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Sample records for abortive infection mechanism

  1. Interferon-γ promotes abortion due to Brucella infection in pregnant mice

    Suzuki Hiroshi; Furuoka Hidefumi; Watanabe Kenta; Lee Dong; Kim Suk; Watarai Masahisa

    2005-01-01

    Abstract Background The mechanisms of abortion induced by bacterial infection are largely unknown. In the present study, we investigated abortion induced by Brucella abortus, a causative agent of brucellosis and facultative intracellular pathogen, in a mouse model. Results High rates of abortion were observed for bacterial infection on day 4.5 of gestation, but not for other days. Regardless of whether fetuses were aborted or stayed alive, the transmission of bacteria into the fetus and bacte...

  2. Therapeutic abortion and Chlamydia trachomatis infection.

    Qvigstad, E; Skaug, K; Jerve, F; Vik, I S; Ulstrup, J C

    1982-01-01

    Chlamydia trachomatis was isolated from the cervix of 30 of 218 (13.8%) women admitted for legal termination of pregnancy. During the first two weeks after the abortion seven of the 30 (23.3%) patients developed pelvic inflammatory disease. Four of these had serological evidence of recent active chlamydial infection. Thus, routine examination of patients for genital chlamydial infection before termination of pregnancy is recommended.

  3. Interferon-γ promotes abortion due to Brucella infection in pregnant mice

    Suzuki Hiroshi

    2005-05-01

    Full Text Available Abstract Background The mechanisms of abortion induced by bacterial infection are largely unknown. In the present study, we investigated abortion induced by Brucella abortus, a causative agent of brucellosis and facultative intracellular pathogen, in a mouse model. Results High rates of abortion were observed for bacterial infection on day 4.5 of gestation, but not for other days. Regardless of whether fetuses were aborted or stayed alive, the transmission of bacteria into the fetus and bacterial replication in the placenta were observed. There was a higher degree of bacterial colonization in the placenta than in other organs and many bacteria were detected in trophoblast giant cells in the placenta. Intracellular growth-defective virB4 mutant and attenuated vaccine strain S19 did not induce abortion. In the case of abortion, around day 7.5 of gestation (period of placental development, transient induction of IFN-γ production was observed for infection by the wild type strain, but not by the virB4 mutant and S19. Neutralization of IFN-γ, whose production was induced by infection with B. abortus, served to prevent abortion. Conclusion These results indicate that abortion induced by B. abortus infection is a result of transient IFN-γ production during the period of placental development.

  4. Abortion

    An abortion is a procedure to end a pregnancy. It uses medicine or surgery to remove the embryo or ... personal. If you are thinking of having an abortion, most healthcare providers advise counseling.

  5. Abortion.

    1993-09-01

    Vacuum aspiration, dilatation and curettage, hysterotomy, and, in some cases, hysterectomy comprise surgical methods of abortion. Oral administration of RU-486, epostane, prostaglandins E and F2 and vaginal suppositories of prostaglandins E and F2 are medical abortion methods. The traditional or clandestine methods are usually performed by unqualified persons and pregnant women themselves. These methods tend to be inefficient and harmful. They include oral preparations of herbs and drugs (e.g., quinine and ergot), introduction of fluids (e.g., household disinfectants) into the vagina, introduction of foreign bodies (e.g., twigs, stems, hollow tubes, needles, wire) into the uterus. Hospital records, death certificates, and community-based surveys are common sources of data on abortion. Worldwide, 40-70/1000 women of childbearing age undergo an abortion. 20-33% of all pregnancies are terminated. Abortion is always legal when it is performed to save a pregnant woman's life. In most countries, it is legal to protect the woman's physical or mental health against serious danger. The risk of death from a legal abortion is rare. On the other hand, when an abortion is performed by an unqualified, unskilled abortionist and/or under unhygienic conditions (all of which are common in countries who have a law against abortion) the risk of death is much higher. In fact, abortion is one of the leading causes of maternal death in many countries (25% and 86% of maternal deaths in Bangladesh and Romania, respectively). Common complications of abortion are incomplete abortion, trauma to pelvic organs (e.g., uterine perforation), tetanus, and infertility. In some developing countries, the cost of treating abortion complications account for up to 50% of maternity hospital budgets. Ways to reduce mortality from unsafe abortion include promoting contraceptive use, legalizing abortion, allowing trained practitioners to perform abortions for health reasons, and improving clinical management

  6. Abortions in sheep associated with Arcobacter skirrowii infection.

    Bath, Gareth F; Leask, Rhoda; Pettey, Kenneth P; Coetzee, Debra J

    2013-01-01

    The history, circumstances, clinical signs, post mortem lesions, morbidity, mortality and laboratory findings are described in an abortion storm in sheep that occurred in Mpumalanga, South Africa, associated with infection with Arcobacter skirrowii. Altogether, about 200 Suffolk Down ewes lost 60 lambs in late pregnancy or at term. Although only three foetuses were submitted for investigation, two had signs consistent with a diagnosis of A. skirrowii infection and the organism was isolated from the placentas of both specimens. No abortions had occurred in previous years, or have subsequently. There were no animal introductions prior to the outbreak that could have indicated a source of infection. One stillborn lamb submitted subsequently had lesions consistent with dystocia, and the history and circumstantial evidence indicated that dystocia had been a factor in several more losses. No ewes or rams had shown signs of diarrhoea or other diseases associated with A. skirrowii infection. Twenty-two faecal, preputial and vaginal swab specimens taken from six rams and 13 ewes after the abortion event were all negative for A. skirrowii. This is the first report of abortions in sheep associated with A. skirrowiiin South Africa. Because the genus Arcobacter is similar to Campylobacter, it is possible that infection has gone unrecognised in the past. Veterinarians and laboratories should take note and include this genus in the list of potential abortifacient organisms. The possible role of Arcobacter species in other diseases like enteritis and mastitis, as well as the potential role as a zoonosis, must be borne in mind. PMID:27476399

  7. Abortions in sheep associated with Arcobacter skirrowii infection

    Gareth F. Bath

    2013-02-01

    Full Text Available The history, circumstances, clinical signs, post mortem lesions, morbidity, mortality and laboratory findings are described in an abortion storm in sheep that occurred in Mpumalanga, South Africa, associated with infection with Arcobacter skirrowii. Altogether, about 200 Suffolk Down ewes lost 60 lambs in late pregnancy or at term. Although only three foetuses were submitted for investigation, two had signs consistent with a diagnosis of A. skirrowii infection and the organism was isolated from the placentas of both specimens. No abortions had occurred in previous years, or have subsequently. There were no animal introductions prior to the outbreak that could have indicated a source of infection. One stillborn lamb submitted subsequently had lesions consistent with dystocia, and the history and circumstantial evidence indicated that dystocia had been a factor in several more losses. No ewes or rams had shown signs of diarrhoea or other diseases associated with A. skirrowii infection. Twenty-two faecal, preputial and vaginal swab specimens taken from six rams and 13 ewes after the abortion event were all negative for A. skirrowii. This is the first report of abortions in sheep associated with A. skirrowiiin South Africa. Because the genus Arcobacter is similar to Campylobacter, it is possible that infection has gone unrecognised in the past. Veterinarians and laboratories should take note and include this genus in the list of potential abortifacient organisms. The possible role of Arcobacter species in other diseases like enteritis and mastitis, as well as the potential role as a zoonosis, must be borne in mind.

  8. Abortion

    1985-01-01

    The Canadian Medical Association (CMA) recognizes that there is justification for abortion on medical and nonmedical socioeconomic grounds and that such an elective surgical procedure should be decided upon by the patient and the physician(s) concerned. Ideally, the service should be available to all women on an equitable basis across Canada. CMA has recommended the removal of all references to hospital therapeutic abortion committees as outlined in the Criminal Code of Canada. The Criminal C...

  9. Reproductive tract infections in women seeking abortion in Vietnam

    Thủy Đỗ

    2009-01-01

    Full Text Available Abstract Background Women requesting abortion are at increased risk of developing RTI complications. However, RTI control in many resource-poor countries including Vietnam have been faced with logistical and methodological problems due to lack of standardized definitions of RTIs, lack of well-validated diagnostic criteria, lack of accurate laboratory tests, and lack of diagnostic equipment and skills. This article investigates the prevalence of RTIs among Vietnamese abortion-seeking women, to evaluate the available diagnostic techniques, and to assess antibiotic resistance among aetiological agents of RTI. Method The study was conducted in Phu-San hospital (PSH from December 2003 through April 2004 among 748 abortion clients. A structured questionnaire was used to collect data on socio-economic and reproductive characteristics. Specimens were collected for laboratory analyses of chlamydia, gonorrhoea, trichomoniasis, vaginal candidiasis (VC, bacterial vaginosis (BV and syphilis. To assess the validity of the obtained results, the study was repeated among 100 women and the duplicate samples were analysed at PSH and Copenhagen University Hospital (CUH. Results In all 54% of the women were diagnosed as having an RTI, including 3.3% with sexually transmitted infections. Endogenous infections were most prevalent (VC 34% and BV 12% followed by chlamydia (1.3% and trichomoniasis (0.7%. The sensitivity of culture for VC and BV was 30% and 88%, respectively, when tests in PSH were measured against tests in CUH. Antibiotic resistance was common among bacterial isolates. Conclusion RTIs are common among women seeking abortion. The presence of RTIs is associated with an increased risk of developing iatrogenic infections, routine administration of prophylactic antibiotic to all women undergoing abortion should be considered. However, the choice of routine prophylactic antibiotics should be based on relevant surveillance data of antibiotic resistance

  10. Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep.

    David Longbottom

    Full Text Available BACKGROUND: Latency is a key feature of the animal pathogen Chlamydia abortus, where infection remains inapparent in the non-pregnant animal and only becomes evident during a subsequent pregnancy. Often the first sign that an animal is infected is abortion occurring late in gestation. Despite this, little is understood of the underlying mechanisms that control latency or the recrudescence of infection that occurs during subsequent pregnancy. The aim of this study was to develop an experimental model of latency by mimicking the natural route of infection through the intranasal inoculation of non-pregnant sheep with C. abortus. METHODOLOGY/PRINCIPAL FINDINGS: Three groups of sheep (groups 1, 2 and 3 were experimentally infected with different doses of C. abortus (5×10(3, 5×10(5 and 5×10(7 inclusion forming units (IFU, respectively prior to mating and monitored over 2 breeding cycles for clinical, microbiological, pathological, immunological and serological outcomes. Two further groups received either negative control inoculum (group 4a,b or were inoculated subcutaneously on day 70 of gestation with 2×10(6 IFU C. abortus (group 5. Animals in groups 1, 2 and 5 experienced an abortion rate of 50-67%, while only one animal aborted in group 3 and none in group 4a,b. Pathological, microbiological, immunological and serological analyses support the view that the maternal protective immune response is influenced by initial exposure to the bacterium. CONCLUSIONS/SIGNIFICANCE: The results show that intranasal administration of non-pregnant sheep with a low/medium dose of C. abortus results in a latent infection that leads in a subsequent pregnancy to infection of the placenta and abortion. In contrast a high dose stimulates protective immunity, resulting in a much lower abortion rate. This model will be useful in understanding the mechanisms of infection underlying latency and onset of disease, as well as in the development of novel therapeutics and

  11. Abortion.

    Savage, A

    1979-09-15

    I refer for termination anyone who requests it for--pace Mr V Tunkel, (28 July, p 253)--the law is generally regarded as being one of "abortion on demand." I have some misgivings as I do not believe that women in early pregnancy are always in a fit state to make a considered decision, and they cannot in the nature of things be given time. I have, however, become increasingly worried about the morbidity arising from the procedure, and it is interesting that letters on the subject (25 August, pp 495 and 496) should be followed by one reporting rupture of the uterus during prostaglandin-induced abortion--yet another complication to add to those of cervical incompetence, pelvic sepsis, and permanent neurological damage. In so far as these tragedies usually follow late terminations Mr John Corrie's Bill is to be welcomed. A few further points. I am not so cynical as to think that every impregnation is the result of a thoughtless act of male lust. Unlike Professor Peter Huntingford (25 August, p 496), I listen to men as well as women, and many of them are deeply involved emotionally in the pregnancy they have helped to produce. Certainly I think a man should have the right to be consulted if his wife is to undergo a procedure that might damage her health. It is unfair contemptuously to dismiss as "whims" opinions that differ from ones own. These may result from genuine conscientious doubts or inability to cope from overwork and understaffing. Abortion is quite the most expensive form of contraception, and perhaps in these days of financial stringency this should be taken into account. "Bigotry" is defined in my dictionary as "blind zeal." This could be said of those who enthusiastically promote a course of action without regard to circumstances, safety, or cost. PMID:497770

  12. Histopathological and molecular study of Neospora caninum infection in bovine aborted fetuses

    Amir Kamali; HesamAdin Seifi; Ahmad Reza Movassaghi; Gholam Reza Razmi; Zahra Naseri

    2014-01-01

    To estimate the extent to which abortion in dairy cows was associated with of Neospora caninum (N. caninum) and to determine the risk factors of neosporosis in dairy farms from 9 provinces in Iran. Methods: Polymerase chain reaction (PCR) test was used to detect Neospora infection in the brain of 395 bovine aborted fetuses from 9 provinces of Iran. In addition, the brains of aborted fetuses were taken for histopathological examination. To identify the risk factors associated with neosporosis, data analysis was performed by SAS. Results: N. caninum was detected in 179 (45%) out of 395 fetal brain samples of bovine aborted fetuses using PCR. Among the PCR-positive brain samples, only 56 samples were suited for histopathological examination. The characteristic lesions of Neospora infection including non-suppurative encephalitis were found in 16 (28%) of PCR-positive samples. The risk factors including season, parity of dam, history of bovine virus diarrhea and infectious bovine rhinotracheitis infection in herd, cow’s milk production, herd size and fetal appearance did not show association with the infection. This study showed that Neospora caused abortion was significantly more in the second trimester of pregnancy than other periods. In addition, a significant association was observed between Neospora infection and stillbirth. Conclusions: The results showed N. caninum infection was detected in high percentage of aborted fetuses. In addition, at least one fourth of abortions caused by Neospora infection. These results indicate increasing number of abortions associated with the protozoa more than reported before in Iran.

  13. Histopathological and molecular study of Neospora caninum infection in bovine aborted fetuses

    Amir; Kamali; Hesam; Adin; Seifi; Ahmad; Reza; Movassaghi; Gholam; Reza; Razmi; Zahra; Naseri

    2014-01-01

    Objective:To estimate the extent to which abortion in dairy cows was associated with of Neospom caninum(N.caninum) and to determine the risk factors of neosporosis in dairy farms from 9 provinces in Iran.Methods:Polymerase chain reaction(PCR) test was used to detect Neospora infection in the brain of 395 bovine aborted fetuses from 9 provinces of Iran.In addition,the brains of aborted fetuses were taken for histopathological examination.To identify the risk factors associated with neosporosis,data analysis was performed by SAS.Results:N.caninum was detected in 179(45%) out of 395 fetal brain samples of bovine aborted fetuses using PCR.Among the PCR-positive brain samples,only 56 samples were suited for histopathological examination.The characteristic lesions of Neospora infection including non-suppurative encephalitis were found in 16(28%) of PCR-positive samples.The risk factors including season,parity of dam,history of bovine virus diarrhea and infectious bovine rhinotracheitis infection in herd,cow’s milk production,herd size and fetal appearance did not show association with the infection.This study showed that Neospora caused abortion was significantly more in the second trimester of pregnancy than other periods.In addition,a significant association was observed between Neospora infection and stillbirth.Conclusions:The results showed N.caninum infection was detected in high percentage of aborted fetuses.In addition,at least one fourth of abortions caused by Neospora infection.These results indicate increasing number of abortions associated with the protozoa more than reported before in Iran.

  14. Toxoplasma gondii abortion storm in sheep on a Texas farm and isolation of mouse virulent atypical genotype T. gondii from an aborted lamb from a chronically infected ewe

    Sheep are commonly infected with the protozoan parasite, Toxoplasma gondii. Infection may cause early embryonic death and resorption, fetal death and mummification, abortion, stillbirth, and neonatal death. Most sheep acquire T. gondii infection after birth. Recent studies reported that repeat ovine...

  15. Cytokine gene expression in aborting and non-aborting dams and in their foetuses after experimental infection with Neospora caninum at 110 days of gestation.

    Almeria, S; Serrano-Pérez, B; Darwich, L; Mur-Novales, R; Garcia-Ispierto, I; Cabezón, O; López-Gatius, F

    2016-08-30

    Neospora caninum is a major cause of abortion in cattle. However, it is not known why not all infected animals abort. In this study, Th1 (IFN-γ), Th2 (IL4) and T reg (IL-10) cytokine gene expression was examined by real time PCR using the TaqMan approach in all of these dams and their foetuses after experimental infection with the isolate Nc-Spain7 at 110 days of pregnancy and euthanasia 6 weeks after infection. In prior published work, foetal death was observed in three of six infected dams and transplacental infection in all the 6 infected foetuses. In the spleen of the dams, IL-4 expression was down-regulated in dams with aborted/non viable foetuses compared to both uninfected dams (controls, n=3) and infected dams with live fetuses at euthanasia. In the lymph nodes draining the placenta, up-regulated expression of IL-4 was observed in infected dams with live foetuses compared to control dams. In the placenta, infected dams with live foetuses had significantly up-regulated IFN-γ in both caruncle and cotyledon and up-regulated IL-10 in cotyledon compared to control dams. Infected live foetuses showed up-regulated expression of IFN-γ and IL-10 in foetal spleen, and showed downregulated expression of IL-4 in the thymus compared to control uninfected foetuses. Expression of any cytokine in the thymus was significantly lower compared to the levels observed in foetal spleen. The results indicate an up-regulated expression of Th1, Th2 and Treg in infected dams with live foetuses and in their foetuses. On the other hand, down-regulation of Th2 immune responses and Treg cytokines were observed in infected dams which had aborted or had non-viable foetuses at euthanasia, suggesting an immunological recovery of cytokine gene expression levels in dams a few weeks after an abortion occurred. PMID:27523950

  16. A randomised controlled trial of prophylaxis of post-abortal infection: ceftriaxone versus placebo

    Henriques, C U; Wilken-Jensen, C; Thorsen, P;

    1994-01-01

    OBJECTIVE: To investigate the incidence of post-operative infection after first trimester abortion in women treated with a long-acting cephalosporin (ceftriaxone) compared with low risk patients receiving no treatment and with high risk patients receiving our standard treatment of ampicillin/piva...

  17. Pelvic inflammatory disease associated with Chlamydia trachomatis infection after therapeutic abortion. A prospective study.

    Qvigstad, E; Skaug, K; Jerve, F; Fylling, P; Ulstrup, J C

    1983-01-01

    Chlamydia trachomatis was cultured from the cervix of 70 of 557 (12.6%) patients admitted for therapeutic abortion. Postoperatively, 22 (3.9%) developed acute pelvic inflammatory disease (PID); of these women, 14 (63.6%) had harboured C trachomatis in the cervix before the abortion. Thus of 70 patients with chlamydial infection, 14 (20%) developed PID postoperatively. Of the chlamydia-positive patients, six of the 15 (40%) aged less than 20 years and eight of the 53 (15%) patients aged 20-30 ...

  18. Concomitant infection of Neospora caninum and Bovine Herpesvirus type 5 in spontaneous bovine abortions

    Maia S. Marin

    2013-11-01

    Full Text Available Bovine Herpesvirus type 5 (BoHV-5 has not been conclusively demonstrated to cause bovine abortion. Brain lesions produced by Neospora caninum and Bovine Herpesvirus type 1 (BoHV-1 exhibit common features. Therefore, careful microscopic evaluation and additional diagnostic procedures are required to achieve an accurate final etiological diagnosis. The aim of the present work was to investigate the occurrence of infections due to BoHV-1, BoHV-5 and N. caninum in 68 cases of spontaneous bovine abortions which showed microscopic lesions in the fetal central nervous system. This study allowed the identification of 4 (5.9% fetuses with dual infection by BoHV-5 and N. caninum and 33 (48.5% cases in which N. caninum was the sole pathogen identified. All cases were negative to BoHV-1. The results of this study provide evidence that dual infection by BoHV-5 and N. caninum occur during pregnancy in cattle; however, the role of BoHV-5 as a primary cause of bovine abortion needs further research. Molecular diagnosis of BoHV-5 and N. caninum confirmed the importance of applying complementary assays to improve the sensitivity of diagnosing bovine abortion.

  19. Molecular and Pathological Study of Bovine Aborted Fetuses and Placenta from Neospora caninum Infected Dairy Cattle

    P Shayan

    2009-07-01

    Full Text Available "nBackground: The objective of the study was to evaluate the presence of Neospora caninum organisms in the brain of aborted fetuses and placentas of full-term calves born of seropositive cows. "nMethods: During 2006-2007, 12 brains of aborted calves from Neospora seropositive cattle and 7 pla­centas from seropositive dams giving birth to full-term calves, from four dairy cattle farms located around Tehran province, Iran were examined by Nested-PCR and histopathology techniques. "nResult: The Nested-PCR demonstrated that all of 12 aborted fetal brain samples and 5 of 7 placentas were infected by N. caninum. Mild to severe placentitis was observed in 5 placentas. Severe hyperemia and pe­rivascular and perineuronal edema revealed in all fetal brain. In 3 out of 12 brains, scattered foci of he­morrhages, neuropilar necrosis and gliosis were present. In addition, nonpurulent encephalitis with severe lymphohistiocytic perivascular cuffing in one case and a small tissue cyst like Neospora caninum cyst in other calf were observed. "n Conclusion: Our results confirmed the molecular and histopathologic findings of other studies about Neos­pora caninum infection and it seems to support the hypothesis that Neospora infection is associated with bovine abortion in Iran.

  20. Abortion - medical

    ... womb (uterus). There are different types of medical abortions: Therapeutic medical abortion is done because the woman has ... Therapeutic medical abortion; Elective medical abortion; Induced abortion; Nonsurgical abortion

  1. Reproductive tract infections in women seeking abortion in Vietnam

    Nguyen, My Huong; Kurtzhals, Jørgen; Do, Thi Thu Thuy;

    2009-01-01

    as having an RTI, including 3.3% with sexually transmitted infections. Endogenous infections were most prevalent (VC 34% and BV 12%) followed by chlamydia (1.3%) and trichomoniasis (0.7%). The sensitivity of culture for VC and BV was 30% and 88%, respectively, when tests in PSH were measured against tests...

  2. Kinetics of Infection and Effects on Placental Cell Populations in a Murine Model of Chlamydia psittaci-Induced Abortion

    Buendía, Antonio J.; Sánchez, Joaquín; Martínez, María C.; Cámara, Paulina; Navarro, Jose A.; Rodolakis, Annie; Salinas, Jesus

    1998-01-01

    The anatomical progression of chlamydial infection was studied in different areas of the placenta, using a mouse model and two inoculation times: early pregnancy (day 7, group A) and midpregnancy (day 11, group B). The first population cells affected were decidual cells and neutrophils located just at the limits of the maternal and fetal placenta. The following invaded area was the layer of giant cells. Complete colonization of the maternal placenta occurred after day 15 of pregnancy independently of the inoculation time, the metrial gland being the last area to be invaded; numerous granulated metrial gland (GMG) cells were infected. Finally, chlamydial inclusions were observed in labyrinthine trophoblastic cells from day 18 of pregnancy onward. Since no fetal damage was observed, it seems that an indirect mechanism involving the lysis of GMG cells and neutrophil infiltration of the decidua and metrial gland may be the pathogenic mechanism that leads to abortion. PMID:9573099

  3. Laws Requiring Parental Involvement to Obtain Abortion and Prevalence of Sexually Transmitted Infections Among Minors.

    Silvie Colman; Ted Joyce; Thomas S. Dee

    2011-01-01

    Report evaluates whether policies requiring parental involvement in minors' decision to obtain an abortion can alter their sexual behavior and help reduce the rates of sexually transmitted infections (STIs) among teens. Using data from the STI surveillance system of the Centers for Disease Control and Prevention on cases of gonorrhea and chlamydia, the findings offer little evidence of a link between parental involvement laws and teen STI rates.

  4. Detection and Identification of Toxoplasma gondii Type One Infection in Sheep Aborted Fetuses in Qazvin Province of Iran

    M Kamalzade

    2012-09-01

    Full Text Available Background: The aim of this study was to apply the nested-PCR and bioassay methods in detection and genotyping of Toxoplasma gondii infection in provided sheep aborted fetus samples from Qazvin Province of Iran. Methods: Eighteen sheep aborted fetal samples were studied by nested-PCR-RFLP, histopathologi­cal observation and microbiological assay. Bioassay in mice was carried out by inoculating the brain samples intraperitoneally. Results: The results demonstrated the frequency of 66% infected sheep aborted fetal samples with T. gondii type one. Although we could not isolate any parasite from inoculated mice even after three pas­sages, but it was confirmed histopathologically formation of cyst like bodies in prepared mice brain sections. Conclusion: The results of the performed nested-PCR and formation of brain cyst in inoculated mice exhibited that T. gondii type one infection might be considered as one of the major causative agents for abortion in ewes.

  5. Cerebral Candidal Abscess and Bovine Viral Diarrhoea Virus Infection in an Aborted Bovine Fetus.

    Vilander, A C; Niles, G A; Frank, C B

    2016-01-01

    Candida species are opportunistic fungi associated with immunosuppression and are the most commonly isolated fungal pathogens from the human central nervous system. Invasive candidiasis is reported uncommonly in animals and there have only been two reports of candidal infection of the brain. This report presents a case of a cerebral candidal abscess in an aborted late-term calf co-infected with bovine viral diarrhoea virus. Candida etchellsii, a species not previously identified as pathogenic, was identified as the causative agent by polymerase chain reaction. PMID:26895887

  6. Comparison of abortion and infection after experimental challenge of pregnant bison and cattle with Brucella abortus strain 2308

    A comparative study was conducted using data from naive bison (n=45) and cattle (n=46) from 8 and 6 studies, respectively, in which a standardized Brucella abortus strain 2308 experimental challenge was administered. The incidence of abortion, fetal infection, uterine or mammary infection, or infec...

  7. De novo transcriptome sequencing and gene expression analysis reveal potential mechanisms of seed abortion in dove tree (Davidia involucrata Baill.)

    Li, Meng; Dong, Xujie; Peng, Jiqing; Xu, Wen; Ren, Rui; Liu, Jane; Cao, Fuxiang; Liu, Zhiming

    2016-01-01

    Background Dove tree (Davidia involucrata Baill.) is a rare and endangered species. Natural reproduction of dove tree is extremely difficult due to its low fecundity. Serious seed abortion is one of the key factors restraining its sexual reproduction. Understanding the inducements of seed abortion is critical for addressing the issue of offspring production and the survivability of such an endangered species. However, studies on the molecular mechanism of seed abortion in woody plants are lac...

  8. Abortion - surgical

    Suction curettage; Surgical abortion; Elective abortion - surgical; Therapeutic abortion - surgical ... problem. Your pregnancy is harmful to your health (therapeutic abortion). The pregnancy resulted after a traumatic event such ...

  9. [Herpetic infection of spermatozoa in failure of reproductive technologies and spontaneous abortion].

    Bocharova, E N; Bragina, E E; Gusak, Iu K; Zotov, V V; Tereshchenko, A B; Shileĭko, L V; Kurilo, L F; Klimova, R R; Kushch, A A

    2007-01-01

    Herpes simplex virus (HSV) was studied in ejaculate of 36 men whose wives had the history of spontaneous abortions, or failure of artificial insemination (AI), or extracorporeal fertilization (ECF). The control group consisted of 222 patients examined prophylactically after urogenital inflammation or for primary infertility. HSV was detected with immunofluorescence (IF) reaction with monoclonal antibodies to HSV antigens, rapid culture method (RCM) and transmission electronic microscopy. HSV antigens were detected in fraction of mobile spermatozoa in 13 (65%) of 20 samples from patients of the study group. HSV detectability in the study group was significantly higher than in the controls (p = 0.003). Intragametic capsides of HSV were detected at ultrastructural investigation in 13 of 19 (68%) ejaculate samples from patients of the study group in whom IF and/ or RCM results were positive. The study of 6 ejaculate samples of this group in which HSV was not detected by IF or RCM and 24 control samples HSV capsides were not detected. The following conclusions can be made: mobile spermatozoa of normal morphology can be infected with HSV; as shown morphologically, samples of ejaculate from men whose wives had spontaneous abortions contained intragametic HSV capsides; intragametic HSV infection of spermatozoa had a negative effect on the course of pregnancy and/or embryon vitality. PMID:17722621

  10. Activation of mRNA translation by phage protein and low temperature: the case of Lactococcus lactis abortive infection system AbiD1

    Ehrlich S Dusko

    2009-01-01

    Full Text Available Abstract Background Abortive infection (Abi mechanisms comprise numerous strategies developed by bacteria to avoid being killed by bacteriophage (phage. Escherichia coli Abis are considered as mediators of programmed cell death, which is induced by infecting phage. Abis were also proposed to be stress response elements, but no environmental activation signals have yet been identified. Abis are widespread in Lactococcus lactis, but regulation of their expression remains an open question. We previously showed that development of AbiD1 abortive infection against phage bIL66 depends on orf1, which is expressed in mid-infection. However, molecular basis for this activation remains unclear. Results In non-infected AbiD1+ cells, specific abiD1 mRNA is unstable and present in low amounts. It does not increase during abortive infection of sensitive phage. Protein synthesis directed by the abiD1 translation initiation region is also inefficient. The presence of the phage orf1 gene, but not its mutant AbiD1R allele, strongly increases abiD1 translation efficiency. Interestingly, cell growth at low temperature also activates translation of abiD1 mRNA and consequently the AbiD1 phenotype, and occurs independently of phage infection. There is no synergism between the two abiD1 inducers. Purified Orf1 protein binds mRNAs containing a secondary structure motif, identified within the translation initiation regions of abiD1, the mid-infection phage bIL66 M-operon, and the L. lactis osmC gene. Conclusion Expression of the abiD1 gene and consequently AbiD1 phenotype is specifically translationally activated by the phage Orf1 protein. The loss of ability to activate translation of abiD1 mRNA determines the molecular basis for phage resistance to AbiD1. We show for the first time that temperature downshift also activates abortive infection by activation of abiD1 mRNA translation.

  11. Induced Abortion

    ... Education & Events Advocacy For Patients About ACOG Induced Abortion Home For Patients Search FAQs Induced Abortion Page ... Induced Abortion FAQ043, May 2015 PDF Format Induced Abortion Special Procedures What is an induced abortion? What ...

  12. Abortion - medical

    Therapeutic medical abortion; Elective medical abortion; Induced abortion; Nonsurgical abortion ... A medical, or nonsurgical, abortion can be done within 7 weeks from the first day of the woman's last ...

  13. Expression of prostaglandin receptors in Chlamydia trachomatis-infected recurrent spontaneous aborters.

    Singh, Namita; Prasad, Priya; Singh, Laishram Chandreshwar; Das, Banashree; Rastogi, Sangita

    2016-06-01

    A study was undertaken to quantify the expression of prostaglandin (PG) receptors and find the effect of gestational age on expression of PG receptor genes in Chlamydia trachomatis-infected recurrent spontaneous aborters (RSA). Endometrial curettage tissue (ECT) was collected from 130 RSA (Group I) and 100 age-matched controls (Group II) at the Department of Obstetrics and Gynecology, Safdarjung Hospital, New Delhi (India). PCR was performed for diagnosis of C. trachomatis cryptic plasmid; mRNA expression of PG receptor genes was assessed by real-time PCR (q-PCR), while serum progesterone/estrogen levels were determined by respective commercial kits. Data were evaluated statistically. A total of 15.4 % RSA (GroupI) were diagnosed as C. trachomatis-positive (200 bp), whereas controls were uninfected. q-PCR showed significant upregulation (PRSA, mean serum progesterone level was significantly low (PRSA. PMID:27028620

  14. Markers related to the diagnosis and to the risk of abortion in bovine neosporosis.

    Almería, Sonia; López-Gatius, Fernando

    2015-06-01

    Bovine neosporosis has emerged as a main cause of abortion in cattle worldwide. An important question to understand the disease is why not all infected cows abort. In the present review we summarize the knowledge on markers related to the diagnosis and more importantly to the risk of abortion in the infected cow. Markers considered herein include those based on specific antibodies, antibody titers and antibody subtypes, cellular immunological markers, hormones and other proteins related to gestation. The identification of parasite molecules that are specifically identified in the aborting cows might help to understand the mechanism of parasite-associated abortion and control the disease. PMID:25841793

  15. Abortion - surgical

    Suction curettage; Surgical abortion; Elective abortion - surgical; Therapeutic abortion - surgical ... Surgical abortion involves dilating the opening to the uterus (cervix) and placing a small suction tube into the uterus. ...

  16. GENETIC POLYMORPHISM OF TOXOPLASMA GONDII FROM RECENTLY INFECTED ABORTED EGYPTIAN WOMEN.

    Badr, Mohamed S; Attia, Samar S; El-Sherbiny, Walid S; Abd-Allah M A, El Ebidi; Hefny, Hesham M; Salem, Ahmed N M

    2016-04-01

    Toxoplasmosis caused by Toxoplasma gondii is one of the most prevalent parasitic diseases in human beings. Human toxoplasmosis can be associated with serious clinical manifestations, particularly in developing fetus. The aim of the current study was to identify the possible lineage type of Toxoplasma gondii, molecularly detected in placental samples of women whose pregnancies were spontaneously terminated in the first trimester. Preliminary detection of Toxoplasma genomic materials was done by a SYBR green qPCR technology. Subsequent identification of Toxoplasma strain was done for the positive samples using PCR-restriction fragment length polymorphism (RFLP) at the SAG2 loci of T. gondii using restriction enzymes HhaI and Sau3AI. Out of 72 tested samples, Toxoplasma B1 gene was detected in 9 cases. Toxoplasma genotypes I and II in addition to unknown type were identified in 4, 3 and 2 cases respectively, while type III was not detected in our samples, hence excluded as a leading cause of abortion in humans in our preliminary study. Nevertheless, it remains uncertain to what extent the genotype of the parasite directly contributes to the clinical severity of human toxoplasmosis. Certainly, advanced molecular techniques targeting different Toxoplasma strains are crucial for better understanding of human toxoplasmosis. For more elucidation, additional studies are recommended intended for genetic characterization of such serious parasitic infection using larger number of samples. PMID:27363040

  17. Isolation of viable Toxoplasma gondii from naturally infected aborted bovine fetuses.

    Canada, Nuno; Meireles, Carla S; Rocha, A; da Costa, J M Correia; Erickson, M W; Dubey, J P

    2002-12-01

    Neospora caninum and Toxoplasma gondii are related parasites. The former is a common cause of abortion in dairy cattle. The latter has not been conclusively demonstrated in bovine fetuses. During the course of attempts to isolate N. caninum from aborted fetuses, T. gondii was isolated from 2 aborted fetuses, 1 from Portugal and 1 from the United States. Both isolates were made by bioassay of fetal brains in mice. The fetus from Portugal was about 5 mo in gestational age, and the fetus from the United States was a full-term stillborn. PMID:12537120

  18. High prevalence of unwanted pregnancies and induced abortions among HIV-infected women from Western India : need to emphasize dual method use?

    Darak, Shrinivas; Hutter, Inge; Kulkarni, Vinay; Kulkarni, Sanjeevani; Janssen, Fanny

    2016-01-01

    This study examines the prevalence, reasons, and predictors of unwanted pregnancies and induced abortions among ever married HIV-infected women attending a care facility in Maharashtra, Western India, and discusses its programmatic and policy implications. Retrospectively collected data of pregnanci

  19. Investigation of Bovine Viral Diarrheae Virus, Bovine Herpesvirus 1, and Bovine Leukosis Virus infections in a dairy cattle herd with abortion problem

    Avcı, Oğuzhan; Yavru, Sibel; Kale, Mehmet

    2014-01-01

    A survey was conducted to determine of Bovine Viral Diarrhea Virus, Bovine Herpesvirus 1 and Bovine Leukosis Virus infections in a dairy cattle herd with abortion problem in Çankırı. A total of 172 serum and 172 leukocytes samples were collected from unvaccinated Holstein cows for mentioned infections in 2010. All sampled animals were over 3 years. While the serum samples were analysed by commercially available indirect enzyme linked immunosorbent assays (ELISA), leukocyte samples...

  20. Group A Streptococcus Endometritis following Medical Abortion

    Gendron, Nicolas; Joubrel, Caroline; Nedellec, Sophie; Campagna, Jennifer; Agostini, Aubert; Doucet-Populaire, Florence; Casetta, Anne; Raymond, Josette; Poyart, Claire; Kernéis, Solen

    2014-01-01

    Medical abortion is not recognized as a high-risk factor for invasive pelvic infection. Here, we report two cases of group A Streptococcus (GAS; Streptococcus pyogenes) endometritis following medical abortions with a protocol of oral mifepristone and misoprostol.

  1. Prematurity and Abortion

    Francisco Jover-Díaz

    2001-01-01

    Full Text Available Background: Although the pathogenic role of Coxiella burnetii infection during pregnancy is controversial, some cases of stillbirth and abortion occurring after an acute or chronic infection have been mentioned in the literature. Recently, Q fever has been advocated as a significant cause of morbidity and mortality in pregnancy

  2. Mouse model for abortive rabies infection of the central nervous system.

    Smith, J S

    1981-01-01

    When adult mice were injected by the footpad route with the attenuated rabies virus ERA/BHK, serum- and brain-associated antibody and interferon were produced, nonspecific cytotoxic cells and virus-specific cytolytic T cells in the spleen were activated, and a nonlethal infection of the central nervous system occurred. Cyclophosphamide treatment of these animals 1 day after virus infection suppressed antibody formation and induction of cytolytic T cells and resulted in a lethal infection. Vir...

  3. Quantitative detection of Neospora caninum in bovine aborted fetuses and experimentally infected mice by real-time PCR.

    Collantes-Fernández, Esther; Zaballos, Angel; Alvarez-García, Gema; Ortega-Mora, Luis M

    2002-04-01

    We report the development of a real-time PCR assay for the quantitative detection of Neospora caninum in infected host tissues. The assay uses the double-stranded DNA-binding dye SYBR Green I to continuously monitor product formation. Oligonucleotide primers were designed to amplify a 76-bp DNA fragment corresponding to the Nc5 sequence of N. caninum. A similar method was developed to quantify the 28S rRNA host gene in order to compare the parasite load of different samples and to correct for the presence of potential PCR-inhibiting compounds in the DNA samples. A linear quantitative detection range of 6 logs with a calculated detection limit of 10(-1) tachyzoite per assay was observed with excellent linearity (R(2) = 0.998). Assay specificity was confirmed by using DNA from the closely related parasite Toxoplasma gondii. The applicability of the technique was successfully tested in a variety of host brain tissues: (i) aborted bovine fetuses classified into negative or positive Neospora-infected animals according to the observation of compatible lesions by histopathological study and (ii) experimentally infected BALB/c mice, divided into three groups, inoculated animals with or without compatible lesions and negative controls. All samples were also tested by ITS1 Neospora nested PCR and a high degree of agreement was shown between both PCR techniques (kappa = 0.86). This technique represents a useful quantitative diagnostic tool to be used in the study of the pathogenicity, immunoprophylaxis, and treatment of Neospora infection. PMID:11923330

  4. Detection of porcine circovirus genotypes 2a and 2b in aborted foetuses from infected swine herds in the State of São Paulo, Brazil

    de Castro Alessandra MMG

    2012-05-01

    Full Text Available Abstract Background Porcine circovirus type 2 (PCV2 has been associated with several disease complexes, including reproductive failure. The aim of this study was to identify the subtypes of PCV2 that are associated with reproductive failure in pigs from the State of São Paulo, Brazil and to investigate co-infections with other infectious organisms. Findings Samples of 168 aborted foetuses or mummified foetuses from five farrow-to-finish swine farms known to be infected with PCV2 and located in the State of São Paulo were tested for PCV2 by polymerase chain reaction (PCR. Positive samples were additionally tested for porcine parvovirus (PPV, Leptospira spp. and Brucella spp. by PCR. PCV2 was detected in 18 of the samples (10.7%. PPV, Brucella spp. and Leptospira spp were found in 2, 10 and 0 cases, respectively. Eleven PCV2 strains were sequenced and determined to be either genotype 2a (n = 1 or 2b (n = 10. Conclusions The findings indicate that the frequency of PCV2 infections in aborted porcine foetuses from the State of São Paulo is rather low (10.7% and that co-infection with other pathogens is common and may be involved in PCV2 associated reproductive failure. No repeatable, characteristic amino acid motifs for regions of the PCV2 capsid protein seemed to be associated with abortion in sows.

  5. Ovine Enzootic Abortion (OEA): a comparison of antibody responses in vaccinated and naturally-infected swiss sheep over a two year period

    Gerber, Andrea; Thoma, Ruedi; Vretou, Evangelia; Psarrou, Evgenia; Kaiser, Carmen; Doherr, Marcus G.; Zimmermann, Dieter R; Polkinghorne, Adam; Pospischil, Andreas; Borel, Nicole

    2007-01-01

    BACKGROUND: Prevention and control of ovine enzootic abortion (OEA) can be achieved by application of a live vaccine. In this study, five sheep flocks with different vaccination and infection status were serologically tested using a competitive enzyme-linked immunosorbent assay (cELISA) specific for Chlamydophila (Cp.) abortus over a two-year time period. RESULTS: Sheep in Flock A with recent OEA history had high antibody values after vaccination similar to Flock C with natural Cp. abortus in...

  6. Ovine Enzootic Abortion (OEA): a comparison of antibody responses in vaccinated and naturally-infected swiss sheep over a two year period

    Zimmermann Dieter R; Doherr Marcus G; Kaiser Carmen; Psarrou Evgenia; Vretou Evangelia; Thoma Ruedi; Gerber Andrea; Polkinghorne Adam; Pospischil Andreas; Borel Nicole

    2007-01-01

    Abstract Background Prevention and control of ovine enzootic abortion (OEA) can be achieved by application of a live vaccine. In this study, five sheep flocks with different vaccination and infection status were serologically tested using a competitive enzyme-linked immunosorbent assay (cELISA) specific for Chlamydophila (Cp.) abortus over a two-year time period. Results Sheep in Flock A with recent OEA history had high antibody values after vaccination similar to Flock C with natural Cp. abo...

  7. Abortion and Selection

    Elizabeth Oltmans Ananat; Jonathan Gruber; Phillip B. Levine; Douglas Staiger

    2006-01-01

    The introduction of legalized abortion in the early 1970s led to dramatic changes in fertility behavior. Some research has suggested as well that there were important impacts on cohort outcomes, but this literature has been limited and controversial. In this paper, we provide a framework for understanding the mechanisms through which abortion access affects cohort outcomes, and use that framework to both address inconsistent past methodological approaches, and provide evidence on the long-run...

  8. The abortion debate in Australia.

    Read, Christine Margaret

    2006-09-01

    I recently watched a fascinating documentary about the crusade of Dr Bertram Wainer in the 1960s to bring the practice of illegal abortion in Victoria to an end. It documented the profound horror of the backyard abortion that so often ended in infection, sterility or death, and served as a potent reminder of a practice to which we must never return. Of course that cant happen again, abortion is legal now, isnt it? In Victoria in 1969 a Supreme Court judge ruled that an abortion is not unlawful if a doctor believed that: the abortion is necessary to preserve the woman from serious danger to her life or physical or mental health (Menhennit ruling). In Australia today however, abortion law remains conditional, unclear and inconsistent and, except in the ACT, is still part of criminal statutes. PMID:16969440

  9. Abortive phage-infection and UV-protection markers on ColI plasmids from epidemic strains of Salmonella

    Cultures of Escherichia coli carrying ColI plasmids received in conjugation from strains of Salmonella typhimurium and S. agona were examined for abortive infection (Abi) of phage BF23 and for enhanced resistance to the lethal action of UV-irradiation (Uvr). The Abi character of stored cultures of E. coli was also compared with the reaction of the same stock culture tested 5 years before. Seven of the eight potential types differentiated by three characters were represented among 160 ColI plasmids: ColIa Abi+ Uvr+ (3 plasmids), ColIa Abi- Uvr+ (1), ColIa Abi- Uvr-> (2), ColIb Abi+ Uvr+ (85), ColIb Abi+ Uvr- (5), ColIb Abi- Uvr+ (4), ColIb Abi-? Uvr- (60). Recognition that different plasmid types could be carried by strains of a clone proved useful in the interpretation of the epidemic spread of strains of S. typhimurium of phage type/biotype 141/9f in Scotland and in tracing the ancestry of a recently emerged rhamnose non-fermenting mutant strain of S. agona. (author)

  10. Haemophilus influenzae Septic Abortion

    Sharon L. Hillier

    2002-01-01

    Full Text Available Background: Haemophilus influenzae septic abortion is typically caused by nontypeable strains of the organism. Furthermore, nontypeable species with a special affinity for the genital tract are the most frequent isolates encountered, and an ascending vaginal or cervical infection is often the suspected route of transmission.

  11. Detection of porcine circovirus genotypes 2a and 2b in aborted foetuses from infected swine herds in the State of São Paulo, Brazil

    de Castro Alessandra MMG; Cruz Taís F; Salgado Vanessa R; Kanashiro Tatiana M; Ferrari Karen L; Araujo João P; Brandão Paulo E; Richtzenhain Leonardo J

    2012-01-01

    Abstract Background Porcine circovirus type 2 (PCV2) has been associated with several disease complexes, including reproductive failure. The aim of this study was to identify the subtypes of PCV2 that are associated with reproductive failure in pigs from the State of São Paulo, Brazil and to investigate co-infections with other infectious organisms. Findings Samples of 168 aborted foetuses or mummified foetuses from five farrow-to-finish swine farms known to be infected with PCV2 and located ...

  12. Mechanism of human rhinovirus infections.

    Blaas, Dieter; Fuchs, Renate

    2016-12-01

    About 150 human rhinovirus serotypes are responsible for more than 50 % of recurrent upper respiratory infections. Despite having similar 3D structures, some bind members of the low-density lipoprotein receptor family, some ICAM-1, and some use CDHR3 for host cell infection. This is also reflected in the pathways exploited for cellular entry. We found that even rhinovirus serotypes binding the same receptor can travel along different endocytic pathways and release their RNA genome into the cytosol at different locations. How this may account for distinct immune responses elicited by various rhinoviruses and the observed symptoms of the common cold is briefly discussed. PMID:27251607

  13. Up Regulation of the Maternal Immune Response in the Placenta of Cattle Naturally Infected with Neospora caninum

    Rosbottom, Anne; Gibney, Helen; Kaiser, Peter; Hartley, Catherine; Smith, Robert F.; Robinson, Rebecca; Kipar, Anja; Williams, Diana J. L.

    2011-01-01

    Neospora caninum is an intracellular protozoan parasite which is a major cause of abortion in cattle worldwide. It forms persistent infections which recrudesce during pregnancy leading to foetal infection and in a proportion of cases, abortion. The mechanisms underlying abortion are not understood. In this study, recrudescence of a persistent infection in eight naturally infected cows occurred between 20 and 33 weeks of gestation. Animals were killed at the time of recrudescence and parasites...

  14. Epstein-Barr virus infection mechanisms

    Liudmila S. Chesnokova; Lindsey M. Hutt-Fletcher

    2014-01-01

    Epstein-Barr virus (EBV) infection occurs by distinct mechanisms across different cell types. EBV infection of B cellsin vitro minimally requires 5 viral glycoproteins and 2 cellular proteins. By contrast, infection of epithelial cells requires a minimum of 3 viral glycoproteins, which are capable of interacting with one or more of 3 different celular proteins. The ful complement of proteins involved in entry into al cel types capable of being infectedin vivo is unknown. This review discusses the events that occur when the virus is delivered into the cytoplasm of a cel, the players known to be involved in these events, and the ways in which these players are thought to function.

  15. High prevalence of unwanted pregnancies and induced abortions among HIV-infected women from Western India: need to emphasize dual method use?

    Darak, Shrinivas; Hutter, Inge; Kulkarni, Vinay; Kulkarni, Sanjeevani; Janssen, Fanny

    2016-01-01

    This study examines the prevalence, reasons, and predictors of unwanted pregnancies and induced abortions among ever married HIV-infected women attending a care facility in Maharashtra, Western India, and discusses its programmatic and policy implications. Retrospectively collected data of pregnancies conceived after the diagnosis of HIV were analyzed using descriptive and logistic regression techniques. Among the 622 women interviewed, 113 women had 158 pregnancies with known outcomes after HIV diagnosis. Among these pregnancies, 80 (51%) were unwanted and 79 (50%) were voluntarily terminated. Fear of transmitting HIV to the child was a frequently mentioned reason for an unwanted pregnancy (71.8%) and induced abortion (59.5%). Women from urban areas [OR 2.43 (95% CI 1.23-4.79)] and with two or more live births before HIV diagnosis [OR 3.33 (95% CI 1.36-8.20)] were significantly more likely to report an unwanted pregnancy. Women with two or more live births before HIV diagnosis [OR 3.16 (95% CI 1.20-8.35)], who did not know that HIV transmission to the baby can be prevented [OR 3.29 (95% CI 1.48-7.34)] and with an unwanted pregnancy [OR 4.82 (95% CI 2.33-10.00)], were significantly more likely to terminate the pregnancy. Despite increased coverage of antiretroviral treatment, effective provision of reproductive healthcare services to HIV-infected women remains challenging. A high prevalence of unwanted pregnancies and induced abortions and a low level of knowledge about prevention of mother to child transmission (PMTCT) underscore the need for preconception counseling and provision of comprehensive family planning services to HIV-infected women. Enrolling all HIV-infected pregnant women, irrespective of their decision to continue with their pregnancy, in the PMTCT program and discussing with HIV-infected women and their partners at HIV diagnosis a full array of contraceptive methods and not just consistent use of condoms might be helpful in reducing unwanted

  16. Dual congenital transmission of Toxoplasma gondii and Sarcocystis neurona in a late-term aborted pup from a chronically infected southern sea otter (Enhydra lutris nereis).

    Shapiro, Karen; Miller, Melissa A; Packham, Andrea E; Aguilar, Beatriz; Conrad, Patricia A; Vanwormer, Elizabeth; Murray, Michael J

    2016-03-01

    Toxoplasma gondii and Sarcocystis neurona are protozoan parasites with terrestrial definitive hosts, and both pathogens can cause fatal disease in a wide range of marine animals. Close monitoring of threatened southern sea otters (Enhydra lutris nereis) in California allowed for the diagnosis of dual transplacental transmission of T. gondii and S. neurona in a wild female otter that was chronically infected with both parasites. Congenital infection resulted in late-term abortion due to disseminated toxoplasmosis. Toxoplasma gondii and S. neurona DNA was amplified from placental tissue culture, as well as from fetal lung tissue. Molecular characterization of T. gondii revealed a Type X genotype in isolates derived from placenta and fetal brain, as well as in all tested fetal organs (brain, lung, spleen, liver and thymus). This report provides the first evidence for transplacental transmission of T. gondii in a chronically infected wild sea otter, and the first molecular and immunohistochemical confirmation of concurrent transplacental transmission of T. gondii and S. neurona in any species. Repeated fetal and/or neonatal losses in the sea otter dam also suggested that T. gondii has the potential to reduce fecundity in chronically infected marine mammals through parasite recrudescence and repeated fetal infection. PMID:26494610

  17. Immune mechanisms in Babesia-infected animals

    The course of a Babesia infection depends on the species of host and parasite involved. Animals infected with virulent babesias may need chemotherapy before acquired immunity develops. Maintenance of immunity is not dependent on the presence of the parasite. Babesia infections are characteristically of long duration. The immune response to babesias includes both humoral and cellular components. Antibody levels detected in serodiagnostic tests do not relate to levels of resistance to the parasite. Some antibodies, however, appear to be protective. Antiparasitic antibodies may damage parasites in or outside the red cell and act as opsonins. T-cell-deficient and anti-lymphocyte-serum-treated rodents are more susceptible to rodent piroplasms indicating a role for T-cells as either helper cells and/or as mediators of cell-mediated immunity (CMI). There is indirect evidence of CMI, but the cell-mediated mechanisms involved in parasite killing are not known. In domestic animals immunity is largely species- and strain-specific. Antigenic variation by babesias occurs. In rodents, however, there is cross-immunity between different species of rodent piroplasms and between rodent piroplasms and some malaria parasites. Prior infection with agents such as BCG, and Corynebacterium parvum, gives mice non-specific resistance to rodent piroplasms possibly mediated through a soluble non-antibody factor. This factor may also be liberated during piroplasm infections and by being toxic to malaria parasites account for heterologous immunity. Active immunization against babesias has been achieved with avirulent strains, irradiated parasites and dead parasites in adjuvant. During Babesia infections the primary and, to a lesser degree, the secondary immune response to heterologous antigens can be depressed. Maximum depression coincides with peak parasitaemia when antigen priming may be abolished completely. Immunosuppression during Babesia infections can prolong or exacerbate concurrent

  18. Ovine Enzootic Abortion (OEA: a comparison of antibody responses in vaccinated and naturally-infected swiss sheep over a two year period

    Zimmermann Dieter R

    2007-09-01

    Full Text Available Abstract Background Prevention and control of ovine enzootic abortion (OEA can be achieved by application of a live vaccine. In this study, five sheep flocks with different vaccination and infection status were serologically tested using a competitive enzyme-linked immunosorbent assay (cELISA specific for Chlamydophila (Cp. abortus over a two-year time period. Results Sheep in Flock A with recent OEA history had high antibody values after vaccination similar to Flock C with natural Cp. abortus infections. In contrast, OEA serology negative sheep (Flock E showed individual animal-specific immunoreactions after vaccination. Antibody levels of vaccinated ewes in Flock B ranged from negative to positive two and three years after vaccination, respectively. Positive antibody values in the negative control Flock D (without OEA or vaccination are probably due to asymptomatic intestinal infections with Cp. abortus. Excretion of the attenuated strain of Cp. abortus used in the live vaccine through the eye was not observed in vaccinated animals of Flock E. Conclusion The findings of our study indicate that, using serology, no distinction can be made between vaccinated and naturally infected sheep. As a result, confirmation of a negative OEA status in vaccinated animals by serology cannot be determined.

  19. Immunologically mediated abortion (IMA).

    Giacomucci, E; Bulletti, C; Polli, V; Prefetto, R A; Flamigni, C

    1994-06-01

    Roughly 20% of all clinical pregnancies evolve into "spontaneous abortions". The causes of spontaneous abortion have been determined in under 60% of the total and comprise genetic, infectious, hormonal and immunological factors. In some cases the immune tolerance mechanism may be impaired and the foetus immunologically rejected (IMA, immunologically mediated abortion). The immunological mechanism implicated depends on the time in which pregnancy loss takes place. During preimplantation and up to the end of implantation (13th day) the cell-mediated immune mechanism (potential alloimmune etiologies) is responsible for early abortion. This mechanism involves immunocompetent decidual cells (eGL, endometrial granulated lymphocytes) already present during pre-decidualization (late luteal phase) and their production of soluble factors or cytokines. Once the implantation process is over, after blastocyst penetration of the stroma and the decidual reaction of uterine tissue, IMA could be caused by cell-mediated and humoral mechanism (anti-paternal cytotoxic antibodies or autoantibody etiology), by the production of paternal anti major histocompatibility complex antibodies, or even by an autoimmune disorder leading to the production of autoantibodies (antiphospholipid antibodies, antinuclear antibodies or polyclonal B cell activation). The diagnostic work-up adopted to select IMA patients is crucial and includes primary (karyotype of both partners, toxo-test, hysterosalpingography, endometrial biopsy, thyroid function tests, serum hprolactin, luteal phase dating) and secondary (full hemochromocytometric test, search for LE cells, lupus anticoagulant, anticardiolipin, antinuclear antibodies, Rheumatoid factor, blood complement VDRL) investigations. Therapeutical approaches vary. If autoimmune disorders are demonstrated therapies with different combinations of corticosteroids, aspirin and heparin or intravenous immunoglobulin are administered. Otherwise, therapy with paternal

  20. INFLUENCE OF ELECTROACUPUNCTURE ON ARTIFICIAL ABORTION-INDUCED SIDE EFFECTS

    田丽颖

    2001-01-01

    In the present study, the effect of electroecupuncture (EA) of acupoints of Ren, Spleen and Stomach Meridians on artificial abortion-induced side effects was observed in 100 artificial abortion women. In comparison with 45 artificial abortion women in the control group (who had not accepted EA treatment), EA possessed significant effects in relieving abdominal pain, reducing vaginal bleeding duration, lowering infection rate and infertility rate after artificial abortion operation.

  1. A survey of the incidence of Neospora caninum infection in aborted and stillborn bovine fetuses in England and Wales.

    Otter, A; Jeffrey, M; Griffiths, I B; Dubey, J P

    1995-06-17

    Selected brains and fetal viscera from 190 aborted or stillborn bovine fetuses submitted to Veterinary Investigation Centres in England and Wales between August 1992 and January 1993 were examined histologically. Non-suppurative inflammation of the brain and/or myocardium and placental cotyledons was identified by light microscopy in 20 (10.5 per cent). An immunocytochemical examination of fixed tissue sections using antisera against Neospora caninum, Toxoplasma gondii and Sarcocystis species revealed positive immunolabelling for N caninum in the brains of eight (4.2 per cent), but no labelling with anti-T gondii or anti-Sarcocystis species antisera was evident. These results suggest that N caninum may be an important cause of reproductive failure in cattle in England and Wales. PMID:7571263

  2. Mechanisms of infection in the respiratory tract.

    Baskerville, A

    1981-12-01

    Related to its potential vulnerability the respiratory tract has a very complex and effective defence apparatus. The interaction between these defence mechanisms and certain characteristics of aetiological agents results in a pattern in which initial infections by these agents tend to occur at specific sites in the tract. Infections in which the primary portal of entry is in the upper respiratory tract include Bordetella bronchiseptica and Haemophilus spp in pigs; Pasteurella spp in cattle, sheep, pigs; Mycoplasma spp in cattle, sheep, pigs and poultry; equine herpesvirus 1 in horses; infectious bovine rhinotracheitis in cattle; parainfluenza 3 in cattle and sheep; infectious laryngo-tracheitis and infectious bronchitis in poultry; feline viral rhinotracheitis and calicivirus in cats; Aujeszky's disease virus and swine influenza in pigs; and equine influenza in horses. Infections in which the primary portal of entry is in the lower respiratory tract include Aspergillus fumigatus in poultry and mammals, respiratory syncytial virus in cattle, distemper virus in dogs and adenovirus in cattle and dogs. A fuller understanding of the interactions between an agent and the host at the point of entry would make it much easier to develop effective vaccines and therapeutic agents. PMID:16030806

  3. Conceptualising abortion stigma

    A. Kumar; L. Hessini; E.M.H. Mitchell

    2009-01-01

    Abortion stigma is widely acknowledged in many countries, but poorly theorised. Although media accounts often evoke abortion stigma as a universal social fact, we suggest that the social production of abortion stigma is profoundly local. Abortion stigma is neither natural nor 'essential' and relies

  4. Space Shuttle ascent aborts

    Schmidgall, Richard A.

    1989-09-01

    Specific guidance functions and trajectory design of return to launch site (RTLS) and transoceanic abort landing (TAL) intact abort profiles, as well as the increasing emphasis on contingency aborts, are presented. Various systems failures including Space Shuttle main engine failures and detailed technical analyses, including the design of powered flight abort trajectories, are considered. The most critical of flight abort situations is the RTLS, while TAL is the preferred abort when uphill capability is no longer available. It is concluded that one principle must remain to ensure continuing success of Space Shuttle flights: namely that intact and contingency aborts necessitate development to ensure safe return of the vehicle, payload, and crew whenever possible.

  5. Determination of Seropositivity for Toxoplasma gondiiInfection in Pregnant and Aborted Sheep in Elazig and Vicinity by Sabin-Feldman (SF) Test

    AKTAŞ, Münir; DUMANLI, Nazir

    2000-01-01

    This study was conducted in pregnant and aborted sheep to determine Toxoplasma gondiiantibodies. Blood samples were collected from a total of 154 sheep from 22 different herds during the period December 1996-January 1997 in Elazig and vicinity. Of these 154 sheep, 56 were pregnant, 57 aborted in the previous year and the remaining 41 sheep aborted within the period of the study. Sera obtained properly from these blood samples were examined by Sabine-Feldman (SF) test. Seropositivity for T...

  6. Should abortion be legalized?

    Sodhy, L S

    1968-01-01

    Abortion is an important means of family planning, especially when contraception is unavailable or when it fails. Morbidity associated with legal abortion is low, though illegal abortion is a common cause of maternal mortality. The Union of Soviet Socialist Republic, Hungary, Yugoslavia, Czechoslovakia, Romania, Poland, and the German Demogratic Republic all have laws legalizing abortion. Legalized abortion is the surest method of population control and should be promoted if the moral and religious objections can be overcome. PMID:12255647

  7. Abortion Before & After Roe

    Joyce, Ted; Tan, Ruoding; Zhang, Yuxiu

    2013-01-01

    We use unique data on abortions performed in New York State from 1971–1975 to demonstrate that women travelled hundreds of miles for a legal abortion before Roe. A100- mile increase in distance for women who live approximately 183 miles from New York was associated with a decline in abortion rates of 12.2 percent whereas the same change for women who lived 830 miles from New York lowered abortion rates by 3.3 percent. The abortion rates of nonwhites were more sensitive to distance than those of whites. We found a positive and robust association between distance to the nearest abortion provider and teen birth rates but less consistent estimates for other ages. Our results suggest that even if some states lost all abortion providers due to legislative policies, the impact on population measures of birth and abortion rates would be small as most women would travel to states with abortion services. PMID:23811233

  8. Effect of heat preservation infusion on incidence of infection for patients after artificial abortion%人工流产后感染患者应用保温输液的效果评价

    王瑜玲; 王健平; 黄彬寿; 曾军荣; 刘敏鸿; 黄燕莺

    2013-01-01

    Objective To observe the control effect of heat preservation infusion on incidence of infection after artificial abortion.Methods 168 cases of patients after artificial abortion were randomly divided into the heat preservation infusion group and normal infusion group with 84 cases in each group.The normal infusion group received routine nursing,and was intravenously infused fluid with non heat preservation method,the heat preservation infusion group was intravenously infused constant temperature liquid heated to 37℃.The incidence of infection was observed in two groups of patients after artificial abortion.Results The infection rate of the heat preservation group was significantly less than the normal infusion group.Conclusions Heat preservation infusion can effectively reduce the infection rate after artificial abortion.%目的 观察保温输液对人工流产后感染状况的控制效果.方法 将168例人工流产患者随机分为保温输液组和常温输液组各84例.常温输液组采用常规护理,用非保温方式静脉输入室温液体,保温输液组输入恒温加热至37℃的液体,观察2组患者人工流产术后感染的发生情况.结果 保温输液组流产后感染发生率显著低于常温输液组.结论 保温输液能有效降低人工流产后的感染率.

  9. 复发性流产与宫颈HPV感染的相关性分析%Correlation Analysis of HPV Infection and Pregnancy Recurrent Spontaneous Abortions

    钟小敏

    2015-01-01

    目的:探讨复发性流产与宫颈HPV感染的相关性。方法:将本站妇科门诊就诊的早期复发性流产(RSA)98例患者作为实验组,同时期妊娠的非RSA女性95例为对照组,采用PCR法对两组患者进行宫颈HPV基因检测,对比两组患者HPV感染的阳性率及各亚型在HPV感染中的比例。结果:实验组中HPV阳性34例(34.7%),对照组HPV阳性12例(12.6%),实验组HPV阳性率显著高于对照组(χ2=16.186, P0.05);HPV阳性与RSA发生呈正相关性(r=0.259,P0.05).There was significant positive correlation between HPV-positive and RSA occur (r=0.259,P<0.001).Conclusion:Early pregnancy recurrent spontaneous abortions is associated with HPV infection closely, HPV may be involved in the occurrence of RSA.

  10. Disturbances of electrodynamic activity affect abortion in human

    Biochemical research of biological systems is highly developed, and it has disclosed a spectrum of chemical reactions, genetic processes, and the pathological development of various diseases. The fundamental hypothesis of physical processes in biological systems, in particular of coherent electrically polar vibrations and electromagnetic activity, was formulated by H. Fröhlich; he assumed connection of cancer process with degradation of coherent electromagnetic activity. But the questions of cellular structures capable of the coherent electrical polar oscillation, mechanisms of energy supply, and the specific role of the endogenous electromagnetic fields in transport, organisation, interactions, and information transfer remained open. The nature of physical disturbances caused by some diseases (including the recurrent abortion in humans and the cancer) was unknown. We have studied the reasons of recurrent abortions in humans by means of the cell mediated immunity (using immunologic active RNA prepared from blood of inbred laboratory mice strain C3H/H2K, infected with the lactate dehydrogenase elevating virus-LD V) and the cytogenetic examination from karyotype pictures. The recurrent abortion group contained women with dg. spontaneous abortion (n = 24) and the control group was composed of 30 healthy pregnant women. Our hypothesis was related to quality of endometrium in relation to nidation of the blastocyst. The energetic insufficiency (ATP) inhibits normal development of fetus and placenta. We hope that these ideas might have impact on further research, which could provide background for effective interdisciplinary cooperation of malignant and non-malignant diseases.

  11. Disturbances of electrodynamic activity affect abortion in human

    Jandová, A.; Nedbalová, M.; Kobilková, J.; Čoček, A.; Dohnalová, A.; Cifra, M.; Pokorný, J.

    2011-12-01

    Biochemical research of biological systems is highly developed, and it has disclosed a spectrum of chemical reactions, genetic processes, and the pathological development of various diseases. The fundamental hypothesis of physical processes in biological systems, in particular of coherent electrically polar vibrations and electromagnetic activity, was formulated by H. Fröhlich he assumed connection of cancer process with degradation of coherent electromagnetic activity. But the questions of cellular structures capable of the coherent electrical polar oscillation, mechanisms of energy supply, and the specific role of the endogenous electromagnetic fields in transport, organisation, interactions, and information transfer remained open. The nature of physical disturbances caused by some diseases (including the recurrent abortion in humans and the cancer) was unknown. We have studied the reasons of recurrent abortions in humans by means of the cell mediated immunity (using immunologic active RNA prepared from blood of inbred laboratory mice strain C3H/H2K, infected with the lactate dehydrogenase elevating virus-LD V) and the cytogenetic examination from karyotype pictures. The recurrent abortion group contained women with dg. spontaneous abortion (n = 24) and the control group was composed of 30 healthy pregnant women. Our hypothesis was related to quality of endometrium in relation to nidation of the blastocyst. The energetic insufficiency (ATP) inhibits normal development of fetus and placenta. We hope that these ideas might have impact on further research, which could provide background for effective interdisciplinary cooperation of malignant and non-malignant diseases.

  12. The abortion debate in South Africa.

    Rees, H

    1991-01-01

    Before 1975 abortion was illegal in South Africa unless the life of the mother was at risk. The Abortion and Sterilization Act (ASA) of 1975 broadened the scope of legal abortion. The act allows abortion to save the life of the mother, in cases of severe fetal deformity, in cases or rape or incest, or if the woman is mentally incompetent. The procedure to get the abortion includes finding a doctor to recommend the procedure, then finding 2 other doctors to claim, in good faith, that abortion is indicated. At least 1 of these doctors must have been practicing for 4 years and neither can participate in the procedure. The operation must take place in a state controlled institution or an institution specifically designed for abortion. This law is currently not serving the needs of the women of South Africa, even among the women who are legally entitled to have an abortion. Annually only 40% of those that apply for abortion are approved and over 70% of the approved procedures are performed on psychological grounds. It is estimated that there are 200,000-300,000 illegal abortions every year. At Baragwanath there are 15,000 patients admitted for infection related to abortion every year. The ASA has failed to stop illegal abortion and failed to meet the needs of society. The abortion law should be liberalized for a variety of reasons. Women do not have adequate access to contraceptives in South Africa. This results in the birth of many unwanted children which are more likely to be abused and abandoned. Even if contraceptives were universally available, they all have associated failure rates. Since it is assumed that a women using contraceptives does not want to become pregnant, abortion needs to be available as a backup to contraceptives. Since South Africa is a patriarchal society, women must be given control over their reproduction if they are to achieve equal status. Thus for the reasons of preventing unwanted and unwanted and abused children, backing up contraceptives

  13. Helminth infections induce immunomodulation: consequences and mechanisms

    Riet, Petronella Helena van

    2008-01-01

    Worldwide, more than a billion people are infected with helminths. These worm infections are chronic in nature and can lead to considerable morbidity. Immunologically these infections are interesting; chronic helminth infections are characterized by skewing towards a T helper 2 type response as well as regulatory responses. The latter is thought to prevent strong immune responses against parasitic worms, allowing their long-term survival and restricting pathology. This regulatory network is t...

  14. Abortion and psychiatric practice.

    Stotland, Nada L

    2003-03-01

    The subject of abortion is fraught with politics, emotions, and misinformation. A widespread practice reaching far back in history, abortion is again in the news. Psychiatry sits at the intersection of the religious, ethical, psychological, sociological, medical, and legal facets of the abortion issue. Although the religions that forbid abortion are more prominent in the media, many religions have more liberal approaches. While the basic right to abortion has been upheld by the U.S. Supreme Court, several limitations have been permitted, including parental notification or consent (with the possibility of judicial bypass) for minors, waiting periods, and mandatory provision of certain, sometimes biased, information. Before the Roe v. Wade decision legalizing abortion in 1973, many women were maimed or killed by illegal abortions, and psychiatrists were sometimes asked to certify that abortions were justified on psychiatric grounds. Currently, there are active attempts to convince the public and women considering abortion that abortion frequently has negative psychiatric consequences. This assertion is not borne out by the literature: the vast majority of women tolerate abortion without psychiatric sequelae. The psychiatric outcome of abortion is best when patients are able to make autonomous, supported decisions. Psychiatrists need to know the medical and psychiatric facts about abortion. Psychiatrists can then help patients prevent unwanted pregnancies, make informed decisions consonant with their own values and circumstances when they become pregnant, and find appropriate social and medical resources whatever their decisions may be. PMID:15985924

  15. Diagnostic studies of abortion in Danish dairy herds

    Agerholm, J.S.; Willadsen, C. M.; Nielsen, Thomas Krogh; Giese, Steen Bjørck; Holm, Elisabeth; Jensen, L.; Agger, J. F.

    Diagnostic findings in 218 aborted bovine foetuses are reported. The materials were examined in a matched case-control study of 69 Danish dairy herds with a sudden increase in the number of abortions and a corresponding 69 control herds. Foetuses aborted during the subsequent 6-month period were...... examined to identify the cause of abortion if possible. A total of 186 specimens were submitted from case herds and 32 from control herds. A likely cause of abortion was diagnosed in 73 foetuses. The most common cause was bovine viral diarrhoea virus (BVDV: 13%) followed by Neospora caninum infection (10......%), mycosis (5%) and Bacillus licheniformis infection (4%). Foetal and/or placental lesions were found in a further 27 cases. Only BVDV infection and neosporosis were diagnosed in more than one foetus per herd and only protozoal associated abortions occurred significantly more frequently in the case, rather...

  16. Bills to decriminalize abortion in Brazil.

    1994-01-01

    The National Congress in Brazil is currently considering 9 abortion bills, 2 of which were introduced by women. In this interview, the women senators--Jandira Feghall of the Communist Party and Eva Blay of the Social Democrat Party--discuss the likely outcome of the abortion debate. Although the Roman Catholic Church has announced its intentions to oppose any liberalization of the abortion law, there are divisions within the Church as evidenced by the existence of groups such as Catholics for a Free Choice. Both senators agree that decriminalization of abortion will depend upon the societal response and an effort must be made to reach the many people who are confused and undecided about the issue. Although the present debate fits within the broader current debate on population policies, it has been the insistence of the feminist movement that put abortion reform on the agenda. Blay's bill calls for the legalization of abortion on demand until the 12th week of pregnancy and in cases of rape or risk to the woman's life after that point. A controversial aspect of Feghall's bill is the inclusion of maternal human immunodeficiency virus (HIV) infection as a condition for abortion. Feghall notes that this is an option rather than a requirement, but she will eliminate this condition if it engenders discrimination against HIV-infected women. PMID:12318722

  17. Legalized abortion in Czechoslovakia.

    Zidovsky, J; Zwinger, A

    1972-01-01

    A law legalizing abortion was passed nearly 20 years ago in Czechosl ovakia. The law aimed to give women the freedom to decide for themselves whether they want to be pregnant and to decrease the dangers of illegal abortion. The law resulted in a decreased number of abortions and of complications and deaths associated with abortion. Fertility in the country also declined. In 1968 there were more abortions than live births in the country. Since 1957, the law has been modified. The law still aims to prevent the birth of defective children and to protect the life and health of mothers. Each application for abortion is now examined on its own merits. Favorable economic circumstances, prolife social policies adopted by the government, and the new stricter interpretation of the abortion law have resulted in a r ising birthrate since 1969. Contraception is still stressed as preferab le to abortion. PMID:12256872

  18. Abortion - surgical - aftercare

    ... this page: //medlineplus.gov/ency/patientinstructions/000658.htm Abortion - surgical - aftercare To use the sharing features on ... please enable JavaScript. You have had a surgical abortion. This is a procedure that ends pregnancy by ...

  19. Kinetics of Infection and Effects on Placental Cell Populations in a Murine Model of Chlamydia psittaci-Induced Abortion

    Buendía, Antonio J.; Sánchez, Joaquín; Martínez, María C.; Cámara, Paulina; Navarro, Jose A.; Rodolakis, Annie; Salinas, Jesus

    1998-01-01

    The anatomical progression of chlamydial infection was studied in different areas of the placenta, using a mouse model and two inoculation times: early pregnancy (day 7, group A) and midpregnancy (day 11, group B). The first population cells affected were decidual cells and neutrophils located just at the limits of the maternal and fetal placenta. The following invaded area was the layer of giant cells. Complete colonization of the maternal placenta occurred after day 15 of pregnancy independ...

  20. Abortion among Adolescents.

    Adler, Nancy E.; Ozer, Emily J.; Tschann, Jeanne

    2003-01-01

    Reviews the current status of abortion laws pertaining to adolescents worldwide, examining questions raised by parental consent laws in the United States and by the relevant psychological research (risk of harm from abortion, informed consent, consequences of parental involvement in the abortion decision, and current debate). Discusses issues…

  1. Late-term abortion.

    Epner, J E; Jonas, H S; Seckinger, D L

    1998-08-26

    Recent proposed federal legislation banning certain abortion procedures, particularly intact dilatation and extraction, would modify the US Criminal Code such that physicians performing these procedures would be liable for monetary and statutory damages. Clarification of medical procedures is important because some of the procedures used to induce abortion prior to viability are identical or similar to postviability procedures. This article reviews the scientific and medical information on late-term abortion and late-term abortion techniques and includes data on the prevalence of late-term abortion, abortion-related mortality and morbidity rates, and legal issues regarding fetal viability and the balance of maternal and fetal interests. According to enacted American Medical Association (AMA) policy, the use of appropriate medical terminology is critical in defining late-term abortion procedures, particularly intact dilatation and extraction, which is a variant of but distinct from dilatation and evacuation. The AMA recommends that the intact dilatation and extraction procedure not be used unless alternative procedures pose materially greater risk to the woman and that abortions not be performed in the third trimester except in cases of serious fetal anomalies incompatible with life. Major medical societies are urged to collaborate on clinical guidelines on late-term abortion techniques and circumstances that conform to standards of good medical practice. More research on the advantages and disadvantages of specific abortion procedures would help physicians make informed choices about specific abortion procedures. Expanded ongoing data surveillance systems estimating the prevalence of abortion are also needed. PMID:9728645

  2. 57.1% of Unmarried Women Undergoing Abortion Have RTI:Survey

    2004-01-01

    A survey of 2,002 unmarried women under 24 years of age who requested abortions in four Chinese cities indicates that reproductive tract infection (RTI) has become a major factor affecting the reproductive health of unmarried women having abortions.

  3. Urinary tract infections: epidemiology, mechanisms of infection and treatment options.

    Flores-Mireles, Ana L; Walker, Jennifer N; Caparon, Michael; Hultgren, Scott J

    2015-05-01

    Urinary tract infections (UTIs) are a severe public health problem and are caused by a range of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis and Staphylococcus saprophyticus. High recurrence rates and increasing antimicrobial resistance among uropathogens threaten to greatly increase the economic burden of these infections. In this Review, we discuss how basic science studies are elucidating the molecular details of the crosstalk that occurs at the host-pathogen interface, as well as the consequences of these interactions for the pathophysiology of UTIs. We also describe current efforts to translate this knowledge into new clinical treatments for UTIs. PMID:25853778

  4. Abortion in Ireland.

    Francome, C

    1992-08-22

    Substantial legal barriers to abortion persist in both the Irish Republic and Northern Ireland, despite growing popular support for abortion under certain conditions. A 1983 amendment to the republic's constitution guarantees the fetus the same right to life s the mother and bans the provision of information on abortion. Although a recent well publicized case of a pregnant, suicidal 14-year-old who travelled to England for an abortion resulted in an Irish Supreme Court ruling that abortion was acceptable in cases of "real and substantial risk" to a woman's life, uncertainty still surrounds the right to travel to England for the procedure. In Northern Ireland, the 1967 Abortion Act does not apply and abortions are denied even in cases of rape and incest. A total of 1766 women from Northern Ireland and 4158 from the republic travelled to England for abortions in 1991. Public opinion seems to have shifted toward support for less restrictive abortion laws, however. Whereas 80% of those surveyed in a 1980 Irish poll supported to ban on abortion in all cases, this statistic had dropped to 30% by 1990. Similarly, a 1991 poll taken in Northern Ireland found 80% of respondents to be a favor of abortion in cases where the procedure is necessary to maintain a woman's physical or mental health. PMID:1392954

  5. Q-feber som årsag til spontan abort

    Nielsen, Stine Yde; Mølbak, Kåre; Hjøllund, Niels Henrik

    2011-01-01

    Q-fever is a zoonotic infection. Pregnant women constitute a specific risk group as the infection may cause spontaneous abortion, intrauterine death, growth retardation, oligohydramnios and premature birth. A 39 year-old veterinarian had a spontaneous abortion in pregnancy week seven. During the...... first weeks of her pregnancy, she handled birth by-products from cows with Q-fever. The Q-fever titres revealed that she was most likely infected in very early pregnancy. According to the literature, infection in the first trimester constitutes a specific risk of spontaneous abortion....

  6. Trypsin enhancement of rotavirus infectivity: mechanism of enhancement.

    Clark, S M; Roth, J R; Clark, M L; Barnett, B B; Spendlove, R S

    1981-01-01

    The infectivity of most rotaviruses is enhanced by treatment with trypsin. We studied the mechanism of enhancement of examining the effect of trypsin on rotavirus infectivity, aggregation, early interactions with host cells, and structure. The results indicated that trypsin does not increase levels of infectious virus by dispersion of aggregates or affect the efficiency or rate of attachment of virus to cells. A fraction of virus that was not infections without trypsin treatment was found to ...

  7. Abort Gap Cleaning for LHC Run 2

    Uythoven, J; Bravin, E; Goddard, B; Hemelsoet, GH; Höfle, W; Jacquet, D; Kain, V; Mazzoni, S; Meddahi, M; Valuch, D

    2015-01-01

    To minimise the beam losses at the moment of an LHC beam dump the 3 μs long abort gap should contain as few particles as possible. Its population can be minimised by abort gap cleaning using the LHC transverse damper system. The LHC Run 1 experience is briefly recalled; changes foreseen for the LHC Run 2 are presented. They include improvements in the observation of the abort gap population and the mechanism to decide if cleaning is required, changes to the hardware of the transverse dampers to reduce the detrimental effect on the luminosity lifetime and proposed changes to the applied cleaning algorithms.

  8. Protective Immune Mechanisms in Helminth Infection

    Important insights have been gained in our understanding of how immune responses mediate resistance to helminths and control associated pathological responses. Although similar cells and cytokines are evoked in response to infection by helminths as diverse as nematodes and schistosomes, the componen...

  9. The moral significance of spontaneous abortion.

    Murphy, T F

    1985-01-01

    Spontaneous abortion is rarely addressed in moral evaluations of abortion. Indeed, 'abortion' is virtually always taken to mean only induced abortion. After a brief review of medical aspects of spontaneous abortion, I attempt to articulate the moral implications of spontaneous abortion for the two poles of the abortion debate, the strong pro-abortion and the strong anti-abortion positions. I claim that spontaneous abortion has no moral relevance for strict pro-abortion positions but that the ...

  10. 毛白杨花粉败育机制的研究%STUDY ON MECHANISM OF POLLEN ABORTION IN CHINESE WHITE POPLAR (\\%POPULUS TOMENTOSA\\% CARR.)

    康向阳

    2001-01-01

    从细胞遗传学角度较为系统地揭示了毛白杨花粉败育的机制,即主要是毛白杨异质性遗传基础与环境相互作用的结果。(1)在减数分裂中有数目不等的联合程度较差的单价体以及落后染色体出现,这种与异质性相关的染色体行为异常,导致同源染色体向子细胞的不均衡分配,造成具功能染色体的缺失,从而引起毛白杨一定比率的败育花粉的产生;(2)遗传上的不平衡与温度等环境因子相互作用,进一步引发毛白杨生理乃至结构上的不平衡,花粉母细胞(或孢原细胞)和绒毡层细胞发育异常,从而造成不产粉或产粉较少;环境与基因型互作的差异性导致了花粉败育的年度不稳定性。(3)易位、倒位等染色体结构变异和天然三倍体株系的存在也是造成毛白杨花粉败育的原因。%The mechanism of pollen abortion in Chinese white poplar was revealed systematically from the observation of cytogenetics in this paper,that is,principally,resulted from interactions between environment and genetic heterogenetic basis of the species.(1)Unequal number of univalents with decreased degree of synapsis and lagging chromosomes occurred in meiosis.The abnormal chromosomal behavior correlated with heterogenicity gave rise to unequal allocation of homogenous chromosomes to daughter cells and resulted in the deletion of functional chromosoms,thus led to the occurence of a certion proportion of aborted pollens.(2)The interaction between genetic imbalance and such environmental factors as temperature,etc.,further drew forth physiological and even structrural imbalance,with abnormal development of pollen mother cells (orsporogonium) and tapetal cells,and consequently resulted in no or very few production of pollens.The difference in the interaction between environment and genotype reflected on the unstability of pollen abortion in different years.(3)The esistence of chromosome structrural

  11. [Abortion law in Italy].

    Havránek, F

    1979-04-01

    On May 28, 1978, the Italian senate passed a law legalizing abortions. The law, passed against the will of the Christian Democrat party and the Vatican, is the most liberal in Western Europe. Any woman 18 or older is free to seek an abortion at a private or public institution during the first 90 days of pregnancy. Abortions can be sought on health, economic, social, family, or psychological grounds. A woman requests an abortion at a hospital or clinic, or from a physician. If termination is deemed urgent, the procedure may be performed immediately. If a request is denied, a woman may make another request 7 days later. Second trimester abortions are permitted only if grave danger to the woman or deformation of the fetus is suspected. Women under 18 meed the permission of their parents or legal guardians; a court may also grant permission. Passage of the law has facilitated open debate on the legal and medical aspects of abortion. It has also guaranteed women access to abortions. Physicians, who on grounds of conscience feel they can't perform abortions, may register to be exempt from having to perform them. They may not, however, deny a woman care before and after her abortion, and if they perform the procedure even once, their name is removed from the exempt register. Additionally, all physicians are bound to attempt to preserve the life of all women as well as any fetus which shows life outside the womb. PMID:445601

  12. Pathogenic mechanisms in the development of surgical site infections

    Jovanović Zorica; Ilić Milena; Janković Slobodan

    2007-01-01

    Introduction. Surgical site infections represent a major problem in modern medicine. Bacterial survival and growth in surgical wounds depends on the effectiveness of the host defense mechanisms and on the ability of bacteria to resist these defensive mechanisms. Surgical site contamination causes cellular injury and triggers the inflammatory response. Host response to infection. An acute inflammatory response occurs within seconds to minutes of injury or invasion; it is non-specific and self-...

  13. Mechanisms of Zika Virus Infection and Neuropathogenesis.

    Olagnier, David; Muscolini, Michela; Coyne, Carolyn B; Diamond, Michael S; Hiscott, John

    2016-08-01

    A spotlight has been focused on the mosquito-borne Zika virus (ZIKV) because of its epidemic outbreak in Brazil and Latin America, as well as the severe neurological manifestations of microcephaly and Guillain-Barré syndrome associated with infection. In this review, we discuss the recent literature on ZIKV-host interactions, including new mechanistic insight concerning the basis of ZIKV-induced neuropathogenesis. PMID:27348136

  14. Induced abortion among Brazilian female sex workers: a qualitative study

    Alberto Pereira Madeiro

    2015-02-01

    Full Text Available Prostitutes are vulnerable to unplanned pregnancies and abortions. In Brazil, abortion is a crime and there is no data about unsafe abortions for this population. The study describes how prostitutes perform illegal abortions and the health consequences thereof. Semi-structured interviews with 39 prostitutes from three cities in Brazil with previous induced abortion experience were conducted. Sixty-six abortions, with between one and eight occurrences per woman, were recorded. The majority of the cases resulted from sexual activity with clients. The inconsistent use of condoms with regular clients and the consumption of alcohol during work were indicated as the main causes of unplanned pregnancies. The main method to perform abortion was the intravaginal and oral use of misoprostol, acquired in pharmacies or on the black market. Invasive measures were less frequently reported, however with more serious health complications. The fear of complaint to the police meant that most women do not inform the health team regarding induced abortion. The majority of prostitutes aborted with the use of illegally-acquired misoprostol, ending abortion in a public hospital with infection and hemorrhagic complications. The data indicate the need for a public policy focusing on the reproductive health of prostitutes.

  15. Induced abortion among Brazilian female sex workers: a qualitative study.

    Madeiro, Alberto Pereira; Diniz, Debora

    2015-02-01

    Prostitutes are vulnerable to unplanned pregnancies and abortions. In Brazil, abortion is a crime and there is no data about unsafe abortions for this population. The study describes how prostitutes perform illegal abortions and the health consequences thereof. Semi-structured interviews with 39 prostitutes from three cities in Brazil with previous induced abortion experience were conducted. Sixty-six abortions, with between one and eight occurrences per woman, were recorded. The majority of the cases resulted from sexual activity with clients. The inconsistent use of condoms with regular clients and the consumption of alcohol during work were indicated as the main causes of unplanned pregnancies. The main method to perform abortion was the intravaginal and oral use of misoprostol, acquired in pharmacies or on the black market. Invasive measures were less frequently reported, however with more serious health complications. The fear of complaint to the police meant that most women do not inform the health team regarding induced abortion. The majority of prostitutes aborted with the use of illegally-acquired misoprostol, ending abortion in a public hospital with infection and hemorrhagic complications. The data indicate the need for a public policy focusing on the reproductive health of prostitutes. PMID:25715152

  16. Cell mechanics and immune system link up to fight infections

    Ekpenyong, Andrew; Man, Si Ming; Tourlomousis, Panagiotis; Achouri, Sarra; Cammarota, Eugenia; Hughes, Katherine; Rizzo, Alessandro; Ng, Gilbert; Guck, Jochen; Bryant, Clare

    2015-03-01

    Infectious diseases, in which pathogens invade and colonize host cells, are responsible for one third of all mortality worldwide. Host cells use special proteins (immunoproteins) and other molecules to fight viral and bacterial invaders. The mechanisms by which immunoproteins enable cells to reduce bacterial loads and survive infections remain unclear. Moreover, during infections, some immunoproteins are known to alter the cytoskeleton, the structure that largely determines cellular mechanical properties. We therefore used an optical stretcher to measure the mechanical properties of primary immune cells (bone marrow derived macrophages) during bacterial infection. We found that macrophages become stiffer upon infection. Remarkably, macrophages lacking the immunoprotein, NLR-C4, lost the stiffening response to infection. This in vitro result correlates with our in vivo data whereby mice lacking NLR-C4 have more lesions and hence increased bacterial distribution and spread. Thus, the immune-protein-dependent increase in cell stiffness in response to bacterial infection (in vitro result) seems to have a functional role in the system level fight against pathogens (in vivo result). We will discuss how this functional link between cell mechanical properties and innate immunity, effected by actin polymerization, reduces the spread of infection.

  17. SEPTIC ABORTION: AN AVOIDABLE TRAGIC COMPLICATION

    Neelam

    2015-03-01

    Full Text Available Aim of this study was to study the incidence, demographic factors, clinical features, management, maternal morbidity, maternal mortality, surgical interventions with special emphasis on various contributing factors and unmet needs of septic abortion. In this study, 153 cases of septic abortions during six years periods, from January 2009 to December 2014 in the department of obstetrics and gynecology in Rajendra Institute of Medical Sciences, Ranchi, were included. All patients were evaluated with special reference to incidence, age incidence, marital status, socio economic status, residential distribution, gravida incidence, causes of septic abortion, grades of infection, clinical presentation, and management. Incidence of septic abortion was 3.88 % . Criminal interference was in 74 % of cases. Most of the cases (65 % were from low socioeconomic group. Sixty percent were from rural area. Fifty eight percent were tribal. Sixteen percent were admitted in septic shock. Laparotomy was required in seventeen percent of cases. Hysterectomy was require in five cases. Unfortunately, maternal death was nine. Cause of maternal death was septic shock in six and haemorrhagic shock in three. This incidence of septic abortion can be reduced by increasing awareness and making “safe abortion services” easily available, free of coast and also by providing family planning services.

  18. "Conservative" views of abortion.

    Devine, P E

    1997-01-01

    The introduction to this essay, which presents and defends the "conservative" position on abortion, explains that this position holds that 1) abortion is wrong because it destroys the fetus; 2) the fetus has full personhood from conception (or very near conception); 3) abortion is only justified under special circumstances, such as when the pregnancy poses a threat to the woman's life; and 4) these conclusions should be reflected in law and public policy. Part 2 sets forth the moral foundations for this position. The third part considers the status of the fetus and reviews the various arguments that have been forwarded to resolve the question, such as the species principle, the potentiality principle, the sentience principle, and the conventionalist principle. Part 4 applies the conservative position to problems posed by hard cases, determines that abortion is a form of homicide from two weeks after fertilization (at the latest), reviews circumstances in which various legal definitions of homicide are applicable, argues for the denial of abortion funding by the state, and notes that violent militancy is not the appropriate response to a belief that abortion should be illegal. Section 5 refutes objections to the conservative position based on the fact that some opponents of abortion also oppose contraception, based on feminist ideals, and based on calls for religious freedom in a pluralistic society. In conclusion, the labels applied to the abortion debate are examined, and it is suggested that "communitarian" is the best term for the conservative position. PMID:12348327

  19. Abortion in Adolescence.

    Campbell, Nancy B.; And Others

    1988-01-01

    Explored differences between 35 women who had abortions as teenagers and 36 women who had abortions as adults. Respondents reported on their premorbid psychiatric histories, the decision-making process itself, and postabortion distress symptoms. Antisocial and paranoid personality disorders, drug abuse, and psychotic delusions were significantly…

  20. Abortion in Zambia

    Coast, Ernestina; Freeman, Emily

    2015-01-01

    The poster, based on 112 in-depth interviews conducted in 2014 with women in Zambia who had recently had an abortion, shows the complex pathways that some women take despite safe abortion being legal under a wide range of circumstances in Zambia.

  1. Abortion: the new debate.

    Callahan, D

    1986-06-01

    The course of the debate on abortion following the 1973 Supreme Court decision legalizing abortion has been marked by a variety of medical and scientific developments. Many of these new developments have important legal, psychologic, social, moral, and political implications. The cumulative impact of all these developments may pose a significant challenge to the social and legal foundations of Roe v. Wade. PMID:3523563

  2. Access to legal abortion.

    1993-10-01

    Countries are grouped by the nature and extent of access to legal abortion. The categories include abortion on demand, for social reasons, for health reasons, for rape or incest or to save a mother's life, and only to save a mother's life. Abortion on demand is available for about 40% of the world's population and may have restrictions, such as parental consent or approval of state committees or physicians. There are 22 countries in Europe, 12 in the former Soviet Union, four in Asia, four in the Americas, one in the Middle East (Turkey), and one in Africa (Tunisia) which provide access to early abortion on demand. Abortion for social and economic reasons is available to 21% of the world's population in five countries in Asia, three in Europe (Great Britain, Finland, and Hungary), and one in Africa (Zambia). Abortion for health reasons is available to 16% of the world's population located in 21 countries in Africa, eight in the Americas, seven in Asia, five in Europe, and four in the Middle East. Laws governing about 5% of the world's population permit abortion only in the case of rape, incest, or when a mother's life is in danger (Brazil, Mexico, and Sudan). 18% of the world's population is covered by laws which permit an abortion only when a mother's life is in danger; this includes 19 countries in Africa, 11 in the Americas, nine in Asia, seven in the Middle East, and one in Europe (Ireland). PMID:12287145

  3. Abortion; 1 : 2 000 000

    The cartogram represents the crude rate of abortions (number of abortions per 1,000 inhabitants) in the individual districts, crude abortion rate in Slovakia: 0.54 %, number of all abortions (average of 1996 - 1998) is presented. The complicated mosaics reveals two main spatial cores of the highest abortion rate. The first is in the south-west of Slovakia, from Malacky to Komarno, and the second, the largest, is from Ziar nad Hronom and Velky Krtis as far as Michalovce. In contrary, the rate of abortions is registered in the northern districts of the eastern Slovakia, almost the whole region Presov and in the northern districts of the region of Zilina. The size of the sign expresses the absolute number of abortions and simultaneously the structure of abortions: spontaneous and induced abortions. The higher share of the spontaneous abortions (more than a quarter) generally occurs in the districts with the lowest abortion rate. (authors)

  4. A study on relationship be tween genital chlamydia trachomatis and ureaplasma urealyticum infection and spontaneous abortion%生殖道沙眼衣原体和解脲支原体感染与自然流产的相关性研究

    周萍

    2015-01-01

    目的:探讨生殖道沙眼衣原体和解脲支原体感染与自然流产的关系。方法选取我院自然流产患者(自然流产组)及人工流产患者(对照组),各60例。两组均采集宫颈分泌物及蜕膜组织进行沙眼衣原体和解脲支原体培养,分析结果。结果自然流产组宫颈分泌物及蜕膜组织中沙眼衣原体、解脲支原体、沙眼衣原体+解脲支原体感染率均高于对照组( P<0.01)。结论生殖道沙眼衣原体和解脲支原体感染率与自然流产关系密切,可作为确定自然流产病因的指标。%Objective To explore the corelation of genital chlamydia trachomatis and ureaplasma urealyticum infection with spontaneous abortion,and provide clinical reference for the prevention and control of spontaneous abortion .Methods Patients with spontaneous abortion were selected as spontaneous abortion group ( n =60) and artificial abortion group ( n =60), and cervical se-cretions and decidual tissue of chlamydia trachomatis and ureaplasma urealyticum were cultured and the results were analyzed .Results Infection rate of chlamydia trachomatis in cervical secretion of the natural abortion group ,ureaplasma urealyticum,chlamydia trachom-atis infection +UU rates of the natural abortion group were higher than that of the control group ( P <0.01).Conclusion Infection rate of genital chlamydia trachomatis and ureaplasma urealyticum infection rate and spontaneous abortion have a close relationship , which may be one of the causes of spontaneous abortion .

  5. Legalized Abortion in Japan

    Hart, Thomas M.

    1967-01-01

    The enactment of the Eugenic Protection Act in Japan was followed by many changes. The population explosion was stemmed, the birth rate was halved, and while the marriage rate remained steady the divorce rate declined. The annual total of abortions increased until 1955 and then slowly declined. The highest incidence of abortions in families is in the 30 to 34 age group when there are four children in the family. As elsewhere abortion in advanced stages of pregnancy is associated with high morbidity and mortality. There is little consensus as to the number of criminal abortions. Reasons for criminal abortions can be found in the legal restrictions concerning abortion: Licensing of the abortionist, certification of hospitals, taxation of operations and the requirement that abortion be reported. Other factors are price competition and the patient's desire for secrecy. Contraception is relatively ineffective as a birth control method in Japan. Oral contraceptives are not yet government approved. In 1958 alone 1.1 per cent of married women were sterilized and the incidence of sterilization was increasing. PMID:6062283

  6. Legalized abortion in Japan.

    Hart, T M

    1967-10-01

    The enactment of the Eugenic Protection Act in Japan was followed by many changes. The population explosion was stemmed, the birth rate was halved, and while the marriage rate remained steady the divorce rate declined. The annual total of abortions increased until 1955 and then slowly declined. The highest incidence of abortions in families is in the 30 to 34 age group when there are four children in the family. As elsewhere abortion in advanced stages of pregnancy is associated with high morbidity and mortality. There is little consensus as to the number of criminal abortions. Reasons for criminal abortions can be found in the legal restrictions concerning abortion: Licensing of the abortionist, certification of hospitals, taxation of operations and the requirement that abortion be reported. Other factors are price competition and the patient's desire for secrecy. Contraception is relatively ineffective as a birth control method in Japan. Oral contraceptives are not yet government approved. In 1958 alone 1.1 per cent of married women were sterilized and the incidence of sterilization was increasing. PMID:6062283

  7. Unintended Pregnancies, Restrictive Abortion Laws, and Abortion Demand

    Medoff, Marshall H.

    2012-01-01

    This study examines the effect restrictive state abortion laws have on the pregnancy resolution decisions of women with unintended pregnancies. The empirical results find that the abortion ratio and the abortion rate of unintended pregnancies are more sensitive to increases in the abortion price than previous estimates that analyzed total pregnancies (unintended and intended). A Medicaid funding restriction has very little effect on a state's abortion rate of unintended pregnancies, but cause...

  8. Abortion: the hidden plague.

    Tuckwell, S

    1974-05-01

    Abortion is called the invisible plague of all countries and cultures in the twentieth century. It is by far the most important method of birth control in the world today. For every 200 babies born there are at least 100 abortions. In the rich world, a woman who wants to end her pregnancy goes to an abortionist, but for millions of poor women, abortion happens spontaneously in their own homes induced by poor nutrition, sheer physical weakness, and too many pregnancies too close together. In countries where abortion is illegal, millions of women die each year as a result of severe illness or the botched handiwork of backyard operators. The most common complications are massive hemorrhaging, perforation of the uterus, laceration, sepsis, and renal failure. The experience of a great many countries shows that simply legalizing abortion can lead to a dramatic drop in death and illness. Relaxation of abortion laws can save lives, money, and misery for mothers and children. Illegal abortion has become a major problem in Africa there are 3 main types of women who enter hospitals with complications after abortions: 1) the teenager who is away from home; 2) the young woman, often educated, working, and with financial responsibilities, who is ambitious for herself, her husband, or her family; and 3) the woman in her thirties, illiterate, a rural worker, married most of her reproductive life, and pregnant most years. The third type of woman may abort because her system is utterly depleted. Such women must be shown that there is a good chance of survival for her children so that she will not have so many. PMID:12307249

  9. Effects of Abortion Legalization in Nepal, 2001–2010

    Henderson, Jillian T.; Puri, Mahesh; Blum, Maya; Harper, Cynthia C.; Rana, Ashma; Gurung, Geeta; Pradhan, Neelam; Regmi, Kiran; Malla, Kasturi; Sharma, Sudha; Grossman, Daniel; Bajracharya, Lata; Satyal, Indira; Acharya, Shridhar; Lamichhane, Prabhat; Darney, Philip D.

    2013-01-01

    Background Abortion was legalized in Nepal in 2002, following advocacy efforts highlighting high maternal mortality from unsafe abortion. We sought to assess whether legalization led to reductions in the most serious maternal health consequences of unsafe abortion. Methods We conducted retrospective medical chart review of all gynecological cases presenting at four large public referral hospitals in Nepal. For the years 2001–2010, all cases of spontaneous and induced abortion complications were identified, abstracted, and coded to classify cases of serious infection, injury, and systemic complications. We used segmented Poisson and ordinary logistic regression to test for trend and risks of serious complications for three time periods: before implementation (2001–2003), early implementation (2004–2006), and later implementation (2007–2010). Results 23,493 cases of abortion complications were identified. A significant downward trend in the proportion of serious infection, injury, and systemic complications was observed for the later implementation period, along with a decline in the risk of serious complications (OR 0.7, 95% CI 0.64, 0.85). Reductions in sepsis occurred sooner, during early implementation (OR 0.6, 95% CI 0.47, 0.75). Conclusion Over the study period, health care use and the population of reproductive aged women increased. Total fertility also declined by nearly half, despite relatively low contraceptive prevalence. Greater numbers of women likely obtained abortions and sought hospital care for complications following legalization, yet we observed a significant decline in the rate of serious abortion morbidity. The liberalization of abortion policy in Nepal has benefited women’s health, and likely contributes to falling maternal mortality in the country. The steepest decline was observed after expansion of the safe abortion program to include midlevel providers, second trimester training, and medication abortion, highlighting the importance

  10. Some research advances of immune mechanism during infection in China

    YANG Wei

    2011-01-01

    Newly emerging and reemerging infectious diseases continue to pose a substantial threat throughout the world.Understanding the immune mechanism during infection contributes not only to discoveries in science but also to advances in health care.Chinese researchers have made tremendous efforts to decipher the underlying mechanism of how pathogens elicit and evade immune responses and the immune homeostasis during infection.Here,we review new findings in Chinese studies concerning immune response to pathogens,immunoregulation and pathogen evasion,which offer us new insight into the trend in infectious immunology in China.

  11. Induced abortion in Indonesia.

    Hull, T H; Sarwono, S W; Widyantoro, N

    1993-01-01

    Induced abortion is one of the most difficult sociomedical problems facing the Indonesian government. While well-known in traditional society, the practice was discouraged by all Indonesian religious groups, and forbidden by the Dutch colonial authorities. Although abortion was technically illegal under the criminal code, a judicial interpretation in the early 1970s permitted medical professionals to offer the procedure so long as they were discreet and careful. The numbers of medical abortions carried out in Indonesia rose dramatically, and there was evidence of matching declines in the incidence of morbidity and mortality caused by dangerous illegal procedures. Medical and community groups campaigned for a more liberal abortion law to protect legal practitioners and stamp out illegal traditional practices. Their efforts appeared to bear fruit in the draft Health Law, but when the law was passed by the legislature in late 1992, the issue was again clouded by contradictions and inconsistencies. PMID:8212094

  12. [Interregional project concerning abortion].

    Jourdain, A; Pierotti, D; Vinclair, M

    1979-01-01

    The law legalizing abortion in France was passed in 1975. To group information of a social and medical nature and to publish reports on their activities, a questionnaire was designed to be filled by physicians and nurses working in centers and hospitals performing abortion. There were 19,000 abortions performed in 1976, and 30,000 are expected to be performed in 1979. The questionnaire contains 80 questions gathering information on socieconomic data, on medical history, on the procedure of the intervention, and on the follow-up visit. A study done on 5700 questionnaires filled between 1976 and 1977 show that most abortion seekers belong to the middle class, and that pregnancy was due in 20% of cases to pill failure, and in 34% of cases to failure of behavioral methods, or to lack of contraception. 88% of patients declared themselves satisfied with the procedure. PMID:12309432

  13. Autoimmune diseases and fungal infections: immunological mechanisms and therapeutic approaches

    ZHANG Jian-zhong

    2009-01-01

    @@ Autoimmune disease represents a breakdown of natural tolerance to autoreactive antigens.Pemphigus and lupus erythematosus are common autoimmune diseases either skin-specific or with predominant skin involvement. During the past decades,much progress has been made in understanding the mechanism of autoimmune diseases and the immunological mechanism in some infectious diseases such as fungal infections. Various novel approaches have been developed in the treatment of these diseases.

  14. Abortion in Present day Vietnam

    Nguyen Thanh Binh

    2012-01-01

    Full Text Available In recent years, the abortion rate in Vietnam has been likely rising. In rural area, this rate is a bit higher than in urban one. Young age groups’ abortion rate is relatively high and ofter higher than older age groups. The main reason is due to their limited awareness of contraceptive methods. Low education level also affects the abortion. The abortion of people at low education level is relatively high, but people with elementary school graduation has the lowest rate of abortion. The Northwest had the highest abortion rate, the lowest rate belonged to the South Central Coast. The abortion rate depends on each couple’s number of alive children. The highest abortion rate is of couples with 1 or 2 alive children. The majority of couples only have one time of abortion for 12 months before research timepoint.

  15. [Glimpses from the history of abortion].

    Holmdahl, B

    1992-05-01

    For a long time in human history, global population growth was checked by infant mortality, which ranged from 30-50% and did not start sinking until the beginning of the 1800s in the west. Child murder in the west was prohibited by law around the 1100-1200s, but it continued secretly. Among private people, induced abortion was allowed. In the holy scripts of Hinduism and Brahminism, abortion was prohibited. Hippocrates wrote that doctors should not give women abortifacient. The church father Augustinus stated that it was not within human power to discern when the soul entered the body, a circumstance that forbid abortion. A church meeting in 305 A.D. distanced itself from abortion, and this has been the stand of the Catholic Church ever since. In Sweden, exposing a child to the elements was practiced until the end of the 1200s, when it became prohibited. Protestants punished child murder by death. During 1759-78, 217 women were executed for child-killing. From the 1400s, church law punished abortion, and later, capital and punishment was meted out for it, but a distinction was made if the fetus was alive or stillborn. The law in 1734 punished abortion by the death of all concerned. The death penalty was abolished in 1864. In 1896, Anna Linholm reported to the policy in Uppsala that a midwife had been practicing clandestine abortions. Some of her patients were admitted to hospital for hemorrhaging. She was sentenced to hard labor. During 1851-1903, a total of 1408 abortions were reported to the health service. 90% of these became known because of death caused by obduction. Phosphorus was used for abortion in 1271 cases, arsenic in 62, and mechanical aids in 8 cases. About 1//2 of all female suicides at the end of the 1800s was performed by pregnant women who ate phosphorus. Almost all were unmarried, and 56% carried it out after the 5th month of pregnancy. In 1901, phosphorus was prohibited in Swedish homes. In 1875, free abortions became available. However, the

  16. Pathogenic mechanisms in the development of surgical site infections

    Jovanović Zorica

    2007-01-01

    Full Text Available Introduction. Surgical site infections represent a major problem in modern medicine. Bacterial survival and growth in surgical wounds depends on the effectiveness of the host defense mechanisms and on the ability of bacteria to resist these defensive mechanisms. Surgical site contamination causes cellular injury and triggers the inflammatory response. Host response to infection. An acute inflammatory response occurs within seconds to minutes of injury or invasion; it is non-specific and self-limiting. Mast cell degranulation, activation of three plasma systems and release of subcellular components from damaged cells occur as a consequence of cellular injury. Inflammation is mediated by a variety of soluble factors, including the complement system, the clotting system and the kinin system. The cell-derived mediators include histamine and serotonin, platelet activating factor, arachidonic acid metabolites (prostaglandins, leukotrienes, lipoxins, nitric oxide, and cytokines (regulators of host responses to infection, inflammation and immune responses. The main role of an inflammatory reaction is to recruit various cells and plasma components to the surgical site. Neutrophils are the first immune cells recruited at the site infection. Intracellular killing of microbes by neutrophils is accomplished through several mechanisms, including lysosomal enzymes and oxygen-dependent mechanisms. Later, local and blood-borne macrophages also migrate to the surgical site, initiate phagocytosis, and present antigens to T-lymphocytes in a recognizable form. Sepsis is a common systemic complication of infection. Septic shock is associated with severe infection and release of inflammatory mediators into the systemic circulation. The lipopolysaccharide from gram-negative bacteria contributes significantly to the pathogenesis of septic shock. The most common clinical manifestations of sepsis include fever or hypothermia, tachycardia, tachypnea, altered blood pressure

  17. The Response of Abortion Demand to Changes in Abortion Costs

    Medoff, Marshall H.

    2008-01-01

    This study uses pooled cross-section time-series data, over the years 1982, 1992 and 2000, to estimate the impact of various restrictive abortion laws on the demand for abortion. This study complements and extends prior research by explicitly including the price of obtaining an abortion in the estimation. The empirical results show that the real…

  18. Abortion: sin or crime?

    Kulpys, Žydrūnas

    2005-01-01

    Abortą nagrinėja ir moralinė teologija, ir kanonų teisė. Moralinė teologija gvildeną abortą kaip didelį moralinį blogį ir sunkią nuodėmę. Kanonų teisė nagrinėja abortą ir kaip teisinį nusikaltimą, už kurį automatiškai skiriama griežta sankcija - ekskomunikavimas. Kokiomis aplinkybėmis abortas yra nuodėmė ir kada jis tampa ir teisiniu nusikaltimu, automatiškai užtraukiančiu atskyrimą nuo Bažnyčios - ekskomunikavimą? Vien tik aborto nuodėmė neužtraukia ekskomunikos. Nors abortas yra sunki nuodė...

  19. Unsafe abortion in rural Tanzania

    Rasch, Vibeke; Sørensen, Pernille H; Wang, Anna R;

    2014-01-01

    BackgroundThe circumstances under which women obtain unsafe abortion vary and depend on the traditional methods known and the type of providers present. In rural Tanzania women often resort to traditional providers who use plant species as abortion remedies. Little is known about how these plants...... are used and their potential effect.MethodsData were obtained among women admitted with incomplete abortion at Kagera Regional Hospital during the period January - June, 2006. The women underwent an empathetic interview to determine if they had experienced an unsafe abortion prior to their admission....... In all 125/187 women revealed having had an unsafe abortion. The women identified as having had an unsafe abortion underwent a questionnaire interview where information about abortion provider and abortion method used was obtained through open-ended questions. To get more detailed information about...

  20. [Spontaneous abortion. Etiologic survey. Results].

    Baaklini, N; Anguenot, J L; Boulanger, J C; Vitse, M

    1990-12-01

    The definition of repeated spontaneous abortions is subject to caution. For some, it corresponds to at least three repeated spontaneous abortions with no normal previous pregnancy; for others, it comprises the repeated spontaneous abortions occurring after a normal pregnancy. It is a frequent problem, especially if one tries to give a wider definition. The authors studied the frequency of repeated spontaneous abortions in a continuous series of 14,857 pregnancies which took place between January 1982 and December 1988. In the study of the aetiology of the repeated spontaneous abortions in the various groups of women defined according to the number of previous pregnancies and abortions, they find the classical causes of repeated spontaneous abortions in all the categories: therefore, it seems legitimate to them that a wider definition be given for repeated spontaneous abortions. PMID:2291048

  1. HIV virology and pathogenetic mechanisms of infection: a brief overview

    Emanuele Fanales-Belasio

    2010-03-01

    Full Text Available Studies on HIV virology and pathogenesis address the complex mechanisms that result in the HIV infection of the cell and destruction of the immune system. These studies are focused on both the structure and the replication characteristics of HIV and on the interaction of the virus with the host. Continuous updating of knowledge on structure, variability and replication of HIV, as well as the characteristics of the host immune response, are essential to refine virological and immunological mechanisms associated with the viral infection and allow us to identify key molecules in the virus life cycle that can be important for the design of new diagnostic assays and specific antiviral drugs and vaccines. In this article we review the characteristics of molecular structure, replication and pathogenesis of HIV, with a particular focus on those aspects that are important for the design of diagnostic assays.

  2. Did Legalized Abortion Lower Crime?

    2001-01-01

    This paper examines the relationship between the legalization of abortion and subsequent decreases in crime. In a current study, researchers estimate that the legalization of abortion explains over half of the recent decline in national crime rates. The association is identified by correlating changes in crime with changes in the abortion ratio weighted by the proportion of the criminal population exposed to legalized abortion. In this paper, I use an alternative identification strategy. I an...

  3. A Shiite perspective toward abortion

    Kiarash Aramesh

    2006-01-01

    All schools of Islamic jurisprudence regard abortion as wrong and forbidden and allow abortion only before the stage of ensoulment, if the continuation of pregnancy would endanger the mother's life or put her into intolerable difficulties. In this article we describe and assess the viewpoint of Shiite jurisprudence toward abortion. "nUsing a selected collection of related references, and discussion describes with experts, this article the abortion in Shiite jurisprudence."nIn t...

  4. Tickborne fever associated with abortion outbreak in dairy cows.

    2016-08-20

    Anaplasma phagocytophilum detected in aborting cows on rough grazingLead poisoning in bullocksPersistent bovine viral diarrhoea virus infection and colisepticaemia in a 20-hour-old calfAbortion due to bovine herpesvirus 1 in a four-year-old cowTickborne fever in lambsInfectious sinusitis due to Mycoplasma gallisepticum in pheasants These are among matters discussed in the disease surveillance report for May 2016 from SAC Consulting: Veterinary Services (SAC C VS). PMID:27550334

  5. CMA abortion survey.

    1983-01-01

    Responses to the question as to whether abortions should be performed at the woman's request during the first trimester of pregnancy were evenly divided. There was support for abortion on socioeconomic grounds, during the first trimester, from 61.5% of the respondents. Termination of pregnancy beyond the first trimester was supported by a majority of the respondents only in cases in which the woman's life is in danger (73.9%) or in which there is evidence of a severe physical abnormality in t...

  6. Did Legalized Abortion Lower Crime?

    Joyce, Ted

    2004-01-01

    Changes in homicide and arrest rates were compared among cohorts born before and after legalization of abortion and those who were unexposed to legalized abortion. It was found that legalized abortion improved the lives of many women as they could avoid unwanted births.

  7. College Students' Attitudes Toward Abortion

    Maxwell, Joseph W.

    1970-01-01

    Attitudes toward the desirability of abortion were significaantly related to sex, college, classification, level of church activity, residence background, family size, exposure to abortion, and attitude toward premarital sex. The data suggest an increasing acceptance of abortion in the future. (Author)

  8. Pregnancy outcome following spontaneous abortions

    Swati Agrawal

    2015-12-01

    Conclusions: Previous history of spontaneous abortion is associated with adverse pregnancy outcome. There is increased risk of abortion, preterm delivery, need for caesarean sections and fetal loss in cases of previous spontaneous abortions. These complications and fetal loss can be reduced by booking the patients and giving due antenatal care. [Int J Reprod Contracept Obstet Gynecol 2015; 4(6.000: 1891-1893

  9. Abortion: Strong's counterexamples fail

    Di Nucci, Ezio

    2009-01-01

    This paper shows that the counterexamples proposed by Strong in 2008 in the Journal of Medical Ethics to Marquis's argument against abortion fail. Strong's basic idea is that there are cases--for example, terminally ill patients--where killing an adult human being is prima facie seriously morally...

  10. Abortion health services in Canada

    Norman, Wendy V.; Guilbert, Edith R.; Okpaleke, Christopher; Hayden, Althea S.; Steven Lichtenberg, E.; Paul, Maureen; White, Katharine O’Connell; Jones, Heidi E.

    2016-01-01

    Abstract Objective To determine the location of Canadian abortion services relative to where reproductive-age women reside, and the characteristics of abortion facilities and providers. Design An international survey was adapted for Canadian relevance. Public sources and professional networks were used to identify facilities. The bilingual survey was distributed by mail and e-mail from July to November 2013. Setting Canada. Participants A total of 94 abortion facilities were identified. Main outcome measures The number and location of services were compared with the distribution of reproductive-age women by location of residence. Results We identified 94 Canadian facilities providing abortion in 2012, with 48.9% in Quebec. The response rate was 83.0% (78 of 94). Facilities in every jurisdiction with services responded. In Quebec and British Columbia abortion services are nearly equally present in large urban centres and rural locations throughout the provinces; in other Canadian provinces services are chiefly located in large urban areas. No abortion services were identified in Prince Edward Island. Respondents reported provision of 75 650 abortions in 2012 (including 4.0% by medical abortion). Canadian facilities reported minimal or no harassment, in stark contrast to American facilities that responded to the same survey. Conclusion Access to abortion services varies by region across Canada. Services are not equitably distributed in relation to the regions where reproductive-age women reside. British Columbia and Quebec have demonstrated effective strategies to address disparities. Health policy and service improvements have the potential to address current abortion access inequity in Canada. These measures include improved access to mifepristone for medical abortion; provincial policies to support abortion services; routine abortion training within family medicine residency programs; and increasing the scope of practice for nurses and midwives to include abortion

  11. Radical surgery in septic abortion.

    Chatterjee, P; Ghosh, M; Ghosh, S

    1979-08-01

    At R.G. Kar Medical College Hospital, Calcutta, 10 cases of septic abortion from 1975-1977 were studied. Hysterectomies were preformed on 4 cases due to emergency situations including traumatised uterine fundus and perforated cervix, and on 6 cases after conservative treatment. Upon performing laparotomy in 9 cases, a uterine rent was detected; in 1 case there was a perforation in the posterior wall of the cervix, and in 5 cases mechanical obstructions due to internal adhesions to the uterine rent were found. 4 patients died primarily because of the patients seeking help too late. It is suggested that under high risk circumstances, laparotomy is advantageous to conservative medical management since bowel injuries and mechanical obstructions can only be detected by laparotomy. Radical surgery, however, should be undertaken before the patients general condition deteriorates to the point that the patient cannot tolerate surgical intervention. PMID:12336028

  12. Mechanism of intrauterine infection of hepatitis B virus

    Shu-Lin Zhang; Ya-Fei Yue; Gui-Qin Bai; Lei Shi; Hui Jiang

    2004-01-01

    AIM: To explore the possible mechanism of intrauterine infection of hepatitis B virus (HBV).METHODS: HBV DNA was detected in vaginal secretion and amniotic fluid from 59 HBsAg-positive mothers and in venous blood of their newborns by PCR. HBsAg and HBcAg in placenta were determined by ABC immunohistochemistry.RESULTS: The rate of HBV intrauterine infection was 40.l% (24/59). HBV DNA was detected in 47.5% of amniotic fluid samples and 52.5% of vaginal secretion samples respectively.HBsAg and HBcAg were detected in placentas from HBsAgpositive mothers. The concentration of the two antigens decreased from the mother's side to the fetus's side, in the following order: maternal decidual cells > trophoblastic cells > villous mesenchymal cells > villous capillary endothelial cells. However, in 4 placentas the distribution was in the reverse order. HBsAg and HBcAg were detected in amniotic epithelial cells from 32 mothers.CONCLUSION: The main route of HBV transmission from mother to fetus is transplacental, from the mother side of placenta to the fetus side. However, HBV intrauterine infection may take place through other routes.

  13. The consequences of abortion legislation.

    Braude, M

    1983-01-01

    This article examines the consequences of the 1973 US Supreme Court decision legalizing abortion as well as potential implications of proposed legilation aimed at nullifying this decision. In addition to giving women the right to determine their own reproduction, legal abortion had had beneficial health effects for both mothers and infants. The partial reversal of abortion gains due to restrictions on public funding and limitations on how and where abortions can be performed has produced a slight increase in abortion mortality, but the impact has not been dramatic. Moreover, each year since 1973, women have been obtaining abortions earlier in pregnancy. Abortion may be experienced as a loss by the mother, but there is no evidence of serious psychological sequelae. In contrast, a large body of evidence supports the physical, psychological, and social benefits of legal abortion to women, children, and families. However, proponents of the proposed Human Life Amendment place protection of the rights of the fetus over all other considerations. Their antiabortion actions have challenged the medical tradition of privacy and the confidentiality of the doctor-patient relationship. Most supporters of legal abortion would prefer that there be fewer abortions; such a decrease is more likely as a result of better education and contraceptive methods rather than coercion. PMID:12340335

  14. Abortion: taking the debate seriously.

    Kottow Lang, Miguel Hugo

    2015-01-01

    Voluntarily induced abortion has been under permanent dispute and legal regulations, because societies invariably condemn extramarital pregnancies. In recent decades, a measure of societal tolerance has led to decriminalize and legalize abortion in accordance with one of two models: a more restricted and conservative model known as therapeutic abortion, and the model that accepts voluntary abortion within the first trimester of pregnancy. Liberalization of abortion aims at ending clandestine abortions and decriminalizes the practice in order to increase reproductive education and accessibility of contraceptive methods, dissuade women from interrupting their pregnancy and, ultimately, make abortion a medically safe procedure within the boundaries of the law, inspired by efforts to reduce the incidence of this practice. The current legal initiative to decriminalize abortion in Chile proposes a notably rigid set of indications which would not resolve the three main objectives that need to be considered: 1) Establish the legal framework of abortion; 2) Contribute to reduce social unrest; 3) Solve the public health issue of clandestine, illegal abortions. Debate must urgently be opened to include alternatives in line with the general tendency to respect women's decision within the first trimester of pregnancy. PMID:26057783

  15. Austerity and Abortion in the European Union.

    Lima, Joana Madureira; Reeves, Aaron; Billari, Francesco; McKee, Martin; Stuckler, David

    2016-06-01

    Economic hardship accompanying large recessions can lead families to terminate unplanned pregnancies. To assess whether abortions have risen during the recession, we collected crude abortion data from 2000 to 2012 from Eurostat for countries that had legal abortions and complete data. Declining trends in abortion ratios between 2000 and 2009 have been reversing. Excess abortions between 2010 and 2012 totaled 10.6 abortions per 1000 pregnancies ending in abortion or birth or 6701 additional abortions (95% CI 1190-9240) with stronger effects in younger ages. Economic shocks may increase recourse to abortion. Further research should explore causal pathways and protective factors. PMID:27009038

  16. Abortion Performance and Politics

    Candelario, Rosemary

    2012-01-01

    “Performing abortion” typically refers to what health care providers do in clinics, private offices, and (rarely) hospitals 1.21 million times per year,every year, in the United States. At the same time, the phrase indicates what performance artists, choreographers, and activists have been doing on stages, in galleries, and on the streets for decades. Candelario is intrigued by this double meaning that invites us to take seriously what abortion means at this political and historical moment, b...

  17. Abortion, Law and Ideology

    Claudia Escobar García

    2012-12-01

    Full Text Available This work explains that the discourses opposing the criminalization ofabortion and that reject the constitutional rules that protect human life,are an artificially constructed ideology made only to justify abortion,and hide the asymmetrical relations of power between women and theunborn. In order for this purpose, these arguments are identified andsubjected to critical analysis, demonstrating that it is purely emotionaland lacking fundaments.

  18. Modifications of lung clearance mechanisms by acute influenza A infection

    Four volunteers with naturally acquired, culture-proved influenza A infection inhaled a radiolabeled aerosol to permit investigation of lung mucociliary clearance mechanisms during and after symptomatic illness. Mucus transport in the trachea was undetectable when monitored with an external multidetector probe within 48 hours of the onset of the illness, but was found at a normal velocity by 1 week in three of the four subjects. In two volunteers who coughed 23 to 48 times during the 4.5-hour observation period, whole lung clearance was as fast within the first 48 hours of illness as during health 3 months later in spite of the absence of measurable tracheal mucus transport. Conversely, in spite of the return 1 week later of mucus transport at velocities expected in the trachea, whole lung clearance for the 4.5-hour period was slowed in two volunteers who coughed less than once an hour. The data offer evidence that cough is important in maintaining lung clearance for at least several days after symptomatic influenza A infection when other mechanisms that depend on ciliary function are severely deficient

  19. Abortion law reform in Nepal.

    Upreti, Melissa

    2014-08-01

    Across four decades of political and social action, Nepal changed from a country strongly enforcing oppressive abortion restrictions, causing many poor women's long imprisonment and high rates of abortion-related maternal mortality, into a modern democracy with a liberal abortion law. The medical and public health communities supported women's rights activists in invoking legal principles of equality and non-discrimination as a basis for change. Legislative reform of the criminal ban in 2002 and the adoption of an Interim Constitution recognizing women's reproductive rights as fundamental rights in 2007 inspired the Supreme Court in 2009 to rule that denial of women's access to abortion services because of poverty violated their constitutional rights. The government must now provide services under criteria for access without charge, and services must be decentralized to promote equitable access. A strong legal foundation now exists for progress in social justice to broaden abortion access and reduce abortion stigma. PMID:24890742

  20. Legal abortion and public health.

    Tietze, C

    1984-01-01

    Over 15 million abortions have been performed in the US since the process of abortion legalization began in 1967. Consequences of legalization have included a marked reduction of pregnancy-related mortality and the prevention in many cases of the birth of infants with major physical or mental defects. Prenatal diagnosis, backed up by selective abortion, has made procreation a possibility for many couples who might otherwise avoid childbearing. However, the number of abortions performed on the basis of prenatal diagnosis remains small, comprising only about .01% of all legal abortions. In recent months, the pro-choice movement in the US has been handed 2 important victories: the US Supreme Court reaffirmed the 1973 decision legalizing abortion and the US Senate defeated a constitutional amendment intended to reverse this decision. As a result of these victories, contributions to pro-choice groups have declined. Continued vigilance is needed to protect these victories. PMID:12267089

  1. Dworkin and Casey on abortion.

    Stroud, Sarah

    1996-01-01

    This article responds to two important recent treatments of abortion rights. I will mainly discuss Ronald Dworkin's recent writings concerning abortion: his article "Unenumerated rights: whether and how Roe should be overruled," and his book Life's Dominion. In these writings Dworkin presents a novel view of what the constitutional and moral argument surronding abortion is really about. Both debates actually turn, he argues, on the question of how to interpret the widely shared idea that human life is sacred. At the heart of the abortion debate is the essentially religious notion that human life has value which transcends its value to any particular person; abortion is therefore at bottom a religious issue. Dworkin hopes to use this analysis to show that the religion clauses of the First Amendment provide a "textual home" for a woman's right to choose abortion. I wish to scrutinize this suggestion here; I want to probe the precise consequences for abortion rights of such an understanding of their basis. I will argue that the consequences are more radical than Dworkin seems to realize. The other work I will examine here is the important 1992 Supreme Court decision on abortion, Planned Parenthood v. Casey. The controlling opinion in that case, written jointly by Justices Kennedy, O'Connor, and Souter, strongly reaffirmed Roe v. Wade, but also upheld most of the provisions of a Pennsylvania statute that had mandated various restrictions on abortion. The justices' basis for upholding these restictions was their introduction of a new constitutional standard for abortion regulations, an apparently weaker standard than those that had governed previous Supreme Court abortion decisions. I think there is a flaw in Casey's new constitutional test for abortion regulations, and I will explain, when we turn to Casey, what it is and why it bears a close relation to Dworkin's reluctance to carry his argument as far as it seems to go. PMID:11660187

  2. Psychiatric aspects of therapeutic abortion *

    Doane, Benjamin K.; Quigley, Beverly G.

    1981-01-01

    A search of the literature on the psychiatric aspects of abortion revealed poor study design, a lack of clear criteria for decisions for or against abortion, poor definition of psychologic symptoms experienced by patients, absence of control groups in clinical studies, and indecisiveness and uncritical attitudes in writers from various disciplines. A review of the sequelae of therapeutic abortion revealed that although the data are vague, symptoms of depression were reported most frequently, ...

  3. Chlamydia pecorum: fetal and placental lesions in sporadic caprine abortion.

    Giannitti, Federico; Anderson, Mark; Miller, Myrna; Rowe, Joan; Sverlow, Karen; Vasquez, Marce; Cantón, Germán

    2016-03-01

    Chlamydial abortion in small ruminants is usually associated with Chlamydia abortus infection. Although Chlamydia pecorum has been detected in aborted ruminants and epidemiological data suggests that C. pecorum is abortigenic in these species, published descriptions of lesions in fetuses are lacking. This work describes fetoplacental lesions in a caprine abortion with C. pecorum infection, and further supports the abortigenic role of C. pecorum in ruminants. A 16-month-old Boer goat aborted twin fetuses at ~130 days of gestation. Both fetuses (A and B) and the placenta of fetus A were submitted for postmortem examination and diagnostic workup. At autopsy, the fetuses had moderate anasarca, intermuscular edema in the hindquarters (A), and brachygnathia and palatoschisis (B). In the placenta, the cotyledons were covered by yellow fibrinosuppurative exudate that extended into the adjacent intercotyledonary areas. Histologically, there was severe suppurative and necrotizing placentitis with vasculitis (arteriolitis) and thrombosis, multifocal lymphohistiocytic and neutrophilic hepatitis (A), and fibrinosuppurative enteritis in both fetuses. Chlamydia antigen was detected in the placenta by the direct fluorescent antibody test and in fetal intestines by immunohistochemistry. Nested polymerase chain reaction of DNA extracted from formalin-fixed, paraffin-embedded sections of placenta and intestine amplified 400 bp of the Chlamydia 16S rRNA gene that was sequenced and found to be 99% identical to C. pecorum by BLAST analysis. Other known abortigenic infectious agents were ruled out by specific testing. It is concluded that C. pecorum infection is associated with fetoplacental lesions and sporadic abortion in goats. PMID:26965241

  4. A Shiite perspective toward abortion

    Kiarash Aramesh

    2006-03-01

    Full Text Available All schools of Islamic jurisprudence regard abortion as wrong and forbidden and allow abortion only before the stage of ensoulment, if the continuation of pregnancy would endanger the mother's life or put her into intolerable difficulties. In this article we describe and assess the viewpoint of Shiite jurisprudence toward abortion. "nUsing a selected collection of related references, and discussion describes with experts, this article the abortion in Shiite jurisprudence."nIn the Shiite jurisprudence, the ensoulment occurs after about 4 months. Before this stage, all Shiite authorities regard abortion as forbidden (Hiram unless if continuing the pregnancy would put the mother's life in real danger or will be intolerable for her. But after that, they regard abortion as Hiram, unless in conditions in which continuing the pregnancy results in dying of both mother and fetus, but abortion will save the life of mother. However, the Shiite authorities have not accepted to legitimate abortion in unwanted pregnancies and even in pregnancies resulted from adultery (Zina or rape."nThe debate over abortion is still controversial as ever. There are some important and notable related Fatwas that make jurisprudical basis for some new and problem solving legal acts, showing the inherent and valuable flexibility of the Shiite jurisprudence in dealing with such important issues. Some related issues, such as the priority of saving the life of mother after ensoulment can be referred to jurisprudical authorities for more assessment.

  5. Abortion, Miscarriage, and Breast Cancer Risk

    ... of Breast & Gynecologic Cancers Breast Cancer Screening Research Abortion, Miscarriage, and Breast Cancer Risk A woman’s hormone ... be conducted to determine whether having an induced abortion, or a miscarriage (also known as spontaneous abortion), ...

  6. The Impact of Legalized Abortion on Crime

    Donohue, John J, III; Steven D. Levitt

    2000-01-01

    We offer evidence that legalized abortion has contributed significantly to recent crime reductions. Crime began to fall roughly 18 years after abortion legalization. The 5 states that allowed abortion in 1970 experienced declines earlier than the rest of the nation, which legalized in 1973 with Roe v. Wade. States with high abortion rates in the 1970s and 1980s experienced greater crime reductions in the 1990s. In high abortion states, only arrests of those born after abortion legaliz...

  7. The Impact of Legalized Abortion on Crime

    Donohue, John J.; Levitt, Steven D.

    2000-01-01

    We offer evidence that legalized abortion has contributed significantly to recent crime reductions. Crime began to fall roughly 18 years after abortion legalization. The 5 states that allowed abortion in 1970 experienced declines earlier than the rest of the nation, which legalized in 1973 with Roe v. Wade. States with high abortion rates in the 1970s and 1980s experienced greater crime reductions in the 1990s. In high abortion states, only arrests of those born after abortion legalization fa...

  8. Abortion - a philosophical perspective

    MN Jali

    2001-01-01

    The central issue in the abortion debate is the moral status of the conceptus. There are two positions that argue this issue. At one extreme are the views of the pro-life group which argues that human life begins at the moment of conception whilst at the other are views of the pro-choice group that argues in favour of a woman’s right to self-determination. Two basic principles come into conflict in this debate, namely the Value of Life and that of Self-determination. In this paper the argumen...

  9. Heat shock cognate protein 70 contributes to Brucella invasion into trophoblast giant cells that cause infectious abortion

    Furuoka Hidefumi

    2008-12-01

    Full Text Available Abstract Background The cell tropism of Brucella abortus, a causative agent of brucellosis and facultative intracellular pathogen, in the placenta is thought to be a key event of infectious abortion, although the molecular mechanism for this is largely unknown. There is a higher degree of bacterial colonization in the placenta than in other organs and many bacteria are detected in trophoblast giant (TG cells in the placenta. In the present study, we investigated mechanism of B. abortus invasion into TG cells. Results We observed internalization and intracellular growth of B. abortus in cultured TG cells. A monoclonal antibody that inhibits bacterial internalization was isolated and this reacted with heat shock cognate protein 70 (Hsc70. Depletion and over expression of Hsc70 in TG cells inhibited and promoted bacterial internalization, respectively. IFN-γ receptor was expressed in TG cells and IFN-γ treatment enhanced the uptake of bacteria by TG cells. Administering the anti-Hsc70 antibody to pregnant mice served to prevent infectious abortion. Conclusion B. abortus infection of TG cells in placenta is mediated by Hsc70, and that such infection leads to infectious abortion.

  10. Sociocultural determinants of induced abortion

    Objective: To determine the frequency of induced abortion and identity the role of sociocultural factors contributing to termination of pregnancy and associated morbidity and mortality in hospital setting. Subjects and Methods: The patients who were admitted for induced abortion were interviewed in privacy. On condition of anonymity they were asked about the age, parity, family setup and relationships, with particular emphasis on sociocultural reasons and factors contributing to induction of abortion. Details of status of abortionist and methods used for termination of pregnancy, the resulting complications and their severity were recorded. Results: Out of total admissions, 57(2.35%) gave history of induced abortion. All women belonged to low socioeconomic class and 59.6% of them were illiterate. Forty-three (75.5%) of these women had never practiced concentration. Twenty-four (42%) were grandmultiparae and did not want more children. In 29 women (50.9%) the decision for abortion had been supported by the husband. In 25 (43.8%) abortion was carried out by Daiyan (traditional midwives). Serious complications like uterine perforation with or without bowel injury were encouraged in 25 (43.8%) of these women. During the study period illegally induced abortion accounted for 6 (10.5%) maternal deaths. Conclusion: Prevalence of poverty, illiteracy, grand multiparity and non-practice of contraception are strong determinants of induced abortion. (author)

  11. Advice in the Abortion Decision

    Luscutoff, Sidney A.; Elms, Alan C.

    1975-01-01

    Subjects in this study were asked to report the number of contacts-for-advice they had made when forming decisions to have a therapeutic abortion, or to carry a pregnancy to term. As predicted, the abortion group differed strongly from both other groups on most questions. (Author)

  12. Birth, meaningful viability and abortion.

    Jensen, David

    2015-06-01

    What role does birth play in the debate about elective abortion? Does the wrongness of infanticide imply the wrongness of late-term abortion? In this paper, I argue that the same or similar factors that make birth morally significant with regard to abortion make meaningful viability morally significant due to the relatively arbitrary time of birth. I do this by considering the positions of Mary Anne Warren and José Luis Bermúdez who argue that birth is significant enough that the wrongness of infanticide does not imply the wrongness of late-term abortion. On the basis of the relatively arbitrary timing of birth, I argue that meaningful viability is the point at which elective abortion is prima facie morally wrong. PMID:25012846

  13. Teenage pregnancies and abortion.

    Morgenthau, J E

    1984-01-01

    The issue of abortion, except when it is rendered moot because the fetus endangers the life of the mother, is not really a medical issue. The physician's role is to help patients achieve and maintain their maximum potential for physical, mental, and social well-being. To accomplish this, the physician must acquire a constantly evolving database of scientific knowledge, must evaluate this information in a critical and ethical manner, and must be prepared to apply what is learned. In the realm of applied ethics, no particular religion, profession, culture, class, or sex should be thought of as having all the answers in the realm of applied ethics. This physician's actions are predicated on the belief that, to a large extent, ethical precepts reflect the broader social and economic issues of the period in which they are articulated. If this is the case, then in today's world the population explosion, the postindustrial society, the women's rights movement, inequality of access, and the ability to perform prenatal diagnosis are all factors which have molded the approach to the issue of abortion. Only the last 3 of these can in any way be considered as medical. When considering the role of a physician in dealing with the issue of abortion in the adolescent, this individual relies on the concept articulated by the World Health Association (WHA): promoting the physical, emotional, and social well-being of one's patients. Each year in the US over 1 million 15-19 year olds become pregnant, resulting in over 600,000 births. Most of these pregnancies are unintentional, yet approximately 90% of the infants are kept in the home by mothers who are ill prepared to be parents. What is most disturbing is that the pregnancy rate for the younger mother, 16 years or under, is accounting for an ever increasing percentage of the total. Studies at the Adolescent Health Center of the Mount Sinai Hospital in New York City as well as national studies suggest that the younger teens are more

  14. New aspects of the infection mechanisms of Bacillus anthracis.

    Zakowska, Dorota; Bartoszcze, Michał; Niemcewicz, Marcin; Bielawska-Drózd, Agata; Kocik, Janusz

    2012-01-01

    Articles concerning new aspects of B. anthracis mechanisms of infection were reviewed. It was found, that the hair follicle plays an important role in the spore germination process. The hair follicle represent an important portal of entry in the course of the cutaneous form of disease infections. After mouse exposition to aerosol of spores prepared from B. anthracis strains, an increase in the level of TNF-α cytokines was observed. The TNF-α cytokines were produced after intrusion into the host by the microorganism. This process may play a significant role in the induced migration of infected cells APCs (Antigen Presenting Cells) via chemotactic signals to the lymph nodes. It was explained that IgG, which binds to the spore surface, activates the adaptive immune system response. As a result, the release C3b opsonin from the spore surface, and mediating of C3 protein fragments of B. anthracis spores phagocytosis by human macrophages, was observed. The genes coding germination spores protein in mutant strains of B. anthracis MIGD was a crucial discovery. According to this, it could be assumed that the activity of B. anthracis spores germination process is dependent upon the sleB, cwlJ1 and cwlJ2 genes, which code the GSLEs lithic enzymes. It was also discovered that the specific antibody for PA20, which binds to the PA20 antigenic determinant, are able to block further PA83 proteolytic fission on the surface of cells. This process neutralized PA functions and weakened the activity of free PA20, which is produced during the PA83 enzyme fission process. Interaction between PA63 monomer and LF may be helpful in the PA63 oligomerization and grouping process, and the creation of LF/PA63 complexes may be a part of an alternative process of assembling the anthrax toxin on the surface of cells. It was found that actin-dependent endocytosis plays an important role in the PA heptamerisation process and leads to blocking the toxin activity. Chaperones, a protein derived from

  15. Abortive infection of Lutzomyia longipalpis insect vectors by aflagellated LdARL-3A-Q70L overexpressing Leishmania amazonensis parasites.

    Cuvillier, Armelle; Miranda, Jose Carlos; Ambit, Audrey; Barral, Aldina; Merlin, Gilles

    2003-10-01

    Leishmania donovani ADP-ribosylation factor-like protein 3A (LdARL-3A) is a small G protein isolated from the protozoan parasite L. donovani with no defined physiological function. Previously [Cuvillier, A., Redon, F., Antoine, J.-C., Chardin, P., DeVos, T., and Merlin, G. (2000) J Cell Sci 113: 2065-2074] we have shown that overexpression in L. amazonensis promastigotes of the mutated protein LdARL-3A-Q70L, which remains constitutively associated with GTP, leads to the disappearance of the flagellum but does not impair cell viability or growth. Here we report that parasites overexpressing LdARL-3A-Q70L can invade in vitro cultivated macrophages to the same extent as control cells, demonstrating that the flagellum is not necessary for attachment to or engulfment into macrophages. These infections are productive because amastigotes differentiate and multiply. However, aflagellated LdARL-3A-Q70L-overexpressing Leishmania promastigotes could not survive in experimentally infected Lutzomyia longipalpis insect vectors, in contrast to untransfected or native LdARL-3A-overexpressing cells. Overexpression of the native and mutated proteins did not modify in vitro procyclic to metacyclic lipophosphoglycan maturation or differentiation from procyclic to metacyclic promastigotes, nevertheless there is a block in transmission of Leishmania. Better understanding of LdARL-3A pathways, notably those regarding flagellum biogenesis, may lead to the future development of Leishmania-specific drugs, which may stop parasite transmission in nature without affecting other species. PMID:12969377

  16. Study of karyotypes in Case of Recurrent Abortions in Gujarat

    N. Parikh; Rawal, J; Oza, S; B. M. Patel; H. R. Jadav; C A Pensi

    2015-01-01

    Introduction: - The biological definition of miscarriage is the expulsion of the conceptus before viability has been achieved. The definition of recurrent miscarriage is three or more consecutive spontaneous abortions. The risk factors for recurrent miscarriage are epidemiological, genetic, anatomical disorders, endocrinal, reproductive tract infections, thrombophilic disorders, disorders of materno-fetal alloimmune relationships, environmental effects and psychological causes. About 50% to 6...

  17. Outbreak of Salmonella Dublin-associated abortion in Danish fur farms

    Dietz, Hans Henrich; Chriél, Mariann; Andersen, Thomas Holmen; Jorgensen, Jens Christian; Torpdahl, Mia; Pedersen, Hans; Pedersen, Karl

    2006-01-01

    Outbreaks of Salmonella Dublin infections were recorded in 25 Danish mink and fox farms. All farms suffered extensive disease problems; clinical and pathological observations included abortion, stillbirths, necrotizing endometritis, and increased mortality. By genotyping with pulsed-field gel...

  18. 28 CFR 551.23 - Abortion.

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Abortion. 551.23 Section 551.23 Judicial..., Pregnancy, Child Placement, and Abortion § 551.23 Abortion. (a) The inmate has the responsibility to decide either to have an abortion or to bear the child. (b) The Warden shall offer to provide each...

  19. New German abortion law agreed.

    Karcher, H L

    1995-07-15

    The German Bundestag has passed a compromise abortion law that makes an abortion performed within the first three months of pregnancy an unlawful but unpunishable act if the woman has sought independent counseling first. Article 218 of the German penal code, which was established in 1871 under Otto von Bismarck, had allowed abortions for certain medical or ethical reasons. After the end of the first world war, the Social Democrats tried to legalize all abortions performed in the first three months of pregnancy, but failed. In 1974, abortion on demand during the first 12 weeks was declared legal and unpunishable under the social liberal coalition government of chancellor Willy Brandt; however, the same year, the German Federal Constitution Court in Karlsruhe ruled the bill was incompatible with article 2 of the constitution, which guarantees the right to life and freedom from bodily harm to everyone, including the unborn. The highest German court also ruled that a pregnant woman had to seek a second opinion from an independent doctor before undergoing an abortion. A new, extended article 218, which included a clause giving social indications, was passed by the Bundestag. When Germany was unified, East Germans agreed to be governed by all West German laws, except article 218. The Bundestag was given 2 years to revise the article; however, in 1993, the Federal Constitution Court rejected a version legalizing abortion in the first 3 months of the pregnancy if the woman sought counsel from an independent physician, and suggested the recent compromise passed by the Bundestag, the lower house of the German parliament. The upper house, the Bundesrat, where the Social Democrats are in the majority, still has to pass it. Under the bill passed by the Bundestag, national health insurance will pay for an abortion if the monthly income of the woman seeking the abortion falls under a certain limit. PMID:7613423

  20. The Question of Abortion in Serbia

    Rasevic, Mirjana

    2009-01-01

    Induced abortion has for a long time been a predominant method of birth control in Serbia. With spreading of contraception, significance of induced abortion became to a decrease. Besides this positive trend, estimated number of induced abortions about 200000 abortions per a year shows that a significant number of women mostly, and a certain number of women exclusively, relies on this method of birth control.Research findings discovered a complex array of factors of abortion problem, including...

  1. Reproductive rights: Current issues of late abortion

    Mujović-Zornić Hajrija

    2009-01-01

    This article considers the legal issues surrounding induced late abortion in cases when severe medical, therapeutic or ethical reasons have not been in dispute. Generally discussing the essential question about abortion today, it means not anymore legality of abortion but, in the first place, safety of abortion. From the aspect of woman health the most important aim is to detect and avoid possible risks of medical intervention, such as late abortion present. This is the matter of medical law ...

  2. Aborting a malformed fetus: a debatable issue in saudi arabia.

    Al-Alaiyan, Saleh; Alfaleh, Khalid M

    2012-01-01

    Congenital anomalies contribute a significant proportion of infant morbidity and mortality, as well as fetal mortality. They are generally grouped into three major categories: structural/metabolic, congenital infections, and other conditions. The most prevalent conditions include congenital heart defects, orofacial clefts, Down syndrome, and neural tube defects. Several prenatal diagnostic procedures have been introduced, both cytogenetic (such as chorion biopsy, amniocentesis and funiculocentesis) and biophysical (ultrasound 2-D, 3-D and 4-D, ultrasonography with Doppler, etc.). Insufficient data are currently available from Saudi Arabia on the epidemiology of the lethal congenital abnormalities which should be a priority due to high rate of consanguineous marriages among first cousins and their association with congenital anomalies. In terms of consanguinity and birth defects, a significant positive association has been consistently demonstrated between consanguinity and morbidity, and congenital defects with a complex etiology appear to be both more prevalent in consanguineous families and have a greater likelihood of recurrence. A debate regarding aborting a malformed fetus still exists among the senior Islamic scholars in many of the Islamic countries. The progressive interpretations of Islam have resulted in laws allowing for early abortion on request in two countries; six others permit abortion on health grounds and three more also allow abortion in cases of rape or fetal impairment. In Saudi Arabia, efforts to legalize abortion in certain circumstances have been recently discussed among Senior Religious Scholars and specialized physicians to permit abortions in certain circumstances. In this mini-review we discuss the current debate regarding aborting a malformed fetus in Saudi Arabia with a focus on the Islamic perspective. PMID:24027674

  3. Nitric oxide levels in women with missed and threatened abortion: results of a pilot study.

    Paradisi, Roberto; Fabbri, Raffaella; Battaglia, Cesare; Facchinetti, Fabio; Venturoli, Stefano

    2007-09-01

    The aim of this study was to evaluate the systemic production of nitric oxide (NO) in missed and threatened abortion and in nonpregnant and regular pregnant controls with the purpose of defining its role in the mechanisms regulating the first-trimester pregnancy toward either positive or negative evolution. Patients with missed abortion showed serum NO levels clearly decreased compared with nonpregnant patients and patients with regular pregnancy and threatened abortion, supporting a direct functional role of the NO mediator in early embryonic development and confirming its importance in the uterus and cervix during abortion. PMID:17349639

  4. The Development of Instruments to Measure Attitudes toward Abortion and Knowledge of Abortion

    Snegroff, Stanley

    1976-01-01

    This study developed an abortion attitude scale and abortion knowledge inventory that may be utilized by health educators, counselors, and researchers for assessing attitudes toward abortion and knowledge about it. (SK)

  5. Participation of nurses in abortions.

    Neustatter, P L

    1980-11-29

    Doctors for a Woman's Choice on Abortion would agree with 1 point in Lord Denning's ruling on the role of nurses in abortions induced by (PGS) prostaglandins (November 15, p. 1091). The nurse should not be doing a doctor's job, as Lord Denning indicated, and we sympathize with any nurse who is doing so (though the 1967 Abortion Act allows any nurse to abstain, on grounds of conscience). However, the ruling that nurses are not legally covered to participate in any way with the "procuring of a miscarriage" (using terminology of the 1861 Offenses against the Persons Act upon which the ruling is based) does not require a radical change in the practice of late abortions (constituting only 7% of the terminations) or any change in the law. PG abortion can be done without a nurse. With the extraamniotic technique, a very cheap pump can be used to give subsequent doses of the PG (a function normally performed by a nurse) through the catheter left inserted through the cervix after the 1st dose has been given by the doctor. Alternatively, the intraamniotic method can be used, where PG is instilled into the amniotic sac via a needle passed through the abdominal wall. This normally requires only 1 dose, given by the doctor. Rarely are subsequent doses needed; however they could be given by the doctor with very little addition to his or her workload. While the fact that PG abortion can be done without nurses is not realized, late abortion will be restricted, a situation which is entirely deplorable. Also deplorable are the comments of an antiabortion nature made by Lord Denning, over and above the legal ruling in his jurisdiction to make. His ruling, furthermore, seems to have been sufficiently confused for the Department of Health to withdraw its circular on abortion and await an interpretation before issuing another. PMID:6107800

  6. Abortion and Crime: A Review

    Theodore J. Joyce

    2009-01-01

    Ten years have passed since John Donohue and Steven Levitt initially proposed that legalized abortion played a major role in the dramatic decline in crime during the 1990s. Criminologists largely dismiss the association because simple plots of age-specific crime rates are inconsistent with a large cohort affect following the legalization of abortion. Economists, on the other hand, have corrected mistakes in the original analyses, added new data, offered alternative tests and tried to replicat...

  7. Kvinners reaksjoner etter spontan abort

    2012-01-01

    Background: Approximately 15 percent of all verified pregnancies end in miscarriage. It is known that spontaneous abortion often cause psychological distress. The women are at risk of suffering from grief, anxiety, depression and other psychological symptoms. Psychological symptoms could persist for years after the miscarriage and there is frequently no routine to identify psychiatric morbidity among the women. Research has been conducted to identify the consequences of abortion, but the stud...

  8. Conservation of Salmonella infection mechanisms in plants and animals

    Schikora, Adam; Virlogeux-Payant, Isabelle; Bueso, Edouardo; Garcia, Anna Victoria; Nilau, Theodora; Charrier, Amélie; Pelletier, Sandra; Menanteau, Pierrette; Baccarini, Manuela; Velge, Philippe; Hirt, Heribert

    2011-01-01

    Salmonella virulence in animals depends on effectors injected by Type III Secretion Systems (T3SSs). In this report we demonstrate that Salmonella mutants that are unable to deliver effectors are also compromised in infection of Arabidopsis thaliana plants. Transcriptome analysis revealed that in contrast to wild type bacteria, T3SS mutants of Salmonella are compromised in suppressing highly conserved Arabidopsis genes that play a prominent role during Salmonella infection of animals. We also...

  9. Abortion - a philosophical perspective

    MN Jali

    2001-09-01

    Full Text Available The central issue in the abortion debate is the moral status of the conceptus. There are two positions that argue this issue. At one extreme are the views of the pro-life group which argues that human life begins at the moment of conception whilst at the other are views of the pro-choice group that argues in favour of a woman’s right to self-determination. Two basic principles come into conflict in this debate, namely the Value of Life and that of Self-determination. In this paper the arguments forwarded by each group in justification of its position are presented. Also discussed is the moderate developmental viewpoint which accepts that the genetic basis of an individual is established at conception. Some development, however, has to occur before the conceptus can be called a person. The fact that an entity is a potential person is a prima facie reason for not destroying it. On the other hand, we need not conclude that a person has a right to life by virtue of that potentiality. Simultaneously we should recognise that the right a potential entity has, may be nullified by the woman’s right to self-determination.

  10. Evaluation of DNA extraction protocols for Brucella abortus pcr detection in aborted fetuses or calves born from cows experimentally infected with strain 2308 Avaliação de diferentes protocolos de extração de DNA para detecção de Brucella abortus a partir de abortos ou de bezerros nascidos de vacas experimentalmente infectadas com estirpe 2308

    M. Matrone

    2009-09-01

    Full Text Available The objective of the present study was to improve the detection of B. abortus by PCR in organs of aborted fetuses from infected cows, an important mechanism to find infected herds on the eradication phase of the program. So, different DNA extraction protocols were compared, focusing the PCR detection of B. abortus in clinical samples collected from aborted fetuses or calves born from cows challenged with the 2308 B. abortus strain. Therefore, two gold standard groups were built based on classical bacteriology, formed from: 32 lungs (17 positives, 26 spleens (11 positives, 23 livers (8 positives and 22 bronchial lymph nodes (7 positives. All samples were submitted to three DNA extraction protocols, followed by the same amplification process with the primers B4 and B5. From the accumulated results for organ, the proportion of positives for the lungs was higher than the livers (p=0.04 or bronchial lymph nodes (p=0.004 and equal to the spleens (p=0.18. From the accumulated results for DNA extraction protocol, the proportion of positives for the Boom protocol was bigger than the PK (pO objetivo do presente estudo foi aperfeiçoar a detecção de Brucella abortus pela PCR em homogeneizados de órgãos de fetos abortados por vacas infectadas, importante mecanismo para descobrir focos da doença na fase de erradicação. Assim, foram comparados diferentes protocolos de extração de DNA, visando à detecção de B. abortus pela PCR em amostras clínicas colhidas de abortos ou de bezerros oriundos de vacas desafiadas com a estirpe 2308 de B. abortus. Para tanto, foram construídos dois grupos padrão ouro com base na bacteriologia clássica, constituídos por: 32 pulmões (17 positivos, 26 baços (11 positivos, 23 fígados (8 positivos e 22 linfonodos bronquiais (7 positivos. Todas essas amostras foram submetidas a três protocolos de extração de DNA, seguidos do mesmo processo de amplificação com os primers B4 e B5. Nos resultados acumulados por

  11. An epidemiologic study of late-term abortions in dairy cattle in Denmark, July 2000 August 2003

    Carpenter, Tim E.; Chriél, Mariann; Andersen, Mette M.;

    2006-01-01

    .11) risk of increased abortions was found to exist in bovine viral diarrhea virus-(BVDV) infected herds, it could be at least partially explained by additional calvings in those herds. Temporal correlation between inseminations and abortions was statistically significant (P <0.001) with the highest...

  12. [Readers' position against induced abortion].

    1981-08-25

    Replies to the request by the Journal of Nursing on readers' positions against induced abortion indicate there is a definite personal position against induced abortion and the assistance in this procedure. Some writers expressed an emotional "no" against induced abortion. Many quoted arguments from the literature, such as a medical dictionary definition as "a premeditated criminally induced abortion." The largest group of writers quoted from the Bible, the tenor always being: "God made man, he made us with his hands; we have no right to make the decision." People with other philosophies also objected. Theosophical viewpoint considers reincarnation and the law of cause and effect (karma). This philosophy holds that induced abortion impedes the appearance of a reincarnated being. The fundamental question in the abortion problem is, "can the fetus be considered a human life?" The German anatomist Professor E. Bleckschmidt points out that from conception there is human life, hence the fertilized cell can only develop into a human being and is not merely a piece of tissue. Professional nursing interpretation is that nursing action directed towards killing of a human being (unborn child) is against the nature and the essence of the nursing profession. A different opinion states that a nurse cares for patients who have decided for the operation. The nurse doesn't judge but respects the individual's decision. Some proabortion viewpoints considered the endangering of the mother's life by the unborn child, and the case of rape. With the arguments against abortion the question arises how to help the woman with unwanted pregnancy. Psychological counseling is emphasized as well as responsible and careful assistance. Referral to the Society for Protection of the Unborn Child (VBOK) is considered as well as other agencies. Further reader comments on this subject are solicited. PMID:6913282

  13. House subcmte. tightens abortion language.

    1978-05-10

    Medicaid would help pay for abortion in fewer circumstances under the fiscal 1979 Department of Health, Education, and Welfare (HEW), appropriations bill approved May 4, 1978, by the House HEW Appropriations Subcommittee than it did in 1978. The new language would permit the funding only if the mother's life would be endangered if the pregnancy were carried to term. Current law permits abortion payments for this reason; if pregnancy results from rape or incest, or if the birth would cause the mother severe and long-lasting physical damage. Behind the scenes pressure probably will be applied to resolve the issue quickly this year since all House members are up for reelection and do not want to have such a sensitive issue intruding on their campaigns. 1 strategy being discussed is the inclusion of riders that would directly or indirectly provide federal funds for abortions in other appropriation measures such as funding for the Defense Department and federal employees health benefits. The House will have to contend with Senator Brooke (R-Massachusetts) ranking minority member on the Senate HEW Appropriations Subcommittee, who is determined to stand firm in favor of liberal abortion funding. With only minimal opposition for his Senate seat this year, Senate staffers say Brooke is not concerned with the possibility of abortion becoming a major campaign issue. It was Brooke who forced the House's hand last year and obtained a more relaxed abortion curb, much to the chagrin of the Carter Administration. The White House, with the President's popularity at a low ebb, would prefer not to be put in a position of taking sides publicly although it prefers the strict curbs. Carter is currently deciding which House members to assist during the campaign and such a no-win issue would only serve to complicate matters. He will have enough of a problem reconciling health spending increases without the added burden of abortion. PMID:12335662

  14. Hospital admission following induced abortion in Eastern Highlands Province, Papua New Guinea--a descriptive study.

    Lisa M Vallely

    Full Text Available In Papua New Guinea abortion is restricted under the Criminal Code Act. While safe abortions should available in certain situations, frequently they are not available to the majority of women. Sepsis from unsafe abortion is a leading cause of maternal mortality. Our findings form part of a wider, mixed methods study designed to identify complications requiring hospital treatment for post abortion care and to explore the circumstances surrounding unsafe abortion.Through a six month prospective study we identified all women presenting to the Eastern Highlands Provincial Hospital following spontaneous and induced abortions. We undertook semi-structured interviews with women and reviewed individual case notes, extracting demographic and clinical information.Case notes were reviewed for 56% (67/119 of women presenting for post abortion care. At least 24% (28/119 of these admissions were due to induced abortion. Women presenting following induced abortions were significantly more likely to be younger, single, in education at the time of the abortion and report that the baby was unplanned and unwanted, compared to those reporting spontaneous abortion. Obtained illegally, misoprostol was the method most frequently used to end the pregnancy. Physical and mechanical means and traditional herbs were also widely reported.In a country with a low contraceptive prevalence rate and high unmet need for family planning, all reproductive age women need access to contraceptive information and services to avoid, postpone or space pregnancies. In the absence of this, women are resorting to unsafe means to end an unwanted pregnancy, putting their lives at risk and putting an increased strain on an already struggling health system. Women in this setting need access to safe, effective means of abortion.

  15. Urinary Tract Infection Molecular Mechanisms and Clinical Translation.

    Godaly, Gabriela; Ambite, Ines; Puthia, Manoj; Nadeem, Aftab; Ho, James; Nagy, Karoly; Huang, Yujing; Rydström, Gustav; Svanborg, Catharina

    2016-01-01

    Rapid developments in infection biology create new and exciting options for individualized diagnostics and therapy. Such new practices are needed to improve patient survival and reduce morbidity. Molecular determinants of host resistance to infection are being characterized, making it possible to identify susceptible individuals and to predict their risk for future morbidity. Immunotherapy is emerging as a new strategy to treat infections worldwide and controlled boosting of the host immune defense represents an important therapeutic alternative to antibiotics. In proof of concept studies, we have demonstrated that this approach is feasible. The long-term goal is not just to remove the pathogens but to also develop technologies that restore resistance to infection in disease-prone patients and devise personalized therapeutic interventions. Here, we discuss some approaches to reaching these goals, in patients with urinary tract infection (UTI). We describe critical host signaling pathways that define symptoms and pathology and the genetic control of innate immune responses that balance protection against tissue damage. For some of these genes, human relevance has been documented in clinical studies, identifying them as potential targets for immune-modulatory therapies, as a complement to antibiotics. PMID:26927188

  16. Prevalence and diversity of Arcobacter spp. isolated from the internal organs of spontaneous porcine abortions in Denmark

    On, Stephen L.W.; Jensen, Tim Kåre; Bille-Hansen, Vivi; Jorsal, Sven Erik Lind; Vandamme, P.

    2002-01-01

    aborted fetuses from a single sow. The high prevalence of arcobacters in Danish pig abortions may account for at least some of the >90% of cases in which no established abortifacient agent is detected, but further studies are needed to define the role of each species, especially where co-infections with......A study was conducted to determine the prevalence and possible significance of campylobacteria in pig abortions in Denmark, Surface-cauterised liver and kidney samples from 55 aborted pig fetuses submitted to the Danish Veterinary Laboratory were taken and a sensitive isolation procedure used to...

  17. "Abortion? That's for women!" Narratives and experiences of commercial motorbike riders in south-western Uganda.

    Nyanzi, Stella; Nyanzi, Barbara; Bessie, Kalina

    2005-04-01

    Although constitutionally illegal, induced abortion is a vital reproductive health option in Uganda. This paper analyses men's narratives about meanings of, and experiences with, abortion. Men play significant roles in abortion as instigators, facilitators, collaborators, transporters, advisors, informers, supporters or punishment givers. Many participants were knowledgeable about abortion. Attitudes were ambivalent, with initial reactions of denial and relegation of abortion to women's private domains. Further exploration, however, revealed active support and involvement of men. Interpretations of abortion ranged from 'dependable saviour' to 'deceptive sin'. Though a private action, abortion is socially scripted and often collectively determined by wider social networks of kinsmen, the community, peers, law and religion. A disjuncture exists between dominant public health discourse and the reality of local men who interact with women and girls as wives, lovers, sex sellers, mothers, daughters and sisters. Interventions targeting men about abortion should include safe sex education, provide safe abortion services and create stronger social support mechanisms. Policy and law should incorporate local knowledge and practice. PMID:16104664

  18. Serological differences in Neospora caninum-associated epidemic and endemic abortions.

    Schares, G; Rauser, M; Zimmer, K; Peters, M; Wurm, R; Dubey, J P; de Graaf, D C; Edelhofer, R; Mertens, C; Hess, G; Conraths, F J

    1999-08-01

    A sandwich enzyme-linked immunosorbent assay (ELISA) for the sensitive and specific detection of bovine antibodies to Neospora caninum was developed and evaluated using sera from cattle experimentally infected with N. caninum, Toxoplasma gondii, Sarcocystis cruzi, Sarcocystis hominis, Sarcocystis hirsuta, Eimeria bovis, Cryptosporidium parvum, Babesia divergens, and field sera from naturally exposed animals. Field sera were classified using a gold standard that included the results from an indirect fluorescent antibody test (IFAT) and an immunoblot (IB). Based on these gold standard results, i.e., IFAT-IB results, an equal relative sensitivity and specificity of 94.2%(theta0) was reached when a cutoff of 0.034 (d0) was employed. The analysis of IFAT-IB-positive field sera showed that within groups of aborting and nonaborting dams, the animals from herds with endemic N. caninum-associated abortions had significantly higher ELISA indices than animals from herds with N. caninum-associated epidemic abortions. By contrast, IFAT-IB-positive aborting dams from herds with endemic N. caninum-associated abortions had significantly lower IFAT titers than IFAT-IB-positive aborting dams from herds with epidemic N. caninum-associated abortions. This is the first time that statistically significant serological differences between herds exhibiting epidemic and endemic N. caninum-associated abortions are described. PMID:10461950

  19. Abortion and the law: the Supreme Court, privacy, and abortion.

    Marsh, F H

    1997-01-01

    This article examines the impact of the continuing politicization of the abortion issue in the US on the rights of women and on the emerging concept of fetal rights. The introduction 1) attributes the "final and total politicization" of a woman's right to control her reproduction to the "undue burden" standard introduced by the Supreme Court in its 1992 Casey decision and 2) claims that, if unchecked, the concept of fetal rights may give the state's interest in protecting potential life supremacy over women's rights. The next section presents an in-depth discussion of the politicization of the right to abortion that covers such topics as how the courts before Casey became the forum for debating abortion policy, how the "undue burden" standard fails to set definite parameters of acceptable state behavior, how the Casey decision in effect abandons the trimester-based framework of reference provided in Roe vs. Wade, how Casey allows states to subtly coerce women seeking abortions, how the Casey decision failed to reduce the intense politicization of abortion, and how the court failed to protect individual rights to health care and abortion funding from states. Part 3 of the article begins its exploration of the concept of "fetal rights" with a sketch of the history of this concept in the US courts starting in 1884 when damages for miscarriage were denied. Ways in which fetal rights compete with the rights of a pregnant woman are described, the Supreme Court is blamed for allowing states to develop this concept, and issues of patient confidentiality versus reporting requirements are considered. It is concluded that the Supreme Court will have to act to limit fetal rights. PMID:12348324

  20. Glycolytic control of vacuolar-type ATPase activity: A mechanism to regulate influenza viral infection

    Kohio, Hinissan P.; Adamson, Amy L., E-mail: aladamso@uncg.edu

    2013-09-15

    As new influenza virus strains emerge, finding new mechanisms to control infection is imperative. In this study, we found that we could control influenza infection of mammalian cells by altering the level of glucose given to cells. Higher glucose concentrations induced a dose-specific increase in influenza infection. Linking influenza virus infection with glycolysis, we found that viral replication was significantly reduced after cells were treated with glycolytic inhibitors. Addition of extracellular ATP after glycolytic inhibition restored influenza infection. We also determined that higher levels of glucose promoted the assembly of the vacuolar-type ATPase within cells, and increased vacuolar-type ATPase proton-transport activity. The increase of viral infection via high glucose levels could be reversed by inhibition of the proton pump, linking glucose metabolism, vacuolar-type ATPase activity, and influenza viral infection. Taken together, we propose that altering glucose metabolism may be a potential new approach to inhibit influenza viral infection. - Highlights: • Increased glucose levels increase Influenza A viral infection of MDCK cells. • Inhibition of the glycolytic enzyme hexokinase inhibited Influenza A viral infection. • Inhibition of hexokinase induced disassembly the V-ATPase. • Disassembly of the V-ATPase and Influenza A infection was bypassed with ATP. • The state of V-ATPase assembly correlated with Influenza A infection of cells.

  1. Glycolytic control of vacuolar-type ATPase activity: A mechanism to regulate influenza viral infection

    As new influenza virus strains emerge, finding new mechanisms to control infection is imperative. In this study, we found that we could control influenza infection of mammalian cells by altering the level of glucose given to cells. Higher glucose concentrations induced a dose-specific increase in influenza infection. Linking influenza virus infection with glycolysis, we found that viral replication was significantly reduced after cells were treated with glycolytic inhibitors. Addition of extracellular ATP after glycolytic inhibition restored influenza infection. We also determined that higher levels of glucose promoted the assembly of the vacuolar-type ATPase within cells, and increased vacuolar-type ATPase proton-transport activity. The increase of viral infection via high glucose levels could be reversed by inhibition of the proton pump, linking glucose metabolism, vacuolar-type ATPase activity, and influenza viral infection. Taken together, we propose that altering glucose metabolism may be a potential new approach to inhibit influenza viral infection. - Highlights: • Increased glucose levels increase Influenza A viral infection of MDCK cells. • Inhibition of the glycolytic enzyme hexokinase inhibited Influenza A viral infection. • Inhibition of hexokinase induced disassembly the V-ATPase. • Disassembly of the V-ATPase and Influenza A infection was bypassed with ATP. • The state of V-ATPase assembly correlated with Influenza A infection of cells

  2. The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis.

    Fauci, Anthony S.

    1988-01-01

    Discusses how the infection of the human immunodeficiency virus (HIV) results in a profound immunosuppression due predominantly to a selective depletion of helper/inducer T lymphocytes that express the receptor for the virus, as well as neuropsychiatric abnormalities in the brain. (TW)

  3. Expression of Ki-67, Bcl-2 and Bax in the First Trimester Abortion Materials

    Ender DÜZCAN

    2010-01-01

    Full Text Available Objective: The aim of this study was to investigate possible similar or different mechanisms in recurrent and spontaneous abortion by evaluating immunohistochemical correlation between proliferation marker Ki-67, and apoptosis markers Bcl-2 and Bax in the fetal trophoblasts and maternal deciduas from abortion material.Material and Method: Eighty samples of curettage materials from 65 abortion patients histopathologically diagnosed “decidua showing Arias-Stella reaction and chorionic villi” or only “decidua showing Arias-Stella reaction” were included in the study. Hematoxylin&Eosin stained sections from all cases were re-evaluated and further stained immunohistochemically using antibodies against Ki-67, Bcl-2 and Bax.Results: Proliferation rate evaluated by Ki-67 expression both in the cytotrophoblastic cells and decidua was found to be significantly lower in spontaneous and recurrent abortions compared to evacuation abortion. The extent of Bcl-2 expression in syncytiotrophoblastic cells covering villous stroma was also decreased in spontaneous abortion. There were no significant differences between spontaneous and recurrent abortions in terms of Bcl-2 expression in syncytiotrophoblasts and Ki-67 proliferation index in cytotrophoblastic cells or decidua. Bax staining showed minimal decidual expression in a few spontaneous and recurrent abortions.Conclusion: We concluded that proliferation rate was decreased in fetal villous cytotrophoblasts and maternal deciduas in spontaneous and recurrent abortions. We also proposed that loss of Bcl-2 expression in syncytiotrophoblasts may cause abortion in a subset of cases. However, the data from spontaneous and recurrent abortions did not not support the presence of different mechanisms in both groups.

  4. Year in review 2005: Critical Care – Respirology: mechanical ventilation, infection, monitoring, and education

    Haitsma, Jack J; Villar, Jesús; Slutsky, Arthur S.

    2006-01-01

    We summarize all original research in the field of respiratory intensive care medicine published in 2005 in Critical Care. Twenty-seven articles were grouped into the following categories and subcategories to facilitate rapid overview: mechanical ventilation (physiology, spontaneous breathing during mechanical ventilation, high frequency oscillatory ventilation, side effects of mechanical ventilation, sedation, and prone positioning); infection (pneumonia and sepsis); monitoring (ventilatory ...

  5. Study of karyotypes in Case of Recurrent Abortions in Gujarat

    N. Parikh

    2015-06-01

    Full Text Available Introduction: - The biological definition of miscarriage is the expulsion of the conceptus before viability has been achieved. The definition of recurrent miscarriage is three or more consecutive spontaneous abortions. The risk factors for recurrent miscarriage are epidemiological, genetic, anatomical disorders, endocrinal, reproductive tract infections, thrombophilic disorders, disorders of materno-fetal alloimmune relationships, environmental effects and psychological causes. About 50% to 60% of all first trimester abortions are associated with derangement of one or more chromosomal complements. Aim: - The aim of this study was to assess frequency and increasing the awareness of physician about the nature of chromosomal aberration that contribute to the occurrence of repeated abortions. Material & Methods: - Patient of recurrent abortion was investigated by history taking, examination and investigations. For present study 20 women having two or more consecutive spontaneous abortions, who attended outdoor & indoor patient department, were selected and karyotyping was done. In 10 of the above cases karyotype study of both partners was done. So in total 30 individuals (20 females & 10 males were selected for Cytogenetic study. In all cases relevant history and clinical findings and other investigations were noted. Blood samples were obtained and karyotype study was performed at Genetic Laboratory, B. J. Medical College, Ahmedabad. Results and Conclusions: - Cytogenetic evaluation by karyotypes revealed robertsonian translocation in one (5% female; this patient had a history of 2 spontaneous abortions and two times IVF failure, she had history of chocolate cyst of ovary and family history of infertility. No numerical anomaly; mosaicism or inversions were found in this study; 23 cases had normal karyotype and remaining 6 cases came out inconclusive.

  6. New clues underlying mechanism of HIV infection in pig-tailed macaques

    2008-01-01

    @@ Recent studies made by CAS scientists may shed new light on a novel approach to demystifying the complicated pathogenesis of AIDS, i.e., the formative mechanism of HIV infection at the molecular level.

  7. Abortion counseling and the school counselor.

    Duncan, J A; Moffett, C F

    1974-01-01

    The Supreme Court decision of January 22, 1973, legalizing abortion now requires school counselors to examine both their personal and professional positions on abortion information and abortion counseling. To date a review of school counseling literature reveals a failure to deal with abortion as a counseling issue. Also, schools have failed to develop official policies regarding abortion counseling and the distribution of abortion information. The counselors who have provided abortion information to date have done so at the request of a student or parent rather than by making the information generally available. A study in 1973 in Virginia, however, revealed that Virginia counselor educators believed that there was a need for counselors in training to be exposed to abortion information as part of their formal training experience. Generally, today's present exposure to abortion information makes it impossible for counselors to continue to ignore a growing demand for both abortion information and counseling. School counselors must deal with the following questions: 1) What course of action should school counselors take when a pregnant young seeks counseling on alternatives to pregnancy continuation? 2) What is the counselor's professional role in abortion counseling with respect to his or her personal feelings and beliefs? 3) What kind of training if any should school counselors receive regarding abortion counseling? 4) Is there a need for in-service training on abortion counseling for school counselors? 5) Should various professional organizations develop materials that would assist their members in providing abortion counseling? 6) Should institutions such as schools, churches, and community agencies establish policies concerning abortion counseling? Although the answers are not simple, the school counselors and their professional organizations must begin to develop the answers in order to provide good counseling services to young women exercising their right to

  8. Abortion in Iranian legal system: a review.

    Mahmoud Abbasi; Ehsan Shamsi Gooshki; Neda Allahbedashti

    2014-01-01

    Abortion traditionally means, "to miscarry" and is still known as a problem which societies has been trying to reduce its rate by using legal means. Despite the pregnant women and fetuses have being historically supported; abortion was firstly criminalized in 1926 in Iran, 20 years after establishment of modern legal system. During next 53 years this situation changed dramatically, so in 1979, the time of Islamic Revolution, aborting fetuses before 12 weeks and therapeutic abortion (TA) durin...

  9. Clinical observations and management of a severe equine herpesvirus type 1 outbreak with abortion and encephalomyelitis

    Walter, Jasmin; Seeh, Christoph; Fey, Kerstin; Bleul, U; Osterrieder, Nikolaus

    2013-01-01

    Latent equine herpesvirus type 1 (EHV-1) infection is common in horse populations worldwide and estimated to reach a prevalence nearing 90% in some areas. The virus causes acute outbreaks of disease that are characterized by abortion and sporadic cases of myeloencephalopathy (EHM), both severe threats to equine facilities. Different strains vary in their abortigenic and neuropathogenic potential and the simultaneous occurrence of EHM and abortion is rare. In this report, we present clinical o...

  10. Mechanisms of recrudescence of Mycobacterium bovis BCG infection in mice.

    Cox, J H; Knight, B. C.; Ivanyi, J.

    1989-01-01

    The capacity of various immunosuppressive agents to cause a recrudescence of the replication of Mycobacterium bovis BCG in the spleens of chronically infected mice was investigated. The actions of three corticosteroid preparations, cyclosporin A, and anti-T-cell subset monoclonal antibodies were compared. Treatment of mice with hydrocortisone acetate, which depressed the number of splenic lymphocytes and suppressed T-cell responses, most effectively exacerbated the stationary BCG counts, at 4...

  11. The Role of Urogenital Infection in the Mechanism of Infertility Development

    Shevchenko E.A.

    2011-06-01

    Full Text Available The aim of the study is to assess the role of urogenital infection in the mechanisms of infertility development. Materials and Methods. To diagnose urogenital infection agents, polymerase chain reaction technique in real time has been used. Results. There has been determined a statistically significant absence of differences in the groups of infertile and fertile patients according to the frequency of occurrence of urogenital infection agents studied. The bare fact that there is urogenital infection is not a cause and a triggering element of infertility pathogenesis.

  12. Abortion and Mental Health: Evaluating the Evidence

    Major, Brenda; Appelbaum, Mark; Beckman, Linda; Dutton, Mary Ann; Russo, Nancy Felipe; West, Carolyn

    2009-01-01

    The authors evaluated empirical research addressing the relationship between induced abortion and women's mental health. Two issues were addressed: (a) the relative risks associated with abortion compared with the risks associated with its alternatives and (b) sources of variability in women's responses following abortion. This article reflects…

  13. Abortion, Moral Maturity and Civic Journalism.

    Patterson, Maggie Jones; Hall, Megan Williams

    1998-01-01

    Contributes to rhetoric, moral reasonings scholarship, and journalism scholarship by examining public rhetoric on abortion and American popular media coverage (1940s to 1990s). Finds that the feminine means of moral reasoning has emerged into the foreground of discourse on abortion. Compares emergence of a common-ground rhetoric on abortion with a…

  14. Remembering Aborted Foetuses in a Japanese Shrine

    Macfarlane, Alan

    2004-01-01

    In a shrine beside a temple in Kyoto there are a large number of small effigies. They commemorate aborted foetuses. In the absence of proper contraception, the Japanese for centuries have had to use abortion and, in the past, infanticide to control their population. These 'water children' (who return to the water world at abortion) are a source of great sadness in Japan.

  15. "If a woman has even one daughter, I refuse to perform the abortion": Sex determination and safe abortion in India.

    Potdar, Pritam; Barua, Alka; Dalvie, Suchitra; Pawar, Anand

    2015-05-01

    In India, safe abortion services are sought mainly in the private sector for reasons of privacy, confidentiality, and the absence of delays and coercion to use contraception. In recent years, the declining sex ratio has received much attention, and implementation of the Pre-Conception and Pre-Natal Diagnostic Techniques (PCPNDT) Act (2003) has become stringent. However, rather than targeting sex determination, many inspection visits target abortion services. This has led to many private medical practitioners facing negative media publicity, defamation and criminal charges. As a result, they have started turning women away not only in the second trimester but also in the first. Samyak, a Pune-based, non-governmental organization, came across a number of cases of refusal of abortion services during its work and decided to explore the experiences of private medical practitioners with the regulatory mechanisms and what happened to the women. The study showed that as a fallout from the manner of implementation of the PCPNDT Act, safe abortion services were either difficult for women to access or outright denied to them. There is an urgent need to recognize this impact of the current regulatory environment, which is forcing women towards illegal and unsafe abortions. PMID:26278839

  16. A method for quantifying mechanical properties of tissue following viral infection.

    Vy Lam

    Full Text Available Viral infection and replication involves the reorganization of the actin network within the host cell. Actin plays a central role in the mechanical properties of cells. We have demonstrated a method to quantify changes in mechanical properties of fabricated model three-dimensional (3D connective tissue following viral infection. Using this method, we have characterized the impact of infection by the human herpesvirus, cytomegalovirus (HCMV. HCMV is a member of the herpesvirus family and infects a variety of cell types including fibroblasts. In the body, fibroblasts are necessary for maintaining connective tissue and function by creating mechanical force. Using this 3D connective tissue model, we observed that infection disrupted the cell's ability to generate force and reduced the cumulative contractile force of the tissue. The addition of HCMV viral particles in the absence of both viral gene expression and DNA replication was sufficient to disrupt tissue function. We observed that alterations of the mechanical properties are, in part, due to a disruption of the underlying complex actin microfilament network established by the embedded fibroblasts. Finally, we were able to prevent HCMV-mediated disruption of tissue function by the addition of human immune globulin against HCMV. This study demonstrates a method to quantify the impact of viral infection on mechanical properties which are not evident using conventional cell culture systems.

  17. U.S. adults' pornography viewing and support for abortion: a three-wave panel study.

    Tokunaga, Robert S; Wright, Paul J; McKinley, Christopher J

    2015-01-01

    Pornography consumption may affect judgments on a wide range of sexual and reproductive topics. The present study hypothesized that the consistent images projected in pornography affect sexual scripts related to abortion judgments. National, three-wave longitudinal data gathered from U.S. adults were employed to examine associations between earlier pornography consumption and subsequent support for abortion. The findings suggested that prior pornography consumption may lead to later support for abortion. This study provides additional evidence of pornography's socializing impact, particularly for the older White segment of the population, and adds to knowledge about what environmental factors influence judgments about abortion. Mechanisms that may explain how pornography viewing shapes support for abortion are discussed. PMID:25010599

  18. Bowel injuries secondary to induced abortion: a dilemma

    To study the pattern of bowel injuries incurred by induced abortion, and the morbidity and mortality associated with them. All patients with bowel injuries due to induced abortion. Detailed data of all the patients was collected and analyzed. A total of 22 patients, mostly young with an average age of 26.86 years, presented with bowel injuries following induced abortion. Severe hemorrhage occurred in 8(36.4%) patients while 11(50%) had ileal perforation; 9(40.9%) underwent primary repair and 2(9.1%) ileostomy formation. Two (9.1%) patients with jejunal perforation had primary repair, whereas two with both jejunal and ileal perforations underwent resections with anastomosis in one and ileostomy in another. Seven (31.8%) with large gut involvement had colostomy formation. Septicemia and wound infection occurred in 7(31.8%) patients each, faecal fistula and abdominal wound dehiscence in 3(13.6%), and pelvic abscess in 1(4.6%) patient. The total mortality in this series was 6(27.3%) patients. Iatrogenic injuries during induced abortion, most commonly caused by quacks, can be minimized substantially if the procedure is performed by qualified medical personnel in proper health care facilities. There is a need for radical overhauling of the mind set in our society together with legislation. (author)

  19. Seventeen years of legalized abortion in Singapore.

    Saw, S

    1988-06-01

    "In this paper we first discuss the two-stage process of legalizing induced abortion in Singapore, the initial legalization to make it available on a restrictive basis in 1970 and the complete liberalization to make it available on demand from 1975 onwards. The incidence of abortions registered in the last seventeen years and the major characteristics of aborters are analysed. The impact of abortion on the rapid decline of fertility to below-replacement level is highlighted, and the need to reduce abortion by amending the more liberal aspects of the law are considered at the end of the paper." PMID:12341971

  20. Sundhedspersonales holdninger til sene provokerede aborter varierer

    Christensen, Anne Vinggaard; Petersson, Birgit

    2012-01-01

    Internationale undersøgelser viser, at sene provokerede aborter skaber en større bekymring hos sundhedspersonale end tidlige aborter. Den største bekymring er risikoen for, at det aborterede foster udviser livstegn efter fødslen. Undersøgelser peger desuden på, at indikationen for abort, religiøs...... tilknytning og fagligt tilhørsforhold påvirker holdningerne. Antallet af sene provokerede aborter stiger i takt med, at fosterdiagnostikken udvikles, og der er derfor behov for forskning, der kan kaste lys over, hvordan det danske sundhedspersonale forholder sig til sene provokerede aborter....

  1. Vaccines and drugs against Neospora caninum, an important apicomplexan causing abortion in cattle and other farm animals

    Hemphill, Andrew

    2015-01-01

    Andrew Hemphill, Joachim Müller Institute of Parasitology, Vetsuisse Faculty, University of Bern, Bern, Switzerland Abstract: The apicomplexan parasite Neospora caninum represents an important abortion-causing parasite in cattle. The economic impact of neosporosis has led to considerable investments to develop vaccines that would prevent infection and abortion. Live-attenuated vaccines have been shown to confer some protection against N. caninum infection, but may cause problems due ...

  2. The calcification of staphylococcus aureus bacteria by the mineralization by inhibitor exclusion mechanism : a potential defense mechanism against bacterial infections

    Truong, Linh Y.

    2011-01-01

    The emergence of antibiotic resistant bacteria has become a worldwide concern. Our goal was to develop a new strategy to treat antibiotic resistant bacterial infections. We investigated whether bacteria are killed by the Mineralization by Inhibitor Exclusion (MIE) mechanism. This mechanism exploits the size exclusion characteristics of the bacterial cell wall, and therefore has no impact on mammalian cells. Our studies demonstrate that live Staphylococcus aureus are calcified by the MIE mecha...

  3. Survey of infectious etiologies of bovine abortion during mid- to late gestation in dairy herds.

    Barkallah, Mohamed; Gharbi, Yaakoub; Hassena, Amal Ben; Slima, Ahlem Ben; Mallek, Zouhir; Gautier, Michel; Greub, Gilbert; Gdoura, Radhouane; Fendri, Imen

    2014-01-01

    Bovine abortion of unknown infectious etiology still remains a major economic problem. Thus, we investigated whether Brucella spp., Listeria monocytogenes, Salmonella spp., Campylobacter spp. and Coxiella burnetii are associated with abortion and/or stillbirth in Tunisian dairy cattle. Using a pan-Chlamydiales PCR, we also investigated the role of Chlamydiaceae, Waddlia chondrophila, Parachlamydia acanthamoebae and other members of the Chlamydiales order in this setting. Veterinary samples taken from mid to late-term abortions from twenty dairy herds were tested. From a total of 150 abortion cases collected, infectious agents were detected by PCR in 73 (48.66%) cases, 13 (8.66%) of which represented co-infections with two infectious agents. Detected pathogens include Brucella spp (31.3%), Chlamydiaceae (4.66%), Waddlia chondrophila (8%), Parachlamydia acanthamoebae (5.33%), Listeria monocytogenes (4.66%) and Salmonella spp. (3.33%). In contrast, Campylobacter spp. and Coxiella burnetii DNA were not detected among the investigated veterinary samples. This demonstrates that different bacterial agents may cause bovine abortion in Tunisia. This is the first report suggesting the role of Parachlamydia acanthamoebae in bovine abortion in Africa. Further studies with a larger number of samples are necessary to confirm whether this emerging pathogen is directly linked to abortion in cattle. PMID:24662769

  4. Survey of infectious etiologies of bovine abortion during mid- to late gestation in dairy herds.

    Mohamed Barkallah

    Full Text Available Bovine abortion of unknown infectious etiology still remains a major economic problem. Thus, we investigated whether Brucella spp., Listeria monocytogenes, Salmonella spp., Campylobacter spp. and Coxiella burnetii are associated with abortion and/or stillbirth in Tunisian dairy cattle. Using a pan-Chlamydiales PCR, we also investigated the role of Chlamydiaceae, Waddlia chondrophila, Parachlamydia acanthamoebae and other members of the Chlamydiales order in this setting. Veterinary samples taken from mid to late-term abortions from twenty dairy herds were tested. From a total of 150 abortion cases collected, infectious agents were detected by PCR in 73 (48.66% cases, 13 (8.66% of which represented co-infections with two infectious agents. Detected pathogens include Brucella spp (31.3%, Chlamydiaceae (4.66%, Waddlia chondrophila (8%, Parachlamydia acanthamoebae (5.33%, Listeria monocytogenes (4.66% and Salmonella spp. (3.33%. In contrast, Campylobacter spp. and Coxiella burnetii DNA were not detected among the investigated veterinary samples. This demonstrates that different bacterial agents may cause bovine abortion in Tunisia. This is the first report suggesting the role of Parachlamydia acanthamoebae in bovine abortion in Africa. Further studies with a larger number of samples are necessary to confirm whether this emerging pathogen is directly linked to abortion in cattle.

  5. SELF - INDUCED MEDICAL ABORTION: A RISING CHALLENGE

    Bindoo

    2015-10-01

    Full Text Available In India medical abortion has become acceptable to the masses. As per the MTP Act 2003 medical abortion can be provided by certified providers at approved places or centres which have referral linkages even though the Centre is not approved for MTP. Despit e this in India a large number of abortions are still illegal. People are resorting to abortion without any pre - abortion checkup or counseling which is contrary to the MTP Act. This study was carried out to determine the reasons for resorting to self - induc ed abortion, assess the associated complications and acceptance of contraception after abortion. 77.7% of women in this study included those who reported to hospital following self - administered abortion so did not have any checkup, investigation or counsel ing. 23% women got the prescriptions from RMP, 42.85% from chemists and 30% from friend even though 55% of them were not residing far from the hospital. Following self - administered abortion, women reported with pain abdomen, retained products, pelvic infla mmatory disease and heavy bleeding requiring emergency suction evacuation. These women were not aware about the need for contraception and mistook self - induced abortion as a method for family planning. They resorted to self - induced abortions because they b elieved it to be safe, and presumed that a visit to the hospital is avoidable. 45 % of these women had undergone abortions in the past without any side effect. It is feared that if self - induced medical abortions continues unheeded the health system will get overburdened with resultant complications besides losing an opportunity for contraceptive counseling . It is recommended that the private practitioners may be brought into the system besides ensuring that regulations regarding prescription of drugs and the MTP Act are followed. Besides this masses should be made aware of the legality of medical abortion by using handouts and posters.

  6. Nasopharyngeal Tuberculosis: Epidemiology, Mechanism of Infection, Clinical Manifestations, and Management

    Chonticha Srivanitchapoom

    2016-01-01

    Full Text Available Nasopharyngeal tuberculosis (NPTB is a noteworthy disease especially in its worldwide spread of the Mycobacterium infection. Although NPTB has been identified in less than one percent of TB cases, recent multiple case reports indicate an either increased awareness or incidence of this disease. The most helpful diagnostic tool is an uncomplicated nasopharyngeal biopsy. However, NPTB is usually ignored because it has varied clinical manifestations and similar presentations with other more common head and neck diseases. Furthermore, the most common presenting symptom is cervical lymphadenopathy mimicking nasopharyngeal carcinoma, a more common and serious disease. Treatment outcomes of NPTB are good in both HIV-positive or HIV-negative patients. In addition, pulmonary tuberculosis association was reported in wide range between 8.3% and 82% which should be considered in a treatment program. In conclusion, early diagnosis and management in NPTB can be achieved by (1 increased awareness of this disease, (2 improvement in knowledge regarding clinical manifestations, and (3 improvement of diagnostic techniques.

  7. Seroprevalence study of the main causes of abortion in dairy cattle in Morocco.

    Lucchese, Laura; Benkirane, Abdelali; Hakimi, Imane; El Idrissi, Ahmed; Natale, Alda

    2016-03-31

    Sera from 221 cattle were collected in 25 farms in Morocco to investigate the evidence and circulation of some of the main bovine abortive agents in the dairy cattle farming, where abortions are often reported. All sera were examined for brucellosis, 176 for neosporosis, 88 for leptospirosis, and 42 for Bovine viral diarrhoea (BVD/MD), Bovine Herpesvirus 1 (BHV-1) (Infectious bovine rhinotracheitis, IBR/IPV), and Bovine Herpesvirus 4 (BHV-4) infections (at least 1 sample per herd). Abortions were reported in 23 (10.4%) of the 221 tested cattle. Antibodies against the investigated pathogens were detected in all samples tested, with an overall seroprevalence of 33.48% for Brucella, 9.09% for Leptospira, 8.52% for Neospora, 37.71% for BVDV, 50% for BHV-1, 9.52% for BHV-4. As for Leptospira antibodies against serovars Hardjo, Pomona, and Tarassovi were identi ed. Mixed infections were common. The lack of evidence of non-infectious factors epidemiologically related to abortions suggested that the investigated agents are to be considered important risk factors in the dynamic of the abortion syndrome, even if further investigations are necessary to identify the abortion cause. Particular attention should be paid on brucellosis, considering the high seroprevalence and its zoonotic relevance. PMID:27033527

  8. A prospective self-controlled study of fertility after second-trimester prostaglandin-induced abortion.

    MacKenzie, I Z; Fry, A

    1988-05-01

    One hundred forty women whose pregnancies were terminated in the second trimester with prostaglandins because of suspected fetal disease have been prospectively followed to assess their subsequent fertility. In six instances difficulties had been experienced in conceiving the pregnancy that was terminated. Since abortion 104 women have conceived, 97% within 24 months of abortion but in five instances after some delay. Only one woman had not succeeded in conceiving a wished-for pregnancy. There were no apparent differences in abortion management between those women readily conceiving and those in whom there was some delay, although termination because of chromosomal reasons or anatomic abnormalities was less commonly followed by another pregnancy as compared with those terminated for rubella or other viral infections. Reduced fertility after a late prostaglandin-induced abortion thus appears to be very infrequent. PMID:3369497

  9. A RETROSPECTIVE STUDY OF BOVINE ABORTIONS ASSOCIATED WITH BACILLUS-LICHENIFORMIS

    Agerholm, J.S.; Krogh, H.V.; Jensen, H.E.

    1995-01-01

    A retrospective study of bovine abortions associated with Bacillus licheniformis is described. The material consisted of 2445 bovine abortions submitted for diagnostics from 1986 through 1993. Initially, B, licheniformis had been isolated from 81 cases. Sections of these cases were reexamined...... microscopically and immunohistochemically by a PAP technique using a primary antibody against B, licheniformis. Of these abortions, 47 were most likely associated with B. licheniformis as tissue lesions with immunostained bacteria were present in these. In the remaining cases the diagnosis may not have been...... established due to the lack of sufficient materials, or the isolation of the bacterium was considered to be a result of contamination. In four cases concomitant infections with B, licheniformis and bovine virus diarrhoea virus were present. Abortions caused by B. licheniformis were predominantly seen during...

  10. SEROPREVALENCE OF TOXOPLASMA GONDII IN SPONTANEOUS ABORTIONS IN PREGNANT WOMEN

    Anubhuti

    2015-05-01

    Full Text Available INTRODUCTION: Toxoplasmosis is one of the diseases comprising the TORCH [ Toxoplasma gondii , Rubella virus , Cytomegalovirus , Herpes simplex virus] infections . It is known to cause perinatal death if the organism is acquired during pregnancy . Toxoplasmosis during pregnancy can cause congenital infection which may result in mental retardation and blindness in the infant . The present study aimed to evaluate the seroprevalence of Toxoplasma gondii and it i s associated risk facto rs among the women with history of spontaneous abortion . MATERIALS & METHODS: A total of 60 women with past or present history of spontaneous abortion and another 60 pregnant women without any bad obstetric history as control attending our hospital were in cluded in the study . All the serum samples were tested for the presence of specific Toxoplasma IgM and IgG antibodies using the On Site Toxo IgG/IgM Rapid Test strip , a lateral flow chromatographic immunoassay . RESULTS: Total seroprevalence of Toxoplasma gondii in the study was 12 . 5% . Total seropositivity in women with history of spontaneous abortion was 12 ( 20% and 3 ( 5% among control group . More number of seropositivity was observed among women between 26 to 30 years ( 60% . Risk factor of having cat a s pet animal had greater association of getting toxoplasmosis . CONCLUSION: This study revealed that the seroprevalence of toxoplasmosis was significantly high in the study population than in control group . There should be routine screening for antenatal wo men with bad obstetric history .

  11. Rejoinder to Wisniewski on Abortion

    Walter E. Block

    2010-11-01

    Full Text Available I have published more than just a few papers on the abortion issue. Instead of taking either the pro choice or the pro life position, I offer a third alternative: evictionism. I claim that this perspective, which, as it happens is a principled compromise between the other two positions, is the only one compatible with libertarianism. Wisniewski (2010 offers several not unreasonable challenges to my thesis. The present paper is my attempt to refute each and every one of them.

  12. Rejoinder to Wisniewski on Abortion

    Walter E. Block

    2010-01-01

    I have published more than just a few papers on the abortion issue. Instead of taking either the pro choice or the pro life position, I offer a third alternative: evictionism. I claim that this perspective, which, as it happens is a principled compromise between the other two positions, is the only one compatible with libertarianism. Wisniewski (2010) offers several not unreasonable challenges to my thesis. The present paper is my attempt to refute each and every one of them.

  13. Expectant Fathers, Abortion, and Embryos.

    Purvis, Dara E

    2015-01-01

    One thread of abortion criticism, arguing that gender equality requires that men be allowed to terminate legal parental status and obligations, has reinforced the stereotype of men as uninterested in fatherhood. As courts facing disputes over stored pre-embryos weigh the equities of allowing implantation of the pre-embryos, this same gender stereotype has been increasingly incorporated into a legal balancing test, leading to troubling implications for ART and family law. PMID:26242955

  14. [Request for abortion during the 2d pregnancy trimester].

    Treffers, P E; Van den Berg, G R; Jager-van Gelder, P A; Van Oenen, J J

    1976-12-18

    156 women, 12-20 weeks pregnant, applied for abortion at the Wilhelmo Clinic in Amsterdam; 102 abortions were granted. The 156 late-abortion seekers were compared with 282 early-abortion seekers and 490 pregnant women. The late-abortion seekers were significantly younger (P .05). A significantly greater number of women over 30 applied for early abortion (P .001). Unmarried or divorced women were more likely to apply to abortion (P .001). Nulliparae applied more frequently for late abortion, compared to early-abortion seekers (P .001). Women with only one child were more likely to be in the pregnancy group (p .05), with 2 children in the early-abortion group (p .001). Women from Surinam and the Antilles were more likely to be in the early abortion group (p .001). Of the late-abortion seekers, 9 had medical indications. Many had psychosocial problems; 91 had problems with partner relations. In 24 cases the delay in seeking abortion was due to a doctor. An ambivalent attitude toward the abortion existed in 22 of the patients. 83% of the late-abortion seekers and 11.3% of the early-abortion seekers had previously had an abortion. The contraceptive use of the late-abortion seekers was not regular. 1.3% of the late-abortion seekers and 9.9% of the early-abortion seekers were using IUDs at the time of conception. PMID:1012384

  15. Infection

    ... Potential Hazards Exposure of employees to community and nosocomial infections, e.g., Methicillin-resistant Staphylococcus aureus (MRSA) . Nosocomial infections are infections that occur from exposure to infectious ...

  16. An outpatient regimen of combined oral mifepristone 400 mg and misoprostol 400 microg for first-trimester legal medical abortion

    Ravn, Pernille; Rasmussen, Ase; Knudsen, Ulla Breth; Kristiansen, Frank Vous

    2005-01-01

    AIM: To evaluate the success rate of medical abortion using an outpatient regimen of oral mifepristone 400 mg and oral misoprostol 400 microg for legal abortion in women < 56 days pregnant. METHODS: Successful abortion was defined as an endometrial thickness < 20 mm evaluated by transvaginal...... procedure over a 3-year period and 606 (92%) experienced successful medical abortion. The remaining 8% had vacuum aspiration performed mainly due to uterine retention (70%). Other reasons were vaginal bleeding (25%), vomiting (2%), or pelvic infection (4%). Most women reported no days with severe pain (67......%), 0--1 days with moderate pain (82%), and 0--1 days with light pain (62%). In terms of gastrointestinal side effects, 68% reported nausea, 33% vomiting, and 27% diarrhea. Most women (90%) felt that the information given at the hospital prior to the abortion was sufficient, 74% would prefer medical...

  17. Abortion in Sri Lanka: The Double Standard

    2013-01-01

    In Sri Lanka, women do not have access to legal abortion except under life-saving circumstances. Clandestine abortion services are, however, available and quite accessible. Although safe specialist services are available to women who can afford them, others access services under unsafe and exploitative conditions. At the time of this writing, a draft bill that will legalize abortion in instances of rape, incest, and fetal abnormalities awaits approval, amid opposition. In this article, I explore the current push for legal reform as a solution to unsafe abortion. Although a welcome effort, this amendment alone will be insufficient to address the public health consequences of unsafe abortion in Sri Lanka because most women seek abortions for other reasons. Much broader legal and policy reform will be required. PMID:23327236

  18. Abortion in Sri Lanka: the double standard.

    Kumar, Ramya

    2013-03-01

    In Sri Lanka, women do not have access to legal abortion except under life-saving circumstances. Clandestine abortion services are, however, available and quite accessible. Although safe specialist services are available to women who can afford them, others access services under unsafe and exploitative conditions. At the time of this writing, a draft bill that will legalize abortion in instances of rape, incest, and fetal abnormalities awaits approval, amid opposition. In this article, I explore the current push for legal reform as a solution to unsafe abortion. Although a welcome effort, this amendment alone will be insufficient to address the public health consequences of unsafe abortion in Sri Lanka because most women seek abortions for other reasons. Much broader legal and policy reform will be required. PMID:23327236

  19. Further Tests of Abortion and Crime

    Ted Joyce

    2004-01-01

    The inverse relationship between abortion and crime has spurred new research and much controversy. If the relationship is causal, then polices that increased abortion have generated enormous external benefits from reduced crime. In previous papers, I argued that evidence for a casual relationship is weak and incomplete. In this paper, I conduct a number of new analyses intended to address criticisms of my earlier work. First, I examine closely the effects of changes in abortion rates between ...

  20. Abortion Counselling in Britain: Understanding the Controversy

    Hoggart, Lesley

    2015-01-01

    This article reviews literature from a number of disciplines in order to provide an explanation of the political controversy attached to the provision of abortion counselling. It will show how this is an area of health policy debate in which women's reproductive bodies have become a setting for political struggle. The issue of abortion counselling in Britain has undergone a number of discursive shifts in response to political manoeuvring and changing socio-legal framing of abortion. In partic...

  1. [Diagnosis and epidemiology of Neospora caninum-associated abortions in cattle].

    Conraths, F J; Schares, G

    1999-05-01

    Neospora caninum, a recently discovered protozoan parasite closely related to Toxoplasma gondii, has world-wide been recognized as an important cause of bovine abortion. N. caninum possesses a wide host range. The dog can be a definitive host for N. caninum. In cattle, the infection is transmitted transplacentally with high efficiency, while the majority of congenitally infected calves is clinically normal at birth and thereafter. Whether horizontal transmission occurs in cattle and whether this potential mode of transmission has epidemiological significance, remains to be elucidated. N. caninum-associated abortions can occur in epidemic or endemic form in a herd. The clinical symptoms of bovine neosporosis are confined to the occurrence of abortion, stillbirth and weak calves. Multifocal nonsuppurative encephalitis represents the most frequent pathohistological finding in N. caninum-associated abortions. The causative agent can be demonstrated by immunohistochemistry or polymerase chain reaction. Serological techniques can be used for indirect diagnosis. On the basis of the available diagnostic methods and the present knowledge about the epidemiology of the infection proposals are made regarding diagnosis, epidemiological assessment and prophylaxis of N. caninum-associated abortion problems in cattle herds. PMID:10384703

  2. The abortion battle: the Canadian scene.

    Sachdev, P

    1994-01-01

    In January 1988 the Supreme Court of Canada struck down the country's archaic abortion law on the ground that it imposed arbitrary delays and unfair disparities in access to abortion across the country. Since then, the conservative government of Canada has made a few attempts to introduce a new abortion policy, but it did not get passed in the parliament because the revised bills failed to protect women's right to 'life, liberty, and security of the person' within the meaning of the Canadian Charter. Canada has been without an abortion law for over four years and there has been a wide range of provincial policies and confusion in the country. Despite the legal vacuum, Canadian women are not frenziedly having abortions. However, the militancy of the anti-abortion groups has steadily intensified with continued assault on a woman's right to make reproductive choices. Since no law, short of banning abortions altogether, is going to satisfy abortion opponents, the abortion battle will rage on in Canada. PMID:8065237

  3. Abortion in Iranian legal system: a review.

    Mahmoud Abbasi

    2014-02-01

    Full Text Available Abortion traditionally means, "to miscarry" and is still known as a problem which societies has been trying to reduce its rate by using legal means. Despite the pregnant women and fetuses have being historically supported; abortion was firstly criminalized in 1926 in Iran, 20 years after establishment of modern legal system. During next 53 years this situation changed dramatically, so in 1979, the time of Islamic Revolution, aborting fetuses before 12 weeks and therapeutic abortion (TA during all the pregnancy length was legitimate, based on regulations that used medical justification. After 1979 the situation changed into a totally conservative and restrictive approach and new Islamic concepts as "Blood Money" and "Ensoulment" entered the legal debates around abortion. During the next 33 years, again a trend of decriminalization for the act of abortion has been continuing. Reduction of punishments and omitting retaliation for criminal abortions, recognizing fetal and maternal medical indications including some immunologic problems as legitimate reasons for aborting fetuses before 4 months and omitting the fathers' consent as a necessary condition for TA are among these changes. The start point for this decriminalization process was public and professional need, which was responded by religious government, firstly by issuing juristic rulings (Fatwas as a non-official way, followed by ratification of "Therapeutic Abortion Act" (TAA and other regulations as an official pathway. Here, we have reviewed this trend of decriminalization, the role of public and professional request in initiating such process and the rule-based language of TAA.

  4. Abortion Decision and Ambivalence: Insights via an Abortion Decision Balance Sheet

    Allanson, Susie

    2007-01-01

    Decision ambivalence is a key concept in abortion literature, but has been poorly operationalised. This study explored the concept of decision ambivalence via an Abortion Decision Balance Sheet (ADBS) articulating reasons both for and against terminating an unintended pregnancy. Ninety-six women undergoing an early abortion for psychosocial…

  5. Medical abortion practices : a survey of National Abortion Federation members in the United States

    Wiegerinck, Melanie M. J.; Jones, Heidi E.; O'Connell, Katharine; Lichtenberg, E. Steve; Paul, Maureen; Westhoff, Carolyn L.

    2008-01-01

    Background: Little is known about clinical implementation of medical abortion in the United States following approval of mifepristone as an abortifacient by the Food and Drug Administration (FDA) in 2000. We collected information regarding medical abortion practices of National Abortion Federation (

  6. Chest radiological patterns predict the duration of mechanical ventilation in children with RSV infection

    RSV-infected children demonstrate various radiographic features, some of which are associated with worse clinical outcomes. To investigate whether specific chest radiological patterns in RSV-infected children with acute respiratory failure (ARF) in the peri-intubation period are associated with prolonged duration of mechanical ventilation. We included RSV-infected children 8 days, a backward stepwise regression arrived at a model that included age and right and left lung atelectasis. Using day 2 chest radiograph results, the best model included age and left lung atelectasis. A model combining the two days' findings yielded an area under the ROC curve of 0.92 with a satisfactory fit (P = 0.95). Chest radiological patterns around the time of intubation can identify children with RSV-associated ARF who would require prolonged mechanical ventilation. (orig.)

  7. Mechanism of Trypanosoma cruzi Placenta Invasion and Infection: The Use of Human Chorionic Villi Explants

    Ricardo E. Fretes

    2012-01-01

    Full Text Available Congenital Chagas disease, a neglected tropical disease, endemic in Latin America, is associated with premature labor and miscarriage. During vertical transmission the parasite Trypanosoma cruzi (T. cruzi crosses the placental barrier. However, the exact mechanism of the placental infection remains unclear. We review the congenital transmission of T. cruzi, particularly the role of possible local placental factors that contribute to the vertical transmission of the parasite. Additionally, we analyze the different methods available for studying the congenital transmission of the parasite. In that context, the ex vivo infection with T. cruzi trypomastigotes of human placental chorionic villi constitutes an excellent tool for studying parasite infection strategies as well as possible local antiparasitic mechanisms.

  8. Mechanism of Anemia in Schistosoma mansoni–Infected School Children in Western Kenya

    Butler, Sara E.; Muok, Erick M.; Montgomery, Susan P.; Odhiambo, Keziah; Mwinzi, Pauline M. N.; Secor, W. Evan; Karanja, Diana M. S.

    2012-01-01

    A better understanding of the mechanism of anemia associated with Schistosoma mansoni infection might provide useful information on how treatment programs are implemented to minimize schistosomiasis-associated morbidity and maximize treatment impact. We used a cross-sectional study with serum samples from 206 Kenyan school children to determine the mechanisms in S. mansoni-associated anemia. Serum ferritin and soluble transferrin receptor levels were measured by using an enzyme-linked immunos...

  9. Prevention and Treatment of Vaginal Bleeding after Drug-induced Abortion by Yaoliuan Capsule and Its Effects on Menses Recovery

    JIN Zhichun; HUANG Guangying

    2005-01-01

    Summary: In order to explore the effect of Yaoliuan capsule in the prevention and treatment of vaginal bleeding after drug-induced abortion and menses recovery after drug-induced abortion, 323 cases of gestation period ≤ 49 days and without contraindication, were divided randomly into study group (168 cases, taking Yaoliuan capsule) and control group (155 cases, taking placebo capsule). The results showed that in the study group, there were 161 cases (95.8 %) of complete abortion, 7 cases (4.2 %) of incomplete abortion; In the control group, there were 146 cases (94.2 %) of complete abortion, 6 cases (3.9 %) of incomplete abortion, 3 cases (1.9 %) of abortion failure. The vaginal bleeding time was 5-25 days (mean 10.8 days) in study group, while that was 6-62 days (mean 19.1 days) in control group. The menstrual cycle was 30.5±5.2 days and 33.8 d±8.6 days respectively in study and control groups. The menstrual period was 6.1±3.5 days and 9.9±5.1 days respectively in study and control groups. Yaoliuan capsule is an effective drug to prevent and treat vaginal bleeding following drug-induced abortion, promote menstruation recovery and prevent pelvic infection.

  10. Abortion in the U.S.: Utilization, Financing, and Access

    Abortion in the U.S.: Utilization, Financing, and Access June 2008 Approximately one-fifth (19%) of the 6. ... occurring annually in the U.S. end in induced abortion. 1 While abortion is one of the most ...

  11. Comparative transcriptome analysis of aerial and subterranean pods development provides insights into seed abortion in peanut

    Wei ZHU; Chen, Xiaoping; Li, Haifen; Zhu, Fanghe; Hong, Yanbin; Rajeev K. Varshney; Liang, Xuanqiang

    2014-01-01

    The peanut is a special plant for its aerial flowering but subterranean fructification. The failure of peg penetration into the soil leads to form aerial pod and finally seed abortion. However, the mechanism of seed abortion during aerial pod development remains obscure. Here, a comparative transcriptome analysis between aerial and subterranean pods at different developmental stages was produced using a customized NimbleGen microarray representing 36,158 unigenes. By comparing 4 consecutive t...

  12. Induced abortion among Brazilian female sex workers: a qualitative study

    Alberto Pereira Madeiro; Debora Diniz

    2015-01-01

    Prostitutes are vulnerable to unplanned pregnancies and abortions. In Brazil, abortion is a crime and there is no data about unsafe abortions for this population. The study describes how prostitutes perform illegal abortions and the health consequences thereof. Semi-structured interviews with 39 prostitutes from three cities in Brazil with previous induced abortion experience were conducted. Sixty-six abortions, with between one and eight occurrences per woman, were recorded. The majority of ...

  13. A Critical Appraisal of Laws on Second Trimester Abortion1

    Berer, Marge

    2013-01-01

    There will always be women who need abortions after 12 weeks of pregnancy, and their reasons are often compelling. Although second trimester abortions carry relatively more risks than first trimester abortions, abortion is still very safe throughout the second trimester if done in safe conditions. This paper is about law and policy on second trimester abortions, which are allowed on more restrictive grounds than first trimester abortions in most countries, if at all. It focuses on countries w...

  14. The role of Neospora caninum and Toxoplasma gondii in spontaneous bovine abortion in Argentina.

    Moore, D P; Regidor-Cerrillo, J; Morrell, E; Poso, M A; Cano, D B; Leunda, M R; Linschinky, L; Odeón, A C; Odriozola, E; Ortega-Mora, L M; Campero, C M

    2008-10-01

    The aim of the present work was to evaluate the role of Neospora caninum and Toxoplasma gondii infections in spontaneous bovine abortions in Argentina. Based on histopathological results, 70 presumptive cases of apicomplexan protozoal abortion from a total of 666 cases of spontaneous bovine abortion submitted to the National Institute of Agrarian Technology, Balcarce, from 1999 to 2007 were included in this study. N. caninum infection was diagnosed by an indirect fluorescent antibody test (IFAT), by immunohistochemistry (IHC) and by nested-PCR. T. gondii infection also was diagnosed by nested-PCR. DNA from fetuses was extracted primarily from CNS tissues. Heart, liver, muscle and/or placenta were processed when nervous tissue was not available. Sixty-six (9.9%) fetuses were positive by at least one technique (IFAT, IHC or nested-PCR) for N. caninum infection. Overall, there was poor agreement among results obtained by these diagnostic techniques. In contrast, no Toxoplasma-infection was detected in any aborted bovine fetus. PMID:18691819

  15. Irish women who seek abortions in England.

    Francome, C

    1992-01-01

    In 1991, 4158 women from Ireland and 1766 from Northern Ireland traveled to England for abortions. This situation has been ignored by Irish authorities. The 1992 case of the 14-year old seeking an abortion in England finally caught legal attention. This study attempts to help define who these abortion seekers are. Questionnaires from 200 Irish abortion seeking women attending private Marie Stopes clinics in London and the British Pregnancy Advisory Services clinic in Liverpool between September 1988 and December 1990 were analyzed. Findings pertain to demographic characteristics, characteristics of first intercourse, family discussion of sexual activity, and contraceptive use. From this limited sample, it appears that Irish women are sexually reserved and without access to modern methods of birth control and abortion. Sex is associated with shame and guilt. 23% had intercourse before the age of 18 years and 42% after the age of 20. 76% were single and 16% were currently married. 95% were Catholic; 33% had been to church the preceding Sunday and 68% within the past month. Basic information about menstruation is also limited and procedures such as dilatation and curettage may be performed selectively. 28% of married women were uninformed about menstruation prior to its onset. Only 24% had been using birth control around the time of pregnancy. The reason for nonuse was frequently the unexpectedness of intercourse. 62% of adults and 66% of women believe in legalizing abortion in Ireland. British groups have tried to break through the abortion information ban by sending telephone numbers of abortion clinics to Irish firms for distribution to employees. On November 25, 1992, in the general election, there was approval of constitutional amendments guaranteeing the right to travel for abortions and to receive information on abortion access. The amendment to allow abortion to save the life of the mother was not accepted. PMID:1483530

  16. J-2X Abort System Development

    Santi, Louis M.; Butas, John P.; Aguilar, Robert B.; Sowers, Thomas S.

    2008-01-01

    The J-2X is an expendable liquid hydrogen (LH2)/liquid oxygen (LOX) gas generator cycle rocket engine that is currently being designed as the primary upper stage propulsion element for the new NASA Ares vehicle family. The J-2X engine will contain abort logic that functions as an integral component of the Ares vehicle abort system. This system is responsible for detecting and responding to conditions indicative of impending Loss of Mission (LOM), Loss of Vehicle (LOV), and/or catastrophic Loss of Crew (LOC) failure events. As an earth orbit ascent phase engine, the J-2X is a high power density propulsion element with non-negligible risk of fast propagation rate failures that can quickly lead to LOM, LOV, and/or LOC events. Aggressive reliability requirements for manned Ares missions and the risk of fast propagating J-2X failures dictate the need for on-engine abort condition monitoring and autonomous response capability as well as traditional abort agents such as the vehicle computer, flight crew, and ground control not located on the engine. This paper describes the baseline J-2X abort subsystem concept of operations, as well as the development process for this subsystem. A strategy that leverages heritage system experience and responds to an evolving engine design as well as J-2X specific test data to support abort system development is described. The utilization of performance and failure simulation models to support abort system sensor selection, failure detectability and discrimination studies, decision threshold definition, and abort system performance verification and validation is outlined. The basis for abort false positive and false negative performance constraints is described. Development challenges associated with information shortfalls in the design cycle, abort condition coverage and response assessment, engine-vehicle interface definition, and abort system performance verification and validation are also discussed.

  17. Association of Histophilus somni with spontaneous abortions in dairy cattle herds from Brazil.

    Headley, Selwyn Arlington; Voltarelli, Daniele; de Oliveira, Victor Henrique Silva; Bronkhorst, Dalton Evert; Alfieri, Alice Fernandes; Filho, Luiz Carlos Negri; Okano, Werner; Alfieri, Amauri Alcindo

    2015-02-01

    This study investigated the participation of infectious agents in spontaneous abortions and reproductive problems at eight dairy cattle herds from three geographical regions of Brazil. Fourteen aborted fetuses and the organ sections of one cow with history of repeated abortions were received for pathological evaluations and molecular diagnostics. PCR/RT-PCR assays targeted specific genes of abortifacient agents of cattle: bovine viral diarrhea virus (BVDV), bovine herpesvirus 1 (BoHV-1), Listeria monocytogenes, Neospora caninum, Leptospira spp., Brucella abortus, and Histophilus somni. Six fetuses were adequate for pathological investigations; one of these did not demonstrate remarkable pathological alterations. Significant histopathological findings included vasculitis, hemorrhage, and fibrinous thrombosis of the cerebrum (n = 4); necrotizing myocarditis (n = 3); and hemorrhagic enteritis (n = 3). The placenta and uterus of the cow as well as the kidney, pancreas, and liver of her aborted fetus contained H. somni DNA and demonstrated histopathological evidence of histophilosis. All fetuses contained H. somni DNA in multiple organs. Coinfections of H. somni with B. abortus (n = 2), N. caninum (n = 2), BVDV (n = 1), and BoHV-1 (n = 1) were identified; two fetuses demonstrated three pathogens. These findings suggest that H. somni was associated with the spontaneous abortions and reproductive problems of these herds. However, the exact cause of fetal death might not be attributed only to H. somni in all aborted fetuses, since some of these were infected with other abortifacient agents. PMID:25480485

  18. Frequency and causes of infectious abortion in a dairy herd in Queretaro, Mexico.

    Escamilla, H Patricia; Martínez, M José Juan; Medina, C Mario; Morales, S Elizabeth

    2007-10-01

    The objective of this study was to determine the frequency of infectious bovine abortion and to identify some of its causes, specifically brucellosis, leptospirosis, bovine viral diarrhea, infectious bovine rhinotracheitis, and neosporosis. The study was carried out in a dairy herd in the state of Queretaro, Mexico, between September 2002 and March 2003. At the beginning of the study, blood samples were taken from a random 33% of the 300 lactating or pregnant cows; antibodies against Leptospira interrogans were the most commonly identified, in 91% of the 99 samples. Blood samples were also taken 14 to 28 d after the 26 subsequent abortions in the herd in the 6-mo study period, as well as from 22 cows that had not aborted within 5 d after the abortions in the other group. Seroconversion was most frequent for L. hardjo, occurring in 8 (67%) of the 12 dams that aborted after the initial serologic sampling and for which paired serum samples were therefore available. Of the 16 collected fetuses, 10 had histologic lesions suggesting infection in various organs, the features correlating with the serologic results for the dams in 7 cases. Thus, the abortions may have been caused by more than 1 infectious agent. PMID:17955907

  19. Induced abortion in China and the advances of post abortion family planning service

    Li Ying; Cheng Yi-ming; Huang Na; Guo Xin; Wang Xian-mi

    2004-01-01

    This is a review of current situation of induced abortion and post abortion family planning service in China. Induced abortion is an important issue in reproductive health. This article reviewed the distribution of induced abortion in various time, areas, and population in China, and explored the character, reason, and harm to reproductive health of induced abortion.Furthermore, this article introduces the concept of Quality of Care Program in Family Planning,and discusses how important and necessary it is to introduce Quality of Care Program in Family Planning to China.

  20. Abortion Legalization and Lifecycle Fertility

    Elizabeth Oltmans Ananat; Jonathan Gruber; Phillip B. Levine

    2004-01-01

    Previous research has convincingly shown that abortion legalization in the early 1970s led to a significant drop in fertility at that time. But this decline may have either represented a delay in births from a point where they were have represented a permanent reduction in fertility. We combine data from the 1970 U.S. Census and microdata from 1968 to 1999 Vital Statistics records to calculate lifetime fertility of women in the 1930s through 1960s birth cohorts. We examine whether those women...

  1. Mechanisms of immunity in post-exposure vaccination against Ebola virus infection.

    Steven B Bradfute

    Full Text Available Ebolaviruses can cause severe hemorrhagic fever that is characterized by rapid viral replication, coagulopathy, inflammation, and high lethality rates. Although there is no clinically proven vaccine or treatment for Ebola virus infection, a virus-like particle (VLP vaccine is effective in mice, guinea pigs, and non-human primates when given pre-infection. In this work, we report that VLPs protect Ebola virus-infected mice when given 24 hours post-infection. Analysis of cytokine expression in serum revealed a decrease in pro-inflammatory cytokine and chemokine levels in mice given VLPs post-exposure compared to infected, untreated mice. Using knockout mice, we show that VLP-mediated post-exposure protection requires perforin, B cells, macrophages, conventional dendritic cells (cDCs, and either CD4+ or CD8+ T cells. Protection was Ebola virus-specific, as marburgvirus VLPs did not protect Ebola virus-infected mice. Increased antibody production in VLP-treated mice correlated with protection, and macrophages were required for this increased production. However, NK cells, IFN-gamma, and TNF-alpha were not required for post-exposure-mediated protection. These data suggest that a non-replicating Ebola virus vaccine can provide post-exposure protection and that the mechanisms of immune protection in this setting require both increased antibody production and generation of cytotoxic T cells.

  2. Usual hospital care versus post-abortion care for women with unsafe abortion: a case control study from Sri Lanka

    Arambepola, Carukshi; Lalini C. Rajapaksa; Galwaduge, Chandani

    2014-01-01

    Background Good quality post-abortion-care (PAC) is essential to prevent death and long-term complications following unsafe abortion, especially in countries with restrictive abortion laws. We assessed the PAC given to women following an unsafe abortion, compared to the routine hospital care following spontaneous abortion or unintended pregnancy carried to term in Sri Lanka. Methods A case–control study was conducted in Sri Lanka among 171 cases following unsafe abortion, 638 controls followi...

  3. Induced Abortion and the Risk of Tubal Infertility

    2008-01-01

    Objective To explore the association between induced abortion and tubal infertility in Chengdu, China.Methods A 1 :2 case-control study was designed. Infertile women with bilateral tubal occlusion in the case group compared with two control groups: infertile control group with bilateral tubal patency and pregnant control group with currently pregnancy. Data were collected using questionnaires through face-to-face interviews, covering the subjects' demographic details and histories of gynecology and obstetrics. Adjusted odds ratio was calculated as a measure of the association using stepwise multiple logistic regression analysis.Results Induced abortion was not found to be associated with tubal infertility in the analysis including either the infertile controls or the pregnant controls, but other risk factors were found, such as history of acute pelvic inflammatory disease (PID), lower abdominal surgeries, dysmenorrhea and pregnancy.Conclusion It is contended that facing an increasing trend of infertile cases with tubal occlusion in China, it is emphasized that special attention should paid to the long term impact of reproductive tract infection, especially, asymptomatic ones, rather than induced abortion.

  4. Complexifying Commodification, Consumption, ART, and Abortion.

    Cohen, I Glenn

    2015-01-01

    This commentary on Madeira's paper complicates the relationships between commodification, consumption, abortion, and assisted reproductive technologies (ARTs) she draws in two ways. First, I examine under what conditions the commodification of ARTs, gametes, and surrogacy lead to patients becoming consumers. Second, I show that there are some stark difference between applying commodification critiques to ART versus abortion. PMID:26242952

  5. Provokeret abort og stratificeret reproduktion i Danmark

    Gammeltoft, Tine; Rasch, Vibeke; Knudsen, Lisbeth B.

    2007-01-01

    Hvorfor får kvinder med indvandrerbaggrund dobbelt så mange provokerede aborter som andre kvinder i Danmark? Det var udgangsspørgsmålet for det forskningsprojekt, denne artikel er baseret på. Artiklens argument er, at når nogle grupper af minoritetskvinder får flere aborter end andre kvinder i...

  6. Induced Abortion: An Ethical Conundrum for Counselors.

    Millner, Vaughn S.; Hanks, Robert B.

    2002-01-01

    Induced abortion is one of the most controversial moral issues in American culture, but counselor value struggles regarding abortion are seldom addressed in counseling literature. This article considers the conflictual nature of the ethical principles of autonomy, fidelity, justice, beneficence, and nonmaleficence as they can occur within the…

  7. Provokeret abort og stratificeret reproduktion i Danmark

    Gammeltoft, Tine; Rasch, Vibeke; Knudsen, Lisbeth B.

    Hvorfor får kvinder med indvandrerbaggrund dobbelt så mange provokerede aborter som andre kvinder i Danmark? Det var udgangsspørgsmålet for det forskningsprojekt, denne artikel er baseret på. Artiklens argument er, at når nogle grupper af minoritetskvinder får flere aborter end andre kvinder i...

  8. [Scope of the indications for abortion].

    Martella, E

    1976-09-01

    Legalization of abortion in Italy generates never ending discussions. The problem should have been solved years ago with a national campaign for family planning, with the setting up of well organized family centers, and with contraception available and free to all. If it seems right and proper to perform abortion under certain circumstances, it does not seem proper to take into consideration socioeconomic conditions, and certainly not abortion on request; a new life must not be wasted because a woman does not feel like having a new child. Abortion, on the other hand, is certainly to be considered in case of danger for the mother, in case of fetal abnormalities, or when the pregnancy is result of incest or of rape. Abortion for psychological reasons is very valid if the reasons are real, evident, and have been thoroughly evaluated. PMID:1012595

  9. Ultrasonographic findings of early abortion: suggested predictors

    To investigate predictable ultrasonographic findings of early abortion. To investigate objective rules for the screening of abortion. Ultrasonographic examination of 111 early pregnancies between the sixth and ninth week in women who had regular 28 day menstrual cycles was performed. Ultrasonographic measurements of the gestational sac, crown rump length and fetal heart rate were performed using a linear array real time transducer with doppler ultrasonogram. All measurements of 17 early abortions were compared to those of 94 normal pregnancies. Most of early aborted pregnancies were classified correctly by discriminant analysis with G-SAC and CRL (G-SAC=0.5 CRL + 15, sensitivity 76.5%, specificity 96.8%). With the addition of FHR, 94.1% of early abortions could be predicted. In conclusion, ultrasonographic findings of early intrauterine growth retardation, small gestational sac and bradycardia can be predictable signs suggestive of poor prognosis of early pregnancies

  10. [Therapeutic abortion, unjustified absence in health policy].

    Chávez-Alvarado, Susana

    2013-07-01

    Although abortion for health reasons is not considered a crime in Peru, the State does not allow its inclusion in public policy, thus violating women's right to terminate a pregnancy when it affects their health. When examining the article in the Criminal Code which decriminalizes this type of abortion, provisions are identified which protect women and set the conditions to offer this type of service. This document sets the debate about the arguments used by the Peruvian State for not approving a therapeutic abortion protocol which would regulate the provision and financing of therapeutic abortion in public services, and explains why this obligation should be complied with, based on the conceptual framework of "health exception" In addition, it presents two cases brought before the judicial court in which the Peruvian State was found guilty of violating the human rights of two adolescents to whom a therapeutic abortion was denied. PMID:24100828

  11. Ultrasonographic findings of early abortion: suggested predictors

    Jun, Soon Ae; Ahn, Myoung Ock; Cha, Kwang Yul [Cha Women' s Hospital of Seoul, Seoul (Korea, Republic of); Lee, Young Doo [Yonsei University Medical College, Seoul (Korea, Republic of)

    1992-05-15

    To investigate predictable ultrasonographic findings of early abortion. To investigate objective rules for the screening of abortion. Ultrasonographic examination of 111 early pregnancies between the sixth and ninth week in women who had regular 28 day menstrual cycles was performed. Ultrasonographic measurements of the gestational sac, crown rump length and fetal heart rate were performed using a linear array real time transducer with doppler ultrasonogram. All measurements of 17 early abortions were compared to those of 94 normal pregnancies. Most of early aborted pregnancies were classified correctly by discriminant analysis with G-SAC and CRL (G-SAC=0.5 CRL + 15, sensitivity 76.5%, specificity 96.8%). With the addition of FHR, 94.1% of early abortions could be predicted. In conclusion, ultrasonographic findings of early intrauterine growth retardation, small gestational sac and bradycardia can be predictable signs suggestive of poor prognosis of early pregnancies.

  12. Effects of ovule and seed abortion on brood size and fruit costs in the leguminous shrub Caesalpinia gilliesii (Wall. ex Hook. D. Dietr

    Ana Calviño

    2014-03-01

    Full Text Available For several plant species, brood size results from the abortion of ovules and seeds. However, these processes have rarely been studied together in wild plants. In some of the leguminous species studied, seed abortion has been found to depend on pollen quality and on the position of the ovule or fruit. The direct consequence for the mother plant is that fruit costs increase as the seed:ovule ratio decreases. However, because ovule abortion occurs earlier than does seed abortion, the former can reduce the biomass invested per seed (i.e., fruit costs more efficiently than does the latter. Here, the frequencies of aborted ovules and seeds were analyzed in relation to the type of pollination treatment (open pollination vs. hand cross-pollination and ovule/fruit position within pods of the leguminous shrub Caesalpinia gilliesii. The influence of ovule and seed abortion on fruit costs was analyzed by comparing the pericarp mass per seed between fruits with different frequencies of aborted ovules and seeds. The rate of ovule abortion was similar between hand cross-pollinated and open-pollinated fruits but was higher than that of seed abortion in one- and two-seeded fruits, as well as in those at stylar positions and in distal fruits. Hand cross-pollination reduced seed abortion but did not increase the seed:ovule ratio. In addition, fruits that aborted ovules were found to be less costly than were those that aborted seeds. From the mother plant perspective, these results indicate that ovule abortion is a more efficient mechanism of reducing fruit costs than is seed abortion, because fertilization opportunities decrease with position, and show that brood size is significantly influenced by the fate of the ovule at the pre-zygotic stage.

  13. Medical abortion: the hidden revolution.

    Harvey, Phil

    2015-07-01

    While the medical abortion (MA) drugs, mifepristone and misoprostol, have radically altered reproductive health practices around the world, there has been little field research on the sales and use of these drugs, especially in developing countries. This leaves the family planning community with many unanswered questions. While good profiles of contraceptive use are available for many countries and we have good technical data on the MA drugs' efficacy, dosages and regimens such as home dosage of misoprostol versus clinic dosage, we have very little information about the quantities of MA drugs sold, how they are used, where they are used, and, in the case of misoprostol, for what purposes. Sales data are available from one excellent commercial survey and from social marketing sales of mifepristone and misoprostol and these are presented. Acknowledging the sensitivity of the issue, especially in countries where abortion is severely restricted, the author makes a plea for careful additional research to shed light on an important and growing part of the international reproductive health picture. PMID:26106105

  14. Action mechanisms of lithium chloride on cell infection by transmissible gastroenteritis coronavirus.

    Xiaofeng Ren

    Full Text Available Transmissible gastroenteritis virus (TGEV is a porcine coronavirus. Lithium chloride (LiCl has been found to be effective against several DNA viruses, such as Herpes simplex virus and vaccinia virus. Recently, we and others have reported the inhibitory effect of LiCl on avian infectious bronchitis coronavirus (IBV infection, an RNA virus. In the current study, the action mechanism of LiCl on cell infection by TGEV was investigated. Plaque assays and 3-(4,5-dimethylthiahiazo(-z-y1-3,5-di-phenyl tetrazoliumbromide (MTT assays showed that the cell infection by TGEV was inhibited in a dose-dependent manner, when LiCl was added to virus-infected cells; the cell infection was not affected when either cells or viruses were pretreated with the drug. The inhibition of TGEV infection in vitro by LiCl was observed at different virus doses and with different cell lines. The inhibitory effect of LiCl against TGEV infection and transcription was confirmed by RT-PCR and real-time PCR targeting viral S and 3CL-protease genes. The time-of-addition effect of the drug on TGEV infection indicated that LiCl acted on the initial and late stage of TGEV infection. The production of virus was not detected at 36 h post-infection due to the drug treatment. Moreover, immunofluorescence (IF and flow cytometry analyses based on staining of Annexin V and propidium iodide staining of nuclei indicated that early and late cell apoptosis induced by TGEV was inhibited efficiently. The ability of LiCl to inhibit apoptosis was investigated by IF analysis of caspase-3 expression. Our data indicate that LiCl inhibits TGEV infection by exerting an anti-apoptotic effect. The inhibitory effect of LiCl was also observed with porcine epidemic diarrhea coronavirus. Together with other reports concerning the inhibitory effect of lithium salts on IBV in cell culture, our results indicate that LiCl may be a potent agent against porcine and avian coronaviruses.

  15. Abortive lytic Epstein–Barr virus replication in tonsil-B lymphocytes in infectious mononucleosis and a subset of the chronic fatigue syndrome

    Lerner AM

    2012-11-01

    . Abortive lytic replication may be a pathogenic mechanism for EBV disease. EBV (HHV4 is a gamma herpesvirus composed of dsDNA about 170 Kb in length. For this discussion, there are early genes (including expressions of encoded proteins EBV dUTPase, DNA polymerase, and nuclear proteins and late genes (including expressions of capsid and membrane proteins. Abortive infection infers incomplete virion expressions of either early or late proteins, but the virion is incomplete. The lytic virus infers a complete virion. The pathologic consequences of EBV abortive replication are currently being investigated by authors.Keywords: Epstein–Barr virus, chronic fatigue syndrome, subset chronic fatigue syndrome, abortive lytic replication

  16. Labour Force Participation and the Likelihood of Abortion in Finland over Three Birth Cohorts

    Väisänen, Heini

    2015-12-01

    Full Text Available There is a lack of studies on the association between labour force participation and abortion. This study examined how the likelihood of having an abortion depends on being employed, unemployed, student or outside the workforce using Finnish register data from three birth cohorts (born in 1955-59, 1965-69 and 1975-79 of nearly 260,000 women. The results differed depending on whether all women or only pregnant women were studied and on the cohort analysed. Unemployed women had a high likelihood of abortion when all women were studied, but among pregnant women students had the highest likelihood. The direction and strength of the association varied by relationship status, age, and parity. The results show that the likelihood of abortion depends on women’s economic position. More studies on contraceptive use and pregnancy intentions in Finland are needed to identify the mechanisms behind these findings.

  17. Reproductive rights: Current issues of late abortion

    Mujović-Zornić Hajrija

    2009-01-01

    Full Text Available This article considers the legal issues surrounding induced late abortion in cases when severe medical, therapeutic or ethical reasons have not been in dispute. Generally discussing the essential question about abortion today, it means not anymore legality of abortion but, in the first place, safety of abortion. From the aspect of woman health the most important aim is to detect and avoid possible risks of medical intervention, such as late abortion present. This is the matter of medical law context and also the matter of the woman's reproductive rights, here observed through legislation and court practice. The gynecologist has an obligation to obtain the informed consent of each patient. Information's should be presented in reasonably understandable terms and include alternative modes of treatment, objectives, risks, benefits, possible complications, and anticipated results of such treatment. Pregnant woman should receive supportive counseling before and particularly after the procedure. The method chosen for all terminations should ensure that the fetus is born dead. This should be undertaken by an appropriately trained practitioner. Reform in abortion law, making it legally accessible to woman, is not necessarily the product of a belief in woman's rights, but can be a means of bringing the practice of abortion back under better control. Counseling and good medical practice in performing late abortion are the instruments to drive this point even further home. It does not undermine the woman who wants to make a positive decision about her life and its purpose is not to produce feelings of insecurity and guilt. It concludes that existing law should not be changed but that clear rules should be devised and board created to review late term abortion. In Serbia, this leads to creation and set up guidelines for reconciling medical justification for late abortion with existing law, especially with solutions which brings comparative law. .

  18. [Induced abortion: a vulnerable public health problem].

    Requena, M

    1991-03-01

    Induced abortion is an urgent public health problem that can be controlled if it is approached in its true complexity and with a social and humanist perspective. Induced abortion has been discussed in Chile since the last century, but not always openly. Abortion is not just an individual and collective medical problem, it is also an ethical, religious, legal, demographic, political, and psychological problem. Above all it is a problem of human rights. In the past 60 years, more than 50 countries representing 76% of the world population have liberalized their abortion legislation. Around 980 million women have some degrees of access of legal abortion. The magnitude of illegal abortion is difficult to determine because of the desire of women to hide their experiences. Estimates of the incidence of abortion in Chile made some 25 years ago are no longer valid because of the numerous social changes in the intervening years. The number of abortions in Chile in 1987 was estimated using an indirect residual method at 195,441, of which 90%, or 175,897, were induced. By this estimate, 38.8% of pregnancies in Chile end in abortion. Data on hospitalizations for complications of induced abortion show an increase from 13.9/1000 fertile aged women in 1940 to 29.1 in 1965. By 1987, with increased contraceptive usage, the rate declined to 10.5 abortions per 1000 fertile aged women. The cost of hospitalization for abortion complications in 1987, despite the decline, was still estimated at US $4.3 million, a large sum in an era of declining health resources. The problem of induced abortion can be analyzed by placing it in the context of elements affecting the desire to control fertility. 4 complexes of variables are involved: those affecting the supply of contraceptive, the demand for contraceptives, the various costs of fertility control measure, and alternatives to fertility control for satisfying various needs. The analysis is further complicated when efforts are made to

  19. A Swiss case-control study to assess Neospora caninum-associated bovine abortions by PCR, histopathology and serology.

    Sager, H; Fischer, I; Furrer, K; Strasser, M; Waldvogel, A; Boerlin, P; Audigé, L; Gottstein, B

    2001-12-01

    Neospora caninum is one of the most frequent infectious organisms causing abortion in cattle worldwide. The present case-control study was designed to assess the importance of bovine neosporosis for causing abortion in Swiss cattle and to identify selected risk factors. Infection was primarily diagnosed by a N. caninum-specific PCR and serology, complemented with histopathology and immunohistochemistry. A total of 113 case and 113 corresponding control-farms were studied for 1.5 year. During this time period, 242 abortions were reported and referred for bacteriological, virological, parasitological and pathohistological examinations. N. caninum was detected by PCR in the brains of 21% of all aborted fetuses. Microscopic lesions indicative for cerebral protozoa infection were detected in 84% of PCR-positive fetal brains. Bovine viral diarrhea virus (BVDV) was demonstrated in 7% of the cases, and bacterial infections were detected in 4% of the abortions. One or more N. caninum-abortions occurred in 20% of the herds (41 case-farms and 3 control-farms). Serological examination of aborting mother cows revealed a significantly higher percentage of N. caninum-seropositive animals (44%) in comparison to the prevalence in a randomly selected population (12%). However, in eight cases (4% of all investigated abortions) seronegative cows aborted N. caninum PCR-positive fetuses, and in 50 cases the fetus remained negative although the respective mother cow was N. caninum-seropositive. Repetitive serological investigations (at a 3-12 months interval) of 3551 cows from case- and control-farms showed a decrease of the overall N. caninum-seroprevalence from 17 to 12%. Ninety out of 3008 seronegative animals were converted to N. caninum-seropositivity. Conversely, 212 out of 543 initially seropositive animals became seronegative for their second serum sample. The obtained data underlined the importance of N. caninum as a causative agent for abortion in Swiss cattle. Furthermore, PCR

  20. Transcriptome analysis and gene expression profiling of abortive and developing ovules during fruit development in hazelnut.

    Yunqing Cheng

    Full Text Available A high ratio of blank fruit in hazelnut (Corylus heterophylla Fisch is a very common phenomenon that causes serious yield losses in northeast China. The development of blank fruit in the Corylus genus is known to be associated with embryo abortion. However, little is known about the molecular mechanisms responsible for embryo abortion during the nut development stage. Genomic information for C. heterophylla Fisch is not available; therefore, data related to transcriptome and gene expression profiling of developing and abortive ovules are needed.In this study, de novo transcriptome sequencing and RNA-seq analysis were conducted using short-read sequencing technology (Illumina HiSeq 2000. The results of the transcriptome assembly analysis revealed genetic information that was associated with the fruit development stage. Two digital gene expression libraries were constructed, one for a full (normally developing ovule and one for an empty (abortive ovule. Transcriptome sequencing and assembly results revealed 55,353 unigenes, including 18,751 clusters and 36,602 singletons. These results were annotated using the public databases NR, NT, Swiss-Prot, KEGG, COG, and GO. Using digital gene expression profiling, gene expression differences in developing and abortive ovules were identified. A total of 1,637 and 715 unigenes were significantly upregulated and downregulated, respectively, in abortive ovules, compared with developing ovules. Quantitative real-time polymerase chain reaction analysis was used in order to verify the differential expression of some genes.The transcriptome and digital gene expression profiling data of normally developing and abortive ovules in hazelnut provide exhaustive information that will improve our understanding of the molecular mechanisms of abortive ovule formation in hazelnut.

  1. Surgical infections with Mycoplasma

    Levi-Mazloum, Niels Donald; Prag, Jørgen Brorson; Jensen, J S;

    1997-01-01

    Mycoplasma hominis and Ureaplasma urealyticum are common inhabitants of the human genital tract. Evidence for an aetiological role in pyelonephritis, pelvic inflammatory disease, post-abortion and post-partum fever has been presented. There are sporadic reports of Mycoplasma causing serious...... extragenital infection such as septicemia, septic arthritis, neonatal meningitis and encephalitis. We review 38 cases of surgical infections with Mycoplasma....

  2. Mechanisms linking bacterial infections of the bovine endometrium to disease and infertility.

    Carneiro, Luísa Cunha; Cronin, James Graham; Sheldon, Iain Martin

    2016-03-01

    Bacterial infections of the endometrium after parturition commonly cause metritis and endometritis in dairy cattle, and these diseases are important because they compromise animal welfare and incur economic costs, as well as delaying or preventing conception. Here we highlight that uterine infections cause infertility, discuss which bacteria cause uterine disease, and review the evidence for mechanisms of inflammation and tissue damage in the endometrium. Bacteria cultured from the uterus of diseased animals include Escherichia coli, Trueperella pyogenes, and several anaerobic species, but their causative role in disease is challenged by the discovery of many other bacteria in the uterine disease microbiome. Irrespective of the species of bacteria, endometrial cell inflammatory responses to infection initially depend on innate immunity, with Toll-like receptors binding pathogen-associated molecular patterns, such as lipopolysaccharide and bacterial lipopeptides. In addition to tissue damage associated with parturition and inflammation, endometrial cell death is caused by a cholesterol-dependent cytolysin secreted by T. pyogenes, called pyolysin, which forms pores in plasma membranes of endometrial cells. However, endometrial cells surprisingly do not sense damage-associated molecular patterns, but a combination of infections followed by cell damage leads to release of the intracellular cytokine interleukin (IL)-1 alpha from endometrial cells, which then acts to scale inflammatory responses. To develop strategies to limit the impact of uterine disease on fertility, future work should focus on determining which bacteria and virulence factors cause endometritis, and understanding how the host response to infection is regulated in the endometrium. PMID:26952747

  3. [Up-to-date findings in the host defence mechanism to cryptococcus infection].

    Ishii, Keiko; Kawakami, Kazuyoshi

    2014-01-01

    Cryptococcus neoformans is a medically important opportunistic fungal pathogen with a polysaccharide capsule surrounding the yeast-like cells. In hosts with impaired cell-mediated immunity such as AIDS, uncontrolled infection causes life-threatening meningoencephalitis. In immunocompetent individuals, the host immune response usually limits the growth of the fungal pathogen at the primary infected site, where it may persist, without completely eradicated, in a latent state because of its ability to escape from killing by macrophages. Th1 response in adaptive immunity is essential for the host defense to cryptococcal infection, in which interferon (IFN)-γ polarizes innate macrophages into fungicidal M1 macrophages. Recently, we found that caspase recruitment domain family member (CARD9), an adaptor protein in a signal transduction triggered by C-type lectin receptors, plays a key role in the early production of IFN-γ at the site of infection by recruiting NK cells and CD4(+) and CD8(+) memory-phenotype T cells. We also found that IL-4 produced by Th2 cells stimulates broncoepithelial cells to secrete mucin, which may lead to promotion in the mucociliary clearance of C. neoformans. Here, we summarize the up-to-date findings in the host defense mechanism to this infection with focusing on our recent data. PMID:25231225

  4. Mechanics governs single-cell signaling and multi-cell robustness in biofilm infections

    Gordon, Vernita

    In biofilms, bacteria and other microbes are embedded in extracellular polymers (EPS). Multiple types of EPS can be produced by a single bacterial strain - the reasons for this redundancy are not well-understood. Our work suggests that different polymers may confer distinct mechanical benefits. Our model organism is Pseudomonas aeruginosa, an opportunistic human pathogen that forms chronic biofilm infections associated with increased antibiotic resistance and evasion of the immune defense. Biofilms initiate when bacteria attach to a surface, sense the surface, and change their gene expression. Changes in gene expression are regulated by a chemical signal, cyclic-di-GMP. We find that one EPS material, called ``PEL,'' enhances surface sensing by increasing mechanical coupling of single bacteria to the surface. Measurements of bacterial motility suggest that PEL may increase frictional interactions between the surface and the bacteria. Consistent with this, we show that bacteria increase cyclic-di-GMP signaling in response to mechanical shear stress. Mechanosensing has long been known to be important to the function of cells in higher eukaryotes, but this is one of only a handful of studies showing that bacteria can sense and respond to mechanical forces. For the mature biofilm, the embedding polymer matrix can protect bacteria both chemically and mechanically. P. aeruginosa infections in the cystic fibrosis (CF) lung often last for decades, ample time for the infecting strain(s) to evolve. Production of another EPS material, alginate, is well-known to tend to increase over time in CF infections. Alginate chemically protects biofilms, but also makes them softer and weaker. Recently, it is being increasingly recognized that bacteria in chronic CF infections also evolve to increase PSL production. We use oscillatory bulk rheology to determine the unique contributions of EPS materials to biofilm mechanics. Unlike alginate, increased PSL stiffens biofilms. Increasing both

  5. HLA-G polymorphisms in couples with recurrent spontaneous abortions

    Hviid, T V; Hylenius, S; Hoegh, A M;

    2002-01-01

    The etiology of a fraction of recurrent spontaneous abortions (RSA) may involve immunological mechanisms. Aberrant profiles of Th1 and Th2 cytokines have been observed which are not present in uncomplicated pregnancies. Studies of classical HLA class I and II antigens in relation to RSA have not...... been conclusive. Furthermore, these antigens are not expressed in the placenta with the exception of HLA-C. However, HLA-G is expressed on especially invasive cytotrophoblasts and exists in both membrane and soluble forms. HLA-G may be involved in materno-fetal tolerance. Therefore, 61 RSA couples...... (with three or more spontaneous abortions) and 47 fertile control couples were HLA-G genotyped by direct DNA sequencing and analyzed for specific polymorphisms. No statistically significant differences were observed in the distribution of HLA-G alleles between controls and RSA couples, however, 15% of...

  6. Chicken pox infection (varicella zoster virus) and acute monoarthritis: evidence against a direct viral mechanism.

    Fink, C G; Read, S J; Giddins, G.; Eglin, R. P.

    1992-01-01

    A 9 year old boy developed acute monoarthritis of the left knee concurrent with the appearance of a varicella zoster virus (VZV) rash. Repeated VZV DNA hybridisation of the cells within the synovial fluid and synovial membrane failed to show any evidence of intracellular virus. Virus was isolated from synovial fluid 24 hours after the start of clinical infection but not later. These findings suggest that the mechanism of the arthritis is not due to viral replication inside the swollen joint.

  7. Current views on the mechanisms of immune responses to trauma and infection

    Binkowska, Aneta Małgorzata; Michalak, Grzegorz; Słotwiński, Robert

    2015-01-01

    According to the World Health Organization, post-traumatic mortality rates are still very high and show an increasing tendency. Disorders of innate immune response that may increase the risk of serious complications play a key role in the immunological system response to trauma and infection. The mechanism of these disorders is multifactorial and is still poorly understood. The changing concepts of systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response synd...

  8. A novel mechanism inducing genome instability in Kaposi's sarcoma-associated herpesvirus infected cells.

    Jackson, Brian R.; Marko Noerenberg; Adrian Whitehouse

    2014-01-01

    Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic herpesvirus associated with multiple AIDS-related malignancies. Like other herpesviruses, KSHV has a biphasic life cycle and both the lytic and latent phases are required for tumorigenesis. Evidence suggests that KSHV lytic replication can cause genome instability in KSHV-infected cells, although no mechanism has thus far been described. A surprising link has recently been suggested between mRNA export, genome instability and canc...

  9. Evolutionary Mechanisms of Persistence and Diversification of a Calicivirus within Endemically Infected Natural Host Populations▿

    Coyne, Karen P.; Gaskell, Rosalind M.; Dawson, Susan; Porter, Carol J.; Radford, Alan D

    2006-01-01

    In order to understand the evolutionary mechanisms of persistence and diversification within the Caliciviridae, we have been exploiting endemic infection of feline calicivirus within five geographically distinct household groups of cats. By sequencing immunodominant and variable regions of the capsid gene, we identified the relative contribution of the different evolutionary processes employed by the virus to ensure its long-term survival in the host population. Such strategies included progr...

  10. Ireland: child rape case undermines abortion ban.

    1992-11-01

    Abortion has been illegal in Ireland since 1861. This position was written into the national Constitution in 1963 and reconfirmed by referendum in 1983. Contraception is also illegal in the country. The pregnancy of a 14-year old adolescent due to an alleged rape, however, has caused many in Ireland to voice their support for abortion in limited circumstances. Approximately 5000 pregnant women go from Ireland to the United Kingdom annually for abortions. This 14-year old youth also planned to make the crossing, but was blocked from leaving by the Irish police and later by an injunction of the Attorney-General. The Irish Supreme Court upheld the injunction even though the young woman was reportedly contemplating suicide. A national outcry ensued with thousands of demonstrators marching in Dublin to demand the availability of information on abortion and that Irish women be allowed to travel whenever and wherever they desire. 66% of respondents to recent public opinion polls favor abortion in certain circumstances. Ultimately, the Irish Supreme Court reversed their stance to allow pregnant Irish women to travel internationally and gave suicidal Irish women the right to abortions. These decisions were made shortly within the time frame needed for the young lady in question to received a legal abortion in the United Kingdom. PMID:12222235

  11. 21 CFR 884.5050 - Metreurynter-balloon abortion system.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Metreurynter-balloon abortion system. 884.5050... Devices § 884.5050 Metreurynter-balloon abortion system. (a) Identification. A metreurynter-balloon abortion system is a device used to induce abortion. The device is inserted into the uterine...

  12. The Impact of State Abortion Policies on Teen Pregnancy Rates

    Medoff, Marshall

    2010-01-01

    The availability of abortion provides insurance against unwanted pregnancies since abortion is the only birth control method which allows women to avoid an unwanted birth once they are pregnant. Restrictive state abortion policies, which increase the cost of obtaining an abortion, may increase women's incentive to alter their pregnancy avoidance…

  13. SOCIO-DEMOGRAPHIC PROFILES OF SEPTIC ABORTION

    Manoj

    2014-05-01

    Full Text Available INTRODUCTION: Septic abortion is a significant contributor to maternal morbidity and mortality. Termination of pregnancy, although a safe and easy procedure in trained hands, can produce catastrophic outcomes when performed by unauthorized or untrained people and in improper settings. OBJECTIVE: To find out the association of various socio-demographic factors with septic abortion. MATERIAL AND METHODS: This was a longitudinal study, conducted in the indoor of obstetrics & gynaecology department of R.M.C.H & R.C, Ghaziabad district of Uttar Pradesh from the period of Feb-2013 to April-2013, after selecting 100 septic abortion cases by simple randomization, who were admitted during the study period. Information of all these cases regarding their age, marital status, socio-economic status, literacy, parity and gestational age was obtained, and their association with septic abortion was studied accordingly. OBSERVATION: Out of the 100 cases of septic abortion studied, maximum percentage (66% of the cases was seen from the age group of 26 to 35 years. Most of the cases (97% were married, maximum (40% were belonging from low socio-economic status group (Group-IV, maximum (60% number of cases were illiterate, maximum (53% number of cases belonged to women group having parity five and above, and maximum (86% number of women were in the 1st trimester of pregnancy at the time of abortion. CONCLUSION: Present study confirms that unsafe abortion is one of the greatest neglected healthcare problems in India and more so in rural India. So, there is the need to strengthen quality abortion services to reduce the maternal morbidity and mortality due to septic abortion

  14. The abortion debate: measuring gestational age.

    Santee, B; Henshaw, S K

    1992-01-01

    Abortion statistics are flawed by the lack of consistency in reporting gestational age. Several methods are generally used, and the number of abortions occurring before 12 weeks changes considerably depending upon the method used to determine gestational age. Pregnancy can be measured from the beginning of last menstruation or from fertilization, which is 14 days after the 1st day of the last menstrual period. Neither method accurately records pregnancy as determined by specialists in embryology and fetal development. Pregnancy actually begins with implantation, which begins 6-7 days after fertilization and ends 10-14 days later. Completion of fertilization and implantation occurs as much as 28 days after the 1st day of the last menstrual period. A report of an 8-week pregnancy is actually 6 weeks from fertilization and 4-5 weeks from implantation. The Centers for Disease Control and other abortion data collecting agencies use the 1st day of the last menstrual period. Statistics generally show that 50% of abortions occur before 8 weeks of gestation and 90% by 12 weeks. When gestation is considered at fertilization, 78% of abortions occur under 9 weeks, while 52% of abortions under 9 weeks are performed with data beginning at the 1st day of the last menstrual period. For abortions occurring under 12 weeks, 95% beginning at fertilization and 90% occur at the 1st day of the last menstrual period. 2/1000 vs. 5/1000 abortions occur under 20 weeks for data beginning at fertilization vs. at the onset of the last period. It is important to report abortion data accurately and to specify the method used to determine the gestational time period. PMID:1526273

  15. CONSULTANT REPORT INCOMPLETE ABORTIONS TREATED AT JAHANSHAH SALEH HOSPITAL IN TEHRAN, IRAN FROM MAY 14, 1973

    Yahya Behjatnia

    1978-01-01

    Full Text Available In the period from May, 1973 to April, 1974, one hundred patients were trea ted for incomple te abortion at the ]ahanshah Saleh Hospital in Tehran, Iran. Patients admitted to th e hospital were from 4 to 28 weeks' gestation and were routinely administered analgestics before the abortion was completed by D&C. The D&C took about 10 minutes and the patient was usually able to go home that same day: Twenty-four women (24 .0% experienced complicatio n(s including blood loss, fever requiring antibiotic treatment, and pelvic infection.

  16. How technology is reframing the abortion debate.

    Callahan, D

    1986-02-01

    Since the 1973 Supreme Court decision legalizing abortion, medical and scientific developments have focused greater public and professional attention on the status of the fetus. Their cumulative effect may influence legal, social, and moral thought and set the stage for a change in public opinion and a challenge to legalized abortion. There is as yet no inexorable convergence of medical data and legal opinion that would undermine the rational of Roe v. Wade. But the prochoice movement must find room for an open airing of the moral questions if abortion is to remain what it should be--a legally acceptable act. PMID:3514547

  17. economics of abortion and children in care

    Bagaria, Manish

    2007-01-01

    This paper investigates the relationship between abortion and children in care. Data from 1967 to 1973 are used to test the hypothesis, whether or not legalisation of abortion in England had some effect on the number children in care. The motivation of this research comes from the negative association between abortion rates and reported crime found by Donohue and Levitt (2001) for the U.S. and replication of the same in the U.K in Kahane's, Paton's and Simmons research (2007). Although childr...

  18. Aborto. Responsabilidad compartida/Abortion. Shared responsibility

    David Ernesto Betancourt

    2010-08-01

    Full Text Available The father and the mother are involved in the act of procreation, therefore in abortion should also be considered is the father figure in some way and not let you load psychological, emotional and physical exclusively women. Similarly, when she decides to have an abortion he is not observed or questioned integral form to family and society to which she belongs, in short, the stigmatization affects only to the woman in question when there are several actors and circumstances that come into the Act of abortion.

  19. Survey of nine abortifacient infectious agents in aborted bovine fetuses from dairy farms in Beijing, China, by PCR.

    Yang, Na; Cui, Xia; Qian, Weifeng; Yu, Shanshan; Liu, Qun

    2012-03-01

    Abortion in dairy cattle causes considerable economic losses to the dairy industry. Aborted fetuses and samples from the corresponding aborting dams from 12 dairy herds in Beijing were tested for 9 abortifacient infectious pathogens by PCR between 2008 and 2010. From a total of 80 abortion cases collected during this period, infectious agents were detected in 45 (56.3%) cases, 22 (48.9%) of which represented co-infections with two or three infectious agents. The detected pathogens included infectious bovine rhinotracheitis virus (36.3%) and Neospora caninum (31.3%), followed by bovine viral diarrhoea virus (7.5%), Brucella abortus (6.3%), Tritrichomonas foetus (5%) and Toxoplasma gondii (1.3%). Campylobacter fetus, Coxiella burnetii and Chlamydophila psittaci were not detected in any abortion case. Findings from this study indicated that infectious bovine rhinotracheitis virus and Neospora caninum were the main potential causes of abortions in Beijing dairy herds, whereas the bacterial pathogens were not, in contrast to reports from other countries. This is the first study to test nine abortifacient infectious agents by PCR at the same time, and it is also the first time to report the involvement of a variety of infectious agents in bovine abortion cases in China. PMID:22366134

  20. Public opinion about abortion-related stigma among Mexican Catholics and implications for unsafe abortion.

    McMurtrie, Stephanie M; García, Sandra G; Wilson, Kate S; Diaz-Olavarrieta, Claudia; Fawcett, Gillian M

    2012-09-01

    A nationally representative survey was conducted among 3000 Catholics in Mexico during 2009 and 2010. Respondents were presented with a hypothetical situation about a young woman who decided to have an abortion and were asked their personal opinion of her. On the basis of a stigma index, it was found that the majority (61%) had stigmatizing attitudes about abortion; however, 81% believed that abortion should be legal in at least some circumstances. Respondents were significantly more likely to stigmatize abortion if they disagreed with the Mexico City law legalizing the procedure (odds ratio 1.66; 95% CI, 1.30-2.11) and believed that abortion should be prohibited in all cases (odds ratio 3.13; 95% CI, 2.28-4.30). Such stigma can lead women to seek unsafe abortions to avoid judgment by society. PMID:22920621

  1. Psychology Consequences of Abortion Among The Post Abortion Care Seeking Women in Tehran

    Abolghasem Pourreza; Aziz Batebi

    2011-01-01

    "nObjective: abortion either medical or criminal has distinctive physical, social, and psychological side effects. Detecting types and frequent psychological side effects of abortion among post abortion care seeking women in Tehran was the main objective of the present study. "n Method: 278 women of reproductive age (15-49) interviewed as study population. Response rate was 93/8. Data collected through a questionnaire with 2 parts meeting broad socio-economic characteristics of the respo...

  2. Psychological Consequences of Abortion among the Post Abortion Care Seeking Women in Tehran

    Pourreza, Abolghasem; Batebi, Aziz

    2011-01-01

    Objective Abortion either medical or criminal has distinctive physical, social, and psychological side effects. Detecting types and frequent psychological side effects of abortion among post abortion care seeking women in Tehran was the main objective of the present study. Method 278 women of reproductive age (15-49) interviewed as study population. Response rate was 93/8. Data collected through a questionnaire with 2 parts meeting broad socio-economic characteristics of the respondents and h...

  3. Therapeutic abortion in Siriraj Hospital: A 10-year review

    Chanon Neungton; Saifon Chawanpaiboon

    2013-01-01

    Objective: To assess indications, methods of interventions and gestational age of women underwent therapeutic abortion. Method: A total of 1381 cases of pregnant women underwent therapeutic abortion with completed charts between 1st January, 2001 to 31st December, 2010, were enrolled in this study. The patient data including demographic data, gestational age of abortion, methods of abortion, dosage of cytotec usage, indications of abortion and length of hospital stay were recorded. RESULT: M...

  4. Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism.

    Fan, Wenchun; Zhang, Dong; Qian, Ping; Qian, Suhong; Wu, Mengge; Chen, Huanchun; Li, Xiangmin

    2016-03-01

    The tripartite motif protein 21 (TRIM21) is a ubiquitously expressed E3 ubiquitin ligase and an intracellular antibody receptor. TRIM21 mediates antibody-dependent intracellular neutralization (ADIN) in cytosol and provides an intracellular immune response to protect host defense against pathogen infection. In this study, swine TRIM21 (sTRIM21) was cloned and its role in ADIN was investigated. The expression of sTRIM21 is induced by type I interferon in PK-15 cells. sTRIM21 restricts FMDV infection in the presence of FMDV specific antibodies. Furthermore, sTRIM21 interacts with Fc fragment of swine immunoglobulin G (sFc) fused VP1 of FMDV and thereby causing its degradation. Both the RING and SPRY domains are essential for sTRIM21 to degrade sFc-fused VP1. These results suggest that the intracellular neutralization features of FMDV contribute to the antiviral activity of sTRIM21. sTRIM21 provide another intracellular mechanism to inhibit FMDV infection in infected cells. PMID:26777733

  5. Seroprevalence of toxoplasmosis among women with abortion in Khartoum State

    Bahaeldin Khalid Elamin Elhag

    2015-01-01

    Objective: To determine the prevalence of toxoplasmosis and infection among aborted women in order to establish basic knowledge for future pregnancy care. Methods: A retrospective descriptive cross sectional hospital based study was conducted. A total of 95 pregnant women were enrolled in the study from Khartoum Teaching Hospital in the period from January 2012 to January 2013. The entire participant has history of abortion. The data were collected from the patient medical file.ELISA was used forToxoplasma gondii (T. gondii) IgG and IgM using commercial diagnostic kit. Quantitative analysis forT. gondii antibodies IgG and IgM was performed, and the assay result interpreted as IU/mL. Data were analyzed usingSSPS using theChi-square test. Results:A total of 95 participants were tested forT. gondii antibodies. Mean age was (29.93 ± 6.30) years old.T. gondiiIgM was found reactive in 5 participants (5.3%), while 27 participants (28.4%) were found reactive forT. gondii IgG. It was found that the age group of 20-29 and 30-39 had a significant correlation with antibody sero-positive. Conclusions: This study showed a high seroprevalence ofT. gondiiantibodies. Hence this study recommends implementing health program among pregnant women to prevent primary infection during pregnancy and regular surveillance of the disease among population all over the country.

  6. Sex-Selective Abortions to Be Outlawed

    2005-01-01

    China is to outlaw the selective abortion of female fetuses to correct an imbalance in the ratio of boys to girls that has grown since the family planning policy was introduced more than 20 years ago.

  7. Resolution of acute malarial infections by T cell-dependent non-antibody-mediated mechanisms of immunity.

    Cavacini, L A; Parke, L A; Weidanz, W P

    1990-01-01

    While it is generally accepted that acute blood stage malarial infections are resolved through the actions of protective antibodies, we observed that resistance to acute infection with Plasmodium chabaudi adami was mediated by T cell-dependent cellular immune mechanisms independent of antibody. We now report that acute blood stage infections caused by three additional murine hemoprotozoan parasites, Plasmodium vinckei petteri, Plasmodium chabaudi chabaudi, and Babesia microti, appear to be co...

  8. Catholicism and abortion since Roe v. Wade.

    Hisel, L M

    1998-01-01

    This document summarizes a sample of significant activities and events undertaken by Roman Catholics in response to the US Supreme Court's Roe vs. Wade decision legalizing induced abortion. The summaries begin with the 1966 creation of the National Right to Life Committee and cover opposition of Catholic bishops to the Roe decision, the organization of the National Committee for a Human Life Amendment (NCHLA), the mock investiture of a female pope by Catholics for a Free Choice, dismissal of a pro-life priest from the Jesuits, excommunication of various women because of their work with pro-choice agencies or ones that provided abortion services, meetings of the National Conference of Catholic Bishops (NCCB) with presidential candidates, NCHLA lobbying for the Hyde Amendment, open letters and advertisements published by CFC, the effort of Abortion Rights Mobilization to strip the Catholic church of its tax-exempt status, the Vatican order for all priests to leave political office, actions taken by nuns to support the pro-choice position, the proposal of the "seamless garment" argument under the principle of the "consistent ethic of life," initiation of the post-abortion reconciliation project, the actions of Catholic politicians, the filing of amicus curiae briefs, support of bishops for Operation Rescue, forums on abortion conducted by an Archbishop, the Catholic Statement on Pluralism and Abortion, targeting by bishops of pro-choice candidates for sanctions and excommunication, testimony and lobbying in opposition of the Freedom of Choice Act, false accusations about the 1994 International Conference on Population and Development leveled by bishops, lobbying by bishops in support of a ban on late-term abortions, lobbying to increase the access of low-income women to abortion, and consideration by the bishops of reinstituting "meatless Fridays" to express Catholic opposition to "attacks on human life and dignity." PMID:12178893

  9. Access to abortion and secular liberties

    Roberto Arriada Lorea; Michele Andréa Markowitz

    2007-01-01

    In Brazil, facing an issue like abortion requires a secular perspective since the freedom of conscience assured by the Federal Constitution places upon the State the need to regard not only different viewpoints of different religions, but more specifically assure the right to diversity existing within a same religion, as well as the right to exercise different views from those of the hierarchy of his/her own religion. As such, there is no legal barrier for the decriminalization of abortion in...

  10. The Bad Mother: Stigma, Abortion and Surrogacy.

    Abrams, Paula

    2015-01-01

    Stigma taints individuals with a spoiled identity and loss of status or discrimination. This article is the first to examine the stigma attached to abortion and surrogacy and consider how law may stigmatize women for failing to conform to social expectations about maternal roles. Courts should consider evidence of stigma when evaluating laws regulating abortion or surrogacy to determine whether these laws are based on impermissible gender stereotyping. PMID:26242937

  11. Influential Factors in American Abortion Issue

    裴培

    2015-01-01

    The landmark case Roe v.Wade remains one of the most controversial and essential ones in American history.The divergent opinions on abortion also play a crucial part in American political arena.What factors are influencing the dispute about abortion? This essay will thoroughly discuss the factors: the value of freedom and pro-choice and the consideration on women’s self-development; Contrarily,the firm religious faith and the concerns for women’s healt

  12. Influential Factors in American Abortion Issue

    2015-01-01

    The landmark case Roe v.Wade remains one of the most controversial and essential ones in American history. The divergent opinions on abortion also play a crucial part in American political arena.What factors are influencing the dispute about abortion? This essay will thoroughly discuss the factors:the value of freedom and pro-choice and the consideration on women’s self-development; Contrarily,the firm religious faith and the concerns for women’s health.

  13. South African parliament approves sweeping abortion reform.

    1996-11-22

    South Africa's National Assembly voted 209 to 87 for passage of the "Choice on Termination of Pregnancy Act" on October 30; it was passed in the Senate, 49 to 21 (20 abstentions), on November 5. The African National Congress strongly supported the Act, while the National Party opposed it. Under the law, abortions during the first 12 weeks of pregnancy may to be performed by physicians or trained midwives. From week 13 through week 20, a physician, in consultation with the mother, may terminate the pregnancy after determining that continuing the pregnancy would threaten the woman's health (physical or mental) or circumstances (social or economic), or that the fetus is at substantial risk of suffering severe physical or mental abnormalities. Abortion is permitted after 20 weeks if two doctors (or midwives) decide continuing the pregnancy would endanger the mother's life or result in injury or severe malformation of the fetus. Only the pregnant woman's consent is required. Although an abortion provider must advise a young client to consult with parents, guardian, family members, or friends before the procedure, she is not required to comply. All women are to be informed of their rights under the Act; criminal penalties (up to 10 years) are mandated for unauthorized abortion providers, for persons who prevent a lawful abortion, or for those who obstruct access to an abortion facility. The new statute repeals the more restrictive Abortion and Sterilization Act of 1975, which permitted abortion only in cases of maternal life or health endangerment, severe fetal abnormality, rape, incest, or mental incapacity. PMID:12292092

  14. Immediate vs. delayed insertion of intrauterine contraception after second trimester abortion: study protocol for a randomized controlled trial

    Soon Judith A

    2011-06-01

    Full Text Available Abstract Background We describe the rationale and protocol for a randomized controlled trial (RCT to assess whether intrauterine contraception placed immediately after a second trimester abortion will result in fewer pregnancies than current recommended practice of intended placement at 4 weeks post-abortion. Decision analysis suggests the novel strategy could substantially reduce subsequent unintended pregnancies and abortions. This paper highlights considerations of design, implementation and evaluation of a trial expected to provide rigorous evidence for appropriate insertion timing and health economics of intrauterine contraception after second trimester abortion. Methods/Design Consenting women choosing to use intrauterine contraception after abortion for a pregnancy of 12 to 24 weeks will be randomized to insertion timing groups either immediately (experimental intervention or four weeks (recommended care post abortion. Primary outcome measure is pregnancy rate at one year. Secondary outcomes include: cumulative pregnancy rates over five year follow-up period, comprehensive health economic analyses comparing immediate and delayed insertion groups, and device retention rates, complication rates (infection, expulsion and, contraceptive method satisfaction. Web-based Contraception Satisfaction Questionnaires, clinical records and British Columbia linked health databases will be used to assess primary and secondary outcomes. Enrolment at all clinics in the province performing second trimester abortions began in May 2010 and is expected to complete in late 2011. Data on one year outcomes will be available for analysis in 2014. Discussion The RCT design combined with access to clinical records at all provincial abortion clinics, and to information in provincial single-payer linked administrative health databases, birth registry and hospital records, offers a unique opportunity to evaluate such an approach by determining pregnancy rate at one

  15. Abortion and anxiety: what's the relationship?

    Steinberg, Julia Renee; Russo, Nancy F

    2008-07-01

    Using data from the United States National Survey of Family Growth (NSFG) and the National Comorbidity Survey (NCS), we conducted secondary data analyses to examine the relationship of abortion, including multiple abortions, to anxiety after first pregnancy outcome in two studies. First, when analyzing the NSFG, we found that pre-pregnancy anxiety symptoms, rape history, age at first pregnancy outcome (abortion vs. delivery), race, marital status, income, education, subsequent abortions, and subsequent deliveries accounted for a significant association initially found between first pregnancy outcome and experiencing subsequent anxiety symptoms. We then tested the relationship of abortion to clinically diagnosed generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD), and social anxiety disorder, using NCS data. Contrary to findings from our analyses of the NSFG, in the NCS analyses we did not find a significant relationship between first pregnancy outcome and subsequent rates of GAD, social anxiety, or PTSD. However, multiple abortions were found to be associated with much higher rates of PTSD and social anxiety; this relationship was largely explained by pre-pregnancy mental health disorders and their association with higher rates of violence. Researchers and clinicians need to learn more about the relations of violence exposure, mental health, and pregnancy outcome to avoid attributing poor mental health solely to pregnancy outcomes. PMID:18468755

  16. The abortion debate in the Dominican Republic.

    1992-01-01

    Faced with a situation in which an estimated 60,000 illegal abortions (a major cause of maternal mortality) were performed annually, the Dominican Republic has adopted a new Health Code which contains a chapter dedicated to maternal health. Included in the new code are cases in which abortion is allowed: 1) when 2 specialists affirm that the pregnancy or childbirth constitutes a risk to the mother's health or life; 2) if the medical history of the parents and 2 doctors confirm the likelihood of the baby being born seriously disabled or deformed; or 3) if the mother's mental health is put in jeopardy by continuing the pregnancy. Despite the disapproval of church representatives, the legalization of abortion was unanimously approved by the Congress. The debate which surrounded the process was increased by a petition signed by more than 260 women decrying the lack of input that women had in the decision-making process. Women's action groups have been trying to widen the context in which the political discussion is taking place to stress the importance of viewing abortion from a reproductive rights perspective. The women's groups wish to prevent a situation in which the discussion surrounding the issue will be limited to legislators and church leaders. The women have pointed out that women should make the decisions about their lives and their bodies. In the meantime, the president of the Congress predicts that illegal abortion will continue in the Dominican Republic regardless of the current provisions for legal abortion. PMID:12286344

  17. Induced abortion and subsequent pregnancy duration

    Zhou, Wei Jin; Sørensen, Henrik Toft; Olsen, Jørn

    1999-01-01

    OBJECTIVE: To examine whether induced abortion influences subsequent pregnancy duration. METHODS: Women who had their first pregnancies during 1980, 1981, and 1982 were identified in three Danish national registries. A total of 15,727 women whose pregnancies were terminated by first-trimester ind......OBJECTIVE: To examine whether induced abortion influences subsequent pregnancy duration. METHODS: Women who had their first pregnancies during 1980, 1981, and 1982 were identified in three Danish national registries. A total of 15,727 women whose pregnancies were terminated by first......-trimester induced abortions were compared with 46,026 whose pregnancies were not terminated by induced abortions. All subsequent pregnancies until 1994 were identified by register linkage. RESULTS: Preterm and post-term singleton live births were more frequent in women with one, two, or more previous induced...... abortions. After adjusting for potential confounders and stratifying by gravidity, the odds ratios of preterm singleton live births in women with one, two, or more previous induced abortions were 1.89 (95% confidence interval [CI] 1.70, 2.11), 2.66 (95% CI 2.09, 3.37), and 2.03 (95% CI 1.29, 3...

  18. Abortion in Vietnam: measurements, puzzles, and concerns.

    Goodkind, D

    1994-01-01

    This report summarizes current knowledge about abortion in Vietnam, drawing upon government statistics, survey data, and fieldwork undertaken by the author in Vietnam throughout 1993 and part of 1994. The official total abortion rate in Vietnam in 1992 was about 2.5 per woman, the highest in Asia and worrisome for a country with a still-high total fertility rate of 3.7 children per woman. Vietnamese provinces exhibited substantial variation in both the rate of abortion and the type of procedures performed. Among the hypotheses explored to explain Vietnam's high rate of abortion are the borrowing of family planning strategies from other poor socialist states where abortion is common; current antinatal population policies that interact with a lack of contraceptive alternatives; and a rise in pregnancies among young and unmarried women in the wake of recent free-market reforms. Because family-size preferences are still declining, abortion rates may continue to increase unless the incidence of unwanted pregnancy can be reduced, a goal that Vietnamese population specialists are seeking to achieve. PMID:7716799

  19. A novel mechanism inducing genome instability in Kaposi's sarcoma-associated herpesvirus infected cells.

    Brian R Jackson

    2014-05-01

    Full Text Available Kaposi's sarcoma-associated herpesvirus (KSHV is an oncogenic herpesvirus associated with multiple AIDS-related malignancies. Like other herpesviruses, KSHV has a biphasic life cycle and both the lytic and latent phases are required for tumorigenesis. Evidence suggests that KSHV lytic replication can cause genome instability in KSHV-infected cells, although no mechanism has thus far been described. A surprising link has recently been suggested between mRNA export, genome instability and cancer development. Notably, aberrations in the cellular transcription and export complex (hTREX proteins have been identified in high-grade tumours and these defects contribute to genome instability. We have previously shown that the lytically expressed KSHV ORF57 protein interacts with the complete hTREX complex; therefore, we investigated the possible intriguing link between ORF57, hTREX and KSHV-induced genome instability. Herein, we show that lytically active KSHV infected cells induce a DNA damage response and, importantly, we demonstrate directly that this is due to DNA strand breaks. Furthermore, we show that sequestration of the hTREX complex by the KSHV ORF57 protein leads to this double strand break response and significant DNA damage. Moreover, we describe a novel mechanism showing that the genetic instability observed is a consequence of R-loop formation. Importantly, the link between hTREX sequestration and DNA damage may be a common feature in herpesvirus infection, as a similar phenotype was observed with the herpes simplex virus 1 (HSV-1 ICP27 protein. Our data provide a model of R-loop induced DNA damage in KSHV infected cells and describes a novel system for studying genome instability caused by aberrant hTREX.

  20. Perinatal acquisition of drug-resistant HIV-1 infection: mechanisms and long-term outcome

    Dollfus Catherine

    2009-09-01

    Full Text Available Abstract Background Primary-HIV-1-infection in newborns that occurs under antiretroviral prophylaxis that is a high risk of drug-resistance acquisition. We examine the frequency and the mechanisms of resistance acquisition at the time of infection in newborns. Patients and Methods We studied HIV-1-infected infants born between 01 January 1997 and 31 December 2004 and enrolled in the ANRS-EPF cohort. HIV-1-RNA and HIV-1-DNA samples obtained perinatally from the newborn and mother were subjected to population-based and clonal analyses of drug resistance. If positive, serial samples were obtained from the child for resistance testing. Results Ninety-two HIV-1-infected infants were born during the study period. Samples were obtained from 32 mother-child pairs and from another 28 newborns. Drug resistance was detected in 12 newborns (20%: drug resistance to nucleoside reverse transcriptase inhibitors was seen in 10 cases, non-nucleoside reverse transcriptase inhibitors in two cases, and protease inhibitors in one case. For 9 children, the detection of the same resistance mutations in mothers' samples (6 among 10 available and in newborn lymphocytes (6/8 suggests that the newborn was initially infected by a drug-resistant strain. Resistance variants were either transmitted from mother-to-child or selected during subsequent temporal exposure under suboptimal perinatal prophylaxis. Follow-up studies of the infants showed that the resistance pattern remained stable over time, regardless of antiretroviral therapy, suggesting the early cellular archiving of resistant viruses. The absence of resistance in the mother of the other three children (3/10 and neonatal lymphocytes (2/8 suggests that the newborns were infected by a wild-type strain without long-term persistence of resistance when suboptimal prophylaxis was stopped. Conclusion This study confirms the importance of early resistance genotyping of HIV-1-infected newborns. In most cases (75%, drug

  1. Unsafe abortion and postabortion care-An overview

    Rasch, Vibeke

    2011-01-01

    Forty percent of the world's women are living in countries with restrictive abortion laws, which prohibit abortion or only allow abortion to protect a woman's life or her physical or mental health. In countries where abortion is restricted, women have to resort to clandestine interventions to have...... an unwanted pregnancy terminated. As a consequence, high rates of unsafe abortion are seen, such as in sub-Saharan Africa where unsafe abortion occurs at rates of 18-39/1 000 women. The circumstances under which women obtain unsafe abortion vary and depend on traditional methods known and type of...... providers present. Health professionals are prone to use instrumental procedures to induce the abortion, whereas traditional providers often make a brew of herbs to be drunk in one or more doses. In countries with restrictive abortion laws, high rates of maternal death must be expected and globally an...

  2. Women's Private Conversations about Abortion: A Qualitative Study.

    Herold, Stephanie; Kimport, Katrina; Cockrill, Kate

    2015-01-01

    Abortion is a relatively frequent experience, yet public discourse about abortion is contentious and stigmatizing. Little literature is available on private conversations about abortion, which may be distinct from public discourse. We explored private discourse by documenting the nature of women's discussions about abortion with peers in a book club. We recruited thirteen women's book clubs in nine states. Participants (n = 119) read the book Choice: True Stories of Birth, Contraception, Infertility, Adoption, Single Parenthood, & Abortion, and participated in a book club meeting, which we audio-recorded and transcribed. Data collection occurred between April 2012 and April 2013. In contrast to public discourse of abortion, private discourse was nuanced and included disclosures of multiple kinds of experiences with abortion. Participants disclosed having abortions, considering abortion as an option for past or future pregnancies, and supporting others through an abortion. Distinguishing between public and private discourse enabled us to identify that an "abortion experience" could include personal decisions, hypothetical decisions, or connection with someone having an abortion. The book club atmosphere provided a rare opportunity for participants to explore their relationship to abortion. More research is needed to understand the role of private discourse in reducing abortion stigma. PMID:26086582

  3. [Conscientious objection in the matter of abortion].

    Serrano Gil, A; García Casado, M L

    1992-03-01

    The issue of conscientious objection in Spain has been used by pro-choice groups against objecting health personnel as one of the obstacles to the implementation of the abortion law, a misnomer. At present objection is massive in the public sector; 95% of abortions are carried out in private clinics with highly lucrative returns; abortion tourism has decreased; and false objection has proliferated in the public sector when the objector performs abortions in the private sector for high fees. The legal framework for conscientious objection is absent in Spain. Neither Article 417 of the Penal Code depenalizing abortion, nor the Ministerial Decree of July 31, 1985, nor the Royal Decree of November 21, 1986 recognize such a concept. However, the ruling of the Constitutional Court on April 11, 1985 confirmed that such objection can be exercised with independence. Some authors refer to the applicability of Law No. 48 of December 16, 1984 that regulates conscientious objection in military service to health personnel. The future law concerning the fundamental right of ideological and religious liberty embodied in Article 16.1 of the Constitution has to be revised. A draft bill was submitted in the Congress or Representatives concerning this issue on May 3, 1985 that recognizes the right of medical personnel to object to abortion without career repercussions. Another draft bill was introduced on April 17, 1985 that would allow the nonparticipation of medical personnel in the interruption of pregnancy, however, they would be prohibited from practicing such in the private hospitals. Neither of these proposed bills became law. Professional groups either object unequivocally, or do not object at all, or object on an ethical level but do not object to therapeutic abortion. The resolution of this issue has to be by consensus and not by imposition. PMID:1565971

  4. Infectivity versus Seeding in Neurodegenerative Diseases Sharing a Prion-Like Mechanism

    Natalia Fernández-Borges

    2013-01-01

    Full Text Available Prions are considered the best example to prove that the biological information can be transferred protein to protein through a conformational change. The term “prion-like” is used to describe molecular mechanisms that share similarities with the mammalian prion protein self-perpetuating aggregation and spreading characteristics. Since prions are presumably composed only of protein and are infectious, the more similar the mechanisms that occur in the different neurodegenerative diseases, the more these processes will resemble an infection. In vitro and in vivo experiments carried out during the last decade in different neurodegenerative disorders such as Alzheimer's disease (AD, Parkinson's diseases (PD, and amyotrophic lateral sclerosis (ALS have shown a convergence toward a unique mechanism of misfolded protein propagation. In spite of the term “infection” that could be used to explain the mechanism governing the diversity of the pathological processes, other concepts as “seeding” or “de novo induction” are being used to describe the in vivo propagation and transmissibility of misfolded proteins. The current studies are demanding an extended definition of “disease-causing agents” to include those already accepted as well as other misfolded proteins. In this new scenario, “seeding” would be a type of mechanism by which an infectious agent can be transmitted but should not be used to define a whole “infection” process.

  5. Mechanism of action and application of virocids in health care-associated viral infections

    Babak Shahbaz

    2016-03-01

    Full Text Available Viruses are important causes of acute and chronic diseases in humans. Newer viruses are still being discovered. Apart from frequently causing infections in the general community, many types of viruses are significant nosocomial pathogens that with emerging viruses has become a real issue in medical field. There are specific treatments, vaccine and physical barrier to fight some of these infections. Health care-associated viral infections are an important source of patient’s morbidity and mortality. The method of sterilization or disinfection depends on the intended use of the medical devices (comprising critical, semicritical and noncritical items and failure to perform proper sterilization or disinfection of these items may leads to introduction of viruses, resulting in infection. Disinfection is an essential way in reducing or disruption of transmission of viruses by environmental surfaces, instruments and hands which achieves by chemical disinfectants and antiseptics, respectively. This review discusses about chemical agents with virocids properties (e.g. alcohols, chlorine compounds, formaldehyde, phenolic compounds, glutaraldehyde, ortho-phthaldehyde, hydrogen peroxide, peracetic acid, iodophor, ammonium compounds quaternary, bigunides and so on., mechanisms of action and their applications in health care-associated viral infection control. As well as, we described an overview for hierarchy of viruses in challenge with disinfantans, effective agents on viral inactivation, i.e.targect viruses, viral stability or survival duration time in enviromental surfaces and hands. We explained disinfection of surfaces, challenges in emerging viral pathogens inactivation, viral resistance to chemical disinfectants and antiseptics. Because, there are laboratory studies and clinical evidences for some viruses which viral resistance to biocide or failure to perform proper disinfection can lead to infection outbreaks. Also, we described virucidal

  6. A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood.

    Kerstin Hünniger

    2014-02-01

    Full Text Available Candida albicans bloodstream infection is increasingly frequent and can result in disseminated candidiasis associated with high mortality rates. To analyze the innate immune response against C. albicans, fungal cells were added to human whole-blood samples. After inoculation, C. albicans started to filament and predominantly associate with neutrophils, whereas only a minority of fungal cells became attached to monocytes. While many parameters of host-pathogen interaction were accessible to direct experimental quantification in the whole-blood infection assay, others were not. To overcome these limitations, we generated a virtual infection model that allowed detailed and quantitative predictions on the dynamics of host-pathogen interaction. Experimental time-resolved data were simulated using a state-based modeling approach combined with the Monte Carlo method of simulated annealing to obtain quantitative predictions on a priori unknown transition rates and to identify the main axis of antifungal immunity. Results clearly demonstrated a predominant role of neutrophils, mediated by phagocytosis and intracellular killing as well as the release of antifungal effector molecules upon activation, resulting in extracellular fungicidal activity. Both mechanisms together account for almost [Formula: see text] of C. albicans killing, clearly proving that beside being present in larger numbers than other leukocytes, neutrophils functionally dominate the immune response against C. albicans in human blood. A fraction of C. albicans cells escaped phagocytosis and remained extracellular and viable for up to four hours. This immune escape was independent of filamentation and fungal activity and not linked to exhaustion or inactivation of innate immune cells. The occurrence of C. albicans cells being resistant against phagocytosis may account for the high proportion of dissemination in C. albicans bloodstream infection. Taken together, iterative experiment

  7. Update on infections caused by Stenotrophomonas maltophilia with particular attention to resistance mechanisms and therapeutic options.

    Chang, Ya-Ting; Lin, Chun-Yu; Chen, Yen-Hsu; Hsueh, Po-Ren

    2015-01-01

    Stenotrophomonas maltophilia is a Gram-negative, biofilm-forming bacterium. Although generally regarded as an organism of low virulence, S. maltophilia is an emerging multi-drug resistant opportunistic pathogen in hospital and community settings, especially among immunocompromised hosts. Risk factors associated with S. maltophilia infection include underlying malignancy, cystic fibrosis, corticosteroid or immunosuppressant therapy, the presence of an indwelling central venous catheter and exposure to broad spectrum antibiotics. In this review, we provide a synthesis of information on current global trends in S. maltophilia pathogenicity as well as updated information on the molecular mechanisms contributing to its resistance to an array of antimicrobial agents. The prevalence of S. maltophilia infection in the general population increased from 0.8-1.4% during 1997-2003 to 1.3-1.68% during 2007-2012. The most important molecular mechanisms contributing to its resistance to antibiotics include β-lactamase production, the expression of Qnr genes, and the presence of class 1 integrons and efflux pumps. Trimethoprim/sulfamethoxazole (TMP/SMX) is the antimicrobial drug of choice. Although a few studies have reported increased resistance to TMP/SMX, the majority of studies worldwide show that S. maltophilia continues to be highly susceptible. Drugs with historically good susceptibility results include ceftazidime, ticarcillin-clavulanate, and fluoroquinolones; however, a number of studies show an alarming trend in resistance to those agents. Tetracyclines such as tigecycline, minocycline, and doxycycline are also effective agents and consistently display good activity against S. maltophilia in various geographic regions and across different time periods. Combination therapies, novel agents, and aerosolized forms of antimicrobial drugs are currently being tested for their ability to treat infections caused by this multi-drug resistant organism. PMID:26388847

  8. Update on infections caused by Stenotrophomonas maltophilia with particular attention to resistance mechanisms and therapeutic options

    Ya Ting eChang

    2015-09-01

    Full Text Available Stenotrophomonas maltophilia is a Gram-negative, biofilm-forming bacterium. Although generally regarded as an organism of low virulence, S. maltophilia is an emerging multi-drug resistant opportunistic pathogen in hospital and community settings, especially among immunocompromised hosts. Risk factors associated with S. maltophilia infection include underlying malignancy, cystic fibrosis, corticosteroid or immunosuppressant therapy, the presence of an indwelling central venous catheter and exposure to broad spectrum antibiotics. In this review, we provide a synthesis of information on current global trends in S. maltophilia pathogenicity as well as updated information on the molecular mechanisms contributing to its resistance to an array of antimicrobial agents. The prevalence of S. maltophilia infection in the general population increased from 0.8%-1.4% during 1997-2003 to 1.3%-1.68% during 2007-2012. The most important molecular mechanisms contributing to its resistance to antibiotics include β-lactamase production, the expression of Qnr genes, and the presence of class 1 integrons and efflux pumps. Trimethoprim/sulfamethoxazole (TMP/SMX is the antimicrobial drug of choice. Although a few studies have reported increased resistance to TMP/SMX, the majority of studies worldwide show that S. maltophilia continues to be highly susceptible. Drugs with historically good susceptibility results include ceftazidime, ticarcillin-clavulanate, and fluoroquinolones; however, a number of studies show an alarming trend

  9. Current views on the mechanisms of immune responses to trauma and infection.

    Binkowska, Aneta Małgorzata; Michalak, Grzegorz; Słotwiński, Robert

    2015-01-01

    According to the World Health Organization, post-traumatic mortality rates are still very high and show an increasing tendency. Disorders of innate immune response that may increase the risk of serious complications play a key role in the immunological system response to trauma and infection. The mechanism of these disorders is multifactorial and is still poorly understood. The changing concepts of systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response syndrome (CARS) early inflammatory response, presented in this work, have been extended to genetic studies. Overexpression of genes and increased production of immune response mediators are among the main causes of multiple organ dysfunction syndrome (MODS). Changes in gene expression detected early after injury precede the occurrence of subsequent complications with a typical clinical picture. Rapid depletion of energy resources leads to immunosuppression and persistent inflammation and immune suppression catabolism syndrome (PICS). Early diagnosis of immune disorders and appropriate nutritional therapy can significantly reduce the incidence of complications, length of hospital stay, and mortality. The study presents the development of knowledge and current views explaining the mechanisms of the immune response to trauma and infection. PMID:26557036

  10. [About da tai - abortion in old Chinese folk medicine handwritten manuscripts].

    Zheng, Jinsheng

    2013-01-01

    Of 881 Chinese handwritten volumes with medical texts of the 17th through mid-20th century held by Staatsbibliothek zu Berlin and Ethnologisches Museum Berlin-Dahlem, 48 volumes include prescriptions for induced abortion. A comparison shows that these records are significantly different from references to abortion in Chinese printed medical texts of pre-modern times. For example, the percentage of recipes recommended for artificial abortions in handwritten texts is significantly higher than those in printed medical books. Authors of handwritten texts used 25 terms to designate artificial abortion, with the term da tai [see text], lit.: "to strike the fetus", occurring most frequently. Its meaning is well defined, in contrast to other terms used, such as duo tai [see text], lit: "to make a fetus fall", xia tai [see text], lit. "to bring a fetus down", und duan chan [see text], lit., to interrupt birthing", which is mostly used to indicate a temporary or permanent sterilization. Pre-modern Chinese medicine has not generally abstained from inducing abortions; physicians showed a differentiating attitude. While abortions were descibed as "things a [physician with an attitude of] humaneness will not do", in case a pregnancy was seen as too risky for a woman she was offered medication to terminate this pregnancy. The commercial application of abortifacients has been recorded in China since ancient times. A request for such services has continued over time for various reasons, including so-called illegitimate pregnancies, and those by nuns, widows and prostitutes. In general, recipes to induce abortions documented in printed medical literature have mild effects and are to be ingested orally. In comparison, those recommended in handwritten texts are rather toxic. Possibly to minimize the negative side-effects of such medication, practitioners of folk medicine developed mechanical devices to perform "external", i.e., vaginal approaches. PMID:24195336

  11. Abortion in Brazil: legislation, reality and options.

    Guedes, A C

    2000-11-01

    Abortion is illegal in Brazil except when performed to save the woman's life or in cases of rape. This paper gives a brief history of parliamentary and extra-parliamentary efforts to change abortion-related legislation in Brazil in the past 60 years, the contents of some of the 53 bills that have been tabled in that time, the non-governmental stakeholders involved and the debate itself in recent decades. The authorities in Brazil have never assumed full public responsibility for reproductive health care or family planning, let alone legal abortion; the ambivalence of the medical profession is an important obstacle. Most politicians avoid getting involved in the abortion debate, but the majority of bills in the 1990s have favoured less restrictive legislation. Incremental legislative and health service changes could help to improve the situation for women. Advocacy is probably the most important action, to promote an environment conducive to change. Clandestine abortion is a serious public health problem in Brazil, and the inadequacy of family planning services is one of the causes of this problem. The solutions should be made a priority for the Brazilian public health system. PMID:11424252

  12. Access to abortion services: abortions performed by mid-level practitioners.

    Kowalczyk, E A

    1993-01-01

    Because the number of physicians available to perform abortions in the US is dwindling, certified nurse-midwives, nurse practitioners, and physician assistants should be trained and permitted to perform abortions. Roadblocks to this change are the fact that the Supreme Court would likely allow states to prevent mid-level practitioners from performing abortions in the name of protecting the health of the mother. Also, existing statutes would probably not be interpreted by courts to allow mid-level practitioners to perform abortions. However, physician assistants have been performing abortions in Vermont since 1975, and a 1981-82 comparative study affirmed that physician assistants are well-equipped to perform abortions (of 2458 procedures, the complication rate/1000 was 27.4 for physician assistants and 30.8 for physicians). However, controversy surrounds the provision of abortion by these physician assistants in Vermont, since the relevant statute suggests that abortion is illegal unless performed by a physician. However, the statute has not been changed since Roe vs. Wade and is likely unconstitutional. Court cases in Missouri and Tennessee suggest that courts may be willing to include abortion within the scope of progressive nursing practice acts, but a recent similar case in Massachusetts resulted in a narrow interpretation of nursing practice statutes. Because the definition of professional nursing varies with each state statute, it will be a formidable task to convince every jurisdiction to include abortion as a permissible mid-level practice. Even in Vermont, the nursing practice statute defines in an exclusive list what services the professional nurse may perform (whereas the physician assistant regulations limit their scope of practice only to that delegated by a supervising physician). States could, of course, pass statutes which include abortion as a permissible practice for the mid-level practitioner. However, specific legislation would provide a clear

  13. Induction of partial protection against infection with Toxoplasma gondii genotype II by DNA vaccination with recombinant chimeric tachyzoite antigens

    Rosenberg, Carina Agerbo; De Craeye, S.; Jongert, E.; Gargano, N.; Beghetto, E.; Del Porto, P.; Vorup-Jensen, Thomas; Petersen, Jørgen Eskild

    2009-01-01

    Infection with the obligate intracellular parasite Toxoplasma gondii is a significant source of parasitic infections worldwide. In adults, infections may often lead to severe retinochoroiditis. Infection of the foetus causes abortion or congenital pathology that may lead to neurological complicat......Infection with the obligate intracellular parasite Toxoplasma gondii is a significant source of parasitic infections worldwide. In adults, infections may often lead to severe retinochoroiditis. Infection of the foetus causes abortion or congenital pathology that may lead to neurological...

  14. Application of Fault Management Theory to the Quantitative Selection of a Launch Vehicle Abort Trigger Suite

    Lo, Yunnhon; Johnson, Stephen B.; Breckenridge, Jonathan T.

    2014-01-01

    The theory of System Health Management (SHM) and of its operational subset Fault Management (FM) states that FM is implemented as a "meta" control loop, known as an FM Control Loop (FMCL). The FMCL detects that all or part of a system is now failed, or in the future will fail (that is, cannot be controlled within acceptable limits to achieve its objectives), and takes a control action (a response) to return the system to a controllable state. In terms of control theory, the effectiveness of each FMCL is estimated based on its ability to correctly estimate the system state, and on the speed of its response to the current or impending failure effects. This paper describes how this theory has been successfully applied on the National Aeronautics and Space Administration's (NASA) Space Launch System (SLS) Program to quantitatively estimate the effectiveness of proposed abort triggers so as to select the most effective suite to protect the astronauts from catastrophic failure of the SLS. The premise behind this process is to be able to quantitatively provide the value versus risk trade-off for any given abort trigger, allowing decision makers to make more informed decisions. All current and planned crewed launch vehicles have some form of vehicle health management system integrated with an emergency launch abort system to ensure crew safety. While the design can vary, the underlying principle is the same: detect imminent catastrophic vehicle failure, initiate launch abort, and extract the crew to safety. Abort triggers are the detection mechanisms that identify that a catastrophic launch vehicle failure is occurring or is imminent and cause the initiation of a notification to the crew vehicle that the escape system must be activated. While ensuring that the abort triggers provide this function, designers must also ensure that the abort triggers do not signal that a catastrophic failure is imminent when in fact the launch vehicle can successfully achieve orbit. That is

  15. Factors contributes to spontaneous abortion caused by Listeria monocytogenes, in Tehran, Iran, 2015.

    Pourkaveh, B; Ahmadi, M; Eslami, G; Gachkar, L

    2016-01-01

    Spontaneous abortion is the loss of a fetus before the 20th week of pregnancy, when occurring naturally without any surgical or pharmaceutical intervention. On the other hand, Listeria monocytogenes, as one of the foodborne pathogens, is a causative agent of listeriosis. The transfer of L. monocytogenes in pregnant women occurs as self-limited flu-like symptoms which may result in abortion, stillbirth or premature birth of infected infants. The purpose of this study was the identification of Listeria monocytogenes risk factors in women with spontaneous abortion admitted to Tehran Province health care centers in 2015. In this cross-sectional study, 317 women were examined for L. monocytogenes using Polymerase Chain Reaction (PCR) and the related risk factors. Two questionnaires on "L. monocytogenes Probable Risk Factors" and "Socio Economic Factors" were completed. Out of 317 samples of vaginal swabs, 54 (17%) isolates of L. monocytogenes were identified. In addition significant differences in terms of age of mother and her husband, mother and the husband's level of education , house prices, place of residence, gestational age of first abortion, gestational age of current abortion, gestational age of second abortion, consumption of unpasteurized dairy products, consumption of feta and soft cheese, consumption of smoked see food products, consumption of processed meat products and half-cooked meat products, consumption of ready-to-eat vegetables, history of contact with domestic animals three month before pregnancy and during pregnancy and consumption of smoked meat products during pregnancy were studied between two groups of patients positive and negative with L. monocytogens (P < 0.001). Based on the study, the detection of L. monocytogens risk factor during pregnancy as well as taking the issue into account while giving information and counseling in pregnancy can be vital to reduce the incidence of this bacterium and subsequently its side effects during

  16. Expression of AIF-1 and RANTES in Unexplained Spontaneous Abortion and Possible Association with Alloimmune Abortion

    Yong-hong LI; Hai-lin WANG; Ya-juan ZHANG

    2007-01-01

    Objective To investigate the effects of allograft inflammatory factor-1(AIF-1)and (RANTES) in sera and deciduas on unexplained early spontaneous abortion.Methods AIF-1 and RANTES were examined in sera and deciduas/endometria of 43 unexplained early spontaneous abortion women (group A),40 healthy women with early pregnancy(group B)and 20 healthy women with no pregnancy (group C). Immunohistochemistry and enzyme linked immunosorbent assay (ELISA) were used in this study. Results AIF-1 protein was expressed both in deciduas of group A and in endometria of group C.In group A, H scores in the recurrent abortion deciduas specimens were significantly greater than those in the first abortion;in endometrium,expression of AIF-1 was greater in the secretory than in proliferative phase of group C.In group B,concentrations of RANTES in sera were higher in 7th-8th week of pregnancy than in 6th-7th and >8th week of pregnancy;expression of AIF-1 protein showed a negative correlation with RASNTES concentration;a significant increase of the RANTES levels in sera and tissue was observed in group B. Conclusion These results demonstrate, for the first time,that AIF-1 are expressed in deciduas of unexplained spontaneous abortion suggesting that AIF-1 involve in alloimmune abortion; RANTES might act as a novel blocking antibody;AIF-1 and RANTES might act as reliable markers for diagnosis of early alloimmune abortion.

  17. Patterns of leaf-pathogen infection in the understory of a Mexican rain forest: incidence, spatiotemporal variation, and mechanisms of infection.

    García-Guzmán, G; Dirzo, R

    2001-04-01

    This study assessed the levels of damage by leaf pathogens and their variability in terms of host species, space (four mature forest sites) and season of the year (dry and rainy), and the mechanisms of infection in the understory of the Los Tuxtlas tropical rain forest. Sixty-five percent of the species surveyed in the dry season (N = 49) and 64.9% of those surveyed in the rainy season (N = 57) were damaged by fungi. Leaf area damaged per plant, on average, was <1% (range: 0.25-20.52%). There was considerable variation in the degree of infection among species, but not among sites and seasons. The survey showed that 43% of the leaves were damaged by herbivores and pathogens concurrently, 16% showed damage by insect herbivory alone, and only 1.4% of the sampled leaves showed damage by pathogens alone. Pathogenicity assays experimentally confirmed that the predominant mechanism of fungal establishment was wounding, such as that caused by herbivory (or other similar sources), and only rarely did infection occur through direct contact (without wounds). The results revealed the omnipresence of leaf fungal infection, although with low damage per plant, and the importance of herbivorous insects in the facilitation of fungal infection in tropical understory plants. PMID:11302849

  18. [Abortion as it is described to us].

    Six-Quivy, M; Macaigne, M; Playoust, D; Zylberberg, G

    1980-01-01

    The French law legalizing abortion provided for a meeting between patient and social counselor prior to the intervention. Aim of this provision was to allow a women to see more clearly into herself, and to allow a social worker to help the patient make a personal and wise decision. Most women come to this encounter with feelings of guilt, anxiety, and depression; most of them want abortion because they know they can have one, and medical reasons for abortion are practacally nonexistant. The emotional situation of the couple, more than their socioeconomic condition, does have a great importance in making a final decision. A discussion can sometimes help, but the responsibility of the decision is with the women's alone. PMID:7401902

  19. The politics of abortion and contraception

    Drezgić Rada

    2004-01-01

    Full Text Available In this article the author challenges several dominant positions that are relevant for understanding demographic trends and contraceptive practices as well as their mutual relationship. First, the author rejects the assumed direct connection between high abortion rates and low fertility. Second, the author challenges the thesis according to which abortions come about because of the lack of contraception and proposes that high abortion rates result from failing contraception i.e. from high failing rates of coitus interruptus which is a preferred method of birth control by men and women in Serbia. Finally, the author argues that giving control over reproductive risk to men does not make women passive victims of male domination. Rather women are, it is argued, active agents in reproducing hegemonic gender roles and relations. In addition, the author shows how gender power relations formed at the micro level may be consequential for macro level politics.

  20. Medical abortion. defining success and categorizing failures

    Rørbye, Christina; Nørgaard, Mogens; Vestermark, Vibeke;

    2003-01-01

    Medical abortion was performed in 461 consecutive women with gestational age LT /= 63 days using a regimen of mifepristone 600 mg followed 2 days later by gemeprost 1 mg vaginally. Success, defined as no surgical intervention, declined from 98.7% after 2 weeks to 94.6% after 15 weeks. The...... difference in short- and long-term success rates increased with increasing gestational age. The majority of failures (76%) were diagnosed more than 2 weeks after initiation of the abortion. At a 2-week follow-up visit, the women who turned out to be failures had a larger endometrial width, higher beta......-hCG values and smaller reductions of beta-hCG than those treated successfully. To optimize comparison of success rates after different medical abortion regimens, we suggest that the criteria for success are stated clearly, that the success rates are stratified according to gestational age and that the...

  1. Diagnostic categorization of post-abortion syndrome.

    Gómez Lavín, C; Zapata García, R

    2005-01-01

    Some psychopathological characteristics are frequently observed in women who have voluntarily aborted. However, some resistance currently remains to their recognition as a differentiated nosological category, known as Post-Abortion Syndrome (PAS). We tried to assign a diagnostic category to women with PAS by determining the extent by which they fulfilled the diagnostic criteria of international classifications. Criteria for Post-Traumatic Stress Disorder (PTSD) were met in the ten PAS cases studied. In addition, patients also showed other non-specific symptoms such as repeated and persistent dreams and nightmares related with the abortion, intense feelings of guilt and the "need to repair". PAS should be considered as an additional type of PTSD. It also has some specific characteristics that could help to understand the patient's life experience and to establish a psychotherapeutic intervention. PMID:15999304

  2. Access to abortion and secular liberties

    Roberto Arriada Lorea

    2007-01-01

    Full Text Available In Brazil, facing an issue like abortion requires a secular perspective since the freedom of conscience assured by the Federal Constitution places upon the State the need to regard not only different viewpoints of different religions, but more specifically assure the right to diversity existing within a same religion, as well as the right to exercise different views from those of the hierarchy of his/her own religion. As such, there is no legal barrier for the decriminalization of abortion in the country. It is up to legislators to reform the present law and decriminalize abortion, assuming the commitments Brazil has assumed with international human-rights organizations, thus assuring the efficacy of civil liberties.

  3. Medical abortion and the risk of subsequent adverse pregnancy outcomes

    Virk, Jasveer; Zhang, Jun; Olsen, Jørn

    2007-01-01

    identified all women living in Denmark who had undergone an abortion for nonmedical reasons between 1999 and 2004 and obtained information regarding subsequent pregnancies from national registries. Risks of ectopic pregnancy, spontaneous abortion, preterm birth (at <37 weeks of gestation), and low birth...... weight (<2500 g) in the first subsequent pregnancy in women who had had a first-trimester medical abortion were compared with risks in women who had had a first-trimester surgical abortion. RESULTS: Among 11,814 pregnancies in women who had had a previous first-trimester medical abortion (2710 women) or...... pregnancies, gestational age at abortion, parity, cohabitation status, and urban or nonurban residence, medical abortion was not associated with a significantly increased risk of ectopic pregnancy (relative risk, 1.04; 95% confidence interval [CI], 0.76 to 1.41), spontaneous abortion (relative risk, 0.87; 95...

  4. Uterine contraction induced by Tanzanian plants used to induce abortion

    Nikolajsen, Tine; Nielsen, Frank; Rasch, Vibeke;

    2011-01-01

    Women in Tanzania use plants to induce abortion. It is not known whether the plants have an effect.......Women in Tanzania use plants to induce abortion. It is not known whether the plants have an effect....

  5. Abortion Rates Rising in Zika-Affected Countries, Study Shows

    ... nlm.nih.gov/medlineplus/news/fullstory_159500.html Abortion Rates Rising in Zika-Affected Countries, Study Shows ... from mosquito-borne Zika may be driving up abortion rates in Latin American countries affected by the ...

  6. Their Right to an Abortion, Your Right to Know

    ... Size Email Print Share Their Right to an Abortion, Your Right to Know Page Content Article Body ... a handful of states grant minors access to abortion without their parents’ knowledge or permission. The majority ...

  7. Pregnancy Choices: Raising the Baby, Adoption, and Abortion

    ... PREGNANCY Pregnancy Choices: Raising the Baby, Adoption, and Abortion • What are my options if I find out ... is financial help available? • If I am considering abortion, what should I know about my state’s laws? • ...

  8. Abortion Rates Rising in Zika-Affected Countries, Study Shows

    ... page: https://medlineplus.gov/news/fullstory_159500.html Abortion Rates Rising in Zika-Affected Countries, Study Shows ... from mosquito-borne Zika may be driving up abortion rates in Latin American countries affected by the ...

  9. Development of abort trigger system for SuperKEKB

    We have developed the new abort trigger system for SuperKEKB. The abort trigger system collects more than 130 abort signals and issues the abort kicker trigger signal. Since the response time of the system is required to be less than 20 μs, the abort signals are transmitted as optical signals. The system also has the timestamp function to record the abort signal received time with a 0.1 μs time resolution. Based on the performance tests, the response time of the modules is considered to be much shorter than cable delay. In the new system, the timestamp information gives the order of the received abort signals. This paper describes the design and the result of the performance test of the new abort trigger system. (author)

  10. Socioeconomic position and the risk of spontaneous abortion

    Norsker, Filippa Nyboe; Espenhain, Laura; A Rogvi, Sofie; Morgen, Camilla Schmidt; Andersen, Per Kragh; Andersen, Anne-Marie Nybo

    2012-01-01

    To investigate the relationship between different indicators of socioeconomic position and the risk of spontaneous abortion.......To investigate the relationship between different indicators of socioeconomic position and the risk of spontaneous abortion....

  11. Induced abortion and placenta complications in the subsequent pregnancy

    Zhou, Wei Jin; Nielsen, Gunnar Lauge; Larsen, Helle; Olsen, Jørn

    2001-01-01

    Background. To study the risk of placenta complications following an induced abortion as a function of the interpregnancy interval. Methods. This study is based on three Danish national registries; the Medical Birth Registry, the Hospital Discharge Registry, and the Induced Abortion Registry. All...... primigravida women from 1980 to 1982 were identified in these three registries. A total of 15,727 women who terminated the pregnancy with a first trimester induced abortion were selected to the abortion cohort, and 46,026 women who did not terminate the pregnancy with an induced abortion constituted the...... Medical Birth Registry records. Results. A slightly higher risk of placenta complications following an abortion was found. Retained placenta occurred more frequently in women with one, two or more previous abortions, compared with women without any previous abortion of similar gravidity. Adjusting for...

  12. Mechanism and role of MCP-1 upregulation upon chikungunya virus infection in human peripheral blood mononuclear cells.

    Ruiz Silva, Mariana; van der Ende-Metselaar, Heidi; Mulder, H Lie; Smit, Jolanda M; Rodenhuis-Zybert, Izabela A

    2016-01-01

    Monocyte chemoattractant protein-1 (MCP-1/CCL2)-mediated migration of monocytes is essential for immunological surveillance of tissues. During chikungunya virus (CHIKV) infection however, excessive production of MCP-1 has been linked to disease pathogenesis. High MCP-1 serum levels are detected during the viremic phase of CHIKV infection and correlate with the virus titre. In vitro CHIKV infection was also shown to stimulate MCP-1 production in whole blood; yet the role and the mechanism of MCP-1 production upon infection of human peripheral blood mononuclear cells remain unknown. Here we found that active CHIKV infection stimulated production of MCP-1 in monocytes. Importantly however, we found that communication with other leukocytes is crucial to yield MCP-1 by monocytes upon CHIKV infection. Indeed, blocking interferon-α/β receptor or the JAK1/JAK2 signalling downstream of the receptor abolished CHIKV-mediated MCP-1 production. Additionally, we show that despite the apparent correlation between IFN type I, CHIKV replication and MCP-1, modulating the levels of the chemokine did not influence CHIKV infection. In summary, our data disclose the complexity of MCP-1 regulation upon CHIKV infection and point to a crucial role of IFNβ in the chemokine secretion. We propose that balance between these soluble factors is imperative for an appropriate host response to CHIKV infection. PMID:27558873

  13. Mechanism and role of MCP-1 upregulation upon chikungunya virus infection in human peripheral blood mononuclear cells

    Ruiz Silva, Mariana; van der Ende-Metselaar, Heidi; Mulder, H. Lie; Smit, Jolanda M.; Rodenhuis-Zybert, Izabela A.

    2016-01-01

    Monocyte chemoattractant protein-1 (MCP-1/CCL2)-mediated migration of monocytes is essential for immunological surveillance of tissues. During chikungunya virus (CHIKV) infection however, excessive production of MCP-1 has been linked to disease pathogenesis. High MCP-1 serum levels are detected during the viremic phase of CHIKV infection and correlate with the virus titre. In vitro CHIKV infection was also shown to stimulate MCP-1 production in whole blood; yet the role and the mechanism of MCP-1 production upon infection of human peripheral blood mononuclear cells remain unknown. Here we found that active CHIKV infection stimulated production of MCP-1 in monocytes. Importantly however, we found that communication with other leukocytes is crucial to yield MCP-1 by monocytes upon CHIKV infection. Indeed, blocking interferon-α/β receptor or the JAK1/JAK2 signalling downstream of the receptor abolished CHIKV-mediated MCP-1 production. Additionally, we show that despite the apparent correlation between IFN type I, CHIKV replication and MCP-1, modulating the levels of the chemokine did not influence CHIKV infection. In summary, our data disclose the complexity of MCP-1 regulation upon CHIKV infection and point to a crucial role of IFNβ in the chemokine secretion. We propose that balance between these soluble factors is imperative for an appropriate host response to CHIKV infection. PMID:27558873

  14. Studies on Expression of IGF-II Gene in Deciduas Derived from Medical Abortion Patients

    2000-01-01

    Objective To determine the effect of insulin-like growth factor-Ⅱ (IGF-Ⅱ ) upon the maintenance of decidua in early pregnancy and its relationship with progesterone, as well as its role in medical abortion. Materials & Methods Decidua tissue was obtained from 28 women who undergoing surgical abortion and 39 for medical abortion respectively at 5~7 weeks of gestation. The extracted total RNA was reversely transcripted and amplified by PCR with spe cific primers (IGF-Ⅱ and β-actin). The products were semi-quantitated by MIAS 300 system and qualitatively analyzed by southern blotting. Results The expression of IGF-Ⅱ gene in decidua from surgical abortion was signif icantly higher than that from medical abortion (P<0.05). The average IGF-Ⅱ gene transcription values were 1. 54±0.79 and 0.72±0.39 respectively. The results of southern blotting proved qualitatively that the RT-PCR products were IGF-Ⅱ cDNA. Conclusion IGF-Ⅱ plays a role in the maintenance of decidua in early pregnancy. It may act as a mediator of progestin. It's also involved in the molecular mechanism of mifepristone.

  15. "The health exception": a means of expanding access to legal abortion.

    González Vélez, Ana Cristina

    2012-12-01

    In most Latin American countries, abortion is not illegal if there is a risk to the life or health of the woman. This article discusses the process of expanding the interpretation of this "health exception" to mean that even the possibility of harm to health should make an abortion legal--which then becomes a mechanism for expanding women's right of access to safe abortion services. The article reports on an assessment of the impact of disseminating information on this interpretation of risk to health in Latin America, and how a regional process of debate and training of health service providers in 2009-10 has influenced the views and practice of health professionals in Argentina, Colombia, Mexico and Peru. The training included human rights arguments for applying the health exception in a comprehensive manner. All the respondents recognized the importance of interpreting risk to health as far more than the risk of death. Data from two clinics in Colombia also show an important increase in the number of women who had a legal abortion following this training. Dissemination of information and training on the health exception must continue--to protect women's right to health, reduce mortality and morbidity among those with unwanted pregnancies and encourage timely access to safe abortion services. PMID:23245405

  16. Catholic options in the abortion debate.

    Maguire, D C

    1990-01-01

    The little-known Roman Catholic theological doctrine of probabilism, an ethical system explicated in all manuals of moral theology, is explained using as an example the dilemma of abortion. Probabilism is based on the notion that a doubtful moral obligation may not be imposed as though it were certain. "Ubi dubium, ibi libertas," means where there is doubt, there is freedom. There are 2 types of moral probability, intrinsic probability, where the individual, without the help of moral theologians, perceives the inapplicability of a particular moral teaching; and extrinsic probability, which involves reliance on the findings of 5 or 6 reputable moral theologians, who may hold a liberal view. Probabilism implies a reasonable doubt, and one's reasons must be cogent, but not necessarily conclusive. Today's abortion debate is an example of a respectable debate, where the liberal view has been endorsed by a number of reputable religious or other humanitarian bodies that in some cases abortion is not always immoral. Other examples in history are the view once taught by the church that taking interest on loans was immoral, that depriving slaves and women of civil rights on non-Catholics of religious or political freedom was moral. For today's legislators, there is a precedent throughout theological history for the state permitting an evil: both St. Augustine and St. Thomas Aquinas wrote that prostitution, although evil, should not be outlawed, because worse evils would occur with prohibition. Legislators who personally find abortion always immoral can support a Roe V. Wade decision because 1) it does not require anyone to have an abortion, and 2) the abortion debate, among Catholics, and non-Catholics is not settled. PMID:12178838

  17. Misoprostol and illegal abortion in Fortaleza, Brazil.

    Coêlho, H L; Teixeira, A C; Santos, A P; Forte, E B; Morais, S M; La Vecchia, C; Tognoni, G; Herxheimer, A

    1993-05-15

    Misoprostol, a prostaglandin E1 analogue indicated for ulcer treatment, has been widely used as an abortifacient by women in Brazil, where abortion is legal only in cases of rape or incest, or to save the woman's life. Because misoprostol is an inefficient abortifacient, many women who use it have incomplete abortions and need uterine evacuation. We reviewed the records of women admitted to the main obstetric hospital of Fortaleza, capital of Ceará state, Brazil, between January, 1990, and July, 1992, for uterine evacuation after induced abortion. The number of incomplete abortions induced by misoprostol increased substantially during the first half of 1990, and declined thereafter. Of the 593 cases in 1991, 75% were related to misoprostol, 10% to the use of other specified drugs, and 6% to unspecified drugs. For the remaining 9% the procedure used was not recorded; these included 3% in whom abortion had been induced by a clandestine abortionist. The number of uterine evacuations per month fell from 89 in August, 1990, to 62 in July, 1991, when sales of misoprostol in Ceará state were suspended. The fall continued after the sale of misoprostol ceased, to about 20 cases in December, 1991; numbers remained around this level until June, 1992, sustained by clandestine sales. The lack of access to contraception is the main reason for the large numbers of unplanned pregnancies and is a major public health issue for Brazilian women. The prohibition of abortion creates a void in which misuse of medicines is one extra complication, mainly because of the poor control of drug marketing. PMID:8098403

  18. Cytokine gene expression at the materno-foetal interface after experimental Neospora caninum infection of heifers at 110 days of gestation.

    Almería, S; Araujo, R N; Darwich, L; Dubey, J P; Gasbarre, L C

    2011-09-01

    Neospora caninum is a major cause of abortion in cattle, but the reasons why only some animals abort remain unclear. The immunological control of the parasite in the placenta or by the foetus could be the key to determining the mechanism of abortion and/or transplacental transmission to the foetus. In this study, cytokine gene expression, analysed by real-time RT-PCR, at the maternal (caruncle) and foetal placenta (cotyledon) of heifers infected at 110 days of gestation by intravenous inoculation of N. caninum tachyzoites was compared with the responses in uninfected heifers. Animals were euthanized 3 weeks after infection. Upregulated Th1, Th2 and T-regulatory (Treg) cytokine gene expression was observed in both the maternal and the foetal placenta in the infected group. In the caruncle of infected animals, the main changes included upregulation of IFN-γ, IL-12p40, IL-6 and IL-10. In the cotyledon, the main changes included upregulation of IFN-γ and downregulation of TGF-β, being the later the only cytokine downregulated in the infected group. The observed cytokine expression pattern was associated with alive but transplacentally infected foetuses, suggesting that such cytokine pattern is beneficial to foetal survival, but could have a role in the transplacental transmission of the parasite. PMID:21711362

  19. Nurses and care of women seeking abortions, 1971 to 2011.

    McLemore, Monica; Levi, Amy

    2011-01-01

    In its first issue in 1972, JOGNN published a review article reporting surveillance data about abortions in the United States (Bourne, Kahn, Conger, & Tyler, 1972). This historical article predated Roe v. Wade, the U.S. Supreme Court decision legalizing abortion. Since this landmark decision, numerous articles have addressed nurses' role in abortion care. We review current literature on nurses and abortion care and use thematic categories to highlight areas of investigation. PMID:22273447

  20. Analysis of the Spontaneous Abortion in Chinese Married Women

    高尔生; 邓新清; 何更生; 方可娟; 唐威; 楼超华

    1994-01-01

    The spontaneous abortion is a common type of pregnant outcomes. The spontaneous abortion rate can be used to indicate the women's fecundity and the level of the reproductive health. It is also a sensitive indicator for determing the social, economic, and health status and prenatal care. To explore the preventive method for spontaneous abortion and improve women's health level, it is important to evaluate the status of spontaneous abortion and to determine the factors affecting

  1. Abortion Costs, Separation and Non-Marital Childbearing

    Andrew Beauchamp

    2012-01-01

    How do abortion costs affect non-marital childbearing? While greater access to abortion has the first-order effect of reducing childbearing among pregnant women, it could nonetheless lead to unintended consequences via effects on marriage market norms. Single motherhood could rise if lower-cost abortion makes it easier for men to avoid marriage. We identify the effect of abortion costs on separation, cohabitation and marriage following a birth by exploiting the "miscarriage-as-a-natural exper...

  2. Effectiveness of Family Planning Policies: The Abortion Paradox

    Nathalie Bajos; Mireille Le Guen; Aline Bohet; Henri Panjo; Caroline Moreau

    2014-01-01

    Objective The relation between levels of contraceptive use and the incidence of induced abortion remains a topic of heated debate. Many of the contradictions are likely due to the fact that abortion is the end point of a process that starts with sexual activity, contraceptive use (or non-use), followed by unwanted pregnancy, a decision to terminate, and access to abortion. Trends in abortion rates reflect changes in each step of this process, and opposing trends may cancel each other out. Thi...

  3. Post-Abortion Syndrome: A Critical Review of the Literature

    Robins, Melanie

    2013-01-01

    Background and Aim Unwanted pregnancy and abortion are common life events, with an estimated 1 in 5 women experiencing an abortion within their lifetime. Although abortion itself is a relatively minor, safe procedure with minimal physical impact, controversy exists regarding the psychological risks associated with the termination of a pregnancy. A key argument within this debate is whether or not there is such a phenomenon as post-abortion syndrome. Therefore, this study aimed to examine t...

  4. Factors affecting attitudes towards medical abortion in Lithuania

    Lazarus, Jeff; Nielsen, Stine; Jakubcionyte, Rita;

    2006-01-01

    Surgical abortion in Lithuania is governed by a 1994 ministerial decree that made it legal for any woman 16 or older. This article seeks to determine the key demographic factors in Lithuanian attitudes towards medical abortion, which is currently not legal.......Surgical abortion in Lithuania is governed by a 1994 ministerial decree that made it legal for any woman 16 or older. This article seeks to determine the key demographic factors in Lithuanian attitudes towards medical abortion, which is currently not legal....

  5. Application of Fault Management Theory to the Quantitative Selection of a Launch Vehicle Abort Trigger Suite

    Lo, Yunnhon; Johnson, Stephen B.; Breckenridge, Jonathan T.

    2014-01-01

    This paper describes the quantitative application of the theory of System Health Management and its operational subset, Fault Management, to the selection of Abort Triggers for a human-rated launch vehicle, the United States' National Aeronautics and Space Administration's (NASA) Space Launch System (SLS). The results demonstrate the efficacy of the theory to assess the effectiveness of candidate failure detection and response mechanisms to protect humans from time-critical and severe hazards. The quantitative method was successfully used on the SLS to aid selection of its suite of Abort Triggers.

  6. [Religion, morality and politics: the abortion debate].

    Ladriere, P

    1982-01-01

    The views of morality enunciated by the Protestant and Catholic churches in the process of France's abortion law revision are examined through an analysis of the testimony of each church and its moral theologians during hearings held from July-November 1973 by the Commission of Cultural, Family, and Social Affairs of the National Assembly concerning the proposed abortion legislation. The offical Catholic Church position, which restated a neoscholastic philosophy with its theory of human nature, natural law, natural right, and natural morality, was opposed by 2 priests who participated as members of other organizations. The moral principles behind the official Catholic position included the sacred and absolute principle of respect for life, the beginning of human life at conception, and the responsibility to protect the fetus as a human being. Internal Catholic challenges to the official position appeared to rest principally on the question of when life begins but also touched on the inappropriateness of viewing unwanted pregnancy as a punishment for sexual activity, the constant recourse to authority of the church, and the reluctance to reexamine questions on new evidence. Faced with the likely replacement of abortion law consistent with Catholic morality by 1 seriously at variance, the French Church and state while justifying their organized opposition to any change. The right of the church to impose its views on the legislature and on society, the view of the cultural context of abortion as a degradation of public attitudes expressed in rejection of children, the necessary connections between sexuality and fertility, the necessity for women to be able to control their fertility if they were to participate fully in society, the debased conditions in which thousands of illegal abortions occurred or the exaggeration of such conditions were other issues. Proposed legislation on abortion was opposed by the official Catholic position, which instead called for a vaguely

  7. Spontaneous abortion and physical strain around implantation

    Hjollund, N H; Jensen, Tina Kold; Bonde, Jens Peter;

    2000-01-01

    Existing studies of physical strain and spontaneous abortion are mainly retrospective or based only on pregnancies that have survived the first trimester. Furthermore, almost all studies have relied on averaged measures of physical strain, which tend to blur an effect if peak values during short...... pregnancy the women recorded physical strain prospectively in a structured diary. Physical strain around the time of implantation was associated with later spontaneous abortion. The adjusted risk ratio for women who reported physical strain higher than average at day 6 to 9 after the estimated date of...

  8. Social forces and the abortion law.

    Francome, Colin

    1980-01-01

    This research analyses the social and political forces underlying the 1aws of abortion in Britain and the United States. It sets out to explain the apparent paradox that the United States now has an abortion law which is more liberal than Britain despite the fact that in many ways it is a more conservative society. Furthemore it aims to set this recent situation in a historical context and to examine recent and likely future developments. It analyses the major social forces on either si...

  9. A comment on Tooley's Abortion and Infanticide.

    Tushnet, Mark; Seidman, Louis Michael

    1986-01-01

    Tushnet and Seidman attempt to show that, even if Michael Tooley is correct that fetuses have no right to life, others may have a right to their continued existence. Rights-bearing third parties with an interest in the fetus might be biological fathers, prospective adoptive parents, or even society as a whole. Criteria for assessing the legitimacy of claims of interest must be developed and then balanced against the claims of those who support abortion. The authors also discuss principles of bodily autonomy, the destruction as well as the removal of the fetus, and the question of whether legislation prohibiting abortion is mandatory, permissible, or optional. PMID:11653692

  10. Acute pancreatitis following medical abortion: Case report

    Amini Hashem

    2004-04-01

    Full Text Available Abstract Background Acute pancreatitis rarely complicates pregnancy. Although most pregnant women with acute pancreatitis have associated gallstones, less common causes such as drugs have been reported. Case presentation We report the case of a 34-year-old woman who underwent medical abortion with mifepristone and gemeprost and received codeine as pain-relief during the induction of abortion. She developed a severe acute necrotizing pancreatitis which required 14 days of intensive care. Other possible etiological factors, i.e. gallstone, alcohol intake and hyperlipidemia, were excluded. Conclusions The reported case of acute pancreatitis was most likely drug-induced.

  11. Susceptibility and Immune Defence Mechanisms of Rhynchophorus ferrugineus (Olivier (Coleoptera: Curculionidae against Entomopathogenic Fungal Infections

    Abid Hussain

    2016-09-01

    Full Text Available Insects infected with entomopathogenic fungi, experience physiological changes that influence their growth and immune defence. The potential of nine isolates of entomopathogenic fungi was evaluated after determining percent germination and relative conidial hydrophobicity. However, nutritional indices were evaluated after immersing eighth-instar Rhynchophorus ferrugineus larvae into each isolate suspension (1 × 107 conidia/mL. The results showed that isolates B6884 and M9374 had 44.51% and 39.02% higher conidial hydrophobicity compared with isolate I03011 (least virulent. The results of nutritional index assays revealed a significant reduction in growth indices after infection with different isolates. Compared with control, B6884 and M9374 greatly decreased larval growth by reducing the efficacy of conversion of ingested food (36%–47% and Efficacy of conversion of digested food (50%–63%. Furthermore, only isolate B6884 induced 100% mortality within 12 days. Compared with control, isolate I03011, possessing the lowest conidial hydrophobicity, only reduced 0.29% of the efficacy of conversion of ingested food (ECI and 0.48% of the efficacy of conversion of digested food (ECD. Similarly, transcriptomic analysis of genes related to the Red palm weevil (RPW immune response, including pathogen recognition receptors (C-type lectin and endo-beta-1,4-glucanse, signal modulator (Serine protease-like protein, signal transductors (Calmodulin-like protein and EF-hand domain containing protein and effectors (C-type lysozyme, Cathepsin L., Defensin-like protein, Serine carboxypeptidase, and Thaumatin-like protein, was significantly increased in larval samples infected with B6884 and M9374. These results suggest that for an isolate to be virulent, conidial hydrophobicity and germination should also be considered during pathogen selection, as these factors could significantly impact host growth and immune defence mechanisms.

  12. Complement inhibitors from scabies mites promote streptococcal growth--a novel mechanism in infected epidermis?

    Angela Mika

    Full Text Available BACKGROUND: Scabies is highly prevalent in socially disadvantaged communities such as indigenous populations and in developing countries. Generalized itching causes discomfort to the patient; however, serious complications can occur as a result of secondary bacterial pyoderma, commonly caused by Streptococcus pyogenes (GAS or Staphylococcus aureus. In the tropics, skin damage due to scabies mite infestations has been postulated to be an important link in the pathogenesis of disease associated with acute rheumatic fever and heart disease, poststreptococcal glomerulonephritis and systemic sepsis. Treatment of scabies decreases the prevalence of infections by bacteria. This study aims to identify the molecular mechanisms underlying the link between scabies and GAS infections. METHODOLOGY/PRINCIPAL FINDINGS: GAS bacteria were pre-incubated with blood containing active complement, phagocytes and antibodies against the bacteria, and subsequently tested for viability by plate counts. Initial experiments were done with serum from an individual previously exposed to GAS with naturally acquired anti-GAS antibodies. The protocol was optimized for large-scale testing of low-opsonic whole blood from non-exposed human donors by supplementing with a standard dose of heat inactivated human sera previously exposed to GAS. This allowed an extension of the dataset to two additional donors and four proteins tested at a range of concentrations. Shown first is the effect of scabies mite complement inhibitors on human complement using ELISA-based complement activation assays. Six purified recombinant mite proteins tested at a concentration of 50 µg/ml blocked all three complement activation pathways. Further we demonstrate in human whole blood assays that each of four scabies mite complement inhibitors tested increased GAS survival rates by 2-15 fold. CONCLUSIONS/SIGNIFICANCE: We propose that local complement inhibition plays an important role in the development of

  13. Evolutionary mechanisms of persistence and diversification of a calicivirus within endemically infected natural host populations.

    Coyne, Karen P; Gaskell, Rosalind M; Dawson, Susan; Porter, Carol J; Radford, Alan D

    2007-02-01

    In order to understand the evolutionary mechanisms of persistence and diversification within the Caliciviridae, we have been exploiting endemic infection of feline calicivirus within five geographically distinct household groups of cats. By sequencing immunodominant and variable regions of the capsid gene, we identified the relative contribution of the different evolutionary processes employed by the virus to ensure its long-term survival in the host population. Such strategies included progressive evolution of a given variant of a strain through mutation accumulation within an individual, sequential reinfection with either a variant of the same strain or with a different strain, and mixed infection. Recombination between different strains in this study has been reported in detail elsewhere (K. P. Coyne et al., J. Gen. Virol. 87:921-926, 2006). Here, we provide evidence to suggest that true long-term persistent infection in individuals is relatively rare, with the majority of apparent viral carriers undergoing a combination of progressive evolution and cyclical reinfection. Progressive evolution at the individual level and variant reinfection at both the individual and population levels were associated with positive selection. Two measures of evolution rate were determined; for a virus progressively evolving within an individual (1.32 x 10(-2) to 2.64 x 10(-2) substitutions per nucleotide per year, i.e., no transmission) and for a strain circulating within a population (3.84 x 10(-2) to 4.56 x 10(-2) substitutions per nucleotide per year, i.e., including transmission). Reiteration of both progressive evolution and variant reinfection appeared to lead to a gradual increase in the diversity of a given strain of virus, both in the individual and in the population, until eventually new strains emerged. PMID:17151126

  14. Molecular Mechanisms of White Spot Syndrome Virus Infection and Perspectives on Treatments.

    Verbruggen, Bas; Bickley, Lisa K; van Aerle, Ronny; Bateman, Kelly S; Stentiford, Grant D; Santos, Eduarda M; Tyler, Charles R

    2016-01-01

    Since its emergence in the 1990s, White Spot Disease (WSD) has had major economic and societal impact in the crustacean aquaculture sector. Over the years shrimp farming alone has experienced billion dollar losses through WSD. The disease is caused by the White Spot Syndrome Virus (WSSV), a large dsDNA virus and the only member of the Nimaviridae family. Susceptibility to WSSV in a wide range of crustacean hosts makes it a major risk factor in the translocation of live animals and in commodity products. Currently there are no effective treatments for this disease. Understanding the molecular basis of disease processes has contributed significantly to the treatment of many human and animal pathogens, and with a similar aim considerable efforts have been directed towards understanding host-pathogen molecular interactions for WSD. Work on the molecular mechanisms of pathogenesis in aquatic crustaceans has been restricted by a lack of sequenced and annotated genomes for host species. Nevertheless, some of the key host-pathogen interactions have been established: between viral envelope proteins and host cell receptors at initiation of infection, involvement of various immune system pathways in response to WSSV, and the roles of various host and virus miRNAs in mitigation or progression of disease. Despite these advances, many fundamental knowledge gaps remain; for example, the roles of the majority of WSSV proteins are still unknown. In this review we assess current knowledge of how WSSV infects and replicates in its host, and critique strategies for WSD treatment. PMID:26797629

  15. Mechanism of infectivity of a murine leukemia virus in adult mice

    Infection of adult BALB/c mice with murine leukemia virus (MuLV) induces typical thymic lymphomas. Expression of virus was measured by using a radioimmunoassay for murine P-30, a virion core protein. Nineteen days after injection of MuLV-S into adult mice, there were 0.3μg P-30/ml of serum. X-irradiation permitted the early expression of high levels of viremia, when given before or after MuLV-S administration, and it also hastened the development of lymphomas. Seventeen to 21 days after injection of MuLV-S into x-irradiated (600 rads) adult mice, there were 2.7 μg of P-30/ml of serum. The virus produced by infected adult mice was infectious and oncogenic when given to newborn mice. Several lines of evidence are presented that suggest the mechanism by which x-irradiation permits early expession of virion proteins and lymphomas is not immunosuppression

  16. Anti-infective mannose receptor immune mechanism in large yellow croaker (Larimichthys crocea).

    Dong, Xiangli; Li, Jiji; He, Jianyu; Liu, Wei; Jiang, Lihua; Ye, Yingying; Wu, Changwen

    2016-07-01

    Mannose receptor (MR) is a pattern recognition receptor (PRR) that plays a significant role in immunity responses. Its role has been described extensively in mammals, but very rarely in fish. Recently, with the rapid development of an aquaculture industry cultivating large yellow croaker (Larimichthys crocea), infectious diseases caused by viruses, bacteria and parasites are becoming more frequent and more severe, in particular bacterial infections caused by Vibrio anguillarum, resulting in great economical losses. Extensive use of antibiotics as conventional treatment has led to microenvironment imbalances, development of drug-resistant bacteria and deposition of drug residues, which cause environmental pollution and ultimately affect human health. The purpose of this pilot study was to detect the transcriptional levels of C-type mannose receptor genes MRC1 (4710-bp ORF; encoding 1437 aa; a signal peptide, a SMART RICIN domain, a SMART FN2 domain, eight SMART CLECT domain, and a transmembrane helix region) and MRC2 (3996-bp ORF; encoding 1484 aa; a SMART FN2 domain, eight SMART CLECT domains, and a transmembrane region) in the liver, kidney and spleen tissues of L. crocea challenged by V. anguillarum, to explore the effective domain and the molecular response mechanisms of MRC1 and MRC2, and, ultimately, to explore the possibility of developing a vaccine targeting V. anguillarum infections. PMID:27071518

  17. Molecular Mechanisms of White Spot Syndrome Virus Infection and Perspectives on Treatments

    Bas Verbruggen

    2016-01-01

    Full Text Available Since its emergence in the 1990s, White Spot Disease (WSD has had major economic and societal impact in the crustacean aquaculture sector. Over the years shrimp farming alone has experienced billion dollar losses through WSD. The disease is caused by the White Spot Syndrome Virus (WSSV, a large dsDNA virus and the only member of the Nimaviridae family. Susceptibility to WSSV in a wide range of crustacean hosts makes it a major risk factor in the translocation of live animals and in commodity products. Currently there are no effective treatments for this disease. Understanding the molecular basis of disease processes has contributed significantly to the treatment of many human and animal pathogens, and with a similar aim considerable efforts have been directed towards understanding host–pathogen molecular interactions for WSD. Work on the molecular mechanisms of pathogenesis in aquatic crustaceans has been restricted by a lack of sequenced and annotated genomes for host species. Nevertheless, some of the key host–pathogen interactions have been established: between viral envelope proteins and host cell receptors at initiation of infection, involvement of various immune system pathways in response to WSSV, and the roles of various host and virus miRNAs in mitigation or progression of disease. Despite these advances, many fundamental knowledge gaps remain; for example, the roles of the majority of WSSV proteins are still unknown. In this review we assess current knowledge of how WSSV infects and replicates in its host, and critique strategies for WSD treatment.

  18. Acceptance and use of the female condom among women with incomplete abortion in rural Tanzania

    Rasch, Vibeke; Yambesi, Fortunata; Kipingili, Rose

    2006-01-01

    BACKGROUND: This study describes the outcome of a postabortion care intervention aimed at introducing the female condom as a means of preventing women from having unwanted pregnancies and sexually transmitted infections (STIs)/HIV. METHODS: Postabortion contraceptive counseling and services were...... intended to use it again. CONCLUSION: Postabortion care programs provide an excellent entry point for introducing the female condom as a contraceptive method for the prevention of both repeat unwanted pregnancies and STI/HIV infection....... offered to 548 women admitted to the Kagera Regional Hospital for incomplete abortion. The counseling included information about STI/HIV and the use male or female condom. In total, 521 (95%) women accepted contraception. RESULTS: Contraceptive use was assessed 3 months after abortion among 475 (91...

  19. Tricuspid Valve Endocarditis With Group B Streptococcus After an Elective Abortion: The Need for New Data

    Erica E. Palys

    2006-01-01

    Full Text Available Streptococcus agalactiae, commonly known as Group B streptococcus (GBS, was originally discovered as a cause of bovine mastitis. GBS colonizes the genital tract of up to 40% of women and has become a major pathogen in neonatal meningitis. GBS endocarditis is thought to be an uncommon manifestation of this infection and carries a higher mortality compared to other streptococcal pathogens. Studies have shown that endocarditis after abortion has an incidence of about one per million. However, this figure was published prior to routine use of echocardiography for diagnosis. The American Heart Association has recently declared transesophageal echocardiography the gold standard for endocarditis diagnosis. This case report illustrates that, given the potentially devastating consequences of endocarditis, there is a need for updated studies to adequately assess the true incidence of this infection. Pending the outcome of these studies, routine GBS screening and prophylactic antibiotics prior to abortion should be recommended.

  20. 21 CFR 884.5070 - Vacuum abortion system.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Vacuum abortion system. 884.5070 Section 884.5070 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... § 884.5070 Vacuum abortion system. (a) Identification. A vacuum abortion system is a device designed...

  1. ANTISPERM ANTIBODY IS A POSSIBLE CAUSE OF SPONTANEOUS ABORTION

    XUChong; CHENFu; LIULi; ZHAOFei-Sha

    1989-01-01

    To clarify the possible correlation between antisperm antibodies (ASA) and spontaneous abortion, 68 women, aged 23-37, experienced 2-9 times of spontaneous abortion were tested for ASA by ELISA. 38 fertile women, aged 24-40, without history of abortion were employed as control.

  2. 42 CFR 457.475 - Limitations on coverage: Abortions.

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Limitations on coverage: Abortions. 457.475 Section... State Plan Requirements: Coverage and Benefits § 457.475 Limitations on coverage: Abortions. (a) General rule. FFP under title XXI is not available in expenditures for an abortion, or in expenditures for...

  3. The Effect of Religious Membership on Teen Abortion Rates.

    Tomal, Annette

    2001-01-01

    Studied abortion rates among teenagers in 1,024 counties in 18 states that report abortion numbers. Results show that counties with high levels of religious membership were more likely to be in a state with a parental involvement law for teenage abortions. Both religious membership level and a parental involvement law were negatively related to…

  4. The Psychosocial Factors of the Abortion Experience: A Critical Review

    Shusterman, Lisa Roseman

    1976-01-01

    Due to faulty methodology no general statements can be made about psychosocial factors for women receiving illegal abortions. Women receiving therapeutic abortions experienced favorable psychological consequences more often than negative consequences. New abortion patients are mostly young, unmarried women who are not in a social position to care…

  5. Interplay between Bladder Microbiota and Urinary Antimicrobial Peptides: Mechanisms for Human Urinary Tract Infection Risk and Symptom Severity

    Nienhouse, Vanessa; Gao, Xiang; Dong, Qunfeng; Nelson, David E; Toh, Evelyn; McKinley, Kathleen; Schreckenberger, Paul; Shibata, Noriko; Cynthia S Fok; Mueller, Elizabeth R.; Brubaker, Linda; Wolfe, Alan J.; Katherine A Radek

    2014-01-01

    Resident bacterial communities (microbiota) and host antimicrobial peptides (AMPs) are both essential components of normal host innate immune responses that limit infection and pathogen induced inflammation. However, their interdependence has not been investigated in the context of urinary tract infection (UTI) susceptibility. Here, we explored the interrelationship between the urinary microbiota and host AMP responses as mechanisms for UTI risk. Using prospectively collected day of surgery (...

  6. Importance of Bacterial Replication and Alveolar Macrophage-Independent Clearance Mechanisms during Early Lung Infection with Streptococcus pneumoniae

    Camberlein, Emilie; Cohen, Jonathan M.; José, Ricardo; Hyams, Catherine J.; Callard, Robin; Chimalapati, Suneeta; Yuste, Jose; Edwards, Lindsey A.; Marshall, Helina; van Rooijen, Nico; Noursadeghi, Mahdad; Brown, Jeremy S.

    2015-01-01

    Although the importance of alveolar macrophages for host immunity during early Streptococcus pneumoniae lung infection is well established, the contribution and relative importance of other innate immunity mechanisms and of bacterial factors are less clear. We have used a murine model of S. pneumoniae early lung infection with wild-type, unencapsulated, and para-amino benzoic acid auxotroph mutant TIGR4 strains to assess the effects of inoculum size, bacterial replication, capsule, and alveol...

  7. C. elegans germline-deficient mutants respond to pathogen infection using shared and distinct mechanisms.

    Michael TeKippe

    Full Text Available Reproduction extracts a cost in resources that organisms are then unable to utilize to deal with a multitude of environmental stressors. In the nematode C. elegans, development of the germline shortens the lifespan of the animal and increases its susceptibility to microbial pathogens. Prior studies have demonstrated germline-deficient nematodes to have increased resistance to gram negative bacteria. We show that germline-deficient strains display increased resistance across a broad range of pathogens including gram positive and gram negative bacteria, and the fungal pathogen Cryptococcus neoformans. Furthermore, we show that the FOXO transcription factor DAF-16, which regulates longevity and immunity in C. elegans, appears to be crucial for maintaining longevity in both wild-type and germline-deficient backgrounds. Our studies indicate that germline-deficient mutants glp-1 and glp-4 respond to pathogen infection using common and different mechanisms that involve the activation of DAF-16.

  8. Mechanisms of Multi-strain Coexistence in Host-Phage Systems with Nested Infection Networks

    Jover, Luis F.; Cortez, Michael H.; Weitz, Joshua S.

    2013-01-01

    Bacteria and their viruses ("bacteriophages") coexist in natural environments forming complex infection networks. Recent empirical findings suggest that phage-bacteria infection networks often possess a nested structure such that there is a hierarchical relationship among who can infect whom. Here we consider how nested infection networks may affect phage and bacteria dynamics using a multi-type Lotka-Volterra framework with cross-infection. Analysis of similar models have, in the past, assum...

  9. Candida parapsilosis Resistance to Fluconazole: Molecular Mechanisms and In Vivo Impact in Infected Galleria mellonella Larvae.

    Souza, Ana Carolina R; Fuchs, Beth Burgwyn; Pinhati, Henrique M S; Siqueira, Ricardo A; Hagen, Ferry; Meis, Jacques F; Mylonakis, Eleftherios; Colombo, Arnaldo L

    2015-10-01

    Candida parapsilosis is the main non-albicans Candida species isolated from patients in Latin America. Mutations in the ERG11 gene and overexpression of membrane transporter proteins have been linked to fluconazole resistance. The aim of this study was to evaluate the molecular mechanisms in fluconazole-resistant strains of C. parapsilosis isolated from critically ill patients. The identities of the nine collected C. parapsilosis isolates at the species level were confirmed through molecular identification with a TaqMan qPCR assay. The clonal origin of the strains was checked by microsatellite typing. The Galleria mellonella infection model was used to confirm in vitro resistance. We assessed the presence of ERG11 mutations, as well as the expression of ERG11 and two additional genes that contribute to antifungal resistance (CDR1 and MDR1), by using real-time quantitative PCR. All of the C. parapsilosis (sensu stricto) isolates tested exhibited fluconazole MICs between 8 and 16 μg/ml. The in vitro data were confirmed by the failure of fluconazole in the treatment of G. mellonella infected with fluconazole-resistant strains of C. parapsilosis. Sequencing of the ERG11 gene revealed a common mutation leading to a Y132F amino acid substitution in all of the isolates, a finding consistent with their clonal origin. After fluconazole exposure, overexpression was noted for ERG11, CDR1, and MDR1 in 9/9, 9/9, and 2/9 strains, respectively. We demonstrated that a combination of molecular mechanisms, including the presence of point mutations in the ERG11 gene, overexpression of ERG11, and genes encoding efflux pumps, are involved in fluconazole resistance in C. parapsilosis. PMID:26259795

  10. Knowledge Level of Gynecologists and Midwives of Yazd Concerning Rules and Regulations of Therapeutic Abortion(Legal) and Criminal Abortion

    M Ghadipasha; N BASHARDOOST; A Ghodoosi; B Samadirad; Nikian, Y.; Roohparvar, R.

    2011-01-01

    Introduction: Abortion has always been a controversial issue and all religions, humanistic and medical communities have opposed it . The complications of illegal abortion are one of the most common reasons of hospital admission in developing countries. W.H.O estimates that the one eight of all pregnancy deaths is due to illegal abortion. Lack of knowledge of the medical team about the abortion regulations and rules can endanger the pregnant mothers life and also create certain problems for me...

  11. Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. V. Anamnestic cellular and humoral responses following challenge infection

    Correa-Oliveira, R.; Sher, A.; James, S.L.

    1984-03-01

    Mice vaccinated with radiation-attenuated cercariae display low levels of cellular and humoral immune responses toward schistosomulum antigens, as measured in vitro by lymphocyte blastogenesis and quantitation of anti-larval antibodies by indirect immunofluorescence. Both responses wane with time after vaccination. However subsequent challenge infection provokes immune responses of classical anamnestic character, being both more rapid in appearance and of greater magnitude. Antigen responsive cells appear in lymph nodes draining the challenge site within 24 hours after infection. Both circulating anti-schistosomulum surface antibodies as well as cytophilic IgE anti-worm antigen antibodies increase substantially by 1 week after challenge. All of the anamnestic circulating antibodies belong to the IgG class. Those findings support the concept that vaccine-induced resistance to Schistosoma mansoni infection involves sensitized T and B lymphocytes, and point to the possible role of post-challenge anamnestic responses in the effector mechanism of parasite killing in this model.

  12. Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. V. Anamnestic cellular and humoral responses following challenge infection

    Mice vaccinated with radiation-attenuated cercariae display low levels of cellular and humoral immune responses toward schistosomulum antigens, as measured in vitro by lymphocyte blastogenesis and quantitation of anti-larval antibodies by indirect immunofluorescence. Both responses wane with time after vaccination. However subsequent challenge infection provokes immune responses of classical anamnestic character, being both more rapid in appearance and of greater magnitude. Antigen responsive cells appear in lymph nodes draining the challenge site within 24 hours after infection. Both circulating anti-schistosomulum surface antibodies as well as cytophilic IgE anti-worm antigen antibodies increase substantially by 1 week after challenge. All of the anamnestic circulating antibodies belong to the IgG class. Those findings support the concept that vaccine-induced resistance to Schistosoma mansoni infection involves sensitized T and B lymphocytes, and point to the possible role of post-challenge anamnestic responses in the effector mechanism of parasite killing in this model

  13. Do Laws Requiring Parental Involvement to Obtain an Abortion Help Reduce STIs Among Minors

    Silvie Colman; Ted Joyce; Thomas Dee

    2011-01-01

    This issue brief evaluates whether policies requiring parental involvement in minors' decision to obtain an abortion can alter their sexual behavior and help reduce the rates of sexually transmitted infections (STIs) among teens. Using data from the STI surveillance system of the Centers for Disease Control and Prevention on cases of gonorrhea and chlamydia, the findings offer little evidence of a link between parental involvement laws and teen STI rates.

  14. Outbreak of Salmonella Dublin-associated abortion in Danish fur farms

    Dietz, Hans Henrik; Chriél, Mariann; Andersen, Thomas Holmen; Jørgensen, Jens Christian; Torpdahl, Mia; Pedersen, Hans; Pedersen, Karl

    2006-01-01

    Outbreaks of Salmonella Dublin infections were recorded in 25 Danish mink and fox farms. All farms suffered extensive disease problems; clinical and pathological observations included abortion, stillbirths, necrotizing endometritis, and increased mortality. By genotyping with pulsed-field gel electrophoresis and amplified fragment length polymorphism, all isolates of S. Dublin had indistinguishable patterns. The outbreaks took place during April and May, around the time of whelping. During th...

  15. Prevalence and diversity of Arcobacter spp. isolated from the internal organs of spontaneous porcine abortions in Denmark

    On, Stephen L.W.; Jensen, Tim Kåre; Bille-Hansen, Vivi;

    2002-01-01

    pathogens (Brucella, Leptospira, PPV PRRSV), but Arcobacter spp, were recovered from 23/55 abortions. Co-infections with Streptococcus suis, Escherichia coli, and haemolytic streptococci were observed in 7/23 Arcobacter-positive fetuses, and in 4/32 Arcobacter-negative fetuses, Histopathological analyses...

  16. Epizootiologic investigations of selected abortive agents in free-ranging Alpine ibex (Capra ibex ibex) in Switzerland.

    Marreros, Nelson; Hüssy, Daniela; Albini, Sarah; Frey, Caroline F; Abril, Carlos; Vogt, Hans-Rudolf; Holzwarth, Nathalie; Wirz-Dittus, Sophie; Friess, Martina; Engels, Monika; Borel, Nicole; Willisch, Christian S; Signer, Claudio; Hoelzle, Ludwig E; Ryser-Degiorgis, Marie-Pierre

    2011-07-01

    In the early 2000s, several colonies of Alpine ibex (Capra ibex ibex) in Switzerland ceased growing or began to decrease. Reproductive problems due to infections with abortive agents might have negatively affected recruitment. We assessed the presence of selected agents of abortion in Alpine ibex by serologic, molecular, and culture techniques and evaluated whether infection with these agents might have affected population densities. Blood and fecal samples were collected from 651 ibex in 14 colonies throughout the Swiss Alps between 2006 and 2008. All samples were negative for Salmonella spp., Neospora caninum, and Bovine Herpesvirus-1. Antibodies to Coxiella burnetii, Leptospira spp., Chlamydophila abortus, Toxoplasma gondii, and Bovine Viral Diarrhea virus were detected in at least one ibex. Positive serologic results for Brucella spp. likely were false. Overall, 73 samples (11.2%) were antibody-positive for at least one abortive agent. Prevalence was highest for Leptospira spp. (7.9%, 95% CI=5.0-11.7). The low prevalences and the absence of significant differences between colonies with opposite population trends suggest these pathogens do not play a significant role in the population dynamics of Swiss ibex. Alpine ibex do not seem to be a reservoir for these abortive agents or an important source of infection for domestic livestock in Switzerland. Finally, although interactions on summer pastures occur frequently, spillover from infected livestock to free-ranging ibex apparently is uncommon. PMID:21719818

  17. Spiral kicker for the beam abort system

    Martin, R.L.

    1983-01-01

    A brief study was carried out to determine the feasibility of a special kicker to produce a damped spiral beam at the beam dump for the beam abort system. There appears to be no problem with realizing this concept at a reasonably low cost.

  18. Abortion Legalization and Life-Cycle Fertility

    Ananat, Elizabeth Oltmans; Gruber, Jonathan; Levine, Phillip

    2007-01-01

    The early-1970s abortion legalization led to a significant drop in fertility. We investigate whether this decline represented a delay in births or a permanent reduction in fertility. We combine Census and Vital Statistics data to compare the lifetime fertility of women born in early-legalizing states, whose peak childbearing years occurred in the…

  19. Debate: Should Abortion Be Available on Request?

    Nathanson, Bernard; Lawrence, George

    1971-01-01

    Two physicians debate whether abortions should be available on request regardless of medical indications. The crux of the issue is whether the fetus should be considered body tissue over which the woman has complete control or whether society has an interest in the embryo and should protect it. (Author/BY)

  20. [Putting decriminalization of abortion to a refendum].

    1997-09-01

    Surveys conducted in Mexico by GIRE in 1992, 1994, and 1995 reveal that over 80% of the national population believes only a woman or a woman and her partner should make abortion decisions. Neither the government, the Church, nor physicians should intervene. Public opinion and the documented social and public health consequences of illegal abortion demonstrate the obsolescence of laws penalizing abortion. Mexico does not have a direct means of converting the opinions of the population into votes and laws. In place of referendums, committees of specialists have been convened; they are limited in number and ability to represent diverse groups, and oriented above all to the losses and gains of political and parliamentary disputes. The electoral reform of 1995-96 was a good example of the question under debate getting lost in partisan maneuvering. The Federal District and four states have initiated development of the referendum process, but the procedures have been too cumbersome and the results disappointing. In the current day, opinions are often formed not by following a rational process, but by bombardment with advertising appealing to irrational emotions. The democratic effects of referendum should be furthered by guaranteeing fair and exhaustive exposure of all points of view before the vote is held. GIRE recommends that a referendum on decriminalization of abortion should be preceded by a period of at least two years for public debate and reflection, and that the Federal Electoral Institute should organize the debate and the referendum. PMID:12349540

  1. [Social hygiene aspects of abortion in Odessa].

    Zakharchenko, E M; Popov, V E

    1988-02-01

    The birth rate is a major concern in contemporary society today. Socialist countries having the material wherewithal and cultural wealth to maintain their populations have a genuine interest in population growth and maternity is therefore encouraged. The decision to have children lies with each individual family and does not involve society directly, except for the significant number of women who regulate their family size by having an abortion. In connection with the severity of such an intervention, a study of social and hygienic aspects of induced abortion was conducted in Odessa. The information was gathered anonymously among women who came to the gynecological department of a city hospital. 6.1% of the women were under age 20 and this figure may increase in the future. In the U.S. that figure already constitutes 1/3 of all abortions. 47.5% said they had had 3 previous abortions. 13.4% had no children, and 48.8% had 1 child. None of the women with no children thought of that as being the ideal. As reason for the abortion 31.7% gave irregular housing and living conditions, 12.2% unsatisfactory material well-being, 17.1% health reasons, 7.3% enough children already in the family, and 7.3% sickness of children and husband. In 24.4% of cases the husband was indifferent, and in 35.4% insisted on, and in 40.1% was against the woman having an abortion. 60% were thus probably poorly informed about the harmfulness of the operation. 39% of women did not use any contraception. Only 20% had received any information regarding contraceptives. Only 1/3 of obstetricians regularly instruct their patients about the use of contraceptives. Half of the nurses do not touch upon the subject due to lack of time and since instruction in birth control methods is not considered obligatory. Nevertheless it is important for women's health that during clinical examinations risk factors of abortion and the purposefulness of contraception are pointed out. PMID:3367727

  2. Review on abort trajectory for manned lunar landing mission

    2010-01-01

    Abort trajectory is a passage that ensures the astronauts to return safely to the earth when an emergency occurs. Firstly,the essential elements of mission abort are analyzed entirely based on summarizing the existing studies. Then,abort trajectory requirement and rational selection for different flight phases of typical manned lunar mission are discussed specifically. Considering a trade-off between the two primary constrains of an abort,the return time of flight and energy requirement,a general optimizing method for mission abort is proposed. Finally,some suggestions are given for China’s future manned lunar landing mission.

  3. Legal abortions among teenagers in Canada, 1974 through 1978.

    Wadhera, A.; Nair, C.(Argonne National Laboratory, Argonne, IL, 60439, USA)

    1980-01-01

    Between August 1969, when the amendment to the Criminal Code went into effect, and December 1978 about 397 000 legal abortions were performed in hospitals with therapeutic abortion committees in Canada. During the 5-year period 1974-78 abortions in females under 20 years of age accounted for 30.9% of all the legal abortions performed in Canada on Canadian residents, and the abortion rate per 1000 women aged 15 to 19 years increased from 13.6 to 16.3. During 1974-77 the proportion of women in ...

  4. Visualising abortion: emotion discourse and fetal imagery in a contemporary abortion debate.

    Hopkins, Nick; Zeedyk, Suzanne; Raitt, Fiona

    2005-07-01

    This paper presents an analysis of a recent UK anti-abortion campaign in which the use of fetal imagery--especially images of fetal remains--was a prominent issue. A striking feature of the texts produced by the group behind the campaign was the emphasis given to the emotions of those viewing such imagery. Traditionally, social scientific analyses of mass communication have problematised references to emotion and viewed them as being of significance because of their power to subvert the rational appraisal of message content. However, we argue that emotion discourse may be analysed from a different perspective. As the categorisation of the fetus is a social choice and contested, it follows that all protagonists in the abortion debate (whether pro- or anti-abortion) are faced with the task of constructing the fetus as a particular entity rather than another, and that they must seek to portray their preferred categorisation as objective and driven by an 'out-there' reality. Following this logic, we show how the emotional experience of viewing fetal imagery was represented so as to ground an anti-abortion construction of the fetus as objective. We also show how the arguments of the (pro-abortion) opposition were construed as totally discrepant with such emotions and so were invalidated as deceitful distortions of reality. The wider significance of this analysis for social scientific analyses of the abortion debate is discussed. PMID:15893054

  5. Psychology Consequences of Abortion Among The Post Abortion Care Seeking Women in Tehran

    Abolghasem Pourreza

    2011-01-01

    Full Text Available "nObjective: abortion either medical or criminal has distinctive physical, social, and psychological side effects. Detecting types and frequent psychological side effects of abortion among post abortion care seeking women in Tehran was the main objective of the present study. "n Method: 278 women of reproductive age (15-49 interviewed as study population. Response rate was 93/8. Data collected through a questionnaire with 2 parts meeting broad socio-economic characteristics of the respondents and health- related abortion consequences. Tehran hospitals were the site of study. "nResults: The results revealed that at least one-third of the respondents have experienced psychological side effects. Depression, worrying about not being able to conceive again and abnormal eating behaviors were reported as dominant psychological consequences of abortion among the respondents. Decreased self-esteem, nightmare, guilt, and regret with 43.7%, 39.5%, 37.5%, and 33.3% prevalence rates have been placed in the lower status, respectively. "nConclusion: Psychological consequences of abortion have considerably been neglected. Several barriers made findings limited. Different types of psychological side effects, however, experienced by the study population require more intensive attention because of chronic characteristic of psychological disorders, and women's health impact on family and population health.

  6. Establishment of Chronic Infection: Brucella's Stealth Strategy.

    Ahmed, Waqas; Zheng, Ke; Liu, Zheng-Fei

    2016-01-01

    Brucella is a facultative intracellular pathogen that causes zoonotic infection known as brucellosis which results in abortion and infertility in natural host. Humans, especially in low income countries, can acquire infection by direct contact with infected animal or by consumption of animal products and show high morbidity, severe economic losses and public health problems. However for survival, host cells develop complex immune mechanisms to defeat and battle against attacking pathogens and maintain a balance between host resistance and Brucella virulence. On the other hand as a successful intracellular pathogen, Brucella has evolved multiple strategies to evade immune response mechanisms to establish persistent infection and replication within host. In this review, we mainly summarize the "Stealth" strategies employed by Brucella to modulate innate and the adaptive immune systems, autophagy, apoptosis and possible role of small noncoding RNA in the establishment of chronic infection. The purpose of this review is to give an overview for recent understanding how this pathogen evades immune response mechanisms of host, which will facilitate to understanding the pathogenesis of brucellosis and the development of novel, more effective therapeutic approaches to treat brucellosis. PMID:27014640

  7. Molecular Mechanism of Gastric Carcinogenesis in Helicobacter pylori-Infected Rodent Models

    Takeshi Toyoda

    2014-06-01

    Full Text Available Since the discovery of Helicobacter pylori (H. pylori, many efforts have been made to establish animal models for the investigation of the pathological features and molecular mechanisms of gastric carcinogenesis. Among the animal models, Mongolian gerbils and mice are particularly useful for the analysis of H. pylori-associated inflammatory reactions and gastric cancer development. Inhibitors of oxidative stress, cyclooxygenase-2 (COX-2 and nuclear factor-κB, exert preventive effects on chronic gastritis and the development of adenocarcinomas in H. pylori-infected gerbils. Genetically-modified mouse models, including transgenic and knockout mice, have also revealed the importance of p53, COX-2/prostaglandin, Wnt/β-catenin, proinflammatory cytokines, gastrin and type III mucin in the molecular mechanisms of gastric carcinogenesis. Microarray technology is available for comprehensive gene analysis in the gastric mucosa of mouse models, and epigenetics, such as DNA methylation, could be an alternative approach to correlate the observations in animal models with the etiology in humans.

  8. Herbal infusions used for induced abortion.

    Ciganda, Carmen; Laborde, Amalia

    2003-01-01

    Plants and herbs have been used to induce abortions but there is very little published information describing the commonly used ones. The purpose of this report is to describe the herbal products used to induce abortions, and to enhance awareness and understanding of their toxic effects. A descriptive retrospective survey was conducted on the calls received by the Montevideo Poison Centre between 1986 and 1999 concerning the ingestion of herbal infusions with abortive intent. A total of 86 cases involving 30 different plant species were identified. The species most frequently involved were ruda (Ruta chalepensis/graveolens), cola de quirquincho (Lycopodium saururus), parsley (Petroselinum hortense), and an over-the-counter herbal product named Carachipita. The components of Carachipita are pennyroyal (Mentha pulegium), yerba de la perdiz (Margiricarpus pinnatus), oregano (Origanum vulgare), and guaycuri (Statice brasiliensis). Abortion occurred in 23 cases after the ingestion of parsley, ruda, Carachipita, celery, Cedron, francisco alvarez, floripon, espina colorada. Out of the 23 cases, 15 involved the only the ingestion of plants, 4 cases used injected drugs (presumably hormones), and in 4 cases there was associated self-inflicted instrumental manipulation. Multiple organ system failure occurred in those patients who had ingested ruda (alone or in combination with parsley or fennel), Carachipita, arnica, or bardana. Deaths occurred in one case of Carachipita ingestion and in 4 cases of ruda ingestion (2 cases of ruda alone, 2 cases of ruda with parsley and fennel). Self-inflicted instrumental manipulations were found in 4 of the patients with multiple organ system failure and in one of those who died. The results of this report are not conclusive, but it appears that the ingestion of plants to induce abortion involves the risk of severe morbidity and mortality. PMID:12807304

  9. Co-infection by porcine circovirus type 2 and porcine parvovirus in aborted fetuses and stillborn piglets in southern Brazil Co-infecção por circovírus suíno tipo 2 e parvo-vírus suíno em fetos abortados e natimortos suínos no Sul do Brasil

    Caroline A. Pescador

    2007-10-01

    Full Text Available Porcine circovirus types 1 and 2 (PCV1, PCV2 and porcine parvovirus (PPV are widespread in pig populations around the world. Nevertheless, only PCV2 has been associated with different clinical syndromes, thus representing a major problem to the pig industry. The association of cases of swine abortions and stillborns with PCV1 and PCV2 and PPV was studied retrospectively (2005-2007. Additional pathogens were also investigated in lesioned fetuses. The studied litters included stillborn piglets and several mummified fetuses of varied sizes. Ventricular dilatation, myocardial pale areas, and mesocolic edema were the gross lesions. Escherichia coli was detected as co-infecting with PCV2 the cases in which mesocolic edema was seen. Microscopic lesions included non-suppurative myocarditis, myocardial necrosis and fibrosis, mineralization foci and intranuclear inclusion bodies in cardiomyocytes, and interstitial mononuclear pneumonia. Samples from 7 (5.78 per cent of 121 aborted fetuses and stillborn piglets had lesions consistent with a viral cause and showed both positive anti-PCV2 immunostaining as well as PCV2-PCR. In samples from 3 (2.47 per cent of these 7 fetuses, co-infection with PPV was confirmed by Nested-PCR. Both viruses were detected in fetuses at different stages of gestation. Viral antigens of PCV2 were detected by immunohistochemistry mainly in macrophages and myocytes. PCV1 individually was not detected in any of these affected fetuses, but it was associated with PCV2 and/or PPV in some of them. These findings indicate that PCV2 alone or in association with PPV should be kept in mind when investigating causes of infectious abortion in pigs in Brazil.Estudou-se retrospectivamente (2005-2007 a associação de casos de abortos e natimortos suínos com infecções por circovírus suíno (PCV tipos 1 e 2 e parvovírus suíno (PPV. Outros agentes patogênicos foram pesquisados em amostras de fetos com lesões. O estudo incluiu natimortos e

  10. Immunological elimination of infected cells as the candidate mechanism for tumor protection in polyomavirus-infected mice.

    Wirth, J J; Fluck, M M

    1991-01-01

    The uniformly lethal development of mammary tumors in polyomavirus-infected adult female nude mice was prevented by adoptive cell transfer of polyomavirus-immune splenocytes or peritoneal cells. Transferred immune cells also lowered the growth rate of emerging tumors. The induction of other relatively less frequent tumors of the skin and bone was decreased as well. Using in situ hybridization of whole-body sections as well as hybridization of nucleic acids from the mammary glands, we show for...

  11. [Induced abortions in the Third Reich. Legal basis and provision].

    Link, G

    2000-01-01

    This article analyses, after introductory comments on the legal situation in the German Empire and the Weimar Republic, the legal basis for induced abortions during National Socialist rule in Germany. During this period the first legal definition for eugenically and medically indicated abortions was established. At the same time the prohibition of induced abortions outside these criteria was controlled more strictly and violations were punished more severely. This concerned abortions mainly for social reasons. The intention was to legalize abortion for those deemed "less worthy" while, at the same time, to minimise the number of abortions of those considered as "more valuable" to society. The main thrust of this policy was to increase the birth rate of "valuable" citizens. The second part of this paper focuses on eugenic and medical abortions at the University of Freiburg's Maternity Hospital. PMID:11050762

  12. Eliminating the phrase "elective abortion": why language matters.

    Janiak, Elizabeth; Goldberg, Alisa B

    2016-02-01

    The phrase "elective abortion" is often used to describe induced abortions performed for reasons other than a direct, immediate threat to maternal physical health. We argue that the term "elective abortion" is variably defined, misrepresents the complexity and multiplicity of indications for abortion and perpetuates stigma. In practice, restricting access to abortion at the legal, regulatory or institutional level based on subjective perceptions of patient need constrains health care providers' ability to act according to their best clinical judgments and limits patient access to care. The phrase "elective abortion" should be eliminated from scientific and medical discourse to prevent further damage to the public understanding of the variety of indications for which women require expeditious and equitable access to induced abortion. PMID:26480889

  13. Mechanisms and significance of liver steatosis in hepatitis C virus infection

    Francesco Negro

    2006-01-01

    The pathogenesis of liver damage associated with chronic hepatitis C virus (HCV) infection is thought to be largely immunomediated.However,some frequent histopathological features,such as steatosis,suggest a direct cytopathic effect of HCV.The direct responsibility of HCV in the pathogenesis of steatosis is shown by:(1) the association with HCV genotype 3 infection,suggesting that some viral sequences are involved in the intracellular accumulation of lipids;(2) the correlation between severity of steatosis and HCV replication levels; (3) association between response to treatment and disappearance of steatosis. Experimental studies have shown that the nucleocapsid protein of HCV (core protein) is capable and sufficient to induce lipid accumulation in hepatocytes.Moreover, the observation that chronic hepatitis C patients have reduced serum levels of ApoB suggests an interference with the very-low density lipoprotein (VLDL) assembly, although other mechanisms are possible. In patients with sustained virological response induced by antiviral therapy, such levels are normalized. Other observations suggest that the pathogenesis of steatosis in chronic hepatitis C is not solely due to HCV. The origin of the mild steatosis observed in most patients may be metabolic, since its severity correlates with body mass index and insulin resistance. Most studies have shown a correlation between presence and/or severity of steatosis and fibrosis stage, but it is unclear whether this effect is direct or mediated by the associated insulin resistance,increased susceptibility to apoptosis, or by inflammatory cytokines. Finally, steatosis negatively influences the rate of response to antiviral treatment, as confirmed by large clinical trials. Management of steatosis in chronic hepatitis C requires knowledge of its pathogenesis and may involve both life-style changes and pharmacological interventions, although the latter remain largely experimental.

  14. Physician provision of abortion before Roe v. Wade.

    Joffe, C

    1991-01-01

    With the possibility of the Supreme Court overturning the landmark Roe v. Wade (1973) case legalizing abortion, a review of abortion practices pre-Roe is instructive. Abortion became criminalized in the US around 1870, yet many abortions were performed. While estimates for the yearly number of pre-Roe illegal abortions roughly resemble today's number of legal abortions, the difference between legal and illegal abortion rests in the difference between the large number of women who died or were injured then, and the very few women who now die from illegal abortions. Along with the self-induced abortion, different categories of providers performed illegal abortions: physicians, nonphysicians, nurses, midwives, and lay people; all with varying skill, experience, and motives. While there were "butchers" and sexual exploiters, there were also competent, beloved physicians. There were the financially motivated physicians providing abortions full time, and the occasional providers acting with a sense of conscience, risking successful practices and jail. Within this "conscience" group of 44 interviewees gathered through personal networks, ads, etc., abortions were: performed outside of hospitals, reducing the risk of discovery, but creating greater medical risks; begun outside of a hospital with the intrusion into the uterus of an object, provoking a "spontaneous abortion" (miscarriage) needing completion by D and C (dilation and curettage) within a hospital, but only a limited number of such patients could be referred before arousing suspicion; and in a hospital under disguised circumstances, a very tricky undertaking with severe limitations, available only a few times before risking detection. Avoidance and lack of training by today's physicians and the well organized antiabortion groups will undoubtedly make illegal abortions even more difficult to engage in than the pre-Roe days. PMID:12317573

  15. 流产后服务模式的临床探讨%Investigatoin on clinical post abortion care

    袁贞明; 魏敏敏

    2015-01-01

    Objective:To investigate the clinical significance of immediate post abortion care after artificial abortion.Methods:The induced abortion young nulliparous women 480 cases were randomly divided into two groups, who accepted PAC after abortion are the treatment group (240cases), who do not accepted PAC after abortion are the observation group (240 case)s.The amount and duration of vaginal bleeding after induced abortion,the recovery of menstruation,take contraceptive measures and unwanted pregnancy once again after treatment were evaluated.Results:Shorter duration of vaginal bleeding,lower rate of complications such as intrauterine adhesions and ac -companying infection ,faster recovery of menstrual cycle after abortion , better contraception effect and lower unintended pregnancy rate once again were observed in the treatment group (P <0.05),.Conclusion:Immediate application of post abortion care after artificial a-bortion should be safe and effective and has additional benefit of contraception.%目的:探讨人工流产术后即时开展人工流产后服务( post abortion care, PAC)的临床意义。方法:将行人工流产的年轻未生育妇女480例随机分为2组,人工流产术后接受PAC者为治疗组(240例),不采用PAC者为观察组(240例)。观察2组术后出血及月经情况,采取避孕措施及再次非意愿妊娠情况。结果:观察组出血时间短,术后并发感染及宫腔粘连等并发症发生率低,流产后月经恢复快,且避孕效果优于观察组(P<0.05),再次非意愿妊娠率低。结论:人工流产后立即开展PAC是安全、有效,并具有额外益处的避孕方法。

  16. 流产后服务模式的临床探讨%Investigatoin on clinical post abortion care

    袁贞明; 魏敏敏

    2015-01-01

    目的:探讨人工流产术后即时开展人工流产后服务( post abortion care, PAC)的临床意义。方法:将行人工流产的年轻未生育妇女480例随机分为2组,人工流产术后接受PAC者为治疗组(240例),不采用PAC者为观察组(240例)。观察2组术后出血及月经情况,采取避孕措施及再次非意愿妊娠情况。结果:观察组出血时间短,术后并发感染及宫腔粘连等并发症发生率低,流产后月经恢复快,且避孕效果优于观察组(P<0.05),再次非意愿妊娠率低。结论:人工流产后立即开展PAC是安全、有效,并具有额外益处的避孕方法。%Objective:To investigate the clinical significance of immediate post abortion care after artificial abortion.Methods:The induced abortion young nulliparous women 480 cases were randomly divided into two groups, who accepted PAC after abortion are the treatment group (240cases), who do not accepted PAC after abortion are the observation group (240 case)s.The amount and duration of vaginal bleeding after induced abortion,the recovery of menstruation,take contraceptive measures and unwanted pregnancy once again after treatment were evaluated.Results:Shorter duration of vaginal bleeding,lower rate of complications such as intrauterine adhesions and ac -companying infection ,faster recovery of menstrual cycle after abortion , better contraception effect and lower unintended pregnancy rate once again were observed in the treatment group (P <0.05),.Conclusion:Immediate application of post abortion care after artificial a-bortion should be safe and effective and has additional benefit of contraception.

  17. A mechanism of transmission and factors affecting coral susceptibility to Halofolliculina sp. infection

    Rodríguez, S.; Cróquer, A.; Guzmán, H. M.; Bastidas, C.

    2009-03-01

    Anecdotal evidence collected since 2004 suggests that infections caused by ciliates in the genus Halofolliculina may be related to coral mortality in more than 25 scleractinian species in the Caribbean. However, the relationship between the presence of ciliates and coral mortality has not yet been firmly established. Field and laboratory manipulations were used to test if ciliate infections harm corals, if ciliates are able to infect healthy colonies, and if coral susceptibility to ciliate infection depends on temperature, depth, distance to an infected colony, and the presence of injuries. Ciliate infections were always characterized by a visually detectable front of ciliates located on recently exposed coral skeletons. These infections altered the normal structure of the colony by causing tissue mortality (0.8 ± 0.95 cm month-1, mean ± SD) and by delaying or preventing recovery from injuries. Under laboratory conditions, ciliates transmitted directly and horizontally from infected to healthy hosts, and coral susceptibility to ciliate infections increased with the presence of injuries. After invasion, the ciliate population grew, rapidly and after 8 d, produced tissue mortality on 32% of newly infected hosts. Thus, our results support the existence of a new Caribbean coral syndrome that is associated with tissue mortality, is infectious, and transmits directly and horizontally. Even though the role of ciliates in the development of lesions on coral tissues remains unclear, their presence is by far the most conspicuous sign of this syndrome; thus, we propose to name this condition Caribbean ciliate infection (CCI).

  18. Anti-inflammatory Mechanisms of Enteric Heligmosomoides polygyrus Infection on TNBS-Induced Colitis in a Murine Model

    To model the protective mechanism of helminth infection on colitis-induced changes in immune and epithelial cell function, BALB/c mice received intra-rectal saline or TNBS (2 mg/mouse; 40% ETOH) and were studied 4 days (d) later. Separate groups of mice received oral Heligmosomoides polygyrus follow...

  19. Biblical views on abortion: an Episcopal perspective.

    Wilson-kastner, P; Blair, B

    1985-01-01

    Much scholarly work has been done to determine the biblical and traditional attitudes about abortion. One must ask what was said and why, what was its context, and inquire about what was not said as well. This discussion identifies some of the conclusions reached in scholarly literature. The word "abortion" is not mentioned in the Bible, but much in the Bible speaks to the issue. The most obvious passage is from Exodus 21:22-25. This part of the Covenant Code legislates the case of a pregnant woman who becomes involved in a brawl between 2 men and has a miscarriage. A distinction is then made between the penalty that is to be exacted for the loss of the fetus and injury to the woman. For the fetus, a fine is paid as determined by the husband and the judges. However, if the woman is injured or dies, "lex talionis" is applied -- life for life, eye for eye, etc. The story has somewhat limited application to the current abortion debate since it deals with accidental and not willful pregnancy termination. Even so, the distinction made between the woman and the fetus is important. The woman is valued as a person under the convenant; the fetus is valued as property. Its status is certainly inferior to that of the woman. This passage gives no support to the parity argument that gives equal religious and moral worth to woman and fetus. The bibilical portrait of person does not begin with an explanation of conception but with a portrayal of the creation of Adam and Eve. Thus, the biblical portrait of a person is that of a complex, many-sided creature with the god-like ability and responsibility to make choices. The fetus does not meet those criteria. When considering the issue of abortion, the one who unquestionably fits this portrait of personhood is the pregnant woman. The abortion question focuses on the personhood of the woman, who in turn considers the potential personhood of the fetus in terms of the multiple dimensions of her own history and the future. In biblical

  20. Adolescent girls, illegal abortions and "sugar-daddies" in Dar es Salaam: vulnerable victims and active social agents

    Silberschmidt, M; Rasch, V

    2001-01-01

    they became pregnant, and many counted on an illegally induced abortion if they got pregnant. Even if adolescents are now allowed free access to family planning information, education and services, our study shows that this remains in the realm of theory rather than practice. Moreover, most adolescent......Adolescent girls' early sexual activity, early pregnancy, induced abortions and the increase in HIV infections have become major concerns in Sub-Saharan Africa. Efforts, though, to understand their sexual behaviour and to prevent reproductive health problems are almost non-existent. Adolescent...... willing preys and active social agents engaging in high-risk sexual behaviour. In order to get material benefits they expose themselves to serious health risks, including induced abortion - without realising their own vulnerability. In our study, one out of four girls had more than one partner at the time...

  1. Adolescent girls, illegal abortions and "sugar-daddies" in Dar es Salaam: vulnerable victims and active social agents

    Silberschmidt, Margrethe; Rasch, V

    2001-01-01

    Adolescent girls' early sexual activity, early pregnancy, induced abortions and the increase in HIV infections have become major concerns in Sub-Saharan Africa. Efforts, though, to understand their sexual behaviour and to prevent reproductive health problems are almost non-existent. Adolescent...... girls are normally seen as victims and easy preys of (often older and married) men's sexual exploitation. This article, which is based on a qualitative study of 51 adolescent girls who had just had an illegal abortion in Dar es Salaam, Tanzania, reveals that these girls are not only victims but also...... willing preys and active social agents engaging in high-risk sexual behaviour. In order to get material benefits they expose themselves to serious health risks, including induced abortion - without realising their own vulnerability. In our study, one out of four girls had more than one partner at the time...

  2. Seroprevalence of antibodies to Neospora caninum and associated abortion in dairy cattle from central Thailand.

    Suteeraparp, P; Pholpark, S; Pholpark, M; Charoenchai, A; Chompoochan, T; Yamane, I; Kashiwazaki, Y

    1999-09-15

    A total of 904 sera from dairy cattle in 11 provinces of central Thailand were tested for antibodies to Neospora caninum employing the indirect fluorescent antibody test (IFAT). Fifty four (6%) cattle were positive in IFAT, titres of 1:200 (16 cattle), 1:400 (9 cattle), 1:800 (14 cattle), 1:1600 (7 cattle), 1:3200 (6 cattle) and two positives. No significant difference was observed among the provinces. The seropositivity for Toxoplasma gondii by a commercial latex agglutination test was 4% (2 out of 50) in positive sera, 2.9% (2 out of 69) in negative sera for anti-Neospora antibodies and 3.4% (4 out of 119) in total. The results of the IFAT were not associated with the presence of antibodies to T. gondii in bovine sera. Furthermore, the cause of abortions experienced in neighbouring three areas in the northeast, where pregnant heifers were newly introduced into small-scale farms from the central region, was investigated. The positive rates for anti-N. caninum antibody were 12, 28 and 44% at a cut-off titre of 1:200, and cattle were suspected to be infected after the introduction. In the area with the highest rate, seven out of eight aborting cattle were positive for antibodies to N. caninum while other two areas had similar abortion rates in both negative and positive cattle. However, in the latter two areas, positive rates for Trypanosoma evansi antigen along with parasitaemic animals were observed by an antigen-detection ELISA, but not for the former area. Considering the endemic diseases of the areas, Neospora was presumed to be responsible for the abortions in the former area while the examination results pointed out T. evansi as the most probable cause in the latter two areas. This is the first report of Neospora-associated abortion in Southeast Asia. PMID:10489202

  3. Calmodulin Gene Expression in Response to Mechanical Wounding and Botrytis cinerea Infection in Tomato Fruit

    Hui Peng

    2014-08-01

    Full Text Available Calmodulin, a ubiquitous calcium sensor, plays an important role in decoding stress-triggered intracellular calcium changes and regulates the functions of numerous target proteins involved in various plant physiological responses. To determine the functions of calmodulin in fleshy fruit, expression studies were performed on a family of six calmodulin genes (SlCaMs in mature-green stage tomato fruit in response to mechanical injury and Botrytis cinerea infection. Both wounding and pathogen inoculation triggered expression of all those genes, with SlCaM2 being the most responsive one to both treatments. Furthermore, all calmodulin genes were upregulated by salicylic acid and methyl jasmonate, two signaling molecules involved in plant immunity. In addition to SlCaM2, SlCaM1 was highly responsive to salicylic acid and methyl jasmonate. However, SlCaM2 exhibited a more rapid and stronger response than SlCaM1. Overexpression of SlCaM2 in tomato fruit enhanced resistance to Botrytis-induced decay, whereas reducing its expression resulted in increased lesion development. These results indicate that calmodulin is a positive regulator of plant defense in fruit by activating defense pathways including salicylate- and jasmonate-signaling pathways, and SlCaM2 is the major calmodulin gene responsible for this event.

  4. Understanding virulence mechanisms in M. tuberculosis infection via a circuit-based simulation framework.

    May, Elebeoba Eni; Oprea, Tudor I.; Joo, Jaewook; Misra, Milind; Leitao, Andrei; Faulon, Jean-Loup Michel

    2008-08-01

    Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis (Mtb), is a growing international health crisis. Mtb is able to persist in host tissues in a non-replicating persistent (NRP) or latent state. This presents a challenge in the treatment of TB. Latent TB can re-activate in 10% of individuals with normal immune systems, higher for those with compromised immune systems. A quantitative understanding of latency-associated virulence mechanisms may help researchers develop more effective methods to battle the spread and reduce TB associated fatalities. Leveraging BioXyce's ability to simulate whole-cell and multi-cellular systems we are developing a circuit-based framework to investigate the impact of pathogenicity-associated pathways on the latency/reactivation phase of tuberculosis infection. We discuss efforts to simulate metabolic pathways that potentially impact the ability of Mtb to persist within host immune cells. We demonstrate how simulation studies can provide insight regarding the efficacy of potential anti-TB agents on biological networks critical to Mtb pathogenicity using a systems chemical biology approach

  5. Medical abortion: Modern method for termination of pregnancy

    Kapamadžija Aleksandra

    2010-01-01

    Full Text Available Introduction. Modern methods of medically induced abortions are being used in many countries all over the world. These methods are safe and effective when used in an appropriate way. Drugs used for medical abortion. The most widely used regimens for drug induced abortions include antiprogestogen mifepriston followed by administration of a synthetic prostaglandin analogue - gemeprost vaginally or misoprostol orally or vaginally. When used for abortions up to 9 and 7 weeks of pregnancy, this method has efficacy up to 98%. The regimen between 9 and 12 completed weeks is still under investigation. Methods for medical abortion after 12 completed weeks since last menstrual period include several regimens and medications - combination of mifepriston and repeated doses of misoprostol, misoprostol or gemeprost alone, methotrexate, synthetic prostaglandin analogues, oxytocin and some others. Medical abortions at our Department of Obstetrics and Gynecology, Novi Sad, Clinical Center Vojvodine, Serbia. Medical abortions in the second trimester were introduced at our Department of Obstetrics and Gynecology Novi Sad, Serbia, in early 1980s using prostaglandin analogues. This method was improved in year 2000 introducing two dinoprostone gels intracervically/extraamnially instead of just one, for cervical preparation before intramuscular application of carboprost thrometamine, which led to significantly shorter abortion interval. During the years 2003/2004 we took part successfully in one of the multicentric WHO projects for investigating new regimens on early medical abortions with mifepriston and misoprostol. Conclusions. Modern methods of medical abortions are safe and effective for termination of unwanted pregnancies in the first and second trimester.

  6. [On the question of the illegality of abortion].

    Salton, J A

    1985-08-01

    The illegality of abortion in Brazil is questioned more and more. It would seem obvious that the prohibition of abortion would result in a decrease in the number of abortions, but upon closer observation, the opposite is true. Abortion related legislation in Brazil is among the most severe in the world. Both the physician and the patient are equally punishable, but this did not stop Brazilian women from having 3.5 million abortions/year. Countries with less severe laws have a much lower abortion rate. There have been extreme physiological and social consequences in Brazil as a result of abortion's illegality. The woman is not only a criminal, she is also a sinner in the eyes of the Church. In most cases, especially in low-income areas, abortion can lead to complications and death. Although there are no statistical data on the number of deaths due to illegal abortion, they would no doubt be alarming. An unwanted, unterminated pregnancy can have disastrous effects upon the mother, the child, and their relationship. These negative effects have been well documented. Prohibition will keep abortion out of the mainstream of national debate and aggravate the situation. A person's sexuality cannot be suppressed and considered evil. In lower income levels, unwanted pregnancy should not be a punishment for being poor. The legalization movement will grow, as it has in developed nations. The members of the Brazilian Society for Scientific Progress must remain active in the debate, because they cannot ignore something of such national importance. PMID:12314816

  7. Ugandan opinion-leaders' knowledge and perceptions of unsafe abortion.

    Moore, Ann M; Kibombo, Richard; Cats-Baril, Deva

    2014-10-01

    While laws in Uganda surrounding abortion remain contradictory, a frequent interpretation of the law is that abortion is only allowed to save the woman's life. Nevertheless abortion occurs frequently under unsafe conditions at a rate of 54 abortions per 1000 women of reproductive age annually, taking a large toll on women's health. There are an estimated 148,500 women in Uganda who experience abortion complications annually. Understanding opinion leaders' knowledge and perceptions about unsafe abortion is critical to identifying ways to address this public health issue. We conducted in-depth, semi-structured interviews with 41 policy-makers, cultural leaders, local politicians and leaders within the health care sector in 2009-10 at the national as well as district (Bushenyi, Kamuli and Lira) level to explore their knowledge and perceptions of unsafe abortion and the potential for policy to address this issue. Only half of the sample knew the current law regulating abortion in Uganda. Respondents understood that the result of the current abortion restrictions included long-term health complications, unwanted children and maternal death. Perceived consequences of increasing access to safe abortion included improved health as well as overuse of abortion, marital conflict and less reliance on preventive behaviour. Opinion leaders expressed the most support for legalization of abortion in cases of rape when the perpetrator was unknown. Understanding opinion leaders' perspectives on this politically sensitive topic provides insight into the policy context of abortion laws, drivers behind maintaining the status quo, and ways to improve provision under the law: increase education among providers and opinion leaders. PMID:24064047

  8. Efforts underway to impose harsh regulations on abortion providers.

    Sollom, T

    1996-09-01

    Legislators or regulators in Mississippi, South Carolina, and Missouri have imposed burdensome and unnecessary clinic requirements on abortion providers. In each case, the legislators or regulators designed the requirements to make abortions more difficult to obtain. Mississippi, a state with only two licensed abortion clinics, already had restrictive abortion laws. In August 1996, it implemented stringent regulations on private physicians who provide abortion services in their offices. Some requirements include purchasing specific equipment, widening hallways, and hiring more staff. Several physicians have filed a lawsuit to stop enforcement of the regulations because they make the provision of abortion services so cumbersome and expensive as to discourage physicians from offering abortions. Antiabortion groups testified before the legislature that the Department of Health had been negligent in monitoring private practices for compliance with Mississippi's many abortion laws, particularly counseling requirements. The Republican governor signed the legislation in March 1996. In July 1996, a federal judge prohibited the South Carolina Department of Health from enforcing a new regulation making physicians who perform as few as five abortions a month to meet strict specifications for their office (e.g., disclosure of patient records and medical agreements). The regulation was a response to a 1995 law targeting private physicians who perform abortions in their offices. The judge held that the substantial changes in terms of privacy and expense could bring an undue burden on women seeking abortions. The state denied that the regulation would close clinics or would increase costs so much as to make abortions inaccessible. In September 1996, the House did not override the Democratic governor's veto of a bill that would have required all facilities where abortions are done to be licensed and undergo annual inspections and that would have required all physicians to have

  9. Considerations in Launch Vehicle Abort Capability and Failure Tolerance

    Hale, N. W., Jr.; Conte, B. A.

    2002-01-01

    operations, the Space Shuttle was designed to incur loss of thrust from one engine at liftoff and return safely to a runway. This is a very unusual capability in space launch vehicles and, if desired, must be designed into the system initially. For some extremely high value payloads on future expendable launch vehicles, this capability may be cost effective as well as for human space flights. Current designers may be inclined to design a "simple" emergency escape pod to resolve this issue. That may neither be the most effective nor the safest way to provide ascent failure tolerance. This paper discusses some real-world issues associated with this capability that the designers of the Space Shuttle did take into account that have become serious issues in real operations. paper discusses the affect of payload mass on abort capability. Issues related to abort modes can also be influence by other aspects of payload mass including center of gravity concerns. In a similar mode, consumables such as on-orbit attitude control propellant is a major factor in abort mode design. multiple engine failures during the powered ascent trajectory and have a happy outcome: landing on a runway. This paper discusses options and post-design fixes to the Space Shuttle to enhance multiple engine out capability. scenarios. include propellant underload on STS-61C, off nominal performance of engine clusters on STS-78 and STS-93, and other flights. Designers of these future human rated vehicles should consider the Space Shuttle experience in designing their systems. About the Authors: N. Wayne Hale, Jr. is currently the Deputy Chief for Shuttle of the NASA/JSC Flight Director Office. In 23 years with NASA at Houston's Johnson Space Center, he has served in the Mission Control Center for 41 Space Shuttle flights including 25 as Entry Flight Director. Mr. Hale received his Bachelor of Science Degree in Mechanical Engineering from Rice University in 1976 and his Master of Science Degree in

  10. [A glossary for discussion about abortion].

    Astete A, Carmen; Beca I, Juan Pablo; Lecaros U, Alberto

    2014-11-01

    Abortion and its diverse possible legal regulations is one of the major and toughest social controversies. This debate is even more problematic due to biases, prejudgments, different ideologies, beliefs, religious doctrines and political pressures. Chile has recently begun a new national discussion with an evident confusion, both in juridical and clinical terminology, which makes very difficult to achieve the necessary plural debate for a social and political consensus. The authors structured an academic collaborative project to create a glossary as a contribution for a discussion based on clearly defined notions about the different terms used in the abortion debate. Twenty-two concepts were selected and their definitions were reviewed and discussed by more than 50 different specialists. The final version of this glossary in Spanish language is presented. PMID:25694291

  11. [Abortion: legal, deontological and ethical framework].

    Canário, Catarina; Figueiredo, Bárbara; Ricou, Miguel

    2011-12-01

    Pregnancy interruption before fetal viability limit is inherent to a multidisciplinary reflection, due to the conflicts involved. Portuguese laws have been altered along time in the way of women's health protection, allowing the needed information and support towards a free, informed and enlightened decision. Deontological determinants about health professionals towards abortion indicate the practice accordingly the law. Nevertheless, it is safeguarded their right to consciousness objection. Ethical discussion about abortion, in its different ways, includes the concern about the value of intrauterine human life, and also the respect for individual autonomy. Even though the debate about intrauterine human life moral status is viewed from different theories and points of view, it is concluded that different perspectives about this matter are acceptable, in an interpersonal diversity valorization point of view. PMID:22863486

  12. 内分泌异常与复发性流产%Endocrine Abnormalities and Recurrent Spontaneous Abortion

    李倩; 梁晓燕

    2013-01-01

    The recurrent miscarriage is traditionally defined as three or more consecutive pregnancy losses before 20 weeks. The causes of recurrent spontaneous abortion are not clear,including genetic factors, uterine abnormalities,immunologic and endocrine factors,infections,and unexplained abortion. The endocrine disorders is related to recurrent miscarriage, including disorders of both reproductive glands and other glands. This article discussed the relationships between recurrent spontaneous abortion and endocrine disorders such as luteal insufficiency,thyroid dysfunction,hyperprolactinemia,insulin resistance and hyperandrogenism. However, it needs more study to understand the mechanism of recurrent miscarriage caused by endocrine abnormalities.%复发性流产是指在妊娠20周前,连续发生2次或以上自然流产。复发性流产的病因目前尚未明确,主要包括遗传因素、解剖异常、内分泌异常、感染、免疫因素及不明原因的复发性流产。其中内分泌异常与复发性流产密切相关,无论是生殖腺分泌功能异常或其他相关内分泌腺体分泌异常,都有可能导致复发性流产的发生。从黄体功能不足、甲状腺功能异常、高催乳素血症、胰岛素抵抗及高雄激素血症等方面,探讨内分泌异常与复发性流产之间的相关性。内分泌异常会导致复发性流产,但是其具体机制仍需要进一步探索。

  13. Orion Launch Abort System (LAS) Propulsion on Pad Abort 1 (PA-1)

    Jones, Daniel S.

    2015-01-01

    This presentation provides a concise overview of the highly successful Orion Pad Abort 1 (PA-1) flight test, and the three rocket motors that contributed to this success. The primary purpose of the Orion PA-1 flight was to help certify the Orion Launch Abort System (LAS), which can be utilized in the unlikely event of an emergency on the launchpad or during mission vehicle ascent. The PA-1 test was the first fully integrated flight test of the Orion LAS, one of the primary systems within the Orion Multi-Purpose Crew Vehicle (MPCV). The Orion MPCV is part of the architecture within the Space Launch System (SLS), which is being designed to transport astronauts beyond low-Earth orbit for future exploration missions. Had the Orion PA-1 flight abort occurred during launch preparations for a real human spaceflight mission, the PA-1 LAS would have saved the lives of the crew. The PA-1 flight test was largely successful due to the three solid rocket motors of the LAS: the Attitude Control Motor (ACM); the Jettison Motor (JM); and the Abort Motor (AM). All three rocket motors successfully performed their required functions during the Orion PA-1 flight test, flown on May 6, 2010 at the White Sands Missile Range in New Mexico, culminating in a successful demonstration of an abort capability from the launchpad.

  14. Virus-helminth co-infection reveals a microbiota-independent mechanism of immuno-modulation

    Osborne, Lisa C.; Monticelli, Laurel A.; Nice, Timothy J.; Sutherland, Tara E.; Siracusa, Mark C.; Hepworth, Matthew R.; Tomov, Vesselin T.; Kobuley, Dmytro; Tran, Sara V.; Bittinger, Kyle; Bailey, Aubrey G.; Laughlin, Alice L.; Boucher, Jean-Luc; Wherry, E. John; Bushman, Frederic D.

    2014-01-01

    The mammalian intestine is colonized by beneficial commensal bacteria and is a site of infection by pathogens, including helminth parasites. Helminths induce potent immuno-modulatory effects, but whether these effects are mediated by direct regulation of host immunity or indirectly through eliciting changes in the microbiota is unknown. We tested this in the context of virus-helminth co-infection. Helminth co-infection resulted in impaired antiviral immunity and was associated with changes in...

  15. Residential Exposure to Traffic and Spontaneous Abortion

    Green, Rochelle S; Malig, Brian; Windham, Gayle C.; Fenster, Laura; Ostro, Bart; Swan, Shanna

    2009-01-01

    Background Studies have shown associations between air pollution or traffic exposure and adverse birth outcomes, such as low birth weight. However, very few studies have examined the effect of traffic emissions on spontaneous abortion (SAB). Objective The goal of this study was to determine whether residential exposure to vehicular traffic was associated with SAB. Methods Pregnant women from a prepaid health plan in California were recruited into a prospective cohort study in 1990–1991. Three...

  16. Endogenous Candida endophthalmitis after induced abortion.

    Chen, S J; Chung, Y M; Liu, J H

    1998-06-01

    Reported, in this article, are the cases of two young women who developed endogenous Candida endophthalmitis after induced abortion. Both women experienced transient fever, chills, and abdominal pain after the abortion and were given antibiotics. The diagnosis of endophthalmitis was established on the basis of typical fundus appearance, positive vaginal culture, and (in one case) positive vitreous culture. In the first woman, who received vitrectomy and intravitreal amphotericin B injection, the affected eye had a best corrected visual acuity of 20/200. In the second woman, who was given systemic corticosteroid treatment before the correct diagnosis was reached, recurrent retinal detachment developed and the best corrected visual acuity was counting fingers. It appears that Candida organisms harbored in the genital tract are directly inoculated into the venous system during induced abortion. Once in the blood, if sufficient fungal load is present, Candida albicans tends to localize in the choroid and to spread toward the retina and vitreous cavity. The immunosuppressive effect of corticosteroids further increases the risk of endophthalmitis. PMID:9645729

  17. US poised to outlaw late abortion technique.

    Bozalis, D

    1995-11-18

    The House of Representatives passed a bill, by a two-thirds majority (288-139), prohibiting late (at 19-20 weeks gestation) abortion using intrauterine cranial decompression. The bill now awaits judgment from the Senate Judiciary Committee for hearings. If the bill becomes law, physicians performing the procedure could face up to two years in prison. Chris Smith, Republican cochairman of the House Pro-Life Caucus, who introduced the bill in the House, described the vote as historic. During his emotional speech, the procedure was described in order to desanitize a form of abortion that he called barbaric torture. Patricia Schroeder, Colorado House Representative, argued that the wording of the bill allowed the procedure only when it was the only possible way of saving the mother's life; the woman's health and future fertility were, in effect, set aside. There is no exception clause for when the woman's life or health is endangered. Schroeder fears women will be forced to choose more dangerous methods of abortion and believes more discussion is required regarding health risks and a more precise definition of when the procedure may be used. She is joined by the California Medical Association, the American Medical Women's Association, the American College of Obstetricians and Gynaecologists, and the American Medical Association. PMID:7496271

  18. Women and men’s psychological adjustment after abortion: a six months prospective pilot study

    Canário, Catarina; Figueiredo, Bárbara; Ricou, Miguel

    2011-01-01

    Background: The psychological impact of abortion is a controversial issue. While some studies indicate that women who had elective abortions present lower psychological distress when compared with those who had spontaneous or therapeutic abortions, other studies found abortion to be associated with significant psychological distress. Objectives: To assess psychological adjustment (emotional disorder, trauma symptoms and couple relationship) one and six months after abortion,...

  19. Association between Spontaneous abortion and Presence of anti thyroid antibodies in mother’s serum

    Mahmoud Mirhosseini

    2012-12-01

    Results: Out of 51 subjects, 18 had positive Anti-TPO-Ab, of which -10 were among the cases and 8 belonged to the controls. Out of 18 women with positive AntiTG-Ab, 11 cases were in the control group and 7 were in the cases. The differences between the control group and the amounts of Anti-TPO-Abs (P=0.468 and Anti-TG-Abs (P=0.675 were not swignificant. Conclusion: The results revealed that there is no association between abortion and presence of antithyroid antibodies in mother’s serum. Other abortion causes such as various kinds of infections and smoking might be involved which requires more research.

  20. Maternal smoking predicts the risk of spontaneous abortion

    Nielsen, Ann; Hannibal, Charlotte Gerd; Lindekilde, Bodil Eriksen;

    2006-01-01

    ) or who gave birth (n=1,578) during follow-up were selected. Associations between self-reported smoking at enrollment and subsequent spontaneous abortion were analyzed by means of multiple logistic regression. RESULTS: The risk of spontaneous abortion in relation to pre-pregnancy smoking showed a......BACKGROUND: Few studies have examined smoking prior to pregnancy and the occurrence of spontaneous abortion, as most studies have addressed the risk of spontaneous abortion in relation to smoking during pregnancy. However, results are not entirely consistent. The aim of the present study was to...... assess the risk of spontaneous abortion considering smoking prior to pregnancy. METHODS: We performed a nested case-control study using prospective data from a population-based cohort comprising 11,088 women aged 20-29 years. From this cohort, women who experienced either a spontaneous abortion (n=343...

  1. 25 years later, US abortion war still drags on.

    Rovner, J

    1998-01-31

    In the 25 years since the US Supreme Court's landmark Roe vs. Wade decision legalizing abortion, activists on both sides of the issue have drawn further apart as they have vied for the support of the majority of US voters who express ambivalence towards the law. These voters believe that abortion may be murder but that it must be legal. The Roe vs. Wade anniversary has sparked new legislative priorities on both sides. Abortion-rights activists will seek legislation that attempts to decrease the need for abortion by increasing funding for family planning services in the US and abroad, supporting funding for contraceptive research, and requiring health insurers to pay for contraceptives. Abortion opponents will continue to press for "partial birth" abortion bans and will support efforts to make it a federal crime for an adult to transport a minor across state lines to evade state parental notification or consent laws. PMID:9652629

  2. U.S. tries to defuse abortion debate.

    Struck, D

    1994-09-01

    In an apparent attempt to defuse acrimony at the International Conference on Population and Development, underway in Cairo, the US delegation is softening its stance on abortion decriminalization. US Vice President Al Gore, the head of the delegation, has stated, "The United States does not seek to establish a new international right to abortion, and we do not believe that abortion should be encouraged as a method of family planning." The Vatican and Muslim fundamentalists remain concerned, however, that the Cairo gathering represents an opportunity for the US to impose its abortion rights agenda on other countries. The draft prepared for presentation to the conference makes no explicit mention of legal abortion. Rather, it advocates safe motherhood, complete reproductive health care, and fertility control-- phrases the Vatican insists mask an intent to promote the use of abortion for family planning. PMID:12318927

  3. Measuring abortion-related mortality: challenges and opportunities.

    Gerdts, Caitlin; Tunçalp, Ozge; Johnston, Heidi; Ganatra, Bela

    2015-01-01

    Two recent efforts to quantify the causes of maternal deaths on a global scale generated divergent estimates of abortion-related mortality. Such discrepancies in estimates of abortion-related mortality present an important opportunity to explore unique challenges and opportunities associated with the generation and interpretation of abortion-related mortality estimates. While innovations in primary data collection and estimation methodologies are much needed, at the very least, studies that seek to measure maternal deaths due to abortion should endeavor to improve transparency, acknowledge limitations of data, and contextualize results. As we move towards sustainable development goals beyond 2015, the need for valid and reliable estimates of abortion-related mortality has never been more pressing. The post-MDG development agenda that aims to improve global health, reduce health inequities, and increase accountability, requires new and novel approaches be tested to improve measurement and estimation of abortion-related mortality, as well as incidence, safety and morbidity. PMID:26377189

  4. How Danes evaluate moral claims related to abortion

    Uldall, Sigurd Wiingaard

    2015-01-01

    OBJECTIVE: To investigate how Danish citizens evaluate four moral claims related to abortion issues, regarding the moral status of the fetus, autonomy, harm and possible negative consequences of allowing abortion and to explore the association between moral beliefs and attitudes towards abortion......-two responded to at least one moral claim. Two hundred and fifty-eight responded to all four claims without using the option 'neither agree nor disagree' and were classified as 'morally engaged responders'. A majority of these had a pro-abortion moral. The general relationship between moral beliefs and...... attitudes towards abortion was morally sound. Being 'morally engaged' did not increase the likelihood of reaching moral judgement on whether requests for abortion should be permitted. Education, religion and parenthood were statistically associated with the investigated issues. DISCUSSION: The direction of...

  5. Inflammatory and regenerative responses in salmonids following mechanical tissue damage and natural infection

    Ingerslev, Hans-Christian; Lunder, Tor; Nielsen, Michael Engelbrecht

    2010-01-01

    are coding for immunological factors and tissue regeneration. Locale, inflammatory responses were seen as strong up-regulation of IL-1β and IL-8 in both groups of fish, but it was more pronounced in infected fish. Expression of the toll-like receptors showed induction of TLR-5m following infection...

  6. Stewardship challenges abortion: A proposed means to mitigate abortion's social divisiveness.

    Tardiff, Robert G

    2015-08-01

    Since 1973 the legislated constitutional right to abortion has produced a political dichotomy (anti-abortion versus pro-abortion) within the United States, even while witnessing a gradual decline in the rate of abortions. A third paradigm, moral stewardship, is advanced as an effective means to ameliorate this social divisiveness. Incorporating the concept of stewardship into deliberations of pregnancy termination would require recognition, through fact-based education programs, of the life circumstances that prompt the consideration to terminate a pregnancy. Based on collective responsibility, policies, and programs are needed to foster social justice for parents and for the offspring brought to term, without creating excessive burdens on women faced with an unwanted pregnancy. Moral stewardship is perceived as humanitarian to family and community and advantageous to society overall. It also offers a serious opportunity to reshape our society from divisiveness to inclusiveness, and to guide science policy judgment that enhances and strengthens social justice. Lay summary: Differing opinions over the ethics of human abortion have been legion since Roe v. Wade (1973). The disputes between pro- and anti-abortion factions have segregated society with few improvements in social justice. This study offers an alternative approach, one capable of social assimilation and justice for unwanted offspring and pregnant mothers bearing them. It promotes moral stewardship toward the unborn whose humanity and personhood are recognized genetically and supported philosophically by long-standing ethical principles. Stewardship incorporates all people at all levels of society based on collective responsibility, supported by government policies, yet not restricting a mother's choices for the future of her unborn offspring. PMID:26912934

  7. Subclinical abortions in patients treated with clomiphene citrate

    Using radioimmunoassay for human chorionic gonadotrophin beta-subunit, 39 treatment cycles of clomiphene citrate therapy were studied prospectively for incidence of subclinical abortions. Eight treatment cycles resulted in clinically recognizable pregnancies and three other treatment cycles ended up with subclinical abortions. The plasma progesterone levels in patients with subclinical abortions at the 13th day after ovulation were lower than those in patients with normal pregnancies. (author)

  8. Abortions, Inequality and Intergenerational Mobility: A Quantitative Evaluation

    Georgi Kocharkov

    2010-01-01

    In the last three decades over a million abortions are performed annually in the United States. Empirical studies such as Donohue and Levitt (2001) and Gruber, Levine and Staiger (1999) assess the impact of legalization of abortions on crime and living conditions of children. They argue that legalization of abortions provides better living conditions and human capital endowments to surviving children. This paper takes seriously the hypothesis that the improved living conditions of children du...

  9. Impossible floodgates and unworkable analogies in the Irish abortion debate.

    de Londras, Fiona; Graham, Laura

    2013-01-01

    The debate about the introduction and form of abortion legislation in Ireland is rife with floodgate arguments, suggesting (either implicitly or expressly) that the introduction of abortion legislation within current constitutional boundaries would only be a starting point, following which so-called ‘abortion on demand’ would flow. The recent discussions at the Oireachtas Committee on Health and Children showed little prospect of a break from this pattern. At those hearings, a number of parli...

  10. We Should Protect Women’s Right of Abortion

    李玉萍

    2015-01-01

    <正>Many countries have legalized abortion such as China,America,Japan,France and Italy,but still about one third women cannot have a legal abortion around the world(Debate on Legality).Although two thirds women are protected by law on abortion,some of them cannot get support from others due to the bondage of religions and morality.Some people,especially

  11. Abortion among young women and subsequent life outcomes

    Casey, Patricia R.

    2010-01-01

    This article will discuss the nature of the association between abortion and mental health problems. Studies arguing about both sides of the debate as to whether abortion per se is responsible will be presented. The prevalence of various psychiatric disorders will be outlined and where there is dispute between studies, these will be highlighted. The impact of abortion on other areas such as education, partner relationships and sexual function will also be considered. The absence of specific i...

  12. Current abortion practices in India: a review of literature

    Naina Kumar

    2014-01-01

    Among issues related to reproductive health, none has more controversial connotations than abortion nor carries a heavier burden of stigmatization. Abortion, is a universal phenomenon and is defined as and has existed throughout recorded history, yet it continues to be a highly charged, controversial issue, raising extreme passions among lay people, as well as politicians, religious leaders, and health and rights advocates. Although abortion services in India were liberalized more than three ...

  13. Childhood adversities and subsequent risk of one or multiple abortions

    Steinberg, Julia R.; Tschann, Jeanne M

    2012-01-01

    Although many studies have found an association between childhood adversities and mental health disorders, few have examined whether childhood adversities are linked to having abortions. This research investigates the association between a range of childhood adversities and risk of abortion in part to identify which adversities should be considered when examining the association between abortion and subsequent mental health. Using the U.S. National Comorbidity Survey-Replication (NCS-R), we t...

  14. Why women seek abortion? a qualitative study on perspectives of rural women on abortion and contraception

    Fatima Shanthini Navis

    2015-08-01

    Conclusion: These findings highlight the need to improve rural women's knowledge of fertility and contraception. Media and service providers should use every possible opportunity to educate women regarding the legal status of abortion and to promote contraceptive usage by creating awareness regarding safety and free availability of various contraceptives thereby clearing misconceptions regarding contraception. There is a need to educate rural women that use of a regular contraceptive method is better than undergoing repeated abortions. [Int J Reprod Contracept Obstet Gynecol 2015; 4(4.000: 1153-1157

  15. Evaluation of bovine abortion cases and tissue suitability for identification of infectious agents in California diagnostic laboratory cases from 2007 to 2012.

    Clothier, K; Anderson, M

    2016-03-15

    Establishing a definitive cause of bovine abortion is a challenging problem faced by veterinary practitioners and diagnosticians. Detection of an infectious or noninfectious source for abortion may facilitate interventions that mitigate future fetal loss in the herd. The purposes of this study were to identify the most common causes of bovine abortion in cases submitted to the California Animal Health and Food Safety Laboratory System, Davis (CAHFS) from 2007 to 2013 and to determine if detection of infectious pathogens differed with the fetal tissue evaluated. Records of 665 bovine abortion cases of 709 animals were reviewed for pathologic diagnoses, test methods used to identify causative conditions, and which tissues yielded successful identification of infectious agents associated with abortion. Over 58% of abortions were attributed to an infectious cause and 46.9% had an infectious agent identified. The most common infectious conditions were Epizootic Bovine Abortion (EBA) (16.2% of all fetuses), other fetal bacterial infections (14.7% of all fetuses), and Neospora caninum (9.3% of all fetuses.) The bacterium associated with EBA (currently named Pajaroellobacter abortibovis) was most commonly identified by immunohistochemistry (IHC) in lymphoid organs (thymus and spleen); N. caninum IHC was most frequently positive in brain, kidney, and placenta. In cases of pathogenic and opportunistic bacterial infections, abomasal samples yielded a significantly greater proportion of definitive aerobic culture results than lung or liver tissues. Direct fluorescent antibody test results for Bovine Viral Diarrhea Virus testing were identical between lung and kidney tissues and nearly identical (96.0%) for Bovine Herpesvirus I. Noninfectious abortive conditions included fetal stress (10.5%), dystocia (3.9%), congenital defects (3.3%), toxicological or mineral problems (1.8%), and death of the cow (1.1%). Just over 20% of the aborted fetuses had no gross or histopathological

  16. Single and repeated elective abortions in Japan: a psychosocial study.

    Kitamura, T; Toda, M A; Shima, S; Sugawara, M

    1998-09-01

    Despite its social, legal and medical importance, termination of pregnancy (TOP) (induced abortion) has rarely been the focus of psychosocial research. Of a total of 1329 women who consecutively attended the antenatal clinic of a general hospital in Japan, 635 were expecting their first baby. Of these 635 women, 103 (16.2%) had experienced TOP once previously (first aborters), while 47 (7.4%) had experienced TOP two or more times (repeated aborters). Discriminant function analysis was performed using psychosocial variables found to be significantly associated with either first abortion or repeated abortion in bivariate analyses. This revealed that both first and repeated aborters could be predicted by smoking habits and an unwanted current pregnancy while the repeated aborters appear to differ from first aborters in having a longer pre-marital dating period, non-arranged marriages, smoking habits, early maternal loss experience or a low level of maternal care during childhood. These findings suggest that both the frequency of abortion and its repetition have psychosocial origins. PMID:9844843

  17. The abortion-crime link: evidence from England and Wales

    L H Kahane; Paton, D; Simmons, R.

    2005-01-01

    We use panel data from 1983 to 1997 for the 42 police force areas in England and Wales to test the hypothesis that legalizing abortion contributes to lower crime rates. We provide an advance on previous work by focusing on the impact of possible endogeneity of effective abortion rates with respect to crime. Our use of U.K. data allows us to exploit regional differences in the provision of free abortions to identify abortion rates. When we use a similar model and estimation methodology, we are...

  18. Do Induced Abortions Affect the First Birth Probability?

    Hansen, Marie-Louise H; Stage, Louise; Knudsen, Lisbeth B.;

    Objective: The focus of this paper is to study, on a national basis, how the event of an induced abortion modifies the transition to first birth for Danish women aged 20-39 years in the period 1982-2001, taking into account also educational level, family situation, and urbanisation. Data and...... abortion is examined by cumulative first birth probabilities, derived from a life table analysis. Main findings and conclusion: Previous abortions increased the first birth probability, though this effect was almost entirely confined to single women. For cohabiting and married women, previous abortions had...

  19. [Decriminalization of abortion: a common purpose in Latin America].

    1993-12-01

    In the conviction that abortion is a fundamental right of women and that its illegal practice constitutes a serious threat to life, several Latin American women's groups have united to work for decriminalization. The groups have been attempting to increase public awareness of the consequences of illegal abortion. Official silence on the topic appears to deny the existence of a problem. Proposals in the different Latin American countries are adapted to their political and legal circumstances. In Argentina, a campaign has been underway for nearly two years to collect signatures for a petition for a law concerning contraception and abortion. The National Network for Women's Health and other groups have held regional and national workshops on the issue. In Bolivia, radio and television programs have been broadcast in Spanish and indigenous languages on the right to choose, reproductive health, and sex education. Abortion was debated in Brazil during the process of constitutional reform, but it remains illegal. Illegal abortion continues to be a reality and women's groups are lobbying for decriminalization. Abortion is considered a crime in Colombia's penal code. Attempts to legalize abortion have been rejected by the legislature without debate. The practice of abortion under the circumstances has become a lucrative business whose lack of regulation has resulted in a growing number of maternal deaths. Attempts are underway in Costa Rica to legalize abortion in cases of rape or incest. Studies show that illegal abortion is the third most important cause of maternal death. A bill to legalize abortion is under study in Chile's Parliament but has not been approved. Abortion is illegal but common in Ecuador. Efforts are underway in Mexico and Nicaragua to encourage debate on abortion. Peru's Health Commission was recently prevented from classifying abortion for any reason other than grave congenital anomaly as homicide. Abortion has been legal in Puerto Rico since 1974, but

  20. Mechanisms of alcohol-mediated hepatotoxicity in humanimmunodeficiency- virus-infected patients

    Gyongyi Szabo; Samir Zakhari

    2011-01-01

    Clinical observations have demonstrated that excessive chronic alcohol use negatively affects human immunodeficiency virus (HIV) infection and contributes to the liver manifestations of the disease, even in HIV monoinfection. HIV/hepatitis C virus (HCV) co-infection is associated with increased progression of HVC liver disease compared to HCV infection alone, and both of these are negatively affected by alcohol use. Recent data suggest that alcohol use and HIV infection have common targets that contribute to progression of liver disease. Both HIV infection and chronic alcohol use are associated with increased gut permeability and elevated plasma levels of lipopolysaccharide; a central activator of inflammatory responses. Both alcoholic liver disease and HIV infection result in non-specific activation of innate immunity, proinflammatory cytokine cascade upregulation, as well as impaired antigen presenting cell and dendritic cell functions. Finally, alcohol, HIV and antiretroviral therapy affect hepatocyte functions, which contributes to liver damage. The common targets of alcohol and HIV infection in liver disease are discussed in this mini-review.

  1. Caspase-8 activity is part of the BeWo trophoblast cell defense mechanisms against Trypanosoma cruzi infection.

    Carrillo, Ileana; Droguett, Daniel; Castillo, Christian; Liempi, Ana; Muñoz, Lorena; Maya, Juan Diego; Galanti, Norbel; Kemmerling, Ulrike

    2016-09-01

    Congenital Chagas disease is caused by the protozoan parasite Trypanosoma cruzi that must cross the placental barrier during transmission. The trophoblast constitutes the first tissue in contact with the maternal-blood circulating parasite. Importantly, the congenital transmission rates are low, suggesting the presence of local placental defense mechanisms. Cellular proliferation and differentiation as well as apoptotic cell death are induced by the parasite and constitute part of the epithelial turnover of the trophoblast, which has been suggested to be part of those placental defenses. On the other hand, caspase-8 is an essential molecule in the modulation of trophoblast turnover by apoptosis and by epithelial differentiation. As an approach to study whether T. cruzi induced trophoblast turnover and infection is mediated by caspase-8, we infected BeWo cells (a trophoblastic cell line) with the parasite and determined in the infected cells the expression and enzymatic activity of caspase-8, DNA synthesis (as proliferation marker), β-human chorionic gonadotropin (β-hCG) (as differentiation marker) and activity of Caspase-3 (as apoptotic death marker). Parasite load in BeWo cells was measured by DNA quantification using qPCR and cell counting. Our results show that T. cruzi induces caspase-8 activity and that its inhibition increases trophoblast cells infection while decreases parasite induced cellular differentiation and apoptotic cell death, but not cellular proliferation. Thus, caspase-8 activity is part of the BeWo trophoblast cell defense mechanisms against T. cruzi infection. Together with our previous results, we suggest that the trophoblast turnover is part of local placental anti-parasite mechanisms. PMID:27328973

  2. Transcriptomic Analysis of Resistant and Susceptible Bombyx mori Strains Following BmNPV Infection Provides Insights into the Antiviral Mechanisms.

    Li, Gang; Qian, Heying; Luo, Xufang; Xu, Pingzhen; Yang, Jianhua; Liu, Mingzhu; Xu, Anying

    2016-01-01

    Purpose. To decipher transcriptomic changes and related genes with potential functions against Bombyx mori nucleopolyhedrovirus infection and to increase the understanding of the enhanced virus resistance of silkworm on the transcriptomic level. Methods. We assembled and annotated transcriptomes of the Qiufeng (susceptible to infection) and QiufengN (resistant to infection) strains and performed comparative analysis in order to decipher transcriptomic changes and related genes with potential functions against BmNPV infection. Results. A total of 78,408 SNPs were identified in the Qiufeng strain of silkworm and 56,786 SNPs were identified in QiufengN strain. Besides, novel AS events were found in these 2 strains. In addition, 1,728 DEGs were identified in the QiufengN strain compared with Qiufeng strain. These DEGs were involved in GO terms related to membrane, metabolism, binding and catalytic activity, cellular processes, and organismal systems. The highest levels of gene representation were found in oxidative phosphorylation, phagosome, TCA cycle, arginine and proline metabolism, and pyruvate metabolism. Additionally, COG analysis indicated that DEGs were involved in "amino acid transport and metabolism" and "carbohydrate transport and metabolism." Conclusion. We identified a series of major pathological changes in silkworm following infection and several functions were related to the antiviral mechanisms of silkworm. PMID:27195279

  3. Possible mechanisms of host resistance to Haemonchus contortus infection in sheep breeds native to the Canary Islands

    Guo, Zhengyu; González, Jorge Francisco; Hernandez, Julia N.; McNeilly, Tom N.; Corripio-Miyar, Yolanda; Frew, David; Morrison, Tyler; Yu, Peng; Li, Robert W.

    2016-01-01

    Haemonchus contortus appears to be the most economically important helminth parasite for small ruminant production in many regions of the world. The two sheep breeds native to the Canary Islands display distinctly different resistant phenotypes under both natural and experimental infections. Canaria Hair Breed (CHB) tends to have significantly lower worm burden and delayed and reduced egg production than the susceptible Canaria Sheep (CS). To understand molecular mechanisms underlying host resistance, we compared the abomasal mucosal transcriptome of the two breeds in response to Haemonchus infection using RNAseq technology. The transcript abundance of 711 and 50 genes were significantly impacted by infection in CHB and CS, respectively (false discovery rate <0.05) while 27 of these genes were significantly affected in both breeds. Likewise, 477 and 16 Gene Ontology (GO) terms were significantly enriched in CHB and CS, respectively (P < 1.0 × 10−4). A broad range of mechanisms have evolved in resistant CHB to provide protection against the parasite. Our findings suggest that readily inducible acute inflammatory responses, complement activation, accelerated cell proliferation and subsequent tissue repair, and immunity directed against parasite fecundity all contributed to the development of host resistance to parasitic infection in the resistant breed. PMID:27197554

  4. Rice-Infecting Pseudomonas Genomes Are Highly Accessorized and Harbor Multiple Putative Virulence Mechanisms to Cause Sheath Brown Rot.

    Ian Lorenzo Quibod

    Full Text Available Sheath rot complex and seed discoloration in rice involve a number of pathogenic bacteria that cannot be associated with distinctive symptoms. These pathogens can easily travel on asymptomatic seeds and therefore represent a threat to rice cropping systems. Among the rice-infecting Pseudomonas, P. fuscovaginae has been associated with sheath brown rot disease in several rice growing areas around the world. The appearance of a similar Pseudomonas population, which here we named P. fuscovaginae-like, represents a perfect opportunity to understand common genomic features that can explain the infection mechanism in rice. We showed that the novel population is indeed closely related to P. fuscovaginae. A comparative genomics approach on eight rice-infecting Pseudomonas revealed heterogeneous genomes and a high number of strain-specific genes. The genomes of P. fuscovaginae-like harbor four secretion systems (Type I, II, III, and VI and other important pathogenicity machinery that could probably facilitate rice colonization. We identified 123 core secreted proteins, most of which have strong signatures of positive selection suggesting functional adaptation. Transcript accumulation of putative pathogenicity-related genes during rice colonization revealed a concerted virulence mechanism. The study suggests that rice-infecting Pseudomonas causing sheath brown rot are intrinsically diverse and maintain a variable set of metabolic capabilities as a potential strategy to occupy a range of environments.

  5. Rice-Infecting Pseudomonas Genomes Are Highly Accessorized and Harbor Multiple Putative Virulence Mechanisms to Cause Sheath Brown Rot.

    Quibod, Ian Lorenzo; Grande, Genelou; Oreiro, Eula Gems; Borja, Frances Nikki; Dossa, Gerbert Sylvestre; Mauleon, Ramil; Cruz, Casiana Vera; Oliva, Ricardo

    2015-01-01

    Sheath rot complex and seed discoloration in rice involve a number of pathogenic bacteria that cannot be associated with distinctive symptoms. These pathogens can easily travel on asymptomatic seeds and therefore represent a threat to rice cropping systems. Among the rice-infecting Pseudomonas, P. fuscovaginae has been associated with sheath brown rot disease in several rice growing areas around the world. The appearance of a similar Pseudomonas population, which here we named P. fuscovaginae-like, represents a perfect opportunity to understand common genomic features that can explain the infection mechanism in rice. We showed that the novel population is indeed closely related to P. fuscovaginae. A comparative genomics approach on eight rice-infecting Pseudomonas revealed heterogeneous genomes and a high number of strain-specific genes. The genomes of P. fuscovaginae-like harbor four secretion systems (Type I, II, III, and VI) and other important pathogenicity machinery that could probably facilitate rice colonization. We identified 123 core secreted proteins, most of which have strong signatures of positive selection suggesting functional adaptation. Transcript accumulation of putative pathogenicity-related genes during rice colonization revealed a concerted virulence mechanism. The study suggests that rice-infecting Pseudomonas causing sheath brown rot are intrinsically diverse and maintain a variable set of metabolic capabilities as a potential strategy to occupy a range of environments. PMID:26422147

  6. Are all abortions equal? Should there be exceptions to the criminalization of abortion for rape and incest?

    Cohen, I Glenn

    2015-01-01

    Politics, public discourse, and legislation restricting abortion has settled on a moderate orthodoxy: restrict abortion, but leave exceptions for pregnancies that result from rape and incest. I challenge that consensus and suggest it may be much harder to defend than those who support the compromise think. From both Pro-Life and Pro-Choice perspectives, there are good reasons to treat all abortions as equal. PMID:25846041

  7. Morganella sp. rods – characteristics, infections, mechanisms of resistance to antibiotics 

    Patrycja Zalas-Więcek

    2012-04-01

    Full Text Available The Morganella genus is one member of the tribe Proteae, which also includes the genera Proteus and Providencia. These bacteria are commonly present in the environment.Morganella sp. rods are known to be a causative agent of opportunistic hospital infections, mainly urinary tract, wound and blood infections of severe and high mortality, even in cases of an appropriate antibiotic.These bacteria may produce many virulence factors, for example urease, hemolysins, LPS, adhesins and enzymes hydrolyzing and modifying antibiotics commonly used to treat infections.Understanding the diverse biological properties of these rods may be of importance in the development of effective methods of prevention and control of infections with their participation. 

  8. Down-regulation of mechanisms involved in cell transport and maintenance of mucosal integrity in pigs infected with Lawsonia intracellularis

    Smith, Sionagh H; Wilson, Alison D.; Van Ettinger, Imke; MacIntyre, Neil; Archibald, Alan L.; Ait-Ali, Tahar

    2014-01-01

    International audience Lawsonia intracellularis is an obligate intracellular bacterium, responsible for the disease complex known as proliferative enteropathy (PE). L. intracellularis is associated with intestinal crypt epithelial cell proliferation but the mechanisms responsible are yet to be defined. Microarray analysis was used to investigate the host-pathogen interaction in experimentally infected pigs to identify pathways that may be involved. Ileal samples originating from twenty-eig...

  9. C-Reactive Protein Protects Mice against Pneumococcal Infection via Both Phosphocholine-Dependent and Phosphocholine-Independent Mechanisms

    Gang, Toh B.; Hanley, Gregory A.; Agrawal, Alok

    2015-01-01

    The mechanism of action of C-reactive protein (CRP) in protecting mice against lethal Streptococcus pneumoniae infection is unknown. The involvement of the phosphocholine (PCh)-binding property of CRP in its antipneumococcal function previously has been explored twice, with conflicting results. In this study, using three different intravenous sepsis mouse models, we investigated the role of the PCh-binding property of CRP by employing a CRP mutant incapable of binding to PCh. The ability of w...

  10. Small-area variations in utilization of abortion services in Ontario from 1985 to 1992.

    L E Ferris; McMain-Klein, M

    1995-01-01

    OBJECTIVE: To assess interregional differences in the utilization of abortion services in Ontario from 1985 to 1992. DESIGN: Retrospective analysis of provincial therapeutic abortion database. SETTING: All hospitals conducting abortions between 1985 and 1992 and all free-standing abortion clinics conducting abortions between 1990 and 1992. POPULATION: All women in Ontario aged 15 to 44 years who underwent a therapeutic abortion in Ontario during the study period. OUTCOME MEASURES: Utilization...

  11. Aberrant DNA methylation in 5'regions of DNA methyltransferase genes in aborted bovine clones

    2008-01-01

    High rate of abortion and developmental abnormalities is thought to be closely associated with inefficient epigenetic reprogramming of the transplanted nuclei during bovine cloning.It is known that one of the important mechanisms for epigenetic reprogramming is DNA methylation.DNA methylation is established and maintained by DNA methyltransferases(DNMTs),therefore,it is postulated that the inefficient epigenetic reprogramming of transplanted nuclei may be due to abnormal expression of DNMTs.Since DNA methylation can strongly inhibit gene expression,aberrant DNA methylation of DNMT genes may disturb gene expression.But presently,it is not clear whether the methylation abnormality of DNMT genes is related to developmental failure of somatic cell nuclear transfer embryos.In our study,we analyzed methylation patterns of the 5' regions of four DNMT genes including Dnmt3a,Dnmt3b,Dnmtl and Dnmt2 in four aborted bovine clones.Using bisulfite sequencing method,we found that 3 out of 4 aborted bovine clones(AF1,AF2 and AF3)showed either hypermethylation or hypomethylation in the 5' regions of Dnmt3a and Dnmt3b.indicating that Dnmt3a and Dnmt3b genes are not properly reprogrammed.However,the individual AF4 exhibited similar methylation level and pattern to age-matched in vitro fertilized (IVF)fetuses.Besides,we found that tle 5'regions of Dnmtl and Dnmt2 were nearly completely unmethylated in all normal adults.IVF fetuses,sperm and aborted clones.Together,our results suggest that the aberrant methylation of Dnmt3a and Dnmt3b 5' regions is probably associated with the high abortion of bovine clones.

  12. [Prevention of habitual abortion by buffycoat transfusions].

    Neumeyer, H; Kuhn, W; Götze, O; Hinney, B

    1985-01-01

    From an immunological point of view the product of pregnancy may be regarded as a haplo-different allotransplant. A system possibly closely linked to the HLA-region is postulated to lead to the immunological recognition of the fetus by the mother and, paradoxically, to a take of the "transplant". The postulated system apparently codes for antigens present on both trophoblast and adult lymphocytes (TLX = trophoblast-lymphocyte-crossreacting). The prevention of rejection is thought to be effected by blocking factors (BF) present in the serum or plasma of the mother. There may be different kinds of BF: a specific BF (detectable only in an autologous assay system), appearing late in pregnancy, which inhibits several lymphocyte-dependent reactions (e.g. production of MIF, MLC). This BF has been identified as an IgG-class antibody. a nonspecific BF, appearing early in pregnancy which inhibits the MLC in vitro. c) may be a third BF, also specific, which is found only in plasma but not in serum. All described BF-activities were absent in women with habitual abortions. HLA-identity or partial identity could imply TLX-identity. The consequence of such an identity could be: non-detection of the trophoblast by the immune system of the mother, no production of BF, abortion. However several investigators could not find any HLA-identity of the partners with habitual abortions. A protective effect on the fetus has been seen when pregnant women were immunised with adult leukocytes, using either buffycoats from various HLA-different but bloodgroup-compatible donors or isolated leukocytes from the spouse.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:4072314

  13. Coxiella burnetii infections in sheep or goats

    Brom, Van den R.; Engelen, van E.; Roest, H.I.J.; Hoek, van der W.; Vellema, P.

    2015-01-01

    Q fever is an almost ubiquitous zoonosis caused by Coxiella burnetii, which is able to infect several animal species, as well as humans. Cattle, sheep and goats are the primary animal reservoirs. In small ruminants, infections are mostly without clinical symptoms, however, abortions and stillbirt

  14. Decision making by single women seeking abortion.

    Quinn, M

    1980-01-01

    30 single women attending the Auckland Medical Aid Center (AMAC) for an abortion during a 3-week period in May 1977 were interviewed about the factors leading up to the pregnancy, the impact of the pregnancy on their relationships with relevant others, and the process of obtaining an abortion. The prospective subjects were divided into 2 age groups, 16-20 and 21-25 years and 2 residence groups, Auckland city area or beyond this area. The proportion of the sample selected from each category was intended to approximate proportions as reported for all AMAC clientele. Of the 30 women interviewed, half were aged less than 20 years and half were more than 20. 24 of the women were European and the remainder Polynesian. 3 women had previously been married, in 2 cases resulting in children. 3 women had given birth; 2 of these women were solo parents while 1 woman had had her child adopted. All those who had either married or given birth were in the 21-25 year age group. In 20 cases the women had decided on abortion either before pregnancy even occurred or as soon as it was confirmed. This along with the fact that only 2 women in this sample actually made the decision to seek an abortion after arriving at the clinic suggests that counseling directed at helping women decide the future of the pregnancy after arrival at the hospital is largely superfluous. Other major problems of the women which caused considerable stress included obtaining a doctor's referral to AMAC, the physical difficulties in getting to AMAC, changes the pregnancy precipitated in relationships between women and those they confided in. 2/3 of the younger group made little or no use of contraception. None gave ignorance as a reason for nonuse. Women in the older age group tended to use more sophisticated techniques, such as oral contraception (OC), IUD, or diaphragm; the younger women relied on condoms or used nothing at all. In addition to the 7 women who had never used contraception, a further 12 women

  15. [Abortion: a public health or a family planning problem].

    Aguayo Hernandez, J R

    1991-01-01

    This work discusses various views of abortion and presents data on the legal aspects and incidence of abortion in Mexico as a contribution to a more productive dialogue on the problems of abortion. It is very difficult to deter women who have decided to seek an abortion, regardless of whether the procedure is legal or even safe. In the state of Sinaloa, Mexico, an abortion has not been punishable since 1939 if it caused by "imprudence", if the woman is a victim of rape, or if the woman's life is endangered by pregnancy. The penal codes of most Mexican states and the Federal District contain similar provisions. In October 1990, the state of Chiapas decriminalized abortion for most indications in the 1st 90 days of pregnancy on the basis that the fertility and growth rates were too high, many children were in situations of extreme poverty, and the widespread practice of illegal abortion led to high rates of maternal morbidity and mortality. The decree legalizing abortion in Chiapas was suspended in early 1991 by the Congress of Chiapas and is currently under further study by the National Commission on Human Rights. UNICEF estimates that in 1990, some 100,000 illegal abortions occurred daily in the world. 150,000-200,000 women may die each year as a result of illegal abortions. Today some 300 million couples throughout the world do not want more children but lack access to family planning. UNICEF estimates that the world rate of population growth would decline by 30% if all couples not desiring children practiced effective contraception. A large number of illegal abortions are believed to occur annually in Mexico. Abortions in Mexico are most common among married women of lower or lower middle class who already have children and who wish to avoid the economic hardships of a new baby. Perhaps because of their illegality, abortions represent a significant expense for a household. Unsafe abortions may cause serious health and fertility problems for women. The Mexican

  16. C-reactive protein protects mice against pneumococcal infection via both phosphocholine-dependent and phosphocholine-independent mechanisms.

    Gang, Toh B; Hanley, Gregory A; Agrawal, Alok

    2015-05-01

    The mechanism of action of C-reactive protein (CRP) in protecting mice against lethal Streptococcus pneumoniae infection is unknown. The involvement of the phosphocholine (PCh)-binding property of CRP in its antipneumococcal function previously has been explored twice, with conflicting results. In this study, using three different intravenous sepsis mouse models, we investigated the role of the PCh-binding property of CRP by employing a CRP mutant incapable of binding to PCh. The ability of wild-type CRP to protect mice against infection was found to differ in the three models; the protective ability of wild-type CRP decreased when the severity of infection was increased, as determined by measuring mortality and bacteremia. In the first animal model, in which we used 25 μg of CRP and 10(7) CFU of pneumococci, both wild-type and mutant CRP protected mice against infection, suggesting that the protection was independent of the PCh-binding activity of CRP. In the second model, in which we used 25 μg of CRP and 5 × 10(7) CFU of pneumococci, mutant CRP was not protective while wild-type CRP was, suggesting that the protection was dependent on the PCh-binding activity of CRP. In the third model, in which we used 150 μg of CRP and 10(7) CFU of pneumococci, mutant CRP was as protective as wild-type CRP, again indicating that the protection was independent of the PCh-binding activity of CRP. We conclude that both PCh-dependent and PCh-independent mechanisms are involved in the CRP-mediated decrease in bacteremia and the resulting protection of mice against pneumococcal infection. PMID:25690104

  17. Studies on Expression of IGF-Ⅱ Gene in Deciduas De-rived from Medical Abortion Patients

    刘峻; 汪玉宝; 毛叶萌; 毛全福; 杜晓岩

    2000-01-01

    Objective To determine the effect of insulin-like growth factor- Ⅱ (IGF- Ⅱ ) upon the maintenance of decidua in early pregnancy and its relationship with progesterone, as well as its role in medical abortion.Materials & Methods Decidua tissue was obtained from 28 women who undergoing surgical abortion and 39 for medical abortion respectively at 5~7 weeks of gestation.The extracted total RNA was reversely transeripted and amplified by PCR with spe-cific primers (IGF- Ⅱ and β-actin). The products were semi-quantitated by MIAS 300 system and qualitatively analyzed by southern blotting.Results The expression of IGF- Ⅱ gene in decidua from surgical abortion was signif-icantly higher than that from medical abortion (P<0. 05). The average IGF- Ⅱ gene transcription values were 1.54±0. 79 and 0. 72± 0. 39 respectively. The results of southern blotting proved qualitatively that the RT-PCR products were IGF- Ⅱ cDNA.Conclusion IGF- Ⅱ plays a role in the maintenance of decidua in early pregnancy. It may act as a mediator of progestin. It's also involved in the molecular mechanism of mifepristone.

  18. Ovine and Caprine Brucellosis (Brucella melitensis in Aborted Animals in Jordanian Sheep and Goat Flocks

    Assadullah Samadi

    2010-01-01

    Full Text Available Two hundred and fifty five biological samples were collected from 188 animals (81 sheep and 107 goats during the lambing season from September 2009 to April 2010 from the Mafraq region of Jordan. Sampled animals belonged to 93 sheep and goat flocks that had abortion cases in the region. One hundred and seven (41.9% biological samples were positive for the omp2 primers that were able to identify all Brucella species in the collected samples which were obtained from 86 aborted animals (86/188=45.7%. Using the B. melitensis insertion sequence 711 (IS711 primers on the 107 omp2 positive samples, only 61 confirmed to be positive for B. melitensis. These positive samples were obtained from 28 sheep and 33 goats. The prevalence rate of B. melitensis was 27.1% (51/188 among aborted animals. For differentiation between vaccine strain and field strain infection, polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP method using PstI endonuclease enzyme was used. Vaccination with Rev-1 in the last year (OR=2.92, CI: 1.1–7.7 and grazing at common pasture (OR=2.78, CI: 1.05–7.36 were statistically significant (P≤.05 risk factors positively associated with the occurrence of brucellosis in sheep and goat flocks.

  19. Veterinary and medical aspects of abortion in Danish sheep

    Agerholm, Jørgen S.; Aalbæk, Bent; Fog-Larsen, Anne Marie;

    2006-01-01

    The Danish sheep population totals around 144,000 animals, but little is known of the causes and prevalance of diseases. This study focuses on the causes of abortion in Danish sheep. During one breeding season, aborted foetuses and stillbirths with signs of intrauterine death or malformation were...

  20. Demographic and clinical profile of patients with complicated unsafe abortion

    To describe the demographic and clinical profile of patients admitted as a result of complicated unsafe abortion. The study was carried out in the Department of Obstetrics and Gynaecology, Jinnah Hospital, Lahore from August 2001 to July 2002. Patients admitted with complicated unsafe abortion were evaluated regarding age, parity, marital and educational status, indication for abortion, method used, qualification of abortion providers, contraceptive usage, complications and death rate in abortion seekers. Descriptive statistics was used for describing variables. Fiftynine patients were admitted with complicated unsafe abortion. The mean age was 29 years, 95% were married and multiparous, 40% had secondary and higher education, 85% approached unqualified abortion providers who used instrumentation in more than 40% of cases for termination of pregnancy resulting in visceral trauma. More than 50% were using contraception and 5% died due to postabortion complications. Unsafe abortion is a major health problem. The associated morbidity is much higher than mortality. This study focus on the need of postabortion care and easy accessibility to contraception to improve quality of health. (author)

  1. International comparison of regulations on abortion after radiation exposure

    Possible factors to consider when assessing the necessity of an abortion are: 1) Exposure in the highly sensitive phase (e.g. organogenesis); 2) after intake of radioactive substances, accumulation of this radioactive substance in critical organs; 3) doses higher than the dose limit of 1 rem; 4) the wish of the pregnant woman to have an abortion. (orig.)

  2. Grief and Elective Abortion: Breaking the Emotional Bond?

    Peppers, Larry G.

    1988-01-01

    Used maternal-infant bonding as theoretical framework to examine grief and elective abortion in 80 women who terminated their pregnancies either by vacuum aspiration, dilitation and evacuation, or intrauterine induction. Found grief associated with elective abortion to be symptomatically similar to grief experienced following involuntary…

  3. The American abortion debate: culture war or normal discourse?

    Dillon, M

    1995-01-01

    This paper investigates whether James Hunter's culture war thesis is an apt characterization of the American abortion debate. The author focuses on three arguments central to Hunter's analysis: 1) that the abortion debate involves two paradigmatically opposed world views; 2) that debate about abortion, since it involves moral discourse, is structurally different than other political debates; and 3) that the new alignments in abortion politics are culturally significant. Examining existing research in each of these three domains, the author finds that the debate over abortion is more complex than suggested by Hunter. World views of pro-life and pro-choice activists, for example, share a commitment to some overlapping values; the argumentative structure of abortion discourse has a pattern rather similar to that of political debate more generally, and new alignments on abortion, such as that between the Catholic Church and the Southern Baptist Convention, do not displace historically embedded differences in symbolic resources and cultural orientation. As suggested by the author, it may be more helpful, therefore, to think of the abortion debate as an ongoing public conversation about America's cultural tradition and how it should be variously expressed in contemporary laws and practices. PMID:12320388

  4. The incidence of gonorrhea in an abortion population

    Querido, L.; Haspels, A.A.

    1980-01-01

    The incidence of gonorrhea was investigated in an abortion population. A total of 1021 women participated in this study. Three asymptomatic cases of gonorrhea were detected. None of these women had had gonorrhea before or had a previous abortion. No relation was found between the incidence of gonorr

  5. Abortion-Related Services: Value Clarification through "Difficult Dialogues" Strategies

    Mpeli, Moliehi Rosemary; Botma, Yvonne

    2015-01-01

    Midwives play a pivotal role in women's health in the face of increased deaths related to backyard abortions. Since the commencement in South Africa of the Name of the Act No. 92 of 1996 that allows abortion services, there has been a moral divide among healthcare workers in South Africa. This article reflects the opinions of preregistration…

  6. Pine needle abortion biomarker detected in bovine fetal fluids

    Pine needle abortion is a naturally occurring condition in free-range cattle caused by the consumption of pine needles from select species of cypress, juniper, pine, and spruce trees. Confirmatory diagnosis of pine needle abortion has previously relied on a combined case history of pine needle cons...

  7. Regulating Abortion: Impact on Patients and Providers in Texas

    Colman, Silvie; Joyce, Ted

    2011-01-01

    The State of Texas began enforcement of the Woman's Right to Know (WRTK) Act on January 1, 2004. The law requires that all abortions at or after 16 weeks' gestation be performed in an ambulatory surgical center (ASC). In the month the law went into effect, not one of Texas's 54 nonhospital abortion providers met the requirements of a surgical…

  8. Contraception and Induced Abortion in the West Indies: A Review

    Boersma, A.A.; Bruijn, de J.G.M.

    2011-01-01

    Abstract BACKGROUND: Most islands in the West Indies do not have liberal laws on abortion, nor laws on pregnancy prevention programmes (contraception). We present results of a literature review about the attitude of healthcare providers and women toward (emergency) contraception and induced abortion

  9. Abortion in Young Women and Subsequent Mental Health

    Fergusson, David M.; Horwood, L. John; Ridder, Elizabeth M.

    2006-01-01

    Background: The extent to which abortion has harmful consequences for mental health remains controversial. We aimed to examine the linkages between having an abortion and mental health outcomes over the interval from age 15-25 years. Methods: Data were gathered as part of the Christchurch Health and Development Study, a 25-year longitudinal study…

  10. Medicine and abortion law: complicating the reforming profession.

    McGuinness, Sheelagh; Thomson, Michael

    2015-01-01

    The complicated intra-professional rivalries that have contributed to the current contours of abortion law and service provision have been subject to limited academic engagement. In this article, we address this gap. We examine how the competing interests of different specialisms played out in abortion law reform from the early twentieth-century, through to the enactment of the Abortion Act 1967, and the formation of the structures of abortion provision in the early 1970s. We demonstrate how professional interests significantly shaped the landscape of abortion law in England, Scotland, and Wales. Our analysis addresses two distinct and yet related fields where professional interests were negotiated or asserted in the journey to law reform. Both debates align with earlier analysis that has linked abortion law reform with the market development of the medical profession. We argue that these two axes of debate, both dominated by professional interests, interacted to help shape law's treatment of abortion, and continue to influence the provision of abortion services today. PMID:25995361

  11. Space shuttle three main engine return to launch site abort

    Carter, J. F.; Bown, R. L.

    1975-01-01

    A Return-to-Launch-Site (RTLS) abort with three Space Shuttle Main Engines (SSME) operational was examined. The results are trajectories and main engine cutoff conditions that are approximately the same as for a two SSME case. Requiring the three SSME solution to match the two SSME abort eliminates additional crew training and is accomplished with negligible software impact.

  12. Commercial availability of misoprostol and induced abortion in Brazil.

    Costa, S H

    1998-12-01

    In Brazil, abortion is only permitted to save the woman's life or in cases of rape. The principal effect of legal restrictions is not to make induced abortion practice less prevalent but to force poor women to resort to abortions performed under unhygienic conditions or attempt self-induced abortion. Within this context, misoprostol, a synthetic analogue of prostaglandin E1, was introduced in the country in 1986. Purchased over the counter in pharmacies, misoprostol has became a popular abortifacient method among Brazilian women. By 1990, about 70% of women hospitalized with abortion-related diagnoses reported use of the drug. In 1991, the Ministry of Health restricted the sale of misoprostol, and in some states its use was totally banned. While the proportion of abortions induced with misoprostol has decreased, the drug continues to be sold on the black market at an inflated value. Research indicates that women have acquired more experience with the drug over time, resulting in lower doses and more effective administration. Several studies show that the rate and severity of complications are significantly less among women who used misoprostol compared with women who used invasive methods. Research also suggests that about half of the women have complete abortion with misoprostol, but seek medical care as soon as they have vaginal bleeding. The experience of Brazilian women with misoprostol is an example of how women when faced with unwanted pregnancy will resort to illegal abortion whatever the costs are to their health. PMID:10075223

  13. Making legal abortion available in Brazil: partnerships in practice.

    Villela, W V; Araújo, M J

    2000-11-01

    This article describes the participation of feminist groups who work in the area of women's reproductive health and rights in campaigns for the provision of legal abortion in public hospitals in Brazil. Brazilian criminal law permits therapeutic abortion in cases where pregnancy is the result of rape or poses a serious risk to the life of the woman. Today, as a result of the combined efforts of feminists, health professionals and policymakers, more than 20 hospitals in Brazil are officially permitted to perform therapeutic abortions within the existing law. A model programme has also been developed to train service providers to do legal abortions, where the agreement of a hospital board can be obtained. This training has also improved care for illegally obtained, incomplete abortions in those hospitals but not in hospitals where doctors have not been trained. Problems with lack of access and concerns about the lack of public acceptance of abortion remain. Women not only need the right to abortion but also more services and health professionals who are trained to perform abortions across the whole country. PMID:11424253

  14. Co-infection by porcine circovirus type 2 and porcine parvovirus in aborted fetuses and stillborn piglets in southern Brazil Co-infecção por circovírus suíno tipo 2 e parvo-vírus suíno em fetos abortados e natimortos suínos no Sul do Brasil

    Caroline A. Pescador; Paulo M. Bandarra; Luiza A. Castro; Nadia A.B. Antoniassi; Ana Paula Ravazzolo; Luciana Sonne; Cláudio E.F. Cruz; David Driemeier

    2007-01-01

    Porcine circovirus types 1 and 2 (PCV1, PCV2) and porcine parvovirus (PPV) are widespread in pig populations around the world. Nevertheless, only PCV2 has been associated with different clinical syndromes, thus representing a major problem to the pig industry. The association of cases of swine abortions and stillborns with PCV1 and PCV2 and PPV was studied retrospectively (2005-2007). Additional pathogens were also investigated in lesioned fetuses. The studied litters included stillborn pigle...

  15. Social and psychological consequences of abortion in Iran.

    Hosseini-Chavoshi, Meimanat; Abbasi-Shavazi, Mohammad Jalal; Glazebrook, Diana; McDonald, Peter

    2012-09-01

    Iran has had replacement fertility since 2000. Upholding a small family size has led some couples to terminate unwanted pregnancies. Abortion is, however, permitted only on medical grounds in Iran. Using data from the Iran Low Fertility Survey, this study assessed sociodemographic correlates of abortion among a random sample of 5526 ever-married women aged 15-54 years, and used in-depth interviews to explore reasons for and psychological consequences of abortion among 40 women who had experienced an unintended pregnancy. Although social and economic concerns were the main reasons cited for seeking abortion, women experienced anxiety and depression when seeking pregnancy termination and thereafter. Social stigmatization arose from a belief that abortion is sinful and that misfortune experienced thereafter is punishment. Inadequate knowledge and misunderstanding of relevant Sharia laws discouraged women from seeking care when they experienced complications. Iran's reproductive health policies should be revised to integrate pre- and postabortion counseling. PMID:22920623

  16. Self-management of medical abortion: a qualitative evidence synthesis.

    Wainwright, Megan; Colvin, Christopher J; Swartz, Alison; Leon, Natalie

    2016-05-01

    Medical abortion is a method of pregnancy termination that by its nature enables more active involvement of women in the process of managing, and sometimes even administering the medications for, their abortions. This qualitative evidence synthesis reviewed the global evidence on experiences with, preferences for, and concerns about greater self-management of medical abortion with lesser health professional involvement. We focused on qualitative research from multiple perspectives on women's experiences of self-management of first trimester medical abortion (administration of medical abortion. We highlight particular considerations when offering self-management options, and identify key areas for future research. Further qualitative research is needed to strengthen this important evidence base. PMID:27578349

  17. Acquired Immune Deficiency Syndrome, Risky Sexual Behavior and Abortion

    Marshall H. Medoff

    2012-01-01

    Full Text Available Problem statement: incidence of abortion in the United States has steadily declined since 1990. The question is why? Approach: This study, using multiple linear regression, examines whether women’s unprotected sexual activity is deterred by the risk of contracting AIDS as reflected in decreased abortion rates. Results: The empirical evidence consistently finds that the prevalence of AIDS reduces the risky (unprotected sexual activity of women of childbearing ages 15-44 as reflected in their abortion rates. The empirical results remain robust for the abortion rates of teens ages 15-17 and for teens ages 15-19. Conclusion: The empirical results suggest that the behavioral modification induced by the prevalence of AIDS accounted for 21% of the decrease in abortion rates over the time period 1992-2005.

  18. Stumbling on status: abortion, stem cells, and faulty reasoning.

    Lebacqz, Karen

    2012-02-01

    Common arguments from the abortion debate have set the stage for the debate on stem cell research. Unfortunately, those arguments demonstrate flawed reasoning-jumping to unfounded conclusions, using value laden language rather than careful argument, and ignoring morally relevant aspects of the situation. The influence of flawed abortion arguments on the stem cell debate results in failures of moral reasoning and in lack of attention to important morally relevant differences between abortion and human embryonic stem cells. Among those differences are whose interests are at stake and the difference between an embryo in and out of the womb. Stem cell research differs from abortion in morally relevant ways and should be freed from the abortion debate and its flawed reasoning. PMID:22209889

  19. Infection Mechanism of Neovossaia horrida in Male Sterile Lines of Rice (Oryza sativa L.)

    Zhu Jianqing(朱建清); Liu Zhu; Liao Jinhua; Tao Jiafeng; Yang Zhirong; Zhao Jian

    2004-01-01

    After male sterile rice plants are inoculated with secondary sporidia of Neovossia horrida in the field, the process of infection is comparatively studied in four male sterile rice lines by scanning electronmicroscope. The infection process of Neovossia horrida is similar in these four male sterile lines. The results show, that the hyphae of fungus penetrates directly to the stigma, and then to the ovary after inoculation for 8h. The initial teliospore is formed between the aleurone layer and seed coat after 7d and matured in 9d. Although fungus penetrates through stigma without pollination, teliospore occurs only in the healthy developing endosperma.

  20. Surrogate Motherhood and Abortion for Fetal Abnormality.

    Walker, Ruth; van Zyl, Liezl

    2015-10-01

    A diagnosis of fetal abnormality presents parents with a difficult - even tragic - moral dilemma. Where this diagnosis is made in the context of surrogate motherhood there is an added difficulty, namely that it is not obvious who should be involved in making decisions about abortion, for the person who would normally have the right to decide - the pregnant woman - does not intend to raise the child. This raises the question: To what extent, if at all, should the intended parents be involved in decision-making? In commercial surrogacy it is thought that as part of the contractual agreement the intended parents acquire the right to make this decision. By contrast, in altruistic surrogacy the pregnant woman retains the right to make these decisions, but the intended parents are free to decide not to adopt the child. We argue that both these strategies are morally unsound, and that the problems encountered serve to highlight more fundamental defects within the commercial and altruistic models, as well as in the legal and institutional frameworks that support them. We argue in favour of the professional model, which acknowledges the rights and responsibilities of both parties and provides a legal and institutional framework that supports good decision-making. In particular, the professional model acknowledges the surrogate's right to decide whether to undergo an abortion, and the intended parents' obligation to accept legal custody of the child. While not solving all the problems that arise in surrogacy, the model provides a framework that supports good decision-making. PMID:25688455

  1. Making legal abortion accessible in Brazil.

    Faúndes, Anibal; Leocádio, Elcylene; Andalaft, Jorge

    2002-05-01

    Abortion is legal in Brazil if it is the only means to save the woman's life or if the pregnancy is the result of rape. Although this has been the law for over 60 years, it has almost never been applied until recent years. In the past five years, the number of hospitals providing care to women victims of sexual violence has increased from 4 to 63, of which 40 are currently providing legal abortions. This paper describes a sensitization project and advocacy work carried out from within the obstetric and gynaecology establishment which has succeeded in motivating many key individuals and hospital staff to provide services for pregnancy termination in cases of rape. The dialogue between medical leaders and women's rights advocates and the emphasis on comprehensive care of women who have suffered sexual violence are key elements in the success of this initiative. The support of medical professionals, the organization and strength of the women's health and rights movement, the political support at federal, state and city government levels, including from the Federal Ministry of Health, and ongoing advocacy within the medical establishment have all been important elements in making the provision of services a reality. PMID:12369314

  2. Relationship of hepatitis B virus infection of placental barrier and hepatitis B virus intra-uterine transmission mechanism

    Han Bai; Lin Zhang; Li Ma; Xiao-Guang Dou; Guo-He Feng; Gui-Zhen Zhao

    2007-01-01

    AIM: To explore the mechanism of intra-uterine transmission, the HBV infection status of placental tissue and in vitro cultured placental trophoblastic cells was tested through in vivo and in vitro experiments.METHODS: A variety of methods, such as ELISA, RTPCR, IHC staining and immunofluorescent staining were employed to test the HBV marker positive pregnant women's placenta and in vitro cultured placental trophoblastic cells.RESULTS: The HBV DNA levels in pregnant women's serum and fetal cord blood were correlated. For those cord blood samples positive for HBV DNA, their maternal blood levels of HBV DNA were at a high level. The HBsAg IHC staining positive cells could be seen in the placental tissues and the presence of HBV DNA detected. After coincubating the trophoblastic cells and HBV DNA positive serum in vitro, the expressions of both HBsAg and HBV DNA could be detected.CONCLUSION: The mechanism of HBV intra-uterine infection may be due to that HBV breaches the placental barrier and infects the fetus.

  3. Characteristics of Induced Abortion in China in the 1990s

    Xiao-chun QIAO

    2007-01-01

    Objective To understand the characteristics of induced abortion in China in the 1990s,and to find out the influential factors.Methods The overall number of induced abortions, calculate cohort induced abortion frequency, explore the impact of a child's sex and the number of previous children on induced abortions were estimated by using the data from the "National Population and Reproductive Health Survey" conducted by the National Family Planning Commission in November 1997.Results Induced abortions in China had their own characteristics, which were far different from other countries. The main difference was led by the fact that the country was driven by an implemented family planning program and nationwide population policies. The key cause of induced abortions was due to an inconsistency with the requirements of the family planning policy. However, as a result of effective and prevalent contraception, the rates of induced abortions were not quite high in the 1990s,when compared with other countries. Even though, in the early 1990s, the government had reinforced the family planning program through administration and legislation,unlike during the early 1980s when the one-child policy was implemented, the induced abortion rate and the number of induce abortions did not increase as the fertility rate substantially decreased.Concltsion This finding implies that the fertility declines in the 1990s were not caused by the number of induced abortions. The transition of the fertility ideology of the people has played an important role in the fertility decline, as institutional reform and socioeconomic development are implemented.

  4. Cytochrome c dysregulation induced by HIV infection of astrocytes results in bystander apoptosis of uninfected astrocytes by an IP3 and calcium-dependent mechanism

    Eugenin, Eliseo A.; Berman, Joan W.

    2013-01-01

    HIV entry into the CNS is an early event after peripheral infection, resulting in neurologic dysfunction in a significant number of individuals despite successful anti-retroviral therapy. The mechanisms by which HIV mediates CNS dysfunction are not well understood. Our group recently demonstrated that HIV infection of astrocytes results in survival of HIV infected cells and apoptosis of surrounding uninfected astrocytes by the transmission of toxic intracellular signals through gap junctions....

  5. Pine needle abortion in cattle update: Metabolite detection in sera and fetal fluids from abortion case samples

    Cattle abortions associated with consumption of pine needles during late gestation are a serious poisonous plant problem in the Western US. Most cases of abortion have been associated with consumption of ponderosa pine (Pinus ponderosa) and the causative agent was identified as the labdane diterpen...

  6. Behavioral mechanisms and morphological symptoms of zombie ants dying from fungal infection

    Hughes, David P; Andersen, Sandra B; Hywel-Jones, Nigel L;

    2011-01-01

    Parasites that manipulate host behavior can provide prominent examples of extended phenotypes: parasite genomes controlling host behavior. Here we focus on one of the most dramatic examples of behavioral manipulation, the death grip of ants infected by Ophiocordyceps fungi. We studied the interac...

  7. Molecular mechanisms of dengue virus infection : cell tropism, antibody-dependent enhancement, and cytokines

    Flipse, Jacobus

    2015-01-01

    Dengue is the most prevalent mosquito-borne viral disease in humans. Although most infections occur in the (sub)tropical areas, recent outbreaks in Italy and Madeira indicate that the virus is spreading into Europe. Despite its relevance, no vaccine or medications are available against this virus. T

  8. Molecular mechanisms involved in antibody-dependent enhancement of dengue virus infection in humans

    Flipse, Jacky; Wilschut, Jan; Smit, Jolanda M.

    2013-01-01

    Dengue is the most common arthropod-borne viral infection in humans with similar to 50 million cases annually worldwide. In recent decades, a steady increase in the number of severe dengue cases has been seen. Severe dengue disease is most often observed in individuals that have pre-existing immunit

  9. Exploring the host transcriptome for mechanisms underlying protective immunity and resistance to helminth infection in ruminants

    Helminth infections in ruminants are a major impediment to the profitable production of meat and dairy products, especially for small farmers. Gastrointestinal parasitism is not just a disease that negatively impacts productivity, including reduced weight gain and milk yield, but is also a leading ...

  10. Prevalence of Mycoplasma genitalium, Mycoplasma hominis and Chlamydia trachomatis among Danish patients requesting abortion

    Baczynska, Agata; Hvid, Malene; Lamy, P;

    2008-01-01

    The aim of the study was to determine lower genital tract carriage rate of Mycoplasma genitalium (M. genitalium) and to compare it to the carriage rates of Mycoplasma hominis (M. hominis ) and Chlamydia trachomatis (C. trachomatis) among 102 women requesting termination of pregnancy at the Horsens....... There was no correlation between the presence of genital infection with C. trachomatis and genital mycoplasmas and no correlation between the presence of antibodies to these bacteria. In conclusion, in Danish patients it is not necessary to test for M. genitalium before abortion since less than 1% were...

  11. Behavioral mechanisms and morphological symptoms of zombie ants dying from fungal infection

    Himaman Winanda

    2011-05-01

    Full Text Available Abstract Background Parasites that manipulate host behavior can provide prominent examples of extended phenotypes: parasite genomes controlling host behavior. Here we focus on one of the most dramatic examples of behavioral manipulation, the death grip of ants infected by Ophiocordyceps fungi. We studied the interaction between O. unilateralis s.l. and its host ant Camponotus leonardi in a Thai rainforest, where infected ants descend from their canopy nests down to understory vegetation to bite into abaxial leaf veins before dying. Host mortality is concentrated in patches (graveyards where ants die on sapling leaves ca. 25 cm above the soil surface where conditions for parasite development are optimal. Here we address whether the sequence of ant behaviors leading to the final death grip can also be interpreted as parasite adaptations and describe some of the morphological changes inside the heads of infected workers that mediate the expression of the death grip phenotype. Results We found that infected ants behave as zombies and display predictable stereotypical behaviors of random rather than directional walking, and of repeated convulsions that make them fall down and thus precludes returning to the canopy. Transitions from erratic wandering to death grips on a leaf vein were abrupt and synchronized around solar noon. We show that the mandibles of ants penetrate deeply into vein tissue and that this is accompanied by extensive atrophy of the mandibular muscles. This lock-jaw means the ant will remain attached to the leaf after death. We further present histological data to show that a high density of single celled stages of the parasite within the head capsule of dying ants are likely to be responsible for this muscular atrophy. Conclusions Extended phenotypes in ants induced by fungal infections are a complex example of behavioral manipulation requiring coordinated changes of host behavior and morphology. Future work should address the

  12. Gene expression profiling of dendritic cells reveals important mechanisms associated with predisposition to Staphylococcus infections.

    Mehdi Toufeer

    Full Text Available BACKGROUND: Staphylococcus aureus is a major pathogen of humans and animals and emerging antibiotic-resistant strains have further increased the concern of this health issue. Host genetics influence susceptibility to S. aureus infections, and the genes determining the outcome of infections should be identified to find alternative therapies to treatment with antibiotics. Here, we used outbred animals from a divergent selection based on susceptibility towards Staphylococcus infection to explore host immunogenetics. METHODOLOGY/PRINCIPAL FINDINGS: We investigated how dendritic cells respond to heat-inactivated S. aureus and whether dendritic cells from animals showing different degrees of susceptibility had distinct gene expression profiles. We measured gene expression levels of in vitro S. aureus-stimulated bone marrow-derived dendritic cells at three different time points (0, 3 and 8 hrs by using 15 k ovine Agilent microarrays. Furthermore, differential expression of a selected number of genes was confirmed by RT-qPCR. Gene signatures of stimulated DCs were obtained and showed that genes involved in the inflammatory process and T helper cell polarization were highly up-regulated upon stimulation. Moreover, a set of 204 genes were statistically differentially expressed between susceptible and resistant animals, and grouped them according to their predisposition to staphylococcal infection. Interestingly, over-expression of the C1q and Ido1 genes was observed in the resistant line and suggested a role of classical pathway of complement and early regulation of inflammation pathways, respectively. On the contrary, over expression of genes involved in the IL1R pathway was observed in susceptible animals. Furthermore, the leucocyte extravasation pathway was also found to be dominant in the susceptible line. CONCLUSION/SIGNIFICANCE: We successfully obtained Staphylococcus aureus associated gene expression of ovine BM-DC in an 8-hour kinetics experiment

  13. Gene Expression Profiling of Dendritic Cells Reveals Important Mechanisms Associated with Predisposition to Staphylococcus Infections

    Toufeer, Mehdi; Bonnefont, Cécile M. D.; Foulon, Eliane; Caubet, Cécile; Tasca, Christian; Aurel, Marie-Rose; Robert-Granié, Christèle; Rupp, Rachel; Foucras, Gilles

    2011-01-01

    Background Staphylococcus aureus is a major pathogen of humans and animals and emerging antibiotic-resistant strains have further increased the concern of this health issue. Host genetics influence susceptibility to S. aureus infections, and the genes determining the outcome of infections should be identified to find alternative therapies to treatment with antibiotics. Here, we used outbred animals from a divergent selection based on susceptibility towards Staphylococcus infection to explore host immunogenetics. Methodology/Principal Findings We investigated how dendritic cells respond to heat-inactivated S. aureus and whether dendritic cells from animals showing different degrees of susceptibility had distinct gene expression profiles. We measured gene expression levels of in vitro S. aureus-stimulated bone marrow-derived dendritic cells at three different time points (0, 3 and 8 hrs) by using 15 k ovine Agilent microarrays. Furthermore, differential expression of a selected number of genes was confirmed by RT-qPCR. Gene signatures of stimulated DCs were obtained and showed that genes involved in the inflammatory process and T helper cell polarization were highly up-regulated upon stimulation. Moreover, a set of 204 genes were statistically differentially expressed between susceptible and resistant animals, and grouped them according to their predisposition to staphylococcal infection. Interestingly, over-expression of the C1q and Ido1 genes was observed in the resistant line and suggested a role of classical pathway of complement and early regulation of inflammation pathways, respectively. On the contrary, over expression of genes involved in the IL1R pathway was observed in susceptible animals. Furthermore, the leucocyte extravasation pathway was also found to be dominant in the susceptible line. Conclusion/Significance We successfully obtained Staphylococcus aureus associated gene expression of ovine BM-DC in an 8-hour kinetics experiment. The distinct

  14. Outbreak of Salmonella Dublin-associated abortion in Danish fur farms

    Dietz, Hans Henrich; Chriél, Mariann; Andersen, Thomas Holmen; Jorgensen, Jens Christian; Torpdahl, Mia; Pedersen, Hans; Pedersen, Karl

    2006-01-01

    Outbreaks of Salmonella Dublin infections were recorded in 25 Danish mink and fox farms. All farms suffered extensive disease problems; clinical and pathological observations included abortion, stillbirths, necrotizing endometritis, and increased mortality. By genotyping with pulsed-field gel...... electrophoresis and amplified fragment length polymorphism, all isolates of S. Dublin had indistinguishable patterns. The outbreaks took place during April and May, around the time of whelping. During this period, mink are particularly susceptible to Salmonella infections. All affected farms were served by the...... measures at feed factories and the proper use of ingredients of known Salmonella status, in particular during the whelping season. Infected mink farms did not have a higher risk of outbreak of salmonellosis in the year following the outbreak....

  15. Characterising the mechanism of airway smooth muscle β2 adrenoceptor desensitization by rhinovirus infected bronchial epithelial cells.

    David Van Ly

    Full Text Available Rhinovirus (RV infections account for approximately two thirds of all virus-induced asthma exacerbations and often result in an impaired response to β2 agonist therapy. Using an in vitro model of RV infection, we investigated the mechanisms underlying RV-induced β2 adrenoceptor desensitization in primary human airway smooth muscle cells (ASMC. RV infection of primary human bronchial epithelial cells (HBEC for 24 hours produced conditioned medium that caused β2 adrenoceptor desensitization on ASMCs without an effect on ASMCs viability. Less than 3 kDa size fractionation together with trypsin digestion of RV-induced conditioned medium did not prevent β2 adrenoceptor desensitization, suggesting it could potentially be mediated by a small peptide or lipid. RV infection of BECs, ASMCs and fibroblasts produced prostaglandins, of which PGE2, PGF2α and PGI2 had the ability to cause β2 adrenoceptor desensitization on ASMCs. RV-induced conditioned medium from HBECs depleted of PGE2 did not prevent ASMC β2 adrenoceptor desensitization; however this medium induced PGE2 from ASMCs, suggesting that autocrine prostaglandin production may be responsible. Using inhibitors of cyclooxygenase and prostaglandin receptor antagonists, we found that β2 adrenoceptor desensitization was mediated through ASMC derived COX-2 induced prostaglandins. Since ASMC prostaglandin production is unlikely to be caused by RV-induced epithelial derived proteins or lipids we next investigated activation of toll-like receptors (TLR by viral RNA. The combination of TLR agonists poly I:C and imiquimod induced PGE2 and β2 adrenoceptor desensitization on ASMC as did the RNA extracted from RV-induced conditioned medium. Viral RNA but not epithelial RNA caused β2 adrenoceptor desensitization confirming that viral RNA and not endogenous human RNA was responsible. It was deduced that the mechanism by which β2 adrenoceptor desensitization occurs was by pattern recognition receptor

  16. House vote on Hyde changes dynamic of Congressional abortion debate.

    1993-07-27

    US Congressional action is summarized for actions taken on abortion amendments and abortion funding amendments during the month of July 1993. The Hyde Amendment was passed in the House on July 1, 1993; by a margin of 255 to 178; the Senate version will be voted on in August. The amendment was a victory for anti-abortion supporters, because it limited coverage of abortions under Medicaid to cases involving only life endangerment, rape, or incest. Both sides of the abortion debate were energized by the vote. The national Campaign for Abortion and Reproductive Equity (CARE) was launched on July 13 through support from a coalition of 130 organizations and Representatives Maxine Waters, Cynthia McKinney, and Nita Lowey. CARE aims to restore federal funding of abortion services for poor women and others using federally funded health care. The Freedom of Choice Act (FOCA) leaves abortion funding and parental involvement to the discretion of individual states. FOCA was characterized by Senator Carol Moseley-Braun, who withdrew her sponsorship of the bill, as not meeting the needs of the "marginalized, disrespected, and ignored population." 4 other Democratic women senators followed suit and promised to very strongly oppose all efforts to restrict abortions through amendments to appropriations bills. Senate appropriations bills were also considered during July. On July 15 the Senate Veterans Affairs (VA) Committee defeated an amendment that would have barred the use of federal funds for abortion services at VA hospitals, except in cases of rape, incest, or the saving of maternal life. Senate Committee members John Rockefeller and Tom Daschle contributed to the bill's defeat. Federal employee health insurance plans will continue to ban the coverage of abortion services due to passage by the Subcommittee on Treasury, Postal Service, and General Government. An amendment introduced by Senator Bond to allow abortions in cases of rape, incest, or risk to maternal life was adopted

  17. The extent of parasite-associated necrosis in the placenta and foetal tissues of cattle following Neospora caninum infection in early and late gestation correlates with foetal death.

    Gibney, E Helen; Kipar, Anja; Rosbottom, Anne; Guy, Catherine S; Smith, Robert F; Hetzel, Udo; Trees, Alexander J; Williams, Diana J L

    2008-04-01

    The protozoan parasite Neospora caninum is the most frequently diagnosed abortifacient in the UK and a leading cause of abortion worldwide but the mechanisms leading to abortion are not fully understood. The distribution of parasites and the histopathological changes in the placenta and foetus were compared in 12 cows following experimental infection of cattle with N. caninum in early (n=6) and late (n=6) gestation, by PCR, immunohistology, light microscopy and transmission electron microscopy. Twelve uninfected pregnant cattle were used as controls. Infection in early gestation led to foetal death. In the placentae of cattle immediately following foetal death, N. caninum DNA was detected and there was evidence of widespread parasite dissemination. This was associated with extensive focal epithelial necrosis, serum leakage and moderate maternal interstitial mononuclear cell infiltration. In the foetuses, parasites were evident in all tissues examined and were associated with necrosis. In the placenta of cattle infected in late gestation, N. caninum DNA was detected sporadically but parasites were not evident immunohistologically. Small foci of necrosis were seen associated with mild interstitial mononuclear cell infiltration. Detection of N. caninum DNA in the foetuses was sporadic and parasites were demonstrated immunohistologically in brain and spinal cord only, with an associated mononuclear cell infiltration. This data is consistent with uncontrolled parasite spread in an immunologically immature foetus and could, via multiparenchymal necrosis of foetal tissues or the widespread necrosis and inflammation observed in the placenta, be the cause of Neospora-associated abortions. PMID:18021783

  18. The role of T-cell-mediated mechanisms in virus infections of the nervous system.

    Dörries, R

    2001-01-01

    T lymphocytes play a decisive role in the course and clinical outcome of viral CNS infection. Summarizing the information presented in this review, the following sequence of events might occur during acute virus infection: After invasion of the host and a few initial rounds of replication, the virus reaches the CNS in most cases by hematogeneous spread. After passage through the BBB, CNS cells are infected and replication of virus in brain cells causes activation of the surrounding microglia population. Moreover, local production of IFN-alpha/beta induces expression of MHC antigens on CNS cells, and microglial cells start to phagocytose cellular debris, which accumulates as a result of virus-induced cytopathogenic effects. Upon phagocytosis, microglia becomes more activated; they up-regulate MHC molecules, acquire antigen presentation capabilities and secrete chemokines. This will initiate up-regulation of adhesion molecules on adjacent endothelial cells of the BBB. Transmigration of activated T lymphocytes through the BBB is followed by interaction with APC, presenting the appropriate peptides in the context of MHC antigens. It appears that CD8+ T lymphocytes are amongst the first mononuclear cells to arrive at the infected tissue. Without a doubt, their induction and attraction is deeply influenced by natural killer cells, which, after virus infection, secrete IFN-gamma, a cytokine that stimulates CD8+ T cells and diverts the immune response to a TH1-type CD4+ T cell-dominated response. Following the CD8+ T lymphocytes, tissue-penetrating, TH1 CD4+ T cells contact local APC. This results in a tremendous up-regulation of MHC molecules and secretion of more chemotactic and toxic substances. Consequently an increasing number of inflammatory cells, including macrophages/microglia and finally antibody-secreting plasma cells, are attracted to the site of virus infection. All trapped cells are mainly terminally differentiated cells that are going to enter apoptosis

  19. The perspective of rural physicians providing abortion in Canada: qualitative findings of the BC Abortion Providers Survey (BCAPS.

    Jennifer Dressler

    Full Text Available BACKGROUND: An increasing proportion of Canadian induced abortions are performed in large urban areas. For unknown reasons the number of rural abortion providers in Canadian provinces, such as British Columbia (BC, has declined substantially. This study explored the experiences of BC rural and urban physicians providing abortion services. METHODS: The mixed methods BC Abortion Providers Survey employed self-administered questionnaires, distributed to all known current and some past BC abortion providers in 2011. The optional semi-structured interviews are the focus of this analysis. Interview questions probed the experiences, facilitators and challenges faced by abortion providers, and their future intentions. Interviews were transcribed and analyzed using cross-case and thematic analysis. RESULTS: Twenty interviews were completed and transcribed, representing 13/27 (48.1% rural abortion providers, and 7/19 (36.8% of urban providers in BC. Emerging themes differed between urban and rural providers. Most urban providers worked within clinics and reported a supportive environment. Rural physicians, all providing surgical abortions within hospitals, reported challenging barriers to provision including operating room scheduling, anesthetist and nursing logistical issues, high demand for services, professional isolation, and scarcity of replacement abortion providers. Many rural providers identified a need to "fly under the radar" in their small community. DISCUSSION: This first study of experiences among rural and urban abortion providers in Canada identifies addressable challenges faced by rural physicians. Rural providers expressed a need for increased support from hospital administration and policy. Further challenges identified include a desire for continuing professional education opportunities, and for available replacement providers.

  20. Preface to Immune effector mechanisms in parasitic infections, a Discussion held at The Royal Society on the 19 and 20 February 1997.

    Liew, F. Y.; Vickerman, K.

    1997-01-01

    Preface to the published proceedings of Immune effector mechanisms in parasitic infections, a Discussion held at The Royal Society on the 19 and 20 February 1997, organized and edited by F. Y. Liew and K. Vickerman.