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Sample records for aca supplementation strain

  1. Performance of the auxotrophic Saccharomyces cerevisiae BY4741 as host for the production of IL-1β in aerated fed-batch reactor: role of ACA supplementation, strain viability, and maintenance energy

    Zueco Jesus

    2009-12-01

    Full Text Available Abstract Background Saccharomyces cerevisiae BY4741 is an auxotrophic commonly used strain. In this work it has been used as host for the expression and secretion of human interleukin-1β (IL1β, using the cell wall protein Pir4 as fusion partner. To achieve high cell density and, consequently, high product yield, BY4741 [PIR4-IL1β] was cultured in an aerated fed-batch reactor, using a defined mineral medium supplemented with casamino acids as ACA (auxotrophy-complementing amino acid source. Also the S. cerevisiae mutant BY4741 Δyca1 [PIR4-IL1β], carrying the deletion of the YCA1 gene coding for a caspase-like protein involved in the apoptotic response, was cultured in aerated fed-batch reactor and compared to the parental strain, to test the effect of this mutation on strain robustness. Viability of the producer strains was examined during the runs and a mathematical model, which took into consideration the viable biomass present in the reactor and the glucose consumption for both growth and maintenance, was developed to describe and explain the time-course evolution of the process for both, the BY4741 parental and the BY4741 Δyca1 mutant strain. Results Our results show that the concentrations of ACA in the feeding solution, corresponding to those routinely used in the literature, are limiting for the growth of S. cerevisiae BY4741 [PIR4-IL1β] in fed-batch reactor. Even in the presence of a proper ACA supplementation, S. cerevisiae BY4741 [PIR4-IL1β] did not achieve a high cell density. The Δyca1 deletion did not have a beneficial effect on the overall performance of the strain, but it had a clear effect on its viability, which was not impaired during fed-batch operations, as shown by the kd value (0.0045 h-1, negligible if compared to that of the parental strain (0.028 h-1. However, independently of their robustness, both the parental and the Δyca1 mutant ceased to grow early during fed-batch runs, both strains using most of the

  2. Affordable Care Act (ACA)

    Social Security Administration — The Affordable Care Act (ACA) is a federal statute enacted with a goal of increasing the quality and affordability of health insurance. Through a web service, CMS...

  3. Tryptophan provision by dietary supplementation of a Bacillus subtilis mutant strain in piglets

    Torres-Pitarch, A; Nielsen, B.; Canibe, Nuria;

    2015-01-01

    Supplementing Bacillus (B.) subtilis mutants selected to overproduce a specific amino acid (AA) may be an alternative method to provide essential AA in pig diets. Two experiments on a B. subtilis strain selected to overproduce Trp were conducted using 8-kg pigs fed Trp-deficient diets for 20 d. B....... subtilis were supplied in a low or high dose in Experiments 1 and 2, respectively. The Trp-deficient diet (0.15 SID Trp:Lys) reduced (p < .05) both gain and feed intake of piglets compared to the positive control diet (0.17 SID Trp:Lys). Supplementation of the B. subtilis strain was not able to...... counterbalance the Trp deficiency in any of the two experiments. No effect of B. subtilis supplementation to piglet diets was observed on the plasma AA profile. In conclusion, this mutant strain of B. subtilis was not able to compensate a Trp deficiency in the tested doses....

  4. The effect of multivitamin-multimineral supplementation on the health status of inbred Wistar and spontaneously hypertensive rat strains

    Rosemarie U. Höfler; Mahendra L. Channa; Anand Nadar

    2016-01-01

    The nutraceutical industry has proliferated in recent years, with the most popular form of supplementation being the multivitamin-multimineral (MVMM) supplement. In the animal health sector, supplement use has also expanded. The objective of this study was to determine the effects of MVMM supplementation, beneficial or otherwise, on the general health status of the spontaneously hypertensive rat (SHR) strain, an animal model used in hypertension research. A commercially prepared MVMM suppleme...

  5. Influência da suplementação de creatina na capacidade funcional de pacientes com Insuficiência Cardíaca Influence of creatine supplementation on the functional capacity of patients with Heart Failure

    Ana Paula Perillo Ferreira Carvalho

    2012-07-01

    Full Text Available FUNDAMENTO: A Insuficiência Cardíaca (IC é uma síndrome complexa, marcada pela intolerância ao esforço e perda da capacidade funcional. OBJETIVO: Avaliar a capacidade funcional dos pacientes com IC suplementados com creatina. MÉTODOS: Estudo prospectivo, randomizado, duplo cego. Foram randomizados em dois grupos 33 pacientes com IC, com idade > 18 anos, sexo masculino, classes funcionais II a IV. O grupo experimental (G CRE, n = 17 foi suplementado com creatina com dose de 5 g por dia durante seis meses. E o grupo placebo (G PLA, n = 16 recebeu 5 g de maltodextrina por dia durante o mesmo período de tempo. Ambos os grupos foram submetidos a avaliação da capacidade funcional por meio da ergoespirometria e teste de caminhada de seis minutos (TC6 pré e pós-intervenção. O modelo estatístico Ancova e a correlação de Pearson foram utilizados na análise dos grupos e nas formas de tratamento. RESULTADOS: Das variáveis avaliadas na ergoespirometria, o volume de oxigênio pico (VO2 pico, limiar anaeróbio (LA e o pulso de oxigênio (pulso de O2 não apresentaram diferenças significativas entre os grupos (P>0,05. No TC6 não houve diferença significativa na distância percorrida. CONCLUSÃO: A suplementação de creatina em pacientes com IC não promoveu melhora significativa na capacidade funcional.BACKGROUND: Heart failure (HF is a complex syndrome characterized by intolerance to exertion and reduced functional capacity. OBJECTIVE: To assess the functional capacity of patients with HF and supplemented with creatine. METHODS: Prospective, randomized, double-blind study. Thirty-three male patients over the age of 18 years with functional class II to IV HF were randomized into two groups as follows: the experimental group (CRE, n = 17, supplemented with 5 g/day of creatine for six months; and the placebo group (PLA, n = 16, receiving 5 g/day of maltodextrin for that same period. Both groups underwent functional capacity assessment by

  6. EFFECT OF DIETARY SUPPLEMENTATION OF MULTI-STRAIN PROBIOTIC ON BROILER GROWTH PERFORMANCE

    M. I. Anjum, A. G. Khan, A. Azim and M. Afzal1

    2005-01-01

    Full Text Available The effects of a multi-strain probiotic (protexin on broiler growth performance, carcass parameters and economic efficiency were studied. For this purpose, 270 day-old broiler chicks were randomly divided into three experimental groups A, B and C, with 90 chicks in each group having three replicates. Group A was fed commercial broiler diet without supplementation of protexin (control and groups B and C were fed diets containing protexin 100 and 110g/t in starter and 50 and 55 g/t in finisher diets, respectively. Feed and water were offered ad libitum. The results showed that weight gain and feed conversion ratio were significantly (p<0.05 improved in chicks fed on protexin-supplemented diets compared to control diets. Weight gain of the chicks fed on diet C was significantly (p<0.05 better than chicks on diet B. Feed conversion ratio was non-significantly different in both the protexin-supplemented groups. Differences in feed intake, meat composition, dressing percentage and empty organ weights among all the diets were non-significant. However, abdominal fat content was reduced significantly (P<0.05 in supplemented groups. The study suggests that protexin supplementation is beneficial for better weight gains, feed efficiency and economic efficiency in broiler chicks.

  7. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants.

    Berni Canani, Roberto; Sangwan, Naseer; Stefka, Andrew T; Nocerino, Rita; Paparo, Lorella; Aitoro, Rosita; Calignano, Antonio; Khan, Aly A; Gilbert, Jack A; Nagler, Cathryn R

    2016-03-01

    Dietary intervention with extensively hydrolyzed casein formula supplemented with Lactobacillus rhamnosus GG (EHCF+LGG) accelerates tolerance acquisition in infants with cow's milk allergy (CMA). We examined whether this effect is attributable, at least in part, to an influence on the gut microbiota. Fecal samples from healthy controls (n=20) and from CMA infants (n=19) before and after treatment with EHCF with (n=12) and without (n=7) supplementation with LGG were compared by 16S rRNA-based operational taxonomic unit clustering and oligotyping. Differential feature selection and generalized linear model fitting revealed that the CMA infants have a diverse gut microbial community structure dominated by Lachnospiraceae (20.5±9.7%) and Ruminococcaceae (16.2±9.1%). Blautia, Roseburia and Coprococcus were significantly enriched following treatment with EHCF and LGG, but only one genus, Oscillospira, was significantly different between infants that became tolerant and those that remained allergic. However, most tolerant infants showed a significant increase in fecal butyrate levels, and those taxa that were significantly enriched in these samples, Blautia and Roseburia, exhibited specific strain-level demarcations between tolerant and allergic infants. Our data suggest that EHCF+LGG promotes tolerance in infants with CMA, in part, by influencing the strain-level bacterial community structure of the infant gut. PMID:26394008

  8. The effect of multivitamin-multimineral supplementation on the health status of inbred Wistar and spontaneously hypertensive rat strains.

    Höfler, Rosemarie U; Channa, Mahendra L; Nadar, Anand

    2016-01-01

    The nutraceutical industry has proliferated in recent years, with the most popular form of supplementation being the multivitamin-multimineral (MVMM) supplement. In the animal health sector, supplement use has also expanded. The objective of this study was to determine the effects of MVMM supplementation, beneficial or otherwise, on the general health status of the spontaneously hypertensive rat (SHR) strain, an animal model used in hypertension research. A commercially prepared MVMM supplement was given tri-weekly via oral dosing for 8 weeks to two groups of seven adult female SHR and Wistar rats. Their corresponding control groups were dosed with deionised water only. Systolic and diastolic blood pressure, fasting blood glucose, growth rate and food and water intake were measured weekly. At the end of 8 weeks, the animals were euthanased and a full blood profile, urine sodium to potassium ratio, blood urea nitrogen levels and total plasma cholesterol was measured for all groups. The results indicated that growth rate was higher for the SHR supplemented group. Supplementation also decreased diastolic blood pressure in both Wistar and SHR groups and increased red blood cell count and decreased total cholesterol in the SHR group. No adverse effects on the general health status of the animals were observed. MVMM supplementation may therefore be useful in aiding growth and delaying the onset of hypertension and its effects. It may also assist in the longevity of the breeding stock of SHR rats. PMID:27381881

  9. Development of minimal fermentation media supplementation for ethanol production using two Saccharomyces cerevisiae strains.

    Tropea, Alessia; Wilson, David; Cicero, Nicola; Potortì, Angela G; La Torre, Giovanna L; Dugo, Giacomo; Richardson, David; Waldron, Keith W

    2016-05-01

    Ethanol production by fermentation is strongly dependent on media composition. Specific nutrients, such as trace elements, vitamins and nitrogen will affect the physiological state and, consequently, the fermentation performance of the micro-organism employed. The purpose of this study has been to assess the highest ethanol production by a minimal medium, instead of the more complex nutrients supplementation used during alcoholic fermentation. All fermentation tests were carried out using a microwell plate reader to monitor the processes. Two Saccharomyces cerevisiae strains (NCYC 2826 and NCYC 3445) were tested using three nitrogen sources, supplied with different vitamin and salts. The results show that solutions made of urea phosphate, KCl, MgSO4·7H2O, Ca-panthothenate, biotin allowed an ethanol yield of 22.9 and 23.4 g/L for strain NCYC 2826 and NCYC 3445, respectively, representing 90 and 92% of the theoretical yield. All tests were carried out using glucose as common reference carbon source. PMID:26469871

  10. The effect of multivitamin-multimineral supplementation on the health status of inbred Wistar and spontaneously hypertensive rat strains

    Rosemarie U. Höfler

    2016-02-01

    Full Text Available The nutraceutical industry has proliferated in recent years, with the most popular form of supplementation being the multivitamin-multimineral (MVMM supplement. In the animal health sector, supplement use has also expanded. The objective of this study was to determine the effects of MVMM supplementation, beneficial or otherwise, on the general health status of the spontaneously hypertensive rat (SHR strain, an animal model used in hypertension research. A commercially prepared MVMM supplement was given tri-weekly via oral dosing for 8 weeks to two groups of seven adult female SHR and Wistar rats. Their corresponding control groups were dosed with deionised water only. Systolic and diastolic blood pressure, fasting blood glucose, growth rate and food and water intake were measured weekly. At the end of 8 weeks, the animals were euthanased and a full blood profile, urine sodium to potassium ratio, blood urea nitrogen levels and total plasma cholesterol was measured for all groups. The results indicated that growth rate was higher for the SHR supplemented group. Supplementation also decreased diastolic blood pressure in both Wistar and SHR groups and increased red blood cell count and decreased total cholesterol in the SHR group. No adverse effects on the general health status of the animals were observed. MVMM supplementation may therefore be useful in aiding growth and delaying the onset of hypertension and its effects. It may also assist in the longevity of the breeding stock of SHR rats.Keywords: multivitamin-multimineral (MVMM supplementation; hypertension; spontaneously hypertensive rats (BRU; Wistar rats; breeding stock

  11. Malondialdeído e troponina I cardíaca em equinos da raça Puro Sangue Árabe submetidos ao exercício e à suplementação com vitamina E Malondialdehyde and cardiac troponin I in Arabian horses subjected to exercise and vitamin E supplementation

    Letícia Andreza Yonezawa

    2010-06-01

    Full Text Available Para avaliar o efeito do exercício físico, do treinamento e da suplementação com vitamina E sobre o malondialdeído (MDA e a troponina I cardíaca (cTnI séricos, foram utilizados 16 equinos da raça Puro Sangue Árabe, sem treinamento, divididos em dois grupos de oito: controle e suplementado com vitamina E. Ambos os grupos foram submetidos a provas de exercício progressivo em esteira de alta velocidade inclinada a +7%, antes (P1 e após (P2 o período de treinamento de 20 dias. Foram determinadas as concentrações séricas de MDA, vitamina E e cTnI e realizou-se o eletrocardiograma de repouso antes e após as provas P1 e P2. Os resultados sugerem a ocorrência do estresse oxidativo ocasionado pelo exercício, determinado por meio do aumento de MDA sérico. Em alguns animais, houve um discreto aumento de cTnI associado à detecção de complexos ventriculares prematuros, mas que não representou lesão cardíaca expressiva. Não houve efeito do treinamento sobre o estresse oxidativo. Portanto, é possível concluir que o exercício físico progressivo promoveu a lipoperoxidação nessas condições, que não foi prevenida pela suplementação com vitamina E nem pelo treinamento, mas não foi suficiente para causar uma lesão cardíaca significativa.To evaluate the effect of exercise, training and vitamin E supplementation on serum malondialdehyde (MDA and cardiac troponin I (cTnI, sixteen adult untrained Arabian horses were divided into 2 groups of 8 animals each, control and supplemented with vitamin E. Both groups had incremental exercise tests performed on a high-speed treadmill at a +7% slope, before (P1 and after (P2 a training period of 20 days. Serum concentrations of MDA, vitamin E and cTnI, and resting electrocardiogram were performed before and after P1 and P2. Results suggested that oxidative stress was induced by exercise as measured by serum MDA increase. In some animals, there was a subtle increase in cTnI concentration

  12. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants

    Berni Canani, Roberto; Sangwan, Naseer; Stefka, Andrew T.; Nocerino, Rita; Paparo, Lorella; Aitoro, Rosita; Calignano, Antonio; Khan, Aly A.; Gilbert, Jack A.; Nagler, Cathryn R.

    2015-01-01

    Dietary intervention with extensively hydrolyzed casein formula supplemented with Lactobacillus rhamnosus GG (EHCF+LGG) accelerates tolerance acquisition in infants with cow's milk allergy (CMA). We examined whether this effect is attributable, at least in part, to an influence on the gut microbiota. Fecal samples from healthy controls (n=20) and from CMA infants (n=19) before and after treatment with EHCF with (n=12) and without (n=7) supplementation with LGG were compared by 16S rRNA-based ...

  13. Insuficiencia cardíaca y diabetes

    Jorge Thierer

    2006-01-01

    La prevalencia de la insuficiencia cardíaca y la diabetes continúa creciendo. Ambas están fuertemente asociadas. La diabetes es un fuerte predictor de aparición de insuficiencia cardíaca. Las razones son la presencia de enfermedad coronaria y los trastornos metabólicos vinculados con la resistencia a la insulina que generan disfunción contráctil. Los pacientes con insuficiencia cardíaca que son diabéticos tienen peor evolución. Los Betabloqueantes, vasodilatadores y los inhibidores de la en...

  14. Effects of nutritional supplementation with l-arginine on repair of injuries due to muscle strain: experimental study on rats

    Lauren Izabel Medeiros Couto

    2015-08-01

    Full Text Available ABSTRACTOBJECTIVE: To evaluate the influence of oral supplementation with arginine on regeneration of injuries due to straining of the anterior tibial muscle of rats. METHODS: Twenty-four Wistar rats of weight 492.5 ± 50.45 g were used. Injuries were induced through straining the anterior tibial muscles. The rats were separated into three groups of eight rats each. In the untreated group (UTG, after induction of injuries, the rats were observed for 24 h. In the simulation group (SG and the arginine group (AG respectively, the rats received isotonic saline solution and arginine solution via direct gavage, over a seven-day period. At the end of the period, blood samples were collected for serum evaluations of creatine kinase (CK, lactic dehydrogenase (LDH, aspartate aminotransferase (AST and C-reactive protein (CRP. The right and left anterior tibial muscles were resected for histopathological evaluations on the muscle injuries, investigating edema, hemorrhage and disorganization or morphometric alteration of the muscle fibers. The tissue repair was investigated in terms of proliferation of adipose tissue, angiogenesis and collagen fibers. The ANOVA and Student's tmethods were used and p≤ 0.05 was taken to be statistically significant. RESULTS: In the serum evaluations, the AG showed lower CK assay values and higher AST values. In the histopathological evaluation, the UTG presented edema and hemorrhage compatible with injuries due to strain; the SG presented edema and hemorrhage with proliferation of adipose tissue and collagen fibers; and the AG presented not only the findings of the SG but also, especially, intense angiogenesis. CONCLUSION: Oral supplementation with arginine did not cause any significant metabolic alterations that would contraindicate its use and it induced angiogenesis during the repair of muscles injured due to strain.

  15. Levan-Producing Leuconostoc citreum Strain BD1707 and Its Growth in Tomato Juice Supplemented with Sucrose.

    Han, Jin; Xu, Xiaofen; Gao, Caixia; Liu, Zhenmin; Wu, Zhengjun

    2016-03-01

    A levan-producing strain, BD1707, was isolated from Tibetan kefir and identified as Leuconostoc citreum. The effects of carbon sources on the growth of L. citreum BD1707 and levan production in tomato juice were measured. The changes in pH, viable cell count, sugar content, and levan yield in the cultured tomato juice supplemented with 15% (wt/vol) sucrose were also assayed. L. citreum BD1707 could synthesize more than 28 g/liter of levan in the tomato juice-sucrose medium when cultured at 30°C for 96 h. Based on the monosaccharide composition, molecular mass distribution, Fourier transform infrared (FTIR) spectra, and nuclear magnetic resonance (NMR) spectra, the levan synthesized by L. citreum BD1707 was composed of a linear backbone consisting of consecutive β-(2→6) linked d-fructofuranosyl units, with an estimated average molecular mass of 4.3 × 10(6) Da. PMID:26682858

  16. 77 FR 65006 - Air Cargo Advance Screening (ACAS) Pilot Program

    2012-10-24

    ... December 5, 2003, CBP published a final rule in the Federal Register (68 FR 68140) to effectuate the... secure VPN connection with CBP that the ACAS pilot participant is willing to set up. ACAS...

  17. Dietary supplementation of a mixture of Lactobacillus strains enhances performance of broiler chickens raised under heat stress conditions

    Faseleh Jahromi, Mohammad; Wesam Altaher, Yassir; Shokryazdan, Parisa; Ebrahimi, Roohollah; Ebrahimi, Mahdi; Idrus, Zulkifli; Tufarelli, Vincenzo; Liang, Juan Boo

    2016-07-01

    High ambient temperature is a major problem in commercial broiler production in the humid tropics because high producing broiler birds consume more feed, have higher metabolic activity, and thus higher body heat production. To evaluate the effects of two previously isolated potential probiotic strains ( Lactobacillus pentosus ITA23 and Lactobacillus acidophilus ITA44) on broilers growing under heat stress condition, a total of 192 chicks were randomly allocated into four treatment groups of 48 chickens each as follows: CL, birds fed with basal diet raised in 24 °C; PL, birds fed with basal diet plus 0.1 % probiotic mixture raised in 24 °C; CH, birds fed with basal diet raised in 35 °C; and PH, birds fed with basal diet plus 0.1 % probiotic mixture raised in 35 °C. The effects of probiotic mixture on the performance, expression of nutrient absorption genes of the small intestine, volatile fatty acids (VFA) and microbial population of cecal contents, antioxidant capacity of liver, and fatty acid composition of breast muscle were investigated. Results showed that probiotic positively affected the final body weight under both temperature conditions (PL and PH groups) compared to their respective control groups (CL and CH). Probiotic supplementation numerically improved the average daily gain (ADG) under lower temperature, but significantly improved ADG under the higher temperature ( P < 0.05) by sustaining high feed intake. Under the lower temperature environment, supplementation of the two Lactobacillus strains significantly increased the expression of the four sugar transporter genes tested (GLUT2, GLUT5, SGLT1, and SGLT4) indicating probiotic enhances the absorption of this nutrient. Similar but less pronounced effect was also observed under higher temperature (35 °C) condition. In addition, the probiotic mixture improved bacterial population of the cecal contents, by increasing beneficial bacteria and decreasing Escherichia coli population, which could be

  18. Dietary supplementation of a mixture of Lactobacillus strains enhances performance of broiler chickens raised under heat stress conditions

    Faseleh Jahromi, Mohammad; Wesam Altaher, Yassir; Shokryazdan, Parisa; Ebrahimi, Roohollah; Ebrahimi, Mahdi; Idrus, Zulkifli; Tufarelli, Vincenzo; Liang, Juan Boo

    2015-11-01

    High ambient temperature is a major problem in commercial broiler production in the humid tropics because high producing broiler birds consume more feed, have higher metabolic activity, and thus higher body heat production. To evaluate the effects of two previously isolated potential probiotic strains (Lactobacillus pentosus ITA23 and Lactobacillus acidophilus ITA44) on broilers growing under heat stress condition, a total of 192 chicks were randomly allocated into four treatment groups of 48 chickens each as follows: CL, birds fed with basal diet raised in 24 °C; PL, birds fed with basal diet plus 0.1 % probiotic mixture raised in 24 °C; CH, birds fed with basal diet raised in 35 °C; and PH, birds fed with basal diet plus 0.1 % probiotic mixture raised in 35 °C. The effects of probiotic mixture on the performance, expression of nutrient absorption genes of the small intestine, volatile fatty acids (VFA) and microbial population of cecal contents, antioxidant capacity of liver, and fatty acid composition of breast muscle were investigated. Results showed that probiotic positively affected the final body weight under both temperature conditions (PL and PH groups) compared to their respective control groups (CL and CH). Probiotic supplementation numerically improved the average daily gain (ADG) under lower temperature, but significantly improved ADG under the higher temperature (P < 0.05) by sustaining high feed intake. Under the lower temperature environment, supplementation of the two Lactobacillus strains significantly increased the expression of the four sugar transporter genes tested (GLUT2, GLUT5, SGLT1, and SGLT4) indicating probiotic enhances the absorption of this nutrient. Similar but less pronounced effect was also observed under higher temperature (35 °C) condition. In addition, the probiotic mixture improved bacterial population of the cecal contents, by increasing beneficial bacteria and decreasing Escherichia coli population, which could be

  19. The cytotoxic effects a of ACA1 on human melanoma cell line

    R. Yaraie

    2006-01-01

    Full Text Available Background and purpose: Different methods such as surgery, chemotherapy, radiotherapy, hormone therapy and immunotherapy are used for treatment of melanoma cancer. Unfortunately they don't always have desirable results and they may have unfavorable side effects. Researchers try to find new, more effective drugs with low side effects. In this study we evaluated the cytotoxic effect of ACA-1, a water extract of a traditional Iranian medicinal herbs on a melanoma cell line SKMEL-3.Materials and Methods: The SKMEL3 cell line was obtained from Pasture institute, Tehran, Iran and cultured in RPMI media supplemented with 10% FBS. Equal number of cells were added to a 96 well microplate and were incubated with various doses of ACA1 (5,2,1,0.2,0.1,0.05,0.02 and 0.01 mg/ml for 24, 48 and 72 hours in parallel. The cytotoxic effects of the drug was evaluated using MTT assay.Results: The Results showed that ACA1 has significant cytotoxic effects with dose and time dependent manner on SKMEL3. The optimum dose (5 mg/ml showed 47% cytotoxicity in 24 h, 65% cytotoxicity in 48 h and 71% cytotoxicity in 72 h. Conclusion: Based on the results of this research, ACA1 is a suitable candidate for chemotherapy of melanoma patients. Further studies are necessary in order to find effective drugs, their effects on other cell lines and approved in vivo models and clinical trials.

  20. Influence of Supplemental Dietary Poultry Fat on the Yolk Characteristics of Commercial Layers Inoculated Before or at the Onset of Lay with F-Strain Mycoplasma gallisepticum

    The effects of F-strain Mycoplasma gallisepticum (FMG) inoculation and 1.5 % supplemental dietary poultry fat (PF) on the egg yolk characteristics of commercial layers between 24 and 58 wk of age were investigated. Sham and FMG inoculations were administered at 12 (before lay) and 22 (early in lay)...

  1. Insuficiencia cardíaca y diabetes

    Jorge Thierer

    2006-01-01

    Full Text Available La prevalencia de la insuficiencia cardíaca y la diabetes continúa creciendo. Ambas están fuertemente asociadas. La diabetes es un fuerte predictor de aparición de insuficiencia cardíaca. Las razones son la presencia de enfermedad coronaria y los trastornos metabólicos vinculados con la resistencia a la insulina que generan disfunción contráctil. Los pacientes con insuficiencia cardíaca que son diabéticos tienen peor evolución. Los Betabloqueantes, vasodilatadores y los inhibidores de la enzima convertidora ejercen una influencia favorable, en tanto que el uso de glitazonas todavía es controversial. La insuficiencia cardíaca puede a su vez generar diabetes, debido a la activación del sistema nervioso simpático y al efecto del tratamiento. La comprensión adecuada de estos hechos es fundamental para tomar decisiones correctas y mejorar la suerte de los pacientes.

  2. Effect of isolate of ruminal fibrolytic bacterial culture supplementation on fibrolytic bacterial population and survivability of inoculated bacterial strain in lactating Murrah buffaloes

    Brishketu Kumar

    2013-02-01

    Full Text Available Aim: The present study was conducted to evaluate the effect of bacterial culture supplementation on ruminal fibrolytic bacterial population as well as on survivability of inoculated bacterial strain in lactating Murrah buffaloes kept on high fibre diet. Materials and Methods: Fibrolytic bacterial strains were isolated from rumen liquor of fistulated Murrah buffaloes and live bacterial culture were supplemented orally in treatment group of lactating Murrah buffaloes fed on high fibre diet to see it's effect on ruminal fibrolytic bacterial population as well as to see the effect of survivability of the inoculated bacterial strain at three different time interval in comparison to control group. Results: It has been shown by real time quantification study that supplementation of bacterial culture orally increases the population of major fibre degrading bacteria i.e. Ruminococcus flavefaciens, Ruminococcus albus as well as Fibrobacter succinogenes whereas there was decrease in secondary fibre degrading bacterial population i.e. Butyrivibrio fibrisolvens over the different time periods. However, the inoculated strain of Ruminococcus flavefaciens survived significantly over the period of time, which was shown in stability of increased inoculated bacterial population. Conclusion: The isolates of fibrolytic bacterial strains are found to be useful in increasing the number of major ruminal fibre degrading bacteria in lactating buffaloes and may act as probiotic in large ruminants on fibre-based diets. [Vet World 2013; 6(1.000: 14-17

  3. Effect of Probiotic Strain Enterococcus faecium M74 Supplementation on the Carcass Parameters of Different Hybrid Combination Chickens

    Ján Weis

    2011-05-01

    Full Text Available The aim of the present study was to evaluate the effect of addition of Enterococcus faecium M74 in drinking water on performance and carcass characteristics of broiler chickens. Totally 120 chickens (60 of hybrid Hybro, 60 of Ross 308 were divided to two groups. Experimental chickens of Hybro (n=30 and Ross 308 (n=30 received a probiotic preparation in drinking water from day 1 to day 42 with concentration of 2x109 CFU of Enterococcus faecium M 74 in 1 g of nutrient medium with dextrose. The control group of Hybro (n=30 and Ross 308 (n=30 received water in same total amount as experimental group without any additives. The feeding period lasted 42 days. In case of Hybro, we showed higher effect of Enterococcus faecium M74 supplementation on slaughter weight (1807.51 vs. 1929.08 g; P0.05 in comparison with Ross 308 (2126.63 vs. 2199.31g; P>0.05. Differences in percentage of valuable parts (thigh and breast and carcass yield of Hybro and Ross 308 were not statistically significant (P>0.05 by addition of probiotic On the end of fattening, Ross 308 broiler chickens fed diet with probiotic strain Enterococcus faecium had significantly less (P<0.05 abdominal fat than those fed without the probiotic. In Hybro broiler chickens we recorded not significant difference between groups (P>0.05.

  4. Long-term effects of dietary supplementation with an essential oil mixture on the growth and laying performance of two layer strains

    Mehmet Pamukçu; Metin Çabuk; Mehmet Bozkurt; Kamil Küçükyilmaz; Ahmet Alçiçek; Abdullah U. Çatli

    2012-01-01

    One thousand two hundred 1-day-old Lohmann LSL white and Lohmann Brown layer chickens were fed diets supplemented with either an antibiotic growth promoter (AGP) or an herbal essential oil mixture (EOM) till 58 wk of age to reveal the long-term effects of those additives on growth, performance and wholesome egg quality parameters. The study was arranged in a 2x3 factorial design with two layer strains and three feed additive regimens. Thus, the layer birds of both strains were randomly assign...

  5. Caquexia cardíaca Cardiac cachexia

    Alberto Miján

    2006-05-01

    Full Text Available La insuficiencia cardíaca de carácter crónico (ICC, en especial si afecta al corazón derecho, ocasiona con frecuencia malnutrición. Si esta es grave y se unen otros componentes, puede producirse caquexia cardíaca. Esta se asocia a mayor morbilidad y menor supervivencia de los pacientes que la padecen. Las causas de la caquexia cardíaca son diversas, en general asociadas a mantener balance energético negativo, surgiendo cada vez mayor evidencia que apoya un origen multifactorial de la misma. Entre otros, factores neurohormonales, inflamatorios, inmunológicos y metabólicos se superponen en el paciente con ICC, pudiendo producir afectación y deterioro de diversos órganos o sistemas, incluyendo la caquexia cardíaca. Esta puede definirse de diversos modos que, en general, concretan una reducción de peso en un tiempo definido o de estructuras corporales, ya que esta entidad afecta tanto a la masa magra o celular activa, como a los tejidos adiposo y óseo "osteoporosis. De todos ellos, el deterioro más acusado puede observarse en el tejido muscular esquelético, tanto a nivel estructural como funcional, no quedando exento el corazón de su afectación. Respecto del tratamiento, este debe basarse en la evidencia científica disponible. La valoración del estado nutricional de todo paciente con ICC es obligada, debiendo intervenir nutricionalmente ante MEP o riesgo de desarrollarla. En esta situación, mas si existe caquexia cardíaca, es necesaria una modificación de la dieta oral en energía y calidad de la misma, debiendo valorar la indicación de nutrición artificial específica complementaria o alternativa. Asimismo, cada vez adquiere mayor fuerza causal el papel beneficioso del ejercicio físico moderado, así como de la modulación por determinados fármacos de las alteraciones metabólicas e inflamatorias observadas en la caquexia cardíaca, que incluyen una respuesta favorable a nivel funcional y estructural del paciente con ICC

  6. Insuficiencia cardíaca neonatal

    Pastor Durán, Xavier

    1986-01-01

    PROTOCOLOS TERAPEUTICOS. INSUFICIENCIA CARDIACA NEONATAL. 1. CONCEPTO La insuficiencia cardíaca (IC) en el recién nacido suele manifestarse de forma global salvo en contadas ocasiones (ciertas cardiopatías congénitas). Las causas pueden ser múltiples, desde problemas hidroelectrolíticos hasta infecciones, pasando por la yatrogenia de la sobrecarga hídrica debida a una mala prescripción de las perfusiones. Un intento de clasificación puede ser el siguiente...

  7. Promoting Systemic Change through the ACA Advocacy Competencies

    Toporek, Rebecca L.; Lewis, Judith A.; Crethar, Hugh C.

    2009-01-01

    In 2003, the American Counseling Association (ACA) adopted the ACA Advocacy Competencies (J. A. Lewis, M. S. Arnold, R. House, & R. L. Toporek, 2002) to provide guidance to counselors and acknowledge advocacy as an ethical aspect of service to clients. This article provides a foundation for this special section by sharing a historical perspective…

  8. Long-term effects of dietary supplementation with an essential oil mixture on the growth and laying performance of two layer strains

    Mehmet Pamukçu

    2012-01-01

    Full Text Available One thousand two hundred 1-day-old Lohmann LSL white and Lohmann Brown layer chickens were fed diets supplemented with either an antibiotic growth promoter (AGP or an herbal essential oil mixture (EOM till 58 wk of age to reveal the long-term effects of those additives on growth, performance and wholesome egg quality parameters. The study was arranged in a 2x3 factorial design with two layer strains and three feed additive regimens. Thus, the layer birds of both strains were randomly assigned to the three dietary treatments, i.e., standard basal diet (control, control with AGP (specifically, avilamycin, 10 mg/kg diet and control with EOM (24 mg/kg diet. The data regarding egg production were recorded between 22 to 58 weeks of age. Neither the dietary treatments nor the bird strain influenced the body weight and mortality of the birds in both the growing and laying period. AGP or EOM supplementation to the laying hen diet significantly increased the egg production rate and egg weight as compared to the control diet alone, but egg mass output, feed consumption, and feed conversion ratio were not effected by the dietary treatments. Neither dietary treatment created any statistically significantly differences in egg quality parameters with the exception of Haugh unit. The research findings have confirmed the beneficial effects of supplementation with feed-grade EOM on the laying rate and egg weight of both white and brown layers. Indeed, EOM, being a novel feed additive natural origin, proved to be as efficacious as AGP in promoting egg yield.

  9. Long-term effects of dietary supplementation with an essential oil mixture on the growth and laying performance of two layer strains

    Abdullah U. Çatli

    2012-01-01

    Full Text Available One thousand two hundred 1-day-old Lohmann LSL white and Lohmann Brown layer chickens were fed diets supplemented with either an antibiotic growth promoter (AGP or an herbal essential oil mixture (EOM till 58 wk of age to reveal the long-term effects of those additives on growth, performance and wholesome egg quality parameters. The study was arranged in a 2x3 factorial design with two layer strains and three feed additive regimens. Thus, the layer birds of both strains were randomly assigned to the three dietary treatments, i.e., standard basal diet (control, control with AGP (specifically, avilamycin, 10 mg/kg diet and control with EOM (24 mg/kg diet. The data regarding egg production were recorded between 22 to 58 weeks of age. Neither the dietary treatments nor the bird strain influenced the body weight and mortality of the birds in both the growing and laying period. AGP or EOM supplementation to the laying hen diet significantly increased the egg production rate and egg weight as compared to the control  diet alone, but egg mass output, feed consumption, and feed conversion ratio were not effected  by the dietary treatments. Neither dietary treatment created any statistically significantly differences in egg quality parameters with the exception of Haugh unit. The research findings have confirmed the beneficial effects of supplementation with feed-grade EOM on the laying rate and egg weight of both white and brown layers. Indeed, EOM, being a novel feed additive natural origin, proved to be as efficacious as AGP in promoting egg yield.

  10. EHS & LCA assessment for 7-ACA synthesis

    Henderson, Richard K; Jiménez-González, Concepción; Preston, Chris;

    2008-01-01

    study were a chemical synthetic process and a two-enzyme catalyzed process, both starting from the potassium salt of cephalosporin C. Cradle-to-gate life cycle impact estimations were performed using the Fast Life Cycle Assessment of Synthetic Chemistry (FLASC™) tool and following modular gate......-to-gate methodology. The results compare the synthetic efficiency, environment, health, safety, and life cycle metrics for a mature chemical process and a more recent but less developed enzymatic process for making 7-ACA. The chemical process has a higher yield, but a significantly lower reaction mass efficiency and...... environmental impact, mainly derived from the production of raw materials. In comparison to the enzyme-catalyzed process, the chemical process uses approximately 60% more energy, about 16% more mass (excluding water), has double the greenhouse gas (GHG) impact, and about 30% higher photochemical ozone creation...

  11. Variabilidade da Frequência Cardíaca

    Roque, Juliano Miguel Amado

    2009-01-01

    Este trabalho teve como objectivo estudar a variabilidade da frequência cardíaca e quais as causas que condicionam essa mesma variabilidade. Verificámos que a frequência cardíaca está dependente do sistema nervoso autónomo apesar de o coração apresentar uma actividade intrínseca capaz de fazer contrair o músculo cardíaco. O sistema nervoso autónomo tem a capacidade para aumentar a frequência cardíaca através do sistema nervoso simpático e de reduzir essa mesma frequência cardíaca através do s...

  12. Influence of Supplemental Dietary Poultry Fat, Phytase, and 25-Hydroxycholecalciferol on the Performance of Commercial Layers Inoculated Before or at the Onset of Lay with F-Strain Mycoplasma gallisepticum

    The effects of 2 levels of supplemental dietary poultry fat (PF) and the combination of PF, phytase (PHY) and 25-hydroxycholecalciferol (D3) on the performance of commercial layers inoculated with F-strain Mycoplasma gallisepticum (FMG) were investigated in 2 trials. Sham and FMG inoculations were ...

  13. Effects of Supplemental Dietary Phytase and 25-Hydroxycholecalciferol on the Performance Characteristics of Commercial Layers Inoculated before or at the Onset of Lay with the F-Strain of Mycoplasma gallisepticum

    The effects of dietary supplementation with phytase and 25-hydroxycholecalciferol on the performance characteristics of commercial layers that were inoculated prelay (12 wk of age) or at the onset of lay (22 wk of age) with F-strain Mycoplasma gallisepticum were assessed. Experimental layer diets, w...

  14. Influence of Supplemental Dietary Poultry Fat on the Digestive and Reproductive Organ Characteristics of Commercial Layers Inoculated Before or at the Onset of Lay with F-Strain Mycoplasma gallisepticum

    The effects of F-strain Mycoplasma gallisepticum (FMG) inoculation and 1.5 % supplemental dietary poultry fat (PF) on the digestive and reproductive organ characteristics of commercial layers at 58 wk of age were investigated. Sham and FMG inoculations were administered at 12 (before lay) and 22 (e...

  15. Influence of supplemental dietary poultry fat, phytase, and 25-hydroxycholecalciferol on the blood characteristics of commercial layers inoculated before or at the onset of lay with F-strain Mycoplasma gallisepticum

    The effects of 2 supplemental levels of dietary poultry fat (PF) and the combination of PF, phytase (PHY) and 25-hydroxycholecalciferol [25(OH)D] on the blood characteristics of commercial layers inoculated with F-strain Mycoplasma gallisepticum (FMG) were investigated in 2 trials. Sham and FMG ino...

  16. Design of a variant surface antigen-supplemented microarray chip for whole transcriptome analysis of multiple Plasmodium falciparum cytoadherent strains, and identification of strain-transcendent rif and stevor genes

    Bozdech Zbynek

    2011-06-01

    Full Text Available Abstract Background The cytoadherence of Plasmodium falciparum is thought to be mediated by variant surface antigens (VSA, encoded by var, rif, stevor and pfmc-2tm genes. The last three families have rarely been studied in the context of cytoadherence. As most VSA genes are unique, the variability among sequences has impeded the functional study of VSA across different P. falciparum strains. However, many P. falciparum genomes have recently been sequenced, allowing the development of specific microarray probes for each VSA gene. Methods All VSA sequences from the HB3, Dd2 and IT/FCR3 genomes were extracted using HMMer software. Oligonucleotide probes were designed with OligoRankPick and added to the 3D7-based microarray chip. As a proof of concept, IT/R29 parasites were selected for and against rosette formation and the transcriptomes of isogenic rosetting and non-rosetting parasites were compared by microarray. Results From each parasite strain 50-56 var genes, 125-132 rif genes, 26-33 stevor genes and 3-8 pfmc-2tm genes were identified. Bioinformatic analysis of the new VSA sequences showed that 13 rif genes and five stevor genes were well-conserved across at least three strains (83-100% amino acid identity. The ability of the VSA-supplemented microarray chip to detect cytoadherence-related genes was assessed using P. falciparum clone IT/R29, in which rosetting is known to be mediated by PfEMP1 encoded by ITvar9. Whole transcriptome analysis showed that the most highly up-regulated gene in rosetting parasites was ITvar9 (19 to 429-fold up-regulated over six time points. Only one rif gene (IT4rifA_042 was up-regulated by more than four fold (five fold at 12 hours post-invasion, and no stevor or pfmc-2tm genes were up-regulated by more than two fold. 377 non-VSA genes were differentially expressed by three fold or more in rosetting parasites, although none was as markedly or consistently up-regulated as ITvar9. Conclusions Probes for the VSA of

  17. The "ACA Code of Ethics": Articulating Counseling's Professional Covenant

    Ponton, Richard F.; Duba, Jill D.

    2009-01-01

    The "ACA Code of Ethics" (American Counseling Association, 2005) is an articulation of the ever-changing relationship between counseling professionals and society. It provides clear parameters of behaviors to meet the changing needs of the people counselors are called to serve. This article reviews the 2005 "Code" as both a statement of counselor…

  18. Patologia cardíaca associada à tirotoxicose

    Cruz, Maria Raquel Marques Rodrigues Moreira da

    2009-01-01

    O trabalho que se apresenta resulta de uma revisão bibliográfica acerca da patologia cardíaca associada à tirotoxicose, que pretende reunir a informação mais relevante acerca do tema. O objectivo deste trabalho é avaliar em que medida as doenças cardíacas se encontram associadas a doenças da tiróide, nomeadamente à tirotoxicose. A glândula tiroideia é um dos maiores órgãos especializados em função endócrina do corpo humano. As hormonas tiroideias contêm 59-65% de iodo. ...

  19. ACA phase calibration scheme with the ALMA water vapor radiometers

    Asaki, Yoshiharu; Matsushita, Satoki; Morita, Koh-Ichiro; Nikolic, Bojan

    2012-09-01

    In Atacama Large Millimeter/submillimeter Array (ALMA) commissioning and science verification we have conducted a series of experiments of a novel phase calibration scheme for Atacama Compact Array (ACA). In this scheme water vapor radiometers (WVRs) devoted to measurements of tropospheric water vapor content are attached to ACA’s four total-power array (TP Array) antennas surrounding the 7 m dish interferometer array (7 m Array). The excess path length (EPL) due to the water vapor variations aloft is fitted to a simple two-dimensional slope using WVR measurements. Interferometric phase fluctuations for each baseline of the 7 m Array are obtained from differences of EPL inferred from the two-dimensional slope and subtracted from the interferometric phases. In the experiments we used nine ALMA 12-m antennas. Eight of them were closely located in a 70-m square region, forming a compact array like ACA. We supposed the most four outsiders to be the TP Array while the inner 4 antennas were supposed to be the 7 m Array, so that this phase correction scheme (planar-fit) was tested and compared with the WVR phase correction. We estimated residual root-mean-square (RMS) phases for 17- to 41-m baselines after the planar-fit phase correction, and found that this scheme reduces the RMS phase to a 70 - 90 % level. The planar-fit phase correction was proved to be promising for ACA, and how high or low PWV this scheme effectively works in ACA is an important item to be clarified.

  20. Application of serum anticardiolipin antibody (ACA) determination with ELISA for detection of intra-uterine growth retardation (IUGR)

    Objective: To explore the interrelationship between presence of serum ACA and development of IUGR. Methods: Serum ACA contents were examined with ELISA in 5330 apparently normal pregnant women. The placentae in 16 pregnancies with IUGR and positive ACA were examined with immunofluorescence microscopy. Results: Among the 5330 pregnant women there were 144 with positive ACA (2.70%), in whom there were 22 IUGR cases (22/144, 15.28% ). The rate of IUGR in the remaining ACA negative women was only 1.77% (92/5186), the difference being very significant (P<0.01 ). ACA IgG was positive in 5 of the IUGR neonates, All the placental tissues examined with immunofluorescence microscopy showed positive immunoglobulin fluorescence antibody and complement discoloration. Conclusion: Positive ACA is one of the causative factors of development of IUGR and determination of ACA in pregnant women was helpful for early detection of IUGR. (authors)

  1. New Mandates and Imperatives in the Revised "ACA Code of Ethics"

    Kaplan, David M.; Kocet, Michael M.; Cottone, R. Rocco; Glosoff, Harriet L.; Miranti, Judith G.; Moll, E. Christine; Bloom, John W.; Bringaze, Tammy B.; Herlihy, Barbara; Lee, Courtland C.; Tarvydas, Vilia M.

    2009-01-01

    The first major revision of the "ACA Code of Ethics" in a decade occurred in late 2005, with the updated edition containing important new mandates and imperatives. This article provides interviews with members of the Ethics Revision Task Force that flesh out seminal changes in the revised "ACA Code of Ethics" in the areas of confidentiality,…

  2. A Critical Examination of the Assessment Analysis Capabilities of OCLC ACAS

    Lyons, Lucy E.

    2005-01-01

    Over 500 libraries have employed OCLC's iCAS and its successor Automated Collection Assessment and Analysis Services (ACAS) as bibliometric tools to evaluate monograph collections. This examination of ACAS reveals both its methodological limitations and its feasibility as an indicator of collecting patterns. The results can be used to maximize the…

  3. Caquexia associada à insuficiência cardíaca

    Marina Politi Okoshi

    2013-05-01

    Full Text Available Pacientes com insuficiência cardíaca frequentemente desenvolvem estado de caquexia, que constitui fator independente de redução da sobrevida. Caquexia pode ser diagnosticada quando ocorre perda de peso corporal maior que 6% do peso habitual, na ausência de outras doenças. Embora sua fisiopatologia não esteja completamente esclarecida, vários fatores parecem estar envolvidos, como diminuição da ingestão alimentar, anormalidades do trato gastrointestinal, ativação imunológica e neuro-hormonal e alteração da relação entre processos anabólicos e catabólicos. Como não há terapia específica para a caquexia associada à insuficiência cardíaca, o tratamento baseia-se no suporte nutricional, bloqueio neuro-hormonal, controle do edema e anemia e exercícios físicos. Fármacos com propriedades imunomodulatórias e anabólicas encontram-se em investigação clínica e experimental.

  4. Signature of MoU between CERN and Australian Collaboration for Accelerator Science (ACAS); Roger Rassool, ACAS Director; Mark Boland, ACAS Deputy Director; Jean-Pierre Delahaye, CLIC Project Leader; in the presence of Rolf Heuer, Director-General and Emmanuel Tsesmelis, Adviser for Australia

    Maximilien Brice

    2010-01-01

    Signature of MoU between CERN and Australian Collaboration for Accelerator Science (ACAS); Roger Rassool, ACAS Director; Mark Boland, ACAS Deputy Director; Jean-Pierre Delahaye, CLIC Project Leader; in the presence of Rolf Heuer, Director-General and Emmanuel Tsesmelis, Adviser for Australia

  5. Calcium supplements

    ... this page: //medlineplus.gov/ency/article/007477.htm Calcium supplements To use the sharing features on this page, please enable JavaScript. WHO SHOULD TAKE CALCIUM SUPPLEMENTS? Calcium is an important mineral for the ...

  6. The effect of supplementation with polysaccharides, nucleotides, acidifiers and Bacillus strains in fish meal and soy bean based diets on growth performance in juvenile turbot (Scophthalmus maximus)

    Fuchs (geb. Hemsing), Vanessa; Schmidt, Jan; Slater, Matthew James; Zentek, Jürgen; Buck, Bela H.; Steinhagen, Dieter

    2015-01-01

    The investigation and application of a wide range of dietary supplements, such as probiotics, prebiotic and other additives, are increasingly popular in aquaculture research and practice. To date few studies have attempted to quantify the value of commercially available additives in improving growth performance of juvenile turbot (Scophthalmus maximus) and in compensating potential growth reduction resulting from high levels of plant protein (PP) in carnivorous fish diets. Two experiments ...

  7. Sports Supplements

    ... sports supplements often use persuasive before and after pictures that make it look easy to get a muscular, toned body. But the goal of supplement advertisers is to make money by selling more supplements, and many claims may be misleading. Teens and kids may seem like an easy sell ...

  8. Ein empirischer Validitätsvergleich der ACA, des ASE und des PCPM

    Meissner, Martin; Decker, Reinhold; Adam, Nadine

    2011-01-01

    The increasing complexity of many products makes high demands on methods used for measuring consumer preferences. In such cases, practitioners frequently use Adaptive Conjoint Analysis (ACA). However, compositional approaches also proved to be efficient. Recently, Srinivasan and Netzer (2011...

  9. Stochastic estimation of the Frobenius norm in the ACA convergence criterion

    Heldring, Alexander; Úbeda Farré, Eduard; Rius Casals, Juan Manuel

    2015-01-01

    The adaptive cross approximation (ACA) algorithm has been used in many fast Integral Equation solvers for electromagnetic Radiation and Scattering problems. It efficiently computes a low rank approximation to the interaction matrix between mutually distant parts of a scattering object. The ACA is an iterative algorithm that needs an accurate and efficient convergence criterion. The evaluation of this criterion may consume a considerable part of the computational resources. This communication ...

  10. Glutamine supplementation

    Wernerman, Jan

    2011-01-01

    Intravenous glutamine supplementation is standard care when parenteral nutrition is given for critical illness. There are data of a reduced mortality when glutamine supplementation is given. In addition, standard commercial products for parenteral nutrition do not contain any glutamine due to glutamine instability in aqueous solutions. For the majority of critical ill patients who are fed enterally, the available evidence is insufficient to recommend glutamine supplementation. Standard formul...

  11. Supplemental Colleges

    Department of Homeland Security — The Supplemental Colleges layer attempts to capture additional Post Secondary Education campuses of colleges and universities associated with a single campus listed...

  12. Evaluation of Rice Bran and Wheat Bran as Supplemental Feed Compared to a Commercial Feed for Monoculture of GIFT Strain of Tilapia (Oreochromis niloticus) in Bangladesh

    Hossain, Md. Sakhawat; HOSSAIN Md. Arshad; MAMUN Md. Abdullah-Al; ALI Md. Zulfikar; BULBUL Mahbuba; Koshio, Shunsuke; Kader, Md. Abdul; コシオ, シュンスケ; 越塩, 俊介

    2011-01-01

    A feeding trial was conducted to evaluate the effect of rice bran and wheat bran as supplementary feed in comparison to a commercial feed for monoculture of GIFT strain of tilapia (Oreochromis niloticus). Four experimental diets such as commercial tilapia diet, rice bran, wheat bran, and a mixture of rice bran and wheat bran (50:50) were assigned to four treatments designated as T1, T2, T3 and T4 respectively. Triplicate groups of fish (initial mean weight 2.80 g) were delivered the test diet...

  13. Spectroscopic and structural impact of a stem base-pair change in DNA hairpins: GTTC-ACA-GAAC versus GTAC-ACA-GTAC

    Lamoureux, Michèle; Patard, Louis; Hernandez, Belen; Couesnon, Thierry; Santini, Guillaume P. H.; Cognet, Jean A. H.; Gouyette, Catherine; Cordier, Christine

    2006-09-01

    Successive investigations over the last decade have revealed and confirmed a stable loop closure in a family of d-[GTAC-5Pur6N7N-GTAC] hairpins, where 5Pur6N7N is a AAA, GAG and AXC loop (X being any nucleotide). The trinucleotide loop is characterized by a well defined 5Pur-7N mispairing mode, and by upfield chemical shifts for three sugar protons of the apical nucleotide 6N. The GTTC-ACA-GAAC DNA hairpin, of interest for its likely involvement in Vibrio cholerae genome mutations, has now been investigated. The GTAC-ACA-GTAC DNA hairpin has also been studied because it is intermediate between the other structures, as it contains the loop of the hairpin under consideration and the stem of the above family. The two hairpins with the ACA loop are stable. They show the same mispairing mode and similar upfield shifts as the previous family, but GTTC-ACA-GAAC seems to be slightly less compact than any other. GTTC-ACA-GAAC is remarkable in that it exhibits a B II character for the phosphate-ester conformation at 8Gp9A, together with a swing of the upper hairpin into the major groove that, in particular, brings 6CH1' roughly as close to 7AH2 as to 6CH6. These unexpected structural features are qualitatively deduced from 1H and 31P NMR spectra, and confirmed by Raman spectroscopy. This comparative study shows that not only the loop sequence but also the stem sequence may control hairpin structures.

  14. Effect of insoluble fiber supplementation applied at different ages on digestive organ weight and digestive enzymes of layer-strain poultry.

    Yokhana, J S; Parkinson, G; Frankel, T L

    2016-03-01

    Two experiments were conducted to study effects of dietary insoluble fiber (IF) on digestive enzyme function in layer poultry. In Experiment 1, 8 wk old pullets were fed a control diet (Group C) or a diet (Group IF) supplemented with 1% IF (Arbocel RC). After 5 wk, 6 pullets per group were killed and organ samples collected. The remaining pullets in Group C were divided into two groups: half were fed the control diet (Group C) and half were given the IF diet (Group C-IF). Similarly, half the pullets in Group IF continued on the IF diet (Group IF) and half on the control diet (Group IF-C). At 10 wk, organ samples were collected. BW at wk 5 (IF, 1364.8 g; C, 1342.9 g) and 10 wk (IF, 1678.1 g; IF-C, 1630.5 g; C-IF, 1617.1 g; C, 1580.4 g) were not different. At wk 5, the relative proventricular weight (0.41 g/100 g BW) and activities of pepsin (75.3 pepsin units/g proventriculus/min) and pancreatic general proteolytic activity (GP) (122.9 μmol tyrosine produced/g tissue) were greater (P Pancreatic GP activity was greater (P enzyme activities in IF pullets may contribute to an improvement in feed utilization. PMID:26574026

  15. Dietary Supplements

    ... are not intended to treat, diagnose, prevent, or cure diseases. Do not take supplements instead of your ... Partners Women's Health Topics Mammography Women and Diabetes HPV, HIV, Birth Control Heart Health for Women Pregnancy ...

  16. Supplemental Oxygen

    ... Disease Lookup > COPD > Diagnosing and Treating COPD Supplemental Oxygen Sometimes with chronic obstructive pulmonary disease (COPD), lung ... in people with severe lung disease Three Ways Oxygen Therapy Is Supplied Compressed oxygen gas and liquid ...

  17. Nepali Supplements.

    Peace Corps, Washington, DC.

    This volume is intended as a supplement to Nepali language instruction. It contains songs, numerals, dialogues in Devanagari script, a Nepali-English, English-Nepali glossary, and an English-Nepali surveyor technical glossary. (AM)

  18. Detection and Identification of Probiotic Lactobacillus plantarum Strains by Multiplex PCR Using RAPD-Derived Primers

    Alex Galanis; Yiannis Kourkoutas; Chrysoula C. Tassou; Nikos Chorianopoulos

    2015-01-01

    Lactobacillus plantarum 2035 and Lactobacillus plantarum ACA-DC 2640 are two lactic acid bacteria (LAB) strains that have been isolated from Feta cheese. Both display significant potential for the production of novel probiotic food products. The aim of the present study was the development of an accurate and efficient method for the molecular detection and identification of the above strains in a single reaction. A multiplex PCR assay was designed for each strain, based on specific primers de...

  19. Estimating the Counterfactual: How Many Uninsured Adults Would There Be Today Without the ACA?

    Blumberg, Linda J; Garrett, Bowen; Holahan, John

    2016-01-01

    Time lags in receiving data from long-standing, large federal surveys complicate real-time estimation of the coverage effects of full Affordable Care Act (ACA) implementation. Fast-turnaround household surveys fill some of the void in data on recent changes to insurance coverage, but they lack the historical data that allow analysts to account for trends that predate the ACA, economic fluctuations, and earlier public program expansions when predicting how many people would be uninsured without comprehensive health care reform. Using data from the Current Population Survey (CPS) from 2000 to 2012 and the Health Reform Monitoring Survey (HRMS) data for 2013 and 2015, this article develops an approach to estimate the number of people who would be uninsured in the absence of the ACA and isolates the change in coverage as of March 2015 that can be attributed to the ACA. We produce counterfactual forecasts of the number of uninsured absent the ACA for 9 age-income groups and compare these estimates with 2015 estimates based on HRMS relative coverage changes applied to CPS-based population estimates. As of March 2015, we find the ACA has reduced the number of uninsured adults by 18.1 million compared with the number who would have been uninsured at that time had the law not been implemented. That decline represents a 46% reduction in the number of nonelderly adults without insurance. The approach developed here can be applied to other federal data and timely surveys to provide a range of estimates of the overall effects of reform. PMID:27076474

  20. Molecular Cloning and Expression of a New Allergen of Acacia farnesiana (Aca f 2

    Najmeh Sepahi

    2015-10-01

    Full Text Available Inhalation of pollens from different species of Acacia is a common cause of respiratory allergy in tropical areas of the world. Acacia farnesiana is commonly used as street trees in towns and ornamental shade trees in parks and gardens throughout arid and semi-arid regions of Asia. This study aimed to produce and purify the A. farnesiana pollen profilin (Aca f 2 and evaluate its nucleotide sequence homology with profilins of common allergenic plants to predict allergenic cross-reactivity.Thirty-nine patients who were allergic to Acacia pollens were included in the study. Cloning of Acacia profilin-coding sequence was performed by polymerase chain reaction using primers from Acacia pollen RNA. The cDNA of Acacia pollen profilin was then expressed in Escherichia coli using pET-21b(+ vector and purified by metal affinity chromatography. Immunoreactivity of the recombinant Acacia profilin (rAca f 2 was evaluated by specific ELISA, immunoblotting, and inhibition assays.The coding sequence of the Acacia profilin cDNA was recognized as a 399-bp open reading frame encoding 133 amino acid residues. Eighteen patients (18/39, 46.15% had significant specific IgE levels against Aca f 2. Immunodetection and inhibition assays indicated that purified Aca f 2 might be the same as that in the crude extract.Aca f2, the first allergen from A. farnesiana pollen, was identified as belonging to the family ofprofilins. The amino acid sequence homology analysis showed high cross-reactivity betweenAca f 2 and other profilins from botanically unrelated common allergenic plants.

  1. Molecular Cloning and Expression of a New Allergen of Acacia farnesiana (Aca f 2).

    Sepahi, Najmeh; Khodadadi, Ali; Assarehzadegan, Mohammad-Ali; Amini, Akram; Zarinhadideh, Farnoosh; Ali-Sadeghi, Hosein

    2015-08-01

    Inhalation of pollens from different species of Acacia is a common cause of respiratory allergy in tropical areas of the world. Acacia farnesiana is commonly used as street trees in towns and ornamental shade trees in parks and gardens throughout arid and semi-arid regions of Asia. This study aimed to produce and purify the A. farnesiana pollen profilin (Aca f 2) and evaluate its nucleotide sequence homology with profilins of common allergenic plants to predict allergenic cross-reactivity. Thirty-nine patients who were allergic to Acacia pollens were included in the study. Cloning of Acacia profilin-coding sequence was performed by polymerase chain reaction using primers from Acacia pollen RNA. The cDNA of Acacia pollen profilin was then expressed in Escherichia coli using pET-21b(+) vector and purified by metal affinity chromatography. Immunoreactivity of the recombinant Acacia profilin (rAca f 2) was evaluated by specific ELISA, immunoblotting, and inhibition assays. The coding sequence of the Acacia profilin cDNA was recognized as a 399-bp open reading frame encoding 133 amino acid residues. Eighteen patients (18/39, 46.15%) had significant specific IgE levels against Aca f 2. Immunodetection and inhibition assays indicated that purified Aca f 2 might be the same as that in the crude extract. Aca f2, the first allergen from A. farnesiana pollen, was identified as belonging to the family of profilins. The amino acid sequence homology analysis showed high cross-reactivity between Aca f 2 and other profilins from botanically unrelated common allergenic plants. PMID:26547704

  2. Toward a conceptual understanding of acute cultural adaptation: A preliminary examination of ACA in female swimming

    Ryba, Tatiana; Haapanen, Saara; Mosek, Shwiko; Ng, Kwok

    2012-01-01

    This paper considers a novel approach to researching adaptation in transnational athletes. The first part introduces a conceptualisation of acute cultural adaptation (ACA), which extends the current literature in sport psychology by offering original insights into mechanisms underpinning adaptive...... psychological needs. The second part of the paper engages the conceptualisation of ACA to make sense of the adaptive processes as experienced by female swimmers from Finland during their training camp in Australia. The study’s findings highlight relatedness as a discursive cultural space, offering a starting...... point for examining the role of culture in psychological functions during short-term relocation....

  3. Os efeitos da trimetazidina na variabilidade da frequência cardíaca (VFC) em pacientes com insuficiência cardíaca Los efectos de la trimetazidina en la variabilidad de la frecuencia cardíaca (VFC) en pacientes con insuficiencia cardíaca The effects of trimetazidine on heart rate variability in patients with heart failure

    Yilmaz Gunes; Unal Guntekin; Mustafa Tuncer; Musa Sahin

    2009-01-01

    FUNDAMENTO: Tem sido demonstrado que diminuições na variabilidade da frequência cardíaca (VFC) estão relacionadas com o prognóstico na insuficiência cardíaca (IC). A administração crônica de trimetazidina, além da terapia convencional, tem melhorado a classe funcional e a função ventricular esquerda de pacientes com IC. OBJETIVO: Avaliar os efeitos da trimetazidina na VFC em pacientes com IC de origem isquêmica, recebendo tratamento otimizado. MÉTODOS: Trimetazidina 20 mg 3 vezes/dia foi adic...

  4. Registro Nacional de Internación por Insuficiencia Cardíaca

    Raúl Borracci; Fernando Botto; María Marturano; Susana Fernández; Javier Guetta; Patricia Blanco; Leandro Rodríguez; Enrique Fairman; Jorge Thierer; Consejo de Emergencias Cardiovasculares. Área de Investigación. Sociedad Argentina de Cardiología

    2009-01-01

    IntroducciónLa insuficiencia cardíaca representa una de las principales causas de internación con una tasa elevada de complicaciones y cuyo enfoque no parece que haya mejorado en los últimos años.ObjetivosConocer el perfil epidemiológico y clínico, analizar las medidas terapéuticas y la evolución durante la internación y a los 3 meses de pacientes admitidos por insuficiencia cardíaca descompensada.Material y métodosRegistro prospectivo, multicéntrico de pacientes internados por insuficiencia ...

  5. Perils ahead: employers cheer mandate's delay, but move leaves ACA open to new attacks.

    Block, Jonathan; Daly, Rich

    2013-07-01

    When the Obama administration announced it was delaying enforcement of the employer mandate in the ACA for one year, employer groups celebrated. But others had some troubling questions. "One has to hope, however, that the administration has thought through the ramifications of this delay for the other provisions," says Tim Jost, left, a law professor at Washington & Lee University. PMID:23878915

  6. Ethical Challenges in a Complex World: Highlights of the 2005 ACA Code of Ethics

    Kocet, Michael M.

    2006-01-01

    Being an effective counselor includes having knowledge of and the ability to integrate a code of ethics into one's professional practice. This article addresses some of the highlights of the changes in the 2005 ACA [American Counseling Association] Code of Ethics such as end-of-life issues, boundaries and relationships, and multicultural and…

  7. Glutamine supplementation.

    Wernerman, Jan

    2011-01-01

    Intravenous glutamine supplementation is standard care when parenteral nutrition is given for critical illness. There are data of a reduced mortality when glutamine supplementation is given. In addition, standard commercial products for parenteral nutrition do not contain any glutamine due to glutamine instability in aqueous solutions. For the majority of critical ill patients who are fed enterally, the available evidence is insufficient to recommend glutamine supplementation. Standard formulation of enteral nutrition contains some glutamine: 2-4 g/L. However, this dose is insufficient to normalize glutamine plasma concentration.Plasma concentration of glutamine is low in many patients with critical illness and a low level is an independent risk factor for mortality. A low plasma glutamine concentration is the best indicator of glutamine depletion. Data are emerging about how the endogenous production of glutamine is regulated. We know that skeletal muscle is the major producer of glutamine and that a part of the profound depletion of skeletal muscle seen in critical illness is a reflection of the need to produce glutamine.Glutamine is utilized in rapidly dividing cells in the splanchnic area. Quantitatively most glutamine is oxidized, but the availability of glutamine in surplus is important for the de novo synthesis of nucleotides and necessary for cell division and protein synthesis. More knowledge about the regulation of the endogenous production of glutamine is needed to outline better guidelines for glutamine supplementation in the future. PMID:21906372

  8. The ACA training programme to improve communication between general practitioners and their palliative care patients: development and applicability

    Slort Willemjan

    2012-06-01

    Full Text Available Abstract We describe the development of a new training programme on GP-patient communication in palliative care, and the applicability to GPs and GP Trainees. This ‘ACA training programme’ focuses on  A vailability of the GP for the patient,  C urrent issues that should be raised by the GP, and  A nticipating various scenarios. Evaluation results indicate the ACA training programme to be applicable to GPs and GP Trainees. The ACA checklist was appreciated by GPs as useful both in practice and as a learning tool, whereas GP Trainees mainly appreciated the list for use in practice.

  9. Značajke prostorne distribucije sušaca u bukovo-jelovoj šumi

    Pernar, Renata; Seletković, Ante; Ančić, Mario; Sučić, Jelena

    2011-01-01

    Utvrđivanje prostornoga rasporeda oštećenih stabala i sušaca te njihovo praćenje jedan je od prioriteta potrajnoga gospodarenja. Inventarizacija sušaca interpretacijom infracrvenih kolornih (ICK) aerosnimaka i GIS-a omogućuje učinkovito prebrojavanje (detekciju) i prostornu distribuciju (kartiranje) sušaca. Interpretacijom ICK aerosnimaka može se ustanoviti trenutačno stanje, tj. u kratkom razdoblju dobiti objektivan uvid u stanje šuma (baza podataka), a kartiranjem na digitalnom ortofotu (DO...

  10. 犬钩虫C型凝集素AcaCTL-1基因的克隆及表达%Cloning and expression of a C-type lectin(AcaCTL-1)gene from Ancylostoma caninum

    邓莉; 金娴; 何庆丰; 许琴英; 吴亚敏; 彭礼飞

    2010-01-01

    目的 分离鉴定犬钩虫C型凝集素AcaCTL-1基因,并在大肠埃希菌中表达.方法 根据EST序列设计引物,用RT-PCR及3,(RACE技术扩增获得AcaCTL-1伞长cDNA序列,并对其进行初步生物信息学分析;将AcaCTL-l成熟肽编码序列克隆、连接到表达载体pET32a.构建重组质粒pET32a/AcaCTL-1;在大肠埃希菌BL21(DE3)中诱导表达重组蛋白,SDS-PAGE分析表达情况,Ni亲和层析纯化可溶性蛋白.结果 成功克隆了AcaCTL-1全长cDNA序列,其最大开放阅读框由525 bp组成,预测编码174个氨基酸残基组成的蛋白,含17个氨基酸组成的信号肽,为C型凝集索家族蛋白成员;构建pET32a/AcaCTL-1莺组质粒,并在大肠埃希菌中高效表达.表达产物多以包涵体形式存在,小部分为可溶性蛋白.结论 成功克隆并表达了犬钩虫C型凝集素AcaCTL-基因,为进一步了解AcaCTL-1的功能奠定了基础.

  11. Despite Resources From The ACA, Most States Do Little To Help Addiction Treatment Programs Implement Health Care Reform

    Andrews, Christina; Abraham, Amanda; Grogan, Colleen M.; Pollock, Harold A.; Bersamira, Clifford; Humphreys, Keith; Friedmann, Peter

    2015-01-01

    The Affordable Care Act (ACA) dramatically expands health insurance for addiction treatment and provides unprecedented opportunities for service growth and delivery model reform. Yet most addiction treatment programs lack the staffing and technological capabilities to respond successfully to ACA-driven system change. In light of these challenges, we conducted a national survey to examine how Single State Agencies for addiction treatment—the state governmental organizations charged with overse...

  12. Study on the correlationship among serum ACA, hs-CRP and Hcy levels in patients with cerebral infarction

    Objective: To study the changes of and correlationship among serum anti-cardiolipin antibody (ACA), hs-CRP and Hcy levels in patients with cerebral infarction. Methods: Serum ACA (with ELISA), hs-CRP(with RIA) and Hcy(with CLIA) levels were measured in 210 patients with cerebral infarction and 30 controls. Results: The serum ACA, hs-CRP and Hcy contents in the patients with cerebral infarction were significantly higher than those in the controls. Serum hs-CRP and Hcy levels in the patients were mutually positively correlated (r=0.714). Serum ACA levels in the patients were also positively correlated with serum hs-CRP levels(r=0.893) and Hcy levels(r=0.597). Conclusion: High serum ACA, hs-CRP and Hcy levels were independent risk factors in the development of cerebral infarction. Combined determination of serum ACA, hs-CRP and Hcy levels was helpful for early diagnosis in patients with cerebral infarction. (authors)

  13. Nutritional supplements

    Petersen, Gry Bjerg; Andersen, Jens Rikardt

    2015-01-01

    Background: Several studies have indicated that cancer patients have significantly altered taste sensitivity without specifying the preferences. One of the related problems is low compliance to nutritional therapy with oral nutritional supplements (ONS) in patients suffering severe weight loss....... Objective: We wanted to investigate taste preferences and sensoric characteristics among three usually used ONS in patients with malignant haematological disease during cytotoxic treatment. Design: Tested drinks were: Protin® (protein-enriched-milk, ARLA), Nutridrink® (NUTRICIA) and hospital-produced drink...

  14. Triagem sorológica para doença celíaca em adolescentes

    Maria Ester Pereira da Conceição-Machado

    2015-03-01

    Full Text Available OBJETIVO: Este estudo objetivou identificar a soroprevalência da doença celíaca em adolescentes de escolas públicas da cidade de Salvador, Bahia. MÉTODO: Trata-se de um estudo transversal com amostra probabilística de 1.213 adolescentes de 11 a 17 anos, de ambos os sexos. O índice de massa corporal foi utilizado para o diagnóstico do estado nutricional, adotando-se os percentis segundo idade e sexo, propostos pela World Health Organization. O anticorpo anti-transglutaminase humana da classe imunoglobulina A (anti-tTG-IgA foi adotado como teste sorológico para triagem da doença celíaca e foi determinado pela técnica do ensaio imunoabsorvente ligado à enzima (ELISA. Foi realizada análise descritiva, utilizando-se a proporção e a média (desvio padrão. RESULTADOS: O sexo feminino predominou entre os adolescentes, e a maioria encontrava-se com adequado estado nutricional. O anticorpo anti-tTG-IgA foi positivo em 6/1.213 (0,49% adolescentes. CONCLUSÃO: A soroprevalência de doença celíaca entre os adolescentes estudados foi 0,49%. Novas investigações são necessárias para confirmar a prevalência de doença celíaca nessa faixa etária.

  15. Disorders of Accommodative Convergation and Accommodation (AC/A) Relations at Traumatic Brain Injury

    Serdarevic, Raif

    2015-01-01

    Introduction: Accommodative Convergence/Accommodation (AC/A) ratio is constant at one and the same person in the course of life, i.e. the same ratio accommodative convergence monitor any change in accommodation measured in diopters. Such a perfect relationship is possible if there are no refractive anomalies in both eyes and oculomotor imbalance of eye muscles. Material and methods: We are examined 50 patients with close brain injury, and patients which had problems with near vision, accommod...

  16. The cytotoxic effects a of ACA1 on human melanoma cell line

    R. Yaraie; M.R. Jalali Nadoushan; Naseri, M.; S. Shahrokhi; T. Ghazanfari; Kardar, M.

    2006-01-01

    Background and purpose: Different methods such as surgery, chemotherapy, radiotherapy, hormone therapy and immunotherapy are used for treatment of melanoma cancer. Unfortunately they don't always have desirable results and they may have unfavorable side effects. Researchers try to find new, more effective drugs with low side effects. In this study we evaluated the cytotoxic effect of ACA-1, a water extract of a traditional Iranian medicinal herbs on a melanoma cell line SKMEL-3.Materials and ...

  17. Novi nalazi recentnih ramenonožaca (Brachiopoda) u istočnom dijelu sjevernog Jadrana

    Legac, Mirjana

    2012-01-01

    Navode se podaci za četiri vrste ramenonožaca nađenih na tri nova nalazišta: u uzorku sedimenta iz morske špilje Medova buža s jednog metra dubine (Novocrania turbinata, Argyrotheca cuneata i Joania cordata), s obraštaja fragmenta amfore u Velom kolu na dubini od 25 m (Argyrotheca cuneata i Megathiris detruncata) otok Rab i u Unijskom kanalu s dubine od 52 m (Joania cordata).

  18. Molecular Cloning and Expression of a New Allergen of Acacia farnesiana (Aca f 2)

    Najmeh Sepahi; Ali Khodadadi; MohammadAli Assarehzadegan; Akram Amini; Farnoosh Zarinhadideh; Hosein Ali-Sadeghi

    2015-01-01

    Inhalation of pollens from different species of Acacia is a common cause of respiratory allergy in tropical areas of the world. Acacia farnesiana is commonly used as street trees in towns and ornamental shade trees in parks and gardens throughout arid and semi-arid regions of Asia. This study aimed to produce and purify the A. farnesiana pollen profilin (Aca f 2) and evaluate its nucleotide sequence homology with profilins of common allergenic plants to predict allergenic cross-reactivity.Thi...

  19. Complicações cardíacas em cirurgia vascular

    Karla Scamardi Martins Pereira

    2016-01-01

    Full Text Available Resumo Contexto Aproximadamente 60% dos pacientes portadores de doença arterial oclusiva crônica periférica têm doença coronariana grave, sendo que a principal causa de morte no pós-operatório de cirurgia vascular de grande porte é o infarto agudo do miocárdio. Objetivos Determinar a prevalência da doença coronariana em pacientes submetidos a cirurgia vascular eletiva de grande porte e sua relação com as complicações cardiológicas pós-operatórias. Métodos Foram analisados 200 pacientes submetidos a cirurgia vascular arterial eletiva: doença obstrutiva carotídea, aortoilíaca e femoropoplítea distal e doença aneurismática de aorta abdominal e de artérias ilíacas. Os pacientes constituíram três grupos: grupo I, sem doença coronariana; grupo II, com doença coronariana assintomática; e grupo III, com doença coronariana sintomática. As complicações cardiológicas consideradas foram infarto agudo do miocárdio fatal e não fatal, insuficiência cardíaca congestiva, choque cardiogênico, fibrilação atrial aguda e outras arritmias. Resultados Complicações cardíacas ocorreram em 11 pacientes (5,5%: três infartos agudos do miocárdio não fatais (1,5% sempre em pacientes do grupo III. A complicação cardíaca mais frequente foi arritmia (exceto fibrilação atrial ocorrida em cinco (2,5% pacientes, sendo três do grupo II. A mortalidade precoce foi de nove pacientes (4,5%. Apenas uma morte foi decorrente de problema cardíaco: choque cardiogênico em paciente do grupo III. Conclusões A doença coronariana não foi preditora de óbito nos pacientes submetidos a cirurgia vascular periférica de grande porte. A sobrevida dos pacientes com ou sem doença coronariana não mostrou diferenças estatísticas.

  20. Diabetes and Dietary Supplements

    ... R S T U V W X Y Z Diabetes and Dietary Supplements: In Depth Share: On This ... health product or practice. Are dietary supplements for diabetes safe? Some dietary supplements may have side effects, ...

  1. Annual Statistical Supplement, 2011

    Social Security Administration — The Annual Statistical Supplement, 2011 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  2. Annual Statistical Supplement, 2003

    Social Security Administration — The Annual Statistical Supplement, 2003 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  3. Annual Statistical Supplement, 2004

    Social Security Administration — The Annual Statistical Supplement, 2004 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  4. Annual Statistical Supplement, 2008

    Social Security Administration — The Annual Statistical Supplement, 2008 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  5. Annual Statistical Supplement, 2002

    Social Security Administration — The Annual Statistical Supplement, 2002 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  6. Annual Statistical Supplement, 2001

    Social Security Administration — The Annual Statistical Supplement, 2001 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  7. Annual Statistical Supplement, 2006

    Social Security Administration — The Annual Statistical Supplement, 2006 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  8. Annual Statistical Supplement, 2000

    Social Security Administration — The Annual Statistical Supplement, 2000 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  9. Annual Statistical Supplement, 2009

    Social Security Administration — The Annual Statistical Supplement, 2009 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  10. Annual Statistical Supplement, 2010

    Social Security Administration — The Annual Statistical Supplement, 2010 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  11. Annual Statistical Supplement, 2007

    Social Security Administration — The Annual Statistical Supplement, 2007 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  12. Annual Statistical Supplement, 2015

    Social Security Administration — The Annual Statistical Supplement, 2015 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  13. Annual Statistical Supplement, 2014

    Social Security Administration — The Annual Statistical Supplement, 2014 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  14. Annual Statistical Supplement, 2005

    Social Security Administration — The Annual Statistical Supplement, 2005 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  15. Perspectivas futuras de tratamiento en la insuficiencia cardíaca: del trasplante de células a la regeneración cardíaca

    Prosper, F.; Herreros, J.; J. Barba

    2004-01-01

    En los últimos años hemos asistido a un interés creciente por el tratamiento de la insuficiencia cardíaca mediante el trasplante de células madre. Mientras que los estudios con células madre de músculo (mioblastos) se iniciaron hace más de 10 años, la posibilidad de que las células madre de la médula ósea tengan un enorme potencial de diferenciación y proliferación ha estimulado la investigación con otros tipos de células madre. Estos estudios experimentales han demost...

  16. Effects of Transgenic Tobacco Plants Expressing ACA Gene from Amaranthus caudatus on the Population Development of Myzus persicae

    GUOHong-Nian; JIAYan-Tao; ZHOUYong-Gang; ZHANGZhen-Shan; OUYANGQing; JIANGYing; TIANYing-Chuan

    2004-01-01

    To investigate the possible function of the agglutinin from Amaranthus caudatus L. (ACA) in plant defending against insect pests, ACA cDNA was cloned by RT-PCR and the 5' and 3' sequences were confirmed by rapid amplification of cDNA ends (RACE). The phloem-specific expression vector of ACA gene, pBCACAc, was constructed based on the plant binary vector pBC438 and transfered into tobacco plants via Agrobacterium-mediated transformation method. Results from PCR and Southern blotting analysis showed that AOA gene was integrated into the genomes of transformed plants and the transgene integration varied from one to four estimated copies per genome. Western blotting analysis indicated that ACA gene was transcribed and translated in the transgenic plants. The bioassay of Myzus persicae Sulzer on detached leaves demonstrated that the 78% transgenic tobacco plants displayed an average aphid-resistant rate of more than 75%. Some apterous progeny of M. persicae were found dead on the resistant plants. These results indicate that ACA gene should be an effective aphid-resistant gene and could be valuable for application in crop breeding for aphid resistance.

  17. Clinical significance of measurement serum Hcy, ACA and APN levels after treatment in patients with acute cerebral infarction

    Objective: To explore the clinical significance of changes of serum Hcy, ACA and APN levels after treatment in patients with acute cerebral infarction. Methods: Serum Hcy (with RIA), serum ACA, APN (with ELISA) levels were determined in 32 patients with acute cerebral infarction both before and after treatment as well as in 35 normal controls. Result: Before treatment the serum Hcy, ACA levels were significantly higher than those in controls (P<0.01), while the serum APN levels were significantly lower than those in controls (P<0.01), after treatment for 3 months, the levels remained still different from those in controls (P<0.05). Serum Hcy levels were positively correlated with serum ACA levels (r=0.6138, P<0.01), while the serum Hcy levels were negatively correlated with serum APN levels (r=-0.4218, P<0.05). Conclusion: serum Hcy, ACA and APN levels were closely related to the diseases process of acute cerebral infarction and determination of which were of great clinical importance. (authors)

  18. Cloning, expression and anticoagulant activities of anticoagulant peptide AcaNAP8 from Ancylostoma caninum%犬钩虫抗凝肽AcaNAP8的原核表达及其抗凝活性

    殷环; 邓莉; 王会兰; 吴亚敏; 彭礼飞

    2010-01-01

    目的 在大肠杆菌中重组表达犬钩虫抗凝肽AcaNAP8基因,并检测表达产物抗凝活性.方法 设计引物,将AcaNAP8成熟肽编码序列克隆、连接到原核表达载体pET32a,构建重组表达质粒;成功构建的重组表达质粒转化到大肠杆菌BL21(DE3)中用IPTG诱导表达,SDS-PAGE分析表达情况;诱导表达的重组蛋白用Ni亲和层析进行纯化;用凝血酶原时问(PT)和活化的部分凝血活酶时间(aPTTr)检测重组产物体外抗凝活性.结果 成功构建了pET32a/AcaNAP8原核表达重组质粒,在大肠杆菌中成功表达并获得了重组AcaNAP8,表达产物能明显延长PT及aPTT.结论 在大肠杆菌中成功表达了AcaNAP8融合蛋白,表达产物具有显著抗凝活性.该实验为进一步探讨AcaNAP8的作用机制及应用奠定了基础.

  19. Caquexia associada à insuficiência cardíaca Heart failure-induced cachexia

    Marina Politi Okoshi; Fernando G. Romeiro; Paiva, Sergio A.R.; Katashi Okoshi

    2013-01-01

    Pacientes com insuficiência cardíaca frequentemente desenvolvem estado de caquexia, que constitui fator independente de redução da sobrevida. Caquexia pode ser diagnosticada quando ocorre perda de peso corporal maior que 6% do peso habitual, na ausência de outras doenças. Embora sua fisiopatologia não esteja completamente esclarecida, vários fatores parecem estar envolvidos, como diminuição da ingestão alimentar, anormalidades do trato gastrointestinal, ativação imunológica e neuro-hormonal e...

  20. Prevalencia de hiperparatiroidismo secundario en pacientes con insuficiencia cardíaca estable

    Donaire Sansó, Gemma

    2016-01-01

    OBJETIVOS: El objetivo principal fue determinar la prevalencia de hiperparatiroidismo secundario (sHPT) y de déficit de vitamina D (DVD) en pacientes con insuficiencia cardíaca (IC) estable. Otros objetivos fueron: analizar la relación entre sHPT/DVD y los tratamientos de la IC, evaluar su relación con datos ecocardiográficos, clínicos y analíticos, la relación con otros biomarcadores y con la morbimortalidad, así como determinar los pacientes candidatos a realizar tratamiento del sHPT. ...

  1. Programa paciente experto en insuficiencia cardíaca en Navarra

    Iriarte Brasil, Nathalie

    2014-01-01

    La insuficiencia cardíaca supone una enfermedad con una alta repercusión en el sistema sanitario y en la calidad de vida de los pacientes. Actualmente se han desarrollado diversas iniciativas para abordar este problema, en las cuales se fomenta el autocuidado del paciente. Por esta razón se ha planteado como objetivo elaborar de forma teórica un programa de este tipo. Para este proceso se ha realizado una adaptación de la metodología de la Universidad de Standford. La principal característica...

  2. Registro Nacional de Internación por Insuficiencia Cardíaca

    Raúl Borracci

    2009-01-01

    Full Text Available IntroducciónLa insuficiencia cardíaca representa una de las principales causas de internación con una tasa elevada de complicaciones y cuyo enfoque no parece que haya mejorado en los últimos años.ObjetivosConocer el perfil epidemiológico y clínico, analizar las medidas terapéuticas y la evolución durante la internación y a los 3 meses de pacientes admitidos por insuficiencia cardíaca descompensada.Material y métodosRegistro prospectivo, multicéntrico de pacientes internados por insuficiencia cardíaca descompensada en 31 centros de todo el país que aceptaron la invitación a participar del registro. Se analizaron variables vinculadas con la presentación y la evolución hospitalaria y a los 90 días.ResultadosSe incluyeron 736 pacientes, mediana de edad 74 años (64-82, 41% mujeres, 75% hipertensos, 27% diabéticos, 20% infarto previo, 30% fibrilación auricular crónica, 17% insuficiencia renal crónica, 18% EPOC. Sólo el 29% era de etiología isquémico-necrótica. El 47% había tenido internación en el último año por insuficiencia cardíaca. Las causas de descompensación más frecuentes fueron infecciones, suspensión del tratamiento y transgresión alimentaria.Las formas graves de presentación (shock cardiogénico, edema agudo de pulmón, anasarca representaron el 30%. El 60% de los pacientes se internaron en área crítica. La mediana de permanencia fue de 7 (5-11 días. La mortalidad hospitalaria fue del 8%. A los 90 días, la reinternación fue del 24,5% y la mortalidad posalta fue del 12,8%.ConclusionesEl presente registro confirma que se trata de una población de edad avanzada con una incidencia alta de comorbilidades. Muchas descompensaciones ocurren por factores prevenibles. La tasa de complicaciones es elevada y no se redujo en la última década.REV ARGENT CARDIOL 2009;77:33-39.

  3. Structure and Functional Studies of the CS Domain of the Essential H/ACA Ribonucleoparticle Assembly Protein SHQ1

    Singh, Mahavir; Gonzales, Fernando A.; Cascio, Duilio; Heckmann, Nathanael; Chanfreau, Guillaume; Feigon, Juli; (UCLA)

    2009-03-16

    H/ACA ribonucleoprotein particles are essential for ribosomal RNA and telomerase RNA processing and metabolism. Shq1p has been identified as an essential eukaryotic H/ACA small nucleolar (sno) ribonucleoparticle (snoRNP) biogenesis and assembly factor. Shq1p is postulated to be involved in the early biogenesis steps of H/ACA snoRNP complexes, and Shq1p depletion leads to a specific decrease in H/ACA small nucleolar RNA levels and to defects in ribosomal RNA processing. Shq1p contains two predicted domains as follows: an N-terminal CS (named after CHORD-containing proteins and SGT1) or HSP20-like domain, and a C-terminal region of high sequence homology called the Shq1 domain. Here we report the crystal structure and functional studies of the Saccharomyces cerevisiae Shq1p CS domain. The structure consists of a compact anti-parallel {beta}-sandwich fold that is composed of two {beta}-sheets containing four and three {beta}-strands, respectively, and a short {alpha}-helix. Deletion studies showed that the CS domain is required for the essential functions of Shq1p. Point mutations in residues Phe-6, Gln-10, and Lys-80 destabilize Shq1p in vivo and induce a temperature-sensitive phenotype with depletion of H/ACA small nucleolar RNAs and defects in rRNA processing. Although CS domains are frequently found in co-chaperones of the Hsp90 molecular chaperone, no interaction was detected between the Shq1p CS domain and yeast Hsp90 in vitro. These results show that the CS domain is essential for Shq1p function in H/ACA snoRNP biogenesis in vivo, possibly in an Hsp90-independent manner.

  4. Doença celíaca é super-representada em pacientes com constipação

    Rolf A. A. Pelleboer

    2012-04-01

    Full Text Available OBJETIVO: Tem sido sugerido que pacientes com constipação sejam triados para doença celíaca. Da mesma forma, recomenda-se a investigação desses pacientes para hipotiroidismo e hipercalcemia. Contudo, nenhuma evidência para essas recomendações está disponível até o momento. Assim, propusemos-nos determinar a prevalência de doença celíaca, hipotiroidismo e hipercalcemia em crianças com constipação. MÉTODOS: Estudo de coorte prospectivo com 370 pacientes consecutivos que preencheram os critérios de Roma III para constipação. Esses pacientes foram encaminhados por um clínico geral a um pediatra devido ao fracasso no tratamento com laxantes. RESULTADOS: A biópsia comprovou doença celíaca em sete desses pacientes. Isso é significativamente mais alto (p < 0,001 do que a prevalência de 1:198 de doença celíaca nos Países Baixos. Dois pacientes tinham tiroidite autoimune. Nenhum paciente tinha hipercalcemia. CONCLUSÕES: Conclui-se que a doença celíaca é significativamente super-representada em pacientes com constipação encaminhados por um clínico geral a um pediatra devido ao fracasso no tratamento com laxantes. Todos esses pacientes devem, portanto, ser triados para doença celíaca.

  5. Muerte súbita cardíaca en comunidades de arroyo naranjo en el periodo 2000-2010

    Ochoa Montes, Luis Alberto

    2013-01-01

    Introducción: La Muerte súbita cardíaca dada su elevada incidencia y el dramatismo en su presentación representa un importante desafío en el siglo XXI. Objetivo: Describir la presentación de la muerte súbita cardíaca en las comunidades de Arroyo Naranjo durante el período 2000-2010. Método: Estudio observacional, descriptivo y transversal. Resultados: Se registraron 10014 muertes naturales, de las cuales 1000 (10,0%) fueron súbitas. Las mayores tasas se evidenciaron en mujeres negras...

  6. Accurate placement of substrate RNA by Gar1 in H/ACA RNA-guided pseudouridylation.

    Wang, Peng; Yang, Lijiang; Gao, Yi Qin; Zhao, Xin Sheng

    2015-09-01

    H/ACA RNA-guided ribonucleoprotein particle (RNP), the most complicated RNA pseudouridylase so far known, uses H/ACA guide RNA for substrate capture and four proteins (Cbf5, Nop10, L7Ae and Gar1) for pseudouridylation. Although it was shown that Gar1 not only facilitates the product release, but also enhances the catalytic activity, the chemical role that Gar1 plays in this complicated machinery is largely unknown. Kinetics measurement on Pyrococcus furiosus RNPs at different temperatures making use of fluorescence anisotropy showed that Gar1 reduces the catalytic barrier through affecting the activation entropy instead of enthalpy. Site-directed mutagenesis combined with molecular dynamics simulations demonstrated that V149 in the thumb loop of Cbf5 is critical in placing the target uridine to the right position toward catalytic D85 of Cbf5. The enzyme elegantly aligns the position of uridine in the catalytic site with the help of Gar1. In addition, conversion of uridine to pseudouridine results in a rigid syn configuration of the target nucleotide in the active site and causes Gar1 to pull out the thumb. Both factors guarantee the efficient release of the product. PMID:26206671

  7. Shifting the open enrollment period for ACA Marketplaces could increase enrollment and improve plan choices.

    Swartz, Katherine; Graves, John A

    2014-07-01

    The next open enrollment period for plans offered in the Affordable Care Act's (ACA's) insurance Marketplaces is set to occur between November 15, 2014, and February 15, 2015--just when many lower-income people are financially stressed by demands of the holiday season. Recent research by experimental psychologists and behavioral economists strongly suggests that when people's decision-making capacity (bandwidth) is stretched thin, either they cannot make decisions or they make poor choices. Using data from nearly a decade of US-based Internet search queries to measure population behavior, we found considerable seasonality in measures of financial stress and in when people seek out information on health insurance plans. A more opportune time for scheduling open enrollment for the ACA Marketplaces may be between February 15 and April 15--weeks when low-income people typically receive income tax refunds and Earned Income Tax Credit payments. Such lump-sum payments could be applied to pay individuals' share of premiums. PMID:24966287

  8. INSUFICIENCIA CARDÍACA CONGESTIVA O COR PULMONALE Congestive heart failure or Cor Pulmonale

    Oscar Ernesto Amarís Peña

    2006-06-01

    Full Text Available La insuficiencia cardíaca es una de las principales causas de muerte cardiovascular y se presenta como consecuencia, en más del 70 por ciento de los casos, de las dos enfermedades cardiovasculares de mayor prevalencia: la hipertensión arterial y la enfermedad coronaria. La disnea y el edema en los miembros inferiores son los dos criterios más usados para el diagnóstico de insuficiencia cardíaca congestiva y estos son, justamente, las principales manifestaciones de los pacientes con Cor Pulmonale. Este documento propone algunos criterios para el diagnóstico diferencial de las dos entidades.Heart failure is one of the most important causes of cardiovascular death, as consequence of arterial hypertension or coronary heart disease. Dyspnea and legs edema are the commonest symptoms of congestive heart failure, but there are important symptoms in Cor Pulmonale, too. This paper propose some distinctive clues to differential diagnosis.

  9. Cellular response to substrate rigidity is governed by either stress or strain.

    Yip, Ai Kia; Iwasaki, Katsuhiko; Ursekar, Chaitanya; Machiyama, Hiroaki; Saxena, Mayur; Chen, Huiling; Harada, Ichiro; Chiam, Keng-Hwee; Sawada, Yasuhiro

    2013-01-01

    Cells sense the rigidity of their substrate; however, little is known about the physical variables that determine their response to this rigidity. Here, we report traction stress measurements carried out using fibroblasts on polyacrylamide gels with Young's moduli ranging from 6 to 110 kPa. We prepared the substrates by employing a modified method that involves N-acryloyl-6-aminocaproic acid (ACA). ACA allows for covalent binding between proteins and elastomers and thus introduces a more stable immobilization of collagen onto the substrate when compared to the conventional method of using sulfo-succinimidyl-6-(4-azido-2-nitrophenyl-amino) hexanoate (sulfo-SANPAH). Cells remove extracellular matrix proteins off the surface of gels coated using sulfo-SANPAH, which corresponds to lower values of traction stress and substrate deformation compared to gels coated using ACA. On soft ACA gels (Young's modulus 20 kPa), traction stress plateaus at a limiting value and the substrate deformation decreases with increasing substrate rigidity. Sustained substrate strain on soft substrates and sustained traction stress on stiff substrates suggest these may be factors governing cellular responses to substrate rigidity. PMID:23332055

  10. Tratamento otimizado e redução da frequência cardíaca na insuficiência cardíaca crônica

    Irineu Blanco Moreno

    2013-11-01

    Full Text Available FUNDAMENTO: A Insuficiência Cardíaca (IC é uma síndrome que cursa com má evolução nas formas avançadas. O bloqueio neuro-hormonal modifica essa história natural; no entanto, ele com frequência é subotimizado. OBJETIVO: Neste estudo procuramos verificar em qual percentual médicos cardiologistas habituados no tratamento da IC conseguem prescrever as doses-alvo dos medicamentos de comprovada eficácia. MÉTODOS: Foram selecionados consecutivamente 104 pacientes ambulatoriais com disfunção sistólica, todos sob tratamento estabilizado. Avaliaram-se dados demográficos e o tratamento verificando-se as doses atingidas. Os achados são apresentados em percentual e fizeram-se correlações entre as diferentes variáveis. RESULTADOS: A idade média dos pac. foi de 64,1 ± 14,2 anos, com PAS 115,4 ± 15,3 mmHg, FC de 67,8 ± 9,4 bpm, peso 76,0 ± 17,0 kg e em ritmo sinusal (90,4%. Quanto ao tratamento, 93,3% estavam recebendo um bloqueador do SRA (52,9% IECA, todos recebiam betabloqueador (BB, sendo o carvedilol o mais prescrito (92,3%. Quanto às doses: 97,1% dos que recebiam um BRA estavam com dose abaixo da ideal; os que recebiam IECA 52,7% receberam dose otimizada. Quanto ao BB, em 76,0% foi possível prescrever as doses alvos. Nesse grupo de pac. a maioria com dose alvo do BB, pode-se observar que 36,5% apresentavam frequência cardíaca igual ou maior que 70 bpm em ritmo sinusal. CONCLUSÕES: Médicos cardiologistas habituados no tratamento da IC conseguem prescrever as doses-alvo de inibidores da ECA e BB para a maioria dos pac. Mesmo recebendo as doses preconizadas, cerca de um terço dos pac. persiste com FC acima de 70 bpm e deveria ter seu tratamento otimizado.

  11. Influência da vitamina C na modulação autonômica cardíaca no repouso e durante o exercício isométrico em crianças obesas The influence of vitamin C on cardiac autonomic modulation at rest and during isometric exercise in obese children

    Fabio Alexandre dos Santos Lira

    2012-09-01

    Full Text Available OBJETIVOS: comparar, entre obesos e eutróficos, os parâmetros de modulação autonômica cardíaca e analisar o efeito da suplementação da vitamina C na modulação autonômica cardíaca em crianças obesas, no repouso e durante o exercício isométrico respectivamente. MÉTODOS: participaram oito crianças eutróficas (IMC = 18 ± 1Kg/cm² e 21 obesas (IMC = 29 ± 1Kg/cm², com idade entre 8 e 11 anos, ambos os gêneros, distribuídas em dois grupos: suplementadas com 500 mg de vitamina C (n=11, e placebo (n=10, durante 45 dias. Modulação autonômica cardíaca foi avaliada por análise espectral da variabilidade da frequência cardíaca em repouso e durante o exercício isométrico. RESULTADOS: crianças obesas, no repouso e durante o exercício isométrico, apresentaram uma maior ativação simpática cardíaca e uma menor atividade vagal. Quando se comparou os componentes espectrais de baixa e alta frequência entre os grupos avaliados, observaram-se diferenças significativas. Após suplementação com vitamina C, os componentes espectrais foram similares àqueles observados nas crianças eutróficas, tanto no repouso como durante o exercício isométrico. CONCLUSÕES: crianças obesas apresentam uma maior atividade simpática e menor atividade vagal no repouso e durante o exercício isométrico quando comparada as crianças eutróficas. Como também, a suplementação oral com vitamina C, em altas doses, pode restaurar a disfunção autonômica cardíaca em crianças obesas.OBJECTIVES: to draw a comparison between obese and eutrophic children regarding cardiac autonomic modulation and to investigate the effect of vitamin C supplements on cardiac autonomic modulation in obese children, at rest and during isometric exercise. METHODS: the study covered eight eutrophic (IMC= 18 ± 1Kg/cm² and 21 obese (IMC = 29 ± 1Kg/cm² children aged between 8 and 11 years of both sexes, distributed into two groups: one receiving a 500 mg vitamin C

  12. Prevention under the Affordable Care Act (ACA: Has the ACA Overpromised and under Delivered?; Comment on “Interrelation of Preventive Care Benefits and Shared Costs under the Affordable Care Act (ACA”

    Carol Molinari

    2014-08-01

    Full Text Available This policy brief discusses preventive care benefits and cost-sharing included in health insurance provisions of the Affordable Care Act (ACA legislation and highlights some consequences to Americans and the country in terms of healthcare costs and value.

  13. Insuficiência cardíaca: estratégias usadas por idosos na busca por qualidade de vida

    Analyane Conceição Silva dos Santos

    2011-10-01

    Full Text Available Estudo descritivo com abordagem qualitativa cujos objetivos foram identificar as repercussões da insuficiência cardíaca na qualidade de vida dos idosos; descrever as estratégias utilizadas no enfrentamento destas repercussões e conhecer as percepções acerca dos cuidados de enfermagem. Foram realizadas entrevistas semiestruturadas com dez idosos com insuficiência cardíaca em um hospital militar do Rio de Janeiro-RJ. Identificou-se que a insuficiência cardíaca gera repercussões emocionais, físicas e financeiras na vida dos idosos, ocasionando impacto na qualidade de vida. Dentre as estratégias criadas pelos idosos, verificou-se o enfrentamento paliativo e o enfrentamento emocional. Os cuidados de enfermagem evidenciados foram orientação, carinho, zelo e dedicação. Cuidar do idoso com insuficiência cardíaca implica em avaliar as repercussões na capacidade funcional e autonomia dos anciãos, exigindo habilidades e competências do enfermeiro para identificar suas especificidades na perspectiva de um cuidado integral que contribua para a qualidade de vida dos mesmos.

  14. Political Ideology and Its Relationship to Perceptions of Social Justice Advocacy among Members of the American Counseling Association (ACA)

    Steele, Janee Marie

    2010-01-01

    Social justice has become an increasingly controversial topic among members of the American Counseling Association (ACA). Specifically, concerns have been raised over what is perceived to be: (a) the liberal political agenda of social justice advocates, (b) the marginalization of conservative counselors, and (c) the inappropriate use of ACA…

  15. Use of aminocaproic acid (ACA in extra-amniotic MTP in patients on anti-coagulant therapy.

    Kale P

    1992-10-01

    Full Text Available A case of rheumatic heart disease (RHD with prosthetic mitral valve endocarditis receiving anticoagulation with heparin, underwent medical termination of pregnancy in a second trimester. The following report entails the use of aminocaproic acid (ACA in preventing excessive bleeding during and after the procedure, while the patient continued to receive anticoagulant therapy.

  16. Variabilidade da frequência cardíaca em neonatos prematuros e de termo

    Fabio Augusto Selig

    2011-06-01

    Full Text Available FUNDAMENTO: Várias publicações têm demonstrado a importância do sistema nervoso autônomo por meio dos componentes simpático e parassimpático na gerência da interação entre as diferentes partes do organismo humano. Esses estudos aplicaram técnicas lineares e não lineares (Teoria do Caos de avaliação em diferentes situações, doenças e faixas etárias, tendo como ferramenta a variabilidade da frequência cardíaca (VFC. OBJETIVO: Aplicar os conhecimentos das dinâmicas linear e não linear na avaliação de neonatos prematuros (NPT, analisando sua VFC e comparando com neonatos de termo (NT saudáveis. MÉTODOS: Quarenta e oito neonatos prematuros com diferentes idades gestacionais tiveram seus batimentos cardíacos captados com auxílio do equipamento Polar Advanced S810i e sua VFC obtida pelo registro dos intervalos RR. A VFC foi analisada nos domínios do tempo (SDNN, RMSSD, SD1/SD2, da frequência (VLF, LF, HF e a relação LF/HF e do caos (TAU e sua normalização [TAU(n], Expoente de Lyapunov e Entropia. Os NPT foram comparados com um grupo de 78 NT saudáveis e sem intercorrências perinatais com auxílio do teste não paramétrico de Kruskal-Wallis. RESULTADOS: Detectou-se diferença estatisticamente significante entre os grupos para todas as variáveis estudadas, tanto no domínio do tempo como nos da frequência e do caos. CONCLUSÃO: Neonatos prematuros exibem comportamento menos complexo da variabilidade da frequência cardíaca que neonatos de termo, fato comprovado nos domínios do tempo, da frequência e do caos. O estudo da variabilidade cardíaca nesse grupo pode ser considerado uma ferramenta a mais na avaliação da maturação autonômica e, consequentemente, da progressão para eutrofia.

  17. Taking iron supplements

    ... medlineplus.gov/ency/article/007478.htm Taking iron supplements To use the sharing features on this page, ... levels. You may also need to take iron supplements as well to rebuild iron stores in your ...

  18. Dietary Supplements for Toddlers

    ... Listen Español Text Size Email Print Share Dietary Supplements for Toddlers Page Content Article Body If you ... a diet recommended for children), she may need supplements of vitamins B12 and D as well as ...

  19. Emerging Supplements in Sports

    Mason, Bryan C.; Lavallee, Mark E.

    2012-01-01

    Context: Nutritional supplements advertised as ergogenic are commonly used by athletes at all levels. Health care professionals have an opportunity and responsibility to counsel athletes concerning the safety and efficacy of supplements on the market. Evidence Acquisition: An Internet search of common fitness and bodybuilding sites was performed to identify supplement promotions. A search of MEDLINE (2000–August, 2011) was performed using the most commonly identified supplements, including gl...

  20. Effects of Supplemental Dietary Phytase and 25-Hydroxycholecalciferol on the Digestive and Reproductive Organ Characteristics of Commercial Layers Inoculated Before or at the Onset of Lay with the F-Strain of Mycoplasma galli

    In 3 trials, the effects of dietary supple mentation with phytase (PHY) and 25-hydroxycholecalciferol (25-D3) on the digestive and reproductive organ characteristics of commercial layers that were inoculated pre-lay (12 wk of age) or at the onset of lay (22 wk of age) with F-strain Mycoplasma gallis...

  1. Parada cardíaca inesperada durante colecistectomia: relato de caso

    Croitor Lorena Brito da Justa

    2002-01-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A parada cardíaca per-operatória é um evento grave, e sua incidência em nosso serviço é de 31:10.000 anestesias. O objetivo deste relato é apresentar um caso de parada cardíaca durante anestesia geral em uma paciente submetida a colecistectomia. RELATO DO CASO: Paciente feminina, 16 anos, 62 kg, estado físico ASA I, submetida à colecistectomia por via aberta. Midazolam (15 mg por via oral foi a medicação pré-anestésica. Foi realizadas indução anestésica com sufentanil (50 µg, propofol (150 mg e atracúrio (30 mg. A anestesia foi mantida com isoflurano e N2O. Após trinta minutos de cirurgia ocorreu bradicardia sinusal revertida com atropina (0,5 mg. Vinte minutos depois, ocorreu outra bradicardia com bloqueio átrio-ventricular de 3º grau evoluindo rapidamente para parada cardíaca (PCR em assistolia, apesar da administração de atropina (1 mg. As manobras de reanimação foram iniciadas imediatamente, juntamente com a administração de adrenalina (1 mg, com retorno dos batimentos cardíacos espontâneos após aproximadamente cinco minutos da PCR. A cirurgia foi concluída e a paciente manteve-se estável hemodinami- camente. A paciente foi extubada duas horas após o término da cirurgia apresentando-se sonolenta, não contactante, com bom padrão ventilatório e hemodinâmico. Após doze horas de observação na unidade de terapia intensiva (UTI a paciente apresentava-se agitada e desconexa. Vinte e quatro horas após a PCR a paciente recebeu alta da UTI consciente, orientada, sem queixas e sem déficit neurológico. Recebeu alta hospitalar no 4º dia do pós-operatório. CONCLUSÕES: Diversos fatores podem contribuir para a ocorrência de disritmias e parada cardíaca no per-operatório, destacando-se a estimulação vagal secundária às manobras cirúrgicas. O diagnóstico precoce e o rápido início das manobras de reanimação são de fundamental importância para a boa evolução neurol

  2. Manifestações orais da Doença Celíaca em Odontopediatria

    Sousa, Joana Luísa Ribeiro Ferreira Pereira de

    2012-01-01

    Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária A doença celíaca (DC) é uma enteropatia comum, caraterizada pela permanente intolerância ao glúten. Tem sido descrito por vários autores a importância das manifestações orais provocadas por esta doença para um diagnóstico precoce, sendo as mais comuns, defeitos de esmalte, baixa incidência de cárie e ulcerações aftosas recorrentes. ...

  3. Cansaço do reanimador durante a massagem cardíaca externa

    Preto, Leonel; Novo, André

    2013-01-01

    As recomendações em reanimação têm vindo a dar importância à massagem cardíaca externa realizada com qualidade. O esforço do reanimador tem vindo a ser alvo de alguns estudos que têm vindo a concluir que o cansaço afeta negativamente a qualidade das compressões torácicas. A dosagem sanguínea do lactato é uma forma prática e muito objetiva de se obter uma avaliação do metabolismo do lactato e do limiar anaeróbio e, portanto, um indicador preciso de esforço e fadiga. O objetivo deste trabalho f...

  4. Grupo de pacientes de cirurgia cardíaca: relato de experiência

    Elisa Helena Kuhn

    1986-09-01

    Full Text Available Neste trabalho relata-se uma experiência de grupo com pacientes de cirurgia cardíaca. A atividade realiza-se no INSTITUTO DE CARDIOLOGIA DO RIO GRANDE DO SUL e tem por objetivo proporcionar aos pacientes a oportunidade de verbalizarem suas ansiedades e conversarem sobre suas experiências relacionadas com a cirurgia e anestesia. Os grupos reúnem-se duas vezes por semana sendo constituídos por pacientes adultos em pré e pós-operatório imediato. A equipe de saúde é composta por enfermeiros, psicólogo, anestesista, cardiologistas e fisioterapeutas e sua atuação é no sentido de auxiliar na compreensão dos procedimentos aos quais o paciente vai se submeter, desfazendo fantasias distorcidas da realidade.

  5. Caquexia associada à insuficiência cardíaca Heart failure-induced cachexia

    Marina Politi Okoshi

    2013-05-01

    Full Text Available Pacientes com insuficiência cardíaca frequentemente desenvolvem estado de caquexia, que constitui fator independente de redução da sobrevida. Caquexia pode ser diagnosticada quando ocorre perda de peso corporal maior que 6% do peso habitual, na ausência de outras doenças. Embora sua fisiopatologia não esteja completamente esclarecida, vários fatores parecem estar envolvidos, como diminuição da ingestão alimentar, anormalidades do trato gastrointestinal, ativação imunológica e neuro-hormonal e alteração da relação entre processos anabólicos e catabólicos. Como não há terapia específica para a caquexia associada à insuficiência cardíaca, o tratamento baseia-se no suporte nutricional, bloqueio neuro-hormonal, controle do edema e anemia e exercícios físicos. Fármacos com propriedades imunomodulatórias e anabólicas encontram-se em investigação clínica e experimental.Heart failure patients often develop cachexia, which is an independent factor for survival reduction. Cachexia can be diagnosed when there is loss of more than 6% of the body weight, in the absence of other diseases. Even though its pathophysiology has not yet been completely clarified, various factors seem to be involved, such as reduction in food consumption, gastrointestinal tract abnormalities, immunologic and neuro-hormonal activarion and changes in the relationship between anabolic and catabolic processes. Since there is not specific therapy for heart failure-induced cachexia, management is based on nutritional support, neuro-hormonal blockade, control of edema and anemia and exercise. Drugs with anabolic and immunomodulating properties are being evaluated and clinical and non-clinical trials.

  6. Psiscan: a computational approach to identify H/ACA-like and AGA-like non-coding RNA in trypanosomatid genomes

    Ziporen Yaara

    2008-11-01

    Full Text Available Abstract Background Detection of non coding RNA (ncRNA molecules is a major bioinformatics challenge. This challenge is particularly difficult when attempting to detect H/ACA molecules which are involved in converting uridine to pseudouridine on rRNA in trypanosomes, because these organisms have unique H/ACA molecules (termed H/ACA-like that lack several of the features that characterize H/ACA molecules in most other organisms. Results We present here a computational tool called Psiscan, which was designed to detect H/ACA-like molecules in trypanosomes. We started by analyzing known H/ACA-like molecules and characterized their crucial elements both computationally and experimentally. Next, we set up constraints based on this analysis and additional phylogenic and functional data to rapidly scan three trypanosome genomes (T. brucei, T. cruzi and L. major for sequences that observe these constraints and are conserved among the species. In the next step, we used minimal energy calculation to select the molecules that are predicted to fold into a lowest energy structure that is consistent with the constraints. In the final computational step, we used a Support Vector Machine that was trained on known H/ACA-like molecules as positive examples and on negative examples of molecules that were identified by the computational analyses but were shown experimentally not to be H/ACA-like molecules. The leading candidate molecules predicted by the SVM model were then subjected to experimental validation. Conclusion The experimental validation showed 11 molecules to be expressed (4 out of 25 in the intermediate stage and 7 out of 19 in the final validation after the machine learning stage. Five of these 11 molecules were further shown to be bona fide H/ACA-like molecules. As snoRNA in trypanosomes are organized in clusters, the new H/ACA-like molecules could be used as starting points to manually search for additional molecules in their neighbourhood. All

  7. Respuesta cardíaca en jugadores de fútbol de tercera división durante partidos oficiales y entrenamientos

    Parra Rojas, Nicolás

    2016-01-01

    Justificación. La frecuencia cardíaca es una de las variables más utilizadas para el registro del compromiso fisiológico de los deportistas. En este sentido, en nuestra investigación se intenta determinar, partiendo de la respuesta cardíaca de los futbolistas, los niveles de intensidad alcanzados por éstos en función del tipo de actividad (entrenamiento o competición) y en función del puesto específico ocupado en el terreno de juego. Objetivos. Analizar la respuesta cardíaca en futbolistas...

  8. Comportamento dos quimiorreflexos central e periférico na insuficiência cardíaca

    Guilherme Veiga Guimarães

    2011-02-01

    Full Text Available A síndrome da insuficiência cardíaca (IC pode ser definida como via final de qualquer forma de doença cardíaca. Os reflexos cardiovasculares simpatoinibitórios como o reflexo arterial barorreceptor estão significativamente suprimidos na IC. Pacientes com IC apresentam maior ventilação para determinada carga de trabalho quando comparados a indivíduos normais. Esse fato gera baixa eficiência ventilatória e relaciona-se com maior ventilação relativa à produção de gás carbônico, que é um preditor de mau prognóstico, além de ser um fator limitante ao exercício. Há evidências de que o desequilíbrio autonômico contribua para a patogênese e a progressão da insuficiência cardíaca. Os quimiorreflexos são os principais mecanismos de controle e regulação das respostas ventilatórias às mudanças de concentração do oxigênio e gás carbônico arterial. A ativação do quimiorreflexo causa aumento da atividade simpática, frequência cardíaca, pressão arterial e volume minuto. No entanto, o aumento do volume minuto e da pressão arterial, pelo feedback negativo provocam inibição da resposta simpática à ativação do quimiorreflexo. Apesar das alterações funcionais dos reflexos, seu comportamento em condições normais e patológicas, especialmente sua contribuição para o estado simpatoexcitatório encontrado na IC, não tem sido amplamente estudado. Dessa forma, esta revisão tem por objetivo integrar os conhecimentos a respeito dos quimiorreflexos central e periférico na síndrome da insuficiência cardíaca, bem como esclarecer a influência da terapêutica medicamentosa da insuficiência cardíaca nos quimiorreflexos.

  9. Fase crônica cardíaca fibrosante da Tripanossomíase cruzi experimental no cão

    Marta de Lana

    1988-09-01

    Full Text Available Os autores documentam a cardiopatia difusa fibrosante, com todos os sintomas clínicos e dados de autópsia pertinentes à insuficiência cardíaca congestiva, em um dos 21 cães infectados com a cepa Colombiana (cinco morreram na fase aguda e quatro continuam vivos e cinco, dos 13 infectados com a cepa Berenice-78 (oito morreram na fase aguda, num período de oito anos de observação. Em vista destes resultados, os autores sugerem que o cão possa vir a ser um modelo experimental, adequado para o estudo da história natural da doença de Chagas, preenchendo os requisitos estabelecidos pelo Comitê Assessor de Doença de Chagas do Programa Especial de Pesquisa e Treinamento em Doenças Tropicais da Organização Mundial de Saúde.The authors found the fibrosing chronic chagasic cardiopathy with congestive heartfailure in one out of the 21 dogs infected with the Colombian strain (five died in acutephase andfour are alivefive out of the 13 animais infected with the Berenice-78 strain eight died in acute phase were observed until eight years of infection with T. cruzi. In view of these results, the author suggest that the dog could be a suitable experimental model for the study of the natural history of Chagas' disease. The dog conforms with the requisites of the World Health Organization (WHO Steering Committee of Chagas' disease of the Programmefor Research Training in Tropical Diseases.

  10. Polimorfismo G894T da óxido nítrico-sintetase endotelial e o prognóstico na insuficiência cardíaca

    2013-01-01

    FUNDAMENTO: Estudos prévios avaliaram o papel do polimorfismo genético da enzima óxido nítrico-sintetase endotelial sobre o prognóstico na insuficiência cardíaca. Entretanto, faltam estudos relacionando o G894T e a insuficiência cardíaca na população brasileira. OBJETIVO: Avaliar a associação do G894T com o prognóstico de amostra de pacientes brasileiros com insuficiência cardíaca. MÉTODOS: Coorte com 145 pacientes com insuficiência cardíaca sistólica, num segmento de 40 meses (média = 22 mes...

  11. Detection and Identification of Probiotic Lactobacillus plantarum Strains by Multiplex PCR Using RAPD-Derived Primers

    Alex Galanis

    2015-10-01

    Full Text Available Lactobacillus plantarum 2035 and Lactobacillus plantarum ACA-DC 2640 are two lactic acid bacteria (LAB strains that have been isolated from Feta cheese. Both display significant potential for the production of novel probiotic food products. The aim of the present study was the development of an accurate and efficient method for the molecular detection and identification of the above strains in a single reaction. A multiplex PCR assay was designed for each strain, based on specific primers derived from Random Amplified Polymorphic DNA (RAPD Sequenced Characterized Amplified Region (SCAR analysis. The specificity of the assay was tested with a total of 23 different LAB strains, for L. plantarum 2035 and L. plantarum ACA-DC 2640. The multiplex PCR assay was also successfully applied for the detection of the above cultures in yogurt samples prepared in our lab. The proposed methodology may be applied for monitoring the presence of these strains in food products, thus evaluating their probiotic character. Moreover, our strategy may be adapted for other novel LAB strains with probiotic potential, thus providing a powerful tool for molecular discrimination that could be invaluable to the food industry.

  12. Detection and Identification of Probiotic Lactobacillus plantarum Strains by Multiplex PCR Using RAPD-Derived Primers

    Galanis, Alex; Kourkoutas, Yiannis; Tassou, Chrysoula C.; Chorianopoulos, Nikos

    2015-01-01

    Lactobacillus plantarum 2035 and Lactobacillus plantarum ACA-DC 2640 are two lactic acid bacteria (LAB) strains that have been isolated from Feta cheese. Both display significant potential for the production of novel probiotic food products. The aim of the present study was the development of an accurate and efficient method for the molecular detection and identification of the above strains in a single reaction. A multiplex PCR assay was designed for each strain, based on specific primers derived from Random Amplified Polymorphic DNA (RAPD) Sequenced Characterized Amplified Region (SCAR) analysis. The specificity of the assay was tested with a total of 23 different LAB strains, for L. plantarum 2035 and L. plantarum ACA-DC 2640. The multiplex PCR assay was also successfully applied for the detection of the above cultures in yogurt samples prepared in our lab. The proposed methodology may be applied for monitoring the presence of these strains in food products, thus evaluating their probiotic character. Moreover, our strategy may be adapted for other novel LAB strains with probiotic potential, thus providing a powerful tool for molecular discrimination that could be invaluable to the food industry. PMID:26506345

  13. [Peptide mapping of the major proteins in 2 strains of influenza virus].

    Savich, I M; Gerasimova, L M; Mertvetsov, N P

    1985-01-01

    The protein composition of two influenza A virus strains from different serological groups was studied. For preliminary separation of envelope and core proteins the virus was treated with nonionic detergent Triton X-100 solution followed by chromatography in ultragel AcA 34. After their separation by disk electrophoresis and treatment with trypsin they were labeled with tritium and peptide analysis was carried out. Differences in peptide maps between the appropriate light and heavy chains of hemagglutinins of the strains under study were demonstrated. Differences in the composition of nucleoprotein and matrix protein were insignificant. PMID:3922120

  14. Treinamento físico na distrofia muscular de becker associada à insuficiência cardíaca

    Jean Marcelo Roque

    2011-12-01

    Full Text Available A distrofia muscular de Becker (DMB integra as distrofinopatias que ocorrem devido a mutações genéticas que expressam a proteína distrofina no cromossomo X. O início dos sintomas neuromusculares normalmente precede o comprometimento da função cardíaca, podendo acontecer inversamente pela insuficiência cardíaca (IC. O treinamento físico é bem estabelecido na IC, porém, quando associada à DMB, é controverso e sem fundamento científico. Apresentamos o caso de um paciente com DMB associada à IC em fila de transplante cardíaco submetido a um programa de treinamento físico.

  15. Realidad de la cirugía cardíaca en la República Argentina. Registro CONAREC XVI

    Diego M. Lowenstein Haber; Fernando M. Guardiani; Pablo Pieroni; Lisandro Pfister; Laura Carrizo; Esteban D. Villegas; María F. Renedo; Federico J. Landeta; Jorge Thierer

    2010-01-01

    RESUMENIntroducciónLos dos grandes registros multicéntricos de cirugía cardíaca realizados en la Argentina,CONAREC y ESMUCICA, datan de más de 10 años. Considerando los avances médicosy quirúrgicos de la última década, surgió la necesidad de realizar un nuevo registronacional, prospectivo y multicéntrico para conocer las características, la evolución, lascomplicaciones y los predictores de mortalidad de los pacientes sometidos a cirugía cardíaca.ObjetivosConocer el perfil epidemiológico, la m...

  16. Mediastinite pós-esternotomia longitudinal para cirurgia cardíaca: 10 anos de análise

    Valdir Cesarino de Souza; André Ney Menezes Freire; José Tavares-Neto

    2002-01-01

    INTRODUÇÃO: mediastinites pós-esternotomia para cirurgia cardíaca não são freqüentes (0,2% a 5,0%), porém, quando surgem, se tornam potencialmente graves. Mesmo com o diagnóstico e tratamento precoces, o prognóstico não é bom, sobretudo se houver sepse e outros agravos à saúde associados. OBJETIVO: rever a casuística de casos de mediastinite. MÉTODO: foram analisados os prontuários de 2.272 pacientes submetidos à cirurgia cardíaca entre 1991 e 2000. Todas as operações foram realizadas através...

  17. 一种新的混合并行蚁群算法研究应用%Research on a new hybrid parallel ACA

    王磊

    2012-01-01

    提出了一种新的混合并行蚁群算法,在单机多核机及多核集群机下分别实现了MPI并行蚁群算法及MPI+ TBB并行蚁群算法,应用于真实路网车辆路径问题(Vehicle Routing Problem,VRP),对两者进行了实验对比,实验结果表明MPI并行蚁群算法具有较高的加速比,和问题规模关系不大,刚开始呈现线性加速比.较MPI并行蚁群算法,MPI+ TBB混合并行蚁群算法具有更好的可扩展性,在进程数较多时仍具有较高的加速比.%A new hybrid parallel ant colony algorithm (ACA) is presented, respectively construct MPI parallel ACA and MPI + TBB parallel ACA in the multi-core single machine and multi-core clusters to apply to the real road network for vehicle routing problem ( VRP). The experimental results show that MPI based parallel ACA make higher speedup , have nothing to do with problem size, and show linear speedup at the beginning. MPI + TBB based parallel hybrid parallel ACA has better scalability and a more high speedup than the MPI based parallel ACA in the more processes.

  18. Seguridad del paciente en el postoperatorio de cirugía cardíaca en UCI

    Álvarez Menéndez, Katia

    2013-01-01

    Describir las medidas de seguridad del paciente que se adoptan en el postoperatorio de cirugía cardíaca en UCI y comprobar que dichas medidas de seguridad del paciente son efectivas y proporcionan beneficios a los pacientes. Para ello se describen todos los protocolos y dispositivos específicos y se comparan los resultados obtenidos en cuanto a los protocolos de Neumonía Zero y Bacteriemia Zero.

  19. Enzymatic activity and immunoreactivity of Aca s 4, an alpha-amylase allergen from the storage mite Acarus siro

    Pytelková, Jana; Lepšík, Martin; Šanda, Miloslav; Talacko, Pavel; Marešová, Lucie; Mareš, Michael

    2012-01-01

    Roč. 13, č. 3 (2012), s. 1-8. ISSN 1471-2091 R&D Projects: GA ČR GP525/09/P600 Institutional research plan: CEZ:AV0Z40550506 Keywords : Aca s 4 * Acarus siro * alpha- amylases Subject RIV: CE - Biochemistry Impact factor: 1.776, year: 2012 http://www.biomedcentral.com/1471-2091/13/3

  20. The Impact of Market Size and Composition on Health Insurance Premiums: Evidence from the First Year of the ACA

    Michael J. Dickstein; Mark Duggan; Joseph Orsini; Pietro Tebaldi

    2015-01-01

    Under the Affordable Care Act, individual states have discretion in how they define coverage regions, within which insurers must charge the same premium to buyers of the same age, family structure, and smoking status. We exploit variation in these definitions to investigate whether the size of the coverage region affects outcomes in the ACA marketplaces. We find large consequences for small and rural markets. When states combine small counties with neighboring urban areas into a single region...

  1. Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies.

    Vogan, Jacob M; Zhang, Xiaozhu; Youmans, Daniel T; Regalado, Samuel G; Johnson, Joshua Z; Hockemeyer, Dirk; Collins, Kathleen

    2016-01-01

    We dissected the importance of human telomerase biogenesis and trafficking pathways for telomere maintenance. Biological stability of human telomerase RNA (hTR) relies on H/ACA proteins, but other eukaryotes use other RNP assembly pathways. To investigate additional rationale for human telomerase assembly as H/ACA RNP, we developed a minimized cellular hTR. Remarkably, with only binding sites for telomerase reverse transcriptase (TERT), minimized hTR assembled biologically active enzyme. TERT overexpression was required for cellular interaction with minimized hTR, indicating that H/ACA RNP assembly enhances endogenous hTR-TERT interaction. Telomere maintenance by minimized telomerase was unaffected by the elimination of the telomerase holoenzyme Cajal body chaperone TCAB1 or the Cajal body scaffold protein Coilin. Surprisingly, wild-type hTR also maintained and elongated telomeres in TCAB1 or Coilin knockout cells, with distinct changes in telomerase action. Overall, we elucidate trafficking requirements for telomerase biogenesis and function and expand mechanisms by which altered telomere maintenance engenders human disease. PMID:27525486

  2. Identification and evolutionary implication of four novel box H/ACA snoRNAs from Giardia lamblia

    LUO Jun; ZHOU Hui; CHEN Chongjian; LI Yan; CHEN Yueqin; QU Lianghu

    2006-01-01

    From a specialized cDNA library, four novel box H/ACA snoRNAs, named GLsR22,GLsR23, GLsR24 and GLsR25, were identified from the primitive eukaryote, Giardia lamblia. Bioinformatics analyses indicated that all of them can be potentially folded into double hairpins, the typical secondary structures of box H/ACA snoRNAs. GLsR24 and GLsR25 are predicted to guide the site-specific pseudouridylation at U1753 and U2396 on 23S rRNA,respectively, while GLsR22 and GLsR23 belong to the family of "orphan" snoRNAs. All of the four novel snoRNAs are encoded by single copy genes and located in small intergenic regions. Interestingly,compared with the counterparts previously reported in Archaea and other unicellular protozoan, the box H/ACA snoRNAs identified from G. lamblia have unique structural features, implying that snoRNAs evolved from prokaryotes to eukaryotes in different ways.

  3. Muerte súbita por conmoción cardíaca (Commotio cordis asociada a miocardio no compactado

    Analía Aquieri

    2011-12-01

    Full Text Available El miocardio no compactado es una rara miocardiopatía congénita caracterizada por la presencia de múltiples y prominentes trabeculaciones profundas en la pared ventricular que definen hendiduras comunicantes con el compartimiento ventricular principal. Es una entidad de baja incidencia y prevalencia que se diagnostica mediante estudios de imágenes como el ecocardiograma Doppler (ED, la tomografía computarizada multicorte (TCM y la resonancia magnética cardíaca (RMC. Puede ser asintomática o manifestarse mediante arritmias, insuficiencia cardíaca o eventos tromboembólicos. Se presenta el caso de un hombre de 33 años, asintomático, que durante la práctica deportiva sufre una conmoción cardíaca (commotio cordis que le produce un paro cardiorrespiratorio. El electrocardiograma mostró un ritmo de aleteo ventricular que requirió cardiodesfibrilación eléctrica. En un ED efectuado inicialmente no se observaron anormalidades significativas, pero otro ED, una TCM y una RMN obtenidos luego del alta, certificaron el hallazgo de miocardio no compactado aislado, descartando coronariopatía. Recibió tratamiento beta bloqueante y antiagregante y se discutió la colocación del cardiodesfibrilador implantable. Se plantea la fisiopatología de la asociación de estas dos infrecuentes y potencialmente letales afecciones.

  4. FERMENTATION EFFICIENCY OF YEAST ISOLATES AND THE EFECT OF NUTRIENT SUPPLEMENTS

    HELEN SOIBAM1, AYAM VICTOR SINGH2, IVI CHAKRABORTY3

    2014-12-01

    Full Text Available ABSTRACT: Wine is one of the end products of fermentation of respiratory substrates, while, yeast is one of the principal fermenting microorganisms. Changes in the substrate composition and yeast strains could vary in the quality of the wine. Two yeast isolates (Y4 and Y7 from date palm juice and standard yeast “Y33”,an isolate of Saccharomyces cerevisiae (MTCC-170 from Institute of MicrobiAl Technology, IMTECH, Chandigarh where used for studying the comparative fermentation of Molasses without nutrient supplementation, and separately with nutrient supplementation by KH2PO4 and NaNO3 @ 1g/l. Though, with nutrient supplement KH2PO4, Y33 yields higher alcohol%, both Y4 and Y7 strains produce wine with better efficiency and acceptability without the nutrient supplements unlike Y33 strains. All the three strains impart better flavour and colour in the medium without nutrient supplement in terms of hedonic scale. Further, Y4 yields higher alcohol than Y7 and Y33. Therefore, palm juice yeast isolates particularly, Y4 strains show the highest overall fermentation efficiency and acceptability among the three yeasts isolates, moreover, since its highest efficiency occurs in the absence of nutrient supplementation, unlike the standard strain, it can be recommendedas a better substitute of the standard Y33 strains. KEY WORDS: Fermentation, Yeast,  Nutrient supplements.

  5. Os efeitos da trimetazidina na variabilidade da frequência cardíaca (VFC em pacientes com insuficiência cardíaca Los efectos de la trimetazidina en la variabilidad de la frecuencia cardíaca (VFC en pacientes con insuficiencia cardíaca The effects of trimetazidine on heart rate variability in patients with heart failure

    Yilmaz Gunes

    2009-08-01

    Full Text Available FUNDAMENTO: Tem sido demonstrado que diminuições na variabilidade da frequência cardíaca (VFC estão relacionadas com o prognóstico na insuficiência cardíaca (IC. A administração crônica de trimetazidina, além da terapia convencional, tem melhorado a classe funcional e a função ventricular esquerda de pacientes com IC. OBJETIVO: Avaliar os efeitos da trimetazidina na VFC em pacientes com IC de origem isquêmica, recebendo tratamento otimizado. MÉTODOS: Trimetazidina 20 mg 3 vezes/dia foi adicionada à terapia de 30 pacientes com IC tratados com inibidores da enzima conversora de angiotensinogênio ou bloqueadores do receptor da angiotensina, carvedilol, espironolactona, digital e furosemida. A etiologia da IC era doença arterial coronariana em todos os pacientes. Os pacientes foram avaliados através de ecocardiografia e análise da VFC de 24-horas antes e 3 meses depois da adição de trimetazidina. RESULTADOS: A fração de ejeção ventricular esquerda (FEVE média aumentou significantemente após a adição da trimetazidina (33,5±5,1% para 42,5±5,8%, pFUNDAMENTO: Se ha demostrado que disminuciones en la variabilidad de la frecuencia cardíaca (VFC están relacionadas con el pronóstico en la insuficiencia cardíaca (IC. La administración crónica de trimetazidina, además de la terapia convencional, ha mejorado la clase funcional y la función ventricular izquierda de pacientes con IC. OBJETIVO: Evaluar los efectos de la trimetazidina en la VFC en pacientes con IC de origen isquémico, recibiendo tratamiento optimizado. MÉTODOS: Se agregó trimetazidina 20 mg 3 veces/día a la terapia de 30 pacientes con IC tratados con inhibidores de la enzima conversora de angiotensinógeno o bloqueadores del receptor de la angiotensina, carvedilol, espironolactona, digital y furosemida. La etiología de la IC era enfermedad arterial coronaria en todos los pacientes. Los pacientes fueron evaluados mediante ecocardiografía y análisis de

  6. Freqüência cardíaca e risco cardiovascular Heart rate and cardiovascular risk

    Luiz Antonio Machado César

    2007-10-01

    Full Text Available A freqüência cardíaca (FC também está no centro das determinantes do tempo de vida dos seres vivos animais. Há quase uma constante quando se multiplica a FC pelo número de anos que, em média, vive um animal. O ser humano também tem correlações interessantes de tempo de vida e FC, com estudos epidemiológicos demonstrando maior sobrevivência naqueles com menor FC em repouso, hipertensos, com doença coronariana e na população geral. Neste artigo, revemos estes estudos epidemiológicos e a perspectiva de se, de fato reduzindo a FC, poderemos aumentar o tempo de vida, no caso dos pacientes com doença cardiovascular, de forma independente de outros fatores.Heart rate (HR is known to be one of the factors that in the animal world are related to mortality. When one multiplies resting HR by the average life time, for each animal species, the result is almost the same number, similar to a constant. Apparently, each class of living beings has its "maximal number of heart beats for a life". Herein considerations are made about the relationship between HR and survival in human beings. Some epidemiological studies are reviewed, especially those related to cardiovascular and coronary diseases correlated to deaths and discussions are directed towards the perspective of living longer by lowering the HR.

  7. Anemia nos pacientes com insuficiência cardíaca avançada

    Juliano Cardoso

    2010-10-01

    Full Text Available FUNDAMENTO: Anemia está associada à pior evolução nos pacientes com insuficiência cardíaca (IC. Entretanto, há poucos estudos sobre a anemia nos pacientes com IC avançada. OBJETIVO: Avaliar as características da anemia na IC em fase avançada. MÉTODOS: Foram incluídos 99 pacientes hospitalizados para compensação de IC (CF IV/NYHA, com idade > 18 anos e FEVE 12 g/dl. A anemia foi marcador independente de mau prognóstico na análise multivariada (mortalidade 47% vs 24,6%, p = 0,016, risco relativo 2,54. CONCLUSÃO: Anemia acomete, aproximadamente, 1/3 dos pacientes com IC avançada, e a deficiência de ferro é uma importante etiologia. Pacientes anêmicos são mais idosos e apresentaram função renal mais deteriorada. A melhora da congestão não foi suficiente para melhorar a anemia na maioria dos casos. Nos pacientes com IC avançada, a anemia é marcador independente de mau prognóstico.

  8. Manifestaciones digestivas y extradigestivas de la enfermedad celíaca.

    Luis Ortigosa

    2009-11-01

    Full Text Available La enfermedad celíaca (EC es una enteropatía de base autoinmune que se manifiesta en sujetos genéticamente susceptibles, asociada con genes que codifican para las moléculas HLA DQ2 (DQ A1*0501/DQB1*0201 y DQ8 (DQA1*0301/ DQB1*0302. Se caracteriza por una respuesta inmunológica a la ingesta del gluten de trigo y otras prolaminas relacionadas del centeno y la cebada. Las manifestaciones clínicas son diversas, puede haber formas sintomáticas digestivas “clásicas” en niños, y formas extradigestivas en personas de todas las edades. Las manifestaciones atípicas y extradigestivas contribuyen cada vez más a dificultar y demorar el diagnóstico de EC. El uso de marcadores serológicos, especialmente los anticuerpos contra la transglutaminasa tisular, facilita el proceso diagnóstico inicial, que se debe confirmar con una biopsia intestinal para poner de manifiesto unas lesiones histológicas características, con grados variables de atrofia vellositaria, hiperplasia de las criptas e infiltrado linfocitario.

  9. Women's Health Coverage Since the ACA: Improvements for Most, But Insurer Exclusions Put Many at Risk.

    Palanker, Dania; Davenport, Karen

    2016-08-01

    Issue: Since enactment of the Affordable Care Act (ACA), many more women have health insurance than before the law, in part because it prohibits insurer practices that discriminate against women. However, gaps in women's health coverage persist. Insurers often exclude health services that women are likely to need, leaving women vulnerable to higher costs and denied claims that threaten their economic security and physical health. Goal: To uncover the types and incidence of insurer exclusions that may disproportionately affect women's coverage. Method: The authors examined qualified health plans from 109 insurers across 16 states for 2014, 2015, or both years. Key findings and conclusions: Six types of services are frequently excluded from insurance coverage: treatment of conditions resulting from noncovered services, maintenance therapy, genetic testing, fetal reduction surgery, treatment of self-inflicted conditions, and preventive services not covered by law. Policy change recommendations include prohibiting variations within states' "essential health benefits" benchmark plans and requiring transparency and simplified language in plan documents. PMID:27483555

  10. Cirurgia cardíaca no idoso Cardiac surgery in elderly patients

    Danton R. da Rocha LOURES

    2000-03-01

    Full Text Available Com o aumento da expectativa de vida da população brasileira cresce o número de pessoas com idade superior a 70 anos que necessitam de operação cardíaca. CASUÍSTICA E MÉTODOS: Foram avaliados, retrospectivamente, 75 pacientes com idade 3 a 70 anos submetidos a operação cardíaca no HC-UFPR, entre 1995 e 1999, com objetivo de analisarmos os resultados imediatos e tardios. A idade variou de 70 a 88 anos, sendo 34 (46,7% do sexo feminino e 41 (53,3% do masculino. Os principais sintomas foram angina (81,3%, dispnéia (42,6% e síncope (16%. Os pacientes encontravam-se em classe I (57,3%, classe II (17,3%, classe III (18,6% e classe IV (6,6% da NYHA, 61,3% eram hipertensos, 48% tabagistas, 28% diabéticos e 9,3% haviam sido submetidos a operação cardíaca prévia. Foram realizadas 50 (66,6% revascularizações do miocárdio, 9 (12% trocas de valva aórtica, 5 (6,6% operações de aorta, 4 (5,2% trocas valvares + revascularização miocárdica e outros procedimentos (7%. As principais complicações pós-operatórias foram cardiovasculares: arritmias ventriculares (22,6%, arritmias supraventriculares (21,3%, baixo débito cardíaco (16%; infecciosas (16% e pulmonares (9,3%. O tempo médio de permanência na UTI foi de 5 dias. RESULTADOS: A mortalidade hospitalar foi de 13,3% e houve 5 óbitos tardios. Dos sobreviventes, 78,4% compareceram para seguimento ambulatorial. O tempo médio de seguimento foi de 20,7 meses e a sobrevida foi de 92%; um dos óbitos tardios foi de origem cardiovascular. CONCLUSÃO: Apesar de serem pacientes de maior complexidade clínica pela maior incidência de doenças crônicas e acometimento de outros órgãos, os avanços na cirurgia cardíaca e terapia intensiva tornaram possível a intervenção com baixa morbi-mortalidade.BACKGROUND: Because of the increase in the life expectancy of the Brazilian population, elderly patients are being increasingly referred to cardiac surgery. MATERIAL AND METHODS: Seventy

  11. Infusión intermitente de inotrópicos en la insuficiencia cardíaca avanzada

    Héctor O Ventura

    2001-08-01

    Full Text Available Es conveniente seleccionar adecuadamente a los pacientes en los que se administrará terapia con agentes inotrópicos. Se deben descartar potenciales causas reversibles de insuficiencia cardíaca y evaluar factores que puedan precipitar una descompensación. Los pacientes deben estar tratados con dosis máximas de medicamentos convencionales. Los niveles electrolíticos, especialmente potasio y magnesio deben ser controlados periódicamente con el fin de evitar arritmias, manteniendo el potasio por encima de 4mEq/L y el magnesio por encima de 2mEq/L, y evitar que los niveles de digoxina sean mayores de 2ng/dl. Deben seguir adecuadamente las instrucciones médicas y ser dotados de una educación adecuada acerca de su enfermedad junto con sus familiares cercanos. En conclusión, las indicaciones para el uso de agentes inotrópicos en el tratamiento de insuficiencia cardíaca avanzada deberían estar limitadas a: 1. Pacientes que estén en espera de trasplante cardíaco en los que se pueda utilizarlos como un puente hasta que sean trasplantados. 2. Se puede utilizarlos a corto plazo después de cirugía cardíaca para dar un soporte adecuado, hasta que el corazón del paciente comience a funcionar adecuadamente. 3. Como ya hemos discutido extensamente, se pueden utilizar en pacientes con insuficiencia cardíaca inestable y refractaria, como un puente hacia el uso de beta bloqueantes. 4. En pacientes con descompensación aguda. 5. Finalmente se deberían utilizar en pacientes con insuficiencia cardíaca avanzada y que no son candidatos a trasplante cardíaco, en los cuales es indispensable brindarles una calidad de vida mas digna. Idealmente, deben ser los pacientes los que escojan entre un tipo de medicamento que puede mejorar sus síntomas, pero a expensas de una disminución de su sobrevida. Es decir, poder escoger entre calidad versus cantidad.

  12. Resonancia magnética cardíaca: aplicaciones clínicas Cardiac magnetic resonance: clinical applications

    G. Bastarrika

    2005-04-01

    Full Text Available La enfermedad cardiovascular es la causa más frecuente de mortalidad en los países desarrollados y constituye un grave problema social, económico y sanitario. Aunque existen muy diversas técnicas útiles para diagnosticar las enfermedades cardíacas, con frecuencia es preciso realizar más de una prueba para llegar a un diagnóstico concreto. La resonancia magnética es una técnica inocua, bien tolerada y segura que actualmente se encuentra disponible en la mayoría de los centros hospitalarios. Esta técnica permite estudiar en una única exploración la anatomía del corazón y valorar de forma cualitativa, semicuantitativa y cuantitativa los parámetros de función cardíaca. Es útil para el estudio de las enfermedades valvulares, miocardiopatías y de la enfermedad pericárdica. Aporta información de la anatomía y función cardíaca y vascular en las cardiopatías congénitas complejas. Además, con la administración de contraste intravenoso, permite conocer la viabilidad miocárdica en la cardiopatía isquémica. Por tanto, la resonancia magnética cardíaca se perfila como una de las técnicas más prometedoras para el estudio de la patología cardíaca congénita y adquirida.Cardiovascular disease is the most frequent cause of mortality in the developed countries and represents a serious social, economic and health problem. Although very diverse, useful techniques exist for diagnosing cardiac diseases, it is frequently necessary to ask for more than one test to reach a specific diagnosis. Magnetic resonance is a harmless, well tolerated and safe technique, which is currently available in the majority of hospitals. This technique makes it possible in a single exploration to study the anatomy of the heart and to make a qualitative, semi-quantitative and quantitative assessment of the parameters of cardiac function. It provides information of cardiac and vascular anatomy and function in complex congenital cardiopathies. Besides

  13. Supplemental instruction in chemistry

    Lundeberg, Mary A.

    This study was designed to measure some effects of supplemental instruction in chemistry. Supplemental instruction is a peer-led cooperative learning program that encourages students to develop conceptual understanding by articulating both understandings and misconceptions in a think-aloud fashion. Supplemental instruction was offered three hours weekly outside of class and lab time for students in four classes of General Organic and Biological Chemistry. Over a two-year period 108 students volunteered to participate in this program; 45 students did not participate. As measured by final grades in chemistry and responses to a questionnaire, supplemental instruction was effective in increasing students' achievement in chemistry. Further research is needed to determine the in-depth effects of supplemental instruction on students' learning, problem solving, and self-esteem.

  14. Herbs, Supplements and Alternative Medicines

    ... Size: A A A Listen En Español Herbs, Supplements and Alternative Medicines It is best to get ... also more likely to use dietary supplements. Using Supplements Safely If you’re one of the many ...

  15. On closed weak supplemented modules

    ZENG Qing-yi; SHI Mei-hua

    2006-01-01

    A module M is called closed weak supplemented if for any closed submodule N of M, there is a submodule K of M such that M=K+N and K(c)N<<M. Any direct summand of closed weak supplemented module is also closed weak supplemented.Any nonsingular image of closed weak supplemented module is closed weak supplemented. Nonsingular V-rings in which all nonsingular modules are closed weak supplemented are characterized in Section 4.

  16. Dietary supplements in sport.

    Burke, L M; Read, R S

    1993-01-01

    Studies of the dietary practices of athletes report that nutritional supplements are commonly used. Supplementation practices vary between sports and individual athletes; however, there is evidence that at least some athletes use a large number of supplements concurrently, often in doses that are very high in comparison with normal dietary intakes. In exploring supplementation practices we propose a classification system separating the supplements into dietary supplements and nutritional erogogenic aids. The dietary supplement is characterised as a product which can be used to address physiological or nutritional issues arising in sport. It may provide a convenient or practical means of consuming special nutrient requirements for exercise, or it may be used to prevent/reverse nutritional deficiencies that commonly occur among athletes. The basis of the dietary supplement is an understanding of nutritional requirements and physiological effects of exercise. When the supplement is used to successfully meet a physiological/nutritional goal arising in sport it may be demonstrated to improve sports performance. While there is some interest in refining the composition or formulation of some dietary supplements, the real interest belongs to the use or application of the supplement; i.e. educating athletes to understand and achieve their nutritional needs in a specific sports situation. The sports drink (carbohydrate-electrolyte replacement drink) is a well known example of a dietary supplement. Scientific attitudes towards the sports drink have changed over the past 20 years. Initial caution that carbohydrate-electrolyte fluids compromise gastric emptying during exercise has now been shown to be unjustified. Numerous studies have shown that 5 to 10% solutions of glucose, glucose polymers (maltodextrins) and other simple sugars all have suitable gastric emptying characteristics for the delivery of fluid and moderate amounts of carbohydrate substrate. The optimal

  17. Cardiología intervencionista en arritmias cardíacas: experiencia inicial

    Oswaldo Gutiérrez

    2000-04-01

    Full Text Available Introducción. La cateterización del corazón en electrofisiología se ha venido utilizando con fines diagnósticos y para establecer el recorrido anatómico de las taquicardias supraventriculares o ventriculares y así detectar zonas críticas suceptibles de ablación. El objetivo de este estudio es brindar una revisión de los casos realizados desde febrero de 1999 hasta la fecha, en el país. Materiales y Métodos. Se incluyeron pacientes que tuvieran las indicaciones usuales para realizar estudio electrofisiológico diagnóstico o procedimientos de ablación por catéter. Se colocaron múltiples catéteres intracardíacos para el registro y estimulación de las cámaras cardíacas así como para la aplicacion de radiofrecuencia. Resultados. Se realizaron 19 estudios (5 diagnósticos y 14 terapéuticos, edades entre 16 y 86 años, 6 hombres y 12 mujeres. Los estudios diagnósticos se realizaron en 3 pacientes con síncope, uno con taquicardia ventricular sostenida y uno con extrasistolia ventricular frecuente. Los procedimientos terapéuticos se realizaron en 3 pacientes con reentrada intranodal (éxito 100%, en 10 con vías accesorias o síndrome de Wolff-Parkinson-White (éxito de 90% y en una se realizó ablación del nódulo Aurículoventricular (100% por crisis de fibrilación auricular de alta respuesta ventricular. Ocurrió recidiva en un caso (seguimiento de 2 a 38 semanas y una complicación en otro (derrame pericárdico. Conclusiones. Estos procedimientos de Cardiología Intervencionista en Arritmias Cardíacas son seguros, aportan información diagnóstica relevante y/o tratamiento curativo con alta tasa de éxito y baja tasa de recurrencia en pacientes con diversos trastornos del ritmo cardíaco.Introduction. Electrophysiological cardiac catheterization have been used for diagnostic purposes and for detection of anatomic circuits of different taquiarrhythmias, suitable for ablation procedures. The objetive of this study is to

  18. Interrelation of Preventive Care Benefits and Shared Costs under the Affordable Care Act (ACA

    Robert Dixon

    2014-08-01

    Full Text Available With the implementation of the Affordable Care Act (ACA, access to insurance and coverage of preventive care services has been expanded. By removing the barrier of shared costs for preventive care, it is expected that an increase in utilization of preventive care services will reduce the cost of chronic diseases. Early detection and treatment is anticipated to be less costly than treatment at full onset of chronic conditions. One concern of early detection of disease is the cost to treat. In reality, the confluence of early detection may result in greater overall expenditures. Even with improved access to preventive care benefits, cost-sharing of other health services remains a major component of insurance plans. In order to treat identified conditions or diseases, cost-sharing comes into play. With the greater adoption of cost-sharing insurance plans, expenditures on the part of enrollee are anticipated to rise. Once the healthcare recipients realize the implication of early identification and resultant treatment costs, enrollment in preventive care may decline. Healthcare legislation and regulation should consider the full spectrum of care and the microeconomic costs associated with preventive treatment. Although the system at large may not realize the immediate impact, behavioral shifts on the part of healthcare consumers may alter healthcare. Rather than the current status quo of treating presenting conditions, preventive treatment is largely anticipated to require more resources and may impact the consumer’s financial capacity. This report will explore how these two concepts are co-dependent, and highlight the need for continued reform.

  19. Cirurgia cardíaca na gravidez Cardiac surgery during pregnancy

    Antoninho Sanfins Arnoni

    1986-08-01

    Full Text Available No Instituto Dante Pazzanese de Cardiologia, vem sendo realizado, desde 1975, um trabalho conjunto reunindo obstetras, pediatras, cardiologistas, anestesistas e cirurgiões cardiovasculares, com o intuito de melhorar os resultados da cirurgia cardíaca realizada em pacientes grávidas. Para isto, organizamos um protocolo, que inclui desde o pré-operatório até o nascimento da criança, passando por estudos ecocardiográficos, ultrassonográficos e por monitorização fetal durante a cirurgia. Vinte e seis pacientes foram operadas durante a gravidez, sendo 6 delas em 1985, após o início do estudo. Os resultados, tanto do lado materno como do fetal, são bons, não ocorrendo nenhum óbito materno nesta série e com as crianças nascendo bem e sem malformações e com crescimento e desenvolvimento normais, até o 6º mês de vida extra-uterina.At the Instituto Dante Pazzanese de Cardiologia, a team project has been carried out since 1975, including obstetricians, pediatricians, cardiologists, anesthesiologists and cardiovascular surgeons aim at getting better results of cardiac surgery in pregnant women. For this purpose, the group developed a protocol that goes from the preoperative period to the delivery of the baby, with ecocardiographic and ultrasonic studies and fetal monitoring during the cardiac surgery of the mother. Twenty six patients were submited to cardiac surgery during pregnancy, and six patients after beginning the study, in 1985. The maternal and fetal results were good, without maternal death and the children were born without malformations and having had normal development until the sixth month of life.

  20. Relación entre los índices de funcionalidad cardíaca y cognitiva en personas mayores institucionalizadas

    Carmen Requena Hernández

    2014-12-01

    Full Text Available Los datos más recientes sugieren que la disfunción cardíaca, cuantificada por el gasto cardíaco, está relacionada con el funcionamiento cognitivo. Objetivo: determinar si el funcionamiento cardíaco actúa como predictor de la función cognitiva en personas institucionalizadas con índice cardíaco normal. Método: estudio observacional con una muestra de 30 sujetos mayores de 80 años, con historial médico clínico sin cardiopatías. Resultados: el análisis de regresión múltiple confirma que las variables cardíacas de riesgo cardiovascular e insuficiencia cardíaca son predictoras del nivel de funcionamiento cognitivo y acumulan un 95,1% de la varianza. Sin embargo, destaca la notable falta de correspondencia entre las medidas clínicas cardíacas y cognitivas con la medida biológica de índice cardíaco. Conclusión: aunque los datos observacionales no pueden establecer causalidad, nuestros resultados muestran que la función cardíaca con índice cardíaco normal se asocia con deterior cognitivo

  1. Improved performance of P3HT:PCBM solar cells by both anode modification and short-wavelength energy utilization using Tb(aca)3phen

    The performance of P3HT:PCBM solar cells was improved by anode modification using spin-coated Tb(aca)3phen ultrathin films. The modification of the Tb(aca)3phen ultrathin film between the indium tin oxide (ITO) anode and the PE-DOT:PSS layer resulted in a maximum power conversion efficiency (PCE) of 2.99% compared to 2.66% for the reference device, which was due to the increase in the short-circuit current density (Jsc). The PCE improvement could be attributed to the short-wavelength energy utilization and the optimized morphology of the active layers. Tb(aca)3phen with its strong down-conversion luminescence properties is suitable for the P3HT:PCBM blend active layer, and the absorption region of the ternary blend films is extended into the near ultraviolet region. Furthermore, the crystallization and the surface morphology of P3HT:PCBM films were improved with the Tb(aca)3phen ultrathin film. The ultraviolent—visible absorption spectra, atomic force microscope (AFM), and X-ray diffraction (XRD) of the films were investigated. Both anode modification and short-wavelength energy utilization using Tb(aca)3phen in P3HT:PCBM solar cells led to about a 12% PCE increase. (interdisciplinary physics and related areas of science and technology)

  2. Iron supplements (image)

    The mineral iron is an essential nutrient for humans because it is part of blood cells, which carry oxygen to all body cells. There is no conclusive evidence that iron supplements contribute to heart attacks.

  3. Breastfeeding: Vitamin D Supplementation

    ... Weight Breastfeeding Micronutrient Malnutrition State and Local Programs Vitamin D Supplementation Recommend on Facebook Tweet Share Compartir ... not provide infants with an adequate intake of vitamin D. Most breastfed infants are able to synthesize ...

  4. Realidad de la cirugía cardíaca en la República Argentina. Registro CONAREC XVI

    Diego M. Lowenstein Haber

    2010-01-01

    Full Text Available RESUMENIntroducciónLos dos grandes registros multicéntricos de cirugía cardíaca realizados en la Argentina,CONAREC y ESMUCICA, datan de más de 10 años. Considerando los avances médicosy quirúrgicos de la última década, surgió la necesidad de realizar un nuevo registronacional, prospectivo y multicéntrico para conocer las características, la evolución, lascomplicaciones y los predictores de mortalidad de los pacientes sometidos a cirugía cardíaca.ObjetivosConocer el perfil epidemiológico, la modalidad quirúrgica y la evolución posoperatoria de lospacientes sometidos a cirugía cardíaca en la Argentina.Material y métodosRegistro prospectivo, consecutivo y multicéntrico realizado en 49 centros cardioquirúrgicosde la República Argentina por residentes de cardiología. Se analizaron las características yla evolución de 2.553 pacientes sometidos a cirugía cardíaca entre septiembre de 2007 yoctubre de 2008: 1.465 (57,4% a cirugía coronaria, 359 (14,1% a reemplazo valvular aórtico,169 (6,6% a cirugía valvular mitral, 312 (12,2% a cirugía combinada coronariovalvular y248 (9,7% a otros procedimientos.ResultadosHubo predominio de hombres (74,9%; la edad promedio fue de 63 ± 11 años. La prevalenciade diabetes fue del 24,9%, la de hipertensión del 76,3% y la de insuficiencia cardíaca del17%. La disfunción ventricular moderada a grave prequirúrgica fue del 23,8% y el 19,8% delas cirugías fueron no programadas.En las cirugías coronarias, el 41,9% de ellas se realizaron sin circulación extracorpórea y seempleó puente mamario en el 89%.El 81,7% de las cirugías mitrales se indicaron por insuficiencia y el 62,6% de las aórticas,por estenosis. En estas cirugías se emplearon válvulas mecánicas en el 58% de los casos.La mediana de internación fue de 6 días. Se presentaron complicaciones mayores en el31,7% (del 25% en coronarios al 49,36% en combinados y la mortalidad global fue del 7,7%(del 4,3% en coronarios al 13

  5. Avaliação do sensor de contratilidade cardíaca em sistema DDDR: estudo multicêntrico

    ANDRADE José Carlos S.

    1998-01-01

    Full Text Available Introdução: O tratamento de distúrbios na condução atrioventricular associados a doenças do nó sinusal com o emprego de marcapassos DDDR tem incentivado a procura de um sensor ideal. Objetivo: Avaliar a resposta de freqüência do marcapasso com sensor de contratilidade em situações de esforço físico e mental, tanto em laboratório como em atividades diárias de pacientes com bradicardia e insuficiência cronotrópica. Casuística e Métodos: Do estudo multicêntrico brasileiro "Projeto Inos DR _ Brasil", que emprega um sistema de estimulação DDDR cujo indicador é o estado contrátil do miocárdio, foram selecionados 38 pacientes com insuficiência cronotrópica, sendo 21 do sexo masculino e 17 do sexo feminino, com idades variando de 13 a 83 anos (média de 57 anos. O marcapasso utiliza um parâmetro do próprio controle cardiovascular (contratilidade cardíaca obtida pela medida da impedância cardíaca unipolar para a adaptação da freqüência cardíaca, num sistema de malha fechada que, teoricamente, possibilita um ajuste a todas as necessidades fisiológicas. A calibração e programação do sistema só foi realizada 30 dias após o implante (tempo de maturação da irterface coração-eletrodo, realizando-se, então, teste de estresse mental (matemático e teste ergométrico (em esteira, monitorados com histograma de freqüência e com curvas de consumo de oxigênio. Resultados: A média de limiares agudos de estimulação foi de 0,82 Volts e 0,55 Volts, e a média de limiares de sensibilidade foi de 2,37 mV e 10,61 mV, respectivamente, para átrios e ventrículos. A média de limiares crônicos de estimulação foi de 1,44 Volts e 1,18 Volts, e a média de limiares de sensibilidade foi de 2,81 mV e 6,3 mV, respectivamente para átrios e ventrículos. A freqüência cardíaca variou de 5% a 128% nas atividades físicas e de 5% a 80% nas atividades mentais, com elevação logo no início das atividades, permitindo uma curva

  6. Antioxidant supplements and mortality

    Bjelakovic, Goran; Nikolova, Dimitrinka; Gluud, Christian

    2014-01-01

    Oxidative damage to cells and tissues is considered involved in the aging process and in the development of chronic diseases in humans, including cancer and cardiovascular diseases, the leading causes of death in high-income countries. This has stimulated interest in the preventive potential of a...... antioxidant supplements. Today, more than one half of adults in high-income countries ingest antioxidant supplements hoping to improve their health, oppose unhealthy behaviors, and counteract the ravages of aging....

  7. Active components in food supplements

    Siemelink M; Jansen EHJM; Piersma AH; Opperhuizen A; LEO

    2000-01-01

    The growing food supplement market, where supplements are both more diverse and more easily available (e.g. through Internet) formed the backdrop to the inventory of the active components in food supplements. The safety of an increased intake of food components via supplements was also at issue her

  8. Insuficiência renal aguda em pacientes internados por insuficiência cardíaca descompensada - Reincade

    Larissa Cristina Nascimento de Barros; Fábio Serra Silveira; Marcos Serra Silveira; Thamara Carvalho Morais; Marco Antônio Prado Nunes; Kleyton de Andrade Bastos

    2012-01-01

    INTRODUÇÃO: Insuficiência renal aguda (IRA) acontece com frequência em pacientes críticos, porém a significância clínica de sua ocorrência não tem sido determinada na insuficiência cardíaca descompensada (ICD). OBJETIVOS: Estudar a ocorrência e valor prognóstico da IRA em pacientes internados por ICD e avaliar comparativamente com aqueles sem a complicação o perfil clínico-laboratorial e a mortalidade intra-hospitalar. MÉTODOS: Estudo prospectivo em 85 pacientes internados em terapia intensiv...

  9. Optical properties of $A$Fe$_\\mathbf{2}$As$_\\mathbf{2}$ ($A=\\,$Ca, Sr, and Ba) single crystals

    Dai, Y. M.; Akrap, A.; Bud'ko, S. L.; Canfield, P. C.; Homes, C. C.

    2016-01-01

    The detailed optical properties have been determined for the iron-based materials $A$Fe$_2$As$_2$, where $A=\\,$Ca, Sr, and Ba, for light polarized in the iron-arsenic ($a-b$) planes over a wide frequency range, above and below the magnetic and structural transitions at $T_N =\\,$138, 195, and 172~K, respectively. The real and imaginary parts of the complex conductivity are fit simultaneously using two Drude terms in combination with a series of oscillators. Above $T_N$, the free-carrier respon...

  10. El sildenafil mejora la capacidad de ejercicio en pacientes con insuficiencia cardíaca crónica

    Clemente H. Magallanes

    2010-01-01

    Full Text Available AntecedentesLos agentes inhibidores de la fosfodiesterasa 5, como el sildenafil, son vasodilatadores moderados ampliamente utilizados para el tratamiento de la disfunción eréctil. En la actualidad, la evidencia disponible establece su potencial aplicación en otras patologías, como la hipertensión pulmonar, la disfunción endotelial y la insuficiencia cardíaca crónica. ObjetivoEl presente estudio fue diseñado para comprobar si la administración de sildenafil en pacientes con insuficiencia cardíaca crónica en clase funcional II-III mejora la capacidad de ejercicio en comparación con placebo.Material y métodosSe seleccionaron en forma aleatoria 70 pacientes portadores de insuficiencia cardíaca crónica de cualquier etiología, excepto valvulares, todos con tratamiento óptimo. Para su inclusión en el estudio, los pacientes debían tener un diámetro diastólico ventricular izquierdo > 55 mm, una fracción de eyección 90 mm Hg. Se excluyeron los que se encontraban anémicos, aquellos con indicación de cirugía por cualquiercausa o los que por diversos motivos no pudieran realizar una caminata de seis minutos. Luego de una caminata de seis minutos fueron aleatorizados para recibir 50 mg de sildenafil o placebo, conformándose dos grupos, placebo y sildenafil, ambos con 35 participantes. Luego de 1 hora de la ingestión de las drogas se realizó una nueva caminata de seis minutos. Antes y después de cada caminata se controlaron las siguientes variables: presión arterial sistólica, diastólica y frecuencia cardíaca; se registraron también los metros caminados en cada prueba.ResultadosCaracterísticas generales, grupo placebo versus grupo sildenafil: hombres: 74% vs 88%, etiología isquémico-necrótica: 71% vs 77%, clase funcional II: 37% vs 34%, clase funcional III: 63% vs 66%, edad: 68 ± 10 vs 68 ± 12 años, fracción de eyección: 26,5% ± 7,8% vs 26,5% ± 6,5%, diámetro diastólico ventricular izquierdo: 65 ± 6 vs 66 ± 9

  11. Análisis comportamental aplicado (ACA) y trastornos generalizados del desarrollo (TGD): su evaluación en Argentina

    María de los Angeles Matos; Alba Elisabeth Mustaca

    2005-01-01

    Se presentan los resultados obtenidos con la intervención basada en Análisis Comportamental Aplicado (ACA) o manejo de contingencias, en 9 niños (8 varones y 1 mujer) de 2 a 5 años con Trastornos Generalizados del Desarrollo (TGD). Este tratamiento basado en métodos desarrollados por Lovaas y colaboradores (1981) fue implementado en una institución argentina especializada. Se evaluaron las siguientes áreas: comprensión del lenguaje, funciones del comportamiento, nivel ...

  12. Controle microbiológico em valvas cardíacas humanas Microbiologyc control in human heart valves

    Angela Maria Peruzzo; Francisco Diniz Affonso da Costa; Wanda Moscalewski Abrahão

    2006-01-01

    OBJETIVO: Avaliar, sob o aspecto microbiológico, valvas processadas pelo Banco de Valvas Cardíacas Humanas da Irmandade da Santa Casa de Misericórdia de Curitiba, para serem utilizadas em cirurgias cardiovasculares. MÉTODOS: Foi avaliado o processamento de 1.671 valvas, no período de junho de 1999 a junho de 2004. Das valvas e soluções envolvidas no processo foram coletadas amostras e semeadas nos meios de cultura: meio líquido tioglicolato, caldo soja tripticaseína e caldo Sabouraud, com qua...

  13. Efeitos da Effleurage de diferentes pressões na função cardíaca

    Moreira, Nídia Maria Gomes

    2014-01-01

    Objectivo: Determinar os efeitos da effleurage de diferentes pressões na função cardíaca. Metodologia: Foram seleccionadas 30 pessoas com as idades compreendidas entre os 20 a 25 anos todos do género masculino e sem patologias. Estes jovens foram divididos aleatoriamente em três grupos: grupo controlo (GC) (N=10), grupo effleurage superficial (GES) (N=10) e grupo effleurage profunda (GEP) (N=10). Foi utilizado um metrónomo para monitorizar a respiração, tendo sido utilizado um polar e um esfi...

  14. Cèl·lules mare mesenquimals humanes: aïllament, caracterització i potencialitat per a la regeneració cardíaca

    Farré Crespo, Jordi

    2008-01-01

    La insuficiència cardíaca congestiva és una epidèmia creixent a nivell mundial. Les causes principals de la insuficiència cardíaca estan relacionades amb el dany irreversible que resulta d'un infart de miocardi. El cor humà té una capacitat de regeneració limitada, i la pèrdua de múscul, juntament amb la contracció i la fibrosi de la cicatriu miocàrdica, posen en joc un conjunt d'esdeveniments anomenats remodelat ventricular, que finalment tendeixen cap a una insuficiència cardíaca congestiva...

  15. Perfil clínico y funcional de los pacientes con insuficiencia cardíaca sistólica y disfunción renal

    ADRIANA ACOSTA; MÁXIMO MIGLIORI; NORA VAINSTEIN; JAVIER C. MARINO; RAMIRO GUGLIELMONE; MARCELO S. TRIVI; MÓNICA SULTÁN; FERNANDO BRITES; JORGE M. THIERER

    2009-01-01

    RESUMENIntroducciónLa disfunción renal está fuertemente asociada con la insuficiencia cardíaca crónica. Es unacomplicación habitual y progresiva de esta condición, con una evolución clínica que fluctúacon la clase funcional y el tratamiento farmacológico.ObjetivosDefinir la prevalencia y el perfil clínico y funcional de pacientes con disfunción renal en elcontexto de insuficiencia cardíaca con baja fracción de eyección.Material y métodosEn 132 pacientes con insuficiencia cardíaca y fracción d...

  16. Aneurisma de artéria ilíaca interna roto: relato de caso Ruptured internal iliac artery aneurysm: case report

    Cristina Toledo Afonso; Ricardo Jayme Procópio; Túlio Pinho Navarro; Gustavo Henrique Dumont Kleinsorge; Beatriz Deoti e Silva Rodrigues; Marco Antônio Gonçalves Rodrigues

    2009-01-01

    Aneurismas isolados da artéria ilíaca interna são raros, acometem 0,1% da população e correspondem a 1% dos aneurismas aorto-ilíacos. Na maioria das vezes, os pacientes são assintomáticos, mas podem apresentar dor abdominal, massa pulsátil no hipogástrio ou na fossa ilíaca, sintomas compressivos urinários, gastrointestinais ou neurológicos. Podem ocasionar quadro de abdome agudo, principalmente quando há ruptura. O diagnóstico precoce dos aneurismas isolados de artéria ilíaca interna é incomu...

  17. Supplement use by Young Athletes

    Jill Anne McDowall

    2007-01-01

    This paper reviews studies of supplement use among child and adolescent athletes, focusing on prevalence and type of supplement use, as well as gender comparisons. Supplement use among adult athletes has been well documented however there are a limited number of studies investigating supplement use by child and adolescent athletes. A trend in the current literature revealed that the most frequently used supplements are in the form of vitamin and minerals. While health and illness prevention a...

  18. Comparação de critérios diagnósticos de insuficiência renal aguda em cirurgia cardíaca

    2013-01-01

    FUNDAMENTO: Há grande controvérsia quanto ao diagnóstico de Insuficiência Renal Aguda (IRA), existindo mais de 30 diferentes definições. OBJETIVO: Avaliar a incidência e os fatores de risco para desenvolvimento de IRA no pós-operatório de cirurgia cardíaca de acordo com os critérios RIFLE, AKIN e KDIGO, e comparar o poder prognóstico desses critérios. MÉTODOS: Estudo de corte transversal que incluiu 321 pacientes (62 [53 - 71] anos, 140 homens) consecutivamente submetidos a cirurgia cardíaca ...

  19. Prevalência de doença celíaca em crianças e adolescentes com miocardite e cardiomiopatia dilatada

    Thaysa Maria Gama Albuquerque Leão de Menezes

    2012-10-01

    Full Text Available OBJETIVO: Determinar a prevalência de doença celíaca em pacientes portadores de cardiomiopatia dilatada e miocardite. MÉTODOS: Foram avaliados 56 pacientes, com idade entre 1 e 18 anos, portadores de cardiomiopatia dilatada ou miocardite, acompanhados no Instituto Materno Infantil Professor Fernando Figueira. Foram excluídos pacientes com diagnóstico prévio de doença celíaca. A classe funcional da insuficiência cardíaca foi determinada segundo os critérios da American Heart Association, como classe funcional I, II, III e IV. O diagnóstico de miocardite foi relatado em prontuário, e o de cardiomiopatia dilatada, pelo ecocardiograma, a partir da presença de disfunção sistólica de um ou ambos os ventrículos, com fração de ejeção menor que 55% e dilatação ventricular, com diâmetro diastólico final ventricular esquerdo maior que 112%. Nos pacientes incluídos no estudo, foi aplicado um formulário com informações sobre sintomatologia gastrointestinal e cardiológica; em seguida, dosadas sorologias para anticorpos antitransglutaminase tecidual humana e antiendomísio. Aqueles com sorologia positiva foram encaminhados à biópsia intestinal para avaliação histológica para doença celíaca, segundo os critérios de Marsh. RESULTADOS: Uma das 56 crianças apresentou sorologia antitransglutaminase positiva (1,8%, porém anticorpo antiendomísio negativo. A histologia intestinal demonstrou atrofia total das vilosidades. Cerca de 30% dos pacientes apresentaram insuficiência cardíaca. Sinais e sintomas gastrointestinais foram frequentes nos pacientes, em especial dor abdominal (70%, 39/56. CONCLUSÃO: A frequência de doença celíaca em pacientes com cardiomiopatia dilatada e miocardite foi de 1,8%. É importante investigar doença celíaca nos pacientes com essas doenças cardíacas para evitar evolução das doenças e deterioração clínica do paciente.

  20. Variabilidad de la frecuencia cardíaca en individuos sanos costarricenses

    Oswaldo Gutiérrez Sotelo

    2000-04-01

    Full Text Available Introducción. El análisis de la variabilidad de la frecuencia cardíaca (VFC, refleja la influencia autonómica sobre el corazón pudiendo ser predictivo de mortalidad. Consiste en el análisis de las variaciones de los intervalos RR. Este estudio analizó la VFC en individuos sanos costarricenses. Materiales y Métodos. Fueron elegidos adultos asintomáticos. En la adquisición de datos se utilizó una derivación electrocardiográfica estándar y se calcularon variables tanto en Dominio de Tiempo como en Dominio de Frecuencia. Se compararon los resultados desde registros de 5 minutos y de 10 minutos y se compararon diferentes grupos etáreos dividiéndose a la población en grupos: 18 a 29 años, 30 a 39 y 40 y también entre Introduction. Heart rate variability analysis evaluate the autonomic influence over the heart and therefore, is a predictive tool of mortality. It consists in the analysis of the variations in RR intervals. This study assessed heart rate variability in healthy costarrican people. Materials and Methods. We included adult healthy volunteers. For data adquisition we used a single electrocardiographic lead and calculate time and frequency domain variables. We compared results between 5 minutes versus 10 minutes samples and between age groups: 18 to 29 years old, versus 30 to 39 versus 40 or < 25 years old versus 25. Results. We studied 48 subjects, 25 women and 23 men (range 18 y 53. We do not obtained differences between time of data adquisition samples but find differences between 18-29 vs 40 and <25 vs 25 age groups in NN50 (231.432 vs 34.500, p = 0.004 in the fisrt group, 237.250 vs 53.250, p<0.001, the second, %NN50 (30.732 vs 5.2, p=0.003 and 31.444 vs 9.742, p=0.001 respectively, LF (457.338 vs 173.393, p=0.045 and 466.816 vs 259.361, p=0.042 respectively and HF (750.667 vs 239.865, p=0.068 and 766.834 vs 248.436, p=0.010 respectively. Conclusions. This study support reference values for comparision or to individual

  1. Layout Design of Human-Machine Interaction Interface of Cabin Based on Cognitive Ergonomics and GA-ACA.

    Deng, Li; Wang, Guohua; Yu, Suihuai

    2016-01-01

    In order to consider the psychological cognitive characteristics affecting operating comfort and realize the automatic layout design, cognitive ergonomics and GA-ACA (genetic algorithm and ant colony algorithm) were introduced into the layout design of human-machine interaction interface. First, from the perspective of cognitive psychology, according to the information processing process, the cognitive model of human-machine interaction interface was established. Then, the human cognitive characteristics were analyzed, and the layout principles of human-machine interaction interface were summarized as the constraints in layout design. Again, the expression form of fitness function, pheromone, and heuristic information for the layout optimization of cabin was studied. The layout design model of human-machine interaction interface was established based on GA-ACA. At last, a layout design system was developed based on this model. For validation, the human-machine interaction interface layout design of drilling rig control room was taken as an example, and the optimization result showed the feasibility and effectiveness of the proposed method. PMID:26884745

  2. Factors Affecting Health Insurance Enrollment Through the State Marketplaces: Observations on the ACA's Third Open Enrollment Period.

    Giovannelli, Justin; Curran, Emily

    2016-07-01

    Issue: Nearly 12.7 million individuals signed up for coverage in the Affordable Care Act's (ACA) health insurance marketplaces during the third open enrollment period, and by the end of March there were 11.1 million consumers with active coverage. States that operate their own marketplaces posted a year-to-year enrollment gain of 8.8 percent. To maintain membership and attract new consumers, the state-based marketplaces must sponsor enrollment assistance programs and conduct consumer outreach. These marketplaces relied heavily on such efforts during the third enrollment period, despite declining funding. Goal: To learn which outreach strategies, assistance programs, and other factors marketplace officials viewed as having exerted the greatest influence on enrollment. Methods: Survey of officials representing each of the 17 state-based marketplaces (15 responses). Key findings and conclusions: The cost of coverage and low health insurance literacy pose significant barriers to enrollment for many consumers. Marketplaces sought to overcome them by encouraging consumers to obtain in-person enrollment assistance from ACA-created assistance programs and from insurance brokers, and by partnering with community organizations for outreach activities. Many marketplaces also enhanced their web portals to make them easier to navigate and to give consumers better tools with which to evaluate their coverage options. PMID:27459742

  3. Evidence Suggests That The ACA's Tobacco Surcharges Reduced Insurance Take-Up And Did Not Increase Smoking Cessation.

    Friedman, Abigail S; Schpero, William L; Busch, Susan H

    2016-07-01

    To account for tobacco users' excess health care costs and encourage cessation, the Affordable Care Act (ACA) allowed insurers to impose a surcharge on tobacco users' premiums for plans offered on the health insurance exchanges, or Marketplaces. Low-income tax credits for Marketplace coverage were based on premiums for non-tobacco users, which means that these credits did not offset any surcharge costs. Thus, this policy greatly increased out-of-pocket premiums for many tobacco users. Using data for 2011-14 from the Behavioral Risk Factor Surveillance System, we examined the effect of tobacco surcharges on insurance status and smoking cessation in the first year of the exchanges' implementation, among adults most likely to purchase insurance from them. Relative to smokers who faced no surcharges, smokers facing medium or high surcharges had significantly reduced coverage (reductions of 4.3 percentage points and 11.6 percentage points, respectively), but no significant differences in smoking cessation. In contrast, those facing low surcharges showed significantly less smoking cessation. Taken together, these findings suggest that tobacco surcharges conflicted with a major goal of the ACA-increased financial protection-without increasing smoking cessation. States should consider these potential effects when deciding whether to limit surcharges to less than the federal maximum. PMID:27385231

  4. Layout Design of Human-Machine Interaction Interface of Cabin Based on Cognitive Ergonomics and GA-ACA

    Li Deng

    2016-01-01

    Full Text Available In order to consider the psychological cognitive characteristics affecting operating comfort and realize the automatic layout design, cognitive ergonomics and GA-ACA (genetic algorithm and ant colony algorithm were introduced into the layout design of human-machine interaction interface. First, from the perspective of cognitive psychology, according to the information processing process, the cognitive model of human-machine interaction interface was established. Then, the human cognitive characteristics were analyzed, and the layout principles of human-machine interaction interface were summarized as the constraints in layout design. Again, the expression form of fitness function, pheromone, and heuristic information for the layout optimization of cabin was studied. The layout design model of human-machine interaction interface was established based on GA-ACA. At last, a layout design system was developed based on this model. For validation, the human-machine interaction interface layout design of drilling rig control room was taken as an example, and the optimization result showed the feasibility and effectiveness of the proposed method.

  5. Ergogenic Aids and Supplements.

    Porrini, Marisa; Del Boʼ, Cristian

    2016-01-01

    Great interest is currently shown for the contribution of nutrition to optimize training and athletic performance, and a considerable debate exists about the potential ergogenic value of several dietary supplements. However, most of the products used by athletes do not provide sufficient scientific evidence regarding their efficacy in enhancing physical performance as well as their specificity of action and safety. For this reason, sport nutrition professionals need skills in evaluating the scientific value of papers and advertisements on ergogenic aids and supplements in order to support athletes in their choice. In the present chapter, the efficacy of some of the most popular supplements used by athletes and sport practitioners will be discussed. Particular attention will be devoted to amino acids and derivatives, caffeine and caffeinated energy drinks, and some antioxidants. PMID:27348226

  6. Determinants of dietary supplement use - healthy individuals use dietary supplements

    Kofoed, Christina L F; Christensen, Jane; Dragsted, Lars Ove;

    2015-01-01

    The prevalence of dietary supplement use varies largely among populations, and previous studies have indicated that it is high in the Danish population compared with other European countries. The diversity in supplement use across countries indicates that cultural and environmental factors could...... influence the use of dietary supplements. Only few studies investigating the use of dietary supplements have been conducted in the Danish population. The present cross-sectional study is based on 54 948 Danes, aged 50-64 years, who completed self-administrated questionnaires on diet, dietary supplements and...... intake of dietary supplements. We found that 71 % of the participants were dietary supplement users; female sex, older age groups and higher educated participants were more likely to be users of any dietary supplements. One additional point in the health index was associated with 19, 16 and 9 % higher...

  7. Supplemental TV Taped Problems.

    Squires, Robert G.; Frank, David V.

    1983-01-01

    Videotapes were developed as supplemental material for a course in chemical engineering thermodynamics. Describes the course, videotapes produced (includes list by topics as related to course content), and effectiveness of the tapes. Although no significant improvement in test performance was noted, students indicated they learned material faster…

  8. Oral Supplementation of Myoinositol

    Gregersen, G.; Bertelsen, B.; Harbo, H.;

    1983-01-01

    28 young diabetics with short disease duration participated in a double-blind study by taking 6 g of myoinositol or placebo daily for 2 months. The aim was to demonstrate a possible beneficial effect of this compound on subclinical diabetic neuropathy. Measurement of vibratory perception threshol...... of myoinositol in their muscle tissue remained uninfluenced by oral supplementation of myoinositol....

  9. Psychology: Teacher Supplement.

    Stark, Rebecca

    This supplement provides teachers with tests, quizzes, answers to questions in the text, and general teaching information for using the student text, "Psychology," by Rebecca Stark. Quizzes included are on the topics of human development; the nervous system; the brain; cognitive development; sensation and perception; conditioning; learning;…

  10. Abbott radiative energy attenuation method for quantifying ethanol evaluated and compared with gas-liquid chromatography and the Du Pont aca.

    Cary, P L; Whitter, P D; Johnson, C A

    1984-11-01

    Quantification of ethanol by a radiative energy attenuation (REA) technique was evaluated and compared with results by gas-liquid chromatography (GLC) and by the Du Pont aca. Within-assay CVs were less than 5.5%. Between-assay CVs ranged from 1.9% to 6.0% for serum and blood controls at concentrations of 0.5, 1.0, and 2.5 g/L. We observed no cross reactivity with methanol, isopropanol, or acetone, and analytical recovery of ethanol from serum averaged 101%. For the three-method comparison we performed parallel determinations of 156 blood, 92 serum, and 54 urine samples containing a wide range of ethanol concentrations. Linear regression analysis of the REA results vs those of GLC or aca yielded the following: for serum, REA = 1.03 GLC -0.03 (r = 0.998), REA = 1.13 aca -0.04 (r = 0.999); for blood, REA = 0.97 GLC + 0.05 (r = 0.994), REA = 0.99 aca + 0.06 (r = 0.996); and for urine, REA = 1.01 GLC -0.03 (r = 0.998). We also discuss the clinical and forensic use of the REA method for ethanol. PMID:6386230

  11. Vitamin Supplements: Healthy or Hoax?

    ... Recognition & Awards Healthy Workplace Food and Beverage Toolkit Vitamin Supplements: Healthy or Hoax? Updated:Jun 12,2015 Can vitamin and mineral supplements really make you healthier? Overwhelmed ...

  12. Dietary Supplements: What Is Safe?

    ... articles window. My Saved Articles » My ACS » Dietary Supplements: What Is Safe? Download Printable Version [PDF] » Dietary supplements include things like vitamins, minerals, herbs, or products ...

  13. Weight Loss Nutritional Supplements

    Eckerson, Joan M.

    Obesity has reached what may be considered epidemic proportions in the United States, not only for adults but for children. Because of the medical implications and health care costs associated with obesity, as well as the negative social and psychological impacts, many individuals turn to nonprescription nutritional weight loss supplements hoping for a quick fix, and the weight loss industry has responded by offering a variety of products that generates billions of dollars each year in sales. Most nutritional weight loss supplements are purported to work by increasing energy expenditure, modulating carbohydrate or fat metabolism, increasing satiety, inducing diuresis, or blocking fat absorption. To review the literally hundreds of nutritional weight loss supplements available on the market today is well beyond the scope of this chapter. Therefore, several of the most commonly used supplements were selected for critical review, and practical recommendations are provided based on the findings of well controlled, randomized clinical trials that examined their efficacy. In most cases, the nutritional supplements reviewed either elicited no meaningful effect or resulted in changes in body weight and composition that are similar to what occurs through a restricted diet and exercise program. Although there is some evidence to suggest that herbal forms of ephedrine, such as ma huang, combined with caffeine or caffeine and aspirin (i.e., ECA stack) is effective for inducing moderate weight loss in overweight adults, because of the recent ban on ephedra manufacturers must now use ephedra-free ingredients, such as bitter orange, which do not appear to be as effective. The dietary fiber, glucomannan, also appears to hold some promise as a possible treatment for weight loss, but other related forms of dietary fiber, including guar gum and psyllium, are ineffective.

  14. Há evidências favorecendo o uso de betabloqueadores e dobutamina na insuficiência cardíaca aguda?

    Luiz Carlos Santana Passos

    2013-02-01

    Full Text Available Diversos estudos relataram os benefícios dos betabloqueadores (BB para pacientes com insuficiência cardíaca sistólica. No entanto, muitos pacientes hospitalizados em decorrência de insuficiência cardíaca aguda já estão usando os BB e requerem dobutaminas para hipotensão arterial e baixo débito cardíaco. Portanto, deve-se tomar uma decisão a respeito de se o BB deve ser mantido ou até mesmo iniciado nesses casos. O objetivo deste estudo foi determinar se há provas que sustentem a segurança e a eficácia dos BB junto com a dobutamina para pacientes com insuficiência cardíaca aguda descompensada (ICAD. Foi realizada uma pesquisa na literatura de língua inglesa nas bases de dados MEDLINE, ISI Web of Science, Biblioteca Virtual em Saúde, Cochrane Library e o Portal de Revistas Científicas do Capes para identificar estudos relacionados. Literatura adicional foi obtida mediante a análise das respectivas referências encontradas nos artigos identificados. Os resultados esperados incluíram informações sobre o prognóstico (intra-hospitalar e na mortalidade no acompanhamento, número de dias de internação e reinternação, eficácia e segurança (agravamento dos sintomas, choque, intolerância do uso concomitante desses medicamentos em pacientes hospitalizados com ICAD e baixo débito cardíaco. Esta análise incluiu nove estudos. No entanto, não foram encontrados ensaios clínicos randomizados sobre o assunto. A maioria dos estudos inclui baixo número de pacientes, e não foram encontrados estudos que abordem a segurança do uso concomitante desses medicamentos. Os dados resultantes sugerem que uma cuidadosa revisão da literatura não forneceu evidências para o uso sistemático de BB em pacientes com síndrome de baixo débito cardíaco que necessitam de suporte inotrópico com dobutamina.

  15. Avaliação por ressonância magnética de massas cardíacas

    Maria Fernanda Braggion-Santos

    2013-09-01

    Full Text Available FUNDAMENTO: Tumores cardíacos são extremamente raros; no entanto, quando há suspeita clínica, é necessária a correta avaliação diagnóstica, para planejar o tratamento mais adequado. Nesse contexto, a ressonância magnética cardiovascular tem um papel importante, permitindo uma abrangente caracterização de tais lesões. OBJETIVO: Revisar os casos encaminhados a um Serviço de Ressonância Magnética para investigação de massas cardíacas e paracardíacas. Descrever a série de casos positivos, juntamente de uma breve revisão da literatura para cada tipo de lesão e sobre o papel da ressonância magnética cardiovascular em sua avaliação. MÉTODOS: Entre agosto de 2008 e dezembro de 2011, foram revistos todos os casos de pacientes encaminhados a ressonância magnética com suspeita de neoplasia envolvendo o coração. Foram selecionados aqueles com confirmação histopatológica, evolução ou resposta terapêutica compatíveis com a suspeita clínica e achados de imagem. RESULTADOS: Entre os 13 pacientes incluídos neste estudo, oito (62% tiveram confirmação histopatológica. Foram descritas cinco neoplasias benignas (mixomas, rabdomioma e fibromas, cinco neoplasias malignas (sarcoma, linfoma, síndrome de Richter cardíaca e doença metastática e três lesões não neoplásicas (cisto pericárdico, trombo intracardíaco e vegetação infecciosa. CONCLUSÃO: A informação disponível sobre essa questão é escassa. Estudos prospectivos adicionais são necessários para elucidar o papel desses nutrientes no risco cardiovascular de pacientes com diabetes.

  16. Variabilidade da frequência cardíaca em neonatos prematuros e de termo Variabilidad de la frecuencia cardíaca en neonatos prematuros y de término Heart rate variability in preterm and term neonates

    Fabio Augusto Selig

    2011-06-01

    Full Text Available FUNDAMENTO: Várias publicações têm demonstrado a importância do sistema nervoso autônomo por meio dos componentes simpático e parassimpático na gerência da interação entre as diferentes partes do organismo humano. Esses estudos aplicaram técnicas lineares e não lineares (Teoria do Caos de avaliação em diferentes situações, doenças e faixas etárias, tendo como ferramenta a variabilidade da frequência cardíaca (VFC. OBJETIVO: Aplicar os conhecimentos das dinâmicas linear e não linear na avaliação de neonatos prematuros (NPT, analisando sua VFC e comparando com neonatos de termo (NT saudáveis. MÉTODOS: Quarenta e oito neonatos prematuros com diferentes idades gestacionais tiveram seus batimentos cardíacos captados com auxílio do equipamento Polar Advanced S810i e sua VFC obtida pelo registro dos intervalos RR. A VFC foi analisada nos domínios do tempo (SDNN, RMSSD, SD1/SD2, da frequência (VLF, LF, HF e a relação LF/HF e do caos (TAU e sua normalização [TAU(n], Expoente de Lyapunov e Entropia. Os NPT foram comparados com um grupo de 78 NT saudáveis e sem intercorrências perinatais com auxílio do teste não paramétrico de Kruskal-Wallis. RESULTADOS: Detectou-se diferença estatisticamente significante entre os grupos para todas as variáveis estudadas, tanto no domínio do tempo como nos da frequência e do caos. CONCLUSÃO: Neonatos prematuros exibem comportamento menos complexo da variabilidade da frequência cardíaca que neonatos de termo, fato comprovado nos domínios do tempo, da frequência e do caos. O estudo da variabilidade cardíaca nesse grupo pode ser considerado uma ferramenta a mais na avaliação da maturação autonômica e, consequentemente, da progressão para eutrofia.FUNDAMENTO: Varias publicaciones han demostrado la importancia del sistema nervioso autónomo por medio de los componentes simpático y parasimpático en el manejo de la interacción entre las diferentes partes del organismo

  17. Incidência de cirurgia cardíaca em octogenários: estudo retrospectivo Incidencia de cirugía cardíaca en octogenarios: estudio retrospectivo Incidence of cardiac surgery in octogenarian patients: retrospective study

    Luciano Brandão Machado

    2003-09-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O aumento da expectativa de vida faz com que pacientes cada vez mais idosos tenham indicação de tratamento cirúrgico de cardiopatias. Este estudo tem como objetivo avaliar a incidência de pacientes com mais de 80 anos submetidos à cirurgia cardíaca no Instituto do Coração do Hospital das Clínicas da FMUSP, nos últimos 16 anos. MÉTODO: Foram analisados, no período de 1986 a 2001, o número de cirurgias de revascularização do miocárdio (RM e cirurgia valvar (CV e, em cada grupo, o número de cirurgias em pacientes com mais de 80 anos. Os dados foram analisados descritivamente. RESULTADOS: Os dados revelam aumento progressivo do número de octogenários submetidos à cirurgia cardíaca. As cirurgias de revascularização do miocárdio tiveram aumento de 0,13% em 1986 para 3,5% em 2001. As cirurgias valvares aumentaram de 0% em 1986 para 1,44% em 2001, registrando o maior valor de 3,02% em 1999. CONCLUSÕES: Os conhecimentos da fisiopatologia, da senilidade e os avanços no manuseio do trauma cirúrgico estão permitindo estender os recursos da cirurgia cardíaca no grupo de paciente mais idoso. A escolhas da técnica anestésica deve ser criteriosa, bem como a hidratação, a assistência ventilatória e a analgesia pós-operatória, permitindo redução da morbimortalidade neste grupo de maior risco cirúrgico.JUSTIFICATIVA Y OBJETIVOS: El aumento de la expectativa de vida hace con que pacientes cada vez mas edosos tengan indicación de tratamiento quirúrgico de cardiopatias. Este estudio tiene como objetivo evaluar la incidencia de pacientes con más de 80 años sometidos a cirugía cardíaca en el Instituto del Corazón del Hospital de Clínicas de la FMUSP, en los últimos 16 años. MÉTODO: Fueron analizados, en el período de 1986 a 2001, el número de cirugías de revascularización del miocardio (RM y cirugía valvar (CV y, en cada grupo, el número de cirugías en pacientes con más de 80 a

  18. O trabalho da enfermagem no pós-operatório de cirurgia cardíaca: uma revisão integrativa

    Ana Paula Azevedo Santos

    2015-05-01

    Full Text Available Este estudo teve o objetivo de identificar, por meio de produções científicas nacionais e internacionais, os cuidados desenvolvidos pela equipe de enfermagem durante a assistência ao paciente no pósoperatório de cirurgia cardíaca. Trata-se de uma revisão integrativa realizada por meio de busca às bases PubMed, LILACS, CINAHL, SCOPUS e BDENF no período de fevereiro a junho de 2014, com o seguinte questionamento: “Quais os cuidados realizados pela equipe de enfermagem ao paciente no pós-operatório de cirurgia cardíaca?” Utilizou-se como critério de inclusão artigos científicos publicados nos últimos cinco anos, em português, inglês e espanhol, disponíveis na íntegra. Foram selecionados 21 artigos e, mediante a sua leitura criteriosa, foi realizada análise descritiva, possibilitando o agrupamento dos dados em um núcleo temático: cuidando do paciente no pós-operatório de cirurgia cardíaca, que apontou subcategorias: assistindo o paciente após cirurgia cardíaca, gerenciando a dor e a comunicação como ferramenta no cuidado de enfermagem. Os cuidados desenvolvidos no pós-operatório de cirurgia cardíaca demonstram a necessidade de organização do processo de trabalho da equipe de enfermagem bem como competências específicas dos profissionais para atuarem nesse cenário, com intuito de promover um cuidado individualizado e qualificado.

  19. Vitamin and Mineral Supplement Fact Sheets

    ... Tables Online DRI Tool Daily Value (DV) Tables Vitamin and Mineral Supplement Fact Sheets Search the list ... Supplements: Background Information Botanical Dietary Supplements: Background Information Vitamin and Mineral Fact Sheets Botanical Supplement Fact Sheets ...

  20. Neuronal counting and parasympathetic dysfunction in the hearts of chronically Trypanosoma cruzi - infected rats Contagem neuronal e disfunção cardíaca parassimpática em ratos cronicamente infectados pelo Trypanosoma cruzi

    E. Chapadeiro

    1991-10-01

    Full Text Available Ten male Wistar rats, chronically infected with Colombian, São Felipe (12SF and Y strains of Trypanosoma cruzi and ten non-infected control animals were submitted to the bradycardia responsiveness test, an assessment of heart parasympathetic function, after phenylephrine injection. Six chagasic animals showed heart parasympathetic dysfuntion characterized by reduction in the index of bradycardia baroreflex responsiveness, as compared with the control group. Microscopic examination of the atrial heart ganglia of chagasic rats showed ganglionitis, but no statiscally significant reduction in the number of neurons.Dez ratos machos Wistar cronicamente infectados pelas cepas Colombiana, São Felipe (12SF, e Y do Trypanosoma cruzi, foram submetidos, após 8 meses de infecção, juntamente com dez animais controles, ao teste da resposta bradicárdica barorreflexa pela injeção endovenosa de fenilefrina. Seis ratos chagásicos exibiram disfunção cardíaca parassimpática, caracterizada pela depressão do índice da resposta bradicárdica barorreflexa. Embora o estudo histológico dos corações chagásicos mostrasse lesões dos gânglios atriais, a contagem dos neurônios em cortes seriados, não apresentou redução numérica significativa dos mesmos.

  1. Suporte ventilatório na capacidade funcional de pacientes com insuficiência cardíaca: estudo piloto

    Eugênia da Silva Lima

    2011-03-01

    Full Text Available FUNDAMENTO: A insuficiência cardíaca é um importante problema de saúde pública, apresentando a dispneia e a fadiga como principais sintomas clínicos. A utilização do suporte ventilatório não invasivo vem atuando como coadjuvante da reabilitação cardíaca na tentativa de melhorar a capacidade funcional dos pacientes. OBJETIVO: Avaliar a capacidade funcional de pacientes com insuficiência cardíaca submetidos ao suporte ventilatório. MÉTODOS: Foram avaliados dados sociodemográficos, qualidade de vida, FC, pressão arterial (PA, saturação periférica de oxigênio (SpO2, dispneia, concentração de lactato, antes e depois do teste de caminhada de 6 minutos, e a distância percorrida de pacientes com insuficiência cardíaca crônica (ICC, de ambos os sexos, com fração FEVE < 45,0%, randomizados em dois grupos: controle e CPAP (utilizou CPAP 10 cmH2O por 30 minutos. RESULTADOS: Participaram 12 pacientes com ICC classe funcional II e III (NYHA, com média de fração de ejeção do ventrículo esquerdo (FEVE, % de 35,3 ± 8,7, sendo que 8 eram do sexo masculino. A média de idade foi de 46,3 ± 10,3 anos. Na comparação entre os grupos Controle e CPAP, no final do 6º min, foi encontrada diferença significativa nos valores de SpO2% entre os grupos (Controle: 93,6 ± 1,5 % vs CPAP: 96,1 ± 1,8%; p = 0,027, dispneia (Controle: 13,1 ± 1,16 vs CPAP: 11 ± 0,8; p = 0,009, concentração de lactato (Controle: 3,3 ± 0,7 mmol/l vs CPAP: 2,3 ± 0,5 mmol/l; p = 0,025, e distância percorrida no TC6 (Controle: 420,6 ± 73,8 m vs CPAP: 534 ± 89,91 m; p = 0,038. CONCLUSÃO: A realização prévia do CPAP apresentou efeitos benéficos na SpO2, na dispneia, na concentração de lactato, no duplo produto e na distância percorrida no TC6 de pacientes com ICC na realização do TC6.

  2. Os benefícios do recrutamento alveolar nos doentes submetidos a cirurgia cardíaca

    Frias, Ana; Rodrigues, Liliana; Pavia, Patrícia

    2012-01-01

    As complicações pulmonares resultantes da anestesia, trauma cirúrgico e circulação extracorpórea são muito frequentes em doentes submetidos a cirurgia cardíaca, sendo a atelectasia e a hipoxia duas das complicações mais comuns. A atuação do enfermeiro especialista de reabilitação assume um papel preponderante na execução de técnicas para melhorar a mecânica respiratória e reexpansão pulmonar, sendo a mais utilizada a manobra de recrutamento alveolar. Objetivo: conhecer os benefícios do recrut...

  3. Patologia cardíaca: novos biomarcadores associados ao diagnóstico e prognóstico

    Matias, António Pedro Laranjo

    2012-01-01

    Dissertação de mest., Ciências Farmacêuticas, Faculdade de Ciências e Tecnologia, Univ. do Algarve, 2012 As patologias cardíacas afetam cada vez mais indivíduos em todo o mundo, sendo uma das principais causas de debilitação e morte. Podem ter um caráter crónico ou agudo, sendo essencial uma eficaz deteção e acompanhamento da evolução das mesmas. Com este trabalho de revisão bibliográfica pretende-se mostrar a utilidade de substâncias participantes de processos fisiológicos endógenos co...

  4. [ERGOGENIC SPORT SUPPLEMENTS FOR ATHLETES].

    Arieli, Rakefet; Lahav, Yair

    2016-06-01

    Use of performance-enhancing supplements occurs at all levels of sports, from recreational athletes to professional athletes. Although some supplements do enhance athletic performance, many have no proven benefits and have adverse effects. Nutritional supplements are categorized into the following categories: I. Apparently Effective. II. Possibly Effective. III. Too Early To Tell. IV. Apparently Ineffective. This article will review 4 ergogenic supplements which are categorized in the first category--"Apparently Effective"--1) Buffer agents 2) Creatine 3) Caffeine and 4 Nitric Oxide. Given the widespread use of performance enhancing supplements, physicians, and dietitians should be prepared to counsel athletes about their effectiveness, safety and legality. PMID:27544991

  5. Electronic structure and photocatalytic properties of ABi2Ta2O9 (A=Ca, Sr, Ba)

    A new series of layered perovskite photocatalysts, ABi2Ta2O9 (A=Ca, Sr, Ba), were synthesized by the conventional solid-state reaction method and the crystal structures were characterized by powder X-ray diffraction. The results showed that the structure of ABi2Ta2O9 (A=Ca, Sr) is orthorhombic, while that of BaBi2Ta2O9 is tetragonal. First-principles calculations of the electronic band structures and density of states (DOS) revealed that the conduction bands of these photocatalysts are mainly attributable to the Ta 5d+Bi 6p+O 2p orbitals, while their valence bands are composed of hybridization with O 2p+Ta 5d+Bi 6s orbitals. Photocatalytic activities for water splitting were investigated under UV light irradiation and indicated that these photocatalysts are highly active even without co-catalysts. The formation rate of H2 evolution from an aqueous methanol solution is about 2.26 mmol h-1 for the photocatalyst SrBi2Ta2O9, which is much higher than that of CaBi2Ta2O9 and BaBi2Ta2O9. The photocatalytic properties are discussed in close connection with the crystal structure and the electronic structure in details. - Graphical abstract: The valence band of the photocatalysts is consisted of O 2p, Ta 5d and Bi 6s orbitals and the conduction band is from Bi 6p, Ta 5d and O 2p orbitals. Photocatalytic properties of the photocatalyst for H2 evolution without using other co-catalysts from CH3OH/H2O solution and O2 evolution from AgNO3/H2O solution were observed under Hg lamp irradiation

  6. Ansiedade no período pré-operatório de cirurgia cardíaca

    Karyne Kirley Negromonte Gonçalves

    2016-04-01

    Full Text Available RESUMO Objetivo: caracterizar a ansiedade dos pacientes no pré-operatório de cirurgia cardíaca. Método: Foi realizado um estudo de corte transversal no qual 106 pacientes, entre um e cinco dias da data da cirurgia, foram entrevistados utilizando-se um questionário sócio-demográfico próprio e o Inventário de Ansiedade de Beck. Resultados: Os pacientes avaliados se apresentaram em 59,4% (63 na ansiedade mínima e 19,8% (21 na faixa considerada grave, tendo a amostra uma média no nível de ansiedade leve (15,8±19,79. As mulheres tiveram escores (22,13±23,41 significativamente (p=0,003 maiores que os homens (10,76±14,71; assim como os pacientes que já haviam sido submetidos a cirurgia cardíaca prévia (24,4±28,05 X 13,14±15,74. Não houve diferença significativa entre idosos e pacientes adultos mais jovens, nem no tocante as variações de peso, presença de diabetes ou etilismo. Conclusão: Reforça-se a importância do enfermeiro reconhecer a ansiedade pré-operatória e intervir através de estratégias de educação em saúde e visita de enfermagem.

  7. Anticorpos séricos na doença celíaca Celiac disease serum antibodies

    Ceres Concilio ROMALDINI

    1999-12-01

    Full Text Available O diagnóstico acurado da doença celíaca é muito importante porque os pacientes devem aderir a uma dieta sem glúten por toda a vida e diante do maior risco de complicações, como as neoplasias intestinais, que poderá advir do não cumprimento rigoroso da dieta. Nesta revisão são apresentados os novos conceitos referentes às formas de apresentação da doença (ativa, silenciosa, latente e potencial e sua associação com outras enfermidades e são focalizados principalmente o valor e a eficácia da determinação dos anticorpos séricos antigliadina e dos autoanticorpos anti-reticulina, antiendomísio e antitransglutaminase tecidual, no auxílio ao diagnóstico e seguimento da doença celíaca.Accurate diagnosis of celiac disease is important because patients are advised to adhere to a strict gluten-free diet for life. This management is critical to avoid disease complications such as malignancies. In this review the new terminology for the disease clinical features (active, silent, latent and potential celiac disease and the disease association with other conditions are commented. The value and efficacy of the assessment of serum antigliadin antibodies and of antireticulin, antiendomysial and tissue transglutaminase autoantibodies in the diagnosis and follow-up of the celiac disease are particularly evaluated.

  8. Relação entre imagem adrenérgica cardíaca e teste ergométrico na insuficiência cardíaca Relación entre imagen adrenérgica cardíaca y ergometría en la insuficiencia cardíaca Relationship between cardiac adrenergic image and exercise testing in heart failure

    Leandro Rocha Messias

    2011-05-01

    Full Text Available FUNDAMENTO: Na insuficiência cardíaca, o teste ergométrico (TE avalia capacidade funcional, um determinante de prognóstico. A cintilografia com I¹²³ MIBG mostra a ativação simpática cardíaca. OBJETIVO: Avaliar a associação entre as variáveis do TE e as alterações da cintilografia com I¹²³ MIBG. MÉTODOS: Foram submetidos 23 pacientes (FEVE 27%. Esses pacientes realizaram TE, onde foram analisadas: pressão arterial sistólica no pico do esforço (PASP, frequência cardíaca no pico do esforço (FCP, variação da pressão arterial sistólica intraesforço (Δ PAS, reserva cronotrópica e capacidade funcional em METs. Utilizaram-se para a análise estatística, o teste t de Student ou o teste U de Mann-Whitney, o coeficiente de Spearman e o coeficiente de regressão linear. RESULTADOS: A PASP (G1: 181,00 ± 28,01; G2: 153,27 ± 27,71, p = 0,027, a Δ PAS [G1: 64 (47,5-80,5; G2: 36 (25-47 mmHg, p = 0,015], a FCP (G1: 136,91 ± 19,66; G2: 118,45 ± 13,98 bpm, p = 0,018, a reserva cronotrópica (G1: 70,42 ± 17,94; G2: 49,47 ± 14,89%, p = 0,006 e a capacidade funcional [G1: 8,37 (6,47-10,27; G2: 4,42 (2,46-6,38 METs, p = 0,003] foram menores no G2. Houve correlação negativa entre taxa de Washout com PASP (r = -0,505, p = 0,014, Δ PAS (r = -0,493, p = 0,017 e capacidade funcional (r = -0,646, p = 0,001. Após regressão linear, PASP (r = -0,422, p = 0,016 e capacidade funcional (r = -0,804, p = 0,004 foram associadas com taxa de Washout. CONCLUSÃO: Em pacientes com insuficiência cardíaca, PASP e capacidade funcional foram as varáveis mais associadas com a taxa de Washout.FUNDAMENTOS: En la Insuficiencia Cardíaca, la Ergometría (Test Ergométrico - TE evalúa la capacidad funcional, un determinante de pronóstico. El centellograma con I¹²³ MIBG muestra la activación simpática cardíaca. OBJETIVO: Evaluar la asociación entre las variables del TE y las alteraciones del centellograma con I¹²³ MIBG. MÉTODOS: Se

  9. Valor preditivo da frequência cardíaca em repouso do teste ergométrico na mortalidade

    Jaqueline Eilert Fagundes

    2010-12-01

    Full Text Available FUNDAMENTO: A frequência cardíaca em repouso (cuja média está entre 60 e 80 bpm é uma das mais simples variáveis cardiovasculares e tem sido considerada como um preditor de mortalidade cardiovascular e geral. OBJETIVO: Avaliar o valor preditivo da frequência cardíaca em repouso (FCR, antes do teste ergométrico (TE, na mortalidade cardiovascular (CV e geral. MÉTODOS: Estudo de caso-controle, que utilizou informações contidas nos bancos de dados do laboratório de ergometria de um hospital especializado em cardiologia e os registros de óbitos da Secretaria da Saúde em uma cidade do sul do Brasil, de janeiro de 1995 a junho de 2007. Foram analisados 7.055 pacientes, sendo 1.645 (23,3% do grupo caso (óbitos e 5.410 (76,7% do grupo controle (vivos. Foi calculado o ponto de corte da FCR para mortalidade, através da curva ROC e realizada a análise multivariada para as variáveis selecionadas. Os desfechos foram mortalidade CV e geral. RESULTADOS: A incidência de mortalidade CV foi de 674 casos (9,5%; a FCR > 78 bpm foi o ponto de corte. Após ajustado para as variáveis selecionadas, o odds ratio (OR para FCR > 78 bpm foi de 3,5 (IC 95% = 2,9 - 4,2 para mortalidade CV e 3,6 (IC 95% = 3,2 - 4,0 para mortalidade geral. CONCLUSÃO: A FCR > 78 bpm é um preditor independente de mortalidade cardiovascular e geral.

  10. Resveratrol food supplements

    Aschemann-Witzel, Jessica; Grunert, Klaus G

    2015-01-01

    comparing US and Danish respondents, we aimed to identify whether sociodemographic variables, health status, health beliefs and behaviour and interest in food aspects specifically relevant to resveratrol (e.g., naturalness, indulgence, and Mediterranean food) explain favourable attitudes and adoption...... intentions toward resveratrol supplements. Methods: A survey sent to a representative online panel in the United States and Denmark was analysed using linear regression. Results: We find that sociodemographic variables contribute little to explaining favourable attitudes toward and adoption intentions of...... intention. An interest in the indulgence dimension of food explains positive attitudes in the United States and adoption intentions in both countries. Conclusions: The results indicate that potential consumers of resveratrol supplements are identified by their usage of complementary and alternative medicine...

  11. Food Components and Supplements

    Parlesak, Alexandr

    2012-01-01

    The major part of food consists of chemical compounds that can be used for energy production, biological synthesis, or maintenance of metabolic processes by the host. These components are defined as nutrients, and can be categorized into macronutrients (proteins, carbohydrates, triglycerides, and...... alcohol), minerals, and micronutrients. The latter category comprises 13 vitamins and a hand full of trace elements. Many micronutrients are used as food supplements and are ingested at doses exceeding the amounts that can be consumed along with food by a factor of 10–100. Both macro- and micronutrients...... supplements and contaminants can compete directly with drug oxidation, induce or suppress the expression of xenobiotic-metabolizing enzymes, change the bioavailability of drugs, and, in the case of live bacteria, bring in their own xenobiotic metabolism, including cytochrome P450 (CYP) activity. In numerous...

  12. Effective Nutritional Supplement Combinations

    Cooke, Matt; Cribb, Paul J.

    Few supplement combinations that are marketed to athletes are supported by scientific evidence of their effectiveness. Quite often, under the rigor of scientific investigation, the patented combination fails to provide any greater benefit than a group given the active (generic) ingredient. The focus of this chapter is supplement combinations and dosing strategies that are effective at promoting an acute physiological response that may improve/enhance exercise performance or influence chronic adaptations desired from training. In recent years, there has been a particular focus on two nutritional ergogenic aids—creatine monohydrate and protein/amino acids—in combination with specific nutrients in an effort to augment or add to their already established independent ergogenic effects. These combinations and others are discussed in this chapter.

  13. The financial burden of medical spending: estimates and implications for evaluating the impact of ACA reforms.

    Abramowitz, Joelle; O'Hara, Brett

    2015-04-01

    This article uses the 2013 Current Population Survey Annual Social and Economic Supplement to estimate the financial burden of medical out-of-pocket costs by comparing medical out-of-pocket expenditures to income. This measure is important for evaluating the magnitude of burden, better understanding who bears it, and establishing a baseline to assess the impact of the Patient Protection and Affordable Care Act. We examine the distribution of burden and the incidence of high burden across all families and by individuals' health insurance status and demographic and socioeconomic characteristics. We look more closely at one group vulnerable to having high burden: those younger than age 65 with incomes between 138% and 200% of the federal poverty line. We find that 18.5% of these individuals have incomes below the threshold of expansion Medicaid eligibility after accounting for non-over-the-counter medical expenses and examine the characteristics associated with being classified below this threshold. PMID:25524865

  14. Perfil epidemiológico, clínico e terapêutico da insuficiência cardíaca em hospital terciário Perfil epidemiológico, clínico y terapéutico de la insuficiencia cardíaca en hospital terciario Epidemiological, clinical e therapeutic profile of heart failure in a tertiary hospital

    Patrícia Resende Nogueira; Salvador Rassi; Krislainy de Sousa Corrêa

    2010-01-01

    FUNDAMENTO: A insuficiência cardíaca é uma síndrome complexa com múltiplos fatores de risco envolvidos em sua gênese, tornando difícil a prevenção e o manejo. OBJETIVO: Identificar as principais etiologias e os fatores de risco na insuficiência cardíaca; comparar características clínicas e demográficas dos pacientes conforme a etiologia; analisar se o tratamento utilizado está de acordo com o preconizado pelas diretrizes brasileiras. MÉTODOS: Estudo retrospectivo, descritivo e observacional r...

  15. Growth capacity of thermotolerant campylobacters in culture media supplemented with pig and cow blood

    Álvaro Tresierra-Ayala; Manuel Navas; Josué Flores; Ramsés Perea; Juan Huanaquiri; María Bendayán; Heriberto Fernández

    2010-01-01

    In this work 60 thermotolerant Campylobacter strains (37 C. jejuni and 23 C. coli) isolated from the cows, pigs, chickens and ducks (15 strains of each type of animal) were used to establish their growth capacity on media containing cow or swine blood as potential substitutes of sheep or horse blood. The growth capacity was assessed by viable counts on cow and swine blood media, using the modified Miles and Misra method. Campylobacter strains showed better growth in the media supplemented wit...

  16. Miniesternotomia: um acesso seguro para a cirurgia cardíaca

    Leonardo Andrade MULINARI

    1997-10-01

    Full Text Available Atualmente, na constante busca de minimizar o tempo de intemação hospitalar e melhorar a recuperação no pós-operatório, várias altemativas cirúrgicas têm sido aventadas. Iniciamos o uso da estemotomia parcial como acesso para diversos tipos de operações cardíacas. O presente trabalho tem como objetivo apresentar a evolução hospitalar dos pacientes operados através desta técnica. No período de novembro de 1996 a março de 1997, estudamos 51 pacientes operados através da esternotomia parcial. A idade média foi de 46,8 anos, sendo 26 pacientes do sexo feminino. Os procedimentos mais realizados foram o tratamento cirúrgico valvar e as revascularizações miocárdicas. O acesso utilizado para os pacientes com lesões valvares foi a esternotomia parcial em "T" invertido no segmento superior do esterno; para outras lesões, uma esternotomia em "T" no segmento inferior e, pela dificuldade técnica imposta nas re-operações e nos procedimentos múltiplos, utilizou-se uma terceira variação, que foi a esternotomia parcial em "H" deitado, estendendo-se no corpo esternal do primeiro ao quarto espaço intercostal. O comprimento médio da incisão de pele foi de 9,9 cm. Foram realizadas 19 incisões em "T", 17 em "T" invertido e 15 em "H" deitado. O tempo médio de ventilação mecânica foi de 2,8 horas, de permanência na UTI de 31,5 horas e de internação hospitalar de 5,9 dias. Não houve complicação diretamente relacionada com o acesso e em apenas 1 caso foi necessária a conversão para a esternotomia total. Analisando a evolução destes 51 pacientes, pudemos concluir que a esternotomia parcial é um acesso seguro para o tratamento cirúrgico de diversas cardiopatias, isoladas, associadas ou re-operações. Traz um resultado estético favorável e facilita a recuperação no pós- operatório, devendo fazer parte do repertório de todo o cirurgião cardiovascular.Recently, in the constant search for shortening hospital stay and

  17. Construção e Validação do Questionário de Conhecimentos para Pacientes com Insuficiência Cardíaca

    Christiani Decker Batista Bonin

    2014-04-01

    Full Text Available Fundamento: A ausência de instrumentos capazes de mensurar o nível de conhecimento de pacientes com insuficiência cardíaca sobre sua própria síndrome, participantes de programas de reabilitação, demonstra a carência de recomendações específicas a respeito da quantidade ou do conteúdo de informações necessárias. Objetivo: Construir e validar um questionário para avaliar o conhecimento sobre sua condição de pacientes portadores de insuficiência cardíaca participantes de programas de reabilitação cardíaca. Métodos: O instrumento foi construído com base no questionário de conhecimento para doença coronariana e aplicado em 96 pacientes com insuficiência cardíaca, com média de idade de 60,22 ± 11,6 anos, 64% homens. A reprodutibilidade foi obtida por meio do coeficiente de correlação intraclasse, utilizando-se as situações do método de teste-reteste. A consistência interna foi obtida pelo alfa de Cronbach e a validade do construto, pela análise fatorial exploratória. Resultados: A versão final do instrumento apresentou 19 questões dispostas em dez áreas de importância para a educação do paciente. O instrumento proposto apresentou um índice de clareza de 8,94 ± 0,83. O valor do coeficiente de correlação intraclasse foi de 0,856 e do alfa de Cronbach, 0,749. A análise fatorial revelou cinco fatores associados às áreas de conhecimento. Quando os escores finais foram comparados com as características da população, verificou-se que baixa escolaridade e baixa renda estão significativamente associadas a baixos escores de conhecimento. Conclusão: O instrumento possui índice de clareza satisfatório e de validade adequado, podendo ser utilizado para avaliar o conhecimento de pacientes com insuficiência cardíaca participantes de programas de reabilitação cardíaca.

  18. Limiar ventilatório e variabilidade da freqüência cardíaca em adolescentes Umbral ventilatorio y variabilidad de la frecuencia cardíaca en los adolescentes Ventilatory threshold and heart rate variability in adolescents

    Antônio Fernando Brunetto

    2005-02-01

    Full Text Available As análises da concentração sanguínea de lactato e das trocas gasosas respiratórias são métodos tradicionalmente empregados para identificar a transição de produção de energia pelo metabolismo muscular. No entanto, mais recentemente, vem sendo sugerido método alternativo mediante análise da variabilidade da freqüência cardíaca. Pretendeu-se, com o presente estudo, estabelecer comparações entre o limiar de variabilidade da freqüência cardíaca (LiVFC e o primeiro limiar ventilatório (LV1, em uma amostra de adolescentes. Para tanto, foram submetidos a teste de esforço físico de carga máxima em esteira ergométrica 41 sujeitos (22 rapazes e 19 moças com idades entre 15 e 18 anos. O LV1 foi identificado mediante o equivalente ventilatório de oxigênio envolvendo recursos de ergoespirometria. A variabilidade da freqüência cardíaca foi analisada por intermédio dos intervalos R-R, através da plotagem de Poincaré, que oferece informações quanto ao desvio-padrão da variabilidade instantânea batimento-a-batimento (SD1, ao desvio-padrão a longo prazo de intervalos R-R contínuos (SD2 e à razão SD1/SD2. O LiVFC foi identificado pelo SD1 de acordo com três critérios: (1 diferenças entre o SD1 de dois estágios consecutivos menor que 1ms; (2 SD1 menor que 3ms; e (3 ocorrência de ambos os critérios em conjunto. Mediante análise dos resultados verificou-se que os intervalos R-R e SD2 diminuíram progressivamente a cada intervalo de 10% do VO2pico até o final do teste de esforço físico (0,05 El análisis de la concentración sanguínea de lactato y de los cambios gaseosos respiratorios son métodos tradicionalmente empleados para identificar la transición de la producción de energía por el metabolismo muscular. No en tanto, mas recientemente viene siendo sugerido como método alternativo mediante el análisis de la variabilidad de la frecuencia cardíaca. Se pretende con el presente estudio establecer

  19. Frequência Cardíaca de Recuperação no Primeiro Minuto no Teste de Caminhada de Seis Minutos em Pacientes com Insuficiência Cardíaca

    Sabrina Lindemberg

    2014-03-01

    Full Text Available Fundamento: A frequência cardíaca de recuperação no primeiro minuto (FCR1 é um preditor de mortalidade na insuficiência cardíaca (IC, mas seu prognóstico não foi avaliado no teste de caminhada de seis minutos (TC6M nesses pacientes. Objetivo: Esse estudo teve como objetivo determinar a FCR1 no TC6M em pacientes com IC e sua correlação com a distância percorrida em seis minutos (DP6M. Métodos: Protocolo controlado, transversal, com 161 indivíduos, 126 pacientes com IC sistólica estável, divididos em dois grupos (G1 e G2, que receberam ou não β-bloqueador e 35 voluntários no grupo controle (G3 que tiveram a FCR1 registrada no TC6M. Resultados: A FCR1 e a DP6M foram significativamente diferentes nos três grupos. Os valores médios de FCR1 e DP6M foram: FCR1 = 12 ± 14 bpm G1, 18 ± 16 bpm G2 e 21 ± 13 bpm G3; DP6M = 423 ± 102 m G1, G2 396 ± 101 m e 484 ± 96 m G3 (p < 0,05. Os resultados demonstraram uma correlação entre FCR1 e DP6M no G1 (r = 0,3, p = 0,04 e G3 (r = 0,4, p = 0,03, mas não em G2 (r = 0,12, p = 0,48. Conclusão: A resposta da FCR1 foi atenuada em pacientes em uso de βB e mostrou correlação com o TC6M, refletindo uma melhor tolerância ao exercício. A FCR1 após a DP6M parece representar uma alternativa quando os testes de esforço na esteira não são tolerados.

  20. Geobacteraceae strains and methods

    Lovley, Derek R.; Nevin, Kelly P.; Yi, Hana

    2015-07-07

    Embodiments of the present invention provide a method of producing genetically modified strains of electricigenic microbes that are specifically adapted for the production of electrical current in microbial fuel cells, as well as strains produced by such methods and fuel cells using such strains. In preferred embodiments, the present invention provides genetically modified strains of Geobacter sulfurreducens and methods of using such strains.

  1. Bodybuilding supplementation and tooth decay.

    Ali, M S; Batley, H; Ahmed, F

    2015-07-10

    Supplementation is a key component in bodybuilding and is increasingly being used by amateur weight lifters and enthusiasts to build their ideal bodies. Bodybuilding supplements are advertised to provide nutrients needed to help optimise muscle building but they can contain high amounts of sugar. Supplement users are consuming these products, while not being aware of their high sugar content, putting them at a higher risk of developing dental caries. It is important for dental professionals to recognise the increased risk for supplement users and to raise awareness, provide appropriate preventative advice and be knowledgeable of alternative products to help bodybuilders reach their goals, without increasing the risk of dental caries. PMID:26159983

  2. El aumento del riesgo de mortalidad en la cirugía cardíaca. ¿Realmente estamos operando pacientes con incremento del riesgo?

    Raúl A. Borracci; Miguel Rubio

    2006-01-01

    Aunque varios estudios parecen demostrar el aumento en el tiempo del riesgo quirúrgico de los candidatos a cirugía cardíaca, la mayoría de las comunicaciones se basan en su incremento promedio, sin analizar la verdadera distribución por grupos de riesgo. Con el objetivo de evaluar si en la actualidad existe un aumento del riesgo de mortalidad en la cirugía cardíaca en nuestro medio respecto del riesgo de una década atrás, basándonos no sólo en la variación promedio, sino también en la dis...

  3. Importancia de la cirugía aorto-ilíaca previa o simultánea en la evolución del trasplante renal

    Martínez Carnovale, Lucía Inés

    2011-01-01

    La malaltia renal crònica terminal, el tractament substitutiu d'elecció és el trasplantament renal, és un problema de salut pública mundial en augment. L'envelliment de la població i la major prevalença de diabetis i hipertensió arterial en aquests pacients, s'associa a una major incidència de malaltia aorto-ilíaca i possible fracàs del ronyó trasplantat. En aquest treball es va analitzar l'evolució del filtrat glomerular en pacients trasplantats renals amb patologia aorto-ilíaca que van requ...

  4. Optimización de un modelo de soporte para bioprótesis valvular cardíaca mediante métodos numéricos

    Diego Marín

    2001-04-01

    Full Text Available Las bioprótesis valvulares cardíacas (BVC son sometidas a diferentes
    requerimientos mecánicos para cumplir con la actividad hemodinámica cardíaca. La experiencia demuestra que el soporte de
    la bioprótesis (ASBVC ejerce un importante papel en la operatividad
    del implante, relacionado con la distribución de tensiones en las valvas biológicas y la adecuada coaptación. Para evaluar el comportamiento del ASBVC es necesario analizar los esfuerzos y tensión necesarios para alcanzar la fatiga del dispositivo, así como calcular la concentración esfuerzo-deformación durante su funcionamiento.

  5. Estetoscópio digital como ferramenta inovadora no ensino da ausculta cardíaca Digital stethoscope as an innovative tool on the teaching of auscultatory skills

    Claudio Tinoco Mesquita; Jader Costa dos Reis; Luciana Silveira Simões; Eduardo Cardoso de Moura; Gustavo Amarante Rodrigues; Carolina Cunto de Athayde; Hugo Lima Machado; Pedro Gemal Lanzieri

    2013-01-01

    O exame físico cardiovascular, em particular a ausculta cardíaca, é uma das habilidades clínicas mais difíceis para os alunos durante seu treinamento médico. Estudos sugerem que o uso de tecnologias, como o estetoscópio digital, aumente a acurácia do exame clínico, entretanto, seu impacto no ensino da propedêutica da ausculta cardíaca em alunos de graduação de Medicina não é conhecido. O objetivo é demonstrar a utilidade do estetoscópio digital, em comparação com métodos tradicionais, como in...

  6. Dosagem única de troponina cardíaca T prediz risco adverso na insuficiência cardíaca descompensada Dosificación única de troponina cardíaca T predice riesgo adverso en la insuficiencia cardiaca descompensada Single cardiac troponin T measurement predicts risk for adverse outcome in decompensated heart failure

    Manoel D. C. Oliveira

    2010-04-01

    Full Text Available FUNDAMENTO: O aumento discreto de troponina cardíaca no sangue de pacientes com insuficiência cardíaca (IC sugere que miofibrilas são degradadas no miocárdio e liberadas na circulação, refletindo um processo contínuo e progressivo de lesão do aparato contrátil. OBJETIVO: Correlacionar o nível sérico da troponina cardíaca-T (TnTc à admissão hospitalar de pacientes com IC descompensada e o prognóstico. MÉTODOS: Foram incluídos 79 pacientes consecutivos, internados por IC descompensada, com FEVE 2,5 mg%, insuficiência hepática ou doenças neuromusculares. RESULTADOS: Detectou-se TnTc elevada (>0,02 ng/ml em 37 pacientes (46,84%. A mortalidade global foi de 35,4%. Nos grupos TnTc elevada e TnTc baixa (FUNDAMENTO: El aumento discreto de troponina cardíaca en la sangre de pacientes con insuficiencia cardiaca (IC sugiere que miofibrillas se degraden en el miocardio y se liberen en la circulación, lo que refleja un proceso continuo y progresivo de lesión del aparato contráctil. OBJETIVO: Correlacionar el nivel sérico de la troponina cardíaca-T (TnTc al ingreso hospitalario de pacientes con IC descompensada y el pronóstico. MÉTODOS: Se incluyó a 79 pacientes consecutivos, internados por IC descompensada, con FEVI 2,5 mg%, insuficiencia hepática o enfermedades neuromusculares. RESULTADOS: Se detectó TnTc elevada (> 0,02 ng/ml en 37 pacientes (46,84%. La mortalidad global fue del 35,4%. En los grupos TnTc elevada y TnTc baja (BACKGROUND: The slight increase in cardiac troponin in the blood of patients with heart failure (HF suggests that myofibrils are degraded in the myocardium and released in the circulation, reflecting a continuous and progressive injury process in the contractile system. OBJECTIVE: To correlate the serum levels of cardiac troponin T (TnT at the hospital admission of patients with decompensated HF and prognosis. METHODS: A total of 79 consecutive patients, hospitalized due to decompensated HF, with LVEF 2

  7. Mead production: selection and characterization assays of Saccharomyces cerevisiae strains.

    Pereira, Ana Paula; Dias, Teresa; Andrade, João; Ramalhosa, Elsa; Estevinho, Letícia M

    2009-08-01

    Mead is a traditional drink, which results from the alcoholic fermentation of diluted honey carried out by yeasts. However, when it is produced in a homemade way, mead producers find several problems, namely, the lack of uniformity in the final product, delayed and arrested fermentations, and the production of "off-flavours" by the yeasts. These problems are usually associated with the inability of yeast strains to respond and adapt to unfavourable and stressful growth conditions. The main objectives of this work were to evaluate the capacity of Saccharomyces cerevisiae strains, isolated from honey of the Trás-os-Montes (Northeast Portugal), to produce mead. Five strains from honey, as well as one laboratory strain and one commercial wine strain, were evaluated in terms of their fermentation performance under ethanol, sulphur dioxide and osmotic stress. All the strains showed similar behaviour in these conditions. Two yeasts strains isolated from honey and the commercial wine strain were further tested for mead production, using two different honey (a dark and a light honey), enriched with two supplements (one commercial and one developed by the research team), as fermentation media. The results obtained in this work show that S. cerevisiae strains isolated from honey, are appropriate for mead production. However it is of extreme importance to take into account the characteristics of the honey, and supplements used in the fermentation medium formulation, in order to achieve the best results in mead production. PMID:19481129

  8. Tissue-specific root ion profiling reveals essential roles of the CAX and ACA calcium transport systems in response to hypoxia in Arabidopsis.

    Wang, Feifei; Chen, Zhong-Hua; Liu, Xiaohui; Colmer, Timothy David; Zhou, Meixue; Shabala, Sergey

    2016-06-01

    Waterlogging is a major abiotic stress that limits the growth of plants. The crucial role of Ca(2+) as a second messenger in response to abiotic and biotic stimuli has been widely recognized in plants. However, the physiological and molecular mechanisms of Ca(2+) distribution within specific cell types in different root zones under hypoxia is poorly understood. In this work, whole-plant physiological and tissue-specific Ca(2+) changes were studied using several ACA (Ca(2+)-ATPase) and CAX (Ca(2+)/proton exchanger) knock-out Arabidopsis mutants subjected to waterlogging treatment. In the wild-type (WT) plants, several days of hypoxia decreased the expression of ACA8, CAX4, and CAX11 by 33% and 50% compared with the control. The hypoxic treatment also resulted in an up to 11-fold tissue-dependent increase in Ca(2+) accumulation in root tissues as revealed by confocal microscopy. The increase was much higher in stelar cells in the mature zone of Arabidopsis mutants with loss of function for ACA8, ACA11, CAX4, and CAX11 In addition, a significantly increased Ca(2+) concentration was found in the cytosol of stelar cells in the mature zone after hypoxic treatment. Three weeks of waterlogging resulted in dramatic loss of shoot biomass in cax11 plants (67% loss in shoot dry weight), while in the WT and other transport mutants this decline was only 14-22%. These results were also consistent with a decline in leaf chlorophyll fluorescence (F v/F m). It is suggested that CAX11 plays a key role in maintaining cytosolic Ca(2+) homeostasis and/or signalling in root cells under hypoxic conditions. PMID:26889007

  9. Plate-forme Magicien d'Oz pour l'\\'etude de l'apport des ACAs \\`a l'interaction

    Simonin, Jérôme; Hategan, Marius; Carbonell, Noëlle

    2007-01-01

    In order to evaluate the contribution of Embodied (Animated) Conversational Agents (ECAs) to the effectiveness and usability of human-computer interaction, we developed a software platform meant to collect usage data. This platform, which implements the wizard of Oz paradigm, makes it possible to simulate user interfaces integrating ACAs for any Windows software application. It can also save and "replay" a rich interaction trace including user and system events, screen captures, users' speech...

  10. MicroRNAs: um novo paradigma no tratamento e diagnóstico da insuficiência cardíaca?

    Vagner Oliveira-Carvalho

    2012-04-01

    Full Text Available MicroRNAs (miRNAs são um grupo recém-descoberto de pequenos RNAs, não codificantes, que representam uma das áreas mais estimulantes da ciência médica moderna por modularem uma enorme e complexa rede regulatória da expressão dos genes.Recentemente, linhas de evidências sugerem que os miRNAs desempenham um papel crucial na patogênese da insuficiência cardíaca. Alguns miRNAs altamente expressos no coração como o miR-1, miR-133 e miR-208 estão fortemente associados ao desenvolvimento da hipertrofia cardíaca, enquanto o exato papel de miR-21 no sistema cardiovascular permanece controverso. Os níveis séricos de miRNAs circulantes como o miR-423-5p estão sendo avaliados como potenciais biomarcadores no diagnóstico e prognóstico da insuficiência cardíaca.Por outro lado, a manipulação dos níveis de miRNAs usando técnicas como os mimetizadores de miRNAs (miRmimics e miRNAs antagônicos(antagomiRs está tornando cada vez mais evidente o enorme potencial dos miRNAs como promissoras estratégias terapêutica sna insuficiência cardíaca.

  11. Avaliação eletrofisiológica cardíaca em pacientes com sarcoidose

    Jefferson Curimbaba

    2011-04-01

    Full Text Available FUNDAMENTO: Sarcoidose é uma doença granulomatosa multissistêmica de origem desconhecida que pode causar morte súbita. OBJETIVO: Avaliação eletrofisiológica de pacientes com sarcoidose com suspeita de comprometimento cardíaco. MÉTODOS: Foram estudados 22 pacientes com média de idade de 55,32 ±13,13 anos, com diagnóstico de sarcoidose e suspeita de comprometimento cardíaco. Foram submetidos à avaliação clínica, exames laboratoriais, eletrocardiograma, ecocardiograma, Holter de 24h, cintilografia com gálio ou tecnécio e estudo eletrofisiológico. Em casos selecionados foi realizada tomografia por emissão de pósitrons ou ressonância magnética. Os pacientes foram seguidos ambulatoriamente com consultas trimestrais. RESULTADOS: Comprometimento cardíaco foi comprovado em quatro (18,2% pacientes. Extrassístoles ventriculares com densidade > 100/24h foram documentadas no Holter de 24h em 12 (54,5 % pacientes. O estudo eletrofisiológico revelou aumento do intervalo HV em sete (31,8% e ponto de Wenckebach aumentado em quatro (18,2% pacientes. Houve indução de fibrilação atrial em sete (31,8% e de taquicardia ventricular sustentada em um (4,5%. Nos quatro pacientes com sarcoidose cardíaca confirmada, extrassístoles ventriculares, com densidade > 100/24h foram documentadas em todos, dois apresentavam intervalo HV prolongado e fibrilação atrial foi induzida em dois. Taquicardia ventricular sustentada não foi induzida em nenhum desses pacientes. Após período médio de acompanhamento de 20,9 ± 15,7 meses, um paciente com sarcoidose cardíaca apresentou morte súbita. CONCLUSÃO: Pacientes com sarcoidose e suspeita de envolvimento cardíaco apresentam alta prevalência de EVs e distúrbios do sistema de condução.

  12. Recomendações da sociedade brasileira de arritmias cardíacas para serviços de holter

    Adalberto Lorga Filho

    2013-08-01

    Full Text Available FUNDAMENTOS: Inúmeros indicadores são utilizados para assegurar a qualidade de um serviço; entretanto, a competência médica e o adequado fluxo de realização de um procedimento são determinantes da qualidade final. Nesse contexto, a Sociedade Brasileira de Arritmias Cardíacas pretende recomendar parâmetros mínimos necessários para garantir a excelência dos serviços de monitorização eletrocardiográfica ambulatorial. OBJETIVOS: Recomendar competências médicas mínimas e as informações necessárias para emissão do laudo de Holter. MÉTODOS: O documento foi fundamentado no conceito de medicina baseada em evidência, e nas circunstâncias em que a evidência não estava disponível a opinião de uma comissão de redação foi utilizada para a formulação da recomendação. Essa comissão foi formada por profissionais que apresentam vivência nas dificuldades do método e gestão na prestação de serviços nessa área. RESULTADOS: O profissional responsável pela análise de Holter deve conhecer as patologias cardiovasculares e ter formação consistente em eletrocardiografia, incluindo arritmias cardíacas e seus diagnósticos diferenciais. O laudo deve ser redigido de forma clara e objetiva. Os parâmetros mínimos que devem constar no laudo incluem as estatísticas do exame, assim como quantificação e análise dos distúrbios do ritmo observados durante a monitorização. CONCLUSÃO: A monitorização eletrocardiográfica ambulatorial deve ser realizada por profissionais com vivência em análise eletrocardiográfica e o laudo deve conter os parâmetros mínimos mencionados nesse documento.

  13. Muscle strain (image)

    A muscle strain is the stretching or tearing of muscle fibers. A muscle strain can be caused by sports, exercise, a ... something that is too heavy. Symptoms of a muscle strain include pain, tightness, swelling, tenderness, and the ...

  14. Muscle strain treatment

    Treatment - muscle strain ... Question: How do you treat a muscle strain ? Answer: Rest the strained muscle and apply ice for the first few days after the injury. Anti-inflammatory medicines or acetaminophen ( ...

  15. Efeitos do tartarato de metoprolol em pacientes portadores de insuficiência cardíaca Effects of metoprolol tartrate therapy in patients with heart failure

    José Albuquerque de Figueiredo Neto

    2006-09-01

    Full Text Available OBJETIVO: Estudar os efeitos do tartarato de metoprolol em pacientes portadores de insuficiência cardíaca. MÉTODOS: Foram avaliados em estudo prospectivo, 50 pacientes (36 homens com insuficiência cardíaca, classe funcional II a IV, com 52±14,8 anos, e fração de ejeção do ventrículo esquerdo (FEVE 0,05. A freqüência cardíaca apresentou redução de 78,84±batimentos por minuto para 67,48±1,86 batimentos por minuto (pOBJECTIVE: To study the effects of metoprolol tartrate therapy in patients with heart failure. METHODS: Fifty patients (36 males aged 52±14.8 yrs, with functional class II to IV heart failure (HF and left ventricular ejection fraction (LVFE 0.05. Cardiac frequency decreased from 78.84±1.68 to 67.48±1.86 b.p.m. (p<0.001. CONCLUSION: The adding of metoprolol tartrate to the usual heart failure therapy is followed by an increase of ejection fraction, functional class improvement, and decrease of ventricular diameters and cardiac frequency. These results suggest anti-remodeling effects in patients with HF who utilize metoprolol tartrate in addition to the usual therapy.

  16. Nutritional Supplements for Endurance Athletes

    Rasmussen, Christopher J.

    Athletes engaged in heavy endurance training often seek additional nutritional strategies to help maximize performance. Specific nutritional supplements exist to combat certain factors that limit performance beginning with a sound everyday diet. Research has further demonstrated that safe, effective, legal supplements are in fact available for today's endurance athletes. Several of these supplements are marketed not only to aid performance but also to combat the immunosuppressive effects of intense endurance training. It is imperative for each athlete to research the legality of certain supplements for their specific sport or event. Once the legality has been established, it is often up to each individual athlete to decipher the ethics involved with ingesting nutritional supplements with the sole intent of improving performance.

  17. Regional Assessment of Supplementation Project

    The Fish and Wildlife Program of the Northwest Power Planning Council (NPPC) prescribes several approaches to achieve its goal of doubling the salmon and steelhead runs of the Columbia River. Among those approaches are habitat restoration, improvements in adult and juvenile passage at dams and artificial propagation. Supplementation will be a major part of the new hatchery programs. The purpose of the Regional Assessment of Supplementation Project (RASP) is to provide an overview of ongoing and planned supplementation activities, to construct a conceptual framework and model for evaluating the potential benefits and risks of supplementation and to develop a plan for better regional coordination of research and monitoring and evaluation of supplementation. RASP has completed its first year of work. Progress toward meeting the first year's objectives and recommendations for future tasks are contained in this report

  18. Intervención psicológica en cirugía cardíaca

    Yalilis Castillero Amador

    2007-01-01

    Full Text Available La cirugía mayor y en particular la cirugía cardiovascularson una fuente potencial de estrés. Este artículo muestra la efectividad de la preparación psicológica en los pacientes sometidos a cirugía cardíaca. A través de una revisión de la literatura consideramos el impacto, tanto físico como psicológico, que tiene el padecer una enfermedad cardiovascular y el ser sometido a una cirugía del corazón.El corazón es un órgano al que se le atribuye un carácter de primacía en relación con los otros, por lo que existe un gran número de respuestas emocionalesante cualquier padecimiento relacionado con el mismo. Se puntualizan los beneficios de la intervenciónpsicológica en la cirugía y se propone un programa que facilite un adecuado afrontamiento y recuperación en la cirugía cardiovascular.

  19. Insuficiência cardíaca: expressões do conhecimento das pessoas sobre a doença

    Maria Teresa Silva de Freitas

    2013-08-01

    Full Text Available Pesquisa de natureza qualitativa que teve como objetivos caracterizar pessoas com Insuficiência Cardíaca (IC segundo perfil sócio-demográfico, de saúde e de tratamento e analisar o conhecimento sobre a doença e tratamento. Foram entrevistados 42 pacientes com IC, em um hospital de cardiologia de São Paulo, foi utilizado questionário semiestruturado e análise de conteúdo dos dados. Predominou sexo masculino, idade maior que 45 anos, classe funcional II, comorbidades associadas e tratamento farmacológico. Da análise de conteúdo emergiram as categorias: conhecimento sobre a doença e conhecimento do tratamento. O conhecimento é ilustrativo, diagnóstico e explicativo, sendo atribuídos muitos significados à doença. A maioria desconhece nome, dose e frequência de uso dos medicamentos. O tratamento não farmacológico está relacionado às orientações dos profissionais de saúde sobre alimentação, sal e ingesta hídrica. Os resultados abrem perspectivas para intervenções educativas sistematizadas que possam contribuir para um melhor enfrentamento e manejo da doença.

  20. Muerte súbita cardíaca en mujer joven Sudden cardiac death in young woman

    M. Salguero Villadiego

    2003-10-01

    Full Text Available Presentamos un caso de muerte súbita cardíaca en una mujer joven sin patología arteriosclerótica en las arterias coronarias. En el miocardio y el aparato valvular no se preciaban alteraciones morfológicas. En la arteria coronaria desce ndente anterior se advierte un hematoma disecante que produce una oclusión completa de la luz vascular sin que existan evidencias morfológicas de degeneración quística de la media. Diagnóstico: Disección espontánea de la arteria coronaria descendente anterior.We present a case of sudden cardiac death in a young woman without arteriosclerotic pathology in the coronary arteries. In the myocardium and the valvular apparatus morphologic alterations were not appreciated. In the anterior coronary descending artery there is noticeable a dissecting hematoma that produces a complete occlusion of the vascular light without any morphologic evidence of cystic degeneracy of the tunica media. iagnosis: spontaneous dissection of the anterior coronary descending artery.

  1. Synthesis, crystal structure, and magnetism of A2Co12As7 (A=Ca, Y, Ce-Yb)

    Tan, Xiaoyan; Ovidiu Garlea, V.; Chai, Ping; Geondzhian, Andrey Y.; Yaroslavtsev, Alexander A.; Xin, Yan; Menushenkov, Alexey P.; Chernikov, Roman V.; Shatruk, Michael

    2016-04-01

    Ternary intermetallics, A2Co12As7 (A=Ca, Y, Ce-Yb), have been synthesized by annealing mixtures of elements in molten Bi at 1223 K. The materials obtained crystallize in the P63/m variant of the Zr2Fe12P7 structure type. The unit cell volume shows a monotonic decrease with the increasing atomic number of the rare-earth metal, with the exception of Ce-, Eu-, and Yb-containing compounds. An examination of these outliers with X-ray absorption near edge structures (XANES) spectroscopy revealed mixed valence of Ce, Eu, and Yb, with the average oxidation states of +3.20(1), +2.47(5), and +2.91(1), respectively, at room temperature. Magnetic behavior of A2Co12As7 is generally characterized by ferromagnetic ordering of Co 3d moments at 100-140 K, followed by low-temperature ordering of rare-earth 4f moments. The 3d-4f magnetic coupling changes from antiferromagnetic for A=Pr-Sm to ferromagnetic for A=Ce and Eu-Yb. Polarized neutron scattering experiments were performed to support the postulated ferro- and ferrimagnetic ground states for Ce2Co12As7 and Nd2Co12As7, respectively.

  2. Polimorfismo G894T da óxido nítrico-sintetase endotelial e o prognóstico na insuficiência cardíaca

    Oziel Marcio Araujo Tardin

    2013-10-01

    Full Text Available FUNDAMENTO: Estudos prévios avaliaram o papel do polimorfismo genético da enzima óxido nítrico-sintetase endotelial sobre o prognóstico na insuficiência cardíaca. Entretanto, faltam estudos relacionando o G894T e a insuficiência cardíaca na população brasileira. OBJETIVO: Avaliar a associação do G894T com o prognóstico de amostra de pacientes brasileiros com insuficiência cardíaca. MÉTODOS: Coorte com 145 pacientes com insuficiência cardíaca sistólica, num segmento de 40 meses (média = 22 meses, em dois hospitais universitários do Estado do Rio de Janeiro. Foi avaliada a relação do G894T com os desfechos: remodelamento reverso; melhora da classe funcional (NYHA; taxas de mortalidade e hospitalização. Os diâmetros do átrio e ventrículo esquerdos e a fração de ejeção do ventrículo esquerdo foram medidos na admissão e após 6 meses, para avaliação do remodelamento reverso. A melhora na classe funcional foi avaliada após 6 meses e as taxas de mortalidade e de hospitalização durante todo o seguimento. A raça foi autodeclarada. O polimorfismo G894T foi analisado por reação em cadeia de polimerase e por análise do polimorfismo dos fragmentos de restrição. RESULTADOS: A frequência genotípica foi GG (40%, GT (48,3% e TT (11,7%, e a frequência alélica foi guanina (64,1% e tiamina (35,8%. Não houve diferença entre as frequências genotípica ou alélica conforme a raça autodeclarada, tampouco conforme as características basais. Não houve relação entre o genótipo ou a frequência alélica e os desfechos analisados. CONCLUSÃO: Não se observou associação do polimorfismo G894T (Glu298Asp com o prognóstico de amostra de pacientes ambulatoriais brasileiros com insuficiência cardíaca sistólica.

  3. Drugs, Herbs and Supplements: MedlinePlus

    ... https://medlineplus.gov/druginformation.html Drugs, Herbs and Supplements To use the sharing features on this page, ... included in drug packages, see DailyMed . Herbs and Supplements Browse dietary supplements and herbal remedies to learn ...

  4. Effects of supplementation with L. plantarum TN8 encapsulated in alginate-chitosan in broiler chickens.

    Trabelsi, Imen; Ktari, Naourez; Ben Slima, Sirine; Bouchaala, Kamel; Ben Salah, Riadh

    2016-08-01

    This study was undertaken to investigate the effects of supplementation of probiotic strain Lactobacillus plantarum TN8 encapsulated in sodium alginate-chitosan or a commercial blend of essential oils on total cholesterol, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL) and growth performance of broiler chickens. The results showed that the broiler chickens supplemented with encapsulated L. plantarum TN8 or essential oil has a higher growth than the control group. After 35days, the weight means were 1860 and 1880g respectively in dietary supplementation with probiotic or essential oil, while they are 1800g in the control group. The evolution of the feed consumption and feed conversion per week showed that the supplementation of encapsulated TN8 strain or essential oil in broiler chickens food has a positive influence on their appetite. Similarly, supplementation of the feed with this encapsulated strain significantly reduced the rate of cholesterol (HDL and LDL) as well as the contents of triglycerides in broiler chickens. Through our study, it appears that the use of the probiotic supplementation or essential oil to broilers were found to be better than the control group of chickens, resulting in a significant economic impact and promoting effect on health. PMID:27181580

  5. Efeitos hemodinâmicos da combinação de dexmedetomidina-fentanil versus midazolam-fentanil em crianças submetidas à cirurgia cardíaca com circulação extracorpórea Efectos hemodinámicos de la combinación de dexmedetomidina-fentanil versus midazolam-fentanil en ninõs sometidos a la cirugía cardíaca con circulación extracorpórea Hemodynamic effects of the combination of dexmedetomidine-fentanyl versus midazolam-fentanyl in children undergoing cardiac surgery with cardiopulmonary bypass

    Jyrson Guilherme Klamt

    2010-08-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Avaliar a eficácia da infusão combinada de dexmedetomidina e fentanil na resposta hemodinâmica durante cirurgia cardíaca com circulação extracorpórea (CEC em crianças. MÉTODO: Trinta e duas crianças com idade entre 1 mês e 10 anos, agendadas para cirurgia cardíaca com circulação extracorpórea, foram distribuídas de modo aleatório em dois grupos: o Grupo MDZ recebeu midazolam 0,2 mg.kg-1.h-1, enquanto o Grupo DEX recebeu dexmedetomidina 1 µg.kg-1.h-1 durante uma hora e, em seguida, o ritmo de infusão foi reduzido à metade em ambos os grupos. Ambos os grupos receberam fentanil 10 µg.kg-1, midazolam 0,2 mg.h-1 e vecurônio 0,2 mg.kg-1 para indução da anestesia. As mesmas doses de fentanil com vecurônio da indução foram infundidas durante a primeira hora após a indução e, em seguida, reduzidas à metade. As infusões foram iniciadas imediatamente após a indução e mantidas até o final da cirurgia. O isoflurano foi administrado por curto tempo para controle da resposta hiperdinâmica à incisão e esternotomia. RESULTADOS: Em ambos os grupos, a pressão arterial sistólica e a frequência cardíaca reduziram de modo significativo após uma hora de infusão anestésica, porém o aumento da pressão arterial sistólica e diastólica e da frequência cardíaca à incisão da pele foram significantemente menores no Grupo DEX. Um número significativamente menor de pacientes demandaram suplementação com isoflurano no Grupo DEX. Após a CEC, os pacientes de ambos os grupos tiveram respostas hemodinâmicas similares. CONCLUSÕES: A infusão sem bolus de dexmedetomidina parece ser um adjuvante efetivo do fentanil na promoção de sedação e controle das respostas hemodinâmicas durante cirurgia para cardiopatias congênitas em crianças.JUSTIFICATIVA Y OBJETIVOS: Evaluar la eficacia de la infusión combinada de dexmedetomidina y fentanil en la respuesta hedominámica durante la cirugía cardíaca

  6. Dietary supplements containing prohibited substances.

    van der Bijl, P; Tutelyan, V A

    2013-01-01

    Dietary supplement use among athletes to enhance performance is proliferating as more individuals strive for obtaining that chemical competitive edge. As a result the concomitant use of dietary supplements containing performance-enhancing substances of those falling in the categories outlined in the current review, can also be expected to rise. This despite ever-increasing sophisticated analytical methodology techniques being used to assay dietary supplement and urine samples in doping laboratories. The reasons for this include that a variety of these chemical entities, many of them on the prohibited drug list of the WADA, are being produced on commercial scales in factories around the world (ephedrine and pseudoephedrine, sibutramine, methylhexaneamine, prohormones, 'classic' anabolic steroids, clenbuterol, peptide hormones etc.), aggressive marketing strategies are being employed by companies and these supplements can be easily ordered via e.g. the internet. It can also be anticipated that there will be an increase in the number of supplements containing 'designer' steroids and other 'newer' molecules. Chromatographic techniques combined with mass spectrometry leading to identification of molecular fragments and productions will assist in determining these substances. To prevent accidental doping, information regarding dietary supplements must be provided to athletes, coaches and sports doctors at all levels of competition. The risks of accidental doping via dietary supplement ingestion can be minimized by using 'safe' products listed on databases, e.g. such as those available in The Netherlands and Germany. PMID:24741950

  7. Perfil de saúde de pacientes acometidos por insuficiência cardíaca Perfil de la salud de los pacientes que sufren de insuficiencia cardíaca Health profile of patients suffering from heart failure

    Guilherme Abner Sousa Almeida

    2013-06-01

    Full Text Available O estudo objetivou caracterizar os clientes com diagnóstico de Insuficiência Cardíaca (IC, segundo o modelo de Campo de Saúde, identificando fatores de risco. O estudo, com abordagem quantitativa, foi realizado por meio de entrevista com 37 pacientes com diagnóstico médico de IC; utilizou-se questionário semiestruturado baseado no modelo de "Campo de Saúde". A média de idade dos pacientes foi de 60±15 anos, com predominância do sexo feminino (59,5% e da hipertensão arterial (75,7%. O consumo de bebidas alcoólicas e o tabagismo são praticados por, respectivamente, 13,5% e 21,6% dos pacientes. Os doces e refrigerantes são consumidos diariamente por 21,6% dos pacientes. O diagnóstico de IC é desconhecido por 75,7% dos pacientes e 40,5% procuram os serviços de saúde apenas em casos de urgência. Os determinantes da saúde que compõem o Campo de Saúde indicaram um meio propício para o surgimento da IC, prejudicando a qualidade de vida da população.Estudio que objetivó describir los clientes con un diagnóstico de Insuficiencia Cardíaca (IC, de acuerdo con el modelo de Campo de Salud, identificando factores de riesgo. Este es un estudio cuantitativo, realizado a través de entrevistas con 37 pacientes con diagnóstico de IC, utilizando cuestionario semiestructurado con base en el modelo de "Campo de Salud". La edad media de los pacientes fue de 60 ± 15 años, con predominancia del sexo femenino (59,5% y mayoría con hipertensión arterial (75,7%. El consumo de bebidas alcohólicas y el tabaquismo se llevan, respectivamente, un 13,5% y 21,6% de los pacientes. Los dulces y refrescos que se consumen a diario, en un 21,6% de los pacientes. El diagnóstico de IC es desconocido (75,7% y el 40,5% de los pacientes buscan servicios de salud sólo en situaciones de emergencia. Los determinantes de la salud que componen el Campo de Salud indicaron un medio favorable para la aparición de la IC, trayendo perjuicio para la calidad de

  8. Program Calibrates Strain Gauges

    Okazaki, Gary D.

    1991-01-01

    Program dramatically reduces personnel and time requirements for acceptance tests of hardware. Data-acquisition system reads output from Wheatstone full-bridge strain-gauge circuit and calculates strain by use of shunt calibration technique. Program nearly instantaneously tabulates and plots strain data against load-cell outputs. Modified to acquire strain data for other specimens wherever full-bridge strain-gauge circuits used. Written in HP BASIC.

  9. China's Developing Dietary Supplement Industry

    Jeff Crowther

    2011-01-01

    @@ With the increasingly large size and forward momentum of China's economy, one would think there has to be a well-developed dietary supplement industry.However, although China has been posting re-cord gains to its GDP, it is far behind the U.S., E.U.and Japan in regard to a well-defined and prosperous dietary supplement industry.With that said, having an established dietary supple-ment industry is not the measure by which countries are judged in terms of economic prowess.

  10. To supplement or not to supplement: a metabolic network framework for human nutritional supplements.

    Nogiec, Christopher D; Kasif, Simon

    2013-01-01

    Flux balance analysis and constraint based modeling have been successfully used in the past to elucidate the metabolism of single cellular organisms. However, limited work has been done with multicellular organisms and even less with humans. The focus of this paper is to present a novel use of this technique by investigating human nutrition, a challenging field of study. Specifically, we present a steady state constraint based model of skeletal muscle tissue to investigate amino acid supplementation's effect on protein synthesis. We implement several in silico supplementation strategies to study whether amino acid supplementation might be beneficial for increasing muscle contractile protein synthesis. Concurrent with published data on amino acid supplementation's effect on protein synthesis in a post resistance exercise state, our results suggest that increasing bioavailability of methionine, arginine, and the branched-chain amino acids can increase the flux of contractile protein synthesis. The study also suggests that a common commercial supplement, glutamine, is not an effective supplement in the context of increasing protein synthesis and thus, muscle mass. Similar to any study in a model organism, the computational modeling of this research has some limitations. Thus, this paper introduces the prospect of using systems biology as a framework to formally investigate how supplementation and nutrition can affect human metabolism and physiology. PMID:23967053