic circulatory arrest (DHCA increased the number of pediatric patients operated on our Service and it is an important aid for the correction of complex cardiovascular procedures. We studied 130 patients from January, 1995 to June, 1996. Patient ages ranged from 2 days to 16 years. The most frequent pathology was VSD (26%, tetralogy of Fallot (13%, TGA (10% and AVSD (10%. All patients used membrane oxygenators, rectal

  6. Utilidad de un protocolo informatizado para el control estricto de la glucemia en pacientes sometidos a cirugía cardíaca

    Mariano Vrancic

    2008-01-01

    Full Text Available El control estricto de la glucemia durante el posoperatorio de cirugía cardíaca mejora la evolución de los pacientes, pero es de difícil implementación a pesar del uso de protocolos de manejo impresos.ObjetivoDeterminar si la utilización de un protocolo informatizado para el control estricto de la glucemia incrementa la adherencia del equipo de salud a las conductas sugeridas y mejora el control de la glucemia en pacientes sometidos a cirugía cardíaca.Material y métodosSe incluyeron 118 pacientes consecutivos intervenidos quirúrgicamente durante el último trimestre de 2005, en los cuales el control estricto de la glucemia se realizó mediante un protocolo de manejo impreso (grupo control, y 117 pacientes consecutivos del último trimestre de 2006, en los que se utilizó el mismo protocolo pero informatizado (grupo tratamiento.ResultadosEn concordancia con lo sugerido por los protocolos de manejo para un control estricto adecuado de la glucemia, los pacientes del grupo tratamiento tuvieron un tiempo menor a la primera medición de glucemia (60 RIC 40-65 versus 150 RIC 60-270 min; p < 0,001 y un número mayor de mediciones de glucemia (18 ± 6,6 versus 11 ± 6,4; p < 0,0001. Los pacientes del grupo tratamiento presentaron un porcentaje mayor de mediciones normoglucémicas (67% ± 18% versus 50% ± 25%; p < 0,0001 y un tiempo menor hasta el logro de la normoglucemia (165 RIC 105-280 versus 420 RIC 295-720 min; p < 0,001. ConclusiónEl empleo de un protocolo informatizado permite incrementar la adherencia del equipo de salud a las conductas sugeridas y mejorar el control de la glucemia en pacientes sometidos a cirugía cardíaca.

  7. Uso da radiofrequência bipolar para o tratamento da fibrilação atrial durante cirurgia cardíaca

    Leonardo Secchin Canale

    2011-06-01

    Full Text Available FUNDAMENTO: O tratamento da fibrilação atrial com dispositivo de ablação de tecidos por radiofrequência bipolar em concomitância à cirurgia cardíaca tem se mostrado método eficaz no tratamento desta arritmia. OBJETIVO: Descrever a experiência inicial do Instituto Nacional de Cardiologia no tratamento cirúrgico da fibrilação atrial com uso de dispositivo de radiofrequência bipolar em pacientes submetidos à cirurgia cardíaca, relatando o resultado de acompanhamento pós-operatório de um ano. MÉTODOS: Entre janeiro de 2008 e março de 2009, 47 pacientes (36 mulheres consecutivos, com idade média de 53,7 ± 10,6 anos, apresentando fibrilação atrial por um período médio de 34,6 meses (3 a 192 meses foram submetidos à ablação cirúrgica desta arritmia, por radiofrequência bipolar, durante o procedimento que motivou a indicação da cirurgia. Oito apresentavam fibrilação atrial intermitente e 39, contínua. Oitenta e um por cento foram submetidos à cirurgia valvar como procedimento principal. Esta é uma análise retrospectiva, observacional, com avaliação de um ano de pós-operatório das variáveis clínicas e de Holter 24 h. RESULTADOS: Dos 47 pacientes, 40 sobreviveram um ano. Desses, 33 foram submetidos a Holter 24 h, em um intervalo médio de 401 dias após a cirurgia. Encontrou-se a seguinte distribuição de ritmos: 24 (73% sinusal, 5 (15% fibrilação atrial, três (9% Flutter atrial e um (3% ritmo juncional. Foram observados dois acidentes vasculares encefálicos, sendo um associado à arritmia supraventricular. CONCLUSÃO: A ablação cirúrgica de fibrilação atrial com dispositivo de radiofrequência bipolar concomitante à cirurgia cardíaca é método eficaz para o tratamento desta arritmia.

  8. Papel dos níveis de BNP no prognóstico da insuficiência cardíaca avançada descompensada

    Antônio Carlos Pereira-Barretto

    2013-03-01

    Full Text Available FUNDAMENTO: A insuficiência cardíaca (IC é doença que cursa com má evolução, especialmente naqueles com IC avançada. A dosagem de peptídeo natriurético tipo B(BNP, ao lado da utilidade no diagnóstico da descompensação cardíaca, vem se mostrando útil na avaliação prognóstica. OBJETIVOS: Verificar se os níveis de BNP identificam quais pacientes evoluiriam pior e se o BNP seria fator independente de mortalidade considerando-se idade, sexo, funções cardíaca e renal e etiologia da cardiopatia. MÉTODOS: 189 pacientes com IC avançada em classe funcional III/IV foram estudados. Todos tinham disfunção sistólica e dosaram-se os níveis de BNP na hospitalização. Analisaram-se as variáveis relacionadas com a mortalidade através de análises univariada e multivariada. RESULTADOS: Os níveis de BNP foram mais elevados nos pacientes que morreram no primeiro ano de seguimento (1.861,9 versus 1.408,1 pg/dL; p = 0,044 e nos chagásicos (1.985 versus 1.452 pg/mL; p = 0,001, e esses pacientes chagásicos tiveram maior mortalidade no primeiro ano de seguimento (56% versus 35%; p = 0,010. Pela curva ROC, o valor de BNP de 1.400 pg/mL foi o melhor preditor de eventos, estando os valores elevados associados a FEVE mais baixa (0,23 versus 0,28; p = 0,002 e maior grau de disfunção renal (ureia média 92 versus 74,5 mg/dL; p = 0,002. CONCLUSÃO: Na IC avançada, os níveis elevados de BNP identificam pacientes com maior potencial de pior evolução. Os pacientes chagásicos apresentam níveis mais elevados de BNP do que as outras etiologias e têm pior evolução.

  9. Fibrilación auricular en el postoperatorio de cirugía cardíaca: Prevalencia y tiempo de internación

    Alejandro E. Contreras

    2010-08-01

    Full Text Available La fibrilación auricular es el trastorno del ritmo más frecuente luego de la cirugía cardíaca. En estudios previos se ha asociado a prolongación de la internación, aumento en los costos e incremento en la mortalidad. El objetivo de este estudio fue conocer la prevalencia de fibrilación auricular en el postoperatorio de cirugía cardíaca y determinar el efecto en el tiempo de estadía hospitalaria. Se analizaron retrospectivamente las historias clínicas de pacientes sometidos a cirugía cardíaca consecutivamente (de revascularización miocárdica, valvulares o ambas entre enero 2006 y noviembre 2008. El punto final evaluado en el postoperatorio fue la presencia de fibrilación auricular. Se dividió a la muestra en dos grupos según tuvieran o no fibrilación auricular, y se compararon las variables clínicas y el tiempo de estadía hospitalaria. Ciento setenta y dos pacientes fueron operados en este período. Se excluyeron del análisis siete pacientes por falta de datos. La edad media fue 64.2 ± 9.5 años, con predominio del sexo masculino. La fibrilación auricular fue la complicación más frecuente (23.6%. El tiempo promedio de internación fue 6.7 ± 4.6 días. No hubo diferencias relevantes al comparar la estadía hospitalaria entre los grupos con o sin fibrilación auricular, 7.5 ± 4.1 días vs. 6.5 ± 4.7 días respectivamente, p = 0.21. La presencia de fibrilación auricular no prolongó la hospitalización. Probablemente una estrategia de prevención indiscriminada no sería costo-efectiva.

  10. THE EFFECT OF DIFFERENT PROBIOTIC STRAINS ON FATTENINTHE EFFECT OF DIFFERENT PROBIOTIC STRAINS ON F

    Cyril Hrnčár

    2013-02-01

    Full Text Available The aim of this work was to verify the effect of different probiotic strains applied through a drinking water source to fattening and carcass parameters of broiler ducks. Fattening experiment was realised in half-operating conditions of experimental basis of Department of Poultry Science and Small Animal Husbandry in three-floor cage technology. Totally 90 broiler duck were divided to three groups. Experimental group 1 (n=30 received probiotic strain Lactobacillus fermentum CCM 7158 with concentration of 1x109 colony forming units (CFU in drinking water daily addition of 0.90 g day 1 to day 56 of fattening. Experimental group 2 (n=30 received probiotic strain Enterococcus faecium M 74 with concentration of 1x109 colony forming units (CFU in drinking water daily addition of 0.45 g day 1 to day 56 of fattening. The control group of birds (n=30 received water without any probiotics. The supplementation of probiotic strains Lactobacillus fermentum and Enterococcus faecium no significant affected (P≥0.05 final body weight, feed consumption and mortality of broiler ducks. From carcass parameters, we recorded statistically significant (P<0.05 reduction in weight of abdominal fat of broiler ducks for application of tested probiotic strains.

  11. Diagnósticos de enfermagem em pacientes no período pós-operatório de cirurgias cardíacas Diagnósticos de enfermería en pacientes en el período postoperatorio de cirugías cardíacas Nursing diagnoses in patients in the postoperative period of cardiac surgery

    Flávia Lamberti Pivoto

    2010-10-01

    Full Text Available OBJETIVO: Identificar, em conjunto com enfermeiras de uma Unidade de Tratamento Intensivo Pós-Operatória Cardiológica, diagnósticos de enfermagem presentes em pacientes no período pós-operatório de cirurgias cardíacas, com vistas à futura implementação do processo de enfermagem nessa unidade. MÉTODOS: Trata-se de um estudo qualitativo, ancorado na pesquisa convergente-assistencial. Os dados foram obtidos, nos registros de enfermagem de 20 pacientes submetidos à cirurgia cardíaca, no mês de abril de 2008, acrescidos da experiência profissional de seis enfermeiras participantes do grupo de convergência reunido durante cinco encontros. RESULTADOS: Foram estabelecidos 15 diagnósticos, segundo a Taxonomia II da North American Nursing Diagnosis Association, corroborados por outros autores. CONCLUSÃO: Identificar diagnósticos de enfermagem comuns em pacientes no pós-operatório de cirurgias cardíacas permite um direcionamento da assistência de enfermagem e subsidia o estabelecimento de intervenções fundamentadas e adequadas às necessidades individuais apresentadas por esses pacientes.OBJETIVO: Identificar en conjunto con las enfermeras, de una Unidad de Tratamiento Intensivo Postoperatorio Cardiológico, los diagnósticos de enfermería realizados en pacientes en el período postoperatorio de cirugías cardíacas, con la finalidad de, futuramente, implementar el proceso de enfermería en esa unidad. MÉTODOS: Se trata de un estudio cualitativo, basado en la investigación convergente-asistencial. Los datos fueron obtenidos de los registros de enfermería de 20 pacientes sometidos a cirugía cardíaca, en el mes de abril de 2008, acrecidos de la experiencia profesional de seis enfermeras participantes del grupo de convergencia que se reunió durante cinco encuentros. RESULTADOS: Fueron establecidos 15 diagnósticos, según la Taxonomía II de la North American Nursing Diagnosis Association, corroborados por otros autores

  12. Viability and growth characteristics of Lactobacillus in soymilk supplemented with B-vitamins.

    Ewe, Joo-Ann; Wan-Abdullah, Wan-Nadiah; Liong, Min-Tze

    2010-02-01

    Ten strains of Lactobacillus were evaluated for their viability in soymilk. Lactobacillus acidophilus ATCC 314, L. acidophilus FTDC 8833, L. acidophilus FTDC 8633 and L. gasseri FTDC 8131 displayed higher viability in soymilk and were thus selected to be evaluated for viability and growth characteristics in soymilk supplemented with B-vitamins. Pour plate analyses showed that the supplementation of all B-vitamins studied promoted the growth of lactobacilli to a viable count exceeding 7 log CFU/ml. alpha-Galactosidase specific activity of lactobacilli as determined spectrophotometrically showed an increase upon supplementation of B-vitamins. High-performance liquid chromatography analyses revealed that this led to increased hydrolysis of soy oligosaccharides and subsequently higher utilization of simple sugars. Production of organic acids as determined via high-performance liquid chromatography also showed an increase, accompanied by a decrease in pH of soymilk. Additionally, the supplementation of B-vitamins also promoted the synthesis of riboflavin and folic acid by lactobacilli in soymilk. Our results indicated that B-vitamin-supplemented soymilk is a good proliferation medium for strains of lactobacilli. PMID:19961357

  13. Health-related quality of life determinants in outpatients with heart failure Determinantes de la calidad de vida relacionada a la salud en pacientes atendidos en ambulatorios con insuficiencia cardíaca Determinantes da qualidade de vida relacionada à saúde em pacientes ambulatoriais com insuficiência cardíaca

    Viviane Martinelli Pelegrino

    2011-06-01

    Full Text Available This descriptive and exploratory study analyzed variables associated with health-related quality of life among 130 outpatients. Health-related quality of life was measured through the Minnesota Living with Heart Failure Questionnaire. Significant associations were found between patients’ health-related quality of life and their age (r=-0.177; p=0.044, vitality (r=-0.625; p=Trata-se de estudo descritivo e exploratório que analisou as variáveis associadas à qualidade de vida relacionada à saúde (QVRS, de 130 pacientes com insuficiência cardíaca, em seguimento ambulatorial. A QVRS foi avaliada pelo Minnesota Living with Heart Failure e realizada análise de regressão linear. A média da QVRS foi de 34,9 (dp=24,8; intervalo de 0 a 99. Foram encontradas associações significantes entre a medida da QVRS e idade (r=-0,177; p=0,044, vitalidade (r=-0,625; p=<0,001 e saúde mental (r=-0,672; p=<0,001, domínios do SF-36. A regressão linear mostrou que a gravidade dos sintomas da insuficiência cardíaca, e dois domínios do SF-36, vitalidade e saúde mental, explicaram 54% da variação da medida da QVRS. Controlar os sintomas e manter bem-estar mental é essencial para a manutenção da QVRS e são essenciais para o cuidado eficaz da insuficiência cardíaca.

  14. Characterization of a Trypanosoma rangeli Strain of Colombian Origin

    Zuñiga C

    1997-01-01

    Full Text Available A Colombian strain of Trypanosoma rangeli was characterized by analyzing its behaviour in different axenic and cellular culture, its infection rate and the histopathological lesions produced in experimental animals. Although slight inflammatory infiltrations were shown in different histopathological sections, no pseudocysts could be observed. Grace's insect medium is better than liver infusion tryptose or artificial triatomine urine supplemented with proline when studying T. rangeli metacyclogenesis, with a peak of 32% trypomastigotes. High infection rates were found in VERO and J774 cells. Because of its 100% infectivity rates and adequacy of parasitemia levels, C23 strain is a suitable model of T. rangeli biology study

  15. Weakly Distributive Modules. Applications to Supplement Submodules

    Engin Büyükaşik; Yilmaz M Demirci

    2010-11-01

    In this paper, we define and study weakly distributive modules as a proper generalization of distributive modules. We prove that, weakly distributive supplemented modules are amply supplemented. In a weakly distributive supplemented module every submodule has a unique coclosure. This generalizes a result of Ganesan and Vanaja. We prove that -projective duo modules, in particular commutative rings, are weakly distributive. Using this result we obtain that in a commutative ring supplements are unique. This generalizes a result of Camillo and Lima. We also prove that any weakly distributive $\\oplus$-supplemented module is quasi-discrete.

  16. O impacto do CPAP na reabilitação cardíaca de pacientes com ICC: relato de caso El impacto del CPAP en la rehabilitación cardíaca de pacientes con ICC: caso clínico The impact of continuous positive airway pressure (CPAP on the cardiac rehabilitation of patients with congestive heart failure: case report

    Murillo Frazão de Lima e Costa

    2010-07-01

    Full Text Available A insuficiência cardíaca congestiva é uma patologia que limita a função física do paciente. Neste estudo foi analisada uma paciente, realizando um programa de reabilitação cardíaca associado à pressão positiva contínua nas vias aéreas, aferindo-se antes do estudo e após 6 semanas, o teste de caminhada de 6 minutos (TC6M, questionário de qualidade de vida e ecocardiograma. A paciente aumentou a distância no TC6M de 152,5 m para 520,44 m. O questionário Minnesota reduziu de 62 para 18. A fração de ejeção subiu de 33% para 36%. Na paciente estudada a conduta melhorou o desempenho físico e a qualidade de vida.La insuficiencia cardíaca congestiva es una patología que limita la función física del paciente. En este estudio fue analizada una paciente, realizando un programa de rehabilitación cardíaca asociado a la presión positiva continua en las vías aéreas, realizando antes del estudio y después de 6 semanas, el test de caminata de 6 minutos (TC6M, cuestionario de calidad de vida y ecocardiograma. La paciente aumentó la distancia en el TC6M de 152,5 m a 520,44 m. El cuestionario Minnesota redujo de 62 a 18. La fracción de eyección subió de 33% a 36%. En la paciente estudiada la conducta mejoró el desempeño físico y la calidad de vida.Congestive heart failure is a pathology that limits the patient's physical function. This study analyzed one patient who was submitted to a cardiac rehabilitation program associated to Continuous Positive Airway Pressure (CPAP, by assessing the results of the six-minute walk test (6MWT and a questionnaire on the quality of life and performing an echocardiographic assessment before the study and after six weeks. The distance walked by the patient increased from 152.5 m to 520.44 m at the 6MWT. The Minnesota questionnaire score decreased from 62 to 18. Ejection fraction increased from 33% to 36%. Therefore, the management chosen for this case improved the patient's physical performance

  17. Highly Strained Organophosphorus Compounds

    Slootweg, J.C.

    2005-01-01

    In our research on small, strained organophosphorus ring systems we became interested in the synthesis and applications of species that are even more strained than the parent phosphirane, by introducing an exocyclic double bond (methylenephosphirane), and by cyclopropyl spirofusion to the edge (e.g

  18. Particle Suspension Mechanisms - Supplemental Material

    Dillon, M B

    2011-03-03

    This supplemental material provides a brief introduction to particle suspension mechanisms that cause exfoliated skin cells to become and remain airborne. The material presented here provides additional context to the primary manuscript and serves as background for designing possible future studies to assess the impact of skin cells as a source of infectious aerosols. This introduction is not intended to be comprehensive and interested readers are encouraged to consult the references cited.

  19. Synthetic Androgens as Designer Supplements

    Joseph, Jan Felix; Parr, Maria Kristina

    2015-01-01

    Anabolic androgenic steroids (AAS) are some of the most common performance enhancing drugs (PED) among society. Despite the broad spectrum of adverse effects and legal consequences, AAS are illicitly marketed and distributed in many countries. To circumvent existing laws, the chemical structure of AAS is modified and these designer steroids are sold as nutritional supplements mainly over the Internet. Several side effects are linked with AAS abuse. Only little is known about the pharmacologic...

  20. Dietary Supplements in Multiple Sclerosis

    Alajbegović, A.; Alajbegović, S.; Đelilović-Vranić, J

    2011-01-01

    Replacement therapy is a treatment that is not based on accepted medical knowledge and science that is not in accordance with current medical doctrine. Additional treatment is not contrary to the accepted doctrine of medical schools, but serves only as a supplement to the accepted treatment. Most general practitioners in England and Germany do not contradict these forms of treatment. On average 2/3 of patients with MS in the course of the disease try alternate options and additional tre...

  1. Pseudomonas chlororaphis Strain Sm3, Bacterial Antagonist of Pratylenchus penetrans

    Hackenberg, Clemens; Muehlkchen, Andrea; Forge, Thomas; Vrain, Thierry

    2000-01-01

    The interaction of Pseudomonas chlororaphis strain Sm3 and the root-lesion nematode Pratylenchus penetrans was investigated in three separate greenhouse experiments with soils from southern British Columbia, Canada. The bacteria were applied to the roots of strawberry plants and planted in unpasteurized field soils, with natural or supplemented infestation of P. penetrans. Nematode suppression in roots was evident after 6 or 10 weeks in all experiments. Root or shoot growth were increased aft...

  2. Supplement Use of Elite Australian Swimmers.

    Shaw, Gregory; Slater, Gary; Burke, Louise M

    2016-06-01

    This study examined the influence the Australian Institute of Sport (AIS) Sport Supplement Program had on supplement practices of elite Australian swimmers, comparing those guided by the Program with others in the same national team. Thirty-nine elite swimmers (13 AIS, 26 Other; 20 female, 19 male; age 21.8 ± 3.3 y) completed a questionnaire investigating supplement use. Ninety-seven percent of swimmers reported taking supplements or sports foods over the preceding 12 months. AIS swimmers reported using more total brands (p = .02) and supplements considered Ergogenic (p = .001) than Other swimmers who used more supplements considered to be lacking scientific support (p = .028). Swimmers rated the risk of a negative outcome from the use of supplements available in Australia (Mdn = 3.0) as less than the risk of supplements from international sources (Mdn = 4.0; p dietary supplements from supermarkets. These findings suggest that swimmers influenced by this sport supplement program more frequently use supplements that are recommended by allied health trained individuals, classified as evidence based and provided by the program. PMID:26630501

  3. Nous reptes en la insuficiència cardíaca crònica: Comorbiditats emergents i objectius centrats en el pacient

    Comín Colet, Josep

    2012-01-01

    La insuficiència cardíaca crònica (ICC) s’ha convertit en un autèntic repte per al sistemes de salut degut a la seva alta prevalença, alta mortalitat i elevats costos econòmics associats. En els pacients amb ICC de base comunitària la comorbiditat és la norma i en molts d’ells, la millora de la qualitat de vida és un objectiu d’ eficàcia equiparable als objectius clàssics dels assajos clínics. La recerca moderna en aquesta síndrome ha de donar resposta terapèutica a comorbiditats emergents en...

  4. Expression, purification, crystallization and preliminary X-ray analysis of calmodulin in complex with the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8

    Tidow, Henning; Hein, Kim Langmach; Bækgaard, Lone;

    2010-01-01

    of calcium-bound calmodulin (Ca(2+)-CaM) to this tail and a conformational change that displaces the autoinhibitory tail from the catalytic domain. The complex between calmodulin and the regulatory domain of the plasma-membrane Ca(2+)-ATPase ACA8 from Arabidopsis thaliana has been crystallized. The......Plasma-membrane Ca(2+)-ATPases (PMCAs) are calcium pumps that expel Ca(2+) from eukaryotic cells to maintain overall Ca(2+) homoeostasis and to provide local control of intracellular Ca(2+) signalling. They are of major physiological importance, with different isoforms being essential, for example...... crystals belonged to space group C2, with unit-cell parameters a = 176.8, b = 70.0, c = 69.8 A, beta = 113.2 degrees. A complete data set was collected to 3.0 A resolution and structure determination is in progress in order to elucidate the mechanism of PMCA activation by calmodulin....

  5. Avaliação do conhecimento de pacientes de reabilitação cardíaca: Brasil versus Canadá

    2013-01-01

    FUNDAMENTO: Grande parte da relação entre o estado de saúde e o conhecimento sobre saúde e doença pode ser atribuída aos efeitos combinados de comportamento dísparrelacionado à saúde, condições ambientais e estruturas socioeconômicas, bem como o contato com a atenção à saúde e prestação da mesma. OBJETIVO: O objetivo do presente estudo foi descrever e comparar o conhecimento dos pacientes com doença arterial coronariana (DAC),incluídos em programas de reabilitação cardíaca (RC) no Brasil e no...

  6. Avaliação da intensidade de dor e sinais vitais no pós-operatório de cirurgia cardíaca

    Adriana de Fátima Alencar Miranda; Lúcia de Fátima da Silva; Joselany Áfio Caetano; Ana Cláudia de Sousa; Paulo César de Almeida

    2011-01-01

    O objetivo do estudo é analisar as alterações nos sinais vitais de pacientes em pós-operatório de cirurgias cardíacas, mediante intensidade de dor referida. Trata-se de estudo descritivo-exploratório, que utilizou o método de análise quantitativa na investigação de 38 pacientes submetidos à primeira renovação de curativos. A análise dos dados, mensurados antes e após a realização do procedimento de enfermagem, indicaram que a manifestação da dor ocorreu em diferentes classificações. As princi...

  7. Estetoscópio digital como ferramenta inovadora no ensino da ausculta cardíaca Digital stethoscope as an innovative tool on the teaching of auscultatory skills

    Claudio Tinoco Mesquita

    2013-02-01

    Full Text Available O exame físico cardiovascular, em particular a ausculta cardíaca, é uma das habilidades clínicas mais difíceis para os alunos durante seu treinamento médico. Estudos sugerem que o uso de tecnologias, como o estetoscópio digital, aumente a acurácia do exame clínico, entretanto, seu impacto no ensino da propedêutica da ausculta cardíaca em alunos de graduação de Medicina não é conhecido. O objetivo é demonstrar a utilidade do estetoscópio digital, em comparação com métodos tradicionais, como instrumento de ensino da ausculta cardíaca. Estudo de intervenção, longitudinal, controlado, unicêntrico e randomizado. Foram inscritos 38 alunos de medicina para um curso de semiologia cardiovascular com duração de oito semanas. Definiu-se um programa com aulas expositivas e à beira do leito nas enfermarias de Cardiologia. Nas aulas práticas, os alunos foram randomizados em dois grupos: 1 (n = 21 estetoscópio digital (Littmann® modelo 3200, 3M; e 2 (n = 17 estetoscópios convencionais. Foi realizada uma avaliação pré-treinamento, através de um teste utilizando o software Heart Sounds®, que foi repetida ao final do curso. As médias das avaliações foram comparadas pelo teste T pareado e não pareado. Observa-se que, ao final do curso, houve uma melhora significativamente maior no grupo que utilizou o estetoscópio digital (51,9% quando comparado ao grupo que utilizou o estetoscópio convencional (29,5%. Intervenções de curta duração para o ensino de semiologia cardíaca são capazes de contribuir de modo significativo para melhora da proficiência da identificação dos sons cardíacos. O uso do estetoscópio digital demonstrou ser um fator positivo no ensino dessas habilidades.Physical cardiovascular examination, particularly cardiac auscultation, is one of the most difficult clinical skills for students during their medical training. Studies suggest that the use of technologies such as digital stethoscope increase the

  8. Cuidados imediatos no pós-operatório de cirurgia cardíaca Immediate post-operative care following cardiac surgery

    Paulo Ramos David João

    2003-11-01

    Full Text Available OBJETIVO: Apresentar uma rotina de atendimento para crianças submetidas à cirurgia cardíaca. FONTES DOS DADOS: Realizada revisão bibliográfica através de bancos de dados (Medline, Mdconsult, PubMed, analisando as condutas sugeridas por diversos serviços fora do Brasil e comparando com a rotina de atendimento no Hospital Infantil Pequeno Príncipe, de Curitiba, onde foram realizadas cerca de 8.000 cirurgias cardíacas desde 1977 até abril de 2003. SÍNTESE DOS DADOS: O serviço citado é referência em cardiologia e cirurgia cardíaca no estado do Paraná e estados vizinhos. A evolução das condições de diagnóstico, preparo da equipe clínica e cirúrgica, unidade de terapia intensiva (UTI melhor equipada com monitorização mais avançada, equipe da UTI com pessoal treinado em todas as áreas para fazer pós-operatório de cirurgia cardíaca, estrutura hospitalar adequada, oferecendo atendimento avançado em todas as especialidades pediátricas e paramédicas, fazem com que o resultado das intervenções cirúrgicas realizadas em crianças com cardiopatias congênitas ou adquiridas, principalmente nos recém-nascidos e lactentes jovens com cardiopatias complexas, apresente sensível melhora quando comparado com anos anteriores. CONCLUSÃO: As crianças com cardiopatias, principalmente as complexas, devem ser encaminhadas para um local que seja centro de referência, onde haja condições para um atendimento global no pré, per e pós-operatório.OBJECTIVE: To present a care routine for children submitted to heart surgery. SOURCE OF DATA: Literature review of Medscape, MD Consult and PubMed. Analysis of the suggested conducts adopted by various services from different countries and comparison with the care routine at the Pequeno Príncipe Children's Hospital (Curitiba, state of Paraná, where approximately 8,000 heart surgeries were performed in children from 1977 to April 2003. SUMMARY OF THE FINDINGS: Our hospital is a reference

  9. El Sulfato de Magnesio prepinzamiento aórtico como preservador energético en cirugía cardíaca

    Santos Gracia, José Juan

    2003-01-01

    Hay evidencia de un déficit crónico de magnesio en la población mundial atribuido a ingestión deficitaria. En los cardiópatas, la utilización de drogas depletoras agrava este déficit y contribuye a la aparición de arritmias malignas. El magnesio ha sido recomendado en el tratamiento del Infarto Agudo del Miocardio por preservar la energía de la célula cardíaca isquémica o reperfundida desde la era “pretrombolítica” y en todas las variantes de arritmias. Sin embargo, su utilización en cardioci...

  10. Infarto de miocardio, infarto social. La experiencia de las restricciones en un programa de rehabilitación cardíaca

    Arenas Paños, Miquel

    2016-01-01

    La investigació aprofundeix en l’experiència de les persones que han patit un infart agut de miocardi i després, en el marc de la prevenció secundària de la cardiopatia isquèmica, segueixen un programa de rehabilitació cardíaca on les seves pràctiques es veuen qüestionades per les recomanacions d’educació sanitària rebudes al programa. El menjar, l’activitat, física, el tabaquisme o l’estrès adquireixen nous significats quan la nova normativa qüestiona el passat i projecta incertesa i vulner...

  11. Acupuntura na assistência de enfermagem ao paciente portador de arritmias cardíacas: pesquisa bibliográfica

    Márcio Rogério Bertuga

    2012-06-01

    Full Text Available Introdução: Entre as patologias cardíacas, parte dos eventos está relacionada com as arritmias. Inúmeros tratamentos são encontrados; medicamentosos e cirúrgicos; que nem sempre apresentam resultados satisfatórios, com uso de drogas que provocam reações adversas significativas e, a busca pela adequação da dosagem causa grande desconforto. As cirurgias são onerosas e nem sempre acessíveis aos sofredores de arritmias. Atualmente, busca-se por tratamentos alternativos, entre os quais, a Acupuntura, técnica da Medicina Tradicional Chinesa (MTC sobressai às outras pela grande divulgação midiática. São conhecidos dos Acupunturistas seus benefícios no que tange as doenças cardíacas e, em especial, as arritmias. Objetivo: Buscar subsídios para o uso da Acupuntura como técnica efetiva usada pelo Enfermeiro na assistência do paciente cardiopata. Metodologia: Pesquisa bibliográfica realizada com consulta de livros, uma vez que a busca por trabalhos na Biblioteca Virtual de Saúde – BVS, utilizando as bases de dados LILACS, IBECS E MEDLINE, com as palavras-chave acupuntura e enfermagem, cardiologia e acupuntura e enfermagem e cardiologia não apresentou resultados que sustentem a possibilidade da ocorrência e prática dos pressupostos afirmados no corpo do projeto. Resultados: A Acupuntura é técnica da MTC, nesta as patologias são explicadas por concepções energéticas de saúde e fisiologia. Na MTC, o coração regula o sangue e os vasos sanguíneos, e armazena a consciência. É patente que as disfunções cardíacas acarretam prejuízo à totalidade do organismo, em órgão salvos e ao estado de consciência, daí a preocupação com as síndromes energéticas, pois são a origem dos distúrbios cardiocirculatórios. Por esse olhar, os padrões de desarmonia do coração podem ser divididos em dois grupos: Deficiência de Yang e deficiência de Yin e suas síndromes. Foram selecionados 35 livros, entre estes, 19 espec

  12. Plate-forme Magicien d'Oz pour l'\\'etude de l'apport des ACAs \\`a l'interaction

    Simonin, Jérôme; Carbonell, Noëlle

    2007-01-01

    In order to evaluate the contribution of Embodied (Animated) Conversational Agents (ECAs) to the effectiveness and usability of human-computer interaction, we developed a software platform meant to collect usage data. This platform, which implements the wizard of Oz paradigm, makes it possible to simulate user interfaces integrating ACAs for any Windows software application. It can also save and "replay" a rich interaction trace including user and system events, screen captures, users' speech and eye fixations. This platform has been used to assess users' subjective judgements and reactions to a multimodal online help system meant to facilitate the use of software for the general public (Flash). The online help system is embodied using a 3D talking head (developed by FT R&D) which "says" oral help messages illustrated with Flash screen copies.

  13. Optimization of immobilization technology conditions for GL-7-ACA acylase%GL-7-ACA酰化酶的固定化工艺条件优化

    郭璐; 黎继烈; 王卫; 罗倩; 朱晓媛

    2013-01-01

    采用单因素和Box-Behnken实验对LX-1000EP树脂固定化戊二酰-7-氨基头孢烷酸酰化酶的工艺条件进行优化.首先通过单因素设计研究载体用量、缓冲液pH值、时间、温度四个因素对固定化戊二酰-7-氨基头孢烷酸酰化酶活力的影响,在此基础上,利用响应面试验设计对LX-1000EP树脂固定化戊二酰-7-氨基头孢烷酸酰化酶的条件进行优化.载体用量、缓冲液pH值、时间、温度对固定化戊二酰-7-氨基头孢烷酸酰化酶都有影响,固定化最佳工艺条件为:载体用量3.3 g、pH值7.9、时间40 h、温度25℃,在此条件下固定化酶活力达到(69.5±0.8) U/g,酶活回收率达到42.41%.将响应面法应用于固定化戊二酰-7-氨基头孢烷酸酰化酶条件的优化是可行的.%The immobilization technology conditions of GL-7-ACA acylase with LX-1000EP resin were optimized by using single factor analytical methodology and Box-Behnken experimental design.Firstly,the effects of carrier dosage,buffer solution pH,time and temperature on the vitality of GL-7-ACA acylase were investigated by adopting single factor design,based on which,the immobilization conditions were optimized by response surface methodology.The results show that the four factors all had effects on immobilized GL-7-ACA acylase activity,and the optimal immobilization conditions are as follows:3.3 of the carrier dosage,pH 7.9,time 40 hours and temperature 25 ℃.Under these appropriate conditions above,the immobilized enzyme,s activity was 69.5 ± 0.8U/g,the activity recovery was 42.41%.So it is feasible to optimize the immobilization conditions of GL-7-ACA acylase with LX-1000EP by using response surface methodology.

  14. Insuficiência cardíaca de alto débito devida a fístula coronária

    Petrucci Jr Orlando; Oliveira Pedro Paulo M. de; Leme Jr Cid de Abreu; Coelho Otávio Rizzi; Schellini Fernando A. Barca; Nogueira Eduardo Arantes; Vieira Reinaldo W.; Braile Domingo Marcolino

    1998-01-01

    Em mulher de 45 anos, apresentando quadro de insuficiência cardíaca classe funcional III e dor torácica atípica, foi evidenciada dilatação importante da coronária direita e sua drenagem para o átrio direito, demonstrada na ecocardiografia transtorácica e confirmada pela angiografia coronária. A paciente foi submetida a cirurgia, encontrando-se um ramo único desembocando no átrio direito, que foi ligado. Sua evolução pós-operatória foi boa estando, há três anos, livre de qualquer sintomatologi...

  15. O trabalho da enfermagem no pós-operatório de cirurgia cardíaca: uma revisão integrativa

    Ana Paula Azevedo Santos; Ana Maria Laus; Silvia Helena Henriques Camelo

    2015-01-01

    Este estudo teve o objetivo de identificar, por meio de produções científicas nacionais e internacionais, os cuidados desenvolvidos pela equipe de enfermagem durante a assistência ao paciente no pósoperatório de cirurgia cardíaca. Trata-se de uma revisão integrativa realizada por meio de busca às bases PubMed, LILACS, CINAHL, SCOPUS e BDENF no período de fevereiro a junho de 2014, com o seguinte questionamento: “Quais os cuidados realizados pela equipe de enfermagem ao paciente no pós-operató...

  16. Estudo da reprodutibilidade da frequência cardíaca e perceção subjetiva do esforço no Power Jump

    Macêdo, Idamélia Oliota Ribeiro de

    2016-01-01

    Dissertação de Mestrado em Ciências do Desporto, Especialização em Avaliação e Prescrição nas Atividades Físicas Desportivas A procura pela prática de exercícios físicos em academias tem crescido a cada dia em busca da estética e saúde. Os programas em academia de ginástica têm oferecido diferentes metodologias inovadoras como forma de estratégia na motivação e adesão dos seus praticantes. O objetivo deste estudo foi Investigar a reprodutibilidade da frequência cardíaca (FC) e perceção sub...

  17. Lesões de pele no intra-operatório de cirurgia cardíaca: incidência e caracterização

    Geisa Aguiari Carneiro

    2011-06-01

    Full Text Available Neste estudo exploratório, descritivo e de coorte o objetivo principal foi verificar a incidência de pacientes submetidos à cirurgia cardíaca que desenvolveram lesões de pele no período intra-operatório, caracterizar as lesões. A coleta de dados foi realizada no Centro Cirúrgico (CC de um hospital público de ensino, de atenção terciária à saúde, predominantemente cirúrgico, especializado em cardiologia no Município de São Paulo. A amostra do estudo foi de 182 pacientes. O estudo foi feito com um p significativo (<0,05 frente aos testes estatísticos não-paramétricos. Quanto à incidência de pacientes submetidos à cirurgia cardíaca, que desenvolveram lesões de pele em decorrência do período intra-operatório, obteve-se incidência de 20,9%. Tivemos que 19,2% das lesões apresentaram-se como Úlceras por Pressão (UP no estágio I; 1,1% das lesões caracterizaram-se como abrasão; 1,1% feridas incisas; 0,5% laceração; 0,5% queimadura elétrica superficial e 0,5% UP no estágio II.

  18. El aumento del riesgo de mortalidad en la cirugía cardíaca. ¿Realmente estamos operando pacientes con incremento del riesgo?

    Raúl A. Borracci

    2006-01-01

    Full Text Available Aunque varios estudios parecen demostrar el aumento en el tiempo del riesgo quirúrgico de los candidatos a cirugía cardíaca, la mayoría de las comunicaciones se basan en su incremento promedio, sin analizar la verdadera distribución por grupos de riesgo. Con el objetivo de evaluar si en la actualidad existe un aumento del riesgo de mortalidad en la cirugía cardíaca en nuestro medio respecto del riesgo de una década atrás, basándonos no sólo en la variación promedio, sino también en la distribución de dichos riesgos, se compararon en forma retrospectiva las distribuciones relativas de los riesgos de mortalidad con el puntaje ( score de Parsonnet en dos series de cirugías: 464 operados entre 1993 y 1995 versus 502 intervenidos entre 2004 y 2005. La distribución de frecuencias relativas mostró que en el período 2004-2005 creció la proporción de pacientes con riesgo más alto (8% a 13%; p < 0,05 y, paradójicamente, también se incrementó el porcentaje de operados dentro del grupo con el menor riesgo (18% a 28%; p < 0,05, lo cual llevó a que el puntaje de riesgo promedio no aumentara significativamente ( 8,2 a 9,2; p = ns.

  19. Sprains and Strains

    ... people at risk for strains. Gymnastics, tennis, rowing, golf, and other sports that require extensive gripping can ... Trials and You was designed to help people learn more about clinical trials, why they matter, and ...

  20. The strained state cosmology

    Tartaglia, Angelo

    2015-01-01

    Starting from some relevant facts concerning the behaviour of the universe over large scale and time span, the analogy between the geometric approach of General Relativ- ity and the classical description of an elastic strained material continuum is discussed. Extending the elastic deformation approach to four dimensions it is shown that the accelerated expansion of the universe is recovered. The strain field of space-time repro- duces properties similar to the ones ascribed to the dark energy currently called in to explain the accelerated expansion. The strain field in the primordial universe behaves as radiation, but asymptotically it reproduces the cosmological constant. Subjecting the theory to a number of cosmological tests confirms the soundness of the approach and gives an optimal value for the one parameter of the model, i.e. the bulk modulus of the space-time continuum. Finally various aspects of the Strained State Cosmology (SSC) are discussed and contrasted with some non-linear massive gravity theor...

  1. Reduction in squamous cell carcinomas in mouse skin by dietary zinc supplementation.

    Sun, Jin; Shen, Rulong; Schrock, Morgan S; Liu, James; Pan, Xueliang; Quimby, Donald; Zanesi, Nicola; Druck, Teresa; Fong, Louise Y; Huebner, Kay

    2016-08-01

    Inadequate dietary Zn consumption increases susceptibility to esophageal and other cancers in humans and model organisms. Since Zn supplementation can prevent cancers in rodent squamous cell carcinoma (SCC) models, we were interested in determining if it could have a preventive effect in a rodent skin cancer model, as a preclinical basis for considering a role for Zn in prevention of human nonmelanoma skin cancers, the most frequent cancers in humans. We used the 7,12-dimethyl benzanthracene carcinogen/phorbol myristate acetate tumor promoter treatment method to induce skin tumors in Zn-sufficient wild-type and Fhit (human or mouse protein) knockout mice. Fhit protein expression is lost in >50% of human cancers, including skin SCCs, and Fhit-deficient mice show increased sensitivity to carcinogen induction of tumors. We hypothesized that: (1) the skin cancer burdens would be reduced by Zn supplementation; (2) Fhit(-/-) (Fhit, murine fragile histidine triad gene) mice would show increased susceptibility to skin tumor induction versus wild-type mice. 30 weeks after initiating treatment, the tumor burden was increased ~2-fold in Fhit(-/-) versus wild-type mice (16.2 versus 7.6 tumors, P < 0.001); Zn supplementation significantly reduced tumor burdens in Fhit(-/-) mice (males and females combined, 16.2 unsupplemented versus 10.3 supplemented, P = 0.001). Most importantly, the SCC burden was reduced after Zn supplementation in both strains and genders of mice, most significantly in the wild-type males (P = 0.035). Although the mechanism(s) of action of Zn supplementation in skin tumor prevention is not known in detail, the Zn-supplemented tumors showed evidence of reduced DNA damage and some cohorts showed reduced inflammation scores. The results suggest that mild Zn supplementation should be tested for prevention of skin cancer in high-risk human cohorts. PMID:27185213

  2. An Ultrasonic Strain Gauge

    Kersemans, Mathias; Allaer, Klaas; Degrieck, Joris; Van Den Abeele, Koen; Pyl, Lincy; Zastavnik, Filip; Sol, Hugo; Van Paegem, Wim

    2014-01-01

    A method is introduced for the measurements of strain exploiting the interaction between ultrasound waves and characteristics of the insonified specimen. First, the response of obliquely incident harmonic waves to a deterministic surface roughness is utilized. Analysis of backscattered amplitudes in Bragg diffraction geometry then yields a measure for the in-plane strain field by mapping any shift in angular dependency. Secondly, the analysis of the reflection characteristics of normal incide...

  3. Iodine Supplementation in the Newborn

    Paolo Ghirri

    2014-01-01

    Full Text Available Iodine deficiency can be defined as the world’s greatest single cause of preventable brain damage. Fetal and neonatal hypothyroidism, caused by iodine deficiency can be prevented prior to conception and then during pregnancy and lactation when an adequate iodine supplementation is ensured. Extremely low birth weight preterm babies risk having a negative iodine balance status in the first weeks of life, exacerbating the hypothyroxinaemia of the prematurity. It is important to ensure that these babies are provided with an adequate iodine intake from the first days of life. Mothers and newborns should avoid environmental iodine excess during pregnancy or lactation.

  4. Nutritional Supplements to Enhance Recovery

    Ziegenfuss, Tim N.; Landis, Jamie; Greenwood, Mike

    The ability to recover from intense exercise often separates good athletes from great ones. In the past, "recovery" often simply included rest, physical modalities (e.g., massage, hydration therapy) and meeting basic nutritional needs for fluid and energy intake. Today, athletes have a number of additional options to help them recover from high intensity training, one of which includes the judicious use of dietary supplements. This chapter briefly reviews nutritional strategies that have a strong theoretical background for enhancing rehydration/electrolyte balance, replenishing energy reserves, minimizing oxidative damage, and stimulating muscle repair.

  5. Activity of lysozyme on Lactobacillus hilgardii strains isolated from Port wine

    Dias, Rita; Vilas-Boas, Eduardo; Campos, Francisco; Hogg, Tim; Couto, José António

    2015-01-01

    This work evaluated the effect of lysozyme on lactobacilli isolated from Port wine. Bacterial growth experiments were conducted in MRS/TJ medium and inactivation studies were performed in phosphate buffer (KH2PO4), distilled water and wine supplemented with different concentrations of lysozyme. The response of bacteria to lysozyme was found to be highly strain dependent. Some strains of Lactobacillus hilgardii together with Lactobacillus collinoides and Lactobacillus fructivorans ...

  6. Fermentative capability and aroma compound production by yeast strains isolated from Agave tequilana Weber juice

    Diaz-Montano, Dulce Maria; Délia, Marie-Line; Estarron-Espinosa, Mirna; Strehaiano, Pierre

    2008-01-01

    Five yeast strains isolated from agave juice were studied for their fermentative and aromatic capacity. The experiments were performed using agave juice supplemented with ammonium sulphate, as is commonly done in tequila distilleries. Three strains classified as Saccharomyces cerevisiae showed high biomass and ethanol production, as well as higher ethanol tolerance than those classified as Kloeckera africana and Kloeckera apiculata, which showed scarce growth. The results suggest that Kloecke...

  7. Biosynthesis of poly(3-hydroxypropionate) from glycerol using engineered Klebsiella pneumoniae strain without vitamin B12

    Feng, Xinjun; Xian, Mo; Liu, Wei; Xu, Chao; Zhang, Haibo; Zhao, Guang

    2015-01-01

    Poly(3-hydroxypropionate) (P3HP) is a biodegradable and biocompatible thermoplastic. Previous studies demonstrated that engineered Escherichia coli strains can produce P3HP with supplementation of expensive vitamin B12. The present study examined the production of P3HP from glycerol in the recombinant Klebsiella pneumoniae strain, which naturally synthesizes vitamin B12. The genes glycerol dehydratase and its reactivation factor (dhaB123, gdrA, and gdrB from K. pneumoniae), aldehyde dehydroge...

  8. Consumer protection in the food supplements area

    Luptáková, Marcela

    2014-01-01

    The topic of this diploma thesis is the Consumer protection in the food supplements area. The work has been devided into three parts. The first part is devoted to the overview about categorization of the products with the impact on health. This part of this work also includes the elementary terms, which are: food, food supplements, medicinal products, cosmetics products and medical devices. The second chapter is devoted to the matter of food supplements as such. The third chapter deals with t...

  9. MEMS Graphene Strain Sensor

    Young, Clinton Wen-Chieh

    Graphene is a two dimensional honeycomb structure of sp2 hybridized carbon atoms that has possibilities in many applications due to its excellent mechanical and electrical properties. One application for Graphene is in the field of sensors. Graphene's electronic properties do not degrade when it undergoes mechanical strain which is advantageous for strain sensors. In this thesis, certain properties, such as the piezo-resistivity and flexibility, of graphene will be explored to show how they can be utilized to make a strain sensing device. Our original fabrication process of patterning graphene and the transfer process of graphene onto a flexible substrate will be discussed. The development of a stretchable and flexible graphene based rosette strain sensor will also be detailed. Developing a novel, reliable patterning process for the graphene is the first step to manufacture a stretchable graphene based sensor. The graphene was patterned using a photolithography and etching process that was developed by our research team, then it was transferred to a flexible polymer substrate with the use of a combination of soft lithography and wet etching of the Ni foil with ferric chloride solution. Graphene patterning is an essential step in fabricating reliable and sensitive sensors. With this process, graphene can be consistently patterned into different shapes and sizes. To utilize the graphene as the sensing material it also needs to be transferred onto a flexible substrate. The innovative transfer process developed by our research team consistently adheres graphene to a flexible PDMS substrate while removing the original nickel substrate. In the end, the graphene was transferred from the metal substrate to the desired flexible substrate. This process was repeated multiple times to create a stack and multilayer device. While many graphene-based strain sensors have been developed, they are uni-directional and can only measure the strain applied on the sensor in a principle

  10. Dietary Supplement Ingredient Database (DSID): New Tool for Assessing Nutrient Intake from Dietary Supplements

    Accurate information on the nutrient composition of dietary supplements is essential for determining their contribution to dietary intake. This year, the preliminary release of dietary supplement composition information is now available for researchers' use in evaluating diet and health interrelatio...

  11. The proteolytic potential of Candida albicans in human saliva supplemented with glucose.

    Samaranayake, L P; Hughes, A; MacFarlane, T W

    1984-02-01

    The production of proteases by Candida albicans in batch cultures of human saliva supplemented with glucose was investigated with two clinical strains of Candida and both individual and pooled samples of whole saliva from volunteers. Salivary proteolysis during a 48-h period was estimated by biochemical and isoelectric focusing techniques. Candidal growth in saliva was associated with acid production and salivary proteolysis and there was a highly significant positive correlation between these two activities. Neither candidal growth nor proteolysis was observed in glucose-free control samples and with one strain of Candida cultured in the saliva of one individual. Isotachophoretic analysis of culture liquor showed a significant increase in acetate and pyruvate ions. The oral cavity provides niches that have a low pH and are periodically supplemented with dietary carbohydrates. The acidic proteases of C. albicans may play a role in the pathogenesis of oral candidoses. PMID:6363704

  12. Effect of hesperidin dietary supplementation on hen performance, egg quality and yolk oxidative stability.

    Goliomytis, M; Orfanou, H; Petrou, E; Charismiadou, M A; Simitzis, P E; Deligeorgis, S G

    2014-02-01

    1. The purpose of this study was to evaluate the effects of dietary supplementation with hesperidin (one or 3 g/kg of feed) for 31 d on the performance, egg quality and yolk oxidative stability of brown and white laying hens (26-wk old). 2. Supplementation with hesperidin did not affect egg production, egg weight and egg quality traits. 3. No hesperidin effect on yolk and plasma cholesterol was observed. A strain effect was found with lower total and per g yolk cholesterol of brown hens in comparison to the white ones. 4. Oxidative stability of egg yolk, expressed as ng MDA/g yolk, was significantly improved in the hesperidin groups even from the first week of supplementation. At the same time, a significant improvement in the oxidative stability of egg yolk due to the incorporation of hesperidin in hens' diet was observed after 30 and 90 d of storage at 20°C and 4°C, respectively. 5. No hesperidin by strain interaction was detected for any of the traits measured. 6. In conclusion, incorporation of hesperidin to laying hens' feed did not affect productive and egg qualitative traits. On the other hand, dietary hesperidin supplementation significantly improved oxidative stability of both fresh and stored eggs. Antioxidant properties of hesperidin seem to make it a promising natural agent for improving the shelf life of eggs. PMID:24397432

  13. [Antimicrobial susceptibility of Neisseria gonorrhoeae strains determined by disk diffusion].

    Llanes Caballero, R; Acosta Giraldo, J C; Sosa Puente, J; Guzmán Hernández, D; Gutiérrez González, O; Llop Hernández, A

    1999-01-01

    The Gonoccocus Laboratory of "Pedro Kourí" Tropical Medicine Institute carried out a study of in vitro susceptibility of Neisseria gonorrhoeae to penicillin, tetracycline, cefuroxime ceftriaxone, cefotaxine and ciprofoxacin by means of a disk diffusion method with the culture medium agar base GC plus supplement. In the first phase, the method was standardized and the reference N. gonorrhoeae ATCC 49226 strain was used whereas in the second phase, 50 gonococcal strains isolated in 8 provinces during 1995 and 1996 were examined. The results of such standardization confirmed that the antimicrobial susceptibility values were within the allowable limits. 52 and 34% of strains were resistant to penicillin and tetracycline respectively and all of them showed susceptibility to the rest of evaluated antimicrobial drugs. We recommend the use of the disk diffusion method for surveillance of gonococci resistance to these drugs in our country. PMID:10887570

  14. Evaluation the Sensory and Probiotics Properties of the Yogurt Supplemented with Carrot Juice

    Carmen R. Pop; Cătălina Topan; Ancuţa M. Rotar; Cristina Semeniuc; Liana Salanţă

    2015-01-01

    This study aimed to develop a new type of yogurt through addition of carrot juice. Yogurt is a fermented milk product obtained from fermentation of Lactobacillus bulgaricus and Streptococcus thermophilus strains. The effect of carrot juice at different levels (0%, 8%, 16%, 24%) on sensory properties and the viability of probiotic bacteria in yogurts during storage (21 days) at refrigerated temperature (4°C) was evaluated. The yogurt supplementation with 24 % carrot juice significantly improve...

  15. Fisioterapia pré-operatória na prevenção das complicações pulmonares em cirurgia cardíaca pediátrica Preoperative physiotherapy in prevention of pulmonary complications in pediatric cardiac surgery

    Josiane Marques Felcar; José Carlos dos Santos Guitti; Antônio César Marson; Jefferson Rosa Cardoso

    2008-01-01

    OBJETIVO: Avaliar a incidência e o risco de complicações pulmonares em crianças submetidas a intervenção fisioterapêutica pré e pós-operatória nas cirurgias cardíacas, bem como comparar com aquelas submetidas apenas a intervenção fisioterapêutica pós-operatória. MÉTODOS: Ensaio clínico aleatório, que incluiu 135 pacientes de zero a 6 anos com cardiopatias congênitas, submetidos à cirurgia cardíaca. Os pacientes foram aleatorizados para grupo intervenção (G1), que realizou fisioterapia pré e p...

  16. Fisioterapia respiratória e sua aplicabilidade no período pré-operatório de cirurgia cardíaca Respiratory physiotherapy and its application in preoperative period of cardiac surgery

    Regina Coeli Vasques de Miranda; Susimary Aparecida Trevizan Padulla; Carolina Rodrigues Bortolatto

    2011-01-01

    Procedimentos cirúrgicos torácicos podem alterar a mecânica respiratória, repercutindo na função pulmonar. A presença de profissionais fisioterapeutas é fundamental no preparo e na reabilitação dos indivíduos que são submetidos à cirurgia cardíaca, visto que dispõem de um grande arsenal de técnicas. O objetivo foi verificar a efetividade de exercícios respiratórios, com e sem a utilização de dispositivos, e o treinamento muscular respiratório pré-cirurgia cardíaca na redução das complicações ...

  17. Importância da fisioterapia no pré e pós-operatório de cirurgia cardíaca pediátrica Importance of pre- and postoperative physiotherapy in pediatric cardiac surgery

    Simone Cavenaghi; Silvia Cristina Garcia de Moura; Thalis Henrique da Silva; Talita Daniela Venturinelli; Lais Helena Carvalho Marino; Neuseli Marino Lamari

    2009-01-01

    Complicações no pós-operatório de cirurgia cardíaca pediátrica são freqüentes, destacando-se a atelectasia e a pneumonia. A fisioterapia contribui significativamente no tratamento destas complicações. Desta forma, este estudo buscou agrupar e atualizar os conhecimentos da atuação fisioterapêutica no pré-operatório e nas complicações pulmonares do pós-operatório de cirurgia cardíaca pediátrica. Observou-se a eficácia do tratamento fisioterapêutico por meio de diferentes técnicas específicas e ...

  18. Control de la glucemia en el postoperatorio de cirugía cardíaca: Informe del Consejo de Emergencias de la Sociedad Argentina de Cardiología

    Mariano N. Benzadón

    2012-02-01

    Full Text Available La hiperglucemia en el postoperatorio de cirugía cardÍaca es un hallazgo frecuente asociado a peor evolución, que afecta tanto a diabéticos como no diabéticos. A pesar de las múltiples publicaciones disponibles, aún no existe un abordaje universalmente aceptado a este problema. En una iniciativa originada en el Consejo de Emergencias de la Sociedad Argentina de Cardiología, se convocó a expertos de nuestro medio con el propósito de debatir cómo debe ser el manejo de la glucemia en el paciente crítico cardiovascular. Este documento refleja lo discutido en este evento académico con la intención de resumir los principales aspectos del control de la glucemia en el postoperatorio de cirugía cardíaca.

  19. Espectro óculo-aurículo-vertebral e malformações cardíacas Oculo-auriculo-vertebral spectrum and cardiac malformations

    Rafael Fabiano Machado Rosa

    2010-01-01

    Full Text Available OBJETIVO: Verificar a frequência e tipos de cardiopatias congênitas em uma amostra de pacientes portadores de espectro óculo-aurículo-vertebral (EOAV, tentando correlacionar a presença desta malformação com suas demais características clínicas e evolução. MÉTODOS: A amostra foi composta por 33 indivíduos, todos atendidos em um mesmo centro, no período de janeiro de 1975 a dezembro de 2007. Vinte e dois deles eram do sexo masculino e 11 do feminino e suas idades variaram de 1 dia a 17 anos. Todos apresentavam avaliação cariotípica normal por bandas GTG. Realizou-se uma coleta de dados referentes à sua história clínica, exame físico e resultado de avaliações complementares. RESULTADOS: Anormalidades cardíacas foram observadas em 13 pacientes (39,4%. Dessas, cinco (38,5% eram do tipo conotruncal, sendo o principal defeito a tetralogia de Fallot (n=2. Malformações não usuais identificadas incluíram o cor triatriatum e a dupla via de entrada de ventrículo esquerdo. Diferenças significativas entre as características clínicas do grupo com e sem cardiopatia foram verificadas somente em relação à idade na primeira avaliação, que foi mais baixa naqueles com malformações cardíacas. Cinco indivíduos foram a óbito, quatro deles portadores desses defeitos. CONCLUSÃO: Malformações cardíacas, em especial dos tipos conotruncal e septal, são frequentes entre pacientes com EOAV. A frequência encontrada em nosso estudo foi estatisticamente similar à da maior parte dos trabalhos descritos na literatura, que oscila de 18% a 58%. As cardiopatias congênitas também representam a principal causa de óbito desses indivíduos. Portanto, uma avaliação cardiológica, especialmente precoce, deveria ser sempre realizada nesses pacientes.OBJECTIVE: To verify the frequency and types of congenital heart defects in a sample of patients with oculo-auriculo-vertebral spectrum (OAVS, in an effort to correlate presence of these

  20. Doença celíaca: sua relação com a saúde bucal Celiac disease's relationship with the oral health

    Michelle Soares Rauen

    2005-04-01

    Full Text Available Doença Celíaca é uma intolerância permanente às proteínas contidas no glúten de alguns cereais, como o trigo, o centeio, a cevada e a aveia. A doença manifesta-se principalmente nos primeiros dois anos de vida, sendo o intestino delgado o principal órgão afetado, com manifestações clínicas de diarréia, vômitos e emagrecimento; porém, o diagnóstico, muitas vezes, é difícil, devido ao grande número de casos atípicos da doença. Nestes casos, os sintomas podem ser numerosos e diversificados, tais como baixa estatura, anemia, osteoporose, hipoplasia do esmalte dentário, além de sintomas próprios do quadro clínico de outras doenças imunológicas que podem associar-se à doença celíaca, tais como diabetes mellitus, dermatite herpertiforme, doenças da tireóide, alergia, estomatite aftosa recorrente, entre outras. Devido a essa associação, os profissionais da saúde procurados pelos pacientes podem não relacionar os sintomas à enteropatia; entretanto, esta, se não tratada, pode trazer várias outras complicações à saúde. O objetivo desta comunicação é demonstrar a importância das manifestações bucais, as quais, quando devidamente observadas, contribuem ao diagnóstico da doença celíaca.Celiac Disease is a permanent intolerance to proteins contained in the gluten of some cereals, such as wheat, rye, barley and oat. The disease appears mainly during the first two years of life, the small bowel being the main affected organ, with clinical manifestations such as diarrhea, vomiting and weight loss. The diagnosis, however, is often difficult, due to the large number of atypical manifestations of the disease. In such cases, numerous and diversified symptoms, such as low stature, anemia, osteoporosis, and dental enamel hypoplasia, may be concurrent with symptoms of immune diseases associated to the celiac disease (diabetes mellitus, dermatitis herpetiformis, thyroid diseases, allergy, and recurrent aphtous

  1. Glicemia perioperatória e complicações pós-operatórias em cirurgia cardíaca pediátrica

    Rodrigo Leal Alves

    2011-11-01

    Full Text Available FUNDAMENTO: Anestesia para cirurgia cardíaca pediátrica é sistematicamente realizada em pacientes graves sob condições fisiológicas anormais. No intraoperatório, existem variações significativas da volemia, temperatura corporal, composição plasmática e fluxo sanguíneo tecidual, além de ativação da inflamação, com consequências importantes. Medidas seriadas da glicemia podem indicar estados de exacerbação da resposta neuroendocrinometabólica ao trauma servindo como marcadores prognóstico de morbidade nessa população. OBJETIVO: Correlacionar os níveis de glicemia do período perioperatório de crianças submetidas a cirurgia cardíaca com a ocorrência de complicações no pós-operatório e comparar os níveis intraoperatórios de glicemia de acordo com as condições perioperatórias. MÉTODOS: Informações referentes ao procedimento anestésico-cirúrgico e condições perioperatórias dos pacientes foram coletadas em prontuário. Comparações das médias dos valores perioperatórios da glicemia nos grupos de pacientes que apresentaram, ou não, complicações pós-operatórias e as frequências referentes às condições perioperatórias foram estabelecidas conforme cálculo da razão de chances e em análises univariáveis não paramétricas. RESULTADOS: Valores mais elevados de glicemia intraoperatória foram observados nos indivíduos que apresentaram complicações pós-operatórias. Prematuridade, faixa etária, tipo de anestesia e caráter do procedimento não apresentaram influência na média glicêmica do intraoperatório. O emprego de Circulação Extracorpórea (CEC esteve associado a maiores valores de glicemia durante a cirurgia. Nos procedimentos com CEC, maiores níveis glicêmicos foram observados nos indivíduos que evoluíram com infecção e complicações cardiovasculares, nas cirurgias sem CEC essa mesma associação ocorreu com complicações infecciosas e hematológicas. CONCLUSÃO: N

  2. Sumário de atualização da II Diretriz Brasileira de Insuficiência Cardíaca Aguda 2009/2011

    Marcelo Westerlund Montera

    2012-05-01

    Full Text Available Nos últimos dois anos, observamos diversas modificações na abordagem diagnóstica e terapêutica dos pacientes com Insuficiência Cardíaca aguda (IC aguda, o que nos motivou quanto à necessidade da realização de um sumário de atualização da II Diretriz Brasileira de Insuficiência Cardíaca Aguda de 2009. Na avaliação diagnóstica, o fluxograma diagnóstico foi simplificado e foi fortalecido o papel da avaliação clínica e ecocardiograma. Na avaliação clínico-hemodinâmica admissional, o ecocardiograma hemodinâmico ganhou destaque no auxilio da definição dessa condição no paciente com IC aguda na sala de emergência. Na avaliação prognóstica, os biomarcadores tiveram seu papel mais bem estabelecido, e a síndrome cardiorrenal teve seus critérios e valor prognóstico mais bem definidos. Os fluxogramas de abordagem terapêutica foram revistos, tornando-se mais simples e objetivos. Dentre os avanços na terapêutica medicamentosa destacam-se a segurança e a importância da manutenção ou introdução dos betabloqueadores na terapêutica admissional. A anticoagulação, de acordo com as novas evidências, ganha um espectro maior de indicações. O edema agudo de pulmão tem bem estabelecido os seus modelos hemodinâmicos de apresentação com suas distintas formas de abordagens terapêuticas, com novos níveis de indicação e evidência. No tratamento cirúrgico da IC aguda, a revascularização miocárdica, a abordagem das lesões mecânicas e o transplante cardíaco foram revistos e atualizados. Este sumário de atualização fortalece a II Diretriz Brasileira de Insuficiência Cardíaca Aguda por mantê-la atualizada e rejuvenescida. Todos os clínicos cardiologistas que lidam com pacientes com IC aguda encontrarão na diretriz e em seu sumário de atualização importantes instrumentos no auxílio da prática clínica para o melhor diagnóstico e tratamento de seus pacientes.

  3. Papel del especialista en ejercicio físico en el programa de rehabilitación cardíaca Role played by the physical training specialist in the Program of Cardiac Rehabilitation.

    Reinol Hernández González

    2000-01-01

    Full Text Available Se mencionan algunos de los efectos positivos del ejercicio físico en pacientes cardiópatas, como son el aumento de la capacidad funcional en mujeres y en pacientes clasificados de alto riesgo, la mejoría de la frecuencia cardíaca y la presión arterial, etc. El artículo tuvo como objetivo explicar el funcionamiento de la sección de entrenamiento físico dentro de los programas de rehabilitación cardíaca. Se explicó el funcionamiento de la sección de ejercicio físico del Centro de Rehabilitación del Instituto de Cardiología de La Habana, así como el papel preponderante del especialista en ejercicio físico dentro de la rehabilitación cardíaca. Como conclusión, se determinó que en los programas de rehabilitación cardíaca, siempre existiera el Especialista en ejercicio físico, con los conocimientos necesarios que garanticen la salud y la seguridad del paciente. Some of the positive effects of physical exercise on patients suffering from heart disease, such as the increase of functional capacity in women and patients classified as high risk, the improvement of heart rate and arterial pressure, etc., are mentioned here. The objective of this paper was to explain the functioning of the section of physical training within the cardiac rehablitation programs. The functioning of this section at the Rehabilitation Center of the Cardiology Institute of Havana, as well as the leading role played by the physical training specialist in the cardiac rehabilitation were explained. To conclude, it was determined that in the cardiac rehabilitation programs there will always be a physical training specialist with the necessary knowledge to guarantee patient?s health and safety.

  4. Relação entre depressão, nível de BNP e comprometimento ventricular na insuficiência cardíaca

    Vera Barretto Aguiar

    2010-12-01

    Full Text Available FUNDAMENTO: A depressão é uma comorbidade frequente na insuficiência cardíaca (IC, mas os mecanismos relacionados a pior evolução de pacientes deprimidos com IC ainda não estão esclarecidos. OBJETIVO: Avaliar o papel da depressão grave na evolução dos pacientes com IC descompensada. MÉTODOS: Estudamos consecutivamente 43 pacientes com IC avançada e FE < 40,0%, hospitalizados para compensação cardíaca. Os pacientes, após história e exame físico, foram submetidos a exames laboratoriais, incluindo a dosagem de BNP. Após o diagnóstico de depressão, aplicou-se a escala de Hamilton-D. Depressão grave foi definida por escore igual ou maior que 18. As variáveis clínico-laboratoriais, segundo a presença ou não de depressão grave, foram analisadas pela regressão logística. A curva ROC definiu o ponto de corte para o BNP. RESULTADOS: Depressão grave ou muito grave foi identificada em 24 (55,8% pacientes. Os pacientes deprimidos graves não diferiram dos não deprimidos quanto à idade, sexo e função renal, mas apresentaram menor comprometimento cardíaco (FE 23,4 ± 7,2% vs 19,5 ± 5,2%; p = 0,046 e valores mais elevados do BNP (2.582,8 ± 1.596,6 pg/ml vs 1.206,6 ± 587,0 pg/ml; p < 0,001. Entretanto, os pacientes com BNP maior que 1.100 pg/ml tiveram 12,0 (odds ratio [IC 95%] = 2,61 - 55,26 vezes mais chance de desenvolverem quadros de depressão grave. CONCLUSÃO: Os pacientes com depressão grave apresentaram maior grau de estimulação neuro-hormonal, apesar do grau de disfunção ventricular ser menor. As alterações fisiopatológicas relacionadas à depressão, aumentando a estimulação neuro-hormonal e as citocinas, provavelmente contribuíram para essa maior manifestação clínica, mesmo em presença de menor dano cardíaco.

  5. Complicações microvasculares e disfunção autonômica cardíaca em pacientes com diabete melito tipo 1

    Fernando K Almeida

    2011-06-01

    Full Text Available FUNDAMENTO: A presença de neuropatia autonômica cardíaca (NAC em pacientes com diabete melito (DM está associada a aumento da mortalidade e a complicações crônicas microvasculares do diabete. OBJETIVO: Investigar uma possível associação entre achados sugestivos de NAC durante a realização do teste ergométrico (TE e nefropatia e retinopatia em pacientes com DM tipo 1. MÉTODOS: Realizamos um estudo transversal com 84 pacientes com DM tipo 1. Todos os pacientes foram submetidos à avaliação clínica e laboratorial e realizaram TE, sendo que aqueles que apresentaram achados sugestivos de isquemia miocárdica foram excluídos da análise dos dados (n = 3. A avaliação de complicações microvasculares (retinopatia e nefropatia foi realizada na amostra. RESULTADOS: Os pacientes com nefropatia e aqueles com retinopatia atingiram uma frequência cardíaca (FC durante o pico de exercício (FC máxima menor e apresentaram aumento menor da FC em relação ao repouso (ΔFC pico quando comparados com aqueles sem estas complicações. Esses pacientes também apresentaram menor redução da FC no segundo e 4º minutos após o final do teste (ΔFC recuperação dois e 4 minutos. Após realização de análise multivariada com controle para os possíveis fatores de confusão, os ΔFC recuperação em dois e 4 minutos, FC máxima e o ΔFC pico permaneceram significativamente associados à retinopatia; e os ΔFC recuperação no segundo e 4º minutos permaneceram associados à presença de nefropatia. CONCLUSÃO: O TE pode ser considerado um instrumento adicional para a detecção precoce de NAC e para identificar pacientes em maior risco para complicações microvasculares do diabete.

  6. É necessário suspender o betabloqueador na insuficiência cardíaca descompensada com baixo débito?

    Marcelo Villaça Lima

    2010-10-01

    Full Text Available FUNDAMENTO: Há evidências de que a suspensão do betabloqueador (BB na descompensação cardíaca pode aumentar mortalidade. A dobutamina (dobuta é o inotrópico mais utilizado na descompensação, no entanto, BB e dobuta atuam no mesmo receptor com ações antagônicas, e o uso concomitante dos dois fármacos poderia dificultar a compensação. OBJETIVO: Avaliar se a manutenção do BB associado à dobuta dificulta a compensação cardíaca. MÉTODOS: Estudados 44 pacientes com FEVE < 45% e necessidade de inotrópico. Divididos em três grupos de acordo com o uso de BB. Grupo A (n=8: os que não usavam BB na admissão; Grupo B (n=25: os que usavam BB, porém foi suspenso para iniciar a dobuta; Grupo C (n=11: os que usaram BB concomitante à dobuta. Para comparação dos grupos, foram utilizados os testes t de Student, exato de Fisher e qui-quadrado. Considerado significante p < 0,05. RESULTADOS: FEVE média de 23,8 ± 6,6%. O tempo médio do uso de dobuta foi semelhante nos três grupos (p=0,35, e o uso concomitante da dobuta com o BB não aumentou o tempo de internação (com BB 20,36 ± 11,04 dias vs sem BB 28,37 ± 12,76 dias, p=NS. Na alta, a dose do BB foi superior nos pacientes em que a medicação não foi suspensa (35,8 ± 16,8 mg/dia vs 23,0 ± 16,7 mg/dia, p=0,004. CONCLUSÃO: A manutenção do BB associado à dobuta não aumentou o tempo de internação e não foi acompanhada de pior evolução. Os pacientes que não suspenderam o BB tiveram alta com doses mais elevadas do medicamento.

  7. Análisis de costos hospitalarios de la insuficiencia cardíaca con función sistólica conservada versus deteriorada

    Mariano A. Giorgi,

    2008-01-01

    Full Text Available IntroducciónLa insuficiencia cardíaca (IC es un problema de salud de creciente importancia, especialmente entre los pacientes añosos. Sobre la base de la función sistólica del ventrículo izquierdo (FSVI, existen dos tipos de insuficiencia cardíaca (IC con FSVI deteriorada e IC con FSVI conservada que se caracterizan por tener diferencias fisiopatológicas y clínicas. Nuestra hipótesis es que esto podría devenir en una diferente utilización de los recursos de la salud.Pese a su importancia, no existen en la Argentina registros que comparen los costos hospitalarios de estas dos formas de IC en pacientes añosos, población en la que predomina la IC con FSVI conservada (fracción de eyección ≥ 50%.ObjetivoAnalizar los costos hospitalarios de estas dos formas de IC en pacientes añosos.Material y métodosSe analizaron datos de 133 pacientes añosos internados por IC. La muestra se dividió según la FSVI; se compararon las características previas y durante la hospitalización y los costos totales desde la perspectiva del financiador.ResultadosLa IC con FSVI conservada fue más frecuente (55,6% y con predominio femenino. No se observaron grandes diferencias entre ambos grupos, excepto para el uso de espironolactona y la cantidad de medicaciones recibidas, que fue más frecuente en el grupo con FSVI deteriorada.Esta última presentó un costo total mayor (27% más respecto de la otra variante, mayor tiempo de internación y un costo de medicamentos más elevado.ConclusionesSi bien el número de pacientes es reducido, el presente trabajo brinda una aproximación acerca de la importancia del análisis de costos de ambas formas de IC en sujetos añosos en la Argentina, lo cual constituye el paso inicial para la proyección de los gastos en salud.

  8. Hematoma disecante intramiocárdico: una forma poco frecuente de rotura cardíaca Intramyocardial dissecting haematoma: an unusual form of cardiac rupture

    F.J. García Fernández

    2003-08-01

    Full Text Available El hematoma disecante intramiocárdico es una complicación mecánica del infarto agudo de miocardio que consiste en la formación de una neocavitación causada por la disección hemorrágica entre las fibras espirales miocárdicas y que se encuentra contenida dentro del miocardio. Es una rotura de pared libre que aparece en el 9% de las autopsias de roturas cardíacas postinfarto. Su diagnóstico es complejo y aparece en la mayor parte de los pacientes "postmortem". Comentamos el caso de un paciente de 69 años que sufrió un infarto posterolateral y fue tratado con angioplastia primaria/ stent en las primeras horas así como con ácido acetil salicílico, clopidogrel, heparina sódica y antagonistas de GPIIb-IIIa. En las siguientes horas presentó esta rara forma de rotura cardíaca que le llevó al shock cardiogénico y le causó la muerte. Se revisa la fisiopatología, diagnóstico y manejo de esta entidad que presenta una alta letalidad (90% en los pacientes tratados médicamente y cuyo único tratamiento es la cirugía.The intramyocardial dissecting haematoma is an unusual rupture of the left ventricular wall, complicating acute myocardial infarction. The mechanism is an hemorrhagic dissection among the spiral myocardial fibres creating a neocavitation limited by the myocardium. It appears in 9% of left ventricular wall ruptures, complicating acute myocardial infarction. Diagnosis is often difficult and in most of the cases it is post-mortem. We present the case report of a 69 year old patient who suffered a posterolateral acute myocardial infarction treated with primary PTCA/Stent plus AAS, clopidogrel, unfractioned heparin bolus and GP IIb- IIIa inhibitors. In the following few hours he suffered this unusual form of cardiac rupture that took him into cardiogenic shock and finally led to his death. The pathophysiology, diagnosis and management of this lethal complication of acute myocardial infarction (90% mortality in the medically

  9. Three Strains of Pseudomonas fluorescens Exhibit Differential Toxicity Against Drosophila melanogaster

    Three strains of Pseudomonas fluorescens were tested for toxicity to Drosophila melanogaster in an insect feeding assay. Insect eggs were placed on the surface of a non-nutritive agar plate supplemented with a food source that was non-inoculated or inoculated with P. fluorescens Pf0-1, SBW25, or Pf-...

  10. Improved functionality of fermented milk is mediated by the synbiotic interaction between Cudrania tricuspidata leaf extract and Lactobacillus gasseri strains.

    Oh, Nam Su; Lee, Ji Young; Oh, Sangnam; Joung, Jae Yeon; Kim, Su Gyeong; Shin, Yong Kook; Lee, Kwang-Won; Kim, Sae Hun; Kim, Younghoon

    2016-07-01

    This study was designed to investigate the cooperative effect of selected Lactobacillus gasseri strains and Cudrania tricuspidata (CT) leaf extract in enhancing the health-promoting activities of fermented milk. Addition of CT increased total bacterial counts and proteolysis during fermentation of milk with L. gasseri strains. Antioxidant capacities were determined by measuring the ABTS, DPPH, and peroxyl radical scavenging activities and ferric reducing power. The antioxidant capacity of CT-supplemented milk was greater than that of milk without supplementation; moreover, the antioxidant activity of CT-supplemented milk was synergistically improved by fermentation with L. gasseri strains. In particular, CT-supplemented milk fermented by L. gasseri 505 showed the highest antioxidant activity. The phenolic compounds in CT, such as neo-chlorogenic, chlorogenic, and caffeic acid, were metabolized during fermentation with L. gasseri strains, and 3,4-dihydroxy-hydrocinnamic acid was produced as a fermentation metabolite. Moreover, the liberation of bioactive peptides of fermented milk was increased by the proteolytic activity of L. gasseri strains. In particular, six peptides, which were mainly derived from β-casein, were newly identified in this study. These findings suggest that L. gasseri strains metabolize the phenolic acids in the CT and the bioactive peptides released through this interaction improve the antioxidant activity of the fermented milk. PMID:26996626

  11. Dietary Supplements and Sports Performance: Herbals

    Williams Melvin

    2006-06-01

    Full Text Available Abstract This is the fourth in a series of six articles to discuss the major classes of dietary supplements (vitamins; minerals; amino acids; herbs or botanicals; metabolites, constituents/extracts, or combinations. The major focus is on efficacy of such dietary supplements to enhance exercise or sport performance.

  12. Antioxidant supplements for preventing gastrointestinal cancers

    Bjelakovic, G; Nikolova, D; Simonetti, R G;

    2004-01-01

    Oxidative stress may cause gastrointestinal cancers. The evidence on whether antioxidant supplements are effective in preventing gastrointestinal cancers is contradictory.......Oxidative stress may cause gastrointestinal cancers. The evidence on whether antioxidant supplements are effective in preventing gastrointestinal cancers is contradictory....

  13. Dietary Supplements and Sports Performance: Herbals

    Williams Melvin

    2006-01-01

    Abstract This is the fourth in a series of six articles to discuss the major classes of dietary supplements (vitamins; minerals; amino acids; herbs or botanicals; metabolites, constituents/extracts, or combinations). The major focus is on efficacy of such dietary supplements to enhance exercise or sport performance.

  14. Antioxidant supplements for preventing gastrointestinal cancers

    Bjelakovic, Goran; Nikolova, Dimitrinka; Simonetti, Rosa G;

    2008-01-01

    Oxidative stress may cause gastrointestinal cancers. The evidence on whether antioxidant supplements are effective in preventing gastrointestinal cancers is contradictory.......Oxidative stress may cause gastrointestinal cancers. The evidence on whether antioxidant supplements are effective in preventing gastrointestinal cancers is contradictory....

  15. Dietary Supplements and Sports Performance: Amino Acids

    Williams Melvin

    2005-01-01

    Abstract This is the third in a series of six articles to discuss the major classes of dietary supplements (vitamins; minerals; amino acids; herbs or botanicals; metabolites, constituents/extracts, or combinations). The major focus is on efficacy of such dietary supplements to enhance exercise or sport performance.

  16. Enhanced Nutrition Education Instead of Consuming Supplements

    Crowder, Todd; Kidd, Kellie; Jensen, Nancy; Jensen, Laura

    2008-01-01

    Fueled by the internet, instantaneous videos, and the emphasis to look "right" or always win athletic competitions, many students are seeking information on nutrition and dietary supplements. Classroom observations reveal student interest and discussions are among the highest when the topic is dietary supplements. Teachers and coaches provide an…

  17. 14 CFR 91.211 - Supplemental oxygen.

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Supplemental oxygen. 91.211 Section 91.211 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC...) At flight altitudes above flight level 250 unless at least a 10-minute supply of supplemental...

  18. CURRENT POPULATION SURVEY MARRIAGE AND FERTILITY SUPPLEMENT

    These supplements to the June round of the Current Population Survey (conducted at five-year intervals starting in 1971) were designed to examine transitions in the American family and to measure the demographic implications of these transitions for children. The supplements ask ...

  19. 30 CFR 75.361 - Supplemental examination.

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Supplemental examination. 75.361 Section 75.361... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Ventilation § 75.361 Supplemental examination. (a) Except for certified persons conducting examinations required by this subpart, within 3 hours before...

  20. Assessing the economic impacts of commercial poultry feeds supplementation and vaccinating against Newcastle disease in local chickens, in Kenya

    Despite of the rapid growth in poultry population in the past decade, various constraints continue to adversely affect the productivity of local birds in Kenya. Sustainable cost effective interventions are necessary if full potential is to be realised. The impact of Newcastle disease (ND) control using vaccination and commercial poultry feed supplementation was assessed in 16 farms found in Kiambu district (ECZ II). Information on flock size, flock structure and disease control was gathered from these farms. F strain ND vaccine administration and commercial poultry feed supplementation was also done. Generally there was a notable increase in flock size when birds were supplemented and vaccinated. There was marked increase in numbers of growers and chicks with feed supplementation and vaccination. It was economically profitable to supplement and vaccinate local birds as returns were >1.0. Vaccination gave the highest return on investment (3,36) and feed supplementation the least (1,15). The high cost of commercial poultry feed discourages farmers from supplementing local chicken; therefore farm formulations using locally available materials should be encouraged. There is need to produce thermostable vaccines locally to use in local birds which would bring vaccine costs further down. (author)

  1. Longitudinal misalignment based strain sensor

    Andrews, Jeffrey Pratt

    1989-01-01

    A practical fiber optic strain sensor has been developed to measure strains in the range of 0.0 to 2.0 percent strain with a resolution ranging between 10 and 100 microstrain depending on sensor design choices. This intensity based sensor measures strain by monitoring strain induced longitudinal misalignment in a novel fiber interconnection. This interconnection is created by aligning fibers within a segment of hollow core fiber. Related splice loss mechanisms are investigated ...

  2. Adaptive parameters and thermal comfort of postpartum ewes fed on concentrate supplementation in grazing system

    Ronne-von Ribeiro da Rocha

    2014-07-01

    Full Text Available Current analysis evaluated adaptive parameters and thermal comfort of postpartum ewes fed on concentrate supplementation in grazing system. Thirty lactating pluriparous sheep, 16 Santa Inês (SI and 14 Morada Nova (MN were used. Physiological parameters such as respiratory rate (RR, heart rate (HR and rectal temperature (RT were measured, in that order, with the animals at rest in the morning (6:00-7:00 am and in the afternoon (1:00-2:00 pm, respectively, every seven days, with 10 samples. A significant effect (p < 0.05 for RR and HR was reported in the strain. Similar behavior was reported for RR between the breeds where MN sheep had high adaptability. Supplementation levels of 0.5 and 1.5% influenced (p < 0.05 RR which was stronger in the sheep that received the highest supplementation level, possibly due to calorie increase in the diet. However, HR and RT parameters did not differ within the breed due to supplementation. HR was higher between the breeds for SI sheep at 0.5%. Results show that concentrated supplementation affected the respiratory rate of ewes in the postpartum period, with higher calorie increment at 1.5% level and superiority for Santa Inês ewes. Greater adaptability of Morada Nova sheep has been indicated when fed on concentrated diet in grazing system.

  3. Regional Assessment of Supplementation Project. Status report

    1991-10-01

    The Fish and Wildlife Program of the Northwest Power Planning Council (NPPC) prescribes several approaches to achieve its goal of doubling the salmon and steelhead runs of the Columbia River. Among those approaches are habitat restoration, improvements in adult and juvenile passage at dams and artificial propagation. Supplementation will be a major part of the new hatchery programs. The purpose of the Regional Assessment of Supplementation Project (RASP) is to provide an overview of ongoing and planned supplementation activities, to construct a conceptual framework and model for evaluating the potential benefits and risks of supplementation and to develop a plan for better regional coordination of research and monitoring and evaluation of supplementation. RASP has completed its first year of work. Progress toward meeting the first year`s objectives and recommendations for future tasks are contained in this report.

  4. Regional Assessment of Supplementation Project : Status Report.

    Unknown author

    1991-10-01

    The Fish and Wildlife Program of the Northwest Power Planning Council (NPPC) prescribes several approaches to achieve its goal of doubling the salmon and steelhead runs of the Columbia River. Among those approaches are habitat restoration, improvements in adult and juvenile passage at dams and artificial propagation. Supplementation will be a major part of the new hatchery programs. The purpose of the Regional Assessment of Supplementation Project (RASP) is to provide an overview of ongoing and planned supplementation activities, to construct a conceptual framework and model for evaluating the potential benefits and risks of supplementation and to develop a plan for better regional coordination of research and monitoring and evaluation of supplementation. RASP has completed its first year of work. Progress toward meeting the first year's objectives and recommendations for future tasks are contained in this report.

  5. Mineral supplementation in Tunisian smallholder dairy farms

    The aim of the experiment was to determine the effects of supplementation of di-calcium-phosphate in the form of blocks in late pregnancy (2 months before calving), on production and reproduction parameters of dairy cattle in smallholder farms. The experiment covered 63 animals in 20 smallholder farms, divided into control and supplemented groups. Results showed that mineral supplementation had a significant effect on calf weight, milk fat content and reproduction parameters. Calves born to cattle supplemented with di-calcium-phosphate were heavier by 1.67 kg than those in the control group. Similarly, the average milk fat content in the supplemented group was 5.6 g/L (P0.05). (author)

  6. ConStrains identifies microbial strains in metagenomic datasets.

    Luo, Chengwei; Knight, Rob; Siljander, Heli; Knip, Mikael; Xavier, Ramnik J; Gevers, Dirk

    2015-10-01

    An important fraction of microbial diversity is harbored in strain individuality, so identification of conspecific bacterial strains is imperative for improved understanding of microbial community functions. Limitations in bioinformatics and sequencing technologies have to date precluded strain identification owing to difficulties in phasing short reads to faithfully recover the original strain-level genotypes, which have highly similar sequences. We present ConStrains, an open-source algorithm that identifies conspecific strains from metagenomic sequence data and reconstructs the phylogeny of these strains in microbial communities. The algorithm uses single-nucleotide polymorphism (SNP) patterns in a set of universal genes to infer within-species structures that represent strains. Applying ConStrains to simulated and host-derived datasets provides insights into microbial community dynamics. PMID:26344404

  7. Insuficiência cardíaca com fração de ejeção normal Insuficiencia cardíaca con fracción de eyección normal Heart failure with normal ejection fraction

    Meliza Goi Roscani; Luiz Shiguero Matsubara; Beatriz Bojikian Matsubara

    2010-01-01

    A insuficiência cardíaca com fração de ejeção normal (ICFEN) é uma síndrome complexa que vem sendo largamente estudada, desde a última década. É causada por disfunção ventricular diastólica evidenciada por métodos complementares, como estudo hemodinâmico ou ecocardiograma, na presença de fração de ejeção preservada. Acomete preferencialmente indivíduos mais idosos e com comorbidades, como hipertensão arterial sistêmica, insuficiência coronariana e obesidade. Os mecanismos fisiopatológicos são...

  8. Selection of Saccharomyces cerevisiae strains for efficient very high gravity bio-ethanol fermentation processes

    Pereira, Francisco B; Guimarães, Pedro M. R.; J. A. Teixeira; Domingues, Lucília

    2010-01-01

    Abstract An optimized very high gravity (VHG) glucose medium supplemented with low cost nutrient sources was used to evaluate bio-ethanol production by 11 Saccharomyces cerevisiae strains. The industrial strains PE-2 and CA1185 exhibited the best overall fermentation performance, producing an ethanol titre of 19.2% (v/v) corresponding to a batch productivity of 2.5 g l?1 h?1, while the best laboratory strain (CEN.PK 113-7D) produced 17.5% (v/v) ethanol with a productivity of 1.7 g ...

  9. HERBAL SUPPLEMENTS: CAUSE FOR CONCERN?

    Paolo Borrione

    2008-12-01

    Full Text Available More than 1400 herbal products or herbal-derived compounds are commonly commercialised for health uses worldwide (Tyler, 1996. Herbs are considered dietary supplements, and therefore are subjected to a very limited form of regulation, and advertisements normally highlight their potential activities without mentioning any side effect. Also, herbs are generally believed to be 'natural', and hence safe. Many nutritional supplements contains herb compounds usually not present in the diet (e.g. Ginko biloba, horse- chestnut, and only 10% of the herbs used in nutritional supplements are commonly present in the food (e.g. garlic, soy, blueberry, green the, ginger, curcuma (Eisenberg et al., 1993. There is much interest in "alternative natural approaches" in sport. It is appealing for athletes to use 'natural' substances with similar activity to 'pharmacological' ones in term of improving performance, are not considered doping, and are considered side-effects free (Table 1. Indeed, many herbal dietary supplements marketed on internet are presented as legal alternative to illicit drugs (Denneey et al., 2005. EcdysteroidsEcdysteroids are the steroid hormones of arthropods (Figure 1. They also occur in some plants, where they are known as phytoecdysteroids, and are believed to contribute to deter invertebrate predators. In insects, they regulate moulting and metamorphosis, may regulate reproduction and diapause. Most actions of ecdysteroids are mediated by intracellular receptor complexes, which regulate gene expression in a tissue- and development-specific manner (Lehmann et al 1989.Several phytoecdysteroids have anabolic growth-promoting effects on mice, rats, pigs and Japanese quails. Ecdysteroids stimulate muscle growth, and this anabolic effect promotes increased physical performance without training. Ecdysteroids are also able to increase muscle ATP content in vitamin D-deprived rats (Báthori, 2002. Ecdysteroids stimulate protein synthesis in the

  10. The strained state cosmology

    Tartaglia, Angelo

    2016-01-01

    Starting from some relevant facts concerning the behavior of the universe over large scale and time span, the analogy between the geometric approach of General Relativity and the classical description of an elastic strained material continuum is discussed. Extending the elastic deformation approach to four dimensions it is shown that the accelerated expansion of the universe is recovered. The strain field of space-time reproduces properties similar to the ones ascribed to the dark energy currently called in to explain the accelerated expansion. The strain field in the primordial universe behaves as radiation, but asymptotically it reproduces the cosmological constant. Subjecting the theory to a number of cosmological tests confirms the soundness of the approach and gives an optimal value for the one parameter of the model, i.e. the bulk modulus of the space-time continuum. Finally various aspects of the Strained State Cosmology (SSC) are discussed and contrasted with some non-linear massive gravity theories. The possible role of structure topological defects is also mentioned. The conclusion is that SSC is at least as good as the ΛCDM standard cosmology, giving a more intuitive interpretation of the physical nature of the phenomena.

  11. Peculiaridades no pós-operatório de cirurgia cardíaca no paciente idoso Peculiaridades en el post operatorio de cirugía cardíaca en el paciente de edad avanzada Peculiarities of post-cardiac surgery care in elderly patients

    Paulo de Oliveira Vasconcelos Filho

    2004-10-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O paciente idoso tem características fisiológicas próprias e, muitas vezes, pode apresentar deficiências orgânicas ou afecções graves, que por si, já tornam o pós-operatório complicado. O objetivo deste artigo é apresentar uma revisão das condutas pós-operatórias de cirurgia cardíaca no idoso, apresentando as alterações mais freqüentes nesse tipo de paciente. CONTEÚDO: As condutas no período intra-operatório do paciente idoso devem ser tomadas tendo em vista a diminuição da morbidade pós-operatória. Na chegada do paciente idoso à UTI, devem ser cumpridos os mesmos critérios utilizados na internação de outros pacientes adultos de cirurgia cardíaca, para o serviço ter sempre um padrão, que não leve a uma alteração na rotina e que não provoque equívocos. Estabelecer um plano de cuidados intensivos para o pós-operatório de cirurgia cardíaca irá resultar em uma ótima utilização de recursos da unidade, em efetividade de atenção e em diminuição do tempo nos cuidados em relação ao paciente idoso. Os exames auxiliares solicitados também devem seguir um padrão, estabelecido pelo serviço, a não ser que alterações sejam identificadas. Complicações neurológicas, pulmonares, circulatórias, insuficiência renal, infecção e hipotireoidismo são freqüentes, com particularidades no idoso. Elas estão delineadas neste artigo e devem ser bem compreendidas pelo intensivista que cuida desse tipo de paciente. CONCLUSÕES: As complicações apresentadas neste artigo são as que trazem maior preocupação ao intensivista, quando há um paciente idoso em pós-operatório de cirurgia cardíaca na UTI. Este paciente necessita de cuidados especiais, mesmo quando a cirurgia transcorre em perfeita normalidade, pois o estresse cirúrgico é muito grande e o idoso tem reserva funcional diminuída.JUSTIFICATIVA Y OBJETIVOS: El paciente de edad avanzada tiene características fisiol

  12. Avaliação da intensidade de dor e sinais vitais no pós-operatório de cirurgia cardíaca

    Adriana de Fátima Alencar Miranda

    2011-04-01

    Full Text Available O objetivo do estudo é analisar as alterações nos sinais vitais de pacientes em pós-operatório de cirurgias cardíacas, mediante intensidade de dor referida. Trata-se de estudo descritivo-exploratório, que utilizou o método de análise quantitativa na investigação de 38 pacientes submetidos à primeira renovação de curativos. A análise dos dados, mensurados antes e após a realização do procedimento de enfermagem, indicaram que a manifestação da dor ocorreu em diferentes classificações. As principais alterações nos sinais vitais ocorreram na pressão arterial. Concluiu-se que a intensidade dolorosa mantém relações com os resultados dos sinais vitais e o cuidado prestado é imprescindível ao restabelecimento do estado de saúde do paciente no pós-operatório.

  13. Unusual suppression of low energy spin excitations near Fermi level in AFe4Sb12 (A=Ca, Sr, and Ba) probed by Sb-NQR

    Sb nuclear quadrupole resonances (NQR) have been performed on the alkaline-earth filled skutterudite AFe4Sb12 (A=Ca, Sr, and Ba) being close to ferromagnetic instability. No hyperfine splitting in NQR spectrum even at the lowest temperature (1.5 K) confirms an absence of uniform ferromagnetic order in these compounds. Above about T* - 70 K, the nuclear spin-lattice relaxation rate divided by temperature, 1/T1T, follows an empirical relationship 1/T1T=a+b χspin with respect to the Curie Weiss (CW) like T-dependence of the static spin susceptibility χspin. The correlation between 1/T1T and χspin is consistent with the self-consistent renormalization (SCR) theory for the three-dimensional (3D) nearly ferromagnet despite the relatively large contribution of the first term not correlating to χspin. However, below about T*, 1/T1T exhibits a gap-like suppression with a gap magnitude of about 65 K. This unusual suppression of the low energy spin excitations is contrasting to the case in LaFe4Sb12, and a characteristic feature in the filled skutterudites with divalent filler ion. The pseudo-gap structure near the Fermi level is proposed for the hybridized Fe3d-Sb5p band (mainly partial p state) for the unusual suppression. (author)

  14. Alterações da hemostasia em crianças submetidas a cirurgia cardíaca com circulação extracorpórea

    Silveira Fernanda Maria Rebouças da Costa

    1998-01-01

    Full Text Available OBJETIVO: Avaliar as alterações de hemostasia encontradas em crianças submetidas a cirurgia cardíaca com circulação extracorpórea (CEC. MÉTODOS: Estudamos 17 crianças no pré e pós-operatório (PO imediato, no 1° PO e entre o 4º e 7º PO, analisando o hematócrito, tempo de protrombina (TP, tempo de tromboplastina parcial ativado, fibrinogênio, contagem de plaquetas, fator V e tempo de lise de euglobulina (TLE. Os pacientes foram divididos em grupos com e sem sangramento excessivo no PO. RESULTADOS: Houve alterações significantes no intra-operatório com aumento do TP e tempo de tromboplastina parcial ativado e redução do fibrinogênio, fator V e do TLE. Seis (35% crianças sangraram excessivamente. A contagem de plaquetas foi significantemente menor no intra-operatório; neste grupo o tempo de CEC foi maior. CONCLUSÃO: Alterações de hemostasia no intra e PO ocorrem como conseqüência da ativação da cascata de coagulação e fibrinólise. A incidência de sangramento excessivo é alta nesta faixa etária. Os grupos com e sem sangramento excessivo diferenciaram-se pelo maior tempo de CEC e contagem reduzida de plaquetas.

  15. Uso de levosimendana em diversos quadros de insuficiência cardíaca aguda Levosimendan use in several scenarios of acute heart failure

    Miguel Tavares

    2008-03-01

    Full Text Available Nos países em que é comercializada, a administração precoce de levosimendana deve ser considerada em pacientes que permanecem sintomáticos e com dispnéia em repouso apesar da terapia inicial, principalmente aqueles com história de insuficiência cardíaca crônica ou em tratamento prolongado com betabloqueadores. Pacientes hipotensos ou com isquemia ativa não são os melhores candidatos para receber infusão de levosimendana e precisam, primeiro, ter esses problemas tratados.In countries where it is available, early levosimendan infusion can be considered for patients who remain symptomatic with dyspnea at rest despite initial therapy, particularly those with a history of chronic heart failure or chronically treated with beta-blockers. Hypotensive patients or patients with active ischemia are not the best candidates for levosimendan administration and should have these problems addressed first.

  16. Aspectos relevantes da doença arterial coronariana em candidatos à cirurgia não cardíaca

    Gilson Cassem Ramos

    2010-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Devido à sua prevalência, a doença arterial coronariana (DAC constitui a principal causa de morbimortalidade em cirurgias eletivas, o que justifica a presente revisão, cujo objetivo foi principalmente estabelecer condutas pré-operatórias baseadas em normas e diretrizes para minimizar a morbimortalidade peri e pós-operatória dos portadores de DAC. CONTEÚDO: São apresentadas características gerais da DAC, assim como seus mecanismos fisiopatogênicos, as principais variáveis relacionadas ao preparo pré-operatório de pacientes com DAC, bem como condutas frente aos enfermos de maior risco cirúrgico. CONCLUSÕES: Portadores de DAC candidatos à cirurgia não cardíaca devem ser rigorosamente avaliados. Os identificados como de alto risco podem beneficiar-se com testes pré-operatórios provocativos de isquemia miocárdica, assim como de intervenções coronarianas invasivas, precedendo operações cirúrgicas eletivas. Em pacientes selecionados, deve-se considerar o uso de betabloqueador e de estatinas .

  17. Stability and oxygen ionic conductivity of zircon-type Ce 1- xAxVO 4+ δ ( A=Ca, Sr)

    Tsipis, E. V.; Kharton, V. V.; Vyshatko, N. P.; Shaula, A. L.; Frade, J. R.

    2003-11-01

    Zircon-type Ce 1- xAxVO 4+ δ ( A=Ca, Sr; x=0-0.2) are stable in air up to approximately 1300 K, whilst further heating or reducing oxygen partial pressure leads to formation of A-site deficient zircon and CeO 2- δ phases. The stability boundaries of Ce 1- xAxVO 4+ δ are comparable to those of vanadium dioxide and calcium orthovanadate. At oxygen pressures lower than 10 -15 atm, perovskite-type CeVO 3- δ is formed. The oxygen ion transference numbers of Ce 1- xAxVO 4+ δ, determined by faradaic efficiency measurements in air, vary in the range from 2×10 -4 to 6×10 -3 at 973-1223 K, increasing with temperature. The oxygen ionic conductivity has activation energy of 87-112 kJ/mol and is essentially independent of A-site dopant content. Contrary to the ionic transport, p-type electronic conductivity and Seebeck coefficient of Ce 1- xAxVO 4+ δ are influenced by the divalent cation concentration. The average thermal expansion coefficients of Ce 1- xAxVO 4+ δ, calculated from high-temperature XRD and dilatometric data in air, are (4.7-6.1)×10 -6 K -1.

  18. Stability and oxygen ionic conductivity of zircon-type Ce1-xAxVO4+δ (A=Ca, Sr)

    Zircon-type Ce1-xAxVO4+δ (A=Ca, Sr; x=0-0.2) are stable in air up to approximately 1300 K, whilst further heating or reducing oxygen partial pressure leads to formation of A-site deficient zircon and CeO2-δ phases. The stability boundaries of Ce1-xAxVO4+δ are comparable to those of vanadium dioxide and calcium orthovanadate. At oxygen pressures lower than 10-15 atm, perovskite-type CeVO3-δ is formed. The oxygen ion transference numbers of Ce1-xAxVO4+δ, determined by faradaic efficiency measurements in air, vary in the range from 2x10-4 to 6x10-3 at 973-1223 K, increasing with temperature. The oxygen ionic conductivity has activation energy of 87-112 kJ/mol and is essentially independent of A-site dopant content. Contrary to the ionic transport, p-type electronic conductivity and Seebeck coefficient of Ce1-xAxVO4+δ are influenced by the divalent cation concentration. The average thermal expansion coefficients of Ce1-xAxVO4+δ, calculated from high-temperature XRD and dilatometric data in air, are (4.7-6.1)x10-6 K-1

  19. Acurácia na inferência de diagnósticos de enfermagem de pacientes com insuficiência cardíaca

    Juliana de Melo Vellozo Pereira

    2015-08-01

    Full Text Available RESUMOInsuficiência cardíaca (IC é causa frequente de internação exigindo do enfermeiro precisão na conduta clínica e adequado julgamento dos diagnósticos de enfermagem.Objetivo:verificar acurácia na determinação dos diagnósticos de enfermagem fadiga, intolerância à atividade e débito cardíaco diminuído em paciente com IC hospitalizados.Método:estudo descritivo aplicado aos enfermeiros experientes em diagnósticos de enfermagem NANDA-I e/ou IC. Avaliação da acurácia foi realizada a partir do cálculo das medidas: eficácia (E, falso negativo (FN, falso positivo (FP e tendência (T. Foram aptos os enfermeiros com inspeção aceitável para dois diagnósticos.Resultados:o diagnóstico de enfermagem fadiga foi o mais erroneamente identificado pelos enfermeiros avaliadores.Discussão:a busca pelo aperfeiçoamento da acurácia diagnóstica reafirma a necessidade de treinamento contínuo e específico para a melhora da capacidade diagnosticadora do enfermeiro.Conclusão:o treinamento permitiu o exercício do raciocínio clínico e melhor acurácia dos enfermeiros.

  20. Coronariografía por tomografía de 64 cortes. Precisión diagnóstica según puntaje de calcio y frecuencia cardíaca

    Vladimir Mendoza-Rodríguez

    2007-01-01

    Full Text Available Introducción y ObjetivosLa coronariografía invasiva (CI es el patrón estándar para el estudio de las coronarias con un bajo índice de complicaciones. La tomografía computarizada multicorte (TCMC permite el estudio mínimamente invasivo del árbol coronario. El objetivo del presente trabajo estuvo dirigido a determinar la precisión de la TCMC para detectar estenosis coronaria significativa (ECS según puntaje de calcio y frecuencia cardíaca.Material y métodosSe estudiaron 62 pacientes, 50 del sexo masculino, a los que se les realizó primero la coronariografía por TCMC y luego la CI, con una media de 45 días, previo consentimiento informado. Se determinaron la sensibilidad (S, la especificidad (E, el valor predictivo positivo (VPP, el valor predictivo negativo (VPN y la precisión predictiva (PP por paciente y arterias según puntaje de calcio y frecuencia cardíaca.ResultadosLa S, la E, el VPP, el VPN y la PP por arterias fueron, respectivamente, con puntaje de calcio menor o igual a 400 UA del 98%, 98%, 89%, 99% y 98% y con puntaje mayor de 400 UA, del 75%, 50%, 75%, 50% y 67%. En los 54 pacientes con frecuencia cardíaca menor o igual a 65 latidos por minuto, la S, la E, el VPP, el VPN y la PP fueron del 100%, 96%, 96%, 100% y 98,1% y en los 8 pacientes con frecuencia cardíaca mayor de 65 latidos por minuto fueron del 50%, 66,7%, 33%, 80% y 62,5%, respectivamente.ConclusionesEl puntaje de calcio por encima de 400 UA por paciente y arterias, como también la frecuencia cardíaca mayor de 65 latidos por minuto, disminuyen la precisión diagnóstica de ECS a través de la TCMC.

  1. Primera experiencia en el uso de Cardioplejia sanguínea: estudio prospectivo de 200 casos sometidos a Cirugía Cardíaca en el Hospital México, San José, Costa Rica

    Edgar A. Méndez

    2002-12-01

    Full Text Available Introducción: Este estudio reporta la primera experiencia del uso de cardioplejia sanguínea durante la cirugía cardíaca en el hospital México y expone la importancia de su uso en cirugía cardíaca. Material y Métodos: Se estudiaron prospectivamente 200 pacientes consecutivos programados a varios procedimientos quirúrgicos cardíacos con el uso de cardioplejia sanguínea en un período comprendido entre setiembre de 1999 y febrero del 2002. Resultados: Estos 200 casos consistieron de 122 hombres y 78 mujeres con una edad promedio de 57.48 años ( rango, 26 a 28 años . 71 pacientes salieron del arresto cardíaco con ritmo espontáneo. Doce pacientes fallecieron y 30 casos presentaron complicaciones en el postoperatorio: 9 pacientes presentaron infarto agudo al miocardio perioperatorio, 6 casos presentaron para cardiorrespiratorio, 12 tuvieron arritmias cardíacas, 3 pacientes presentaron insuficiencia cardíaca congestivo. Conclusiones: En esta experiencia preliminar, el uso de la cardioplejia sanguínea parece proveer una protección miocárdica segura y confiable durante la cirugía cardíaca, siendo un método ideal en casos de cirugías de elevado riesgo quirúrgico.lntroduction: This study reports the first experience in the use of sanguineous cardioplegia during cardiac surgery in the Mexico Hospital and exposes the important role that this procedure plays in this type of surgery. Materials and Methods: A prospective study was carried out with 200 consecutive patients programmed for different cardiac surgical procedures with the use of sanguineous cardioplegia during the period of September 1999 to February 2002. Results: Of the 200 cases 122 were male and 78 females, all with average ages of 57.48 years. Seventy one patients carne out of cardiac arrest with spontaneous rhythm. Tweive patients died and 30 cases presentes post- surgícal complications: 9 patients presentes acute myocardium infarct, 6 cases presentes Respiratory

  2. Uso crônico e regular de estatina previne fibrilação atrial no pós-operatório de cirurgia cardíaca

    Renato Jorge Alves

    2010-10-01

    Full Text Available FUNDAMENTO: Fibrilação atrial é uma complicação frequente no pós-operatório de cirurgia cardíaca. O uso prévio de estatinas pode reduzir a incidência dessa arritmia. OBJETIVO: Avaliar se o uso crônico e regular de estatina, por um período de seis meses, previne fibrilação atrial no pós-operatório de cirurgia cardíaca eletiva. MÉTODOS: Estudo realizado em 107 pacientes submetidos à cirurgia cardíaca, 66% do sexo masculino e com idade média de 60,4 anos (25 a 84. Avaliou-se a presença de fibrilação atrial entre os pacientes que usavam ou não estatina de forma regular no pré-operatório. Foram excluídos pacientes com cirurgia cardíaca de urgência, insuficiência renal, doenças inflamatórias, fibrilação atrial prévia, portadores de tireoidopatia e aqueles em uso de marca-passo definitivo. RESULTADOS: No período pós-operatório, fibrilação atrial esteve presente em 42 pacientes (39% da amostra, sendo 11 (26% em uso regular de estatina no período pré-operatório e 31 (74% não. Observou-se que, em 22% do total de pacientes em uso de estatina, não houve desenvolvimento de fibrilação atrial, enquanto 45% dos que não usavam estatina apresentaram arritmia (ρ=0,02. Na revascularização miocárdica isolada, 47% dos pacientes que não usavam estatina e 23% dos que usavam desenvolveram fibrilação atrial (ρ =0,02. Não houve diferença estatística significativa na análise dos grupos com ou sem estatina quanto à presença dos fatores de risco para desenvolvimento de fibrilação atrial ( ρ=0,34. CONCLUSÃO: O uso regular de estatina, por seis meses ou mais no período pré-operatório, reduziu a incidência de fibrilação atrial no pós-operatório de cirurgia cardíaca eletiva.

  3. Lesão da artéria ilíaca esquerda durante laminectomia lombar: relato de caso Lesión de la arteria ilíaca izquierda durante laminectomia lombar: relato de caso Left iliac artery injury during lumbar laminectomy: case report

    Wanderley Rodrigues Moreira

    2003-08-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Lesão da artéria ilíaca é uma ocorrência rara em laminectomias, porém, muito grave. O objetivo deste relato é apresentar um caso de lesão da artéria ilíaca esquerda, em paciente submetido a laminectomia lombar sob raquianestesia, que se manifestou clinicamente no pós-operatório imediato, sete horas após o início da cirurgia. RELATO DO CASO: Paciente do sexo masculino, estado físico ASA I, 31 anos, 68 kg, foi submetido à laminectomia lombar em decúbito ventral sob raquianestesia em L2-L3, com bupivacaína hiperbárica a 0,5% (20 mg e fentanil 25 µg. A cirurgia transcorreu normalmente e sete horas após o seu início, já no pós-operatório, o paciente apresentou hipotensão arterial, taquicardia, agitação e dor abdominal difusa. A tomografia abdominal mostrou aspecto compatível com hematoma retroperitoneal e a laparotomia exploradora revelou lesão da artéria ilíaca comum esquerda. Após a laparotomia, o paciente evoluiu bem. CONCLUSÕES: Na dependência do posicionamento e do estado físico, técnicas de anestesia geral se impõem. O caso chama atenção para o fato de que qualquer técnica anestésica que tenha sido realizada, o sangramento no campo operatório pode não ser real, na vigência de uma lesão vascular, porque este sangramento pode ser tardio. No presente caso, a manifestação clínica ocorreu sete horas após o início da cirurgia, quando o paciente já estava recuperado da anestesia. No entanto, o fenômeno (hipotensão arterial poderia ter ocorrido no per-operatório.JUSTIFICATIVA Y OBJETIVOS: Lesión de la arteria ilíaca es una ocurrencia rara en laminectomias, no obstante, muy grave. El objetivo de este relato es presentar un caso de lesión de la arteria ilíaca izquierda, en paciente sometido a laminectomia lombar sobre raquianestesia, que se manifestó clínicamente en el pós-operatorio inmediato, siete horas después del inicio de la cirugía. RELATO DEL CASO: Paciente

  4. 7 CFR 1948.61 - State supplements and guides.

    2010-01-01

    ...) PROGRAM REGULATIONS (CONTINUED) RURAL DEVELOPMENT Section 601 Energy Impacted Area Development Assistance... Public Law 103-354 office). (a) State supplements. State Directors may supplement this subpart...

  5. Physiological strain and countermeasures with firefighting.

    Cheung, S S; Petersen, S R; McLellan, T M

    2010-10-01

    Protective clothing is integral to the task of firefighting, but at the same time can increase physiological strain and impair work capacity. Encapsulation of the head and the high thermal resistance and/or low water vapor permeability of the clothing ensemble impede evaporative heat dissipation, thus elevating the rate of heat storage and creating a state of uncompensable heat stress (UHS). In addition, the additional weight from carrying a supplemental air supply and the greater respiratory work of breathing through a regulator can create a negative spiral of thermal hyperpnea from greater respiratory demands and metabolic heat production. The elevated respiratory demands also increase cardiac strain and potentially the risk for myocardial events. Tolerance time during UHS is determined by three factors: the core temperature at the beginning of the heat stress exposure, the core temperature that can be tolerated before exhaustion or collapse ensues, and the rate of increase in core temperature from the beginning to end of the heat stress exposure. Protective clothing is often employed in highly dynamic environments, making portability, longevity and integration with the task requirements and clothing critical design characteristics for countermeasures. To date, most countermeasures have been relatively indirect in nature, primarily with alterations in work scheduling along with physiological manipulations such as cooling manipulations during recovery periods. Advances are required in materials science to develop lighter and less restrictive protective equipment, concurrent with cooling strategies that target specific regions or which can be effectively implemented during exercise. PMID:21029197

  6. Market Assessment and Product Evaluation of Probiotic Containing Dietary Supplements Available in Bangladesh Market

    Begum, Anjuman Ara; Jakaria, D. M.; Anisuzzaman, Sharif Md; Islam, Mahfuzul; Mahmud, Siraje Arif

    2015-01-01

    Probiotics containing food supplements available in Bangladesh market were identified and collected for assessment. To assess their label claim, they were resuspended into sterile distilled water. Then, series dilutions of each sample solution were prepared and immediately plated out, in duplicate, into De Man Rogosa Sharpe (MRS) agar. These plates were then incubated at 37°C for 48 hours and colonies were counted. Viable cell numbers stated on the labels were compared with actual viable cell numbers. To assess the viability of the probiotics included in the products, probiotic strains were isolated from each of the four products and screened for inhibitory activity against six indicator strains. It was surprisingly found that although the viable cell numbers of all supplements were three to four log cycles lower than label claim of the products, however, this problem did not affect the inhibitory activity of the probiotic strains against indicator strains according to in vitro assessment. Legislation and regulation regarding prebiotic-probiotic containing products should be built up in Bangladesh to ensure quality products supply to the consumers. Moreover, manufacturers of probiotic containing products should take the responsibility for providing the consumer with scientifically and legally correct information. PMID:26649229

  7. Market Assessment and Product Evaluation of Probiotic Containing Dietary Supplements Available in Bangladesh Market

    Anjuman Ara Begum

    2015-01-01

    Full Text Available Probiotics containing food supplements available in Bangladesh market were identified and collected for assessment. To assess their label claim, they were resuspended into sterile distilled water. Then, series dilutions of each sample solution were prepared and immediately plated out, in duplicate, into De Man Rogosa Sharpe (MRS agar. These plates were then incubated at 37°C for 48 hours and colonies were counted. Viable cell numbers stated on the labels were compared with actual viable cell numbers. To assess the viability of the probiotics included in the products, probiotic strains were isolated from each of the four products and screened for inhibitory activity against six indicator strains. It was surprisingly found that although the viable cell numbers of all supplements were three to four log cycles lower than label claim of the products, however, this problem did not affect the inhibitory activity of the probiotic strains against indicator strains according to in vitro assessment. Legislation and regulation regarding prebiotic-probiotic containing products should be built up in Bangladesh to ensure quality products supply to the consumers. Moreover, manufacturers of probiotic containing products should take the responsibility for providing the consumer with scientifically and legally correct information.

  8. Calcium supplements: do they help or harm?

    Manson, Joann E; Bassuk, Shari S

    2014-01-01

    Current recommendations for calcium intake call for 1,000 mg per day for women ages 19-50 and 1,200 mg per day for women over age 50 to ensure bone health. Given recent concerns that calcium supplements may raise risk for cardiovascular disease and kidney stones, women should aim to meet this recommendation primarily by eating a calcium-rich diet and taking calcium supplements only if needed to reach the RDA goal (often only approximately 500 mg per day in supplements is required). PMID:23880796

  9. DNA repair phenotype and dietary antioxidant supplementation

    Guarnieri, Serena; Loft, Steffen; Riso, Patrizia;

    2008-01-01

    of DNA repair incisions were 65.2 (95 % CI 60.4, 70.0) and 86.1 (95 % CI 76.2, 99.9) among the male smokers and well-nourished subjects, respectively. The male smokers also had high baseline levels of oxidised guanines in MNBC. After supplementation, only the male smokers supplemented with slow......-release vitamin C tablets had increased DNA repair activity (27 (95 % CI 12, 41) % higher incision activity). These subjects also benefited from the supplementation by reduced levels of oxidised guanines in MNBC. In conclusion, nutritional status, DNA repair activity and DNA damage are linked, and beneficial...

  10. Quantitative Determination of Vinpocetine in Dietary Supplements.

    French, John M T; King, Matthew D; McDougal, Owen M

    2016-05-01

    Current United States regulatory policies allow for the addition of pharmacologically active substances in dietary supplements if derived from a botanical source. The inclusion of certain nootropic drugs, such as vinpocetine, in dietary supplements has recently come under scrutiny due to the lack of defined dosage parameters and yet unproven short- and long-term benefits and risks to human health. This study quantified the concentration of vinpocetine in several commercially available dietary supplements and found that a highly variable range of 0.6-5.1 mg/serving was present across the tested products, with most products providing no specification of vinpocetine concentrations. PMID:27319129

  11. Guide to mathematical tables supplement no 1

    Burunova, N M; Fedorova, R M

    2014-01-01

    A Guide to Mathematical Tables is a supplement to the Guide to Mathematical Tables published by the U.S.S.R. Academy of Sciences in 1956. The tables contain information on subjects such as powers, rational and algebraic functions, and trigonometric functions, as well as logarithms and polynomials and Legendre functions. An index listing all functions included in both the Guide and the Supplement is included.Comprised of 15 chapters, this supplement first describes mathematical tables in the following order: the accuracy of the table (that is, the number of decimal places or significant

  12. Federal Buildings Supplemental Survey 1993

    NONE

    1995-11-01

    The Energy Information Administration (EIA) of the US Department of Energy (DOE) is mandated by Congress to be the agency that collects, analyzes, and disseminates impartial, comprehensive data about energy including the volume consumed, its customers, and the purposes for which it is used. The Federal Buildings Supplemental Survey (FBSS) was conducted by EIA in conjunction with DOE`s Office of Federal Energy Management Programs (OFEMP) to gain a better understanding of how Federal buildings use energy. This report presents the data from 881 completed telephone interviews with Federal buildings in three Federal regions. These buildings were systematically selected using OFEMP`s specifications; therefore, these data do not statistically represent all Federal buildings in the country. The purpose of the FBSS was threefold: (1) to understand the characteristics of Federal buildings and their energy use; (2) to provide a baseline in these three Federal regions to measure future energy use in Federal buildings as required in EPACT; and (3) to compare building characteristics and energy use with the data collected in the CBECS.

  13. Introduction to tobacco control supplement.

    Chen, Ii-Lun; Husten, Corinne G

    2014-05-01

    Electronic cigarettes (e-cigarettes) have recently gained significant attention in the marketplace and in the media. However, limited information is available about the worldwide impact of e-cigarettes; most public health officials are calling for more data so they can more fully understand the potential risks and benefits of e-cigarettes in order to inform regulatory action. In the USA, e-cigarettes that are marketed as tobacco products are not currently regulated by the Food and Drug Administration (FDA). However, having a continuum of nicotine-containing products that cross jurisdictional lines within the FDA in the future would create the potential (and the need) for a comprehensive nicotine strategy at the FDA. As part of developing the most appropriate approach to e-cigarette regulation, FDA Center for Tobacco Products scientists have been reviewing the available literature to determine the state of e-cigarette knowledge and have identified research areas that could be addressed. This supplement provides a summary of the current knowledge and research gaps pertaining to e-cigarettes with regards to product design, chemistry and toxicology of e-liquid and aerosol constituents, human factor-based risk factors, abuse liability, clinical pharmacology and human health effects, paediatric issues, and environmental issues. PMID:24732156

  14. Controversies in testosterone supplementation therapy

    Mohit Khera

    2015-04-01

    Full Text Available Testosterone has now become one of the most widely used medications throughout the world. The rapid growth of the testosterone market in the past 10 years is due to many factors. We currently have a worldwide aging population. In the US, the number of men 65 years old or older is increasing 2-3 times faster than the number of men younger than 65 years. In addition, poor general health and certain medical conditions such as diabetes/metabolic syndrome (MetS, cardiovascular disease (CVD, and osteoporosis have been associated with low serum testosterone levels. [1],[2],[3] There are now fewer concerns regarding the development of prostate cancer (PCa after testosterone therapy, making it a more attractive treatment option. Finally, the introduction of different forms of testosterone supplementation therapy (TST with increased promotion, marketing, and direct-to-consumer advertising is also driving market growth. As the demand for TST continues to grow, it is becoming more important for clinicians to understand how to diagnose and treat patients with low testosterone.

  15. Novel strained superjunction VDMOS

    Naugarhiya, Alok; Dubey, Shashank; Kondekar, Pravin N.

    2015-09-01

    In this paper, we have proposed novel strained superjunction (s-SJ) vertical double diffused MOS (VDMOS). Through channel engineering, we have introduced strain effects in s-SJ device using thin separate p-type silicon-germanium (p-SiGe) layer over silicon p-pillar. Further, we have designed process flow for the possible fabrication of s-SJ VDMOS. The proposed s-SJ devices fitted with less input capacitance (Cin) and 1.2∼3 times higher output current density than conventional SJ VDMOS. Therefore, 40% less gate charge (Qg) is required to turn-on the s-SJ VDMOS and Ron A is optimized in between 12% and 46%.

  16. Strains in general relativity

    The definition of relative accelerations and strains among a set of comoving particles is studied in connection with the geometric properties of the frame adapted to a 'fiducial observer'. We find that a relativistically complete and correct definition of strains must take into account the transport law of the chosen spatial triad along the observer's congruence. We use special congruences of (accelerated) test particles in some familiar spacetimes to elucidate such a point. The celebrated idea of Szekeres' compass of inertia, arising when studying geodesic deviation among a set of free-falling particles, is here generalized to the case of accelerated particles. In doing so we have naturally contributed to the theory of relativistic gravity gradiometer. Moreover, our analysis was made in an observer-dependent form, a fact that would be very useful when thinking about general relativistic tests on space stations orbiting compact objects like black holes and also in other interesting gravitational situations

  17. Strains in General Relativity

    Bini, Donato; Geralico, Andrea

    2014-01-01

    The definition of relative accelerations and strains among a set of comoving particles is studied in connection with the geometric properties of the frame adapted to a "fiducial observer." We find that a relativistically complete and correct definition of strains must take into account the transport law of the chosen spatial triad along the observer's congruence. We use special congruences of (accelerated) test particles in some familiar spacetimes to elucidate such a point. The celebrated idea of Szekeres' compass of inertia, arising when studying geodesic deviation among a set of free-falling particles, is here generalized to the case of accelerated particles. In doing so we have naturally contributed to the theory of relativistic gravity gradiometer. Moreover, our analysis was made in an observer-dependent form, a fact that would be very useful when thinking about general relativistic tests on space stations orbiting compact objects like black holes and also in other interesting gravitational situations.

  18. Efecto protector de una cepa no virulenta contra la infección con una cepa virulenta de Trypanosoma cruzi en un modelo murino Protective effect of a non virulent strain against infection of a highly virulent strain of Trypanosoma cruzi in a murine model

    C Zúñiga

    2007-01-01

    Full Text Available En el presente estudio se realizó una comparación en el desarrollo de la infección con 2.000 tripomastigotes, en ratones ACA, usando las cepas Tulahuen y Munantá de Trypanosoma cruzi, aisladas originalmente en Chile y Colombia, respectivamente. La cepa ACA se mostró como altamente susceptible a la infección con la cepa Tulahuen, muriendo el 100% de los animales dentro de las 3 semanas postinfección. Sin embargo, todos los ratones infectados con la cepa Munantá sobrevivieron a pesar de alcanzar mayores niveles de parasitemia. El estudio histopatológico de corazón mostró diferentes grados de parasitismo intracelular e infiltrado inflamatorio en relación con la cepa de parásito utilizada. En la infección con la cepa Munantá se pudo observar escasa presencia de pseudoquistes, en este tejido, con una discreta inflamación. Por el contrario, los tejidos de los animales infectados con la cepa Tulahuen mostraron un alto número de parásitos intracelulares y un severo proceso inflamatorio. Se investigó el posible efecto protector de una primoinfección con la cepa no virulenta Munantá frente a una posterior infección con la cepa virulenta Tulahuen. Los animales reinfectados con esta última cepa mostraron menores niveles de parasitemia, 100% de sobrevivencia y menor daño tisular.This study was carried out to compare the infection course of Trypanosoma cruzi in the ACA inbred mouse strain inoculated with 2000 blood trypomastigotes of the Tulahuen strain and the Colombian Munantá strain. Parasitaemia and mortality rates showed different patterns for both strains of the parasite. All the Tulahuen infected mice died within 3 weeks after infection, in contrast, all mice infected with the Munantá strain survived, although they showed higher level of parasitaemia. These results are in agreement with previous findings suggesting poor correlation between death and parasitaemia level. The histopathological study showed different degrees of

  19. Geodetic surveying of strains

    Meixner, H.

    1980-11-01

    This article evaluates methods and apparatus used in the German Democratic Republic to assess vertical and horizontal deformations and strains caused by coal mining and mining of other deposits. Each of the methods is characterized; type of measuring apparatus and its accuracy is given. The following conventional methods of surveying are characterized: (I.) vertical strains: measurement with hydrostatic tube balance (apparatus produced by the Praezisionsmechanik Freiberg, with accuracy of 0.01 mm), trigonometric levelling (error up to 10 mm), geometric levelling (NI 007 and NI 008 apparatus produced by Carl Zeiss JENA), and direct height measuring; (II.) horizontal strains: direct surveying with accuracy higher than 5 mm/50 m, indirect surveying (theodolite THEO 010 A produced by the Carl Zeiss JENA), and alignment method (using apparatus produced by Praezisionsmechanik, Freiberg). Advanced surveying methods are also discussed: electro-optical method (using EOK 2000 range finder produced by Carl Zeiss JENA, with average error ranging from 5 mm to 10 mm), laser method (LF-1 and LFG-1 lasers produced by Carl Zeiss JENA), measuring gyroscope used to measure contorsion (MRK 2 gyroscope produced by the Praezisionsmechanik, Freiberg); photogrammetry: stereophotogrammetry and so-called parallel photogrammetry. (15 refs.) (In Polish)

  20. Adaptive mutations in sugar metabolism restore growth on glucose in a pyruvate decarboxylase negative yeast strain

    Zhang, Yiming; Liu, Guodong; Engqvist, Martin K. M.;

    2015-01-01

    carbon source, and requires supplementation of C2 compounds to the medium in order to meet the requirement for cytosolic acetyl-CoA for biosynthesis of fatty acids and ergosterol. Results: In this study, a Pdc negative strain was adaptively evolved for improved growth in glucose medium via serial......Background: A Saccharomyces cerevisiae strain carrying deletions in all three pyruvate decarboxylase (PDC) genes (also called Pdc negative yeast) represents a non-ethanol producing platform strain for the production of pyruvate derived biochemicals. However, it cannot grow on glucose as the sole...... transfer, resulting in three independently evolved strains, which were able to grow in minimal medium containing glucose as the sole carbon source at the maximum specific rates of 0.138, 0.148, 0.141 h-1, respectively. Several genetic changes were identified in the evolved Pdc negative strains by genomic...

  1. Temperature controlled strain gaged extensometer

    Ramos, G. L.; Seplow, S.

    1968-01-01

    Temperature controlled strain-gaged extensometer measures longitudinal and girth deflections of pressure vessels in excess of one percent strain during pressurization and depressurization with cryogenic fluids at cryogenic temperatures. The device is of beryllium-copper strips.

  2. FY 2014 Supplement to the Presidents Budget

    Networking and Information Technology Research and Development, Executive Office of the President — The annual Supplement to the Presidents Budget for the NITRD Program provides a technical summary of the research activities planned and coordinated through NITRD...

  3. FY 2016 Supplement to the Presidents Budget

    Networking and Information Technology Research and Development, Executive Office of the President — The annual Supplement to the Presidents Budget for the NITRD Program provides a technical summary of the research activities planned and coordinated through NITRD...

  4. FY 2015 Supplement to the Presidents Budget

    Networking and Information Technology Research and Development, Executive Office of the President — The annual Supplement to the Presidents Budget for the NITRD Program provides a technical summary of the research activities planned and coordinated through NITRD...

  5. Sanitary Landfill Supplemental Test Final Report

    This report summarizes the performance of the Sanitary Landfill Supplemental Test data, an evaluation of applicability, conclusions, recommendations, and related information for implementation of this remediation technology at the SRS Sanitary Landfill

  6. Proposed Desert Pupfish Preserve : Supplemental LARC Report

    US Fish and Wildlife Service, Department of the Interior — This document contains supplements to a previous report on the desert pupfish preserve proposal. The attachments are titled: “Vertebrate Animals and Vascular...

  7. Antioxidant supplements for preventing gastrointestinal cancers

    Bjelakovic, G.; Nikolova, D.; Simonetti, R.G.;

    2008-01-01

    BACKGROUND: Oxidative stress may cause gastrointestinal cancers. The evidence on whether antioxidant supplements are effective in preventing gastrointestinal cancers is contradictory. OBJECTIVES: To assess the beneficial and harmful effects of antioxidant supplements in preventing gastrointestinal...... Database from inception to October 2007. We scanned reference lists and contacted pharmaceutical companies. SELECTION CRITERIA: Randomised trials comparing antioxidant supplements to placebo/no intervention examining occurrence of gastrointestinal cancers. DATA COLLECTION AND ANALYSIS: Two authors (GB and...... high. Heterogeneity was low to moderate. Antioxidant supplements were without significant effects on gastrointestinal cancers (RR 0.94, 95% CI 0.83 to 1.06). However, there was significant heterogeneity (I(2) = 54.0%, P = 0.003). The heterogeneity may have been explained by bias risk (low-bias risk...

  8. Dietary Supplements: What You Need to Know

    ... Today's dietary supplements include vitamins, minerals, herbals and botanicals, amino acids, enzymes, and many other products. Dietary ... might reduce the effectiveness of some types of cancer chemotherapy. Keep in mind that some ingredients found ...

  9. 18 CFR 153.11 - Supplemental orders.

    2010-04-01

    ..., OR MODIFY FACILITIES USED FOR THE EXPORT OR IMPORT OF NATURAL GAS Application Under Section 3 § 153... authorization, after opportunity for hearing, such supplemental orders implementing its authority under...

  10. Explanatory supplement to the astronomical almanac

    Urban, Sean E

    2013-01-01

    The Explanatory Supplement to the Astronomical Almanac offers explanatory material, supplemental information and detailed descriptions of the computational models and algorithms used to produce The Astronomical Almanac, which is an annual publication prepared jointly by the US Naval Observatory and Her Majesty's Nautical Almanac Office in the UK. Like The Astronomical Almanac, The Explanatory Supplement provides detailed coverage of modern positional astronomy. Chapters are devoted to the celestial and terrestrial reference frames, orbital ephemerides, precession, nutation, Earth rotation, and coordinate transformations. These topics have undergone substantial revisions since the last edition was published. Astronomical positions are intertwined with timescales and relativity in The Astronomical Almanac, so related chapters are provided in The Explanatory Supplement. The Astronomical Almanac also includes information on lunar and solar eclipses, physical ephemerides of solar system bodies, and calendars, so T...

  11. Tips for Older Dietary Supplement Users

    ... about dietary supplements. These include TV, radio, newspapers, magazines, store clerks, friends, family, or the Internet. It is important to question recommendations from people who have no formal training in nutrition, botanicals, or medicine. While some of these sources, ...

  12. Looks-Conscious Teens Trying Risky Supplements

    ... gov/medlineplus/news/fullstory_159576.html Looks-Conscious Teens Trying Risky Supplements Unregulated products can harm health, ... be role models, but that comes with the power of success and celebrity, he said. "Professional sports ...

  13. MEMS Resonant Strain Sensor Integration

    Myers, David Richard

    2010-01-01

    Despite commercial availability since the 1950's, silicon strain sensors have not experienced the same success as other microdevices, such as accelerometers, pressure sensors, and inkjet heads. Strain sensors measure mechanical deformation and could be used in many structural components, improving safety, controls, and manufacturing tolerances. This thesis examines major strain sensing techniques and highlights both advantages and disadvantages of each. MEMS resonant strain gauges are iden...

  14. Strain calibration of optical FBG-based strain sensors

    Roths, Johannes; Wilfert, Andre; Kratzer, Peter; Jülich, Florian; Kuttler, Rolf

    2010-09-01

    A facility for strain sensitivity calibration of optical FBG-based strain sensors according to the German VDI/VDE 2660 guideline was established and characterized. Statistical analysis of several calibration measurement series performed with one single type of FBG strain sensor and application technique showed a reproducibility of 0.15%. Strain sensitivities for FBGs inscribed in two different types of optical fibres (GF1B and PR2008) showed significantly different strain sensitivities of k = 0.7885+/-0.0026 and k = 0.7758+/-0.0024, respectively.

  15. Oral calcium supplementation in peripartum dairy cows.

    Oetzel, Garrett R

    2013-07-01

    Hypocalcemia in dairy cattle around parturition can be manifest as clinical milk fever or subclinical hypocalcemia. Subclinical hypocalcemia has the greatest economic effect because it affects a much higher proportion of cows. Oral calcium supplements are used to mitigate the effects of both forms of hypocalcemia. Oral calcium supplements are appropriate for cows displaying early clinical signs of hypocalcemia and prophylactically to lessen the negative impacts of hypocalcemia. PMID:23809900

  16. Heavy metals occurrence in Italian food supplements

    Brizio P.; Benedetto A.; Squadrone S.; Tarasco R.; Gavinelli S.; Pellegrino M.; Abete M. C.

    2013-01-01

    In recent years a significant increase in food supplements consumption has been observed, maybe in the belief that they couldn’t be dangerous for consumers health, even if they don’t achieved medical effects. However, environmental pollution can cause heavy metals contamination that could exceed maximum levels established by European legislation. Aim of this work was to evaluate arsenic, cadmium, chromium, lead and mercury content in 12 food supplements seized in a Piedmont shop by the Italia...

  17. Do fat supplements increase physical performance?

    Valentina Di Felice; Felicia Farina; Luigi Rizzuto; Patrizia Catanese; Francesco Carini; Rosario Barone; Filippo Macaluso

    2013-01-01

    Fish oil and conjugated linoleic acid (CLA) belong to a popular class of food supplements known as “fat supplements”, which are claimed to reduce muscle glycogen breakdown, reduce body mass, as well as reduce muscle damage and inflammatory responses. Sport athletes consume fish oil and CLA mainly to increase lean body mass and reduce body fat. Recent evidence indicates that this kind of supplementation may have other side-effects and a new role has been identified in steroidogenensis. Prelimi...

  18. Preparation of food supplements from oilseed cakes

    Sunil, L.; Appaiah, Prakruthi; Prasanth Kumar, P. K.; Gopala Krishna, A. G.

    2014-01-01

    Oilseed cakes have been in use for feed preparation. Being rich in proteins, antioxidants, fibers, vitamins and minerals, oilseed cakes have been considered ideal for food supplementation. These oilseed cakes can be processed and made more palatable and edible by suitable treatments and then incorporated as food supplements for human consumption. Rice bran pellets (RBP), stabilized rice bran (SRB), coconut cake (CC) and sesame cake (SC) were taken up for the study. These were mixed with disti...

  19. Precision determination of strains by strain measurement method

    Method for precision strain measurement determination of strains measurement determination of strains by direct measurement of the resistance of strain gauge resistors put on the sample, by constant current bridge MOD-61 of 0.05 class using a zero method by single bridge double-clamp circuit is described. Strain measurement technique was used to investigate residual stresses in tubular samples. Sample external diameter made up 30 mm, the length - 180, the wall thickness-11 mm. To evaluate the method sensitivity, annealed samples were investigated (annealing temperature-850-880 deg C, hold-up-2 h, cooling in the furnace). It is ascertained, that the method provides for 0.3-0.5 μm strain measurement accuracy even if sample strains do not exceed 3.0-3.6 μm and correspond to residual stress level of no more than 20 MPa

  20. Vitamin D Supplements in the Indian Market.

    Lhamo, Y; Chugh, Preeta Kaur; Tripathi, C D

    2016-01-01

    It is now known that vitamin D deficiency is a worldwide health problem. In our country, as food fortification is lacking, supplementation with pharmaceutical preparations is the only means of treatment of vitamin D deficiency. We aimed to study the composition and availability of various vitamin D preparations in the Indian market, data about which was collected from annual drug compendium. The preparations were assessed for total number, different formulations, constituents and amount of each constituent present in the formulation. Vitamin D3 is available in the form of cholecalciferol, alfacalcidiol and calcitriol as single ingredient products and in combination with calcium and other micronutrients. Most of the supplements contain calcitriol (46.5%) or alfacalcidiol (43%) as tablets (51.1%) and capsules (35.2%). Cholecalciferol, the preferred form for prophylaxis and treatment of vitamin D deficient states, constitutes only 10% of the available market preparations. High market sales of calcium supplements containing calcitriol indicate increasing intake of calcitriol rather than cholecalciferol; which could predispose to toxicity. There is a need for marketing and rational prescribing of the appropriate vitamin D supplement in ostensibly healthy Indian population. Implementation of population-based education and intervention programmes with enforcement of strict regulations could generate awareness and curb unsupervised intake of vitamin D containing dietary supplements. This health challenge mandates effective nutritional policies, fortification and supplementation programmes and partnership between government, healthcare and industry to safeguard the health of Indian population at large. PMID:27168680

  1. Vitamin D Supplements in the Indian Market

    Lhamo, Y.; Chugh, Preeta Kaur; Tripathi, C. D.

    2016-01-01

    It is now known that vitamin D deficiency is a worldwide health problem. In our country, as food fortification is lacking, supplementation with pharmaceutical preparations is the only means of treatment of vitamin D deficiency. We aimed to study the composition and availability of various vitamin D preparations in the Indian market, data about which was collected from annual drug compendium. The preparations were assessed for total number, different formulations, constituents and amount of each constituent present in the formulation. Vitamin D3 is available in the form of cholecalciferol, alfacalcidiol and calcitriol as single ingredient products and in combination with calcium and other micronutrients. Most of the supplements contain calcitriol (46.5%) or alfacalcidiol (43%) as tablets (51.1%) and capsules (35.2%). Cholecalciferol, the preferred form for prophylaxis and treatment of vitamin D deficient states, constitutes only 10% of the available market preparations. High market sales of calcium supplements containing calcitriol indicate increasing intake of calcitriol rather than cholecalciferol; which could predispose to toxicity. There is a need for marketing and rational prescribing of the appropriate vitamin D supplement in ostensibly healthy Indian population. Implementation of population-based education and intervention programmes with enforcement of strict regulations could generate awareness and curb unsupervised intake of vitamin D containing dietary supplements. This health challenge mandates effective nutritional policies, fortification and supplementation programmes and partnership between government, healthcare and industry to safeguard the health of Indian population at large.

  2. Remodelamento ventricular na estimulação cardíaca apical do ventrículo direito Ventricular remodeling in right ventricular apical pacing

    Rodrigo Tavares Silva

    2007-02-01

    Full Text Available OBJETIVO: Avaliar a taxa de remodelamento ventricular (RV e a importância de variáveis clínico-funcionais em pacientes com função cardíaca normal submetidos à estimulação artificial apical do ventrículo direito (VD. MÉTODOS: Dentre 268 pacientes consecutivos com BAVT e marcapasso convencional, foram excluídos os portadores de fração de ejeção do ventrículo esquerdo (FEVE 53 mm ao eco-Doppler. O RV foi definido como o conjunto de modificações ecocardiográficas documentadas pelo menos 6 meses pós-implante: aumento >10% no DDVE e redução > 20% na FEVE. As variáveis analisadas foram: cardiopatia de base, classe funcional de insuficiência cardíaca (IC, tempo de estimulação ventricular e duração do QRS. A análise estatística incluiu os testes da razão de verossimilhança, exato de Fisher e a soma de postos de Wilcoxon. O valor de p foi significante quando OBJECTIVE: To determine ventricular remodeling (VR and the role of clinical and functional variables in patients with normal cardiac function who underwent right ventricular apical pacing (RVAP. METHODS: Among the 268 consecutive patients with standard pacemaker due to complete atrioventricular block (CAVB, those with left ventricular ejection fraction (LVEF 53 mm on Doppler echocardiography were excluded. Ventricular remodeling was defined as echocardiographic changes documented at least six months after implantation, namely, a >10% increase in LVEDD and a > 20% decrease in LVEF. The following variables were analyzed: underlying heart disease, NYHA functional class of heart failure (HF, time of ventricular stimulation, and QRS duration. Statistical analysis included likelihood ratio test, Fisher’s exact test, and Wilcoxon rank-sum test. A p value < 0.05 was considered statistically significant. RESULTS: The study included 75 patients, mean age 70.9 ± 14, of whom 22.6% were male. Mean time between both evaluations was 80.2 months. Before implantation, mean LVEF was

  3. Variabilidad de la frecuencia cardíaca en pacientes con angina inestable: correlación con otros marcadores pronósticos

    Oswaldo Gutiérrez Sotelo

    2004-01-01

    Full Text Available Introducción: La importancia del análisis de la variabilidad de la frecuencia cardíaca (VFC está bien establecida como marcador pronóstico en pacientes que han tenido infarto agudo de miocardio y en otras cardiopatías. El objetivo de este estudio es establecer la correlación entre las variables de VFC y los índices pronósticos tradicionales en angina inestable Materiales y Métodos: Se reclutaron prospectivamente pacientes con diagnóstico de angina inestable. Se consignaron indicadores de riesgo cardiovascular clínicos (angor de reposo refractario, hipotensión arterial, insuficiencia cardíaca, presencia de cambios dinámicos en el ST-T, fracción de eyección =40% y los hallazgos angiográficos (2 ó más vasos, conformándose entonces dos grupos, de alto riesgo y de bajo riesgo. A todos los pacientes se les realizó un registro electrocardiográfico de 5 minutos y se analizaron diversas variables de VFC en dominio de tiempo y de frecuencia mediante un programa de computadora. Estas variables se compararon entre ambos grupos. Resultados: Se reclutaron 63 pacientes (44 hombres, 70% con edad promedio de 63 + 10.4 años (35-90; 46 se consideraron de alto riesgo por cambios electrocardiográficos dinámicos y la fracción de eyección disminuida y 17 de bajo riesgo. En el primer grupo, el poder espectral total fue significativamente menor que en el grupo de bajo riesgo (p=0.04. La banda de baja frecuencia mostró diferencia pero sin alcanzar significancia estadística (p=0.07 y otras variables como el SDNN, el NN50 y la banda de baja frecuencia, mostraron sólo tendencia de ser menores en el grupo de alto riesgo. Conclusión: En pacientes con angina inestable de alto riesgo, la presencia de indicadores pronósticos tiene correlación con una menor VFC en dominio de frecuencia.Introduction: The usefullness of heart rate variability (HRV analysis is well known in myocardial infarction as in other cardiac diseases as a prognostic tool. The

  4. Insuficiência cardíaca: comparação entre o teste de caminhada de seis minutos e o teste cardiopulmonar

    Eduardo Elias Vieira de Carvalho

    2011-07-01

    Full Text Available FUNDAMENTO: A insuficiência cardíaca crônica (IC é uma síndrome complexa caracterizada pela redução do débito cardíaco em relação às necessidades metabólicas do organismo, bem como alterações metabólicas e do eixo neuro-hormonal. Sintomas como fadiga muscular e dispneia são notórios e os testes de esforço são amplamente utilizados para a avaliação da capacidade funcional, prognóstico e eficácia das intervenções terapêuticas nessa síndrome. OBJETIVO: Avaliar a reprodutibilidade do teste de caminhada de seis minutos (TC6' em pacientes com IC e correlacionar a magnitude das variáveis atingidas no pico do esforço do TC6' com as de um teste cardiopulmonar (TCP. MÉTODOS: Foram estudados 16 pacientes (12 homens e 4 mulheres com diagnóstico de IC CF I-II (NYHA. Os voluntários foram submetidos a dois testes TC6' (TC6'1 e TC6'2 com intervalo de 30 minutos entre eles; posteriormente realizaram um TCP máximo. RESULTADOS: Todas as variáveis obtidas nos dois TC6' mostraram-se significantes, com altas correlações: distância percorrida (DP (r = 0,93; p < 0,0001, frequência cardíaca (FC (r = 0,89; p < 0,0001, consumo de oxigênio (VO2 (r = 0,93; p < 0,0001 e escala de percepção de esforço (r = 0,85; p < 0,0001. Por sua vez, todas as variáveis analisadas no TC6' mostraram correlações moderadas e significantes com as variáveis obtidas no TCP, a saber: FC pico (r = 0,66; p = 0,005; VO2 (r = 0,57; p = 0,02 e VO2 no TCP e DP no TC6'2 (r = 0,70; p = 0,002. CONCLUSÃO: O TC6' foi reprodutível nesse grupo de pacientes com IC (NYHA - I-II e se correlacionou com o TCP. Sendo assim, apresenta-se como ferramenta de avaliação fidedigna, constituindo-se numa alternativa adequada, segura e de baixo custo para a prescrição de exercícios físicos aeróbicos em pacientes com IC.

  5. Spectral analysis of cardiac rate variability Análisis espectral de la variabilidad de la frecuencia cardíaca

    Diego Luis Alvarez Montoya

    1999-02-01

    Full Text Available In the last years relationship between autonomic nervous system (ANS function and cardiovascular mortality has been recognized. This has motivated research to find quantitative markers of autonomic balance. Heart rate variability (HRV is one of the most promising methods. HRV is defined as the variations occurred in the time interval between consecutive heartbeats and it is thought to depend on the ANS modulation. Tacogram (recording of cardiac frequency in time is used to evaluate HRV. The study of HRV started 30 years ago and has gained importance in the last 10 years. There are several methods to evaluate HRV. The most accepted today are frequency domain methods (spectral analysis. Spectral analysis consists in the decomposition in order to obtain the spectral components. There are high frequency components (HF, related to vagal tone, low frequency (LF components, related to the modulation of both sympathetic and vagal modulation, and very low frequency components which have not been related to any physiological variable. Time domain methods, are basically statistic and evaluate variability using means and standard deviations. These methods seem to have less advantages than spectral methods. HRV is correlated with physiological adaptations to changes in internal and external environment and to the presence of diseases. This article presents the main techniques in the time and frequency domains and their relationship with physiological changes and specific diseases. En los últimos años, se ha reconocido la relación existente entre el funcionamiento del sistema nervioso autónomo (SNA y la mortalidad cardiovascular. Esto ha motivado la búsqueda de marcadores cuantitativos del balance autonómico. La Variabilidad de la Frecuencia Cardíaca (VFC representa uno de los más promisorios. La VFC se define como la variación que ocurre en el intervalo de tiempo entre latidos consecutivos y se ha propuesto que su comportamiento depende de la

  6. Experiência inicial com operações cardíacas minimamente invasivas Initial experience with minimally invasive cardiac operations

    Francisco Costa

    2012-09-01

    Full Text Available INTRODUÇÃO: Operações cardíacas minimamente invasivas têm sido propostas como uma alternativa para a correção de diversas cardiopatias congênitas e adquiridas, com o intuito de reduzir a morbimortalidade. OBJETIVOS: Descrever a experiência inicial de dois anos com operações cardíacas minimamente invasivas, com ênfase nos aspectos técnicos e na curva de aprendizado. MÉTODOS: Entre julho de 2009 a março de 2012, 95 pacientes foram operados com técnicas minimamente invasivas. A média de idade foi de 55±15 anos e 53% pacientes eram do sexo feminino. As operações foram fechamento de comunicação interatrial (25, substituição valvar aórtica (32, plastia mitral (23, substituição valvar mitral (12, ressecção de mixoma de átrio esquerdo (2 e ressecção de membrana subaórtica (1. A incisão consistiu de minitoracotomia lateral direita em 87 casos e de miniesternotomia em oito. RESULTADOS: A mortalidade imediata foi de 4,2%, e o tamanho médio da incisão foi de 6,3 ± 1,2 cm. A extensão da toracotomia só foi necessária em um caso. Dois pacientes apresentaram acidente vascular cerebral, e a quantidade total de sangramento foi de 470 ± 277 ml. Nenhum paciente teve infecção de ferida operatória, e 67% dos casos não apresentaram morbidade pós-operatória significativa. CONCLUSÕES: Os resultados iniciais com operações minimamente invasivas demonstraram que elas podem ser realizadas de forma segura e com resultados iniciais satisfatórios. O índice de satisfação dos pacientes foi elevado. Uma vez ultrapassada a curva de aprendizado, as operações minimamente invasivas podem ser uma excelente alternativa para muitos pacientes com cardiopatias valvares e congênitas.BACKGROUND: Minimally invasive cardiovascular operations have been proposed as an alternative method to correct several cardiac congenital and acquired heart diseases, with the aim to reduce morbidity and mortality. OBJECTIVES: Describe the two years

  7. Application of 99mTechnetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) SPECT/CT in prostate cancer patients

    Rationale: The peptide bombesin (BBN) and its derivatives exhibit high binding affinity for the gastrin-releasing peptide receptor (GRPR), which is highly expressed in prostate cancer. We used the BBN-based radiopharmaceutical 99mTechnetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) (99mTc-HABBN) to perform a first-in-man clinical pilot study to evaluate the feasibility of 99mTc-HABBN SPECT/CT for detection of prostate cancer in patients. Methods: Eight patients with biopsy-proven prostate cancer who were scheduled for either radical prostatectomy or external beam radiotherapy underwent 99mTc-HABBN scintigraphy and SPECT/CT prior to treatment. Serial blood samples were taken to assess blood radioactivity and to determine in vivo metabolic stability. Clinical parameters were measured and reported side effects, if present, were recorded. Prostate cancer specimens of all patients were immunohistochemically stained for GRPR. Results: 99mTc-HABBN was synthesized with high radiochemical yield, purity and specific activity. There were no significant changes in clinical parameters, and there were no adverse or subjective side effects. Low metabolic stability was observed, as less than 20% of 99mTc-HABBN was intact after 30 min. Immunohistochemical staining for GRPR was observed in the prostate cancer specimens in all patients. 99mTc-HABBN scintigraphy and SPECT/CT did not detect prostate cancer in patients with proven disease. Conclusions: 99mTc-HABBN SPECT/CT for visualization of prostate cancer is safe but hampered by an unexpected low in vivo metabolic stability in man. The difference between the excellent in vitro stability of 99mTc-HABBN in human serum samples determined in our previous study regarding 99mTc-HABBN and the low in vivo metabolic stability determined in this study, is striking. This issue warrants further study of peptide-based radiopharmaceuticals

  8. Influencia de la madurez sexual y la castración sobre la actividad eléctrica cardíaca en conejos machos y hembras

    Gabriela Y. Eizikovits

    2010-08-01

    Full Text Available Es bien conocida la existencia de diferencias en la actividad eléctrica cardíaca asociadas al sexo. Si bien estas diferencias habitualmente se relacionan al efecto de la madurez y de las hormonas sexuales gonadales, todavía existen controversias al respecto. El objetivo de este trabajo fue evaluar el efecto que la madurez sexual y la castración producen sobre los distintos parámetros del electrocardiograma de superficie y de la duración de los potenciales de acción (DPA. Se utilizaron conejos jóvenes (menores de un mes de edad y adultos (mayores de seis meses de edad. Las diferencias obtenidas en las hembras se observan en la repolarización tardía, mientras que en los machos ocurren en la repolarización temprana. Existiría una relación entre las diferencias observadas en la duración desde el pico máximo hasta el fin de la onda T (Tpf y las observadas en la DPA al 90% de la repolarización (DPA90 en las hembras, mientras que en los machos la relación existe entre la duración desde el punto J hasta el pico máximo de la onda T (JTp y la DPA al 30 y 50% de la repolarización (DPA30 y DPA50. Si bien existen diferencias que podrían ser debidas a factores hormonales otras serían debidas a factores no hormonales.

  9. Avaliação da carga de trabalho no pós-operatório de cirurgia cardíaca segundo o Nursing Activities Score

    Larissa Bertacchini de Oliveira

    2015-12-01

    Full Text Available RESUMO Objetivo Identificar os fatores associados à carga de trabalho de enfermagem no cuidado a pacientes no pós-operatório de cirurgia cardíaca. Método Estudo de coorte prospectivo, conduzido com 187 pacientes da Unidade de Terapia Intensiva Cirúrgica (UTI do Instituto do Coração. Os dados foram coletados nas primeiras 24 e 72 horas do paciente na UTI. A variável dependente foi a carga de trabalho calculada por meio do Nursing Activities Score (NAS e as independentes foram de natureza demográfico-clínicas e escores de morbimortalidade. Para análise dos dados utilizou-se os testes de Wilcoxon-Mann-Whitney e de correlação de Spearman, e a regressão linear com modelo de efeitos mistos. Resultados A maioria dos pacientes era do sexo masculino (59,4%, com média de idade de 61 anos (±12,7 e 43,9% desenvolveram algum tipo de complicação no pós-operatório. Nas 24 horas, a carga de trabalho foi de 82,4% (±3,4 e foi de 58,1% (±3,4 nas 72 horas. Os fatores associados ao aumento do NAS foram: tempo de internação do paciente na UTI (p=0,036 e a presença de complicações (p<0,001. Conclusão A gravidade do paciente nas 24 horas, em oposição a inúmeros estudos, não influenciou no aumento da carga de trabalho, a qual se mostrou associada ao tempo de internação e às complicações.

  10. Enfermedad celíaca del adulto: aspectos endocrinológicos y nutricionales Adult celiac disease: endocrinological and nutritional issues

    D. Peteiro-González

    2010-10-01

    Full Text Available La enfermedad celíaca es una enteropatía autoinmune que aparece como respuesta a la ingesta de gluten en sujetos genéticamente predispuestos. Aunque históricamente se la ha considerado una patología pediátrica e infrecuente su prevalencia está próxima al 1% de la población general, siendo todavía más elevada en pacientes con determinadas patologías endocrinológicas y déficits nutricionales. El empleo de los anticuerpos antitransglutaminasa y antiendomisio y la endoscopia digestiva con toma de biopsia serán elementos clave para su diagnóstico. La instauración de una dieta sin gluten logrará la recuperación del trofismo intestinal y evitará el riesgo de complicaciones a largo plazo a la vez que mejora la calidad de vida del paciente. El seguimiento médico y nutricional será clave para lograr una buena adherencia terapéutica.Celiac disease is an autoinmune enterophaty induced by the ingestion of gluten in genetically susceptible individuals. Although historically it was thought that it was an infrequent pediatric disease, now it is know that its prevalence is close to 1% in the general population. It is even higher between patients with some endocrine disorders and nutritional deficits. The use of antitransglutaminase and antiendomisium antibodies and the endoscopical duodenal biopsy are the cornerstones for its diagnosis. The introduction of a gluten-free diet will achieve the normalization of the intestinal mucosa. It will avoid the risk of long term complications and an it will achieve an improvement in quality of life. Medical and dietitian long term follow-up will be important to improve the compliance to the treatment.

  11. Influência da suplementação de creatina na capacidade funcional de pacientes com Insuficiência Cardíaca

    Ana Paula Perillo Ferreira Carvalho

    2012-07-01

    Full Text Available FUNDAMENTO: A Insuficiência Cardíaca (IC é uma síndrome complexa, marcada pela intolerância ao esforço e perda da capacidade funcional. OBJETIVO: Avaliar a capacidade funcional dos pacientes com IC suplementados com creatina. MÉTODOS: Estudo prospectivo, randomizado, duplo cego. Foram randomizados em dois grupos 33 pacientes com IC, com idade > 18 anos, sexo masculino, classes funcionais II a IV. O grupo experimental (G CRE, n = 17 foi suplementado com creatina com dose de 5 g por dia durante seis meses. E o grupo placebo (G PLA, n = 16 recebeu 5 g de maltodextrina por dia durante o mesmo período de tempo. Ambos os grupos foram submetidos a avaliação da capacidade funcional por meio da ergoespirometria e teste de caminhada de seis minutos (TC6 pré e pós-intervenção. O modelo estatístico Ancova e a correlação de Pearson foram utilizados na análise dos grupos e nas formas de tratamento. RESULTADOS: Das variáveis avaliadas na ergoespirometria, o volume de oxigênio pico (VO2 pico, limiar anaeróbio (LA e o pulso de oxigênio (pulso de O2 não apresentaram diferenças significativas entre os grupos (P>0,05. No TC6 não houve diferença significativa na distância percorrida. CONCLUSÃO: A suplementação de creatina em pacientes com IC não promoveu melhora significativa na capacidade funcional.

  12. Development of reversible strain gage

    A high-temperature strain gage which can be peeled after taking required apparent strain measurements in a furnace and can be attached reverse-side-up at the point of interest on a test structure was developed. Using the ''reversible'' strain gage with selected room-temperature curing type polyester adhesive, one can expect to measure thermal strain accurately, especially for on large structures, at the first test in temperature up to 250 deg C. The repeatability of apparent strains for about 100 reversible gages was within 50 microstrains of difference at 250 deg C (within 30 microstrains of difference for 80 % of the test gages). (author)

  13. [Echinococcus and strain concepts].

    Utük, Armağan Erdem; Simsek, Sami

    2008-01-01

    Hydatid disease (echinococcosis) is one of the most important parasitic zoonoses and remains a public health and economic problem all over the world. Echinococcus granulosus includes a number of genetic variants and, up to date, analyses of mitochondrial DNA sequences have identified ten distinct genetic types (genotypes G1-10). This categorization follows closely the pattern of strain variation emerging based on biological characteristics. The extensive variation in E. granulosus may influence life-cycle patterns, host specificity, development rate, antigenicity, transmission dynamics, sensitivity to chemotherapeutic agents, and pathology. In this review, the recent genetic characterizations of Echinococcus genus have been summarized. PMID:18351549

  14. Asymptomatic bacteriuria Escherichia coli strains

    Hancock, Viktoria; Nielsen, E.M.; Klemm, Per

    2006-01-01

    Urinary tract infections (UTIs) affect millions of people each year. Escherichia coli is the most common organism associated with asymptomatic bacteriuria (ABU) in humans. Persons affected by ABU may carry a particular E. coli strain for extended periods of time without any symptoms. In contrast to...... uropathogenic E. coli (UPEC) that cause symptomatic UTI, very little is known about the mechanisms by which these strains colonize the urinary tract. Here, we have investigated the growth characteristics in human urine as well as adhesin repertoire of nine ABU strains; the ability of ABU strains to compete...... against the UPEC strain CFT073 was also studied. The different ABU strains displayed a wide variety of the measured characteristics. Half of the ABU strains displayed functional type 1 fimbriae while only one expressed functional P fimbriae. A good correlation between the growth rate of a particular...

  15. [Evolution of the origin of strain of Shancigu (Rhizoma Pleionis)].

    Li, Guangyan; Song, Xiangwen; Han, Bangxing; Fang, Shiying

    2015-05-01

    Shancigu (Rhizome Pleionis) was first recorded in the Ben cao shiyi (Supplements to Chinese Materia Medica). The source of the strain of this medicinal was unclear because of its too simple description in the medical books in the Tang and Song dynasties. Its original plant could be Cremastra appendiculata (D.Don) Makino, Tulipa edulis (Miq.) Baker and so on. The original plant of Shanciguwas Tulipaedulis since the Ming dynasty to the Republican period. The name of "Guangcigu" began to appear in the Republican period because of the changes of its processing method. The original plants evolved into Cremastra appendiculata, Pleione bulbocodioides (Franch.) Rolfe and Pleione yunnanensis Rolfe, with Tulipa edulisas the original plant of Guangcigu (Bulbus of Tulipasedulis). It is found that only the Tulipaedulis is the unequivocal origin with the longest medicinal history through sorting out of the original plants of Shancigu. Hence, it is suggested that Tulipa edulis should be recovered as the original strain of Shancigu. PMID:26420522

  16. Reconstruction of axisymmetric strain distributions via neutron strain tomography

    Predicting the behaviour of structural components under a particular set of loading conditions requires knowledge of the residual elastic strain distribution throughout the bulk of these components. Characterising the 3D strain state at any particular point involves the measurement of six independent components which make up the second order strain tensor. Mapping the complete strain distribution throughout large volumes thus presents significant practical challenges. One possible solution to this problem is to reconstruct the 3D variation of strain components using tomographic techniques. The basic principle underpinning this idea is that the multi-component strain tensor can be reconstructed from a redundant set of lower order projection data. Here we demonstrate this fundamental concept for two samples: a shrink fit ‘ring-and-plug’ sample, and a spray-quenched circular cylinder, both possessing axially symmetric internal strain distribution. We present and contrast different approaches to the strain tomography problem. The methods described here can also be readily applied to high-energy X-ray diffraction measurements and represent an important step toward developing the tomographic reconstruction framework for strain tensor distributions of arbitrary complexity. The major benefit of neutron strain tomography is that the incident beam flux is utilised more fully, greatly reducing the data collection times. Using micro-channel plate (MCP) neutron detectors, a spatial resolution of the order of 0.1 mm can be achieved .

  17. Cyclic strain-induced endothelial MMP-2: role in vascular smooth muscle cell migration

    Matrix metalloproteinases (MMPs) play a vital role in vasculature response to hemodynamic stimuli via the degradation of extracellular matrix substrates. In this study, we investigated the putative role of cyclic strain-induced endothelial MMP-2 (and MMP-9) expression and release in modulating bovine aortic smooth muscle cell (BASMC) migration in vitro. Equibiaxial cyclic strain of bovine aortic endothelial cells (BAECs) leads to elevation in cellular MMP-2 (and MMP-9) expression, activity, and secretion into conditioned media, events which were time- and force-dependent. Subsequent incubation of BASMCs with conditioned media from chronically strained BAECs (5%, 24 h) significantly reduces BASMC migration (38 ± 6%), an inhibitory effect which could be completely reversed by targeted siRNA 'knock-down' of MMP-2 (but not MMP-9) expression and activity in BAECs. Moreover, inhibition of strain-mediated MMP-2 expression in BAECs by protein tyrosine kinase (PTK) blockade with genistein (50 μM) was also found to completely reverse this inhibitory effect on BASMC migration. Finally, direct supplementation of recombinant MMP-2 into the BASMC migration assay was found to have no significant effect on migration. However, the effect on BASMC migration of MMP-2 siRNA transfection in BAECs could be reversed by supplementation of recombinant MMP-2 into BAEC media prior to (and for the duration of) strain. These findings reveal a potentially novel role for strain-induced endothelial MMP-2 in regulating vascular SMC migration

  18. FDA vs. Ephedra: Dietary Supplement Regulation Under DSHEA

    Jones, Adam R.

    2002-01-01

    The Dietary Supplement Health and Education Act of 1994 (DSHEA) dramatically changed the way dietary supplements are regulated in the United States. DSHEA created a new category of products defined as “dietary supplements,†and altered the way in which these products are regulated in an attempt to promote consumer access to dietary supplements. By weakening the FDA’s regulatory control of dietary supplements, DSHEA made it impossible for the F...

  19. Functional Feed Assessment on Litopenaeus vannamei Using 100% Fish Meal Replacement by Soybean Meal, High Levels of Complex Carbohydrates and Bacillus Probiotic Strains

    Rosalia Contreras

    2011-06-01

    Full Text Available Functional feed supplemented with alternative-economic nutrient sources (protein, carbohydrates, lipids and probiotics are being considered in shrimp/fish aquaculture production systems as an option to increase yield and profits and to reduce water pollution. In this study the probiotic potential to formulate functional feeds have been evaluated using four dietary treatments: Treatment 1 (B + Bs; Bacillus subtilis potential probiotic strain was supplemented to a soybeanmeal (SBM—carbohydrates (CHO basal feed. Treatment 2 (B + Bm; Bacillus megaterium potential probiotic strain was supplemented to the same SBM-CHO basal feed. In Treatment 3 (B; SBM-CHO basal feed was not supplemented with probiotic strains. Treatment 4 (C; fishmeal commercial feed (FM was utilized as positive control. Feeding trials evaluated the survival, growth, and food conversion ratio and stress tolerance of juvenile Litopenaeus vannamei (Boone Pacific white shrimp. Best overall shrimp performance was observed for animals fed with Treatment 1 (B+Bs; additionally, stress tolerance and hemolymph metabolites also showed the best performance in this treatment. SBM-CHO basal feed not supplemented with probiotic strains (B presented smaller growth and lower feed conversion ratio (FCR. Shrimps fed with the fishmeal commercial feed (C presented the lowest stress tolerance to high ammonia and low oxygen levels. Specifically selected B. subtilis strains are recommended to formulate functional and economical feeds containing high levels of vegetable; protein and carbohydrates as main dietary sources in L. vannamei cultures.

  20. Functional feed assessment on Litopenaeus vannamei using 100% fish meal replacement by soybean meal, high levels of complex carbohydrates and Bacillus probiotic strains.

    Olmos, Jorge; Ochoa, Leonel; Paniagua-Michel, Jesus; Contreras, Rosalia

    2011-01-01

    Functional feed supplemented with alternative-economic nutrient sources (protein, carbohydrates, lipids) and probiotics are being considered in shrimp/fish aquaculture production systems as an option to increase yield and profits and to reduce water pollution. In this study the probiotic potential to formulate functional feeds have been evaluated using four dietary treatments: Treatment 1 (B + Bs); Bacillus subtilis potential probiotic strain was supplemented to a soybeanmeal (SBM)-carbohydrates (CHO) basal feed. Treatment 2 (B + Bm); Bacillus megaterium potential probiotic strain was supplemented to the same SBM-CHO basal feed. In Treatment 3 (B); SBM-CHO basal feed was not supplemented with probiotic strains. Treatment 4 (C); fishmeal commercial feed (FM) was utilized as positive control. Feeding trials evaluated the survival, growth, and food conversion ratio and stress tolerance of juvenile Litopenaeus vannamei (Boone) Pacific white shrimp. Best overall shrimp performance was observed for animals fed with Treatment 1 (B+Bs); additionally, stress tolerance and hemolymph metabolites also showed the best performance in this treatment. SBM-CHO basal feed not supplemented with probiotic strains (B) presented smaller growth and lower feed conversion ratio (FCR). Shrimps fed with the fishmeal commercial feed (C) presented the lowest stress tolerance to high ammonia and low oxygen levels. Specifically selected B. subtilis strains are recommended to formulate functional and economical feeds containing high levels of vegetable; protein and carbohydrates as main dietary sources in L. vannamei cultures. PMID:21747750

  1. Uso da radiofrequência bipolar para o tratamento da fibrilação atrial durante cirurgia cardíaca Uso de la radiofrecuencia bipolar para el tratamiento de la fibrilación atrial durante cirugía cardíaca Use of bipolar radiofrequency for the treatment of atrial fibrillation during cardiac surgery

    Leonardo Secchin Canale

    2011-06-01

    Full Text Available FUNDAMENTO: O tratamento da fibrilação atrial com dispositivo de ablação de tecidos por radiofrequência bipolar em concomitância à cirurgia cardíaca tem se mostrado método eficaz no tratamento desta arritmia. OBJETIVO: Descrever a experiência inicial do Instituto Nacional de Cardiologia no tratamento cirúrgico da fibrilação atrial com uso de dispositivo de radiofrequência bipolar em pacientes submetidos à cirurgia cardíaca, relatando o resultado de acompanhamento pós-operatório de um ano. MÉTODOS: Entre janeiro de 2008 e março de 2009, 47 pacientes (36 mulheres consecutivos, com idade média de 53,7 ± 10,6 anos, apresentando fibrilação atrial por um período médio de 34,6 meses (3 a 192 meses foram submetidos à ablação cirúrgica desta arritmia, por radiofrequência bipolar, durante o procedimento que motivou a indicação da cirurgia. Oito apresentavam fibrilação atrial intermitente e 39, contínua. Oitenta e um por cento foram submetidos à cirurgia valvar como procedimento principal. Esta é uma análise retrospectiva, observacional, com avaliação de um ano de pós-operatório das variáveis clínicas e de Holter 24 h. RESULTADOS: Dos 47 pacientes, 40 sobreviveram um ano. Desses, 33 foram submetidos a Holter 24 h, em um intervalo médio de 401 dias após a cirurgia. Encontrou-se a seguinte distribuição de ritmos: 24 (73% sinusal, 5 (15% fibrilação atrial, três (9% Flutter atrial e um (3% ritmo juncional. Foram observados dois acidentes vasculares encefálicos, sendo um associado à arritmia supraventricular. CONCLUSÃO: A ablação cirúrgica de fibrilação atrial com dispositivo de radiofrequência bipolar concomitante à cirurgia cardíaca é método eficaz para o tratamento desta arritmia.FUNDAMENTO: El tratamiento de la fibrilación atrial con dispositivo de ablación de tejidos por radiofrecuencia bipolar en concomitancia con la cirugía cardíaca se muestra un método eficaz en el tratamiento de esta

  2. Effects of creatine supplementation in taekwondo practitioners

    Rafael Manjarrez-Montes de Oca

    2013-04-01

    Full Text Available Introduction: Taekwondo (TKD is a combat sport, which has also been proposed as a fitness program, with a strong anaerobic component. Creatine (Cr supplementation is used to improve both anaerobic exercise performance and body composition. Therefore, Cr supplementation could be beneficial in TKD. Aims: To determine the effect of Cr supplementation (50 mg/kg body wt on body composition, anaerobic power and blood chemistry in young male TKD practitioners. Methods: Ten male TKD practitioners (age [20 ± 2 yr], height [1.69 ± 0.06 m], and mass [67 ± 9.8 kg] participated in a placebo-controlled, double blind, crossover study. Body composition (DEXA, anaerobic power (Wingate Test, blood lactate and blood chemistry were measured before and after supplementation. Differences between data before and after supplementation were calculated for each treatment (Cr and Placebo and were compared using the Wilcoxon signed-rank test. Results: Fat mass (kg decreased after placebo (Mdn [IqR] = -0.75 [-1.44 to 0.03] and increased following Cr intake (0.17 [-0.77 to 1.13] kg (Z = 2.191, p < 0.028, r = 0.49. Serum triglyceride concentration (mg/mL increased after Cr (45.00 [-7.50 to 75.00] and decrease with placebo (-7.00 [-10.75 to 12.00] (Z = 2.090, p < 0.037, r = 0.47. No changes were found in others parameters. Conclusion: Cr supplementation may increase fat mass and serum triglycerides concentration in young male TKD practitioners without improvement in anaerobic power. Cr supplementation appears to be safe, but athletes should be careful when they want to loss fat.

  3. The Box H/ACA snoRNP Assembly Factor Shq1p is a Chaperone Protein Homologous to Hsp90 Cochaperones that Binds to the Cbf5p Enzyme

    Godin, Katherine S.; Walbott, Helene; Leulliot, Nicolas; van Tilbeurgh, Herman; Varani, Gabriele

    2009-05-06

    Box H/ACA small nucleolar (sno) ribonucleoproteins (RNPs) are responsible for the formation of pseudouridine in a variety of RNAs and are essential for ribosome biogenesis, modification of spliceosomal RNAs, and telomerase stability. A mature snoRNP has been reconstituted in vitro and is composed of a single RNA and four proteins. However, snoRNP biogenesis in vivo requires multiple factors to coordinate a complex and poorly understood assembly and maturation process. Among the factors required for snoRNP biogenesis in yeast is Shq1p, an essential protein necessary for stable expression of box H/ACA snoRNAs. We have found that Shq1p consists of two independent domains that contain casein kinase 1 phosphorylation sites. We also demonstrate that Shq1p binds the pseudourydilating enzyme Cbf5p through the C-terminal domain, in synergy with the N-terminal domain. The NMR solution structure of the N-terminal domain has striking homology to the ‘Chord and Sgt1’ domain of known Hsp90 cochaperones, yet Shq1p does not interact with the yeast Hsp90 homologue in vitro. Surprisingly, Shq1p has stand-alone chaperone activity in vitro. This activity is harbored by the C-terminal domain, but it is increased by the presence of the N-terminal domain. These results provide the first evidence of a specific biochemical activity for Shq1p and a direct link to the H/ACA snoRNP.

  4. Papel da titina na modulação da função cardíaca e suas implicações fisiopatológicas

    Ricardo Castro-Ferreira

    2011-04-01

    Full Text Available A titina é uma proteína sarcomérica gigante que se estende desde a linha Z até a linha M. Em razão de sua localização, representa um importante sensor biomecânico com um papel fundamental na manutenção da integridade estrutural do sarcômero. A titina funciona como uma "mola bidirecional" que regula o comprimento sarcomérico e realiza ajustes adequados da tensão passiva sempre que o comprimento varia. Dessa forma, não só determina a rigidez ventricular e a função diastólica, como também influencia a função cardíaca sistólica, modulando o mecanismo de Frank-Starling. O miocárdio expressa duas isoformas dessa macromolécula: a N2B, mais rígida, e a isoforma N2BA, mais complacente. As alterações na expressão relativa das duas isoformas da titina ou alterações do seu estado de fosforilação têm sido implicadas na fisiopatologia de várias doenças como a insuficiência cardíaca diastólica, a cardiomiopatia dilatada, a cardiomiopatia isquêmica e a estenose aórtica. Neste artigo pretende-se descrever sumariamente a estrutura e localização da titina, a sua relação com diferentes cardiomiopatias, e compreender de que forma as alterações dessa macromolécula influenciam a fisiopatologia da insuficiência cardíaca diastólica, salientando o potencial terapêutico da manipulação dessa macromolécula.

  5. Salmon Supplementation Studies in Idaho Rivers (Idaho Supplementation Studies) : Experimental Design, 1991 Technical Report.

    Bowles, Edward C.; Leitzinger, Eric J.

    1991-12-01

    The purpose of this study is to help determine the utility of supplementation as a potential recovery tool for decimated stocks of spring and summer chinook salmon in Idaho. The goals are to assess the use of hatchery chinook to restore or augment natural populations, and to evaluate the effects of supplementation on the survival and fitness of existing natural populations.

  6. O ecocardiograma na terapia de ressincronização cardíaca El ecocardiograma en la terapia de resincronización cardiaca Echocardiography in cardiac resynchronization therapy

    Viviane Cordeiro Veiga

    2009-10-01

    Full Text Available A terapia de ressincronização cardíaca (TRC tem sido uma opção efetiva nos pacientes com insuficiência cardíaca avançada. No entanto 20% a 30% dos pacientes não apresentam benefícios nessa terapêutica. Critérios clínicos, eletrocardiográficos e ecocardiográficos têm sido estudados na tentativa de selecionar os pacientes que serão beneficiados com a ressincronização cardíaca, mas o ecocardiograma tem papel importante tanto na seleção quanto na avaliação e otimização dessa terapêutica. O objetivo desta revisão é descrever os principais parâmetros ecocardiográficos utilizados na avaliação da terapia de ressincronização cardíaca.La terapia de resincronización cardiaca (TRC viene siendo una opción efectiva en los pacientes con insuficiencia cardiaca avanzada. Sin embargo, del 20% al 30% de los pacientes no presentan beneficios en esa terapéutica. Criterios clínicos, electrocardiográficos y ecocardiográficos están siendo estudiados en el intento de seleccionar a los pacientes que se beneficiarán con la resincronización cardiaca, pero lo ecocardiograma juega un rol importante tanto en la selección como en la evaluación y la optimización de esa terapéutica. El objetivo de esta revisión es describir los principales parámetros ecocardiográficos utilizados en la evaluación de la terapia de resincronización cardiaca.Cardiac resynchronization therapy has been an effective option in patients with advanced heart failure. However, 20 to 30% of the patients do not benefit from this therapy. Clinical, electrocardiographic and echocardiographic criteria have been studied in an attempt to select patients who will benefit from a cardiac resynchronization therapy, and the echocardiogram is important both in the selection and in the evaluation and optimization of the therapy. The objective of this review is to describe the main echocardiographic parameters used in the evaluation of the cardiac resynchronization

  7. Alterações da hemostasia em crianças submetidas a cirurgia cardíaca com circulação extracorpórea Hemostatic changes in children undergoing heart surgery with cardiopulmonary bypass

    Fernanda Maria Rebouças da Costa Silveira; Dayse Maria Lourenço; Miguel Maluf; de Carvalho, Werther B; Enio Buffolo; Antonio Carlos Carvalho

    1998-01-01

    OBJETIVO: Avaliar as alterações de hemostasia encontradas em crianças submetidas a cirurgia cardíaca com circulação extracorpórea (CEC). MÉTODOS: Estudamos 17 crianças no pré e pós-operatório (PO) imediato, no 1° PO e entre o 4º e 7º PO, analisando o hematócrito, tempo de protrombina (TP), tempo de tromboplastina parcial ativado, fibrinogênio, contagem de plaquetas, fator V e tempo de lise de euglobulina (TLE). Os pacientes foram divididos em grupos com e sem sangramento excessivo no PO. RESU...

  8. Disección espontánea de arteria ilíaca asociada a ejercicio y uso de ergotamina Spontaneous dissection of iliac artery related with excercise and ergotamine. A case report

    Juan Pablo Fuenzalida G; Angel Puentes R; Sebastián Terrazas F; Sandra Osorio V; Jorge Vergara C.; Eitan Schwartz Y; Rubén Soumastre Ch

    2012-01-01

    Introducción: La disección espontánea de la arteria ilíaca es un cuadro muy poco frecuente asociado a diferentes etiologías que habitualmente se presenta como isquemia de la extremidad comprometida. Caso clínico: Se reporta el caso de un paciente masculino de 48 años con antecedente de consumo crónico de ergotamina, quien mientras practicaba deporte presenta cuadro de isquemia aguda de la extremidad inferior izquierda. Angio tomografía computada demostró disección espontánea de la arteria ilí...

  9. Pesquisa de gliadina em medicamentos: informação relevante para a orientação de pacientes com doença celíaca

    SDEPANIAN Vera Lucia

    2001-01-01

    Full Text Available Racional - Alguns medicamentos podem conter gliadina, portanto, sua utilização poderá ser prejudicial aos pacientes com doença celíaca. Objetivo - Detectar a presença de gliadina em medicamentos comumente comercializados no Brasil. Métodos - Foram analisados 78 medicamentos sorteados a partir de uma lista de 180 produtos comumente comercializados. Os medicamentos analisados foram: analgésicos (n = 9, anti-helmínticos (n = 3, antiácidos (n = 8, antibióticos (n = 13, anticolesterolêmicos (n = 1, anticonvulsivantes (n = 2, antidepressivos (n = 2, antidiabéticos (n = 1, antieméticos (n = 3, anti-hipertensivos (n = 3, anti-histamínicos (n = 3, antiinflamatórios (n = 7, antitérmicos (n = 2, broncodilatadores (n = 1, descongestionantes (n = 4, laxantes (n = 1, contraceptivos orais (n = 5 e vitaminas (n = 10. As amostras foram analisadas pela técnica de ELISA utilizando anticorpo monoclonal ômega-gliadina, considerada de eleição segundo o Codex Alimentarius Commission WHO/FAO. Todas as amostras foram analisadas em duplicata. O nível de detecção do teste é de 4 mg de gliadina/100 g de produto. Resultados - Dentre os 78 medicamentos analisados, em apenas 1 (1,3% foi detectada a presença de gliadina (5,5 mg/100 g. O componente ativo do medicamento é ranitidina. De acordo com o Codex Alimentarius Commission WHO/FAO, o limite máximo diário permitido ao consumo pelos indivíduos com doença celíaca é igual a 10 mg de gliadina. Considerando a quantidade de gliadina num único comprimido de ranitidina, a quantidade ingerida seria bem menor do que a máxima permitida ao consumo pelo paciente com doença celíaca. Conclusões - Neste estudo não foi identificada gliadina em medicamentos em quantidade que constitua risco para pacientes com doença celíaca.

  10. Resposta da frequência cardíaca e da concentração de lactato após cada segmento do triathlon olímpico

    Renata Fiedler Lopes; Raul Osiecki; Luis Manuel Pinto Lopes Rama

    2012-01-01

    INTRODUÇÃO: As respostas fisiológicas de cada uma das modalidades envolvidas no triathlon são diferentes. Cargas de treino poderiam ser melhores prescritas se consideradas as individualidades fisiológicas de cada segmento para cada atleta. OBJETIVO: Observar o comportamento das variáveis fisiológicas, frequência cardíaca (FC) e concentração de lactato sanguíneo, antes e depois de cada segmento do triathlon: natação, ciclismo e corrida. MÉTODOS: Doze atletas do sexo masculino cumpriram uma pro...

  11. Diagnóstico diferencial de trombose aortoilíaca e mieloencefalite protozoária equina: relato de caso Differential diagnosis between aorto-iliac thrombosis and equine protozoal myeloencephalitis: case report

    P.B. Escodro; P.F.R. Lopes; C.G. Gianini; D.N. Jorge Filho

    2010-01-01

    Relata-se o caso de uma égua de atividade de polo, que apresentou inicialmente claudicação leve no membro posterior esquerdo, a qual evoluiu para ataxia e atrofia da musculatura glútea do lado esquerdo, com diagnóstico de trombose aortoilíaca (TAI). A paciente foi tratada com suspeita de mieloencefalite protozoária equina, devido à semelhança dos sinais clínicos com essa doença, porém o líquido cefalorraquidiano apresentou-se negativo para anticorpos anti-Sarcocystis neurona. A palpação trans...

  12. Gasometria arterial em dois diferentes métodos de transporte intra-hospitalar no pós-operatório imediato de cirurgia cardíaca

    Newton Almeida Lima Junior; Silvia Correa Bacelar; André Miguel Japiassú; Samária Ali Cader; Rosane Coelho Fernandes Lima; Estélio Henrique Martin Dantas; Alexandre Gomes Sancho; Jefferson Braga Caldeira

    2012-01-01

    OBJETIVO: Avaliar as repercussões gasométricas de dois métodos de ventilação (ventilador de transporte e ressuscitador manual autoinflável) durante o transporte intra-hospitalar de pacientes submetidos à cirurgia cardíaca. MÉTODOS: Estudo observacional, longitudinal, prospectivo e randomizado. Foram coletadas gasometrias arteriais ao final da cirurgia e ao final do transporte do paciente. RESULTADOS: Foram incluídos 23 pacientes: 13 no Grupo ventilador de transporte e 10 no ressuscitador manu...

  13. Respostas cardiopulmonares ao exercício em pacientes com insuficiência cardíaca congestiva de diferentes faixas etárias Cardiopulmonary responses to exercise in patients of different age group with congestive heart failure

    Marcelo de Castro César; Fábio Tadeu Montesano; Rosiane Vieira Zuza Diniz; Dirceu Rodrigues Almeida; Antonio Sérgio Tebexreni; Turíbio Leite de Barros

    2006-01-01

    OBJETIVOS: Comparar a capacidade funcional cardiorrespiratória no exercício, representada pelos índices de limitação funcional, consumo máximo de oxigênio (VO2máx) e limiar anaeróbico, em pacientes com insuficiência cardíaca congestiva (ICC) de diferentes faixas etárias, e comparar as respostas cardiopulmonares ao exercício máximo. MÉTODOS: Foram avaliados 54 pacientes com ICC, agrupados por faixa etária, como segue: grupo I - idade entre trinta e 39 anos (n = 12); grupo II - idade entre quar...

  14. Celiac disease onset after pegylated interferon and ribavirin treatment of chronic hepatitis C Doença celíaca após tratamento de hepatite C crônica com interferon peguilado e ribavirina

    Elson V. Martins Jr.

    2004-06-01

    Full Text Available AIM: Report of a case of a woman patient who developed celiac disease after pegylated interferon alpha-2a and ribavirin use for chronic hepatitis C. PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment. RESULT: Additional investigation revealed duodenal villous atrophy and positivity for anti-endomysium and anti-gliadin antibodies. Celiac disease diagnosis was performed and symptoms and laboratory abnormalities improved after gluten-free diet. CONCLUSION: Celiac disease must be ruled out in patients with malabsorption complaints in or after interferon (or pegylated interferon therapy. Screening for celiac disease with detection of anti-endomysium antibodies would be done in susceptible patients.OBJETIVO: Relatar caso de doença celíaca ocorrendo após uso de interferon peguilado e ribavirina em paciente com hepatite C crônica. PACIENTE E MÉTODO: Mulher de 34 anos com hepatite C crônica, genótipo 3, tratada com interferon peguilado alfa-2a e ribavirina durante 6 meses, desenvolveu quadro de astenia e anemia após 6 meses do término do tratamento. RESULTADO: Investigação complementar revelou atrofia vilositária à biopsia duodenal e detecção de anticorpos anti-endomísio e anti-gliadina, realizando-se diagnóstico de doença celíaca. Dieta isenta de glúten foi instituída, observando-se boa resposta clínica e laboratorial. CONCLUSÃO: Doença celíaca deve ser afastada em pacientes com quadro de má absorção durante ou após uso de interferon (ou interferon peguilado. Rastreamento de doença celíaca através da realização de anticorpo anti-endomísio pode ser considerado em populações susceptíveis.

  15. Análisis del ECG en monitorización ambulatoria para el diagnóstico cardíaco y la predicción de muerte cardíaca súbita

    Vázquez Seisdedos, Carlos Román

    2001-01-01

    La muerte cardíaca súbita (SCD) es uno de los desafíos más importantes de la cardiología moderna debido al elevado número de personas que fallecen repentinamente sin presentar síntomas previos. Una de las principales causas de la SCD es el infarto de miocardio(IM) pues se estima que el 75 % de las personas que fallecen súbitamente tienen un IM antiguo. El análisis del ECG superficial puede ayudar a prevenir la SCD porque la isquemia miocárdica, que suele preceder al IM, conlleva cambios en la...

  16. Parada cardíaca súbita em anestesia geral como a primeira manifestação da origem anômala de artéria coronária esquerda

    Maurício Daher

    2012-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O relato de caso descreve uma situação rara e potencialmente fatal associada à administração de anestesia. Nosso objetivo foi discutir as causas de parada cardíaca súbita no período perioperatório em pacientes aparentemente saudáveis e a fisiopatologia das anomalias de origem das artérias coronárias como uma causa de parada cardíaca súbita. RELATO DE CASO: Uma mulher de 44 anos, sem sintomas prévios de doença coronariana ou arritmias, apresenta parada cardíaca súbita durante a instalação de anestesia geral em duas situações distintas. No primeiro episódio, a paciente apresentava-se com quadro de abdômen agudo, porém hemodinamicamente estável. Após a indução anestésica, ocorreu bradicardia e hipotensão arterial, refratárias à reposição de volume e vasopressores. O quadro evoluiu para assistolia. A paciente foi reanimada com sucesso e recebeu alta em boas condições. No segundo episódio, um ano após o primeiro, a paciente se encontrava em boas condições clínicas para feitura de uma cirurgia eletiva. Após a indução anestésica, a paciente desenvolveu taquicardia ventricular seguida por assistolia, que foi prontamente revertida. Após extensa investigação, foi identificada uma origem anômala da artéria coronária esquerda. CONCLUSÕES: Nosso relato é ilustrativo ao enfatizar que uma investigação diagnóstica minuciosa deve ser feita nos casos de parada cardíaca súbita perioperatória, mesmo em pacientes aparentemente saudáveis.

  17. ANÁLISE DAS INTERNAÇÕES E DA MORTALIDADE POR DOENÇAS CARDÍACAS ISQUÊMICAS EM IDOSOS NO DISTRITO FEDERAL, NO PERÍODO 2000 A 2012.

    Marcelo Xavier Coelho; Silva, Amanda Alves da; lUCY GOMES Vianna; Clayton Franco Moraes; Gislane Ferreira de Melo

    2015-01-01

    As doenças do aparelho circulatório estão entre as que apresentam maior morbimortalidade. Dentre elas, a cardiopatia isquêmica é a mais prevalente entre os indivíduos idosos (≥60 anos). O objetivo deste estudo foi investigar a incidência de doença cardíaca isquêmica no Brasil e no Distrito Federal (DF). Os dados foram obtidos na base de dados do Sistema de Informações de Mortalidade e no Sistema de Informações Hospitalares do Sistema Único de Saúde, disponibilizado pelo Departamento de Inform...

  18. Diseño de un leudante químico bajo en sodio para preparaciones para la comunidad celíaca Designing a low-sodium chemical leavening for preparations for the celiac community

    Paula Rossi; Rosa Abalos; Sabrina Lencina; Ramiro Tesouro; María Clara Melchiori; Matías Vergara

    2012-01-01

    Se define Enfermedad Celíaca como una intolerancia permanente a determinadas proteínas que se encuentran en el trigo, la cebada, el centeno y la avena. Las harinas no permitidas para los celíacos son más difíciles de manejar, porque no forman la red proteica de gluten que le confiere a los amasados la característica elasticidad y esponjosidad. En la mayoría de los casos se recurre a ingredientes altos en grasa y sodio. Esta situación resulta de gran importancia para la salud ya que el consumo...

  19. Administração de clonidina intravenosa e sua capacidade de reduzir a pressão da artéria pulmonar em pacientes submetidos a cirurgia cardíaca

    Benedito Barbosa João

    2014-01-01

    Full Text Available Objetivo: Avaliar a capacidade da clonidina de reduzir a pressão arterial pulmonar de pacientes com hipertensão pulmonar, submetidos a cirurgia cardíaca, seja pela diminuição dos valores pressóricos a partir da aferição direta da pressão de artéria pulmonar, seja pela redução ouabolição da necessidade de dobutamina e nitroprussiato de sódio no intraoperatório. Método: Trata-se de estudo controlado, comparativo, randomizado e duplamente encoberto feito com 30 pacientes portadores de hipertensão arterial pulmonar tipo 2, submetidos a cirurgia cardíaca. Avaliaram-se a pressão média de artéria pulmonar e a posologia de dobutaminae nitroprussiato de sódio em quatro momentos: (M0 antes da administração de 2 µg/kg declonidina intravenosa ou placebo; (M1 decorridos 30 minutos do tratamento testado e antes da circulação extracorpórea; (M2 imediatamente após a circulação extracorpórea; e (M310 minutos após a injeção de protamina. Resultados: Não houve diferenças significativas em relação à pressão média de artéria pulmonarem nenhum dos momentos estudados. Entre os grupos não houve também diferença significativa entre as demais variáveis estudadas, como pressão arterial sistêmica média, frequência cardíaca, dosagem total de dobutamina, dosagem total de nitroprussiato de sódio e necessidade do hipnoanalgésico fentanil. Conclusão: A análise dos dados obtidos dos pacientes incluídos neste estudo permite concluir que a clonidina, na dose de 2 µg/kg administrada via intravenosa, não foi capaz de reduzir a pressão média de artéria pulmonar de pacientes com hipertensão pulmonar do grupo 2 (hipertensão venosa pulmonar, submetidos a cirurgia cardíaca, e nem reduzir ou abolir a necessidade da administração de dobutamina e nitroprussiato de sódio no intraoperatório.

  20. SEAWEED SUPPLEMENTATION TO PREVENT IODINE DEFICIENCY

    Juhi Agarwal

    2012-12-01

    Full Text Available Iodine is considered as one of the essential elements for the proper functioning of the hormones of human and animal thyroid glands. In many parts of the world iodine deficiency disorders develop because of deficiency of iodine in water and food supply. An iodine deficient goitrous mother may give birth to a cretinous baby because the fetus requires an adequate secretion of thyroxine during the later stages of pregnancy. Seaweed has such a large proportion of iodine compared to dietary minimum requirements, that it is primarily known as a source of this nutrient. A trial study on supplementation of iodine rich seaweed Caulerpa racemosa availed from Gujarat coast was conducted on iodine-deficient or thyroid-insufficient (n=10 pregnant women. They were supplemented daily with 0.17 g of algae in 20 g wheat flour ladoo for one month so as to provide 50μg/day of iodine and 0.343 mg/day of iron. A slight non-significant increase (104.75 to 121.05 μg/L in median urinary iodine concentration (UIC was observed after one month of supplementation. No significant effect of supplementation was observed on thyroid function parameters of the subjects. They also showed slight increase in hemoglobin level. Prolonged supplementation needs to be carried out further to opine on the impact of algae.