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Sample records for abnormal procalcitonin levels

  1. Procalcitonin levels in salmonella infection

    Vikas Mishra

    2015-01-01

    Full Text Available Aim: Procalcitonin (PCT as a diagnostic marker for bacteremia and sepsis has been extensively studied. We aimed to study PCT levels in Salmonella infections whether they would serve as marker for early diagnosis in endemic areas to start empiric treatment while awaiting blood culture report. Materials and Methods: BACTEC blood culture was used to isolate Salmonella in suspected enteric fever patients. Serum PCT levels were estimated before starting treatment. Results: In 60 proven enteric fever patients, median value of serum PCT levels was 0.22 ng/ml, values ranging between 0.05 and 4 ng/ml. 95% of patients had near normal or mild increase (<0.5 ng/ml, only 5% of patients showed elevated levels. Notably, high PCT levels were found only in severe sepsis. Conclusion: PCT levels in Salmonella infections are near normal or minimally increased which differentiates it from other systemic Gram-negative infections. PCT cannot be used as a specific diagnostic marker of typhoid.

  2. PELOD score, serum procalcitonin, and lactate levels in pediatric sepsis

    Jufitriani Ismy

    2015-11-01

    Full Text Available Background Sepsis remains a major cause of morbidity and mortality among critically ill children in the pediatric intensive care unit (PICU. Procalcitonin and lactate have been used as biomarkers of sepsis, as they have been correlated with disease severity, organ failure and death. The Pediatric Logistic Organ Dysfunction (PELOD score is a tool to assess the severity of organ dysfunction in critically ill children. Objective To investigate the correlation between PELOD score and procalcitonin and lactate levels in pediatric sepsis. Methods A cross-sectional study was conducted in children with sepsis who were admitted to the PICU from April to July 2012. Sepsis was defined as systemic inflammatory response syndrome (SIRS, as a result of suspected or proven infection. Proven infection was defined as positive culture findings (blood, urine ot other specimens and/or serum procalcitonin >2 ng/mL. Spearman’s test was used to assess for correlations between PELOD scores and procalcitonin as well as lactate levels. Results Thirty-two patients were analyzed, consisting of 18 males and 14 females with an age range of 1-432 months (median 21 months. There was no statistically significant correlation between procalcitonin level and PELOD score (r=- 0.186, 95%CI -0.502 to 0.174, P=0.308 nor between lactate level(r=-0.069, 95%CI-0.408 to 0.287, P=0.709 and PELOD score. Conclusion Serum procalcitonin and lactate levels are not correlated with PELOD scores in children with sepsis.

  3. PELOD score, serum procalcitonin, and lactate levels in pediatric sepsis

    Jufitriani Ismy

    2016-11-01

    Full Text Available Background Sepsis remains a major cause of morbidity andmortality among critically ill children in the pediatric intensivecare unit (PICU. Procalcitonin and lactate have been used asbiomarkers of sepsis, as they have been correlated with diseaseseverity, organ failure and death. The Pediatric Logistic OrganDysfunction (PELOD score is a tool to assess the severity oforgan dysfunction in critically ill children.Objective To investigate the correlation between PELOD scoreand procalcitonin and lactate levels in pediatric sepsis.Methods A cross-sectional study was conducted in childrenwith sepsis who were admitted to the PICU from April to July2012. Sepsis was defined as systemic inflammatory responsesyndrome (SIRS, as a result of suspected or proven infection.Proven infection was defined as positive culture findings (blood, mL. Spearman’s test was used to assess for correlations betweenPELOD scores and procalcitonin as well as lactate levels.Results Thirty-two patients were analyzed, consisting of 18 malesand 14 females with an age range of 1-432 months (median 21months. There was no statistically significant correlation betweenprocalcitonin level and PELOD score (r=- 0.186, 95%CI -0.502to 0.174, P=0.308 nor between lactate level(r=-0.069, 95%CI-0.408 to 0.287, P=0.709 and PELOD score.Conclusion Serum procalcitonin and lactate levels are notcorrelated with PELOD scores in children with sepsis.

  4. The Procalcitonin And Survival Study (PASS – A Randomised multi-center investigator-initiated trial to investigate whether daily measurements biomarker Procalcitonin and pro-active diagnostic and therapeutic responses to abnormal Procalcitonin levels, can improve survival in intensive care unit patients. Calculated sample size (target population: 1000 patients

    Fjeldborg Paul

    2008-07-01

    Full Text Available Abstract Background Sepsis and complications to sepsis are major causes of mortality in critically ill patients. Rapid treatment of sepsis is of crucial importance for survival of patients. The infectious status of the critically ill patient is often difficult to assess because symptoms cannot be expressed and signs may present atypically. The established biological markers of inflammation (leucocytes, C-reactive protein may often be influenced by other parameters than infection, and may be unacceptably slowly released after progression of an infection. At the same time, lack of a relevant antimicrobial therapy in an early course of infection may be fatal for the patient. Specific and rapid markers of bacterial infection have been sought for use in these patients. Methods Multi-centre randomized controlled interventional trial. Powered for superiority and non-inferiority on all measured end points. Complies with, "Good Clinical Practice" (ICH-GCP Guideline (CPMP/ICH/135/95, Directive 2001/20/EC. Inclusion: 1 Age ≥ 18 years of age, 2 Admitted to the participating intensive care units, 3 Signed written informed consent. Exclusion: 1 Known hyper-bilirubinaemia. or hypertriglyceridaemia, 2 Likely that safety is compromised by blood sampling, 3 Pregnant or breast feeding. Computerized Randomisation: Two arms (1:1, n = 500 per arm: Arm 1: standard of care. Arm 2: standard of care and Procalcitonin guided diagnostics and treatment of infection. Primary Trial Objective: To address whether daily Procalcitonin measurements and immediate diagnostic and therapeutic response on day-to-day changes in procalcitonin can reduce the mortality of critically ill patients. Discussion For the first time ever, a mortality-endpoint, large scale randomized controlled trial with a biomarker-guided strategy compared to the best standard of care, is conducted in an Intensive care setting. Results will, with a high statistical power answer the question: Can the survival

  5. Procalcitonin Levels in Patients with Complete and Incomplete Kawasaki Disease

    Hwa Jin Cho

    2013-01-01

    Full Text Available Incomplete Kawasaki disease (iKD is considered to be a less complete form of Kawasaki disease (cKD, and several differences in the laboratory presentations of iKD and cKD have been noted. We investigated serum procalcitonin levels in patients with iKD, cKD, and other febrile diseases (a control group. Seventy-seven patients with cKD, 24 with iKD, and 41 controls admitted to our hospital from November 2009 to November 2011 were enrolled in the present study. We obtained four measurements of serum procalcitonin levels and those of other inflammatory markers from each patient. Samples were taken for analysis on the day of diagnosis (thus before treatment commenced; D0 and 2 (D2, 14 (D14, and 56 days (D56 after intravenous immunoglobulin infusion. We obtained control group data at D0. The mean D0 serum procalcitonin levels of cKD patients (0.71±1.36 ng/mL and controls (0.67±1.06 ng/mL were significantly higher than those of iKD patients (0.26±0.26 ng/mL (P=0.014 and P=0.041, resp.. No significant difference in mean procalcitonin level was evident among groups at any subsequent time. In conclusion, the serum procalcitonin level of patients with acute-stage cKD was significantly higher than that of iKD patients.

  6. Increased serum procalcitonin levels in pregnant patients with asymptomatic bacteriuria

    Bilir, Filiz; Akdemir, Nermin; Ozden, Selcuk; Cevrioglu, A Serhan; Bilir, Cemil

    2013-01-01

    Background Among the pregnancy urinary tract infections, asymptomatic bacteriuria (ASB) is the most common one. Untreated ASB can progress to pyelonephritis in 30-50% of the patients and can also result in prematurity in 27% of the pregnancy so it needs immediate diagnosis and treatment. In this study, we wanted to evaluate procalcitonin levels, compared to other inflammatory in pregnant women with ASB. Methods The study was designed between the period of January 2012 and February 2013 at Sak...

  7. Usefulness of Measuring Serum Procalcitonin Levels in Patients with Inflammatory Bowel Disease

    Chung, Sook Hee; Lee, Hye Won; Kim, Seung Won; Park, Soo Jung; Hong, Sung Pil; Kim, Tae Il; Kim, Won Ho; Cheon, Jae Hee

    2016-01-01

    Background/Aims The relationships between serum procalcitonin, inflammatory bowel disease (IBD) and intestinal Behçet’s disease (BD) have not been completely determined. We aimed to evaluate the usefulness of measuring serum procalcitonin levels to assess disease activity and infection stage in patients with IBD and intestinal BD. Methods We retrospectively analyzed clinical data from 129 patients with IBD and intestinal BD for whom serum procalcitonin and C-reactive protein (CRP) levels were...

  8. Serum Procalcitonine Levels as an Early Diagnostic Indicator of Sepsis

    Beqja-Lika, Anila; Bulo-Kasneci, Anyla; Refatllari, Etleva; Heta-Alliu, Nevila; Rucaj-Barbullushi, Alma; Mone, Iris; Mitre, Anila

    2013-01-01

    Introduction: Prompt and accurate diagnosis of sepsis is of high importance for clinicians. Procalcitonine (PCT) and C-reactive protein (CRP) have been proposed as markers for this purpose. Our aim was to evaluate the levels of PCT and CRP in early sepsis and its correlation with severity of sepsis. Methods: Levels of PCT and CRP were taken from 60 patients with sepsis criteria and 39 patients with SIRS symptoms from the University Hospital Center “Mother Teresa” in Tirana, Albania during 201...

  9. Serum procalcitonin and cerebrospinal fluid cytokines level in children with meningitis

    Erdal Taskın

    2004-01-01

    Full Text Available Aims: To determine the level of serum procalcitonin and cerebrospinal fluid cytokines in children with bacterial or viral meningitis and to document the use of these parameters in differential diagnosis.

  10. Early Serum Procalcitonin Level after Primary Total Hip Replacement

    Samy Bouaicha

    2013-01-01

    Full Text Available Background. Procalcitonin (PCT is a useful surrogate marker for the differentiation of postoperative infection and unspecific inflammatory reaction after surgery. It is known that postoperative course of the PCT serum level varies with type of surgery. No data exists about the postoperative course of serum PCT levels after primary total hip replacement (THR. Purpose. To characterize early postoperative serum PCT levels in uneventful primary THR compared to postoperative levels of different frequently used inflammatory blood parameters. Method. We prospectively investigated 31 patients. Blood samples were taken preoperatively and for 5 days postoperatively. PCT levels were compared with C-reactive protein (CRP, interleukin-6 (IL-6, and blood leucocyte counts (WBC. Results. In uneventful THR PCT levels showed a uniform low-level course with a peak at the second postoperative day. At the fifth day values returned to almost preoperative levels. On contrary, CRP levels remained high during the entire observational period. Only IL-6 levels showed a peak at postoperative day one with a quick and uniform return to preoperative levels. Conclusion. Similar to observations in cardiothoracic, intestinal, and neural surgeries, postoperative course of PCT after primary THR showed a uniform low-level course with a peak at the second postoperative day but below expected levels in systemic infections.

  11. Procalcitonin levels associate with severity of Clostridium difficile infection.

    Krishna Rao

    Full Text Available OBJECTIVE: Clostridium difficile infection (CDI is a major cause of morbidity and biomarkers that predict severity of illness are needed. Procalcitonin (PCT, a serum biomarker with specificity for bacterial infections, has been little studied in CDI. We hypothesized that PCT associated with CDI severity. DESIGN: Serum PCT levels were measured for 69 cases of CDI. Chart review was performed to evaluate the presence of severity markers and concurrent acute bacterial infection (CABI. We defined the binary variables clinical score as having fever (T >38°C, acute organ dysfunction (AOD, and/or WBC >15,000 cells/mm(3 and expanded score, which included the clinical score plus the following: ICU admission, no response to therapy, colectomy, and/or death. RESULTS: In univariate analysis log10 PCT associated with clinical score (OR 3.13, 95% CI 1.69-5.81, P0.2 ng/mL was 81% sensitive/73% specific for a positive clinical score and had a negative predictive value of 90%. CONCLUSION: An elevated PCT level associated with the presence of CDI severity markers and CDI was unlikely to be severe with a serum PCT level below 0.2 ng/mL. The extent to which PCT changes during CDI therapy or predicts recurrent CDI remains to be quantified.

  12. Plasma procalcitonin level as a predictor of treatment response in ICU patients with bacterial sepsis

    Mobaien AR

    2010-05-01

    Full Text Available "nBackground: Sepsis is one of the most important causes of mortality in severely ill ICU patients. At least, a part of high mortality rate in sepsis patients is due to less specific clinical symptoms for prompt diagnosis. Recently some studies report that serum levels of procalcitonin will increase in these patients but changes of serum levels following treatments is not known. This study was designed to determin procalcitonin levels in patients with bacterial infectious disease in ICU, initially and during therapy and compare the levels during response to treatment. "n"nMethods: This prospective cross-sectional study was conducted on ICU patients with infectious diseases, blood specimen collected on day 1 and then in days 3 and 7 of ICU admission. The semi-quantitative PCT-Q test was performed. "n"nResults: Thirty five patients, 22(62.9 % men and 13(37.1% women, were enrolled in this study. 18(51.4% patients died. Procalcitonin level in most patients in admission day was more than 10 ng/ml [16 (45.7%] but in patients that react to treatment, decline to lower than 0.5 ng/ml [14(77.8%]. Mean rank of procalcitonin level from 1.14 ng/ml in first day reached to 2.72 ng/ml in seventh day (p<0.0001. "n"nConclusions: This study showed that serum procalcitonin levels in ICU patients with bacterial sepsis significantly decrease following response to treatment. The measurement of serum procalcitonin in ICU patients with bacterial infectious diseases at first arrival day and following treatment is recommended.

  13. Role of serum procalcitonin level in early diagnosis of bacterial pneumonia in children, a hospital based study

    Sheikh Mohd Saleem; S. M. Salim Khan; Shah Sumaya Jan

    2016-01-01

    Background: Procalcitonin (PCT) is a precursor of hormone calcitonin. It is composed of 116 amino acids and is produced by para follicular C cells of the thyroid and by neuroendocrine cells of lungs and intestine. The level of Procalcitonin in healthy individuals is below the limit of detection (0.01 and micro;g/L).These levels may rise from extra thyroid tissues especially in response to inflammatory stimulus of bacterial origin. PCT has the greatest sensitivity and Specificity for different...

  14. Procalcitonin Levels Predict Clinical Course and Progression-Free Survival in Patients With Medullary Thyroid Cancer

    Walter, Martin A.; Meier, Christian; Radimerski, Tanja; Iten, Fabienne; Kraenzlin, Marius; Mueller-Brand, Jan; de Groot, Jan Willem B.; Kema, Ido P.; Links, Thera P.; Mueller, Beat

    2010-01-01

    BACKGROUND: Procalcitonin has been well established as an important marker of sepsis and systemic infection. The authors evaluated the diagnostic and predictive value of calcitonin and its prohormone procalcitonin in medullary thyroid cancer. METHODS: The authors systematically explored the ability

  15. Levels of procalcitonin, C-reactive protein and neopterin in patients with advanced HIV-1 infection

    P Bipath

    2012-06-01

    Full Text Available Objectives. To compare the value of procalcitonin, C-reactive protein (CRP and neopterin as indicators of immune deficiency, co-infection, efficacy of treatment, and disease progression, in patients with advanced HIV-1 infection. Design. Cross-sectional, investigating baseline blood measurements and clinical observations in 82 HIV-positive patients divided into an antiretroviral treatment (ART group and an ART-naïve group. Setting. Secondary general hospital in Pretoria. Results. Procalcitonin and CRP levels showed no significant differences between the ART and ART-naïve groups, and no correlations with CD4 counts or viral loads. CRP levels were significantly higher with TB co-infection (p<0.05. Neopterin levels were raised above normal in 92% of the ART-naïve group and in 75% of the ART group. The levels were significantly higher (p<0.05 in the ART- naïve group. Negative correlations were found between neopterin and CD4 counts for the total patient group (r=-0.482; p<0.001. Neopterin was significantly (p<0.05 higher in the HIV/TB co-infection group than in those without TB. Higher neopterin levels at baseline were associated with a decline in CD4 counts over the ensuing 6-month period, and patients with higher baseline neopterin levels developed more complications over the 6-month period. Conclusions. Compared with procalcitonin and CRP, neopterin appears to be associated with the degree of immunodeficiency and of co-infection with TB. Neopterin levels may be investigated further as a measure of disease progression or treatment response. S Afr J HIV Med 2012;13(2:78-82.

  16. Serum procalcitonin level in infectious and non- infectious systemic inflammatory response syndrome: a three- year study

    Ahmadinejad Z

    2010-01-01

    Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Sepsis is the leading cause of hospital admission and mortality. One marker for differentiation between infectious and non-infectious diseases is serum procalcitonin (PCT level. The goal of this study was evaluation of serum procalcitonin level for differentiation among infectious & non infectious systemic inflammatory response syndrome (SIRS."n"nMethods: In a cross sectional study 263 patients with probable symptoms of sepsis that admitted to emergency department of Imam Khomeini Hospital Complex in Tehran, Iran, between 2006 and 2008, were evaluated for serum procalcitonin level by semi quantitative method. The clinical findings, demographic and laboratory data were identified by reviewing the medical notes."n"nResults: A total of 263 patients enrolled in the study. Mean age in study patients was 46.9 year (±20.7 and most of the patients were male (65.8%. In 104 patients (39.5% serum procalcitonin level was less than 0.5 (ng/ml, in 49 patients (18.6% was between 0.5 and 2 (ng/ml, in 74 patients (28.1% was between 2 and 10 (ng/ml and in 36 patients (13.8% was more than 10 (ng/ml. Sixty three patients (60.6% with PCT<0.5ng/ml, had non-infectious SIRS, while all patients with PCT≥10ng/ml, had infectious

  17. Changes of serum procalcitonin (PCT) and IL-6 levels in patients with sepsis

    Objective: To investigate the importance of determination of changes of serum procalcitonin (PCT) and IL-6 levels in patients with sepsis. Methods: Serum PCT (with double-sandwich immunofluorescence assay) and IL-6 (with ELISA) levels were measured repeatedly in 130 patients with sepsis on d1, d3, d5, d7 after admission. Values in 130 healthy individuals were also measured as control. Results: The serum levels of PCT and IL-6 in the patients with sepsis of admission were significantly higher than those in controls. The levels dropped markedly in the survivors by d7. Among the septic patients, the levels in the succumbed patients were significantly higher those in the survivors (P<0.05). Conclusion: Serum PCT and IL-6 values appeared to be of prognostic value in patients with sepsis. (authors)

  18. Serum Neopterin and Procalcitonin Levels in Relationship with Pediatric Burn Wound Infections.

    Pilanci, Ozgur; Ergin, Sevgi; Sirekbasan, Serhat; Ersin, Idris; Habip, Zafer; Yuksel, Pelin; Kuvat, Nuray; Aslan, Mustafa; Dinc, Oyku; Saribas, Suat; Kocazeybek, Bekir

    2016-03-01

    Infection and septic complications in burn patients can be monitored by procalcitonin (PCT) and neopterin plasma values. The aim of the study was to investigate serum neopterin and PCT levels with WBC (white blood cell) and CRP (C-reactive protein) levels in patient group (PG) and healthy control group (HCG) and to investigate the relationship of these markers with burn wound infections (BWI). As the PG, 23 patients between 0-12 ages and up to 30% Total Body Surface Area (TBSA) burned and 15 HCG were included. PCT, neopterin, WBC, and CRP results on the first, the seventh, the fourteenth and the 21st day have been compared. During the follow-up period, 11 patients with BWI and 12 patients without BWI were classified as infected and non-infected patients, respectively. PCT and neopterin levels were detected higher in patients with BWI but no significant difference were present. Also, PCT and neopterin levels within the first 24 hours following the burn were detected higher in PG than HCG. CRP and WBC levels were detected high due to burn trauma. PCT and neopterin levels were increased in patients with BWI. PCT levels were increased during the pre-infectious period, while neopterin levels increased during the post-infectious period. PMID:27020868

  19. An Evaluation of Serum Procalcitonin and C-Reactive Protein Levels as Diagnostic and Prognostic Biomarkers of Severe Sepsis

    Szederjesi Janos

    2015-10-01

    Full Text Available Background: Recommendations have been made, following the multicenter Surviving Sepsis Campaign study, to standardize the definition of severe sepsis with reference to several parameters such as haemodynamic stability, acid-base balance, bilirubin, creatinine, International Normalized Ratio (INR, urine output and pulmonary functional value of the ratio between arterial oxigen partial pressure and inspiratory oxigen concentration. Procalcitonin (PCT is considered to be a gold standard biomarker for the inflammatory response, and recent studies have shown that it may help to discover whether a seriously ill person is developing sepsis. C-reactive protein (CRP is also used as a marker of inflammation in the body, as its blood levels increase if there is any inflammation in the body. The aim of this study was to evaluate serum procalcitonin and C-reactive protein levels as diagnostic and prognostic biomarkers of severe sepsis.

  20. Comparative Study of Plasma Endotoxin with Procalcitonin Levels in Diagnosis of Bacteremia in Intensive Care Unit Patients

    Tao Wang; Yun-Liang Cui; Zhao-Fen Lin; De-Chang Chen

    2016-01-01

    Background: Both procalcitonin (PCT) and plasma endotoxin levels cannot be solely used for a definite diagnosis of bacteremia or sepsis, and there has been few study comparing the values of the two biomarkers for the diagnosis of bacteremia. The aim of this study was to identify bacteria causing bacteremia and evaluate the role of the two biomarkers in the diagnosis of bacteremia in Intensive Care Unit (ICU). Methods: The medical records of 420 patients in ICU were retrospectively reviewed...

  1. Comparative Study of Plasma Endotoxin with Procalcitonin Levels in Diagnosis of Bacteremia in Intensive Care Unit Patients

    WANG, Tao; Cui, Yun-Liang; Lin, Zhao-fen; Chen, De-Chang

    2016-01-01

    Background: Both procalcitonin (PCT) and plasma endotoxin levels cannot be solely used for a definite diagnosis of bacteremia or sepsis, and there has been few study comparing the values of the two biomarkers for the diagnosis of bacteremia. The aim of this study was to identify bacteria causing bacteremia and evaluate the role of the two biomarkers in the diagnosis of bacteremia in Intensive Care Unit (ICU). Methods: The medical records of 420 patients in ICU were retrospectively reviewed. P...

  2. Comparison on Serum Levels of Procalcitonin of Children with Viral and Bacterial Infection

    2013-01-01

    Objective To compare and analyze serum levels of procalcitonin (PCT) of children with viral and bacterial infection and probe into the importance of determining the level of serum PCT in the diagnosis of bacterial infection in order to provide evidences of the clinical use of antibiotics. Methods A total of 85 cases of children with an average age of 8.9 years (10 months-12 years) were enrolled in this study, 53 cases were with viral infection and 32 cases with bacterial infection. We determined serum levels of PCT by semi-quantitative solid phase immunoassay, and the serum levels of PCT were divided into four grades as Results The serum level of PCT of the group with bacterial infection were signiifcantly higher than that of the group with viral infection (P Conclusions Serum PCT is a bacterial sensitive marker of bacterial infection in children, and the determination of the level of serum PCT is helpful for the diagnosis of bacterial infection, which can also be a basis for the use of antibiotics.

  3. Procalcitonin levels in acute exacerbation of COPD admitted in ICU: a prospective cohort study

    Daubin, Cédric; Parienti, Jean-Jacques; Vabret, Astrid; Ramakers, Michel; Fradin, Sabine; Terzi, Nicolas; Freymuth, François; Charbonneau, Pierre; du Cheyron, Damien

    2008-01-01

    Background Antibiotics are recommended for severe acute exacerbation of chronic obstructive pulmonary disease (AECOPD) admitted to intensive care units (ICU). Serum procalcitonin (PCT) could be a useful tool for selecting patients with a lower probability of developing bacterial infection, but its measurement has not been investigated in this population. Methods We conducted a single center prospective cohort study in consecutive COPD patients admitted to the ICU for AECOPD between September 2005 and September 2006. Sputum samples or tracheal aspirates were tested for the presence of bacteria and viruses. PCT levels were measured at the time of admittance, six hours, and 24 hours using a sensitive immunoassay. Results Thirty nine AECOPD patients were included, 31 of which (79%) required a ventilator support at admission. The median [25%–75% interquartile range] PCT level, assessed in 35/39 patients, was: 0.096 μg/L [IQR, 0.065 to 0.178] at the time of admission, 0.113 μg/L [IQR, 0.074 to 0.548] at six hours, and 0.137 μg/L [IQR, 0.088 to 0.252] at 24 hours. The highest PCT (PCTmax) levels were less than 0.1 μg/L in 14/35 (40%) patients and more than 0.25 μg/L in 10/35 (29%) patients, suggesting low and high probability of bacterial infection, respectively. Five species of bacteria and nine species of viruses were detected in 12/39 (31%) patients. Among the four patients positive for Pseudomonas aeruginosa, one had a PCTmax less than 0.25 μg/L and three had a PCTmax less than 0.1 μg/L. The one patient positive for Haemophilus influenzae had a PCTmax more than 0.25 μg/L. The presence or absence of viruses did not influence PCT at time of admission (0.068 vs 0.098 μg/L respectively, P = 0.80). Conclusion The likelihood of bacterial infection is low among COPD patients admitted to ICU for AECOPD (40% with PCT procalcitonin-based therapeutic strategy in critically ill COPD patients. PMID:18947382

  4. Procalcitonin in liver transplantation: are high levels due to donors or recipients?

    Eyraud, Daniel; Ben Ayed, Saïd; Tanguy, Marie Laure; Vézinet, Corinne; Siksik, Jean Michel; Bernard, Maguy; Fratéa, Sylvia; Movschin, Marie; Vaillant, Jean-Christophe; Coriat, Pierre; Hannoun, Laurent

    2008-01-01

    Introduction To date, a specific marker to evaluate and predict the clinical course or complication of the liver-transplanted patient is not available in clinical practice. Increased procalcitonin (PCT) levels have been found in infectious inflammation; poor organ perfusion and high PCT levels in the cardiac donor appeared to predict early graft failure. We evaluated PCT as a predictor of early graft dysfunction and postoperative complications. Methods PCT serum concentrations were measured in samples collected before organ retrieval from 67 consecutive brain-dead donors and in corresponding recipients from day 0, before liver transplantation, up to day 7 after liver transplantation. The following parameters were recorded in donors: amount of vasopressive drug doses, cardiac arrest history 24 hours before retrieval, number of days in the intensive care unit, age of donor, and infection in donor, and the following parameters were recorded in recipients: cold and warm ischemia time, veno-venous bypass, transfusion amount during orthotopic liver transplantation (OLT), and occurrence of postoperative complication or hepatic dysfunction. Results In the donor, the preoperative level of PCT was associated with cardiac arrest and high doses of catecholamines before organ retrieval. In the recipient, elevated PCT levels were observed early after OLT, with a peak at day 1 or 2 after OLT, then a decrease until day 7. A postoperative peak of PCT levels was associated neither with preoperative PCT levels in the donor or the recipients nor with hepatic post-OLT dysfunction or other postoperative complications, but with two donor parameters: infection and cardiac arrest. Conclusion PCT level in the donor and early PCT peak in the recipient are not predictive of post-OLT hepatic dysfunction or other complications. Cardiac arrest and infection in the donor, but not PCT level in the donor, are associated with high post-OLT PCT levels in the recipient. PMID:18601732

  5. Serum procalcitonin and CRP levels in non-alcoholic fatty liver disease: a case control study

    Ersoz Galip

    2009-02-01

    Full Text Available Abstract Background Both C reactive protein (CRP and procalcitonin (PCT are well known acute phase reactant proteins. CRP was reported to increase in metabolic syndrome and type-2 diabetes. Similarly altered level of serum PCT was found in chronic liver diseases and cirrhosis. The liver is considered the main source of CRP and a source of PCT, however, the serum PCT and CRP levels in non-alcoholic fatty liver disease (NAFLD were not compared previously. Therefore we aimed to study the diagnostic and discriminative role of serum PCT and CRP in NAFLD. Methods Fifty NAFLD cases and 50 healthy controls were included to the study. Liver function tests were measured, body mass index was calculated, and insulin resistance was determined by using a homeostasis model assessment (HOMA-IR. Ultrasound evaluation was performed for each subject. Serum CRP was measured with nephalometric method. Serum PCT was measured with Kryptor based system. Results Serum PCT levels were similar in steatohepatitis (n 20 and simple steatosis (n 27 patients, and were not different than the control group (0.06 ± 0.01, 0.04 ± 0.01 versus 0.06 ± 0.01 ng/ml respectively. Serum CRP levels were significantly higher in simple steatosis, and steatohepatitis groups compared to healthy controls (7.5 ± 1.6 and 5.2 ± 2.5 versus 2.9 ± 0.5 mg/dl respectively p Conclusion Serum PCT was within normal ranges in patients with simple steatosis or steatohepatitis and has no diagnostic value. Serum CRP level was increased in NAFLD compared to controls. CRP can be used as an additional marker for diagnosis of NAFLD but it has no value in discrimination of steatohepatitis from simple steatosis.

  6. Diagnostic and prognostic value of procalcitonin levels in patients with Bell's palsy.

    Kilicaslan, Saffet; Uluyol, Sinan; Gur, Mehmet Hafit; Arslan, Ilker Burak; Yagiz, Ozlem

    2016-06-01

    Inflammation is thought to play an important role in the pathogenesis of Bell's palsy (BP). Procalcitonin (PCT) is currently among the most frequently used proinflammatory biomarkers in clinical practice. In this study, we assessed the serum PCT levels for predicting the severity and prognosis of BP. In total, 32 patients with House-Brackmann (HB) grade II and III BP (low-grade group), 22 patients with HB grade IV and V (high-grade group) and 35 healthy individuals (control group) were included in this prospective study. PCT levels were compared among these three groups at the time of diagnosis. All patients received standard prednisolone and acyclovir treatment. The correlation between PCT levels and recovery was analyzed 3 months after treatment. The PCT levels for control, low-grade and high-grade BP groups were 0.01 ± 0.001, 0.35 ± 0.05, and 0.98 ± 0.41 ng/mL, respectively. The PCT level in low-grade group was significantly higher than that in control group (p < 0.001), and the PCT level in high-grade BP group was significantly higher than that in low-grade group (p = 0.01, p < 0.05). The complete recovery rate was 93.7 % in low-grade and 54.5 % in high-grade BP group (p = 0.015, p < 0.05). There was a strong negative correlation between PCT levels and recovery rates (r = -0.896, p < 0.001). PCT levels were significantly associated with the severity of BP and higher PCT levels were related with poor clinical outcome in terms of recovery. These results support the diagnostic and prognostic significance of PCT in patients with early BP. PMID:26894418

  7. HIGH BLOOD LEVELS PROCALCITONIN AS SYSTEMIC IMFLAMATORY RESPONSE SYNDROME PREDICTOR IN SEVERE AND MODERATE HEAD INJURY

    B. Sinaga

    2014-01-01

    Full Text Available BackgroundNumerous studies have shown that procalcitonin (PCT was not related to degree of trauma. High PCT serum levels have been found in patients with bacterial or fungal infection and also in acute phase of trauma. Currently, there has been no research discussed about changes in serum levels of PCT in particular head injuries and severe head injuries. Moderate and severe head injuries were common trauma cases in Emergency Room (ER and had high mortality rate. Based on Glasgow Coma Scale (GCS, moderate and severe head injuries were scored between 3 and 13. This research aim to determine whether high blood levels PCT can be used as a predictor of the occurrence of SIRS. Method: A cohort prospective study was applied in this research to determine high blood levels of PCT as a predictor for SIRS in moderate and severe head injury. This study was conducted from June 2013 - August 2013 at Sanglah General Hospital with 40 research subjects. Data was presented in tables and analyzed with Chi Square test at 95% CI and p <0.05% was considered significant. Results: From the 40 samples, there were 34 males (85% and 6 females (15%, 18 samples (45% had moderate head injury and 22 samples (65% had severe head injury. One sample (2.5 % was 0-10 years old, 15 samples (37.5% were 10-20 years old, 13 samples (32.5% were 20-40 years old, 7 samples (17.5% were 40-60 years old and 4 samples (10% were>60 years old. PCT levels in the blood obtained on day first were normal in 6 samples (15% and elevated in 34 samples (85%, SIRS (+ were found in 35 samples (87.5% and 5 samples (12.5% were SIRS (-. Using bivariate analysis between PCT levels and SIRS showed p = 0.000 (p < 0.05, and multivariate analysis of the control variables showed no significant correlation between variables with PCT levels. Conclusion: From 40 samples moderate head injury and severe head injury, there were 34 samples (85% with elevated PCT level on the first day, while 35 samples (87.5% had SIRS

  8. Procalcitonin levels predict acute kidney injury and prognosis in acute pancreatitis: a prospective study.

    Hua-Lan Huang

    Full Text Available BACKGROUND: Acute kidney injury (AKI has been proposed as a leading cause of mortality for acute pancreatitis (AP patients admitted to the intensive care unit (ICU. This study investigated the predictive value of procalcitonin (PCT for AKI development and relevant prognosis in patients with AP, and compared PCT's predictive power with that of other inflammation-related variables. METHODS: Between January 2011 and March 2013, we enrolled 305 cases with acute pancreatitis admitted to ICU. Serum levels of PCT, serum amyloid A (SAA, interleukin-6 (IL-6, and C reactive protein (CRP were determined on admission. Serum PCT was tested in patients who developed AKI on the day of AKI occurrence and on either day 28 after occurrence (for survivors or on the day of death (for those who died within 28 days. RESULTS: Serum PCT levels were 100-fold higher in the AKI group than in the non-AKI group on the day of ICU admission (p<0.05. The area under the receiver-operating characteristic (ROC curve of PCT for predicting AKI was 0.986, which was superior to SAA, CRP, and IL-6 (p<0.05. ROC analysis revealed all variables tested had lower predictive performance for AKI prognosis. The average serum PCT level on day 28 (2.67 (0.89, 7.99 ng/ml was significantly (p<0.0001 lower than on the day of AKI occurrence (43.71 (19.24,65.69 ng/ml in survivors, but the serum PCT level on death (63.73 (34.22,94.30 ng/ml was higher than on the day of AKI occurrence (37.55 (18.70,74.12 ng/ml in non-survivors, although there was no significant difference between the two days in the latter group (p = 0.1365. CONCLUSION: Serum PCT is superior to CRP, IL-6, and SAA for predicting the development of AKI in patients with AP, and also can be used for dynamic evaluation of AKI prognosis.

  9. Evaluation of procalcitonin and neopterin level in serum of patients with acute bacterial infection

    Babak Pourakbari; Setareh Mamishi; Javid Zafari; Hanieh Khairkhah; Mohammad H Ashtiani; Masomeh Abedini; Shahla Afsharpaiman; Soroush Seifi Rad

    2010-01-01

    BACKGROUND: Fever as a common presenting complaint in pediatric patients can be due to various causes. Differentiating bacterial infection from other causes is important because the prompt use of antibiotics is critical in bacterial infection. Traditional markers of infection such as BT and WBC count may be unspecific and culture may be late or absent. CRP and Procalcitonin (PCT) have been considered to evaluate the evolution of infections and sepsis in patients presenting with SIRS. Neopteri...

  10. Procalcitonin levels in acute exacerbation of COPD admitted in ICU: a prospective cohort study

    Freymuth François

    2008-10-01

    Full Text Available Abstract Background Antibiotics are recommended for severe acute exacerbation of chronic obstructive pulmonary disease (AECOPD admitted to intensive care units (ICU. Serum procalcitonin (PCT could be a useful tool for selecting patients with a lower probability of developing bacterial infection, but its measurement has not been investigated in this population. Methods We conducted a single center prospective cohort study in consecutive COPD patients admitted to the ICU for AECOPD between September 2005 and September 2006. Sputum samples or tracheal aspirates were tested for the presence of bacteria and viruses. PCT levels were measured at the time of admittance, six hours, and 24 hours using a sensitive immunoassay. Results Thirty nine AECOPD patients were included, 31 of which (79% required a ventilator support at admission. The median [25%–75% interquartile range] PCT level, assessed in 35/39 patients, was: 0.096 μg/L [IQR, 0.065 to 0.178] at the time of admission, 0.113 μg/L [IQR, 0.074 to 0.548] at six hours, and 0.137 μg/L [IQR, 0.088 to 0.252] at 24 hours. The highest PCT (PCTmax levels were less than 0.1 μg/L in 14/35 (40% patients and more than 0.25 μg/L in 10/35 (29% patients, suggesting low and high probability of bacterial infection, respectively. Five species of bacteria and nine species of viruses were detected in 12/39 (31% patients. Among the four patients positive for Pseudomonas aeruginosa, one had a PCTmax less than 0.25 μg/L and three had a PCTmax less than 0.1 μg/L. The one patient positive for Haemophilus influenzae had a PCTmax more than 0.25 μg/L. The presence or absence of viruses did not influence PCT at time of admission (0.068 vs 0.098 μg/L respectively, P = 0.80. Conclusion The likelihood of bacterial infection is low among COPD patients admitted to ICU for AECOPD (40% with PCT

  11. Medical Costs of Abnormal Serum Sodium Levels

    Shea, Alisa M.; Hammill, Bradley G.; Curtis, Lesley H.; Szczech, Lynda A.; Schulman, Kevin A

    2008-01-01

    An abnormal serum sodium level is the most common electrolyte disorder in the United States and can have a significant impact on morbidity and mortality. The direct medical costs of abnormal serum sodium levels are not well understood. The impact of hyponatremia and hypernatremia on 6-mo and 1-yr direct medical costs was examined by analyzing data from the Integrated HealthCare Information Services National Managed Care Benchmark Database. During the period analyzed, there were 1274 patients ...

  12. Procalcitonin as an indicator of urosepsis

    Sugimoto K

    2013-03-01

    Full Text Available Koichi Sugimoto, Shogo Adomi, Hiroyuki Koike, Atsunobu Esa Department of Urology, NTT West Osaka Hospital, Osaka, Japan Background: Procalcitonin has been advocated as a marker of bacterial infection, so this study was carried out to determine the usefulness of serum procalcitonin in the early diagnosis of urosepsis. Methods: The subjects were 37 febrile patients with urinary tract infection in whom we examined the serum procalcitonin concentration at the start of treatment. Results: Thirty patients had acute pyelonephritis (16 simple, 14 complex, one had emphysematous pyelonephritis, five had acute prostatitis, and one had acute epididymitis. The procalcitonin level was <0.5 ng/mL in 18 patients, ≥0.5 ng/mL in one patient, ≥2 ng/mL in seven patients, and ≥10 ng/mL in 11 patients. Five of the 11 patients with procalcitonin levels ≥ 10 ng/mL had disseminated intravascular coagulation. All patients with urinary tract obstruction and disseminated intravascular coagulation had procalcitonin levels ≥ 10 ng/mL. Conclusion: Although this retrospective study comprised a small number of patients, we found that procalcitonin was a useful marker for urinary tract infection. Keywords: procalcitonin, urosepsis, urinary tract infection, urology

  13. The potential of molecular diagnostics and serum procalcitonin levels to change the antibiotic management of community-acquired pneumonia.

    Gilbert, David; Gelfer, Gita; Wang, Lian; Myers, Jillian; Bajema, Kristina; Johnston, Michael; Leggett, James

    2016-09-01

    Two diagnostic bundles were compared in 127 evaluable patients admitted with community-acquired pneumonia (CAP). Diagnostic modalities in all patients included cultures of sputum (if obtainable) and blood, urine for detection of the antigens of Streptococcus pneumoniae and Legionella pneumophila, and nasal swabs for PCR probes for S. pneumoniae and Staphylococcus aureus. At least one procalcitonin level was measured in all patients. For virus detection, patients were randomized to either a 5-virus, lab-generated PCR panel or the broader and faster FilmArray PCR panel. Overall, an etiologic diagnosis was established in 71% of the patients. A respiratory virus was detected in 39%. The potential for improved antibiotic stewardship was evident in 25 patients with only detectable respiratory virus and normal levels of PCT. PMID:27377675

  14. PROCALCITONIN AS A MARKER FOR EARLY DIAGNOSIS OF SEPSIS

    Rahim Raoofi

    2014-01-01

    Full Text Available Sepsis is a critical condition often caused by bacterial infection and associated with death and mortality. The prognosis of this disease depends on early diagnosis and proper treatment. Definite diagnosis of sepsis is positive blood culture and this test needs a long time to perform, so other biochemical parameters such as procalcitonin serum level has been introduced. To determine sensitivity, specificity, positive and negative predictive value of procalcitonin serum level at first time and 72 h after admission and to compare it with blood culture test for diagnosis of sepsis. Blood sample for blood culture, prepheral blood smear at first time and procalcitonin serum level measuring by semi quantitative method at first and 72 h after admission were sampled. Nine patients had positive blood cultures. Peripheral blood smear was positive in 38 patients, (29 patients: gram stain positive, 6 patients: gram stain negative and 3 patients: both gram positive and gram negative. At first time 76.8% had positive procalcitonin (>0.5 ng mL-1 and after 72 h 65% of patients had positive procalcitonin. Sensitivity, specificity, positive and negative predictive value of procalcitonin at the first time were 100, 16,16 and 100% and for procalcitonin after 72 h respectively were 75, 35, 15 and 90%. This study showed that sensitivity of procalcitonin serum level can be used for diagnosis of sepsis. Procalcitonin increased as severity of sepsis and this study suggests high serum level of procalcitonin after 72 h might indicate poor outcome.

  15. Determination of Procalcitonin Levels in Patients with Nephropathia Epidemica - A Useful Tool or an Unnecessary Diagnostic Procedure?

    Joerg Latus

    2015-01-01

    Full Text Available Background/Aims: Puumala virus causes nephropathia epidemica (NE, a milder form of hemorrhagic fever with renal syndrome that occurs in Central and Northern Europe. Several studies have sought to identify risk factors for severe NE. However, elevated procalcitonin (PCT levels have not previously been investigated as a predictive marker for a severe course of NE. Methods: A cross-sectional prospective survey of 456 adults with serologically confirmed NE was performed. Results: PCT levels at the time of diagnosis were available for 43 out of 456 patients, and in 24 of these patients (56% PCT levels were elevated (“PCT positive”. C-reactive protein (CRP levels at admission to hospital and peak CRP levels during the acute course of the disease were higher in the PCT-positive compared with the PCT-negative group (pConclusions: Elevated PCT levels are common in patients with acute NE. There was no association between PCT levels and severity of disease, including AKI or thrombocytopenia. It is important to distinguish Puumala virus infection from other causes of AKI with thrombocytopenia. However, PCT might not be useful in differentiating hantavirus infection from bacterial infection.

  16. Comparative Study of Plasma Endotoxin with Procalcitonin Levels in Diagnosis of Bacteremia in Intensive Care Unit Patients

    Tao Wang; Yun-Liang Cui; Zhao-Fen Lin; De-Chang Chen

    2016-01-01

    Background: Both procalcitonin (PCT) and plasma endotoxin levels cannot be solely used for a definite diagnosis ofbacteremia or sepsis, and there has been few study comparing the values of the two biomarkers for the diagnosis of bacteremia.The aim of this study was to identify bacteria causing bacteremia and evaluate the role of the two biomarkers in the diagnosis ofbacteremia in Intensive Care Unit (ICU).Methods: The medical records of 420 patients in ICU were retrospectively reviewed.Patients (n =241) who met the inclusion criteria were subjected to blood culture (BC) for the analysis of the endotoxin or PCT levels.The exclusion criteria included the presence of infection with human immunodeficiency virus and/or AIDS, neutropenia without sepsis, pregnancy, treatment with immunosuppressive therapies, or blood diseases such as hematological tumors.Patients' BC episodes were divided into BC negative, Gram-negative (GN) bacteria, Gram-positive bacteria, and fungi groups.The PCT and plasma endotoxin levels were compared in the different groups.Results: A total of 241 patients with 505 episodes of BC were analyzed.The GN bacteria group showed higher levels of PCT and endotoxin than the BC negative, Gram-positive bacteria, and fungi groups.GN bacteremia was more prevalent than Gram-positive bacteremia.The GN bacteremia caused by non-Enterobacteriaceae infection presented higher endotoxin level than that by Enterobacteriaceae, but no significant difference in PCT levels was observed between the two groups.The plasma endotoxin significantly differed among different groups and was bacterial species dependent.Conclusions: Plasma endotoxin was more related to GN than to Gram-positive bacteremia, and that endotoxin level was species dependent, but PCT level remained relatively more stable within the GN bacteria caused bacteremia.Both GN and positive bacteria caused bacteremia in the ICU patients in different regions of China.And PCT is a more valuable biomarker than endotoxin

  17. Comparative Study of Plasma Endotoxin with Procalcitonin Levels in Diagnosis of Bacteremia in Intensive Care Unit Patients

    Wang, Tao; Cui, Yun-Liang; Lin, Zhao-Fen; Chen, De-Chang

    2016-01-01

    Background: Both procalcitonin (PCT) and plasma endotoxin levels cannot be solely used for a definite diagnosis of bacteremia or sepsis, and there has been few study comparing the values of the two biomarkers for the diagnosis of bacteremia. The aim of this study was to identify bacteria causing bacteremia and evaluate the role of the two biomarkers in the diagnosis of bacteremia in Intensive Care Unit (ICU). Methods: The medical records of 420 patients in ICU were retrospectively reviewed. Patients (n = 241) who met the inclusion criteria were subjected to blood culture (BC) for the analysis of the endotoxin or PCT levels. The exclusion criteria included the presence of infection with human immunodeficiency virus and/or AIDS, neutropenia without sepsis, pregnancy, treatment with immunosuppressive therapies, or blood diseases such as hematological tumors. Patients’ BC episodes were divided into BC negative, Gram-negative (GN) bacteria, Gram-positive bacteria, and fungi groups. The PCT and plasma endotoxin levels were compared in the different groups. Results: A total of 241 patients with 505 episodes of BC were analyzed. The GN bacteria group showed higher levels of PCT and endotoxin than the BC negative, Gram-positive bacteria, and fungi groups. GN bacteremia was more prevalent than Gram-positive bacteremia. The GN bacteremia caused by non-Enterobacteriaceae infection presented higher endotoxin level than that by Enterobacteriaceae, but no significant difference in PCT levels was observed between the two groups. The plasma endotoxin significantly differed among different groups and was bacterial species dependent. Conclusions: Plasma endotoxin was more related to GN than to Gram-positive bacteremia, and that endotoxin level was species dependent, but PCT level remained relatively more stable within the GN bacteria caused bacteremia. Both GN and positive bacteria caused bacteremia in the ICU patients in different regions of China. And PCT is a more valuable

  18. Evolution of procalcitonin, C-reactive protein and fibrinogen levels in neutropenic leukaemia patients with invasive pulmonary aspergillosis or mucormycosis.

    Roques, Marjorie; Chretien, Marie Lorraine; Favennec, Camille; Lafon, Ingrid; Ferrant, Emmanuelle; Legouge, Caroline; Plocque, Alexia; Golfier, Camille; Duvillard, Laurence; Amoureux, Lucie; Bastie, Jean Noel; Maurin-Bernier, Lory; Dalle, Frederic; Caillot, Denis

    2016-06-01

    Unlike bacterial infections, the value of procalcitonin (PCT) in detecting fungal infections in leukaemia patients is not clear. To determine whether the monitoring of PCT coupled with C-reactive protein (CRP) and fibrinogen (Fib) could be helpful in the management of pulmonary aspergillosis (IPA) or mucormycosis (PM), we retrospectively analysed the evolution of PCT, CRP and Fib levels in 94 leukaemia patients with proven/probable IPA (n = 77) or PM (n = 17) from D-12 to D12 relative to IFI onset defined as D0. Overall, 2140 assays were performed. From D-12 to D0, 12%, 5% and 1.4% of patients had PCT >0.5, 1 and 1.5 μg l(-1) , respectively, while CRP was >50, 75 and 100 mg l(-1) in 84%, 70% and 57% and Fib was >4, 5 and 6 g l(-1) in 96%, 80% and 61% of cases respectively (P 1.5 μg l(-1) , while CRP >100 mg l(-1) and Fib >6 g l(-1) were observed in 80% and 75% of cases respectively (P < 10(-7) ). In leukaemia patients, IPA or PM was accompanied by a significant increase in CRP and Fib while PCT remained low. PMID:26931315

  19. Differential kinetics of plasma procalcitonin levels in cerebral malaria in urban Senegalese patients according to disease outcome

    Babacar Mbengue

    2011-11-01

    Full Text Available P. falciparum malaria continues as the serial killer of over a million lives yearly, mainly for children in sub-Saharan Africa. For severe malaria, we are still on the quest for a prognostic marker of fatal outcome. We analysed the association between serum levels of Procalcitonin (PCT, a marker of septic inflammation, and clinical outcome in Senegalese patients admitted with confirmed cerebral malaria in the intensive care facility of Hopital Principal. A total of 98 patients living in the hypoendemic urban area of Dakar, Senegal, were enrolled during transmission seasons. Levels of PCT were compared between surviving vs the 26.5 % fatal cases in blood samples of the 3 days following hospitalisation. Mean PCT levels were elevated in patients with active infection, with a large range of values (0.1 to 280 nanog per mL, significantly higher on day 0 in fatal cases than in surviving (53.6 vs 27.3; P=0.01. No exact individual threshold level could indicate occurrence of fatality, however mortality could be most accurately predicted by PCT level above 69 nanog per ML and there was a very clear different profile of evolution of PCT levels on the 3 days of observation decreasing early from day 1 in surviving patients (P<10–3, contrary to fatal cases. These results indicate that PCT kinetic rather than intrinsic level could be of use to predict a reduced risk of fatality in patient with cerebral malaria and could serve as potential predicting marker for severe malaria.

  20. Procalcitonin as a marker of neonatal sepsis

    Nazeer Ahmad Jeergal; Rizwan-u-zama; Naushad Ali .N. Malagi; Faisal Farooqui; Sadashiva .B. Ukkali; Ravindra Naganoor; A.N. Thobbi

    2016-01-01

    Introduction: Neonatal sepsis is one of the commonest causes of neonatal mortality in the developing world. Procalcitonin (PCT) has emerged as the most studied and promising sepsis biomarker. Objective: To assess the role of procalcitonin (PCT) as a marker in the early diagnosis, treatment and follow-up of neonatal sepsis. Methods: Twenty five neonates with clinical (n=5), suspected (n=13) and proven sepsis (n=7) were evaluated. The PCT levels were measured by immunoluminoassay before and on ...

  1. Procalcitonin in liver transplant patients--yet another stone turned

    Jensen, Jens-Ulrik; Lundgren, Jens D

    2008-01-01

    Liver transplantation has been reported to initiate increases in procalcitonin levels, in the absence of bacterial infection. The results of a study investigating the course of procalcitonin levels over several days after liver transplantation in noninfected patients were recently reported in...... undergoing liver transplantation with and without bacterial infection are needed....

  2. Diagnostic value of serum procalcitonin levels in children with meningitis: a comparison with blood leukocyte count and C-reactive protein

    Objectives: To determine the level of serum procalcitonin, blood leukocyte count (TLC) and C-reactive protein (CRP) in children with bacterial and non bacterial meningitis and document their efficacy in differential diagnosis. Also described are procalcitonin levels variation during treatment. Methods: From March 2005 to February 2008, we evaluated 38 clinically suspected meningitis patients in the paediatric departments, Al-Jedaany Hospital, Jeddah, KSA, for Serum procalcitonin, CRP, TLC and Lumbar punctures and CSF analysis. Patients were classified into bacterial meningitis group I (18) and non bacterial meningitis group II (20). Results: Serum PCT levels were significantly higher in bacterial meningitis (BM) 9 mean 4.8 +- 3.85 ng/ml (2.9-11.6)) compared with non bacterial meningitis (NBM) (mean 0.38 +- 0.25 ng/ml(0.31-0.61)) P< 0.001). Mean of all CSF parameters, TLC (15,000 +- 2,900 cell/ml(BM) and 9,500 +-1,105 cell/ml(NBM))and CRP (20 +- 6.8 mg/l (BM) and 12.5 +-12.0 mg/l(NBM))showed a zone of overlapping between the two groups. There is a positive correlation between serum PCT, TLC and CRP in bacterial and non bacterial meningitis cases but this relation becomes highly significant with bacterial meningitis positive group. Day 3 and day 6 treatment serum PCT was less than on admission levels (P<0.001). Conclusion: PCT can be used in the early diagnosis of bacterial meningitis and may be a useful adjunct in differentiating bacterial and non bacterial meningitis than CRP or TLC and diminishing the value of lumbar puncture performed 48-72 hours after admission to assess treatment efficacy. (author)

  3. Serum procalcitonin and interleukin-6 levels may help to differentiate systemic inflammatory response of infectious and non-infectious origin

    杜斌; 潘家绮; 陈德昌; 李毅

    2003-01-01

    Objective To evaluate the efficacy of using procalcitonin (PCT) and interleukin-6 (IL-6) to differentiate sepsis from non-infectious systemic inflammatory response syndrome (SIRS). Methods We made a prospective study in a general intensive care unit at Peking Union Medical College Hospital. Twenty patients with sepsis and 31 patients with non-infectious SIRS were enrolled in this study. Serum concentrations of PCT, IL-6 and C-reactive protein (CRP) were determined within 24 h after clinical onset of sepsis or non-infectious SIRS. Leukocyte count, percentage of neutrophils, and absolute neutrophil count, as well as maximal body temperature were also recorded.Results Serum concentrations of PCT, IL-6, and CRP, as well as maximal body temperature, were significantly higher in septic patients [3.6 (1.8, 27.5) μg/L, 810±516 ng/L, 180±108 g/L, 38.6±1.2℃] than non-infectious SIRS patients [0.5 (0.2, 1.8) μg/L, 235±177 ng/L, 109±70 g/L, 37.9±0.9℃]. IL-6 and PCT exhibited the best discriminative power between sepsis and non-infectious SIRS, with sensitivity above 80% and specificity above 70%. A sepsis score with combination of IL-6 and PCT showed the best discriminative power with the area under the receiver operating characteristic curve of 0.923.Conclusions Assessing IL-6 and PCT levels are more reliable ways to differentiate sepsis from non-infectious SIRS, compared with conventional inflammatory parameters.

  4. [Proper usage of procalcitonin].

    Green, Y; Petignat, P-A; Perrier, A

    2007-10-17

    In the last fifteen years, procalcitonin measurement has been evaluated as a rapid diagnostic aid for suspected infection. Procalcitonin is now widely used in any febrile patient despite the lack of evidence supporting that practice. Indeed, procalcitonine has proven effective in the intensive care setting, as a diagnostic aid for septic shock, as a prognostic instrument and to tailor the duration of antibiotic treatment. Studies in non intensive care settings are more recent and scarce. Procalcitonin has been assessed in the emergency department in patients with lower respiratory tract infections and in patients admitted for an acute febrile illness. Results are encouraging but preliminary, therefore procalcitonine measurement should be restricted to patients with criteria of severe infection for the time being. PMID:18018823

  5. PROCALCITONIN AS A MARKER FOR EARLY DIAGNOSIS OF SEPSIS

    Rahim Raoofi; Zahra Salmani; Fatemh Moradi; Abdolrerza Sotoodeh; Saeed Sobhanian

    2014-01-01

    Sepsis is a critical condition often caused by bacterial infection and associated with death and mortality. The prognosis of this disease depends on early diagnosis and proper treatment. Definite diagnosis of sepsis is positive blood culture and this test needs a long time to perform, so other biochemical parameters such as procalcitonin serum level has been introduced. To determine sensitivity, specificity, positive and negative predictive value of procalcitonin serum level at first time and...

  6. Diagnostic value of procalcitonin for acute complicated appendicitis

    Yamashita, Hiromasa; YUASA, NORIHIRO; TAKEUCHI, EIJI; Goto, Yasutomo; Miyake, Hideo; Miyata, Kanji; Kato, Hideki; Ito, Masafumi

    2016-01-01

    ABSTRACT A rapid and reliable test for detection of complicated appendicitis would be useful when deciding whether emergency surgery is required. We investigated the clinical usefulness of procalcitonin for identifying acute complicated appendicitis. We retrospectively analyzed 63 patients aged ≥15 years who underwent appendectomy without receiving antibiotics before admission and had preoperative data on the plasma procalcitonin level (PCT), body temperature (BT), white blood cell count (WBC...

  7. The role of procalcitonin in adult patients with community-acquired pneumonia--a systematic review

    Berg, Peter; Lindhardt, Bjarne Ørskov

    2012-01-01

    Promising results in relation to severity assessment and treatment of patients with community-acquired pneumonia (CAP) have recently been presented from the study of procalcitonin (PCT) levels in these patients.......Promising results in relation to severity assessment and treatment of patients with community-acquired pneumonia (CAP) have recently been presented from the study of procalcitonin (PCT) levels in these patients....

  8. Procalcitonin increase in early identification of critically ill patients at high risk of mortality

    Jensen, Jens Ulrik; Heslet, Lars; Jensen, Tom Hartvig;

    2006-01-01

    To investigate day-by-day changes in procalcitonin and maximum obtained levels as predictors of mortality in critically ill patients.......To investigate day-by-day changes in procalcitonin and maximum obtained levels as predictors of mortality in critically ill patients....

  9. 血清降钙素原在胆道感染中的诊断价值%Clinical application of serum procalcitonin level in diagnosing biliary tract infection

    李惠; 高堃; 翟仁友; 戴定可; 黄强; 王剑锋

    2013-01-01

    Objective To discuss the clinical value of serum procalcitonin level in diagnosing biliary tract infection. Methods A total of 53 patients with obstructive jaundice were enrolled in this study. The serum procalcitonin level was determined in all patients by immunolofluoreseence sandwich method. Percutanous biliary drainage was performed in all patients. Based on the bile culture result and the clinical manifestations, the patients were divided into the bacterial infection group (n = 33) and the non-bacterial infection group (n = 20). The serum procalcitonin level, white blood cell (WBC) count and the percentage of neutrophilic granulocyte were determined, and the results were compared between the two groups. Results Taking 0.25 ng/ml as the positive threshold of serum procalcitonin level, the sensitivity and the specificity for the diagnosis of biliary tract bacterial infection were 91.9% and 87.5% respectively. When WBC of 8.89 × 109/L was taken as the positive threshold, the sensitivity and the specificity for the diagnosis of biliary tract bacterial infection were 54.8% and 83.3% respectively. If neutrophilic granulocyte of 74.25% was regarded as the positive threshold, the sensitivity and the specificity for the diagnosis of biliary tract bacterial infection were 66.1% and 70.8% respectively. The serum procalcitonin level in the bacterial infection group was significantly higher than that in the non-bacterial infection group (P < 0.05). Conclusion Determination of serum procalcitonin level is very helpful for the diagnosis of biliary tract bacterial infection with much higher sensitivity and specificity. Therefore, serum procalcitonin level can be used as an effective index for biliary tract bacterial infection.%目的 探讨血清降钙素原(PCT)浓度在胆道感染中的诊断价值.方法 采用荧光免疫夹心法检测53例梗阻性黄疸患者血清PCT浓度,所有患者均行经皮经肝穿刺胆管引流术,根据胆汁培养结果及临床症状

  10. Procalcitonin for detecting community-acquired bacterial pneumonia

    Devi Gusmaiyanto

    2015-03-01

    Full Text Available Background Pneumonia is a major cause of morbidity and mortality in children under five years of age. Pneumonia can be of bacterial or viral origin. It is difficult to distinguish between these two agents based on clinical manifestations, as well as radiological and laboratory examinations. Furthermore, bacterial cultures take time to incubate and positive results may only be found in 10-30% of bacterial pneumonia cases. Procalcitonin has been used as a marker to distinguish etiologies, as bacterial infections tend to increase serum procalcitonin levels. Objective To determine the sensitivity, specificity, positive predictive value and negative predictive value of procalcitonin in community-acquired bacterial pneumonia. Method This cross-sectional study was conducted in the Pediatric Health Department of Dr. M. Djamil Hospital, Padang. Subjects were selected by consecutive sampling. Procalcitonin measurements and PCR screening were performed on blood specimens from 32 pneumonia patients and compared. Results Of the 32 subjects, most were boys (56.25%, under 5 years of age (99%, and had poor nutritional status (68.75%. Using a cut-off point of 0.25 ng/mL, procalcitonin level had a sensitivity of 92%, specificity 50%, positive predictive value 88%, and negative predictive value 60% for diagnosing bacterial pneumonia. Using a cut-off point of 0.5 ng/mL, procalcitonin level had a specificity of 46%, specificity 83%, positive predictive value 91%, and negative predictive value 25%. Conclusion A cut-off point of 0.25 ng/mL of procalcitonin level may be more useful to screen for bacterial pneumonia than a cut-off point of 0.5 ng / mL. However, if the 0.25 ng/mL cut-off point is used, careful monitoring will be required for negative results, as up to 40% may actually have bacterial pneumonia. [Paediatr Indones. 2015;55:65-9.].

  11. Plasma Procalcitonin Is Associated with Obesity, Insulin Resistance, and the Metabolic Syndrome

    Abbasi, Ali; Corpeleijn, Eva; Postmus, Douwe; Gansevoort, Ron T.; de Jong, Paul E.; Gans, Rijk O. B.; Struck, Joachim; Hillege, Hans L.; Stolk, Ronald P.; Navis, Gerjan; Bakker, Stephan J. L.

    2010-01-01

    Context: Procalcitonin, a well-known biomarker of sepsis and bacterial infections, is produced by adipose tissue and has potential as a marker for chronic low-grade inflammation. Objectives: The objective of this study was to investigate whether plasma procalcitonin levels in the normal range are as

  12. Prognostic value of serum procalcitonin and C-reactive protein levels in critically ill patients who developed ventilator-associated pneumonia

    Hakan Tanriverdi

    2015-01-01

    Full Text Available INTRODUCTION: Ventilator-associated pneumonia (VAP is an important cause of mortality and morbidity in critically ill patients. We sought to determine the prognostic value of procalcitonin (PCT and C-reactive protein (CRP kinetics in critically ill patients who developed VAP. METHODS: Patients who were admitted to the intensive care unit (ICU and developed VAP were eligible. Patients were followed for 28 days after the pneumonia diagnosis and blood samples for PCT and CRP were collected on the day of the pneumonia diagnosis (D0, and days 3 (D3 and 7 (D7 after the diagnosis. Patients were grouped as survivors and non-survivors, and the mean PCT and CRP values and their kinetics were assessed. RESULTS: In total, 45 patients were enrolled. Of them, 22 (48.8% died before day 28 after the pneumonia diagnosis. There was no significant difference between the survivor and non-survivor groups in terms of PCT on the day of pneumonia diagnosis or CRP levels at any point. However, the PCT levels days 3 and 7 were significantly higher in the non-survivor group than the survivor group. Whereas PCT levels decreased significantly from D0 to D7 in the survivor group, CRP did not. A PCT level above 1 ng/mL on day 3 was the strongest predictor of mortality, with an odds ratio of 22.6. CONCLUSION: Serum PCT was found to be a superior prognostic marker compared to CRP in terms of predicting mortality in critically ill patients who developed VAP. The PCT level on D3 was the strongest predictor of mortality in VAP.

  13. Correlation between abdominal infections and change of serum procalcitonin level%腹腔感染与血清降钙素原水平变化的相关性分析

    吴新军; 王雷; 秦玉刚; 王煜霞; 金建云; 闫争强

    2013-01-01

    目的 分析腹腔感染与血清降钙素原(PCT)水平变化的关系,为腹腔感染的治疗及预后判断提供参考.方法 选取医院收治的66例腹腔感染患者为观察组,根据感染程度不同分为一般感染组40例,重症感染组26例,另选取32名健康志愿者为对照组,应用双抗夹心免疫发光法测定观察组和对照组患者PCT水平.结果 重症感染组患者PCT水平为(67.47±12.83)μg/L,一般感染组为(17.19±5.45)μg/L,对照组为(0.33±0.07)μg/L,3组数据比较差异有统计学意义(P<0.05),进一步经Newmen-Keuls法检验,重症感染组高于一般感染组和对照组(P<0.05),一般感染组高于对照组(P<0.05);APACHE-Ⅱ评分重症感染组为(23.18±5.28)分,一般感染组为(3.23±1.87)分,比较差异有统计学意义(P<0.05);观察组不同程度感染组患者PCT水平与APACHE-Ⅱ评分呈正相关(P<0.05);观察组治疗前PCT水平为(40.19±8.78) μg/L、治疗后PCT水平为(6.29±2.10)μg/L,对照组PCT水平为(0.33±0.07)μg/L,3组数据比较差异有统计学意义(P<0.05),进一步经Newmen-Keuls法检验,观察组治疗前高于治疗后和对照组(P<0.05),治疗后与对照组比较差异无统计学意义.结论 血清降钙素原可反映腹腔感染的严重程度,并对治疗效果和预后的判断有重要意义.%OBJECTIVE To analyze the correlation between the abdominal infections and the change of level of serum procalcitonin so as to provide basis for the treatment of abdominal infections and the judgment of prognosis.METHODS A total of 66 cases of patients with abdominal infections were selected as the research objects and were divided into the general infection group with 40 cases and the severe infection group with 26 cases according to the severity of the infections,and 32 cases of healthy volunteers were selected as the control group,the levels of the serum procalcitonin of the two groups were determined by using double anti-sandwich immune

  14. Hubungan Kadar Procalcitonin dengan beratnya Pneumonia Komunitas

    Manullang, Doharjo

    2016-01-01

    Background The assessment of level severity in patient with Community Acquired Pneumonia (CAP) is very important determine the next management of disease. Procalcitonin (PCT) is known as one of biomarker sepsis and infection. The application of PCT is known to be used in diagnosis, to help clinician to decide antibiotic treatment and to make prognosis. It is still controversy whether the PCT early admission is related in clinical scoring system or prognostic score. Objective To...

  15. Impact of Low Procalcitonin Results on Antibiotic Administration in Hospitalized Patients at a Tertiary Care Center.

    Brennan, Meghan B; Osterby, Kurt; Schulz, Lucas; Lepak, Alexander J

    2016-06-01

    Procalcitonin is a sensitive and specific marker of bacterial infection; low results allow clinicians to safely de-escalate antibiotics. This retrospective cohort study aimed to determine the effect of low procalcitonin results on withholding, discontinuing, or de-escalating antibiotics in hospitalized patients at a tertiary care center. Antibiotics were initiated or continued without de-escalation in 55% of patients with low procalcitonin results. Among patients with low procalcitonin results, the primary service, but not measures of patient complexity, disease severity, or underlying disease process (lower respiratory tract infection evaluation versus systemic inflammatory response syndrome/possible sepsis) was associated with initiation or continued broad-spectrum antibiotic use. Provider-level factors may be an important variable in the initiation or continued use of broad-spectrum antibiotics for patients with low procalcitonin levels. PMID:27251126

  16. 老年脓毒症患者血浆D-二聚体和降钙素原水平变化∗%The Changes of Plasma Levels of D-dimer and Procalcitonin in Elderly Patients with Sepsis

    杨勇文; 李从荣#

    2015-01-01

    目的::回顾性分析 D-二聚体和降钙素原水平在老年脓毒症患者中的变化。方法:将172例老年脓毒症患者按预后分为生存组(n=115)和死亡组(n=57);采用免疫比浊法和电化学发光法分别检测两组患者入院时血浆 D-二聚体和降钙素原水平,比较血浆 D-二聚体、降钙素原水平和急性生理与慢性健康状况评分(APACHEⅡ评分)的组间差异及其相关性。结果:生存组血浆 D-二聚体和降钙素原水平和 APACHEⅡ评分均低于死亡组(P<0.01);老年脓毒症患者血浆 D-二聚体和降钙素原水平与 APACHEⅡ评分存在明显正相关性(r 分别为0.352、0.234,P <0.05)。结论:不同预后的老年脓毒症患者血浆 D-二聚体和降钙素原水平存在差异,监测这两个生物学指标对老年脓毒症患者的预后具有一定的参考价值。%Objective:To analysis the changes of D-dimer,procalcitonin levels in elderly patients with sepsis. Method:1 72 cases of elderly patients with sepsis were divided into survival group (n=1 1 5)and death group (n=57).When patients admitted to hospital,immune turbidimetric method and electrochemical luminescence method were used respectively to detect the plasma D-dimer and procalcitonin levels.The plasma D-dimer,procalcitonin lev-els and acute physiology and chronic health evaluation (APACHE Ⅱ score)differences between groups and their correlation were analyzed.Results:Survival group of plasma D-dimer and procalcitonin levels and APACHE Ⅱscores were lower than the death group with statistical significance (P <0.01 ).Plasma D-dimer and procalcitonin levels and APACHE Ⅱ scores were significantly positive correlations (r = 0.352,0.234,P < 0.05 ).Conclusion:There were differences in plasma of D-dimer and procalcitonin levels of in the elderly sepsis patients with different prognosis.The two biological indicators had certain reference value for the prognosis of elderly patients with sepsis.

  17. Serum procalcitonin level and SOFA score at discharge from the intensive care unit predict post-intensive care unit mortality: a prospective study.

    Yosuke Matsumura

    Full Text Available PURPOSE: The final decision for discharge from the intensive care unit (ICU is uncertain because it is made according to various patient parameters; however, it should be made on an objective evaluation. Previous reports have been inconsistent and unreliable in predicting post-ICU mortality. To identify predictive factors associated with post-ICU mortality, we analyzed physiological and laboratory data at ICU discharge. METHODS: Patients admitted to our ICU between September 2012 and August 2013 and staying for critical care>2 days were included. Sequential Organ Failure Assessment (SOFA score; systemic inflammatory response syndrome score; white blood cell count; and serum C reactive protein, procalcitonin (PCT, interleukin-6 (IL-6, lactate, albumin, and hemoglobin levels were recorded. The primary end point was 90-day mortality after ICU discharge. Two hundred eighteen patients were enrolled (195 survivors, 23 non-survivors. RESULTS: Non-survivors presented a higher SOFA score and serum PCT, and IL-6 levels, as well as lower serum albumin and hemoglobin levels. Serum PCT, albumin, and SOFA score were associated with 90-day mortality in multiple logistic regression analysis. Hosmer-Lemeshow test showed chi-square value of 6.96, and P value of 0.54. The area under the curve (95% confidence interval was 0.830 (0.771-0.890 for PCT, 0.688 (0.566-0.810 for albumin, 0.861 (0.796-0.927 for SOFA score, and increased to 0.913 (0.858-0.969 when these were combined. Serum PCT level at 0.57 ng/mL, serum albumin at 2.5 g/dL and SOFA score at 5.5 predict 90-day mortality, and high PCT, low albumin and high SOFA groups had significantly higher mortality. Serum PCT and SOFA score were significantly associated with survival days after ICU discharge in Cox regression analysis. CONCLUSIONS: Serum PCT level and SOFA score at ICU discharge predict post-ICU mortality and survival days after ICU discharge. The combination of these two and albumin level might enable

  18. CHANGES OF SEURM PROCALCITONIN LEVELS IN MIGRAINE PATIENTS%偏头痛患者血清降钙素原水平的变化

    陈东平; 侯淑红; 张志坚; 陈衍贵; 陈明生

    2011-01-01

    Objective: To investigate the changes of serum procalcitonin (PCT) levels in patients with migraine and the underlying mechanism of migraine. Method: 163 adult patients with migraine were divided into two main groups: migraine during headache attack period (n = 80) and migraine during headache free period (n = 83). These patients were further divided into four subgroups according to with or without aura. The serum levels of PCT in all patients were measured. Result: PCT levels in patients with migraine during headache attack period were significantly higher than those during headache free period (P < 0.01). PCT levels in patients with migraine with aura and in patients with migraine without aura during headache attack period were also significantly higher than those during headache free period (P < 0.01). Conclusion: PCT may be an inflammatory marker for migraine attacks, and was response for one of the underlying mechanisms of migraine attacks.%目的:观察偏头痛患者血清降钙素原(PCT)水平的变化,探讨偏头痛可能的发病机制.方法:将163例偏头痛患者分成偏头痛发作期组(n=80)和偏头痛发作间期组(n=83).根据患者有无先兆症状进一步分成四个亚组:无先兆偏头痛的发作期组(n=68)、先兆偏头痛的发作期组(n=12)、无先兆偏头痛的发作间期组(n=70)、先兆偏头痛的发作间期组(n=13).测定每组患者血清PCT水平.结果:所有偏头痛患者中,偏头痛发作期PCT水平明显高于发作间期(P<0.01).在无先兆偏头痛或先兆偏头痛患者中,偏头痛发作期PCT水平也分别明显高于发作间期(P<0.01).结论:PCT可能是偏头痛发作的一个炎症标志,是偏头痛发作的潜在机制之一.

  19. 血清降钙素原检测在新生儿细菌性肺炎中的临床意义%The Clinical Signiifcance of Serum Level of Procalcitonin in Diagnosis of Neonatal Bacterial Pneumonia

    谭长英; 崔亚利

    2016-01-01

    目的探究血清降钙素原(Procalcitonin,PCT)检测在新生儿细菌性肺炎早期诊断中的临床应用。方法回顾性分析2015年5~7月,华西第二医院新生儿科确诊的新生儿肺炎细菌感染组49例,非细菌感染38例,检测血清降钙素原,观察阳性率及其在新生儿细菌性肺炎早期诊断中的应用价值。结果新生儿肺炎细菌感染组及非细菌感染组降钙素原阳性率差异具有统计学意义(P<0.05),在新生儿细菌性肺炎早期诊断中具有临床应用价值。结论降钙素原检测能鉴别细菌性炎症与非细菌性炎症反应,在新生儿细菌性肺炎早期诊断中具有指导意义,能够判断细菌感染的严重程度及预后,以便指导临床抗生的合理应用。%Objective To explore the clinical signiifcance of serum level of procalcitonin in the diagnosis of neonatal bacterial pneumonia. Methods Select 49 cases as newborn pneumonia bacterial infection group, and 38 cases as non-bacterial infection group, which used as control group, all the serum procalcitonin data were got from department of laboratory medicine, west china second university hospital, sichuan university, from May to July in 2015. Results Neonatal pneumonia bacteria infection and the non-bacterial infection group procalcitonin original positive rate were signiifcant (P<0.05). Conclusion Procalcitonin can be used to identify bacterial inlfammation and non-bacterial inlfammatory reaction, and to determine the severity and prognosis of bacterial infection in order to guide the rational use of antibiotics.

  20. Elevated procalcitonin is associated with increased mortality in patients with scrub typhus infection needing intensive care admission

    John Victor Peter

    2013-01-01

    Full Text Available Context: Procalcitonin is a biomarker of bacterial sepsis. It is unclear if scrub typhus, a rickettsial illness, is associated with elevated procalcitonin levels. Aim: To assess if scrub typhus infection is associated with high procalcitonin levels and whether high levels portend a poorer prognosis. Setting and Design: Retrospective study of patients with severe scrub typhus infection, admitted to the medical intensive care unit of a tertiary care university affiliated teaching hospital. Materials and Methods: Eighty-four patients with severe scrub typhus infection that also had procalcitonin levels were assessed. Statistical Analysis: Relationship between procalcitonin and mortality explored using univariate and multivariate analyses. Results: The mean (±standard deviation age was 40.0 ± 15.5 years. Patients were symptomatic for 8.3 ± 4.3 days prior to presentation. The median admission procalcitonin level was 4.0 (interquartile range 1.8 to 8.5 ng/ml; 59 (70.2% patients had levels >2 ng/ml. Invasive mechanical ventilation was required in 65 patients; 20 patients died. On univariate analysis, admission procalcitonin was associated with increased odds of death [odds ratio (OR 1.09, 95% confidence interval (CI 1.03 to 1.18]. On multivariate logistic regression analysis including procalcitonin and APACHE-II score, the APACHE-II score was significantly associated with mortality (OR 1.16, 95% CI 1.06 to 1.30, P = 0.004 while a trend was observed with procalcitonin (OR 1.05, 95%CI 1.01 to 1.13, P = 0.09. The area under the receiver operating characteristic (ROC curve, AUC, for mortality was 0.77 for procalcitonin and 0.78 for APACHE-II. Conclusions: Procalcitonin is elevated in severe scrub typhus infection and may be associated with higher mortality.

  1. Sensitivity and specificity of serum procalcitonin level compared to leucocyte count for diagnosis of surgical site infection on patients undergoing major surgery

    Muhammad Sayuti; Supomo; Umi Sholekah Intansari

    2016-01-01

    Surgical site infection (SSI) is one of the most serious complications on sugical procedure. However, its diagnosis is still based on the clinical and laboratory examination that take more time and less sensitive and specific. Therefore, early diagnosis that is more accurate and precise is needed. Some biomarker such as serum procalcitonin (PCT) is promoted for diagnosis SSI. The aim of the study was to evaluate the sensitivity and specificity of serum PCT compared with leucocy...

  2. Difference in procalcitonin level of patients with fungal infections and its relationship with prognosis%不同真菌感染对降钙素原的差异与疾病预后的关系

    魏万昆; 万程彬; 张毅

    2015-01-01

    目的:观察不同真菌感染降钙素原的差异性,并对其与疾病预后的相关性进行分析。方法选取2012年6月-2013年6月于IC U就诊的危重病患者54例,根据危险评分分组,非危重组24例、危重组25例、极危重组5例;研究不同感染部位血清降钙素原水平、不同菌株感染血清降钙素原水平以及降钙素原与疾病预后的相关性。结果54例真菌感染患者中肺部感染26例占48.15%、消化道感染12例占22.21%、泌尿道感染9例占16.67%、血流感染9例占12.96%;不同感染部位血清降钙素原水平具有一定差异性,其中血清降钙素原水平较其他部位明显偏高,差异有统计学意义( P<0.05);共培养出病原菌86株,其中白色假丝酵母菌占55.81%,热带假丝酵母菌占37.21%,克柔假丝酵母菌占6.98%,降钙素原水平差异无统计学意义;随着危重程度的不断升高,降钙素原水平逐渐增高,组间差异有统计学意义(P<0.05),PCT与危重评分呈正相关(P<0.05)。结论降钙素原对真菌感染的诊断有重大意义,但不同菌株间差异无显著性,其水平与疾病危重程度密切相关。%OBJECTIVE To observe the difference in the procalcitonin level of the patients with different fungal in‐fections and explore its relationship with the prognosis of disease .METHODS A total of 54 critically ill patients who were treated in the ICU from Jun 2012 to Jun 2013 were enrolled in the study and divided into the non‐critical‐ly ill group with 24 cases ,the critically ill group with 25 cases ,and the extremely critically ill group with 5 cases according to the score of risk .The levels of procalcitonin of the patients with different sites of infections ,the levels of procalcitonin of the patients with infections due to different species of pathogens ,and the relationship between the level of procalcitonin and the prognosis of

  3. Comparative Study of Plasma Endotoxin with Procalcitonin Levels in Diagnosis of Bacteremia in Intensive Care Unit Patients

    Tao Wang

    2016-01-01

    Conclusions: Plasma endotoxin was more related to GN than to Gram-positive bacteremia, and that endotoxin level was species dependent, but PCT level remained relatively more stable within the GN bacteria caused bacteremia. Both GN and positive bacteria caused bacteremia in the ICU patients in different regions of China. And PCT is a more valuable biomarker than endotoxin in the diagnosis of bacteremia.

  4. Role of serum procalcitonin level in early diagnosis of bacterial pneumonia in children, a hospital based study

    Sheikh Mohd Saleem

    2016-05-01

    Conclusions: Serum PCT is an important biomarker for prompt diagnosis of bacterial infection and a sensitive indicator to distinguish bacterial from non-bacterial pneumonia. Evaluating serum PCT levels helps in early use of antibiotic therapy and prognosis of underlying disease. [Int J Res Med Sci 2016; 4(5.000: 1518-1521

  5. Diagnostic value of soluble CD163 serum levels in patients suspected of meningitis: comparison with CRP and procalcitonin

    Knudsen, Troels Bygum; Larsen, Klaus; Kristiansen, Thomas Birk;

    2007-01-01

    The aim of the study was to evaluate and compare the diagnostic value of sCD163 serum levels with CRP and PCT in meningitis and bacterial infection. An observational cohort study was conducted between February 2001 and February 2005. The study population comprised 55 patients suspected of meningi...

  6. Procalcitonin as a Marker of Neonatal Sepsis

    Mohmoud Hajiahmadi

    2009-04-01

    Full Text Available Objective:Early diagnosis of neonatal sepsis and appropriate treatment decreases the mortality and morbidity of these infants. The aim of this study was to assess the role of procalcitonin (PCT as a marker in the early diagnosis, treatment and follow-up of neonatal sepsis. Methods:Thirty-eight neonates with clinical (n=8, suspected (n=19 and proven sepsis (n=11 were evaluated. The PCT levels were measured by immunoluminoassay before and on day 5 of treatment. PTC levels of 0.5-2 ng/ml, 2.1-10 ng/ml and >10 ng/ml were considered as weakly positive, positive, and strongly positive, respectively. The sepsis screen tests and cultures of blood or other sterile body fluids in these three groups of infants were recorded. Findings:The levels of PCT in proven sepsis group were higher than that in other groups. Strongly positive PTC level was seen in none of 8 cases of clinical sepsis, 4 of 19 suspected and in 10 of 11 cases with proven sepsis. PCT levels were dramatically decreased in three groups on day 5 of treatment. Conclusion:The results show that the serum procalcitonin levels seem to be significantly increased in proven sepsis and decrease dramatically in all types of sepsis after appropriate treatment.

  7. Maternal Plasma Procalcitonin Concentrations in Pregnancy Complicated by Preterm Premature Rupture of Membranes

    Andrzej Torbé

    2007-01-01

    Full Text Available Objectives. Our objective is to compare maternal plasma procalcitonin concentrations in preterm premature rupture of membranes (pPROM and premature rupture of membranes (PROM at term with their levels in uncomplicated pregnancy, and to determine whether these concentrations are useful in the diagnosis of pPROM cases suspected of infection and in the prediction of pPROM-to-delivery interval. Study design. Forty eight patients with pPROM, 30 with PROM at term, 31 healthy women at preterm gestation, and 33 healthy women at term were included. In pPROM group, analysis of procalcitonin concentrations with reference to leucocytosis, serum C-reactive protein, vaginal fluid culture, neonatal infection, histological chorioamnionitis and pPROM-to-delivery interval was carried out. Results. Procalcitonin concentrations in pPROM and PROM at term cases were comparable. However, in both groups procalcitonin values were significantly higher than in healthy controls in approximate gestational age. In pPROM group, procalcitonin concentrations between the patients with and without laboratory indices of infection were comparable, as well as between patients who gave birth to newborns with and without congenital infection, and between patients with and without histological chorioamnionitis. The predictive values of procalcitonin determinations were poor. Conclusion. The value of maternal plasma procalcitonin determinations in the diagnostics of pPROM cases suspected of intraamniotic infection, as well as for the prediction of pPROM-to-delivery interval, newborn's infection or histological chorioamnionitis is unsatisfactory. However, procalcitonin concentrations are elevated, both in patients with preterm and term PROMs in comparison to healthy pregnants, and therefore further evaluations are necessary to establish the role of procalcitonin in the pathophysiology of pregnancy.

  8. Diagnostic value of soluble CD163 serum levels in patients suspected of meningitis: comparison with CRP and procalcitonin

    Knudsen, Troels Bygum; Larsen, Klaus; Kristiansen, Thomas Birk; Møller, Holger Jon; Tvede, Michael; Eugen-Olsen, Jesper; Kronborg, Gitte

    The aim of the study was to evaluate and compare the diagnostic value of sCD163 serum levels with CRP and PCT in meningitis and bacterial infection. An observational cohort study was conducted between February 2001 and February 2005. The study population comprised 55 patients suspected of...... marker for distinguishing bacterial infection from non-bacterial disease (specificity 0.91; sensitivity 0.47). However, the overall diagnostic accuracy of CRP (AUC =0.91) and PCT (AUC =0.87) were superior (p<0.02 and p<0.06) compared to that of sCD163 (AUC =0.72). For the diagnosis of systemic bacterial...... infection, the AUC of sCD163 (0.83) did not differ significantly from those of CRP or PCT. All markers had AUCs <0.75 for differentiating between purulent meningitis and other conditions. In conclusion, CRP and PCT had high diagnostic value and were superior as markers of bacterial infection compared to s...

  9. Procalcitonin for detecting community-acquired bacterial pneumonia

    Devi Gusmaiyanto

    2016-06-01

    Full Text Available Background Pneumonia is a major cause of morbidity andmortality in children under five years of age. Pneumonia can be ofbacterial or viral origin. It is difficult to distinguish between thesetwo agents based on clinical manifestations, as well as radiologicaland laboratory examinations. Furthermore, bacterial cultures taketime to incubate and positive results may only be found in 10-30%of bacterial pneumonia cases. Procalcitonin has been used as amarker to distinguish etiologies, as bacterial infections tend toincrease serum procalcitonin levels.Objective To determine the sensitivity, specificity, positivepredictive value and negative predictive value of procalcitoninin community-acquired bacterial pneumonia.Method This cross-sectional study was conducted in thePediatric Health Department of Dr. M. Djamil Hospital, Padang.Subjects were selected by consecutive sampling. Procalcitoninmeasurements and PCR screening were performed on bloodspecimens from 32 pneumonia patients and compared.Results Of the 32 subjects, most were boys (56.25%, under 5years of age (99%, and had poor nutritional status (68.75%.Using a cut-off point of 0.25 ng/mL, procalcitonin level hada sensitivity of 92%, specificity 50%, positive predictive value 88%, and negative predictive value 60% for diagnosing bacterial pneumonia. Using a cut-off point of 0.5 ng/mL, procalcitonin level had a specificity of 46%, specificity 83%, positive predictive value 91%, and negative predictive value 25%.Conclusion A cut-off point of 0.25 ng/mL of procalcitonin level may be more useful to screen for bacterial pneumonia than a cutoff point of 0.5 ng / mL. However, if the 0.25 ng/mL cut-off point is used, careful monitoring will be required for negative results, as up to 40% may actually have bacterial pneumonia. [PaediatrIndones. 2015;55:65-9.].

  10. Hubungan Procalcitonin dengan Skor Pneumonia Severity Indeks (PSI) Untuk Menilai Tingkat Keparahan Penyakit Pneumonia Komuniti di RSUP H. Adam Malik Medan

    Siregar, Ahmad Aswar

    2016-01-01

    Background: procalcitonin as a biomarker for acute bacterial infection which is commonly used recently. Objective: This study is trying to find the relationship between Procalcitonin and PSI scores to asses the severity of CAP. Methods: This study used longitudinal data collection approach without a control group. Patients with a diagnosis of Community Acquired Pneumonia were checked the Procalcitonin levels and measured the PSI scores on the first and third day of hospitalization. ...

  11. Ability of procalcitonin to discriminate infection from non-infective inflammation using two pleural disease settings.

    Fiona J McCann

    Full Text Available Procalcitonin has been shown to be useful in separating infection from non-infective disorders. However, infection is often paralleled by tissue inflammation. Most studies supporting the use of procalcitonin were confounded by more significant inflammation in the infection group. Few studies have examined the usefulness of procalcitonin when adjusted for inflammation.Pleural inflammation underlies the development of most exudative effusions including pleural infection and malignancy. Pleurodesis, often used to treat effusions, involves provocation of intense aseptic pleural inflammation. We conducted a two-part proof-of-concept study to test the specificity of procalcitonin in differentiating infection using cohorts of patients with pleural effusions of infective and non-infective etiologies, as well as subjects undergoing pleurodesis.We measured the blood procalcitonin level (i in 248 patients with pleural infection or with non-infective pleural inflammation, matched for severity of systemic inflammation by C-reactive protein (CRP, age and gender; and (ii in patients before and 24-48 hours after induction of non-infective pleural inflammation (from talc pleurodesis.1 Procalcitonin was significantly higher in patients with pleural infection compared with controls with non-infective effusions (n = 32 each group that were case-matched for systemic inflammation as measured by CRP [median (25-75%IQR: 0.58 (0.35-1.50 vs 0.34 (0.31-0.42 µg/L respectively, p = 0.003]. 2 Talc pleurodesis provoked intense systemic inflammation, and raised serum CRP by 360% over baseline. However procalcitonin remained relatively unaffected (21% rise. 3 Procalcitonin and CRP levels did not correlate. In 214 patients with pleural infection, procalcitonin levels did not predict the survival or need for surgical intervention.Using a pleural model, this proof-of-principle study confirmed that procalcitonin is a biomarker specific for infection and is not affected by non

  12. Comparison between Procalcitonin, Brain Natriuretic Peptide, and Uric Acid in Children with Cardiomyopathy and Controls

    Noor Mohammad Noori

    2015-01-01

    Full Text Available Objective. This study was performed to determine the level of procalcitonin, Brain Natriuretic Peptide (BNP, and uric acid in children with cardiomyopathy in comparison with controls and the association with echocardiographic findings. Methods. The levels of BNP, procalcitonin, and serum uric acid were measured and the amounts of biomarkers compared with echocardiographic findings. Results. In this study mean age of participants was the same (p=0.321. The majority of echocardiographic indices in left and right heart have different means in case and controls (p<0.05. Means of BNP, procalcitonin, and uric acid were 213.814 ± 309.601, 9.326 ± 3.881, and 6.846 ± 1.814 for case group and 2.76 ± 1.013, 1.851 ± 1.466, and 3.317 ± 0.924 for control (p<0.001, respectively. In the patients group there was relationship of Ross classification with BNP (χ2 = 15.845, p<0.05 and with age (χ2 = 8.946, p<0.05. For uric acid and procalcitonin no significant relationships were observed. Conclusions. procalcitonin, uric acid, and BNP had significant relationship with many echocardiographic findings in participants. For patients, procalcitonin did not show correlation. The severity of illness based on the Ross classification showed significant correlation with BNP level and age in patients.

  13. Study on the changes of serum procalcitonin and interleukin - 6 levels among the neonates with sepsis%新生儿败血症患儿血清降钙素原及白介素-6水平变化研究

    陆彩霞; 王海兰; 李春娥

    2012-01-01

    Objective; To explore the values of serum procalcitonin and interleukin -6 levels in early diagnosis of neonatal sepsis. Methods; Forty neonates with sepsis and forty healthy neonates were selected as research objects, the serum procalcitonin and interleukin - 6 levels during acute phase and recovery phase in sepsis group and control group were detected. Results: Hie serum procalcitonin and interleukin - 6 levels during acute phase in sepsis group were significantly higher than those in control group ( P 0. 05 ) . The serum procalcitonin and interleukin -6 levels during acute phase in sepsis group were significantly higher than those during recovery phase in sepsis group (P <0.05) . Conclusion: There is a positive correlation between serum procalcitonin and interleukin -6 levels and the degree of severity of neonatal sepsis, serum procalcitonin and interleukin -6 levels can be used as important indexes for early diagnosis and evaluation of prognosis in the neonates with sepsis.%目的:探讨血清降钙素原及白介素-6水平在新生儿败血症早期诊断中的价值.方法:选择40例败血症新生儿及40例健康新生儿作为研究对象,测定败血症组急性期、恢复期及健康对照组血清降钙素原及白介素-6水平.结果:败血症组急性期血清降钙素原及白介素-6水平显著高于对照组(P<0.05).败血症组恢复期和对照组血清降钙素原及白介素-6水平比较,差别无统计学意义(P>0.05).败血症组急性期血清降钙素原及白介素-6水平显著高于恢复期(P<0.05).结论:血清降钙素原及白介索-6水平和新生儿败血症严重程度呈正相关性,血清降钙素原及白介素-6水平可作为新生儿败血症早期诊断及评价预后的重要指标.

  14. Procalcitonin Strip Test as an Independent Predictor in Acute Pancreatitis.

    Dias, Brendan Hermenigildo; Rozario, Anthony Prakash; Olakkengil, Santosh Antony; V, Anirudh

    2015-12-01

    Plasma procalcitonin (PCT) is a highly specific marker for the diagnosis of bacterial infection and sepsis. Studies have demonstrated its role in the setting of sepsis and acute pancreatitis. This study aims to analyze and compare the prognostic efficacy of plasma procalcitonin strip test in acute pancreatitis. A prospective study was conducted in the department of general surgery from June 2012 to June 2013. Plasma procalcitonin was estimated by the semiquantitative strip test. The study included a total of 50 patients diagnosed to have acute pancreatitis. Data was collected and statistically analyzed using SPSS version 17. Thirty-nine out of the 50 patients (78 %) were males with a mean age of 46.8 years (range, 25-78 years) and 25 patients (50 %) had ethanol-induced pancreatitis, while 13 patients (26 %) had gall stone pancreatitis. Plasma PCT values were found to correlate better than CRP levels and total leukocyte count with the total duration of hospitalization, ITU, and ICU stay, as well as with the progression to severe acute pancreatitis. A cut off for plasma PCT of >2 ng/mL was found to be 100 % sensitive and 100 % specific and a cut off for CRP of >19 mg/dL was 70 % sensitive and 65 % specific for predicting the progression to severe acute pancreatitis. Plasma PCT also correlated well with antibiotic requirement. A cut off value of >0.5 ng/mL for plasma PCT was 100 % sensitive and 80 % specific and a cut off value of >18 mg/dL for CRP was 86 % sensitive and 63 % specific for predicting antibiotic requirement. Plasma procalcitonin is an early and reliable prognostic indicator in acute pancreatitis. The procalcitonin strip test is a rapid test which is useful in analyzing prognosis in patients with acute pancreatitis. PMID:27011501

  15. The Value of C-Reactive Protein and Procalcitonin in Febrile Neutropenia

    Solmaz Çelebi

    2009-06-01

    Full Text Available Aim: Febrile neutropenia is the major cause of mortality and morbidity in cancer patients. For this reason, early diagnosis of severe infections and appropriate antimicrobial therapy are very important. The aim of this study was to investigate the difference between C-reactive protein (CRP and procalcitonin in determining the sepsis and its severity. Materials and Method: A total of 30 children (35 episodes with febrile neutropenia who were hospitalized in the Uludag University, Pediatric Hematology and Oncology Unit were included in this prospective study. The blood samples for CRP and procalcitonin were collected daily between 0 to 5th days. Serum CRP and procalcitonin levels were compared with culture positivity, prolonged fever, mucositis and absolute granulosit count (AGC. Results: A total of 16 patients (56% diagnosed with acute leukemia and, 14 patients (46% having solid tumours were evaluated. In sequential analysis of febrile episodes, both the median of procalcitonin and the CRP concentrations showed the same tendency and there was no significant correlation between them (r=0.2, p>0.05. There was no significant association between CRP and procalcitonin among those having positive culture and mucositis. However, CRP values at the 3rd, 4th and 5th days were significantly higher in the patients with AGC100/mm3. Similarly, CRP values were significantly higher at the 1st, 2nd, 3rd and 4th days among the patients having prolonged fever. Conclusion: Our study suggests that there is no difference between CRP and procalcitonin in determining sepsis and its severity. Although procalcitonin is a valuable acute phase reactant in non-neutropenic patients, larger prospective investigations are needed to show the prognostic value of procalcitonin in neutropenic patients. (Journal of Current Pediatrics 2009; 7: 7-12

  16. Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections

    Alireza Monsef

    2012-09-01

    Full Text Available Objective: This study tried to assess sensitivity, specificity, positive and negative predictive value of procalcitonin for diagnosis of neonatal bacterial infections.Methods: This prospective cross sectional study was carried out during an 18-month period in NICU and neonatal wards of Besat Hospital in Hamedan province, Iran. 39 symptomatic infants with clinical and laboratory findings in favor of bacterial infection with a positive blood, CSF, and/or supra pubic urine cultureentered the study; 32 newborns without any bacterial infection served as control group. Quantitative procalcitonin level ≥0.5 ng/ml was accepted as pathological. Finally sensitivity, specificity, positive (PPV and negative predictive value (NPV were calculated for procalcitonin test.Findings: 20 blood cultures, 17 urine cultures and 8 CSF cultures were positive. Sensitivity, specificity, PPV and NPV for procalcitonin test was 76.9%, 100%, 100% and 78% respectively. Diagnostic value of procalcitonin test in accordance with blood culture for mentioned items was 85%, 100%, 100% and 91.4%respectively. Its diagnostic value according to urine culture was: sensitivity 70.6%, specificity 100%, PPV 100% and NPV 86.4%, and according to CSF culture was: sensitivity 75%, specificity 100%, PPV 100% and NPV 94.1% respectively.Conclusion: The results show that the procalcitonin test has high sensitivity, specificity, PPV and NPV for diagnosis of neonatal infections.

  17. PROCALCITONIN TEST IN RHEUMATIC DISEASES

    G. M. Tarasova

    2014-01-01

    Full Text Available Estimation of serum procalcitonin (PCT levels is of great interest in rheumatology in both the diagnosis of coinfectionsand the differential diagnosis between rheumatic disease activity and the current infectious process.Objective: to estimate the value of PCT as a specific marker for generalized and local infection in rheumatic patients.Subjects and methods. A retrospective study investigated the case histories of 100 inpatients examined and treated at the V.A. Nasonova Research Institute of Rheumatology. Serum PCT concentrations were determined by a quantitative electrochemiluminescence assay using a Cobas E 411 analyzer (Roche, Switzerland.Results. Infectious diseases were diagnosed in 41 of the 100 patients. The infectious process was generalized and local in 11 and 30 cases, respectively. In the patients with generalized infection, the level of PCT was more than 2.0 ng/ml in 81.8% of the cases. In the local infection and non-infection groups, it was below 0.5 mg/ml in 70 and 84.7% ofcases, respectively. In the generalized infection group, the content of PCT was significantly higher (3.6 [2.3; 10.5] than in the local infection (0.24 [0.15; 0.7]; р = 0.004 and non-infection (0.15 [0.09; 0.26]; р = 0.0001 groups. It did not depend on rheumatic disease activity. C-reactive protein (CRP levels and erythrocyte sedimentation rate (ESRcorrelated with PCT concentrations in different patient groups. ROC analysis showed the optimal sensitivity (82% and specificity (98% of PCT as a marker of systemic infection only in the rheumatic patients with its concentration of ≥2.3 ng/ml.Conclusion. The determination of PCT is certain to contribute to the diagnosis of generalized infections and the differential diagnosis of systemic rheumatic diseases and infectious ones.

  18. Serum procalcitonin is a marker for prediction of readmission from an intermediate care to an acute care hospital in neurosurgical patients

    Jia Xu Lim

    2015-01-01

    Conclusion: Procalcitonin is a pro-hormone known to correlate with infection and poor neurological status. We have found that its serum values correlate significantly with the readmission rates of neurosurgical patients in our study. We postulate that by ensuring normality in procalcitonin levels prior to transfer to an intermediate care facility, potentially half of neurosurgical readmissions can be prevented.

  19. Diagnostic Accuracy of Procalcitonin in Bacterial Meningitis Versus Nonbacterial Meningitis

    Wei, Ting-Ting; Hu, Zhi-De; Qin, Bao-Dong; Ma, Ning; Tang, Qing-Qin; Wang, Li-li; ZHOU, Lin; Zhong, Ren-Qian

    2016-01-01

    Abstract Several studies have investigated the diagnostic accuracy of procalcitonin (PCT) levels in blood or cerebrospinal fluid (CSF) in bacterial meningitis (BM), but the results were heterogeneous. The aim of the present study was to ascertain the diagnostic accuracy of PCT as a marker for BM detection. A systematic search of the EMBASE, Scopus, Web of Science, and PubMed databases was performed to identify studies published before December 7, 2015 investigating the diagnostic accuracy of ...

  20. Evapotranspiration Partitioning and Response to Abnormally Low Water Levels in a Floodplain Wetland in China

    Xiaosong Zhao; Yuanbo Liu

    2016-01-01

    Evapotranspiration (ET) is an important component of the wetland water budget. Water level declines in Poyang Lake, the largest freshwater lake in China, have caused concerns, especially during low water levels. However, how wetland ET and its partitioning respond to abnormally low water levels is unclear. In this study, wetland ET was estimated with MODIS data and meteorological data. The wetland ET partitioning and its relationship with abnormally low water levels were analyzed for 2000–201...

  1. Procalcitonin kinetics as a prognostic marker in severe sepsis/septic shock

    Banani Poddar

    2015-01-01

    Full Text Available Background and Aims: To evaluate the prognostic value of change (fall in serum procalcitonin level (PCT in critically ill adults with severe sepsis/septic shock. Methods: This was a prospective observational study in a general purpose Intensive Care Unit of a teaching Institute. PCT was measured at admission (D0 and after 72-96 h (D4 by electrochemi-luminescence immunoassay (BRAHMS PCT kit in adults (>18 years admitted with severe sepsis or septic shock. Change in procalcitonin values from D0 to D4 was correlated with the primary outcome, that is, 28 days mortality. All results are reported as median (interquartile range. Results: A total of 171 (100 males of 181 patients were included. The median age was 46 years (range 19-79. 137 patients were in septic shock and 34 in severe sepsis. The sequential organ failure assessment (SOFA score in all patients was 11 (9-14.91 (53.2% patients survived at 28 days (survivors. The baseline procalcitonin was similar in two groups (3.48 [1.04-15.85] vs. 5.27 [1.81-23.57] ng/ml in survivors and nonsurvivors [NS] respectively. The procalcitonin change was 1.58 (0.20-8.52 in survivors and 0.28 (-1.38-6.17 in NS (P = 0.01. The C-statistic of percentage change in procalcitonin from D0 to D4 to predict survival was 0.73 (95% confidence interval [CI]: 0.65-0.82 when compared to 0.78 (95% CI: 0.71-0.86 for change of SOFA score. For an absolute fall in procalcitonin of >1 ng/ml, a 70% fall predicted survival with 75% sensitivity and 64% specificity. Conclusions: In critically ill-patients with severe sepsis/septic shock, change (fall in procalcitonin is associated with good outcome.

  2. Value of soluble TREM-1, procalcitonin, and C-reactive protein serum levels as biomarkers for detecting bacteremia among sepsis patients with new fever in intensive care units: a prospective cohort study

    Su Longxiang

    2012-07-01

    Full Text Available Abstract Background The purpose of this study was to explore the diagnostic value of soluble triggering receptor expressed on myeloid cells 1 (sTREM-1, procalcitonin (PCT, and C-reactive protein (CRP serum levels for differentiating sepsis from SIRS, identifying new fever caused by bacteremia, and assessing prognosis when new fever occurred. Methods We enrolled 144 intensive care unit (ICU patients: 60 with systemic inflammatory response syndrome (SIRS and 84 with sepsis complicated by new fever at more than 48 h after ICU admission. Serum sTREM-1, PCT, and CRP levels were measured on the day of admission and at the occurrence of new fever (>38.3°C during hospitalization. Based on the blood culture results, the patients were divided into a blood culture-positive bacteremia group (33 patients and blood culture-negative group (51 patients. Based on 28-day survival, all patients, both blood culture-positive and -negative, were further divided into survivor and nonsurvivor groups. Results On ICU day 1, the sepsis group had higher serum sTREM-1, PCT, and CRP levels compared with the SIRS group (P P Conclusions Serum sTREM-1, PCT, and CRP levels each have a role in the early diagnosis of sepsis. Serum sTREM-1, with the highest sensitivity and specificity of all indicators studied, is especially notable. sTREM-1, PCT, and CRP levels are of no use in determining new fever caused by bacteremia in ICU patients, but sTREM-1 levels reflect the prognosis of bacteremia. Trial registration ClinicalTrial.gov identifier NCT01410578

  3. Procalcitonin increase in early identification of critically ill patients at high risk of mortality

    Jensen, Jens Ulrik; Heslet, L; Jensen, TH;

    2006-01-01

    OBJECTIVE: To investigate day-by-day changes in procalcitonin and maximum obtained levels as predictors of mortality in critically ill patients. DESIGN: Prospective observational cohort study. SETTING:: Multidisciplinary intensive care unit at Rigshospitalet, Copenhagen University Hospital, a...... tertiary reference hospital in Denmark. PATIENTS: Four hundred seventy-two patients with diverse comorbidity and age admitted to this intensive care unit. INTERVENTIONS: Equal in all patient groups: antimicrobial treatment adjusted according to the procalcitonin level. MEASUREMENTS AND MAIN RESULTS: Daily...... procalcitonin measurements were carried out during the study period as well as measurements of white blood cell count and C-reactive protein and registration of comorbidity. The primary end point was all-cause mortality in a 90-day follow-up period. Secondary end points were mortality during the stay in the...

  4. Use of a semiquantitative procalcitonin kit for evaluating severity and predicting mortality in patients with sepsis

    Kenzaka T

    2012-05-01

    mortality in septic patients. Based on the level of semiquantitative procalcitonin measured in patients with suspected sepsis, a timely decision can be reliably made to transfer them to a tertiary hospital with an intensive care unit for optimal care.Keywords: sepsis, semiquantitative procalcitonin, Sequential Organ Failure Assessment, Acute Physiology and Chronic Health Evaluation II, mortality, procalcitonin

  5. Clinical Significance of Dynamic Determination of Serum Procalcitonin Levels in Patients with Malignant Tumor in ICU%动态监测ICU恶性肿瘤患者血清降钙素原水平的临床意义

    张爱敏; 张鹏

    2011-01-01

    探讨血清降钙素原(procalcitonin,PCT)测定在重症监护病房(intensive care unit,ICU)恶性肿瘤患者感染的早期诊断、鉴别诊断和临床治疗中的意义.选择85例恶性肿瘤患者,其中感染组55例,非感染对照组30例.在拟诊感染的第一天,抽静脉血做血培养,同时采用半定量固相免疫色谱法(PCT-Q)检测血清PCT浓度.并根据PCT结果指导临床使用抗生素,动态监测PCT水平,观察3~7天的疗效.结果显示,血清PCT浓度在感染组与对照组间差别有统计学意义(P<0.01),PCT-Q 检测,PCT>0.5ng/mL可早期预测恶性肿瘤患者感染,其灵敏度为90.9%,特异度为96.7%.对PCT阳性患者使用适当抗生素治疗3~7天后,PCT转为正常(<0.5ng/mL).PCT-Q法较普通血培养法灵敏( P<0.01),对ICU危重恶性肿瘤患者感染早期诊断、鉴别诊断及临床抗生素治疗有指导意义.%To explore the clinical significance of determination of serum procalcitonin (PCT) levels in the early diag nosis and differential diagnosis and clinical treatment in patients with malignant tumor and infections in ICU. 85 ca ses were divided into two groups:55 patients with infection and 30 patients with no infection. Blood culture and PCT were evaluated at onset of signs of infection. PCT levels in serum were investigated by semi-quantitative solid-phase immune chromatography. The antibacterial agents were used according to the results of PCT. The curative effects were evaluated until one week. The results showed that there were statistically different (P <0.01) between infection group and no infection group in PCT levels. The PCT serum level greater than 0.5ng/mL predicted an infection and with a sensitivity of 90.9% and specificity of 96.7%. The method of PCT-Q was more sensitive than the blood cul ture(P <0.01). PCT values returned to normal(<0.5ng/mL)by 3 to 7 days of appropriate antibiotic therapy. The method of PCT-Q is more sensitive for early diagnosis of pathogens

  6. Comparing the Morphological Changes in Burn Wound Tissues and the Procalcitonin Concentration

    Ludmila I. Budkevich, PhD, ScD²

    2013-03-01

    Full Text Available The problem of early diagnostics of bacterial complications is particularly true for children with extensive burn trauma (BT. Procalcitonin concentration levels considerably facilitate the diagnosis of sepsis. In all, 50 children with severe burns were included in our research. We conducted histological tests of the burn wound tissues from 13 patients. On comparison of the results of the PCT-tests with the results of the morphological investigation, we observed that the depth of the penetration of the microorganisms in the damaged tissues quite precisely corresponded to changes in the procalcitonin concentration.

  7. Evapotranspiration Partitioning and Response to Abnormally Low Water Levels in a Floodplain Wetland in China

    Xiaosong Zhao

    2016-01-01

    Full Text Available Evapotranspiration (ET is an important component of the wetland water budget. Water level declines in Poyang Lake, the largest freshwater lake in China, have caused concerns, especially during low water levels. However, how wetland ET and its partitioning respond to abnormally low water levels is unclear. In this study, wetland ET was estimated with MODIS data and meteorological data. The wetland ET partitioning and its relationship with abnormally low water levels were analyzed for 2000–2013. The results showed that the water evaporation rate (Ewater was larger than the land ET rate (ETland; the ETland/Ewater ranged from 0.77 to 0.99. When the water level was below 12.8 m, the ET partition ratio was larger than 1, which indicates that wetland ET comes from land surface ET more than water evaporation. The negative standardized water level index (SWI was used to represent an abnormally low water level in the wetland. Although the monthly wetland ET decreased as the negative SWI decreased, ETland was higher than the average under negative SWI conditions from September to December, when the water level decreased. The abnormally low water level induced more water loss from the land surface, especially when the water level decreased, which reduced the available water resources along the wetland shore.

  8. Research on the relation between changes of serum procalcitonin level and abdominal infection%血清降钙素原水平变化与腹腔感染的关系研究

    苏宏; 蔡慧云; 于波; 白雪; 魏晓军; 聂玉辉

    2011-01-01

    Objective To analyze the relation between changes of serum procalcitonin (PCT) level and abdominal infection.Methods Serum levels of PCT were detected in 58 cases of abdominal infection.And comparative analysis of PCT levels was performed between general and severe abdominal infection groups.Results In the general infection group of 25 cases, serum PCT was ( 15.88 ±6.67) μg/L, and in the severe group of 33 cases, serum PCT was (69.83 ± 17.82) μg/L.Serum PCT of general infection group was significant higher than that of severe group ( P < 0.05 ).There were a significant positive correlation between PCT level and the APACHE- Ⅱ score in the severe group ( r = 0.791, P < 0.05 ).Pyemia occurred in 8 cases, of which PCT levels exceeded 70μ g/L, and three dead, whose PCT levels over 90μg/L.Conclusion Detecting serum PCT levels were helpful to assess the efficacy and the prognosis in patients with abdominal infection.%目的 探讨血清降钙素原(PCT)水平与腹腔感染的关系.方法 检测58例腹腔感染患者血PCT水平,对比分析一般感染组与重症感染组PCT水平.结果 一般感染组25例,PCT为(15.88 ± 6.67)μg/L.重症感染组33例,PCT为(69.83 ± 17.82)μg/L.重症感染组PCT水平显著高于一般感染组(P<0.05).对比分析重症感染组患者PCT水平与APACHE-Ⅱ评分呈正相关(r=0.791,P<0.05).重症感染组有8例出现脓毒血症,血PCT水平均>70 μg/L,3例死亡患者血PCT水平>90 μg/L.结论 对腹腔感染患者,监测血PCT变化,对评估疗效和预后有重要意义.

  9. Diagnostic value of procalcitonin for acute complicated appendicitis

    Yamashita, Hiromasa; Yuasa, Norihiro; Takeuchi, Eiji; Goto, Yasutomo; Miyake, Hideo; Miyata, Kanji; Kato, Hideki; Ito, Masafumi

    2016-01-01

    ABSTRACT A rapid and reliable test for detection of complicated appendicitis would be useful when deciding whether emergency surgery is required. We investigated the clinical usefulness of procalcitonin for identifying acute complicated appendicitis. We retrospectively analyzed 63 patients aged ≥15 years who underwent appendectomy without receiving antibiotics before admission and had preoperative data on the plasma procalcitonin level (PCT), body temperature (BT), white blood cell count (WBC), neutrophil / lymphocyte ratio (N/L ratio), and C-reactive protein level (CRP). Patients were classified into 3 groups: group A (inflammatory cell infiltration of the appendix with intact mural architecture), group B (inflammatory cell infiltration with destruction of mural architecture, but without abscess or perforation), and group C (macroscopic abscess and/or perforation). For identifying destruction of mural architecture, the diagnostic accuracy of PCT was similar to that of BT or CRP. However, the diagnostic accuracy of PCT was highest among the five inflammatory indices for identifying abscess and/or perforation, with the positive predictive value of PCT for abscess and/or perforation being higher than that of CRP (73% vs. 48%). Univariate analysis of the predictors of abscess and/or perforation revealed that a plasma PCT level ≥0.46 ng/mL had the highest odds ratio (30.3 [95% confidence interval: 6.5–140.5] versus PCT <0.46 ng/mL). These findings indicate that procalcitonin is a useful marker of acute appendicitis with abscess and/or perforation. PMID:27019529

  10. [Serum procalcitonin and respiratory tract infections].

    Zarka, V; Valat, C; Lemarié, E; Boissinot, E; Carré, P; Besnard, J C; Diot, P

    1999-12-01

    The aim of our study was to evaluate the prognostic value of serum procalcitonine (PCT) assay in adult respiratory infections. Forty-nine patients admitted with pleurisy, community-acquired pneumonia, tuberculosis, infection were included in this prospective study. PCT was assayed on admission and discharge. Biological and clinical parameters of gravity were also evaluated. Twenty patients had elevated PCT of more than 0.50 ng/ml. In 29 patients, PCT was undetectable. The serum PCT level was normal in the patients with tuberculosis, infection, pneumocytosis. PCT did not correlate with the biological and clinical markers of the disease severity but the evolution of PCT correlated with the evolution of C-reactive-protein (r = 0.58, p < 0.05). PCT seems to be an early marker of the evolution of respiratory infections, but it does not help to establish prognosis. Further studies are necessary to assess the potential value of PCT in more severe respiratory infections requiring assisted ventilation. PMID:10685471

  11. Synergistic effects of elevated homocysteine level and abnormal blood lipids on the onset of stroke

    Lu Hao; Zhenzhen Cheng; Qiang Wu; Shuzhang Li; Liming Chen; Xiaoyong Sai; Zhefeng Liu; Guang Yang; Rongzeng Yan; Lili Wang; Caiyun Fu; Xuan Xu

    2013-01-01

    Hyperhomocysteinemia and abnormal blood lipids are independent risk factors for stroke. However, whether both factors exert a synergistic effect in the onset of stroke remains unclear. The present study is a retrospective analysis of 2 089 cases of stroke and 2 089 control cases of simple inter-vertebral disk protrusion using a paired multivariate logistic regression method. Adjusting for known confounding variables including the patients’ age, gender, smoking status, alcohol consumption status, patient and family medical history, and clinical biochemical indices, elevated homocysteine level was related to the onset of stroke. Patients with elevated homocysteine levels and abnormal blood lipids showed a 40.9%increase in the risk for stroke compared to patients with normal ho-mocysteine levels and blood lipids (odds ratio 1.409;95%confidence interval 1.127-1.761). These results indicate that elevated homocysteine and abnormal blood lipids exert synergistic effects in the onset of stroke. Patients with elevated homocysteine levels and abnormal blood lipids are predis-posed to stroke.

  12. Retrospective study on prognostic importance of serum procalcitonin and amino - terminal pro - brain natriuretic peptide levels as compared to Acute Physiology and Chronic Health Evaluation IV Score on Intensive Care Unit admission, in a mixed Intensive Care Unit population

    Chitra Mehta; Babita Dara; Yatin Mehta; Tariq, Ali M.; George V Joby; Singh, Manish K

    2016-01-01

    Background: Timely decision making in Intensive Care Unit (ICU) is very essential to improve the outcome of critically sick patients. Conventional scores like Acute Physiology and Chronic Health Evaluation (APACHE IV) are quite cumbersome with calculations and take minimum 24 hours. Procalcitonin has shown to have prognostic value in ICU/Emergency department (ED) in disease states like pneumonia, sepsis etc. NTproBNP has demonstrated excellent diagnostic and prognostic importance in cardiac d...

  13. 血清降钙素原水平在尿路感染中的定位作用研究%Study on Orientating Function of Serum Procalcitonin Level in Urinary Tract Infection

    彭凯丰; 周志芳

    2012-01-01

    目的 探讨血清降钙素原(PCT)在尿路感染中的定位作用.方法 选取尿路感染患者106例,同期健康体检者100例,用化学发光免疫法测定血清中的PCT和C-反应蛋白(CRP)水平,同时检测患者外周血白细胞计数(WBC).结果 上尿路感染组患者血清PCT水平明显高于下尿路感染患者组(P<0.01),PCT对上尿路感染诊断的敏感性为81.1%,特异性为85.5%,阳性预测值为80.3%,阴性预测值为92.5%,均高于CRP和WBC.结论 血清PCT水平的测定对尿路感染有定位作用.%Objective To explore the location role of serum procalcitonin (PCT) in the diagnosis of urinary tract infection (UTI). Methods One hundred and six patients with urinary tract infection and 100 health examinees were enrolled in this study. The serum PCT and C- reactive protein (CRP) levels were measured by chemiluminescent immunoassay; meanwhile, peripheral white blood cells were counted. Results The serum level of PCT in upper urinary tract infection group was significantly higher than that in lower urinary tract infection group (P<0.01). The sensitivity and specificity of PCT in diagnosis of upper urinary tract infection were 81.1% and 85.5% respectively, positive predictive value was 80.3% and negative predictive value was 92.5 % , which were all higher than CRP and WBC. Conclusions The serum level of PCT can be used as a marker to differentially diagnose the upper and lower urinary tract infections.

  14. 急性胰腺炎大鼠血和组织中降钙素原水平的变化%Levels of procalcitonin in blood and tissue of acute pancreatitis rats

    李红昌; 韩天权; 汤耀卿; 张圣道; 雷若庆; 许志伟; 王庆刚; 柴春宇; 邓漾; 吴旭波; 武钧; 陈胜

    2010-01-01

    目的 观察急性胰腺炎(AP)大鼠血和组织中降钙素原(procalcitonin,PCT)水平的变化,并探讨其意义.方法 将102只雄性Wistar大鼠按数字表法随机分为正常对照组(6只)、脂多塘(LPS)组(24只)、急性水肿性胰腺炎(AEP)组(24只)、急性坏死性胰腺炎(ANP)组(24只)和ANP+LPS组(24只).皮下注射雨蛙素制备AEP模型,逆行胆胰管注射牛磺胆酸钠制备ANP模型.术后3、6、18、24 h分批处死动物,胰腺组织常规病理检查并评分;取血检测PCT水平;取肝、肺、脾、胰腺、小肠及大肠组织检测PCT含量.结果 AEP和ANP模型制备成功.术后6 h时,对照组、LPS组、AEP组、ANP组和ANP+LPS组血PCT水平分别为(0.0144±0.0082)ng/ml、(0.1722±0.0449)ng/ml、(0.4751±0.0572)ng/ml、(0.7070±0.1040)ng/ml和(1.1960±0.8644)ng/ml,各组间相差显著(P<0.05).正常大鼠肝、肺、脾、胰腺、小肠及大肠组织均检测到PCT.与之相比,ANP组肝和胰腺PCT含量无明显变化;肺、脾及大肠PCT含量显著降低[分别为(5.63±0.62)ng/ml对(6.85±0.46)ng/ml,(4.73±1.27)ng/ml对(6.88±0.31)ng/ml,(1.08±0.52)ng/ml对(4.12±1.02)ng/ml,P值均<0.01],而小肠组织明显升高[(2.51±0.90)ng/m1对(0.98±0.20)ng/ml,P<0.01].结论 血清PCT水平与AP的严重程度及感染相关,AP时各组织PCT含量的不同变化可能与器官功能的改变有一定的关系.%Objective To investigate the variation of procalcitonin(PCT) in blood and tissue level of acute pancreatitis rats and probe its significant. Methods One hundred and two male Wistar rats were randomly divided into control group ( n = 6 ), lipopolysaccharide group ( LPS, n = 24 ), acute edematous pancreatitis (AEP) group ( n = 24), acute necrotizing pancreatitis (ANP) group ( n = 24), AN P + LPS group ( n = 24). Subcutaneous injection of cerulein was used for AEP induction, while ANP model was induced by retrograde injection of sodium taurocholate into the biliary and pancreatic duct. The rats were

  15. Procalcitonin implication in renal cell apoptosis induced by acute pyelonephritis in children

    Belhadj-Tahar, Hafid; Coulais, Yvon; Tafani, Mathieu; Bouissou, François

    2008-01-01

    The aim of this biomedical trial was to clarify the physiological role of procalcitonin (PCT) in renal parenchyma apoptosis and fibrosis caused by acute childhood pyelonephritis. This prospective study enrolled 183 children. All children were treated with bi-therapy according to the French consensus on acute pyelonephritis treatment dated November 16, 1990: intra-vascular administration of ceftriaxone 50 mg/kg/day and netromicine 7 mg/kg/day during the first 48 hours, followed by specific antibiotherapy suited to antibiogram. On admission, PCT, C-reactive protein, and phospholipase A2 were quantified in serum. Scintigraphy monitoring with 99mTc-DMSA was performed on day 4 and 9 months later, in the presence of persistent abnormalities. On day 4, 78% presented renal parenchyma alterations and 30% renal fibrosis 9 months after admission. Paradoxically, PCT level was significantly lower in the presence of renal fibrosis due to cell apoptosis (4.19 vs 7.59 μgL−1). A significant increase in PCT indicated favorable progress (recovery 7.55 vs aggravation 3.34) and no difference between recovery and improvement. This result suggests the protective effect of PCT against apoptosis by nitric oxide down-regulation. PMID:21694876

  16. IMPORTANCE OF SERUM PROCALCITONIN IN FEBRILE NEUTROPENIA

    Mohd. Riyaz

    2014-07-01

    Full Text Available Febrile neutropenia is defined as a fever >101°F for 1 hour, with an absolute neutrophil count of ≤500 cells/microliter, or an ANC of ≤1000 cells/microliter with a projected nadir of ≤500 cells/microliter. In haematological malignancies it is the common complication and requires broad-spectrum antibacterial therapy. Clinical examination and cultures fail to detect a pathogen or an infectious focus in 25–50%, which are classified as pyrexia of unknown origin (PUO. Patient with pyrexia of unknown origin may receive long duration of antibiotic treatment as the cause is unclear of being infective or not. Febrile neutropenia is a common complication of many chemotherapeutic regimens for all types of cancers. Mortality and Morbidity is high particularly in elderly, immuno-compromised. Approximately 20- 40 % of patients with severe sepsis and 45-60% patients with septic shock die within 15-20 days. This study was done to know the sources of infection and to assess the diagnostic value of serum Procalcitonin and its relation with mortality in various stages of sepsis. Sepsis incidence was more in patient age more than 55yrs. the most common source of sepsis was respiratory tract infection. Serum PCT proved to be an indicator of sepsis in ill patients, with sensitivity of 91%. Presence of both persistent and profound neutropenia was associated with a much higher mortality. The occurrence of infection is directly proportional to the degree of neutropenia, at the onset of fever the PCT levels will not be helpful for the decision to start or stop the antibacterial therapy, and a PCT value higher than 0.5ng/ml in pyrexia of unknown origin might suggest a possibility of occult infection, i.e. with lacking microbiological and clinical documentation. A delayed PCT peak higher than0.5ng/ml contributes to the early diagnosis of fungal disease.

  17. 血清降钙素原水平变化在脑梗死患者肺部感染检测中的临床价值%Detection of serum procalcitonin levels in patients with cerebral infarction and lung infection and its clinical value

    田晓; 于柏青; 李红金; 姚楠; 周盛年

    2015-01-01

    OBJECTIVE To study the change of serum procalcitonin levels in cerebral infarction patients combined with lung infection and its clinical value ,so as to provide a reference for diagnosis and treatment of cerebral infarc‐tion complicated with lung infection .METHODS Totally 100 cases of patients with cerebral infarction and lung in‐fection in our hospital from Aug .2011 to Sep .2013 were enrolled in observation group and 100 cases of healthy people received physical examination in the same period were enrolled in control group .Then procalcitonin ,C‐re‐active protein and blood routine were detected and the remission condition of clinical symptoms and signs of pa‐tients infected by bacteria were observed .SPSS18 .0 software was used for statistical analysis .RESULTS In the ob‐servation group ,the serum procalcitonin was (13 .8 ± 2 .5)μg/L ,C reactive protein level was (14 .27 ± 2 .68)mg/L ,white blood cell counted (14 .8 ± 1 .9) × 109/L ,neutrophile granulocyte ratio was (71 .4 ± 10 .4)% .These were all higher than those of control group;lymphocyte ratio were lower than control group;the positive rate of serum procalcitonin was more than those of control group .The sensitivity and specificity of procalcitonin detection were 94% and 96% separately ,which were higher than blood routine and C reaction protein detection .The levels of procalcitonin were positively correlated with cough , sputum , asthma , pulmonary rales remission time . CONCLUSION Combined detection of serum procalcitonin is an ideal auxiliary examination index for it can improve the sensitivity and specificity of diagnosis of bacterial infections in the patients with cerebral infarction and has cor‐relation with remission of clinical symptoms and signs .%目的:研究血清降钙素原水平变化在脑梗死肺部感染的检测及临床价值,为诊治脑梗死患者肺部感染提供参考。方法将2011年8月-2013年9月收治的100例脑梗死肺部感染患者

  18. Study on the changes of leptin levels in females with abnormal thyroid function

    Objective: To study the changes of leptin levels in females with abnormal thyroid function. Methods: Serum leptin levels were determined with RIA in 60 cases of hyperthyroidism, 36 cases of hypothyroidism and 30 normal controls. In patients with thyroid dysfunction and treated, serum leptin levels were again measured after completion of therapy. Results: The serum leptin levels were positively correlated to BMI in all the cases (p 0.05). The serum leptin levels in hypothyroid patients after treatment (6.77 ± 2.35 μg/L) were significantly higher than those before treatment (4.19 ± 1.84 μg/L) (p < 0.05). No obvious differences in the levels of serum leptin were observed before and after treatment in the hyperthyroid group. Conclusion: Normal thyroid hormone levels may be an important factor to achieve an adequate leptin gene expression so as to maintain an energy metabolic balance and thyroid dysfunction will influence the normal regulation of leptin

  19. The Importance of Serum Procalcitonin in Diagnosis and Treatment of Serious Bacterial Infections and Sepsis

    Mehanic, Snjezana; Baljic, Rusmir

    2013-01-01

    The clinical utility of serum procalcitonin (PCT) levels continues to evolve. PCT is regarded as a promising candidate marker for making a diagnosis and antibiotic stewardship in patients with systemic infections. The aim of this review is to summarize the current evidence for PCT in different infections and clinical settings, and to discuss the reliability of this marker when used with validated diagnostic algorithms. PMID:24511275

  20. Can Procalcitonin Be an Accurate Diagnostic Marker for the Classification of Diabetic Foot Ulcers?

    Jonaidi Jafari, Nematollah; Safaee Firouzabadi, Mahdi; Izadi, Morteza; Safaee Firouzabadi, Mohammad Sadegh; Saburi, Amin

    2014-01-01

    Background: The differentiation of infected diabetic foot ulcers (IDFU) from non infected diabetic foot ulcers (NIDFU) is a challenging issue for clinicians. Objectives: Recently, procalcitonin (PCT) was introduced as a remarkable inflammatory marker. We aimed to evaluate the accuracy of PCT in comparison to other inflammatory markers for distinguishing IDFU from NIDFU. Materials and Methods: We evaluated PCT serum level as a marker of bacterial infection in patients with diabetic foot ulcers...

  1. Procalcitonin and C-reactive protein in pericardial fluid for postmortem diagnosis of sepsis

    Schrag, Bettina; Iglesias, Katia; Mangin, Patrice; Palmiere, Cristian

    2016-01-01

    The aim of this study was to investigate the presence and concentrations of procalcitonin and C-reactive protein in pericardial fluid and compare these levels to those found in the postmortem serum obtained from the femoral blood. Two groups were formed, a sepsis-related fatalities group and a control group. Postmortem native CT scans, autopsies, histology, neuropathology and toxicology as well as other postmortem biochemistry investigations were performed in all cases. Pericardial fluid proc...

  2. Age-specific percentile-based reference curve of serum procalcitonin concentrations in Japanese preterm infants

    Noriko Fukuzumi; Kayo Osawa; Itsuko Sato; Sota Iwatani; Ruri Ishino; Nobuhide Hayashi; Kazumoto Iijima; Jun Saegusa; Ichiro Morioka

    2016-01-01

    Procalcitonin (PCT) levels are elevated early after birth in newborn infants; however, the physiological features and reference of serum PCT concentrations have not been fully studied in preterm infants. The aims of the current study were to establish an age-specific percentile-based reference curve of serum PCT concentrations in preterm infants and determine the features. The PCT concentration peaked in infants at 1 day old and decreased thereafter. At 1 day old, serum PCT concentrations in ...

  3. Changes of serum procalcitonin level and its significance in patients with traumatic brain injury%颅脑创伤患者血清降钙素原变化及其临床意义

    赵元元; 连玉峰; 顾云彪; 楼林; 卢刚

    2015-01-01

    Objective To determine the dynamic change of serum procalcitonin (PCT) level after traumatic brain injury and the rclated clinical significance.Methods Serum levels of PCT and adrenocorticotropic hormone (ATCH) in 137 patients with traumatic brain injury and 20 normal volunteers were measured by electrochemiluminescence assay.Correlation between serum PCT level and severity of traumatic brain injury was evaluated.Results Percentage of serum PCT level at low inflammatory-risk threshold detected from day 1 to day 14 after admission was descended from 80.3% to 63.5%.Meanwhile,the percentage of serum PCT level at high inflammatory-risk threshold was a rising-fall-rising trend,but the percentages of serum PCT level at median and definite inflammatory-risk thresholds showed sustained increase from 13.9% to 27.0% and 0.7% to 3.7% separately.Based on the Glasgow Coma Scale (GCS),the dynamic change of serum PCT level demonstrated a distinct bimodal pattern in severe injury group,a gradual falling after rising mode in middle injury group which was significantly and positively correlated with GCS (r =0.463,P < 0.05),and a rising-falling-slight rising tendency in minorinjury group.In addition,the GCS in each group only closely related to the positive detections of serum PCT level detected at days 3 and 7 (x2 =10.32,16.31 respectively P < 0.01).Serum ATCH level at day 1 was far higher than that at day 14 in severe injury group and was significantly higher in severe injurygroup compared with minor and middle injury groups (P < 0.01 or 0.05).Conclusions Positive serum PCT may be predictive of the traumatic brain injury and injury degree within 3-7 days after the injury.The dynamic change of serum PCT is associated with the specialized mechanism of traumatic brain injury and neuronendocrine response,and it may be a useful parameter to assess posttraumatic stress response and prognosis.%目的 探讨颅脑创伤患者血清降钙素原(PCT)的

  4. The relationship between level of procalcitonin and the prognosis of infants with sepsis%血浆降钙素原与脓毒症患儿预后的关系

    张笃飞; 冯小伟

    2007-01-01

    目的 探讨血浆降钙素原(procalcitonin,PCT)与脓毒症患儿预后的关系.方法 采用免疫发光法检测65例脓毒症患儿血浆PCT水平.结果 死亡组入院时血浆PCT水平与同期存活组相比,差异有显著性意义(P<0.05).最初3d血浆PCT水平变化与脓毒症临床不同结局密切相关.结论 血浆PCT检测对脓毒症患儿预后判断具有重要价值.

  5. Retrospective study on prognostic importance of serum procalcitonin and amino - terminal pro - brain natriuretic peptide levels as compared to Acute Physiology and Chronic Health Evaluation IV Score on Intensive Care Unit admission, in a mixed Intensive Care Unit population

    Chitra Mehta

    2016-01-01

    Full Text Available Background: Timely decision making in Intensive Care Unit (ICU is very essential to improve the outcome of critically sick patients. Conventional scores like Acute Physiology and Chronic Health Evaluation (APACHE IV are quite cumbersome with calculations and take minimum 24 hours. Procalcitonin has shown to have prognostic value in ICU/Emergency department (ED in disease states like pneumonia, sepsis etc. NTproBNP has demonstrated excellent diagnostic and prognostic importance in cardiac diseases. It has also been found elevated in non-cardiac diseases. We chose to study the prognostic utility of these markers on ICU admission. Settings and Design: Retrospective observational study. Materials and Methods: A Retrospective analysis of 100 eligible patients was done who had undergone PCT and NTproBNP measurements on ICU admission. Their correlations with all cause mortality, length of hospital stay, need for ventilator support, need for vasopressors were performed. Results: Among 100 randomly selected ICU patients, 28 were non-survivors. NTproBNP values on admission significantly correlated with all cause mortality (P = 0.036, AUC = 0.643 and morbidity (P = 0.000, AUC = 0.763, comparable to that of APACHE-IV score. PCT values on admission did not show significant association with mortality, but correlated well with morbidity and prolonged hospital length of stay (AUC = 0.616, P = 0.045. Conclusion: The current study demonstrated a good predictive value of NTproBNP, in terms of mortality and morbidity comparable to that of APACHE-IV score. Procalcitonin, however, was found to have doubtful prognostic importance. These findings need to be confirmed in a prospective larger study.

  6. Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice.

    Quan Yuan

    Full Text Available Maintenance of normal mineral ion homeostasis is crucial for many biological activities, including proper mineralization of the skeleton. Parathyroid hormone (PTH, Klotho, and FGF23 have been shown to act as key regulators of serum calcium and phosphate homeostasis through a complex feedback mechanism. The phenotypes of Fgf23(-/- and Klotho(-/- (Kl(-/- mice are very similar and include hypercalcemia, hyperphosphatemia, hypervitaminosis D, suppressed PTH levels, and severe osteomalacia/osteoidosis. We recently reported that complete ablation of PTH from Fgf23(-/- mice ameliorated the phenotype in Fgf23(-/-/PTH(-/- mice by suppressing serum vitamin D and calcium levels. The severe osteomalacia in Fgf23(-/- mice, however, persisted, suggesting that a different mechanism is responsible for this mineralization defect. In the current study, we demonstrate that deletion of PTH from Kl(-/- (Kl(-/-/PTH(-/- or DKO mice corrects the abnormal skeletal phenotype. Bone turnover markers are restored to wild-type levels; and, more importantly, the skeletal mineralization defect is completely rescued in Kl(-/-/PTH(-/- mice. Interestingly, the correction of the osteomalacia is accompanied by a reduction in the high levels of osteopontin (Opn in bone and serum. Such a reduction in Opn levels could not be observed in Fgf23(-/-/PTH(-/- mice, and these mice showed sustained osteomalacia. This significant in vivo finding is corroborated by in vitro studies using calvarial osteoblast cultures that show normalized Opn expression and rescued mineralization in Kl(-/-/PTH(-/- mice. Moreover, continuous PTH infusion of Kl(-/- mice significantly increased Opn levels and osteoid volume, and decreased trabecular bone volume. In summary, our results demonstrate for the first time that PTH directly impacts the mineralization disorders and skeletal deformities of Kl(-/-, but not of Fgf23(-/- mice, possibly by regulating Opn expression. These are significant new perceptions into

  7. Use of procalcitonin for the differential diagnosis of fever in cancer patients: an observational study

    Daria Macchioni

    2013-09-01

    Full Text Available Fever often occurs in cancer patients and the possibility of having a reliable marker for the differential etiological diagnosis is desirable. The aim of this study was to investigate the eligibility of the use of procalcitonin (PCT in hemato-oncological patients for the differential diagnosis of fever. We prospectively enrolled 98 cancer patients and divided them into two groups: those with active disease and those with non-active disease. Procalcitonin was dosed at Time 0 (recruitment and at the onset of fever. On enrollment, PCT values were 0.1 ng/mL in 83% patients with active disease, and lower than 0.5 ng/mL in 23%, which is usually considered not suggestive of bacterial infection. Four percent of patients had values over 0.5 ng/mL and these were mainly patients with neuroendocrine tumors or affiliates. On enrollment, there were also no statistically significant differences in PCT values between the two groups of patients. This showed that active cancer is unable by itself to change PCT levels. In the active disease group, 21 episodes of fever due to bacterial infection were registered, and in all of them an increase in PCT values was observed. This demonstrates the ability of PCT to detect an infection-induced fever in cancer patients. Procalcitonin concentrations are not significantly altered by active neoplastic disease. On the contrary, in the course of fever due to a bacterial infection, PCT values increase and can, therefore, be considered a useful tool in the differential diagnosis between infection-induced fever and drug-related or tumor associated-fever. Procalcitonin may be a useful marker of bacterial infection even in cancer patients.

  8. Detection of abnormalities in ultrasound lung image using multi-level RVM classification.

    Veeramani, Senthil Kumar; Muthusamy, Ezhilarasi

    2016-06-01

    The classification of abnormalities in ultrasound images is the monitoring tool of fluid to air passage in the lung. In this study, the adaptive median filtering technique is employed for the preprocessing step. The preprocessed image is then extracted the features by the convoluted local tetra pattern, histogram of oriented gradient, Haralick feature extraction and the complete local binary pattern. The extracted features are selected by applying particle swarm optimization and differential evolution feature selection. In the final stage, classifiers namely relevance vector machine (RVM), and multi-level RVM are employed to perform classification of the lung diseases. The diseases respiratory distress syndrome (RDS), transient tachypnea of the new born, meconium aspiration syndrome, pneumothorax, bronchiolitis, pneumonia, and lung cancer are used for training and testing. The experimental analysis exhibits better accuracy, sensitivity, specificity, pixel count and fitness value than the other existing methods. The classification accuracy of above 90% is accomplished by multi-level RVM classifier. The system has been tested with a number of ultrasound lung images and has achieved satisfactory results in classifying the lung diseases. PMID:26135771

  9. DYNAMICS OF PROCALCITONIN AT THE PATIENT AFTER COMBINED ORGAN TRANSPLANTATION

    M. Sh. Khubutia

    2010-01-01

    Full Text Available Case report represents two episodes of procalcitonin elevation in dynamics, connected with different induction mechanisms of this sepsis marker at the patient after combined pancreas and kidney transplantation. 

  10. Impact of Low Procalcitonin Results on Antibiotic Administration in Hospitalized Patients at a Tertiary Care Center

    Brennan, Meghan B.; Osterby, Kurt; Schulz, Lucas; Lepak, Alexander J.

    2016-01-01

    Procalcitonin is a sensitive and specific marker of bacterial infection; low results allow clinicians to safely de-escalate antibiotics. This retrospective cohort study aimed to determine the effect of low procalcitonin results on withholding, discontinuing, or de-escalating antibiotics in hospitalized patients at a tertiary care center. Antibiotics were initiated or continued without de-escalation in 55% of patients with low procalcitonin results. Among patients with low procalcitonin result...

  11. Hepatic glycogen deposition in a patient with anorexia nervosa and persistently abnormal transaminase levels.

    Kransdorf, Lisa N; Millstine, Denise; Smith, Maxwell L; Aqel, Bashar A

    2016-04-01

    Anorexia nervosa and other eating disorders characterized by calorie restriction have been associated with a variety of hepatic abnormalities. Fatty steatosis has been described in eating disorder patients. We report the rare finding of glycogen accumulation in the liver in a patient with anorexia nervosa, which to our knowledge is only the second such case reported in the literature. This case highlights the importance of monitoring for liver abnormalities in patients with restrictive eating disorders. PMID:26066296

  12. Method for the selective measurement of amino-terminal variants of procalcitonin.

    Struck, J.; Strebelow, M.; Tietz, S.; Alonso, C.; Morgenthaler, N.G.; Hoeven, J.G. van der; Pickkers, P.; Bergmann, A.

    2009-01-01

    BACKGROUND: Procalcitonin (PCT) is an established marker for diagnosing and monitoring bacterial infections. Full-length PCT [116 amino acids that make up procalcitonin (PCT1-116)] can be truncated, leading to des-Ala-Pro-PCT (des-Alanin-Prolin-Procalcitonin; PCT3-116). Current immunoassays for PCT

  13. Diagnostic Value of Procalcitonin in ANCA-Associated Vasculitis (AAV) to Differentiate Between Disease Activity, Infection and Drug Hypersensitivity

    Herrmann, K; Schinke, S; Csernok, E.; Moosig, F; Holle, J. U.

    2015-01-01

    Objective: Procalcitonin (PCT) is considered to be a specific marker for severe bacterial infections and sepsis. Elevated PCT levels have been reported in active autoimmune diseases without infection. The aim of this study was to assess the diagnostic value of PCT serum levels in ANCA-associated vasculitis (AAV) patients with respect to infection, disease activity and drug fever using a high sensitive PCT detection method. Methods: In 53 AAV patients with elevated C-reactive protein (CRP) PCT...

  14. Procalcitonin in sepsis and bacterial infections

    Abhijit Chaudhury

    2013-10-01

    Full Text Available The differentiation of sepsis and systemic bacterial infections from other causes of systemic inflammatory response is crucial from the therapeutic point of view. The clinical signs and symptoms are non-specific and traditional biomarkers like white cell count, erythrocyte sedimentation rate and C-reactive protein are not sufficiently sensitive or specific to guide therapeutic decisions. Procalcitonin (PCT is considered a reliable marker for the diagnosis and prognosis of moderate to severe bacterial infections, and it has also been evaluated to guide the clinicians in the rational usage of antibiotics. This review describes the diagnostic and prognostic role of PCT as a biomarker in various clinical settings along with the laboratory aspects and its usefulness in risk stratification and antibiotic stewardship.

  15. Negative predictive value of procalcitonin in medullary thyroid carcinoma.

    Lim, Soo Kyung; Guéchot, Jérôme; Vaubourdolle, Michel

    2016-01-01

    Calcitonin (CT), the major biochemical marker in medullary thyroid carcinoma (MTC) is prone to in vitro instability and suffers from scarcity of clinical laboratory platforms. Procalcitonin (PCT), the precursor of CT, free of these shortcomings, has been reported as a potential MTC marker. The aim of this study was to assess the negative predictive value (NPV) of PCT as a first-line marker in MTC. 476 serum samples referred to our laboratory for CT measurements were analyzed for PCT. NPVs of PCT were assessed at 3 cut-offs (0.05, 0.10 and 0.15 ng/mL) and the diagnosis of MTC was based on CT levels. PCT and CT levels were correlated (r=0.7554 for CT levels above 10 pg/mL, n=66). Accepting the CT cut-off based on the upper reference limit the NPV of PCT were 98.1% (0.05 ng/mL), 96.3% (0.10 ng/mL) and 95.4% (0.15 ng/mL) respectively. For a CT cut-off of 100 pg/mL the NPVs of PCT were 100% for all PCT thresholds. Serum PCT has a strong NPV and could be a good candidate for a first-line screening test to exclude MTC in patients with suspicious thyroid nodules or suggestive symptoms. Larger prospective studies are necessary to confirm our results. PMID:26806393

  16. Utility of blood procalcitonin concentration in the management of cancer patients with infections

    Durnaś, Bonita; Wątek, Marzena; Wollny, Tomasz; Niemirowicz, Katarzyna; Marzec, Michał; Bucki, Robert; Góźdź, Stanisław

    2016-01-01

    Diagnosis of infections in cancer patients is usually problematic since differentiating between infection and fever of unknown origin is often a considerable clinical challenge. In general, increase concentration of blood procalcitonin (PCT) is associated with severe bacterial infection. PCT with an optimal cutoff level of 0.5 ng/mL seems to be the most helpful biochemical parameter in detecting severe infections, mainly bloodstream infection, in patients with hematological cancers. In all clinical situations, the elevated level of PCT should be carefully analyzed, always with a thorough physical examination and an appropriate microbiological assessment. PMID:26858528

  17. Diagnostic approach to phlogoses: the validity of procalcitonin

    E. Dimitri

    2013-12-01

    Full Text Available Aim. The aim of our study is to compare the potential usefulness of procalcitonin with the CRP as a diagnostic marker of pediatric diseases and to define the diagnostic accuracy and relation with the inflammation etiology and severity of procalcitonin. Methods. The analysis focused on a sample of 141 children, hospitalized for fever with bacterial, viral or inflammatory etiology, studied at the time of admission in the Hospital, and after defervescence. The sensitivity, the specificity, the positive and negative predictive value have been calculated for the both tests, explained above. Results. The diagnostic accuracy of procalcitonin is the same as the one of PCR in all cases. The result of the test has been positive in 85,7% of the serious infections and has been useful to identifiy the etiology of infections in almost 2/3 of patients. Conclusion. Procalcitonin seems to be a promising marker of infections because of its following features: a larger contribution in the monitoring phase (fast positivization and normalization; the diagnostic accuracy and a good correlation with the etiology and the severity of infections. Nonetheless, the routine use of procalcitonin is not recommended in the light of

  18. A comparison of high-mobility group-box 1 protein, lipopolysaccharide-binding protein and procalcitonin in severe community-acquired infections and bacteraemia: a prospective study

    Gaïni, Shahin; Koldkjaer, Ole G; Møller, Holger J;

    2008-01-01

    immune response when the host is challenged by bacterial pathogens. Procalcitonin (PCT) has been suggested as a marker of severe bacterial infections and sepsis. The aim of the present study was to investigate levels of HMGB1, LBP and PCT in a well-characterised sepsis cohort. The study plan included...

  19. Procalcitonin and C-reactive protein-based decision tree model for distinguishing PFAPA flares from acute infections

    Barbara Kraszewska-Głomba; Zofia Szymańska-Toczek; Leszek Szenborn

    2016-01-01

    As no specific laboratory test has been identified, PFAPA (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) remains a diagnosis of exclusion. We searched for a practical use of procalcitonin (PCT) and C-reactive protein (CRP) in distinguishing PFAPA attacks from acute bacterial and viral infections. Levels of PCT and CRP were measured in 38 patients with PFAPA and 81 children diagnosed with an acute bacterial (n=42) or viral (n=39) infection. Statistical analysis with t...

  20. The analysis of correlation between serum procalcitonin concentration and microbial infectionsin patients with sepsis

    孙胜男

    2013-01-01

    Objective To investigate the diagnostic and predict value of procalcitonin (PCT) in ICU patients with sepsis and the correlation between PCT concentration and positive results of bacterial culture.Methods A total of 278patients with sepsis were admitted into emergency ICU,general ICU and respiratory ICU from October 2011 to September 2012.Of them,193 patients had definite microbial infection evidence.Serum PCT levels among groups of different pathogens were compared.The analysis of correlation between the PCT concentration of the

  1. Diagnostic and Prognostic Role of Procalcitonin in Infections

    Maria Hatzistilianou

    2010-01-01

    Full Text Available Despite several consensus conferences, the criteria for the definition of sepsis are still considered too sensitive and insufficiently specific. The traditional clinical signs of infection and routine laboratory tests used to diagnose bacterial infection and sepsis lack diagnostic accuracy and can be misleading, particularly in patients with immunodeficiencies. The problems with sepsis definitions and diagnoses are indications of the need to focus on biochemical mediators capable not only of distinguishing the inflammatory response to infection from other types of inflammation, but also of indicating the severity and prognosis of the disease. Thus, physicians need an early and rapid marker for detecting bacterial infection and distinguishing it from viral infection. Several studies revealed that elevated procalcitonin (PCT levels in human blood could be detected in cases of sepsis and bacterial infection. PCT is a protein that can act as a hormone and a cytokine. It can be produced by several cell types and many organs in response to proinflammatory stimuli, particularly bacterial infection. It provides a rapid diagnostic test, available at the patient's bedside, and its half-life is suitable for daily monitoring of the disease progress.

  2. Diagnostic Accuracy of Procalcitonin in Bacterial Meningitis Versus Nonbacterial Meningitis

    Wei, Ting-Ting; Hu, Zhi-De; Qin, Bao-Dong; Ma, Ning; Tang, Qing-Qin; Wang, Li-Li; Zhou, Lin; Zhong, Ren-Qian

    2016-01-01

    Abstract Several studies have investigated the diagnostic accuracy of procalcitonin (PCT) levels in blood or cerebrospinal fluid (CSF) in bacterial meningitis (BM), but the results were heterogeneous. The aim of the present study was to ascertain the diagnostic accuracy of PCT as a marker for BM detection. A systematic search of the EMBASE, Scopus, Web of Science, and PubMed databases was performed to identify studies published before December 7, 2015 investigating the diagnostic accuracy of PCT for BM. The quality of the eligible studies was assessed using the revised Quality Assessment for Studies of Diagnostic Accuracy method. The overall diagnostic accuracy of PCT detection in CSF or blood was pooled using the bivariate model. Twenty-two studies involving 2058 subjects were included in this systematic review and meta-analysis. The overall specificities and sensitivities were 0.86 and 0.80 for CSF PCT, and 0.97 and 0.95 for blood PCT, respectively. Areas under the summary receiver operating characteristic curves were 0.90 and 0.98 for CSF PCT and blood PCT, respectively. The major limitation of this systematic review and meta-analysis was the small number of studies included and the heterogeneous diagnostic thresholds adopted by eligible studies. Our meta-analysis shows that PCT is a useful biomarker for BM diagnosis. PMID:26986140

  3. Nerve conduction abnormalities in untreated maturity-onset diabetes: relation to levels of fasting plasma glucose and glycosylated hemoglobin.

    Graf, R J; Halter, J B; Halar, E; Porte, D

    1979-03-01

    The role of metabolic abnormalities in the development of diabetic neuropathy is controversial. To investigate the influence of hyperglycemia on nerve conduction, we studied 20 untreated maturity-onset diabetic patients and 23 normal control subjects of similar age. Nerve conduction velocity of motor (median, peroneal, and tibial) and sensory (median and sural) nerves in diabetic patients was significantly slowed and H-reflex latency time prolonged. Levels of fasting plasma glucose in diabetic subjects were correlated with slowed motor conduction velocity of the median, peroneal, and tibial nerves but not with sensory nerve conduction velocities. Levels of glycosylated hemoglobin, an index of long-term glycemia, were correlated with slowing of peroneal motor conduction velocity in diabetic patients. These associations could not be explained by patient age or duration of diabetes. These findings suggest that the degree of hyperglycemia of untreated maturity-onset diabetes contributes to the motor nerve conduction abnormalities in this disease. PMID:426398

  4. Diastolic Dysfunction Induced by a High-Fat Diet Is Associated with Mitochondrial Abnormality and Adenosine Triphosphate Levels in Rats

    Kang, Ki-Woon; Kim, Ok-Soon; Chin, Jung Yeon; Kim, Won Ho; Park, Sang Hyun; Choi, Yu Jeong; Shin, Jong Ho; Jung, Kyung Tae; Lim, Do-Seon; Lee, Seong-Kyu

    2015-01-01

    Background Obesity is well-known as a risk factor for heart failure, including diastolic dysfunction. However, this mechanism in high-fat diet (HFD)-induced obese rats remain controversial. The purpose of this study was to investigate whether cardiac dysfunction develops when rats are fed with a HFD for 10 weeks; additionally, we sought to investigate the association between mitochondrial abnormalities, adenosine triphosphate (ATP) levels and cardiac dysfunction. Methods We examined myocardia...

  5. Serum Procalcitonin and Procalcitonin Clearance as a Prognostic Biomarker in Patients with Severe Sepsis and Septic Shock

    Min-Yi Huang

    2016-01-01

    Full Text Available We evaluated the tendency of the plasma concentration and procalcitonin (PCT clearance (PCTc to act as biomarkers of prognosis in patients with severe sepsis and septic shock. From 2011 to 2013, we prospectively analyzed patients with sepsis admitted to the intensive care unit (ICU. The serum PCT was evaluated at the time of sepsis diagnosis and again after 48 h (day 3 and 96 h (day 5. PCTc after 48 h (PCTc-day 3 and 96 h (PCTc-day 5 was also calculated to evaluate the prognostic value for survival in patients with sepsis. A total of 48 patients were included. Overall mortality was 16.7% (8 patients. PCTc was higher in survivors than in nonsurvivors, with significant differences on day 3 and day 5 (p=0.033; p=0.002, resp.; however, serum PCT levels on day 1, day 3, and day 5 were not significant prognostic factors for survival. The prognosis of patients with severe sepsis and septic shock may be associated with PCTc. Dynamic changes of PCT reflected as PCTc at 48 h (day 3 and 96 h (day 5 after admission to the ICU may serve as a predictor of survival in critically ill patients with severe sepsis.

  6. Serum Procalcitonin and Procalcitonin Clearance as a Prognostic Biomarker in Patients with Severe Sepsis and Septic Shock

    Huang, Min-Yi; Chen, Chun-Yu; Chien, Ju-Huei; Wu, Kun-Hsi; Chang, Yu-Jun; Wu, Han-Ping

    2016-01-01

    We evaluated the tendency of the plasma concentration and procalcitonin (PCT) clearance (PCTc) to act as biomarkers of prognosis in patients with severe sepsis and septic shock. From 2011 to 2013, we prospectively analyzed patients with sepsis admitted to the intensive care unit (ICU). The serum PCT was evaluated at the time of sepsis diagnosis and again after 48 h (day 3) and 96 h (day 5). PCTc after 48 h (PCTc-day 3) and 96 h (PCTc-day 5) was also calculated to evaluate the prognostic value for survival in patients with sepsis. A total of 48 patients were included. Overall mortality was 16.7% (8 patients). PCTc was higher in survivors than in nonsurvivors, with significant differences on day 3 and day 5 (p = 0.033; p = 0.002, resp.); however, serum PCT levels on day 1, day 3, and day 5 were not significant prognostic factors for survival. The prognosis of patients with severe sepsis and septic shock may be associated with PCTc. Dynamic changes of PCT reflected as PCTc at 48 h (day 3) and 96 h (day 5) after admission to the ICU may serve as a predictor of survival in critically ill patients with severe sepsis. PMID:27088084

  7. Procalcitonin and other acute phase reactants in patients with chronic obstructive pulmonary disease exacerbation

    Cemil Civelek

    2011-06-01

    Full Text Available The aim of this study was to investigate the correlation between procalcitonin and other acute phase reactants, and also analyze their relationship with clinical situation in chronic obstructive pulmonary disease (COPD acute exacerbations.Materials and methods: The study was made with 122 acute COPD exacerbated patients, who were admitted to emergency service. Patients with below 0.25 ng/ml PCT value included Group 1, and the patients with PCT values ≥ 0.25 ng/ml Group 2. Serum procalcitonin levels, erythrocyte sedimentation rate (ESR, C-reactive protein (CRP values and white blood cell (WBC counts were measured. Also, patients hospitalization time and mortality rates were recorded and compared with PCT.Results: Patients were divided in 3 groups according to their clinical diagnosis; Pneumonia (n=27, Mycoplasma-Chlamydia pneumonia (n=11 and the patients with only COPD exacerbation(n=84. Mean PCT values according to the groups were 9.47 ± 8.1 ng/ml, 0.41 ± 0.2 ng/ml, and 0.21 ± 0.05 ng/ml respectively. The relationship between PCT with CRP and white blood cell has been found between significiant (p=0.001, p=0.005 respectively, whereas the relationship between PCT and ESR was nonsignificant (p=0.55. Procalcitonin and CRP had a positive correlation with the hospitalization time (p=0.034, p=0.022 respectively. The mean ± standard error of PCT for the patients who died was 28.3 ± 27.5 ng/ml, and the difference between patients who died or were discharged was statistically significant (p= 0.012.Conclusion: PCT can be a useful indicator for morbidity and prognosis in COPD patients.

  8. 降钙素原在重症肺炎中的临床应用%Application value of procalcitonin in severe pneumonia

    李敏莉; 毛蓓; 袁蓓

    2015-01-01

    Objective To understand the diagnostic value of procalcitonin in severe pneumonia. Methods A total of 46 severe pneumonia patients were selected as experimental group, and 46 healthy people at the same period were chosen as control group. They all received blood routine examination, detection of C-reactive protein, procalcitonin, and body temperature within 1 d. The experimental group was classified by procalcitonin level (as≥10.0μg/L group,0.05). The level of procalcitonin had a correlation with hospital stays, application times of breathing machine, and antibiotics use times of the severe pneumonia patients (P0.05);降钙素原水平与重症肺炎患者住院时间、呼吸机应用次数、抗生素使用时间具有相关性(P<0.05)。结论降钙素原在重症肺炎临床诊断与病情评估中具有重要的指导价值,在临床上应引起足够重视。

  9. [The value of quantitative analysis of procalcitonine in diagnostics of septic complications in patients with autoimmune rheumatic diseases].

    Lapin, S V; Maslianskiĭ, A L; Lazareva, N M; Vasil'eva, E Iu; Totolian, A A

    2013-01-01

    The infections very often complicate the course of autoimmune rheumatic diseases. In diagnostic of septic complications in rheumatic patients the new biomarkers of infections can have a decisive importance. The procalciotonine test is one of them. The issue was to evaluate the diagnostic informativity of this test. The sample included 93 patients. The examination was applied to 65 patients with rheumatic diseases. Among them, 13 patients had bacterial infections. The group consisted of 33 patients with rheumatoid arthritis, 11 patients with systemic lupus erythematous, 6 patients with systemic angiitis, and 15 patients with other rheumatic diseases. The comparative group included 27 patients of cardio-therapeutic profile and 8 of these patients had bacterial infections. The procalcitonine test was applied with quantitative electrochemiluminescent technique. In patients with rheumatoid arthritis the mean levels of procalciotonine test consisted 0.10 +/- 0.13 ng/ml; with systemic lupus erythematous--0.08 +/- 0.06 ng/ml; with systemic angiitis--0.22 +/- 0.2 ng/ml; with other rheumatic diseases--0.12 +/- 0.15 ng/ml; of cardio-therapeutic profile without infections--0.08 +/- 0.06 ng/vl/ With threshold of procalcitonine test higher than 0.5/ml the sensitivity to diagnostic of infections consisted of 58%, specificity--94% in the group with rheumatic diseases. The procalciotonine test in case of no infection process with values higher than 0.5 ng/ml was detected in three patients. The evaluation of dependence of sensitivity and specificity for procalciotonine test and C-reactive protein the area under curve of procalcitonine test was larger in patients with rheumatic diseases (0.85 against 0.79) and in patients of cardio-therapeutic profile (0.92 against 0.90). The quantitative procalcitonine test is the best technique to detect septic complications in rheumatic patients. PMID:23807991

  10. Procalcitonin kinetics – prognostic and diagnostic significance in septic patients

    Mierzchała-Pasierb, Magdalena; Durek, Grażyna

    2016-01-01

    Introduction Severe sepsis and septic shock are advanced clinical conditions representing the patient's response to infection and having a variable but high mortality rate. Early evaluation of sepsis stage and choice of adequate treatment are key factors for survival. Some study results suggest the necessity of daily procalcitonin (PCT) monitoring because of its prognostic and discriminative value. Material and methods An observational and prospective study was conducted to evaluate the prognostic and discriminative value of PCT kinetics in comparison to PCT absolute value measurements. In a group of 50 intensive care unit patients with diagnosis of severe sepsis or septic shock, serum PCT measurements were performed on admission, and on the 2nd, 3rd and 5th day of therapy. The level of PCT was determined with a commercially available test according to the manufacturer's protocol. Results The kinetics of PCT assessed by ΔPCT was statistically significant in the survivors vs. the non-survivors subgroup (ΔPCT3/1, p = 0.022; ΔPCT5/1, p = 0.021). ΔPCT has no statistical significance in the severe sepsis and septic shock subgroups for all analyzed days. Only the 5th day PCT level was significantly higher in the non-survivors vs. survivors group (p = 0.008). The 1st day PCT level in the severe sepsis vs. septic shock group has a discriminative impact (p = 0.009). Conclusions According to the results, single serum PCT measurement, regardless of absolute value, has a discriminative impact but no prognostic significance, during the first 2 days of therapy. The PCT kinetics is of prognostic value from the 3rd day and is of earlier prognostic significance in comparison to changes in the patient's clinical condition evaluated by SOFA score kinetics. PMID:26925126

  11. Utility of blood procalcitonin concentration in the management of cancer patients with infections

    Durnaś B

    2016-01-01

    Full Text Available Bonita Durnaś,1,2 Marzena Wątek,1 Tomasz Wollny,1 Katarzyna Niemirowicz,3 Michał Marzec,4 Robert Bucki,2,3 Stanisław Góźdź1 1Holy Cross Oncology Center of Kielce, Artwinskiego, Kielce, Poland; 2Department of Physiology, Pathophysiology and Microbiology of Infections, The Faculty of Health Sciences of the Jan Kochanowski University in Kielce, Aleja IX Wieków Kielc, Kielce, Poland; 3Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok, Bialystok, Poland; 4Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA Abstract: Diagnosis of infections in cancer patients is usually problematic since differentiating between infection and fever of unknown origin is often a considerable clinical challenge. In general, increase concentration of blood procalcitonin (PCT is associated with severe bacterial infection. PCT with an optimal cutoff level of 0.5 ng/mL seems to be the most helpful biochemical parameter in detecting severe infections, mainly bloodstream infection, in patients with hematological cancers. In all clinical situations, the elevated level of PCT should be carefully analyzed, always with a thorough physical examination and an appropriate microbiological assessment. Keywords: procalcitonin, cancer, infection

  12. Diagnostic value of procalcitonin in acutely hospitalized elderly patients.

    Steichen, O; Bouvard, E; Grateau, G; Bailleul, S; Capeau, J; Lefèvre, G

    2009-12-01

    The aim of this study was to evaluate procalcitonin as an adjunct to diagnose bacterial infections in older patients. One hundred seventy-two patients admitted to an acute-care geriatric unit during a 6-month period were prospectively included, 39 of them with an invasive bacterial infection. The best cut-off value to rule in a bacterial infection was 0.51 microg/l with sensitivity 64% and specificity 94%. The best cut-off value to rule out a bacterial infection was 0.08 microg/l with sensitivity 97% and specificity 20%. Procalcitonin was inconclusive (between 0.08 and 0.51 microg/l) for 112 admissions. Procalcitonin over 0.51 microg/l was useless 22 times out of 33 (infection already ruled in on clinical grounds) and misleading in eight of the 11 remaining cases (no infection). Procalcitonin below 0.08 microg/l was useless 23 times out of 27 (infection already ruled out on clinical grounds) and misleading in one of the four remaining cases (infection). Despite a good overall diagnostic accuracy, the clinical usefulness of PCT to diagnose invasive bacterial infections in elderly patients hospitalized in an acute geriatric ward appears to be very limited. PMID:19727867

  13. Can delayed time to referral to a tertiary level urologist with an abnormal PSA level affect subsequent Gleason grade in the opportunistically screened population?

    O'Kelly, Fardod

    2013-09-01

    There is growing conflict in the literature describing the effect of delayed treatment on outcomes following radical prostatectomy. There is also evidence to suggest progression of low-risk prostate cancer to develop higher grades and volumes of prostate cancer during active surveillance. It is unknown as to what affect a delay in referral of those men with abnormal screened-PSA levels have on subsequent Gleason grade.

  14. Analysis of serum lipid profiles, metal ions and thyroid hormones levels abnormalities in - thalassaemic children of Bangladesh

    Objective: To assess the serum lipid profile of cardiovascular disease free male and female children with - thalassaemia. Levels of zinc, copper and magnesium in the serum were also determined along with the Thyroid profile. Methods: From January to December 2007, we enrolled 121 consecutive patients with -thalassaemia that visited The Thalassaemia Center at Dhaka Shishu (Children) Hospital, Bangladesh every month for routine examinations. Fasting blood lipid levels were measured in all participants. Zinc, Copper and Magnesium levels in serums were determined. Thyroid function was also assessed by evaluating T3, T4 and TSH levels. Results: Of the 121 patients, 65 were males (10.14 +- 3.91 years) and 56 were females (9.08 +- 4.32 years). Data analysis revealed that 2.0% males and 4.35% females had high total serum cholesterol, and 28.57% males and 21.74% females had high triglyceride levels. In addition, mean HDL-cholesterol levels were 21.14 +- 5.82 mg/dl in males and 21.17 +- 6.02 mg/dl in females; total-cholesterol to HDL-cholesterol ratios were 5.47 +- 1.66 and 5.96 +- 2.81 in males and females respectively. About 60% patients showed low serum level of Zn and Cu. Hypothyroidism was detected in 30% patients and 23% patients had abnormal experimental values of all the study parameters. Conclusions: The majority of the patients had blood lipid levels (by the exception of HDL-cholesterol) within the normal range, and consequently the prevalence of lipid abnormalities was much lower as compared to the general population of the same age. Interestingly, the total-cholesterol to HDL-cholesterol ratio was high in our patients, and may underline the importance of this index for the prognosis of future cardiac events in these patients. The serum Zn and Cu levels were low in most of the patients which may cause some metabolic abnormalities in future. Most of the patients also showed hypothyroidism indicating the presence of endocrine complications. (author)

  15. Procalcitonin as an adjunctive biomarker in sepsis

    Mahua Sinha

    2011-01-01

    Full Text Available Sepsis can sometimes be difficult to substantiate, and its distinction from non-infectious conditions in critically ill patients is often a challenge. Serum procalcitonin (PCT assay is one of the biomarkers of sepsis. The present study was aimed to assess the usefulness of PCT assay in critically ill patients with suspected sepsis. The study included 40 patients from the intensive care unit with suspected sepsis. Sepsis was confirmed clinically and/or by positive blood culture. Serum PCT was assayed semi-quantitatively by rapid immunochromatographic technique (within 2 hours of sample receipt. Among 40 critically ill patients, 21 had clinically confirmed sepsis. There were 12 patients with serum PCT ≥10 ng/ml (8, blood culture positive; 1, rickettsia; 2, post-antibiotic blood culture sterile; and 1, non-sepsis; 7 patients with PCT 2-10 ng/ml (4, blood culture positive; 1, falciparum malaria; 2, post-antibiotic blood culture sterile; 3 patients with PCT of 0.5 to 2 ng/ml (sepsis in 1 patient; and 18 patients with PCT < 0.5 ng/ml (sepsis in 2 patients. Patients with PCT ≥ 2 ng/ml had statistically significant correlation with the presence of sepsis (P<0.0001. The PCT assay revealed moderate sensitivity (86% and high specificity (95% at a cut-off ≥ 2 ng/ml. The PCT assay was found to be a useful biomarker of sepsis in this study. The assay could be performed and reported rapidly and provided valuable information before availability of culture results. This might assist in avoiding unwarranted antibiotic usage.

  16. Serum vitamin A levels and associated abnormalities in patients on regular dialysis treatment.

    Werb, R; Clark, W F; Lindsay, R M; Jones, E O; Linton, A L

    1979-08-01

    Multivitamin preparations are commonly administered to regular dialysis treatment (RDT) patients. Serum Vitamin A was measured in 72 patients on RDT. Elevated serum Vitamin A levels (102.29 +/- 26.95 microgram/dl [3.57 +/- 0.94 mumoles/l]) were found in the dialysis population (normal 40.98 +/- 6.71 microgram/dl [1.43 +/- 0.23 mumoles/l]; P less than 0.0005). Serum Vitamin A levels increased with duration (months) of dialysis but not with frequency of dialysis (twice or thrice weekly). Patients taking a VitaminA-containing multivitamin preparation had higher serum Vitamin A levels than those on a non-Vitamin A supplemented diet. Bilaterally nephrectomized patients had the highest serum Vitamin A levels while patients with obstructive uropathy had the lowest levels. Serum Vitamin A levels did not correlate with symptoms of uremia. Positive correlations were found with serum levels of calcium, cholesterol and triglycerides. Patients receiving a Vitamin A supplement had higher serum cholesterol levels than non-supplemented patients. Vitamin A might be a factor in the high incidence of cardiovascular disease in RDT patients. We therefore advise discontinuing the long-term administration of Vitamin A-containing multivitamin supplements to patients on RDT. PMID:527272

  17. Procalcitonin: a diagnostic and prognostic biomarker of sepsis in burned patients

    Mokline, A.; Garsallah, L.; Rahmani, I.; Jerbi, K.; Oueslati, H.; Tlaili, S.; Hammouda, R.; Gasri, B.; Messadi, A.A.

    2015-01-01

    Summary The goal of this study was to analyse plasma procalcitonin (PCT) concentrations during infectious events of burns in ICU. We conducted a prospective, observational study in a 20-bed Burn Intensive Care Unit in Tunisia. A total of 121 patients admitted to the Burn ICU were included in our study. Serum PCT was measured over the entire course of stay in patients with predictive signs of sepsis according to the Americain Burn Association Criteria for the presence of infection. Patients were assigned to two groups depending on the clinical course and outcome: Group A = non septic patients; Group B = septic patients. A PCT cutoff value of 0,69 ng/ml for sepsis prediction was associated with the optimal combination of sensitivity (89%), specificity (85%), positive predictive value (82%) and negative predictive value (88%). Serum procalcitonin levels can be used as an early indicator of septic complication in patients with severe burn injuries as well as in monitoring the response to antimicrobial therapy. PMID:27252609

  18. Delta Procalcitonin Is a Better Indicator of Infection Than Absolute Procalcitonin Values in Critically Ill Patients: A Prospective Observational Study.

    Trásy, Domonkos; Tánczos, Krisztián; Németh, Márton; Hankovszky, Péter; Lovas, András; Mikor, András; Hajdú, Edit; Osztroluczki, Angelika; Fazakas, János; Molnár, Zsolt

    2016-01-01

    Purpose. To investigate whether absolute value of procalcitonin (PCT) or the change (delta-PCT) is better indicator of infection in intensive care patients. Materials and Methods. Post hoc analysis of a prospective observational study. Patients with suspected new-onset infection were included in whom PCT, C-reactive protein (CRP), temperature, and leukocyte (WBC) values were measured on inclusion (t 0) and data were also available from the previous day (t -1). Based on clinical and microbiological data, patients were grouped post hoc into infection- (I-) and noninfection- (NI-) groups. Results. Of the 114 patients, 85 (75%) had proven infection. PCT levels were similar at t -1: I-group (median [interquartile range]): 1.04 [0.40-3.57] versus NI-group: 0.53 [0.16-1.68], p = 0.444. By t 0 PCT levels were significantly higher in the I-group: 4.62 [1.91-12.62] versus 1.12 [0.30-1.66], p = 0.018. The area under the curve to predict infection for absolute values of PCT was 0.64 [95% CI = 0.52-0.76], p = 0.022; for percentage change: 0.77 [0.66-0.87], p value for delta-PCT to indicate infection was 0.76 ng/mL (sensitivity 80 [70-88]%, specificity 86 [68-96]%). Neither absolute values nor changes in CRP, temperature, or WBC could predict infection. Conclusions. Our results suggest that delta-PCT values are superior to absolute values in indicating infection in intensive care patients. This trial is registered with ClinicalTrials.gov identifier: NCT02311816. PMID:27597981

  19. Abnormal plasma levels of serine, methionine, and taurine in transient acute polymorphic psychosis

    D. Fekkes (Durk)

    1994-01-01

    textabstractThe present study explored the usefulness of plasma amino acid concentrations in discriminating a subgroup of patients with transient acute polymorphic psychoses characterized by psychosensory symptoms (APP+ patients). Levels of amino acids in the plasma of APP+ patients were compared wi

  20. Clinical significance of serum procalcitonin and C-reaction protein in the patients with ulcerative colitis

    李楠

    2014-01-01

    Objective To approach on clinical value of serum procalcitonin(PCT)and C-reactive protein(CRP)in diagnosis of ulcerative colitis(UC).Methods The PCT and CRP levels in 120 UC patients and 20 healthy volunteers were measured.Results The levels of serum T PCT and CRP levels in active UC and catabolic UC were higher than control group[(1.56±0.36)vs(0.33±0.16)μg/L,(6.57±2.96)vs(0.33±0.16)μg/L,(6.78±3.85)vs(0.68±0.23)mg/L,(23.46±12.53)vs(0.68±0.23)

  1. Pro-calcitonin and inflammation in chronic hemodialysis

    Hernán Trimarchi

    2013-10-01

    Full Text Available Procalcitonin (PCT has emerged as a marker of infection, a frequent complication in hemodialysis (HD. We analyzed PCT levels in chronic non-acutely infected HD subjects, assessed its correlation with inflammatory and nutritional markers and propose a PCT reference value for non-infected HD patients.In an observational cross-sectional study, 48 chronic HD patients and 36 controls were analyzed. Variables: age, gender, time on HD; diabetes; vascular access, PCT, C-reactive protein (CRP, albumin, malnutrition inflammatory score (MIS, hematocrit, leukocyte count, and body mass index (BMI. Subsequently, control (G1, n = 36, 43% vs. non-infected patients (G2, n = 48, 57% groups were compared. In control subjects (G1, age: 54.3 ± 13.7 years, range (r: 30-81; males: 19 (53%; median PCT 0.034 ng/ml (r: 0.02-0.08; median CRP 0.80 mg/dl (r: 0.36-3.9; p95 PCT level: 0.063 ng/ml. In G2, age: 60.2 ± 15.2 years; males 32 (67%, time on HD: 27.0 ± 24.4; diabetics: 19 (32%; median PCT: 0.26 ng/ml (r: 0.09-0.82; CRP: 1.1 mg/dl (r: 0.5-6.2; p95 PCT level: 0.8 ng/ml. In control subjects, PCT and CRP were significantly lower than in G2: PCT: 0.034 vs. 0.26 ng/ml, p = 0.0001; CRP: 0.8 vs. 1.1 mg/dl, p = 0.0004. PCT-CRP correlation in G2: ρ = 0.287, p = 0.048. PCT and CRP concentrations are elevated in chronic non-acutely infected HD subjects, independently of infection, diabetes and vascular access. A p95 PCT level of 0.8 ng/ml may be considered as the upper normal reference value in non-acutely infected HD subjects. The PCT cut-off level in HD is yet to be determined in HD.

  2. Procalcitonin determined at emergency department as an early indicator of progression to septic shock in patient with sepsis associated with ureteral calculi

    Young Hwii Ko; Yoon Seob Ji; Sin-Youl Park; Su Jin Kim; Phil Hyun Song

    2016-01-01

    ABSTRACT Introduction: To investigate the role of initial procalcitonin (PCT) level as an early predictor of septic shock for the patient with sepsis induced by acute pyelonephritis (APN) secondary to ureteral calculi. Materials and Methods: The data from 49 consecutive patients who met criteria of sepsis due to APN following ureteral stone were collected and divided into two groups: with (n=15) or without (n=34) septic shock. The clinical variables including PCT level for this outcome were...

  3. Association of Serum Ferritin Level with Risk of Incident Abnormal Glucose Metabolism in Southwestern China: a Prospective Cohort Study.

    Zhou, Fangli; Zhao, Zhuoxian; Tian, Li; Zheng, Tianpeng; Gao, Yun; Chen, Tao; Yan, Fangfang; Tian, Haoming

    2016-01-01

    This prospective cohort study aimed to analyze the association between serum ferritin levels and the risk of abnormal glucose metabolism (AGM) in Southwestern Chinese population. The 383 subjects who are aged ≥20 years and free of AGM at baseline between in 2007 and in 2008 were included in Southwestern China, and their baseline serum ferritin levels were measured. Among these subjects, 140 subjects were developed into AGM during the follow-up (2008-2012). In logistic regression models, the relative risk in the top versus that in the lowest quartile of serum ferritin levels was 2.86 (p = 0.013) in females and 3.50 (p = 0.029) in males after adjusting the age, gender, family history of diabetes, current smoking, and alcohol; however, serum ferritin levels were not significantly associated with incident of AGM after controlling for metabolic factors (waist circumference, systolic pressure (SBP), triglyceride (TG), and homeostasis model assessment formula insulin resistance (HOMA-IR)). Elevated serum ferritin levels are associated with AGM but not an independent risk factor. PMID:26073512

  4. Procalcitonin: A Key Marker in Children with Urinary Tract Infection

    Sandrine Leroy

    2011-01-01

    Full Text Available Urinary tract infections (UTIs are the most common source of bacterial infections among young febrile children. Accurate diagnosis of acute pyelonephritis (APN and vesicoureteral reflux (VUR is important because of their association with renal scarring, leading in the cases to long-term complications. However, the gold standard examinations for both are either DMSA scan (for APN and scar or cystography (for VUR and present limitations (feasibility, pain, cost, etc.. Procalcitonin, a reliable marker of bacterial infections, was demonstrated to be a good predictor of both renal parenchymal involvement in the acute phase and late renal scars. Furthermore, it was also found to be associated with high-grade VUR and was the key tool of a clinical decision rule to predict high-grade VUR in children with a first UTI. Therefore, procalcitonin may certainly be found playing a role in the complex and still debated picture of which examination should be performed after UTI in children.

  5. Significance of procalcitonin concentration in blood plasma in septic state diagnostic

    V.V. Morrison

    2010-06-01

    Full Text Available The article highlights and generalizes data presented in native and foreign scientific literature. It is devoted to the structure, synthesis and procalcitonin secretion by different cells. The main objective of the work is the significance of procalcitonin determination in septic state diagnostics

  6. The diagnostic accuracy of procalcitonin for bacteraemia: A systematic review and meta-analysis

    S.H. Hoeboer (Sandra); P.J. van der Geest (Patrick); D. Nieboer (Daan); A.B.J. Groeneveld (A.B. Johan)

    2015-01-01

    textabstractThe diagnostic use of procalcitonin for bacterial infections remains a matter of debate. Most studies have used ambiguous outcome measures such as sepsis instead of infection. We performed a systematic review and meta-analysis to investigate the diagnostic accuracy of procalcitonin for b

  7. Comparison of serum procalcitonin in respiratory infections and bloodstream infections

    Zhu, Yanhui; Yuan, Yulin; Huang, Huayi

    2015-01-01

    Purpose: This study observed the relationship between procalcitonin (PCT) and results of sputum culture, the relationship between PCT and results of blood culture to evaluate and compare the value of PCT in respiratory and bloodstream infections. Methods: We analyzed 1616 patients in which PCT and sputum culture were concurrently ordered and analyzed, and 1096 patients in which PCT and blood culture were concurrently ordered and analyzed from January 2014 to May 2015. PCT concentrations were ...

  8. Procalcitonin Sebagai Marker dan Hubungannya dengan Derajat Keparahan Sepsis

    Purba, Donald Boy P.

    2011-01-01

    Background : The mortality on sepsis is still high. It’s because of delayed ofthe treatment resulted from the diagnosis of sepsis estabilished more frequently imprecise. The inflammatory makers as c reactive protein and leucocyte apparently have high sensitivity and specifity where do contemn whereas blood culture examination required so long time and the result of culture often negatively. Research on Procalcitonin (PCT) formering have important of the role for the establishment diagnos...

  9. Kadar Procalcitonin sebagai marker dan hubungannya dengan derajat keparahan sepsis.

    Purba, Donald Boy P.

    2012-01-01

    Background : The mortality on sepsis is still high. It’s because of delayed ofthe treatment resulted from the diagnosis of sepsis estabilished more frequently imprecise. The inflammatory makers as c reactive protein and leucocyte apparently have high sensitivity and specifity where do contemn whereas blood culture examination required so long time and the result of culture often negatively. Research on Procalcitonin (PCT) formering have important of the role for the establishment diagnos...

  10. Diagnostic accuracy of procalcitonin in critically ill immunocompromised patients

    Legriel Stéphane; Feugeas Jean-Paul; Coquet Isaline; Darmon Michael; Bele Nicolas; Adaoui Nadir; Schlemmer Benoît; Azoulay Élie

    2011-01-01

    Abstract Background Recognizing infection is crucial in immunocompromised patients with organ dysfunction. Our objective was to assess the diagnostic accuracy of procalcitonin (PCT) in critically ill immunocompromised patients. Methods This prospective, observational study included patients with suspected sepsis. Patients were classified into one of three diagnostic groups: no infection, bacterial sepsis, and nonbacterial sepsis. Results We included 119 patients with a median age of 54 years ...

  11. Procalcitonin as a marker of bacterial infection Review

    Çelebi, Gönen; Taştan, Yücel

    2002-01-01

    Because of the early diagnosis and treatment of bacterial infection markedly improves the outcome the use of nonspecific screening tests for assesment of the potentially infected patient are often employed Inflammatory markers currently in use such as leucocyte count C reactive protein and erythrocyte sedimentation rate do not reliably differentiate between bacterial and viral infection The ability to screen for bacterial infection has been evolving over time Procalcitonin is a newer marker o...

  12. Procalcitonin as a marker for the diagnosis of sepsis

    C. G. Chivate; G. J. Belwalkar; R. P. Limaye; Rahul V. Patil

    2016-01-01

    Background: Quick diagnosis of sepsis in intensive care unit patients is challenging for physicians. Methods: The prospective study was conducted at our hospital. We studied the efficacy of procalcitonin as a marker of sepsis in 87 adults admitted to our intensive care unit with symptoms of systemic infection. The study samples included all patients aged above 18 years with acute sepsis. Statistical analyses were done using SPSS. PCT and various other relevant factors were measured in all...

  13. Procalcitonin for detecting community-acquired bacterial pneumonia

    Devi Gusmaiyanto; Finny Fitry Yani; Efrida Efrida; Rizanda Machmud

    2016-01-01

    Background Pneumonia is a major cause of morbidity andmortality in children under five years of age. Pneumonia can be ofbacterial or viral origin. It is difficult to distinguish between thesetwo agents based on clinical manifestations, as well as radiologicaland laboratory examinations. Furthermore, bacterial cultures taketime to incubate and positive results may only be found in 10-30%of bacterial pneumonia cases. Procalcitonin has been used as amarker to distinguish etiologies, as bacterial...

  14. Procalcitonin kinetics – prognostic and diagnostic significance in septic patients

    Lipińska-Gediga, Małgorzata; Mierzchała-Pasierb, Magdalena; Durek, Grażyna

    2016-01-01

    Introduction Severe sepsis and septic shock are advanced clinical conditions representing the patient's response to infection and having a variable but high mortality rate. Early evaluation of sepsis stage and choice of adequate treatment are key factors for survival. Some study results suggest the necessity of daily procalcitonin (PCT) monitoring because of its prognostic and discriminative value. Material and methods An observational and prospective study was conducted to evaluate the progn...

  15. A novel marker procalcitonin may help stem the antibiotic overuse in emergency setting.

    Kaur, Kamalpreet; Mahajan, Rajiv; Tanwar, Aparna

    2013-07-01

    The day the wonder drugs, antibiotics, were available for cure to humans; dramatic rise of average life expectancy has been recorded compared to past. However, disease-causing microbes that have developed resistance to antibiotics are an increasing public health problem. Recently, superbug emergence was reported in some countries including India. One of the reasons quoted was misuse of antibiotics. Clinical signs and symptoms of infection often do not point towards the etiology. The dilemma occurs as diagnosis of sepsis is difficult because of nonspecificity of clinical signs and symptoms, and frequent overlapping of symptoms with other noninfectious causes of systemic inflammation. Key for improving survival rates lies in early diagnosis and treatment. Serum procalcitonin (PCT) levels measuring in sick patients during infection may be valuable in diagnosing the conditions, and its changing levels have some prognostic value too. PMID:24083140

  16. Procalcitonin guidance for reduction of antibiotic use in patients hospitalized with severe acute exacerbations of asthma: a randomized controlled study with 12-month follow-up

    Long, Wei; Li, Li-juan; Huang, Gao-zhong; Zhang, Xue-Min; Zhang, Yi-cui; Tang, Jian-Guo; Zhang, Yu; Lu, Gang

    2014-01-01

    Introduction Patients with severe acute exacerbations of asthma often receive inappropriate antibiotic treatment. We aimed to determine whether serum procalcitonin (PCT) levels can effectively and safely reduce antibiotic exposure in patients experiencing exacerbations of asthma. Methods In this randomized controlled trial, a total of 216 patients requiring hospitalization for severe acute exacerbations of asthma were screened for eligibility to participate and 169 completed the 12-month foll...

  17. Is procalcitonin increased in cases of invasive amoebiasis? A retrospective, observational study.

    Recipon, Guillaume; Piver, Éric; Caille, Agnès; Le Pape, Patrice; Pihet, Marc; Pagès, Jean-Christophe; Chandenier, Jacques; Desoubeaux, Guillaume

    2015-12-01

    Procalcitonin (PCT) levels are commonly used for diagnostic guidance in routine bacterial infections. By contrast, little data are currently available regarding PCT in parasitic diseases, and its role in cases of invasive amoebiasis has not yet been described. For this purpose, 35 adult patients with a proven diagnosis of invasive or digestive amoebiasis were included in a 4-year study period. Serum PCT was retrospectively assessed. Results were analysed with regard to the usual inflammatory biomarkers, like C-reactive protein (CRP). PCT was significantly higher in patients with proven invasive amoebiasis than in digestive amoebiasis (mean value: 4.03 μg/L versus 0.07 μg/L, respectively; P < 0.001), but the SD was greater than with CRP, and the effect was less than that demonstrated in bacterial infections. By contrast, PCT was not shown to be elevated during digestive amoebiasis. PMID:26388549

  18. Abnormal nociception and opiate sensitivity of STOP null mice exhibiting elevated levels of the endogenous alkaloid morphine

    Aunis Dominique

    2010-12-01

    Full Text Available Abstract Background- Mice deficient for the stable tubule only peptide (STOP display altered dopaminergic neurotransmission associated with severe behavioural defects including disorganized locomotor activity. Endogenous morphine, which is present in nervous tissues and synthesized from dopamine, may contribute to these behavioral alterations since it is thought to play a role in normal and pathological neurotransmission. Results- In this study, we showed that STOP null brain structures, including cortex, hippocampus, cerebellum and spinal cord, contain high endogenous morphine amounts. The presence of elevated levels of morphine was associated with the presence of a higher density of mu opioid receptor with a higher affinity for morphine in STOP null brains. Interestingly, STOP null mice exhibited significantly lower nociceptive thresholds to thermal and mechanical stimulations. They also had abnormal behavioural responses to the administration of exogenous morphine and naloxone. Low dose of morphine (1 mg/kg, i.p. produced a significant mechanical antinociception in STOP null mice whereas it has no effect on wild-type mice. High concentration of naloxone (1 mg/kg was pronociceptive for both mice strain, a lower concentration (0.1 mg/kg was found to increase the mean mechanical nociceptive threshold only in the case of STOP null mice. Conclusions- Together, our data show that STOP null mice displayed elevated levels of endogenous morphine, as well as an increase of morphine receptor affinity and density in brain. This was correlated with hypernociception and impaired pharmacological sensitivity to mu opioid receptor ligands.

  19. Decreased levels of genuine large free hCG alpha in men presenting with abnormal semen analysis

    Plas Eugen

    2011-08-01

    Full Text Available Abstract Background The pregnancy hormone human chorionic gonadotropin (hCG and its free subunits (hCG alpha, hCG beta are produced in the male reproductive tract and found in high concentrations in seminal fluid, in particular hCG alpha. This study aimed to elucidate changes in peptide hormone profiles in patients showing abnormal semen analyses and to determine the genuineness of the highly abundant hCG alpha. Methods Seminal plasma was obtained from 45 male patients undergoing semen analysis during infertility workups. Comprehensive peptide hormone profiles were established by a panel of immunofluorometric assays for hCG, hCG alpha, hCG beta and its metabolite hCG beta core fragment, placental lactogen, growth hormone and prolactin in seminal plasma of patients with abnormal semen analysis results (n = 29 versus normozoospermic men (n = 16. The molecular identity of large hyperglycosylated hCG alpha was analyzed by mass-spectrometry and selective deglycosylation. Results hCG alpha levels were found to be significantly lower in men with impaired semen quality (1346 +/- 191 vs. 2753 +/- 533 ng/ml, P = 0.022. Moreover, patients with reduced sperm count had reduced intact hCG levels compared with normozoospermic men (0.097 +/- 0.022 vs. 0.203 +/- 0.040 ng/ml, P = 0.028. Using mass-spectrometry, the biochemical identity of hCG alpha purified from seminal plasma was verified. Under non-reducing conditions in SDS-PAGE, hCG alpha isolated from seminal plasma migrated in a manner comparable with large free hCG alpha with an apparent molecular mass (Mr, app of 24 kDa, while hCG alpha dissociated from pregnancy-derived holo-hCG migrated at approximately 22 kDa. After deglycosylation with PNGase F under denaturing conditions, all hCG alpha variants showed an Mr, app of 15 kDa, indicating identical amino acid backbones. Conclusions The findings indicate a pathophysiological relevance of hCG, particularly its free alpha subunit, in spermatogenesis. The

  20. Do abnormal serum lipid levels increase the risk of chronic low back pain? The Nord-Trondelag Health Study.

    Ingrid Heuch

    Full Text Available Cross-sectional studies suggest associations between abnormal lipid levels and prevalence of low back pain (LBP, but it is not known if there is any causal relationship.The objective was to determine, in a population-based prospective cohort study, whether there is any relation between levels of total cholesterol, high density lipoprotein (HDL cholesterol and triglycerides and the probability of experiencing subsequent chronic (LBP, both among individuals with and without LBP at baseline.Information was collected in the community-based HUNT 2 (1995-1997 and HUNT 3 (2006-2008 surveys of an entire Norwegian county. Participants were 10,151 women and 8731 men aged 30-69 years, not affected by chronic LBP at baseline, and 3902 women and 2666 men with LBP at baseline. Eleven years later the participants indicated whether they currently suffered from chronic LBP.Among women without LBP at baseline, HDL cholesterol levels were inversely associated and triglyceride levels positively associated with the risk of chronic LBP at end of follow-up in analyses adjusted for age only. Adjustment for the baseline factors education, work status, physical activity, smoking, blood pressure and in particular BMI largely removed these associations (RR: 0.96, 95% CI: 0.85-1.07 per mmol/l of HDL cholesterol; RR: 1.16, 95% CI: 0.94-1.42 per unit of lg(triglycerides. Total cholesterol levels showed no associations. In women with LBP at baseline and men without LBP at baseline weaker relationships were observed. In men with LBP at baseline, an inverse association with HDL cholesterol remained after complete adjustment (RR: 0.83, 95% CI: 0.72-0.95 per mmol/l.Crude associations between lipid levels and risk of subsequent LBP in individuals without current LBP are mainly caused by confounding with body mass. However, an association with low HDL levels may still remain in men who are already affected and possibly experience a higher pain intensity.

  1. Role of Maternal Serum Procalcitonin, Interleukin-6 and hs-C Reactive Protein in Prediciton of Subclinical (Intrauterine Infection in Preterm Premature Rupture of Membranes

    Amany M.E. Abd Elmegeed*, Sabah I. Abd Elreheem*, Al-Shimaa Allam Abd

    2011-04-01

    Full Text Available To evaluate the role of procalcitonin (PCT, high senstive C-reactive protein (hs-CRP and Interleukin-6 (IL-6 for prediction of subclinical intrauterine infection in pregnant women with preterm premature rupture of membranes. Methods: Twenty patients with preterm premature rupture of membranes PPROM (study group and twenty apparently healthy pregnant women (control group between 26-34 weeks of pregnancy were enrolled in this study. In all cases analysis of serum procalcitonin by high performance liquid chromatography, Il-6 by ELISA method and hs-CRP by nephelometry were done. Culture of vaginal bacteria was done for study group only. Results: Procalcitonin levels in the PRROM group were significantly higher than in healthy pregnant women (median 1.95 versus 0.39-Interquartile range 1.375 versus 0.213 ­ P0.001. A significant correlation was observed between PCT and hs-CRP (r=0.510; P0.031 and leucocytosis (r=0.544- P 0.013. Also IL-6 levels were significantly higher in cases of PPROM compared with control group (median 40.01 versus 5.55 ­ Interquartile range, 45.88 versus 4.22 P 0.001. No significant correlation was present between PCT and IL-6 Conclusion: Determination of PCT, hs-CRP and IL-6 in mother's blood sample can be useful for diagnostics of PPROM cases suspected of intrauterine infection. However PCT more valuable and specific.

  2. The relationship between serum procalcitonin (PCT) level and acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ ) score in septic patients%脓毒症患者降钙素原与APACHEⅡ评分的相关性探讨

    刘慧琳; 刘桂花

    2012-01-01

    Objective To investigate the relationships between serum procalcitonin (PCT) level and APACHE Ⅱ score as well the prognosis of septic patients.Methods Ninety patients with sepsis were collected from emergency and critical care department of Third Hospital,Peking University,Beijing.Within 24 hours after admission,the serum PCT,hypersensitive C-reactive protein (hs-CRP),leucocyte count (WBC) and lactic acid were examined,and APACHE Ⅱ score were calculated.According to APACHE Ⅱscore,the septic patients were divided into three groups of high,median and low scores.Based on the 28 -day outcomes of patients,the patients were divided into survival group and death group.The differences in PCT,APACHE score,WBC and lactic acid between the survival group and the death group were detected.Results The serum levels of PCT were significantly higher ( P < 0.01 ) in patients with high APACHE Ⅱ score ( > 20) than that in patients with median score (10-20) and low score ( < 10 ).There was significant correlation between PCT level and APACHE Ⅱscore ( r =0.58,P <0.01 ).Conclusions There is a good correlation between serum PCT level and APACHE Ⅱ score.The serum PCT and APACHE Ⅱ can be used for predicting the outcomes of septic patients.%目的 探讨脓毒症患者血清降钙素原(PCT)与急性生理学与慢性健康状况Ⅱ(APACHEⅡ)评分及预后的关系,进而了解PCT对脓毒症早期诊断和预后的影响.方法 采用前瞻性方法进行研究,将北京大学第三医院急诊重症监护病房(EICU)脓毒症90例患者按照APACHEⅡ评分分组,测定患者入院后24h内PCT、超敏C反应蛋白(hs-CRP)及乳酸的水平,比较PCT、白细胞和乳酸的差异.后再根据患者28 d结局不同(分为生存组和死亡组两组),比较PCT、APACHEⅡ评分、白细胞及乳酸的差异.结果 低危组患者PCT为(0.15±0.14) ng/ml,低于中危组(0.62±0.61) ng/ml和高危组(5.32±5.20) ng/ml,中危组PCT低于高危组,其差

  3. 肝衰竭患者血清降钙素原测定的应用价值%Study of procalcitonin in patients with hepatic failure

    张国栋

    2015-01-01

    Objective To explore the value of serum procalcitonin in patients with hepatic failure.Methods Totally 106 patients with hepatic failure from January 2009 to October 2014 were enrolled and divided into infection group (75 cases) and non-infection group (31 cases).After anti-infection treatment,75 cases in infection group weredivided into high procalcitonin group (33 cases) and low procalcitonin (42 cases) according to the level of serum procalcitonin.Twenty three cases of liver failure patients with calcitonin peptide < 0.5 μg/L underwent serum procalcitonin reexamination within 48 h and divided into procalcitonin increasing > 1 time group (10 cases) and procalcitonin increasing < 1 time group (13 cases).The value of procalcitonin for early diagnosis and prognosis prediction of bacterial infections were evaluated.Results In infection group,there were 72 cases with procalcitonin≥0.5 μg/L [96.0% (72/75)],significantly more than that in non-infection group [35.5% (11/31)] (x2 =47.28,P < 0.01).In high procalcitonin group,21 cases were dead [63.6% (21/33)],significantly more than that in low procalcitonin group[14.3% (6/42)] (x2 =19.53,P < 0.01).There were 6 cases in procalcitonin increasing > 1 time group and 2 cases in procalcitonin increasing < 1 time group were complicated with infection with significantly differece (P < 0.05).Conclusion Serum procalcitonin is important for early diagnosis and prediction of infection in hepatic failure patients;it is also important for prediction of hepatic failure complicated with infection.%目的 探讨血清降钙素原测定在肝衰竭患者中的应用价值.方法 回顾性分析2009年1月至2014年10月在平煤神马医疗集团总医院住院治疗的由病毒性肝炎导致的肝衰竭患者106例,测定细菌感染情况.依据是否发生感染把106例患者分为感染组(75例)和非感染组(31例).将合并细菌感染的75例肝衰竭患者按抗感染治疗后降钙素原的变

  4. Evaluation of diagnostic value of procalcitonin in pediatric acute pyelonephritis

    Simin Sadeghi-bojd

    2012-05-01

    Full Text Available Background and Aim: Urinary tract infection (UTI in children is among the prevalent infections of childhood, which occurs due to growth of bacteria in the urinary tract. The aim of this study was to evaluate the usefulness of procalcitonin (PCT as a reliable marker for distinguishing urinary tract infection (UTI with or without renal parenchyma (cystitis. Materials and Methods: Eighty children, who were suspicious of having UTI and had been referred to Ali Ibne Abitaleb hospital (in Zahedan or pediatric clinics (June 2007- Oct 2009 were included in the study after their urine culture revealed their infection. Besides, their clinical and lab symptoms including erythrocyte sedimentation rate (ESR, C– reactive protein (CRP, serum WBC, and serum procalcitonin (PCT were recorded. The patients were divided into two groups based on their lab clinical symptoms and radio-isotope scans, namely acute pyelonephritis and acute cystitis (lower UTI. Serum procalcitonin was measured in these cases in a semi-quantitative manner. Results: Fifty children with mean age of 4.89±3.50 years were compared with 30 children with mean age of 5.20±3.07 years. ESR, WBC, and PCT were significantly higher in patients with upper UTI (P<0.001 , but CRP was not significantly different in the two groups. PCT, which was semi-quantitatively measured, when lower than 0.5 had a relationship with sensitivity, specificity, positive predictive value, and negative value of 72%, 83.3%, 87.8%, and 64.1% respectively. When PCT was more than 2, the relationship with the mentioned features was 50%, 96.6%, 96.2%, and 53.7%, respectively. The relationships in these two domains can both be assistant in differentiating pyelonephritis from cystitis. Conclusion: PCT was more sensitive and specific for the diagnosis of upper versus lower UTI compared with CRP, and it can be a better marker than CRP for early prediction of febrile pyelonephritis in children.

  5. The methodological evaluation of detecting procalcitonin by immunoturbidimetric assay%免疫透射比浊法检测降钙素原的实验评价

    金强; 姚晓玲; 胡恩赑

    2012-01-01

    Objective To evaluate the method of procalcitonin detection by immunoturbidmetric assay. Methods Immunoturbidmetric assay was established to determine serum procalcitonin, and then its precision, linearity, recovery and interference test were evaluated. Results The method had a good linearity response ( y = 1. 152x -0.0452 ), and the linear correlation coefficient r =0. 999. The inter and intra CVs of the serum procalcitonin levels were lower than 5% and 10% , respectively. The average recovery was 97. 7% . Some degree of bilirubin, hemoglobin and triglycerides did not interfere with the procalcitonin results significantly. Conclusion Immunoturbidmetric assay is a simple, fast and automated detection method, which shows good performance in clinical use.%目的 对免疫透射比浊法定量测定降钙素原的方法进行实验评价.方法 实验评价包括精密度、线性、回收实验及干扰实验.结果 该方法测定降钙素原线性良好(y=1.152x-0.0452,r=0.999),批内CV<5%,批间CV<10%;回收率平均97.7%;对胆红素、血红蛋白及三酰甘油具有较好的干扰能力.结论 该方法简便、快速,便于自动化检测,适合临床使用.

  6. Serum Procalcitonin and Procalcitonin Clearance as a Prognostic Biomarker in Patients with Severe Sepsis and Septic Shock

    Min-Yi Huang; Chun-Yu Chen; Ju-Huei Chien; Kun-Hsi Wu; Yu-Jun Chang; Kang-Hsi Wu; Han-Ping Wu

    2016-01-01

    We evaluated the tendency of the plasma concentration and procalcitonin (PCT) clearance (PCTc) to act as biomarkers of prognosis in patients with severe sepsis and septic shock. From 2011 to 2013, we prospectively analyzed patients with sepsis admitted to the intensive care unit (ICU). The serum PCT was evaluated at the time of sepsis diagnosis and again after 48 h (day 3) and 96 h (day 5). PCTc after 48 h (PCTc-day 3) and 96 h (PCTc-day 5) was also calculated to evaluate the prognostic value...

  7. The Prognosis Value of Change Levels of Serum Procalcitonin in Early Stage on Patients with Severe Trauma%严重创伤患者早期血清降钙素原水平变化对预后评估的意义

    杨兴伟; 董士民

    2013-01-01

    Objective To explore levels of serum procalcitonin (PCT) in patients with severe trauma in evaluation of clinical significances of prognosis.Methods Levels of serum PCT in 93 patients with systemic inflammatory response syndrome (SIRS)after severe trauma were detected at 1 st d,2nd d and 3rd d before admission,and the division of groups was based on changes of the levels of serum PCT.Survival rates,times of mechanical ventilation,length of stay in ICU,and the correlation between PCT levels and scores of severe trauma levels at 28th d after admission were evaluated.Results Among 93 patients,83 patients survived (survival group) and 10 patients died (mortality group) at 28th d after admission.Levels of serum PCT at the 3 d before admission in mortality group were significantly higher than those in survival group (P < 0.05),and the trend rose higher and higher (P < 0.05) ;the differences in length of stay in ICU and times of mechanical ventilation between mortality group and survival group were statistically significant (P < 0.05).All the patients in normal group (n =10) and low level group (n =26) survived,1 patient (2.17%)died in middle level group (n =46),9 patients (81.82%) died in high level group (n =11),the mortality rate in high level group was significantly higher than those in other groups (P < 0.05).With PCT levels increased,times of mechanical ventilation,length of stay in ICU,and scores of severe trauma levels were significantly increased (P < 0.05).Spearman correlative analysis shows that PCT level was correlated with APACHE Ⅱ and ISS scores (P < 0.05).Conclusion As a marker to evaluate the prognosis the level of serum PCT is connected with prognosis of patients with severe trauma.%目的 探讨严重创伤患者中血清降钙素原(PCT)对患者预后评估的临床意义.方法 收集93例入院时存在全身炎症反应综合征的严重创伤,入院前3d每天检测血清PCT水平,并根据PCT水平

  8. Procalcitonin-guided antibiotic treatment of respiratory tract infections in a primary care setting

    Aabenhus, Rune; Jensen, Jens Ulrik Stæhr

    2011-01-01

    , could greatly improve patient care and limit excessive antibiotic prescriptions. Procalcitonin is a new marker of suspected bacterial infection that has shown promise in guiding antibiotic therapy in acute respiratory tract infections in hospitals without compromising patient safety. Procalcitonin......-of-care test for procalcitonin with acceptable precision, severely hampering its application in primary care. This article reviews the physiology of procalcitonin, describes the assays available for its measurement, evaluates the present evidence from primary care on its use to identify correctly patients who......Clinical signs of infection do not allow for correct identification of bacterial and viral aetiology in acute respiratory infections. A valid tool to assist the clinician in identifying patients who will benefit from antibiotic therapy, as well as patients with a potentially serious infection...

  9. Procalcitonin and community-acquired pneumonia (CAP) in children.

    Giulia, Bivona; Luisa, Agnello; Concetta, Scazzone; Bruna, Lo Sasso; Chiara, Bellia; Marcello, Ciaccio

    2015-12-01

    The role of procalcitonin (PCT) as a biomarker for sepsis in adults is well documented, while its role in infections affecting neonatal children remains controversial. Among these infections, Community-Acquired pneumonia (CAP) has been studied extensively, because it's the second cause of death in children in developing countries, and one of the most frequent causes of hospitalization in industrialized countries. The PubMed database and the Cochrane Library were used to search for the following keywords: CAP, procalcitonin, and children. Thirteen articles were studied to determine the role of PCT in CAP management, specifically its usefulness for distinguishing pneumococcal infections from viral and unknown infections, for predicting severity and the correct antibiotic treatment. This paper focuses on the studies performed to identify the best inflammatory biomarker for CAP management. Although there is an increase in studies confirming the usefulness of PCT in CAP management in children, further studies are needed to have better understanding of its role for pediatric CAP management. PMID:26434548

  10. Prognostic and diagnostic value of procalcitonin in the post-transplant setting after liver transplantation

    Perrakis, Aristotelis; Stirkat, Falk; Croner, Roland S; Vassos, Nikolaos; Raptis, Dimitrios; Yedibela, Süleyman; Hohenberger, Werner; Müller, Volker

    2016-01-01

    Introduction The aim of the study was to assess the diagnostic accuracy of procalcitonin (PCT) as a marker for complications and as a prognostic factor for mortality after liver transplantation. Material and methods Liver transplant patients between January 2007 and April 2011 were prospectively included in the study. Procalcitonin serum concentration was recorded before, 6 h after reperfusion and then daily. Postoperative clinical course was prospectively analyzed from admission to discharge...

  11. The Early Diagnostic Value of Serum Procalcitonin in Eldely Patients with Severe Pneumonia%降钙素原对老年性重症肺炎早期诊断的价值

    高萌萌; 崔丽

    2014-01-01

    目的评价血清降钙素原(procalcitonin,PCT)对老年性重症肺炎早期诊断的价值及临床意义。方法入院24 h内抽取30例老年性重症肺炎患者及30例轻症老年肺炎患者血液,检测PCT、C反应蛋白、白细胞计数、血沉,并对比。结果 PCT与其他指标相比,具有较高的灵敏性及特异性。结论 PCT对肺炎的诊断有一定的价值,对老年性重症肺炎早期诊断及病情评估价值更大,与肺炎的严重程度具有相关性。%Objective To investigate the early diagnostic value and clinical significanca of serum procalcitonin in eldely patients with severe pneumonia. Methods Drawed blood from 30 eldely patients with severe pneumonia and mild pneumonia respectively within 24h admission,simultaneously determined and compared procalcitonin,c-reactive protein levels,white blood cellcount,erythrocyte-sedimentation rate. Results Compared with other index, the procalcitonin has high sensitivity and specificity. Conclusion The procalcitonin has diagnosis value to roentgenodiagnosis of pneumonia.It has great value in diagnosis early and estimation prognosis diagnosis,and has positive correlation with the disease severity.

  12. Serum procalcitonin: Early detection of neonatal bacteremia and septicemia in a tertiary healthcare facility

    Ibeh Isaiah Nnanna

    2011-01-01

    Full Text Available Background: The benefits of procalcitonin measurement in neonatal bacteremia/septicemia with suspected nosocomial infection are unclear and unresearched. Aim: The aim of the study was to assess procalcitonin value as an early or first line diagnosis/prognosis for bacterial neonatal septicemic infection in selected critically ill neonates. Patients and Methods: An observational cohort study in a 10-bed intensive care unit was performed. Sixty neonates, with either proven or clinically suspected, but not confirmed, bacterial neonatal septicemic infection were included. Procalcitonin measurements were obtained on the day when the infection was suspected. Neonates with proven septicemic infection were compared to those without. The diagnostic value of procalcitonin was determined through the area under the corresponding receiver operating characteristic curve (AUROCC. In addition, the predictive value of procalcitonin variations preceding the clinical suspicion of infection was also assessed. Results: Procalcitonin was the best early predictor of proven infection in this population of neonates with a clinical suspicion of septicemia (AUROCC = 0.80; 91.6% CI, 0.68-0.91. In contrast, CRP elevation, leukocyte count and fever had a poor predictive value in our population. Conclusion: PCT monitoring could be helpful in the early diagnosis of neonatal septicemic infection in the intensive care unit. Both absolute values and variations should be considered and evaluated in further studies.

  13. Serum procalcitonin: Early detection of neonatal bacteremia and septicemia in a tertiary healthcare facility

    Ibeh Isaiah Nnanna

    2011-03-01

    Full Text Available Background: The benefits of procalcitonin measurement in neonatal bacteremia/septicemia with suspected nosocomial infection are unclear and unresearched. Aim: The aim of the study was to assess procalcitonin value as an early or first line diagnosis/prognosis for bacterial neonatal septicemic infection in selected critically ill neonates. Patients and Methods: An observational cohort study in a 10-bed intensive care unit was performed. Sixty neonates, with either proven or clinically suspected, but not confirmed, bacterial neonatal septicemic infection were included. Procalcitonin measurements were obtained on the day when the infection was suspected. Neonates with proven septicemic infection were compared to those without. The diagnostic value of procalcitonin was determined through the area under the corresponding receiver operating characteristic curve (AUROCC. In addition, the predictive value of procalcitonin variations preceding the clinical suspicion of infection was also assessed. Results: Procalcitonin was the best early predictor of proven infection in this population of neonates with a clinical suspicion of septicemia (AUROCC = 0.80; 91.6% CI, 0.68–0.91. In contrast, CRP elevation, leukocyte count and fever had a poor predictive value in our population. Conclusion: PCT monitoring could be helpful in the early diagnosis of neonatal septicemic infection in the intensive care unit. Both absolute values and variations should be considered and evaluated in further studies.

  14. Can procalcitonin measurement help in differentiating between bacterial infection and other kinds of inflammatory processes?

    Delevaux, I; Andre, M; Colombier, M; Albuisson, E; Meylheuc, F; Begue, R; Piette, J; Aumaitre, O

    2003-01-01

    Objective: To study the levels of procalcitonin (PCT) in various inflammatory states seen in an internal medicine department and to evaluate the possible discriminative role of PCT in differentiating bacterial infection from other inflammatory processes. Methods: PCT, C reactive protein (CRP), and white blood cell count (WBC) were measured in patients admitted to the department for fever or biological inflammatory syndrome, or both. The serum of 173 consecutive patients was analysed according to the aetiological diagnosis. The patients were divided into two groups: group I (n=60) with documented bacterial or fungal infection; group II (n=113) with abacterial inflammatory disease. Results: PCT levels were >0.5 ng/ml in 39/60 (65%) patients in group I. In group II, three patients with a viral infection had slightly increased PCT levels (0.7, 0.8, and 1.1 ng/ml) as did two others, one with crystal arthritis and the other with vasculitis (0.7 ng/ml in both cases). All other patients in group II had PCT levels 0.5 ng/ml was taken as the marker of bacterial infection (sensitivity 65%, specificity 96%). PCT values were more discriminative than WBC and CRP in distinguishing a bacterial infection from another inflammatory process. Conclusion: PCT levels only rose significantly during bacterial infections. In this study PCT levels >1.2 ng/ml were always evidence of bacterial infection and the cue for starting antibiotic treatment. PMID:12634233

  15. Value of serum procalcitonin in anti-tuberculosis therapeutic effect evaluation for tuberculosis%血清降钙素原在肺结核抗结核治疗疗效评估中的价值

    徐立; 金雪

    2013-01-01

    目的研究血清降钙素原在肺结核抗结核治疗疗效评估中的价值。方法选择2012年1月~2013年1月本科诊治的肺结核患者为研究对象(观察组),以同期未行抗结核治疗的肺结核患者为对照(对照组),比较两组患者治疗前后血清降钙素原的水平并分析不同水平降钙素原抗结核治疗疗效差异。结果观察组和对照组肺结核患者治疗前血清降钙素原差异无统计学意义,观察组患者治疗后1个月、3个月和6个月血清降钙素原显著降低( P<0.05),对照组治疗1个月、3个月和6个月血清降钙素原升高,观察组肺结核患者治疗1个月、3个月和6个月血清降钙素原均显著低于对照组(P<0.05)。治疗前降钙素原水平显著升高、轻度升高和正常患者治愈率依次降低(P<0.05)。结论肺结核患者血清降钙素原可作为其抗结核治疗疗效评估的标志物。%Objective To study the value of serum procalcitonin in anti-tuberculosis therapeutic effect evaluation for tuberculosis. Methods The patients with tuberculosis treated with anti-tuberculosis therapy in our department from January 2012 to January 2013 were selected as the observation group, while no anti-tuberculosis treatment patients with tuberculosis during the same period were selected as the control group. The level of serum procalcitonin in the two groups before and after the treatment were compared and the anti-tuberculosis therapeutic effect difference of different levels of procalcitonin were analyzed. Results There was not significant difference in the level of serum procalcitonin before the treatment between the observation group and the control group. The levels of serum procalcitonin in the observation group after the treatment of 1 month, 3 months and 6 months decreased significantly(P<0.05), while the levels of serum procalcitonin in the control group after the treatment of 1 month, 3 months and 6 months

  16. Variation in the levels of pregnancy-specific beta-1-glycoprotein in maternal serum from chromosomally abnormal pregnancies.

    Graham, G W; Crossley, J A; Aitken, D A; Connor, J M

    1992-06-01

    Human pregnancy-specific beta-1-glycoprotein (SP1) was assayed retrospectively in stored maternal serum (MS) samples from 82 chromosomally abnormal pregnancies and 377 matched controls. The median MSSP1 concentration in 48 Down's syndrome pregnancies was significantly elevated at 1.17 multiples of the control median (MOM), and significantly reduced (0.5 MOM) in a group of eight cases of unbalanced translocations. There was no significant difference in median SP1 concentrations in cases of trisomy 18, trisomy 13, balanced translocations, or sex chromosome abnormalities. A comparison with human chorionic gonadotrophin results in the same series of samples indicates that SP1 is a less sensitive predictor of Down's syndrome pregnancies. PMID:1387478

  17. The relationship between the procalcitonin level and liver function in pa-tients with hepatitis and liver cirrhosis%肝炎及肝硬化患者降钙素原水平与肝功能的关系探讨

    黄仲国

    2014-01-01

    Objective To explore the relationship between the serum procalcitonin(PCT) level and liver function in pa-tients with hepatitis and liver cirrhosis. Methods A retrospective analysis of 80 cases of hepatitis B virus in our hospi-tal from December 2012 to December 2013 admitted (hepatitis B virus, HBV) infection in patients with hepatitis and liver cirrhosis, included acute hepatitis B (acute hepatitis B, AHB) infection in 20 patients and hepatic cirrhosis (hep-atic cirrhosis, HC) infection in 60 patients. PCT in peripheral blood, white blood cell count, neutrophil count and liver function tests (ALT, AST, TBIL, PTA) levels before and after treatments in patients, and the relationship between PCT and liver function of patients were evaluated. Results PCT level, white blood cell count and neutrophil count in AHB patients and HC patients before treatment were significantly higher than that after treatment, there was statistically sig-nificant difference (t=11.411, 2.217, 3.567, P<0.05); After treatment, patients liver function was significantly improved than before treatment, the difference was statistically significant (t=14.465, 13.164, 14.563, 8.579, P<0.05);The level of PCT in serum and liver function of ALT, AST, TBIL were positively correlated, negatively correlated with the level of PTA (r=0.877, 0.964, 0.859, -0.744, P<0.05). Conclusion There is correlation between PCT level and each index in patients with hepatitis B virus infection and liver cirrhosis, which have significance in treatment patients with infection and liver function disorder.%目的:分析探讨肝炎及肝硬化患者血清中降钙素原(procalcitonin,PCT)水平与其肝功能的关系。方法回顾性分析我院2012年12月~2013年12月收治的80例乙型肝炎病毒(hepatitis B virus,HBV)感染的肝炎及肝硬化患者,其中急性乙型肝炎(acute hepatitis B,AHB)患者20例,肝硬化(hepatic cirrhosis,HC)患者60例,分别在治疗前后检测患者

  18. Elevated postoperative serum procalcitonin is not indicative of bacterial infection in cardiac surgical patients

    Murali Chakravarthy

    2015-01-01

    Full Text Available Background: Identifying infections early, commencing appropriate empiric antibiotic not only helps gain control early, but also reduces mortality and morbidity. Conventional cultures take about 5 days to identify infections. To identify the infections early biomarker like serum procalcitonin (SPC. Aims: We studied the correlation of an elevated level of SPC and positive culture in elective adult patients undergoing cardiac surgery. Methods: This prospective study was conducted from January to December 2013. SPC was checked in patients showing evidence of sepsis. Simultaneously, relevant culture was also undertaken. Correlation, specificity, and sensitivity of elevated SPC were checked. Results: A total of 819 adult patients were included in the study. 43 of them had signs of infection and SPC levels were checked. Based on the level of SPC criteria, 10 patients were diagnosed as "nil", out of them, 4 had culture-positive infections, 17 were suggested to have "mild infection," 3 out those had culture positivity. None among the eleven patients suggested to have "moderate infection," had a positive culture, and one among the five suggested to have a severe infection had a positive culture. The sensitivity was 50% and the specificity 17%. The positive predictive value was 12% and the negative predictive value 60%. Conclusions: We failed to elicit positive correlation between elevated SPC levels and postoperative infection in cardio surgical patients.

  19. Efficiency of Fetuin-A and Procalcitonin in the Diagnosis of Infection in Patients with Febrile Seizure

    Al-Hakeim Hussein Kadhem

    2016-03-01

    Full Text Available Fetuin-A is a negative acute phase reactant, while procalcitonin is an indicator of severe bacterial infection. Diagnosis of bacterial infection in febrile seizure (FS is important for choosing the most suitable treatment. In this study, serum fetuin-A was estimated, for the first time, in the inpatients with FS and compared with procalcitonin and blood culture tests.

  20. Efficiency of Fetuin-A and Procalcitonin in the Diagnosis of Infection in Patients with Febrile Seizure

    Al-Hakeim Hussein Kadhem; Al-Ankoshy Azhar Mohammed; Alsharifi Mohammed-R.

    2016-01-01

    Fetuin-A is a negative acute phase reactant, while procalcitonin is an indicator of severe bacterial infection. Diagnosis of bacterial infection in febrile seizure (FS) is important for choosing the most suitable treatment. In this study, serum fetuin-A was estimated, for the first time, in the inpatients with FS and compared with procalcitonin and blood culture tests.

  1. Age-specific percentile-based reference curve of serum procalcitonin concentrations in Japanese preterm infants.

    Fukuzumi, Noriko; Osawa, Kayo; Sato, Itsuko; Iwatani, Sota; Ishino, Ruri; Hayashi, Nobuhide; Iijima, Kazumoto; Saegusa, Jun; Morioka, Ichiro

    2016-01-01

    Procalcitonin (PCT) levels are elevated early after birth in newborn infants; however, the physiological features and reference of serum PCT concentrations have not been fully studied in preterm infants. The aims of the current study were to establish an age-specific percentile-based reference curve of serum PCT concentrations in preterm infants and determine the features. The PCT concentration peaked in infants at 1 day old and decreased thereafter. At 1 day old, serum PCT concentrations in preterm infants <34 weeks' gestational age were higher than those in late preterm infants between 34 and 36 weeks' gestational age or term infants ≥37 weeks' gestational age. Although the 50-percentile value in late preterm and term infants reached the adult normal level (0.1 ng/mL) at 5 days old, it did not in preterm infants. It took 9 weeks for preterm infants to reach it. Serum PCT concentrations at onset in late-onset infected preterm infants were over the 95-percentile value. We showed that the physiological feature in preterm infants was significantly different from that in late preterm infants, even in those <37 weeks' gestational age. To detect late-onset bacterial infection and sepsis, an age-specific percentile-based reference curve may be useful in preterm infants. PMID:27033746

  2. Abnormal auditory mismatch response in tinnitus sufferers with high-frequency hearing loss is associated with subjective distress level

    Berg Patrick

    2004-03-01

    Full Text Available Abstract Background Tinnitus is an auditory sensation frequently following hearing loss. After cochlear injury, deafferented neurons become sensitive to neighbouring intact edge-frequencies, guiding an enhanced central representation of these frequencies. As psychoacoustical data 123 indicate enhanced frequency discrimination ability for edge-frequencies that may be related to a reorganization within the auditory cortex, the aim of the present study was twofold: 1 to search for abnormal auditory mismatch responses in tinnitus sufferers and 2 relate these to subjective indicators of tinnitus. Results Using EEG-mismatch negativity, we demonstrate abnormalities (N = 15 in tinnitus sufferers that are specific to frequencies located at the audiometrically normal lesion-edge as compared to normal hearing controls (N = 15. Groups also differed with respect to the cortical locations of mismatch responsiveness. Sources in the 90–135 ms latency window were generated in more anterior brain regions in the tinnitus group. Both measures of abnormality correlated with emotional-cognitive distress related to tinnitus (r ~ .76. While these two physiological variables were uncorrelated in the control group, they were correlated in the tinnitus group (r = .72. Concerning relationships with parameters of hearing loss (depth and slope, slope turned out to be an important variable. Generally, the steeper the hearing loss is the less distress related to tinnitus was reported. The associations between slope and the relevant neurophysiological variables are in agreement with this finding. Conclusions The present study is the first to show near-to-complete separation of tinnitus sufferers from a normal hearing control group based on neurophysiological variables. The finding of lesion-edge specific effects and associations with slope of hearing loss corroborates the assumption that hearing loss is the basis for tinnitus development. It is likely that some central

  3. Microvascular abnormalities in capillaroscopy correlate with higher serum IL-18 and sE-selectin levels in patients with type 1 diabetes complicated by microangiopathy

    Maria Górska

    2011-04-01

    Full Text Available Microvascular abnormalities are one of the most important causes of persistent diabetic complications. The aim of this study was to compare microvascular changes examined by nailfold capillaroscopy with serum concentrations of soluble E-selectin (sE-selectin and IL-18 in type 1 diabetic patients with and without microangiopathy. Serum levels of sE-selectin and IL-18 were determined by an enzyme-linked immunosorbent assay in 106 patients with type 1 diabetes and in 40 healthy controls. All diabetic patients were evaluated by extensive clinical, laboratory and capillaroscopic studies. Morphological changes were observed by nailfold capillaroscopy in 86 out of 106 (81% diabetic patients. Severe capillaroscopic changes were seen in 32 out of 54 (59% patients with microangiopathy, but in only seven out of 52 (13% patients without microangiopathy. Higher serum levels of sE-selectin (p < 0.001 and IL-18 (p < 0.05 were demonstrated in diabetic patients compared to controls. Significant differences of sE-selectin (p < 0.001 and IL-18 (p < 0.01 serum concentrations were observed between diabetic patients with microangiopathy and controls. Moreover, comparison between patients with and without microangiopathic complications showed a significantly higher capillaroscopic score and sE-selectin serum concentration in the group with microangiopathy (p < 0.001. Furthermore, diabetic patients with severe microvascular changes in capillaroscopy showed significantly higher IL-18 (p < 0.001 and sE-selectin (p < 0.05 serum levels than subgroups without changes or with mild abnormalities. Our findings suggest that abnormalities in nailfold capillaroscopy may reflect the extent of microvascular involvement and are associated with higher sE-selectin and IL-18 serum levels, as well as with microangiopathic complications in diabetic patients. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 1, pp. 104–110

  4. Congenital Abnormalities

    ... blood flow to the fetus impair fetal growth. Alcohol consumption and certain drugs during pregnancy significantly increase the risk that a baby will be born with abnormalities (e.g. fetal alcohol spectrum disorders ). Eating raw or uncooked foods during pregnancy can also be dangerous to health of the ...

  5. Procalcitonin as diagnostic marker of infection in solid tumors patients with fever.

    Vincenzi, B; Fioroni, I; Pantano, F; Angeletti, S; Dicuonzo, G; Zoccoli, A; Santini, D; Tonini, G

    2016-01-01

    In oncologic patients fever is a non-specific clinical marker of different clinical settings. Procalcitonin (PCT) seems to be the most promising infection marker. We aimed to define the potential role of PCT as an earlier diagnostic marker in patients with fever and solid tumor. This retrospective study enrolled 431 patients. All of them performed hemoculture (HE) and basal PCT assessment (reference laboratory cut-off: ≤0.5 or >0.5 ng/dL) before starting antibiotic therapy. Gram positive (G+), negative (G-) or Fungi infection were detected. A statistically significant difference in PCT levels between patients with positive and negative HE was observed (P PCT values in patients with positive and negative HE, we obtain in the positive HE subpopulation an AUC of 0.7 and a cut-off of 1.52 ng/dL reached high sensitivity (61.6%) and specificity (70.1%). Using this last cut-off, instead of the normal reference value, we achieve a risk reduction to overestimate an infection status of 23.4%. We support the clinic usefulness of serum PCT dosage in febrile advanced solid tumor patients. A PCT cut-off of 1.52 ng/dL could be helpful in the management of the antibiotic therapy preventing delays of oncologic treatments. PMID:27312877

  6. Pleural fluid procalcitonin to distinguish infectious from noninfectious etiologies of pleural effusions.

    Khosla, Rahul; Khosla, Shikha G; Becker, Kenneth L; Nylen, Eric S

    2016-05-01

    In this study we investigate the diagnostic value of pleural fluid procalcitonin (PCT) in distinguishing infectious and noninfectious etiologies of pleural effusion. We reviewed the medical records of 75 hospitalized patients who underwent thoracentesis between 2011 and 2012. Data on pleural fluid lactate dehydrogenase (LDH), protein, albumin, cell count and differential, pH, Gram stain and culture, cytology, triglyceride, cholesterol, amylase, and PCT were collected. Data on serum LDH, protein, albumin, prothrombin time, normalized, and blood culture were also collected. Pleural effusions were classified into 2 groups, infectious and noninfectious. There were 18 infectious pleural effusions (IPE) and 57 noninfectious pleural effusions (NIPE). Median pleural fluid PCT was 1.088 ng/mL (0.312-2.940 ng/mL) in IPE and 0.123 ng/mL (0.05-0.263 ng/mL) in NIPE, with a P value 0.25 ng/mL had a sensitivity of 77.78% and specificity of 74.14% for diagnosing an IPE. A subgroup analysis of PCT in exudative infectious effusions versus exudative noninfectious malignant/paramalignant effusions showed higher levels in the former. PCT is a novel biomarker for diagnosing infectious pleural effusion, and it would be worthwhile to investigate the role of pleural PCT in assessing severity of illness, risk stratification, and antibiotic stewardship in hospitalized patients with pleural effusions. Journal of Hospital Medicine 2016;11:363-365. 2016 Society of Hospital Medicine. PMID:26821368

  7. Procalcitonin, MR-Proadrenomedullin, and Cytokines Measurement in Sepsis Diagnosis: Advantages from Test Combination

    Silvia Angeletti

    2015-01-01

    Full Text Available Background. Elevated cytokines levels correlate with sepsis severity and mortality but their role in the diagnosis is controversial, whereas Procalcitonin (PCT has been largely used. Recently, the mid-regional proadrenomedullin (MR-proADM has been combined with PCT for diagnosis optimization. In this study the combined measurement of PCT, MR-proADM, and cytokines in patients with sepsis was evaluated. Methods. One hundred and four septic patients and 101 controls were enrolled. Receiver operating characteristic (ROC analysis and multiple logistic regression were used to evaluate applicant markers for sepsis diagnosis. Markers with best Odds Ratio (OR were combined, and the posttest probability and a composite score were computed. Results. Based upon ROC curves analysis, PCT, MR-proADM, IL-6, IL-10, TNF-α, and MCP-1 were considered applicant for sepsis diagnosis. Among these PCT, MR-proADM , IL-6, and TNF-α showed the best OR. A better posttest probability was found with the combination of PCT with MR-proADM and PCT with IL-6 or TNF-α compared to the single marker. A composite score of PCT, MR-proADM, and TNF-α showed the best ROC curve in the early diagnosis of sepsis. Conclusion. The combination of PCT with other markers should expedite diagnosis and treatment of sepsis optimizing clinical management.

  8. Serum C-Reactive Protein and Procalcitonin Kinetics in Patients Undergoing Elective Total Hip Arthroplasty

    Sandra Battistelli

    2014-01-01

    Full Text Available Background. The sensitivity and the specificity of different methods to detect periprosthetic infection have been questioned. The current study aimed to investigate the kinetics of C-reactive protein (CRP and procalcitonin (PCT in patients undergoing uncomplicated elective total hip arthroplasty (THA, to provide a better interpretation of their levels in noninfectious inflammatory reaction. Methods. A total of 51 patients were included. Serum CRP and PCT concentrations were obtained before surgery, on the 1st, 3rd, and 7th postoperative days and after discharge on the 14th and 30th days and at 2 years. Results. Both markers were confirmed to increase after surgery. The serum CRP showed a marked increase on the 3rd postoperative day while the peak of serum PCT was earlier, even if much lower, on the first day. Then, they declined slowly approaching the baseline values by the second postoperative week. PCT mean values never exceed concentrations typically related to bacterial infections. Conclusions. CRP is very sensitive to inflammation. It could be the routine screening test in the follow-up of THA orthopaedic patients, but it should be complemented by PCT when there is the clinical suspicion of periprosthetic infection.

  9. Induction of procalcitonin in liver transplant patients treated with anti-thymocyte globulin

    Zazula, Roman; Prucha, Miroslav; Tyll, Tomas; Kieslichova, Eva

    2007-01-01

    Introduction The aim of this study was to compare the early postoperative kinetics of procalcitonin (PCT) and C-reactive protein (CRP) serum levels in patients undergoing orthotopic liver transplantation (OLTx) with different immunosuppressive regimens. Methods PCT and CRP serum concentrations were measured in a group of 28 OLTx recipients before induction of anesthesia, at 4 and 8 hours following graft reperfusion, and daily until postoperative day 4. The same parameters were determined in 12 patients undergoing liver resection without conjunctive immunosuppressive therapy. Summary data are expressed as medians and ranges. Two-tailed nonparametric tests were performed and considered significant at p values of less than 0.05. Results The highest serum levels of PCT (median 3.0 ng/mL, minimum 1.4 ng/mL, maximum 13.9 ng/mL) were found in patients after OLTx without ATG therapy, on postoperative day 1. In patients with ATG administration, PCT levels were highly increased on postoperative day 1 (median 53.0 ng/mL, minimum 7.9 ng/mL, maximum 249.1 ng/mL). Thereafter, PCT values continuously decreased independently of further ATG administration in both groups of patients. No evidence of infection was present in either group. In 12 patients undergoing liver resection, peak serum PCT levels did not exceed 3.6 ng/mL. CRP serum levels in a group of patients with and without ATG therapy increased significantly on postoperative day 1, followed by a decrease. The highest levels of CRP were found in patients after liver resection on postoperative day 2 and decreased thereafter. Conclusion ATG administration to patients with OLTx is associated with an increase in serum PCT levels, with peak values on postoperative day 1, and this was in the absence of any evidence of infection. The results of this study indicate that ATG immunosuppressive therapy is a stimulus for the synthesis of PCT. PMID:18088403

  10. 血清降钙素原在败血症早期诊断中的应用价值%The application value of serum procalcitonin in early diagnosis of sepsis

    张昌武

    2015-01-01

    目的:探讨血清降钙素原在败血症早期诊断中的应用价值. 方法:随机选取2012年11月至2014年2月就诊治疗的60例败血症患者作为观察组,并以同期的60例健康体检者作为对照组,检测并比较两组血清降钙素原水平. 结果:观察组患者的血清降钙素原水平为(4.57 ±1.32)ng/mL,对照组为(0.19 ±0.08)ng/mL,观察组患者的血清降钙素原水平高于对照组( P<0. 05). 结论:血清降钙素原水平检测对于败血症的早期诊断有很好的临床应用价值.%Objective:To explore and evaluate the application value of serum procalcitonin in early diagnosis of sepsis. Methods:60 patients with sepsis treated from November 2012 to February 2014 were randomly selected as the research objects of the observation group, and 60 patients examined healthy of the same period as the control group, with the level of serum procalcitonin detected and compared be-tween the two groups. Results:The average level of serum procalcitonin in the observation group was (4. 57 ± 1. 32) ng/mL, which was significantly higher than that of the control group (0. 19 ± 0. 08) ng/mL ( P <0. 05). Conclusion:The detection of serum procalcitonin level is of high value in clinical application for the early diagnosis of sepsis.

  11. The Clinical Application of Procalcitonin%降钙素原的临床应用

    左新; 赖晓东

    2015-01-01

    降钙素原20世纪90年代第一次在脓毒症的患者中被检测到,从此对降钙素原的研究越来越多。近年来,随着科学研究的增多,降钙素原在临床疾病诊治中的应用越来越多,降钙素原逐渐成为感染的判断以及抗生素合理应用的参考指标,同时还发现降钙素原对胰腺炎、术后感染、创伤、脑膜炎等疾病的诊治具有一定的参考价值。本文主要针对降钙素原的生化特点、临床检测及临床应用作一综述。%Procalcitonin was detected in the 1990s for the first time in the patients with sepsis,then the researches about procalcitonin were becoming more and more in recent years.With the increase of scientific research,procalcitonin has got more and more application in clinical diagnosis and treatment of diseases,the procalcitonin has become the reference index of the judgment of the infection and the reasonable use of antibiotics gradually, people also found the value of procalcitonin about diagnosis and treatment on the pancreatitis,postoperative infection,trauma,meningitis.This article mainly aims at the biochemical characteristics,clinical testing and clinical application of procalcitonin.

  12. Procalcitonin and Pentraxin-3: Current biomarkers in inflammation in white coat hypertension.

    Yavuzer, H; Cengiz, M; Yavuzer, S; Rıza Altıparmak, M; Korkmazer, B; Balci, H; Yaldıran, A L; Uzun, H

    2016-07-01

    An association has been described between inflammation and the progression of hypertension (HT) and is shown with several biochemical parameters. Our aim was to examine the distribution of the serum procalcitonin (PCT), pentraxin (PTX)-3 and interleukin (IL)-33 levels and their relationship with carotid intima-media thickness (CIMT) in subjects with white coat HT (WCH), HT and normotension (NT) groups. Thirty-three patients with HT, 33 patients with WCH and 33 healthy subjects were enrolled in this study. PCT, PTX-3 and C-reactive protein (CRP) levels significantly increased in the HT group compared with the NT group. In addition, PCT and CRP levels were significantly higher in the WCH group than in the NT group. CIMT measurements were significantly higher in the WCH and HT groups than in the NT group. In the HT and WCH groups, there were significant positive correlations between PTX-3, PCT and CRP. In the WCH group, PTX-3 and PCT levels were significantly positively correlated with CIMT. PCT had area under the curve value of 0.817 which demonstrates its sufficiency to distinguish WCH from NT individuals. Our results suggest that in subjects with WCH and HT, which are characterized by increased cardiovascular risk, PTX-3 and PCT levels in the HT group and PCT levels in the WCH group are significantly and consistently higher than normotensives. Systemic inflammation moderately occurs in the WCH and HT groups. PCT monitoring may be a useful biomarker in inflammation related to atherosclerosis and early stage HT. PMID:26040439

  13. 血清降钙素原对细菌性肺炎与肺结核鉴别的临床意义分析%Clinical significance analysis of serum procalcitonin for identification of bacterial pneumonia and ;pulmonary tuberculosis

    王雯

    2015-01-01

    Objective To explore the clinical significance of serum procalcitonin (PCT) for identifica-tion of bacterial pneumonia and pulmonary tuberculosis. Methods Serum samples of 21 patients with bacterial pneumonia (pneumonia group) and 22 patients with pulmonary tuberculosis (tuberculosis group) in the same pe-riod were collected. Their serum procalcitonin levels were detected by immumofluorescence method within 24 h after hospitalization for analysis and comparison. Results The pneumonia group had remarkably higher level of serum procalcitonin than the tuberculosis group, and the difference had statistical significance (P<0.05). Conclusion Detection of serum procalcitonin has important significance for identification of bacterial pneumonia and pulmonary tuberculosis.%目的:探讨血清降钙素原(PCT)测定对鉴别诊断细菌性肺炎与肺结核的临床意义。方法收集同期入院诊断为细菌性肺炎患者(肺炎组)21例及肺结核患者(结核组)22例的血清标本,入院24 h内采用免疫荧光法分别测定两组患者的血清降钙素原水平,进行分析比较。结果肺炎组血清降钙素原水平显著高于结核组,差异有统计学意义(P<0.05)。结论血清降钙素原测定对鉴别诊断细菌性肺炎和肺结核具有重要的临床意义。

  14. Value of procalcitonin, C-reactive protein, and neopterin in exacerbations of chronic obstructive pulmonary disease

    Alicia Lacoma

    2011-02-01

    Full Text Available Alicia Lacoma1,4, Cristina Prat1,4, Felipe Andreo2,4, Luis Lores3, Juan Ruiz-Manzano2,4, Vicente Ausina1,4, Jose Domínguez1,41Servei de Microbiologia, 2Servei de Pneumologia, Hospital Universitari Germans Trias i Pujol, Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain; 3Servei de Pneumologia, Hospital de Sant Boi, Sant Boi de Llobregat, Spain; 4CIBER Enfermedades Respiratorias (CIBERES, Instituto de Salud Carlos III, Madrid, SpainObjective: The identification of biological markers in order to assess different aspects of COPD is an area of growing interest. The objective of this study was to investigate whether levels of procalcitonin (PCT, C-reactive protein (CRP, and neopterin in COPD patients could be useful in identifying the etiological origin of the exacerbation and assessing its prognosis.Methods: We included 318 consecutive COPD patients: 46 in a stable phase, 217 undergoing an exacerbation, and 55 with pneumonia. A serum sample was collected from each patient at the time of being included in the study. A second sample was also collected 1 month later from 23 patients in the exacerbation group. We compared the characteristics, biomarker levels, microbiological findings, and prognosis in each patient group. PCT and CRP were measured using an immunofluorescence assay. Neopterin levels were measured using a competitive immunoassay.Results: PCT and CRP showed significant differences among the three patient groups, being higher in patients with pneumonia, followed by patients with exacerbation (P < 0.0001. For the 23 patients with paired samples, PCT and CRP levels decreased 1 month after the exacerbation episode, while neopterin increased. Neopterin showed significantly lower levels in exacerbations with isolation of pathogenic bacteria, but no differences were found for PCT and CRP. No significant differences were found when comparing biomarker levels

  15. Nanoimprinted nanopillar array chip for procalcitonin detection (Conference Presentation)

    Sun, Ling Ling; Zhou, Xiaodong

    2016-03-01

    Procalcitonin (PCT) is an early and highly specific biomarker in response to bacterial infection. The PCT-guided antibiotic therapy has demonstrated to be more efficient than standard therapy to reduce in antibiotic use without adverse outcome in mortality. The PCT detection in clinics is required to be highly sensitive with a sensitivity of 0.5 ng/ml. At present, the technologies for PCT detection are limited. This paper reported a highly sensitive nanoimprinted gold nanopillar array chip for PCT detection. To achieve high sensitivity for PCT detection, the gold nanopillar array sensing chip was designed by plasmonic simulation and fabricated by high fidelity nanoimprinting technology. The gold nanopillars of 140 nm were nanoimprinted on glass substrate. A robust sandwich bioassay of capture antibody /PCT / quantum dot (QD) conjugated detection antibody was established on the gold nanopillar array chip to detect PCT. The nanopillars serve as localized surface plasmon resonance (LSPR) generators to enhance the fluorescent emission from QD. A limit of detection (LOD) of 0.5 ng/ml was achieved for PCT detection. This is the first time that PCT is detected with such high sensitivity by LSPR enhanced QD emission. By considering the low-cost, high sensitivity of the bioassay, as well as the inexpensive mass fabrication of the high quality chips, this novel nanoimprinted gold nanopillar array chip is particularly useful for developing a point-of-care system for PCT detection.

  16. Analysis of some sepsis markers: C-reactive protein, Procalcitonin, Osteopontin and suPAR

    Ilaria Crespi

    2010-09-01

    Full Text Available Sepsis appears to be due to an uncontrolled pro and anti-inflammatory response leading to organ dysfunction until shock and death.Accuracy of diagnosis and appropriate treatment affect the outcome. Aim of the study was to investigate if the levels of Osteopontin (OPN and Soluble Urokinase-type Plasminoge Activator Receptor (suPAR might be early markers of sepsis and if these markers play a role in predicting the progression to septic shock. Methods:The levels of OPN, suPAR, C-reactive protein (CRP and procalcitonin (PCT were measured in patients at higher risk of infection. The samples were collected from the day of admission for the following fifteenth day. During recovery Sistemic Inflammatory Response Syndrome (SIRS criteria, blood chemistry data, blood gas- analysis, lactate and diuresis were collected. Microbiological culture were performed according to the clinical condition. Results: 29 patients were enrolled in the study, including 14 subjects with positive blood cultures.The values of OPN, PCT, suPAR and CRP were significantly increased in patients with positive blood cultures than those with negative blood cultures.Analysing changes of the levels of OPN, suPAR, PCT and CRP in patients with septic shock, the values of OPN increased in advance to the clinical diagnosis of septic shock, while the values of suPAR and PCT slight delay compared to those OPN.The levels of CRP were independent from the onset of septic shock state. Conclusions: These preliminary data suggest that Osteopontin and suPAR can be used as early markers of sepsis and might be useful in monitoring of septic outcome to predict a possible evolution to septic shock.

  17. Behavioral Abnormalities in a Mouse Model of Chronic Toxoplasmosis Are Associated with MAG1 Antibody Levels and Cyst Burden.

    Xiao, Jianchun; Li, Ye; Prandovszky, Emese; Kannan, Geetha; Viscidi, Raphael P; Pletnikov, Mikhail V; Yolken, Robert H

    2016-04-01

    There is marked variation in the human response to Toxoplasma gondii infection. Epidemiological studies indicate associations between strain virulence and severity of toxoplasmosis. Animal studies on the pathogenic effect of chronic infection focused on relatively avirulent strains (e.g. type II) because they can easily establish latent infections in mice, defined by the presence of bradyzoite-containing cysts. To provide insight into virulent strain-related severity of human toxoplasmosis, we established a chronic model of the virulent type I strain using outbred mice. We found that type I-exposed mice displayed variable outcomes ranging from aborted to severe infections. According to antibody profiles, we found that most of mice generated antibodies against T. gondii organism but varied greatly in the production of antibodies against matrix antigen MAG1. There was a strong correlation between MAG1 antibody level and brain cyst burden in chronically infected mice (r = 0.82, p = 0.0021). We found that mice with high MAG1 antibody level displayed lower weight, behavioral changes, altered levels of gene expression and immune activation. The most striking change in behavior we discovered was a blunted response to amphetamine-trigged locomotor activity. The extent of most changes was directly correlated with levels of MAG1 antibody. These changes were not found in mice with less cyst burden or mice that were acutely but not chronically infected. Our finding highlights the critical role of cyst burden in a range of disease severity during chronic infection, the predictive value of MAG1 antibody level to brain cyst burden and to changes in behavior or other pathology in chronically infected mice. Our finding may have important implications for understanding the heterogeneous effects of T. gondii infections in human. PMID:27124472

  18. Thymidine kinase 2 deficiency-induced mitochondrial DNA depletion causes abnormal development of adipose tissues and adipokine levels in mice.

    Joan Villarroya

    Full Text Available Mammal adipose tissues require mitochondrial activity for proper development and differentiation. The components of the mitochondrial respiratory chain/oxidative phosphorylation system (OXPHOS are encoded by both mitochondrial and nuclear genomes. The maintenance of mitochondrial DNA (mtDNA is a key element for a functional mitochondrial oxidative activity in mammalian cells. To ascertain the role of mtDNA levels in adipose tissue, we have analyzed the alterations in white (WAT and brown (BAT adipose tissues in thymidine kinase 2 (Tk2 H126N knockin mice, a model of TK2 deficiency-induced mtDNA depletion. We observed respectively severe and moderate mtDNA depletion in TK2-deficient BAT and WAT, showing both tissues moderate hypotrophy and reduced fat accumulation. Electron microscopy revealed altered mitochondrial morphology in brown but not in white adipocytes from TK2-deficient mice. Although significant reduction in mtDNA-encoded transcripts was observed both in WAT and BAT, protein levels from distinct OXPHOS complexes were significantly reduced only in TK2-deficient BAT. Accordingly, the activity of cytochrome c oxidase was significantly lowered only in BAT from TK2-deficient mice. The analysis of transcripts encoding up to fourteen components of specific adipose tissue functions revealed that, in both TK2-deficient WAT and BAT, there was a consistent reduction of thermogenesis related gene expression and a severe reduction in leptin mRNA. Reduced levels of resistin mRNA were found in BAT from TK2-deficient mice. Analysis of serum indicated a dramatic reduction in circulating levels of leptin and resistin. In summary, our present study establishes that mtDNA depletion leads to a moderate impairment in mitochondrial respiratory function, especially in BAT, causes substantial alterations in WAT and BAT development, and has a profound impact in the endocrine properties of adipose tissues.

  19. Role of Procalcitonin and Interleukin-6 in Predicting Cancer, and Its Progression Independent of Infection.

    Anne-Marie Chaftari

    Full Text Available Procalcitonin (PCT and Interleukin-6 (IL-6 have emerged as biomarkers for different inflammatory conditions. The purpose of the study was to evaluate the role of PCT and IL-6 as biomarkers of cancer and its progression in a large cohort of patients. This cross-sectional study included residual plasma samples collected from cancer patients, and control subjects without cancer. Levels of PCT and IL-6 were determined by Kryptor compact bioanalyzer. We identified 575 febrile cancer patients, 410 non-febrile cancer patients, and 79 non-cancer individuals. The median PCT level was lower in control subjects (0.029 ng/ml compared to cancer patients with stage I-III disease (0.127 ng/ml (p<0.0001 and stage IV disease (0.190 ng/ml (p<0.0001. It was also higher in febrile cancer patients (0.310 ng/ml compared to non-febrile cancer patients (0.1 ng/ml (p<0.0001. Median IL-6 level was significantly lower in the control group (0 pg/ml than in non-febrile cancer patients with stages I-III (7.376 pg/ml or stage IV (9.635 pg/ml (p<0.0001. Our results suggest a potential role for PCT and IL-6 in predicting cancer in non-febrile patients. In addition, PCT is useful in detecting progression of cancer and predicting bacteremia or sepsis in febrile cancer patients.

  20. The Diagnostic Value of D-dimer, Procalcitonin and CRP in Acute Appendicitis

    Bulent Kaya, Baris Sana, Cengiz Eris, Koray Karabulut, Orhan Bat, Riza Kutanis

    2012-01-01

    Full Text Available BACKGROUND: The early diagnosis of acute abdomen is of great importance. To date, several inflammatory markers have been used for the diagnosis of acute abdominal conditions, including acute appendicitis. The aim of this study was to evaluate the diagnostic utility of D-dimer, Procalcitonin (PCT and C-reactive protein (CRP measurements in the acute appendicitis.METHODS: This prospective study was conducted between March 1st, 2010 and July 1st, 2011. In this period, seventy-eight patients were operated with the diagnosis of acute appendicitis, and D-dimer, PCT and CRP levels of the patients were measured. The patients were grouped as phlegmonous appendicitis (Group 1, gangrenous appendicitis (Group 2, perforated appendicitis (Group 3 and negative appendectomy (Group 4 according to the surgical findings and histopathological results.RESULTS: Of 78 patients, 54 (69.2 % were male and 24 (30.8 % were female, and the mean age was 25.4 ± 11.1 years (range, 18 to 69 years. 66 (84.6 % patients had increased leukocyte count (white blood cell count. The PCT values were higher than the upper normal limit in 20 (25.6% patients, followed by D-dimer in 22 (28.2 % patients and CRP in 54 (69.2 % patients. The diagnostic value of leukocyte count and CRP in acute appendicitis was higher than that of the other markers, whereas leukocyte count showed very low specificity. CRP values were higher in perforated appendicitis when compared with the phlegmonous appendicitis (p<0.05. However, PCT and D-dimer showed lower diagnostic values (26% and 31%, respectively.CONCLUSION: An increase in CRP levels alone is not sufficient to make the diagnosis of acute appendicitis. However, CRP levels may differentiate between phlegmonous appendicitis and perforated appendicitis. Due to their low sensitivity and diagnostic value, PCT and D-dimer are not better markers than CRP for the diagnosis of acute appendicitis.

  1. Level of cytogenetic damage and morphological abnormalities in peripheral blood erythrocytes of fish from the Techa river

    Low-level radioactive waste had been releasing to the Techa River from 1949 to 1956. Now it is a suitable water system to study the potential effect of chronic low level exposure of radiation. During that period over 76 million m3 of waste water was released into the river with total activity of 1.1 *1017 Bq. In 2012 we examined the erythrocytes in peripheral blood of fish (roach, perch, pike), inhabiting different part of the Techa River (Russia, Chelyabinsk region). Sampling was conducted twice a year (in May during spawning, and in August during feeding) at three stations with various levels of radioactive contamination: Station RT1 in the upper reach of the Techa River, station RT2 in the middle reach and station RT3 in the lower reach of the river. Determination of radionuclide concentrations in water, bottom sediments and fish was performed. An average above-background content of 90Sr in the body of fish inhabiting the Techa River is given in the table. Fish from the nearby Miass River was used as a control group. Blood was taken from the tail vein of live fish for the preparation of smears for determination of cytogenetic damage levels. 3,000 erythrocytes were analyzed for each fish on microscope Axioskop 50 (Carl Zeiss). Regression analyses found out significant dependency of the frequency of erythrocytes with micronuclei in blood on the burden of 90Sr in the body of roach in the summer period (F1,32=4.6; p=0.04). The given data do not allow excluding the genotoxic influence of radiation on fish. Another important effect is an increase in the frequency of erythrocytes with cell division pathology: with an increase of the burden of 90Sr in the body, an increase in the frequency of amitoses and the sum of division pathologies are noted in the body. Regression analyses indicated a significant dependency of these parameters on the burden of 90Sr in the body of fish (for the frequency of amitoses F1,199=6.3, p=0.01; for the frequency of pathology division

  2. Hepatic ischemia-reperfusion syndrome after partial liver resection (LR): hepatic venous oxygen saturation, enzyme pattern, reduced and oxidized glutathione, procalcitonin and interleukin-6.

    Kretzschmar, Michael; Krüger, Antie; Schirrmeister, Wulf

    2003-06-01

    The hepatic ischemia-reperfusion syndrome was investigated in 28 patients undergoing elective partial liver resection with intraoperative occlusion of hepatic inflow (Pringle maneuver) using the technique of liver vein catheterization. Hepatic venous oxygen saturation (ShvO2) was monitored continuously up to 24 hours after surgery. Aspartate aminotransferase, glutamate dehydrogenase, gamma-glutamyl transpeptidase, pseudocholinesterase, alpha-glutathione S-transferase, reduced and oxidized glutathione, procalcitonine, and interleukin-6 were serially measured both before and after Pringle maneuver during the resection and postoperatively in arterial and/or hepatic venous blood. ShvO2 measurement demonstrated that peri- and postoperative management was suitable to maintain an optimal hepatic oxygen supply. As expected, we were able to demonstrate a typical enzyme pattern of postischemic liver injury. There was a distinct decrease of reduced glutathione levels both in arterial and hepatic venous plasma after LR accompanied by a strong increase in oxidized glutathione concentration during the phase of reperfusion. We observed increases in procalcitonin and interleukin-6 levels both in arterial and hepatic venous blood after declamping. Our data support the view that liver resection in man under conditions of inflow occlusion resulted in ischemic lesion of the liver (loss of glutathione synthesizing capacity with disturbance of protection against oxidative stress) and an additional impairment during reperfusion (liberation of reactive oxygen species, local and systemic inflammation reaction with cytokine production). Additionally, we found some evidence for the assumption that the liver has an export function for reduced glutathione into plasma in man. PMID:12877355

  3. 腹水及血浆降钙素原在肝硬化合并自发性细菌性腹膜炎诊断中的价值%Values of ascites and plasma procalcitonin in diagnosis of liver cirrhosis with spontaneous bacterial peritonitis

    党燕; 张立丽; 娄金丽; 陈铭

    2015-01-01

    Objective To explore the clinical value of ascites and plasma procalcitonin examination in early diagnosis of liver cirrhosis with spontaneous bacterial peritonitis( SBP) . Methods Totally 69 cirrhotic patients with ascites including 28 patients with spontaneous bacterial peritonitis and 41 patients without spontaneous bacterial peritonitis seen in Beijing Youan Hospital from August, 2014 to January, 2015 were studied. The levels of ascites and plasma procalcitonin of these patients were analyzed. Results The levels of procalcitonin, white blood cell counts in plasma and procalcitonin, white blood cell, polymorphonuclear leucocytes counts in ascites in SBP group were significantly higher than those in the non-SBP group(P<0. 01). The procalcitonin levels in ascites and plasma were positively correlated(r=0. 877, P<0. 01). ROC curve analysis showed that the areas under curve of ascites and plasma procalcitonin were 0. 919 and 0. 820;meanwhile the best thresholds were 0. 415 and 0. 746 ng/mL respectively. Conclusion Detections of ascites and plasma procalcitonin have significant value for the early diagnosis of liver cirrhosis patients with spontaneous bacterial peritonitis, it has high sensitivity and specificity, and the diagnostic value of plasma procalcitonin is superior to ascites procalcitonin.%目的:探讨腹水及血浆降钙素原在肝硬化合并自发性细菌性腹膜炎( spontaneous bacterial peritonitis,SBP)诊断中的价值,为其早期诊断提供依据。方法选取首都医科大学附属北京佑安医院2014年8月至2015年1月肝硬化腹水患者69例,其中确诊合并自发性细菌性腹膜炎的28例,未合并自发性细菌性腹膜炎的41例,进行腹水及血浆降钙素原水平检测,并进行相关统计分析。结果与非SBP组相比,SBP组腹水降钙素原( procalcitonin,PCT)、腹水白细胞( white blood cell,WBC)、腹水多形核细胞(polymorphonuclear,PMN)和血浆PCT、全血WBC检测结果均显著升

  4. Pro/Con debate: Is procalcitonin useful for guiding antibiotic decision making in critically ill patients?

    Shehabi, Yahya; Seppelt, Ian

    2008-01-01

    You are concerned about the escalating use of antibiotics in your intensive care unit (ICU). This has put a strain on the ICU budget and is possibly resulting in the emergence of resistant bacteria. You review the situation with your team and one suggestion is to consider using biomarkers such as procalcitonin to better guide appropriate antibiotic decision making. PMID:18466649

  5. Guiding of serum procalcitonin-guided antibiotic in elderly early-onset stroke-associated pneumonia

    龙威

    2013-01-01

    Objective To evaluate the effects of serum procalcitonin (PCT) -guided antibiotic therapy in elderly patients with early-onset stroke-associated pneumonia (EOP) .Methods Totally 179 eligible elderly patients with EOP were randomly devided into 2 groups:standard therapy

  6. Procalcitonin and C-reactive protein as markers of bacterial infection in patients with solid tumours

    Diness, Laura V; Maraldo, Maja V; Mortensen, Christiane E;

    2014-01-01

    infection. In this prospective study, we wanted to investigate the value of procalcitonin (PCT) compared with C-reactive protein (CRP) as an indicator of bacterial infection in adult patients with solid tumours. METHODS: A total of 41 patients with solid tumours admitted to hospital due to fever or clinical...

  7. Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro

    Nijsten, MWN; Olinga, P; The, TH; de Vries, EGE; Groothuis, GMM; Limburg, PC; ten Duis, HJ; Moshage, H; Hoekstra, HJ; Bijzet, J; Zwaveling, JH; Schraffordt Koops, H.

    2000-01-01

    Objectives: Procalcitonin (PCT) is a 13 kD protein of which plasma concentrations are strongly increased in inflammatory states, PCT concentrations are claimed to have a more powerful discriminatory value for bacterial infection than the acute phase proteins serum amyloid A (SAA) or C-reactive prote

  8. Additional value of procalcitonin for diagnosis of infection in patients with fever at the emergency department

    M.D. de Kruif; M. Limper; H. Gerritsen; C.A. Spek; D.P.M. Brandjes; H. ten Cate; P.M. Bossuyt; P.H. Reitsma; E.C.M. van Gorp

    2010-01-01

    Objective: First, to determine whether procalcitonin (PCT) significanty adds diagnostic value in terms of sensitivity and specificity to a common set of markers of infection, including C-reactive protein (CRP), at the Emergency Department. Second, to create a simple scoring rule implementing PCT val

  9. Level of cytogenetic damage and morphological abnormalities in peripheral blood erythrocytes of fish from the Techa river

    Tryapitsina, G. [Urals Research Center for Radiation Medicine - URCRM, Chelyabinsk State University (Russian Federation); Shaposhnikova, I. [Urals Research Center for Radiation Medicine - URCRM (Russian Federation); Rudolfsen, G. [Norwegian Radiation Protection Authority - NRPA, and University of Tromsoe (Norway); Obvintseva, N.; Pryakhin, E. [Urals Research Center for Radiation Medicine (Russian Federation); Akleyev, A. [Urals Research Center for Radiation Medicine and Chelyabinsk State University (Russian Federation)

    2014-07-01

    Low-level radioactive waste had been releasing to the Techa River from 1949 to 1956. Now it is a suitable water system to study the potential effect of chronic low level exposure of radiation. During that period over 76 million m{sup 3} of waste water was released into the river with total activity of 1.1 *10{sup 17} Bq. In 2012 we examined the erythrocytes in peripheral blood of fish (roach, perch, pike), inhabiting different part of the Techa River (Russia, Chelyabinsk region). Sampling was conducted twice a year (in May during spawning, and in August during feeding) at three stations with various levels of radioactive contamination: Station RT1 in the upper reach of the Techa River, station RT2 in the middle reach and station RT3 in the lower reach of the river. Determination of radionuclide concentrations in water, bottom sediments and fish was performed. An average above-background content of {sup 90}Sr in the body of fish inhabiting the Techa River is given in the table. Fish from the nearby Miass River was used as a control group. Blood was taken from the tail vein of live fish for the preparation of smears for determination of cytogenetic damage levels. 3,000 erythrocytes were analyzed for each fish on microscope Axioskop 50 (Carl Zeiss). Regression analyses found out significant dependency of the frequency of erythrocytes with micronuclei in blood on the burden of {sup 90}Sr in the body of roach in the summer period (F{sub 1,32}=4.6; p=0.04). The given data do not allow excluding the genotoxic influence of radiation on fish. Another important effect is an increase in the frequency of erythrocytes with cell division pathology: with an increase of the burden of {sup 90}Sr in the body, an increase in the frequency of amitoses and the sum of division pathologies are noted in the body. Regression analyses indicated a significant dependency of these parameters on the burden of {sup 90}Sr in the body of fish (for the frequency of amitoses F{sub 1,199}=6.3, p=0

  10. The correlation study of procalcitonin and C- reactive protein with children's bloodstream infections%降钙素原、C-反应蛋白与儿童血流感染的相关性研究

    余烈中; 彭伟媛; 何静文; 赖挺方

    2016-01-01

    Objective To study the correlation of procalcitonin with children's bloodstream infections. Methods 300 cases of suspected bloodstream infections children in author hospital were selected,where simultaneous blood cultures and procalcitonin detected as research subjects.Comparison of two groups of children of serum procalcitonin levels,C- reactive protein levels,serum procalcitonin levels Gram bacteria cases between yin and yang. Results Children with blood culture-negative serum procalcitonin group,C- reactive protein and blood mean level culture positive infants compared, they had significant differences(P 0.05). Conclusion The serum procalcitonin level cloud be used as an early auxiliary diagnosis in bacterial infection, which may be conducive to implement antibiotic therapy.Meanwhile,the serum procalcitonin level cloud provide evidence for antibiotic therapy to avoid abuse of antibiotics.%目的:分析血清降钙素原与儿童血流感染之间的相关性。方法选择笔者所在医院同时进行血培养和降钙素原检测的300例疑似血流感染患儿为研究对象。比较两组患儿的血清降钙素原水平、C-反应蛋白水平及革兰阴阳菌病例间的血清降钙素原水平。结果血培养阴性组患儿的血清降钙素原、C-反应蛋白的均值水平与血培养阳性组患儿相比,差异有统计学意义(P<0.05)。革兰阳性菌49株(74.24%),革兰阴性菌17株(25.76%);革兰阳性菌组患者血清降钙素原均值水平显著低于格兰阴性菌组。两组菌株、血清降钙素原水平比较差异有统计学意义(P<0.05);C-反应蛋白比较差异不显著,差异无统计学意义(P>0.05)。结论血清血降钙素原水平可作为临床早期诊断细菌感染的辅助指标,从而及时有效地实施抗菌药物治疗。同时,血清降钙素原水平还可为抗菌药物应用提供有效的参照标准,对避免抗菌药物滥用具有重要的现实意义。

  11. Procalcitonin versus C-reactive protein for predicting pneumonia in adults with lower respiratory tract infection in primary care

    Holm, Anette; Pedersen, Svend S; Nexoe, Joergen;

    2007-01-01

    BACKGROUND: The role of procalcitonin in diagnosing bacterial infection has mainly been studied in patients with severe infections. There is no study on the value of procalcitonin measurements in adults with lower respiratory tract infection (LRTI) treated in primary care. AIM: To evaluate the...... accuracy of plasma procalcitonin in predicting radiographic pneumonia, bacterial infection, and adverse outcome in a population of adults with LRTI treated in primary care. DESIGN OF STUDY: Prospective, observational study. SETTING: Forty-two general practices and an outpatient clinic at the Department of...... Infectious Diseases, Odense University Hospital, Denmark. METHOD: A total of 364 patients with LRTI were prospectively enrolled from 42 general practices. Patients were examined with chest radiography, microbiological analyses, and measurements of C-reactive protein (CRP) and procalcitonin. The outcome...

  12. Procalcitonin-guided antibiotic treatment of respiratory tract infections in a primary care setting: are we there yet?

    Aabenhus, R.; Jensen, J.U.

    2011-01-01

    , could greatly improve patient care and limit excessive antibiotic prescriptions. Procalcitonin is a new marker of suspected bacterial infection that has shown promise in guiding antibiotic therapy in acute respiratory tract infections in hospitals without compromising patient safety. Procalcitonin......-of-care test for procalcitonin with acceptable precision, severely hampering its application in primary care. This article reviews the physiology of procalcitonin, describes the assays available for its measurement, evaluates the present evidence from primary care on its use to identify correctly patients who......Clinical signs of infection do not allow for correct identification of bacterial and viral aetiology in acute respiratory infections. A valid tool to assist the clinician in identifying patients who will benefit from antibiotic therapy, as well as patients with a potentially serious infection...

  13. Clinical Applications of Procalcitonin in Pediatrics: An Advanced Biomarker for Inflammation and Infection—Can It Also Be Used in Trauma?

    Koutroulis, Ioannis; Loscalzo, Steven M.; Kratimenos, Panagiotis; Singh, Sabina; Weiner, Evan; Syriopoulou, Vassiliki; Theocharis, Stamatios; Chrousos, Georgios

    2014-01-01

    Background. Procalcitonin is a small molecular peptide that has gained increased support as an adjunct diagnostic marker of infection in the adult population; the concordant body of evidence for the use of procalcitonin in pediatric populations is far less complete. Objectives. Our objective is to review the current evidence supporting the utilization of procalcitonin in children in a variety of clinical scenarios including SIRS, sepsis, burns, and trauma and to identify existing knowledge ga...

  14. Correlation between Procalcitonin and the Degree of Atherosclerotic Lesions%降钙素原与冠状动脉粥样硬化病变程度相关性分析

    莫艳霞; 万翔

    2015-01-01

    目的:探讨降钙素原与冠状动脉粥样硬化( CAS)病变程度间的相关性。方法选择2012年1月至2014年1月仙桃市第一人民医院心血管内科收治的CAS患者100例为病例组,均行临床冠状动脉造影检查,并选择同期疑似CAS且经冠状动脉造影检查正常者100例为对照组,两组患者均在冠状动脉造影检查同时抽取静脉血进行降钙素原和高敏 C 反应蛋白(hs-CRP)水平检测;根据冠状动脉造影结果对病例进行分级,比较各疾病亚组之间的降钙素原和 hs-CRP水平。结果与对照组比较,病例组降钙素原 hs-CRP 水平均显著升高[(360±69)μg/L 比(50±10)μg/L,(45.59±11.25) mg/L比(1.33±0.11) mg/L,P<0.05]。随着CAS的加重,降钙素原逐渐升高;各疾病亚组间比较差异有统计学意义( P<0.05)。结论降钙素原可作为 CAS分级较理想的指标,与 hs-CRP联合诊断,有更高的临床应用价值。%Objective To investigate the relationship between procalcitonin and atherosclerotic lesions . Methods A total of 100 cases with coronary heart disease in Xiantao First People′s Hospital from Jan.2012 to Jan.2014 were chosen as the experimental group, and 100 cases with suspected coronary heart disease but normal coronary angiography, were chosen as control group.The serum procalcitonin and high sensitivity C reactive protein( hs-CRP) level were detected.According to coronary angiography result, the patients were graded into different levels( subgroups) ,and the procalcitonin and hs-CRP level of different subgroups were compared.Results The serum procalcitonin and hs-CRP level of the observation group were significantly higher than those in the control group[(360 ±69)μg/L vs (50 ±10) μg/L,(45.59 ±11.25) mg/L vs (1.33 ±0.11) mg/L,P<0.05].The procalcitonin and hs-CRP level increased with the severity of CAS (P<0.05).And the differences between the different

  15. Diagnostic accuracy of procalcitonin in critically ill immunocompromised patients

    Legriel Stéphane

    2011-08-01

    Full Text Available Abstract Background Recognizing infection is crucial in immunocompromised patients with organ dysfunction. Our objective was to assess the diagnostic accuracy of procalcitonin (PCT in critically ill immunocompromised patients. Methods This prospective, observational study included patients with suspected sepsis. Patients were classified into one of three diagnostic groups: no infection, bacterial sepsis, and nonbacterial sepsis. Results We included 119 patients with a median age of 54 years (interquartile range [IQR], 42-68 years. The general severity (SAPSII and organ dysfunction (LOD scores on day 1 were 45 (35-62.7 and 4 (2-6, respectively, and overall hospital mortality was 32.8%. Causes of immunodepression were hematological disorders (64 patients, 53.8%, HIV infection (31 patients, 26%, and solid cancers (26 patients, 21.8%. Bacterial sepsis was diagnosed in 58 patients and nonbacterial infections in nine patients (7.6%; 52 patients (43.7% had no infection. PCT concentrations on the first ICU day were higher in the group with bacterial sepsis (4.42 [1.60-22.14] vs. 0.26 [0.09-1.26] ng/ml in patients without bacterial infection, P 0.5 ng/ml had 100% sensitivity but only 63% specificity for diagnosing bacterial sepsis. The area under the receiver operating characteristic (ROC curve was 0.851 (0.78-0.92. In multivariate analyses, PCT concentrations > 0.5 ng/ml on day 1 independently predicted bacterial sepsis (odds ratio, 8.6; 95% confidence interval, 2.53-29.3; P = 0.0006. PCT concentrations were not significantly correlated with hospital mortality. Conclusion Despite limited specificity in critically ill immunocompromised patients, PCT concentrations may help to rule out bacterial infection.

  16. Useulness of B Natriuretic Peptides and Procalcitonin in Emergency Medicine

    P. Ray

    2008-01-01

    Full Text Available Congestive heart failure (CHF is the main cause of acute dyspnea in patients presented to an emergency department (ED, and it is associated with high morbidity and mortality. B-type natriuretic peptide (BNP is a polypeptide, released by ventricular myocytes directly proportional to wall tension, for lowering renin-angiotensin-aldosterone activation. For diagnosing CHF, both BNP and the biologically inactive NT-proBNP have similar accuracy. Threshold values are higher in elderly population, and in patients with renal dysfunction. They might have also a prognostic value. Studies demonstrated that the use of BNP or NT-proBNP in dyspneic patients early in the ED reduced the time to discharge, total treatment cost. BNP and NT-proBNP should be available in every ED 24 hours a day, because literature strongly suggests the beneficial impact of an early appropriate diagnosis and treatment in dyspneic patients. Etiologic diagnosis of febrile patients who present to an ED is complex and sometimes difficult. However, new evidence showed that there are interventions (including early appropriate antibiotics, which could reduce mortality rate in patients with sepsis. For diagnosing sepsis, procalcitonin (PCT is more accurate than C-reactive protein. Thus, because of its excellent specificity and positive predictive value, an elevated PCT concentration (higher than 0.5 ng/mL indicates ongoing and potentially severe systemic infection, which needs early antibiotics (e.g. meningitis. In lower respiratory tract infections, CAP or COPD exacerbation, PCT guidance reduced total antibiotic exposure and/or antibiotic treatment duration.

  17. The clinical application of procalcitonin in diagnosis of pneuminia in children%降钙素原在小儿肺炎诊断中的应用

    蔡美珠; 何凤琼; 曹永东

    2008-01-01

    Objective To analyze the serum level of procalcitonin (PCT) in children with bacte-rial or viral pneumonia, explore its diagnostic value in diagnosis of bacterial pneuminia in children, and so as to provide evidence for clinical use of antibiotics. Methods A total of 42 children with pneumonia(mean age was 5.6 yrs, including 24 boys and 18 girls) were divided into viral neumonia group (n=25) and bacterial neumonia group (n=17). Semi-quantitative solid-phase immunoassay was applied to measuring serum procalcitonin. There were four PCT grades:/0.5 ng/mL、≥2 ng/mL和≥10 ng/mL4个等级,进行x2检验.结果 细菌性肺炎组患儿血清PCT水平高于病毒性肺炎组,差异有显著性意义(P<0.01).结论 血清PCT是小儿细菌性肺炎的敏感标志物之一,血清PCT检测有助于小儿肺炎的诊断及鉴别诊断,可作为临床抗生素的使用依据.

  18. PROCALCITONIN AS A BIOMARKER OF BACTERIAL INFECTION IN SICKLE CELL VASO-OCCLUSIVE CRISIS.

    Dilip Kumar Patel

    2014-02-01

    Full Text Available Bacterial infection is an important trigger of vaso-occlusive crisis (VOC in sickle cell anaemia (SCA. SCA Patients with VOC have signs of inflammation and it is difficult to diagnose bacterial infection in them. This study was undertaken to evaluate serum procalcitonin (PCT as a biomarker of bacterial infection in acute sickle cell vaso-occlusive crisis. Hundred SCA patients were studied at Sickle Cell Clinic and Molecular Biology Laboratory, V.S.S. Medical College, Burla, Odisha, India. SCA was diagnosed by haemoglobin electrophoresis, HPLC and molecular analysis. Patients were divided into 3categories namely Category-A (VOC/ACS with fever but without evidence of bacterial infection-66 patients; Category-B (VOC with fever and documentedbacterial infection-24 patients; and Category-C (Patients in steady statewithout VOC/ACS or fever-10 patients. Investigations like complete blood count, C-reactive protein estimation and PCT measurement was done in all the cases. There was no significant difference in total leucocytes count and C-reactiveprotein values between category A and B. In category A the PCT level was 0.5ng/mL with 87.5% of cases having >2ng/mL. In category C, PCT value was 2ng/mL is indicative of bacterial infection necessitating antimicrobial therapy. Patients with indeterminate PCT value of0.5-2ng/mL, need a repeat PCT estimation or an empirical antibiotic therapyawaiting the availability of microbiological report as deemed necessary.

  19. Procalcitonin: A New Biomarker for Medullary Thyroid Cancer? A Systematic Review.

    Karagiannis, Apostolos K A; Girio-Fragkoulakis, Constantine; Nakouti, Theodora

    2016-08-01

    Medullary thyroid cancer (MTC) is a rare but aggressive thyroid malignancy. The gold-standard biomarker for its diagnosis and follow-up is calcitonin (CT); however, it has a variable half-life dependent on its circadian variability. It has been suggested that a more stable hormone, procalcitonin (PCT), may overcome these problems and its introduction to routine practice may give more accurate results in the diagnosis and follow-up of MTC. We systematically reviewed Pubmed, Scopus, Biosis Previews and Embase databases up to March 2016. A total of 15 out of 184 articles were retrieved and analyzed. Of these 15 studies, 3 were case reports. In these 15 studies, the values of CT and PCT were assessed in both patients with MTC and patients that were either healthy volunteers or with benign/malignant thyroid nodular disease or with bacterial infection. Our search suggests that PCT seems to be a useful biomarker for the diagnosis and follow-up of MTC when used in conjunction with CT, particularly in a small proportion of tumors that are CT-negative or secrete low levels of CT. So far, there has not been enough data to suggest a specific threshold for normal PCT. However, most studies indicate a value of 0.1 ng/ml as an acceptable cut-off in everyday clinical practice. At present, CT should continue to be the primary biomarker in MTC with the addition of PCT in some patient groups. Nevertheless, larger patient series need to be conducted in order to provide safer and more accurate results. PMID:27466480

  20. Test of Serum Procalcitonin Applied to Neonatal Infectious Diseases%降钙素原检测在新生儿感染性疾病中的应用

    杨继英

    2015-01-01

    Objective To investigate the value of serum procalcitonin (PCT) applied to neonatal infectious diseases. Methods 288 neonates hospitalized in Department of Pediatrics of our hospital from December 2013 to December 2014 were divided into severe infection group (64 cases), general infection group (132 cases), non-infected group (92 cases). Electrochemical luminescence method was used to test the level of serum PCT in the neonates. Results Of the 132 cases in the general infection group, 46 cases had positive procalcitonin with the positive rate of 34.85%, 86 cases had negative procalcitonin. Of the 64 cases in the severe in-fection group, 40 cases had positive procalcitonin with the positive rate of 62.5%, 24 cases had negative procalcitonin. Of the 92 cases in the non-infected group, 9 cases had positive procalcitonin with the positive rate of 9.78%, 83 cases had negative procal-citonin. The severe infection group had the highest positive rate of PCT, followed by the general infection group, and the non-in-fected group had the lowest positive rate of PCT with statistically significant difference (P<0.05). The level of PCT in all the neonates decreased as the disease improved with statistically significant difference (P<0.05). Conclusion ①The infection of the neonates and bacterial infection can be effectively identified by testing the level of serum PCT in 288 neonates. ②Many reasons including bacterial infection can cause neonatal pneumonia. PCT testing can be used as the identification index of neonatal infec-tious pneumonia, which provides a theoretical basis for the clinical rational use of antibiotics.%目的 探讨血清降钙素原(PCT)在新生儿感染性疾病应用价值. 方法 将该院儿科2013年12月—2014年12月收治的288例住院新生儿分别归入重症感染组(64例)、一般感染组(132例)、非感染组(92例),采用电化学发光法检测患儿血清降钙素原(PCT)水平变化.结果 一般感染组132例,降钙素原阳性46

  1. The Association between N-terminal Pro-Brain Natriuretic Peptide Levels in the Umbilical Vein and Amniotic Fluid Volume Abnormalities.

    Ersoy, Ali Ozgur; Ozler, Sibel; Oztas, Efser; Ersoy, Ebru; Ergin, Merve; Erkaya, Salim; Uygur, Dilek

    2016-04-01

    Purpose The amniotic fluid volume (AFV) is known as a predictor for the wellness of a fetus. We aimed to investigate whether N-terminal pro-brain natriuretic peptide (NTproBNP) levels reflect AFV abnormalities in otherwise normal fetuses. Methods We recruited 24 women with isolated oligohydramnios, 23 women with isolated polyhydramnios, and 36 women with normal AFV at a tertiary referral center. NT-proBNP levels in umbilical venous samples and the individual characteristics of the three groups were compared. One-way ANOVA and Kruskal-Wallis analysis of variance were used for multi-group comparisons of continuous variables. When a significant difference was detected, the Scheffe test was performed as a post-hoc analysis. Proportions were compared using the Chi-square (χ2) test. Results Maternal age, body mass indices, weight gained in pregnancy and NT-proBNP levels were similar among the three groups. Apgar scores at 1 and 5 minutes significantly correlated with NT-proBNP levels in all newborns (Spearman's r = 0.23; p = 0.03 and Spearman's r = 0.24; p = 0.02, respectively). The umbilical venous NT-proBNP levels did not differ between newborns who needed mechanical ventilation and those who didn't (p = 0.595). Conclusions NT-proBNP is a biomolecule that may provide insights into the pathogenesis of fetal circulatory problems and subsequent renal failure. Further investigations are warranted. PMID:27096950

  2. Using the Procalcitonin and C-reactive Protein in the Diagnosis of Infectious Diseases%血清降钙素原与C反应蛋白对感染性疾病的诊断价值

    苏巧云; 杨凤啸

    2013-01-01

    目的:探讨血清降钙素原(PCT)与c反应蛋白(CRP)对感染性疾病的诊断价值.方法:回顾性分析我院2012年1月至2012年8月间102例确诊为感染性疾病的患者的临床资料,探讨164例患者血清降钙素原及C反应蛋白的水平及其与感染性疾病之间的联系.以上病例均经我院实验室病原学检查及血清学检查等临床实验确诊.结果:血清降钙素原和C反应蛋白与感染的严重程度相关,感染源及疾病程度不同时,血清降钙素原及C反应蛋白水平不同.细菌性感染组与正常对照组的降钙素原相比差异有统计学意义(P<0.05);细菌感染组与病毒感染组降钙素原相比较时,差异有统计学意义(P<0.05);病毒感染组与正常对照组降钙素原比较无统计学差异(P>0.05).三组之间的C反应蛋白相比,均有统计学差异(P<0.05).结论:利用血清降钙素原和C反应蛋白的检测对临床感染进行诊断,可以提高感染性疾病诊断的准确率,且可根据实验结果判断感染性疾病的严重程度,值得临床推广.%Objective:To investigate the serum procalcitonin (PCT) and C-reactive protein (CRP) in the diagnosis of infectious diseases.Method:A retrospective analysis was designed to explore the relationship of procalcitonin and C-reactive protein levels and Infectious disease.All the cases were confirmed by clinical trials of pathogenic examination in our hospital clinical laboratory.Result:The level of procalcitonin and C-reactive protein in serum is related to the severity of the infection disease.The concentration of procalcitonin between bacterial infection group and normal control group was different statistically significant (P <0.05) ; the concentration of procalcitonin in the bacterial infection group compared to the original with the viral infection group,the difference was statistically significant (P <0.05) ; the concentration of procalcitonin in the infection group and normal control group

  3. Research of the clinical application of serum procalcitonin test for sepsis%某市临床医生对降钙素原在脓毒症中临床应用的研究∗

    刘慧恒; 张民伟; 叶剑鸿; 李娟; 陈美君; 刘晓楣; 郭久冰

    2015-01-01

    Objective To evaluate the clinical application of serum procalcitonin test for diagnosis of sepsis in Xiamen,aimed at observing the application level for serum procalcitonin by different professional clinicians.Methods Retrospectively analyzed the data from 552 specimens collected at three integrated teaching hospitals in Xiamen from July 2012 to October 2013.Patients of sep-sis with positive culture blood were enrolled in the study.All specimens were divided into four groups according to specimen sources,including ICU group,non-ICU group,medicine systems group and surgery systems group.The blood submission rates for procalcitonin detection by different professional clinicians were compared.Results As compared with the non-ICU group,the ICU group had higher submission rate for procalcitonin detection(P < 0.05 ).Medicine systems group had higher submission rate for procalcitonin detection than surgery systems group(P <0.05).Conclusion There is significant difference between professional cli-nicians in procalcitonin application.Surgery clinicians are poor in accepting procalcitonin for diagnosis of sepsis in Xiamen.%目的:通过对552例次血培养阳性标本及病例资料的回顾性研究,观察不同专业临床医生对血样降钙素原(PCT)送检率的差异,评价不同专业临床医师对 PCT 临床应用的认知程度。方法选取厦门市3家教学医院,对2012年7月至2013年10月临床及血培养确诊为脓毒症的患者资料进行回顾性分析,按照血样科室来源分为重症监护室(ICU)组、非 ICU 组,内科组和外科组,比较不同组别间血样 PCT 送检率。结果ICU 组医师的血样 PCT 送检率明显高于非 ICU 组(P <0.05),内科组对脓毒症患者血样 PCT 的送检率明显高于外科组(P <0.05),但仍明显低于 ICU 组的血样 PCT 送检率(P <0.05)。结论厦门市不同专业临床医生在诊断脓毒症时的血样 PCT 送检率存在明显差别,ICU 医生送检率最高,其次是内

  4. Use of procalcitonin and C-reactive protein to evaluate vaccine efficacy against pneumonia.

    Shabir A Madhi

    2005-02-01

    Full Text Available BACKGROUND: Pneumonia remains the leading cause of death in young children. The poor specificity of chest radiographs (CXRs to diagnose pneumococcal pneumonia may underestimate the efficacy of pneumococcal conjugate vaccine in preventing pneumococcal pneumonia. METHODS AND FINDINGS: The efficacy of nine-valent pneumococcal conjugate vaccine among children not infected with HIV (21%; 95% confidence interval, 1%-37% increased when CXR-confirmed pneumonia was associated with serum C-reactive protein of 120 mg/l (12 mg/dl or more and procalcitonin of 5.0 ng/ml or more (64%; 95% confidence interval, 23%-83%. Similar results were observed in children infected with HIV. CONCLUSION: C-reactive protein and procalcitonin improve the specificity of CXR to diagnose pneumococcal pneumonia and may be useful for the future evaluation of the effectiveness of pneumococcal conjugate vaccine in preventing pneumococcal pneumonia.

  5. The effect of non-infectious diseases on serum procalcitonin concentrations in premature neonates%非感染因素对早产新生儿血清降钙素原浓度的影响

    吴志新; 郭婕; 许靖; 武荣; 花少栋; 封志纯

    2015-01-01

    Objective To study the effect of non-infectious factors on serum procalcitonin(PCT) in preterm neonates.MethodThe premature infants of neonatal intensive care unit(NICU) in our hospital were chosen from gestational age ranged from 33 to 36 weeks, birth time less than 12 hours without premature rupture and hospitalization period from January 2012 to December 2012. All of the premature infants were drawn blood immediately admitted to hospital and C-reactive protein (CRP), blood cultures and procalcitonin were tested. The types of premature infants non-infectious diseases included intracranial hemorrhage (ICH), neonatal respiratory distress syndrome (NRDS), neonatal asphyxia and the control group (preterm infants) without disease. The blood routine , C-reactive protein, blood culture, procalcitonin and other infections indicators in each group were monitored dynamicly in order to study the impact of these non-infectious diseases on serum procalcitonin concentrations by statistical analysis.Results ① Compared with the current literature recommended serum procalcitonin concentrations (<0.5ng / ml), procalcitonin concentrations in preterm neonates singniifcantly increase (1.07± 0.76) ng / ml.②Compared with control group (1.07±0.76) ng/ml,the procalcitonin levels in intracranial hemorrhage group (2.12± 0.99) ng/ml, neonatal respiratory distress syndrome group (2.28±1.09) ng/ml and asphyxia group (3.64± 3.17) ng / ml signiifcantly increased (F= 10.462,P <0.05).There were no signiifcant differences (F= 0.173,P= 0.950) among the different levels of intracranial hemorrhage group; Compared with the ifrst grade NRDS , the procalcitonin leves in second grade and third grade NRDS groups were significantly increased (F=5.475,P= 0.010); The procalciton level in severe asphyxia group was signiifcantly higher than in mild asphyxia group (t= 5.245,P= 0.003). Conclusions The procalcitonin concentration physiologically increased after preterm neonates were born. Many factors

  6. Diagnostic value of procalcitonin, CRP, leukocytes and BAL neutrophils for pulmonary complications in the immunocompromised host

    Daiana Stolz

    2006-12-01

    Full Text Available We evaluated the diagnostic accuracy of laboratory biomarkers and BAL differential cell count for the diagnosis of bacterial infection in severe immunosuppressed patients. One-hundred and seven consecutive patients undergoing bronchoscopy for suspected pulmonary infection were included in this study. Assessment included history, clinical examination, chest image studies, CRP, procalcitonin (ProCT, leukocyte counts, and BAL results. Patients were classified as having proven, possible, and non-bacterial infection.

  7. Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction

    Castelli, Gian Paolo; Pognani, Claudio; Meisner, Michael; Stuani, Antonio; Bellomi, Daniela; Sgarbi, Laura

    2004-01-01

    Introduction Both C-reactive protein (CRP) and procalcitonin (PCT) are accepted sepsis markers. However, there is still some debate concerning the correlation between their serum concentrations and sepsis severity. We hypothesised that PCT and CRP concentrations are different in patients with infection or with no infection at a similar severity of organ dysfunction or of systemic inflammatory response. Patients and methods One hundred and fifty adult intensive care unit patients were observed...

  8. Plasma Procalcitonin Concentration in Healthy Horses and Horses Affected by Systemic Inflammatory Response Syndrome

    Bonelli, F.; Meucci, V.; Divers, T.J.; Jose‐Cunilleras, E.; Corazza, M; Tognetti, R; Guidi, G.; Intorre, L.; Sgorbini, M.

    2015-01-01

    Background The diseases most frequent associated with SIRS in adult horses are those involving the gastrointestinal tract. An early diagnosis should be the goal in the management of horses with SIRS. Objective The objective of this study was to evaluate the plasma procalcitonin (PCT) concentration in healthy and SIRS horses to assess differences between the two groups. Animals Seventy‐eight horses (30 healthy and 48 SIRS). Methods Prospective in vivo multicentric study. Horses were classified...

  9. Procalcitonin as a biomarker of bacterial infection in pediatric patients after congenital heart surgery

    Chakravarti, Sujata B; Diane A Reformina; Lee, Timothy M; Malhotra, Sunil P; Mosca, Ralph S; Puneet Bhatla

    2016-01-01

    Background: Bacterial infection (BI) after congenital heart surgery (CHS) is associated with increased morbidity and is difficult to differentiate from systemic inflammatory response syndrome caused by cardiopulmonary bypass (CPB). Procalcitonin (PCT) has emerged as a reliable biomarker of BI in various populations. Aim: To determine the optimal PCT threshold to identify BI among children suspected of having infection following CPB. Setting and Design: Single-center retrospective observationa...

  10. Diagnostic value of lipopolysaccharide-binding protein and procalcitonin for sepsis diagnosis in forensic pathology

    Augsburger, Marc; Iglesias, Katia; Bardy, Daniel; Mangin, Patrice; Palmiere, Cristian

    2016-01-01

    The aims of this study were twofold. The first was to investigate the diagnostic performance of two biochemical markers, procalcitonin (PCT) and lipopolysaccharide-binding protein (LBP), considering each individually and then combined, for the postmortem diagnosis of sepsis. We also tested the usefulness of pericardial fluid for postmortem LBP determination. Two study groups were formed, a sepsis-related fatalities group of 12 cases and a control group of 30 cases. Postmortem native CT scans,...

  11. Is Procalcitonin a usefull biomarker for the risk stratification of facial cellulitis?

    Bertolus, Chloé; Schouman, Thomas; Aubry, Adeline; Hausfater, Pierre

    2016-01-01

    International audience Backgroundfacial cellulitis is an infectious disease that may require emergency surgical drainage based on clinical assessment. To date, no biological marker has been reported to be useful for risk stratification. Procalcitonin (PCT) is a diagnostic and prognostic sepsis biomarker. We aimed to study the usefulness of PCT dosage for the risk-stratification of facial cellulitis.Patients and methodsThis was a monocentric prospective study conducted in a referral center ...

  12. Prognostic value of procalcitonin in hospitalized patients with lower respiratory tract infections

    NOBRE Vandack; Borges, Isabela

    2016-01-01

    Lower respiratory tract infections are common and potentially lethal conditions and are a major cause of inadequate antibiotic prescriptions. Characterization of disease severity and prognostic prediction in affected patients can aid disease management and can increase accuracy in determining the need for and place of hospitalization. The inclusion of biomarkers, particularly procalcitonin, in the decision taken process is a promising strategy. This study aims to present a narrative review of...

  13. Hubungan Antara Neutrophil – Lymphocyte Count Ratio Dengan Kadar Procalcitonin Pada Pasien Sepsis

    Silalahi, Bratasena

    2016-01-01

    Background: Sepsis is a major worldwide problem which is associated with the high incidence of death annually. It takes rapid, and accurate diagnose to prevent death and worst outcomes of sepsis. The neutrophil-lymphocyte count ratio (NLCR) has been shown a simple promising method to predict sepsis. Purpose: To investigate the difference of NLCR value between sepsis patients and in infection non-sepsis patients and its relationship to procalcitonin Method : A cross sectional...

  14. Dual-Quantum-Dots-Labeled Lateral Flow Strip Rapidly Quantifies Procalcitonin and C-reactive Protein

    Qi, Xiaoping; Huang, YunYe; Lin, ZhongShi; Xu, Liang; Yu, Hao

    2016-01-01

    In the article, a dual-quantum-dots-labeled (dual-QDs-labeled) lateral flow strip (LFS) method was developed for the simultaneous and rapid quantitative detection of procalcitonin (PCT) and C-reactive protein (CRP) in the blood. Two QD-antibody conjugates with different fluorescence emission spectra were produced and sprayed on the LFS to capture PCT and CRP in the blood. Furthermore, a double antibody sandwich method for PCT and, meanwhile, a competitive inhibition method for CRP were employ...

  15. Prognostic Value of Procalcitonin in Adult Patients with Sepsis: A Systematic Review and Meta-Analysis.

    Dan Liu

    Full Text Available Procalcitonin (PCT has been widely investigated for its prognostic value in septic patients. However, studies have produced conflicting results. The purpose of the present meta-analysis is to explore the diagnostic accuracy of a single PCT concentration and PCT non-clearance in predicting all-cause sepsis mortality. We searched PubMed, Embase, Web of Knowledge and the Cochrane Library. Articles written in English were included. A 2 × 2 contingency table was constructed based on all-cause mortality and PCT level or PCT non-clearance in septic patients. Two authors independently evaluated study eligibility and extracted data. The diagnostic value of PCT in predicting prognosis was determined using a bivariate meta-analysis model. We used the Q-test and I2 index to test heterogeneity. Twenty-three studies with 3,994 patients were included. An elevated PCT level was associated with a higher risk of death. The pooled relative risk (RR was 2.60 (95% confidence interval (CI, 2.05-3.30 using a random-effects model (I(2 = 63.5%. The overall area under the summary receiver operator characteristic (SROC curve was 0.77 (95% CI, 0.73-0.80, with a sensitivity and specificity of 0.76 (95% CI, 0.67-0.82 and 0.64 (95% CI, 0.52-0.74, respectively. There was significant evidence of heterogeneity for the PCT testing time (P = 0.020. Initial PCT values were of limited prognostic value in patients with sepsis. PCT non-clearance was a prognostic factor of death in patients with sepsis. The pooled RR was 3.05 (95% CI, 2.35-3.95 using a fixed-effects model (I(2 = 37.9%. The overall area under the SROC curve was 0.79 (95% CI, 0.75-0.83, with a sensitivity and specificity of 0.72 (95% CI, 0.58-0.82 and 0.77 (95% CI, 0.55-0.90, respectively. Elevated PCT concentrations and PCT non-clearance are strongly associated with all-cause mortality in septic patients. Further studies are needed to define the optimal cut-off point and the optimal definition of PCT non-clearance for

  16. Serum procalcitonin elevation in critically ill patients at the onset of bacteremia caused by either gram negative or gram positive bacteria

    Prin Sébastien

    2008-03-01

    Full Text Available Abstract Background In the ICU, bacteremia is a life-threatening infection whose prognosis is highly dependent on early recognition and treatment with appropriate antibiotics. Procalcitonin levels have been shown to distinguish between bacteremia and noninfectious inflammatory states accurately and quickly in critically ill patients. However, we still do not know to what extent the magnitude of PCT elevation at the onset of bacteremia varies according to the Gram stain result. Methods Review of the medical records of every patient treated between May, 2004 and December, 2006 who had bacteremia caused by either Gram positive (GP or Gram negative (GN bacteria, and whose PCT dosage at the onset of infection was available. Results 97 episodes of either GN bacteremia (n = 52 or GP bacteremia (n = 45 were included. Procalcitonin levels were found to be markedly higher in patients with GN bacteremia than in those with GP bacteremia, whereas the SOFA score value in the two groups was similar. Moreover, in the study population, a high PCT value was found to be independently associated with GN bacteremia. A PCT level of 16.0 ng/mL yielded an 83.0% positive predictive value and a 74.0% negative predictive value for GN-related bacteremia in the study cohort (AUROCC = 0.79; 95% CI, 0.71–0.88. Conclusion In a critically ill patient with clinical sepsis, GN bacteremia could be associated with higher PCT values than those found in GP bacteremia, regardless of the severity of the disease.

  17. 血清降钙素原和C-反应蛋白在评价老年肺炎病情严重程度及预后中的价值探讨%Value of serum procalcitonin and c-reactive protein for elderly pneumonia severity and prognosis

    阿丽娅·艾依提; 白婷迪娜

    2013-01-01

    Objective To explore the value of serum procalcitonin and c-reactive protein for elderly pneumonia severity and prognosis. Methods 60 patients with community-acquired pneumonia treated in respiratory department clinics and wards were collected in our hospital from May 2010 to May 2012. Its severity divided into three group. 20 healthy cases were randomly selected from the same period in our hospital, as the control group. To compare serum procalcitonin and c -reactive protein of each groups. Results The serum procalcitonin and C -reactive protein of Group A, Group B, Group C was significantly higher than the control group and the group C serum procalcitonin and C-reactive protein levels was higher than group A, group B, the difference was statistically significant (P < 0.05). Conclusion Patients with pneumonia more severe the disease, the higher the concentration of serum procalcitonin and C-reactive protein. Detection of serum procalcitonin and c-reactive protein can contribute to the clinical judgment of severity of pneumonia.%目的 探讨血清降钙素原和C-反应蛋白在老年肺炎病情严重程度及预后的临床价值.方法 收集2010年5月~2012年5月在新疆维吾尔自治区人民医院接受治疗的社区获得性老年肺炎患者60例,按其严重程度分为A、B、C、三组.同时随机选取同一时期在新疆维吾尔自治区人民医院体检健康者20例作为对照组.比较各组患者血清血清降钙素原和C-反应蛋白水平的变化.结果 A、B、C组患者血清降钙素原水平和血清C-反应蛋白水平明显高于正常组,且C组血清降钙素原、C-反应蛋白水平均高于A、B组,比较差异均具有统计学意义(P < 0.05).结论 肺炎病情越重的患者,其血清降钙素原和C-反应蛋白浓度越高,检测血清降钙素原、C-反应蛋白可有助于临床判断肺炎的严重程度.

  18. Study on the Relationship Between Plasma Procalcitonin and Kawasaki Dis-ease Related with Bacterial Infection%血浆前降钙素与细菌性川崎病的关系研究

    徐小桥

    2014-01-01

    Objective To study the relationship between the level of plasma procalcitonin and kawasaki disease related with bacte-rial infection and its clinical value. Methods 86 cases of kawasaki disease diagnosed and treated in our hospital from June, 2011 to December, 2013 were selected as the object of the study by sampling and analyzed professionally and retrospectively. Results The plasma procalcitonin level of group with positive pathogens was significantly higher than that of group with negative pathogens. And plasma procalcitonin level of patients with bacterial infection was also significantly higher than that of patients with non-bac-terial infection, and the difference was statistically significant (P<0.05). Conclusion Plasma procalcitonin level is one of the main indicators for the diagnosis of kawasaki disease caused by bacterial infection or non-bacterial infection. It provides important refer-ence for the scientific diagnosis and treatment of the patients.%目的:研究血浆前降钙素水平与细菌感染相关川崎病的关系及临床价值。方法从该院2011年6月-2013年12月诊治的川崎病病例中,抽样选取86例作为该研究的对象,进行专业的回顾性分析。结果病原体阳性组的血浆前降钙素水平明显高于病原体阴性组,且细菌感染患者的血浆前降钙素水平也明显高于非细菌感染患者,差异有统计学意义(P<0.05)。结论血浆前降钙素水平是诊断细菌感染相关川崎病与非细菌感染相关川崎病的主要指标之一,为患者的科学诊治提供了重要的参考依据。

  19. 血液灌流对急性重度有机磷中毒的疗效观察%Values of serum procalcitonin in predicting severity and prognosis of community-acquired pneumonia in-patients

    朱小生; 方长太; 白兆青

    2011-01-01

    目的 探讨血液灌流对重度急性有机磷农药中毒(AOPP)的临床疗效,促进其推广及应用.方法 回顾性分析重症有机磷中毒患者的临床资料,将其分为血液灌流(HP)治疗组和对照组.所有病例均予以积极的内科治疗(洗胃、氯磷定、阿托品和机械通气等).对治疗组及对照组病人进行回顾性对照分析.结果 行HP组清醒时间,CHE活性恢复时间,住院时间均明显短于对照组,阿托品及氯磷定用药总量明显小于对照组,治愈率明显高于对照组.结论 HP能迅速清除体内毒物,明显缩短病程,提高重度AOPP抢救的成功率,应加强宣教及推广.%Aim To investigate the relationship of serum procalcitonin to severity and prognosis of community acquired pneumonia in-patients. Methods Retrospective analysis was made of community-acquired pneumonia in-patients admitted to hospital from July 2009 to July 2010. Results Among 324 cases of community-acquired pneumonia admitted,248 cases were included for analysis. The mean levels of serum procalcitonin,neutrophil number,average duration of intravenous antibiotic therapy, average hospital stay,PSI scale and CURB 65 score were(0.22±0.34) μg· L -1,(8.92±2.47)x109 ·L -1,(8.7 ±2.6)days,(9.2±2.4)days,67.8 ±33.5,2.12 ±0.45.The correlation indices of serum procalcitonin to PSI and CURB-65 score and duration of intravenous antibiotic therapy, average hospital stay were 0. 845,0.22,0. 404 and 0. 443,respectively. The mean procalcitonin levels of severe CAP and deaths were( 5.87 ± 2.83 ) μg · L -1 and( 2.42 ± 1.28 ) μg · L -1, respectively. The sensitivity and specificity of serum procalcitonin more than 0.5 μg · L -1 on admission were 0.714 and 0. 844 in predicting death. Conclusion The serum level of procalcitonin on admission is correlated with severity of community-acquired pneumonia in patients,and PCT≥0. 335 μg · L -1 may indicate poorer prognosis.

  20. The Comparison of Procalcitonin Guidance Administer Antibiotics with Empiric Antibiotic Therapy in Critically Ill Patients Admitted in Intensive Care Unit

    Atabak Najafi

    2015-10-01

    Full Text Available The empiric antibiotic therapy can result in antibiotic overuse, development of bacterial resistance and increasing costs in critically ill patients. The aim of the present study was to evaluate the effect of procalcitonin (PCT guide treatment on antibiotic use and clinical outcomes of patients admitted to intensive care unit (ICU with systemic inflammatory response syndrome (SIRS.  A total of 60 patients were enrolled in this study and randomly divided into two groups, cases that underwent antibiotic treatment based on serum level of PCT as PCT group (n=30 and patients who undergoing antibiotic empiric therapy as control group (n=30. Our primary endpoint was the use of antibiotic treatment. Additional endpoints were changed in clinical status and early mortality. Antibiotics use was lower in PCT group compared to control group (P=0.03. Current data showed that difference in SOFA score from the first day to the second day after admitting patients in ICU did not significantly differ (P=0.88. Patients in PCT group had a significantly shorter median ICU stay, four days versus six days (P=0.01. However, hospital stay was not statistically significant different between two groups, 20 days versus 22 days (P=0.23.  Early mortality was similar between two groups. PCT guidance administers antibiotics reduce antibiotics exposure and length of ICU stay, and we found no differences in clinical outcomes and early mortality rates between the two studied groups.

  1. Procalcitonin and C-reactive protein-based decision tree model for distinguishing PFAPA flares from acute infections

    Kraszewska-Głomba, Barbara; Szymańska-Toczek, Zofia; Szenborn, Leszek

    2016-01-01

    As no specific laboratory test has been identified, PFAPA (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) remains a diagnosis of exclusion. We searched for a practical use of procalcitonin (PCT) and C-reactive protein (CRP) in distinguishing PFAPA attacks from acute bacterial and viral infections. Levels of PCT and CRP were measured in 38 patients with PFAPA and 81 children diagnosed with an acute bacterial (n=42) or viral (n=39) infection. Statistical analysis with the use of the C4.5 algorithm resulted in the following decision tree: viral infection if CRP≤19.1 mg/L; otherwise for cases with CRP>19.1 mg/L: bacterial infection if PCT>0.65ng/mL, PFAPA if PCT≤0.65 ng/mL. The model was tested using a 10-fold cross validation and in an independent test cohort (n=30), the rule’s overall accuracy was 76.4% and 90% respectively. Although limited by a small sample size, the obtained decision tree might present a potential diagnostic tool for distinguishing PFAPA flares from acute infections when interpreted cautiously and with reference to the clinical context. PMID:27131024

  2. Procalcitonin and C-reactive protein-based decision tree model for distinguishing PFAPA flares from acute infections.

    Kraszewska-Głomba, Barbara; Szymańska-Toczek, Zofia; Szenborn, Leszek

    2016-01-01

    As no specific laboratory test has been identified, PFAPA (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) remains a diagnosis of exclusion. We searched for a practical use of procalcitonin (PCT) and C-reactive protein (CRP) in distinguishing PFAPA attacks from acute bacterial and viral infections. Levels of PCT and CRP were measured in 38 patients with PFAPA and 81 children diagnosed with an acute bacterial (n=42) or viral (n=39) infection. Statistical analysis with the use of the C4.5 algorithm resulted in the following decision tree: viral infection if CRP≤19.1 mg/L; otherwise for cases with CRP>19.1 mg/L: bacterial infection if PCT>0.65ng/mL, PFAPA if PCT≤0.65 ng/mL. The model was tested using a 10-fold cross validation and in an independent test cohort (n=30), the rule's overall accuracy was 76.4% and 90% respectively. Although limited by a small sample size, the obtained decision tree might present a potential diagnostic tool for distinguishing PFAPA flares from acute infections when interpreted cautiously and with reference to the clinical context. PMID:27131024

  3. Procalcitonin: Is it a predictor of noninvasive positive pressure ventilation necessity in acute chronic obstructive pulmonary disease exacerbation?

    Ahmet Cemal Pazarli

    2012-01-01

    Full Text Available Background: Acute exacerbations of chronic obstructive pulmonary disease (AeCOPD are important causes of morbidity and mortality. In this study, we analyzed procalcitonin (PCT levels in AeCOPD and stable period of COPD in order to evaluate usage of PCT in the prediction of the severity of AeCOPD, and its value on the planing of noninvasive positive pressure ventilation (NPPV. Materials and Methods: In this cross sectional study (2009-2010 118 COPD patients were enrolled, 68 of them (58% were in acute exacerbations (case group. The others had stabile COPD and they were defined as control group. Results: In case group the mean levels of PCT (0.19 ± 0.02 C-Reactive Protein (44.7 ± 5.92, erythrocyte sedimentation rate (28.4 ± 2.65, white blood cell (9.4 ± 0.43 and %neutrophils (69.9 ± 1.22 were significantly higher than controls (P = 0.0001. There was no difference between PCT levels based on stages of COPD. There were significiant differences in mean PCT levels according to type and severity of AeCOPD. Mean PCT level in hospitalized patients receiving NPPV was 0.36 ng/ml, while it was 0.15 ng/ml for those treated without NPPV (P = 0.0001. PCT cut-off value for NPPV indication was determined to be 0.10 ng/ml. Conclusions: PCT levels were found to be higher in AeCOPD patients than in stable COPD patients, as expected. Also mean PCT levels increased especially in cases with severe AeCOPD and those receiving NPPV among them. In the present study, we determined a cut off value of PCT as 0.10 ng/ml as a predictor of necessity of NPPV in AeCOPD.

  4. Prediction of high-grade vesicoureteral reflux after pediatric urinary tract infection: external validation study of procalcitonin-based decision rule.

    Sandrine Leroy

    Full Text Available BACKGROUND: Predicting vesico-ureteral reflux (VUR ≥3 at the time of the first urinary tract infection (UTI would make it possible to restrict cystography to high-risk children. We previously derived the following clinical decision rule for that purpose: cystography should be performed in cases with ureteral dilation and a serum procalcitonin level ≥0.17 ng/mL, or without ureteral dilatation when the serum procalcitonin level ≥0.63 ng/mL. The rule yielded a 86% sensitivity with a 46% specificity. We aimed to test its reproducibility. STUDY DESIGN: A secondary analysis of prospective series of children with a first UTI. The rule was applied, and predictive ability was calculated. RESULTS: The study included 413 patients (157 boys, VUR ≥3 in 11% from eight centers in five countries. The rule offered a 46% specificity (95% CI, 41-52, not different from the one in the derivation study. However, the sensitivity significantly decreased to 64% (95%CI, 50-76, leading to a difference of 20% (95%CI, 17-36. In all, 16 (34% patients among the 47 with VUR ≥3 were misdiagnosed by the rule. This lack of reproducibility might result primarily from a difference between derivation and validation populations regarding inflammatory parameters (CRP, PCT; the validation set samples may have been collected earlier than for the derivation one. CONCLUSIONS: The rule built to predict VUR ≥3 had a stable specificity (ie. 46%, but a decreased sensitivity (ie. 64% because of the time variability of PCT measurement. Some refinement may be warranted.

  5. Diagnostic Value of Serum Procalcitonin in Children Respiratory Tract Infection%儿童呼吸道医院感染诊断中血清降钙素原检测的价值观察

    杨丽; 赵东赤

    2016-01-01

    Objective To evaluate the diagnostic value of serum procalcitonin in children respiratory tract infection.Methods In 50 cases between January 1, 2015 to January 1,2016 in my hospital for treatment of respiratory tract infection in children hospital as the research object(observation group)to the same period in the hospital healthy 50 healthy children as a reference object(control group),serum procalcitonin levels two children.Results The survey results showed that serum procalcitonin levels in the observation group is significantly higher,the diference was statisticaly significant(P<0.05).ConclusionThe diagnosis of nosocomial infection in children with respiratory tract can be measured when serum procalcitonin levels the most important basis for the determination.%目的:探讨血清降钙素原检测对儿童呼吸道医院感染的诊断价值。方法以2015年1月1日~2016年1月1日在我院诊治的呼吸道医院感染患儿50例为研究对象(观察组),以同期在医院健康体检的50例健康儿童为参照对象(对照组),检测两组儿童的血清降钙素原水平。结果调查结果显示,在血清降钙素原水平上观察组高于对照组,差异具有统计学意义(P<0.05)。结论在诊断儿童呼吸道医院感染的时候可以将测得的血清降钙素原水平最为重要的判定依据。

  6. Significance of serum procalcitonin and blood gas analysis in the risk anticipation of patients with acute exacerbation of COPD%血清降钙素原联合血气分析检测对AECOPD患者临床风险预测的意义

    曹友红

    2013-01-01

    Objective To estimate the prognostic value of serum procalcitonin and blood gas analysis in the risk anticipation of patients with acute exacerbation of chronic obstructive pulmonary disease ( AECOPD ). Methods The study selected 65 patients with AECOPD as the test group and 50 healthy people as the control group. Their PCT level and arterial blood gas analysis indexes were tested and dynamically monitored 5 days after the treatment. Results Serum procalcitonin and blood gas analysis had a high sensitivity, and the differences showed a statistical significance before and after the treatment (P 0.05).结论 联合检测血清降钙素原及血气分析对AECOPD患者的风险预测具有较重要的临床意义.

  7. Value research of procalcitonin in the identification between bacterial pneumonia and pulmonary tuberculosis%降钙素原在细菌性肺炎及肺结核中的鉴别研究

    尹义平; 胡苏萍; 杨澄清; 李雪英

    2013-01-01

    目的 通过测定细菌性肺炎及肺结核患者血清降钙素原水平进一步探讨降钙素原对这两种疾病的鉴别诊断价值.方法 收集细菌性肺炎患者(20例)及肺结核患者(21例)血清标本,两组患者病情严重程度达到系统性炎症反应综合征(SIRS)水平,采用免疫荧光法分别检测两组患者血清降钙素原水平,并进行比较,绘制ROC曲线,根据曲线下面积评价降钙素原对上述两种疾病的鉴别诊断价值.结果 细菌性肺炎患者血清降钙素原水平明显高于肺结核患者(P<0.05),绘制ROC曲线后,曲线下面积(AUC)为0.923,95%可信区间为(0.844,1.000),在临界值为0.20 ng/ml时,其灵敏度为85%,特异度为86%.结论 降钙素原在临界值为0.20 ng/ml时,对达到SIRS水平的细菌性肺炎及肺结核患者具有良好的鉴别诊断价值.%Objective To explore the differential value of procalcitonin between bacterial pneumonia and pulmonary tuberculosis. Methods The serum procalcitonin of patients with bacterial pneumonia ( 20 cases ) and pulmonary tuberculosis (21 cases ) was detected by immunofluorescence and then compared. All patients were suffering from systemic inflammatory response syndrome ( SIRS ). HOC curves were described and the differential value of procalcitonin was evaluated according to AUG. Results The level of serum procalcitonin was significantly higher in patients with bacterial pneumonia than in patients with pulmonary tuberculosis ( P < 0. 05 ). The AUC of ROC curve was 0.923, 95% Cl ( 0. 844, 1.000 ). At the cut-off value of 0.20 ng/ml, the sensitivity was 85% , and the specificity was 86 % . Conclusion When the level of procalcitonin reaches the cut-off value of 0. 20 ng/ml, procalcitonin can be used as a valuable clinical inflammatory marker to differentiate bacterial pneumonia and pulmonary tuberculosis with SIRS.

  8. 血清降钙素原和内毒素在肝硬化患者腹水感染中的诊断价值%The values of serum procalcitonin and endotoxin in diagnosis of the ascitic infection in patients with cirrhosis

    党燕; 于艳华; 刘新; 张立丽; 陈铭; 娄金丽

    2014-01-01

    Objective To investigate the clinical value of serum procalcitonin and endotoxin in diagnosis of the ascitic infection in patients with liver cirrhosis .Methods Retrospective study on 61 cirrhotic patients with ascitic infection and 67 cirrhotic patients with sterile ascites in Beijing Youan Hospital from August 2012 to December 2013 .The levels of procalcitonin and endotoxin in serum of these patients were analyzed .Results The common pathogens were Enterococcus faecium, Staphylococcus haemolyticus, Escherichia coli, Staphylococcus epidermidis and so on.Mean values of procalcitonin and endotoxin in the ascitic infection group were significantly higher than those in the non-ascitic infection group(P<0.01).ROC curve analysis showed that the areas under the curve of procalcitonin and endotoxin were 0.983 and 0.919, respectively.The sensitivities of procalcitonin and endotoxin were 93.5% and 83.6% respectively, while the specificities were 88.1% and 97.0% respectively in diagnosis of the ascitic infection .Conclusion The serum levels of procalcitonin and endotoxin in cirrhotic patients with ascitic infection both rose and had high sensitivities and specificities .Detections of procalcitonin and endotoxin could be applied in diagnosis of ascitic infection in patients with cirrhosis as fast and accurate auxiliary indicators.The value of procalcitonin was higher especially .%目的:探讨血清降钙素原和内毒素浓度在肝硬化患者腹水感染诊断中的应用价值。方法回顾性研究首都医科大学附属北京佑安医院2012年8月至2013年12月的61例肝硬化腹水感染患者和67例肝硬化腹水无感染患者的血清降钙素原和内毒素的质量浓度并进行统计分析。结果腹水培养阳性的病原菌最常见的依次为屎肠球菌、溶血葡萄球菌、大肠埃希菌、表皮葡萄球菌等。与非腹水感染组相比,腹水感染组的血清降钙素原、内毒素检测结果均显著升高,差

  9. Research of Procalcitonin in Early Diagnosis of Infection in Breast Cancer Patients with Neutropenia after Chemotherapy%降钙素原早期诊断乳腺癌化疗后粒细胞减少伴感染的研究

    郭满; 张浩; 李伟汉; 刘平贤; 杜新峰; 翟晓健

    2014-01-01

    目的:探讨降钙素原在乳腺癌化疗后粒细胞减少伴发热患者中的临床应用价值。方法:回顾性分析2008年3月-2012年9月本院收治的118例乳腺癌化疗后中性粒细胞减少伴发热患者临床资料,根据患者临床症状、体征、病原及影像学资料,将患者分为感染组和发热原因不详组,分析两组血清降钙素原水平差异及血清降钙素原水平与患者年龄、化疗方案、发热程度和粒细胞缺乏的关系。结果:感染组血清降钙素原水平明显高于发热原因不详组(P0.05)。结论:血清降钙素原水平对于乳腺癌化疗后中性粒细胞减少伴感染的早期诊断具有重要意义,且不受患者的年龄、化疗方案、发热程度和粒细胞水平影响。%Objective:To explore clinical value of procalcitonin in breast cancer patients with neutropenia associated with fever after chemotherapy. Method:The clinical data of 118 hospitalized patients with breast cancer associated with fever after chemotherapy from March 2008 to September 2012 were analyzed. The patients were divided into the infected group and the fever reasons unknown group according to clinical symptoms,signs,etiology. The relationship of serum procalcitonin levels were comparative analyzed between the two groups. The relationship of serum procalcitonin levels with age,chemotherapy scheme,heating degree and agranulocytosis levels were analyzed. Result:Serum procalcitonin levels in the infected group was significantly higher than the fever reasons unknown group(P0.05). Conclusion:Serum procalcitonin levels has a great significance for early diagnosis of infection in breast cancer patients with neutropenia associated with fever after chemotherapy,and it did not infected by patients age,chemotherapy scheme, heating degree and agranulocytosis levels.

  10. Taux de la procalcitonine durant la grossesse, l'accouchement et le post-partum

    Paccolat, Céline

    2013-01-01

    Les complications infectieuses durant la grossesse constituent le problème médical le plus fréquemment rencontré chez la femme enceinte. Il est actuellement bien démontré que les marqueurs couramment utilisés dans le diagnostic des infections, tels que la leucocytose et la protéine C réactive (CRP), doivent être utilisés prudemment durant la grossesse, en raison de la modification physiologique de leurs valeurs de normalité durant cette période. La procalcitonine (PCT) est, depuis plusieurs a...

  11. Procalcitonin as diagnostic marker of infection in solid tumors patients with fever

    Vincenzi, B; I. Fioroni; Pantano, F; Angeletti, S; G. Dicuonzo; Zoccoli, A.; Santini, D; Tonini, G

    2016-01-01

    In oncologic patients fever is a non-specific clinical marker of different clinical settings. Procalcitonin (PCT) seems to be the most promising infection marker. We aimed to define the potential role of PCT as an earlier diagnostic marker in patients with fever and solid tumor. This retrospective study enrolled 431 patients. All of them performed hemoculture (HE) and basal PCT assessment (reference laboratory cut-off: ≤0.5 or >0.5 ng/dL) before starting antibiotic therapy. Gram positive (G+)...

  12. 降钙素原在实体肿瘤化疗后粒细胞减少伴发热患者中的应用%Application of procalcitonin in solid tumors patients with neutropenia associated with fever after chemotherapy

    胡佳文; 吴先正; 吴志雄

    2013-01-01

    目的 探讨降钙素原在实体肿瘤化疗后粒细胞减少伴发热患者中的临床应用.方法 回顾性分析收治的90例实体瘤伴发热住院患者的临床资料,根据患者的临床症状及体征、病原学和影像学资料,将90例患者分为感染组和发热原因不详组,对比分析两组患者的血清降钙素原水平,以及血清降钙素原水平与患者年龄、性别、发热程度和粒细胞水平之间的关系.结果 实体肿瘤化疗后伴发热的患者中,感染组患者血清降钙素原水平明显高于发热原因不详组(P<0.05);血清降钙素原水平在感染组中不同年龄、性别及粒细胞水平间比较,差异均无统计学意义(x2=1.616、1.099、6.840,P=0.806、0.577、0.145);降钙素原水平在不同发热程度患者间比较,差异无统计学意义(x2=1.229,P=0.219).结论 在实体瘤化疗后发热的患者中,血清降钙素原水平对于感染的诊断具有重要意义,不受患者的年龄、性别、发热程度和粒细胞水平影响.%Objective To investigate the clinical application of procalcitonin in solid tumors patients with neutropenia associated with fever after chemotherapy.Methods The clinical data of 90 cases of hospitalized patients with solid tumors associated with fever were analyzed retrospectively.90 cases of hospitalized patients were divided into infected group and fever reasons unknown group accorded to clinical symptoms,signs,etiology and imaging.The relationship of serum procalcitonin levels were comparative analyzed between the two groups.The relationship of serum procalcitonin levels with age,gender,heating degree and granulocyte levels were analyzed.Results Serum procalcitonin levels of solid tumors associated with fever patients in the infected group were significantly higher fever reasons unknown group (P < 0.05) ; Serum procalcitonin levels in different age,gender,and granulocyte levels in the infected group were compared,the difference was not

  13. Urine - abnormal color

    ... medlineplus.gov/ency/article/003139.htm Urine - abnormal color To use the sharing features on this page, please enable JavaScript. The usual color of urine is straw-yellow. Abnormally colored urine ...

  14. The clinical application of procalcitonin, leukocyte count and C-reactive protein in elderly patients with infection

    吴培

    2012-01-01

    Objective To analyze and compare the clinical application values of procalcitonin(PCT) ,leukocyte count (WBC) and C-reactive protein(CRP) in elder patients with infection. Methods In patients(age≥65 yrs,axillary temperature>38.0℃) with infection or suspected infection

  15. Clinical and Cost-Effectiveness of Procalcitonin Test for Prodromal Meningococcal Disease-A Meta-Analysis.

    Jennifer M Bell

    Full Text Available Despite vaccines and improved medical intensive care, clinicians must continue to be vigilant of possible Meningococcal Disease in children. The objective was to establish if the procalcitonin test was a cost-effective adjunct for prodromal Meningococcal Disease in children presenting at emergency department with fever without source.Data to evaluate procalcitonin, C-reactive protein and white cell count tests as indicators of Meningococcal Disease were collected from six independent studies identified through a systematic literature search, applying PRISMA guidelines. The data included 881 children with fever without source in developed countries.The optimal cut-off value for the procalcitonin, C-reactive protein and white cell count tests, each as an indicator of Meningococcal Disease, was determined. Summary Receiver Operator Curve analysis determined the overall diagnostic performance of each test with 95% confidence intervals. A decision analytic model was designed to reflect realistic clinical pathways for a child presenting with fever without source by comparing two diagnostic strategies: standard testing using combined C-reactive protein and white cell count tests compared to standard testing plus procalcitonin test. The costs of each of the four diagnosis groups (true positive, false negative, true negative and false positive were assessed from a National Health Service payer perspective. The procalcitonin test was more accurate (sensitivity=0.89, 95%CI=0.76-0.96; specificity=0.74, 95%CI=0.4-0.92 for early Meningococcal Disease compared to standard testing alone (sensitivity=0.47, 95%CI=0.32-0.62; specificity=0.8, 95% CI=0.64-0.9. Decision analytic model outcomes indicated that the incremental cost effectiveness ratio for the base case was £-8,137.25 (US $ -13,371.94 per correctly treated patient.Procalcitonin plus standard recommended tests, improved the discriminatory ability for fatal Meningococcal Disease and was more cost

  16. Role of Maternal Serum Procalcitonin, Interleukin-6 and hs-C Reactive Protein in Prediciton of Subclinical (Intrauterine) Infection in Preterm Premature Rupture of Membranes

    Amany M.E. Abd Elmegeed*, Sabah I. Abd Elreheem*, Al-Shimaa Allam Abd

    2011-01-01

    To evaluate the role of procalcitonin (PCT), high senstive C-reactive protein (hs-CRP) and Interleukin-6 (IL-6) for prediction of subclinical intrauterine infection in pregnant women with preterm premature rupture of membranes. Methods: Twenty patients with preterm premature rupture of membranes PPROM (study group) and twenty apparently healthy pregnant women (control) group between 26-34 weeks of pregnancy were enrolled in this study. In all cases analysis of serum procalcitonin by high perf...

  17. Comparison of diagnostic and prognostic utility of lactate and procalcitonin for sepsis in adult cancer patients presenting to emergency department with systemic inflammatory response syndrome

    Keçe, Esra; YAKA, Elif; Yılmaz, Serkan; Doğan, Nurettin Özgür; Alyeşil, Cansu; Pekdemir, Murat

    2016-01-01

    Objectives Differentiating sepsis from other noninfectious causes of systemic inflammatory response syndrome (SIRS) in cancer patients is often challenging. Although lactate and procalcitonin have been studied extensively regarding sepsis management, little is known about their utility in cancer patients. This study aimed to compare the diagnostic and prognostic utility of lactate and procalcitonin for sepsis in cancer patients. Material and methods This prospective case-control study was con...

  18. Relationship between procalcitonin and pathogen%降钙素原与细菌性肺炎致病原的临床价值探讨

    左震华; 管希周

    2015-01-01

    Objective To discuss the role of procalcitonin (PCT)in the identification of gram negative bacteria and gram positive bacteria in bacteria infection pulmonary disease.Methods 186 patients with pulmonary infection (including community acquired pneumonia and hospital acquired pneumonia) from January 201 1 to May 2012 in the people′s liberation army general hospital were retrospectively analyzed.They were divided into gram negative bacteria group (n =95)and gram positive bacteria group (n =91).The level of serum procalcitonin was detected,the bacteria identification condition of PCT was analyzes by the receiver operating characteristic curve.Results The level of PCT in gram positive bacteria group was markedly higher than that in gram negative bacteria group (t =1 1.09,P <0.05).When the level of PCT was 3.8 μg/L,the diagnostic sensitivity and specificity of gram positive bacterial infection were 80% and 71%,respectively.Conclusions In the bacterial infection lung diseases,PCT in gram positive bacteria infection is significantly increased compared with gram negative bacteria infection.The preliminary judgment on the bacterial category can be made through the level of PCT.%目的:降钙素原(procalcitonin,PCT)用于细菌感染性肺部疾病中革兰阴性菌及革兰阳性菌的鉴定分析的初步探讨。方法对解放军总医院呼吸科2011年1月至2012年5月收住的186例中重症肺炎患者(包括社区获得性肺炎和医院获得性肺炎)进行回顾性分析,分为革兰阴性杆菌组(n =95)和革兰阳性球菌组(n =91),了解血清 PCT 等指标变化情况,采用受试者工作特征曲线比较 PCT 对于2种菌鉴别情况。结果研究病例中,革兰阳性球菌组 PCT 水平较革兰阴性杆菌组高(t =11.09,P <0.05)。PCT 在3.78μg/L 时,预测革兰阳性球菌感染的敏感性为80%,特异性为71%。结论在细菌感染性肺部疾病中,PCT 水平在革兰阳性菌感染时较革兰阴性菌高,通过 PCT 的数值水平

  19. THE VALUE OF PROCALCITONIN MEASUREMENT IN MENINGITIS PATIENTS

    SHAIMAA A. HAMEED

    2015-04-01

    Full Text Available Background: Meningitis is defined as inflammation of the membranes that surround the brain and spinal cord and can occur at any age, it is caused by infectious microorganisms include (bacteria, viruses, fungi, and parasites and non infectious include (drugs, carcinoma and inflammatory disorder. Objective: The objective of the present study was to evaluate the value of PCT levels to discriminate between bacterial and non-bacterial meningitis patients. Methods: A total of 40 patients with meningitis admitted to emergency department of Baghdad teaching hospital and pediatrics emergency room in child welfare teaching hospital were followed in this prospective study. Cerebrospinal fluid (CSF sample where collected from 40 patients and serum sample collected from these patients and healthy person. NHS real-time PCR technique using to identified the type of bacteria and serum levels of PCT were measured. Results: The diagnosis of meningitis was based on clinical findings, gram staining, culture, and chemical analysis of CSF. Twenty-eight of patients were diagnosed as bacterial meningitis and the other twelve patients as non-bacterial meningitis. The mean PCT level in patients with bacterial meningitis was 658.00 pg/ml, and the lower level was 21. Pg/ml, while the higher level in patients with non-bacterial meningitis was 11.00 pg/ml (mean level, 5.30 pg/ml. It is clear from the range of serum PCT level that there are no overlapping values seen for serum PCT in both groups. Conclusion: Serum PCT levels can be used in the early diagnosis of bacterial meningitis and is more valuable marker than the other predictive marker. Similarly, they may be useful in differential diagnosis of bacterial and non-bacterial meningitis to assess treatment efficacy.

  20. In Critically Ill Patients, Serum Procalcitonin Is More Useful in Differentiating between Sepsis and SIRS than CRP, Il-6, or LBP

    Iwan A. Meynaar

    2011-01-01

    Full Text Available We studied the usefulness of serum procalcitonin (PCT, interleukin-6 (IL-6, lipopolysaccharide binding protein (LBP levels and C-reactive protein (CRP levels, in differentiating between systemic inflammatory response syndrome (SIRS and sepsis in critically ill patients. Methods. In this single centre prospective observational study we included all consecutive patients admitted with SIRS or sepsis to the ICU. Blood samples for measuring CRP, PCT, IL-6 and LBP were taken every day until ICU discharge. Results. A total of 76 patients were included, 32 with sepsis and 44 with SIRS. Patients with sepsis were sicker on admission and had a higher mortality. CRP, PCT, IL-6 and LBP levels were significantly higher in patients with sepsis as compared to SIRS. With PCT levels in the first 24 hours after ICU admission 10 ng/mL, sepsis with bacterial infection was very likely (positive predictive value 88%. PCT was best at discriminating between SIRS and sepsis with the highest area under the ROC curve (0.95, 95% CI 0.90–0.99. Discussion. This study showed that PCT is more useful than LBP, CRP and IL-6 in differentiating sepsis from SIRS.

  1. Level of urinary liver-type fatty acid-binding protein is associated with cardiac markers and electrocardiographic abnormalities in type-2 diabetes with chronic kidney disease stage G1 and G2.

    Maeda, Yoshiteru; Suzuki, Atsushi; Ishii, Junnichi; Sekiguchi-Ueda, Sahoko; Shibata, Megumi; Yoshino, Yasumasa; Asano, Shogo; Hayakawa, Nobuki; Nakamura, Kazuhiro; Akiyama, Yasukazu; Kitagawa, Fumihiko; Sakuishi, Toshiaki; Fujita, Takashi; Hashimoto, Shuji; Ozaki, Yukio; Itoh, Mitsuyasu

    2015-05-01

    Urinary liver-type fatty acid-binding protein (L-FABP) reflects the degree of stress in proximal tubules of the kidney. We examined the level of L-FABP in type-2 diabetes mellitus (T2DM) patients with chronic kidney disease (CKD) stage G1 and G2, and its relationship with cardiac markers and electrocardiographic (ECG) abnormalities. T2DM patients whose estimated glomerular filtration rate (eGFR) was ≥60 mL/min/1.73 m(2) were recruited [n = 276 (165 males), mean age 64 years]. The median level of urinary L-FABP was 6.6 μg/gCr. Urinary L-FABP showed significant correlation with urinary albumin-to-creatinine ratio (ACR) (r = 0.51, p L-FABP ≤8.4 μg/gCr and ACR ≤30 mg/gCr; group 2, L-FABP ≤8.4 μg/gCr and ACR >30 mg/gCr; group 3, L-FABP >8.4 μg/gCr and ACR ≤30 mg/gCr; group 4, L-FABP >8.4 μg/gCr and ACR >30 mg/gCr). Compared with group 1, group 4 was significantly higher in systolic blood pressure, and eGFR using standardized serum cystatin C, high-sensitivity troponin T, and N-terminal pro-brain natriuretic peptide (NT-proBNP). Group 4 had significantly higher level of NT-proBNP than group 3. Groups 2, 3 and 4 showed more ECG abnormalities than group 1. These findings suggest that simultaneous measurement of urinary L-FABP and ACR should be useful to assess cardiovascular damage reflecting on the elevation of cardiac markers and ECG abnormalities in T2DM with CKD G1 and G2. PMID:24626813

  2. 广东省成年体检人群异常血脂水平分布情况调查%Investigation of the distribution of abnormal blood lipid levels of health examination adults of all ages in Gangdong

    李华; 魏莲; 陈佑明; 黄敬; 刘铁连; 刘京平

    2013-01-01

    OBJECTIVE To investigate the distribution of abnormal blood lipid levels of health examination adults in Guangdong Province. METHODS We investigated and statistically analyzed abnormal blood lipid levels of 28 447 people the age of 20 years and over during period of November 2009 and November 2010 in Guangdong Province. Investigated health examination adult at different ages and gender, and abnormal blood lipid composition. According to abnormal blood lipid sample, there were three groups including only high total cholesterols (group A) ; only high triglycerides (group B) ; both high total cholesterol and triglyceride (group C). RESULTS There were significantly age differences in the proportion of abnormal blood lipid levels in the other age groups (P = 0.000) , except the abnormal blood lipid level of age group of 50- years without gender differences ; And there were significant gender differences (P ≤ 0.05) in the composition of lipid abnormalities of male and female in other ages' groups, including in group A and group B, group A and group C group B and group C, except in 20- and over 40- age groups between group B and C; And there were significant differences {P - 0.000) of the composition of lipid abnormalities on genders between three groups; also there was a different distribution of abnormal blood lipid composition of men and women of all ages. CONCLUSION There are significantly differences on the composition of lipid abnormalities, ages and genders of Guangdong adult medical health examination groups of all ages, also there are significant differences in the incidence rate of abnormal blood lipid and proportion of mixed one of female in the 50-year-old, which is highly above male with the same age, and also highly above other ages female, suggesting that postmenopausal female should pay attention to regular blood checks, for which helps prevent and reduce the incidence of cardiovascular disease.%目的 调查广东省成年体检人群各年龄段男女

  3. Urine - abnormal color

    The usual color of urine is straw-yellow. Abnormally colored urine may be cloudy, dark, or blood-colored. ... Abnormal urine color may be caused by infection, disease, medicines, or food you eat. Cloudy or milky urine is a sign ...

  4. Serum Levels of Tissue Inhibitors of Metalloproteinase 2 in Patients With Systemic Sclerosis With Duration More Than 2 Years: Correlation With Cardiac and Pulmonary Abnormalities

    Amira Shahin

    2006-01-01

    with elevated TIMP-2 levels was significantly higher than dSSc patients with normal levels (P=.013. Four patients out of five with elevated TIMP-2 levels showed diastolic dysfunction (80%, compared to 2 out of 15 lSSc patients with normal levels (13.3%, with P=.014. Our research, though involving a small group of patients, points to the probable role of TIMP-2 in the development of pulmonary lesions in dSSc patients and cardiac lesions in lSSc patients with duration equal to or more than 2 years.

  5. Procalcitonin and procalcitonin kinetics for diagnosis and prognosis of intravascular catheter-related bloodstream infections in selected critically ill patients: a prospective observational study

    Theodorou Vasiliki P

    2012-10-01

    Full Text Available Abstract Background Procalcitonin (PCT has emerged as a valuable marker of sepsis. The potential role of PCT in diagnosis and therapy monitoring of intravascular catheter-related bloodstream infections (CRBSI in intensive care unit (ICU is still unclear and was evaluated. Methods Forty-six patients were included in the study, provided they were free of infection upon admission and presented the first episode of suspected CRBSI during their ICU stay. Patients who had developed any other infection were excluded. PCT was measured daily during the ICU hospitalization. Primary endpoint was proven CRBSI. Therapy monitoring as according to infection control was also evaluated. Results Among the 46 patients, 26 were diagnosed with CRBSI. Median PCT on the day of infection suspicion (D0 was 7.70 and 0.10 ng/ml for patients with and without proven CRBSI, respectively (p 0.20 ng/ml of PCT between the D0 and any of the 4 preceding days was associated with a positive predictive value exceeding 96%. PCT concentrations from the D2 to D6 after suspected infection tended to decrease in controlled patients, whereas remained stable in non-controlled subjects. A PCT concentration exceeding 1.5 ng/ml during D3 was associated with lack of responsiveness to therapy (p = 0.028. Conclusions We suggest that PCT could be a helpful diagnostic and prognostic marker of CRBSI in critically ill patients. Both absolute values and variations should be considered.

  6. Procalcitonin as a marker for the diagnosis of sepsis

    C. G. Chivate

    2016-04-01

    Results: PCT proved to be an excellent indicator of sepsis. Serum PCT levels predicts mortality in the present study. Conclusions: PCT is among the most promising sepsis markers capable of completing clinical signs and routine lab parameters suggestive of severe infection. [Int J Res Med Sci 2016; 4(4.000: 1216-1218

  7. Circulating cytokines and procalcitonin in acute Q fever granulomatous hepatitis with poor response to antibiotic and short-course steroid therapy: a case report

    Chang Lin-Li

    2010-07-01

    Full Text Available Abstract Background Q fever is a zoonosis distributed worldwide that is caused by Coxiella burnetii infection and the defervescence usually occurs within few days of appropriate antibiotic therapy. Whether the changes of cytokine levels are associated with acute Q fever with persistent fever despite antibiotic therapy had not been investigated before. Case Presentation We report a rare case of acute Q fever granulomatous hepatitis remained pyrexia despite several antibiotic therapy and 6-day course of oral prednisolone. During the 18-month follow-up, the investigation of the serum cytokines profile and procalcitonin (PCT revealed that initially elevated levels of interleukin-2 (IL-2, IL-8, IL-10, and PCT decreased gradually, but the IL-6 remained in low titer. No evidence of chronic Q fever was identified by examinations of serum antibodies against C. burnetii and echocardiography. Conclusions The changes of cytokine levels may be associated with acute Q fever with poor response to treatment and PCT may be an indicator for monitoring the response to treatment.

  8. The value of procalcitonin in diagnosis of neonatal infection%降钙素原对新生儿感染的诊断价值

    齐华雪

    2012-01-01

    Neonatal infection is one of the important reasons for newborns mortality.The current diagnosis indicators of neonatal infection have differences in the sensitivity and specificity,respectively.In recent years,procalcitonin (PCT) is widely used in the diagnosis of various infectious diseases.Studies showed that the PCT had higher sensitivity and specificity in the early diagnosis of neonatal infection.Serum PCT level is associated with the severity of neonatal infection,the development and the prognosis of the disease.It can be used to evaluate the effect of treatment and the prognosis.During the period of neonatal,the serum PCT is not affected by the level of maternal and the acute inflammatory response which caused by injuries and asphyxia,and it is associated with the severity of newborn bacterial infection.PCT has special significance to the diagnosis of neonatal infection.%新生儿感染是引起新生儿死亡的重要原因.目前感染检测指标对新生儿感染的诊断在灵敏性、特异性等方面各有差异.近年来,降钙素原( procalcitonin,PCT)被广泛用于各种感染性疾病的诊断,对新生儿感染的早期诊断的灵敏性、特异性均较高,与新生儿感染的严重程度、感染的发展及疾病的预后具有相关性,可用来衡量治疗效果及预后评估.血清PCT在新生儿期不受母体血清PCT水平高低和窒息缺氧损伤引起的急性炎症反应的影响,仅与新生儿自身细菌感染严重程度有关,对新生儿感染的诊断具有特殊意义.

  9. Intérêt du dosage de la procalcitonine chez le sujet âgé

    Stucker, Fabien; Hermann, François; Krause, Karl-Heinz

    2007-01-01

    La procalcitonine a été étudiée à de nombreuses reprises chez l'adulte jeune présentant des infections bactérienne comme marqueur spécifique et précoce de l'inflammation, ainsi que comme prédicteur de la sévérité de l'atteinte. L'intérêt de son dosage chez la personne âgée n'a jamais été démontré. Une étude observationnelle a donc été conduite chez 218 patients âgés, non sélectionnés, admis en secteur hospitalier et les sensibilités (24%) et spécificité (94%) de la procalcitonine comme prédic...

  10. Intérêt du dosage de la procalcitonine chez le sujet âgé

    Stucker, Fabien

    2006-01-01

    La procalcitonine a été étudiée à de nombreuses reprises chez l'adulte jeune présentant des infections bactérienne comme marqueur spécifique et précoce de l'inflammation, ainsi que comme prédicteur de la sévérité de l'atteinte. L'intérêt de son dosage chez la personne âgée n'a jamais été démontré. Une étude observationnelle a donc été conduite chez 218 patients âgés, non sélectionnés, admis en secteur hospitalier et les sensibilités (24%) et spécificité (94%) de la procalcitonine comme prédic...

  11. Antibiotic Discontinuation Rates Associated with Positive Respiratory Viral Panel and Low Procalcitonin Results in Proven or Suspected Respiratory Infections

    Timbrook, Tristan; Maxam, Meshell; Bosso, John

    2015-01-01

    Introduction The differentiation of viral from bacterial pneumonia is important in determining whether antibiotics are appropriate for treatment of these infections. Advances in diagnostic technologies such as respiratory panels (RP) utilizing polymerase chain reactions to detect viruses and determination of procalcitonin (PCT) concentrations may aid in this differentiation. However, some studies have shown limited impact for this purpose and thus continuation of antibiotics despite results s...

  12. Procalcitonin for the differential diagnosis of infectious and non-infectious systemic inflammatory response syndrome after cardiac surgery

    Zhao, Dong; Zhou, Jianxin; Haraguchi, Go; Arai, Hirokuni; Mitaka, Chieko

    2014-01-01

    Background This study was performed to assess the value of procalcitonin (PCT) for the differential diagnosis between infectious and non-infectious systemic inflammatory response syndrome (SIRS) after cardiac surgery. Methods Patients diagnosed with SIRS after cardiac surgery between April 1, 2011 and March 31, 2013 were retrospectively studied. A total of 142 patients with SIRS, infectious (n = 47) or non-infectious (n = 95), were included. The patients with infectious SIRS included 11 with ...

  13. Infection biomarkers in primary care patients with acute respiratory tract infections–comparison of Procalcitonin and C-reactive protein

    Meili, Marc; Kutz, Alexander; Briel, Matthias; Christ-Crain, Mirjam; Bucher, Heiner C.; Mueller, Beat; Schuetz, Philipp

    2016-01-01

    Background There is a lack of studies comparing the utility of C-reactive protein (CRP) with Procalcitonin (PCT) for the management of patients with acute respiratory tract infections (ARI) in primary care. Our aim was to study the correlation between these markers and to compare their predictive accuracy in regard to clinical outcome prediction. Methods This is a secondary analysis using clinical and biomarker data of 458 primary care patients with pneumonic and non-pneumonic ARI. We used co...

  14. Hubungan Kadar Procalcitonin dengan Jenis Bakteri Penyebab Infeksi pada Sepsis di RSUP H. Adam Malik Tahun 2014

    Paulus

    2016-01-01

    Sepsis is a condition where systemic inflammation response syndrome which is caused by invasion of bacteria, virus, fungi or paracites. In America, the incidence of post operation sepsis increased three times, from 0,3% to 0,9%. Sepsis could be diagnosed with some marker examination, such as procalcitonin, CRP, Erythrocyte Sedimentation Rate (ESR) and white blood count, with microorganism culture as gold standard. The purpose of this research is to know the relationship betw...

  15. Point-of-care procalcitonin test to reduce antibiotic exposure in patients hospitalized with acute exacerbation of COPD

    Corti, Caspar

    2016-01-01

    Caspar Corti,1 Markus Fally,1 Andreas Fabricius-Bjerre,1 Katrine Mortensen,1 Birgitte Nybo Jensen,1 Helle F Andreassen,1 Celeste Porsbjerg,1 Jenny Dahl Knudsen,2 Jens-Ulrik Jensen1 1Department of Respiratory Medicine, Copenhagen University Hospital Bispebjerg, Copenhagen, 2Department of Clinical Microbiology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark Background: This study was conducted to investigate whether point-of-care (POC) procalcitonin (PCT) measurement can reduce re...

  16. C-reactive protein and procalcitonin predict anastomotic leaks following colorectal cancer resections – a prospective study

    Zawadzki, Marek; Czarnecki, Roman; Rzaca, Marek; Obuszko, Zbigniew; Velchuru, Vamsi Ramana; Witkiewicz, Wojciech

    2016-01-01

    Introduction Early safe discharge is paramount for the success of ERAS following colorectal cancer resections. Anastomotic leakage (AL) has high morbidity, particularly if the patient has been discharged to the community. Aim To evaluate whether C-reactive protein (CRP) and procalcitonin (PCT) can predict AL before early discharge. Material and methods Fifty-five consecutive patients undergoing open and robotic colorectal cancer resections were included. C-reactive protein and PCT were measur...

  17. Identification of 9 uterine genes that are regulated during mouse pregnancy and exhibit abnormal levels in the cyclooxygenase-1 knockout mouse

    Soper Jessica

    2007-07-01

    Full Text Available Abstract Background Preterm birth is the leading cause of all infant mortality. In 2004, 12.5% of all births were preterm. In order to understand preterm labor, we must first understand normal labor. Since many of the myometrial changes that occur during pregnancy are similar in mice and humans and mouse gestation is short, we have studied the uterine genes that change in the mouse during pregnancy. Here, we used microarray analysis to identify uterine genes in the gravid mouse that are differentially regulated in the cyclooxygenase-1 knockout mouse model of delayed parturition. Methods Gestational d18.0 uteri (n = 4 were collected from pregnant wild-type and cyclooxygenase-1 knockout mice. Part of the uterus was used for frozen sections and RNA was isolated from the remainder. Microarray analysis was performed at the Indiana University School of Medicine Genomic Core and analyzed using the Microarray Data Portal. Northern analysis was performed to confirm microarray data and the genes localized in the gravid uterus by in situ hybridization. Results We identified 277 genes that are abnormally expressed in the gravid d18.0 cyclooxygenase-1 knockout mouse. Nine of these genes are also regulated in the normal murine uterus during the last half of gestation. Many of these genes are involved in the immune response, consistent with an important role of the immune system in parturition. Expression of 4 of these genes; arginase I, IgJ, Tnfrsf9 and troponin; was confirmed by Northern analysis to be mis-regulated during pregnancy in the knockout mouse. In situ hybridization of these genes demonstrated a similar location in the gravid wild-type and Cox-1 knockout mouse uteri. Conclusion To our knowledge, this is the first work to demonstrate the uterine location of these 4 genes in the mouse during late pregnancy. There are several putative transcription factor binding sites that are shared by many of the 9 genes identified here including; estrogen and

  18. Chromosomal Abnormalities in ADHD

    J Gordon Millichap

    2002-07-01

    Full Text Available The prevalence of fragile X syndrome, velocardiofacial syndrome (VCFS, and other cytogenetic abnormalities among 100 children (64 boys with combined type ADHD and normal intelligence was assessed at the NIMH and Georgetown University Medical Center.

  19. Chromosomal abnormalities and autism

    Farida El-Baz

    2016-01-01

    Conclusion: Chromosomal abnormalities were not detected in the studied autistic children, and so the relation between the genetics and autism still needs further work up with different study methods and techniques.

  20. Prognosis Evaluation of Lactate Clearance Rate and Procalcitonin Clearance Rate in Patients with Septic Shock:A Retrospective Study%乳酸清除率联合降钙素原清除率对脓毒症休克患者预后的回顾性研究

    梁炼; 张云

    2016-01-01

    目的:回顾性研究乳酸清除率联合降钙素原清除率在脓毒症休克患者预后中的作用。方法:2015年1月至2015年12月中山大学孙逸仙纪念医院 ICU 收治的78例脓毒症休克患者,包括存活组54例、死亡组24例。记录患者临床特征、入ICU时液体复苏开始前的乳酸值(Lac0)和降钙素原值(PCT0)、入ICU第1个24小时内液体复苏完成后的乳酸值(Lac24)和降钙素原值(PCT24),并计算乳酸清除率和降钙素原清除率,通过受试者工作特征曲线(ROC)分析各指标的预测效度。结果:乳酸清除率组和降钙素原清除率组两者联合,在预测脓毒症休克患者28 d 全因病死率时,可以达到非常高的 AUC 值(0.911)。结论:乳酸清除率联合降钙素原清除率对脓毒症休克患者预后的预测价值最佳。%Objective: To evaluate the prognostic effect of lactate clearance rate and procalcitonin clearance rate in patients with septic shock retrospectively. Methods: 78 patients with septic shock admitted from January 2015 to December 2015 in Sun Yat-Sen Memorial Hospital, Sun Yat- Sen University. All the patients were divided into 2 groups according to the outcome: survival group and the death group. The general condition and clinical characteristics, lactate levels (Lac0)and procalcitonin levels (PCT0) on arrival in ICU, lactate levels (Lac24)and procalcitonin levels (PCT24) after fluid resuscitation during the first hour, lactate clearance rate and procalcitonin clearance rate were calculated. Results: the area under ROC curve was the largest (0.911) when ran with lactate clearance rate and procalcitonin clearance rate, suggesting its accuracy for predicting patients’ 28-day mortality. Conclusion: The lactate clearance rate combined with procalcitonin clearance rate become the best evaluation value for patients’ prognosis in our study.

  1. Clinical value of C-reactive protein and procalcitonin in diagnosis of children′s infectious diseases%C-反应蛋白与降钙素原在儿童感染性疾病中的诊断价值

    张福蓉; 刘瑶; 王方芳

    2015-01-01

    OBJECTIVE To detect content of C‐reactive protein and procalcitonin in children with sepsis ,blood‐stream infections and other infectious diseases ,so as to explore their clinical diagnostic values .METHODS From Mar .2013-to Mar .2014 ,totally 90 cases of children with systemic inflammatory response syndromes were se‐lected and divided into sepsis group and non‐sepsis group with 45 cases each .The content of C‐reactive protein and procalcitonin in these children were detected and the data were analyzed by SPSS 19 .0 software .RESULTS C‐reac‐tive protein content in the sepsis group was averagely (119 .34 ± 17 .34) mg/L ,and the procalcitonin was averagely (11 .92 ± 1 .59)μg/L .In the non‐sepsis group ,the average level of C‐reactive protein was (46 .12 ± 16 .60) mg/L ,and the average level of procalcitonin was (1 .41 ± 0 .42)μg/L .Sepsis group had a obviously higher C‐reactive protein level and procalcitonin level than non‐sepsis group (P<0 .05) .CONCLUSION C‐reactive protein and pro‐calcitonin is certainly effective in the early diagnosis of bloodstream infections and other infectious diseases in chil‐dren with sepsis ,especially procalcitonin .Hence they can be used widely in clinical practice .%目的:分析C‐反应蛋白与降钙素原在小儿脓毒症血流感染及其他部位感染性疾病中的含量,从而探讨其临床诊断价值。方法选取2013年3月-2014年3月小儿全身炎症反应综合征患儿90例,分为脓毒症组和非脓毒症组,患儿各45例;测定患儿C‐反应蛋白与降钙素原含量,数据采用SPSS 19.0软件进行统计分析。结果脓毒症组C‐反应蛋白为(119.34±17.34)m g/L、降钙素原为(11.92±1.59)μg/L ;非脓毒症组C‐反应蛋白为(46.12±16.60)m g/L、降钙素原为(1.41±0.42)μg/L ,脓毒症组明显高于非脓毒症组,差异有统计学意义( P<0.05)。结论 C‐反应蛋白与降钙

  2. 炎症标记物(C 反应蛋白和降钙素原)与颅内感染患者预后的关系%Relationship between the Inflammatory Markers (C-reactive protein and Procalcitonin) and Prognosis of Patients with In-tracranial Infection

    王苏

    2015-01-01

    Objective :To study and investigate the relationship between the inflammatory markers (C‐reactive protein and procalcitonin) and prognosis of patients with intracranial infection .Methods :54 patients with intracranial infection in our hospital from March 2012 to March 2014 were selected as observation group ,54 healthy persons with health ex‐amination at the same time were the control group ,then the serum C‐reactive protein and procalcitonin levels and posi‐tive rates of two groups were respectively analyzed and compared ,then compared to the serum C‐reactive protein and procalcitonin levels and positive rates of observation group with different infection degree and treatment effect were re‐spectively .Results:The serum C‐reactive protein and procalcitonin levels and positive rates of observation group were all respectively higher than those of control group ,and the serum C‐reactive protein and procalcitonin levels and positive rates of observation group with severe infection and worse treatment effect were respectively higher than those of pa‐tients with mild infection and better treatment effect ,all P<0 .05 ,there were all significant differences .Conclusion:The serum C‐reactive protein and procalcitonin have higher clinical detection value for the intracranial infection ,and it can effectively react the prognosis of patients with intracranial infection .%目的:探讨炎症标记物(C反应蛋白和降钙素原)与颅内感染患者预后的关系。方法:选取2012年3月-2014年3月于本院进行诊治的54例颅脑感染患者为观察组,同期54名体检健康者为对照组,然后将两组的血清C反应蛋白和降钙素原水平及阳性率分别进行统计及比较,同时比较观察组中不同感染程度及治疗效果患者的血清C反应蛋白和降钙素原水平及阳性率。结果:观察组的血清C反应蛋白和降钙素原水平及阳性率均高于对照组,观察组中感染较重及治疗

  3. Application value for severity assessment and prognosis of procalcitonin in patients with traumatic brain injury%前降钙素在创伤性脑损伤患者病情评估和预后判断中的应用价值

    赵军; 高新疆; 任传斌

    2014-01-01

    Objective To explore the application value for severity assessment and prognosis of procalcitonin in pa-tients with traumatic brain injury.Methods 92 patients with traumatic brain injury from March 2010 to March 2013 in our hospital were chosen.According to the Glasgow coma score (GCS),the patients were divided into mild brain injury group (53 cases)and severe brain injury group (39 cases).At the same time,the patients were divided into infected group (39 cases)and non infected group (53 cases)according to whether infected within a week.The level of procalci-tonin of the subjects were detected on 1,3,5,7 days of hospitalization and compared between mild brain injury group and severe brain injury group,infected group and non infected group.Kaplan-Meiers survival analysis was used to ana-lyze the relationship between level of procalcitonin and 28 days survival.Results The levels of procalcitonin of subjects in severe brain injury group on 1,3,5,7 days were all significantly higher than those of patients in mild brain injury group (all P <0.05).The GCS scores of patients were negatively correlated with level of procalcitonin (r=0.532,P <0.05).The levels of procalcitonin of subjects in infected group on 3,5,7 days were all significantly higher than those of non infected group (all P <0.05).The 28-days survival rate of patients with normal levels of procalcitonin in admission was significantly higher than the patients with high levels of procalcitonin (χ2 =5.821,P =0.016).Conclusion It has guiding significance of dynamic monitoring of levels of procalcitonin in evaluation of severity of traumatic brain injury, infection diagnosis and the prognosis.%目的:探讨前降钙素在创伤性脑损伤患者病情评估和预后判断中的应用价值。方法选择2010年3月-2013年3月期间我院收治的创伤性脑损伤患者92例,根据入院时格拉斯哥昏迷指数评分分为轻度脑损伤组(53例)和重度脑损伤组(39例)

  4. Procalcitonin and C-reactive protein cannot differentiate bacterial or viral infection in COPD exacerbation requiring emergency department visits

    Chang CH

    2015-04-01

    Full Text Available Chih-Hao Chang,1 Kuo-Chien Tsao,2,3 Han-Chung Hu,1,4 Chung-Chi Huang,1,4 Kuo-Chin Kao,1,4 Ning-Hung Chen,1,4 Cheng-Ta Yang,1,4 Ying-Huang Tsai,4,5 Meng-Jer Hsieh4,51Department of Pulmonary and Critical Care Medicine, Linkou Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Chang-Gung University College of Medicine, Taoyuan, Taiwan; 2Department of Laboratory Medicine, Linkou Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation; 3Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan; 4Department of Respiratory Therapy, Chang-Gung University, Taoyuan, Taiwan; 5Department of Pulmonary and Critical Care Medicine, Chiayi Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Puzi City, TaiwanBackground: Viral and bacterial infections are the most common causes of chronic obstructive pulmonary disease (COPD exacerbations. Whether serum inflammatory markers can differentiate bacterial from virus infection in patients with COPD exacerbation requiring emergency department (ED visits remains controversial.Methods: Viral culture and polymerase chain reaction (PCR were used to identify the viruses in the oropharynx of patients with COPD exacerbations. The bacteria were identified by the semiquantitative culture of the expectorated sputum. The peripheral blood white blood cell (WBC counts, serum C-reactive protein (CRP, procalcitonin (PCT, and clinical symptoms were compared among patients with different types of infections.Results: Viruses were isolated from 16 (22.2% of the 72 patients enrolled. The most commonly identified viruses were parainfluenza type 3, influenza A, and rhinovirus. A total of 30 (41.7% patients had positive bacterial cultures, with the most commonly found bacteria being Haemophilus influenzae and Haemophilus parainfluenzae. Five patients (6.9% had both positive sputum cultures and virus identification. The WBC, CRP, and PCT levels of the bacteria-positive and bacteria

  5. Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 and Procalcitonin Can Reflect Sepsis Severity and Predict Prognosis: A Prospective Cohort Study

    Zhenyu Li

    2014-01-01

    Full Text Available Objective. To investigate the prognostic significance of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1, procalcitonin (PCT, N-terminal probrain natriuretic peptide (NT-pro-BNP, C-reactive protein (CRP, cytokines, and clinical severity scores in patients with sepsis. Methods. A total of 102 patients with sepsis were divided into survival group (n=60 and nonsurvival group (n=42 based on 28-day mortality. Serum levels of biomarkers and cytokines were measured on days 1, 3, and 5 after admission to an ICU, meanwhile the acute physiology and chronic health evaluation II (APACHE II and sequential organ failure assessment (SOFA scores were calculated. Results. Serum sTREM-1, PCT, and IL-6 levels of patients in the nonsurvival group were significantly higher than those in the survival group on day 1 (P<0.01. The area under a ROC curve for the prediction of 28 day mortality was 0.792 for PCT, 0.856 for sTREM-1, 0.953 for SOFA score, and 0.923 for APACHE II score. Multivariate logistic analysis showed that serum baseline sTREM-1 PCT levels and SOFA score were the independent predictors of 28-day mortality. Serum PCT, sTREM-1, and IL-6 levels showed a decrease trend over time in the survival group (P<0.05. Serum NT-pro-BNP levels showed the predictive utility from days 3 and 5 (P<0.05. Conclusion. In summary, elevated serum sTREM-1 and PCT levels provide superior prognostic accuracy to other biomarkers. Combination of serum sTREM-1 and PCT levels and SOFA score can offer the best powerful prognostic utility for sepsis mortality.

  6. 前降钙素在临床外科中的应用前景%Application of procalcitonin in clinical surgery

    徐林; 张应天

    2012-01-01

    Procalcitonin is a biomarker to diagnose the extent and severity of systemic bacterial infection.Procalcitonin is applied in diagnosis and treatment of systemic inflammatory response syndrome and severe acute pancreatitis.The article reviews application of procalcitonin in clinical surgery and guides use of anti-bacterial agents.%前降钙素是一种判断全身感染的标志物,临床上已广泛的应用于脓毒症及急性胰腺炎的诊断治疗中.本文简要综述前降钙素在临床外科中的应用,以助于临床医师判断细菌感染,指导抗生素的应用.

  7. Abnormal Changes of Brain Cortical Anatomy and the Association with Plasma MicroRNA107 Level in Amnestic Mild Cognitive Impairment

    Wang, Tao; Shi, Feng; Jin, Yan; Jiang, Weixiong; Shen, Dinggang; Xiao, Shifu

    2016-01-01

    MicroRNA107 (Mir107) has been thought to relate to the brain structure phenotype of Alzheimer’s disease. In this study, we evaluated the cortical anatomy in amnestic mild cognitive impairment (aMCI) and the relation between cortical anatomy and plasma levels of Mir107 and beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1). Twenty aMCI (20 aMCI) and 24 cognitively normal control (NC) subjects were recruited, and T1-weighted MR images were acquired. Cortical anatomical measurements, including cortical thickness (CT), surface area (SA), and local gyrification index (LGI), were assessed. Quantitative RT-PCR was used to examine plasma expression of Mir107, BACE1 mRNA. Thinner cortex was found in aMCI in areas associated with episodic memory and language, but with thicker cortex in other areas. SA decreased in aMCI in the areas associated with working memory and emotion. LGI showed a significant reduction in aMCI in the areas involved in language function. Changes in Mir107 and BACE1 messenger RNA plasma expression were correlated with changes in CT and SA. We found alterations in key left brain regions associated with memory, language, and emotion in aMCI that were significantly correlated with plasma expression of Mir107 and BACE1 mRNA. This combination study of brain anatomical alterations and gene information may shed lights on our understanding of the pathology of AD. Clinical Trial Registration: http://www.ClinicalTrials.gov, identifier NCT01819545. PMID:27242521

  8. Epidemiological investigation of the serum lipid level and its abnormality in the residents in Malu Community%马陆镇居民血脂水平和异常流行病学调查

    翁立立; 陆萍

    2014-01-01

    目的:调查嘉定区马陆镇30岁以上居民血脂水平和异常现状,为社区心脑血管疾病防治提供资料。方法:对辖区7014名健康体检者检测血脂水平,分析血脂异常与性别、年龄段关系。结果:TC、TG、HDL-C及LDL-C水平分别为(5.08±1.01)mmol/L、(1.51±1.19)mmol/L、(1.46±0.38)mmol/L、(3.07±0.85) mmol/L;异常率分别为41.2%、13.5%、10.1%、31.7%。结论:马陆镇30岁以上居民血脂异常率高,以高TC、LDL-C为主,应做好早期综合防治。%Objective:To investigate the lipid level and its abnormality in the residents over the age of 30 in Malu Town, Jiading District to provide the information for the community to prevent and treat the cardiovascular diseases. Methods:The serum lipid was detected, and its abnormality, gender and age were analyzed. Results:The levels of TC, TG, HDL-C and LDL-C were (5.08±1.01) mmol/L, (1.51±1.19) mmol/L, (1.46±0.38) mmol/L, and (3.07±0.85) mmol/L, whose abnormal rates were 41.2%, 13.5%, 10.1%and 31.7%, respectively. Conclusion:The rates of dyslipidemia of the residents over the age of 30 in Malu Town are high and TC, and LDL-C are higher among them mainly. The early comprehensive prevention and treatment should be prepared.

  9. Neurological abnormalities predict disability

    Poggesi, Anna; Gouw, Alida; van der Flier, Wiesje;

    2014-01-01

    To investigate the role of neurological abnormalities and magnetic resonance imaging (MRI) lesions in predicting global functional decline in a cohort of initially independent-living elderly subjects. The Leukoaraiosis And DISability (LADIS) Study, involving 11 European centres, was primarily aimed...... at evaluating age-related white matter changes (ARWMC) as an independent predictor of the transition to disability (according to Instrumental Activities of Daily Living scale) or death in independent elderly subjects that were followed up for 3 years. At baseline, a standardized neurological examination...... abnormality independently predicted transition to disability or death [HR (95 % CI) 1.53 (1.01-2.34)]. The hazard increased with increasing number of abnormalities. Among MRI lesions, only ARWMC of severe grade independently predicted disability or death [HR (95 % CI) 2.18 (1.37-3.48)]. In our cohort...

  10. Procalcitonin determined at emergency department as an early indicator of progression to septic shock in patient with sepsis associated with ureteral calculi

    Ko, Young Hwii; Ji, Yoon Seob; Park, Sin-Youl; Kim, Su Jin; Song, Phil Hyun

    2016-01-01

    ABSTRACT Introduction: To investigate the role of initial procalcitonin (PCT) level as an early predictor of septic shock for the patient with sepsis induced by acute pyelonephritis (APN) secondary to ureteral calculi. Materials and Methods: The data from 49 consecutive patients who met criteria of sepsis due to APN following ureteral stone were collected and divided into two groups: with (n=15) or without (n=34) septic shock. The clinical variables including PCT level for this outcome were retrospectively compared by univariate analysis, followed by multivariable logistic regression model. Results: All subjects had hydronephrosis, and were hospitalized with the mean of 11.8 days (3–42 days). The mean size of the ureteral stones was 7.5mm (3–30mm), and 57% were located in upper ureter. At univariate analysis, patients with septic shock were significantly older, a higher proportion had hypertension, lower platelet count and serum albumin level, higher CRP and PCT level, and higher positive blood culture rate. Multivariate models indicated that lower platelet count and higher PCT level are independent risk factors (p=0.043 and 0.046, respectively). In ROC curve, the AUC was significantly wider in PCT (0.929), compared with the platelet count (0.822, p=0.004). At the cut-off of 0.52ng/mL, the sensitivity and specificity were 86.7% and 85.3%. Conclusion: Our study demonstrated elevated initial PCT levels as an early independent predictor to progress into septic shock in patients with sepsis associated with ureteral calculi. PMID:27256181

  11. CT of pleural abnormalities

    Briefly discussed were CT diagnosis of pleural thickening, CT technique for examining the pleura or pleuro-pulmonary disease, diagnosis of pleural collections, diagnosis of pleural fluid abnormalities in patients with pneumonia, pleural neoplasms, malignant (diffuse) mesothelioma, metastases, local fibrous tumor of the pleura (benign mesothelioma) (21 refs.)

  12. Dual-Quantum-Dots-Labeled Lateral Flow Strip Rapidly Quantifies Procalcitonin and C-reactive Protein

    Qi, XiaoPing; Huang, YunYe; Lin, ZhongShi; Xu, Liang; Yu, Hao

    2016-03-01

    In the article, a dual-quantum-dots-labeled (dual-QDs-labeled) lateral flow strip (LFS) method was developed for the simultaneous and rapid quantitative detection of procalcitonin (PCT) and C-reactive protein (CRP) in the blood. Two QD-antibody conjugates with different fluorescence emission spectra were produced and sprayed on the LFS to capture PCT and CRP in the blood. Furthermore, a double antibody sandwich method for PCT and, meanwhile, a competitive inhibition method for CRP were employed in the LFS. For PCT and CRP in serum assayed by the dual-QDs-labeled LFS, their detection sensitivities reached 0.1 and 1 ng/mL, respectively, and their linear quantitative detection ranges were from 0.3 to 200 ng/mL and from 50 to 250 μg/mL, respectively. There was little evidence that the PCT and CRP assays would be interfered with each other. The correlations for testing CRP and PCT in clinical samples were 99.75 and 97.02 %, respectively, between the dual-QDs-labeled LFS we developed and commercial methods. The rapid quantification of PCT and CRP on dual-QDs-labeled LFS is of great clinical value to distinguish inflammation, bacterial infection, or viral infection and to provide guidance for the use of antibiotics or other medicines.

  13. [Diagnostic value of the procalcitonine test in purulent-septic complications of chest traumas].

    Vadachkoriia, V K; Gogishvili, Sh G; Shapatava, K K

    2007-04-01

    The aim of the present work was to assess the value of the semi-quantitative procalcitonine test (PCT) in diagnosis of purulent-septic complications of chest traumas, efficacy of the therapy carried out, and outcome prognosis. For this, 71 patients with chest traumas were enrolled in the study. Concentrations of PCT were assessed in dynamics using an immunochromatographic, semi-quantitative quick test. Semi-quantitative quick PCT test is highly sensitive diagnostic marker that can be used for the assessment of a chest trauma, infectious-septic complication severity, and efficiency of the therapy indicated. Thus, it can be successfully used for monitoring trauma therapy. PCT sensitivity during first 12 hrs of infectious-septic complication development is 2-3-times higher than that of routine methods for laboratory diagnostics, and even more sensitive that IL-6 and CRT, when we are dealing with combined chest traumas. PCT concentration increase is 4-times more frequent in gram-positive bacterial processes than in gram-negative ones. This has to be taken into account, when appropriate antibacterial treatment is selected for restricted infectious-septic complications. PMID:17525495

  14. The First Trimester Gravid Serum Regulates Procalcitonin Expression in Human Macrophages Skewing Their Phenotype In Vitro

    Damiano Rami

    2014-01-01

    Full Text Available Procalcitonin (PCT is one of the best diagnostic and prognostic markers in clinical practice, widely used to evaluate the evolution of bacterial infections. Although it is mainly produced by thyroid, during sepsis almost all the peripheral tissues are involved in PCT production. Parenchymal cells have been suggested as the main source of PCT expression; however the contribution of macrophages is not clear yet. In response to environmental cues, tissue macrophages acquire distinct functional phenotypes, ranging from proinflammatory (M1 to anti-inflammatory (M2 phenotype. Macrophages at the fetal-maternal interface show immunosuppressive M2-like activities required for the maintenance of immunological homeostasis during pregnancy. This study aims to clarify the ability to synthesise PCT of fully differentiated (M0, polarized (M1/M2 macrophages and those cultured either in the presence of first trimester gravid serum (GS or pregnancy hormones. We found out that M1 macrophages upregulate PCT expression following LPS stimulation compared to M0 and M2. The GS downregulates PCT expression in macrophages, skewing them towards an M2-like phenotype. This effect seems only partially mediated by the hormonal milieu. Our findings strengthen the key role of macrophages in counteracting inflammatory stimuli during pregnancy, suggesting PCT as a possible new marker of M1-like macrophages.

  15. Procalcitonin Clearance for Early Prediction of Survival in Critically Ill Patients with Severe Sepsis

    Mohd Basri Mat Nor

    2014-01-01

    Full Text Available Introduction. Serum procalcitonin (PCT diagnosed sepsis in critically ill patients; however, its prediction for survival is not well established. We evaluated the prognostic value of dynamic changes of PCT in sepsis patients. Methods. A prospective observational study was conducted in adult ICU. Patients with systemic inflammatory response syndrome (SIRS were recruited. Daily PCT were measured for 3 days. 48 h PCT clearance (PCTc-48 was defined as percentage of baseline PCT minus 48 h PCT over baseline PCT. Results. 95 SIRS patients were enrolled (67 sepsis and 28 noninfectious SIRS. 40% patients in the sepsis group died in hospital. Day 1-PCT was associated with diagnosis of sepsis (AUC 0.65 (95% CI, 0.55 to 0.76 but was not predictive of mortality. In sepsis patients, PCTc-48 was associated with prediction of survival (AUC 0.69 (95% CI, 0.53 to 0.84. Patients with PCTc-48 > 30% were independently associated with survival (HR 2.90 (95% CI 1.22 to 6.90. Conclusions. PCTc-48 is associated with prediction of survival in critically ill patients with sepsis. This could assist clinicians in risk stratification; however, the small sample size, and a single-centre study, may limit the generalisability of the finding. This would benefit from replication in future multicentre study.

  16. Investigation of The Association between Salivary Procalcitonin Concentration and Chronic Periodontitis

    Hojatollah Yousefimanesh

    2015-10-01

    Full Text Available Objective: Chronic periodontitis is the most common form of periodontal disease. Changes in biomarkers seem to be associated with the disease progression. Procalcitonin (PCT is one of these biomarkers that are altered during infection. This study was established to investigate the relationship between periodontitis as an infectious disease and salivary PCT. Materials and Methods: This case-control study was performed on 30 patients with generalized chronic periodontitis and 30 health individuals as control group who were referred to Dental School, Jundishapur University of Ahvaz, Ahvaz, Iran at Feb to Apr 2014. The saliva samples were collected and analyzed by the enzyme-linked immunosorbent assay (ELISA method. Data analysis was performed using t test with the SPSS (SPSS Inc., Chicago, IL, USA version 13. Results: In both groups, age and sex distribution values were not significantly different. The concentrations of salivary PCT in controls and patients ranged from 0.081 pg/ mL to 0.109 pg/mL and from 0.078 pg/mL to 0.114 pg/mL, respectively. The statistically significant differences between the two groups were not observed (P=0.17. Conclusion: It seems that salivary PCT concentration is not affected by disease progression. Therefore, PCT is not a valuable marker for the existence of periodontal disease.

  17. Dual-Quantum-Dots-Labeled Lateral Flow Strip Rapidly Quantifies Procalcitonin and C-reactive Protein.

    Qi, XiaoPing; Huang, YunYe; Lin, ZhongShi; Xu, Liang; Yu, Hao

    2016-12-01

    In the article, a dual-quantum-dots-labeled (dual-QDs-labeled) lateral flow strip (LFS) method was developed for the simultaneous and rapid quantitative detection of procalcitonin (PCT) and C-reactive protein (CRP) in the blood. Two QD-antibody conjugates with different fluorescence emission spectra were produced and sprayed on the LFS to capture PCT and CRP in the blood. Furthermore, a double antibody sandwich method for PCT and, meanwhile, a competitive inhibition method for CRP were employed in the LFS. For PCT and CRP in serum assayed by the dual-QDs-labeled LFS, their detection sensitivities reached 0.1 and 1 ng/mL, respectively, and their linear quantitative detection ranges were from 0.3 to 200 ng/mL and from 50 to 250 μg/mL, respectively. There was little evidence that the PCT and CRP assays would be interfered with each other. The correlations for testing CRP and PCT in clinical samples were 99.75 and 97.02 %, respectively, between the dual-QDs-labeled LFS we developed and commercial methods. The rapid quantification of PCT and CRP on dual-QDs-labeled LFS is of great clinical value to distinguish inflammation, bacterial infection, or viral infection and to provide guidance for the use of antibiotics or other medicines. PMID:27013227

  18. Making chromosome abnormalities treatable conditions.

    Cody, Jannine DeMars; Hale, Daniel Esten

    2015-09-01

    Individuals affected by the classic chromosome deletion syndromes which were first identified at the beginning of the genetic age, are now positioned to benefit from genomic advances. This issue highlights five of these conditions (4p-, 5p-, 11q-, 18p-, and 18q-). It focuses on the increased in understanding of the molecular underpinnings and envisions how these can be transformed into effective treatments. While it is scientifically exciting to see the phenotypic manifestations of hemizygosity being increasingly understood at the molecular and cellular level, it is even more amazing to consider that we are now on the road to making chromosome abnormalities treatable conditions. PMID:26351122

  19. Monitoring procalcitonin in febrile neutropenia: what is its utility for initial diagnosis of infection and reassessment in persistent fever?

    James Owen Robinson

    Full Text Available BACKGROUND: Management of febrile neutropenic episodes (FE is challenged by lacking microbiological and clinical documentation of infection. We aimed at evaluating the utility of monitoring blood procalcitonin (PCT in FE for initial diagnosis of infection and reassessment in persistent fever. METHODS: PCT kinetics was prospectively monitored in 194 consecutive FE (1771 blood samples: 65 microbiologically documented infections (MDI, 33.5%; 49 due to non-coagulase-negative staphylococci, non-CNS, 68 clinically documented infections (CDI, 35%; 39 deep-seated, and 61 fever of unexplained origin (FUO, 31.5%. RESULTS: At fever onset median PCT was 190 pg/mL (range 30-26'800, without significant difference among MDI, CDI and FUO. PCT peak occurred on day 2 after onset of fever: non-CNS-MDI/deep-seated-CDI (656, 80-86350 vs. FUO (205, 33-771; p500 pg/mL distinguished non-CNS-MDI/deep-seated-CDI from FUO with 56% sensitivity and 90% specificity. PCT was >500 pg/ml in only 10% of FUO (688, 570-771. A PCT peak >500 pg/mL (1196, 524-11950 occurred beyond 3 days of persistent fever in 17/21 (81% invasive fungal diseases (IFD. This late PCT peak identified IFD with 81% sensitivity and 57% specificity and preceded diagnosis according to EORTC-MSG criteria in 41% of cases. In IFD responding to therapy, median days to PCT <500 pg/mL and defervescence were 5 (1-23 vs. 10 (3-22; p = 0.026, respectively. CONCLUSION: While procalcitonin is not useful for diagnosis of infection at onset of neutropenic fever, it may help to distinguish a minority of potentially severe infections among FUOs on day 2 after onset of fever. In persistent fever monitoring procalcitonin contributes to early diagnosis and follow-up of invasive mycoses.

  20. Procalcitonin measurements and non-invasive mechanical ventilation in acute exacerbation of COPD: an appropriate new tool?

    Antonio M. Esquinas

    2014-02-01

    Full Text Available Hospitalization of acute exacerbations of chronic obstructive pulmonary disease (Ae-COPD is a common health care problem. In last decades, non-invasive mechanical ventilation (NIV is a key cornerstone therapeutic element that have shown influence positively short and long term outcomes in Ae-COPD. Recently, incorporation of new biomarkers as procalcitonin (PCT to predict requirement of NIV in Ae-COPD is an attractive tool to guide a proper making decision regarding indication of NIV is scarce. [Int J Res Med Sci 2014; 2(1.000: 373-374

  1. Prospective Evaluation of Procalcitonin, Soluble Triggering Receptor Expressed on Myeloid Cells-1 and C-Reactive Protein in Febrile Patients with Autoimmune Diseases

    Lin, Chou-Han; Hsieh, Song-Chou; Keng, Li-Ta; Lee, Ho-Sheng; Chang, Hou-Tai; Liao, Wei-Yu; Ho, Chao-Chi; Yu, Chong-Jen

    2016-01-01

    Background Both procalcitonin (PCT) and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) have been investigated separately as indicators of infection in patients with autoimmune diseases. Our study simultaneously evaluated both PCT and sTREM-1 along with C-reactive protein (CRP) in febrile patients with autoimmune diseases. Methods Fifty-nine patients were enrolled in the study. The patients were categorized into the infection group (n = 24) or the disease flare group (n = 35). sTREM-1, PCT and CRP concentrations at fever onset were compared between the two groups of patients. Results sTREM-1 and CRP did not differ between the two groups. PCT [median (range), ng/ml] was higher in the infection group than in the disease flare group [0.53 (0.02–12.85) vs. 0.12 (0.02–19.23), p = 0.001]. The area under the receiver-operating characteristic (ROC) for diagnosis of infection was 0.75 for PCT (p = 0.001), 0.63 for CRP (p = 0.09) and 0.52 for sTREM-1 (p = 0.79). Using 0.2 ng/ml as the cutoff value for PCT, sensitivity was 0.75 and specificity was 0.77. Negative predictive values for PCT were 92%, 87% and 82% for a prevalence of infection of 20%, 30%, and 40%, respectively. Neither immunosuppressants nor biomodulators affected the level of the three biomarkers. However, in patients treated with corticosteroids, the levels of sTREM-1 and CRP were significantly decreased compared with the untreated patients. Conclusions Setting PCT at a lower cutoff value could provide useful information on excluding infection in febrile patients with autoimmune diseases. The possible effect of corticosteroids on the level of sTREM-1 as an infection marker deserves further study. PMID:27096761

  2. Abnormal ionization in sonoluminescence

    张文娟; 安宇

    2015-01-01

    Sonoluminescence is a complex phenomenon, the mechanism of which remains unclear. The present study reveals that an abnormal ionization process is likely to be present in the sonoluminescing bubble. To fit the experimental data of previous studies, we assume that the ionization energies of the molecules and atoms in the bubble decrease as the gas density increases and that the decrease of the ionization energy reaches about 60%–70%as the bubble flashes, which is difficult to explain by using previous models.

  3. Ultrasonography of splenic abnormalities

    Ming-Jen Chen; Ming-Jer Huang; Wen-Hsiung Chang; Tsang-En Wang; Horng-Yuan Wang; Cheng-Hsin Chu; Shee-Chan Lin; Shou-Chuan Shih

    2005-01-01

    AIM: This report gives a comprehensive overview of ultrasonography of splenic abnormalities. Certain ultrasonic features are also discussed with pathologic correlation.METHODS: We review the typical ultrasonic characteristics of a wide range of splenic lesions, illustrating them with images obtained in our institution from 2000 to 2003.One hundred and three patients (47 men, 56 women),with a mean age of 54 years (range 9-92 years), were found to have an abnormal ultrasonic pattern of spleen.RESULTS: We describe the ultrasonic features of various splenic lesions such as accessory spleen, splenomegaly,cysts, cavernous hemangiomas, lymphomas, abscesses,metastatic tumors, splenic infarctions, hematomas, and rupture, based on traditional gray-scale and color Doppler sonography.CONCLUSION: Ultrasound is a widely available, noninvasive,and useful means of diagnosing splenic abnormalities. A combination of ultrasonic characteristics and clinical data may provide an accurate diagnosis. If the US appearance alone is not enough, US may also be used to guide biopsy of suspicious lesions.

  4. Application of Procalcitonin Detection in Infectious Diseases%降钙素原检测在感染性疾病中的应用进展

    黄远真

    2015-01-01

    降钙素原(procalcitonin,PCT)是目前备受关注的炎性检测指标,经过多年的实践应用,现已被广泛应用于临床诸多领域疾病的诊疗中.本文主要对降钙素原在急诊科、ICU、呼吸科、儿科及新生儿科、外科等相关临床科室的新应用情况作一综述,为临床感染性疾病的诊疗提供参考.%The procalcitonin (procalcitonin, PCT) is an inflammatory indexes of current concern, after years of practice, it has been widely applied in many fields in the clinical diagnosis and treatment of disease. In this paper, a new application of procalcitonin in the emergency department, ICU, Department of respiration, pediatrics and neonatology, surgery and other clinical departments were summarized, to provide a reference for the clinical diagnosis and treatment of infectious diseases.

  5. Antibiotic treatment interruption of suspected lower respiratory tract infections based on a single procalcitonin measurement at hospital admission-a randomized trial

    Kristoffersen, K B; Schmeltz Søgaard, Ole; Wejse, Christian;

    2009-01-01

    Recent studies have suggested that procalcitonin (PCT) is a safe marker for the discrimination between bacterial and viral infection, and that PCT-guided treatment may lead to substantial reductions in antibiotic use. The present objective was to evaluate the effect of a single PCT measurement on...

  6. Is serum procalcitonin measurement a useful addition to a rheumatologist's repertoire? A review of its diagnostic role in systemic inflammatory diseases and joint infections

    Shaikh, Muddassir Muhammad; Hermans, Lucas Etienne; Van Laar, Jacob M.

    2015-01-01

    Early differentiation between infection and aseptic inflammation is difficult and is a challenge often faced in the rheumatology practice. Procalcitonin (PCT) is a biomarker that is preferentially induced in patients with bacterial infections, and a growing body of evidence supports its use for impr

  7. Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial

    Jensen, Jens U; Hein, Lars; Lundgren, Bettina;

    2011-01-01

    For patients in intensive care units, sepsis is a common and potentially deadly complication and prompt initiation of appropriate antimicrobial therapy improves prognosis. The objective of this trial was to determine whether a strategy of antimicrobial spectrum escalation, guided by daily measure...... measurements of the biomarker procalcitonin, could reduce the time to appropriate therapy, thus improving survival....

  8. Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients : a randomised, controlled, open-label trial

    de Jong, Evelien; van Oers, Jos A; Beishuizen, Albertus; Vos, Piet; Vermeijden, Wytze J; Haas, Lenneke E; Loef, Bert G; Dormans, Tom; van Melsen, Gertrude C; Kluiters, Yvette C; Kemperman, Hans; van den Elsen, Maarten J; Schouten, Jeroen A; Streefkerk, Jörn O; Krabbe, Hans G; Kieft, Hans; Kluge, Georg H; van Dam, Veerle C; van Pelt, Joost; Bormans, Laura; Otten, Martine Bokelman; Reidinga, Auke C; Endeman, Henrik; Twisk, Jos W; van de Garde, Ewoudt M W; de Smet, Anne Marie G A; Kesecioglu, Jozef; Girbes, Armand R; Nijsten, Maarten W; de Lange, Dylan W

    2016-01-01

    BACKGROUND: In critically ill patients, antibiotic therapy is of great importance but long duration of treatment is associated with the development of antimicrobial resistance. Procalcitonin is a marker used to guide antibacterial therapy and reduce its duration, but data about safety of this reduct

  9. 降钙素原在血液透析患者导管相关性血行感染中的应用价值%The value of procalcitonin for the evaluation of catheter-related bloodstream infection in hemodialysis patients

    王芳; 潘淼; 李大勇; 刘小华; 陈晶; 谢鸣部; 黄智敏; 郑佩兰; 韦永光

    2013-01-01

    目的 研究降钙素原(Procalcitonin,PCT)在血液透析患者导管相关性血行感染(catheter related bloodstream infection,CRBSI)中的应用价值.方法 62例行中心静脉临时置管后临床怀疑导管相关性血行感染的血液透析患者,采集血常规、C反应蛋白(CRP)、降钙素原血样后拔除导管,同时留取血培养及导管标本.62例患者根据诊断标准分为CRBSI组27例和非CRBSI组35例,比较2组患者的年龄、性别、导管类型、导管留置时间、血白细胞计数(WBC)值、CRP值及降钙素原值(PCT值),并对比CRBSI组治疗前后的PCT值. 结果 CRBSI组患者年龄、导管留置时间明显大于非CRBSI组,CRBSI组及非CRBSI组拔管时的血清PCT水平分别为7.16±5.84μ g/L和0.97±1.44 μ g/L(F =11.759,t=5.387,P<0.001),具有统计学意义,其WBC (109/L)分别为9.52±3.10及8.65±2.19 (F =0.860 t=1.291 P=0.202),CRP值分别为10.57±3.74mg/L及10.66±4.94mg/L(F=1.641,t=0.081 P=0.935),2组均无统计学意义.CRBSI组拔管前后的降钙素原值(PCT值)分别为7.16±5.84 μ g/L及0.63±0.43 μ g/L (t=5.904,P<0.001),具有统计学意义. 结论 PCT在早期诊断CRBSI方面具有较高的指导价值.%Objective To study the value of procalcitonin for the evaluation of catheter-related bloodstream infection (CRBSI) in hemodialysis patients. Methods Blood samples from 62 hemodialysis patients suspected to have catheter-related bloodstream infection were obtained for the assays of blood routine examinations, procalcitonin and C-reactive protein (CRP). Blood and the catheter taken from the patients were cultured for bacteria. Patients were assigned into CRBSI group (n=27 cases) or non-CRBSI group (n=35 cases) based on the diagnostic criteria. Age, gender, catheter type, catheter retention period, WBC, CRP and procalcitonin were compared between the two groups. Procalcitonin levels were also compared before and after treatment. Results Age and catheter retention period were

  10. The Clinical Application of Procalcitonin%降钙素原的临床应用进展

    罗淑娟

    2012-01-01

    感染是临床上常见的病症,有效治疗的关键在于快速而准确地进行病原学诊断.降钙素原是降钙素的前体物质,作为一种炎性介质在细菌或真菌感染合并严重全身系统反应或器官低灌注时显著升高,而在病毒或局灶感染时水平正常或轻度升高,近年来成为鉴别细菌感染和其他病原体感染的新型标志物.现就其生物学特性、测量方法及临床应用予以综述.%Infection is a common disease, and the key to effective treatment is rapid and accurate diagnosis of pathogen. Procalcitonin, the precursor of calcitonin, as a mediator of inflammation, increases markedly in bacterial or fungal infection with severe system reaction or organ hypoperfusion, but is normal or elevates mildly in virus or focal infection. It has become a new marker for identification of bacterial infections and other pathogens. Here is to make a review' on the bionomics, measurements, and clinical application of procalcitonin.

  11. Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial

    Henzen Christoph

    2007-07-01

    Full Text Available Abstract Background: Lower respiratory tract infections like acute bronchitis, exacerbated chronic obstructive pulmonary disease and community-acquired pneumonia are often unnecessarily treated with antibiotics, mainly because of physicians' difficulties to distinguish viral from bacterial cause and to estimate disease-severity. The goal of this trial is to compare medical outcomes, use of antibiotics and hospital resources in a strategy based on enforced evidence-based guidelines versus procalcitonin guided antibiotic therapy in patients with lower respiratory tract infections. Methods and design: We describe a prospective randomized controlled non-inferiority trial with an open intervention. We aim to randomize over a fixed recruitment period of 18 months a minimal number of 1002 patients from 6 hospitals in Switzerland. Patients must be >18 years of age with a lower respiratory tract infections Discussion: Use of and prolonged exposure to antibiotics in lower respiratory tract infections is high. The proposed trial investigates whether procalcitonin-guidance may safely reduce antibiotic consumption along with reductions in hospitalization costs and antibiotic resistance. It will additionally generate insights for improved prognostic assessment of patients with lower respiratory tract infections. Trial registration: ISRCTN95122877

  12. Copeptin, procalcitonin and routine inflammatory markers-predictors of infection after stroke.

    Felix Fluri

    Full Text Available BACKGROUND: Early predictors for the development of stroke-associated infection may identify patients at high risk and reduce post-stroke infection and mortality. METHODS: In 383 prospectively enrolled acute stroke patients we assessed time point and type of post-stroke infections (i.e. pneumonia, urinary tract infection (UTI other infection (OI. Blood samples were collected on admission, and days 1, and 3 to assess white blood cells (WBC, monocytes, C-reactive protein (CRP, procalcitonin (PCT, and copeptin. To determine the magnitude of association with the development of infections, odds ratios (OR were calculated for each prognostic blood marker. The discriminatory ability of different predictors was assessed, by calculating area under the receiver operating characteristic curves (AUC. Prognostic models including the three parameters with the best performance were identified. RESULTS: Of 383 patients, 66 (17.2% developed an infection after onset of stroke. WBC, CRP, copeptin and PCT were all independent predictors of any infection, pneumonia and UTI developed at least 24 hours after measurements. The combination of the biomarkers WBC, CRP and copeptin (AUC: 0.92 and WBC, CRP and PCT (AUC: 0.90 showed a better predictive accuracy concerning the development of pneumonia during hospitalization compared to each marker by itself (p-Wald <0.0001. CONCLUSION: Among ischemic stroke patients, copeptin, PCT, WBC and CRP measured on admission were predictors of infection in general, and specifically for pneumonia and UTI within 5 days after stroke. The combination of these biomarkers improved the prediction of patients who developed an infection.

  13. Impact of hepatic function on serum procalcitonin for the diagnosis of bacterial infections in patients with chronic liver disease: A retrospective analysis of 324 cases.

    Qu, Junyan; Feng, Ping; Luo, Yan; Lü, Xiaoju

    2016-07-01

    Although procalcitonin (PCT) is a valid marker for early diagnosis of bacterial infections, it is unclear whether its accuracy in predicting bacterial infections is affected by impaired liver function. This study aimed to assess the impact of compromised liver function on the diagnostic value of PCT.This retrospective study was conducted between January 2013 and May 2015. A total of 324 patients with chronic liver disease were enrolled. Routine laboratory measurements and PCT were performed. Patients were divided into 3 groups according to clinical diagnosis: chronic hepatitis (group 1), decompensated cirrhosis (group 2), and acute-on-chronic liver failure/chronic liver failure (group 3). The correlation between PCT and liver function was analyzed. The area under the receiver operating characteristic (AUCROC) curve of PCT was analyzed according to infection status and liver function.PCT was more accurate than white blood cell count (P PCT had a moderate positive correlation with serum total bilirubin (TBIL) (r = 0.592), and a weak correlation with model for end-stage liver disease score (r = 0.483) and international normalized ratio (r = 0.389). The AUCROC and optimum thresholds of PCT and for predicting bacterial infections at different levels of TBIL were 0.907 (95% CI 0.828-0.958) and 0.38 ng/mL, respectively, for TBIL PCT was a valuable marker of bacterial infection in patients with chronic liver diseases. TBIL affected PCT threshold, so different cut-offs should be used according to different TBIL values. PMID:27472699

  14. Clinical Usefulness of Procalcitonin and C-Reactive Protein as Outcome Predictors in Critically Ill Patients with Severe Sepsis and Septic Shock.

    Jeong-Am Ryu

    Full Text Available Sepsis is a major cause of mortality and morbidity in critically ill patients. Procalcitonin (PCT and C-reactive protein (CRP are the most frequently used biomarkers in sepsis. We investigated changes in PCT and CRP concentrations in critically ill patients with sepsis to determine which biochemical marker better predicts outcome. We retrospectively analyzed 171 episodes in 157 patients with severe sepsis and septic shock who were admitted to the Samsung Medical Center intensive care unit from March 2013 to February 2014. The primary endpoint was patient outcome within 7 days from ICU admission (treatment failure. The secondary endpoint was 28-day mortality. Severe sepsis was observed in 42 (25% episodes from 41 patients, and septic shock was observed in 129 (75% episodes from 120 patients. Fifty-five (32% episodes from 42 patients had clinically-documented infection, and 116 (68% episodes from 99 patients had microbiologically-documented infection. Initial peak PCT and CRP levels were not associated with treatment failure and 28-day mortality. However, PCT clearance (PCTc and CRP (CRPc clearance were significantly associated with treatment failure (p = 0.027 and p = 0.030, respectively and marginally significant with 28-day mortality (p = 0.064 and p = 0.062, respectively. The AUC for prediction of treatment success was 0.71 (95% CI, 0.61-0.82 for PCTc and 0.71 (95% CI, 0.61-0.81 for CRPc. The AUC for survival prediction was 0.77 (95% CI, 0.66-0.88 for PCTc and 0.77 (95% CI, 0.67-0.88 for CRPc. Changes in PCT and CRP concentrations were associated with outcomes of critically ill septic patients. CRP may not be inferior to PCT in predicting outcome in these patients.

  15. Adults with Chromosome 18 Abnormalities.

    Soileau, Bridgette; Hasi, Minire; Sebold, Courtney; Hill, Annice; O'Donnell, Louise; Hale, Daniel E; Cody, Jannine D

    2015-08-01

    The identification of an underlying chromosome abnormality frequently marks the endpoint of a diagnostic odyssey. However, families are frequently left with more questions than answers as they consider their child's future. In the case of rare chromosome conditions, a lack of longitudinal data often makes it difficult to provide anticipatory guidance to these families. The objective of this study is to describe the lifespan, educational attainment, living situation, and behavioral phenotype of adults with chromosome 18 abnormalities. The Chromosome 18 Clinical Research Center has enrolled 483 individuals with one of the following conditions: 18q-, 18p-, Tetrasomy 18p, and Ring 18. As a part of the ongoing longitudinal study, we collect data on living arrangements, educational level attained, and employment status as well as data on executive functioning and behavioral skills on an annual basis. Within our cohort, 28 of the 483 participants have died, the majority of whom have deletions encompassing the TCF4 gene or who have unbalanced rearrangement involving other chromosomes. Data regarding the cause of and age at death are presented. We also report on the living situation, educational attainment, and behavioral phenotype of the 151 participants over the age of 18. In general, educational level is higher for people with all these conditions than implied by the early literature, including some that received post-high school education. In addition, some individuals are able to live independently, though at this point they represent a minority of patients. Data on executive function and behavioral phenotype are also presented. Taken together, these data provide insight into the long-term outcome for individuals with a chromosome 18 condition. This information is critical in counseling families on the range of potential outcomes for their child. PMID:25403900

  16. Sensory Abnormalities in Autism: A Brief Report

    Klintwall Lars; Holm, Anette; Eriksson, Mats; Carlsson, Lotta Hoglund; Olsson, Martina Barnevik; Hedvall, Asa; Gillberg, Christopher; Fernell, Elisabeth

    2011-01-01

    Sensory abnormalities were assessed in a population-based group of 208 20-54-month-old children, diagnosed with autism spectrum disorder (ASD) and referred to a specialized habilitation centre for early intervention. The children were subgrouped based upon degree of autistic symptoms and cognitive level by a research team at the centre. Parents…

  17. Diagnosis of regional cerebral blood flow abnormalities using SPECT: agreement between individualized statistical parametric maps and visual inspection by nuclear medicine physicians with different levels of expertise in nuclear neurology

    Introduction: visual analysis is widely used to interpret regional cerebral blood flow (rCBF) SPECT images in clinical practice despite its limitations. Automated methods are employed to investigate between-group rCBF differences in research studies but have rarely been explored in individual analyses. Objectives: to compare visual inspection by nuclear physicians with the automated statistical parametric mapping program using a SPECT dataset of patients with neurological disorders and normal control images. Methods: using statistical parametric mapping, 14 SPECT images from patients with various neurological disorders were compared individually with a databank of 32 normal images using a statistical threshold of p<0.05 (corrected for multiple comparisons at the level of individual voxels or clusters). Statistical parametric mapping results were compared with visual analyses by a nuclear physician highly experienced in neurology (A) as well as a nuclear physician with a general background of experience (B) who independently classified images as normal or altered, and determined the location of changes and the severity. Results: of the 32 images of the normal databank, 4 generated maps showing rCBF abnormalities (p<0.05, corrected). Among the 14 images from patients with neurological disorders, 13 showed rCBF alterations. Statistical parametric mapping and physician A completely agreed on 84.37% and 64.28% of cases from the normal databank and neurological disorders, respectively. The agreement between statistical parametric mapping and ratings of physician B were lower (71.18% and 35.71%, respectively). Conclusion: statistical parametric mapping replicated the findings described by the more experienced nuclear physician. This finding suggests that automated methods for individually analyzing rCBF SPECT images may be a valuable resource to complement visual inspection in clinical practice. (author)

  18. Influence of procalcitonin and C-reactive protein on prognosis of patients with postoperative severe sepsis%降钙素原与 C-反应蛋白对术后重度脓毒血症患者预后的影响

    龙涛; 白蓉蓉; 李智; 黄磊; 王雪

    2015-01-01

    OBJECTIVE To explore the influence of procalcitonin and C‐reactive protein on the prognosis of the pa‐tients with postoperative sepsis and observe the association with the prognosis of the sepsis patients .METHODS A total of 60 patients with postoperative sepsis who underwent the thoracic or abdominal surgery from Aug 2012 to Aug 2013 were randomly enrolled in the study ,totally 54 cases were included ,6 cases were not eligible for the study and excluded .The blood specimens were extracted from the patients with severe sepsis on day 1 ,2 ,3 ,5 , 7 ,and 10 after the experiment ;the inflammatory indicators including the procalcitonin and C‐reactive protein were detected ,and the results of the experiments were recorded and analyzed .RESULTS There was no significant differ‐ence in the procalcitonin ,C‐reactive protein ,or APACHEⅡ score among the patients with various prognosis in the first three days after the experiment ;there was significant difference in the procalcitonin ,C‐reactive protein , or APACHEⅡ score among the patients with various prognosis on day 7 and 10 after the experiment (P<0 .05) . The area under curve (AUC) for prognosis evaluation of the sepsis patients within 4 weeks after the experiments relative to the procalcitonin ,C‐reactive protein ,and APACHEⅡ score on day 7 were as follows :the procalcitonin 0 .689 ,the C‐reactive protein 0 .691 ,the APACHEⅡ score 0 .651 .CONCLUSION The change of disease of the pa‐tients with postoperative severe sepsis is highly associated with the levels of procalcitonin and C‐reactive protein on day 7 ,therefore ,the joint detection of procalcitonin with C‐reactive protein plays an important role in the prognos‐tic diagnosis of the patients with postoperative severe sepsis ,and it is worthy to be promoted in the hospital .%目的:探讨检测降钙素原以及C‐反应蛋白对于手术后脓毒血症患者的预后影响,判断其在脓毒血症患者预后的

  19. Dopaminergic system abnormalities Etiopathogenesis of dystonia

    Shuhui Wu; Huifang Shang; Xiaoyi Zou

    2008-01-01

    etiopathogenesis of several primary dystonias has been observed at the molecular level. CONCLUSION: Various abnormalities of the dopaminergic system exist for different forms of dystonia; therefore, much more research is needed in this area. At the molecular level, relationships between abnormalities of the dopaminergic system and etiopathogenesis of the following syndromes have been observed: dopa-responsive dystonia, early-onset torsion dystonia, X-linked dystonia-parkinsonism syndrome, myoclonus dystonia syndrome, primary cervical dystonia, and focal dystonia blepharospasm.

  20. Serum procalcitonin for the early recognition of nosocomial infection in the critically ill patients: a preliminary report

    Olsson Nils-Olivier

    2009-04-01

    Full Text Available Abstract Background The usefulness of procalcitonin (PCT measurement in critically ill medical patients with suspected nosocomial infection is unclear. The aim of the study was to assess PCT value for the early diagnosis of bacterial nosocomial infection in selected critically ill patients. Methods An observational cohort study in a 15-bed intensive care unit was performed. Seventy patients with either proven (n = 47 or clinically suspected but not confirmed (n = 23 nosocomial infection were included. Procalcitonin measurements were obtained the day when the infection was suspected (D0 and at least one time within the 3 previous days (D-3 to D0. Patients with proven infection were compared to those without. The diagnostic value of PCT on D0 was determined through the construction of the corresponding receiver operating characteristic (ROC curve. In addition, the predictive value of PCT variations preceding the clinical suspicion of infection was assessed. Results PCT on D0 was the best predictor of proven infection in this population of ICU patients with a clinical suspicion of infection (AUROCC = 0.80; 95% CI, 0.68–0.91. Thus, a cut-off value of 0.44 ng/mL provides sensitivity and specificity of 65.2% and 83.0%, respectively. Procalcitonin variation between D-1 and D0 was calculated in 45 patients and was also found to be predictive of nosocomial infection (AUROCC = 0.89; 95% CI, 0.79–0.98 with a 100% positive predictive value if the +0.26 ng/mL threshold value was applied. Comparable results were obtained when PCT variation between D-2 and D0, or D-3 and D0 were considered. In contrast, CRP elevation, leukocyte count and fever had a poor predictive value in our population. Conclusion PCT monitoring could be helpful in the early diagnosis of nosocomial infection in the ICU. Both absolute values and variations should be considered and evaluated in further studies.

  1. Procalcitonin is not sufficiently reliable to be the sole marker of neonatal sepsis of nosocomial origin

    López Sastre, José B; Pérez Solís, David; Roqués Serradilla, Vicente; Fernández Colomer, Belén; Coto Cotallo, Gil D; Krauel Vidal, Xavier; Narbona López, Eduardo; García del Río, Manuel; Sánchez Luna, Manuel; Belaustegui Cueto, Antonio; Moro Serrano, Manuel; Urbón Artero, Alfonso; Álvaro Iglesias, Emilio; Cotero Lavín, Ángel; Martínez Vilalta, Eduardo; Jiménez Cobos, Bartolomé

    2006-01-01

    Background It has recently been suggested that serum procalcitonin (PCT) is of value in the diagnosis of neonatal sepsis, with varying results. The aim of this prospective multicenter study was to assess the usefulness of PCT as a marker of neonatal sepsis of nosocomial origin. Methods One hundred infants aged between 4 and 28 days of life admitted to the Neonatology Services of 13 acute-care teaching hospitals in Spain over 1-year with clinical suspicion of neonatal sepsis of nosocomial origin were included in the study. Serum PCT concentrations were determined by a specific immunoluminometric assay. The reliability of PCT for the diagnosis of nosocomial neonatal sepsis at the time of suspicion of infection and at 12–24 h and 36–48 h after the onset of symptoms was calculated by receiver-operating characteristics (ROC) curves. The Youden's index (sensitivity + specificity - 1) was used for determination of optimal cutoff values of the diagnostic tests in the different postnatal periods. Sensitivity, specificity, and the likelihood ratio of a positive and negative result with the 95% confidence interval (CI) were calculated. Results The diagnosis of nosocomial sepsis was confirmed in 61 neonates. Serum PCT concentrations were significantly higher at initial suspicion and at 12–24 h and 36–48 h after the onset of symptoms in neonates with confirmed sepsis than in neonates with clinically suspected but not confirmed sepsis. Optimal PCT thresholds according to ROC curves were 0.59 ng/mL at the time of suspicion of sepsis (sensitivity 81.4%, specificity 80.6%); 1.34 ng/mL within 12–24 h of birth (sensitivity 73.7%, specificity 80.6%), and 0.69 ng/mL within 36–48 h of birth (sensitivity 86.5%, specificity 72.7%). Conclusion Serum PCT concentrations showed a moderate diagnostic reliability for the detection of nosocomial neonatal sepsis from the time of suspicion of infection. PCT is not sufficiently reliable to be the sole marker of sepsis, but would be

  2. Efficacy and Safety of Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infections

    Werner C. Albrich

    2013-01-01

    Full Text Available Background: In 14 randomized controlled studies to date, a procalcitonin (PCT-based algorithm has been proven to markedly reduce the use of antibiotics along with an unimpaired high safety and low complication rates in patients with lower respiratory tract infections (LRTIs. However, compliance with the algorithm and safety out of controlled study conditions has not yet been sufficiently investigated. Methods: We performed a prospective international multicenter observational post-study surveillance of consecutive adults with community-acquired LRTI in 14 centers (Switzerland (n = 10, France (n = 3 and the United States (n = 1. Results: Between September 2009 and November 2010, 1,759 patients were enrolled (median age 71; female sex 44.4%. 1,520 (86.4% patients had a final diagnosis of LRTI (community-acquired pneumonia (CAP, 53.7%; acute exacerbation of chronic obstructive pulmonary disease (AECOPD, 17.1%; and acute bronchitis, 14.4%. Compliance with the PCT-guided therapy (overall 68.2% was highest in patients with bronchitis (81.0% vs. AECOPD, 70.1%; CAP, 63.7%; p < 0.001, outpatients (86.1% vs. inpatients, 65.9%; p < 0.001 and algorithm-experienced centers (82.5% vs. algorithm-naive, 60.1%; p < 0.001 and showed significant geographical differences. The initial decision about the antibiotic therapy was based on PCT value in 72.4%. In another 8.6% of patients, antibiotics were administered despite low PCT values but according to predefined criteria. Thus, the algorithm was followed in 81.0% of patients. In a multivariable Cox hazard ratio model, longer antibiotic therapy duration was associated with algorithm-non-compliance, country, hospitalization, CAP vs. bronchitis, renal failure and algorithm-naïvety of the study center. In a multivariable logistic regression complications (death, empyema, ICU treatment, mechanical ventilation, relapse, and antibiotic-associated side effects were significantly associated with increasing CURB65-Score, CAP

  3. Stop Antibiotics on guidance of Procalcitonin Study (SAPS) : a randomised prospective multicenter investigator-initiated trial to analyse whether daily measurements of procalcitonin versus a standard-of-care approach can safely shorten antibiotic duration in intensive care unit patients - calculated sample size: 1816 patients

    Assink-de Jong, Evelien; de lange, Dylan W.; van Oers, Jos A.; Nijsten, Maarten W.; Twisk, Jos W.; Beishuizen, Albertus

    2013-01-01

    Background: Unnecessary long-term use of broad-spectrum antibiotics is linked to the emergence and selection of resistant bacteria, prolonged hospitalisation and increased costs. Several clinical trials indicate that the biomarker procalcitonin (PCT) can guide antibiotic therapy. Some of these trial

  4. Procalcitonin Is a Stronger Predictor of Long-Term Functional Outcome and Mortality than High-Sensitivity C-Reactive Protein in Patients with Ischemic Stroke.

    Wang, Chao; Gao, Li; Zhang, Zhi-Guo; Li, Yu-Qian; Yang, Yan-Long; Chang, Tao; Zheng, Long-Long; Zhang, Xing-Ye; Man, Ming-Hao; Li, Li-Hong

    2016-04-01

    Inflammatory markers have been associated with functional outcome and mortality of stroke. We investigated the changes in procalcitonin (PCT) and high-sensitivity C-reactive protein (Hs-CRP) levels during the acute period of ischemic stroke and evaluated the relationship between these levels and the long-term functional outcome and mortality. We prospectively studied 376 patients with acute ischemic stroke (AIS) who were admitted within 24 h after the onset of symptoms. PCT, Hs-CRP, and NIH Stroke Scale (NIHSS) were measured at the time of admission. Long-term functional outcome were measured by modified Rankin scale (mRS) at 1 year after admission. The correlations between the levels of PCT, Hs-CRP, and mortality at 1 year after stroke onset were analyzed. Patients with poor with functional outcome and non-survivors had significantly increased PCT and Hs-CRP levels on admission. Multivariate logistic regression analysis showed that PCT was an independent prognostic marker of 1-year functional outcome and death [odds ratio (OR) 2.33 (95% CI, 1.33-3.44) and 3.11 (2.02-4.43), respectively, P < 0.0001 for both, adjusted for age, NIHSS, other predictors, and vascular risk factors] in patients with AIS. The area under the receiver operating characteristic curve of PCT was 0.77 (95% CI, 0.72-0.83) for functional outcome and 0.88 (95% CI, 0.84-0.93) for mortality. PCT improved the area under the receiver operating characteristic curve of the NIHSS score for functional outcome from 0.74 (95% CI, 0.66-0.81) to 0.85 (95% CI, 0.76-0.92; P < 0.0001) and for mortality from 0.77 (95% CI, 0.70-0.83) to 0.94 (95% CI, 0.89-0.97; P < 0.0001). Serum level of PCT at admission was an independent predictor of long-term functional outcome and mortality after ischemic stroke in Chinese sample. PMID:25650122

  5. Behavioral abnormalities in captive nonhuman primates.

    Mallapur, Avanti; Choudhury, B C

    2003-01-01

    In this study, we dealt with 11 species of nonhuman primates across 10 zoos in India. We recorded behavior as instantaneous scans between 9 a.m. and 5 p.m. In the study, we segregated behaviors for analyses into abnormal, undesirable, active, and resting. The 4 types of abnormal behavior exhibited included floating limb, self-biting, self-clasping, and stereotypic pacing. In the study, we recorded 2 types of undesirable behavior: autoerotic stimulation and begging. Langurs and group-housed macaques did not exhibit undesirable behaviors. A male lion-tailed macaque and a male gibbon exhibited begging behavior. autoerotic stimulation and self-biting occurred rarely. Males exhibited higher levels of undesirable behavior than did females. Animals confiscated from touring zoos, circuses, and animal traders exhibited higher levels of abnormal behaviors than did animals reared in larger, recognized zoos. The stump-tailed macaque was the only species to exhibit floating limb, autoerotic stimulation, self-biting, and self-clasping. Our results show that rearing experience and group composition influence the proportions of abnormal behavior exhibited by nonhuman primates in captivity. The history of early social and environmental deprivation in these species of captive nonhuman primates probably is critical in the development of behavioral pathologies. Establishing this will require further research. PMID:14965782

  6. Progression on the detection of procalcitonin and its clinical application%降钙素原的测定与临床应用进展

    张代民

    2007-01-01

    降钙素原(Procalcitonin,PCT)是降钙素的前体物质,作为一种炎症介质,近年来成为鉴别严重细菌感染的新型标志物.本文就PCT的来源、代谢、实验室检测方法及临床应用作一综述.

  7. Applications of Procalcitonin in Peritoneal Dialysis Related Peritonitis%降钙素原在腹膜透析相关性腹膜炎中的应用

    朱琳(综述); 解汝娟(审校)

    2015-01-01

    降钙素原是一种炎症标志物,其在多种临床感染性疾病中均显示出高度的特异性及敏感性。鉴于传统的腹膜透析相关性腹膜炎的检测手段均具有一定的局限性,国内外学者开始倾向于将降钙素原纳入腹膜透析相关性腹膜炎的诊断指标,研究表明腹膜透析相关性腹膜炎患者的血清降钙素原水平显著升高。因此,降钙素原可以作为腹膜透析相关性腹膜炎患者在诊断和治疗过程中的重要检测指标,其对腹膜透析相关性腹膜炎的指导意义值得进一步探索。%Procalcitonin has been clearly specified as an infection marker for many clinical diagnosis of bacterial infections with high sensitivity and specificity .In view of some certain limitations on traditional diag-nostic standards of peritoneal dialysis related peritonitis, both domestic and foreign scholars tended to intro-duce procalcitonin as one of peritoneal dialysis related peritonitis indicators .A large number of studies showed that patients suffering from peritoneal dialysis related peritonitis gained significantly higher concentra-tion of serum procalcitonin.Therefore, procalcitonin can be used as an important detection index in the diag-nosis and treatment of peritoneal dialysis related peritonitis,the guiding significance of which deserves further exploration.

  8. Hubungan antara Leukosit dengan Procalcitonin sebagai Biomarker Sepsis di Rumah Sakit Umum Pusat Haji Adam Malik Bulan Agustus – Oktober 2015 Medan

    Octavia, Sherly

    2016-01-01

    Introduction: Sepsis is a systemic response to infection with clinic manifestation of fever, tachycardia, tachypnea, leukocytosis or leukopenia and local infection. Sepsis is still the main cause of mortality in critical care case in many countries. The high incidence and infection problems usually indicated in developing countries or places with poor hygiene. Lately a new diagnostic test is being known as procalcitonin (PCT) in which is a “gold standard” in sepsis case. PCT te...

  9. Prospective Evaluation of Procalcitonin, Soluble Triggering Receptor Expressed on Myeloid Cells-1 and C-Reactive Protein in Febrile Patients with Autoimmune Diseases

    Lin, Chou-Han; Hsieh, Song-Chou; Keng, Li-Ta; Lee, Ho-Sheng; Chang, Hou-Tai; Liao, Wei-Yu; Ho, Chao-Chi; Yu, Chong-Jen

    2016-01-01

    Background Both procalcitonin (PCT) and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) have been investigated separately as indicators of infection in patients with autoimmune diseases. Our study simultaneously evaluated both PCT and sTREM-1 along with C-reactive protein (CRP) in febrile patients with autoimmune diseases. Methods Fifty-nine patients were enrolled in the study. The patients were categorized into the infection group (n = 24) or the disease flare group (n = 3...

  10. Higher diagnostic accuracy and cost-effectiveness using procalcitonin in the treatment of emergency medicine patients with fever (The HiTEMP study): a multicenter randomized study

    van der Does, Yuri; Limper, Maarten; Schuit, Stephanie C. E.; Poley, Marten J.; Rosmalen, Joost; Ramakers, Christian; Patka, Peter; van Gorp, Eric C. M.; Rood, Pleunie P. M.

    2016-01-01

    Background Fever is a common symptom in the emergency department(ED). Fever can be caused by bacterial infections, which are treated with antibiotics. Often, bacterial infections cannot be ruled out in the ED using standard diagnostics, and empiric antibiotic treatment is started. Procalcitonin(PCT) is a biomarker for bacterial infections, but its role in an undifferentiated ED population remains unclear. We hypothesize that PCT-guided therapy may reduce antibiotics prescription in undifferen...

  11. Nilai Diagnostik Dan Korelasi Rasio Neutrofil-Limfosit Dengan Serum Procalcitonin Sebagai Biomarker Infeksi Bakteri Pasien Sepsis Di Rumah Sakit Umum Pusat Adam Malik

    Raja, David Marintua

    2016-01-01

    Background: Prevention for bacterial sepsis complications include early identification, source control and antibiotic treatment. Identification through an ideal biomarker; inexpensive, easy to do and interpret, available in any healthcare facility. Neutrophyl Lymphocyte count ratio (NLCR) is a new promising clinical biomarker being studied, beside of serum procalcitonin as gold standard of bacterial infection diagnostic biomarker. Method: This research is a diagnostic test, cross-sectional...

  12. The association of serum procalcitonin and high-sensitivity C-reactive protein with pneumonia in elderly multimorbid patients with respiratory symptoms: retrospective cohort study

    Nouvenne, Antonio; Ticinesi, Andrea; Folesani, Giuseppina; Cerundolo, Nicoletta; Prati, Beatrice; Morelli, Ilaria; Guida, Loredana; Lauretani, Fulvio; Maggio, Marcello; Aloe, Rosalia; Lippi, Giuseppe; Meschi, Tiziana

    2016-01-01

    Background Serum procalcitonin and high-sensitivity C-reactive protein (hs-CRP) elevations have been associated with pneumonia in adults. Our aim was to establish their diagnostic usefulness in a cohort of hospitalized multimorbid patients ≥65 years old admitted to hospital with acute respiratory symptoms. Methods With a retrospective cohort study design, all multimorbid patients ≥65 years-old with acute respiratory symptoms admitted to an internal medicine hospital ward in Italy from January...

  13. Combination of C-reactive protein, procalcitonin and sepsis-related organ failure score for the diagnosis of sepsis in critical patients

    Yi YANG; Xie, Jianfeng; Guo, Fengmei; Longhini, Federico; Gao, Zhiwei; Huang, Yingzi; Qiu, Haibo

    2016-01-01

    Objective To measure the ability of a new bioscore to diagnose sepsis in a general critical care population. Methods The study was done at an intensive care unit (ICU) from April to December 2012. Demographic and clinical patient information were recorded on admission to the ICU with blood samples taken for C-reactive protein (CRP), procalcitonin (PCT), interleukin-6, white blood cell count, as well as body temperature, age and the sepsis-related organ failure (SOFA) score. These parameters w...

  14. Systemic abnormalities in liver disease

    Minemura, Masami; Tajiri, Kazuto; Shimizu, Yukihiro

    2009-01-01

    Systemic abnormalities often occur in patients with liver disease. In particular, cardiopulmonary or renal diseases accompanied by advanced liver disease can be serious and may determine the quality of life and prognosis of patients. Therefore, both hepatologists and non-hepatologists should pay attention to such abnormalities in the management of patients with liver diseases.

  15. Spinal cord injury without radiographic abnormality

    Singh Anil

    2006-01-01

    Full Text Available Spinal cord injury without radiological abnormality is rare in adults. Below we present a case report of 20 yrs old male with isolated cervical cord injury, without accompanying vertebral dislocation or fracture involving the spinal canal rim. He fell down on plain and smooth ground while carrying 40 kg weight overhead and developed quadriparesis with difficulty in respiration. Plain radiographs of the neck revealed no fractures or dislocations. MRI showed bulky spinal cord and an abnormal hyper intense signal on the T2W image from C2 vertebral body level to C3/4 intervertebral disc level predominantly in the anterior aspect of the cord The patient was managed conservatively with head halter traction and invasive ventilatory support for the initial 7 days period in the ICU. In our patient recovery was good and most of the neurological deficit improved over 4 weeks with conservative management.

  16. Skin - abnormally dark or light

    ... ency/article/003242.htm Skin - abnormally dark or light To use the sharing features on this page, ... the hands. The bronze color can range from light to dark (in fair-skinned people) with the ...

  17. A composite score combining procalcitonin, C-reactive protein and temperature has a high positive predictive value for the diagnosis of intensive care-acquired infections

    2013-01-01

    Background Nosocomial infection diagnosis in the intensive care unit (ICU) remains a challenge. We compared routine measurements of procalcitonin (PCT), C-reactive protein (CRP), white blood cell count (WBC) and temperature in the detection of ICU-acquired infections. Method Prospective observational cohort study in a University hospital Medicosurgical ICU. All patients admitted to the ICU ≥ 5 days (n = 141) were included into two groups, either infected (documented infection, n = 25) or non-infected (discharged from the ICU without diagnosis of infection, n = 88). Results PCT, CRP, WBC and temperature progression from day −4 (D-4) to day 0 (D0) (day of infection diagnosis or ICU discharge) was analysed. Differences (Δ) were calculated as D0 levels minus the lowest preceding value. D0 PCT and CRP were significantly increased in infected compared to non-infected patients (median, 1st and 3rd quartiles): 3.6 ng/mL (0.92-25) for PCT, 173 mg/L (126–188) for CRP versus 0.02 ng/mL (0.1-0.9) and 57 mg/mL (31–105) respectively (p  38.6°C, PCT > 1.86 ng/mL, and CRP > 88 mg/L, performed well (AUCs of 0.88, 0.84, and 0.88 respectively). The sensitivity/specificity profiles of each marker (76%/94% for temperature, 68%/91% for PCT, and 92%/70% for CRP) led to a composite score (0.068 × D0 PCT + 0.005 × D0 CRP + 0.7 × temperature) more highly specific than each component (AUC of 0.90 and sensitivity/specificity of 80%/97%). Conclusion Combining CRP, PCT and temperature is an approach which may increase of nosocomial infection detection in the ICU. PMID:23547830

  18. 降钙素原在儿科感染性疾病诊断中的应用%Procalcitonin in diagnosis of pediatric infectious diseases

    王耀华

    2011-01-01

    Objective To investigate the clinical significance of the application of procalcitonin (PCT) in the diagnosis of pediatric infectious diseases. Methods Semi -quantitative serum immune chromatography 120 cases and 40 healthy children, children with PCT levels, 120 patients were divided into groups of local infection in 50 cases, 40 cases of severe infection and viral infection, 30 patients , a comparative analysis of each group measurement results and the positive rate, for statistical a-nalysis. Results Severe infection and local infection group, the difference was significant (P < 0.01); severe infection and viral infection group, the difference was significant (P <0. 01); severe infection with the healthy group, the differences were statistically significance (P <0. 01). Conclusions PCT help clinicians to identify local mild infection and severe systemic infections, viral infections and bacterial infections and tuberculosis, non - infectious diseases and infectious diseases, which can be used as pediatric sepsis and severe infection, an important indicator and diagnostic parameters, index and disease severity.%目的 探讨降钙素原在儿科感染性疾病诊断中应用的临床意义.方法 采用血清半定量免疫色谱法测定120例患儿和40例健康儿童PCT水平,120例患儿分为局部感染组50例,重症感染组40例和病毒感染组30例,比较分析各组测定结果和阳性率,进行统计学分析.结果 重症感染与局部感染组比较,差异有显著性(P<0.01);重症感染与病毒感染组比较,差异有显著性(P<0.01);重症感染与健康组比较,差异均有统计学意义(P<0.01).结论 PCT有助于临床鉴别全身重症感染与局部轻症感染、病毒及结核感染与细菌感染、非感染性疾病与感染性疾病,其也可作为儿科败血症及严重感染时一个重要指标和诊断参数,指标与病情严重程度相关.

  19. Salivary and serum procalcitonin and C-reactive protein as biomarkers of periodontitis in United States veterans with osteoarthritis or rheumatoid arthritis.

    Redman, R S; Kerr, G S; Payne, J B; Mikuls, T R; Huang, J; Sayles, H R; Becker, K L; Nylén, E S

    2016-01-01

    Serum procalcitonin (ProCT) is elevated in response to bacterial infections, whereas high sensitivity C-reactive protein (hsCRP) is a nonspecific inflammatory marker that is increased by excess adipose tissue. We examined the efficacy of ProCT and hsCRP as biomarkers of periodontitis in the saliva and serum of patients with arthritis, which is characterized by variable levels of systemic inflammation that potentially can confound the interpretation of inflammatory biomarkers. Blood and unstimulated whole saliva were collected from 33 patients with rheumatoid arthritis (RA) and 50 with osteoarthritis (OA). Periodontal status was assessed by full mouth examination and patients were categorized as having no/mild, moderate or severe periodontitis by standard parameters. Salivary and serum ProCT and hsCRP concentrations were compared. BMI, diabetes, anti-inflammatory medications and smoking status were ascertained from the patient records. Differences between OA and RA in proportionate numbers of patients were compared for race, gender, diabetes, adiposity and smoking status. Serum ProCT was significantly higher in arthritis patients with moderate to severe and severe periodontitis compared with no/mild periodontitis patients. There were no significant differences in salivary ProCT or salivary or serum hsCRP in RA patients related to periodontitis category. Most of the OA and RA patients were middle aged or older, 28.9% were diabetic, 78.3% were overweight or obese, and slightly more than half were either current or past smokers. The OA and RA groups differed by race, but not gender; blacks and males were predominant in both groups. The OA and RA groups did not differ in terms of controlled or uncontrolled diabetes, smoking status or BMI. The RA patients had been prescribed more anti-inflammatory medication than the OA patients. Our results demonstrate that circulating ProCT is a more discriminative biomarker for periodontitis than serum hsCRP in patients with

  20. Memetics clarification of abnormal behavior

    2007-01-01

    AIM: Biological medicine is hard to fully and scientifically explain the etiological factor and pathogenesis of abnormal behaviors; while, researches on philosophy and psychology (including memetics) are beneficial to better understand and explain etiological factor and pathogenesis of abnormal behaviors. At present, the theory of philosophy and psychology is to investigate the entity of abnormal behavior based on the views of memetics.METHODS: Abnormal behavior was researched in this study based on three aspects, including instinctive behavior disorder, poorly social-adapted behavior disorder and mental or body disease associated behavior disorder. Most main viewpoints of memetics were derived from "The Meme Machine", which was written by Susan Blackmore. When questions about abnormal behaviors induced by mental and psychological diseases and conduct disorder of teenagers were discussed, some researching achievements which were summarized by authors previously were added in this study, such as aggressive behaviors, pathologically aggressive behaviors, etc.RESULTS: The abnormal behaviors mainly referred to a part of people's substandard behaviors which were not according with the realistic social environment, culture background and the pathologic behaviors resulted from people's various psychological diseases. According to the theory of "meme", it demonstrated that the relevant behavioral obstacles of various psychological diseases, for example, the unusual behavior of schizophrenia, were caused, because the old meme was destroyed thoroughly but the new meme was unable to establish; psychoneurosis and personality disorder were resulted in hard establishment of meme; the behavioral obstacles which were ill-adapted to society, for example, various additional and homosexual behaviors, were because of the selfish replications and imitations of "additional meme" and "homosexual meme"; various instinct behavioral and congenital intelligent obstacles were not significance

  1. Thyroid abnormality in perimenopausal women with abnormal uterine bleeding

    Prasanna Byna

    2015-11-01

    Full Text Available Background: AUB is a common but complicated clinical presentation and occurs in 15-20% of women between menarche to menopause and significantly affects the women's health. Women with thyroid dysfunction often have menstrual irregularities, infertility and increased morbidity during pregnancy. The objective of present study is to find the correlation between thyroid disorders and AUB in perimenopausal women attending gynecology OPD. Methods: In the present study, fifty five patients with AUB were included and were evaluated for the cause including thyroid abnormality. Thyroid function tests were done in all patients. Results: Among 55 patients, 12 patients were diagnosed as hypothyroidism and 7 as hyperthyroidism, women with AUB 36 (65.4% were euthyroid. Among 19 women with thyroid abnormality, heavy menstrual bleeding was seen in 8 (42% women, 6 (31.57% had polymenorrhagia, 5 (26.31% had oligomenorrhoea. The frequent menstrual abnormality in women with hypothyroidism (12 women was heavy menstrual bleeding in 5 (41.6% women, 3 (25% had oligomennorhoea, 4 (33.3% had polymenorrhagia. Out of 7 women with hyperthyroidism, 2 (28.57% had oligomenorrhoea, 3 (42.8% had heavy menstrual bleeding, 2 (28.57% had polymenorrhagia. In a total of 55 patients with AUB, 11 (20% had structural abnormalities in uterus and ovaries. 5 (9% had adenomyosis, 3 (5.4% had ovarian cysts, 3 (5.4% had fibroids. Conclusions: It is important to screen all women for thyroid abnormality who are presenting with AUB especially with non-structural causes of AUB. Correction of thyroid abnormalities also relieves AUB. This will avoid unnecessary hormonal treatment and surgery. [Int J Res Med Sci 2015; 3(11.000: 3250-3253

  2. Management of abnormal radioactive wastes at nuclear power plants

    As with any other industrial activity, a certain level of risk is associated with the operation of nuclear power plants and other nuclear facilities. That is, on occasions nuclear power plants or nuclear facilities may operate under conditions which were not specifically anticipated during the design and construction of the plant. These abnormal conditions and situations may cause the production of abnormal waste, which can differ in character or quantity from waste produced during normal routine operation of nuclear facilities. Abnormal waste can also occur during decontamination programmes, replacement of a reactor component, de-sludging of storage ponds, etc. The management of such kinds of waste involves the need to evaluate existing waste management systems in order to determine how abnormal wastes should best be handled and processed. There are no known publications on this subject, and the IAEA believes that the development and exchange of such information among its Member States would be useful for specialists working in the waste management area. The main objective of this report is to review existing waste management practices which can be applied to abnormal waste and provide assistance in the selection of appropriate technologies and processes that can be used when abnormal situations occur. Naturally, the subject of abnormal waste is complex and this report can only be considered as a guide for the management of abnormal waste. Refs, figs and tabs.

  3. Abnormal Cervical Cancer Screening Test Results

    ... AQ FREQUENTLY ASKED QUESTIONS FAQ187 GYNECOLOGIC PROBLEMS Abnormal Cervical Cancer Screening Test Results • What is cervical cancer screening? • What causes abnormal cervical cancer screening test ...

  4. Neuroimaging abnormalities in Griscelli's disease

    Griscelli's disease is a rare autosomal recessive immunodeficiency syndrome. We report a 7-1/2-month-old white girl who presented with this syndrome, but initially without neurological abnormalities. Initial CT of the brain was normal. Despite haematological remission with chemotherapy, she developed neurological symptoms, progressing to coma. At this time, CT showed areas of coarse calcification in the globi pallidi, left parietal white matter and left brachium pontis. Hypodense areas were present in the genu and posterior limb of the internal capsule on the right side, as well as posterior aspects of both thalami, together with minimal generalised atrophy. MRI revealed areas of increased T2 signal and a focal area of abnormal enhancement in the subcortical white matter. Griscelli's disease should be added to the list of acquired neuroimaging abnormalities in infants. (orig.)

  5. Knee loading for abnormal gait

    Hutchison, J.; Madsen, D.; Norman, T. L.; -Blaha, J. D.

    2014-01-01

    The purpose of the study was to develop a mathematical model for determining knee loads for abnormal gait. Abnormal gait was defined as a person with varus, i.e. “bowleggedness”, or a person who had an external rotation of the femur (or the inability to internally rotate the femur) which caused an indirect varus in the forward positions of gait. Conditions such as these have been observed clinically to result in increased wear on the medial condyle of total knee replacements. This problem was...

  6. Procalcitonin Improves the Glasgow Prognostic Score for Outcome Prediction in Emergency Patients with Cancer: A Cohort Study

    Anna Christina Rast

    2015-01-01

    Full Text Available The Glasgow Prognostic Score (GPS is useful for predicting long-term mortality in cancer patients. Our aim was to validate the GPS in ED patients with different cancer-related urgency and investigate whether biomarkers would improve its accuracy. We followed consecutive medical patients presenting with a cancer-related medical urgency to a tertiary care hospital in Switzerland. Upon admission, we measured procalcitonin (PCT, white blood cell count, urea, 25-hydroxyvitamin D, corrected calcium, C-reactive protein, and albumin and calculated the GPS. Of 341 included patients (median age 68 years, 61% males, 81 (23.8% died within 30 days after admission. The GPS showed moderate prognostic accuracy (AUC 0.67 for mortality. Among the different biomarkers, PCT provided the highest prognostic accuracy (odds ratio 1.6 (95% confidence interval 1.3 to 1.9, P<0.001, AUC 0.69 and significantly improved the GPS to a combined AUC of 0.74 (P=0.007. Considering all investigated biomarkers, the AUC increased to 0.76 (P<0.001. The GPS performance was significantly improved by the addition of PCT and other biomarkers for risk stratification in ED cancer patients. The benefit of early risk stratification by the GPS in combination with biomarkers from different pathways should be investigated in further interventional trials.

  7. Procalcitonin (PCT) and C-reactive Protein (CRP) as severe systemic infection markers in febrile neutropenic adults

    Massaro, Karin SR; Costa, Silvia F; Leone, Claudio; Chamone, Dalton AF

    2007-01-01

    Background Procalcitonin (PCT) is an inflammatory marker that has been used as indicator of severe bacterial infection. We evaluated the concentrations of PCT as a marker for systemic infection compared to C-reactive protein (CRP) in patients neutropenic febrile. Methods 52 adult patients were enrolled in the study. Blood sample was collected in order to determine the serum concentrations of PCT, CRP and other hematological parameters at the onset of fever. The patients were divided into 2 groups, one with severe infection (n = 26) and the other in which the patients did not present such an infection (n = 26). Then PCT and CRP concentrations at the fever onset were compared between groups using non parametric statistical tests, ROC curve, sensitivity, specificity, likelihood ratio, and Spearman's correlation coefficient. Results The mean of PCT was significantly higher in the group with severe infection (6.7 ng/mL versus 0.6 ng/mL – p = 0.0075) comparing with CRP. Serum concentrations of 0.245 ng/mL of PCT displayed 100% de sensitivity and 69.2% specificity. PCT concentrations of 2,145 ng/mL presented a likelihood ratio of 13, which was not observed for any concentration of CRP. Conclusion PCT seems to be an useful marker for the diagnosis of systemic infection in febrile neutropenic patients, probably better than CRP. PMID:18034890

  8. Procalcitonin concentrations as a predictor of unexpected readmission and mortality after intensive care unit discharge: A retrospective cohort study.

    Zhou, George; Ho, Kwok M

    2016-06-01

    Procalcitonin (PCT) has been used to guide treatment in critically ill patients with sepsis, but whether PCT at intensive care unit (ICU) discharge can stratify risks of post-ICU readmission or mortality is unknown. This cohort study compared the ability of PCT with C-reactive protein (CRP) in predicting unexpected adverse post-ICU events. Of the 1877 patients admitted to the multidisciplinary ICU between 1 April 2012 and 31 March 2014, 1653 (88.1%) were discharged without treatment limitations. A total of 71 (4.3%) were readmitted and 18 patients (1%) died unexpectedly after ICU discharge during the same hospitalization. Both PCT (0.6 vs 0.4 μg/L, P = .002) and a high CRP concentration >100 mg/L (58% vs 41%, P = .004) at ICU discharge were associated with an increased risk of adverse post-ICU events in the univariate analyses; however, the ability of PCT to discriminate between patients with and without adverse post-ICU outcomes was limited (area under the receiver operating characteristic curve = 0.61; 95% confidence interval, 0.55-0.66). In the multivariable analysis, only a high CRP concentration (odds ratio, 1.92; 95% confidence interval, 1.12-3.11; P = .008) was associated with an increased adverse post-ICU events. Elevated PCT concentration at ICU discharge was inadequate in its predictive ability to guide ICU discharge. PMID:27020769

  9. Procalcitonin neutralizes bacterial LPS and reduces LPS-induced cytokine release in human peripheral blood mononuclear cells

    Matera Giovanni

    2012-05-01

    Full Text Available Abstract Background Procalcitonin (PCT is a polypeptide with several cationic aminoacids in its chemical structure and it is a well known marker of sepsis. It is now emerging that PCT might exhibit some anti-inflammatory effects. The present study, based on the evaluation of the in vitro interaction between PCT and bacterial lipopolisaccharide (LPS, reports new data supporting the interesting and potentially useful anti-inflammatory activity of PCT. Results PCT significantly decreased (p Salmonella typhimurium (rough chemotype and Escherichia coli (smooth chemotype. Subsequently, the in vitro effects of PCT on LPS-induced cytokine release were studied in human peripheral blood mononuclear cells (PBMC. When LPS was pre-incubated for 30 minutes with different concentrations of PCT, the release of interleukin-10 (IL-10 and tumor necrosis factor alpha (TNFα by PBMC decreased in a concentration-dependent manner after 24 hours for IL-10 and 4 hours for TNFα. The release of monocyte chemotactic protein-1 (MCP-1 exhibited a drastic reduction at 4 hours for all the PCT concentrations assessed, whereas such decrease was concentration-dependent after 24 hours. Conclusions This study provides the first evidence of the capability of PCT to directly neutralize bacterial LPS, thus leading to a reduction of its major inflammatory mediators.

  10. Procalcitonin NH2-terminal cleavage peptide has no mitogenic effect on normal human osteoblast-like cells

    The NH2-terminal cleavage peptide of procalcitonin (N-proCT) recently was reported to be a bone cell mitogen. The authors have investigated the effect of N-proCT on the proliferation of normal human cells that have the phenotype of mature osteoblasts (hOB cells). N-proCT treatment for 24, 48, or 96 h in concentrations from 1 nM to 1 microM did not significantly increase [3H]thymidine uptake (means ranged from -19% to 38% of control, no significant differences) in hOB cells (6-10 cell strains per experiment) plated at four different densities. However, the hOB cells responded significantly to treatment with transforming growth factor β (3 ng/ml), bovine insulin (300 micrograms/ml), or 30% fetal calf serum, which were included in all experiments as positive controls. The [3H]thymidine uptake data were confirmed in a direct cell count experiment tested at 96 h. Thus they data do not support the hypothesis that N-proCT is a potent mitogen for normal human osteoblasts

  11. Procalcitonin as a biomarker for severe Plasmodium falciparum disease: a critical appraisal of a semi-quantitative point-of-care test in a cohort of travellers with imported malaria

    Petit Pieter

    2009-09-01

    Full Text Available Abstract Background Imported malaria occurs as a relatively rare event in developed countries. As a consequence, most clinicians have little experience in making clinical assessments of disease severity and decisions regarding the need for parenteral therapy or high-level monitoring. In this study, the diagnostic accuracy of procalcitonin (PCT for severe Plasmodium falciparum disease was assessed in a cohort of 100 consecutive travellers with various species of imported malaria. Methods and results In all patients, PCT was measured on admission with a semi-quantitative 'point-of-care' test. Patients with severe P. falciparum malaria had significantly higher median PCT levels on admission as compared with patients with uncomplicated P. falciparum disease. In addition, PCT levels in patients with non-falciparum malaria were also higher compared with patients with non-severe falciparum malaria but lower compared with severe P. falciparum malaria. At a cut-off point of 10 ng/mL, PCT had a sensitivity of 0,67 and a specificity of 0,94 for severe falciparum disease. However, at lower cut-off points the specificity and positive predictive value were rather poor although the sensitivity and negative predictive value remained high. Discussion Potential drawbacks in the interpretation of elevated PCT levels on admission may be caused by infections with non-falciparum species and by concomitant bacterial infections. Conclusion Semi-quantitative determination of PCT on admission is of limited use in the initial clinical assessment of disease severity in travellers with imported malaria, especially in settings with limited experience with the treatment of malaria.

  12. Comparative Study on Two Methods for the Analysis of Procalcitonin%降钙素原两种检测方法的比较

    曾华; 张智贤; 何秋莹

    2013-01-01

    目的研究降钙素原(procalcitonin,PCT)检测的定量方法和半定量方法检测结果的一致性,为合理选择降钙素原检测方法提供试验依据。方法应用 PCT检测的半定量法(胶体金)和定量法(酶联荧光免疫法)对80例临床标本进行检测,通过直接比较判断检测结果的一致性。结果两种检测方法的结果一致率达到93.75%;当PCT持续高于10ng/ml 时,适合使用定量方法进行监测。结论降钙素原检测的两种方法结果具有一致性,实验室可根据实际情况选择不同的检验方法。%Objective To investigate the comparability of the quantitative and semi-quantitative methods for the analysis of procalcitonin and provide experimental basis for the methods. Methods The 80 clinical samples were analyzed by the quantitative and semi-quantitative methods of procalcitonin respectively. The consistency was decided by the direct comparison. Results The concordance rate of the two methods was 93.75%. It's more necessary using way of quantitative analysis for PCT monitoring While the PCT was higher than 10ng/ml consistently. Conclusion The two methods for the analysis of procalcitonin were comparable and the dif erent method could be selected accordingly.

  13. Sperm abnormalities in exposed humans

    Šrám, Radim; Rubeš, J.

    Cambridge : Issue in Toxicology, Royal Society of Chemistry Publ.,, 2007, s. 247-258. ISBN 978-0-85404-847-2 R&D Projects: GA MŽP SL/740/5/03 Institutional research plan: CEZ:AV0Z50390512 Keywords : air pollution exposure * sperm abnormalities * male reproductive health Subject RIV: DN - Health Impact of the Environment Quality

  14. Pró-calcitonina e proteína C reativa em processos infecciosos graves Procalcitonin and C-reactive protein in septic patients

    Adagmar Andriolo

    2004-06-01

    Full Text Available Marcadores bioquímicos da resposta inflamatória são necessários para a obtenção de evidências objetivas da existência de processos infecciosos. A proteína C reativa (PCR tem sido utilizada para essa finalidade, com baixa especificidade. A pró-calcitonina (PCT foi proposta como marcador mais específico, mas seu valor prognóstico ainda não está bem estabelecido. Avaliamos qual desses marcadores teria maior poder em prever a evolução clínica de pacientes com sepse. Dosamos PCT e PCR no soro de 19 pacientes internados na unidade de tratamento intensivo do Hospital São Paulo, na Escola Paulista de Medicina (EPM, a pró-calcitonina por ensaio imunoluminométrico (LUMItest PCT, Brahms Diagnostica GmbH, Berlin, Germany e a proteína C reativa por imunonefelometria (High Sensitivity CRP, Dade Behring, Marburg, Germany. As concentrações de PCT foram significativamente mais elevadas no grupo de pacientes que faleceram do que no grupo dos que tiveram alta hospitalar (p Biochemical markers for septic processes are necessary in order to obtain objective evidence of sepsis. The C-reactive protein (CRP has been used to that, despite its low specificity. The procalcitonin (PCT was proposed as a more specific marker, but its predictive value is not yet well established. We evaluated which one of that markers could anticipate the clinical output of septic patients. Determination of PCT/CRP was performed in 19 sera from patients from ITU of Hospital São Paulo/EPM. Procalcitonin was measured by immunoluminometric assay (LUMItest PCT, Brahms Diagnostica GmB, Berlin, Germany and C-reactive protein by immunonephelometric assay (N High Sensitivity CRP, Dade Behring, Marburg, Germany. The PCT concentrations are significantly higher in non-survivors than in survivors group (p < 0.002, what did not occur with CRP. We did not observe significant correlation between procalcitonin and C-reactive protein concentrations as in non-survival as survival group

  15. 血清降钙素原检测对评估婴幼儿肺炎预后的价值%Prognostic Values of Serum Procalcitonin Test in Infant Pneumonia

    张勤梅

    2011-01-01

    Objective To investigate the prognostic values of serum procalcitonin ( PCT ) test in infantile pneumonia. Methods A total of 120 infant pneumonia cases were collected between January 2009 and December 2010 in our hospital. Serum PCT were tested in all patients both on admission and 72 h later. Relationship between PCT levels and prognosis was analyzed. Results Serum PCT levels on admission were positively correlated with complication rates ( P 30% ( P < 0. 05 ) .Conclusion PCT levels are positively related to the prognosis of infantile pneumonia and the slower PCT decreases, the more likely for the infant to develop serious complications.%目的 探讨血清降钙素原(PCT)对婴幼儿肺炎预后的评价作用.方法 收集2009-2010年我科住院的120例婴幼儿肺炎患儿,在入院当日及72 h进行血清PCT检查,观察PCT水平与婴幼儿肺炎预后的关系.结果 入院时血清PCT水平与患儿住院并发症发生率呈正相关(P<0.05).入院72 h PCT下降率15%~30%及<15%的患儿并发症发生率明显高于PCT下降率>30%的患儿,差异有统计学意义(P<0.05).结论 PCT越高提示婴幼儿肺炎的预后越差,PCT下降的速率越慢婴幼儿越容易发生严重的并发症.

  16. Use of plasma C-reactive protein, procalcitonin, neutrophils,macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study

    Kofoed, Kristian; Andersen, Ove; Kronborg, Gitte;

    2007-01-01

    parallel with standard measurements of C-reactive protein (CRP), procalcitonin (PCT), and neutrophils. Two composite markers were constructed – one including a linear combination of the three best performing markers and another including all six – and the area under the receiver operating characteristic...

  17. 细菌感染及感染程度与血清降钙素原(Procalcitonin PCT)的相关性分析%Bacterial infections and infection degree and serum Procalcitonin of calcitonin original (PCT) correlation analysis

    陈思宇

    2011-01-01

    目的:探讨血清降钙素原(Procalcitonin PCT)与细菌感染的相关性.方法:采用罗氏Cobas E411电化学发光仪测定患者血清PCT含量,比较在不同致病菌感染中PCT含量的差异,以及脓毒症组与非脓毒症组间的差异.结果:以PCT≥0.5ng/ml为阳性阈值,PCT阳性率为88.24%(15/17);而不同致病菌所致感染组间PCT含量无显著性差异(P>0.05);以PCT≥2.0ng/ml为脓毒症的阳性阈值,脓毒症患者与非脓毒症患者血清PCT含量有显著性差异(P<0.01).PCT对脓毒症的临床诊断灵敏度为81.81%(9/11),特异性为100%(6/6).结论:血清PCT是鉴别细菌性感染引发脓毒血症快捷、敏感、准确的监测手段,优于白细胞计数,但不能够判断为何种细菌感染.

  18. Perceived functional impact of abnormal facial appearance.

    Rankin, Marlene; Borah, Gregory L

    2003-06-01

    Functional facial deformities are usually described as those that impair respiration, eating, hearing, or speech. Yet facial scars and cutaneous deformities have a significant negative effect on social functionality that has been poorly documented in the scientific literature. Insurance companies are declining payments for reconstructive surgical procedures for facial deformities caused by congenital disabilities and after cancer or trauma operations that do not affect mechanical facial activity. The purpose of this study was to establish a large, sample-based evaluation of the perceived social functioning, interpersonal characteristics, and employability indices for a range of facial appearances (normal and abnormal). Adult volunteer evaluators (n = 210) provided their subjective perceptions based on facial physical appearance, and an analysis of the consequences of facial deformity on parameters of preferential treatment was performed. A two-group comparative research design rated the differences among 10 examples of digitally altered facial photographs of actual patients among various age and ethnic groups with "normal" and "abnormal" congenital deformities or posttrauma scars. Photographs of adult patients with observable congenital and posttraumatic deformities (abnormal) were digitally retouched to eliminate the stigmatic defects (normal). The normal and abnormal photographs of identical patients were evaluated by the large sample study group on nine parameters of social functioning, such as honesty, employability, attractiveness, and effectiveness, using a visual analogue rating scale. Patients with abnormal facial characteristics were rated as significantly less honest (p = 0.007), less employable (p = 0.001), less trustworthy (p = 0.01), less optimistic (p = 0.001), less effective (p = 0.02), less capable (p = 0.002), less intelligent (p = 0.03), less popular (p = 0.001), and less attractive (p = 0.001) than were the same patients with normal facial

  19. Echocardiographic abnormalities in hypertensive patients

    A descriptive cross-sectional study was carried out in 120 hypertensive patients with a course of 5 or more years, who went to the emergency room of 'Saturnino Lora' Provincial Teaching Hospital from November 2010 to November 2011 in order to determine the presence or absence of echocardiographic abnormalities typical of hypertension. Of these, 78,3 % was affected, most of whom reported not to continue with regular previous medical treatment, and 21,7 % had not these abnormalities. Age group of 50-60 years, males and blacks prevailed in the case material. The most significant echocardiographic findings were left ventricular hypertrophy and heart failure with ejection fraction of left ventricle preserved

  20. Abnormal sex chromosome constitution and longitudinal growth: serum levels of insulin-like growth factor (IGF)-I, IGF binding protein-3, luteinizing hormone, and testosterone in 109 males with 47,XXY, 47,XYY, or sex-determining region of the Y chromosome (SRY)-positive 46,XX karyotypes

    Aksglaede, L.; Skakkebaek, N.E.; Juul, A.

    2008-01-01

    sitting height, serum levels of reproductive hormones, IGF-I, and IGFBP-3 were measured. RESULTS: In boys with 47,XXY and 47,XYY karyotypes, growth was accelerated already in childhood, compared with healthy boys. 46,XX-males were significantly shorter than healthy boys but matched the stature of healthy...... girls. In 47,XXY sitting height to height ratios were lower than expected, whereas body proportions in 46,XX-males and 47,XYY were normal. In all subjects serum levels of IGF-I and IGFBP-3 were within normal limits. The boys with 46,XX and 47,XXY karyotypes presented with low normal testosterone and...... elevated LH levels after puberty, whereas the sex hormone secretion of the 47,XYY boys remained normal. CONCLUSION: We found accelerated growth in early childhood in boys with 47,XXY and 47,XYY karyotypes, whereas 46,XX-males were shorter than controls. These abnormal growth patterns were not reflected in...

  1. Is Dark Energy Abnormally Weighting?

    Fuzfa, A.; Alimi, J. -M.

    2006-01-01

    We present a new interpretation of dark energy in terms of an \\textit{Abnormally Weighting Energy} (AWE). This means that dark energy does not couple to gravitation in the same way as ordinary matter, yielding a violation of the weak and strong equivalence principles on cosmological scales. The resulting cosmological mechanism accounts for the Hubble diagram of type Ia supernovae in terms of both cosmic acceleration and variation of the gravitational constant while still accounting for the pr...

  2. Computed tomography of thymic abnormalities

    Schnyder, P.; Candardjis, G.

    1987-05-01

    Computed tomographic examinations of 38 patients with surgically and histologically proven diagnosis were reviewed. Twenty subjects (52%) had an invasive thymoma and 16% an hyperplastic thymus. Myasthenia gravis was present in 6 cases (16%) of thymic abnormalities, four (10,5%) with invasive thymoma and two (5%) with thymic hyperplasia. Graves' disease was also present in one case of thymic hyperplasia. We emphasize the contribution of CT to the diagnosis and the prognosis.

  3. Mastoid abnormalities in Down syndrome

    Hearing loss and otitis media are commonly associated with Down syndrome. Hypoplasia of the mastoids is seen in many affected children and sclerosis of mastoid bones is not uncommon in Down syndrome. Awareness and early recognition of mastoid abnormality may lead to appropriate and timely therapy, thereby preserving the child's hearing or compensating for hearing loss; factors which are important for learning and maximum development. (orig.)

  4. Computed tomography abnormalities in hanging

    The CT pattern of bilateral and symmetrical round low density areas in the globi pallidi has been observed in a young man who attempted suicide by hanging. These CT abnormalities are similar to those described in other conditions such as carbon monoxide, hydrogen sulfide, cyanide and methanol poisoning, hypoglycaemia, drowning and acute global central nervous system hypoperfusion.The findings appear to be correlated with acute cerebral hypoxia. (orig.)

  5. Cardiac abnormalities after subarachnoid hemorrhage

    Bilt, I.A.C. van der

    2016-01-01

    Aneurysmal subarachnoid hemorrhage(aSAH) is a devastating neurological disease. During the course of the aSAH several neurological and medical complications may occur. Cardiac abnormalities after aSAH are observed often and resemble stress cardiomyopathy or Tako-tsubo cardiomyopathy(Broken Heart Syndrome) that has been described after acute stress. It is a reversible cardiac dysfunction with distinct imaging features(the echocardiographic or left ventricular angiographic image resembles a Tak...

  6. Procalcitonin guidance on antibiotic therapy in the treatment of AECOPD patients%血清降钙素原对AECOPD抗生素使用的指导价值

    张金龙; 谭亚萍; 敬鸿博; 侯雪飞

    2014-01-01

    Objective To investigate the guidance value of procalcitonin on antibiotic use in the treatment of AECOPD patients. Methods 63 patients with AECOPD were randomly divided into the PCT group (n=32) and the control group (n=31). The serum concentration of procalcitonin (PCT) were measured in all patients. On the base of similar routine treatment, the control group received antibiotics based on the physician 's decision, and the PCT group were treated with antibiotics according to serum PCT levels. The antibiotic treatment was applied when the level of PCT was higher than 0. 25ng/mL and stopped when the level of PCT was lower than 0. 25ng/mL. The duration of antibiotics use and hospital stay was observed. Results The duration of antibiotics use was shorter in the PCT group [7(5~11)d] than in the control group [13(7~16)d] (P=0. 03), and the cost of antibiotics in the PCT group was lower than that in the control group (P=0. 001). There was no significant difference in clinical efficacy and du-ration of hospital stay in the two groups (P>0. 05). Conclusion PCT guidance can reduce antibiotic duration and antibiotic cost in the treatment of AECOPD patients.%目的:研究血清降钙素原( PCT)检测在慢性阻塞性肺疾病急性加重期( AECOPD)对使用抗生素的指导价值。方法选取收治的AECOPD患者63例,随机分配成两组:PCT指导治疗组32例(简称 PCT组)和常规治疗组31例(简称对照组),检测血清PCT水平。在常规治疗的基础上,对照组按照临床抗生素使用指南决定抗生素疗程,PCT组按照血清PCT水平决定抗生素的使用,当血清PCT≥0.25ng/mL时,进行抗生素治疗,当PCT<0.25 ng/mL时,则停止使用抗生素。并观察两组患者抗生素的使用疗程,抗生素所用费用及住院时间。结果 PCT组抗生素疗程[7(5~11)d]短于对照组[13(7~16)d](P=0.03);PCT组抗生素费用低于对照组(P=0.001),两组的住院时间及预后无明显差异。结论 AECOPD患者根据PCT水

  7. 降钙素原在小儿脓毒症中的应用%Application of procalcitonin in children with sepsis

    贺彬

    2013-01-01

    Sepsis is currently a challenge in the pediatric intensive care unit.Especially septic shock and multiple organ dysfunction syndrome have become the main causes of death in patients from pediatric intensive care unit,and the mortality rate is up to 30% ~ 70%.At present,procalcitonin is undoubtedly the best sepsis indicator.This article summarized the application of procalcitonin in children with sepsis.%脓毒症是目前小儿重症监护病房面临的棘手难题,特别是由其诱发的脓毒性休克和多器官功能障碍综合征,已成为危重患儿主要的死亡原因,病死率高达30% ~ 70%.降钙素原无疑是目前最好的脓毒症诊断指标.该文就降钙素原在小儿脓毒症中的应用作一综述.

  8. 降钙素原的临床应用及研究进展%The clinical application and research progress of procalcitonin

    杨扬; 王宋平

    2016-01-01

    降钙素原(procalcitonin,PCT)是一种无激素活性的糖蛋白,作为一种新型的炎症生物学标记物,已广泛用于评判感染的类型及严重程度,指导抗生素的合理应用,以减少抗生素的处方率,避免耐药性的产生。本文着重综述了近年来降钙素原的临床应用及研究进展。%Procalcitonin (PCT) is a glycoprotein without hormone activity.As a novel inflammatory biomarker,PCT has been widely used to identify the type and severity of infection,and to guide the rational use of antibiotics,to reduce the rate of antibiotic prescription and avoid drug resistance to antibiotics.This article reviewed the clinical application and research progress of calcitonin in recent years.

  9. Point-of-care procalcitonin test to reduce antibiotic exposure in patients hospitalized with acute exacerbation of COPD

    Corti, Caspar; Fally, Markus; Fabricius-Bjerre, Andreas; Mortensen, Katrine; Jensen, Birgitte Nybo; Andreassen, Helle F; Porsbjerg, Celeste; Knudsen, Jenny Dahl; Jensen, Jens-Ulrik

    2016-01-01

    Background This study was conducted to investigate whether point-of-care (POC) procalcitonin (PCT) measurement can reduce redundant antibiotic treatment in patients hospitalized with acute exacerbation of COPD (AECOPD). Methods One-hundred and twenty adult patients admitted with AECOPD were enrolled in this open-label randomized trial. Patients were allocated to either the POC PCT-guided intervention arm (n=62) or the control arm, in which antibiotic therapy followed local guidelines (n=58). Results The median duration of antibiotic exposure was 3.5 (interquartile range [IQR] 0–10) days in the PCT-arm vs 8.5 (IQR 1–11) days in the control arm (P=0.0169, Wilcoxon) for the intention-to-treat population. The proportion of patients using antibiotics for ≥5 days within the 28-day follow-up was 41.9% (PCT-arm) vs 67.2% (P=0.006, Fisher’s exact) in the intention-to-treat population. For the per-protocol population, the proportions were 21.1% (PCT-arm) vs 73.9% (P<0.00001, Fisher’s exact). Within 28-day follow-up, one patient died in the PCT-arm and two died in the control arm. A composite harm end point consisting of death, rehospitalization, or intensive care unit admission, all within 28 days, showed no apparent difference. Conclusion Our study shows that the implementation of a POC PCT-guided algorithm can be used to substantially reduce antibiotic exposure in patients hospitalized with AECOPD, with no apparent harm. PMID:27382274

  10. Procalcitonin-guided protocol is not useful to manage antibiotic therapy in febrile neutropenia: a randomized controlled trial.

    Lima, Stella Sala Soares; Nobre, Vandack; de Castro Romanelli, Roberta Maia; Clemente, Wanessa Trindade; da Silva Bittencourt, Henrique Neves; Melo, Ana Catarina Mourão; Salomão, Luciana Caetano Botelho; Serufo, José Carlos

    2016-06-01

    Febrile neutropenia (FN) requires immediate use of antibiotics (ATB), and procalcitonin (PCT) is proven to be useful in guiding antibiotic therapy in different settings. This study investigated the use of PCT as a guide for the duration of ATB in FN. A randomized controlled trial was carried out from January-December 2010. A total of 62 hematological adult patients with FN were randomized, in 1:1 ratio, into two groups: (1) PCT group: length of ATB guided by institutional protocol plus PCT dynamics, and (2) control group: duration of ATB in accordance with institutional protocol. There was no difference between groups regarding the use of ATB for the first episode of fever (HR 1.14, 95 % CI 0.66-1.95, p = 0.641), with equivalent median duration of ATB therapy (PCT group 9.0 days and control group 8.0 days, p = 0.67), and median number of days without ATB (0 days, IQR 0-2 days for both groups, p = 0.96). We observed no difference in clinical cure rate (p = 0.68), infection relapse (p = 1.0), superinfection (p = 0.85), length of hospitalization (p = 0.64), and mortality at 28 days (p = 0.39) and at 90 days (p = 0.72). Considering the cut-off of 0.5 ng/ml, PCT was correlated with bacteremia (sensitivity of 51.9 % and specificity of 76.5 %). In this randomized controlled trial, adding a PCT-guided protocol to the standard recommendations did not reduce the use of antibiotics in febrile neutropenia, although no apparent harm was caused. PCT proved to be a marker of bacteremia in this setting. PMID:27118539

  11. The Abnormal Choroidal Vessels in Aged Patients

    Shizhou Huang; Feng Wen; Dezheng Wu; Guangwei Luo; Caijiao Liu

    2002-01-01

    Background: To show the abnormal choroidal vessels in aged patients with indocyanine-green angiography (ICGA).Methods: ICGA was performed in 350 patients with TOPCON TRC-50IA fundus camera.The images were recorded and retrospectively reviewed.Results: Five aged patients out of 350 cases were found to have abnormal choroidalvessels. The incidence was 1.43%. The abnormal choroidal vessels showed round- shapet,focal enlargement, abnormal shape and entrance, satellite appearance, and vascularloops. These might be due to congenital abnormality of choroid.Conclusion: ICGA could be used to observe the abnormal choroidal vessels.

  12. 血清降钙素原对重症监护病房机械通气的肺炎患者中的评价%Evaluation on the serum procalcitonin in ICU patients with pneumonia requiring mechanical ventilation

    姜琦; 姜利; 朱波; 李春阳

    2012-01-01

    目的 评估血清降钙素原(procalcitonin,PCT)在重症监护病房机械通气的肺炎患者中的价值.方法 采用前瞻性观察研究方法,从2010年1月到2011年9月连续收入首都医科大学附属复兴医院ICU患者中,临床诊断肺炎并进行机械通气的患者,测定入选患者d 1-7的血清PCT水平.结果 共有111名患者入选,其中社区获得性肺炎(CAP)患者35例,医院获得性肺炎(HAP) 37例,呼吸机相关性肺炎(VAP) 39例.CAP组患者的基线PCT水平高于VAP组(P<0.05).入选患者的28 d病死率为27%,平均ICU住院天数为16 d,变化范围(1~135 d).死亡组的PCT水平持续升高,明显高于存活组(P<0.05).基线PCT水平和最高PCT水平与最高SOFA评分具有相关性(r2分别为0.51和0.58).对于基线PCT水平、最高PCT水平和APACHEⅡ评分,利用受试者工作曲线(ROC曲线)预测患者的28 d病死率,曲线下面积分别为0.70、0.74、0.69.基线PCT预测病死率的截断值为1.3 ng/ml,最高PCT预测病死率的截断值为5.1ng/nl.结论 在ICUJ中的因重症肺炎(CAP,HAP,VAP)进行机械通气的患者中,PCT水平与疾病的严重程度密切相关,PCT水平可以预测患者28 d病死率.%OBJECTIVE To evaluate the value of serum procalcitonin (procalcitonin, PCT) in ICU patients with pneumonia requiring mechanical ventilation. METHODS All adult patients who were admitted into the intensive care unit (ICU) of Fuxing Hospital of Capital Medical University were collected from January 2010 to September 2011. All patients were clinical diagnosed with pneumonia requiring mechanical ventilation. The serum PCT level were measured from 1 to 7 days. RESULTS 111 patients were included 35 with ommunity acquired pneumonia (CAP), 37 with hospital acquired pneumonia (HAP), and 39 with ventilator associated pneumonia (VAP). The initial PCT levels were higher in CAP than VAP patients (P < 0.05). The 28-day ICU mortality rate for all patients was 27% with a median ICU length of

  13. Clinical Significance of Procalcitonin (PCT) in Locating the Infection Position in Urinary Tract Infection%降钙素原在尿路感染定位中的临床意义

    王社盈; 罗莉

    2012-01-01

    目的 探讨降钙素原(PCT)在尿路感染定位中的临床意义. 方法 用免疫定量法测定114例尿路感染患者及40例健康者的降钙素原(PCT)、C反应蛋白(CRP). 结果 上尿路感染组患者血清降钙素原(PCT)水平明显高于下尿路感染患者组(P<0.01),PCT对上尿路感染诊断的敏感性为81.1%,特异性为85.5%,阳性预测值为80.3%,阴性预测值为92.5%,均高于CRP. 结论 PCT对尿路感染的定位有临床意义.%Objective To explore the clinical significance of procalcitonin (PCT) in the infection location of urinary tract infection (UTI). Methods The concenstrations of PCT and C- reactive protein (CRP) in serum from 114 patients with UTI were detected by immunolumino- metric assay. Results The serum PCT level in patients with upper urinary tract infection was significantly higher than that in those with lower urinary tract infection (P < 0.01). The sensitivity, specificity, positive predictive value and negative predictive value of PCT for diagnosis of upper urinary tract infection were 81.1%, 85.5 % , 80.3% and 92.5% respectively, which were all higher than thoseof CRP. Conclusions Serum PCT can be used as a marker to differentiate the upper and lower urinary tract infection.

  14. MR imaging of abnormal synovial processes

    MR imaging can directly image abnormal synovium. The authors reviewed over 50 cases with abnormal synovial processes. The abnormalities include Baker cysts, semimembranous bursitis, chronic shoulder bursitis, peroneal tendon ganglion cyst, periarticular abscesses, thickened synovium from rheumatoid and septic arthritis, and synovial hypertrophy secondary to Legg-Calve-Perthes disease. MR imaging has proved invaluable in identifying abnormal synovium, defining the extent and, to a limited degree, characterizing its makeup

  15. CHROMOSOMAL ABNORMALITIES IN PATIENTS WITH SPERM DISORDERS

    L. Y. Pylyp; L. A. Spinenko; V. D. Zukin; N. M. Bilko

    2013-01-01

    Chromosomal abnormalities are among the most common genetic causes of spermatogenic disruptions. Carriers of chromosomal abnormalities are at increased risk of infertility, miscarriage or birth of a child with unbalanced karyotype due to the production of unbalanced gametes. The natural selection against chromosomally abnormal sperm usually prevents fertilization with sperm barring in cases of serious chromosomal abnormalities. However, assisted reproductive technologies in general and intrac...

  16. 糖耐量异常对急性脑梗死患者血浆Hcy和血清hs-CRP水平的影响%The Influence of Abnormal Glucose Tolerance on the Levels of Plasma Homocysteine and Serum High-sensitivity C-reactive Protein in Patients with Acute Cerebral Infarction(ACI)

    赵红东; 陆敏; 唐冰

    2012-01-01

    Objective To observe the influence of abnormal glucose tolerance on the levels of homocysteine and high-sensitivity C-reactive protein in patients with acute cerebral infarction( AGI). Methods 756 patients with AGI were divided into normal glucose tolerance group (NGT, 33 leases) , abnormal glucose tolerance group(IGT,142cases) ,and diabetes mellitus group (DM,283 scase) ac-cording to the result of oral glucose tolerance test( OGTT). The serum levels of Hcy and hs-GRP were measured in 24 hours after ad-mission. Result The both levels of Hey and hs-GRP in IGT group(19.17 9.35juno]/L,20.46 10.56μmol/L) and DM group (8.0 2.9 mg/L,7.7 2.3 mg/L) were higher than the NGT group with no difference between each other. Conclusion The levels of Hey and hs-GRP in patients with AGI and abnormal glucose tolerance rise significantly,which indicate the presence of chronic low-grade inflammation and atherosclerosis in the stage of abnormal glucose tolerance. The results showed abnormal glucose tolerance is the risk factor of atherosclerosis as diabetes mellitus,and the OGTT test is valuable in screening risk factors of AGI and stroke prevention.%目的:观察糖耐量异常对急性脑梗死(acute cerebral infarction,ACI)患者的同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)水平的影响.方法:756例ACI患者按葡萄糖耐量试验(OGTT)结果分为糖耐量正常组(NGT,331例)、单纯性糖耐量异常组(IGT,142例)、2型糖尿病组(DM2,283例).在入院24h之内测定血清Hcy、hs-CRP水平并进行组间比较.结果:IGT组及DM2组的Hcy水平(19.17±9.35)μmol/L、(20.46±10.56)μmol/L以及hs-CRP水平(8.0±2.9)mg/L、(7.7±2.3)mg/L明显高于NGT组(16.17±7.35)μmol/L、(3.5±1.2)mg/L.IGT组及DM2组两组之间的Hcy、hs-CRP水平差异均无统计学意义(P>0.05、P>0.05).结论:单纯性糖耐量异常的ACI患者血清Hcy、hs-CRP水平明显升高,表明在糖耐量异常阶段,已经出现了慢性低水平炎症和动脉粥样硬化的发生.提

  17. Detection of serum procalcitonin in diagnose of pediatric infectious diseases%血清降钙素原检测在儿童感染性疾病中的诊断价值

    林文伟; 郭佳群

    2014-01-01

    目的 探讨血清降钙素原检测在儿童感染性疾病中的诊断价值.方法 将324例患儿根据诊断的疾病分为病毒性感染疾病组(B组)、细菌性感染疾病组(A组)和非感染性疾病组(C组),所有患儿入院后即采集静脉血测全血细胞计数,采用免疫比浊法测定C-反应蛋白浓度,采用免疫色谱法测定PCT浓度.结果 A组PCT、CRP和CBC水平显著高于B组、C组,差异有统计学意义(P<0.05);A组PCT阳性检出率显著高于B组、C组,差异有统计学意义(P<0.05);A组PCT阳性检出率显著高于CRP阳性检出率和CBC阳性检出率,差异有统计学意义(P<0.05).结论 在儿童感染性疾病的诊断中,血清降钙素原是细菌感染性疾病的特异性指标,能够准确鉴别诊断细菌感染性疾病,有助于临床治疗方案的确定,帮助患者尽早康复.%Objective To explore the value of serum procalcitonin in the diagnosis of pediatric infectious diseases.Methods According to the diagnosis of the disease,324 cases were divided into a viral infection group (group B),a bacterial infection group (group A),and a non-infectious diseases group (group C).Complete blood count was carried out,C-reactive protein concentration was determined by immune turbidimetry,and PCT concentrations were measured by immune chromatography in all the children after being admitted into hospital.Result The levels of PCT,CRP,and CBC and the positive rate of PCT were significantly higher in group A than in group B and group C,with statistical differences (P < 0.05).The PCT positive detection rate was significantly higher than the CRP positive detection rate and the CBC positive detection rate in group A,with statistical differences (P < 0.05).Conclusions In the diagnosis of infectious diseases in children,the serum procalcitonin is a specific index of bacterial infections,can accurately diagnose bacterial infection and help pin down the clinical treatment plan,and is helpful for the patients

  18. Abnormal mandibular growth and the condylar cartilage.

    Pirttiniemi, Pertti; Peltomäki, Timo; Müller, Lukas; Luder, Hans U

    2009-02-01

    Deviations in the growth of the mandibular condyle can affect both the functional occlusion and the aesthetic appearance of the face. The reasons for these growth deviations are numerous and often entail complex sequences of malfunction at the cellular level. The aim of this review is to summarize recent progress in the understanding of pathological alterations occurring during childhood and adolescence that affect the temporomandibular joint (TMJ) and, hence, result in disorders of mandibular growth. Pathological conditions taken into account are subdivided into (1) congenital malformations with associated growth disorders, (2) primary growth disorders, and (3) acquired diseases or trauma with associated growth disorders. Among the congenital malformations, hemifacial microsomia (HFM) appears to be the principal syndrome entailing severe growth disturbances, whereas growth abnormalities occurring in conjunction with other craniofacial dysplasias seem far less prominent than could be anticipated based on their often disfiguring nature. Hemimandibular hyperplasia and elongation undoubtedly constitute the most obscure conditions that are associated with prominent, often unilateral, abnormalities of condylar, and mandibular growth. Finally, disturbances of mandibular growth as a result of juvenile idiopathic arthritis (JIA) and condylar fractures seem to be direct consequences of inflammatory and/or mechanical damage to the condylar cartilage. PMID:19164410

  19. Application of procalcitonin in postoperative colorectal cancer patients with dubious bacterial infection%降钙素原在结肠癌术后怀疑细菌感染患者中的应用

    曾水兴

    2014-01-01

    Objective To investigate the application of procalcitonin in postoperative clorectal cancer patients with dubious bacterial in-fection. Method One hundred patients with dubious bacterial infection were randomly divided into two groups,procalcitonin group and con-trol group. In the procalcitonin group,antibiotics were adjusted according to serum procalcitonin concentration. In the control group,antibiot-ics were adjusted according to antibiotic use guide. The antibiotic adjustment rate,wrong diagnostic rate,hospital stays and hospitalization expenses in both groups were recorded. Results In the procalcitonin group,the antibiotic adjustment rate was lower than it in the control group. In the procalcitonin group,the wrong diagnostic rate was lower than it in the control group. In the procalcitonin group,the hospital stays was shorter than it in the control group. In the procalcitonin group,the hospitalization expenses were less than it in the control group. Conclusion Procalcitonin determination can effectively distinguish the patients underwent postoperative infections and is valuable for these patients.%目的:探讨降钙素原在结肠癌术后怀疑细菌感染患者中的应用价值。方法:100例怀疑细菌感染的结肠癌术后患者随机分为两组,即降钙素原组和对照组。降钙素原组患者根据降钙素原血清水平调整抗感染方案,对照组患者则根据《抗菌药物临床应用指导原则》调整抗感染方案。记录两组中需调整抗感染方案的患者数和误诊率,记录两组患者的住院时间和住院费用。结果:降钙素原组需调整抗感染方案的患者明显比对照组的少,降钙素原组的误诊率低于对照组的。降钙素原组患者的住院时间明显比对照组的短,降钙素原组患者的住院费用少于对照组的( P均<0.05)。结论:血清降钙素原检测可有效鉴别结肠癌术后患者是否发生感染,具有一定的应用价值。

  20. Incidental sinus abnormalities in 256 patients referred for brain MRI

    Ghanaati H

    2007-06-01

    Full Text Available Background: Imaging abnormalities in the paranasal sinuses are regularly noted as incidental findings on MRI, however, little is known about their prevalence in the Iranian population. The purpose of this study was to classify these findings in the paranasal sinuses as seen on MRI and to investigate the prevalence, according to site and type of paranasal abnormality. Methods: In this cross-sectional study, the T2-weighted axial MRI of 256 patients with diseases unrelated to their paranasal sinuses were reviewed between May 2002 and June 2003. The findings were categorized according to the anatomic location and the imaging characteristics of the abnormality. The abnormalities recorded included total sinus opacification, mucoperiosteal thickening >5mm, air fluid levels and retention cysts or polyps. Unilateral or bilateral involvement and septal deviation were also noted. A sinus was considered normal if it was fully aerated and no soft-tissue density was apparent within the cavity. Results: Among our cases, 111 (43.5% were male and 145 (56.5% were female. Of these patients, abnormalities in one or more of the sinus groups were found in 110 subjects (42.9%, 55.5% of which were male and 44.5% were female (P=0.001. Maxillary sinus abnormalities were observed in 66.4% of the patients, while ethmoid sinus abnormalities were found in 63.6%. Of the ethmoid abnormalities, 21% were found in the anterior section, 9% in the middle ethmoid, and 8% in the posterior ethmoid. The most common abnormality found was mucosal thickening. Among our cases, 23.4% had septal deviation, which was significantly higher among those with sinusitis (29% versus 19.1%; P<0.01. Of those patients with sinus involvement, 16% were involved in the sphenoid sinus and 5% in the frontal sinus. The results obtained from the patients with sinus abnormality revealed that 85% suffered from cough, nasal obstruction, runny nose, facial pain and post nasal discharge and 24% had been diagnosed

  1. Ventilation abnormalities in pulmonary embolus

    The ventilation scans of 11 patients with angiographically-proven PE were reviewed. All patients had one or more lung perfusion defects. The chest roentgenograph was abnormal in 11 of the patients. The ventilation studies were performed in the posterior positron prior to the perfusion lung scan using Xe-133. The ventilation study consists of washin, equilibrium, and washout images. In four patients with normal washin there was retention of the Xe-133 (delayed washout) at the site of the perfusion defect. All had roentgenographic abnormalities. Another pattern was observed at the sites of some perfusion defects in six patients. In these, there was decreased washin at the perfusion defect location. Two patients had both decreased washin and delayed washout. In only one case was the typical ventilation pattern of normal washin and normal washout. The method of retention is unclear, but may be due to decreased clearance of Xe-133 secondary to decreased blood flow in the area or deposition of some fat soluble component left at the site of embolization. The etiology of the reduced washin is unclear, but may be due to reduced surfactant production. This study suggests that more attention must be paid to the ventilation study, where there may be additional clues to the diagnosis of pulmonary embolus

  2. Abnormal Event Detection Using Local Sparse Representation

    Ren, Huamin; Moeslund, Thomas B.

    2014-01-01

    We propose to detect abnormal events via a sparse subspace clustering algorithm. Unlike most existing approaches, which search for optimized normal bases and detect abnormality based on least square error or reconstruction error from the learned normal patterns, we propose an abnormality...... measurement based on the difference between the normal space and local space. Specifically, we provide a reasonable normal bases through repeated K spectral clustering. Then for each testing feature we first use temporal neighbors to form a local space. An abnormal event is found if any abnormal feature is...

  3. Evaluation of aminotransferase abnormality in dengue patients: A meta analysis.

    Wang, Xiao-Jun; Wei, Hai-Xia; Jiang, Shi-Chen; He, Cheng; Xu, Xiu-Juan; Peng, Hong-Juan

    2016-04-01

    Dengue virus is a type of flavivirus transmitted by Aedes mosquitoes. The symptoms of infection by this virus range from asymptomatic or mild symptomatic dengue fever (DF) to dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). Significant abnormality in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) has been shown in a large number of dengue infection cases and to be indicator for liver injury provided that there are no other combined infections or liver injury. This study aims to assess the abnormal levels of liver aminotransferase in dengue patients. The related literature was searched in multiple databases, including PubMed, Embase, Google Scholar and Cochrane Library. The literature was selected through strict inclusion and exclusion criteria, and the quantitative synthesis of the liver aminotransferase abnormality was performed with R software. The fixed or random effects model was employed based on the results of the statistical test for homogeneity. In total, 15 studies were included. The proportion of AST abnormality with 95% confidence interval (95% CI) was 0.80 (95% CI: 0.56-0.92) in DHF patients and 0.75 (95% CI: 0.63-0.84) in DF patients; the proportion of ALT abnormality was 0.54 (95% CI: 0.34-0.73) in DHF patients and 0.52 (95% CI: 0.41-0.63) in DF patients. Serum ALT and AST levels may be indicators for evaluating liver injury in dengue infection and for diagnosis and treatment effect. PMID:26739659

  4. CHROMOSOMAL ABNORMALITIES IN PATIENTS WITH RECURRENT MISCARRIAGE

    Daniela Mierla

    2012-06-01

    Full Text Available Chromosomal abnormalities are involved in the etiology of recurrent spontaneous pregnancy loss and sub-fertility. The purpose of this study was to determine the frequency and contribution of chromosomal abnormalities in recurrent miscarriages. The results obtained and literature review are helpful in understanding the importance of cytogenetics analysis of female infertility. To investigate the distribution of chromosomal abnormalities in the Romanian population with recurrent miscarriage, karyotype analysis by G-banding was performed from peripheral blood in 967 women infertility. Results: Chromosomal abnormalities were found to 79 women (8,17%. The percentage of chromosomal abnormalities in the studied population correlates with the data in the literature. Chromosomal abnormalities could play the important role in etiology of infertility and are more frequently detected in this group of patients compared to general population. In the infertile couples balanced chromosomal abnormalities are the main cause of spontaneous abortions.

  5. Abnormal Returns and Contrarian Strategies

    Ivana Dall'Agnol

    2003-12-01

    Full Text Available We test the hypothesis that strategies which are long on portfolios of looser stocks and short on portfolios of winner stocks generate abnormal returns in Brazil. This type of evidence for the US stock market was interpreted by The Bondt and Thaler (1985 as reflecting systematic evaluation mistakes caused by investors overreaction to news related to the firm performance. We found evidence of contrarian strategies profitability for horizons from 3 months to 3 years in a sample of stock returns from BOVESPA and SOMA from 1986 to 2000. The strategies are more profitable for shorter horizons. Therefore, there was no trace of the momentum effect found by Jagadeesh and Titman (1993 for the same horizons with US data. There are remaing unexplained positive returns for contrarian strategies after accounting for risk, size, and liquidity. We also found that the strategy profitability is reduced after the Real Plan, which suggests that the Brazilian stock market became more efficient after inflation stabilization.

  6. Coagulation abnormalities in patients with chronic liver disease in Pakistan

    Objective: To determine the coagulation abnormalities and relationship between abnormal clotting tests and the risk of gastrointestinal bleeding (GI) among chronic liver disease (CLD) patients admitted at a tertiary care hospital in Pakistan. Methods: Adult CLD patients admitted at Liaquat University Hospital Jamshoro, during Nov 2004 - Oct 2005, were included in the study. The patients blood were tested for coagulation abnormalities including prothrombin time (PT), activated partial thromboplastin time (aPTT), platelet count and plasma fibrinogen. Association was seen between the abnormal clotting tests and the gastrointestinal bleeding by calculating relative risk (RR) with 95% confidence interval. Results: PT was prolonged in 88% and aPTT was raised in 71% cases of CLD. Both PT and aPTT were prolonged in 67% CLD cases. Approximately 37% CLD cases had decreased platelet count and 15% cases had decreased serum fibrinogen level. Relative risk of GI bleeding with abnormal clotting tests in CLD cases were weakly positive for PT (RR = 1.02; 95% CI, 0.49-2.10), negative for aPTT (RR=0.83; 95% CI, 0.47-1.45), strongly positive for decreased platelet counts (RR = 1.96; 95% CI, 1.08-3.56) and also for decreased fibrinogen level (RR = 1.47; 95% CI, 0.64-3.35). Conclusion: Coagulation abnormalities were profound in CLD. Decrease platelet counts and fibrinogen levels were related with GI bleeding but PT and aPTT were not significantly related with GI bleeding in patients with chronic liver disease. Nevertheless, these parameters (PT and aPTT) were still used as prognostic markers. (author)

  7. Abnormal Nutritional Factors in Patients Evaluated at a Neuropathy Center.

    Latov, Norman; Vo, Mary L; Chin, Russell L; Carey, Bridget T; Langsdorf, Jennifer A; Feuer, Naomi T

    2016-06-01

    Abnormal concentrations of nutritional factors were found in 24.1% of 187 patients with neuropathy who were newly seen at our academic neuropathy referral center over a 1-year period. All patients presented with sensory axonal or small fiber neuropathy. In 7.3%, they were present in association with at least one other identifiable cause for neuropathy. Elevated levels of pyridoxal phosphate or mercury occurred more frequently than deficiencies in vitamins B1, B12, or B6. The nutritional abnormalities are amenable to correction by dietary intervention. PMID:27224436

  8. Procalcitonin as a Marker of Neonatal Sepsis in Intensive Care Units

    Mohammed Ibrahim Aboud

    2010-09-01

    Full Text Available Background: The appropriateness of using serum levels ofprocalcotonin (PCT for early diagnosis of newborn sepsis isstill controversial. Therefore, the objective of the present studywas to compare the usefulness of PCT with those of serumlevels of C-reactive protein (CRP and white blood cell(WBC counts in the diagnosis and response to treatment ofneonatal sepsis.Methods: A total of 47 neonates (1-30 days old were assignedto two control (n=22 and sepsis (n=25 groups. Bloodsamples were obtained at the outset and after 7 days of treatmentfor blood culture, measurement of serum levels of PCTand CRP as well as WBC counts. Data were analyzed usingwithin and between group comparisons.Results: Serum levels of PCT were significantly higher insepsis group (14.1±18.7 ng/ml than that in the control group(0.38±0.43 ng/ml. In addition, after 7 days of treatment neonateswho had achieved clinical recovery had a significantlylower serum PCT levels (0.26±0.37 ng/ml than that of thesame group at the beginning of the study. At a cut-off value of≥ 0.8 ng/ml, the sensitivity, specificity, positive predictivevalue of, and negative predictive value of PCT were 84%,86%, 86% and 84%, respectively.Conclusion: The findings of the present study suggest that serumlevels of PCT might be a more reliable marker of infectionthan serum levels of CRP, or WBC counts in the early diagnosisand responses to antibiotic therapy of neonatal sepsis.

  9. Governança corporativa no Brasil Níveis de governança e rendimentos anormais El gobierno corporativo en Brasil: niveles de la gobernanza empresarial y rendimientos anormales Corporate governance in Brazil: governance levels and abnormal returns

    Jéfferson Augusto Colombo

    2010-10-01

    Full Text Available O objetivo deste paper é identificar eventuais relações significativas no retorno das ações ex ante e ex post de aderência a um dos níveis de Governança Corporativa do mercado de ações brasileiro. Para tanto, o estudo utiliza a técnica de estudo de evento, proposta por Mackinlay (1997, através do uso do teste não paramétrico denominado sign test em diferentes janelas de tempo. Encontraram-se evidências a 5% de que a janela (-5,5 apresenta resultados estatisticamente superiores ao Ibovespa. Porém, quando se utiliza um índice composto pelas cinco ações mais correlacionadas com os ativos como benchmark, denominado ICORREL5, o resultado sugere não haver relação positiva entre as variáveis.El objetivo de este trabajo es identificar potenciales relaciones significativas en el rendimiento de las acciones ex ante y ex post de la adhesión a los niveles de la gobernanza empresarial en el mercado de valores brasileño. Para ello, el estudio utiliza la técnica de estudio del evento, propuesta por Mackinlay (1997, utilizando la prueba no paramétrica denominada sign test en diferentes ventanas de tiempo. Se han encontrado pruebas de un 5% de que la ventana (-5,5 muestra una diferencia estadísticamente superior al Ibovespa. Sin embargo, cuando se utiliza un índice compuesto por las cinco acciones más en correlación con los activos como benchmark, llamado ICORREL5, el resultado sugiere que no hay relación positiva entre las variables.The aim of this paper is to identify any significant relationship in stock returns ex ante and ex post adherence to a levels of Corporate Governance in the Brazilian stock market . To this end, the study uses the event study technique proposed by Mackinlay (1997 , by using the nonparametric test called the sign test in different time windows. We found evidence that the 5 % window ( -5.5 shows a statistically superior to Ibovespa. However, when using an index composed of five actions more closely

  10. Governança corporativa no Brasil: Níveis de governança e rendimentos anormais El gobierno corporativo en Brasil: niveles de la gobernanza empresarial y rendimientos anormales Corporate governance in Brazil: governance levels and abnormal returns

    Jéfferson Augusto Colombo

    2012-01-01

    Full Text Available O objetivo deste paper é identificar eventuais relações significativas no retorno das ações ex ante e ex post de aderência a um dos níveis de Governança Corporativa do mercado de ações brasileiro. Para tanto, o estudo utiliza a técnica de estudo de evento, proposta por Mackinlay (1997, através do uso do teste não paramétrico denominado sign test em diferentes janelas de tempo. Encontraram-se evidências a 5% de que a janela (-5,5 apresenta resultados estatisticamente superiores ao Ibovespa. Porém, quando se utiliza um índice composto pelas cinco ações mais correlacionadas com os ativos como benchmark, denominado ICORREL5, o resultado sugere não haver relação positiva entre as variáveis.El objetivo de este trabajo es identificar potenciales relaciones significativas en el rendimiento de las acciones ex ante y ex post de la adhesión a los niveles de la gobernanza empresarial en el mercado de valores brasileño. Para ello, el estudio utiliza la técnica de estudio del evento, propuesta por Mackinlay (1997, utilizando la prueba no paramétrica denominada sign test en diferentes ventanas de tiempo. Se han encontrado pruebas de un 5% de que la ventana (-5,5 muestra una diferencia estadísticamente superior al Ibovespa. Sin embargo, cuando se utiliza un índice compuesto por las cinco acciones más en correlación con los activos como benchmark, llamado ICORREL5, el resultado sugiere que no hay relación positiva entre las variables.The aim of this paper is to identify any significant relationship in stock returns ex ante and ex post adherence to a levels of Corporate Governance in the Brazilian stock market. To this end, the study uses the event study technique proposed by Mackinlay (1997, by using the nonparametric test called the sign test in different time windows. We found evidence that the 5% window (-5.5 shows a statistically superior to Ibovespa. However, when using an index composed of five actions more closely

  11. Diagnostic Value of Serum Procalcitonin for Mechanically Ventilated Patients with Ventilator-associated Pneumonia%血清降钙素原测定对机械通气患者发生呼吸机相关性肺炎的诊断价值

    郑慧; 刘克喜; 王言理; 陈晓兵; 谢永鹏

    2013-01-01

    Objective :To evaluate the diagnostic value of serum procalcitonin for mechanically ventilated (MV) pa-tients with ventilator-associated pneumonia .Methods :Patients who required more than 48 hours of mechanical ventila-tion from June 1st 2011 to June 1st 2012 at the ICU in the First people’s hospital of Lianyungang were enrolled ,exclu-ding previous or extra-pulmonary organ infection .Patients suspected of VAP were included ,then we measured the ser-um procalcitonin and C-reactive protein levels on the day of admission and recorded maximal body temperature ,white blood cell count ,absolute neutrophil count and prognosis .Results:Among the enrolled patients 23 cases were microbio-logically confirmed ,relatively 27 cases were refuted .Serum procalcitonin [1 .87(0 .91 ,13 .82)ng/ml] and C-reactive protein levels[(16 .54 ± 6 .86)mg/L] ,and maximal body temperature(39 .0 ± 1 .1℃)with VAP were significantly higher than those without VAP[0 .25(0 .10 ,0 .49)ng/ml ,(12 .87 ± 4 .40)mg/L ,(37 .9 ± 1 .4)℃] .The sensitivity (>90% ) , specificity(>70% )and diagnosis rate(>80% )of serum PCT determination for the diagnosis of VAP were supreme . Conclusion:In comparison with the conventional inflammatory makers ,serum PCT is more reliable indicator in early di-agnosis of VAP .%目的:评价血清降钙素原(PCT )测定对机械通气患者发生呼吸机相关性肺炎(VAP)的诊断价值。方法:将2011年6月1日-2012年6月1日连续收住我科机械通气(M V )超过48h的患者作为观察对象,排除存在既往感染或肺外器官感染的患者。当临床怀疑VAP时,患者入选,当日测定血清 PCT 和C反应蛋白(CRP)水平,记录入选24h内最高体温和白细胞计数、中性粒细胞绝对值,以及患者预后。结果:50例入选患者中,依据病原学标本,确诊VAP 23例,未确诊27例。确诊VAP组患者血清PCT[1.87(0.91,13.82)ng/ml]、CRP[(16.54±6.86)mg

  12. Procalcitonine, marqueur de mortalité précoce chez le sujet très âgé

    Gavazzi, Gaetan; Stucker, Fabien; Herrmann, François; Graf, Jean-Daniel; Michel, Jean-Pierre

    2009-01-01

    La procalcitonine est un biomarqueur d'infection mais aussi de sévérité des infections, notamment chez les patients admis en hospitalisation en court séjour. Le pronostic des pathologies aiguës chez le sujet âgé est difficile à évaluer car il est à la fois lié à la pathologie aiguë et à d'autres facteurs tels que le statut fonctionnel ou les pathologies chroniques associées. Peu de biomarqueurs ont été étudiés dans ce cadre. L'objectif de cette étude était d'évaluer l'intérêt de la procalcito...

  13. Risk factors of thyroid abnormalities in bipolar patients receiving lithium: a case control study

    Ahmadi-Abhari, Seyed-Ali; Ghaeli, Padideh; Fahimi, Fanak; Esfahanian, Fatemeh; Farsam, Hasan; Dehpour, Ahmad Reza; Jahanzad, Issa; Hatmi, Zinat-Nadya; Dashti, Simin

    2003-01-01

    Background Lithium-induced thyroid abnormalities have been documented in many studies. They may occur despite normal plasma lithium levels. The objectives of this study were: 1) to determine possible relationship between lithium ratio, defined as erythrocyte lithium concentrations divided by plasma lithium concentrations, and thyroid abnormalities in bipolar patients receiving lithium and 2) to find other possible risk factors for developing thyroid abnormalities in the subjects. Methods Sixt...

  14. 降钙素原在新生儿感染中的应用评价%Application evaluation of procalcitonin in diagnosis of neonatal infection

    吴志新; 花少栋

    2014-01-01

    Procalcitonin (PCT) has been recognized a marker of infectious diseases for the past few years.The value of PCT is specific elevation in infectious diseases or inflammation caused by bacterial and it has an important role in the identification of bloodstream infections,bacterial and non-bacterial,rational usage of antibiotics and prediction disease prognosis.PCT is a high value diagnostic indicators.However,the PCT do not reflect a clear advantage in the diagnosis of neonatal infection.In this paper,the composition of the PCT,the source in the body of PCT,the metabolism of PCT,laboratory testing methods of PCT and its applications in neonatal infection were reviewed in order to gain a deeper understanding of the value of PCT in the neonatal diagnosis of infectious diseases.%降钙素原(procalcitonin,PCT)是近年来发现的感染性疾病的标记物,研究认为在细菌所致炎症或感染性疾病中特异性升高,尤其在血流感染、细菌性与非细菌性的鉴别、抗生素的合理使用及预测疾病预后方面有重要作用,是一种有很高应用价值的诊断指标,而PCT在新生儿感染疾病诊断中并没有体现出明显的优势.本文对PCT的构成、体内来源、代谢、实验室检测方法及在新生儿感染中的应用进行综述,以更深刻了解PCT在新生儿感染性疾病诊断中的价值.

  15. Fibrillin abnormalities and prognosis in Marfan syndrome and related disorders

    Aoyama, T.; Furthmayr, H.; Francke, U.; Gasner, C. [Stanford Univ. Medical Center, CA (United States)

    1995-08-28

    Marfan syndrome (MFS), a multisystem autosomal-dominant disorder, is characterized by mutations of the fibrillin-1 (FBN1) gene and by abnormal patterns of synthesis, secretion, and matrix deposition of the fibrillin protein. To determine the sensitivity and specificity of fibrillin protein abnormalities in the diagnosis of MFS, we studied dermal fibroblasts from 57 patients with classical MFS, 15 with equivocal MFS, 8 with single-organ manifestations, and 16 with other connective tissue disorders including homocystinuria and Ehlers-Danlos syndrome. Abnormal fibrillin metabolism was identified in 70 samples that were classified into four different groups based on quantitation of fibrillin synthesis and matrix deposition. Significant correlations were found for phenotypic features including arachnodactyly, striae distensae, cardiovascular manifestations, and fibrillin groups II and IV, which included 70% of the MFS patients. In addition, these two groups were associated with shortened {open_quotes}event-free{close_quotes} survival and more severe cardiovascular complications than groups I and III. The latter included most of the equivocal MFS/single manifestation patients with fibrillin abnormalities. Our results indicate that fibrillin defects at the protein level per se are not specific for MFS, but that the drastically reduced fibrillin deposition, caused by a dominant-negative effect of abnormal fibrillin molecules in individuals defined as groups II and IV, is of prognostic and possibly diagnostic significance. 25 refs., 3 figs., 6 tabs.

  16. Lithium treatment and thyroid abnormalities

    Bocchetta Alberto

    2006-09-01

    autoimmunity do not much differ from those observed in the general population; h hyperthyroidism and thyroid cancer are observed rarely during lithium treatment. Recommendations Thyroid function tests (TSH, free thyroid hormones, specific antibodies, and ultrasonic scanning should be performed prior to starting lithium prophylaxis. A similar panel should be repeated at one year. Thereafter, annual measurements of TSH may be sufficient to prevent overt hypothyroidism. In the presence of raised TSH or thyroid autoimmunity, shorter intervals between assessments are advisable (4–6 months. Measurement of antibodies and ultrasonic scanning may be repeated at 2-to-3-year intervals. The patient must be referred to the endocrinologist if TSH concentrations are repeatedly abnormal, and/or goitre or nodules are detected. Thyroid function abnormalities should not constitute an outright contraindication to lithium treatment, and lithium should not be stopped if a patient develops thyroid abnormalities. Decisions should be made taking into account the evidence that lithium treatment is perhaps the only efficient means of reducing the excessive mortality which is otherwise associated with affective disorders.

  17. Effects of the Xuebijing injection on procalcitonin in patients with sepsis%血必净注射液对脓毒症患者降钙素原的影响

    张亚静

    2016-01-01

    Effcacy of the Xuebijing injection on procalcitonin in patients with sepsis was investigated. Based on procalcitonin, the treatment group (given the Xuebijing injection plus the conventional treatment) and the control group (treated by the conventional treatment simply) were compared; as the result, the Xuebijing injection on sepsis shows a good effect.%本文旨在探讨血必净注射液对脓毒症患者降钙素原的影响。通过血清降钙素原(PCT)这一指标,对治疗组(血必净注射液加常规治疗)及对照组(常规治疗)进行比较,得知血必净注射液在脓毒症的治疗方面具有较好的疗效。

  18. Screening for fetal chromosome abnormalities during the second trimester

    Objective: To develop a pre -natal screening program for fetal chromosome abnormalities based on risk values calculated from maternal serum markers levels during the second trimester. Methods: Serum levels of AFP, β-HCG, uE3 were determined with CLIA in 1048 pregnant women during 14-21w gestation period and the results were analyzed with a specific software (screening program for Down' s syndrome developed by Beckman) for the risk rate. In those women defined as being of high risk rate, cells from amniotic fluid or umbilical cord blood were studied for karyotype analysis. Results: Of these 1048 women, 77 were designated as being of high risk rate for several chromosome abnormalities i.e. Down's syndrome, open spina bifida and trisomy -18 syndrome (overall positive rate 7.3%). Further fetal chromosome study in 31 of them revealed three proven cases of abnormality. Another cord blood study was performed in a calculated low risk rate case but with abnormal sonographic finding at 31 w gestation and proved to be abnormal (software study false negative). The remaining 46 high risk rate cases either refused future study (n=35) or were lost for follow-up (n=11). Fortunately, all the 35 women refused further study gave birth to normal babies without any chromosome abnormalities discovered on peripheral blood study. Besides, in a trial study, five high risk rate women were again evaluated a few weeks later but with tremendous difference between the results. Conclusion: The present program proves to be clinically useful but needs further study and revision. Many factors may influence the result of the analysis and the duration of gestation period in weeks should be as accurate as possible. At present, in order to avoid getting false negatives, we don't advise a second check in 'high risk' cases. (authors)

  19. CHROMOSOMAL ABNORMALITIES IN PATIENTS WITH RECURRENT MISCARRIAGE

    Daniela Mierla; Viorica Radoi; Veronica Stoian

    2012-01-01

    Chromosomal abnormalities are involved in the etiology of recurrent spontaneous pregnancy loss and sub-fertility. The purpose of this study was to determine the frequency and contribution of chromosomal abnormalities in recurrent miscarriages. The results obtained and literature review are helpful in understanding the importance of cytogenetics analysis of female infertility. To investigate the distribution of chromosomal abnormalities in the Romanian population with recurrent miscarriage, ka...

  20. ABNORMAL CARDIOVASCULAR REFLEXES IN PATIENTS WITH ACHALASIA

    戈峰; 李泽坚; 柯美云

    1994-01-01

    Using 3 non-invasive tests,abnormalities of cardiovascular reflex function were found in 7 of 15 patients with achalasia.Abnormalities of heart rate responses to the Valsalva maneuver,deep breathing ,and standing were moted in patients with autonomic neuropathy defect.The findings are consistent with the hypothesis that an abnormality of vagal function may contribute to the pathogenesis of achalasia.

  1. Do Stock Dividends Generate Abnormal Returns?

    Torgal, Kishan

    2009-01-01

    In this paper I have studied and understood the concepts of stock dividends, stock splits and the announcement effects and the effective day effects by using the standard event studies methodology which measures the significance of the abnormal returns. The previous studies have significant positive abnormal returns. In my results its shown that the as there is some significant abnormal returns which are connected with the announcement and effective day of the stock splits but it changes...

  2. Advances in procalcitonin quantitative detection for the diagnosis and therapy of infectious diseases%定量检测降钙素原在感染性疾病诊疗中的研究进展

    李妍淳; 胡志东

    2010-01-01

    As the mediator of inflammation, procalcitonin is a new marker of high sensitivity and specificity, and also has significant value in the diagnosis, differential diagnosis and therapy of infectious diseases. At present, the detection of procalcitonin is mainly in the method of semi-quantification, and this method has some limitations in the detection range and result interpretation. However, the quantitative detection of procalcitonin is in the modus of enzyme-linked fluorescent assay exactly and promptly, which is especially used for the diagnosis and therapy of infectious diseases. This review is mainly about procalcitonin structure, metabolism, quantitative detection and clinical application in infected diseases.%降钙素原是一项高敏感性和特异性的炎症指标,在感染性疾病的诊断、鉴别诊断和治疗中有着重要价值.目前,临床上应用的多为降钙素原定性检测方法,其在结果判读和检测范围上有一定的限制,而降钙素原定量检测应用酶联荧光分析原理,能及时准确地检测血清降钙素原水平,更加适用于感染性疾病的诊断及治疗效果评估.此文就降钙素原的构成、特性、定量检测方法及其在感染性疾病诊疗中的应用等进行了综述.

  3. 儿童中枢神经系统感染脑脊液降钙素原测定的意义%Significance of cerebrospinal fluid procalcitonin determination of children's central nervous system infection

    薛静; 韩虹; 王文徽

    2015-01-01

    目的:探讨中枢神经系统感染患儿脑脊液降钙素原(PCT)变化的临床意义。方法:采用酶联荧光分析技术检测64例中枢神经系统感染患儿脑脊液降钙素原,25例无神经系统疾病且需腰麻的外科手术患儿作为对照组。结果:化脓性脑膜炎患者脑脊液中的PCT阳性率高于病毒性脑膜炎和对照组(P<0.05)。结论:患儿脑脊液PCT的检测可有助于鉴别中枢神经系统感染性质,对儿童中枢感染性疾病诊治具有重要意义。%Objective:To explore the clinical significance of cerebrospinal fluid procalcitonin change of children with central nervous system infection.Methods:The cerebrospinal fluid procalcitonins of 64 children with central nervous system infection were detected by enzyme-linked fluorescent analysis technology.25 cases of surgical operation children needing lumbar anesthesia and without nervous system diseases were as the control group.Results:The procalcitonin positive rate in cerebrospinal fluid of patients with suppurative meningitis was higher than that of virus meningitis and the control group(P<0.05).Conclusion:The children's cerebrospinal fluid procalcitonin determination can help to identify the central nervous system infection properties.It has important significance on the diagnosis and treatment of children's central nervous system infection.

  4. 降钙素原检测在新生儿高胆红素血症早期鉴别诊断中的价值%Value of procalcitonin detection in the early differential diagnosis of neonatal hyperbilirubinemia

    卓晓峰; 隋华; 杨诗梅

    2015-01-01

    Objective:To explore the application value of procalcitonin detection in the early diagnosis of neonatal hyperbilirubinemia.Methods:142 children with neonatal hyperbilirubinemia were selected.They were divided into the infection group and the non infection group according to the cause.The serum procalcitonin concentration of patients in two groups were detected.Results:The procalcitonin positive rate of the infection group was significantly higher than that of the non infection group(P<0.001).Conclusion:Serum procalcitonin determination has application value in the early identification of infection and non infection factors of neonatal hyperbilirubinemia.It has important guiding significance in antibiotic application.%目的:探讨降钙素原(PCT)在新生儿高胆红素血症早期诊断中的应用价值。方法:收治新生儿高胆红素血症患儿142例,根据病因将其分为感染组和非感染组,对两组患者的血清PCT浓度进行检测。结果:感染组的PCT阳性率明显高于非感染组(P<0.001)。结论:血清降钙素原的测定对早期鉴别新生儿高胆红素血症的感染与非感染因素有应用价值,对抗生素的运用有重要指导意义。

  5. Hemostatic abnormalities in liver cirrhosis

    Kendal YALÇIN

    2009-06-01

    Full Text Available In this study, 44 patients with liver cirrhosis were investigated for hemostatic parameters. Patients with spontaneous bacterial peritonitis, hepatocellular carcinoma, hepatorenal syndrome and cholestatic liver diseases were excluded. Patients were classified by Child-Pugh criterion and according to this 4 patients were in Class A, 20 in Class B and 20 in C. Regarding to these results, it was aimed to investigate the haematological disturbances in liver cirrhotic patients.In the result there was a correlation between activated partial thromboplastin time, serum iron, ferritin, transferrin, haptoglobin and Child-Pugh classification. Besides there was no correlation between prothrombin time, factor 8 and 9, protein C and S, anti-thrombin 3, fibrinogen, fibrin degradation products, serum iron binding capacity, hemoglobin, leukocyte, mean corpuscular volume and Child-Pugh classification.There were significant difference, in terms of AST, ferritin, haptoglobulin, sex and presence of ascites between groups (p0.05. In the summary, we have found correlation between hemostatic abnormalities and disease activity and clinical prognosis in patients with liver cirrhosis which is important in the management of these patients. This is also important for identification of liver transplant candidiates earlier.

  6. Sensorial abnormalities: Smell and taste

    Palheta Neto, Francisco Xavier

    2011-07-01

    Full Text Available Introduction: Taste and smell abnormalities have proven to be an extremely more complex subject than previously regarded. Wide-ranging nosologic entities arise along with smell and taste alterations, and they can be congenital or acquired. Objective: Analyze the main features of smell and taste dysfunctions. Method: Automated databases were used to collect data, by searching keywords like 'alteration', 'smell', and 'taste'. A non-systematic search was also made in scientific printings and medical books. Literature Review: Smell and taste dysfunctions have a vast etiology, the most significant of which are obstructive nasal and sinusal disease, infections of the upper respiratory tract, cranioencephalic trauma, aging, exposure to toxics and some drugs, nasal or intracranial neoplasias, psychiatric and neurological pathologies, iatrogenic disease, idiopathic and congenital causes. A detailed anamnesis, a careful physical examination and supplementary evaluations are important for the diagnosis of these alterations. Conclusion: As a rule, smell and taste dysfunctions occur in a combined way. The early discovery of such dysfunctions can lead to a more efficient treatment, making the progress of diseases causing them retard and the symptoms less severe. In many cases, treating these alterations is not easy and there needs to be a multidisciplinary cooperation among the otorhinolaryngologist, endocrinologist, neurologist, psychiatrist, among others.

  7. Holoprosencephaly due to numeric chromosome abnormalities.

    Solomon, Benjamin D; Rosenbaum, Kenneth N; Meck, Jeanne M; Muenke, Maximilian

    2010-02-15

    Holoprosencephaly (HPE) is the most common malformation of the human forebrain. When a clinician identifies a patient with HPE, a routine chromosome analysis is often the first genetic test sent for laboratory analysis in order to assess for a structural or numerical chromosome anomaly. An abnormality of chromosome number is overall the most frequently identified etiology in a patient with HPE. These abnormalities include trisomy 13, trisomy 18, and triploidy, though several others have been reported. Such chromosome number abnormalities are almost universally fatal early in gestation or in infancy. Clinical features of specific chromosome number abnormalities may be recognized by phenotypic manifestations in addition to the HPE. PMID:20104610

  8. Radiologic atlas of pulmonary abnormalities in children

    This book is an atlas about thoracic abnormalities in infants and children. The authors include computed tomographic, digital subtraction angiographic, ultrasonographic, and a few magnetic resonance (MR) images. They recognize and discuss how changes in the medical treatment of premature infants and the management of infection and pediatric tumors have altered some of the appearances and considerations in these diseases. Oriented toward all aspects of pulmonary abnormalities, the book starts with radiographic techniques and then discusses the normal chest, the newborn, infections, tumors, and pulmonary vascular diseases. There is comprehensive treatment of mediastinal abnormalities and a discussion of airway abnormalities

  9. The effect of food shape abnormality on purchase intentions in China

    Loebnitz, Natascha; Grunert, Klaus G

    2015-01-01

    The assumption that consumers prefer cosmetically perfect fruits and vegetables contributes to global food waste, because food retailers refuse to offer abnormally shaped food. This study empirically examines how food shape abnormality affects purchase intentions and how two individual difference...... variables, environmental concern and social trust, might moderate the food shape abnormality–purchase intention relationship for consumers in China. A representative sample of 212 Chinese consumers indicated their purchase intentions for two fruits and two vegetables with varying levels of food shape...... abnormality (normal, moderately abnormal, and extremely abnormal). The results demonstrate that food shape influences purchase intentions; consumers are more likely to purchase normally shaped fruits and vegetables than moderately or extremely abnormally shaped food. However, environmental concern and social...

  10. Abnormalities in central and peripheral nerve conduction in patients with anorectal incontinence.

    Snooks, S J; Swash, M; Henry, M M

    1985-01-01

    Thirty women with idiopathic anorectal incontinence were investigated by nerve conduction studies. Twenty-two (73%) patients had abnormal nerve conduction studies. In 7 (23%) of these patients there was conduction delay in the cauda equina between L1 and L4 vertebral levels but in the remainder the distal innervation of the pelvic sphincters was abnormal.

  11. Complex radiation diagnosis of associated intracardiac abnormality

    It is shown that patients with congenital heart diseases having signs of cardiodismorphic complex in form of associated intercardiac abnormalities require special attention after surgical correction of the principal defect. It is connected with the fact that the associated abnormalities may become with time the basic factors influencing the progress and forecast of the disease

  12. An Abnormal Psychology Community Based Interview Assignment

    White, Geoffry D.

    1977-01-01

    A course option in abnormal psychology involves students in interviewing and observing the activities of individuals in the off-campus community who are concerned with some aspect of abnormal psychology. The technique generates student interest in the field when they interview people about topics such as drug abuse, transsexualism, and abuse of…

  13. An Abnormal Vibrational Mode of Torsion Pendulum

    赵亮; 涂英; 顾邦明; 胡忠坤; 罗俊

    2003-01-01

    In the experiment for the determination of the gravitational constant G, we found an abnormal vibrational mode of the torsion pendulum. The abnormal mode disappeared as a magnetic damper was introduced to the torsion pendulum system. Our experimental results also show that the magnetic damper can be used to suppress the high frequency vibrational noises to torsion pendulums effectively.

  14. EVALUATING MORTALITY RATE CAUSED BY ELECTROLYTE ABNORMALITIES IN PATIENTS HOSPITALIZED

    B. Khorasani

    2008-05-01

    Full Text Available Adjustment of composition of body fluids and electrolytes is one of the most important aspects of patients care. Sodium and Potassium are the most important body cations, the improper adjustment of them will cause sever disorders in neuromuscular, gastrointestinal, respiratory and cardiovascular systems. Acute renal failure indicated by increase in creatinine and nitrogen urea, brings an accumulation of fluids, salts and metabolites of nitrogen in body. This study intends to assess the status of electrolyte abnormalities and mortality rates of the patients hospitalized in ICU wards in our country. This is a descriptive and retrospective study on the records of 378 patients hospitalized in ICU. A questionnaire was prepared and the data were entered in SPSS system. They were statistically analyzed by using chi-square and fisher's Exact test methods. Out of 378 patients hospitalized in ICU, over 2/3 of them were male and over half of them were>45 years old. Frequency distribution of electrolyte abnormalities was as follows: Hyponatremia 59% hypernatremia 23% hypokalemia 37% hyperkalemia 28%, 35% and 21% of patients had respectively BUN and creatinine more than the normal range. 26% of patients hospitalized in ICU had nonsurgical problems and 74% of the patients had surgical problems. Average time of hospitalization in ICU was 85 days and mortality rate was 35%. The most common electrolyte abnormality was related to variation in serum sodium levels in the form of hyponatremia. And the highest prevalence electrolyte abnormality in dead patients was hyponatremia. This study proves that the prevalence of electrolyte abnormalities is directly related to mortality and increase in hospitalization period and those having undergone surgical operations during hospitalization in ICU, manifested more abnormalities.

  15. [Abnormality in bone metabolism after burn].

    Gong, X; Xie, W G

    2016-08-20

    Burn causes bone metabolic abnormality in most cases, including the changes in osteoblasts and osteoclasts, bone mass loss, and bone absorption, which results in decreased bone mineral density. These changes are sustainable for many years after burn and even cause growth retardation in burned children. The mechanisms of bone metabolic abnormality after burn include the increasing glucocorticoids due to stress response, a variety of cytokines and inflammatory medium due to inflammatory response, vitamin D deficiency, hypoparathyroidism, and bone loss due to long-term lying in bed. This article reviews the pathogenesis and regularity of bone metabolic abnormality after burn, the relationship between bone metabolic abnormality and burn area/depth, and the treatment of bone metabolic abnormality, etc. and discusses the research directions in the future. PMID:27562160

  16. Chromosomal abnormalities in patients with sperm disorders

    L. Y. Pylyp

    2013-02-01

    Full Text Available Chromosomal abnormalities are among the most common genetic causes of spermatogenic disruptions. Carriers of chromosomal abnormalities are at increased risk of infertility, miscarriage or birth of a child with unbalanced karyotype due to the production of unbalanced gametes. The natural selection against chromosomally abnormal sperm usually prevents fertilization with sperm barring in cases of serious chromosomal abnormalities. However, assisted reproductive technologies in general and intracytoplasmic sperm injection in particular, enable the transmission of chromosomal abnormalities to the progeny. Therefore, cytogenetic studies are important in patients with male factor infertility before assisted reproduction treatment. The purpose of the current study was to investigate the types and frequencies of chromosomal abnormalities in 724 patients with infertility and to estimate the risk of chromosomal abnormalities detection in subgroups of patients depending on the severity of spermatogenic disruption, aiming at identifying groups of patients in need of cytogenetic studies. Karyotype analysis was performed in 724 blood samples of men attending infertility clinic. Chromosomal preparation was performed by standard techniques. At least 20 GTG-banded metaphase plates with the resolution from 450 to 750 bands per haploid set were analysed in each case. When chromosomal mosaicism was suspected, this number was increased to 50. Abnormal karyotypes were observed in 48 (6.6% patients, including 67% of autosomal abnormalities and 33% of gonosomal abnormalities. Autosomal abnormalities were represented by structural rearrangements. Reciprocal translocations were the most common type of structural chromosomal abnormalities in the studied group, detected with the frequency of 2.6% (n = 19, followed by Robertsonian translocation, observed with the frequency of 1.2% (n = 9. The frequency of inversions was 0.6% (n = 4. Gonosomal abnormalities included 14 cases

  17. Who Buys Oddly Shaped Food and Why? Impacts of Food Shape Abnormality and Organic Labeling on Purchase Intentions

    Loebnitz, Natascha; Schuitema, Geertje; Grunert, Klaus G

    2015-01-01

    experimentally. A representative sample of 964 Danish consumers indicated their purchase intentions for two fruits and two vegetables with varying levels of food shape abnormality (normal, moderately abnormal, and extremely abnormal) and organic labels (organic label, no label). Food shape abnormalities...... influence consumers’ purchase intentions, but only if the food deviates extremely from the norm; no differences in purchase intentions emerge for moderately abnormal food. Awareness of food waste issues and proenvironmental self-identities also drive purchase intentions, such that participants with high...... levels of these traits express significantly higher purchase intentions for abnormally shaped food. Thus, increasing awareness of food waste issues, particularly among those with strong proenvironmental self-identities, might encourage more consumers to purchase abnormally shaped fruits and vegetables....

  18. Cortical thickness abnormalities associated with dyslexia, independent of remediation status

    Ma, Yizhou; Koyama, Maki S.; Milham, Michael P.; Castellanos, F. Xavier; Quinn, Brian T.; Pardoe, Heath; Wang, Xiuyuan; Kuzniecky, Ruben; Devinsky, Orrin; Thesen, Thomas; Blackmon, Karen

    2014-01-01

    Abnormalities in cortical structure are commonly observed in children with dyslexia in key regions of the “reading network.” Whether alteration in cortical features reflects pathology inherent to dyslexia or environmental influence (e.g., impoverished reading experience) remains unclear. To address this question, we compared MRI-derived metrics of cortical thickness (CT), surface area (SA), gray matter volume (GMV), and their lateralization across three different groups of children with a historical diagnosis of dyslexia, who varied in current reading level. We compared three dyslexia subgroups with: (1) persistent reading and spelling impairment; (2) remediated reading impairment (normal reading scores), and (3) remediated reading and spelling impairments (normal reading and spelling scores); and a control group of (4) typically developing children. All groups were matched for age, gender, handedness, and IQ. We hypothesized that the dyslexia group would show cortical abnormalities in regions of the reading network relative to controls, irrespective of remediation status. Such a finding would support that cortical abnormalities are inherent to dyslexia and are not a consequence of abnormal reading experience. Results revealed increased CT of the left fusiform gyrus in the dyslexia group relative to controls. Similarly, the dyslexia group showed CT increase of the right superior temporal gyrus, extending into the planum temporale, which resulted in a rightward CT asymmetry on lateralization indices. There were no group differences in SA, GMV, or their lateralization. These findings held true regardless of remediation status. Each reading level group showed the same “double hit” of atypically increased left fusiform CT and rightward superior temporal CT asymmetry. Thus, findings provide evidence that a developmental history of dyslexia is associated with CT abnormalities, independent of remediation status. PMID:25610779

  19. Cortical thickness abnormalities associated with dyslexia, independent of remediation status

    Yizhou Ma

    2015-01-01

    Full Text Available Abnormalities in cortical structure are commonly observed in children with dyslexia in key regions of the “reading network.” Whether alteration in cortical features reflects pathology inherent to dyslexia or environmental influence (e.g., impoverished reading experience remains unclear. To address this question, we compared MRI-derived metrics of cortical thickness (CT, surface area (SA, gray matter volume (GMV, and their lateralization across three different groups of children with a historical diagnosis of dyslexia, who varied in current reading level. We compared three dyslexia subgroups with: (1 persistent reading and spelling impairment; (2 remediated reading impairment (normal reading scores, and (3 remediated reading and spelling impairments (normal reading and spelling scores; and a control group of (4 typically developing children. All groups were matched for age, gender, handedness, and IQ. We hypothesized that the dyslexia group would show cortical abnormalities in regions of the reading network relative to controls, irrespective of remediation status. Such a finding would support that cortical abnormalities are inherent to dyslexia and are not a consequence of abnormal reading experience. Results revealed increased CT of the left fusiform gyrus in the dyslexia group relative to controls. Similarly, the dyslexia group showed CT increase of the right superior temporal gyrus, extending into the planum temporale, which resulted in a rightward CT asymmetry on lateralization indices. There were no group differences in SA, GMV, or their lateralization. These findings held true regardless of remediation status. Each reading level group showed the same “double hit” of atypically increased left fusiform CT and rightward superior temporal CT asymmetry. Thus, findings provide evidence that a developmental history of dyslexia is associated with CT abnormalities, independent of remediation status.

  20. Application Value of Serum Procalcitonin Detection in the Pediatric Infec-tious Disease%血清降钙素原检测在儿科感染性疾病中的应用价值

    毛莲

    2016-01-01

    目的:探讨PCT检测在儿科感染性疾病中的应用价值方法整群选择该院2012年12月—2014年2月份收治的348例儿科感染性疾病患者,将患儿分为3组,所有患儿入院后检测WBC、CRP、PCT 。结果 A组PCT、CRP和WBC水平显著高于B组、C组,差异有统计学意义(P<0.05);A组PCT阳性占86.40%, B组中PCT阳性占18.26%,C组PCT阳性占3.98%,A组PCT阳性检出率显著高于B组、C组,差异有统计学意义(P<0.05);A组PCT阳性检出率显著高于CRP阳性检出率和WBC阳性检出率,差异有统计学意义(P<0.05)。结论在儿科感染性疾病的诊断中,血清降钙素原能够准确鉴别诊断细菌感染性疾病,适用于基层医院的广泛推广。%Objective To study the application value of PCT detection in the pediatric infectious disease. Methods 348 cases of children with infections disease admitted in our hospital from December 2012 to February 2014 were selected and divided into three groups, and the WBC, CRP and PCT of all children were detected after admission. Results The PCT, CRP and WBC levels in the group A were obviously higher than those in the group B and those in the group C, and the dif-ferences had statistical significance(P<0.05), the positive PCT accounted for 86.40% in the group A, 18.26%in the group B and 3.98% in the group C, and the positive detection rate of PCT in the group A was obviously higher than that in the group B and that in the group C, and the differences had statistical significance (P<0.05). Conclusion Serum procalcitonin can accurately and differentially diagnose bacterial infectious diseases in diagnosis of the pediatric infectious disease, which is suitable for wide promotion in the primary hospital.

  1. Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory tract infections in primary care: study protocol for a randomised controlled trial and baseline characteristics of participating general practitioners [ISRCTN73182671

    Bucher Heiner C

    2005-08-01

    Full Text Available Abstract Background Acute respiratory tract infections (ARTI are among the most frequent reasons for consultations in primary care. Although predominantly viral in origin, ARTI often lead to the prescription of antibiotics for ambulatory patients, mainly because it is difficult to distinguish between viral and bacterial infections. Unnecessary antibiotic use, however, is associated with increased drug expenditure, side effects and antibiotic resistance. A novel approach is to guide antibiotic therapy by procalcitonin (ProCT, since serum levels of ProCT are elevated in bacterial infections but remain lower in viral infections and inflammatory diseases. The aim of this trial is to compare a ProCT-guided antibiotic therapy with a standard approach based on evidence-based guidelines for patients with ARTI in primary care. Methods/Design This is a randomised controlled trial in primary care with an open intervention. Adult patients judged by their general practitioner (GP to need antibiotics for ARTI are randomised in equal numbers either to standard antibiotic therapy or to ProCT-guided antibiotic therapy. Patients are followed-up after 1 week by their GP and after 2 and 4 weeks by phone interviews carried out by medical students blinded to the goal of the trial. Exclusion criteria for patients are antibiotic use in the previous 28 days, psychiatric disorders or inability to give written informed consent, not being fluent in German, severe immunosuppression, intravenous drug use, cystic fibrosis, active tuberculosis, or need for immediate hospitalisation. The primary endpoint is days with restrictions from ARTI within 14 days after randomisation. Secondary outcomes are antibiotic use in terms of antibiotic prescription rate and duration of antibiotic treatment in days, days off work and days with side-effects from medication within 14 days, and relapse rate from the infection within 28 days after randomisation. Discussion We aim to include 600

  2. Chromagen lenses and abnormal colour perception

    O. Matthew Oriowo

    2011-12-01

    Full Text Available Background: The Chromagen lens system comprises of tinted spectacle or contact lenses, each with a specific colour wavelength filter which controls the spectra of the light entering the eye. This study investigated whether spectacle-mounted Chromagen lenses would enhance colour perception in individuals with abnormal colour vision.Methods: The Ishihara colour test was used to test for colour vision deficiency (CVD and also to evaluate the effect of the Chromagen spectacle lens on colour perception in 13 subjects. An Oculus Anomaloscope was used to confirm and sub-classify the types of CVD. Subjects comprised of school age children from the Riyadh area in Saudi Arabia.Results: The distribution amongst the male participants comprised two subjects with protanomaly, two with protanopia, five with deuteranomaly, and two with deuteranopia. Amongst the two female participants, one subject showed deuteranomaly, and one showed protanomaly. Different types of Chromagen spectacle lenses displayed some levels of colour vision enhancement depending on type of CVD.Conclusion: The findings support the notion that chromagen lenses could enhance colour vision perception in some cases of red-green colour vision defects. Clients with CVD should be managed on an individual case basis. (S Afr Optom 2011 70(2 69-74 

  3. Abnormal sterol metabolism in holoprosencephaly: studies in cultured lymphoblasts

    Haas, D; Morgenthaler, J; Lacbawan, F; Long, B; Runz, H; Garbade, S F; Zschocke, J; Kelley, R I; Okun, J G; Hoffmann, G F; Muenke, M

    2007-01-01

    Background Holoprosencephaly (HPE) is the most common structural malformation of the developing forebrain in humans. The aetiology is heterogeneous and remains unexplained in approximately 75% of patients. Objective To examine cholesterol biosynthesis in lymphoblastoid cell lines of 228 patients with HPE, since perturbations of cholesterol homeostasis are an important model system to study HPE pathogenesis in animals. Methods An in vitro loading test that clearly identifies abnormal increase of C27 sterols in lymphoblast‐derived cells was developed using [2‐14C] acetate as substrate. Results 22 (9.6%) HPE cell lines had abnormal sterol pattern in the in vitro loading test. In one previously reported patient, Smith–Lemli–Opitz syndrome was diagnosed, whereas others also had clearly reduced cholesterol biosynthesis of uncertain cause. The mean (SD) cholesterol levels were 57% (15.3%) and 82% (4.7%) of total sterols in these cell lines and controls, respectively. The pattern of accumulating sterols was different from known defects of cholesterol biosynthesis. In six patients with abnormal lymphoblast cholesterol metabolism, additional mutations in genes known to be associated with HPE or chromosomal abnormalities were observed. Conclusions Impaired cholesterol biosynthesis may be a contributing factor in the cause of HPE and should be considered in the evaluation of causes of HPE, even if mutations in HPE‐associated genes have already been found. PMID:17237122

  4. Early detection of abnormal patient arrivals at hospital emergency department

    Harrou, Fouzi

    2015-10-21

    Overcrowding is one of the most crucial issues confronting emergency departments (EDs) throughout the world. Efficient management of patient flows for ED services has become an urgent issue for most hospital administrations. Handling and detection of abnormal situations is a key challenge in EDs. Thus, the early detection of abnormal patient arrivals at EDs plays an important role from the point of view of improving management of the inspected EDs. It allows the EDs mangers to prepare for high levels of care activities, to optimize the internal resources and to predict enough hospitalization capacity in downstream care services. This study reports the development of statistical method for enhancing detection of abnormal daily patient arrivals at the ED, which able to provide early alert mechanisms in the event of abnormal situations. The autoregressive moving average (ARMA)-based exponentially weighted moving average (EWMA) anomaly detection scheme proposed was successfully applied to the practical data collected from the database of the pediatric emergency department (PED) at Lille regional hospital center, France.

  5. Numerically abnormal chromosome constitutions in humans

    NONE

    1993-12-31

    Chapter 24, discusses numerically abnormal chromosome constitutions in humans. This involves abnormalities of human chromosome number, including polyploidy (when the number of sets of chromosomes increases) and aneuploidy (when the number of individual normal chromosomes changes). Chapter sections discuss the following chromosomal abnormalities: human triploids, imprinting and uniparental disomy, human tetraploids, hydatidiform moles, anomalies caused by chromosomal imbalance, 13 trisomy (D{sub 1} trisomy, Patau syndrome), 21 trisomy (Down syndrome), 18 trisomy syndrome (Edwards syndrome), other autosomal aneuploidy syndromes, and spontaneous abortions. The chapter concludes with remarks on the nonrandom participation of chromosomes in trisomy. 69 refs., 3 figs., 4 tabs.

  6. Sleep physiology, abnormal States, and therapeutic interventions.

    Wickboldt, Alvah T; Bowen, Alex F; Kaye, Aaron J; Kaye, Adam M; Rivera Bueno, Franklin; Kaye, Alan D

    2012-01-01

    Sleep is essential. Unfortunately, a significant portion of the population experiences altered sleep states that often result in a multitude of health-related issues. The regulation of sleep and sleep-wake cycles is an area of intense research, and many options for treatment are available. The following review summarizes the current understanding of normal and abnormal sleep-related conditions and the available treatment options. All clinicians managing patients must recommend appropriate therapeutic interventions for abnormal sleep states. Clinicians' solid understanding of sleep physiology, abnormal sleep states, and treatments will greatly benefit patients regardless of their disease process. PMID:22778676

  7. Sleep deprivation induces abnormal bone metabolism in temporomandibular joint

    Geng, Wei; Wu, Gaoyi; Huang, Fei; Zhu, Yong; Nie, Jia; He, Yuhong; Chen, Lei

    2015-01-01

    Background: The purpose of this study was to explore the effect of experimental sleep deprivation (SD) on the temporomandibular joint (TMJ) of rats and the possible mechanism related to abnormal bone metabolism. Material and methods: SD was induced by a modified multiple platform method and assessed by serum adrenocorticotropic hormone (ACTH) level. TMJs were detached and stained with hematoxylin and eosin (H&E). Expression of interleukin-1β (IL-1β), tumor necrosis factor alpha (TNF-α), osteo...

  8. 降钙素原的克隆表达及多克隆抗体制备%Cloning,expression and the polyclonal antibody preparation of procalcitonin

    王春芳; 周新; 谢焱; 郑璇

    2011-01-01

    目的 克隆表达与纯化降钙素原(PCT),制备多克隆抗体,为其单抗制备及在临床上的应用研究提供有用的实验基础.方法 培养人甲状腺髓伴癌细胞株(TT细胞)提取总RNA进行RT-PCR获取PCT的全长基因,构建pET-PCT重组质粒,转化至DE3经IPTG诱导表达出融合蛋白,纯化并进行10%聚丙烯酰胺凝胶电泳(SDS-PAGE)、质谱测序,融合蛋白免疫兔制备多抗,采用ELISA和Western-blot进行鉴定.结果 成功获得PCT全长基因,10%SDS-PAGE电泳和质谱测序证明表达的融合蛋白为PCT,成功制备了PCT多抗.结论 成功获得PCT的全长基因,表达出融合蛋白并制备多抗,为研究PCT的病理、生理作用及功能奠定基础,为PCT的单抗制备及在临床应用研究提供了有用的实验材料.%Objective To construct Pet-PCT recombinant plasmid which contained the full length sequence of human PCT gene, express fusion protein,and produce polyclonal antibody production of PCT to serve as a useful experimental basis for preparing the procalcitonin monoclonal antibody and clinical application. Methods Full length Mrna of PCT was obtained from TT cells through RT-PCR,and inserted into Pet-32a( + ) expression vector,which was used to transfect E. Coli DE3 cells. Transfected DE3 cells were induced by IPTG to produce fusion PCT protein. The fusion protein with His tag was purified by Ni-NTA affinity chro-matography column, and verified by multiple techniques such as 10% sodium dodecy sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) ,and MALDI-TOF mass spectrometry. The purified protein was used to immunize New Zealand rabbit to produce polyclonal antibody, which was verified by ELISA and Western blot. Results Recombinant vectors containing full length PCT Mrna insert were constructed,and were used to transfect the E. Coli DE3 cells for producing recombinant PCT protein. SDS-PAGE and MALDI-TOF mass spectrometry results showed the characteristics of the recombinant protein

  9. 产后抑郁症患者正性和负性音乐刺激下情绪反应及脑激活特征%Abnormal pleasure levels and neural processing in response to positive and negative music in postpartum depression: a preliminary functional magnetic resonance imaging study

    王晓娟; 王健; 刘志宏

    2014-01-01

    目的 探讨产后抑郁症患者正、负性音乐刺激下的情绪反应及脑激活特征.方法 选取符合DSM-Ⅳ产褥期抑郁症诊断标准且爱丁堡产后抑郁量表评分≥9分的11例产后抑郁症患者(抑郁症组)和11名产后对照者(对照组),在正、负性音乐刺激下进行脑功能磁共振扫描,比较两组被试者的主观愉悦度评价(人像自评系统量表评分)和脑功能磁共振扫描激活脑区的差异.结果 抑郁症组对正、负性音乐的主观愉悦度评价[分别为:(6.23±1.01)、(3.08±0.64)分]均低于对照组[分别为:(7.00±0.63)、3.72 ±0.47)分],差异有统计学意义(t=-2.27,P=0.03;t=-2.79,P=0.01).在负性刺激下,与对照组相比,抑郁症组患者表现为海马的激活增强,并且右侧海马的激活与主观愉悦度评价水平呈负相关.结论 产后抑郁症患者对负性音乐的愉悦度评价更低,其可能与右侧海马的异常激活有关.%Objective To explore the neural activity of females with post-partum depression in response to negative and positive emotional music and further to examine the relationship between the psychological pleasure levels and the abnormal neural activity in post-partum depression.Methods Eleven postpartum healthy females and 11 unmediated depressed females underwent functional magnetic resonance imaging blood-oxygen-level-dependent acquisition during a block-designed emotional music.Results The depressed females showed lower pleasure levels both to the positive and negative music(6.23 ± 1.01,3.08 ± 0.64,respectively) than healthy ones (7.00 ± 0.63,3.72 ± 0.47,respectively),the difference was statistically significant(t =-2.27,P =0.03 ; t =-2.79,P =0.01).Postpartum depression patients exhibited significantly stronger hippocampus activation than the healthy subjects and there was a significant negative correlation between right hippocampus activity and psychological pleasure levels to negative music.Conclusion Postpartum depressied

  10. Abnormal Sterol Metabolism in Holoprosencephaly

    Haas, Dorothea; Muenke, Maximilian

    2010-01-01

    Holoprosencephaly (HPE) is the most common structural malformation of the developing forebrain in humans. The HPE phenotype is extremely variable and the etiology is heterogeneous. Among a variety of embryological toxins that can induce HPE, inhibitors, and other pertubations of cholesterol biosynthesis have been shown to be important factors, most likely because cholesterol is required in the Sonic hedgehog signaling cascade. Decreased levels of maternal cholesterol during pregnancy increase...

  11. Low-set ears and pinna abnormalities

    ... because they do not affect hearing. However, sometimes cosmetic surgery is recommended. Skin tags may be tied off, ... 5 years old. More severe abnormalities may require surgery for cosmetic reasons as well as for function. Surgery to ...

  12. Abnormal Events for Emergency Trip in HANARO

    This report gathers abnormal events related to emergency trip of HANARO that happened during its operation over 10 years since the first criticality on February 1995. The collected examples will be utilized to the HANARO's operators as a useful guide

  13. The glycometabolism abnormality among schizophrenia patients

    吴小立

    2013-01-01

    Objective To explore the potential glycometabolism abnormality and the related factors of schizophrenia patients in China. Methods This cross-sectional study included 44 healthy controls(group 1) and 178 inpatient

  14. Amphibian abnormalities on National Wildlife Refuges

    US Fish and Wildlife Service, Department of the Interior — This fact sheet outlines a study done to 1 find the percentage of abnormal frogs and toads on the nations National Wildlife Refuges and 2 determine how the...

  15. Report to Congress on abnormal occurrences

    Section 208 of the Energy Reorganization Act of 1974 identifies an abnormal occurrence as an unscheduled incident or event that the Nuclear Regulatory Commission determines to be significant from the standpoint of public health or safety and requires a quarterly report of such events to be made to Congress. This report covers the period from April 1 through June 30, 1990. The report discusses six abnormal occurrences, none involving a nuclear power plant. There were five abnormal occurrences at NRC licensees: (1) deficiencies in brachytherapy program; (2) a radiation overexposure of a radiographer; (3) a medical diagnostic misadministration; (4) administration of iodine-131 to a lactating female with subsequent uptake by her infant; and (5) a medical therapy misadministration. An Agreement State (Arizona) reported an abnormal occurrence involving a medical diagnostic misadministration. The report also contains information that updates a previously reported occurrence

  16. Pinna abnormalities and low-set ears

    ... because they do not affect hearing. However, sometimes cosmetic surgery is recommended. Skin tags may be tied off, ... 5 years old. More severe abnormalities may require surgery for cosmetic reasons as well as for function. Surgery to ...

  17. Echocardiographic abnormalities in type IV mucopolysaccharidosis.

    John, R. M.; Hunter, D; Swanton, R. H.

    1990-01-01

    Cardiac involvement is well recognised in most forms of the mucopolysaccharidoses but there is poor documentation of abnormalities specific to Morquio's syndrome (type IV mucopolysaccharidosis). Ten patients with the classic form or type A Morquio's syndrome with a median age of 12.5 years underwent echocardiographic assessment. Abnormalities were detected in six (60%) cases with mitral valve involvement in five patients and aortic valve disease in four. One patient had severe mitral leaflet ...

  18. Abnormalities of gut vessels in Turner's syndrome.

    Reinhart, W H; Mordasini, C.; Stäubli, M.; Scheurer, U.

    1983-01-01

    We describe a 57-year-old patient with Turner's syndrome, iron deficiency anaemia and intestinal vascular abnormalities. Colonoscopy revealed 2 widely dilated, tortuous veins in the terminal ileum and several smaller ectatic veins and haemangioma-like malformations throughout the colon. Laparotomy for herniotomy showed only minimal vascular abnormalities of the serosal surface. Patients with Turner's syndrome and anaemia should be checked for these lesions by endoscopy, and conversely, in pat...

  19. Carbamazepine for acute psychosis with eeg abnormalities

    Ivković Maja; Damjanović Aleksandar; Marinković Dragan; Paunović Vladimir R.

    2004-01-01

    Aim. To investigate the efficacy of carbamazepine as adjuvant drug therapy in acute paranoid psychosis with associated EEG abnormalities, compared to sole antipsychotic treatment. Methods. Eleven medication-naive patients diagnosed with acute paranoid psychosis with associated EEG abnormalities were divided into two treatment groups: sole fluphenazine group, with flexible dosing of 5-10 mg/day (n=6), and carbamazepine group (n=5) with the addition of carbamazepine (600 mg/day) to fluphenazine...

  20. Remote disassembly of an abnormal multiplication system

    The method of abnormal multiplying systems remote disassembling is described. This method was worked through in actual operations as response to the nuclear accident at the RFNC-VNIIEF criticality test facility FKBN-2M on 17 June 1997. The abnormal assembly was a sphere of 235U (90%), surrounded by a copper reflector. The detailed information on the multiplying system disassembly operations could be of use to the experts at other institutions when they develop emergency response plans. (author)

  1. Holoprosencephaly due to Numeric Chromosome Abnormalities

    Solomon, Benjamin D.; Rosenbaum, Kenneth N.; Meck, Jeanne M.; Muenke, Maximilian

    2010-01-01

    Holoprosencephaly (HPE) is the most common malformation of the human forebrain. When a clinician identifies a patient with HPE, a routine chromosome analysis is often the first genetic test sent for laboratory analysis in order to assess for a structural or numerical chromosome anomaly. An abnormality of chromosome number is overall the most frequently identified etiology in a patient with HPE. These abnormalities include trisomy 13, trisomy 18, and triploidy, though several others have been ...

  2. Abnormal Head Position in Infantile Nystagmus Syndrome

    Susana Noval; Mar González-Manrique; José María Rodríguez-Del Valle; José María Rodríguez-Sánchez

    2011-01-01

    Infantile nystagmus is an involuntary, bilateral, conjugate, and rhythmic oscillation of the eyes which is present at birth or develops within the first 6 months of life. It may be pendular or jerk-like and, its intensity usually increases in lateral gaze, decreasing with convergence. Up to 64% of all patients with nystagmus also present strabismus, and even more patients have an abnormal head position. The abnormal head positions are more often horizontal, but they may also be vertical or ta...

  3. Breathing abnormalities in sleep in achondroplasia.

    Waters, K A; Everett, F; Sillence, D; Fagan, E.; Sullivan, C E

    1993-01-01

    Overnight sleep studies were performed in 20 subjects with achondroplasia to document further the respiratory abnormalities present in this group. Somatosensory evoked potentials (SEPs) were recorded in 19 of the subjects to screen for the presence of brainstem abnormalities, which are one of the potential aetiological mechanisms. Fifteen children aged 1 to 14 years, and five young adults, aged 20 to 31 years were included. All had upper airway obstruction and 15 (75%) had a pathological apno...

  4. Abnormal uterine bleeding: a clinicohistopathological analysis

    Anupamasuresh Y; Suresh YV; Prachi Jain*,

    2014-01-01

    Background: Abnormal uterine bleeding (AUB) is one of the most common problem for the patients and the gynecologists. It adversely effects on the quality of life and psychology of women. It is of special concern in developing country as it adds to the causes of anemia. Management of Abnormal Uterine Bleeding (AUB) is not complete without tissue diagnosis especially in perimenopausal and post-menopausal women. Histological characteristics of endometrial biopsy material as assessed by light mic...

  5. Evidence of portuguese stock market abnormal returns

    Duarte, Elisabete Mendes; Oliveira, Lisete Trindade

    2011-01-01

    According to the stock market efficiency theory, it is not possible to consistently beat the market. However, technical analysis is more and more spread as an efficient way to achieve abnormal returns. In fact there is evidence that momentum investing strategies provide abnormal returns in different stock markets, Jegadeesh, N. and Titman, S. (1993), George, T. and Hwang, C. (2004) and Du, D. (2009). In this work we study if like other markets, the Portuguese stock market also allows to obtai...

  6. Heterotaxy syndromes and abnormal bowel rotation

    Newman, Beverley [Stanford University, Lucile Packard Children' s Hospital, Department of Radiology, Stanford, CA (United States); Koppolu, Raji; Sylvester, Karl [Lucile Packard Children' s Hospital at Stanford, Department of Surgery, Stanford, CA (United States); Murphy, Daniel [Lucile Packard Children' s Hospital at Stanford, Department of Cardiology, Stanford, CA (United States)

    2014-05-15

    Bowel rotation abnormalities in heterotaxy are common. As more children survive cardiac surgery, the management of gastrointestinal abnormalities has become controversial. To evaluate imaging of malrotation in heterotaxy with surgical correlation and provide an algorithm for management. Imaging reports of heterotaxic children with upper gastrointestinal (UGI) and/or small bowel follow-through (SBFT) were reviewed. Subsequently, fluoroscopic images were re-reviewed in conjunction with CT/MR studies. The original reports and re-reviewed images were compared and correlated with surgical findings. Nineteen of 34 children with heterotaxy underwent UGI, 13/19 also had SBFT. In 15/19 reports, bowel rotation was called abnormal: 11 malrotation, 4 non-rotation, no cases of volvulus. Re-review, including CT (10/19) and MR (2/19), designated 17/19 (90%) as abnormal, 10 malrotation (abnormal bowel arrangement, narrow or uncertain length of mesentery) and 7 non-rotation (small bowel and colon on opposite sides plus low cecum with probable broad mesentery). The most useful CT/MR findings were absence of retroperitoneal duodenum in most abnormal cases and location of bowel, especially cecum. Abnormal orientation of mesenteric vessels suggested malrotation but was not universal. Nine children had elective bowel surgery; non-rotation was found in 4/9 and malrotation was found in 5/9, with discrepancies (non-rotation at surgery, malrotation on imaging) with 4 original interpretations and 1 re-review. We recommend routine, early UGI and SBFT studies once other, urgent clinical concerns have been stabilized, with elective laparoscopic surgery in abnormal or equivocal cases. Cross-sectional imaging, usually obtained for other reasons, can contribute diagnostically. Attempting to assess mesenteric width is important in differentiating non-rotation from malrotation and more accurately identifies appropriate surgical candidates. (orig.)

  7. Prevalence of asymptomatic urinary abnormalities among adolescents

    Mohamed Fouad

    2016-01-01

    Full Text Available To determine the prevalence of asymptomatic urinary abnormalities in adolescents, first morning clean mid-stream urine specimens were obtained from 2500 individuals and examined by dipstick and light microscopy. Adolescents with abnormal screening results were reexamined after two weeks and those who had abnormal results twice were subjected to systemic clinical examination and further clinical and laboratory investigations. Eight hundred and three (32.1% individuals had urinary abnormalities at the first screening, which significantly decreased to 345 (13.8% at the second screening, (P <0.001. Hematuria was the most common urinary abnormalities detected in 245 (9.8% adolescents who had persistent urine abnormalities; 228 (9.1% individuals had non glomerular hematuria. The hematuria was isolated in 150 (6% individuals, combined with leukocyturia in 83 (3.3% individuals, and combined with proteinuria in 12 (0.5% individuals. Leukocyturia was detected in 150 (6% of all studied adolescents; it was isolated in 39 (1.6% individuals and combined with proteinuria in 28 (1.1% of them. Asymp- tomatic bacteriuria was detected in 23 (0.9% of all studied adolescents; all the cases were females. Proteinuria was detected in 65 (2.6% of all the studied adolescents; 45 (1.8% indivi- duals had <0.5 g/day and twenty (0.8% individuals had 0.5-3 g/day. Asymptomatic urinary abnormalities were more common in males than females and adolescents from rural than urban areas (P <0.01 and (P <0.001, respectively. The present study found a high prevalence of asymptomatic urinary abnormalities among adolescents in our population.

  8. A Hierarchical Generative Framework of Language Processing: Linking Language Perception, Interpretation, and Production Abnormalities in Schizophrenia

    Brown, Meredith; Kuperberg, Gina R.

    2015-01-01

    Language and thought dysfunction are central to the schizophrenia syndrome. They are evident in the major symptoms of psychosis itself, particularly as disorganized language output (positive thought disorder) and auditory verbal hallucinations (AVHs), and they also manifest as abnormalities in both high-level semantic and contextual processing and low-level perception. However, the literatures characterizing these abnormalities have largely been separate and have sometimes provided mutually e...

  9. White matter abnormalities in tuberous sclerosis complex

    Griffiths, P.D. [Sheffield Univ. (United Kingdom). Academic Dept. of Radiology; Bolton, P. [Cambridge Univ. (United Kingdom). Section of Developmental Psychiatry; Verity, C. [Addenbrooke`s NHS Trust, Cambridge (United Kingdom). Dept. of Paediatric Radiology

    1998-09-01

    The aim of this study was to investigate and describe the range of white matter abnormalities in children with tuberous sclerosis complex by means of MR imaging. Material and Methods: A retrospective cross-sectional study was performed on the basis of MR imaging findings in 20 cases of tuberous sclerosis complex in children aged 17 years or younger. Results: White matter abnormalities were present in 19/20 (95%) cases of tuberous sclerosis complex. These were most frequently (19/20 cases) found in relation to cortical tubers in the supratentorial compartment. White matter abnormalities related to tubers were found in the cerebellum in 3/20 (15%) cases. White matter abnormalities described as radial migration lines were found in relation to 5 tubers in 3 (15%) children. In 4/20 (20%) cases, white matter abnormalities were found that were not related to cortical tubers. These areas had the appearance of white matter cysts in 3 cases and infarction in the fourth. In the latter case there was a definable event in the clinical history, supporting the diagnosis of stroke. Conclusion: A range of white matter abnormalities were found by MR imaging in tuberous sclerosis complex, the commonest being gliosis and hypomyelination related to cortical tubers. Radial migration lines were seen infrequently in relation to cortical tubers and these are thought to represent heterotopic glia and neurons along the expected path of cortical migration. (orig.)

  10. White matter abnormalities in tuberous sclerosis complex

    The aim of this study was to investigate and describe the range of white matter abnormalities in children with tuberous sclerosis complex by means of MR imaging. Material and Methods: A retrospective cross-sectional study was performed on the basis of MR imaging findings in 20 cases of tuberous sclerosis complex in children aged 17 years or younger. Results: White matter abnormalities were present in 19/20 (95%) cases of tuberous sclerosis complex. These were most frequently (19/20 cases) found in relation to cortical tubers in the supratentorial compartment. White matter abnormalities related to tubers were found in the cerebellum in 3/20 (15%) cases. White matter abnormalities described as radial migration lines were found in relation to 5 tubers in 3 (15%) children. In 4/20 (20%) cases, white matter abnormalities were found that were not related to cortical tubers. These areas had the appearance of white matter cysts in 3 cases and infarction in the fourth. In the latter case there was a definable event in the clinical history, supporting the diagnosis of stroke. Conclusion: A range of white matter abnormalities were found by MR imaging in tuberous sclerosis complex, the commonest being gliosis and hypomyelination related to cortical tubers. Radial migration lines were seen infrequently in relation to cortical tubers and these are thought to represent heterotopic glia and neurons along the expected path of cortical migration. (orig.)

  11. Chronic Treatment with Ang-(1-7 Reverses Abnormal Reactivity in the Corpus Cavernosum and Normalizes Diabetes-Induced Changes in the Protein Levels of ACE, ACE2, ROCK1, ROCK2 and Omega-Hydroxylase in a Rat Model of Type 1 Diabetes

    Mariam H. M. Yousif

    2014-01-01

    Full Text Available Angiotensin-(1-7 [Ang-(1-7] may have beneficial effects in diabetes mellitus-induced erectile dysfunction (DMIED but its molecular actions in the diabetic corpus cavernosum (CC are not known. We characterized the effects of diabetes and/or chronic in vivo administration of Ang-(1-7 on vascular reactivity in the rat corpus cavernosum (CC and on protein expression levels of potential downstream effectors of the renin-angiotensin-aldosterone system (RAAS such as angiotensin-converting enzyme (ACE, ACE2, Rho kinases 1 and 2 (ROCK1 and ROCK2, and omega-hydroxylase, the cytochrome-P450 enzyme that metabolizes arachidonic acid to form the vasoconstrictor, 20-hydroxyeicosatetraenoic acid. Streptozotocin-treated rats were chronicically administered Ang-(1-7 with or without A779, a Mas receptor antagonist, during weeks 4 to 6 of diabetes. Ang-(1-7 reversed diabetes-induced abnormal reactivity to vasoactive agents (endothelin-1, phenylepherine, and carbachol in the CC without correcting hyperglycemia. Six weeks of diabetes led to elevated ACE, ROCK1, ROCK 2, and omega-hydroxylase and a concomitant decrease in ACE2 protein expression levels that were normalized by Ang-(1-7 treatment but not upon coadministration of A779. These data are supportive of the notion that the beneficial effects of Ang-(1-7 in DMIED involve counterregulation of diabetes-induced changes in ACE, ACE2, Rho kinases, and omega-hydroxylase proteins in the diabetic CC via a Mas receptor-dependent mechanism.

  12. Chronic Treatment with Ang-(1-7) Reverses Abnormal Reactivity in the Corpus Cavernosum and Normalizes Diabetes-Induced Changes in the Protein Levels of ACE, ACE2, ROCK1, ROCK2 and Omega-Hydroxylase in a Rat Model of Type 1 Diabetes

    Yousif, Mariam H. M.; Makki, Batoul; El-Hashim, Ahmed Z.; Benter, Ibrahim F.

    2014-01-01

    Angiotensin-(1-7) [Ang-(1-7)] may have beneficial effects in diabetes mellitus-induced erectile dysfunction (DMIED) but its molecular actions in the diabetic corpus cavernosum (CC) are not known. We characterized the effects of diabetes and/or chronic in vivo administration of Ang-(1-7) on vascular reactivity in the rat corpus cavernosum (CC) and on protein expression levels of potential downstream effectors of the renin-angiotensin-aldosterone system (RAAS) such as angiotensin-converting enzyme (ACE), ACE2, Rho kinases 1 and 2 (ROCK1 and ROCK2), and omega-hydroxylase, the cytochrome-P450 enzyme that metabolizes arachidonic acid to form the vasoconstrictor, 20-hydroxyeicosatetraenoic acid. Streptozotocin-treated rats were chronicically administered Ang-(1-7) with or without A779, a Mas receptor antagonist, during weeks 4 to 6 of diabetes. Ang-(1-7) reversed diabetes-induced abnormal reactivity to vasoactive agents (endothelin-1, phenylepherine, and carbachol) in the CC without correcting hyperglycemia. Six weeks of diabetes led to elevated ACE, ROCK1, ROCK 2, and omega-hydroxylase and a concomitant decrease in ACE2 protein expression levels that were normalized by Ang-(1-7) treatment but not upon coadministration of A779. These data are supportive of the notion that the beneficial effects of Ang-(1-7) in DMIED involve counterregulation of diabetes-induced changes in ACE, ACE2, Rho kinases, and omega-hydroxylase proteins in the diabetic CC via a Mas receptor-dependent mechanism. PMID:25309930

  13. Abnormal sterol metabolism in holoprosencephaly.

    Haas, Dorothea; Muenke, Maximilian

    2010-02-15

    Holoprosencephaly (HPE) is the most common structural malformation of the developing forebrain in humans. The HPE phenotype is extremely variable and the etiology is heterogeneous. Among a variety of embryological toxins that can induce HPE, inhibitors, and other pertubations of cholesterol biosynthesis have been shown to be important factors, most likely because cholesterol is required in the Sonic hedgehog signaling cascade. Decreased levels of maternal cholesterol during pregnancy increase the risk for preterm delivery, but they are not associated with congenital malformations. However, if the fetus is affected by an inborn error of endogenous cholesterol synthesis, a reduction of maternal cholesterol concentration and cholesterol transport over the placenta aggravates the phenotypic expression. Exposure to lipophilic statins in early pregnancy may be associated with a substantial risk for structural CNS defects. PMID:20104605

  14. 儿童重症肺炎凝血指标与降钙素原变化及分析%The change of coagulation indicators and procalcitonin in children with severe pneumonia

    黄彩芝; 莫丽亚; 李爱国; 杨娟; 邓永超

    2015-01-01

    Objective To explore the changes in the levels of coagulation indicators and procalcitonin (PCT) in children with severe pneumonia. Methods A total of 76 children with severe pneumonia were selected and were divided into two groups according to the level of PCT, PCT<2.00 ng/ml group and PCT≥2.00 ng/ml group. Thirty healthy children were selected as normal controls. The levels of PCT, platelet counts (PLT), antithrombin-Ⅲ(AT-Ⅲ) activity and D-dimer (DD) were measured and compared among groups. Results Compared with control group, PCT, PLT and DD levels were signiifcantly higher and AT- Ⅲactivity was signiifcantly lower in severe pneumonia group (P<0.05). AT- Ⅲactivity and PLT were signiifcantly lower and DD level was signiifcantly higher in PCT≥2.00 ng/ml group than those in PCT<2.00 ng/ml group (P<0.05). The incidence of disseminated intravascular coagulation (DIC) in PCT≥2.00ng/ml group was signiifcantly higher than that in PCT<2.00ng/ml group (33.33%vs. 9.09%, correctedχ2=5.02, P=0.025). Conclusions There is dysfunction of coagulation in children with severe pneumonia. The higher level of PCT is, more obvious coagulation dysfunction is. The severe pneumonia children with high level of PCT are more likely to be complicated with disseminated inravascular coagulation.%目的:探讨重症肺炎患儿凝血指标与降钙素原(PCT)的变化。方法选取重症肺炎患儿76例,根据PCT升高的程度分为2组,PCT<2.00 ng/ml组和PCT≥2.00 ng/ml组;另选择30例健康儿童作为正常对照组。检测并分析比较各组的PCT、血小板计数(PLT)、抗凝血酶Ⅲ(AT-Ⅲ)活性和D-二聚体(DD)水平。结果与对照组比较,重症肺炎组PCT、PLT、DD水平明显升高,AT-Ⅲ活性明显降低,差异均有统计学意义(P<0.05);PCT≥2.00 ng/ml组的AT-Ⅲ活性和PLT水平相比PCT<2.00 ng/ml组更低,而DD水平更高,差异均有统计学意义(P<0.05);PCT≥2.00 ng/ml组的DIC发生率(33.33%)高于PCT<2.00 ng

  15. 降钙素原评估儿童创伤严重程度和创伤后脓毒症的研究%Procalcitonin as a Predictor of Trauma Severity and Post-traumatic Sepsis in Children

    刘少锋; 袁高品; 杨健; 何涛贞; 冯海欢; 刘敏

    2012-01-01

    Objective To determine the association of procalcitonin (PCT) with trauma severity and post-traumatic sepsis in children. Methods The blood samples of 30 children with acute trauma in a Pediatric unit were collected for four consecutive days. The levels of PCT, IL-6, CRP and WBC were measured. The pediatric trauma score (PTS) , length of stay in hospital, incidence of sepsis and clinical outcomes of the children were recorded. The value of PCT for predicting prognosis of children with trauma was compared with other inflammatory markers. Results Plasma PCT levels increased significantly in the patients in our study. Sepsis occurred in 23. 33% of the patients. The patients with sepsis had higher levels of PCT than those with and without systemic inflammatory response syndrome (SIRS) and the healthy controls (P<0. 05). The peak level of PCT emerged on day 2 after trauma. The plasma PCT levels were positively correlated with trauma severity. The level of PCT on day 2 was an independent predictor for post-trauma sepsis and SIRS. Conclusion Plasma PCT levels increase markedly in post-trauma children. Plasma PCT of day 2 after trauma is an independent predictor of post-traumatic sepsis and SIRS complications. There is a significant correlation between the severity of injury and plasma PCT.%目的 探讨血浆降钙素原(PCT)水平与儿童创伤严重程度和创伤后脓毒症的相关性.方法 检测30例严重创伤儿童创伤后第1、2、3、4d及23例正常对照相同时点的血浆PCT、白细胞介素-6(IL-6)、C-反应蛋白(CRP)、白细胞计数(WBC)水平,计算儿童创伤评分(pediatric trauma score,PTS),统计脓毒症发生率、住院时间,分析血浆PCT的变化特征,与其他指标对临床结局的预测价值进行比较.结果 与正常对照相比,30例创伤儿童血浆PCT水平均升高,23.33%(7例)患儿发生脓毒症,脓毒症组PCT水平高于全身炎症反应综合征(systemicinflammatory response syndrome,SIRS)组(7

  16. Sweating in Systemic Abnormalities: Uremia and Diabetes Mellitus.

    Murota, Hiroyuki

    2016-01-01

    Sweating disorders are sometimes observed in various systemic diseases that include genetic disorders, organ damage, metabolic impairment, autoimmune diseases, and neuropathic disorders. In these diseases, various symptoms such as autonomic failures, psychopathic disorders, abnormal skin innervation, and sweat gland dysfunction can interact with one another in diverse ways, resulting in impaired sweating. This review focuses on the influence of uremia (with or without hemodialysis) and diabetes mellitus on impaired sweating. Dialysis patients perspire less, but their sweat contains higher levels of uremic toxins than do healthy subjects. Neuropathic disorders in diabetes patients develop in relation to disease severity and can impair sweating. Physicians should consider the development of various problems, such as increased body temperature, dry skin, and increased susceptibility to infection, due to decreased sweating, as they are often found in these systemic abnormalities. PMID:27584963

  17. Abnormal Disturbance Mechanism of Sub-100 nm NAND Flash Memory

    Joo, Seok Jin; Yang, Hea Jong; Noh, Keum Hwan; Lee, Hee Gee; Woo, Won Sik; Lee, Joo Yeop; Lee, Min Kyu; Choi, Won Yol; Hwang, Kyoung Pil; Kim, Hyoung Seok; Sim, Sa Yong; Kim, Sook Kyoung; Chang, Hee Hyoun; Bae, Gi Hyoun

    2006-08-01

    An abnormal program disturbance mode was found in 32-string NAND flash memory which was fabricated with 0.09 μm complimentary metal-oxide-semiconductor shallow trench isolation (CMOS STI) process technology. This new disturbance mainly occurs in cells next to source select line (SSL) transistor and is not suppressed even when program bias is not applied. This is strongly related to the boosted channel bias level and the interface state which is located between the tunnel oxide and the silicon substrate. This unexpected program disturbance is a hot carrier program which results from the high electric field between the SSL transistor and its nearest cell and the leakage current to the boosted channel. The leakage current to the channel is due to the interface state of the SSL transistor, not the gate induced drain leakage (GIDL) effect. We present a brief model of this abnormal program disturbance mechanism.

  18. Ossification of the Achilles tendon: imaging abnormalities in 12 patients

    Ossification of the Achilles tendon is a rare clinical entity that is characterized by the presence of an ossific mass contained within the fibrocartilaginous substance of the tendon. Because the radiographic features of this condition have not been documented entirely and the magnetic resonance (MR) imaging findings have not been determined, a review of 16 affected tendons in 12 patients was performed in an attempt to characterize the imaging abnormalities associated with this process. MR imaging was performed in three Achilles tendons which demonstrated thickening of the tendons at the level of the ossifications and a lack of intratendinous signal abnormalities compatible with acute tendinitis. Signal intensity similar to that of bone marrow was present in the ossifications. (orig.)

  19. Ossification of the Achilles tendon: imaging abnormalities in 12 patients

    Yu, J.S. [Dept. of Radiology, Veterans Administration Medical Center, San Diego, CA (United States); Witte, D. [Dept. of Radiology, Veterans Administration Medical Center, San Diego, CA (United States); Resnick, D. [Dept. of Radiology, Veterans Administration Medical Center, San Diego, CA (United States); Pogue, W. [Dept. of Radiology, AMI Valley Medical Center, El Cajon, CA (United States)

    1994-02-01

    Ossification of the Achilles tendon is a rare clinical entity that is characterized by the presence of an ossific mass contained within the fibrocartilaginous substance of the tendon. Because the radiographic features of this condition have not been documented entirely and the magnetic resonance (MR) imaging findings have not been determined, a review of 16 affected tendons in 12 patients was performed in an attempt to characterize the imaging abnormalities associated with this process. MR imaging was performed in three Achilles tendons which demonstrated thickening of the tendons at the level of the ossifications and a lack of intratendinous signal abnormalities compatible with acute tendinitis. Signal intensity similar to that of bone marrow was present in the ossifications. (orig.)

  20. Clinical application of procalcitonin in critical ill patients%降钙素原在危重病中的应用价值

    邓水香(综述); 胡祖鹏(审校)

    2014-01-01

    降钙素原(Procalcitonin, PCT)是一项新的炎症指标,近年来PCT检测有助于感染性疾病的诊断和治疗,通过检测其血清浓度可早期诊断感染性疾病,评价感染的严重程度,指导用药及判断预后。本文简要介绍PCT在危重病中的临床应用。%As a new indicator of inflammation, procalcitonin (PCT) has been reported to be helpful in the diagnosis and treatment of infectious diseases in recent years . By detecting the concentration of serum PCT , it can help to diagnosis the infectious diseases at early period , evaluate the severity of infection, guide the medication and indicate the prognosis .In this paper, the main purpose was to introduce the clinical application of PCT in critically ill patients .

  1. Analysis of serum procalcitonin detection in neonatal septicemia%新生儿败血症血清降钙素原检测的结果分析

    杨清梅; 李朝辉

    2013-01-01

    目的 评价血清降钙素原 ( procalcitonin,PCT)检测在诊断新生儿败血症中的应用价值.方法 对所研究对象进行血清 PCT检测和血培养,并对结果进行分析.结果 败血症患儿中 PCT阳性率高于血培养阳性率;与对照组相比,败血症组 PCT 阳性率差异有统计学意义 ( P<0.05),PCT对诊断新生儿败血症的灵敏度为 82.1%,特异度为90%.结论 PCT检测可以作为早期诊断新生儿败血症快速灵敏的参考指标.

  2. [Use of procalcitonine in intensive care units: comparison of semi quantitative PCT-Q Brahms assay with automated PCT-Kryptor assay].

    Schuch, Géraldine; Duc-Marchand, Catherine; Venet, Cyrille; Mann, Hubert; Tixier, Anne; Bionda, Clara

    2011-01-01

    Procalcitonine (PCT) is recognized as a major and specific biomarker in diagnosis of bacterial infection. Used early in sepsis, it allows immediate administration of antibiotics and monitoring its effectiveness. Confronted on systemic inflammation response syndrom (SIRS), physicians must react quickly and effectively to evaluate bacterial infection and sepsis. The objective of this study was to compare analytical and clinical performances of semi-quantitative PCT-Q assay (Brahms) with quantitative and automated assay such on Kryptor (Brahms). Fifty blood samples of intensive care patients were compared. The analytical performance observed with PCT-Q assay is accurate: linear ratio kappa of 0.912 (95% CI 0.61, 0.97) and a good correlation between these techniques (p < 0.0001) (MedCalc software) were observed. Three discordances were observed and confirm the difficulties of reading for values close to 0.5 ng/mL. For these patients, PCT result showed its interest to discriminate local infection of a sepsis, to stop antibiotherapy with broad spectrum and to consolidate a therapeutic effectiveness in multi-visceral failure context. The semi-quantitative assay seems adapted for a fast and reliable evaluation of PCT in a general-purpose laboratory, not requiring neither dedicated analyzer, nor complex technicality but a control of the visual evaluation of results. It could be used for diagnosis of sepsis without monitoring precisely therapeutic follow-up. PMID:22123565

  3. Procalcitonin as a Serum Biomarker for Differentiation of Bacterial Meningitis From Viral Meningitis in Children: Evidence From a Meta-Analysis.

    Henry, Brandon Michael; Roy, Joyeeta; Ramakrishnan, Piravin Kumar; Vikse, Jens; Tomaszewski, Krzysztof A; Walocha, Jerzy A

    2016-07-01

    Several studies have explored the use of serum procalcitonin (PCT) in differentiating between bacterial and viral etiologies in children with suspected meningitis. We pooled these studies into a meta-analysis to determine the PCT diagnostic accuracy. All major databases were searched through March 2015. No date or language restrictions were applied. Eight studies (n = 616 pediatric patients) were included. Serum PCT assay was found to be very accurate for differentiating the etiology of pediatric meningitis with pooled sensitivity and specificity of 0.96 (95% CI = 0.92-0.98) and 0.89 (95% CI = 0.86-0.92), respectively. The pooled positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio (DOR), and area under the curve (AUC) for PCT were 7.5 (95% CI = 5.6-10.1), 0.08(95% CI = 0.04-0.14), 142.3 (95% CI = 59.5-340.4), and 0.97 (SE = 0.01), respectively. In 6 studies, PCT was found to be superior than CRP, whose DOR was only 16.7 (95%CI = 8.8-31.7). Our meta-analysis demonstrates that serum PCT assay is a highly accurate and powerful test for rapidly differentiating between bacterial and viral meningitis in children. PMID:26378091

  4. Combined use of myeloid-related protein 8/14 and procalcitonin as diagnostic markers for acute allograft rejection in kidney transplantation recipients.

    Jung, Da-Yeon; Park, Jae Berm; Lee, Eun-Na; Lee, Hyun-Ah; Joh, Jae-Won; Kwon, Choon Hyuck; Ki, Chang-Seok; Lee, Soo-Youn; Kim, Sung-Joo

    2008-02-01

    The myeloid-related proteins 8 and 14 exist as a dimeric complex (MRP 8/14) and serve as early and highly specific markers for inflammatory processes, such as allograft rejection and non-viral (bacterial or fungal) infections. An elevated procalcitonin (PCT) concentration in serum also serves as a diagnostic indicator of non-viral infection. Therefore, by measuring both MRP 8/14 and PCT serum concentrations, one may be able to distinguish between acute allograft rejection and non-viral infections in non-rejection transplant recipients. Here, we investigated whether MRP 8/14 and PCT can function as prognostic (Study I) or diagnostic (Study II) markers for allograft rejection in renal transplant recipients. In Study I, the serum concentrations of MRP 8/14 and PCT during the first 2 weeks after transplantation did not differ between patients who did and did not suffer organ rejection within 1 year post-transplantation; these findings suggest that the MRP 8/14 and PCT parameters are not valid prognostic markers. However, in Study II, patients with acute rejection or non-rejection/non-viral infection groups displayed a significant increase in serum MRP 8/14 concentration, and non-rejection patients with non-viral infections only had elevation in the PCT serum concentrations. These results indicate that the combined use of MRP 8/14 and PCT serum concentrations can allow one to distinguish between allograft rejection and other inflammatory processes, such as infection. PMID:18158120

  5. Tall gastrodis tuber combined with antiepileptic drugs repairs abnormal perfusion foci in focal epilepsy

    Weimin Wang; Zhenyu Fan; Yongqin Zhang; Yuxia Yang; Yaqing Liu; Xiaoli Dang; Wenjun Song; Yinping Wu; Jiang Ye

    2013-01-01

    One hundred patients with focal epilepsy were recruited for the present study and their seizures controlled with antiepileptic drugs. The patients then orally received a capsule of tall gastrodis tuber powder, a traditional Chinese drug, and underwent single photon emission computed tomography, long-term electroencephalogram, and CT/MRI. Blood drug levels were monitored throughout the study. Before treatment with tall gastrodis tuber, 35 of the 100 cases had abnormal CT/MRI scans; 79 cases had abnormal single photon emission computed tomography images; 86 cases had abnormal electroencephalogram; and a total of 146 abnormal perfusion foci were observed across the 100 subjects. After treatment, the number of patients with normal single photon emission computed tomography images increased by 12; normal electroencephalogram was observed in an additional 27 cases and the number of patients with epileptiform discharge decreased by 29 (34% of 86); the total number of abnormal perfusion foci decreased by 52 (36%) and changes in abnormal foci were visible in 65 patients. These changes indicate that the administration of tall gastrodis tuber in combination with antiepileptic drugs repairs abnormal perfusion foci in patients with focal epilepsy. Our results demonstrate that traditional Chinese drugs can repair abnormal perfusion foci and, as such, are a promising new pathway in the treatment of focal epilepsy.

  6. Incidental paranasal sinuses abnormalities in pediatric patients using computed tomography of the head and orbits

    Objective: To evaluate the prevalence and appearance of incidental paranasal sinuses abnormalities in children with no clinical evidence of rhino sinusitis using CT scans. Materials and methods: CT scans of the head or orbits of children between 0 and 18 years of age performed due to problems not related to rhino sinusitis were studied. Results: Sixty-four children were included (mean age 5.7 years; standard deviation = 3.9). Incidental sinuses abnormalities were found in 46 cases (72%). In most cases the abnormalities were mild (25/46) and mucosal thickening was the most common finding. Complete opacification and fluid levels occurred in 12 children. More than one cavity was affected in 33 patients and abnormalities were most frequently seen in maxillary sinuses, followed by ethmoid sinuses. Bilateral and symmetric findings were common. The prevalence and intensity of abnormalities were higher in children below three years of age. Conclusion: Incidental abnormalities are highly prevalent and tend to be mild in children without symptoms of rhino sinusitis. The most prevalent abnormality was mucosal thickening. Moderate and severe abnormalities occur in children below three years of age. (author)

  7. Abnormal movement preparation in task-specific focal hand dystonia.

    Jakob Jankowski

    Full Text Available Electrophysiological and behavioral studies in primary dystonia suggest abnormalities during movement preparation, but this crucial phase preceding movement onset has not yet been studied specifically with functional magnetic resonance imaging (fMRI. To identify abnormalities in brain activation during movement preparation, we used event-related fMRI to analyze behaviorally unimpaired sequential finger movements in 18 patients with task-specific focal hand dystonia (FHD and 18 healthy subjects. Patients and controls executed self-initiated or externally cued prelearnt four-digit sequential movements using either right or left hands. In FHD patients, motor performance of the sequential finger task was not associated with task-related dystonic posturing and their activation levels during motor execution were highly comparable with controls. On the other hand reduced activation was observed during movement preparation in the FHD patients in left premotor cortex / precentral gyrus for all conditions, and for self-initiation additionally in supplementary motor area, left mid-insula and anterior putamen, independent of effector side. Findings argue for abnormalities of early stages of motor control in FHD, manifesting during movement preparation. Since deficits map to regions involved in the coding of motor programs, we propose that task-specific dystonia is characterized by abnormalities during recruitment of motor programs: these do not manifest at the behavioral level during simple automated movements, however, errors in motor programs of complex movements established by extensive practice (a core feature of FHD, trigger the inappropriate movement patterns observed in task-specific dystonia.

  8. OPHTHALMOLOGIC ABNORMALITIES IN CHILDREN WITH IMPAIRED HEARING

    Inderjit

    2014-02-01

    Full Text Available AIM: To determine the nature of ophthalmologic abnormalities in severe and profound grades of hearing impaired children and to treat visual impairment if any at the earliest . MATERIAL AND METHODS: Study was conducted on100 children in the age group of 5 - 14 years with severe and profound hearing loss visiting outpatient department of Ram Lal Eye and ENT hospital Govt. Medical College Amritsar and subjected to detailed ophthalmological examination. RESULTS: 100 children in the age group 5 - 14 years with hearing impairment were enrolled for t he study , 68 had profound and 32 had severe hearing loss . Visual disorders were found to be as high as 71%. Highest percentage was seen in children aged 7 years. Majority of them (50% had refractive error. Out of these 50 children , 28(56% had myopia , 10 (20% hypermetropia and 12(24% had astigmatism . The other ophthalmic abnormalities in our study were conjunctivitis 14(19.71% , fundus abnormalities and squint 11(15.49% , blepharitis 5 (7.04% , vitamin A deficiency 6 (8.04% , amblyopia 8 (11.26% , pupil disorder 3 (4.22% , cataract 3 (4.22% and heterochromia iridis 7 (9.85%. CONCLUSION : The high prevalence of ophthalmic abnormalities in deaf children mandate screening them for possible ophthalmic abnormalities. Early diagnosis and correction of visual d isturbances would go a long way in social and professional performance of these children.

  9. Carbamazepine for acute psychosis with eeg abnormalities

    Ivković Maja

    2004-01-01

    Full Text Available Aim. To investigate the efficacy of carbamazepine as adjuvant drug therapy in acute paranoid psychosis with associated EEG abnormalities, compared to sole antipsychotic treatment. Methods. Eleven medication-naive patients diagnosed with acute paranoid psychosis with associated EEG abnormalities were divided into two treatment groups: sole fluphenazine group, with flexible dosing of 5-10 mg/day (n=6, and carbamazepine group (n=5 with the addition of carbamazepine (600 mg/day to fluphenazine treatment. Clinical Global Impression (CGI, Brief Psychiatric Rating Scale (BPRS, Scale for the Assessment of Negative Symptoms (SANS, and EEG were assessed on the baseline and after 6 weeks of treatment. Paired and two-tailed t-tests were used for statistical significance. Results. All the patients showed significant improvement of mental state after 6 weeks of treatment with no significant differences in CGI, BPRS, and total SANS scores in relation to the therapy with carbamazepine. Nevertheless, after 6 weeks of the treatment, EEG findings were significantly better in carbamazepine group, in relation to the findings from the onset of the treatment, as well as in comparison to sole fluphenazine group. Conclusion. Although carbamazepine stabilized abnormal brain electrical activities it seemed that the associated EEG abnormalities were not significant for acute psychosis observed. These preliminary results suggested that there was no convincing evidence that carbamazepine was efficient as the augmentation of antipsychotic treatment for patients with both acute paranoid psychosis and EEG abnormalities.

  10. Dysmorphometrics: the modelling of morphological abnormalities

    Claes Peter

    2012-02-01

    Full Text Available Abstract Background The study of typical morphological variations using quantitative, morphometric descriptors has always interested biologists in general. However, unusual examples of form, such as abnormalities are often encountered in biomedical sciences. Despite the long history of morphometrics, the means to identify and quantify such unusual form differences remains limited. Methods A theoretical concept, called dysmorphometrics, is introduced augmenting current geometric morphometrics with a focus on identifying and modelling form abnormalities. Dysmorphometrics applies the paradigm of detecting form differences as outliers compared to an appropriate norm. To achieve this, the likelihood formulation of landmark superimpositions is extended with outlier processes explicitly introducing a latent variable coding for abnormalities. A tractable solution to this augmented superimposition problem is obtained using Expectation-Maximization. The topography of detected abnormalities is encoded in a dysmorphogram. Results We demonstrate the use of dysmorphometrics to measure abrupt changes in time, asymmetry and discordancy in a set of human faces presenting with facial abnormalities. Conclusion The results clearly illustrate the unique power to reveal unusual form differences given only normative data with clear applications in both biomedical practice & research.

  11. Report on Congress on abnormal occurrences

    Section 208 of the energy Reorganization Act of 1974 identifies an abnormal occurrence as an unscheduled incident or event that the Nuclear Regulatory Commission determines to be significant from the standpoint of public health or safety and requires a quarterly report of such events to be made to Congress. This report covers the period from January 1 through March 31, 1991. The report discusses six abnormal occurrences, none of which involved a nuclear power plant. Five of the events occurred at NRC-licensed facilities: one involved a significant degradation of plant safety at a nuclear fuel cycle facility, one involved a medical diagnostic misadministration, and three involved medical therapy misadministrations. An Agreement State (Arizona) reported one abnormal occurrence that involved medical therapy misadministrations

  12. Cone photopigment bleaching abnormalities in diabetes.

    Elsner, A E; Burns, S A; Lobes, L A; Doft, B H

    1987-04-01

    We have used a color-matching technique to obtain estimates of the optical density of cone photopigments as a function of retinal illuminance in patients with insulin-dependent diabetes mellitus (IDDM). We found that the half-bleach illuminance of some patients is abnormally high. That is, it takes more light to bleach an equivalent amount of photopigment in these patients. Since low illuminance color matches for these patients are normal, this implies that these patients have normal amounts of photopigment, but the photopigment is not bleaching normally. This result clearly points to abnormalities in the outer retina of these diabetic patients. The most likely causes of this abnormality are either decreases in the ability of the cones to absorb light, or an increased rate of regeneration of the cone photopigments. PMID:3557875

  13. Advances in understanding paternally transmitted Chromosomal Abnormalities

    Marchetti, F; Sloter, E; Wyrobek, A J

    2001-03-01

    Multicolor FISH has been adapted for detecting the major types of chromosomal abnormalities in human sperm including aneuploidies for clinically-relevant chromosomes, chromosomal aberrations including breaks and rearrangements, and other numerical abnormalities. The various sperm FISH assays have been used to evaluate healthy men, men of advanced age, and men who have received mutagenic cancer therapy. The mouse has also been used as a model to investigate the mechanism of paternally transmitted genetic damage. Sperm FISH for the mouse has been used to detect chromosomally abnormal mouse sperm, while the PAINT/DAPI analysis of mouse zygotes has been used to evaluate the types of chromosomal defects that can be paternally transmitted to the embryo and their effects on embryonic development.

  14. 血清降钙素原测定在儿童全身炎症反应综合征的临床应用价值%Clinical value of procalcitonin in treatment of systematic inflammatory response syndrome among children

    肖菲; 江丽丹; 郝金斗

    2015-01-01

    Objective To assess the clinical value of procalcitonin ( PCT) in the treatment of systematic inflammatory response syn-drome ( SIRS) among children. Methods A total of 177 children with SIRS in our ward were divided into routine group and PCT-guided treatment group ( PCT group) randomly. The children in routine group were treated with antibiotics according to the guideline for antibiotics use. Meanwhile, whether to use antibiotics of the children in PCT group was decided by serum level of PCT. Antibiotics were used when PCT level was more than 0. 50 ng/mL and antibiotics were not used when PCT level was less than 0. 50 ng/mL. Inflammatory markers, time of an-tibiotics use and inpatient days were compared between the two groups. Results There was no significant difference in white blood cell, C reaction protein(CRP) and clinical effects of patients in PCT group after antibiotics use between PCT group and routine group(P>0. 05). However, days of antibiotics use and inpatient stay in PCT group were significant shorter than in routine group(P0.05);但PCT组的抗菌药物使用率、使用时间及住院时间明显短于常规组,差异有统计学意义(P<0.05)。结论动态监测患儿PCT水平,对于减少抗菌药物使用及缩短住院时间具有重要的临床指导意义。

  15. Hemorheological abnormalities in human arterial hypertension

    Lo Presti, Rosalia; Hopps, Eugenia; Caimi, Gregorio

    2014-05-01

    Blood rheology is impaired in hypertensive patients. The alteration involves blood and plasma viscosity, and the erythrocyte behaviour is often abnormal. The hemorheological pattern appears to be related to some pathophysiological mechanisms of hypertension and to organ damage, in particular left ventricular hypertrophy and myocardial ischemia. Abnormalities have been observed in erythrocyte membrane fluidity, explored by fluorescence spectroscopy and electron spin resonance. This may be relevant for red cell flow in microvessels and oxygen delivery to tissues. Although blood viscosity is not a direct target of antihypertensive therapy, the rheological properties of blood play a role in the pathophysiology of arterial hypertension and its vascular complications.

  16. Nonpathologizing trauma interventions in abnormal psychology courses.

    Hoover, Stephanie M; Luchner, Andrew F; Pickett, Rachel F

    2016-01-01

    Because abnormal psychology courses presuppose a focus on pathological human functioning, nonpathologizing interventions within these classes are particularly powerful and can reach survivors, bystanders, and perpetrators. Interventions are needed to improve the social response to trauma on college campuses. By applying psychodynamic and feminist multicultural theory, instructors can deliver nonpathologizing interventions about trauma and trauma response within these classes. We recommend class-based interventions with the following aims: (a) intentionally using nonpathologizing language, (b) normalizing trauma responses, (c) subjectively defining trauma, (d) challenging secondary victimization, and (e) questioning the delineation of abnormal and normal. The recommendations promote implications for instructor self-reflection, therapy interventions, and future research. PMID:26460794

  17. Association of periodontal status with liver abnormalities and metabolic syndrome.

    Ahmad, Aisyah; Furuta, Michiko; Shinagawa, Takashi; Takeuchi, Kenji; Takeshita, Toru; Shimazaki, Yoshihiro; Yamashita, Yoshihisa

    2015-01-01

    Although an association between periodontal status and liver abnormalities has been reported, it has not been described in relation to metabolic syndrome (MetS), which often coexists with non-alcoholic fatty liver disease. We examined the association of a combination of liver abnormality and MetS with periodontal condition in Japanese adults, based on the level of alcohol consumption. In 2008, 4,207 males aged 45.4 ± 8.9 years and 1,270 females aged 45.9 ± 9.7 years had annual workplace health check-ups at a company in Japan. Periodontal status was represented as periodontal pocket depth at the mesio-buccal and mid-buccal sites for all teeth. Alanine aminotransferase (ALT), and metabolic components were examined. Multiple linear regression analysis showed a significant association between deep pocket depth and the coexistence of elevated ALT and MetS in males with low alcohol consumption. Females showed no such relationship. In conclusion, the association between periodontal condition and the combination of elevated ALT and MetS was confirmed in males. That is, a clear association between liver abnormalities and periodontal condition was seen in male subjects with no or low alcohol consumption and MetS, providing new insights into the connection between liver function and periodontal health. PMID:26666857

  18. Induced abnormality in Mir- and earth grown super dwarf wheat

    Bubenheim, D. L.; Stieber, J.; Campbell, W. F.; Salisbury, F. B.; Levinski, M.; Sytchev, V.; Pdolsky, I.; Chernova, L.

    Super-dwarf wheat grown on the Mir space station using the Svet ``Greenhouse'' exhibited morphological, metabolic and reproductive abnormalities compared with Earth-grown wheat. Of prominent importance were the abnormalities associated with reproductive ontogeny and the total absence of seed formation on Mir. Changes in the apical meristem associated with transition from the vegetative phase to floral initiation and development of the reproductive spike were all typical of `Super-Dwarf' wheat up to the point of anthesis. Observation of ruptured anthers from the Mir-grown plants revealed what appeared to be normally developed pollen. These pollen gains, however, contained only one nuclei, while normal viable pollen is tri-nucleate. A potentially important difference in the flight experiment, compared with ground reference studies, was the presence of a high level of atmospheric ethylene (1,200 ppb). Ground studies conducted by exposing `Super-Dwarf' wheat to ethylene just prior to anthesis resulted in manifestation of the same abnormalities observed in the space flight samples.

  19. Drop Analysis in Infants with Bacterial Pneumonia in the Diagnosis of Procalcitonin Detection and Blood Culture%降钙素原检测与血培养在婴幼儿细菌性肺炎诊断中的作用分析

    陈贵英

    2015-01-01

    Objective To compare the procalcitonin and blood culture results in the diagnosis of bacterial pneumonia in infants.Methods Choose 36 cases of infants with bacterial pneumonia,fasting blood,for procalcitonin detection,blood culture,the comparison results.Results Procalcitonin blood culture positive rate was 52.78%;the total positive rate was 25%.Conclusion In the diagnosis of infantile bacterial pneumonia,procalcitonin has more advantage.%目的对比降钙素原与血培养在婴幼儿细菌性肺炎诊断中效果。方法选取婴幼儿细菌性肺炎患儿36例,抽取空腹静脉血,行降钙素原、血培养检测,对比结果。结果降钙素原阳性率为52.78%;血培养总阳性率为25.00%。结论在婴幼儿细菌性肺炎诊断中,降钙素原检测具有更大的优势。

  20. Urogenital abnormalities and atresia of the gastrointestinal tract

    Dobanovački Dušanka

    2005-01-01

    Full Text Available Introduction. The goal of the study was to investigate the frequency of urogenital congenital abnormalities among atresias of the digestive system and analyze fetal maldevelopment. The study also deals with gastrointestinal and urogenital embryology. Material and methods. This retrospektive study analyzed the clinical status of 55 new-borns admitted to the Pediatric Surgery Clinic in Novi Sad due to atresia of the gastrointestinal tract during 1995-2003. All atresias were classified at primordial gut levels (foregut, midgut and hindgut. The incidence of associated abnormalities, especially urogenital, was analyzed. Diagnostic procedures included standard methods: clinical investigation, ultrasound, native and contrast medium radiography, etc. Results. Results showed that urogenital anomalies were present in 21 (38.18% newborns with gastrointestinal atresia. Foregut atresia was diagnosed in 14 newborns and it was associated with urogenital congenital anomalies in 9 (64.28% newborns. Midgut atresias were found in 15 patients and in 4 (22.22% they were associated with urogenital anomalies. Hindgut atresias were established in 23 and in 8 (34.78% cases they were associated with urogenital anomalies. Discussion and conclusions. It was confirmed that foregut atresias are commonly accompanied by associated abnormalities. That is why the fourth gestational week is important when both gastroinestinal and urogenital systems are developed. When midgut differentiates into its own derivates, the frequency of congenital anomalies decreases for a short period, and then increases again during foregut development (seventh and eighth gestational weeks. There were no information on environmental teratogenic factors in maternal history. These abnormalities may be explained by complex urorectal development and separation of two systems. .

  1. Computerized analysis of abnormal asymmetry in digital chest radiographs: Evaluation of potential utility

    Armato, Samuel G; Giger, Maryellen L.; MacMahon, Heber

    1999-01-01

    The purpose of this study was to develop and test a computerized method for the fully automated analysis of abnormal asymmetry in digital posteroanterior (PA) chest radiographs. An automated lung segmentation method was used to identify the aerated lung regions in 600 chest radiographs. Minimal apriori lung morphology information was required for this gray-level thresholding-based segmentation. Consequently, segmentation was applicable to grossly abnormal cases. The relative areas of segmente...

  2. Influence of genetic abnormalities on semen quality and male fertility: A four-year prospective study

    Fadlalla Elfateh; Ruixue Wang; Zhihong Zhang; Yuting Jiang; Shuang Chen; Ruizhi Liu

    2014-01-01

    Background: Wide range of disorders ranging from genetic disorders to coital difficulties can influence male fertility. In this regard, genetic factors are highlighted as the most frequent, contributed to 10-15%, of male infertility causes. Objective: To investigate the influence of genetic abnormalities on semen quality and reproductive hormone levels of infertile men from Northeast China. Materials and Methods: 2034 infertile men including 691 patients with abnormal sperm parameters were in...

  3. Amplitude of Low Frequency Fluctuation Abnormalities in Adolescents with Online Gaming Addiction

    Yuan, Kai; Jin, Chenwang; Cheng, Ping; Yang, Xuejuan; DONG, tao; Bi, Yanzhi; Xing, Lihong; von Deneen, Karen M.; Yu, Dahua; Liu, Junyu; Liang, Jun; CHENG, TINGTING; Qin, Wei; Tian, Jie

    2013-01-01

    The majority of previous neuroimaging studies have demonstrated both structural and task-related functional abnormalities in adolescents with online gaming addiction (OGA). However, few functional magnetic resonance imaging (fMRI) studies focused on the regional intensity of spontaneous fluctuations in blood oxygen level-dependent (BOLD) during the resting state and fewer studies investigated the relationship between the abnormal resting-state properties and the impaired cognitive control abi...

  4. Brain White Matter Abnormality in a Newborn Infant with Congenital Adrenal Hyperplasia

    Kaga, Akimune; Saito-hakoda, Akiko; Uematsu, Mitsugu; Kamimura, Miki; Kanno, Junko; Kure, Shigeo; Fujiwara, Ikuma

    2013-01-01

    Several studies have described brain white matter abnormalities on magnetic resonance imaging (MRI) in children and adults with congenital adrenal hyperplasia (CAH), while the brain MRI findings of newborn infants with CAH have not been clarified. We report a newborn boy with CAH who presented brain white matter abnormality on MRI. He was diagnosed as having salt-wasting CAH with a high 17-OHP level at neonatal screening and was initially treated with hydrocortisone at 8 days of age. On day 1...

  5. Vitamin D and Risk of Neuroimaging Abnormalities.

    Littlejohns, Thomas J; Kos, Katarina; Henley, William E; Lang, Iain A; Annweiler, Cedric; Beauchet, Olivier; Chaves, Paulo H M; Kestenbaum, Bryan R; Kuller, Lewis H; Langa, Kenneth M; Lopez, Oscar L; Llewellyn, David J

    2016-01-01

    Vitamin D deficiency has been linked with an increased risk of incident all-cause dementia and Alzheimer's disease. The aim of the current study was to explore the potential mechanisms underlying these associations by determining whether low vitamin D concentrations are associated with the development of incident cerebrovascular and neurodegenerative neuroimaging abnormalities. The population consisted of 1,658 participants aged ≥65 years from the US-based Cardiovascular Health Study who were free from prevalent cardiovascular disease, stroke and dementia at baseline in 1992-93. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were determined by liquid chromatography-tandem mass spectrometry from blood samples collected at baseline. The first MRI scan was conducted between 1991-1994 and the second MRI scan was conducted between 1997-1999. Change in white matter grade, ventricular grade and presence of infarcts between MRI scan one and two were used to define neuroimaging abnormalities. During a mean follow-up of 5.0 years, serum 25(OH)D status was not significantly associated with the development of any neuroimaging abnormalities. Using logistic regression models, the multivariate adjusted odds ratios (95% confidence interval) for worsening white matter grade in participants who were severely 25(OH)D deficient (vitamin D concentrations could not be shown to be associated with the development of cerebrovascular or neurodegenerative neuroimaging abnormalities in Cardiovascular Health Study participants. PMID:27166613

  6. Craniofacial abnormalities among patients with Edwards Syndrome

    Rafael Fabiano M. Rosa

    2013-09-01

    Full Text Available OBJECTIVE To determine the frequency and types of craniofacial abnormalities observed in patients with trisomy 18 or Edwards syndrome (ES. METHODS This descriptive and retrospective study of a case series included all patients diagnosed with ES in a Clinical Genetics Service of a reference hospital in Southern Brazil from 1975 to 2008. The results of the karyotypic analysis, along with clinical data, were collected from medical records. RESULTS: The sample consisted of 50 patients, of which 66% were female. The median age at first evaluation was 14 days. Regarding the karyotypes, full trisomy of chromosome 18 was the main alteration (90%. Mosaicism was observed in 10%. The main craniofacial abnormalities were: microretrognathia (76%, abnormalities of the ear helix/dysplastic ears (70%, prominent occiput (52%, posteriorly rotated (46% and low set ears (44%, and short palpebral fissures/blepharophimosis (46%. Other uncommon - but relevant - abnormalities included: microtia (18%, orofacial clefts (12%, preauricular tags (10%, facial palsy (4%, encephalocele (4%, absence of external auditory canal (2% and asymmetric face (2%. One patient had an initial suspicion of oculo-auriculo-vertebral spectrum (OAVS or Goldenhar syndrome. CONCLUSIONS: Despite the literature description of a characteristic clinical presentation for ES, craniofacial alterations may be variable among these patients. The OAVS findings in this sample are noteworthy. The association of ES with OAVS has been reported once in the literature.

  7. Psychology Faculty Perceptions of Abnormal Psychology Textbooks

    Rapport, Zachary

    2011-01-01

    The problem. The purpose of the current study was to investigate the perceptions and opinions of psychology professors regarding the accuracy and inclusiveness of abnormal psychology textbooks. It sought answers from psychology professors to the following questions: (1) What are the expectations of the psychology faculty at a private university of…

  8. Dynamic Abnormal Grain Growth in Refractory Metals

    Noell, Philip J.; Taleff, Eric M.

    2015-11-01

    High-temperature plastic deformation of the body-centered cubic (BCC) refractory metals Mo and Ta can initiate and propagate abnormal grains at significantly lower temperatures and faster rates than is possible by static annealing alone. This discovery reveals a new and potentially important aspect of abnormal grain growth (AGG) phenomena. The process of AGG during plastic deformation at elevated temperatures, termed dynamic abnormal grain growth (DAGG), was observed at homologous temperatures between 0.52 and 0.72 in both Mo and Ta sheet materials; these temperatures are much lower than those for previous observations of AGG in these materials during static annealing. DAGG was used to repeatedly grow single crystals several centimeters in length. Investigations to date have produced a basic understanding of the conditions that lead to DAGG and how DAGG is affected by microstructure in BCC refractory metals. The current state of understanding for DAGG is reviewed in this paper. Attention is given to the roles of temperature, plastic strain, boundary mobility and preexisting microstructure. DAGG is considered for its potential useful applications in solid-state crystal growth and its possibly detrimental role in creating undesired abnormal grains during thermomechanical processing.

  9. Gastric emptying abnormal in duodenal ulcer

    To investigate the possibility that an abnormality of gastric emptying exists in duodenal ulcer and to determine if such an abnormality persists after ulcer healing, scintigraphic gastric emptying measurements were undertaken in 16 duodenal ulcer patients before, during, and after therapy with cimetidine; in 12 patients with pernicious anemia, and in 12 control subjects. No difference was detected in the rate or pattern of gastric emptying in duodenal ulcer patients before and after ulcer healing with cimetidine compared with controls, but emptying of the solid component of the test meal was more rapid during treatment with the drug. Comparison of emptying patterns obtained in duodenal ulcer subjects during and after cimetidine treatment with those obtained in pernicious anemia patients and controls revealed a similar relationship that was characterized by a tendency for reduction in the normal differentiation between the emptying of solid and liquid from the stomach. The similarity in emptying patterns in these groups of subjects suggests that gastric emptying of solids may be influenced by changes in the volume of gastric secretion. The failure to detect an abnormality of gastric emptying in duodenal ulcer subjects before and after ulcer healing calls into question the widespread belief that abnormally rapid gastric emptying is a feature with pathogenetic significance in duodenal ulcer disease

  10. Reversible splenial abnormality in hypoglycemic encephalopathy

    Kim, Ji Hyun; Choi, Jeong Yoon; Koh, Seong-Beom [Korea University School of Medicine, Department of Neurology, Guro Hospital, Seoul (Korea); Lee, Younghen [Korea University School of Medicine, Department of Radiology, Ansan Hospital, Ansan City (Korea)

    2007-03-15

    Lesions involving the splenium of the corpus callosum (SCC) have been rarely reported in cases of hypoglycemic brain injury. We identified signal abnormalities in the SCC in three adult patients with hypoglycemic encephalopathy by using diffusion-weighted imaging (DWI) on a 1.5-T MR scanner. Repeat DWI was performed in all patients following a marked clinical improvement, and MR angiography and routine MRI were also performed. We examined each patient's detailed medical history and blood laboratory tests in order to exclude other conditions causing similar SCC abnormalities. Initial DWI was performed during which each patient showed altered mental status that was attributed to profound hypoglycemia. We observed an identical pattern of DWI abnormality characterized by high signals in the SCC with apparent diffusion coefficient reductions that were reversed completely within several days following appropriate correction of hypoglycemia. T2-weighted or FLAIR images also showed no residual lesion in the SCC and MR angiography was normal in all patients. These case reports suggest that the SCC should be added to the list of selective vulnerability to hypoglycemia and that hypoglycemia, in turn, be included in the differential diagnosis of reversible SCC abnormalities. (orig.)

  11. Reversible splenial abnormality in hypoglycemic encephalopathy

    Lesions involving the splenium of the corpus callosum (SCC) have been rarely reported in cases of hypoglycemic brain injury. We identified signal abnormalities in the SCC in three adult patients with hypoglycemic encephalopathy by using diffusion-weighted imaging (DWI) on a 1.5-T MR scanner. Repeat DWI was performed in all patients following a marked clinical improvement, and MR angiography and routine MRI were also performed. We examined each patient's detailed medical history and blood laboratory tests in order to exclude other conditions causing similar SCC abnormalities. Initial DWI was performed during which each patient showed altered mental status that was attributed to profound hypoglycemia. We observed an identical pattern of DWI abnormality characterized by high signals in the SCC with apparent diffusion coefficient reductions that were reversed completely within several days following appropriate correction of hypoglycemia. T2-weighted or FLAIR images also showed no residual lesion in the SCC and MR angiography was normal in all patients. These case reports suggest that the SCC should be added to the list of selective vulnerability to hypoglycemia and that hypoglycemia, in turn, be included in the differential diagnosis of reversible SCC abnormalities. (orig.)

  12. Comparison of the results between quantitative procalcitonin detection and blood culture%血清降钙素原定量检测与血培养结果的比较

    王凯飞; 沈定霞; 刘朝军; 叶丽艳; 王磊利; 张有江

    2012-01-01

    目的 探讨降钙素原(PCT)定量检测在血流感染患者中的临床应用价值.方法 采用回顾性研究,对解放军总医院1066例患者同时送检血液培养和PCT检测的结果进行分析,其中有效结果1010例.比较血培养结果与血清PCT浓度的关系及PCT浓度在革兰阴性细菌、革兰阳性细菌及假丝酵母菌之间的差异.并且对33例进行过多次PCT检测的血培养阳性患者预后进行了分析.三组间PCT值差异比较采用Mann-Whitney U检验;死亡率比较采用Fisher's精确概率法.结果 血培养阴性患者PCT为0.37(0.11 ~1.67) μg/L.血培养阳性患者PCT水平为2.24(0.57~11.59)μg/L;PCT在革兰阴性细菌、革兰阳性细菌及假丝酵母菌中的阳性率分别为86.6%、72.0%及75.7%.在33例多次PCT检测的血培养阳性患者中,PCT进行性减低者预后较好,PCT均值>5 μg/L者预后较差.结论 定量检测PCT可作为快速排除和诊断血流感染的辅助检测手段.观察PCT变化趋势对预后判断有一定的参考价值.%Objective To evaluate the application value of the quantitative procalcitonin (PCT) test in bloodstream infection.Methods Of 1066 patients with blood culture and PCT detection were collected in our hospital,retrospectively,1010 were effective cases.The relationship between blood culture results and serum PCT levels was investigated.PCT levels in gram-negative bacterial infection,gram-positive bacterial infection and candidiasis were compared.The prognosis of 33 blood culture positive patients with repeated PCT detection results were analyzed.Mann-Whitney U test was used to compare the PCT value among the three groups,and Fisher' s test was used to compare the death rate among the three groups.Results In the patients with negative blood culture results,the median of PCT was 0.37 (0.11 - 1.67) μg/L.But in the patients with positive blood culture results,the median of PCT were 2.24(0.57 -11.59) μg/L The positive rate of PCT in gram

  13. Noise effects on the complex patterns of abnormal heartbeats

    Schulte-Frohlinde, V.; Ashkenazy, Y.; Ivanov, P. C.; Glass, L.; Goldberger, A. L.; Stanley, H. E.

    2001-01-01

    Patients at high risk for sudden death often exhibit complex heart rhythms in which abnormal heartbeats are interspersed with normal heartbeats. We analyze such a complex rhythm in a single patient over a 12-h period and show that the rhythm can be described by a theoretical model consisting of two interacting oscillators with stochastic elements. By varying the magnitude of the noise, we show that for an intermediate level of noise, the model gives best agreement with key statistical features of the dynamics.

  14. 血清降钙素原在早期诊断和监控脓毒症中的临床应用评价%Clinical value of procalcitonin in early diagnosis and monitoring of patients with sepsis

    邢豫宾; 戴路明

    2008-01-01

    Procalcitonin (PCT) is an inflammatory indicator which has more specificity over conventional inflammatory markers and C-reactive protein (CRP) in the diagnosis of sepsis. PCT concentration is positive correlated with the severity of inflammation and monitored condition of disease, estimated prognosis and observed curative effects. The thesis reviews the physiological characteristics, diagnosis value of PCT and compares with the other inflammatory markers,for example CRP,so that values scientifically PCT in the early diagnosis and mornitoring of the patients with sepsis.%血清降钙素原(procalcitonin,PCT)作为一个炎症指标,较传统炎症指标和C反应蛋白(CRP)在诊断脓毒症方面有较高的特异性.PCT浓度和炎症的严重程度呈正相关,可以监测脓毒症的病情变化、估计预后和观察疗效.本文对PCT的生理特性、诊断地位,并和常用炎症指标(如CRP)作进一步分析比较,来科学评估PCT对脓毒症的早期诊断和监控价值.

  15. Procalcitonin and strategy of antibacterial treatment in acute exacerbation of chronic obstructive pulmonary disease%降钙素原和慢性阻塞性肺疾病急性加重期抗生素治疗

    王岚; 蔡柏蔷

    2008-01-01

    慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary diseases,AECOPD)抗生素治疗仍存争议.最新研究表明在AECOPD中,动态监测降钙素原(procalcitonin,PCT)水平对抗生素的应用有明确的指导作用,可以减少不必要的抗生素应用,缩短应用时间,防止耐药.PCT指导策略在被建议成为全球AECOPD抗生素治疗方案之前,尚面临几个关键问题有待解决.%The role of antimicrobial in acute exacerbation of chronic obstructive pulmonary diseases (AECOPD) remains controversial.Recent reports have shown that the dynamic determination for procalcitonin(PCT)could instruct antibiotic use,decrease unnecessary exposure time,shorten the course of treatment,and prevent antibiotic resistance in AECOPD.But,some important questions remain before PCT guided therapy can be recommended as a worldwide standard approach to AECOPD antimicrobial management.

  16. 细菌感染及感染程度与血清降钙素原(Procalcitonin PCT)的相关性分析

    陈思宇

    2011-01-01

    目的:探讨血清降钙素原(Procalcitonin PCT)与细菌感染的相关性。方法:采用罗氏Cobas E411电化学发光仪测定患者血清PCT含量,比较在不同致病菌感染中PCT含量的差异,以及脓毒症组与非脓毒症组间的差异。结果:以PCT≥0.5ng/ml为阳性阈值。PCT阳性率为88.24%(15/17);而不同致病菌所致感染组问PCT含量无显著性差异(P〉0.05);以PCT≥2.0ng/ml为脓毒症的阳性闽值,脓毒症患者与非脓毒症患者血清PCT含量有显著性差异(P〈0.01)。PCT对脓毒症的临床诊断灵敏度为81.81%(9/11),特异性为100%(6/6)。结论:血清PCT是鉴别细菌性感染引发脓毒血症快捷、敏感、准确的监测手段,优于白细胞计数,但不能够判断为何种细菌感染。

  17. COMPARATIVE STUDY OF LRINEC SCORE: PROCALCITONIN AND LRINEC SCORE: C-REACTIVE PROTEIN IN PREDICTING DURATION OF HOSPITAL STAY AND SEVERITY IN NECROTISING FASCIITIS

    Manoj Gowda

    2016-06-01

    Full Text Available BACKGROUND Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC score is a simple laboratory tool used to distinguish between Necrotizing Soft-Tissue Infections (NSTI and other soft-tissue infections. A LRINEC score of ≥6 is considered as denoting a high risk of necrotizing fasciitis. A very high LRINEC score might also be associated with mortality and other outcomes of patients with NSTI. METHODS A review of the medical charts of patients was carried out in a tertiary academic Centre. All adult patients with necrotizing softtissue infections from 2010 to 2011 were selected and LRINEC scores were calculated for each patient. The enrolled patients had sufficient information to determine the LRINEC score. Serum Procalcitonin (PCT was used in place of serum C-Reactive Protein (CRP to improve the efficacy of LRINEC score. Serum PCT was considered positive if the value was >0.56 ng/mL. LRINEC score-PCT and LRINEC score-CRP were compared in predicting duration of hospital stay and severity. RESULTS In this study of 50 patients 64% of them were males, majority of the patients were between the age group of 40-80 years. LRINEC score PCT had better predictability for severity and duration of hospital stay when compared to LRINEC score with CRP. Pearson correlation of LRINEC score PCT vs LRINEC score, CRP was statistically significant with LRINEC score, PCT having 30% of patients with longer duration of hospital stay in comparison to LRINEC score CRP which had 12%. CONCLUSION LRINEC score: PCT had better probability in predicting severity and duration of hospital stay when compared to LRINEC score: CRP.

  18. Procalcitonin and BISAP score versus c-reactive protein and APACHE II score in early assessment of severity and outcome of acute pancreatitis

    Bezmarević Mihailo

    2012-01-01

    Full Text Available Background/Aim. Early assessment of severity and continuous monitoring of patients are the key factors for adequate treatment of acute pancreatitis (AP. The aim of this study was to determine the value of procalcitonin (PCT and Bedside Index for Severity in Acute Pancreatitis (BISAP scoring system as prognostic markers in early stages of AP with comparison to other established indicators such as Creactive protein (CRP and Acute Physiology and Chronic Health Evaluation (APACHE II score. Methods. This prospective study included 51 patients (29 with severe AP. In the first 24 h of admission in all patients the APACHE II score and BISAP score, CRP and PCT serum concentrations were determined. The values of PCT serum concentrations and BISAP score were compared with values of CRP serum concentrations and APACHE II score, in relation to the severity and outcome of the disease. Results. Values of PCT, CRP, BISAP score and APACHE II score, measured at 24 h of admission, were significantly elevated in patients with severe form of the disease. In predicting severity of AP at 24 h of admission, sensitivity and specificity of the BISAP score were 74% and 59%, respectively, APACHE II score 89% and 69%, respectively, CRP 75% and 86%, respectively, and PCT 86% and 63%, respectively. It was found that PCT is highly significant predictor of the disease outcome (p < 0,001. Conclusion. In early assessment of AP severity, PCT has better predictive value than CRP, and similar to the APACHE II score. APACHE II score is a stronger predictor of the disease severity than BISAP score. PCT is a good predictor of AP outcome.

  19. How abnormal is the behaviour of captive, zoo-living chimpanzees?

    Lucy P Birkett

    Full Text Available BACKGROUND: Many captive chimpanzees (Pan troglodytes show a variety of serious behavioural abnormalities, some of which have been considered as possible signs of compromised mental health. The provision of environmental enrichments aimed at reducing the performance of abnormal behaviours is increasing the norm, with the housing of individuals in (semi-natural social groups thought to be the most successful of these. Only a few quantitative studies of abnormal behaviour have been conducted, however, particularly for the captive population held in zoological collections. Consequently, a clear picture of the level of abnormal behaviour in zoo-living chimpanzees is lacking. METHODS: We present preliminary findings from a detailed observational study of the behaviour of 40 socially-housed zoo-living chimpanzees from six collections in the United States of America and the United Kingdom. We determined the prevalence, diversity, frequency, and duration of abnormal behaviour from 1200 hours of continuous behavioural data collected by focal animal sampling. RESULTS, CONCLUSION AND SIGNIFICANCE: Our overall finding was that abnormal behaviour was present in all sampled individuals across six independent groups of zoo-living chimpanzees, despite the differences between these groups in size, composition, housing, etc. We found substantial variation between individuals in the frequency and duration of abnormal behaviour, but all individuals engaged in at least some abnormal behaviour and variation across individuals could not be explained by sex, age, rearing history or background (defined as prior housing conditions. Our data support a conclusion that, while most behaviour of zoo-living chimpanzees is 'normal' in that it is typical of their wild counterparts, abnormal behaviour is endemic in this population despite enrichment efforts. We suggest there is an urgent need to understand how the chimpanzee mind copes with captivity, an issue with both

  20. CT abnormality in multiple sclerosis analysis based on 28 probable cases and correlation with clinical manifestations

    In order to investigate the occurrence and nature of CT abnormality and its correlation with clinical manifestations in multiple sclerosis, 34 CT records obtained from 28 consecutive patients with probable multiple sclerosis were reviewed. Forty-six percent of all cases showed abnormal CT. Dilatation of cortical sulci was found in 39%; dilatation of the lateral ventricle in 36%; dilatation of prepontine or cerebello-pontine cistern and the fourth ventricle, suggesting brainstem atrophy, in 18%; dilatation of cerebellar sulci, superior cerebellar cistern and cisterna magna, suggesting cerebellar atrophy, in 11%. Low density area was found in the cerebral hemisphere in 11% of cases. Contrast enhancement, performed on 25 CT records, did not show any change. There was no correlation between CT abnormality and duration of the illness. Although abnormal CT tended to occur more frequently during exacerbations and chronic stable state than during remissions, the difference was not statistically significant. CT abnormalities suggesting brainstem atrophy, cerebellar atrophy or plaques were found exclusively during exacerbations and chronic stable state. The occurrence of CT abnormalities was not significantly different among various clinical forms which were classified based on clinically estimated sites of lesion, except that abnormal CT tended to occur less frequently in cases classified as the optic-spinal form. It is noteworthy that cerebral cortical atrophy and/or dilatation of the lateral ventricle were found in 31% of cases who did not show any clinical sign of cerebral involvement. There was a statistically significant correlation between CT abnormalities and levels of clinical disability. Eighty percent of the bedridden or severely disabled patients showed abnormal CT, in contrast with only 29% of those with moderate, slight or no disability. (author)