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Sample records for abortion spontaneous

  1. [Spontaneous abortion. Etiologic survey. Results].

    Baaklini, N; Anguenot, J L; Boulanger, J C; Vitse, M

    1990-12-01

    The definition of repeated spontaneous abortions is subject to caution. For some, it corresponds to at least three repeated spontaneous abortions with no normal previous pregnancy; for others, it comprises the repeated spontaneous abortions occurring after a normal pregnancy. It is a frequent problem, especially if one tries to give a wider definition. The authors studied the frequency of repeated spontaneous abortions in a continuous series of 14,857 pregnancies which took place between January 1982 and December 1988. In the study of the aetiology of the repeated spontaneous abortions in the various groups of women defined according to the number of previous pregnancies and abortions, they find the classical causes of repeated spontaneous abortions in all the categories: therefore, it seems legitimate to them that a wider definition be given for repeated spontaneous abortions. PMID:2291048

  2. The moral significance of spontaneous abortion.

    Murphy, T F

    1985-01-01

    Spontaneous abortion is rarely addressed in moral evaluations of abortion. Indeed, 'abortion' is virtually always taken to mean only induced abortion. After a brief review of medical aspects of spontaneous abortion, I attempt to articulate the moral implications of spontaneous abortion for the two poles of the abortion debate, the strong pro-abortion and the strong anti-abortion positions. I claim that spontaneous abortion has no moral relevance for strict pro-abortion positions but that the ...

  3. Pregnancy outcome following spontaneous abortions

    Swati Agrawal

    2015-12-01

    Conclusions: Previous history of spontaneous abortion is associated with adverse pregnancy outcome. There is increased risk of abortion, preterm delivery, need for caesarean sections and fetal loss in cases of previous spontaneous abortions. These complications and fetal loss can be reduced by booking the patients and giving due antenatal care. [Int J Reprod Contracept Obstet Gynecol 2015; 4(6.000: 1891-1893

  4. Kvinners reaksjoner etter spontan abort

    2012-01-01

    Background: Approximately 15 percent of all verified pregnancies end in miscarriage. It is known that spontaneous abortion often cause psychological distress. The women are at risk of suffering from grief, anxiety, depression and other psychological symptoms. Psychological symptoms could persist for years after the miscarriage and there is frequently no routine to identify psychiatric morbidity among the women. Research has been conducted to identify the consequences of abortion, but the stud...

  5. Spontaneous abortion and physical strain around implantation

    Hjollund, N H; Jensen, Tina Kold; Bonde, Jens Peter;

    2000-01-01

    Existing studies of physical strain and spontaneous abortion are mainly retrospective or based only on pregnancies that have survived the first trimester. Furthermore, almost all studies have relied on averaged measures of physical strain, which tend to blur an effect if peak values during short...... pregnancy the women recorded physical strain prospectively in a structured diary. Physical strain around the time of implantation was associated with later spontaneous abortion. The adjusted risk ratio for women who reported physical strain higher than average at day 6 to 9 after the estimated date of...

  6. Socioeconomic position and the risk of spontaneous abortion

    Norsker, Filippa Nyboe; Espenhain, Laura; A Rogvi, Sofie; Morgen, Camilla Schmidt; Andersen, Per Kragh; Andersen, Anne-Marie Nybo

    2012-01-01

    To investigate the relationship between different indicators of socioeconomic position and the risk of spontaneous abortion.......To investigate the relationship between different indicators of socioeconomic position and the risk of spontaneous abortion....

  7. Analysis of the Spontaneous Abortion in Chinese Married Women

    高尔生; 邓新清; 何更生; 方可娟; 唐威; 楼超华

    1994-01-01

    The spontaneous abortion is a common type of pregnant outcomes. The spontaneous abortion rate can be used to indicate the women's fecundity and the level of the reproductive health. It is also a sensitive indicator for determing the social, economic, and health status and prenatal care. To explore the preventive method for spontaneous abortion and improve women's health level, it is important to evaluate the status of spontaneous abortion and to determine the factors affecting

  8. Residential Exposure to Traffic and Spontaneous Abortion

    Green, Rochelle S; Malig, Brian; Windham, Gayle C.; Fenster, Laura; Ostro, Bart; Swan, Shanna

    2009-01-01

    Background Studies have shown associations between air pollution or traffic exposure and adverse birth outcomes, such as low birth weight. However, very few studies have examined the effect of traffic emissions on spontaneous abortion (SAB). Objective The goal of this study was to determine whether residential exposure to vehicular traffic was associated with SAB. Methods Pregnant women from a prepaid health plan in California were recruited into a prospective cohort study in 1990–1991. Three...

  9. ANTISPERM ANTIBODY IS A POSSIBLE CAUSE OF SPONTANEOUS ABORTION

    XUChong; CHENFu; LIULi; ZHAOFei-Sha

    1989-01-01

    To clarify the possible correlation between antisperm antibodies (ASA) and spontaneous abortion, 68 women, aged 23-37, experienced 2-9 times of spontaneous abortion were tested for ASA by ELISA. 38 fertile women, aged 24-40, without history of abortion were employed as control.

  10. Maternal smoking predicts the risk of spontaneous abortion

    Nielsen, Ann; Hannibal, Charlotte Gerd; Lindekilde, Bodil Eriksen;

    2006-01-01

    ) or who gave birth (n=1,578) during follow-up were selected. Associations between self-reported smoking at enrollment and subsequent spontaneous abortion were analyzed by means of multiple logistic regression. RESULTS: The risk of spontaneous abortion in relation to pre-pregnancy smoking showed a......BACKGROUND: Few studies have examined smoking prior to pregnancy and the occurrence of spontaneous abortion, as most studies have addressed the risk of spontaneous abortion in relation to smoking during pregnancy. However, results are not entirely consistent. The aim of the present study was to...... assess the risk of spontaneous abortion considering smoking prior to pregnancy. METHODS: We performed a nested case-control study using prospective data from a population-based cohort comprising 11,088 women aged 20-29 years. From this cohort, women who experienced either a spontaneous abortion (n=343...

  11. Q-feber som årsag til spontan abort

    Nielsen, Stine Yde; Mølbak, Kåre; Hjøllund, Niels Henrik

    2011-01-01

    Q-fever is a zoonotic infection. Pregnant women constitute a specific risk group as the infection may cause spontaneous abortion, intrauterine death, growth retardation, oligohydramnios and premature birth. A 39 year-old veterinarian had a spontaneous abortion in pregnancy week seven. During the...... first weeks of her pregnancy, she handled birth by-products from cows with Q-fever. The Q-fever titres revealed that she was most likely infected in very early pregnancy. According to the literature, infection in the first trimester constitutes a specific risk of spontaneous abortion....

  12. Cigarette, alcohol, and caffeine consumption: risk factors for spontaneous abortion

    Rasch, Vibeke

    2003-01-01

    OBJECTIVE: To study the association between cigarette, alcohol, and caffeine consumption and the occurrence of spontaneous abortion. METHODS: The study population consisted of 330 women with spontaneous abortion and 1168 pregnant women receiving antenatal care. A case-control design was utilized......; cases were defined as women with a spontaneous abortion in gestational week 6-16 and controls as women with a live fetus in gestational week 6-16. The variables studied comprise age, parity, occupational situation, cigarette, alcohol, and caffeine consumption. The association between cigarette, alcohol......, and caffeine consumption was studied using logistic regression analyzes while controlling for confounding variables. In addition stratified analyzes of the association between caffeine consumption and spontaneous abortion on the basis of cigarette and alcohol consumption were performed. RESULTS: Women...

  13. Cytogenetic analysis in 61 couples with spontaneous abortions

    江静; 傅曼芬; 王德芬

    2001-01-01

    Objective To examine the relationship between spontaneous abortion and chromosomal abnormalities. Methods Couples who had one or more consecutive spontaneous abortions and had normal genitals were enrolled for cytogenetic karyotype analysis. Results In the 61 couples, the detected incidence was 11.5%, with five Robertsonian translocations, one reciprocal translocation, and one pericentric inversion of chromosome 7. Conclusion Chromosomal abnormalities may play an important role in fetal wastage.

  14. Balanced Chromosomal Rearrangement in Recurrent Spontaneous Abortions: A Case Report

    Zarifian, Ahmadreza; Farhoodi, Zeinab; Amel, Roya; Mirzaee, Salmeh; Hassanzadeh-Nazarabadi, Mohammad

    2012-01-01

    One of the major causes of spontaneous abortion before the fourth month of pregnancy is chromosomal abnormalities. We report an unusual case of a familial balanced chromosomal translocation in a consanguineous couple who experienced 4 spontaneous abortions. Chromosomal studies were performed on the basis of G-banding technique at high resolution and revealed 46, XX, t (16; 6) (p12; q26) and 46, XY, t (16; 6) (p12; q26) in both partners, which induced such pregnancy complications. Chromosomal ...

  15. Expression of AIF-1 and RANTES in Unexplained Spontaneous Abortion and Possible Association with Alloimmune Abortion

    Yong-hong LI; Hai-lin WANG; Ya-juan ZHANG

    2007-01-01

    Objective To investigate the effects of allograft inflammatory factor-1(AIF-1)and (RANTES) in sera and deciduas on unexplained early spontaneous abortion.Methods AIF-1 and RANTES were examined in sera and deciduas/endometria of 43 unexplained early spontaneous abortion women (group A),40 healthy women with early pregnancy(group B)and 20 healthy women with no pregnancy (group C). Immunohistochemistry and enzyme linked immunosorbent assay (ELISA) were used in this study. Results AIF-1 protein was expressed both in deciduas of group A and in endometria of group C.In group A, H scores in the recurrent abortion deciduas specimens were significantly greater than those in the first abortion;in endometrium,expression of AIF-1 was greater in the secretory than in proliferative phase of group C.In group B,concentrations of RANTES in sera were higher in 7th-8th week of pregnancy than in 6th-7th and >8th week of pregnancy;expression of AIF-1 protein showed a negative correlation with RASNTES concentration;a significant increase of the RANTES levels in sera and tissue was observed in group B. Conclusion These results demonstrate, for the first time,that AIF-1 are expressed in deciduas of unexplained spontaneous abortion suggesting that AIF-1 involve in alloimmune abortion; RANTES might act as a novel blocking antibody;AIF-1 and RANTES might act as reliable markers for diagnosis of early alloimmune abortion.

  16. Cigarette, alcohol, and caffeine consumption: risk factors for spontaneous abortion

    Rasch, Vibeke

    2003-01-01

    , and caffeine consumption was studied using logistic regression analyzes while controlling for confounding variables. In addition stratified analyzes of the association between caffeine consumption and spontaneous abortion on the basis of cigarette and alcohol consumption were performed. RESULTS: Women...... 375 mg or more caffeine per day were 4.84 (2.87-8.16) and 2.21 (1.53-3.18), respectively. Women who smoked 10-19 cigarettes and 20 or more cigarettes per day did not have significantly increased ORs for having spontaneous abortions, after adjusting for other risk factors. CONCLUSION: Consumption of 5...... or more units alcohol per week and 375 mg or more caffeine per day during pregnancy may increase the risk of spontaneous abortion....

  17. HLA-G polymorphisms in couples with recurrent spontaneous abortions

    Hviid, T V; Hylenius, S; Hoegh, A M;

    2002-01-01

    The etiology of a fraction of recurrent spontaneous abortions (RSA) may involve immunological mechanisms. Aberrant profiles of Th1 and Th2 cytokines have been observed which are not present in uncomplicated pregnancies. Studies of classical HLA class I and II antigens in relation to RSA have not...... been conclusive. Furthermore, these antigens are not expressed in the placenta with the exception of HLA-C. However, HLA-G is expressed on especially invasive cytotrophoblasts and exists in both membrane and soluble forms. HLA-G may be involved in materno-fetal tolerance. Therefore, 61 RSA couples...... (with three or more spontaneous abortions) and 47 fertile control couples were HLA-G genotyped by direct DNA sequencing and analyzed for specific polymorphisms. No statistically significant differences were observed in the distribution of HLA-G alleles between controls and RSA couples, however, 15% of...

  18. Hypothyrodisim and spontaneous abortions among Hanford, Washington, downwinders

    Grossman, C.M.; Morton, W.E. [Oregon Health Sciences Univ., Portland, OR (United States); Nussbaum, R.H. [Portland State Univ., Portland, OR (United States)

    1996-05-01

    Spontaneous abortions occurred more than twice as frequently in hypothyroid women, compared with nonhypothyroid women. Both groups of women had lived in the same environment during the same period of time. The high incidence of hypothyroidism in a cohort of several hundred women who lived downwind of the Hanford, Washington, nuclear installation was likely associated with environmental contamination from deliberate releases of radioactive iodine from the facility. 8 refs.

  19. SEROPREVALENCE OF TOXOPLASMA GONDII IN SPONTANEOUS ABORTIONS IN PREGNANT WOMEN

    Anubhuti

    2015-05-01

    Full Text Available INTRODUCTION: Toxoplasmosis is one of the diseases comprising the TORCH [ Toxoplasma gondii , Rubella virus , Cytomegalovirus , Herpes simplex virus] infections . It is known to cause perinatal death if the organism is acquired during pregnancy . Toxoplasmosis during pregnancy can cause congenital infection which may result in mental retardation and blindness in the infant . The present study aimed to evaluate the seroprevalence of Toxoplasma gondii and it i s associated risk facto rs among the women with history of spontaneous abortion . MATERIALS & METHODS: A total of 60 women with past or present history of spontaneous abortion and another 60 pregnant women without any bad obstetric history as control attending our hospital were in cluded in the study . All the serum samples were tested for the presence of specific Toxoplasma IgM and IgG antibodies using the On Site Toxo IgG/IgM Rapid Test strip , a lateral flow chromatographic immunoassay . RESULTS: Total seroprevalence of Toxoplasma gondii in the study was 12 . 5% . Total seropositivity in women with history of spontaneous abortion was 12 ( 20% and 3 ( 5% among control group . More number of seropositivity was observed among women between 26 to 30 years ( 60% . Risk factor of having cat a s pet animal had greater association of getting toxoplasmosis . CONCLUSION: This study revealed that the seroprevalence of toxoplasmosis was significantly high in the study population than in control group . There should be routine screening for antenatal wo men with bad obstetric history .

  20. Alcohol consumption at the time of conception and spontaneous abortion

    Henriksen, Tine Brink; Hjollund, Niels Henrik; Jensen, Tina Kold;

    2004-01-01

    The authors studied the association between female and male alcohol intakes at the time of conception and the risk of spontaneous abortion, including early pregnancy loss detected by urinary human chorionic gonadotropin. After a nationwide mailing to about 50,000 members of four trade unions in D...... intake were statistically significant. Both male and female alcohol intakes during the week of conception increased the risk of early pregnancy loss.......The authors studied the association between female and male alcohol intakes at the time of conception and the risk of spontaneous abortion, including early pregnancy loss detected by urinary human chorionic gonadotropin. After a nationwide mailing to about 50,000 members of four trade unions in...... conception and the adjustment factors, female alcohol intake was associated with 2-3 times the adjusted risk of spontaneous abortion compared with no intake, and male alcohol intake was associated with 2-5 times the adjusted risk. Only the adjusted relative risks for 10 or more drinks/week compared with no...

  1. Alcohol consumption at the time of conception and spontaneous abortion.

    Henriksen, Tine Brink; Hjollund, Niels Henrik; Jensen, Tina Kold; Bonde, Jens Peter; Andersson, Anna-Maria; Kolstad, Henrik; Ernst, Erik; Giwercman, Aleksander; Skakkebaek, Niels Erik; Olsen, Jørn

    2004-10-01

    The authors studied the association between female and male alcohol intakes at the time of conception and the risk of spontaneous abortion, including early pregnancy loss detected by urinary human chorionic gonadotropin. After a nationwide mailing to about 50,000 members of four trade unions in Denmark in 1992-1994, 430 couples without previous pregnancy attempts were enrolled when birth control was discontinued, and they were followed until a clinically recognized pregnancy or for six menstrual cycles. Alcohol intake and potential confounding factors were reported in monthly questionnaires. Women collected morning urine for 10 days from the first day of vaginal bleeding in each cycle. The authors detected 186 pregnancies: 131 resulted in childbirth, and 55 resulted in spontaneous abortion (34 detected by urinary human chorionic gonadotropin). Depending on the intake in the cycle of conception and the adjustment factors, female alcohol intake was associated with 2-3 times the adjusted risk of spontaneous abortion compared with no intake, and male alcohol intake was associated with 2-5 times the adjusted risk. Only the adjusted relative risks for 10 or more drinks/week compared with no intake were statistically significant. Both male and female alcohol intakes during the week of conception increased the risk of early pregnancy loss. PMID:15383410

  2. Factors Analysis of Spontaneous Abortion after Thawed-vitrified Blastocysts Transfer

    Dong YANG; Zheng-yi SUN; Cheng-yan DENG; Qi YU; Fang-fang HE

    2008-01-01

    Objective To investigate the factors resulting in spontaneous abortion after transferring frozen-thawing blastocysts. Methods A total of 108 cases transferring vitrified blastocysts were divided into two groups: abortion group (n =20) and ongoing group (n=88). Cytogenetic analysis of apoblemas was performed in 12 cases of the abortion.Results The overall spontaneous abortion rate was 18.50%(20/108) and the early spontaneous rate was 16.67%(18/108). ,4 significant difference in maternal age was observed (abortion group: 33.3±4.0 years, ongoing group: 31.0±3.6 years, P=0.02). No difference in other parameters was found. Cytogenetic analysis of apoblemas was obtained for 12 cases, and 2 specimens were contaminated. Seven of ten patients had abnormal karyotypes. Conclusion The underlying cause of spontaneous abortion after transferring frozen thawing blastocysts appears to be abnormal karyotypes.Advancing maternal age seems to increase the risk of spontaneous abortion.

  3. Endocrine dysfunction and recurrent spontaneous abortion: An overview.

    Kaur, Ramandeep; Gupta, Kapil

    2016-01-01

    Miscarriage is the spontaneous loss of a fetus before it is viable, occurring at a rate of 15-20%. Recurrent spontaneous abortion (RSA) or habitual miscarriage is defined as repeated occurrence of 3 or more miscarriages before 20(th) week of gestation accounting for the most common complication of early pregnancy in humans. Various etiological factors responsible for recurrent miscarriage are anatomical, genetical, endocrinological, immunological, and infectious. The endocrinological abnormalities may be polycystic ovarian syndrome, hyperprolactinemia, luteal phase defect, thyroid dysfunction, diabetes, or hyperandrogenism contributing to recurrent pregnancy loss. In the present article, the role of endocrinological disorders in patients with RSA has been reviewed. The article search was done using electronic databases, Google scholarly articles, and PubMed based on different key words. We have further combined the searches and made grouping as per various endocrine abnormalities, which might be responsible to cause spontaneous loss of fetus. PMID:27127734

  4. Endocrine dysfunction and recurrent spontaneous abortion: An overview

    Kaur, Ramandeep; Gupta, Kapil

    2016-01-01

    Miscarriage is the spontaneous loss of a fetus before it is viable, occurring at a rate of 15–20%. Recurrent spontaneous abortion (RSA) or habitual miscarriage is defined as repeated occurrence of 3 or more miscarriages before 20th week of gestation accounting for the most common complication of early pregnancy in humans. Various etiological factors responsible for recurrent miscarriage are anatomical, genetical, endocrinological, immunological, and infectious. The endocrinological abnormalities may be polycystic ovarian syndrome, hyperprolactinemia, luteal phase defect, thyroid dysfunction, diabetes, or hyperandrogenism contributing to recurrent pregnancy loss. In the present article, the role of endocrinological disorders in patients with RSA has been reviewed. The article search was done using electronic databases, Google scholarly articles, and PubMed based on different key words. We have further combined the searches and made grouping as per various endocrine abnormalities, which might be responsible to cause spontaneous loss of fetus. PMID:27127734

  5. Maternal underweight and the risk of spontaneous abortion

    Helgstrand, Stine; Andersen, Anne-Marie Nybo

    2005-01-01

    DNBC from October 1, 1997 to March 31, 1999 and interviewed subsequently. The pregnant women were recruited in first half of pregnancy and interviewed about pre-pregnant body size, obstetric history, exposures in pregnancy, and socio-demographic factors. Pregnancies were followed-up regarding......% confidence limits 0.95-1.63) compared to women with pre-pregnant BMI 18.5-24.9. Women with a BMI of 25 or more had a smaller increase in risk of spontaneous abortion. Adjustment for maternal age, parity, previous miscarriages, and lifestyle factors did not affect the estimates substantially, neither did...

  6. Fatal Disseminated Tuberculous Peritonitis following Spontaneous Abortion: A Case Report

    Munire Erman Akar

    2014-01-01

    Full Text Available We describe a rare case of fatal disseminated tuberculous peritonitis in a young woman with rapid progressive clinical course following spontaneous abortion of 20-week gestation. Clinical and laboratory findings were initially unremarkable. She underwent diagnostic laparoscopy which revealed numerous tiny implants on the peritoneum and viscera. Histopathology showed chronic caseating granulomas, and the tissue culture grew Mycobacterium tuberculosis. At fifth day of the antituberculous treatment multiorgan failure occurred in terms of pulmonary, hepatic, and renal insufficiency. She developed refractory metabolic acidosis with coagulopathy and pancytopenia, and she died of acute respiratory distress syndrome and septic shock on her twelfth day of hospitalization.

  7. Spontaneous abortion: a prospective cohort study of younger women from the general population in Denmark. Validation, occurrence and risk determinants

    Buss, L; Tolstrup, J; Munk, C; Bergholt, T; Ottesen, B; Grønbaek, M; Kjær, S. K.

    2006-01-01

    abortions identified from both sources were recorded in the same year. During follow-up a total of 20.9% of pregnancies intended to be carried to term ended as a spontaneous abortion. In the risk factor analysis, we found that previous spontaneous abortion, being single, never having used oral......OBJECTIVE: To assess the occurrence of spontaneous abortion, comparing two different data sources. To estimate the rate of spontaneous abortion over a 2-year period, and examine potential predictors of the risk for incident spontaneous abortion. METHODS: We used interview data from a population......-year follow-up. Finally, risk determinants for incident spontaneous abortion were analyzed by means of logistic regression. RESULTS: A total of 654 spontaneous abortions before enrolment in the study were reported by the women compared to 531 abortions found in the register. More than 80% of the spontaneous...

  8. Male-mediated spontaneous abortion among spouses of stainless steel welders

    Hjollund, N H; Bonde, J P; Jensen, T K;

    2000-01-01

    Male-mediated spontaneous abortion has never been documented for humans. The welding of stainless steel is associated with the pulmonary absorption of hexavalent chromium, which has genotoxic effects on germ cells in rodents. Clinical and early subclinical spontaneous abortions were examined among...... spouses of stainless-steel welders....

  9. Male-mediated spontaneous abortion among spouses of stainless steel welders

    Hjollund, N H; Bonde, Jens Peter; Jensen, Tina Kold;

    2000-01-01

    Male-mediated spontaneous abortion has never been documented for humans. The welding of stainless steel is associated with the pulmonary absorption of hexavalent chromium, which has genotoxic effects on germ cells in rodents. Clinical and early subclinical spontaneous abortions were examined among...

  10. Balanced Chromosomal Translocation of Chromosomes 6 and 7: A Rare Male Factor of Spontaneous Abortions

    Resim, Sefa; Kadıoğlu, Ateş; Akman, Tolga; Bayrak, Ayşe Gül; Efe, Erkan

    2013-01-01

    Background: Carriers of structural chromosomal rearrangements such as Robertsonian or reciprocal translocations have an increased risk of spontaneous abortion and producing offspring with genetic abnormalities. Case Report: We report a man with balanced chromosomal translocations located at 6p22, and 7q22. His wife has a history of four spontaneous abortions. Conclusion: Couples with a history of abortions should be investigated cytogenetically, after other causes of mis...

  11. Male Factors and socioeconomic indicators correlate with the risk of spontaneous abortion

    Olsen, Jørn; Basso, Olga; Christensen, Kaare

    1999-01-01

    No less than 10% of clinically recognised pregnancies end as spontaneous abortions and the recurrence risk is high. Due to lack of data and appropriate study design only little is known about preventable causes of miscarriage. The aim of this study was to estimate the effect of paternal and...... personal identification numbers and information stored in several population registers. Change of partner reduced the recurrence risk of spontaneous abortion substantially (OR = 0.59; 95 CI 0.52-0.67), but also changes in social status or job reduced the recurrence risk significantly. Changing the...... municipality of residence to a low risk area (based upon the geographical distribution of spontaneous abortions) reduced the risk of spontaneous abortion in both cohorts. A paternal effect on the recurrence risk of spontaneous abortion cannot be ruled out but environmental factors also play a role....

  12. Spontaneous Abortion and a Diet Drug Containing Caffeine and Ephedrine

    Howards, Penelope P; Hertz-Picciotto, Irva; Bech, Bodil H;

    2012-01-01

    BACKGROUND: Medications may be consumed periconceptionally before a woman knows she is pregnant. In this study, the authors evaluate the association of a prescription diet drug (Letigen) containing ephedrine (20 mg) and caffeine (200 mg) with spontaneous abortion (SAB) in the Danish National Birth...... pregnancy Letigen use on SAB. PRINCIPAL FINDINGS: The estimated maternal age-adjusted hazard ratio for SAB was 1.1 (95% confidence interval 0.8-1.6) for any periconceptional Letigen use compared to no periconceptional use. CONCLUSIONS: Although Letigen has high levels of caffeine (the recommended 3 pills....../day are approximately equivalent to caffeine from 6 cups of coffee), periconceptional use does not appear to be associated with an appreciably increased hazard of clinically recognized SAB....

  13. Increase of tumor necrosis factor receptor 1 expression in women with unexplained early spontaneous abortion

    YAN Chun-fang; YU Xue-wen; JIN Hui; LI Xu

    2004-01-01

    To investigate membrane tumor necrosis factor receptor 1 protein expression level in decidua andconcentration of soluble tumor necrosis factor receptor 1 in serum in women with unexplained early spontaneous abortion,threatened abortion, and compare the levels with healthy pregnant women. Methods: Thirty-seven women with unexplainedearly spontaneous abortion, 27 women with threatened abortion, and 34 healthy pregnant women undergoing artificial abortionof pregnancy at 6 - 10 weeks of gestation were selected. Decidual samples were collected when women were undergoing arti-ficial abortion, and blood samples were collected at the same time. The level of membrane tumor necrosis factor receptor 1 indecidua was detected by flow cytometer, and the concentration of soluble tumor necrosis factor receptor 1 in sera was mea-sured with an enzyme-linked immunosorbent assay. Results: The ercentages of membrane tumor necrosis factor receptor 1positive decidual cells were 16.42 ± 7.10 Mean ± SD for women with unexplained early spontaneous abortion and 13.14 ±6.30 for healthy pregnant women ( P < 0.05). Serum oncentration of soluble tumor necrosis factor receptor 1 was signifi-cantly higher in women with unexplained early spontaneous abortion than in healthy pregnant women and in women withthreatened abortion, and no difference was found between healthy pregnant women and women with threatened abortion.Conclusion: Women with unexplained early spontaneous abortion present significantly higher expression of tumor necrosisfactor receptor 1 than healthy pregnant women, suggesting that over-expression of tumor necrosis factor receptor 1 may cont-ribute to the development of early spontaneous abortion.

  14. REPLICATION OF STUDY ON SPONTANEOUS ABORTION AND DISINFECTION BY-PRODUCT (DBP) EXPOSURES

    A limited number of epidemiological studies have evaluated the potential association between exposure to disinfection byproducts (DBPs) in drinking water and adverse reproductive outcomes. Reproductive effects that have been reported include spontaneous abortions, congenital defe...

  15. Use of mobile phone during pregnancy and the risk of spontaneous abortion

    Mahmoudabadi, Fatemeh Shamsi; Ziaei, Saeideh; Firoozabadi, Mohammad; Kazemnejad, Anoshirvan

    2015-01-01

    Background Exposure to electromagnetic fields of cell phones increasingly occurs, but the potential influence on spontaneous abortion has not been thoroughly investigated. Methods In a case–control study, 292 women who had an unexplained spontaneous abortion at  14 weeks gestation were enrolled. Two data collection forms were completed; one was used to collect data about socioeconomic and obstetric characteristics, medical and reproductive history, and lifestyles. Another was used to collect ...

  16. Prenatal antidepressant exposure and risk of spontaneous abortion - a population-based study.

    Maiken Ina Siegismund Kjaersgaard

    Full Text Available PURPOSE: To estimate the risk of spontaneous abortion after use of antidepressant medication during pregnancy. METHODS: From the Danish Medical Birth Registry and the Danish National Hospital Registry, we identified all pregnancies leading to in- or outpatient contacts in Denmark from February 1997 to December 2008. The Danish Registry of Medicinal Product Statistics provided information on the women's prescriptions for antidepressants during pregnancy. We obtained information on women who were diagnosed with depression from the Danish Psychiatric Central Registry. Adjusted relative risks (aRR of spontaneous abortion were estimated according to exposure to antidepressants or maternal depression using binomial regression. RESULTS: Of the 1,005,319 pregnancies (547,300 women identified, 114,721 (11.4% ended in a spontaneous abortion. We identified 22,061 pregnancies exposed to antidepressants and 1,843 with a diagnosis of depression with no antidepressant use, of which 2,637 (12.0% and 205 (11.1% ended in a spontaneous abortion, respectively. Antidepressant exposure was associated with an aRR of 1.14 (95% confidence interval (CI 1.10-1.18 for spontaneous abortion compared with no exposure to antidepressants. Among women with a diagnosis of depression, the aRR for spontaneous abortion after any antidepressant exposure was 1.00 (95% CI 0.80-1.24. No individual selective serotonin reuptake inhibitor (SSRI was associated with spontaneous abortions. In unadjusted analyses, we found that mirtazapine, venlafaxine, and duloxetine were associated with spontaneous abortions among women with depression but we had no information on potential differences in disease severity and only few pregnancies were exposed in the population. CONCLUSION: We identified a slightly increased risk of spontaneous abortion associated with the use of antidepressants during pregnancy. However, among women with a diagnosis of depression, antidepressants in general or individual

  17. Robertsonian translocation between chromosomes (no.21/14) in relation to the history of spontaneous abortion in a family

    Mohammad Hasanzadeh-NazarAbadi; Fatemeh Baghbani; Iman Namazi; Salmeh Mirzaee

    2014-01-01

    Background: Approximately 205 million pregnancies occur each year in the worldwide. On the other hand, Spontaneous abortion has been reported in 15-20% of all diagnosed pregnancies. The most common cause of spontaneous abortion is chromosomal abnormalities of the embryo. Robertsonian translocation carriers specially 21-14 are the most common balanced rearrangement among the carrier couples with the history of spontaneous abortion. In order to search for balanced chromosomal rearrangement and ...

  18. Racial variation in the number of spontaneous abortions before a first successful pregnancy, and effects on subsequent pregnancies

    Oliver-Williams, Clare T.; Steer, Philip J

    2015-01-01

    Objective To assess the relationship between race and spontaneous abortion, whether the relationship varies by risk factors, and the effect of spontaneous abortions on subsequent pregnancies. Methods A retrospective study was undertaken using data collected in London, UK, between 1988 and 2000. Logistic regression evaluated histories of spontaneous abortion and associations with small-for-gestational-age and preterm births in black African, black Caribbean, and South Asian women relative to w...

  19. Immunoexpression of CD30 and CD30 ligand in deciduas from spontaneous abortions

    M Trovato

    2009-06-01

    Full Text Available In the present study, using immunohistochemistry, we studied the expression of CD30 and CD30-L in 35 deciduas obtained from women following elective abortion during normal physiological gestation and in 60 deciduas obtained from women after spontaneous abortion with or without signs of inflammation. The main difference was noticed in the first trimester of gestation in which was found a decrease in CD30/CD30-L-positive decidual glandular and stromal cells in a greater number of cases of spontaneous abortions with respect to cases of physiological pregnancies (70% vs 50%, p<0.05. In addition, deciduas from spontaneous abortions with inflammation and without inflammation reacted similarly. The reduced expression of CD30 and CD30-L and their cellular pattern detected in the deciduas from spontaneous abortions suggest that the CD30/CD30-L system is crucial for preventing abortions in the first trimester. And furthermore, the distinctive expression of CD30/CD30- L in deciduas from physiological pregnancies may indicate that the CD30/CD30-L system exerts its main role in the first trimester.

  20. Chromosomal abnormalities in spontaneous abortion after assisted reproductive treatment

    Kim You

    2010-11-01

    Full Text Available Abstract Background We evaluated cytogenetic results occurring with first trimester pregnancy loss, and assessed the type and frequency of chromosomal abnormalities after assisted reproductive treatment (ART and compared them with a control group. We also compared the rate of chromosomal abnormalities according to infertility causes in ICSI group. Methods A retrospective cohort analysis was made of all patients who were referred to the Genetics Laboratory of Fertility Center of CHA Gangnam Medical Center from 2005 to 2009 because of clinical abortion with a subsequent dilation and evacuation (D&E performed, and patients were grouped by type of conception as follows: conventional IVF (in vitro fertilization (n = 114, ICSI (intracytoplasmic sperm injection (n = 140, and control (natural conception or intrauterine insemination [IUI] (n = 128. Statistical analysis was performed using SPSS software. Results A total 406 specimens were referred to laboratory, ten abortuses were excluded, and in 14 cases, we did not get any spontaneous metaphase, chromosomal constitutions of 382 specimens were successfully obtained with conventional cytogenetic methods. Overall, 52.62% of the miscarriages were found to be cytogenetically abnormal among all patients, the frequency was 48.4% in the control group, 54.3% of miscarriages after ICSI and 55.3% after conventional IVF (p = 0.503. The most prevalent abnormalities were autosomal trisomy, however, nine (11.69% sex chromosome aneuploidy were noted in the ICSI group vs. four (6.45% and two (3.23% cases in the conventional IVF group and control group. We compared chromosomal abnormalities of miscarriages after ICSI according to infertility factor. 55.71% underwent ICSI due to male factors, 44.29% due to non-male factors. ICSI group having male factors showed significantly higher risk of chromosomal abnormalities than ICSI group having non-male factors (65.8% vs. 34.2%, p = 0.009, odds ratio = 1.529, 95% CI = 1

  1. Assessment of Relationship between Spontaneous Abortion and Occupational Exposure to Organic Solvents

    S Mohammadi

    2011-04-01

    Full Text Available Introduction & Objective: Nowadays, some studies indicate the adverse effects of exposure to chemicals, especially organic solvents on the reproductive system of females. This study aimed to assess the relationship between spontaneous abortion with occupational exposure to organic solvents in pharmaceutical industry. Materials & Methods: This is a cross-sectional and descriptive-analytical study which was carried out in 2010 in one of the pharmaceutical factories located in the suburbs of Tehran. During the study, married women who were working in the factory laboratory units and were exposed to mixed organic solvents were compared with married women who were working in the packing units of the factory without occupational exposure to organic solvents. Frequency of spontaneous abortion and duration of pregnancy were assessed in both two groups. Collected data were analyzed with the SPSS software using t-test, logistic regression, and chi-square test. Results: In the present study, the frequency of spontaneous abortion in employees with exposure to organic solvents mixture was 10.7%. This study showed that even after adjustment for confounding factors, there was a significant correlation between spontaneous abortion and occupational exposure to organic solvents mixture and this correlation increased with increasing levels of exposure to organic solvents. Moreover, a significant correlation was observed between occupational exposure to mixed organic solvents and waiting time to become pregnant (TTP. Furthermore, this study showed that even after adjustment for confounding variables, shift workers were significantly more affected by spontaneous abortion compared to daytime workers (P < 0.001. Conclusion: According to the results of this study, since there is probability of spontaneous abortion resulting from occupational exposure to various chemicals including organic solvents, review of the status of occupational exposure of workers can be helpful

  2. Association of Histophilus somni with spontaneous abortions in dairy cattle herds from Brazil.

    Headley, Selwyn Arlington; Voltarelli, Daniele; de Oliveira, Victor Henrique Silva; Bronkhorst, Dalton Evert; Alfieri, Alice Fernandes; Filho, Luiz Carlos Negri; Okano, Werner; Alfieri, Amauri Alcindo

    2015-02-01

    This study investigated the participation of infectious agents in spontaneous abortions and reproductive problems at eight dairy cattle herds from three geographical regions of Brazil. Fourteen aborted fetuses and the organ sections of one cow with history of repeated abortions were received for pathological evaluations and molecular diagnostics. PCR/RT-PCR assays targeted specific genes of abortifacient agents of cattle: bovine viral diarrhea virus (BVDV), bovine herpesvirus 1 (BoHV-1), Listeria monocytogenes, Neospora caninum, Leptospira spp., Brucella abortus, and Histophilus somni. Six fetuses were adequate for pathological investigations; one of these did not demonstrate remarkable pathological alterations. Significant histopathological findings included vasculitis, hemorrhage, and fibrinous thrombosis of the cerebrum (n = 4); necrotizing myocarditis (n = 3); and hemorrhagic enteritis (n = 3). The placenta and uterus of the cow as well as the kidney, pancreas, and liver of her aborted fetus contained H. somni DNA and demonstrated histopathological evidence of histophilosis. All fetuses contained H. somni DNA in multiple organs. Coinfections of H. somni with B. abortus (n = 2), N. caninum (n = 2), BVDV (n = 1), and BoHV-1 (n = 1) were identified; two fetuses demonstrated three pathogens. These findings suggest that H. somni was associated with the spontaneous abortions and reproductive problems of these herds. However, the exact cause of fetal death might not be attributed only to H. somni in all aborted fetuses, since some of these were infected with other abortifacient agents. PMID:25480485

  3. Prevention of recurrent spontaneous abortions by leukocyte transfusions.

    Taylor, C G; Faulk, W P; McIntyre, J A

    1985-08-01

    One hundred and thirty-nine couples referred because of recurrent abortions with no obvious cause were assessed for genetic similarity using the HLA major histocompatibility system. Comparison with 103 fertile control couples demonstrated that a much higher proportion of couples in the abortion group shared two or more HLA antigens. Using this criterion, 44 wives out of the 139 couples referred, when compared with a child-bearing group, appeared to share a greater than expected number of histocompatibility antigens and were therefore considered suitable for treatment. Twenty-eight wives have received treatment with white cell infusions from erythrocyte-compatible donors and so far they have delivered 17 babies plus 2 second babies. Another 3 wives are pregnant beyond their previous dates for abortions (1 first and 2 second pregnancies). There have been 5 failures (4 first pregnancy and 1 second pregnancy); one of these was treated a second time and has now successfully delivered. Seven couples are awaiting conception. Of the patients who have become pregnant, 81.5% have had successful deliveries. No adverse transfusion reactions have been observed. PMID:4020795

  4. Trends in Self-reported Spontaneous Abortions: 1970–2000

    Lang, Kevin; Nuevo-Chiquero, Ana

    2012-01-01

    Little is known about how the miscarriage rate has changed over the past few decades in the United States. Data from Cycles IV to VI of the National Survey of Family Growth (NSFG) were used to examine trends from 1970 to 2000. After accounting for abortion availability and the characteristics of pregnant women, the rate of reported miscarriages increased by about 1.0% per year. This upward trend is strongest in the first seven weeks and absent after 12 weeks of pregnancy. African American and...

  5. Abortion

    An abortion is a procedure to end a pregnancy. It uses medicine or surgery to remove the embryo or ... personal. If you are thinking of having an abortion, most healthcare providers advise counseling.

  6. Abortion.

    1993-09-01

    Vacuum aspiration, dilatation and curettage, hysterotomy, and, in some cases, hysterectomy comprise surgical methods of abortion. Oral administration of RU-486, epostane, prostaglandins E and F2 and vaginal suppositories of prostaglandins E and F2 are medical abortion methods. The traditional or clandestine methods are usually performed by unqualified persons and pregnant women themselves. These methods tend to be inefficient and harmful. They include oral preparations of herbs and drugs (e.g., quinine and ergot), introduction of fluids (e.g., household disinfectants) into the vagina, introduction of foreign bodies (e.g., twigs, stems, hollow tubes, needles, wire) into the uterus. Hospital records, death certificates, and community-based surveys are common sources of data on abortion. Worldwide, 40-70/1000 women of childbearing age undergo an abortion. 20-33% of all pregnancies are terminated. Abortion is always legal when it is performed to save a pregnant woman's life. In most countries, it is legal to protect the woman's physical or mental health against serious danger. The risk of death from a legal abortion is rare. On the other hand, when an abortion is performed by an unqualified, unskilled abortionist and/or under unhygienic conditions (all of which are common in countries who have a law against abortion) the risk of death is much higher. In fact, abortion is one of the leading causes of maternal death in many countries (25% and 86% of maternal deaths in Bangladesh and Romania, respectively). Common complications of abortion are incomplete abortion, trauma to pelvic organs (e.g., uterine perforation), tetanus, and infertility. In some developing countries, the cost of treating abortion complications account for up to 50% of maternity hospital budgets. Ways to reduce mortality from unsafe abortion include promoting contraceptive use, legalizing abortion, allowing trained practitioners to perform abortions for health reasons, and improving clinical management

  7. The Expressions of P53, MDM2 in Trophoblasts of Spontaneous Abortion Mouse Model and the Relevant Researches

    Chunlan Zhou; Qian Wang; Menghuan Zeng; Liping Cheng; Xiaoyun Xie

    2013-01-01

    Objective: To explore the mRNA expression of the related genes of p53, MDM2, vascular endothelial growth factor (VEGF) and hypoxia inducible transcription factors-1 a (HIF-la) in villous samples of spontaneous abortion mouse models and normal pregnancy models, and to discuss the effect of p53, MDM2 on the growth of villous trophoblast cells. Methods: The abortion-prone CBAXDBA/2 matings were established as the model of spontaneous abortion and the non-abortion-prone CBA...

  8. Triclosan causes spontaneous abortion accompanied by decline of estrogen sulfotransferase activity in humans and mice

    Wang, Xiaoli; Chen, Xiaojiao; Feng, Xuejiao; Chang, Fei; Chen, Minjian; Xia, Yankai; Chen, Ling

    2015-01-01

    Triclosan (TCS), an antibacterial agent, is identified in serum and urine of humans. Here, we show that the level of urinary TCS in 28.3% patients who had spontaneous abortion in mid-gestation were increased by 11.3-fold (high-TCS) compared with normal pregnancies. Oral administration of TCS (10 mg/kg/day) in mice (TCS mice) caused an equivalent urinary TCS level as those in the high-TCS abortion patients. The TCS-exposure from gestation day (GD) 5.5 caused dose-dependently fetal death during GD12.5–16.5 with decline of live fetal weight. GD15.5 TCS mice appeared placental thrombus and tissue necrosis with enhancement of platelet aggregation. The levels of placenta and plasma estrogen sulfotransferase (EST) mRNA and protein in TCS mice or high-TCS abortion patients were not altered, but their EST activities were significantly reduced compared to controls. Although the levels of serum estrogen (E2) in TCS mice and high-TCS abortion patients had no difference from controls, their ratio of sulfo-conjugated E2 and unconjugated E2 was reduced. The estrogen receptor antagonist ICI-182,780 prevented the enhanced platelet aggregation and placental thrombosis and attenuated the fetal death in TCS mice. The findings indicate that TCS-exposure might cause spontaneous abortion probably through inhibition of EST activity to produce placental thrombosis. PMID:26666354

  9. The Liver X Receptor in Correlation with Other Nuclear Receptors in Spontaneous and Recurrent Abortions

    Julia Knabl

    2013-01-01

    Full Text Available The liver X receptors (LXRs have been shown to be crucially involved in maternal-fetal cholesterol transport and placentation. The aim of this study was to investigate the expression pattern and frequency of LXR under normal physiological circumstances and in spontaneous abortion and/or recurrent miscarriage. A total of 29 (12 physiologic pregnancies/10 spontaneous abortions/7 recurrent miscarriages human pregnancies in first trimester were analysed for LXR expression. Expression changes were evaluated by immunohistochemistry for receptor and quantitative RT-PCR (TaqMan was performed to determine the level of LXR mRNA expression. We also stained for RXRα and PPARγ as possible heterodimers of LXR. LXR expression was downregulated in the syncytiotrophoblast of spontaneous abortion placentas compared to normal pregnancy. In recurrent miscarriage there was a trend for a downregulation. Decidua showed an even stronger downregulation in both groups. In the syncytiotrophoblast we found a positive correlation for the combination of LXR/PPARγ in abortions and a negative correlation for LXR/RXRα. In addition, double-immunofluorescence staining showed that LXR as well as RXRα and PPARγ are expressed by the extravillous trophoblast. Finally, RXRα and LXR showed coexpression in the same extravillous trophoblast cells. To conclude, our data show that LXR expression is decreased in miscarriage.

  10. Measurement of total risk of spontaneous abortion: the virtue of conditional risk estimation

    Modvig, J; Schmidt, L; Damsgaard, M T

    1990-01-01

    abortion risk include biochemical assays as well as life table technique, although the latter appears in two different forms. The consequences of using either of these are discussed. It is concluded that no study design so far is appropriate for measuring the total risk of spontaneous abortion from early...... conception to the end of the 27th week. It is proposed that pregnancy may be considered to consist of two or three specific periods and that different study designs should concentrate on measuring the conditional risk within each period. A careful estimate using this principle leads to an estimate of total...

  11. Factors contributes to spontaneous abortion caused by Listeria monocytogenes, in Tehran, Iran, 2015.

    Pourkaveh, B; Ahmadi, M; Eslami, G; Gachkar, L

    2016-01-01

    Spontaneous abortion is the loss of a fetus before the 20th week of pregnancy, when occurring naturally without any surgical or pharmaceutical intervention. On the other hand, Listeria monocytogenes, as one of the foodborne pathogens, is a causative agent of listeriosis. The transfer of L. monocytogenes in pregnant women occurs as self-limited flu-like symptoms which may result in abortion, stillbirth or premature birth of infected infants. The purpose of this study was the identification of Listeria monocytogenes risk factors in women with spontaneous abortion admitted to Tehran Province health care centers in 2015. In this cross-sectional study, 317 women were examined for L. monocytogenes using Polymerase Chain Reaction (PCR) and the related risk factors. Two questionnaires on "L. monocytogenes Probable Risk Factors" and "Socio Economic Factors" were completed. Out of 317 samples of vaginal swabs, 54 (17%) isolates of L. monocytogenes were identified. In addition significant differences in terms of age of mother and her husband, mother and the husband's level of education , house prices, place of residence, gestational age of first abortion, gestational age of current abortion, gestational age of second abortion, consumption of unpasteurized dairy products, consumption of feta and soft cheese, consumption of smoked see food products, consumption of processed meat products and half-cooked meat products, consumption of ready-to-eat vegetables, history of contact with domestic animals three month before pregnancy and during pregnancy and consumption of smoked meat products during pregnancy were studied between two groups of patients positive and negative with L. monocytogens (P < 0.001). Based on the study, the detection of L. monocytogens risk factor during pregnancy as well as taking the issue into account while giving information and counseling in pregnancy can be vital to reduce the incidence of this bacterium and subsequently its side effects during

  12. The role of Neospora caninum and Toxoplasma gondii in spontaneous bovine abortion in Argentina.

    Moore, D P; Regidor-Cerrillo, J; Morrell, E; Poso, M A; Cano, D B; Leunda, M R; Linschinky, L; Odeón, A C; Odriozola, E; Ortega-Mora, L M; Campero, C M

    2008-10-01

    The aim of the present work was to evaluate the role of Neospora caninum and Toxoplasma gondii infections in spontaneous bovine abortions in Argentina. Based on histopathological results, 70 presumptive cases of apicomplexan protozoal abortion from a total of 666 cases of spontaneous bovine abortion submitted to the National Institute of Agrarian Technology, Balcarce, from 1999 to 2007 were included in this study. N. caninum infection was diagnosed by an indirect fluorescent antibody test (IFAT), by immunohistochemistry (IHC) and by nested-PCR. T. gondii infection also was diagnosed by nested-PCR. DNA from fetuses was extracted primarily from CNS tissues. Heart, liver, muscle and/or placenta were processed when nervous tissue was not available. Sixty-six (9.9%) fetuses were positive by at least one technique (IFAT, IHC or nested-PCR) for N. caninum infection. Overall, there was poor agreement among results obtained by these diagnostic techniques. In contrast, no Toxoplasma-infection was detected in any aborted bovine fetus. PMID:18691819

  13. Change of T, B lymphocyte subsets and Th1/Th2 indexes of patients with recurrent spontaneous abortion

    Shi-Hua Zhou

    2016-01-01

    Objective:To analyze and investigate the change state of T, B lymphocyte subsets and Th1/Th2 indexes of patients with recurrent spontaneous abortion. Methods: A total of 92 patients with recurrent spontaneous abortion in our hospital from June 2013 to July 2015 were selected as the observation group and 92 women with health delivery history at the same time were selected as the control group,then the peripheral blood T, B lymphocyte subsets and Th1/Th2 indexes of two groups were detected and compared and the peripheral blood T, B lymphocyte subsets and Th1/Th2 indexes of patients with different gestational age at abortion and abortion times were compared too. Results:The peripheral blood T, B lymphocyte subsets and Th1/Th2 indexes of observation group and control group all had obvious differences,and those blood indexes levels' differences of patients with different gestational age at abortion and abortion times were obvious too, all P<0.05 and the differences were significant. Conclusions: The T, B lymphocyte subsets and Th1/Th2 indexes of patients with recurrent spontaneous abortion show abnormal state and the differences of detection results of patients with different gestational age at abortion and abortion times are relatively obvious,so those indexes should be monitored and improved intentinonally.

  14. Chromosomal Analysis of Couples with Repeated Spontaneous Abortions in Northeastern Iran

    Saeedeh Ghazaey; Fatemeh Keify; Farzaneh Mirzaei; Masumeh Maleki; Semiramis Tootian; Mitra Ahadian; Mohammad Reza Abbaszadegan

    2015-01-01

    Background: Cytogenetic study of reproductive wastage is an important aspect in determining the genetic background of early embryogenesis. Approximately 15 to 20% of all pregnancies in humans are terminated as recurrent spontaneous abortions (RSAs). The aim of this study was to detect chromosome abnormalities in couples with RSAs and to compare our results with those reported previously. Materials and Methods: In this retrospective study, the pattern of chromosomal aberrations ...

  15. The relationship between polymorphisms in the promoter region of Tim-3 and unexplained recurrent spontaneous abortion in Han Chinese women

    Shen, Yang; Wang, Chen; Hong, Dun; Zeng, Baojin; Fang, Congcheng; Yuan, Chiting; Fan, Lilong; Lv, Haiyan; Zhu, Min

    2013-01-01

    Background Recurrent spontaneous abortion (RSA) refers to 2 or more consecutive pregnancy losses, and RSA with unknown causes is called unexplained recurrent spontaneous abortion (URSA). Tim-3, a subtype of the T-cell immunoglobulin domain and mucin domain (Tim) protein family, might be an important regulatory molecule that plays a pivotal role in URSA, which might be triggered mostly by Th1/Th2 immune deviation. To understand the etiology and pathogenesis of URSA in Han Chinese women, we inv...

  16. Expression of the Inducible Nitric Oxide Synthase Isoform in Chorionic Villi in the Early Spontaneous Abortion

    2000-01-01

    To investigate the relationship between inducible nitric oxide synthase (iNOS) and the early spontaneous abortion. , in situ hybridization and immunohistochemistry were used to detect the expression of iNOS in trophoblasts in the early pregnancy with and without spontaneous abortion (group Ⅰ and group Ⅱ ). By light microscopy and computer color magic image analysis system (CMIAS), light density (D) and the positive cell number per statistic square (N/S) in situ hybridization were used to analyze the positive cell index, while total positive cells (N) and the positive unit (Pu) were used in immunohistochemistry. By in situ hybridization, D and N/S in trophoblasts were 0. 35±0. 028, 0. 07±0. 011 respectively in group Ⅰ and 0. 18±0. 016,0. 015±0. 003 in group Ⅱ . In terms of immunohistochemical staining, N and Pu were 0. 058±±0. 007, 11. 94±2. 01 in group Ⅰ and 0. 013±0. 009, 1. 08±0. 35 in group Ⅱ in trophoblasts. Significant differences existed between two groups. It is concluded that the higher nitric oxide produced by the higher expression of iNOS in trophoblasts might play an important role in the early spontaneous abortion.

  17. Spontaneous abortions among rubber workers and congenital malformations in their offspring.

    Lindbohm, M L; Hemminki, K; Kyyrönen, P; Kilpikari, I; Vainio, H

    1983-01-01

    Spontaneous abortions of hospitalized women and congenital malformations were analyzed among rubber workers to investigate the possibility of an association between reproductive problems and chemical exposures in the rubber industry. Information on workers was obtained from the membership register of the Union of Rubber and Leather Workers and from the personnel register of a rubber factory. The frequencies of spontaneous abortions did not appreciably differ when the pregnancies occurred during Union membership or during employment in the factory as compared with the pregnancies occurring before or after that time. A case-referent study concerning the association between different exposures and spontaneous abortions showed that the odds ratio for factory workers exposed to rubber chemicals was increased in the footwear department. A corresponding risk was not observed in the tire department. The contradictory observations may be explained by concomitant exposure to solvents in the footwear department or by other nonoccupational factors. The possible association between congenital malformations and exposures in the rubber and leather industries was studied by the case-referent technique. No significant increase in the risk of malformations was observed in any branch of employment. However, the numbers of malformations were rather small. PMID:6685340

  18. Complications and the effect of varicocelectomy on semen analysis, fertility, early ejaculation and spontaneous abortion

    Shamsa Ali

    2010-01-01

    Full Text Available Varicocele is still an enigma. Its effects on semen analysis, fertility and, more re-cently, early ejaculation and spontaneous abortion in spouses are not yet fully understood. In this retrospective study, we evaluated these four parameters (semen analysis, fertility, early ejacu-lation and spontaneous abortion among spouses in relation to varicocele and varicocelectomy during a 13-year period. A total of 1,711 patients with varicocele underwent varicocelectomy by high inguinal method (251 cases, subinguinal method (1,375 cases, scrotal method (34 cases, and subinguinal method with local anesthesia (38 cases. Our complication rate was acceptable. Sperm count, motility and morphology increased three months post operation in 55, 51, and 46%, respectively (P value 0.000, 0.000, and 0.015, respectively. Paternity was 56% after one year of post varicocelectomy follow-up. Only 7 out of 82 azoospermic men had sperm in their semen after varicocelectomy and only one of them with mild spermatogenic hypoplasia became a father. The spontaneous abortion rate in the spouses of respondents was 59%. Early ejaculation improved in 75% of the respondents. In conclusion, varicocelectomy does not improve sperm parameters in all men, but it improves pregnancy rate, early ejaculation, and scrotal pain.

  19. Spontaneous abortions after the Three Mile Island nuclear accident: a life table analysis

    A study was conducted to determine whether the incidence of spontaneous abortion was greater than expected near the Three Mile Island (TMI) nuclear power plant during the months following the March 28, 1979 accident. All persons living within five miles of TMI were registered shortly after the accident, and information on pregnancy at the time of the accident was collected. After one year, all pregnancy cases were followed up and outcomes ascertained. Using the life table method, it was found that, given pregnancies after four completed weeks of gestation counting from the first day of the last menstrual period, the estimated incidence of spontaneous abortion (miscarriage before completion of 16 weeks of gestation) was 15.1 per cent for women pregnant at the time of the TMI accident. Combining spontaneous abortions and stillbirths (delivery of a dead fetus after 16 weeks of gestation), the estimated incidence was 16.1 per cent for pregnancies after four completed weeks of gestation. Both incidences are comparable to baseline studies of fetal loss

  20. Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion?

    Tolstrup, J S; Kjær, S. K.; Munk, C;

    2003-01-01

    BACKGROUND: Consumption of caffeine and alcohol is suspected to affect pregnancy outcome. Use of both stimulants is widespread and even minor effects on fetal viability are of public health interest. METHODS: We performed a nested case-control study using prospective data from a population......-based cohort comprising 11088 women aged 20-29 years. From this cohort, women who experienced either a spontaneous abortion (n = 303) or who gave birth (n = 1381) during follow-up [mean time: 2.1 years (range: 1.6-3.4)] were selected. Associations between self-reported exposures to caffeine and/or alcohol at...... enrolment and spontaneous abortion were analysed by means of logistic regression. RESULTS: Compared with women with a pre-pregnancy intake of <75 mg caffeine per day, the adjusted odds ratio (95% confidence interval) for spontaneous abortion was 1.26 (0.77-2.06), 1.45 (0.87-2.41), 1.44 (0.87-2.37) and 1...

  1. Influence of hysteroscope examination for the comprehensive stress state of patients with recurrent spontaneous abortion

    Xiao-Hong Huang

    2015-01-01

    Objective:To observe and study the influence degree of hysteroscope examination for the comprehensive stress state of patients with recurrent spontaneous abortion.Methods:Seventy patients with recurrent spontaneous abortion who were intervened with hysteroscope examination in our hospital from January 2013 to April 2015 were selected as the study object, and they were divided into Group A (normal uterine cavity group, 35 cases) and Group B (intrauterine lesions group, 35 cases) according to the final examination results. Then the blood expression levels of stress hormones and pain stress indexes of two groups before the examination, at 5 min during the examination and at 5 min after the examination were detected, and the detection results of two groups at different times were compared.Results:The blood expression levels of stress hormones and pain stress indexes of Group B before the examination, at 5 min during the examination and at 5 min after the examination were all higher than those of Group A. And the blood expression levels of two groups at 5 min during the examination were all higher than those before the examination and at 5 min after the examination. The differences were all significant.Conclusions:The influence of hysteroscope examination for the comprehensive stress state of patients with recurrent spontaneous abortion is obvious, and it should be paid more attention to the control of stress degree of patients with intrauterine lesions during operation.

  2. Concomitant infection of Neospora caninum and Bovine Herpesvirus type 5 in spontaneous bovine abortions

    Maia S. Marin

    2013-11-01

    Full Text Available Bovine Herpesvirus type 5 (BoHV-5 has not been conclusively demonstrated to cause bovine abortion. Brain lesions produced by Neospora caninum and Bovine Herpesvirus type 1 (BoHV-1 exhibit common features. Therefore, careful microscopic evaluation and additional diagnostic procedures are required to achieve an accurate final etiological diagnosis. The aim of the present work was to investigate the occurrence of infections due to BoHV-1, BoHV-5 and N. caninum in 68 cases of spontaneous bovine abortions which showed microscopic lesions in the fetal central nervous system. This study allowed the identification of 4 (5.9% fetuses with dual infection by BoHV-5 and N. caninum and 33 (48.5% cases in which N. caninum was the sole pathogen identified. All cases were negative to BoHV-1. The results of this study provide evidence that dual infection by BoHV-5 and N. caninum occur during pregnancy in cattle; however, the role of BoHV-5 as a primary cause of bovine abortion needs further research. Molecular diagnosis of BoHV-5 and N. caninum confirmed the importance of applying complementary assays to improve the sensitivity of diagnosing bovine abortion.

  3. Abortion

    1985-01-01

    The Canadian Medical Association (CMA) recognizes that there is justification for abortion on medical and nonmedical socioeconomic grounds and that such an elective surgical procedure should be decided upon by the patient and the physician(s) concerned. Ideally, the service should be available to all women on an equitable basis across Canada. CMA has recommended the removal of all references to hospital therapeutic abortion committees as outlined in the Criminal Code of Canada. The Criminal C...

  4. Tumor Necrosis Factor-α Gene Polymorphisms in Korean Patients With Recurrent Spontaneous Abortion

    Lee, Bo Eun; Jeon, Young Joo; SHIN, JI EUN; Kim, Ji Hyang; Choi, Dong Hee; Jung, Yong Wook; Shim, Sung Han; Lee, Woo Sik; Kim, Nam Keun

    2013-01-01

    The objective of this study was to investigate the contribution of the tumor necrosis factor-α (TNF-α) gene polymorphisms to recurrent spontaneous abortion (RSA). The study participants consisted of 357 Korean women with RSA and 236 fertile women controls. Four TNF-α gene variants of all participants were analyzed by polymerase chain reaction–restriction fragment length polymorphism assay. The TNF-α -1031T>C and TNF-α -238G>A variants increased the risk of RSA TNF-α -1031TC+CC; adjusted odds ...

  5. Study on the homocysteine metabolism of patients with unexplained repeated spontaneous abortion

    2003-01-01

    Objective:To study the metabolism abnormality of homocysteine(Hcy) in unexplained repeated spontaneous abortion(URSA).Methods:The level of Hcy in sera was measured with hyperpressure liquid chromatography(HPLC);Folic acid and vitamin B12 were detected by radioimmune assay;anticardiolipin antibody (ACA) was detected by ELISA.Results:(1)The level of serum Hcy in URSA group was significantly higher than that in control group,showing a statistical significant difference(P<0.01).The level of Hcy was correlated with ages,but not correlated with areas,numbers of miscarriage,gestation age,primary or secondary abortions.(2)The levels of folic acid and vitamin B12 in URSA group were significantly lower than those in control group.The levels of serum folic acid and vitamin B12 were not correlated with age,area,numbers of miscarriage and abortion periods.(3)ACA positive rate in URSA was significantly higher than that in control group.The level of Hcy in ACA(+) group was significantly higher than that in ACA(-) group among URSA patients.Conclusions:Hyperhomocysteinemia,low folic acid state,and ACA were all the independent risk factors for URSA.Lacking of folic acid and vitamin B12 is one of the important causes of hyperhomocysteinemia.ACA and hyperhomocysteinemia may have synergistic action in the occurrence of URSA.

  6. [Herpetic infection of spermatozoa in failure of reproductive technologies and spontaneous abortion].

    Bocharova, E N; Bragina, E E; Gusak, Iu K; Zotov, V V; Tereshchenko, A B; Shileĭko, L V; Kurilo, L F; Klimova, R R; Kushch, A A

    2007-01-01

    Herpes simplex virus (HSV) was studied in ejaculate of 36 men whose wives had the history of spontaneous abortions, or failure of artificial insemination (AI), or extracorporeal fertilization (ECF). The control group consisted of 222 patients examined prophylactically after urogenital inflammation or for primary infertility. HSV was detected with immunofluorescence (IF) reaction with monoclonal antibodies to HSV antigens, rapid culture method (RCM) and transmission electronic microscopy. HSV antigens were detected in fraction of mobile spermatozoa in 13 (65%) of 20 samples from patients of the study group. HSV detectability in the study group was significantly higher than in the controls (p = 0.003). Intragametic capsides of HSV were detected at ultrastructural investigation in 13 of 19 (68%) ejaculate samples from patients of the study group in whom IF and/ or RCM results were positive. The study of 6 ejaculate samples of this group in which HSV was not detected by IF or RCM and 24 control samples HSV capsides were not detected. The following conclusions can be made: mobile spermatozoa of normal morphology can be infected with HSV; as shown morphologically, samples of ejaculate from men whose wives had spontaneous abortions contained intragametic HSV capsides; intragametic HSV infection of spermatozoa had a negative effect on the course of pregnancy and/or embryon vitality. PMID:17722621

  7. Methylenetetrahydrofolate reductase and transcobalamin genetic polymorphisms in human spontaneous abortion: biological and clinical implications

    Zetterberg Henrik

    2004-02-01

    Full Text Available Abstract The pathogenesis of human spontaneous abortion involves a complex interaction of several genetic and environmental factors. The firm association between increased homocysteine concentration and neural tube defects (NTD has led to the hypothesis that high concentrations of homocysteine might be embryotoxic and lead to decreased fetal viability. There are several genetic polymorphisms that are associated with defects in folate- and vitamin B12-dependent homocysteine metabolism. The methylenetetrahydrofolate reductase (MTHFR 677C>T and 1298A>C polymorphisms cause elevated homocysteine concentration and are associated with an increased risk of NTD. Additionally, low concentration of vitamin B12 (cobalamin or transcobalamin that delivers vitamin B12 to the cells of the body leads to hyperhomocysteinemia and is associated with NTD. This effect involves the transcobalamin (TC 776C>G polymorphism. Importantly, the biochemical consequences of these polymorphisms can be modified by folate and vitamin B12 supplementation. In this review, I focus on recent studies on the role of hyperhomocysteinemia-associated polymorphisms in the pathogenesis of human spontaneous abortion and discuss the possibility that periconceptional supplementation with folate and vitamin B12 might lower the incidence of miscarriage in women planning a pregnancy.

  8. Underreporting of induced and spontaneous abortion in the United States: an analysis of the 2002 National Survey of Family Growth.

    Jones, Rachel K; Kost, Kathryn

    2007-09-01

    Underreporting of induced abortions in surveys is widespread, both in countries where the procedure is illegal or highly restricted and in those where it is legal. In this study, we find that fewer than one half of induced abortions performed in the United States in 1997-2001 (47 percent) were reported by women during face-to-face interviews in the 2002 National Survey of Family Growth (NSFG). Hispanic and black women and those with low income were among the least likely to report their experience of abortion. Women were also less likely to report abortions that occurred when they were in their 20s. Second-trimester abortions were more likely to be reported than first-trimester terminations. The levels of recent spontaneous abortion reported in the 2002 NSFG were consistent with the accumulated body of clinical research, although substantially more lifetime pregnancy losses were reported on self-administered surveys than in face-to-face interviews. Subsequent research should explore strategies to improve information collected on abortion, and, in the interim, research involving pregnancy outcomes should be adjusted for unreported induced abortions. PMID:17933292

  9. Abortion.

    Savage, A

    1979-09-15

    I refer for termination anyone who requests it for--pace Mr V Tunkel, (28 July, p 253)--the law is generally regarded as being one of "abortion on demand." I have some misgivings as I do not believe that women in early pregnancy are always in a fit state to make a considered decision, and they cannot in the nature of things be given time. I have, however, become increasingly worried about the morbidity arising from the procedure, and it is interesting that letters on the subject (25 August, pp 495 and 496) should be followed by one reporting rupture of the uterus during prostaglandin-induced abortion--yet another complication to add to those of cervical incompetence, pelvic sepsis, and permanent neurological damage. In so far as these tragedies usually follow late terminations Mr John Corrie's Bill is to be welcomed. A few further points. I am not so cynical as to think that every impregnation is the result of a thoughtless act of male lust. Unlike Professor Peter Huntingford (25 August, p 496), I listen to men as well as women, and many of them are deeply involved emotionally in the pregnancy they have helped to produce. Certainly I think a man should have the right to be consulted if his wife is to undergo a procedure that might damage her health. It is unfair contemptuously to dismiss as "whims" opinions that differ from ones own. These may result from genuine conscientious doubts or inability to cope from overwork and understaffing. Abortion is quite the most expensive form of contraception, and perhaps in these days of financial stringency this should be taken into account. "Bigotry" is defined in my dictionary as "blind zeal." This could be said of those who enthusiastically promote a course of action without regard to circumstances, safety, or cost. PMID:497770

  10. Aberrant Expression of TNF-α and TGF-β1 mRNA in Spontaneous Abortion

    Ji-fen HU; Hong-chu BAO; Feng-chuan ZHU; Cai-ling YOU

    2004-01-01

    Objective To investigate the aberrant expressions of TNF-α and TGF-β1 in peripheral blood mononuclear cells (PBMCs) and placental tissues in patients with early spontaneous abortionMethods Using the technique of semi-quantitative reverse transcript-polymerase chain reaction (RT-PCR), TNF-α mRNA and TGF-β1 mRNA in PBMCs were measured in spontaneous abortion group (30 cases), normal pregnancy group (25 cases) and nonpregnant group (25 cases). The expressive intension of TNF-α protein and TGF-β1 protein in placental tissues was also identified by immunohistochemistry.Results Both levels of TNF-α mRNA and TGF-β1 mRNA expressed in PBMCs were significantly different between the three groups respectively (P<0. 05). Levels of TNF-α in syncytiotrophoblastic and cytotrophoblastic cells of the two aborted groups were substantially higher than those of the non-pregnant group (P<0. 01), but the levels of TGF-β1 in syncytiotrophoblastic cells of the two aborted groups were markedly lower than those of the non-pregnant group (P<0. 01).Conclusion There is potential relation between TGF-β1 at the fetomaternal interface and spontaneous abortion. TGF-β1 may contribute to the maintenance of pregnancy,and low-level expression of TGF-β1 may be associated with pregnancy failure.

  11. "A study on Stress, Depression and NK Cytotoxic Potential in Women with Recurrent Spontaneous Abortion "

    Alireza alib

    2006-03-01

    Full Text Available It has been recognized that acute and chronic stress has an impact on the immune system. Acute stress may have a stimulating effect on the immune system, while in the case of chronic stress specially depression, the immune system could be down-regulated. However, an association between depression and a higher number of circulating white blood cells with increased activity has been reported. Elevation in immune cell numbers and alteration in cytokine profiles are documented for women suffering sporadic spontaneous abortion with a high stress score. In spite of these contradictory results and to make a new approach in immunological (NK activity as well as psychological parameters (stress/depression in women suffering from recurrent spontaneous abortion (RSA the present study was planned. Forty-five women with a history of RSA and a matched control group were participated in this study. A questionnaire for life events known as life change units (LCU and the Beck Depression Inventory (BDI outlines were used and the socio-psychological events were recorded after visiting and interview. Fresh peripheral blood lymphocytes were taken as a source of NK activity and K562 cell line were used as NK sensitive target. The experiments were performed and the cells were analyzed with a flow-cytometer. The stress and the depression scores were determined 245±83.6 and 27.6±8.8 for women with RSA and 224±79.6 and 19.4±7.1 for non-RSA group respectively. There was an association between life stress scores and depression scores with r=0.65 and P=0.000 for RSA women. A correlation with r = -0.34 and P = 0.02 was found between depression scores and NK cytotoxicity. The Pearson correlation test showed a lack of relationship between high stress score and NK activity with the r=0.011 and P=0.95, but r= -0.30 and P=0.072 was obtained for high depression scores and NK cytotoxicity. Therefore, it could be suggested that in the case of women with a history of recurrent

  12. Autoantibody profile and other immunological parameters in recurrent spontaneous abortion patients

    U Shankarkumar

    2011-01-01

    Full Text Available Background: An autoimmune cause and related immunological alterations resulting in recurrent spontaneous abortion (RSA have been suggested in patients with unknown etiology. Materials and Methods: This study evaluated the autoantibody profile and other immunological parameters among RSA patients and normal pregnant women from Mumbai western India. Fifty RSA patients with unknown cause and greater than three consecutive abortions along with 50 normal pregnant women were studied for various auto antibodies such as ANA, anti-dsDNA, ANCA, AECA, 2 micro globulin, anti-HLA antibodies and ACLA using immunofluorescence microlymphocytotoxicity and ELISA. Immunological parameters such as HLA class I monoclonal antibody expression, CD3 (T cell, CD19 (B cell, and CD56 (NK cell were estimated by flow cytometry. Results: The results revealed 34% positivity of all auto antibodies tested among patients. ANA(12%, ANCA (20%, AECA (24%, ACLA (8%, anti-dsDNA(0%, β2 microglobulin (14%, and anti-HLA antibodies(10% among RSA patients were identified. An increased expression of HLA class I specific monoclonal antibody (10% with HLA A3 (16% specificity were found to correlate with shared HLA alleles among the RSA couples. Among normal pregnant (control group ANA (2%, ANCA (2%, AECA (3%, ACLA (4% and increased expression of CD56 with reduced HLA class I monoclonal were observed. Conclusion: Our findings suggest a possible role of various autoantibodies along with the related immunological parameters underlying RSA.

  13. Relationship between recurrent spontaneous abortion and anti-β2-glycoprotein I antibody

    Objective: To explore the relationship between recurrent spontaneous abortion (RSA) and anti-β2- glycoprotein I (anti-β2-GP I) antibody. Methods: The levels of anti-β2-GP I antibody in serum from 81 RSA patients and 39 normal women were detected by ELISA. Results: The positive rate of anti-β2-GP I in RSA patients (42.0%) was obviously higher than that in normal women (7.7 %) (P2-GP I IgG in statistics between RSA patients (40.8%) and normal women (7.7%) (P2-GP I IgM in statistics between RSA patients and normal women (P>0.05). There was no difference of the positive rate of anti-β2-GP I in statistics between early and late, as well as between 2 times and more than 2 times abortions of RSA (P>0.05). Conclusion: The anti-β2-GP I antibody is related to RSA, and it may be regarded as a immunological assistant diagnostic index for RSA. (authors)

  14. Chromosomal Analysis of Couples with Repeated Spontaneous Abortions in Northeastern Iran

    Saeedeh Ghazaey

    2015-04-01

    Full Text Available Background: Cytogenetic study of reproductive wastage is an important aspect in determining the genetic background of early embryogenesis. Approximately 15 to 20% of all pregnancies in humans are terminated as recurrent spontaneous abortions (RSAs. The aim of this study was to detect chromosome abnormalities in couples with RSAs and to compare our results with those reported previously. Materials and Methods: In this retrospective study, the pattern of chromosomal aberrations was evaluated during a six-year period from 2005 to 2011. The population under study was 728 couples who attended genetic counseling services for their RSAs at Pardis Clinical and Genetics Laboratory, Mashhad, Iran. Results: In this study, about 11.7% of couples were carriers of chromosomal aberrations. The majority of abnormalities were found in couples with history of abortion, without stillbirth or livebirth. Balanced reciprocal translocations, Robertsonian translocations, inversions and sex chromosome aneuploidy were seen in these cases. Balanced reciprocal translocations were the most frequent chromosomal anomalies (62.7% detected in current study. Conclusion: These findings suggest that chromosomal abnormalities can be one of the important causes of RSAs. In addition, cytogenetic study of families who experienced RSAs may prevent unnecessary treatment if RSA are caused by chromosomal abnormalities. The results of cytogenetic studies of RSA cases will provide a standard protocol for the genetic counselors in order to follow up and to help these families.

  15. Expression of prostaglandin receptors in Chlamydia trachomatis-infected recurrent spontaneous aborters.

    Singh, Namita; Prasad, Priya; Singh, Laishram Chandreshwar; Das, Banashree; Rastogi, Sangita

    2016-06-01

    A study was undertaken to quantify the expression of prostaglandin (PG) receptors and find the effect of gestational age on expression of PG receptor genes in Chlamydia trachomatis-infected recurrent spontaneous aborters (RSA). Endometrial curettage tissue (ECT) was collected from 130 RSA (Group I) and 100 age-matched controls (Group II) at the Department of Obstetrics and Gynecology, Safdarjung Hospital, New Delhi (India). PCR was performed for diagnosis of C. trachomatis cryptic plasmid; mRNA expression of PG receptor genes was assessed by real-time PCR (q-PCR), while serum progesterone/estrogen levels were determined by respective commercial kits. Data were evaluated statistically. A total of 15.4 % RSA (GroupI) were diagnosed as C. trachomatis-positive (200 bp), whereas controls were uninfected. q-PCR showed significant upregulation (PRSA, mean serum progesterone level was significantly low (PRSA. PMID:27028620

  16. Increased leukemia, lymphoma, and spontaneous abortion in Western New York following a flood disaster

    The New York State Department of Health was asked in September 1978 of investigate a cluster of leukemias and lymphomas in a rural town in western New York State of less than 1,000 people. Four cases of these diseases had been diagnosed in the town's population in the previous 10 months. Residents were concerned about environmental hazards such as background radiation and contamination of their water supply. A total environmental study of the area was not feasible or warranted, but certain environmental studies of the area were conducted. No environmental health hazards were identified. Incidence rates for towns in the four-county area (population 281,000) surrounding the study town were analyzed, based on data from the New York State Cancer Registry. These four counties had been severely affected by the flood following the 1972 Hurricane Agnes. Examination of annual leukemia and lymphoma incidence rates for these counties for 1966--77 revealed that the rates for towns in the river valley (population 102,000), but not for nonriver-valley towns, were 20 to 50 percent above the statewide rates for 1972--77. All other cancer rates remained level throughout both periods. An analysis of spontaneous abortion rates for the four counties for 1968--77 showed a significant peak in 1973, but not for the rest of upstate New York. The peak was concentrated in the towns in the river valley. The apparent time-space cluster of leukemias and lymphomas in conjunction with a marked increase in the spontaneous abortion rate suggests an unidentified flood-related environmental exposure

  17. [Grief, depression and anxiety after spontaneous abortion--a study of systematic evaluation and factors of influence].

    Beutel, M; Deckardt, R; Schaudig, K; Franke, S; Zauner, R

    1992-05-01

    Recent studies demonstrate profound and long-lasting adverse psychological and family sequelae of a spontaneous abortion. However, decisive issues of quality, course and determinants cannot be answered sufficiently due to shortcomings of research (e.g. lack of representative samples and adequate measures, reliance on cross-sectional study designs). Grief reactions and their determinants are differentiated in relation to depressiveness and anxiety in 86 patients from a longitudinal study, employing the Perinatal Grief Scale (Thoedter et al. 1988) and standardized symptom checklists. For the majority of the women, around the 10th week of gestation, the embryo is psychologically represented in fantasies, dreams and concrete arrangements in reality. Immediately after the abortion, these women react with painful feelings of "active grief" and "despair". Additional stresses in the pregnancy and lack of social support predict "self-reproachful coping". Women with recurrent abortions who have no children show depressive reactions. Retrospectively, these also present more anxiety and depressive moods during pregnancy. Results support reliability and validity of the grief scale. Implications for counselling and psychotherapy of women after a spontaneous abortion are discussed with respect to these risk constellations. PMID:1488507

  18. An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population.

    Arbuckle, T E; Lin, Z; Mery, L S

    2001-01-01

    The toxicity of pesticides on human reproduction is largely unknown--particularly how mixtures of pesticide products might affect fetal toxicity. The Ontario Farm Family Health Study collected data by questionnaire on the identity and timing of pesticide use on the farm, lifestyle factors, and a complete reproductive history from the farm operator and eligible couples living on the farm. A total of 2,110 women provided information on 3,936 pregnancies, including 395 spontaneous abortions. To ...

  19. Previous experience of spontaneous or elective abortion and risk for posttraumatic stress and depression during subsequent pregnancy

    Hamama, Lydia; Rauch, Sheila A. M.; SPERLICH, MICKEY; Defever, Erin; Seng, Julia S.

    2010-01-01

    This paper examines the impact of elective and spontaneous abortion (EAB/SAB) on mental health during subsequent pregnancy in a sample of women involved in a larger prospective study of posttraumatic stress disorder (PTSD) across the childbearing year (n = 1,581). Women expecting their first baby completed standardized telephone assessments including demographics, trauma history, PTSD, depression, pregnancy wantedness, and religiosity. Fourteen percent (n=221) experienced a prior elective abo...

  20. Risk of chromosomal abnormalities in early spontaneous abortion after assisted reproductive technology: a meta-analysis.

    Jun-Zhen Qin

    Full Text Available BACKGROUND: Studies on the risk of chromosomal abnormalities in early spontaneous abortion after assisted reproductive technology (ART are relatively controversial and insufficient. Thus, to obtain a more precise evaluation of the risk of embryonic chromosomal abnormalities in first-trimester miscarriage after ART, we performed a meta-analysis of all available case-control studies relating to the cytogenetic analysis of chromosomal abnormalities in first-trimester miscarriage after ART. METHODS: Literature search in the electronic databases MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL based on the established strategy. Meta-regression, subgroup analysis, and Galbraith plots were conducted to explore the sources of heterogeneity. RESULTS: A total of 15 studies with 1,896 cases and 1,186 controls relevant to the risk of chromosomal abnormalities in first- trimester miscarriage after ART, and 8 studies with 601 cases and 602 controls evaluating frequency of chromosome anomaly for maternal age≥35 versus <35 were eligible for the meta-analysis. No statistical difference was found in risk of chromosomally abnormal miscarriage compared to natural conception and the different types of ART utilized, whereas the risk of fetal aneuploidy significantly increased with maternal age≥35 (OR 2.88, 95% CI: 1.74-4.77. CONCLUSIONS: ART treatment does not present an increased risk for chromosomal abnormalities occurring in a first trimester miscarriage, but incidence of fetal aneuploidy could increase significantly with advancing maternal age.

  1. Insertion/deletion polymorphism in intron 16 of ACE gene in idiopathic recurrent spontaneous abortion: case-control study, systematic review and meta-analysis.

    Pereza, Nina; Ostojić, Saša; Zdravčević, Matea; Volk, Marija; Kapović, Miljenko; Peterlin, Borut

    2016-02-01

    The insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin I-converting enzyme gene (ACE) has been extensively studied as a predisposing factor for idiopathic recurrent spontaneous abortion (IRSA). A case-control study including 149 women with ≥3 spontaneous abortions and 149 controls was performed to test the association of ACE I/D polymorphism with IRSA. A systematic review was conducted of previous case-control studies, with strict selection criteria for meta-analyses. We also aimed to evaluate the potential differences in summary estimates between studies defining IRSA as ≥2 and ≥3 spontaneous abortions. Genotyping was performed by PCR, and systematic review conducted using PubMed and Scopus. There was no association of the polymorphism with IRSA in Slovenian women. Sixteen case-control studies, showing substantial differences regarding IRSA definition and selection criteria for women were identified. Meta-analysis was performed and included four studies defining IRSA as ≥2 spontaneous abortions and the current study, which defined IRSA as ≥3 spontaneous abortions. Based on random effects model, meta-analysis conducted on 1192 patients and 736 controls showed no association with IRSA under dominant(DD+IDvsII) and recessive(DDvsID+II) genetic models. Well-designed studies are needed to evaluate the role of ACE I/D polymorphism in IRSA defined as ≥3 spontaneous abortions. PMID:26673102

  2. Fatores Associados ao Aborto Espontâneo Recorrente Recurrent Spontaneous Abortion-associated Factors

    Ricardo Barini

    2000-05-01

    . Conclusão: para uma investigação completa dos fatores associados ao aborto espontâneo recorrente faz-se necessária a inclusão do fator aloimune, sem a qual a maior parte dos casos não terá etiologia esclarecida.Purpose: to identify recurrent spontaneous abortion- associated factors. Subjects: one hundred seventy-five outpatients were investigated from March 1993 to March 1997 at the "Ambulatório de Aborto Recorrente CAISM/UNICAMP". All of them had had three or more consecutive spontaneous abortions and/or two abortions and were 35 years or more old. Methods: the investigation protocol included: couple's karyotype; hysterosalpingography, serial plasma progesterone levels and/or endometrial biopsy; toxoplasmosis, listeriosis, brucelosis, lues and cytomegalovirus serum tests; Chlamydia trachomatis and Mycoplasma hominis cultures of cervical discharge; TSH and thyroid hormone levels; fasting glucose; autoantibody panel, anti-HLA antibody search by microlymphocytotoxicity crossmatch and one-way mixed lymphocyte culture with inhibitor factor detection. Husband's evaluation included: physical evaluation, lues, Chagas' disease, B and C hepatitis and AIDS serum tests, microlymphocytotoxicity crossmatch and one-way mixed lymphocyte culture with inhibitor factor detection. Results: alloimmune etiology was the most frequently found factor (86.3% of studied patients, represented by negative crossmatch and one-way mixed lymphocyte culture with inhibitor factor below 50%. The second most frequently found factor was cervical incompetence (22.8%, followed by hormonal factor (21.2%, mainly represented by luteal insufficiency. Some patients were found to have more than one etiologic factor. Conclusion: the investigation of recurrent spontaneous abortion-associated factors must include alloimmune etiology. Most cases will remain unexplained without this investigation.

  3. Association of HLA-DQB1 coding region with unexplained recurrent spontaneous abortion

    汪希鹏; 林其德; 陆佩华; 马政文; 赵爱民

    2004-01-01

    Background DNA analysis has shown a lack of significant compatibility between couples affected by unexplained recurrent spontaneous abortion (URSA) compared with normal fertile couples,8although one study that made use of a PCR-sequence-specific oligonucleotide (SSO) method did observe evidence of significant compatibility in the HLA-DQA1 and DQB1 alleles between patients and aborted fetuses. 9 This study was designed to investigate whether URSA were associated with particular DQ alleles or promoter alleles.Methods Thirty-two patients with URSA and 54 women who had had at least one successful pregnancy were included in this study. HLA-DQ genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The HLA-DQB1 promoter was detected by the SSO and sequence-specific primer (SSP) methods. The DQA1, DQB1, and DQB1 promoter (QBP) gene frequencies in the patients were compared with the gene frequencies in normal controls. The data were analyzed statistically with the X2 and Fisher's exact tests.Results The results showed that the frequency of DQB1 * 0604/0605 was significantly higher and the frequency of DQB1 * 0501/0502 was significantly lower in the patient group as compared with the normal controls. In addition, the frequencies of the DQA1 * 01-DQB1 * 0604/0605 and QBP6.2-DQB1 * 0604/0605 haplotypes were overrepresented in the patients relative to the controls. Our results did not show any differences between URSA patients and the controls with regard to DQA1 and QBP allele frequencies.Conclusions Our data suggest that URSA is associated with the HLA-DQB1 coding region, and is not associated with its upstream regulatory region. The DQB1 * 0604/0605, DQA1 * 01-DQB1 * 0604/0605, and QBP6.2-DQB1 * 0604/0605 haplotypes may confer susceptibility to URSA, while the DQB1 *0501/0502 allele may protect women from URSA.

  4. Association between p53 polymorphism at codon 72 and recurrent spontaneous abortion.

    Zhang, Ying; Wu, Yuan-Yuan; Qiao, Fu-Yuan; Zeng, Wan-Jiang

    2016-06-01

    p53 gene plays an important role in apoptosis, which is necessary for successful invasion of trophoblast cells. The change from an arginine (Arg) to a proline (Pro) at codon 72 can influence the biological activity of p53, which predisposes to an increased risk of recurrent spontaneous abortion (RSA). In order to investigate the association between p53 polymorphism at codon 72 and RSA, we conducted this meta-analysis. Pubmed, Embase and Web of science were used to identify the eligible studies. Odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the strength of the association. Six studies containing 937 cases of RSA and 830 controls were included, and there was one study deviated from Hardy-Weinberg equilibrium (HWE). There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not. A significant association was observed in allelic model (Pro vs. Arg; OR=1.28, 95% CI: 1.04-1.57) after exclusion of the study that was deviated from HWE. No association was noted in recessive model (Pro/Pro+Pro/Arg vs. Arg/Arg; OR=1.05, 95% CI: 0.86-1.30) and co-dominant model (Pro/Arg vs. Arg/Arg; OR=0.96, 95% CI: 0.77-1.19). Subgroup analysis by ethnicity also indicated a significant association between p53 polymorphism at codon 72 and RSA in Caucasian group. No heterogeneity and publication bias were found. Our meta-analysis implied that p53 polymorphism at codon 72 carries high maternal risk of RSA. PMID:27376811

  5. Double and multiple chromosomal aneuploidies in spontaneous abortions: A single institutional experience

    Shivakumar Subramaniyam

    2014-01-01

    Full Text Available Objective: To characterize double and multiple aneuploidies in spontaneous abortions (SAB. Materials and Methods: Retrospective analysis of cytogenetics data obtained by culturing/harvesting products of the conception material at our center from 2006 to 2009 was performed. The abnormal cytogenetic results, maternal age, gestational age, and previous pregnancy history were recorded and compared. Results: Double and multiple aneuploidies are rare, however, a high percentage of double (4.6% and multiple (0.4% chromosomal aneuploidies were observed in our study of 1502 cases of SAB. Of 1502 cases of SAB evaluated, 70 cases (4.6% showed double aneuploidy, whereas 6 cases (0.4% had multiple aneuploidies. The chromosomes most frequently involved in double aneuploidy in the decreasing order were 21, 16, ± X, 22, 18, 13, and 15. The most frequent chromosome combinations observed were: Loss of X/21 (8.5%, 21/22 (4.4%, 16/21 (4.4%, and 7/16 (4.4%. The chromosome combinations in multiple aneuploidy included trisomy of chromosomes X/5/8, 8/20/22, 16/20/22, 14/21/22, and loss of X with 21/21 and 7/21. These abnormalities were significantly observed in women between the age group 40-44 years (59.2%. A high success rate (94% of obtaining metaphase cells was observed in this study mainly due to the use of direct and long-term cultures. Conclusions: We observed a high percentage of double (4.6% and multiple (0.4% aneuploidies, frequently involving the acrocentic chromosomes 13, 15, 21, and 22 and nonacrocentric chromosomes X, 16, and 18.

  6. Association between the plasma/whole blood lead ratio and history of spontaneous abortion: a nested cross-sectional study

    Smith Donald

    2007-09-01

    Full Text Available Abstract Background Blood lead has been associated with an elevated risk of miscarriage. The plasmatic fraction of lead represents the toxicologically active fraction of lead. Women with a tendency to have a higher plasma/whole blood Pb ratio could tend towards an elevated risk of miscarriage due to a higher plasma Pb for a given whole blood Pb and would consequently have a history of spontaneous abortion. Methods We studied 207 pregnant Mexico City residents during the 1st trimester of pregnancy, originally recruited for two cohorts between 1997 and 2004. Criteria for inclusion in this study were having had at least one previous pregnancy, and having valid plasma and blood Pb measurements. Pb was measured in whole blood and plasma by inductively coupled plasma mass spectrometry using ultra-clean techniques. History of miscarriage in previous pregnancies was obtained by interview. The incidence rate of spontaneous abortion was defined as the proportion of previous pregnancies that resulted in miscarriage. Data were analyzed by means of Poisson regression models featuring the incidence rate of spontaneous abortion as the outcome and continuous or categorized plasma/blood Pb ratios as predictor variables. All models were adjusted for age and schooling. Additionally, logistic regression models featuring inclusion in the study sample as the outcome were fitted to assess potential selection bias. Results The mean number of miscarriages was 0.42 (range 0 to 4; mean Pb concentrations were 62.4 and 0.14 μg/L in whole blood and plasma respectively. Mean plasma/blood Pb ratio was 0.22%. We estimated that a 0.1% increment in the plasma/blood Pb ratio lead was associated to a 12% greater incidence of spontaneous abortion (p = 0.02. Women in the upper tertile of the plasma/blood Pb ratio had twice the incidence rate of those in the lower tertile (p = 0.02. Conditional on recruitment cohort, inclusion in the study sample was unrelated to observable

  7. Association of kinase insert domain-containing receptor (KDR) gene polymorphism/ haplotypes with recurrent spontaneous abortion and genetic structure

    Shahsavari, Shiva; Noormohammadi, Zahra; Zare Karizi, Shohreh

    2015-01-01

    Background: Recurrent spontaneous abortion is one of the diseases that can lead to physical, psychological, and, economical problems for both individuals and society. Recently a few numbers of genetic polymorphisms in kinase insert domain-containing receptor (KDR) gene are examined that can endanger the life of the fetus in pregnant women. Objective: The risk of KDR gene polymorphisms was investigated in Iranian women with idiopathic recurrent spontaneous abortion (RSA). Materials and Methods: A case controlled study was performed. One hundred idiopathic recurrent spontaneous abortion patients with at least two consecutive pregnancy losses before 20 weeks of gestational age with normal karyotypes were included in the study. Also, 100 healthy women with at least one natural pregnancy were studied as control group. Two functional SNPs located in KDR gene; rs1870377 (Q472H), and rs2305948 (V297I) as well as one tag SNP in the intron region (rs6838752) were genotyped by using PCR based restriction fragment length polymorphism (PCR-RFLP) technique. Haplotype frequency was determined for these three SNPs’ genotypes. Analysis of genetic STRUCTURE and K means clustering were performed to study genetic variation. Results: Functional SNP (rs1870377) was highly linked to tag SNP (rs6838752) (D´ value=0. 214; χ2 = 16.44, p<0. 001). K means clustering showed that k = 8 as the best fit for the optimal number of genetic subgroups in our studied materials. This result was in agreement with Neighbor Joining cluster analysis. Conclusion: In our study, the allele and genotype frequencies were not associated with RSA between patient and control individuals. Inconsistent results in different populations with different allele frequencies among RSA patients and controls may be due to ethnic variation and used sample size. PMID:27141535

  8. Cell-Free Fetal DNA and Cell-Free Total DNA Levels in Spontaneous Abortion with Fetal Chromosomal Aneuploidy

    Ji Hyae Lim; Min Hyoung Kim; You Jung Han; Da Eun Lee; So Yeon Park; Jung Yeol Han; Moon Young Kim; Hyun Mee Ryu

    2013-01-01

    BACKGROUND: Cell-free fetal DNA and cell-free total DNA in maternal circulation have been proposed as potential markers for noninvasive monitoring of the placental condition during the pregnancy. However, the correlation of and change in cell-free fetal DNA and cell-free total DNA in spontaneous abortion (SA) with fetal chromosomal aneuploidy have not yet been reported. Therefore, we investigated cell-free fetal DNA and cell-free total DNA levels in SA women with fetal chromosomal aneuploidy....

  9. HLA allele associations in idiopathic recurrent spontaneous abortion patients from India

    U Shankarkumar

    2008-01-01

    Full Text Available Background : Rejection of semiallogenic foetus in recurrent spontaneous abortion (RSA has been postulated to be a consequence of genetic and immunological phenomena. Aim: To evaluate the role of human leukocyte antigen (HLA alleles in RSA in Indian couples. Settings and Design : A case-control study. Materials and Methods : Eighty-one randomly selected couples with unexplained three or more RSAs and a control group of 97 couples with live birth belonging to the same ethnic background, referred to the Gynaecology Department, KEM Hospital were included in the case-control study. Serological HLA A and B typing was done followed by molecular subtypes, defined using PCR-SSOP technique for HLA A, B, and C in 40 couples and DRB1FNx01 and DQB1FNx01 in 28 couples which were then compared with appropriate case 46 and 88 controls. Results : Serologically A3 (15.43% vs . 4.43%; odds ratio (OR = 4.34; P = 0.0002 and B17 (25.3% vs . 11.34%; OR = 3.49; P = 0.0001 were increased. Haplotype A1-B17 was significantly increased. Molecular subtyping revealed that AFNx01030102 (11.25% vs . 4.34%; OR = 3.00; P = 0.07, BFNx015701 (11.25% vs . 1.08%; OR = 13.10; P = 0.003, CwFNx01120201 (25% vs . 4.34%; OR = 10.50; P = 2.05E-05, HLA DRB1FNx01030101 (17.85% vs . 3.40%; OR = 7.6; P = 0.0001, DRB1FNx01150101 (32.14% vs . 13.63%; OR = 4.8; P = 0.0003, and DQB1FNx01060101 (35.71% vs . 29.34%; OR = 2.3; P = 0.004 were significantly increased in patients. A differential association was noticed when compared with reported world RSA patients. Conclusion: The HLA alleles AFNx01030101, BFNx015701, CwFNx01120201, DRB1FNx01030101, and DRB1FNx01150101 as well as their associated ancestral haplotype may play a significant role in development of RSA in India.

  10. Abortion - medical

    ... womb (uterus). There are different types of medical abortions: Therapeutic medical abortion is done because the woman has ... Therapeutic medical abortion; Elective medical abortion; Induced abortion; Nonsurgical abortion

  11. Association between Spontaneous abortion and Presence of anti thyroid antibodies in mother’s serum

    Mahmoud Mirhosseini

    2012-12-01

    Results: Out of 51 subjects, 18 had positive Anti-TPO-Ab, of which -10 were among the cases and 8 belonged to the controls. Out of 18 women with positive AntiTG-Ab, 11 cases were in the control group and 7 were in the cases. The differences between the control group and the amounts of Anti-TPO-Abs (P=0.468 and Anti-TG-Abs (P=0.675 were not swignificant. Conclusion: The results revealed that there is no association between abortion and presence of antithyroid antibodies in mother’s serum. Other abortion causes such as various kinds of infections and smoking might be involved which requires more research.

  12. T-HELPER 1 CYTOKINES INCREASE DURING EARLY PREGNANCY IN WOMEN WITH A HISTORY OF RECURRENT SPONTANEOUS ABORTION

    A. Rezaei A. Dabbagh

    2000-08-01

    Full Text Available The measurment of various cytokines may provide a different tool for evaluation of the immune system. Recent investigations have shown that the number and function of peripheral natural killer cells (NK- cells increase during early pregnancy in women with a history of unexplained recurrent spontaneous abortions (RSA. NK-cells activity may be responsible for some cases of RSA. The objective of this study was to assess the role of the Thl cytokines (IL-2, IFN-y, TNF-a ; TNF-/0 in this phenomenon, and detection of Thl cytokines in women with RSA. The control group consisted of 40 women with no history of pregnancy loss and complication. The abortion group comprised of 92 women having at least 3 pregnancy losses. Blood from the control group and women with RSA was taken at the end of first trimester of gestational age and at the time of abortion, respectively. Sera were separated and peripheral blood lymphocytes were challenged with PHA using RPMI medium. All samples were tested for concentration of Thl cytokines using ELISA methods. It was considered that sera from women with RSA produced higher concentration of TNF-«, TNF-/? , and IL-2 in comparison with sera from normal pregnant women (NPW (P<0.001. We were not able to detect IL-2 in (NPW whereas in 31% sera from RSA group, IL-2 was detectable (P<0.001. However, there was no significant difference between IFN-y, concentration in sera from patients and control group (P<0.182. Tissue culture supernatant from women with RSA also produced higher concentration of TNF-a. IFN-y, TNF-/* and IL2, than control group. These data may explain the increase NK-cells cytotoxicity during early pregnancy in women with a history of RSA. It may also provide a diagnostic tool to predict the outcome of pregnancy.

  13. Relationship between the Abnormal Expression of FasL on Human First Trimester Trophoblast and Spontaneous Abortion

    邱红玉; 孙永玉

    2003-01-01

    In order to study the molecular immune-pathological mechanism of spontaneous abortion (SA), immunohistochemistry techniques were used to detect the FasL expression of first trimester trophoblast in the SA patients and normal controls. High precise color-image measure system for immuno-histochemistry (HPIS) was used to determine the quantity of FasL expression. The results showed that the scale and intensity of FasL expression on the trophoblasts in SA group were significantly lower than in the control group. It is indicated that abnormal expression of FasL on trophoblasts, which damages the immunological tolerance between mother and fetus, may be one of the important mechanisms of development of SA. To induce the expression of FasL or to regulate the immunological tolerance will be a new way to treat SA.

  14. Decreased mean platelet volume is associated with the developing stage of fetoplacental unit in spontaneous abortion

    Kaplanoglu, Mustafa; Yuce, Tuncay; Bulbul, Mehmet

    2015-01-01

    Aim: The aim was to evaluate the place of mean platelet volume (MPV) in predicting spontaneous miscarriage and to identify any differences in its values following miscarriage after biochemical and clinical pregnancy. Material and method: We retrospectively evaluated the data of 305 spontaneous miscarriages and 168 control subjects. The miscarriage subjects were evaluated in two groups: miscarriage after biochemical pregnancy (n=79) (BA group) and miscarriage after clinical pregnancy (n=226) (...

  15. 内分泌异常与复发性流产%Endocrine Abnormalities and Recurrent Spontaneous Abortion

    李倩; 梁晓燕

    2013-01-01

    The recurrent miscarriage is traditionally defined as three or more consecutive pregnancy losses before 20 weeks. The causes of recurrent spontaneous abortion are not clear,including genetic factors, uterine abnormalities,immunologic and endocrine factors,infections,and unexplained abortion. The endocrine disorders is related to recurrent miscarriage, including disorders of both reproductive glands and other glands. This article discussed the relationships between recurrent spontaneous abortion and endocrine disorders such as luteal insufficiency,thyroid dysfunction,hyperprolactinemia,insulin resistance and hyperandrogenism. However, it needs more study to understand the mechanism of recurrent miscarriage caused by endocrine abnormalities.%复发性流产是指在妊娠20周前,连续发生2次或以上自然流产。复发性流产的病因目前尚未明确,主要包括遗传因素、解剖异常、内分泌异常、感染、免疫因素及不明原因的复发性流产。其中内分泌异常与复发性流产密切相关,无论是生殖腺分泌功能异常或其他相关内分泌腺体分泌异常,都有可能导致复发性流产的发生。从黄体功能不足、甲状腺功能异常、高催乳素血症、胰岛素抵抗及高雄激素血症等方面,探讨内分泌异常与复发性流产之间的相关性。内分泌异常会导致复发性流产,但是其具体机制仍需要进一步探索。

  16. T-helper 1-type immunity to trophoblast in patients with recurrent spontaneous abortion

    2001-01-01

    Objective:To test the hypothesis that peripheral blood mononuclear cells (PBMCs) in women with unexplained recurrent abortion (URA) produce T-helper 1 (Th1)-type cytokines in response to trophoblastantigens. Methods: A total of 25 women with URA and 15 reproductively normal parous control women participated the study. Supernatants from trophoblast-activatied PBMCs from all participants were tested by enzyme-linked immunosorbent assay(ELISA) for Th1-type cytokines [interleukin-2 (IL-2), interferon gamma(IFN-γ)] and Th2-type cytokines (IL-4,IL-10). Results: The levels of IL-2, IFN-γ in trophoblast-activitated PBMCs supernatants from URA patients were highr than those from reproductively normal women (P<0.05). In contrast, the supernatants from URA patients contained lower Th2-type cytokines (IL-4,IL- 10) (P<0.05). Conclusions: Whereas Th1-type immunity to trophoblast is assoicated withURA and may play a role in reproductive failure, Th2-type immunity may a natural response to trophoblast contributing to successful pregnancy.

  17. Study of miR-155 expression in villus tissue of patients with recurrent spontaneous abortion and its relationship with apoptosis molecules and angiogenesis molecules

    Hong-Ying Du; Man-Zhen Zuo; Qiao-Ling Wang; Xiao-Juan Xie

    2016-01-01

    Objective:To study miR-155 expression in villus tissue of patients with recurrent spontaneous abortion and its relationship with apoptosis molecules and angiogenesis molecules.Methods:40 cases of patients with unexplained recurrent spontaneous abortion were selected as URSA group, 30 cases of normal early pregnant women receiving artificial abortion were selected as control group, and villus tissue was collected to detect expression levels of miR-155, apoptosis molecules (Bcl-2, Bcl-xl, Bax, Bad, Fas and FasL) and angiogenesis molecules (HIF-1α, VEGF and sFlt-1).Results: MiR-155 expression level in villus tissue of URSA group was significantly lower than that of control group and the more the times of abortion, the lower the miR-155 expression level; pro-apoptosis molecules Bax, Bad, Fas and FasL expression levels in villus tissue of URSA group were higher than those of control group and negatively correlated with miR-155 expression level, and anti-apoptosis genes Bcl-2 and Bcl-xl expression levels were lower than those of control group and positively correlated with miR-155 expression level; HIF-1α and VEGF expression levels in villus tissue of URSA group were lower than those of control group and positively correlated with miR-155 expression level, and sFlt-1 expression level was higher than that of control group and negatively correlated with miR-155 expression level.Conclusions:MiR-155 is lowly expressed in villus tissue of patients with recurrent spontaneous abortion, and miR-155 may be involved in the occurrence and development of the disease through regulating the expression of apoptosis molecules and angiogenesis molecules.

  18. Abortion; 1 : 2 000 000

    The cartogram represents the crude rate of abortions (number of abortions per 1,000 inhabitants) in the individual districts, crude abortion rate in Slovakia: 0.54 %, number of all abortions (average of 1996 - 1998) is presented. The complicated mosaics reveals two main spatial cores of the highest abortion rate. The first is in the south-west of Slovakia, from Malacky to Komarno, and the second, the largest, is from Ziar nad Hronom and Velky Krtis as far as Michalovce. In contrary, the rate of abortions is registered in the northern districts of the eastern Slovakia, almost the whole region Presov and in the northern districts of the region of Zilina. The size of the sign expresses the absolute number of abortions and simultaneously the structure of abortions: spontaneous and induced abortions. The higher share of the spontaneous abortions (more than a quarter) generally occurs in the districts with the lowest abortion rate. (authors)

  19. [Increased expressions of Blimp-1 and Bcl-6 in the deciduas of patients with unexplained recurrent spontaneous abortion].

    Gong, Qiaoqiao; Zhu, Yuejie; Pang, Pan; Huang, Yuhong; Zhao, Junda; Zhao, Jing; LA, Xiaolin; Ding, Jianbing

    2016-07-01

    Objective To oberseve the expressions of B cell lymphoma 6 (Bcl-6) and B lymphocyte-induced maturation protein 1 (Blimp-1) in the decidua of patients with unexplained recurrent spontaneous abortion (URSA), and investigate the roles that Bcl-6 and Blimp-1 act in URSA. Methods Decidual tissues were collected from patients with URSA (URSA group) and normal pregnant women (control group). Then, we detected the expressions of Bcl-6 and Blimp-1 in the deciduas of the two groups using real-time fluorescent quantitative PCR and immunohistochemistry. The relationship between Blimp-1 and Bcl-6 was estimated by Pearson's correlation analysis. Results Compared with the control group, the levels of Blimp-1 mRNA and protein, Bcl-6 mRNA significantly increased in the URSA group. However, Bcl-6 protein was raised insignificantly in URSA group. Furthermore, there was a positive correlation between Bcl-6 and Blimp-1 at the level of mRNA. Conclusion The expressions of Bcl-6 and Blimp-1 are enhanced in the deciduas of URSA patients. PMID:27363279

  20. Early detection of Toxoplasma gondii by real-time polymerase chain reaction methods in patients with recurrent spontaneous abortions

    Parviz Saleh

    2014-11-01

    Full Text Available Introduction: One of the causes of recurrent spontaneous abortions (RSA is an infection by the toxoplasmosis Protozoa. In comparison, we present detailed results using real-time polymerase chain reaction (PCR methods of detection. In this study, it was tried to detect Toxoplasma gondii (T. gondii by real-time PCR methods in patients with RSA. Methods: Amniotic fluid sampling was performed in the 16-20th weeks of gestation in 50 pregnant women with a history of RSA. The extracted deoxyribonucleic acid (DNA samples were analyzed using quantitative real-time PCR. Results: In all the cases, the detection of T. gondii was negative in the peripheral blood, and amniotic fluid samples by using the molecular methods (real-time PCR. Using the serological detection methods, 6% of patients were diagnosed as positive for the immunoglobulin M (IgM antibody. In addition, the IgG antibody was positive in 46% of the patients. Conclusion: It can be concluded that the serological methods lack specificity.

  1. Abortion, Miscarriage, and Breast Cancer Risk

    ... of Breast & Gynecologic Cancers Breast Cancer Screening Research Abortion, Miscarriage, and Breast Cancer Risk A woman’s hormone ... be conducted to determine whether having an induced abortion, or a miscarriage (also known as spontaneous abortion), ...

  2. Prevalence and diversity of Arcobacter spp. isolated from the internal organs of spontaneous porcine abortions in Denmark

    On, Stephen L.W.; Jensen, Tim Kåre; Bille-Hansen, Vivi; Jorsal, Sven Erik Lind; Vandamme, P.

    2002-01-01

    aborted fetuses from a single sow. The high prevalence of arcobacters in Danish pig abortions may account for at least some of the >90% of cases in which no established abortifacient agent is detected, but further studies are needed to define the role of each species, especially where co-infections with......A study was conducted to determine the prevalence and possible significance of campylobacteria in pig abortions in Denmark, Surface-cauterised liver and kidney samples from 55 aborted pig fetuses submitted to the Danish Veterinary Laboratory were taken and a sensitive isolation procedure used to...

  3. Abortion - surgical

    Suction curettage; Surgical abortion; Elective abortion - surgical; Therapeutic abortion - surgical ... problem. Your pregnancy is harmful to your health (therapeutic abortion). The pregnancy resulted after a traumatic event such ...

  4. Matrix metalloproteinases 1, 2, 3 and 9 functional single-nucleotide polymorphisms in idiopathic recurrent spontaneous abortion.

    Pereza, Nina; Ostojić, Saša; Volk, Marija; Kapović, Miljenko; Peterlin, Borut

    2012-05-01

    Idiopathic recurrent spontaneous abortion (IRSA) has been associated with abnormalities in the remodelling of endometrial extracellular matrix, as well as aberrant matrix metalloproteinase (MMP) gene expression in endometrium of IRSA women and chorionic villi of IRSA concept. This study investigated the association of five functional MMP gene promoter polymorphisms (MMP1 -1607 1G/2G, MMP2 -735 C/T, MMP2 -1306 C/T, MMP3 -1612 5A/6A and MMP9 -1562 C/T) with IRSA. A total of 149 couples with at least three consecutive IRSA and 149 fertile couples were included in a case-control study. Genotype analysis was performed using PCR restriction fragment length polymorphism. Statistically significant differences were found in distributions of MMP2 -735 CT (chi-squared 10.21, P=0.006; OR 2.15, 95% CI 1.34-3.45, P=0.001), and MMP9 -1562 CC (chi-squared 9.06, P=0.010; OR 2.21, 95% CI 1.30-3.80, P=0.004) between IRSA women and controls. Combined analysis of MMP gene polymorphisms did not increase their predictive value. There were no statistically significant differences in genotype and allele frequencies of any polymorphism between IRSA men and controls. MMP2 -735 C/T and MMP9 -1562 C/T functional gene polymorphisms might be associated with an increased risk of IRSA in women. Considering the insufficient knowledge on genetic contribution to pregnancy loss, studies on genetic causes of idiopathic recurrent spontaneous abortion (IRSA) are of great importance. Development of a histologically and functionally normal endometrium is critical for subsequent endometrial decidualization, receptivity and implantation. The proper communication and interaction between maternal decidual cells and the embryo is essential for the establishment of a functional fetal-maternal interface. IRSA has been associated with abnormalities in the remodelling of endometrial extracellular matrix, as well as aberrant matrix metalloproteinase (MMP) gene expression in endometrium of IRSA women and chorionic

  5. The Role of CD16+, CD56+, NK (CD16+/CD56+ and B CD20+ Cells in the Outcome of Pregnancy in Women with Recurrent Spontaneous Abortion

    Mehri Ghafourian

    2015-01-01

    Full Text Available Objectives: Recurrent Spontaneous Abortion (RSA is the most common complication of pregnancy. It is considered as one of the most important issues of reproduction in the world. RSA is defined as having three or more miscarriages in the first trimester of pregnancy. Increase in peripheral blood lymphocytes may be associated with abortion; therefore,the study was aimed to investigate and compare the peripheral blood CD16+, CD56+, NK(CD16+/CD56+ and B CD20+ cells populations in diagnosis and on pregnancy outcome in women with abortion. Materials and Methods: In this case-control study, 25 non-pregnant women with at least 3 abortions without obvious reason and 25 non-pregnant women with a living child without history of previous abortion participated. Using monoclonal antibodies anti (CD16, CD56 and CD20 and flow cytometry method, the percentage of cells with these markers was determined. Data analysis was performed by with SPSS 15 software and T-test. Results: CD16+, CD56+ and NK (CD16+/CD56+ cells significantly increased in women with RSA compared with control group (P≤0.05 but there were no significant differences in the percentage of B CD20+ cells between the experimental and control groups (P>0.05. Conclusion: According to the results of the present study, increased percentage of NK cells may be considered as a risk factor for RSA but involvement and the role of B CD20+ lymphocytes in RSA cannot be confirmed; however, in regard to important role of B and NK cell in the management of the immune responses, more studies are required to understand the behavior of these cells in the different stages of pregnancy more efficiently

  6. 人微小病毒B19感染与自然流产的关系%Relationship between human parvovirus B19 and spontaneous abortion

    刘元元; 简子娟; 高骞; 彭婉婵; 谷秀梅; 刘文恩

    2011-01-01

    目的 通过分析自然流产与正常妊娠晚期待产孕妇人微小病毒B19(HPV B19)DNA及IgM抗体检测情况,探讨HPV B19与自然流产的关系.方法 采集自然流产孕妇(观察组,28例)与正常待产孕妇(对照组,33例)的静脉血,以聚合酶链反应(PCR)法检测HPV B19 DNA,酶联免疫吸附试验(ELISA)检测HPV B19 IgM抗体.结果 观察组HPV B19 DNA阳性率为28.57%(8/28),对照组为9.09%(3/33),两组HPV B19 DNA阳性率比较,差异有统计学意义(x2=3.98,P<0.05).观察组检测出1例(3.57%,1/28)HPV B19 IgM抗体阳性,对照组未检测到阳性者(0.00%).结论 自然流产孕妇HPV B19感染率高于妊娠晚期待产孕妇,推测HPV B19感染可能是导致自然流产的原因之一.%Objective To investigate the relationship between human parvovirus B19 and spontaneous abortion by detecting human parvovirus B19 DNA and IgM of women in normal pregnancy and spontaneous abortion. Methods The blood of women in abortion (observation group, 28 cases) and normal pregnancy (control group, 33 cases)were collected, human parvovirus B19 DNA and IgM were detected with PCR and ELISA. Results The positive rate of human parvovirus B19 DNA was 28. 57% (8/28) in observation group and 9. 09% (3/33) in control group,there was significant difference between two groups(x2 = 3. 98, P<0. 05); human parvovirus B19 IgM was detected in one sample of observation group (3. 57%, 1/28), positive samples were not detected in the control group (0. 00%). Conclusion Human parvovirus B19 infection rate is higher in women of spontaneous abortion than in normal pregnant women, suggesting that human parvovirus B19 infection may be one of the causes leading to abortion.

  7. Induced Abortion

    ... Education & Events Advocacy For Patients About ACOG Induced Abortion Home For Patients Search FAQs Induced Abortion Page ... Induced Abortion FAQ043, May 2015 PDF Format Induced Abortion Special Procedures What is an induced abortion? What ...

  8. Abortion - medical

    Therapeutic medical abortion; Elective medical abortion; Induced abortion; Nonsurgical abortion ... A medical, or nonsurgical, abortion can be done within 7 weeks from the first day of the woman's last ...

  9. Cell-free fetal DNA and cell-free total DNA levels in spontaneous abortion with fetal chromosomal aneuploidy.

    Ji Hyae Lim

    Full Text Available BACKGROUND: Cell-free fetal DNA and cell-free total DNA in maternal circulation have been proposed as potential markers for noninvasive monitoring of the placental condition during the pregnancy. However, the correlation of and change in cell-free fetal DNA and cell-free total DNA in spontaneous abortion (SA with fetal chromosomal aneuploidy have not yet been reported. Therefore, we investigated cell-free fetal DNA and cell-free total DNA levels in SA women with fetal chromosomal aneuploidy. METHODOLOGY/PRINCIPAL FINDINGS: A nested case-control study was conducted with maternal plasma collected from 268 women in their first trimester of pregnancy. Subjects included 41 SA with normal fetal karyotype, 26 SA with fetal chromosomal aneuploidy, and 201 normal controls. The unmethylated PDE9A gene was used to measure the maternal plasma levels of cell-free fetal DNA. The GAPDH gene was used to measure the maternal plasma levels of cell-free total DNA. The diagnostic accuracy was measured using receiver-operating characteristic (ROC curves. Levels of cell-free fetal DNA and cell-free total DNA were significantly higher in both SA women with normal fetal karyotype and SA women with fetal chromosomal aneuploidy in comparison with the normal controls (P<0.001 in both. The correlation between cell-free fetal DNA and cell-free total DNA levels was stronger in the normal controls (r = 0.843, P<0.001 than in SA women with normal karyotype (r = 0.465, P = 0.002 and SA women with fetal chromosomal aneuploidy (r = 0.412, P = 0.037. The area under the ROC curve for cell-free fetal DNA and cell-free total DNA was 0.898 (95% CI, 0.852-0.945 and 0.939 (95% CI, 0.903-0.975, respectively. CONCLUSIONS: Significantly high levels of cell-free fetal DNA and cell-free total DNA were found in SA women with fetal chromosomal aneuploidy. Our findings suggest that cell-free fetal DNA and cell-free total DNA may be useful biomarkers for the prediction of SA

  10. Variations in T-helper 17 and Regulatory T Cells during The Menstrual Cycle in Peripheral Blood of Women with Recurrent Spontaneous Abortion

    Nasrin Sereshki

    2014-03-01

    Full Text Available Background: Disorders in immune system regulation may result in pregnancy abnormalities such as recurrent spontaneous abortion (RSA. This study aims to determine the ratio of regulatory T (Treg and T helper (Th 17 cells in unexplained RSA (URSA women during proliferative and secretory phases of their menstrual cycles compared to healthy non-pregnant women. Materials and Methods: In this case control study, 25 women with URSA and 35 healthy, non-pregnant women were enrolled. The percentage of Th17 and Treg cells in participants peripheral blood were determined by flow cytometry. Results: The percentage of Th17 cells and their related cytokines in serum (IL-17A were higher in the proliferative and secretory phases of the menstrual cycles of URSA women compared to the control women. However, a lower percentage of Treg cells and their related cytokines in serum, transforming growth factor (TGF β1 and interleukin (IL-10 were detected in the proliferative but not the secretory phase of the URSA group. The ratio of Th17/CD4+ Treg was higher in the URSA group than the control group. We observed an increased ratio of Th17/CD4+ Treg during the proliferative and secretory phases in URSA women. Conclusion: The imbalance between Th17 and Treg cells during the proliferative phase of menstrual cycles in the URSA group may be considered a cause for spontaneous abortion.

  11. Prevalence and diversity of Arcobacter spp. isolated from the internal organs of spontaneous porcine abortions in Denmark

    On, Stephen L.W.; Jensen, Tim Kåre; Bille-Hansen, Vivi;

    2002-01-01

    pathogens (Brucella, Leptospira, PPV PRRSV), but Arcobacter spp, were recovered from 23/55 abortions. Co-infections with Streptococcus suis, Escherichia coli, and haemolytic streptococci were observed in 7/23 Arcobacter-positive fetuses, and in 4/32 Arcobacter-negative fetuses, Histopathological analyses...

  12. Abortion - surgical

    Suction curettage; Surgical abortion; Elective abortion - surgical; Therapeutic abortion - surgical ... Surgical abortion involves dilating the opening to the uterus (cervix) and placing a small suction tube into the uterus. ...

  13. Analysis on the causes of spontaneous abortion of pregnant women in Yimeng mountain area%沂蒙山区孕妇自然流产原因分析

    杨淑兰; 姜开福; 高辉花; 王开英; 公晓琳; 赵军; 崔海霞

    2011-01-01

    Objective: To explore the incidence and main causes of spontaneous abortion in Yimeng mountain ares.Methods:Random cluster sampling method was used in the study, the related data of the cases with spontaneous women and their husbands in Yimeng mountain area from January 1, 2006 to June 30, 2008 were analyzed by retrospective epidemiological survey.Results: The incidence of spontaneous abortion in Yimeng mountain area was 1.5%.The effect factors of spontaneous abortion included living environment, occupation and educational level of pregnant women, the age, educational level, smoking and drinking habits of their husbands, suffering from diseases now and anamnesis, the histories of abnormal pregnancy and abortion; having a fever during first trimester of pregnancy, contacting pets during second and third trimester of pregnancy could induce spontaneous abortion.Conclusion: The histories of abnormal pregnancy and abortion are the main risk factors of spontaneous abortion; the pregnant women with high educational level have low incidence of spontaneous abortion.%目的:探讨沂蒙山区自然流产的发生率及自然流产的主要原因.方法:采用随机整群抽样,进行回顾性流行病学调查,对沂蒙山区2006年1月1日~2008年6月30日发生的自然流产夫妇的相关资料进行分析.结果:沂蒙山区的自然流产率为1.5%.孕妇本人居住环境、职业、文化程度及配偶年龄、文化程度、吸烟嗜好,孕妇现患病、既往患病、既往异常妊娠流产史可影响自然流产的发生;孕早期发烧,孕早期、孕中期接触宠物等可导致自然流产.结论:既往异常妊娠流产史是主要的自然流产的危险因素;孕妇文化程度越高,自然流产发生率越低.

  14. 肥胖在流产中的作用研究新进展%Obesity and Spontaneous Abortion

    2014-01-01

    妊娠妇女肥胖与流产之间的关系日益受到关注。对于因不孕接受治疗的女性,肥胖者发生流产的机会增加。肥胖女性应在体质量得到有效控制后再考虑妊娠;对于自然妊娠的女性,肥胖亦会增加流产风险。多数研究表明,肥胖导致的内分泌功能紊乱是引发流产的主要机制,肥胖患者多数存在高胰岛素血症及胰岛素抵抗(IR),其中Ⅰ型纤溶酶原激活剂抑制物(PAI-1)、雄激素、胰岛素样生长因子等分别在发病机制中起不同作用。另外,子宫内膜容受性降低、子宫内膜血流减少、染色体核型异常等也是肥胖导致流产的原因。综述肥胖在流产中的作用机制。%Gestational obesity and correlative abortion are becoming the focus. In those infertile women, obese women have higher risk of abortion. So, obese women are suggested to control well their weight before pregnancy. In those women with natural pregnancy, obese women have also increased risk of abortion. Most studies showed that the endocrine disorders related with obesity were the main mechanism of abortion. Most obese patients are accompanied with hyperinsulinism and insulin resistance, while the plasminogen activator inhibitor-1 (PAI-1), androgen and insulin-like growth factor play different roles in the pathophysiology. In addition, the decreased uterine receptivity, the reduced endometrial blood flow and abnormal karyotype are reasons of abortion in obese women. In this paper, the mechanism of abortion in obese women was reviewed.

  15. 肥胖在流产中的作用研究新进展%Obesity and Spontaneous Abortion

    2014-01-01

    Gestational obesity and correlative abortion are becoming the focus. In those infertile women, obese women have higher risk of abortion. So, obese women are suggested to control well their weight before pregnancy. In those women with natural pregnancy, obese women have also increased risk of abortion. Most studies showed that the endocrine disorders related with obesity were the main mechanism of abortion. Most obese patients are accompanied with hyperinsulinism and insulin resistance, while the plasminogen activator inhibitor-1 (PAI-1), androgen and insulin-like growth factor play different roles in the pathophysiology. In addition, the decreased uterine receptivity, the reduced endometrial blood flow and abnormal karyotype are reasons of abortion in obese women. In this paper, the mechanism of abortion in obese women was reviewed.%妊娠妇女肥胖与流产之间的关系日益受到关注。对于因不孕接受治疗的女性,肥胖者发生流产的机会增加。肥胖女性应在体质量得到有效控制后再考虑妊娠;对于自然妊娠的女性,肥胖亦会增加流产风险。多数研究表明,肥胖导致的内分泌功能紊乱是引发流产的主要机制,肥胖患者多数存在高胰岛素血症及胰岛素抵抗(IR),其中Ⅰ型纤溶酶原激活剂抑制物(PAI-1)、雄激素、胰岛素样生长因子等分别在发病机制中起不同作用。另外,子宫内膜容受性降低、子宫内膜血流减少、染色体核型异常等也是肥胖导致流产的原因。综述肥胖在流产中的作用机制。

  16. Study of methyl transferase (G9aMT) and methylated histone (H3-K9) expressions in unexplained recurrent spontaneous abortion (URSA) and normal early pregnancy.

    Fatima, Nishat; Ahmed, S H; Salhan, Sudha; Rehman, S M F; Kaur, Jatinder; Owais, M; Chauhan, Shyam S

    2011-11-01

    We investigated the expression of methyl transferase G9a and methylated histone H3-K9 in fresh human decidual/endometrial tissue of 12 normal early pregnancies and 15 unexplained recurrent spontaneous abortions (URSA). The samples were obtained through dilatation and curettage and collected as per strict inclusion-exclusion criteria. The tissue was subjected to immunohistochemical analysis (IHC), western blotting (WB) and RT-PCR analysis. The results demonstrated methyl transferase G9a to have a lower expression in abortions when compared with that in normal pregnancy (P < 0.05). The sensitivity of RT-PCR, IHC and WB were respectively 66.67, 75 and 71.43%, while specificity of the same were 66.67, 60 and 78.92%, respectively. Methylated histone H3-K9 was significantly lower (P < 0.0001) in URSA tissues than in controls. This study suggests that methylation may cause URSA and indicates the need for further work to explore the role of methylation in URSA and its possible prevention through locally acting methylating/demethylating agents. PMID:21606120

  17. Increasing the risk of spontaneous abortion and major malformations in newborns following use of serotonin reuptake inhibitors during pregnancy: A systematic review and updated meta-analysis

    Nikfar Shekoufeh

    2012-11-01

    Full Text Available Abstract Selective serotonin reuptake inhibitors (SSRIs are the most frequently used antidepressants during pregnancy. There are conflicting results about their influence on pregnancy outcomes. The goal of this study was to update our previous meta-analysis about pregnancy outcomes following exposure to SSRIs. For this purpose, all relevant databases were searched from 1990 to March 2012 for studies investigating the pregnancy outcomes following exposure to any therapeutic dosage of any SSRI (fluoxetine, paroxetine, citalopram, escitalopram, sertraline, fluvoxamine during pregnancy. Types of outcome investigated were spontaneous abortion, major malformations, cardiovascular malformations, and minor malformations. A total of 25 studies met our criteria and were included in the meta-analysis. The odds ratio (OD values are 1.87 (95% CI: 1.5 to 2.33, P

  18. Annexin A5 haplotype M2 is not a risk factor for recurrent spontaneous abortion in Northern Europe: is there sufficient evidence?

    Markoff, Arseni; Kurahashi, Hiroki; Grandone, Elvira; Bogdanova, Nadja

    2016-05-01

    The M2 haplotype of the annexin A5 gene is a well-recognized predisposition factor for recurrent spontaneous abortion (RSA). A recent publication by Nagirnaja et al. (2015) in PLoS One discusses the risk role of the M2 haplotype for RSA in cases compared with controls of North European extraction and arrives at a negative result. As a number of previous and fairly recent studies have supported the proposed involvement of the M2 haplotype in the cause of idiopathic RSA, this commentary aims to highlight problematic issues in the above publication. It is the opinion of the authors that the study by Nagirnaja et al. (2015) does not generate adequate proof of the absence of RSA risk, attributable to carriage of the M2 haplotype. PMID:26966050

  19. Increasing the Risk of Spontaneous Abortion and Major Malformations in Newborns Following Use of Serotonin Reuptake Inhibitors during Pregnancy: a Systematic Review and Updated Meta-Analysis

    Mohammad Abdollahi

    2012-11-01

    Full Text Available Selective serotonin reuptake inhibitors (SSRIs are the most frequently used antidepressants during pregnancy. There are conflicting results about their influence on pregnancy outcomes.The goal of this study was to update our previous meta-analysis about pregnancy outcomes following exposure to SSRIs. For this purpose, all relevant databases were searched from 1990 to March 2012 for studies investigating the pregnancy outcomes following exposure to any therapeutic dosage of any SSRI (fluoxetine, paroxetine, citalopram, escitalopram, sertraline, fluvoxamine during pregnancy. Types of outcome investigated were spontaneousabortion, major malformations, cardiovascular malformations, and minor malformations. A total of 25 studies met our criteria and were included in the meta-analysis. The odds ratio (OD values are 1.87 (95% CI: 1.5 to 2.33, P< 0.0001 for spontaneous abortion, 1.272 (95%CI: 1.098 to 1.474, P = 0.0014 for major malformations, 1.192 (95% CI: 0.39 to 3.644, P=0.7578 for cardiovascular malformations, and 1.36 (95% CI: 0.61 to 3.04, P= 0.4498 for minor malformations. The results demonstrated that SSRIs increase the risk of spontaneousabortion and major malformations during pregnancy while they don’t increase the risk of cardiovascular malformations and minor malformations. Our previous meta-analysis only showed an increase in the risk of spontaneous abortion following the use of SSRIs duringpregnancy. This might be due to increase in the number of studies included or addition of two new SSRIs (citalopram and escitalopram. The message to researchers is to try considering SSRIs individually during pregnancy to reduce heterogeneity, although all are aware ofinevitable limitations to study on pregnant mothers.

  20. The balance of the immune system between HLA-G and NK cells in unexplained recurrent spontaneous abortion and polymorphisms analysis.

    Arjmand, Fateme; Ghasemi, Nasrin; Mirghanizadeh, Seyed Ali; Samadi, Morteza

    2016-06-01

    Human leukocyte antigen (HLA)-G is involved in immunoregulatory processes and particularly in pathogenesis of inflammatory disorders such as recurrent spontaneous abortions (RSA). The purpose of the current study was to examine whether two single nucleotide polymorphisms (SNPs) of HLA-G gene (rs1736936 and HLA-G*0105N) influence susceptibility to recurrent spontaneous abortion. Genomic DNA from 117 RSA patients and 117 normal fertile control individuals was isolated using the salted out method. The two single nucleotide polymorphisms in HLA-G gene were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Differences between the two groups were analyzed by SPSS19 software using Chi-square test. The results revealed a significant increase in HLA-G*0105N allele in the proportion of whole group of RSA women compared with fertile controls (P value = 0.015), OR (95 % CI) = 2.054 (1.798-2.347), as well as an absence of homozygosity for HLA-G*0105N in the study population. No significant difference was observed between the RSA and the fertile groups in terms of alleles and genotypes frequency of rs1736936 (P value = 0.323), OR (95 CI %) = 1.056 (0.844-1.319). The presented data suggest that the investigated HLA-G*0105N allele is potentially associated with RSA through linkage disequilibrium with other genetic elements. Meanwhile, the rs1736936 SNP do not predispose to RSA in the study population. PMID:26754761

  1. Abordagem citogenética e molecular em material de abortos espontâneos Cytogenetic and molecular evaluation of spontaneous abortion samples

    Andréa Cristina de Moraes

    2005-09-01

    Full Text Available OBJETIVOS: avaliar o desempenho da citogenética e das técnicas de hibridização in situ fluorescente (FISH e reação em cadeia da polimerase (PCR no estudo das aneuploidias cromossômicas numéricas e na determinação do sexo fetal em amostras de abortos espontâneos. MÉTODOS: duzentos e dezenove amostras de produtos de abortos espontâneos foram submetidas a estudo citogenético. Deste total, 40 amostras foram também submetidas à técnica de PCR-nested para a determinação do sexo fetal: 32 foram selecionadas devido à falha de crescimento no estudo citogenético e oito foram escolhidas ao acaso. Vinte amostras foram selecionadas para detecção de aneuploidias cromossômicas pela técnica de FISH, utilizando-se sondas para os cromossomos 13, 18, 21, X e Y: 13 casos foram submetidos a FISH devido à falha de crescimento no estudo citogenético e sete foram escolhidos ao acaso. Foi calculada a taxa de sucesso (obtenção de cariótipo de cada técnica. Para comparação das taxas de sucesso foi utilizado o teste de chi2, sendo considerados significantes resultados com pPURPOSE: to evaluate the performance of cytogenetic analysis, fluorescent in situ hybridization (FISH and polymerase chain reaction (PCR in the study of numerical chromosomal anomalies and in fetal sex determination of spontaneous abortion material. METHODS: cytogenetic analysis was performed on 219 spontaneous abortion specimens. Forty of these cases were also submitted to fetal sex determination using nested-PCR. Thirty-two of these cases were selected due to failed cytogenetic culture and the other eight were selected randomly. Twenty samples were submitted to the FISH technique, using probes for chromosomes 13, 18, 21, X and Y. Thirteen of these samples were selected due to failed cytogenetic culture and the other seven were randomly selected. The success rates of each technique were compared using the chi2 test and an established p<0.05 level of significance. The

  2. A critical update on endothelial nitric oxide synthase gene variations in women with idiopathic recurrent spontaneous abortion: genetic association study, systematic review and meta-analyses.

    Pereza, N; Peterlin, B; Volk, M; Kapović, M; Ostojić, S

    2015-05-01

    A number of case-control studies investigated the association between idiopathic recurrent spontaneous abortion (IRSA) and variations in the gene encoding endothelial nitric oxide synthase (NOS3), but yielded contradictory results. Our aim was to test the association of the NOS3 variable number of tandem repeats (VNTR) in intron 4 and +894 G/T single-nucleotide polymorphism (SNP) with IRSA in Slovenian women (148 IRSA and 149 control women), conduct a systematic review of literature on the association between NOS3 gene variations and IRSA, and perform meta-analyses of studies that met the inclusion criteria, defined by virtue of the European Society for Human Reproduction and Embryology evidence-based guidelines for recurrent spontaneous abortion. Genotyping was performed using PCR and restriction fragment length polymorphism methods. The systematic review of literature (English language) was conducted using PubMed and Scopus databases, to 1 November 2014. We determined no association of IRSA with the VNTR in intron 4 and +894 G/T SNP in Slovenian women. Furthermore, 16 case-control studies were identified on the association between 15 NOS3 gene variations and IRSA. However, significant inconsistencies exist in the selection criteria of patients and controls between studies. The meta-analysis of VNTR in intron 4 was performed on five studies (894 patients, 944 controls), whereas the meta-analysis of +894 G/T SNP included six studies (1111 patients, 1121 controls). The association with IRSA was significant for the +894 G/T SNP under the dominant genetic model (GT+TT versus GG) based on fixed (odds ratio (OR) = 1.54, 95% confidence interval (CI) = 1.28-1.86, P = <0.01) and random effects models (OR = 1.54, 95% CI = 1.03-2.31, P = 0.03). In conclusion, the GT and TT genotypes of the +894 G/T SNP in women might contribute to a predisposition to IRSA. Additional genetic association and functional studies in different populations with larger numbers of participants and a

  3. Active suppression of host-vs-graft reaction in pregnant mice. VII. Spontaneous abortion of allogeneic CBA/J x DBA/2 fetuses in the uterus of CBA/J mice correlates with deficient non-T suppressor cell activity

    The mammalian fetus has been viewed as an unusually successful type of allograft and unexplained spontaneous abortion as a possible example of maternal rejection. Previous studies have shown the presence of small lymphocytic suppressor cells in the murine decidua which block the generation and reactivation of anti-paternal cytotoxic T lymphocytes (CTL) and lymphokine-activated killer cells (LAK) by elaborating a factor that inhibits the response to interleukin 2 (IL 2). A deficiency of these suppressor cells was associated with implants of xenogeneic Mus caroli embryos in the Mus musculus uterus which are infiltrated by maternal lymphoid cells and aborted. A deficiency of such suppressor cells in the lymph nodes draining the uterus of CBA/J females in the process of aborting their semi-allogeneic CBA x DBA/2 F1 progeny has also been shown. CBA/J females possess significantly lower levels of decidua-associated non-T suppressor cells on day 8.5 to 10.5 of allopregnancy than do mothers that will produce large litters of live babies. The F1 embryos are infiltrated by maternal lymphocytes prior to abortion, and the infiltration and abortion rate appears to be augmented by pre-immunization with paternal DBA/2 spleen cells. The CBA/J x DBA/2J mating combination provides a model of spontaneous abortion in which immunologic factors play an important role and demonstrates that the association between deficiency of decidua-associated suppressor cells and xenopregnancy failure also holds true for the failure of allopregnancies resulting from natural within-species mating

  4. Familial reciprocal translocation t(8;17(p23;q21 in a woman with recurrent spontaneous abortion

    Shadi F. Al-Ashi

    2013-08-01

    Full Text Available This work presents the results of cytogenetic analysis of a couple referred to our genetics laboratory with ten first trimester abortions and one IVF failure. The male showed a normal (46, XY karyotype whereas the female was found to carry an apparently balanced reciprocal translocation [46, XX, t(8;17(p23;q21]. Two sisters and two brothers of the eight siblings of the female proved to have the same translocation. Although the female\\'s father is deceased and his sample was not available for investigation. The origin of this translocation must be paternal since the female\\'s mother harbored a normal karyotype. It is concluded that the history of recurrent pregnancy losses in the couple is due to the production of unbalanced gametes in the female as a result of the reciprocal translocation she has and the couple was advised to undergo a PGD for embryo selection prior to their future IVF trials. The authors also recommend that all RSA couples with normal routine work-up results should be offered chromosomal analysis without delay. [Int J Reprod Contracept Obstet Gynecol 2013; 2(4.000: 695-697

  5. A SNP in pri-miR-10a is associated with recurrent spontaneous abortion in a Han-Chinese population.

    Li, Ying; Wang, Xue-Qin; Zhang, Lu; Lv, Xiao-Dan; Su, Xing; Tian, Shi; Liu, Chun-Mei; Ma, Xu; Xia, Hong-Fei

    2016-02-16

    MicroRNA-10a (miR-10a) has a wide range of functions in nearly all mammalian tissues and is involved in the occurrence of many diseases. However, it remains unknown whether miR-10a is associated with human recurrent spontaneous abortion (RSA). In this study, we found that rs3809783 A > T in miR-10a coding region was significantly associated with the increase of the risk of human unexplained RSA (URSA) acquisition in a Han-Chinese population. The T allele of rs3809783 hindered the production of mature miR-10a. A to T substitution in miR-10a rs3809783 repressed cell proliferation and migratory capacity. Further investigation discovered that Bcl-2-interacting mediator (Bim) was the functional target of miR-10a and inversely regulated Bim expression. Dual-luciferase assay indicated that A allele in miR-10a rs3809783 could more effectively suppress Bim expression than T allele. In addition, A to T substitution in miR-10a rs3809783 attenuated the sensibility of cells to progesterone and its antagonist mifepristone. Collectively, our data suggest that rs3809783 A > T in pri-miR-10a may be conductive to the genetic predisposition to RSA by disrupting the production of mature miR-10a and reinforcing the expression of Bim. PMID:26824181

  6. The research progress in immune factors correlating with recurrent spontaneous abortion%反复流产免疫因素的研究进展

    司马玲

    2011-01-01

    Recurrent spontaneous abortion (RSA) is a common and frequently encountered disease in department of gynecology.It brings about heavy spirit and economy burdens for patients and families. Its causes are very complicated. Except of heredity, endocrine, abnormality of reproductive organ and infection factors, RSA is concerned with immunity factor about 40 ~50 percent. Recently studies consider that immunity factor is a significant reason. Therefore, to deep research is necessary to achieve directive treat.This text is a review about immunity factor of RSA and recently research.%反复自然流产(RSA)是妇科常见病、多发病,给患者、家庭带来了沉重的精神和经济负担,其病因十分复杂,除了遗传、内分泌、生殖器官异常及感染等因素外,40%~65%与免疫因素有关,近年来的研究认为免疫因素是导致RSA的重要原因,有必要对其进行深入研究,以作针对性治疗.本文对反复流产的免疫因素及近年来的研究进展进行综述.

  7. 复发性流产与宫颈HPV感染的相关性分析%Correlation Analysis of HPV Infection and Pregnancy Recurrent Spontaneous Abortions

    钟小敏

    2015-01-01

    目的:探讨复发性流产与宫颈HPV感染的相关性。方法:将本站妇科门诊就诊的早期复发性流产(RSA)98例患者作为实验组,同时期妊娠的非RSA女性95例为对照组,采用PCR法对两组患者进行宫颈HPV基因检测,对比两组患者HPV感染的阳性率及各亚型在HPV感染中的比例。结果:实验组中HPV阳性34例(34.7%),对照组HPV阳性12例(12.6%),实验组HPV阳性率显著高于对照组(χ2=16.186, P0.05);HPV阳性与RSA发生呈正相关性(r=0.259,P0.05).There was significant positive correlation between HPV-positive and RSA occur (r=0.259,P<0.001).Conclusion:Early pregnancy recurrent spontaneous abortions is associated with HPV infection closely, HPV may be involved in the occurrence of RSA.

  8. Usual hospital care versus post-abortion care for women with unsafe abortion: a case control study from Sri Lanka

    Arambepola, Carukshi; Lalini C. Rajapaksa; Galwaduge, Chandani

    2014-01-01

    Background Good quality post-abortion-care (PAC) is essential to prevent death and long-term complications following unsafe abortion, especially in countries with restrictive abortion laws. We assessed the PAC given to women following an unsafe abortion, compared to the routine hospital care following spontaneous abortion or unintended pregnancy carried to term in Sri Lanka. Methods A case–control study was conducted in Sri Lanka among 171 cases following unsafe abortion, 638 controls followi...

  9. In 17l couples with spontaneous abortion chromosome karyotype analysis%玉林地区171对自然流产夫妇染色体核型分析

    邓国生; 张炬光; 何娟

    2013-01-01

    Objective:To study the relationship between spontaneous abortion and abnormal chromosome karyotype.Methods:Atotal of 171 couples with spontaneous abortions in the peripheral slices karyotype chromosome abnormal status statistics.Results:In 171 couples with spontaneous abortion,abnormal chromosome karyotype in 20 cases,abnormal chromosome karyotype detection rate was 5.87% (20 / 342),In 20 patients with abnormal karyotype of chromosome translocation in 4 robersonian translocation (20%)robertson; 3 cases of reciprocal translocation (15 %) ; Chromosomal inversions in 7 cases (35 %) ; mosaic in 1 cases (5 %) ; Chromosome polymorphism in 5 cases (25%).With the increase of times of spontaneous abortion,karyotypic abnormalities in the proportion of the increase,the proportion had statistical significance.Conclusion:spontaneous abortion pregnant women and couples with chromosomal abnormalities are closely related.%目的 探讨自然流产与染色体核型异常关系.方法 对171对自然流产夫妇的外周血行染色体核型检查统计染色体核型异常状况.结果 171对自然流产夫妇中,染色体核型异常共20例,染色体核型异常检出率5.87% (20/342),20例异常核型中染色体罗伯逊易位4例(20%);相互易位3例(15%);染色体倒位7例(35%);嵌合体1例(5%);染色体多态5例(25%).随自然流产次数的增加,核型异常所占比例增加,其构成比具有统计学意义.结论 自然流产与孕妇夫妇染色体异常核型密切相关.

  10. Abortion: the hidden plague.

    Tuckwell, S

    1974-05-01

    Abortion is called the invisible plague of all countries and cultures in the twentieth century. It is by far the most important method of birth control in the world today. For every 200 babies born there are at least 100 abortions. In the rich world, a woman who wants to end her pregnancy goes to an abortionist, but for millions of poor women, abortion happens spontaneously in their own homes induced by poor nutrition, sheer physical weakness, and too many pregnancies too close together. In countries where abortion is illegal, millions of women die each year as a result of severe illness or the botched handiwork of backyard operators. The most common complications are massive hemorrhaging, perforation of the uterus, laceration, sepsis, and renal failure. The experience of a great many countries shows that simply legalizing abortion can lead to a dramatic drop in death and illness. Relaxation of abortion laws can save lives, money, and misery for mothers and children. Illegal abortion has become a major problem in Africa there are 3 main types of women who enter hospitals with complications after abortions: 1) the teenager who is away from home; 2) the young woman, often educated, working, and with financial responsibilities, who is ambitious for herself, her husband, or her family; and 3) the woman in her thirties, illiterate, a rural worker, married most of her reproductive life, and pregnant most years. The third type of woman may abort because her system is utterly depleted. Such women must be shown that there is a good chance of survival for her children so that she will not have so many. PMID:12307249

  11. A shift in the balance of T17 and Treg cells in menstrual blood of women with unexplained recurrent spontaneous abortion.

    Hosseini, Samira; Shokri, Fazel; Ansari Pour, Soheila; Jeddi-Tehrani, Mahmood; Nikoo, Shohreh; Yousefi, Mehdi; Zarnani, Amir-Hassan

    2016-08-01

    To determine usefulness of menstrual blood for assessment of differential frequency of T cell subsets, peripheral blood (PB) and menstrual blood (MB) from healthy fertile (n=15), unexplained recurrent spontaneous abortion (URSA) women (n=15) and unexplained infertile women (n=8) were collected in the second day of menstrual bleeding. Frequency of T cell subsets was measured by flow cytometry. URSA and unexplained infertile patients had higher frequency of TCRαβ(+)CD3(+)CD56(-) and CD45RO(+) T cells as well as CD45RO(+)/CD45RO(-) ratio in PB as compared to MB. Frequency of CD3(+)TCRγδ(+) cells in PB of unexplained infertile and MB of URSA patients were significantly lower than that in fertile group. In all groups MB contained higher percentage of CD4(+)CD25(+)Foxp3(+) regulatory and lower percentages of CD16(+) T cells compared to PB. T17 cells (CD3(+)CD56(-)IL-17(+)) was found to be significantly higher in MB of only fertile and unexplained infertile subjects and not URSA patients in comparison with PB. Compared to PB, only fertile women had higher T17:Treg ratio in their MB. URSA women had significantly lower MB T17 cells and T17:Treg ratio compared to those in fertile and unexplained infertile women. Based on the findings presented here, we speculate that MB has its own unique immune milieu which is not solely continuation of the immune environment of secretory endometrium. Indeed, immunophenotyping of MB immune cells could potentially be a useful tool for investigation of immunological disturbances in pregnancy-related disorders. PMID:27128988

  12. Reproductive Hazards Still Persist in the Microelectronics Industry: Increased Risk of Spontaneous Abortion and Menstrual Aberration among Female Workers in the Microelectronics Industry in South Korea.

    Inah Kim

    Full Text Available Despite the global expansion of supply chains and changes to the production process, few studies since the mid-1990 s and 2000s have examined reproductive risks of the microelectronics industry; we examined the reproductive risks among female microelectronics workers in South Korea.Based on claim data from the National Health Insurance (2008-2012, we estimated age-specific rates of spontaneous abortion (SAB and menstrual aberration (MA among women aged 20 to 39 years. We compared data between microelectronics workers and three different control groups: economically inactive women, the working population as a whole, and workers employed in the bank industry. For an effect measure, age-stratified relative risks (RRs were estimated.Female workers in the microelectronics industry showed significantly higher risk for SAB and MA compared to control groups. The RRs for SAB with reference to economically inactive women, working population, and bank workers in their twenties were 1.57, 1.40, and 1.37, respectively, and the RRs for MA among females in their twenties were 1.54, 1.38, and 1.48, respectively. For women in their thirties, RRs for SAB were 1.58, 1.67, and 1.13, and those for MA were 1.25, 1.35, and 1.23 compared to the three control populations, respectively. All RRs were statistically significant at a level of 0.05, except for the SAB case comparison with bank workers in their thirties.Despite technical innovations and health and safety measures, female workers in microelectronics industry in South Korea have high rates of SAB and MA, suggesting continued exposure to reproductive hazards. Further etiologic studies based on primary data collection and careful surveillance are required to confirm these results.

  13. An increase in vascular endothelial growth factor (VEGF and VEGF soluble receptor-1 (sFlt-1 are associated with early recurrent spontaneous abortion.

    Lihong Pang

    Full Text Available Recurrent spontaneous abortion (RSA is a health problem that affects approximately 1% to 5% reproductive age woman. Yet, in around half of these patients, the mechanism for RSA is unexplained. Recent studies have indicated that placental ischemia/hypoxia and endothelial dysfunction are important factors in miscarriage. Other studies have indicated that the level and expression of soluble FMS-like tyrosine kinase-1 (sFlt1 is increased under a hypoxic environment. However, decreased sFlt-1 in the maternal circulation during the first trimester has recently been proposed as a potential marker for identifying risk of pregnancy loss. In this prospective study clinical samples were obtained within a short time after the fetal death, protein expression and maternal serum levels of sFlt1 were assessed and compared to samples taken from those with normal pregnancies. Our results indicate that levels of VEGF and sFlt-1 are both increased in women during early pregnancy compared women that are not pregnant (p<0.05 indicating that VEGF and sFlt-1 are both associated with pregnancy. More importantly, we detected a significant (p<0.05 increase in sFlt1 and VEGF levels and expression in the RSA patients who suffered subsequent miscarriages compare to controls. These results demonstrate that there is likely a relationship between VEGF, sFlt-1 and RSA suggesting that the high levels and over expression of sFlt-1 and VEGF might be associated with the pathogenesis of RSA.

  14. Study on correlation between pressure, social support and depression for spontaneous abortion patients%自然流产患者抑郁与压力和社会支持的相关性研究

    陆美英; 陈燕

    2012-01-01

    Objective To study the correlation between pressure, social support and depression for spontaneous abortion patients. Method Assess and analyze 286 spontaneous abortion patients by correlated variables of patients' general information, Beck Depression Inventory, Perceived Pressure Scale and Social Support Rating Scale (SSRS). Result Rate of depression is 30. 42% among spontaneous abortion patients. Pressure score is obviously higher in depression group than in non-depression group. The total score of social support and three dimension scores arc lower in depression group. Score of depression has positive correlation with score of pressure and negative correlation with score of social support. Result of multiple stepwisc regression analysis shows that patients' age, times of abortion, length of gestational age, pressure, social support, spouse affection and family relationship arc the main factors influencing patients' depression. Conclusion Spontaneous abortion patients have huge mental pressure and low social support, who arc easily complicated with depression.%目的 探讨自然流产患者抑郁与压力和社会支持的相关性.方法 采用患者一般情况相关变量、Beck抑郁问卷、领悟压力量表及社会支持评定量表对286例自然流产患者进行测评及分析.结果 自然流产患者的抑郁发生率为30.42%;抑郁组压力评分明显高于非抑郁组,社会支持总分及3维度评分低于非抑郁组;抑郁与压力评分呈正相关,与社会支持评分呈负相关;多元逐步回归分析结果显示患者年龄、流产次数、孕周大小、压力、社会支持、夫妻感情、家人关系等是影响患者抑郁的主要因素.结论 自然流产患者心理压力大、社会支持度低,易并发抑郁.

  15. Women and men’s psychological adjustment after abortion: a six months prospective pilot study

    Canário, Catarina; Figueiredo, Bárbara; Ricou, Miguel

    2011-01-01

    Background: The psychological impact of abortion is a controversial issue. While some studies indicate that women who had elective abortions present lower psychological distress when compared with those who had spontaneous or therapeutic abortions, other studies found abortion to be associated with significant psychological distress. Objectives: To assess psychological adjustment (emotional disorder, trauma symptoms and couple relationship) one and six months after abortion,...

  16. Detección de Neospora caninum en fetos bovinos abortados espontáneamente en el nordeste argentino Neospora caninum detection in spontaneously aborted bovine fetuses from Argentine northeast

    W.J. Lertora

    2010-12-01

    Full Text Available El objetivo del presente trabajo fue detectar Neospora caninum en neonatos y fetos bovinos de abortos espontáneos del nordeste argentino. Sobre un total de 26 fetos bovinos abortados espontáneamente (23 de cría y 3 de tambo se detectaron lesiones histopatológicas compatibles con neosporosis en 4 de ellos. La presencia de Neospora caninum fue confirmada mediante inmunohistoquímica en el encéfalo de 3/4 fetos (2 de cría y 1 de tambo con lesiones microscópicas compatibles con neosporosis. Las lesiones histopatológicas más relevantes fueron la asociación de encefalitis, miocarditis y hepatitis no purulenta multifocales. De 10 neonatos bovinos procesados (8 de cría y 2 de tambo, no se detectaron animales con lesiones compatibles con neosporosis. Este trabajo confirma la presencia de Neospora caninum en fetos abortados espontáneamente en bovinos de rodeos de cría y de tambo del nordeste argentino.The aim of this work was to detect the presence of Neospora caninum in bovine neonates and bovine spontaneous abortions from Argentine northeast. Histopathological lesions compatible with neosporosis were found in 4 of 26 bovine spontaneous abortions (23 beef herds and 3 dairy herds. The Neospora caninum presence was confirmed with immunohistochemical analysis in encephalic tissue in 3 of 4 fetuses (2 beef herds and 1 dairy herd that displayed microscopical lesions of neosporosis. Multifocal non-purulent encephalitis, myocarditis and hepatitis were the most relevant lesions. There were no lesions of neosporosis in 10 bovine neonates (8 beef herds and 2 dairy herds. This work confirms the presence of Neospora caninum in spontaneous bovine abortions of beef herds and dairy herds of the Argentine northeast.

  17. 自然流产胚胎染色体数目异常的临床研究%Clinical research on chromosomal numerical abnormality in embryos of spontaneous abortion

    韦红卫; 杜娟; 陈科; 蒋丽; 谭芸; 白华; 夏红卫; 莫云

    2012-01-01

    Objective: To explore the relationship between chromosomal numerical abnormality and spontaneous abortion, analyze the influencing factors of spontaneous abortion. Methods: Fluorescent in situ hybridization technique was used to detect the chromosomal number in chorionic villus of one hundred cases with early spontaneous abortion, then the relationship between chromosomal number and spontaneous abortion was analyzed. Results: Among 100 cases, 42 cases were found with chromosomal numerical abnormality, accounting for 42. 00% ; 16 cases were found with chimera, accounting for 16.00%. The most common chromosomal abnormality was triploid, accounting for 35. 71% , followed by 45, X and trisomy 16, accounting for 16.67% and 14. 29% , respectively. The detection rate of chromosomal abnormality in advanced age group (3=35 years) was 45.46% (10/22), while the detection rate of chromosomal abnormality in non - advanced age group ( 0.05) . The detection rate of chromosomal abnormality in the cases with history of spontaneous abortion was 42.55% (20/47), while the detection rate of chromosomal abnormality in the cases without history of spontaneous abortion was 41.51% ( 22/53), there was no significant difference ( P > 0. 05) . The detection rate of chromosomal abnormality in the cases of S10 gestational weeks was 45.00% (27/60), while the detection rate of chromosomal abnormality in the cases of > 10 gestational weeks was 37.50% (15/40) , there was no significant difference (P >0.05) . Conclusion; Chromosomal abnormality is the main cause of early spontaneous abortion, regardless of maternal age, previous history of spontaneous abortion or not, and gestational weeks, the cases with spontaneous abortion at this time may be associated with chromosomal abnormality. Clinicians should pay more attention to chromosomal examination, in order to provide genetic counseling for subsequent pregnancy.%目的:探讨染色体数目异常与自然流产的关系及其影响因素.方法:

  18. APPLICATION OF HORMONE ADJUSTMENT IN TREATMENT OF RECURRENT SPONTANEOUS ABORTION%激素调整在复发性流产保胎治疗中的应用

    商微; 王蔼明; 吕立波; 张雷; 舒明明; 赵勇

    2014-01-01

    目的:通过排卵后即开始对复发性流产患者的激素水平进行调整,探讨一种安全、高效、实用的临床保胎方案。方法选取复发性流产患者172例。所有患者自然流产均发生在孕12周或孕12周之前,并均有孕酮保胎失败史。排卵后开始根据测定的激素水平给予相应的外源性雌激素、孕激素和(或)促黄体生成素进行保胎治疗并定期检测激素水平,看到胎心时开始逐渐减量,观察至孕12周,随访至出生后3个月。结果复发性流产患者孕早期保胎成功率为95.32%。结论从排卵后即开始有针对性地进行激素调整保胎治疗可以提高孕早期保胎成功率。%OcjectiVe To discuss a safe,efficient and practical clinical miscarriage plan,by adjusting the hormone levels of recurrent spontaneous abortion patients after ovulation. Methods The study enrolled 171 recurrent spontaneous abortion patients and all patients with spontaneous abortion occurred before 12 weeks or 12 weeks of pregnancy,and had a history of progesterone abortion failure. On the basis of the determined hormone levels,appropriate eXternally estrogen,progesterone and luteinizing hormone were used to prevent miscarriage after ovulation and the hormone levels were determined periodically. The dose began to reduce gradually when the fetal heart was observed until 12 weeks of pregnancy. Follow up lasted till three months after birth. Results Patients with recurrent miscarriage in early pregnancy miscarriage got the success rate 95. 32%by the treatment. Conclusion Targeted to adjustment hormone levels after ovulation can enhance the early stages of miscarriages success rate.

  19. 基因多态性与复发性自然流产的相关性研究%Study on the relationship between gene polymorphism and repeated spontaneous abortion

    李静益; 傅萍

    2012-01-01

    Repeated spontaneous abortion ( RSA) refers to abortions that occurred in succession two or more than two. The causes of RSA are complicated, including chromosomal abnormality of embryos, abnormal immune functions, luteal insufficiency, infection, genitourinary tract anomaly and so on. But now there are still some etiology and pathogenesis of RSA which are not clear, changes in genetic background and other facters may cause part of populations prone to RSA. Rerrent years some new points are put forward from the perspective of Immunology and Genetics, considering the causes of RSA are related with hereditary. Trying to find out susceptibility gene or pathogenic gene and clarifying the pathogenesis of RSA fundamentally, is important to the RSA treatment and prevention.%复发性自然流产(recurrent spontaneous abortions,RSA)是指连续发生2次或2次以上流产者.RSA的病因复杂,包括胚胎染色体异常、免疫功能异常、黄体功能不足、感染、生殖道异常等.但目前仍有部分RSA患者病因及发病机制尚不清楚,遗传背景等因素的改变可能使部分人群易发生RSA[1].近年来从免疫遗传角度提出了一些新的观点,认为RSA的发生与遗传有关.寻找RSA的易感基因或致病基因,从根本上阐明RSA的发病机理,是RSA治疗和预防的重要途径.

  20. A study on relationship be tween genital chlamydia trachomatis and ureaplasma urealyticum infection and spontaneous abortion%生殖道沙眼衣原体和解脲支原体感染与自然流产的相关性研究

    周萍

    2015-01-01

    目的:探讨生殖道沙眼衣原体和解脲支原体感染与自然流产的关系。方法选取我院自然流产患者(自然流产组)及人工流产患者(对照组),各60例。两组均采集宫颈分泌物及蜕膜组织进行沙眼衣原体和解脲支原体培养,分析结果。结果自然流产组宫颈分泌物及蜕膜组织中沙眼衣原体、解脲支原体、沙眼衣原体+解脲支原体感染率均高于对照组( P<0.01)。结论生殖道沙眼衣原体和解脲支原体感染率与自然流产关系密切,可作为确定自然流产病因的指标。%Objective To explore the corelation of genital chlamydia trachomatis and ureaplasma urealyticum infection with spontaneous abortion,and provide clinical reference for the prevention and control of spontaneous abortion .Methods Patients with spontaneous abortion were selected as spontaneous abortion group ( n =60) and artificial abortion group ( n =60), and cervical se-cretions and decidual tissue of chlamydia trachomatis and ureaplasma urealyticum were cultured and the results were analyzed .Results Infection rate of chlamydia trachomatis in cervical secretion of the natural abortion group ,ureaplasma urealyticum,chlamydia trachom-atis infection +UU rates of the natural abortion group were higher than that of the control group ( P <0.01).Conclusion Infection rate of genital chlamydia trachomatis and ureaplasma urealyticum infection rate and spontaneous abortion have a close relationship , which may be one of the causes of spontaneous abortion .

  1. 人微小病毒B19与自然流产的相关性研究%Correlation study between human parvovirus B19 and spontaneous abortion

    李春容; 黄菊青

    2012-01-01

    目的 探讨人微小病毒B19(HPV B19)与自然流产的相关性.方法 选取30例自然流产患者作为病例组.随机抽取30例同期正常妊娠的孕妇作为对照组.所有受试者均记录自然流产的潜在危险因素.抽取所有受试者肘静脉血,采用巢式聚合酶链反应法检测HPV B19 DNA,采用ELISA法检测HPV B19 IgM抗体.采用Logistic多元回归分析法进行多因素分析.结果 两组孕次≥2次,合并高血压、糖尿病,HPV B19 DNA阳性率比较差异有统计学意义[43.3%( 13/30)比13.3%(4/30)、33.3%( 10/30)比6.7%(2/30)、30.0% (9/30)比6.7%(2/30)、36.7%(11/30)比3.3%(1/30)](P<0.05);而HPV B19 IgM抗体阳性率比较差异无统计学意义(P>0.05).多因素分析显示,孕次≥2次、合并高血压、HPV B19 DNA阳性是孕妇发生自然流产的独立危险因素(OR=1.85、1.95、4.85,P<0.05).HPV B19 DNA阳性患者早期自然流产发生的风险明显高于晚期自然流产,差异有统计学意义(P<0.05).结论 HPV B19感染是自然流产患者的独立危险因素,需要早期检测并对妊娠孕妇进行必要的干预,以降低自然流产的发生.%Objective To investigate the correlation between human parvovirus (HPV) B19 and spontaneous abortion.Methods Participants included 30 cases of spontaneous abortion patients (patients group) and 30 normal pregnancy (control group).The potential risk of spontaneous abortion factors were recorded.Extracting all subjects cubits venous blood,HPV B19 DNA was tested by nested polymerase chain reaction,and HPV B19 IgM antibodies were determined by ELISA.The more factors analysis were performed by Logistic multiple regression analysis.Results There were significant differences in gravidity more than 2 times,combined with hypertension,combined with diabetes,HPV B19 DNA positive expression between patients group and control group [43.3%(13/30) vs.13.3%(4/30),33.3%(10/30) vs.6.7%(2/30),30.0% (9/30) vs.6.7% (2/30),36.7

  2. Appropriate Time for Hysteroscopic Examination after Spontaneous Abortion%自然流产后宫腔镜检查时机的探讨

    杨艳; 杜晓果; 马彩虹; 乔杰

    2012-01-01

    目的 探讨自然流产患者宫腔镜检查的临床应用价值. 方法 回顾分析我院2009年1月~2010年6月收治的462例有1次及以上自然流产史行宫腔镜检查的临床资料,对其宫腔镜检查的结果进行分析,对比1次、2次、3次及以上自然流产后宫腔镜检查的异常发生率,对其妊娠结局进行分析. 结果 462例中宫腔镜检查异常者占52.6% (243/462),其中子宫先天发育异常14.3% (66/462),以子宫不全中隔最常见8.7%(40/462);获得性子宫异常占38.3%(177/462),以宫腔粘连最常见17.1% (79/462).发生1次、2次、3次及以上自然流产患者分别占26.0%( 120/462)、41.1% (190/462)和32.9% (152/462).各组宫腔镜检查结果为正常、先天发育异常和获得性异常者分别占50.0%(60/120)、15.8%(19/120)和34.2% (41/120),48.4% (92/190)、14.2%( 27/190)和37.4%(71/190),以及44.1%(67/152)、13.2% (20/152)和42.8%(65/152),3组宫腔镜检查结果构成比无统计学差异(x2=2.272,P=0.686).在获得性子宫异常中,宫腔粘连在发生1次、2次、3次及以上自然流产患者发生率为34.1% (14/41)、42.3% (30/71)和53.8% (35/65),随流产次数增加而升高.术后随访率95.5%(441/462).1次、2次、3次及以上自然流产后进行宫腔镜检查治疗后再次流产率分别为0.8% (1/118)、2.7%(5/186)和9.5%(13/137),差异有显著性(x2=13.531,P=0.001).1次自然流产后进行宫腔镜检查治疗后再次妊娠超过28周占43.2% (51/118). 结论 宫腔镜检查是自然流产患者早期诊治的简单、准确及必要的手段,建议自然流产患者在1次流产后尽早进行宫腔镜检查,及早干预.%Objective To explore the incidence of uterine anomalies detected by hysteroscopy and the appropriate time for hysteroscopy examination after spontaneous abortion, as well as the outcomes of the patients who underwent the examination. Methods A retrospective study was conducted on 462 patients

  3. Medical abortion and the risk of subsequent adverse pregnancy outcomes

    Virk, Jasveer; Zhang, Jun; Olsen, Jørn

    2007-01-01

    identified all women living in Denmark who had undergone an abortion for nonmedical reasons between 1999 and 2004 and obtained information regarding subsequent pregnancies from national registries. Risks of ectopic pregnancy, spontaneous abortion, preterm birth (at <37 weeks of gestation), and low birth...... weight (<2500 g) in the first subsequent pregnancy in women who had had a first-trimester medical abortion were compared with risks in women who had had a first-trimester surgical abortion. RESULTS: Among 11,814 pregnancies in women who had had a previous first-trimester medical abortion (2710 women) or...... pregnancies, gestational age at abortion, parity, cohabitation status, and urban or nonurban residence, medical abortion was not associated with a significantly increased risk of ectopic pregnancy (relative risk, 1.04; 95% confidence interval [CI], 0.76 to 1.41), spontaneous abortion (relative risk, 0.87; 95...

  4. Role of lymphocyte immunotherapy in recurrent implantation failure and recurrent spontaneous abortions%淋巴细胞免疫治疗在反复种植失败和复发性自然流产中的作用

    陈颖; 张建平

    2013-01-01

    The immunization therapy with allogeneic lymphocytes (lymphocyte immunotherapy, LIT)has been introduced for the treatment of infertile women with recurrent spontaneous abortions(RSA) for more than 30 years. To date,LIT has been used in different centers worldwide,although the efficacy and mechanism are still debating. From a theoretical point of view,there are several common aetiologies for recurrent implantation failure(RIF)and RSA during IVF treatment. Subsets of natural killer cells(NK)and T helper lymphocytes in peripheral blood have been reported to be associated with RIF and RSA. The hypothesis that RIF and RSA have partly identical aetiologies has been acknowledged, which leads to various immunotherapeutic interventions such as LIT to be tested.

  5. 3376例复发性流产夫妻染色体核型分析%Karyotype Analysis of 3 376 Cases of Recurrent Spontaneous Abortion Couples

    马京梅; 潘虹; 张慧婧; 付杰; 于丽; 齐雯; 杨慧霞

    2015-01-01

    目的:分析复发性流产( RSA)夫妻外周血染色体变异发生种类及其在男女性中的分布特点,为指导临床咨询及后续生殖干预提供依据。方法选取2007年9月—2014年8月在北京大学第一医院妇产科门诊主因RSA就诊的夫妻3376例,进行外周血染色体核型分析,比较染色体变异的发生率、种类、在男女性中的比例差异。结果 3376例RSA夫妻中发现染色体变异146例(4.32%),其中男85例,女61例,除去染色体多态性改变〔包括Y染色体变异(29例)、染色体次缢痕增加(28例)、D/G组染色体随体区变异(25例)及9号臂间倒位(21例)〕后,染色体异常共43例,其中相互易位最多见,为27例(62.79%),其次为罗氏易位5例(11.63%),倒位5例(11.63%),女性性染色体嵌合3例(6.98%),性反转综合征2例(4.65%),男性 Marker 染色体嵌合 1例(2.32%)。染色体多态性方面,男性以Y染色体变异最为多见(34.12%,29/85)。结论 RSA夫妻外周血染色体异常均有发生,染色体异常以相互易位为主,对以 RSA 原因就诊的夫妻,有必要同时对夫妻双方进行外周血染色体检查。%Objective To analyse the types and distribution characteristics of peripheral blood chromosomal variation among couples with recurrent spontaneous abortion ( RSA ), to provides guidance for clinical counseling and subsequent reproductive intervention. Methods A total of 3 376 cases of RSA couples who came to obstetrics and gynecology clinic of the First Hospital of Peking University from September 2007 to August 2014,were selected as study subjects,peripheral blood karyotype analysis was performed,the incidence,type and sex distribution were analyzed. Results Among 3 376 RSA cases, there were 146 cases with chromosomal variation ( 4. 32%)( 85 males and 61 females ) . After exclusion of chromosomal polymorphism〔(29 cases of Y chromosomal variation

  6. Immunologically mediated abortion (IMA).

    Giacomucci, E; Bulletti, C; Polli, V; Prefetto, R A; Flamigni, C

    1994-06-01

    Roughly 20% of all clinical pregnancies evolve into "spontaneous abortions". The causes of spontaneous abortion have been determined in under 60% of the total and comprise genetic, infectious, hormonal and immunological factors. In some cases the immune tolerance mechanism may be impaired and the foetus immunologically rejected (IMA, immunologically mediated abortion). The immunological mechanism implicated depends on the time in which pregnancy loss takes place. During preimplantation and up to the end of implantation (13th day) the cell-mediated immune mechanism (potential alloimmune etiologies) is responsible for early abortion. This mechanism involves immunocompetent decidual cells (eGL, endometrial granulated lymphocytes) already present during pre-decidualization (late luteal phase) and their production of soluble factors or cytokines. Once the implantation process is over, after blastocyst penetration of the stroma and the decidual reaction of uterine tissue, IMA could be caused by cell-mediated and humoral mechanism (anti-paternal cytotoxic antibodies or autoantibody etiology), by the production of paternal anti major histocompatibility complex antibodies, or even by an autoimmune disorder leading to the production of autoantibodies (antiphospholipid antibodies, antinuclear antibodies or polyclonal B cell activation). The diagnostic work-up adopted to select IMA patients is crucial and includes primary (karyotype of both partners, toxo-test, hysterosalpingography, endometrial biopsy, thyroid function tests, serum hprolactin, luteal phase dating) and secondary (full hemochromocytometric test, search for LE cells, lupus anticoagulant, anticardiolipin, antinuclear antibodies, Rheumatoid factor, blood complement VDRL) investigations. Therapeutical approaches vary. If autoimmune disorders are demonstrated therapies with different combinations of corticosteroids, aspirin and heparin or intravenous immunoglobulin are administered. Otherwise, therapy with paternal

  7. Cytogenetical analysis on 182 cases with the history of spontaneous abortion%182例有自然流产史夫妇的细胞遗传学研究

    张展; 马玉霞; 赵悦淑; 吴玥丽; 赵辉

    2011-01-01

    Objective: To analyze the incidence and relationship between abnormal karyotypes in spontaneous abortion. Methods: Chromosome analysis was performed on 182 cases with the history of spontaneous abortion. Results: Abnormal karotypes were detected in 21 cases ( 11.5% ), the percentages of large Y Chromosome and balanced translocations were equal (47.6%), balanced translocations including 8 cases of balanced reciprocal translocation and 1 cases of balanced Robertsonian translocations, 2 cases of chromosome polymorphism。 Conclusion: Chromosomal analysis should be carried out routinely in couples with unexplained failure of reproduction .%目的 分析自然流产夫妇的异常核型发生率,探讨自然流产与染色体核型异常之间的关系.方法 对182例反复流产夫妇行外周血染色体分析.结果 检出异常染色体核型21例,占受检夫妇的11.5%.异常核型中,大Y染色体、平衡易位者例数相等,占异常核型的47.6%,平衡易位者中相互易位8例,罗伯逊易位1例,染色体多态性2例.结论 对于不明原因的自然流产夫妇,染色体分析应作为常规的检测方法.

  8. 左甲状腺素干预后的甲状腺功能减退症对自然流产的影响%The influence of hypothyroidism on spontaneous abortion after treated with Ievothyroxine

    任美蓉; 张延丽

    2014-01-01

    Objective To study the effect of hypothyroidism be treated with levothyroxine on spontaneous abortion. Method In 30 rats suffered from hypothyroidism treated with levothyroxine,observe their pregnancy outcomes. With Methods Enzyme-linked immunosorbent assay (ELISA) was adopted to measure rats serum FT4、TSH、TPO-Ab levels,doing the vaginal smears,finding their estrous cycle, observe their pregnancy outcomes. Giving the rats which suffered from hypothyroidism levothyroxine therapy, observe their pregnancy outcomes,and with Methods ELISA was adopted to measure rats serum FT4、TSH、TPO-Ab levels. Results To compare the hypothyroidism abortion group and the hypothyroidism abortion be treated group,FT4 levels are lower,TSH levels are higher,TPO-Ab levels are higher, there were significant differences between two groups in these three assays (P0. 05);To compare offspring numbers of the hypothyroidism abortion be treated group and the normal control group,there was no significant difference in these three assays (P>0.05).Conclusion Hypothyroidism is one of the factors causing spontaneous abortion,can improve the pregnancy outcomes by levothyroxine treatment.%目的:探讨经过干预的甲状腺功能减退症对自然流产的影响。方法对30只患有甲状腺功能减退症的大鼠进行左甲状腺素干预,合笼后观察其妊娠结局。用酶联免疫吸附实验(ELISA法)测定大鼠血清中游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPO-Ab)水平,进行阴道涂片,观察其动情周期,合笼后观察其妊娠结局。结果甲减组与甲减治疗组相比FT4水平较低,TSH偏高,TPO-Ab偏高,均有显著性差异(P0.05);甲减治疗组与正常对照组仔鼠数量相比无显著性差异(P>0.05)。结论甲状腺功能减退症是导致自然流产的因素之一,可通过左甲状腺素治疗改善妊娠结局。

  9. 某石化企业育龄女工自然流产的病例对照研究%A case-control study of spontaneous abortion among female workers in a petrochemical enterprise

    李学庆; 唐怀青

    2012-01-01

    [Objective]To understand the factors influencing spontaneous abortion among female workers in petrochemical enterprises, and provide scientific evidence for developing control measures and reducing the spontaneous abortion prevalence. [Methods] Matched case-control study was adopted in the study. A respective survey was conducted on 156 female workers in a large petrochemical enterprise of Nanjing who had spontaneously abortion in recent 3 years by trained investigator. Fertile married women who had physical examination in the Center for Disease Control and Prevention matched for age with 1:1 ratio were selected as control group. The same questionnaire was adopted in both control group and case group. [ Results] The analysis of multiple logistic regression indicated that monthly income of family, menses, pets, work intensity, benzene and benzene homologues, heavy metal, seniority , noise and vibration had significant correlation with spontaneous abortion among female workers.. Monthly income of family was protection factor, but menses, pets, work intensity, benzene and benzene homologues, heavy metal, seniority, noise and vibration were risk factors (the OR were 1. 865, 4. 603, 1. 643, 11. 445, 4. 114, 4. 740, 3. 936, 2. 765, respectively). [Conclusion]This study had identified many kinds of factors correlated with spontaneous abortion among female workers. In order to improve the reproductive health and population quality of next generation, more health education of healthy childbearing should be improved and petrochemical enterprise female workers should leave job with occupational hazards exposure in the period of pregnancy.%目的 了解石化企业育龄女工自然流产发生的影响因素,为制定防制措施、减少自然流产的发生提供科学依据.方法 采用配对病例对照研究设计,由经培训的调查员选取南京市某大型石化生产企业3年期间发生的156例自然流产者进行回顾性问卷调查.对照组在市疾病

  10. Effects of miscarriage prevention with Chinese herbs for 60 recurrent spontaneous abortion patients%60例复发性流产患者中药安胎治疗的疗效观察

    刘新玉; 黄长盛; 罗颂平

    2013-01-01

    Objective It is to analyze the effects of miscarriage prevention with Chinese herbs for recurrent spontaneous a-bortion( RSA) patients, so as to provide reference for the necessity of treating USA with Chinese herbs. Methods 60 cases of patients were treated with miscarriage prevention of Chinese drugs according to the syndrome differentiation types. The number of cases with threaten abortion symptoms before and after treatment and the symptom improvement rate were calculated, the differentiation of serum β - HCG and P levels between the two stages were compared, and the effective ratio of miscarriage prevention treatment was counted. Results After miscarriage prevention treatment, the symptom improvement rate of bleeding, waist soreness, abdominal pain and anal bulg was 86% , 83% , 83% and 90% respectively, there was no significant difference in the improving rates of every symptom. The levels of serum β- HCG and P increased after treatment. The effective rati-o for patients had 2 times, 3 times and over 4 times spontaneous abortion history was 94% , 90% and 89% respectively, the differences were not significant. Conclusion Miscarriage prevention with Chinese herbs in the early pregnant stage can relieve the threaten abortion symptoms, elevate patients' serum β- HCG and P levels, so it can play the role of maintaining the pregnancy and preventing the probability of another miscarriage. It' s necessary to precede treatment with Chinese herbs in the early pregnant stage.%目的 分析有复发性流产病史患者再次妊娠后经中药安胎治疗的疗效,为中医药治疗复发性流产的必要性提供参考依据.方法 对60例有复发性流产史再次妊娠患者进行辨证分型,并随症加减给予中药安胎治疗.统计治疗前后先兆流产症状的例数及症状改善率;比较治疗前后β-HCG、P水平,计算安胎妊娠成功率.结果 安胎治疗后,患者阴道流血、腰酸、腹痛、肛门坠胀感症状改善率分别为86

  11. Human embryonal epithelial cells of the developing small intestinal crypts can express the Hodgkin-cell associated antigen Ki-1 (CD30 in spontaneous abortions during the first trimester of gestation

    Tsikouras Panagiotis

    2005-01-01

    Full Text Available Abstract Background Ki-1 (CD30 antigen expression is not found on peripheral blood cells but its expression can be induced in vitro on T and B lymphocytes by viruses and lectins. Expression of CD30 in normal tissues is very limited, being restricted mainly to a subpopulation of large lymphoid cells; in particular, cells of the recently described anaplastic large cell lymphoma (ALCL, the Reed-Sternberg (RS cells of Hodgkin's lymphoma and scattered large parafollicular cells in normal lymphoid tissues. More recent reports have described CD30 expression in non-hematopoietic and malignant cells such as cultured human macrophages, human decidual cells, histiocytic neoplastic cells, mesothelioma cells, embryonal carcinoma and seminoma cells. Results We investigated the immunohistochemical expression of CD30 antigen in 15 paraffin-embedded tissue samples representing small intestines from fetuses after spontaneous abortion in the 8th, 10th and 12th weeks using the monoclonal antibody Ki-1. Hormones had been administered to all our pregnant women to support gestation. In addition, a panel of monoclonal antibodies was used to identify leukocytes (CD45/LCA, B-lymphocytes (CD20/L-26 and T-lymphocytes (CD3. Our findings were correlated with those obtained simultaneously from intestinal tissue samples obtained from 15 fetuses after therapeutic or voluntary abortions. Conclusions The results showed that: (1 epithelial cells in the developing intestinal crypts express the CD30 (Ki-1 antigen; (2 CD30 expression in these epithelial cells is higher in cases of hormonal administration than in normal gestation. In the former cases (hormonal support of gestation a mild mononuclear intraepithelial infiltrate composed of CD3 (T-marker-positive cells accompanies the CD30-positive cells.

  12. C linical observation of allylestrenol drug treatment of recurrent spontaneous abortion during different periods%烯丙雌醇在不同时期用药治疗复发性自然流产的效果观察

    叶飞雪; 田玉华

    2014-01-01

    Objective To analyze the clinical efficacy of allylestrenol treatment of recurrent spontaneous abortion during differ -ent periods .Mte hods Clinal data of 172 patients with recurrent spontaneous abortion were analyzed and the patients were divided into control group ( n =43 ) and the observation group ( n =129 ) according to different dosages .The control group was given ogesterone treatment,and the observation group was divided into three subgroups ( n =43,each)according to different drug treatment periods and received allylestrenol treatment .The drug giving periods of subgroup A , B, and C were after ovulation ,two weeks after conception ,three weeks after conception respectively .Clinical efficacy and term delivery rates of each group were compared .Results The total effective rate of observation subgroup A was higher than that of subgroup C ( P <0.01)and term delivery rates of observation group were higher than that of control group( P <0.01),term delivery rate of observation subgroup A was higher than that of subgroup B ( P <0.05)and C( P <0.01).Conclusion The best periods of allylestrenol treatment of recurrent spontaneous abortion is after ovulation ,which can improve clinical treatment outcomes and the success rate of term delivery .%目的:分析烯丙雌醇在不同时期用药治疗复发性自然流产的临床效果。方法选择172例复发性自然流产患者为研究对象,根据用药不同分为两组。对照组43例给予黄体酮治疗,观察组129例给予烯丙雌醇治疗。观察组又根据用药时间不同分为3组,各43例。观察A组、观察B组及观察 C组用药时间分别为排卵后、受孕后2周及受孕后3周。比较各组治疗效果及足月分娩率。结果观察A组总有效率高于对照组和观察C组( P <0.01);观察组足月分娩率高于对照组( P<0.01),其中观察A组足月分娩率高于观察B组( P <0.05)和观察C组( P <0.01)。结论烯丙雌醇治

  13. Chromosome karyotype analysis of chorionic villi in 84 patients with early spontaneous abortion%84例自然流产绒毛细胞培养及染色体核型分析

    沈素岩; 张金艳

    2016-01-01

    目的:探讨自然流产患者绒毛细胞培养及染色体核型分析的重要性及临床意义,为下次妊娠做出指导。方法:对84例患者在无菌条件下取绒毛组织,进行细胞培养及染色体核型分析。结果:实施染色体核型分析的患者84例,女胎明显多于男胎,有统计学意义;异常核型43例,正常核型41例,二者男女性别比例无统计学意义;异常核型以染色体数目异常为主(83.72%),以三体最常见(58.33%)。结论:绒毛细胞培养染色体核型分析具有临床意义,对下次妊娠指导起了重要作用,为优生工作的开展提供了重要指标。%Objective:To investigate the importance and clinical significance of chromosome karyotype analysis from chorionic villi in patients with spontaneous abortion, and to provide guidance for the next pregnancy.Methods:chorionic villi cultivation and chromosome karyotype analysis were done from 84 cases of spontaneous abortion.Results:Among 84 cases of fetus, the female fetal were significantly more than male fetal, with statistical significance.43 cases of abnormal karyotype and 41 cases with normal karyotype were checked out. The ratio of sex had no statistical significance;Numerical abnormality was the majar part of chromosome abnormality (83.72%),and the most common cases were autosomal trisomies (58.33%).Conclusion: Chromosome karyotype analysis from chorionic villi has clinical significance.And it had important function for the next pregnancy guidance.It could provide the important index for the development of the eugenic work.

  14. Etiology of Early Recurrent Spontaneous Abortion in Women with Advanced Maternal Age%高龄早期复发性流产患者流产原因分析

    刘玉昆; 陈欣; 刘颖琳; 陈慧; 谭剑平; 张建平

    2013-01-01

    [Objective] To investigate the etiology of early recurrent spontaneous abortion (RSA) in patients with advanced maternal age.[Methods] From January 2008 to October 2012,the data of 82 early RSA patients with advanced maternal age who underwent both conventional examination for RSA and karyotype analysis on products of conception were retrospectively analyzed.The rate of abnormal embryonic karyotype in patients with RSA was compared to that with sporadic spontaneous abortion (SSA).The distribution of causes in primary and secondary RSA was also compared.The distribution of causes of RSA among woman with different number of prior spontaneous abortion were compared.[Results] The rate of abnormal embryonic karyotype in patients with SSA was higher than that of patients with RSA (85.1% vs 67.1%).Embryonic karyotype anomaly was the most frequent (67.1%) causes of RSA.The prevalence of endocrinologic factor,uterine anomaly,APA positive,parental chromosomal abnormality and infection were 24.4%,19.5%,12.2%,3.7%,and 2.4%,respectively.The prevalence of RSA of truly unexplained causes was 15.9%.The distribution of causes of early RSA in primary and secondary RSA had no difference.The distribution of causes did not differ among patients with different spontaneous abortion numbers.[Conclusions] Abnormal embryonic karyotype was the most common cause of RSA in patients with advanced maternal age.Embryonic karyotype analysis should be added to the list of evaluation items in women with RSA.%[目的]探讨高龄早期复发性流产患者的流产原因.[方法]回顾性分析2008年1月至2012年10月,在我院诊治的高龄早期复发性流产患者的病历资料,对已行系统病因学检查,并且流产后成功行绒毛染色体分析的82例患者的病因分布进行分析.并比较了高龄早期复发性流产与高龄偶发性早期流产的绒毛染色体异常发生率,原发性流产与继发性流产的病因分布,不同流产次数的复发

  15. Conceptualising abortion stigma

    A. Kumar; L. Hessini; E.M.H. Mitchell

    2009-01-01

    Abortion stigma is widely acknowledged in many countries, but poorly theorised. Although media accounts often evoke abortion stigma as a universal social fact, we suggest that the social production of abortion stigma is profoundly local. Abortion stigma is neither natural nor 'essential' and relies

  16. Space Shuttle ascent aborts

    Schmidgall, Richard A.

    1989-09-01

    Specific guidance functions and trajectory design of return to launch site (RTLS) and transoceanic abort landing (TAL) intact abort profiles, as well as the increasing emphasis on contingency aborts, are presented. Various systems failures including Space Shuttle main engine failures and detailed technical analyses, including the design of powered flight abort trajectories, are considered. The most critical of flight abort situations is the RTLS, while TAL is the preferred abort when uphill capability is no longer available. It is concluded that one principle must remain to ensure continuing success of Space Shuttle flights: namely that intact and contingency aborts necessitate development to ensure safe return of the vehicle, payload, and crew whenever possible.

  17. Should abortion be legalized?

    Sodhy, L S

    1968-01-01

    Abortion is an important means of family planning, especially when contraception is unavailable or when it fails. Morbidity associated with legal abortion is low, though illegal abortion is a common cause of maternal mortality. The Union of Soviet Socialist Republic, Hungary, Yugoslavia, Czechoslovakia, Romania, Poland, and the German Demogratic Republic all have laws legalizing abortion. Legalized abortion is the surest method of population control and should be promoted if the moral and religious objections can be overcome. PMID:12255647

  18. Detection and significance of interleukins level changes in peripheral blood of rec rent spontaneous abortion%反复自然流产患者外周血白介素水平变化检测的意义

    王振荣; 刘娜; 杜潘艳; 赵国静; 何亚萍; 王丽荣

    2013-01-01

    目的:探讨相关白细胞介素在反复自然流产患者体内免疫调节机制的表达及作用.方法:用酶联免疫吸附试验检测120例反复自然流产患者体内的白介素水平.结果:反复自然流产患者(研究组)外周血血清中白介素水平与正常早孕妊娠组(研究组)比较,IL-2、IL-8的含量研究组高于对照组,而IL-4、IL-6、IL-10的含量则相反,两组差异有统计学意义(P<0.05).结论:孕妇外周血中白介素水平失衡变化可引起反复自然流产的发生.%Objective: To investigate the expression and role of interleukins in patients with recurrent spontaneous abortion (RSA) .Methods: Serum interleukins were measured by enzyme -linked immunosorbant assay (ELISA) in 120 RSA patients, which were randomly divided into early RSA and normal early pregnancy groups.Results: The serum IL - 2, IL - 8 in RSA group were obviously higher than those of normal control group.IL - 4, IL - 6, IL - 10 in RSA group were obviously lower than those of normal control group.Conclusion: The imbalance changes of interleukins in pregnant women would cause RSA.

  19. Expression of PAF-R and VEGF in patients with early spontaneous abortion%早期自然流产患者PAF-R及VEGF表达水平的研究

    徐俊; 冯春宇; 周俊; 郑坚; 林子; 周伟新

    2012-01-01

    目的:探讨早期自然流产患者蜕膜绒毛组织中血小板活化因子受体(PAF-R)与血管内皮生长因子(VEGF)的表达水平.方法:将2008年1月至2009年12月期间在广东省深圳市龙岗区第二人民医院妇产科收治的60例患者分为3组:稽留流产组(Ⅰ组)、先兆流产(Ⅱ组)、正常早孕组(Ⅲ组),每组各20例.采用积分光度法及免疫组织化学法对3组患者蜕膜绒毛组织中PAF-R、VEGF的表达情况进行分析.结果:(1) PAF-R、VEGF在3组患者蜕膜绒毛组织中的表达均呈阳性.(2)PAF-R、VEGF表达水平:Ⅰ组<Ⅱ组<Ⅲ组(均P<0.05).结论:PAF-R、VEGF表达降低普遍存在于早期自然流产患者中,PAFR、VEGF表达的降低可能是导致早期自然流产的重要因素.%Objective:To determine the expression of platelet activating factor receptor ( PAF-R) and vascular endothelial growth factor ( VEGF) in decidual and villous tissues from patients with early spontaneous abortion. Methods; Sixty women registered to the Department of

  20. Step methods of combination of Chinese traditional and Western medicine of recurrent spontaneous abortion treatment%中西医结合法分步治疗复发性流产临床应用

    田晓霏; 赵志梅; 夏天; 窦真

    2016-01-01

    随着复发性流产发病率增高、病因复杂,其临床治疗方法愈加被关注.介绍中西医结合法治疗复发性流产的临床诊疗步骤,主要内容包括明确诊断、查明病因、改善体质、监卵助孕、孕后保胎和调整精神因素几大方面,并隅举病案加以说明.其中改善体质为重要环节,医生在指导患者规范日常生活习惯的基础上,根据中医辨证分型运用中药、针灸治疗,四诊合参、综合调理;孕后保胎为关键步骤,反复堕胎,胎元不固,需持续治疗,胎元方可健.%With the increase in the incidence of recurrent miscarriage, complex etiology, clinical treatments even more to be concerned about. This article describes the clinical diagnosis and treatment pathways of curing the recurrent miscarriage with the integrative medicines step by step, including diagnosis, identify the causes and adjust physique, follicle monitoring, pregnant after miscarriage and adjust spirit,and combined with a case. In these aspects, adjusting physique is the key link. On the basis of guiding patients to establish their daily living habits, doctors are willing to treat comprehensively with traditional Chinese medicine theories. How to keep pregnant is the important part, because of repeated spontaneous abortions may take the insecurity of the fetal origin, continuous treatment can protect the fetus.

  1. CD107a Expression and IFN-γ Production as Markers for Evaluation of Cytotoxic CD3+ CD8+ T Cell Response to CMV Antigen in Women with Recurrent Spontaneous Abortion

    Batoul Tarokhian

    2014-01-01

    Full Text Available Background: Some evidence has shown a relationship between primary human cytomegalovirus (CMV infection and pregnancy loss. The impact of CMV infection reactivation during pregnancy on adverse pregnancy outcomes is not completely understood. It is proposed that altered immune response, and therefore, recurrence or reactivation of latent CMV infection may relate to recurrent spontaneous abortion (RSA; however, few data are available in this regard. To find out about any cell mediated defect and reactivation of latent CMV infection in women with RPL, cellular immunity to the virus has been evaluated by specific cytotoxic T lymphocyte (CTL response to CMV. Materials and Methods: In a case control study, CTL CD107a expression and intercellular IFN-γ production in response to CMV pp65 antigen and staphylococcus enterotoxin B (SEB in women with RSA were assessed by flow cytometric analysis. Forty-four cases with history of recurrent pregnancy and forty-four controls with history of successful pregnancies were included. The FACSCaliber flow cytometer were used for analysis. Results: No significant difference was observed between CD107a expression and IFN-γ production in response to CMV PP65 antigen in RPL patients and control group. However, the cytotoxic response to SEB antigen in patients with RPL was significantly lower than control group (p=0.042. Conclusion: The results of this study show that impaired CD107a expression and IFN-γ production as CTL response to CMV does not appear to be a major contributing and immune incompetence factor in patients with RPL, but cytotoxic T cell response defect to other antigens requires to be assessed further in these patients.

  2. Abortion Before & After Roe

    Joyce, Ted; Tan, Ruoding; Zhang, Yuxiu

    2013-01-01

    We use unique data on abortions performed in New York State from 1971–1975 to demonstrate that women travelled hundreds of miles for a legal abortion before Roe. A100- mile increase in distance for women who live approximately 183 miles from New York was associated with a decline in abortion rates of 12.2 percent whereas the same change for women who lived 830 miles from New York lowered abortion rates by 3.3 percent. The abortion rates of nonwhites were more sensitive to distance than those of whites. We found a positive and robust association between distance to the nearest abortion provider and teen birth rates but less consistent estimates for other ages. Our results suggest that even if some states lost all abortion providers due to legislative policies, the impact on population measures of birth and abortion rates would be small as most women would travel to states with abortion services. PMID:23811233

  3. Abortion and psychiatric practice.

    Stotland, Nada L

    2003-03-01

    The subject of abortion is fraught with politics, emotions, and misinformation. A widespread practice reaching far back in history, abortion is again in the news. Psychiatry sits at the intersection of the religious, ethical, psychological, sociological, medical, and legal facets of the abortion issue. Although the religions that forbid abortion are more prominent in the media, many religions have more liberal approaches. While the basic right to abortion has been upheld by the U.S. Supreme Court, several limitations have been permitted, including parental notification or consent (with the possibility of judicial bypass) for minors, waiting periods, and mandatory provision of certain, sometimes biased, information. Before the Roe v. Wade decision legalizing abortion in 1973, many women were maimed or killed by illegal abortions, and psychiatrists were sometimes asked to certify that abortions were justified on psychiatric grounds. Currently, there are active attempts to convince the public and women considering abortion that abortion frequently has negative psychiatric consequences. This assertion is not borne out by the literature: the vast majority of women tolerate abortion without psychiatric sequelae. The psychiatric outcome of abortion is best when patients are able to make autonomous, supported decisions. Psychiatrists need to know the medical and psychiatric facts about abortion. Psychiatrists can then help patients prevent unwanted pregnancies, make informed decisions consonant with their own values and circumstances when they become pregnant, and find appropriate social and medical resources whatever their decisions may be. PMID:15985924

  4. 早期自然流产患者蜕膜组织中ICAM-1/Mac-1的表达%Expression of ICAM-1 and Mac-1 in decidual tissues of patients with early spontaneous abortion

    王立芹; 于学文; 张永爱; 周小兰; 褚静; 李静

    2012-01-01

    目的 通过观察细胞间黏附分子-1(ICAM-1)和巨噬细胞分化抗原-1(Mac-1)在早期自然流产患者蜕膜组织中的表达,探讨ICAM-1/Mac-1与早期自然流产的关系.方法 采用免疫组化方法检测早期自然流产患者35例和同期妊娠的30例健康妇女蜕膜组织中ICAM-1、Mac-1的表达,用激光共聚焦显微镜(CLSM)双标检测二者关系并加以分析.结果 早期自然流产患者蜕膜组织基质细胞ICAM-1、Mac-1蛋白表达强度高于对照组(Z=-3.056,P=0.002;Z=-2.132,P=0.033);流产组蜕膜腺体细胞ICAM-1、Mac-1蛋白表达强度略低于对照组(Z=-1.978,P=0.048;Z=-1.973,P=0.048);共聚焦显微镜下ICAM-1和Mac-1在早期自然流产组和对照组的蜕膜组织均有部分重叠表达.结论 ICAM-1和Mac-1在早期自然流产患者蜕膜组织基质细胞的高表达和腺体细胞的低表达可能与早期自然流产的发生有关.%Objective To explore the relationship between intracellular adhesion molecule-l( ICAM-1 )/macrophage differentiation antigen-l( Mac-1 ) and early spontaneous abortion ( SA ) by detecting the expression of ICAM-1 and Mac-1 in decidual tissues of patients with early SA. Methods The expression of ICAM-1 and Mac-1 in the deciduous tissues of 35 women with early SA and of 30 with normal abortion was detected by S-P immunohistochemistry. The relationship between ICAM-l/Mac-1 and SA was analyzed with confocal scanning laser microscope ( CLSM ). Results The expressive intensity of ICAM-1 and Mac-1 was significantly stronger in the decidual stromal cells in SA group than that in control group ( Z = -3.056, P = 0. 002; Z = -2. 132, P = 0.033 ), but the protein expressive intensity of ICAM-1 and Mac-1 in decidual glandular epithelial cells in SA group was slightly lower than that in control group ( Z = - 1. 978, P = 0. 048; Z = - 1. 973 , P =0. 048 ). The ICAM-1 and Mac-1 expression in the deciduous tissues overlapped under CLSM in both groups. Conclusion The high expression

  5. 淋巴细胞注射治疗复发性流产且封闭抗体为阴性的50例患者的临床分析%Clinical analysis of lymphocyte injection treatment for 50 recurrent spontaneous abortion patients with negative blocking antibody

    徐珊珊

    2015-01-01

    Objective To explore the influence of lymphocyte injection treatment on recurrent spontaneous abortion patients with negative blocking antibody. Methods A total of 50 diagnosed recurrent spontaneous abortion patients due to lack of blocking recurrent were randomly divided into observation group with 25 cases (lymphocyte injection treatment) and control group with 25 cases (symptomatic treatment by integrated traditional Chinese and Western medicines). Treatment conditions were compared between the two groups. Results There were statistically significant differences of gestation situation, positive rate of blocking antibody, and quality of gestational blocking antibody after immunization between the two groups (P<0.05). Conclusion The effect of lymphocyte injection treatment is precise for treating recurrent spontaneous abortion patients with negative blocking antibody, and this method can reduce degree of risk.%目的:探讨淋巴细胞注射治疗对于复发性流产且封闭抗体为阴性的患者的影响。方法确诊为因缺乏封闭抗体而引发的复发性流产的患者50例,随机分成观察组25例(淋巴细胞注射治疗)和对照组25例(中西医结合对症治疗),对比两组患者的治疗情况。结果两组患者在妊娠情况、产生封闭抗体的阳性率、免疫后妊娠的封闭抗体的性质方面相比差异具有统计学意义(P<0.05)。结论淋巴细胞注射治疗复发性流产且封闭抗体呈阴性的患者效果明显,风险程度降低。

  6. Abortion - surgical - aftercare

    ... this page: //medlineplus.gov/ency/patientinstructions/000658.htm Abortion - surgical - aftercare To use the sharing features on ... please enable JavaScript. You have had a surgical abortion. This is a procedure that ends pregnancy by ...

  7. Legalized abortion in Czechoslovakia.

    Zidovsky, J; Zwinger, A

    1972-01-01

    A law legalizing abortion was passed nearly 20 years ago in Czechosl ovakia. The law aimed to give women the freedom to decide for themselves whether they want to be pregnant and to decrease the dangers of illegal abortion. The law resulted in a decreased number of abortions and of complications and deaths associated with abortion. Fertility in the country also declined. In 1968 there were more abortions than live births in the country. Since 1957, the law has been modified. The law still aims to prevent the birth of defective children and to protect the life and health of mothers. Each application for abortion is now examined on its own merits. Favorable economic circumstances, prolife social policies adopted by the government, and the new stricter interpretation of the abortion law have resulted in a r ising birthrate since 1969. Contraception is still stressed as preferab le to abortion. PMID:12256872

  8. Physician provision of abortion before Roe v. Wade.

    Joffe, C

    1991-01-01

    With the possibility of the Supreme Court overturning the landmark Roe v. Wade (1973) case legalizing abortion, a review of abortion practices pre-Roe is instructive. Abortion became criminalized in the US around 1870, yet many abortions were performed. While estimates for the yearly number of pre-Roe illegal abortions roughly resemble today's number of legal abortions, the difference between legal and illegal abortion rests in the difference between the large number of women who died or were injured then, and the very few women who now die from illegal abortions. Along with the self-induced abortion, different categories of providers performed illegal abortions: physicians, nonphysicians, nurses, midwives, and lay people; all with varying skill, experience, and motives. While there were "butchers" and sexual exploiters, there were also competent, beloved physicians. There were the financially motivated physicians providing abortions full time, and the occasional providers acting with a sense of conscience, risking successful practices and jail. Within this "conscience" group of 44 interviewees gathered through personal networks, ads, etc., abortions were: performed outside of hospitals, reducing the risk of discovery, but creating greater medical risks; begun outside of a hospital with the intrusion into the uterus of an object, provoking a "spontaneous abortion" (miscarriage) needing completion by D and C (dilation and curettage) within a hospital, but only a limited number of such patients could be referred before arousing suspicion; and in a hospital under disguised circumstances, a very tricky undertaking with severe limitations, available only a few times before risking detection. Avoidance and lack of training by today's physicians and the well organized antiabortion groups will undoubtedly make illegal abortions even more difficult to engage in than the pre-Roe days. PMID:12317573

  9. Correlation study of the expression of VEGF and PAF-R in the decidua and villus of patients with early spontaneous abortion%蜕膜与绒毛组织中血管内皮生长因子及血小板活化因子受体的表达与早期自然流产相关性

    徐俊; 冯春宇; 周俊; 郑坚; 何兰; 林子; 周伟新

    2011-01-01

    Objective To investigate the expression levels of vascular endothelial growth factor (VEGF) and platelet activate factor receptor (PAF-R) in the decidua and villus of patients with normal early pregnancy and early spontaneous abortion, and to study the correlation between the expression of VEGF/PAF-R and early spontaneous abortion. Methods 60 patients admitted in the department of obstetrics and gynaecology in our hospital from January 2008 to December 2009 were assigned into three groups: group A (20 cases of induced abortion), group B (20 cases of threatened abortion) and group C (20 cases of missed abortion). Immunohistochcmical techniques were used to investigate the expression levels of VEGF, PAF-R of histological in the three groups. Results Expressions of VEGF, PAF-R were found positive in decidua and villus tissue in all the three groups. The level of VEGF in group A is the highest, then follows group B and group C (P<0.05). The levels of PAF-R is highest in group A, and lowest in group C (P<0.05). Conclusion The expression level of VEGF and PAF-R were relatively low in patients with early spontaneous abortion, which might be an important factor that leads to early spontaneous abortion.%目的 研究血管内皮生长因子(VEGF)与血小板活化因子受体(PAF-R)在正常早期妊娠及早期自然流产患者蜕膜及绒毛组织中的表达,探讨其与早期自然流产的相关性.方法选取2008年1月至2009年12月在我院妇产科就诊的60例患者作为研究对象,分为正常早孕人流组(A组)、先兆流产组(B组)、稽留流产组(C组)各20例;采用免疫组化技术对VEGF、PAF-R在三组蜕膜及绒毛组织中的表达进行组织学检查及定量分析.结果(1)三组蜕膜及绒毛组织中VEGF、PAF-R均有阳性表达.(2) VEGF表达量:A组>B组>C组(P<0.05).(3)PAF-R表达量:A组>B组>C组(P<0.05).结论早期自然流产患者存在VEGF、PAF-R表达水平的降低,VEGF、PAF-R表达水平的改变可能

  10. Late-term abortion.

    Epner, J E; Jonas, H S; Seckinger, D L

    1998-08-26

    Recent proposed federal legislation banning certain abortion procedures, particularly intact dilatation and extraction, would modify the US Criminal Code such that physicians performing these procedures would be liable for monetary and statutory damages. Clarification of medical procedures is important because some of the procedures used to induce abortion prior to viability are identical or similar to postviability procedures. This article reviews the scientific and medical information on late-term abortion and late-term abortion techniques and includes data on the prevalence of late-term abortion, abortion-related mortality and morbidity rates, and legal issues regarding fetal viability and the balance of maternal and fetal interests. According to enacted American Medical Association (AMA) policy, the use of appropriate medical terminology is critical in defining late-term abortion procedures, particularly intact dilatation and extraction, which is a variant of but distinct from dilatation and evacuation. The AMA recommends that the intact dilatation and extraction procedure not be used unless alternative procedures pose materially greater risk to the woman and that abortions not be performed in the third trimester except in cases of serious fetal anomalies incompatible with life. Major medical societies are urged to collaborate on clinical guidelines on late-term abortion techniques and circumstances that conform to standards of good medical practice. More research on the advantages and disadvantages of specific abortion procedures would help physicians make informed choices about specific abortion procedures. Expanded ongoing data surveillance systems estimating the prevalence of abortion are also needed. PMID:9728645

  11. Abortion among Adolescents.

    Adler, Nancy E.; Ozer, Emily J.; Tschann, Jeanne

    2003-01-01

    Reviews the current status of abortion laws pertaining to adolescents worldwide, examining questions raised by parental consent laws in the United States and by the relevant psychological research (risk of harm from abortion, informed consent, consequences of parental involvement in the abortion decision, and current debate). Discusses issues…

  12. Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1 isolated from a vaginal swab of a woman with spontaneous abortion

    Gartemann Karl-Heinz

    2010-02-01

    Full Text Available Abstract Background Corynebacterium aurimucosum is a slightly yellowish, non-lipophilic, facultative anaerobic member of the genus Corynebacterium and predominantly isolated from human clinical specimens. Unusual black-pigmented variants of C. aurimucosum (originally named as C. nigricans continue to be recovered from the female urogenital tract and they are associated with complications during pregnancy. C. aurimucosum ATCC 700975 (C. nigricans CN-1 was originally isolated from a vaginal swab of a 34-year-old woman who experienced a spontaneous abortion during month six of pregnancy. For a better understanding of the physiology and lifestyle of this potential urogenital pathogen, the complete genome sequence of C. aurimucosum ATCC 700975 was determined. Results Sequencing and assembly of the C. aurimucosum ATCC 700975 genome yielded a circular chromosome of 2,790,189 bp in size and the 29,037-bp plasmid pET44827. Specific gene sets associated with the central metabolism of C. aurimucosum apparently provide enhanced metabolic flexibility and adaptability in aerobic, anaerobic and low-pH environments, including gene clusters for the uptake and degradation of aromatic amines, L-histidine and L-tartrate as well as a gene region for the formation of selenocysteine and its incorporation into formate dehydrogenase. Plasmid pET44827 codes for a non-ribosomal peptide synthetase that plays the pivotal role in the synthesis of the characteristic black pigment of C. aurimucosum ATCC 700975. Conclusions The data obtained by the genome project suggest that C. aurimucosum could be both a resident of the human gut and possibly a pathogen in the female genital tract causing complications during pregnancy. Since hitherto all black-pigmented C. aurimucosum strains have been recovered from female genital source, biosynthesis of the pigment is apparently required for colonization by protecting the bacterial cells against the high hydrogen peroxide concentration in

  13. Spontaneous abortion and physical strain around implantation

    Hjøllund, Niels Henrik Ingvar; Jensen, T.K.; Bonde, J.P.;

    2000-01-01

    time periods are the relevant measure. We followed a cohort of first pregnancy planners from termination of birth control until pregnancy for a maximum of six menstrual cycles. The analyses include 181 pregnancies, of which 32 were subclinical pregnancies detected by hCG analysis only. During early...

  14. Spontaneous Pregnancy Loss in Denmark Following Economic Downturns.

    Bruckner, Tim A; Mortensen, Laust H; Catalano, Ralph A

    2016-04-15

    An estimated 11%-20% of clinically recognized pregnancies result in spontaneous abortion. The literature finds elevated risk of spontaneous abortion among women who report adverse financial life events. This work suggests that, at the population level, national economic decline-an ambient and plausibly unexpected stressor-will precede an increase in spontaneous abortion. We tested this hypothesis using high-quality information on pregnancy and spontaneous loss for all women in Denmark. We applied time-series methods to monthly counts of clinically detected spontaneous abortions (n = 157,449) and the unemployment rate in Denmark beginning in January 1995 and ending in December 2009. Our statistical methods controlled for temporal patterns in spontaneous abortion (e.g., seasonality, trend) and changes in the population of pregnancies at risk of loss. Unexpected increases in the unemployment rate preceded by 1 month a rise in the number of spontaneous abortions (β = 33.19 losses/month, 95% confidence interval: 8.71, 57.67). An attendant analysis that used consumption of durable household goods as an indicator of financial insecurity supported the inference from our main test. Changes over time in elective abortions and in the cohort composition of high-risk pregnancies did not account for results. It appears that in Denmark, ambient stressors as common as increasing unemployment may precede a population-level increase in spontaneous abortion. PMID:27009344

  15. Abortion in Ireland.

    Francome, C

    1992-08-22

    Substantial legal barriers to abortion persist in both the Irish Republic and Northern Ireland, despite growing popular support for abortion under certain conditions. A 1983 amendment to the republic's constitution guarantees the fetus the same right to life s the mother and bans the provision of information on abortion. Although a recent well publicized case of a pregnant, suicidal 14-year-old who travelled to England for an abortion resulted in an Irish Supreme Court ruling that abortion was acceptable in cases of "real and substantial risk" to a woman's life, uncertainty still surrounds the right to travel to England for the procedure. In Northern Ireland, the 1967 Abortion Act does not apply and abortions are denied even in cases of rape and incest. A total of 1766 women from Northern Ireland and 4158 from the republic travelled to England for abortions in 1991. Public opinion seems to have shifted toward support for less restrictive abortion laws, however. Whereas 80% of those surveyed in a 1980 Irish poll supported to ban on abortion in all cases, this statistic had dropped to 30% by 1990. Similarly, a 1991 poll taken in Northern Ireland found 80% of respondents to be a favor of abortion in cases where the procedure is necessary to maintain a woman's physical or mental health. PMID:1392954

  16. 30例体外受精-胚胎移植后流产绒毛原代培养及染色体核型分析%Primary culture of villi in 30 cases of spontaneous abortion after in vitro fertilization -embryo transfer and analysis on chromosomal karyotype

    何国平; 刘雨生; 童先宏; 周桂香; 宋雅娴; 骆丽华; 陈玲; 胡美虹

    2011-01-01

    目的:分析30例体外受精-胚胎移植(IVF-ET)流产胚胎绒毛染色体核型组成,探讨流产原因.方法:收集30例IVF-ET流产胚胎绒毛,行体外原代培养、染色体制备及核型分析.观察既往不同流产次数对胚胎绒毛染色体异常率的影响;按流产胚胎性别,分析性别差异与染色体异常率间的关系.结果:30例IVF-ET流产胚胎绒毛体外培养成功30例,成功率100%.30例标本中染色体异常核趔20例,占66.70%,其中三体核型14例,21单体型1例,多倍体1例,嵌合体2例,其他异常核型2例.单次流产史患者13例,胚胎异常核型9例(69.23%);反复流产(≥2次)史患者17例,胚胎异常核型11例(64.71%),两组间比较无显著性差异.14例男胎中异常核型10例,占71.42%;15例女胎中异常核型9例,占60.00%,两组比较差异有统计学意义(P<0.05).结论:胚胎染色体异常是IVF-ET早期自然流产的主要原因,绒毛染色体检查对寻找IVF-ET失败原因具有重要的指导意义.%Objective: To analyze the composition of chromosomal karyotype of villi in 30 cases of spontaneous abortion after in vitro fertilization- embryo transfer (IVF -ET), explore the causes of abortion. Methods: The villus tissues of 30 cases of spontaneous abortion after IVF - ET were collected, then primary culture in vitro, chromosomal preparation and karyotype analysis were performed; the effect of abortion times on incidence of chromosomal abnormality in villi was observed; the relationship between gender difference and incidence of chromosomal abnormality was analyzed according to embryo sex. Results: The success rate of primary culture of villi in vitro was 100%; 20 cases were found with abnormal chromosomal karyotype, accounting for 66. 70%, including 14 cases of trisome karyotype, 1 case of 21 monosome karyotype, 1 case of polyploidy karyotype, 2 cases of chimera karyotype and 2 cases of other abnormal karyotype; 13 cases had the history of abortion once, 9 cases were

  17. HLA-G基因14bp插入/缺失多态性与不明原因复发性流产患者相关性的病例对照研究%Association between HLA-G 14-bp Insertion/Deletion Polymorphism and Women with Recurrent Spontaneous Abortions

    张惠湘; 朱永生

    2012-01-01

    目的 探讨HLA-G基因3'非翻译区14bp插入/缺失多态性与不明原因复发性流产患者的相关性.方法 选择343名不明原因复发性流产患者,按照不同流产次数分为流产2次组(n=152),流产3次组(n=132),流产4次及以上组(n=59);268名正常妊娠妇女作为健康对照组.采用聚合酶链反应(PCR)及8%非变性聚丙烯酰胺凝胶电泳分离技术检测HLA-G基因14bp插入/缺失多态性位点在不明原因复发性流产患者及正常妊娠组中的基因型频率分布.结果 HLA-G基因14bp插入/缺失多态性位点的基因型频率分布在流产4次及以上组与正常妊娠组差异有统计学意义(χ2=6.941,P=0.031),流产4次及以上组+14bp等位基因频率分布显著高于正常妊娠组(χ2=4.956,P=0.026,OR=1.573,95%CI:1.054~2.349).结论 H LA-G 14 bp 缺失多态性在维持正常的妊娠中可能有重要作用.%Objective To investigate the association between HLA - G gene 14 - bp insertion/deletion polymorphism in 3 UTR and recurrent spontaneous abortions. Methods In this study, a total of 611 Chinese women were genotyped for the + 14 - bp/14 - bp polymorphism, including 343 who had recurrent spontaneous abortions (two miscarriages; 152, three miscarriages; 132, four or more miscarriages; 59) , 268 women with normal fertility as controls. Results To our knowledge, this is the first report that Significant difference was observed in the distribution of + 14 - bp/ + 14 - bp genotype between controls and the recurrent abortion group with four or more abortions ( X2 = 6. 941, P - 0. 031 ) . The + 14 - bp homozygote sequence was more prominent among those with recurrent spontaneous abortions (four or more recurrent miscarriages) in contrast to fertile control women (X2 = 4.956, P=0.026, OR =1.573, 95%CI: 1.054 ~2. 349). Conclusion A 14 - bp insertion/deletion polymorphism in exon 8 has a possible role in HLA ?G expression in certain cases of recurrent spontaneous abortions. However, additional

  18. Expression of Ki-67, Bcl-2 and Bax in the First Trimester Abortion Materials

    Ender DÜZCAN

    2010-01-01

    Full Text Available Objective: The aim of this study was to investigate possible similar or different mechanisms in recurrent and spontaneous abortion by evaluating immunohistochemical correlation between proliferation marker Ki-67, and apoptosis markers Bcl-2 and Bax in the fetal trophoblasts and maternal deciduas from abortion material.Material and Method: Eighty samples of curettage materials from 65 abortion patients histopathologically diagnosed “decidua showing Arias-Stella reaction and chorionic villi” or only “decidua showing Arias-Stella reaction” were included in the study. Hematoxylin&Eosin stained sections from all cases were re-evaluated and further stained immunohistochemically using antibodies against Ki-67, Bcl-2 and Bax.Results: Proliferation rate evaluated by Ki-67 expression both in the cytotrophoblastic cells and decidua was found to be significantly lower in spontaneous and recurrent abortions compared to evacuation abortion. The extent of Bcl-2 expression in syncytiotrophoblastic cells covering villous stroma was also decreased in spontaneous abortion. There were no significant differences between spontaneous and recurrent abortions in terms of Bcl-2 expression in syncytiotrophoblasts and Ki-67 proliferation index in cytotrophoblastic cells or decidua. Bax staining showed minimal decidual expression in a few spontaneous and recurrent abortions.Conclusion: We concluded that proliferation rate was decreased in fetal villous cytotrophoblasts and maternal deciduas in spontaneous and recurrent abortions. We also proposed that loss of Bcl-2 expression in syncytiotrophoblasts may cause abortion in a subset of cases. However, the data from spontaneous and recurrent abortions did not not support the presence of different mechanisms in both groups.

  19. The study of relationship between the quantity of soluble forms of human leukocyte antigen - G ( sHLA - G ), tumor necrosis factor- α and recurrent spontaneous abortion%血清TNF-α及sHLA-G水平与习惯性流产的关联性分析

    刘学云; 王霞

    2012-01-01

    Objective: To determine the levels of Soluble Forms of Human Leukocyte Antigen -G (sHLA-G), Tumor Necrosis Factor - a in human serum of patients with recurrent spontaneous abortion to explore relationship between sHLA - G and TNF - α and recurrent spontaneous abortion. Methods; A hundred women in early pregnancy were selected and divided into two groups; 58 in the RSA group and 42 in the control group who had at least one live birth without history of spontaneous abortion. The level of sHLA - G and TNF - α were detected by Enzyme - Linked Immuno Sorbent Assay. Results; The levels of Soluble Forms of Human Leukocyte Antigen-G (sHLA -G) in human serum of patients with recurrent spontaneous abortion were significantly decreased than those of normal early pregnant women. It had a significant difference (P < 0.05) , while the levels of Tumor Necrosis Factor - α by peripheral blood mononuclear cells were significantly higher. It reached a significant difference (P < 0.05). Conclusion; Both levels of sHLA -G and TNF - α are correlated with the results of pregnancy. The lack of sHLA - G and the excess of TNF - α in human serum may lead to the recurrent spontaneous abortion.%目的 通过定量方法研究测定习惯性流产(RSA)患者血清中的肿瘤坏死因子-α(TNF-α)及可溶性人白细胞抗原G(sHLA - G)的水平,探讨TNF -α及sHLA-G与习惯性流产有无相关性.方法 选择早期妊娠孕妇100例,正常对照组:无自然流产史早期妊娠健康孕妇42例,RSA组:有习惯性流产史二次及二次以上的早期妊娠妇女58例,采用酶联免疫(ELISA)法定量检测两组样本血清中TNF-α及sHLA-G的水平.结果 RSA组血清中外周血淋巴细胞的TNF-α表达水平则明显高于正常妊娠组差异有显著性(p<0.05),而sHLA -G的表达水平明显低于正常对照组,差异有显著性(P<0.05).结论 妊娠早期孕妇血清中TNF-α及sHLA-G与妊娠成功有直接关系,TNF-α升高及sHLA-G降低可能会导致习惯性流产的发生.

  20. sHLA-G1 and HLA-G5 levels are decreased in Tunisian women with multiple abortion.

    Zidi, Inès; Rizzo, Roberta; Bouaziz, Aicha; Laaribi, Ahmed Baligh; Zidi, Nour; Di Luca, Dario; Tlili, Henda; Bortolotti, Daria

    2016-04-01

    Pregnancy is associated with increased levels of soluble (s) human leukocyte antigen (HLA)-G molecules, while during abortion these molecules are decreased. To date, little is known about the role of sHLA-G isoforms during abortion. In this study, we investigated the levels of total sHLA-G and its isoforms: HLA-G1 (membrane shedded isoform) and alternative spliced HLA-G5 in plasma samples obtained from 55 women who had experienced spontaneous abortion, 108 pregnant healthy women and 56 non pregnant healthy women. We found that pregnant women exhibited higher amounts of sHLA-G compared to either non pregnant women or women with abortion. Among women who had experienced spontaneous abortion, women with recurrent abortions (RSA) had lower sHLA-G than women with only one abortion. In particular, RSA women were characterized by the absence of sHLA-G1 isoform, suggesting a possible implication in abortion event. PMID:26812178

  1. THE RELATIONSHIP BETWEEN MACROPHAGE MIGRATION INHIBITORY FACTOR EXPRESSION AND RECURRENT SPONTANEOUS ABORTION%巨噬细胞移动抑制因子表达与复发性自然流产关系

    孙素梅; 刘芙蓉; 詹瑛; 叶元华; 张宁

    2011-01-01

    Objective To investigate the expression of macrophage migration inhibitory factor (MIF) in serum and villi in early pregnancy and their association with recurrent spontaneous abortion (RSA). Methods A total of 35 RSA patients (RSA group) and 45 normal early pregnant women undergoing artificial abortion (control group) were recruited. The expressions of MIF mRNA and MIF protein in villi and deciduas were determined by SP method; the MIF mRNA expression in villi and deciduas by reverse transcriptase-polymerase chain reaction (RT-PCR) ; the serum MIF levels were detected by using enzyme-linked immunosorbent assay (ELISA). Results MIF protein was expressed in trophoblastic cells and decidual cells of both groups, the color of MIF in RSA was pale brown, that in the control was dark brown. The expressions of MIF protein and MIF mRNA in the pregnant tissues of RSA group were significantly lower than the control group, showing a significant difference between the two groups (t= 7. 089-40. 610,P<0. 01). The serum MIF levels in RSA group were lower than that in the control group (t=8. 903,P<0. 01).The serum levels of MIF in early pregnancy were positively correlated with the expression of MIF mRNA (r= 0. 873,0. 657 ; P< 0. 01), and MIF protein in villi and decidua (r=0. 794,0. 616;P<0.01). Conclusion Low expression of MIF mRNA and its protein in villi and decidua of RSA patients are probably involved in the pathogenesis of the disease, a decline of serum MIF in early pregnancy is of s predictive role for the occurrence of this condition.%目的 探讨巨噬细胞移动抑制因子(MIF)在早期妊娠妇女血清和妊娠组织中的表达及其与复发性自然流产(RSA)的关系.方法 采用免疫组化链霉菌抗生物素蛋白-过氧化物酶连接(SP)方法,检测35例RSA病人、45例人工流产的正常妊娠妇女(对照组)早期妊娠绒毛和蜕膜组织中MIF的定位与蛋白表达,采用RT-PCR技术检测绒毛和蜕膜组织MIF mRNA表达水平,

  2. Cytogenetic studies in 346 couples with recurrent spontaneous abortions of Guangdong%广东部分地区346对两次以上自然流产夫妇的细胞遗传学检查

    易翠兴; 李东至; 胡舜妍; 刘晗; 钟惠珠; 潘敏; 袁思敏; 徐丽萍; 廖灿

    2011-01-01

    目的:分析比较染色体异常与多次自然流产的关系.方法对有两次以上(含两次)自然流产史的346对夫妇进行了外周血染色体核型分析.每个病例观察20个细胞,分析3-5个核型.结果 本文346对(692例)两次以上自然流产夫妇中检出78例染色体核型异常及变异者,检出率为11.3%,其中平衡易位占2.5%;检出臂间倒位占1.9%;D与G组染色体多态性占4.2%:1,、9、16号染色体异染色质增多者占1.3%;另外检出Y=G和Y=18号染色体共10例,占1.45%.结论 染色体核型异常与反复性自然流产存在着一定的联系,D与G组染色体多态性,1,、9、16号染色体异染色质增多在反复性自然流产人群的检出率颇高,应引起重视.%Objective; To investigate the relationship between Recurrent spontaneous Abortions and chromosomal abnormality. Method; Peripheral blood were obtained from 346 couples with recurrent miscarriages, and all the samples were cultured for karyotype analysis, For each case ,3-5 karyotypes out of 20 observed cells were analysized under microscope. Result: 78 abnormal chromosome karyotypes were detected in 346couples (692cases). The abnormality detection rate was 11. 3% , Among the total; the rate of balanced translocation was 2. 5% ; rate of pericentric inversion was 1.3%; the rate of chromosomal polymorphism of group D and C was 4.2% ; the polymorphism in chromosome 1, 9, 16 takes a ratio of 1. 3% , in addition we detected that 10 cases of polymorphism in chromosome Y which takes a ratio of 1.45%. Conclusion; the chromosome abnormality may be an important cause of recurrent miscarriages, and in these cases detected the rate of chromosomal polymorphism of group D and G and in chromosome 1、9、16 were significantly high, we shoud pay more attention to it. Also it's necessary to analysis karyotypes of recurrent miscarriage couples.

  3. [Abortion law in Italy].

    Havránek, F

    1979-04-01

    On May 28, 1978, the Italian senate passed a law legalizing abortions. The law, passed against the will of the Christian Democrat party and the Vatican, is the most liberal in Western Europe. Any woman 18 or older is free to seek an abortion at a private or public institution during the first 90 days of pregnancy. Abortions can be sought on health, economic, social, family, or psychological grounds. A woman requests an abortion at a hospital or clinic, or from a physician. If termination is deemed urgent, the procedure may be performed immediately. If a request is denied, a woman may make another request 7 days later. Second trimester abortions are permitted only if grave danger to the woman or deformation of the fetus is suspected. Women under 18 meed the permission of their parents or legal guardians; a court may also grant permission. Passage of the law has facilitated open debate on the legal and medical aspects of abortion. It has also guaranteed women access to abortions. Physicians, who on grounds of conscience feel they can't perform abortions, may register to be exempt from having to perform them. They may not, however, deny a woman care before and after her abortion, and if they perform the procedure even once, their name is removed from the exempt register. Additionally, all physicians are bound to attempt to preserve the life of all women as well as any fetus which shows life outside the womb. PMID:445601

  4. Expression of C-type lectin receptors and Toll-like receptors in decidua of unexplained recurrent spontaneous abortion. Expression of C-type lectin receptors and Toll-like receptors in decidua of unexplained recurrent spontaneous abortion%C 型凝集素受体和 Toll 样受体在原因不明复发性流产患者蜕膜中的表达

    邱添; 滕银成; 王玉东; 徐亮

    2014-01-01

    目的:研究原因不明复发性流产(URSA)患者蜕膜中树突细胞(DC)特异性细胞间黏附分子-3结合非整合素因子(DC-SIGN)和甘露糖受体( MR)及 Toll 样受体2(TLR-2)和 TLR-4的表达情况。方法:采集 URSA 患者及正常妊娠人工流产妇女(对照组)的新鲜蜕膜。采用免疫组化和 Western blot 法检测蜕膜中 DC-SIGN、MR、TLR-2和TLR-4蛋白表达,RT-PCR 检测蜕膜中 DC-SIGN、MR、TLR-2和 TLR-4 mRNA 表达;流式细胞检测蜕膜中 DC 表面表达 DC-SIGN、MR、TLR-2和 TLR-4的水平。结果:与对照组比较, URSA 组蜕膜中及 DC 表面的 TLR-2和 TLR-4表达水平明显升高(P0.05)。结论:相对于正常妊娠妇女,URSA 患者蜕膜中及树突细胞表面的 C 型凝集素受体(CLRs)弱势表达,而 TLRs 优势表达。 CLRs 与 TLRs 之间的免疫平衡失调可能是 UR-SA 发病机制中的重要因素之一。%Objective:To investigate the expression of C-typed lectin receptors (CLRs) of DC-SIGN and MR and Toll-like receptors (TLRs) of TLR-2 and TLR-4 in decidua of unex-plained recurrent spontaneous abortion( URSA) patients. Methods:The decidua tissues were obtained from URSA patients (URSA group,n =20) and normal pregnant women (NP group,n= 20). The expressions of DCSIGN,MR,TLR-2 and TLR-4 protein in decidua were detected by immunohistochemistry and Western blot. The levels of DCSIGN,MR,TLR-2 and TLR-4 mRNA in decidua were detected by RT-PCR. The expressions of DCSIGN,MR,TLR-2 and TLR-4 mol-ecule on DC were detected by flow cytometry. Results:The expressions of TLR-2 and TLR-4 on DC and in decidua in URSA group were higher than that in NP group (P0. 05). Conclusion:Compared with normal pregnant women,the weak expression of CLRs and the overexpression of TLRs were observed in decidua in URSA patients. The imbal-ance between CLRs and TLRs may play an important role in the pathogenesis of URSA.

  5. "Conservative" views of abortion.

    Devine, P E

    1997-01-01

    The introduction to this essay, which presents and defends the "conservative" position on abortion, explains that this position holds that 1) abortion is wrong because it destroys the fetus; 2) the fetus has full personhood from conception (or very near conception); 3) abortion is only justified under special circumstances, such as when the pregnancy poses a threat to the woman's life; and 4) these conclusions should be reflected in law and public policy. Part 2 sets forth the moral foundations for this position. The third part considers the status of the fetus and reviews the various arguments that have been forwarded to resolve the question, such as the species principle, the potentiality principle, the sentience principle, and the conventionalist principle. Part 4 applies the conservative position to problems posed by hard cases, determines that abortion is a form of homicide from two weeks after fertilization (at the latest), reviews circumstances in which various legal definitions of homicide are applicable, argues for the denial of abortion funding by the state, and notes that violent militancy is not the appropriate response to a belief that abortion should be illegal. Section 5 refutes objections to the conservative position based on the fact that some opponents of abortion also oppose contraception, based on feminist ideals, and based on calls for religious freedom in a pluralistic society. In conclusion, the labels applied to the abortion debate are examined, and it is suggested that "communitarian" is the best term for the conservative position. PMID:12348327

  6. Abortion in Adolescence.

    Campbell, Nancy B.; And Others

    1988-01-01

    Explored differences between 35 women who had abortions as teenagers and 36 women who had abortions as adults. Respondents reported on their premorbid psychiatric histories, the decision-making process itself, and postabortion distress symptoms. Antisocial and paranoid personality disorders, drug abuse, and psychotic delusions were significantly…

  7. Abortion in Zambia

    Coast, Ernestina; Freeman, Emily

    2015-01-01

    The poster, based on 112 in-depth interviews conducted in 2014 with women in Zambia who had recently had an abortion, shows the complex pathways that some women take despite safe abortion being legal under a wide range of circumstances in Zambia.

  8. Abortion: the new debate.

    Callahan, D

    1986-06-01

    The course of the debate on abortion following the 1973 Supreme Court decision legalizing abortion has been marked by a variety of medical and scientific developments. Many of these new developments have important legal, psychologic, social, moral, and political implications. The cumulative impact of all these developments may pose a significant challenge to the social and legal foundations of Roe v. Wade. PMID:3523563

  9. Access to legal abortion.

    1993-10-01

    Countries are grouped by the nature and extent of access to legal abortion. The categories include abortion on demand, for social reasons, for health reasons, for rape or incest or to save a mother's life, and only to save a mother's life. Abortion on demand is available for about 40% of the world's population and may have restrictions, such as parental consent or approval of state committees or physicians. There are 22 countries in Europe, 12 in the former Soviet Union, four in Asia, four in the Americas, one in the Middle East (Turkey), and one in Africa (Tunisia) which provide access to early abortion on demand. Abortion for social and economic reasons is available to 21% of the world's population in five countries in Asia, three in Europe (Great Britain, Finland, and Hungary), and one in Africa (Zambia). Abortion for health reasons is available to 16% of the world's population located in 21 countries in Africa, eight in the Americas, seven in Asia, five in Europe, and four in the Middle East. Laws governing about 5% of the world's population permit abortion only in the case of rape, incest, or when a mother's life is in danger (Brazil, Mexico, and Sudan). 18% of the world's population is covered by laws which permit an abortion only when a mother's life is in danger; this includes 19 countries in Africa, 11 in the Americas, nine in Asia, seven in the Middle East, and one in Europe (Ireland). PMID:12287145

  10. Effects of Abortion Legalization in Nepal, 2001–2010

    Henderson, Jillian T.; Puri, Mahesh; Blum, Maya; Harper, Cynthia C.; Rana, Ashma; Gurung, Geeta; Pradhan, Neelam; Regmi, Kiran; Malla, Kasturi; Sharma, Sudha; Grossman, Daniel; Bajracharya, Lata; Satyal, Indira; Acharya, Shridhar; Lamichhane, Prabhat; Darney, Philip D.

    2013-01-01

    Background Abortion was legalized in Nepal in 2002, following advocacy efforts highlighting high maternal mortality from unsafe abortion. We sought to assess whether legalization led to reductions in the most serious maternal health consequences of unsafe abortion. Methods We conducted retrospective medical chart review of all gynecological cases presenting at four large public referral hospitals in Nepal. For the years 2001–2010, all cases of spontaneous and induced abortion complications were identified, abstracted, and coded to classify cases of serious infection, injury, and systemic complications. We used segmented Poisson and ordinary logistic regression to test for trend and risks of serious complications for three time periods: before implementation (2001–2003), early implementation (2004–2006), and later implementation (2007–2010). Results 23,493 cases of abortion complications were identified. A significant downward trend in the proportion of serious infection, injury, and systemic complications was observed for the later implementation period, along with a decline in the risk of serious complications (OR 0.7, 95% CI 0.64, 0.85). Reductions in sepsis occurred sooner, during early implementation (OR 0.6, 95% CI 0.47, 0.75). Conclusion Over the study period, health care use and the population of reproductive aged women increased. Total fertility also declined by nearly half, despite relatively low contraceptive prevalence. Greater numbers of women likely obtained abortions and sought hospital care for complications following legalization, yet we observed a significant decline in the rate of serious abortion morbidity. The liberalization of abortion policy in Nepal has benefited women’s health, and likely contributes to falling maternal mortality in the country. The steepest decline was observed after expansion of the safe abortion program to include midlevel providers, second trimester training, and medication abortion, highlighting the importance

  11. Living conditions, contraceptive use and the choice of induced abortion among pregnant women in Denmark

    Rasch, Vibeke; Wielandt, Hanne; Knudsen, Lisbeth B

    2002-01-01

    AIMS: This study describes women with induced abortion and thereby elucidates how living conditions and contraceptive failure are associated with the choice of induced abortion in a population of Danish pregnant women. METHODS: The study population consisted of pregnant women attending Odense...... University Hospital. They were categorized in two groups: women with induced abortion (n = 373) and a reference group consisting of women with spontaneous abortion and antenatal care attendees (n = 2,176). The two groups were compared by use of a case-referent design. The variables studied comprise age...... choice of induced abortion. Among married/cohabiting women aged 20-39 with fewer than two children, being under education, unemployed, on leave, or willing to invest effort in obtaining a more satisfying job influenced the choice of induced abortion. CONCLUSIONS: To reduce the number of induced abortions...

  12. Genetic Analysis and Its Clinical Effect of Spontaneous Abortion after Assisted Reproductive Techniques%辅助生殖技术治疗后自然流产胚胎的遗传学分析及其临床效应

    段程颖; 李红; 刘敏娟; 陈瑛; 孙健; 丁扬; 丁洁; 王玮

    2014-01-01

    Objective:To analyze the chromosome abnormalities of spontaneous abortion tissues after assisted reproductive techniques (ART),and to discuss the relationship between genetic change and clinical feature. Methods:40 cases of spontaneous abortion villuses from ART, and 113 cases from natural pregnancy as control, were studied by the routine G banding karyotyping after the standard cell culture and harvest. Those cases of culture failure or without culture were analyzed by the multiplex ligation-dependent probe amplification (MLPA). Results: ①There was no significant difference in the rates of abnormal karyotyping between the ART group (50%, 20 cases) and the control group(53.1%,60 cases,P>0.05).②There were no significant differences in the rates of abnormal karyotyping when analyzed those parameters, including women age, primary or secondary infertility, infertility cause (male, female, or both), cycle type (fresh or frozen) (P>0.05). Although there was significant difference in this rate when analyzed IVF method (routine IVF and ICSI) in the limited cases(P<0.05), it should be further studied in more cases. Conclusions:Chromosome abnomalities are the main reason of spontaneous abortion after ART. The combined genetic techniques to detect the spontaneous abortion tissues are helpful for the ART treatment of infertility.%目的:研究辅助生殖技术(ART)后自然流产胚胎的染色体异常率及遗传学改变与临床相关性。方法:选取经ART治疗妊娠后自然流产患者绒毛40例作为实验组,并选取正常自然流产患者绒毛113例作为对照组。2组绒毛经细胞培养,常规染色体制备后进行核型分析,培养失败或无法培养的绒毛应用多重连接依赖的探针扩增(MLPA)技术进行检测。结果:①实验组染色体核型异常20例,异常率为50.0%;对照组染色体异常核型60例,异常率53.1%,2组异常率差异无统计学意义(P>0.05);②实验组妊娠妇女不

  13. Legalized abortion in Japan.

    Hart, T M

    1967-10-01

    The enactment of the Eugenic Protection Act in Japan was followed by many changes. The population explosion was stemmed, the birth rate was halved, and while the marriage rate remained steady the divorce rate declined. The annual total of abortions increased until 1955 and then slowly declined. The highest incidence of abortions in families is in the 30 to 34 age group when there are four children in the family. As elsewhere abortion in advanced stages of pregnancy is associated with high morbidity and mortality. There is little consensus as to the number of criminal abortions. Reasons for criminal abortions can be found in the legal restrictions concerning abortion: Licensing of the abortionist, certification of hospitals, taxation of operations and the requirement that abortion be reported. Other factors are price competition and the patient's desire for secrecy. Contraception is relatively ineffective as a birth control method in Japan. Oral contraceptives are not yet government approved. In 1958 alone 1.1 per cent of married women were sterilized and the incidence of sterilization was increasing. PMID:6062283

  14. Legalized Abortion in Japan

    Hart, Thomas M.

    1967-01-01

    The enactment of the Eugenic Protection Act in Japan was followed by many changes. The population explosion was stemmed, the birth rate was halved, and while the marriage rate remained steady the divorce rate declined. The annual total of abortions increased until 1955 and then slowly declined. The highest incidence of abortions in families is in the 30 to 34 age group when there are four children in the family. As elsewhere abortion in advanced stages of pregnancy is associated with high morbidity and mortality. There is little consensus as to the number of criminal abortions. Reasons for criminal abortions can be found in the legal restrictions concerning abortion: Licensing of the abortionist, certification of hospitals, taxation of operations and the requirement that abortion be reported. Other factors are price competition and the patient's desire for secrecy. Contraception is relatively ineffective as a birth control method in Japan. Oral contraceptives are not yet government approved. In 1958 alone 1.1 per cent of married women were sterilized and the incidence of sterilization was increasing. PMID:6062283

  15. Unintended Pregnancies, Restrictive Abortion Laws, and Abortion Demand

    Medoff, Marshall H.

    2012-01-01

    This study examines the effect restrictive state abortion laws have on the pregnancy resolution decisions of women with unintended pregnancies. The empirical results find that the abortion ratio and the abortion rate of unintended pregnancies are more sensitive to increases in the abortion price than previous estimates that analyzed total pregnancies (unintended and intended). A Medicaid funding restriction has very little effect on a state's abortion rate of unintended pregnancies, but cause...

  16. Rewriting abortion: deploying medical records in jurisdictional negotiation over a forbidden practice in Senegal.

    Suh, Siri

    2014-05-01

    Boundary work refers to the strategies deployed by professionals in the arenas of the public, the law and the workplace to define and defend jurisdictional authority. Little attention has been directed to the role of documents in negotiating professional claims. While boundary work over induced abortion has been extensively documented, few studies have examined jurisdictional disputes over the treatment of abortion complications, or post-abortion care (PAC). This study explores how medical providers deploy medical records in boundary work over the treatment of complications of spontaneous and induced abortion in Senegal, where induced abortion is prohibited under any circumstance. Findings are based on an institutional ethnography of Senegal's national PAC program over a period of 13 months between 2010 and 2011. Data collection methods included in-depth interviews with 36 health care professionals, observation of PAC services at three hospitals, a review of abortion records at each hospital, and a case review of illegal abortions prosecuted by the state. Findings show that health providers produce a particular account of the type of abortion treated through a series of practices such as the patient interview and the clinical exam. Providers obscure induced abortion in medical documents in three ways: the use of terminology that does not differentiate between induced and spontaneous abortion in PAC registers, the omission of data on the type of abortion altogether in PAC registers, and reporting the total number but not the type of abortions treated in hospital data transmitted to state health authorities. The obscuration of suspected induced abortion in the record permits providers to circumvent police inquiry at the hospital. PAC has been implemented in approximately 50 countries worldwide. This study demonstrates the need for additional research on how medical professionals negotiate conflicting medical and legal obligations in the daily practice of treating

  17. The problem of illegally induced abortion: results from a hospital-based study conducted at district level in Dar es Salaam

    Rasch, V; Muhammad, H; Urassa, E; Bergström, S

    2000-01-01

    Illegal abortion is known to be a major contributor to maternal mortality. The objective of the study was firstly to identify women with illegally induced abortion, (IA) and to compare them with women admitted with a spontaneous abortion (SA) or receiving antenatal care (AC), and secondly to desc...

  18. Induced abortion in Indonesia.

    Hull, T H; Sarwono, S W; Widyantoro, N

    1993-01-01

    Induced abortion is one of the most difficult sociomedical problems facing the Indonesian government. While well-known in traditional society, the practice was discouraged by all Indonesian religious groups, and forbidden by the Dutch colonial authorities. Although abortion was technically illegal under the criminal code, a judicial interpretation in the early 1970s permitted medical professionals to offer the procedure so long as they were discreet and careful. The numbers of medical abortions carried out in Indonesia rose dramatically, and there was evidence of matching declines in the incidence of morbidity and mortality caused by dangerous illegal procedures. Medical and community groups campaigned for a more liberal abortion law to protect legal practitioners and stamp out illegal traditional practices. Their efforts appeared to bear fruit in the draft Health Law, but when the law was passed by the legislature in late 1992, the issue was again clouded by contradictions and inconsistencies. PMID:8212094

  19. [Interregional project concerning abortion].

    Jourdain, A; Pierotti, D; Vinclair, M

    1979-01-01

    The law legalizing abortion in France was passed in 1975. To group information of a social and medical nature and to publish reports on their activities, a questionnaire was designed to be filled by physicians and nurses working in centers and hospitals performing abortion. There were 19,000 abortions performed in 1976, and 30,000 are expected to be performed in 1979. The questionnaire contains 80 questions gathering information on socieconomic data, on medical history, on the procedure of the intervention, and on the follow-up visit. A study done on 5700 questionnaires filled between 1976 and 1977 show that most abortion seekers belong to the middle class, and that pregnancy was due in 20% of cases to pill failure, and in 34% of cases to failure of behavioral methods, or to lack of contraception. 88% of patients declared themselves satisfied with the procedure. PMID:12309432

  20. Abortion and Selection

    Elizabeth Oltmans Ananat; Jonathan Gruber; Phillip B. Levine; Douglas Staiger

    2006-01-01

    The introduction of legalized abortion in the early 1970s led to dramatic changes in fertility behavior. Some research has suggested as well that there were important impacts on cohort outcomes, but this literature has been limited and controversial. In this paper, we provide a framework for understanding the mechanisms through which abortion access affects cohort outcomes, and use that framework to both address inconsistent past methodological approaches, and provide evidence on the long-run...

  1. 辅助生殖技术治疗后孕早期自然流产的绒毛细胞染色体分析%Chromosomal Analysis in Spontaneous Abortion during the First Trimester after Assisted Reproduction Technique Treatment

    李跃萍; 徐雯; 黎明红; 麦扬青; 陈竞茜; 闫庆峰

    2011-01-01

    Objective To know about chromosome abnormalities in spontaneous abortion during the first trimester after assisted reproduction technique treatment and to provide some data for eugenics. Methods A retrospective analysis was performed on 41 clinical spontaneous abortion cases during the first trimester following ART, which including in vitro fertilization-embryo transfer (IVF-ET) and intracytoplasmic sperm injection (ICSI) and frozen embryo transfer (F-ET) and intrauterine insemination (IUI). Cytogenetic analysis of the chorionic villi by cell culture and standard G-banding cytogenetic techniques was performed. Results Successful analysis was conducted in 30 specimens. Fifteen of 30 specimens had a chromosomal abnormality,accounting for 50%. The majorities were numerical abnormalities such as monosomy X (one case). Trisomies for chromosomes 11 cases, including 18 trisomies in one case, 16 trisomies in three cases, 15 trisomies in two case, 4 trisomies in one cases, 9 trisomies in one case, 2 trisomies in one case, mosaic trisomy 21 trisomies in two cases, and polyploidin one case were observed. 46, XX/47, XX, +mar karyotype was observed in one case. Conclusions ART abortion is closely related with embryo chromosome abnormalities. Aneuploidy is the major factor affecting embryonic development in spontaneous abortions during the first trimester after ART.%目的 了解辅助生殖技术(ART)治疗后孕早期自然流产的绒毛细胞染色体的异常情况,为优生优育工作作指导.方法 选择行体外受精-胚胎移植(IVF-ET)、单精子卵胞浆内显微注射( ICSI)、冻融胚胎移植(F-ET)及宫腔内人工授精(IUI)治疗后的自然流产绒毛标本41例,进行绒毛细胞培养及G显带,分析染色体核型.结果 41例标本中有30例培养成功,绒毛染色体异常15例,占50%.多数为数目异常,其中X单体1例,染色体三体11例(包括18三体1例,16三体3例,15三体2例,4号三体1例,9号三体1例,2号三体1

  2. THE OUTCOME OF PREGNANCY IN PATIENTS WITH THREATENED ABORTION

    Prathap

    2015-10-01

    Full Text Available OBJECTIVE: To assess the Outcome of pregnancy in patients with threatened abortion. METHODS: A Prospective observational study was done on 106 pregnant women with threatened abortion. Out comes in the form of antenatal complications, mode of delivery and postnatal co mplications were noted. Analysis of the data was done using SPSS version 13. RESULTS: In the study of 106 patients 18% had spontaneous abortion. Pre - labour rupture of membranes were seen in 20% of patients and 21% had preterm labour. Threatened abortion di d not affect mode of delivery. PPROM, preterm births were more in women presenting with first trimester bleeding; PIH, PROM, and postpartum complications were more in women presenting beyond 20 weeks gestation though statistically not significant. 13.2% of women had heavy bleeding at admission out of which 50% aborted subsequently – significantly higher than the light bleeding group. CONCLUSION: The overall maternal and perinatal outcome in women with threatened abortion is suboptimal. Women with heavy blee ding are more likely to abort than women with light bleeding. Among the prognostic factors, only the amount of bleeding had significant prognostic accuracy

  3. Diagnosis of Cervical Abortion by TransvaginaI Color Doppler Sonography : A Case Report

    Cervical abortion is a spontaneous abortion of an intrauterine pregnancy into the cervical canal where the abortus is retained by a closed external os, causing distension of the cervical canal. Cervical abortion should be distinguished from the cervical pregnancy. We present a case of cervical abortion diagnosed preoperatively by transvaginal sonography and color doppler imaging, and treated by dilatation and curettage. Charateristic transvaginal sonographic findings and identification of subtrophoblastic blood flow by color doppler imaging could allow differentiation of the cevical aborition from the cervical pregnancy

  4. Abortion in Present day Vietnam

    Nguyen Thanh Binh

    2012-01-01

    Full Text Available In recent years, the abortion rate in Vietnam has been likely rising. In rural area, this rate is a bit higher than in urban one. Young age groups’ abortion rate is relatively high and ofter higher than older age groups. The main reason is due to their limited awareness of contraceptive methods. Low education level also affects the abortion. The abortion of people at low education level is relatively high, but people with elementary school graduation has the lowest rate of abortion. The Northwest had the highest abortion rate, the lowest rate belonged to the South Central Coast. The abortion rate depends on each couple’s number of alive children. The highest abortion rate is of couples with 1 or 2 alive children. The majority of couples only have one time of abortion for 12 months before research timepoint.

  5. Medical Abortion in Primary Care : Pitfalls and Benefits

    Boersma, A. A.; Meyboom-de Jong, B.

    2009-01-01

    We describe jive pitfalls of medical abortion: ectopic pregnancy not terminated after misoprostol, but without negative side-effects; long-term vaginal blood loss with suspicious retained products which disappeared spontaneously; a patient with uterus myomatatosus with severe pain and retained produ

  6. Study of karyotypes in Case of Recurrent Abortions in Gujarat

    N. Parikh; Rawal, J; Oza, S; B. M. Patel; H. R. Jadav; C A Pensi

    2015-01-01

    Introduction: - The biological definition of miscarriage is the expulsion of the conceptus before viability has been achieved. The definition of recurrent miscarriage is three or more consecutive spontaneous abortions. The risk factors for recurrent miscarriage are epidemiological, genetic, anatomical disorders, endocrinal, reproductive tract infections, thrombophilic disorders, disorders of materno-fetal alloimmune relationships, environmental effects and psychological causes. About 50% to 6...

  7. Grief and Mourning Reactions Following Abortion and Miscarriage.

    Widener, Anmarie J.

    1996-01-01

    Explores current research on psychological reactions following induced and spontaneous abortions. Provides examples of studies wherein researchers have used a loss model to understand this experience. Explores possible reasons for the apparent inattention to grief reactions following this type of loss and offers an alternative approach to the loss…

  8. The study of chromosomal abnormalities and heteromorphism in couples with 2 or 3 recurrent abortions in Shahid Beheshti Hospital of Hamedan

    Atefeh Asgari; Safieh Ghahremani; Solmaz Saeedi; Ebrahim Kamrani

    2013-01-01

    Background: Different studies show that chromosomal balance translocation in the parents can cause recurrent spontaneous abortions. Incidence of chromosomal translocation abnormalities in couples with repeated abortions is from 0% to 31%. Objective: The purpose of this research was studying the presence or absence of chromosomal abnormalities and heteromorphism in couples with recurrent abortions and also the role of this anomaly in the abortions. Materials and Methods: This study is a cross ...

  9. The Response of Abortion Demand to Changes in Abortion Costs

    Medoff, Marshall H.

    2008-01-01

    This study uses pooled cross-section time-series data, over the years 1982, 1992 and 2000, to estimate the impact of various restrictive abortion laws on the demand for abortion. This study complements and extends prior research by explicitly including the price of obtaining an abortion in the estimation. The empirical results show that the real…

  10. Abortion: sin or crime?

    Kulpys, Žydrūnas

    2005-01-01

    Abortą nagrinėja ir moralinė teologija, ir kanonų teisė. Moralinė teologija gvildeną abortą kaip didelį moralinį blogį ir sunkią nuodėmę. Kanonų teisė nagrinėja abortą ir kaip teisinį nusikaltimą, už kurį automatiškai skiriama griežta sankcija - ekskomunikavimas. Kokiomis aplinkybėmis abortas yra nuodėmė ir kada jis tampa ir teisiniu nusikaltimu, automatiškai užtraukiančiu atskyrimą nuo Bažnyčios - ekskomunikavimą? Vien tik aborto nuodėmė neužtraukia ekskomunikos. Nors abortas yra sunki nuodė...

  11. Unsafe abortion in rural Tanzania

    Rasch, Vibeke; Sørensen, Pernille H; Wang, Anna R;

    2014-01-01

    BackgroundThe circumstances under which women obtain unsafe abortion vary and depend on the traditional methods known and the type of providers present. In rural Tanzania women often resort to traditional providers who use plant species as abortion remedies. Little is known about how these plants...... are used and their potential effect.MethodsData were obtained among women admitted with incomplete abortion at Kagera Regional Hospital during the period January - June, 2006. The women underwent an empathetic interview to determine if they had experienced an unsafe abortion prior to their admission....... In all 125/187 women revealed having had an unsafe abortion. The women identified as having had an unsafe abortion underwent a questionnaire interview where information about abortion provider and abortion method used was obtained through open-ended questions. To get more detailed information about...

  12. Did Legalized Abortion Lower Crime?

    2001-01-01

    This paper examines the relationship between the legalization of abortion and subsequent decreases in crime. In a current study, researchers estimate that the legalization of abortion explains over half of the recent decline in national crime rates. The association is identified by correlating changes in crime with changes in the abortion ratio weighted by the proportion of the criminal population exposed to legalized abortion. In this paper, I use an alternative identification strategy. I an...

  13. A Shiite perspective toward abortion

    Kiarash Aramesh

    2006-01-01

    All schools of Islamic jurisprudence regard abortion as wrong and forbidden and allow abortion only before the stage of ensoulment, if the continuation of pregnancy would endanger the mother's life or put her into intolerable difficulties. In this article we describe and assess the viewpoint of Shiite jurisprudence toward abortion. "nUsing a selected collection of related references, and discussion describes with experts, this article the abortion in Shiite jurisprudence."nIn t...

  14. CMA abortion survey.

    1983-01-01

    Responses to the question as to whether abortions should be performed at the woman's request during the first trimester of pregnancy were evenly divided. There was support for abortion on socioeconomic grounds, during the first trimester, from 61.5% of the respondents. Termination of pregnancy beyond the first trimester was supported by a majority of the respondents only in cases in which the woman's life is in danger (73.9%) or in which there is evidence of a severe physical abnormality in t...

  15. Hospital admission following induced abortion in Eastern Highlands Province, Papua New Guinea--a descriptive study.

    Lisa M Vallely

    Full Text Available In Papua New Guinea abortion is restricted under the Criminal Code Act. While safe abortions should available in certain situations, frequently they are not available to the majority of women. Sepsis from unsafe abortion is a leading cause of maternal mortality. Our findings form part of a wider, mixed methods study designed to identify complications requiring hospital treatment for post abortion care and to explore the circumstances surrounding unsafe abortion.Through a six month prospective study we identified all women presenting to the Eastern Highlands Provincial Hospital following spontaneous and induced abortions. We undertook semi-structured interviews with women and reviewed individual case notes, extracting demographic and clinical information.Case notes were reviewed for 56% (67/119 of women presenting for post abortion care. At least 24% (28/119 of these admissions were due to induced abortion. Women presenting following induced abortions were significantly more likely to be younger, single, in education at the time of the abortion and report that the baby was unplanned and unwanted, compared to those reporting spontaneous abortion. Obtained illegally, misoprostol was the method most frequently used to end the pregnancy. Physical and mechanical means and traditional herbs were also widely reported.In a country with a low contraceptive prevalence rate and high unmet need for family planning, all reproductive age women need access to contraceptive information and services to avoid, postpone or space pregnancies. In the absence of this, women are resorting to unsafe means to end an unwanted pregnancy, putting their lives at risk and putting an increased strain on an already struggling health system. Women in this setting need access to safe, effective means of abortion.

  16. College Students' Attitudes Toward Abortion

    Maxwell, Joseph W.

    1970-01-01

    Attitudes toward the desirability of abortion were significaantly related to sex, college, classification, level of church activity, residence background, family size, exposure to abortion, and attitude toward premarital sex. The data suggest an increasing acceptance of abortion in the future. (Author)

  17. Did Legalized Abortion Lower Crime?

    Joyce, Ted

    2004-01-01

    Changes in homicide and arrest rates were compared among cohorts born before and after legalization of abortion and those who were unexposed to legalized abortion. It was found that legalized abortion improved the lives of many women as they could avoid unwanted births.

  18. Radioimmunological methods of determining hormones in the blood in physiological pregnancy and in abortions and premature delivery

    Significant changes are shown to occur in the level of sex hormones in blood at the risk of spontaneous abortion, missed abortion, or the mole. Determining the levels of estradiol, progesterone, chorial gonadotropin and testosterone in the blood serum using RIA yields immediate information on the hormonal function of the fetoplacental unit. This has diagnostic significance and can be used as a criterion for the application of complementary hormonal therapy when there is a risk of abortion or premature delivery. (author)

  19. Estudio citogenético y morfológico en productos de aborto espontáneo procedentes de diferentes servicios de ginecoobstetricia de la ciudad de Medellín Cytogenetic and morphologic study of spontaneous abortions products in Medellín, Colombia

    Gonzálo Vásquez Palacio

    1998-04-01

    Full Text Available En el período comprendido entre septiembre 1° de 1996 y octubre 1° de 1997, se recolectó para estudios morfológico y citogenético un total de 84 productos de aborto espontáneo del 1° y 2° trimestres de la gestación, en diferentes servicios de ginecoobstetricia de la ciudad de Medellín. Dieciséis de los 84 se descartaron por contaminación o ausencia de tejidos apropiados para el estudio. De los 68 productos restantes en 60 (88,2% se establecieron cultivos para estudio citogenético, los cuales fueron exitosos en 34 casos (56, 7%. Diecisiete de los anteriores (50% mostraron un cariotipo anormal con las siguientes alteraciones cromosómicas: monosomía X, 10 (58,8%, mosaicismos 5 (29,4%, trisomías 1 (5,9% y tetraploidía 1 (5,9%. En 21 de los 68 productos (30,9% (3 embriones y 18 fetos fue posible el estudio morfológico. Doce de éstos, (2 embriones y 10 fetos; 57, 1 % mostraron alteraciones morfológicas externas o internas. El presente estudio citogenético y morfológico en productos de aborto espontáneo con edad gestacional menor de 20 semanas es el primero que se informa en nuestro medio y sus resultados son similares a los obtenidos en otros reportes que aparecen en la literatura. Eighty tour spontaneous abortion products, with gestational age under 20 weeks, were collected in ditterent obstetric and gynecologic services trom Medellin-Colombia between September 1996 and October 1997; they were studied both morphologically and cytogenetically. Sixteen of those products were discarded because of contamination or absence of suitable tissues for the study In 60 of the remaining 68 products (88°/~ cultures for cytogenetic studies were establishedJ and they were succesful in 34 cases (56J7%. Seventeen of. these (50% showed an abnormal karyotype with the following chromosomal anomalies: X monosomies 10 (58J8%, mosaicisms 5 (29,4%J trisomies 1 (5,9%, and tetráploidy 1 (5J9%. From the 68 products, a morphologic study was performed in

  20. Study of karyotypes in Case of Recurrent Abortions in Gujarat

    N. Parikh

    2015-06-01

    Full Text Available Introduction: - The biological definition of miscarriage is the expulsion of the conceptus before viability has been achieved. The definition of recurrent miscarriage is three or more consecutive spontaneous abortions. The risk factors for recurrent miscarriage are epidemiological, genetic, anatomical disorders, endocrinal, reproductive tract infections, thrombophilic disorders, disorders of materno-fetal alloimmune relationships, environmental effects and psychological causes. About 50% to 60% of all first trimester abortions are associated with derangement of one or more chromosomal complements. Aim: - The aim of this study was to assess frequency and increasing the awareness of physician about the nature of chromosomal aberration that contribute to the occurrence of repeated abortions. Material & Methods: - Patient of recurrent abortion was investigated by history taking, examination and investigations. For present study 20 women having two or more consecutive spontaneous abortions, who attended outdoor & indoor patient department, were selected and karyotyping was done. In 10 of the above cases karyotype study of both partners was done. So in total 30 individuals (20 females & 10 males were selected for Cytogenetic study. In all cases relevant history and clinical findings and other investigations were noted. Blood samples were obtained and karyotype study was performed at Genetic Laboratory, B. J. Medical College, Ahmedabad. Results and Conclusions: - Cytogenetic evaluation by karyotypes revealed robertsonian translocation in one (5% female; this patient had a history of 2 spontaneous abortions and two times IVF failure, she had history of chocolate cyst of ovary and family history of infertility. No numerical anomaly; mosaicism or inversions were found in this study; 23 cases had normal karyotype and remaining 6 cases came out inconclusive.

  1. Haemophilus influenzae Septic Abortion

    Sharon L. Hillier

    2002-01-01

    Full Text Available Background: Haemophilus influenzae septic abortion is typically caused by nontypeable strains of the organism. Furthermore, nontypeable species with a special affinity for the genital tract are the most frequent isolates encountered, and an ascending vaginal or cervical infection is often the suspected route of transmission.

  2. Abortion: Strong's counterexamples fail

    Di Nucci, Ezio

    2009-01-01

    This paper shows that the counterexamples proposed by Strong in 2008 in the Journal of Medical Ethics to Marquis's argument against abortion fail. Strong's basic idea is that there are cases--for example, terminally ill patients--where killing an adult human being is prima facie seriously morally...

  3. Prematurity and Abortion

    Francisco Jover-Díaz

    2001-01-01

    Full Text Available Background: Although the pathogenic role of Coxiella burnetii infection during pregnancy is controversial, some cases of stillbirth and abortion occurring after an acute or chronic infection have been mentioned in the literature. Recently, Q fever has been advocated as a significant cause of morbidity and mortality in pregnancy

  4. Knowledge and feelings of women who experienced an abortion process

    Tereza Cristina Vidal Menezes; Francisca Elisângela Teixeira Lima; Karla Maria Carneiro Rolim

    2008-01-01

    Objective: To identify the knowledge and feelings of women in face of the loss of their child by an abortion process. Methods: It was a descriptive study, with a qualitative approach, carried out in a maternity-school of Fortaleza-CE. Ten women, in the age group between 22 and 39 years, who had been interned at the maternity after induced or spontaneous abortion, joined in the study. Data collection was performed with a semi-structured interview containing guiding questions related to the kno...

  5. Abortion health services in Canada

    Norman, Wendy V.; Guilbert, Edith R.; Okpaleke, Christopher; Hayden, Althea S.; Steven Lichtenberg, E.; Paul, Maureen; White, Katharine O’Connell; Jones, Heidi E.

    2016-01-01

    Abstract Objective To determine the location of Canadian abortion services relative to where reproductive-age women reside, and the characteristics of abortion facilities and providers. Design An international survey was adapted for Canadian relevance. Public sources and professional networks were used to identify facilities. The bilingual survey was distributed by mail and e-mail from July to November 2013. Setting Canada. Participants A total of 94 abortion facilities were identified. Main outcome measures The number and location of services were compared with the distribution of reproductive-age women by location of residence. Results We identified 94 Canadian facilities providing abortion in 2012, with 48.9% in Quebec. The response rate was 83.0% (78 of 94). Facilities in every jurisdiction with services responded. In Quebec and British Columbia abortion services are nearly equally present in large urban centres and rural locations throughout the provinces; in other Canadian provinces services are chiefly located in large urban areas. No abortion services were identified in Prince Edward Island. Respondents reported provision of 75 650 abortions in 2012 (including 4.0% by medical abortion). Canadian facilities reported minimal or no harassment, in stark contrast to American facilities that responded to the same survey. Conclusion Access to abortion services varies by region across Canada. Services are not equitably distributed in relation to the regions where reproductive-age women reside. British Columbia and Quebec have demonstrated effective strategies to address disparities. Health policy and service improvements have the potential to address current abortion access inequity in Canada. These measures include improved access to mifepristone for medical abortion; provincial policies to support abortion services; routine abortion training within family medicine residency programs; and increasing the scope of practice for nurses and midwives to include abortion

  6. Abortion: taking the debate seriously.

    Kottow Lang, Miguel Hugo

    2015-01-01

    Voluntarily induced abortion has been under permanent dispute and legal regulations, because societies invariably condemn extramarital pregnancies. In recent decades, a measure of societal tolerance has led to decriminalize and legalize abortion in accordance with one of two models: a more restricted and conservative model known as therapeutic abortion, and the model that accepts voluntary abortion within the first trimester of pregnancy. Liberalization of abortion aims at ending clandestine abortions and decriminalizes the practice in order to increase reproductive education and accessibility of contraceptive methods, dissuade women from interrupting their pregnancy and, ultimately, make abortion a medically safe procedure within the boundaries of the law, inspired by efforts to reduce the incidence of this practice. The current legal initiative to decriminalize abortion in Chile proposes a notably rigid set of indications which would not resolve the three main objectives that need to be considered: 1) Establish the legal framework of abortion; 2) Contribute to reduce social unrest; 3) Solve the public health issue of clandestine, illegal abortions. Debate must urgently be opened to include alternatives in line with the general tendency to respect women's decision within the first trimester of pregnancy. PMID:26057783

  7. The consequences of abortion legislation.

    Braude, M

    1983-01-01

    This article examines the consequences of the 1973 US Supreme Court decision legalizing abortion as well as potential implications of proposed legilation aimed at nullifying this decision. In addition to giving women the right to determine their own reproduction, legal abortion had had beneficial health effects for both mothers and infants. The partial reversal of abortion gains due to restrictions on public funding and limitations on how and where abortions can be performed has produced a slight increase in abortion mortality, but the impact has not been dramatic. Moreover, each year since 1973, women have been obtaining abortions earlier in pregnancy. Abortion may be experienced as a loss by the mother, but there is no evidence of serious psychological sequelae. In contrast, a large body of evidence supports the physical, psychological, and social benefits of legal abortion to women, children, and families. However, proponents of the proposed Human Life Amendment place protection of the rights of the fetus over all other considerations. Their antiabortion actions have challenged the medical tradition of privacy and the confidentiality of the doctor-patient relationship. Most supporters of legal abortion would prefer that there be fewer abortions; such a decrease is more likely as a result of better education and contraceptive methods rather than coercion. PMID:12340335

  8. Austerity and Abortion in the European Union.

    Lima, Joana Madureira; Reeves, Aaron; Billari, Francesco; McKee, Martin; Stuckler, David

    2016-06-01

    Economic hardship accompanying large recessions can lead families to terminate unplanned pregnancies. To assess whether abortions have risen during the recession, we collected crude abortion data from 2000 to 2012 from Eurostat for countries that had legal abortions and complete data. Declining trends in abortion ratios between 2000 and 2009 have been reversing. Excess abortions between 2010 and 2012 totaled 10.6 abortions per 1000 pregnancies ending in abortion or birth or 6701 additional abortions (95% CI 1190-9240) with stronger effects in younger ages. Economic shocks may increase recourse to abortion. Further research should explore causal pathways and protective factors. PMID:27009038

  9. Abortion Performance and Politics

    Candelario, Rosemary

    2012-01-01

    “Performing abortion” typically refers to what health care providers do in clinics, private offices, and (rarely) hospitals 1.21 million times per year,every year, in the United States. At the same time, the phrase indicates what performance artists, choreographers, and activists have been doing on stages, in galleries, and on the streets for decades. Candelario is intrigued by this double meaning that invites us to take seriously what abortion means at this political and historical moment, b...

  10. Abortion, Law and Ideology

    Claudia Escobar García

    2012-12-01

    Full Text Available This work explains that the discourses opposing the criminalization ofabortion and that reject the constitutional rules that protect human life,are an artificially constructed ideology made only to justify abortion,and hide the asymmetrical relations of power between women and theunborn. In order for this purpose, these arguments are identified andsubjected to critical analysis, demonstrating that it is purely emotionaland lacking fundaments.

  11. Abortion law reform in Nepal.

    Upreti, Melissa

    2014-08-01

    Across four decades of political and social action, Nepal changed from a country strongly enforcing oppressive abortion restrictions, causing many poor women's long imprisonment and high rates of abortion-related maternal mortality, into a modern democracy with a liberal abortion law. The medical and public health communities supported women's rights activists in invoking legal principles of equality and non-discrimination as a basis for change. Legislative reform of the criminal ban in 2002 and the adoption of an Interim Constitution recognizing women's reproductive rights as fundamental rights in 2007 inspired the Supreme Court in 2009 to rule that denial of women's access to abortion services because of poverty violated their constitutional rights. The government must now provide services under criteria for access without charge, and services must be decentralized to promote equitable access. A strong legal foundation now exists for progress in social justice to broaden abortion access and reduce abortion stigma. PMID:24890742

  12. Legal abortion and public health.

    Tietze, C

    1984-01-01

    Over 15 million abortions have been performed in the US since the process of abortion legalization began in 1967. Consequences of legalization have included a marked reduction of pregnancy-related mortality and the prevention in many cases of the birth of infants with major physical or mental defects. Prenatal diagnosis, backed up by selective abortion, has made procreation a possibility for many couples who might otherwise avoid childbearing. However, the number of abortions performed on the basis of prenatal diagnosis remains small, comprising only about .01% of all legal abortions. In recent months, the pro-choice movement in the US has been handed 2 important victories: the US Supreme Court reaffirmed the 1973 decision legalizing abortion and the US Senate defeated a constitutional amendment intended to reverse this decision. As a result of these victories, contributions to pro-choice groups have declined. Continued vigilance is needed to protect these victories. PMID:12267089

  13. The abortion debate in Australia.

    Read, Christine Margaret

    2006-09-01

    I recently watched a fascinating documentary about the crusade of Dr Bertram Wainer in the 1960s to bring the practice of illegal abortion in Victoria to an end. It documented the profound horror of the backyard abortion that so often ended in infection, sterility or death, and served as a potent reminder of a practice to which we must never return. Of course that cant happen again, abortion is legal now, isnt it? In Victoria in 1969 a Supreme Court judge ruled that an abortion is not unlawful if a doctor believed that: the abortion is necessary to preserve the woman from serious danger to her life or physical or mental health (Menhennit ruling). In Australia today however, abortion law remains conditional, unclear and inconsistent and, except in the ACT, is still part of criminal statutes. PMID:16969440

  14. Dworkin and Casey on abortion.

    Stroud, Sarah

    1996-01-01

    This article responds to two important recent treatments of abortion rights. I will mainly discuss Ronald Dworkin's recent writings concerning abortion: his article "Unenumerated rights: whether and how Roe should be overruled," and his book Life's Dominion. In these writings Dworkin presents a novel view of what the constitutional and moral argument surronding abortion is really about. Both debates actually turn, he argues, on the question of how to interpret the widely shared idea that human life is sacred. At the heart of the abortion debate is the essentially religious notion that human life has value which transcends its value to any particular person; abortion is therefore at bottom a religious issue. Dworkin hopes to use this analysis to show that the religion clauses of the First Amendment provide a "textual home" for a woman's right to choose abortion. I wish to scrutinize this suggestion here; I want to probe the precise consequences for abortion rights of such an understanding of their basis. I will argue that the consequences are more radical than Dworkin seems to realize. The other work I will examine here is the important 1992 Supreme Court decision on abortion, Planned Parenthood v. Casey. The controlling opinion in that case, written jointly by Justices Kennedy, O'Connor, and Souter, strongly reaffirmed Roe v. Wade, but also upheld most of the provisions of a Pennsylvania statute that had mandated various restrictions on abortion. The justices' basis for upholding these restictions was their introduction of a new constitutional standard for abortion regulations, an apparently weaker standard than those that had governed previous Supreme Court abortion decisions. I think there is a flaw in Casey's new constitutional test for abortion regulations, and I will explain, when we turn to Casey, what it is and why it bears a close relation to Dworkin's reluctance to carry his argument as far as it seems to go. PMID:11660187

  15. Psychiatric aspects of therapeutic abortion *

    Doane, Benjamin K.; Quigley, Beverly G.

    1981-01-01

    A search of the literature on the psychiatric aspects of abortion revealed poor study design, a lack of clear criteria for decisions for or against abortion, poor definition of psychologic symptoms experienced by patients, absence of control groups in clinical studies, and indecisiveness and uncritical attitudes in writers from various disciplines. A review of the sequelae of therapeutic abortion revealed that although the data are vague, symptoms of depression were reported most frequently, ...

  16. A Shiite perspective toward abortion

    Kiarash Aramesh

    2006-03-01

    Full Text Available All schools of Islamic jurisprudence regard abortion as wrong and forbidden and allow abortion only before the stage of ensoulment, if the continuation of pregnancy would endanger the mother's life or put her into intolerable difficulties. In this article we describe and assess the viewpoint of Shiite jurisprudence toward abortion. "nUsing a selected collection of related references, and discussion describes with experts, this article the abortion in Shiite jurisprudence."nIn the Shiite jurisprudence, the ensoulment occurs after about 4 months. Before this stage, all Shiite authorities regard abortion as forbidden (Hiram unless if continuing the pregnancy would put the mother's life in real danger or will be intolerable for her. But after that, they regard abortion as Hiram, unless in conditions in which continuing the pregnancy results in dying of both mother and fetus, but abortion will save the life of mother. However, the Shiite authorities have not accepted to legitimate abortion in unwanted pregnancies and even in pregnancies resulted from adultery (Zina or rape."nThe debate over abortion is still controversial as ever. There are some important and notable related Fatwas that make jurisprudical basis for some new and problem solving legal acts, showing the inherent and valuable flexibility of the Shiite jurisprudence in dealing with such important issues. Some related issues, such as the priority of saving the life of mother after ensoulment can be referred to jurisprudical authorities for more assessment.

  17. The Impact of Legalized Abortion on Crime

    Donohue, John J, III; Steven D. Levitt

    2000-01-01

    We offer evidence that legalized abortion has contributed significantly to recent crime reductions. Crime began to fall roughly 18 years after abortion legalization. The 5 states that allowed abortion in 1970 experienced declines earlier than the rest of the nation, which legalized in 1973 with Roe v. Wade. States with high abortion rates in the 1970s and 1980s experienced greater crime reductions in the 1990s. In high abortion states, only arrests of those born after abortion legaliz...

  18. The Impact of Legalized Abortion on Crime

    Donohue, John J.; Levitt, Steven D.

    2000-01-01

    We offer evidence that legalized abortion has contributed significantly to recent crime reductions. Crime began to fall roughly 18 years after abortion legalization. The 5 states that allowed abortion in 1970 experienced declines earlier than the rest of the nation, which legalized in 1973 with Roe v. Wade. States with high abortion rates in the 1970s and 1980s experienced greater crime reductions in the 1990s. In high abortion states, only arrests of those born after abortion legalization fa...

  19. Abortion - a philosophical perspective

    MN Jali

    2001-01-01

    The central issue in the abortion debate is the moral status of the conceptus. There are two positions that argue this issue. At one extreme are the views of the pro-life group which argues that human life begins at the moment of conception whilst at the other are views of the pro-choice group that argues in favour of a woman’s right to self-determination. Two basic principles come into conflict in this debate, namely the Value of Life and that of Self-determination. In this paper the argumen...

  20. Sociocultural determinants of induced abortion

    Objective: To determine the frequency of induced abortion and identity the role of sociocultural factors contributing to termination of pregnancy and associated morbidity and mortality in hospital setting. Subjects and Methods: The patients who were admitted for induced abortion were interviewed in privacy. On condition of anonymity they were asked about the age, parity, family setup and relationships, with particular emphasis on sociocultural reasons and factors contributing to induction of abortion. Details of status of abortionist and methods used for termination of pregnancy, the resulting complications and their severity were recorded. Results: Out of total admissions, 57(2.35%) gave history of induced abortion. All women belonged to low socioeconomic class and 59.6% of them were illiterate. Forty-three (75.5%) of these women had never practiced concentration. Twenty-four (42%) were grandmultiparae and did not want more children. In 29 women (50.9%) the decision for abortion had been supported by the husband. In 25 (43.8%) abortion was carried out by Daiyan (traditional midwives). Serious complications like uterine perforation with or without bowel injury were encouraged in 25 (43.8%) of these women. During the study period illegally induced abortion accounted for 6 (10.5%) maternal deaths. Conclusion: Prevalence of poverty, illiteracy, grand multiparity and non-practice of contraception are strong determinants of induced abortion. (author)

  1. Advice in the Abortion Decision

    Luscutoff, Sidney A.; Elms, Alan C.

    1975-01-01

    Subjects in this study were asked to report the number of contacts-for-advice they had made when forming decisions to have a therapeutic abortion, or to carry a pregnancy to term. As predicted, the abortion group differed strongly from both other groups on most questions. (Author)

  2. Birth, meaningful viability and abortion.

    Jensen, David

    2015-06-01

    What role does birth play in the debate about elective abortion? Does the wrongness of infanticide imply the wrongness of late-term abortion? In this paper, I argue that the same or similar factors that make birth morally significant with regard to abortion make meaningful viability morally significant due to the relatively arbitrary time of birth. I do this by considering the positions of Mary Anne Warren and José Luis Bermúdez who argue that birth is significant enough that the wrongness of infanticide does not imply the wrongness of late-term abortion. On the basis of the relatively arbitrary timing of birth, I argue that meaningful viability is the point at which elective abortion is prima facie morally wrong. PMID:25012846

  3. Teenage pregnancies and abortion.

    Morgenthau, J E

    1984-01-01

    The issue of abortion, except when it is rendered moot because the fetus endangers the life of the mother, is not really a medical issue. The physician's role is to help patients achieve and maintain their maximum potential for physical, mental, and social well-being. To accomplish this, the physician must acquire a constantly evolving database of scientific knowledge, must evaluate this information in a critical and ethical manner, and must be prepared to apply what is learned. In the realm of applied ethics, no particular religion, profession, culture, class, or sex should be thought of as having all the answers in the realm of applied ethics. This physician's actions are predicated on the belief that, to a large extent, ethical precepts reflect the broader social and economic issues of the period in which they are articulated. If this is the case, then in today's world the population explosion, the postindustrial society, the women's rights movement, inequality of access, and the ability to perform prenatal diagnosis are all factors which have molded the approach to the issue of abortion. Only the last 3 of these can in any way be considered as medical. When considering the role of a physician in dealing with the issue of abortion in the adolescent, this individual relies on the concept articulated by the World Health Association (WHA): promoting the physical, emotional, and social well-being of one's patients. Each year in the US over 1 million 15-19 year olds become pregnant, resulting in over 600,000 births. Most of these pregnancies are unintentional, yet approximately 90% of the infants are kept in the home by mothers who are ill prepared to be parents. What is most disturbing is that the pregnancy rate for the younger mother, 16 years or under, is accounting for an ever increasing percentage of the total. Studies at the Adolescent Health Center of the Mount Sinai Hospital in New York City as well as national studies suggest that the younger teens are more

  4. 药物流产和人工流产的效果观察及护理%The Effect of Drug Abortion and Abortion Observation and Nursing

    李春柏

    2015-01-01

    目的:探讨药物流产和人工流产的临床效果,并分析不同患者相应的护理方法。方法选取我院于2012年9月~2014年9月收治的68例需要实施流产的患者,按照患者意愿的不同将其分为药物流产组和人工流产组,观察两组患者流产后的临床特征及表现,并对其护理情况进行分析。结果通过对两组患者施以不同流产方法,人工流产组34例患者均为完全流产,药物流产组完全流产为30例,数据对比差异有统计学意义(P<0.05)。结论通过研究发现,药物流产和人工流产两种方案各有优缺点,应根据孕妇的具体情况制定合适的流产方案,并给予患者相应的护理措施,缓解患者的情绪,促进患者的康复。%Objective To explore the clinical effect of drug abortion and artificial abortion, and analyze the nursing methods of patients with different corresponding. Methods Select our hospital from September 2012 to September 2014 patients treated 68 cases need to implement an abortion, according to the wishes of patients with different it can be divided into medical abortion and artiifcial abortion group, two groups of patients with spontaneous abortion after the clinical features and performance, and analyze the nursing status.ResultsBy means of two groups of patients with different methods of abortion, abortion group of 34 patients were completely abortion, complete abortion of 30 cases of medical abortion group, data contrast significant difference was statistically significant (P<0.05).Conclusion Through the study found that medical abortion and abortion two plans each have advantages and disadvantages, should be based on appropriate abortion of pregnant women, patients and give corresponding nursing measures, alleviate the mood of patients, promote the recovery of patients.

  5. The Effect of Drug Abortion and Abortion Observation and Nursing%药物流产和人工流产的效果观察及护理

    李春柏

    2015-01-01

    Objective To explore the clinical effect of drug abortion and artificial abortion, and analyze the nursing methods of patients with different corresponding. Methods Select our hospital from September 2012 to September 2014 patients treated 68 cases need to implement an abortion, according to the wishes of patients with different it can be divided into medical abortion and artiifcial abortion group, two groups of patients with spontaneous abortion after the clinical features and performance, and analyze the nursing status.ResultsBy means of two groups of patients with different methods of abortion, abortion group of 34 patients were completely abortion, complete abortion of 30 cases of medical abortion group, data contrast significant difference was statistically significant (P<0.05).Conclusion Through the study found that medical abortion and abortion two plans each have advantages and disadvantages, should be based on appropriate abortion of pregnant women, patients and give corresponding nursing measures, alleviate the mood of patients, promote the recovery of patients.%目的:探讨药物流产和人工流产的临床效果,并分析不同患者相应的护理方法。方法选取我院于2012年9月~2014年9月收治的68例需要实施流产的患者,按照患者意愿的不同将其分为药物流产组和人工流产组,观察两组患者流产后的临床特征及表现,并对其护理情况进行分析。结果通过对两组患者施以不同流产方法,人工流产组34例患者均为完全流产,药物流产组完全流产为30例,数据对比差异有统计学意义(P<0.05)。结论通过研究发现,药物流产和人工流产两种方案各有优缺点,应根据孕妇的具体情况制定合适的流产方案,并给予患者相应的护理措施,缓解患者的情绪,促进患者的康复。

  6. 28 CFR 551.23 - Abortion.

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Abortion. 551.23 Section 551.23 Judicial..., Pregnancy, Child Placement, and Abortion § 551.23 Abortion. (a) The inmate has the responsibility to decide either to have an abortion or to bear the child. (b) The Warden shall offer to provide each...

  7. New German abortion law agreed.

    Karcher, H L

    1995-07-15

    The German Bundestag has passed a compromise abortion law that makes an abortion performed within the first three months of pregnancy an unlawful but unpunishable act if the woman has sought independent counseling first. Article 218 of the German penal code, which was established in 1871 under Otto von Bismarck, had allowed abortions for certain medical or ethical reasons. After the end of the first world war, the Social Democrats tried to legalize all abortions performed in the first three months of pregnancy, but failed. In 1974, abortion on demand during the first 12 weeks was declared legal and unpunishable under the social liberal coalition government of chancellor Willy Brandt; however, the same year, the German Federal Constitution Court in Karlsruhe ruled the bill was incompatible with article 2 of the constitution, which guarantees the right to life and freedom from bodily harm to everyone, including the unborn. The highest German court also ruled that a pregnant woman had to seek a second opinion from an independent doctor before undergoing an abortion. A new, extended article 218, which included a clause giving social indications, was passed by the Bundestag. When Germany was unified, East Germans agreed to be governed by all West German laws, except article 218. The Bundestag was given 2 years to revise the article; however, in 1993, the Federal Constitution Court rejected a version legalizing abortion in the first 3 months of the pregnancy if the woman sought counsel from an independent physician, and suggested the recent compromise passed by the Bundestag, the lower house of the German parliament. The upper house, the Bundesrat, where the Social Democrats are in the majority, still has to pass it. Under the bill passed by the Bundestag, national health insurance will pay for an abortion if the monthly income of the woman seeking the abortion falls under a certain limit. PMID:7613423

  8. Comparison of the effect of aspirin and heparin with or without intravenous immunoglobulin in treatment of recurrent abortion with unknown etiology: A clinical study

    Nazari, Zeinab; Ghaffari, Javad; Ebadi, Aghdas

    2015-01-01

    Introduction and Objective: Abortion is the most common complication of pregnancy, defined as spontaneous expulsion of products of conception before 24 weeks of pregnancy or termination of pregnancy with a fetus weighing

  9. 补体C3、C4在复发性自然流产发病机制中作用的探讨%Effect of Complement C3 and C4 in the pathogenesis of recurrent spontaneous abortion

    张新宇; 李晶晶

    2011-01-01

    [Objective] To investigate the effect of complement C3 and C4 in the recurrent spontaneous abortion (RSA). [Methods] Thirty women who had the history of RSA were involved in study group,in which fifteen of them without pregnancy were in study group I, and other women diagnosed as inevitable abortion were in study group II. Thirty normal women were in control group,according to pregnancy or not,they were divided into control group I and group II. Immunonephelo-metric assay was used to test complement C3 and C4 in the serum of all groups and shortcut immunohistochemistry staining was applied to observe complement C3 and C4 expression in villus tissue of two pregnant groups. [ Results] ① The complement C3 and C4 were (1070. 4 ± 240. 8) mg/L and (244. 2 ± 85. 8) mg/L in study group serum, and were (929. 9 ± 146.6) mg/L and (193. 1 ±65. 1) mg/L in the control group (P < 0. 05). ② The complement C3 and C4 were (1167.4 ± 142. 8) mg/L and (250. 9 ±81. 9) mg/L in study group II serum, and were (939. 1 ± 120. 1) mg/L and (202. 8 ±50.9) mg/L in the control group II (P <0.05). ③ In villus tissue of study group II and control group II,the average points positive intensity of complement C3 were (10. 1 ±4. 9) points and (2. 2 ± 1. 4) points, C4 were (6. 6 ± 5.3) points and (1.7 ±1.0) points (P<0.05). [Conclusions] The complement C3and C4 are increased in patients of RSA. Its activation may be one of immune pathogenesis in RSA.%[目的]探讨补体C3、C4在复发性自然流产(recurrent spontaneous abortion,RSA)发病机制中的作用.[方法]选取30例有RSA史患者为研究组,其中15例未孕者为研究组Ⅰ,15例难免流产者为研究组Ⅱ;30例正常妇女为对照组,其中15例未孕者为对照组Ⅰ,15例正常妊娠者为对照组Ⅱ.采用免疫散射比浊法检测各组血清中补体C3、C4值;采用快捷型免疫组化染色法检测两组妊娠者绒毛中补体C3、C4的表达情况.[结果]①研究组血清补体C3、C4

  10. The Question of Abortion in Serbia

    Rasevic, Mirjana

    2009-01-01

    Induced abortion has for a long time been a predominant method of birth control in Serbia. With spreading of contraception, significance of induced abortion became to a decrease. Besides this positive trend, estimated number of induced abortions about 200000 abortions per a year shows that a significant number of women mostly, and a certain number of women exclusively, relies on this method of birth control.Research findings discovered a complex array of factors of abortion problem, including...