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Sample records for abnormal laboratory results

  1. Abnormal Cervical Cancer Screening Test Results

    ... AQ FREQUENTLY ASKED QUESTIONS FAQ187 GYNECOLOGIC PROBLEMS Abnormal Cervical Cancer Screening Test Results • What is cervical cancer screening? • What causes abnormal cervical cancer screening test ...

  2. The prevalence of abnormal results of annual investigations among diabetic patients with different risk factors

    The basic theme of this study was to promote the use of risk approach and encourage selectively in requesting laboratory investigations. The objective was to estimate the proportion of abnormal results obtained from routinely requested annual investigations among the whole study population and the odds ratio of abnormal test results among patients with certain risk factors. A total of 459 diabetic patients aged 12 years and over, attending the primary care clinics of a university hospitals in Riyadh, Saudi Arabia, were included in this study. In this cross-sectional study, analysis of associations between patient's demographic characteristics and clinical findings (independent variables), and the results of annual investigations were conducted. A multiple logistic regression analysis was carried to identify certain independent variables associated with abnormal investigations. The proportion of patients who had abnormal electrocardiogram (ECG) was 23%, chest X-ray (CXR) 26% and liver function test (LFT) 9%. High systolic blood pressure (BP) and age were found to be important determinants of abnormal ECG and CXR. Patients who had high systolic BP (>140mm Hg) were found to be 2.39 times more likely to have abnormal ECG (OR=2.39), and their odds ratio of abnormal CXR was 2.33. Furthermore, for each 10-year increment in age, there was a 43% increased likelihood of abnormal ECG and 295 increase of abnormal CXR. Smokers were nine times more likely to have abnormal LFT (OR=9.26, 95% CI=2.29 tp 37.5). The disease duration and obesity were not found to have and independent association with the possibility of having abnormal results. The study results led to some tentative suggestions on guidelines for clinicians in their decision either to request annual investigations for all diabetic patients, or to restrict some investigations to certain group of patients. This was discussed and compared with the findings from the literature and other authorities recommendations. (author)

  3. [The "incorrect" laboratory result. II: Common misinterpretations of laboratory results].

    Thiery, J; Fiedler, G M

    2004-04-01

    In the second part of our review the most frequent misinterpretations of laboratory results in the daily clinical practise are discussed. Special attention has been given to frequent misinterpretations in the analysis of electrolytes, enzymes and hormones in plasma/serum (pseudohyperkalemia, macroenzymes, macroprolactinemia). Misinterpretations of the testing of blood gases, serum glucose, lipid concentrations, and calcium are described in greater detail. In addition, potential errors in the urinanalysis and the importance of adequate sampling of blood specimens for coagulation testing are described. The hematological results can be misinterpreted in the presence of EDTA-induced pseudothrombocytenia and of irregular immunoglobulines. Immunological methods themselves can lead to misinterpretations of the laboratory result, e. g. caused by the high dose hook effect and interferences in the presence of rheumatoid factor or HAMA. Finally clinical relevant errors in the therapeutic drug monitoring are discussed which are associated with the limited specificity of the antibodies in the commonly used immunological tests. PMID:15151138

  4. Abnormalities Occurring during Female Gametophyte Development Result in the Diversity of Abnormal Embryo Sacs and Leads to Abnormal Fertilization in indicaljaponica Hybrids in Rice

    Yu-Xiang Zeng; Chao-Yue Hu; Yong-Gen Lu; Jin-Quan Li; Xiang-Dong Liu

    2009-01-01

    Embryo sac abortion is one of the major masons for sterility in indicaljaponica hybrids In rice. To clarify the causal mechanism of embryo sac abortion, we studied the female gametophyte development in two indicaljaponica hybrids via an eosin B staining procedure for embryo sac scanning using confocal laser scanning microscope. Different types of abnormalities occurred during megasporogenesis and megagamatogenesis were demonstrated. The earliest abnormality was observed in the megasporocyte. A lot of the chalazal-most megaspores were degenerated before the mono-nucleate embryo sac stage. Disordered positioning of nucleus and abnormal nucallus tissue were characteristics of the abnormal female gametes from the mono-nucleate to four-nucleate embryo sac stages. The abnormalities that occurred from the early stage of the eight-nucleate embryo sac development to the mature embryo sac stage were characterized by smaller sizes and wrinkled antipodals. Asynchronous nuclear migration, abnormal positioning of nucleus, and degeneration of egg apparatus were also found at the eight-nucleate embryo sac stage. The abnormalities that occurred during female gametophyte development resulted in five major types of abnormal embryo sacs. These abnormal embryo sacs led to abnormal fertilization. Hand pollination using normal pollens on the spikelets during anthesis showed that normal pollens could not exclude the effect of abnormal embryo sac on seed setting.

  5. Spondylodiscitis after Cervical Nucleoplasty without Any Abnormal Laboratory Findings

    Lee, Seung Jun; Choi, Eun Joo; Nahm, Francis Sahngun

    2013-01-01

    Infective spondylodiscitis is a rare complication that can occur after interventional spinal procedures, of which symptoms are usually back pain and fever. Early diagnosis of infective spondylodiscitis is critical to start antibiotics and to improve prognosis. Laboratory examinations including complet blood cell count (CBC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) are conventional tools for the early detection of infectious spondylitis. However, we experienced infec...

  6. Long-Term Evaluation of Abnormal Behavior in Adult Ex-laboratory Chimpanzees (Pan troglodytes Following Re-socialization

    Karl Crailsheim

    2013-01-01

    Full Text Available Adverse rearing conditions are considered a major factor in the development of abnormal behavior. We investigated the overall levels, the prevalence and the diversity of abnormal behavior of 18 adult former laboratory chimpanzees, who spent about 20 years single caged, over a two-year period following re-socialization. According to the onset of deprivation, the individuals were classified as early deprived (EDs, mean: 1.2 years or late deprived (LDs, mean: 3.6 years. The results are based on 187.5 hours of scan sampling distributed over three sample periods: subsequent to re-socialization and during the first and second year of group-living. While the overall levels and the diversity of abnormal behavior remained stable over time in this study population, the amplifying effects of age at onset of deprivation became apparent as the overall levels of abnormal behavior of EDs were far above those of LDs in the first and second year of group-living, but not immediately after re-socialization. The most prevalent abnormal behaviors, including eating disorders and self-directed behaviors, however, varied in their occurrence within subjects across the periods. Most important, the significance of social companionship became obvious as the most severe forms of abnormal behavior, such as dissociative and self-injurious behaviors declined.

  7. Assessing the prevalence distribution of abnormal laboratory tests in patients with simple febrile seizure

    Parsa Yousefichaijan

    2015-01-01

    Full Text Available Introduction: Febrile seizure is an important issue in pediatric practice. Even some pediatricians do not have a proper approach to febrile seizure, making the sick child undergo complex laboratory tests or invasive procedures or even long-term treatment with anticonvulsant drugs. In spite of multiple studies, many controversies have still remained about the significance of febrile seizure. The goal of this study is to assess the prevalence distribution of routinely requested laboratory tests results in simple febrile seizure. Materials and Methods: In a descriptive study, 549 patients with simple febrile seizure were studied. The routine lab tests including complete blood count, electrolyte, urine analysis, and cerebrospinal fluid (CSF analysis had already been performed for all patients and the results had been recorded in their medical data. These results were collected and statistically analyzed through SPSS software. Results: About 58.7% of our cases were male. Most of the cases were 12-24 months old and the mean body temperature of them was 38.2°C. 99.3% of blood sugar tests, 98% of blood calcium tests, 100% and 99.5% of sodium, and potassium tests, respectively, 100% of blood creatinine, 96.9% of blood urea nitrogen, and 99.1% of urine analysis tests were normal. CSF analysis was done in only 49 cases and the results were normal in all of them. Conclusion: The percentage of abnormal laboratory test results was not statistically significant in febrile seizure and shows that performing all these tests in all patients with simple febrile seizure as routine is not necessary.

  8. Lopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalities

    Mario Ferreira Peixoto

    2011-06-01

    Full Text Available OBJECTIVES: To describe laboratory abnormalities among HIV-infected women and their infants with standard and increased lopinavir/ritonavir (LPV/r dosing during the third trimester of pregnancy. METHODS: We evaluated data on pregnant women from NISDI cohorts (2002-2009 enrolled in Brazil, who received at least 28 days of LPV/r during the third pregnancy trimester and gave birth to singleton infants. RESULTS: 164 women received LPV/r standard dosing [(798/198 or 800/200 mg/day (Group 1] and 70 increased dosing [(> 800/200 mg/day (Group 2]. Group 1 was more likely to have advanced clinical disease and to use ARVs for treatment, and less likely to have CD4 counts > 500 cells/mm³. Mean plasma viral load was higher in Group 2. There were statistically significant, but not clinically meaningful, differences between groups in mean AST, ALT, cholesterol, and triglycerides. The proportion of women with Grade 3 or 4 adverse events was very low, with no statistically significant differences between groups in severe adverse events related to ALT, AST, total bilirubin, cholesterol, or triglycerides. There were statistically significant, but not clinically meaningful, differences between infant groups in ALT and creatinine. The proportion of infants with Grade 3 or 4 adverse events was very low, and there were no statistically significant differences in severe adverse events related to ALT, AST, BUN, or creatinine. CONCLUSION: The proportions of women and infants with severe laboratory adverse events were very low. Increased LPV/r dosing during the third trimester of pregnancy appears to be safe for HIV-infected women and their infants.

  9. Real causes of apparent abnormal results in heavy ion reactions

    Mandaglio G.

    2015-01-01

    Full Text Available We study the effect of the static characteristics of nuclei and dynamics of the nucleus-nucleus interaction in the capture stage of reaction, in the competition between quasifission and complete fusion processes, as well as the angular momentum dependence of the competition between fission and evaporation processes along the de-excitation cascade of the compound nucleus. The results calculated for the mass-asymmetric and less mass-asymmetric reactions in the entrance channel are analyzed in order to investigate the role of the dynamical effects on the yields of the evaporation residue nuclei. We also discuss about uncertainties at the extraction of such relevant physical quantities as Γn/Γtot ratio or also excitation functions from the experimental results due to the not always realistic assumptions in the treatment and analysis of the detected events. This procedure can lead to large ambiguity when the complete fusion process is strongly hindered or when the fast fission contribution is large. We emphasize that a refined multiparameter model of the reaction dynamics as well as a more detailed and checked data analysis are strongly needed in heavy-ion collisions.

  10. Response to an Abnormal Ovarian Cancer Screening Test Result: Test of the Social Cognitive Processing and Cognitive Social Health Information Processing Models

    Andrykowski, Michael A.; Pavlik, Edward J.

    2010-01-01

    All cancer screening tests produce a proportion of abnormal results requiring follow-up. Consequently, the cancer screening setting is a natural laboratory for examining psychological and behavioral response to a threatening health-related event. This study tested hypotheses derived from the Social Cognitive Processing and Cognitive-Social Health Information Processing models in trying to understand response to an abnormal ovarian cancer (OC) screening test result. Women (n=278) receiving an ...

  11. Drug-Related Hospital Visits and Admissions Associated with Laboratory or Physiologic Abnormalities-A Systematic-Review.

    Kerry Wilbur

    Full Text Available Countless studies have demonstrated that many emergency-room visits and hospital admissions are drug-related and that a significant proportion of these drug-related visits (DRVs are preventable. It has not been previously studied which DRVs could be prevented through enhanced monitoring of therapy. The objective of the study was to determine the incidence of DRVs attributed to laboratory or physiologic abnormalities. Three authors independently performed comprehensive searches in relevant health care databases using pre-determined search terms. Articles discussing DRV associated with poisoning, substance abuse, or studied among existing in-patient populations were excluded. Study country, year, sample, design, duration, DRV identification method, proportion of DRVs associated with laboratory or physiologic abnormalities and associated medications were extracted. The three authors independently assessed selected relevant articles according to the Strengthening the reporting of observational studies in epidemiology (STROBE as applicable according to the studies' methodology. The initial literature search yielded a total of 1,524 articles of which 30 articles meeting inclusion criteria and reporting sufficient laboratory or physiologic data were included in the overall analysis. Half employed prospective methodologies, which included both chart review and patient interview; however, the overwhelming majority of identified studies assessed only adverse drug reactions (ADRs as a drug-related cause for DRV. The mean (range prevalence of DRVs found in all studies was 15.4% (0.44%-66.7% of which an association with laboratory or physiologic abnormalities could be attributed to a mean (range of 29.4% (4.3%-78.1% of cases. Most laboratory-associated DRVs could be linked to immunosuppressant, antineoplastic, anticoagulant and diabetes therapy, while physiologic-associated DRVs were attributed to cardiovascular therapies and NSAIDs. Significant proportions

  12. Mining association rules between abnormal health examination results and outpatient medical records.

    Chao Huang, Yi

    2013-01-01

    Currently, interpretation of health examination reports relies primarily on the physician's own experience. If health screening data could be integrated with outpatient medical records to uncover correlations between disease and abnormal test results, the physician could benefit from having additional reference resources for medical examination report interpretation and clinic diagnosis. This study used the medical database of a regional hospital in Taiwan to illustrate how association rules can be found between abnormal health examination results and outpatient illnesses. The rules can help to build up a disease-prevention knowledge database that assists healthcare providers in follow-up treatment and prevention. Furthermore, this study proposes a new algorithm, the data cutting and sorting method, or DCSM, in place of the traditional Apriori algorithm. DCSM significantly improves the mining performance of Apriori by reducing the time to scan health examination and outpatient medical records, both of which are databases of immense sizes. PMID:23736654

  13. Prevalence of renal and hepatobiliary disease, laboratory abnormalities, and potentially toxic medication exposures among persons with COPD

    Mapel DW

    2013-03-01

    Full Text Available Douglas W Mapel,1 Jenõ P Marton21Lovelace Clinic Foundation, Albuquerque, New Mexico, NM, USA; 2Health Economics and Outcomes Research, Pfizer Inc, New York, NY, USABackground: The purpose of this study was to describe the prevalence of renal and hepatic disease, related laboratory abnormalities, and potentially hepatotoxic and nephrotoxic medication use in a population-based cohort of persons with chronic obstructive pulmonary disease (COPD.Methods: This was a retrospective case-control cohort analysis of COPD patients enrolled in one regional health system for at least 12 months during a 36-month study period (n = 2284. Each COPD patient was matched by age and gender to up to three persons not diagnosed with COPD (n = 5959.Results: The mean age for cases and controls was 70.3 years, and 52.5% were women. The COPD cohort had significantly higher prevalences (cases/100 of acute, chronic, and unspecified renal failure as compared with controls (1.40 versus 0.59, 2.89 versus 0.79, and 1.09 versus 0.44, respectively. Among the cases, 31.3% had at least one renal or urinary tract diagnosis during the study period, as compared with 21.1% of controls. COPD cases also had more gallbladder disease (2.76 versus 1.63 and pancreatic disease (1.40 versus 0.60, but not hepatic disease. COPD patients were more likely to have at least one serum creatinine level (5.1 versus 2.1 or liver aspartate aminotransferase level (4.5 versus 2.7 that was more than twice the upper limit of normal. COPD patients had prescription fills for an average of 17.6 potentially nephrotoxic and 27.4 hepatotoxic drugs during the study period, as compared with 13.6 and 19.9 for the controls (P value for all comparisons < 0.01.Conclusion: COPD patients have a substantially increased prevalence of renal, gallbladder, and pancreatic diseases, as well as abnormal renal and hepatic laboratory values, but not diagnosed liver disease. COPD patients are also more likely to be prescribed

  14. Experimental Results in DIS from Jefferson Laboratory

    Sebastian Kuhn

    2009-10-01

    We are summarizing the experimental program of Jefferson Lab (Thomas Jefferson National Accelerator Facility in Newport News, VA) in deep inelastic electron scattering. We show recent results and discuss future plans for both the present 6 GeV era and the 12 GeV energy-upgraded facility.

  15. Correlation of bleeding pattern with endometrial histopathologic results in perimenopausal women with abnormal uterine bleeding

    Zehra Yilmaz

    2015-06-01

    Full Text Available Background: Abnormal Uterine Bleeding (AUB is referred as bleeding outside of normal menstruation pattern and it is the most common gynecological problem for women of all ages. This study was evaluated the correlation of menstrual bleeding patterns and endometrial histopathological findings in perimenopausal women. Methods: This study was done on perimenopausal aged women presented with AUB for the last 6 months at a gynecology clinic of a tertiary medical center. Only the patients with isolated endometrial causes of AUB were selected for study. A total of 313 cases were included in the study. Abnormal bleeding patterns of the patients were recorded and endometrial sampling was performed to all women. AUB was classified as menorrhagia, metrorrhagia, menometrorrhagia, polymenorrhea, intermenstrual bleeding, and histopathological findings were classified as Proliferative Endometrium (PE, Secretory Endometrium (SE, Disordered Proliferative Pattern (DPP, Endometrial Polyp (EP, Chronic Endometritis (CE, Endometrial Hyperplasia (EH, and Endometrial Adenocarcinoma (CA. Results: The most common bleeding pattern was menorrhagia (45.0% and the most common histopathological finding was PE+SE (52.0% in our study. PE+SE and endometrial hyperplasia without atypia were found more common in menorrhagia group. The most histopathological findings were found PE+SE in menometrorrhagia and polymenorrhea group (P 0.05. Conclusions: We concluded that although menometrorrhagia and polymenorrhea were significantly more associated with PE+SE, intermenstrual bleeding was significantly more associated with EP and CE. It is noteworthy that endometrial hyperplasia without atypia is significantly higher in patients with menorrhagia which is the most common abnormal bleeding pattern in perimenopausal aged women. [Int J Reprod Contracept Obstet Gynecol 2015; 4(3.000: 547-550

  16. Magnetic resonance imaging of sacroiliitis in early seronegative spondylarthropathy. Abnormalities correlated to clinical and laboratory findings

    Puhakka, K B; Jurik, A G; Schiøttz-Christensen, Berit;

    2004-01-01

    OBJECTIVE: To compare a new MRI scoring system of the sacroiliac joints (SIJs) in early spondylarthropathy (SpA) with clinical and laboratory parameters. METHODS: Forty-one patients (24 males, 17 females) with a median age of 26 yr and a median duration of inflammatory low back pain of 19 months...... were included. They all fulfilled the ESSG-criteria for SpA. The patients were examined by MRI of the SIJs using a new scoring system. Clinical examinations, biochemical tests, functional score (BASFI), and pain score (BASDAI) were also performed. RESULTS: 95% of the patients had inflammation and....../or destructive bone changes of the SIJs at MRI. No correlation was found between MRI pathology and clinical findings. MRI demonstrated significantly greater severity of both inflammation and destruction of the SIJs in HLA B27 positive patients than in the HLA B27 negative patients. CONCLUSIONS: In patients with...

  17. Follow-up of abnormal or inadequate test results in the Danish Cervical Cancer Screening Program

    Kristiansen, Bettina Kjær

    2014-01-01

    -up recommendation. However problems with delayed follow-up may threaten the effectiveness of the Danish Cervical Cancer Screening Program, as 20% of women are delayed and dysplasia potentially can progress into cancer. Delayed follow-up is found in situations where women either consciously or unconsciously postpone......Denmark has a higher incidence of cervical cancer than other Nordic countries, although all Danish women (aged 23–65) are screened regularly to identify possible cervical dysplasia or asymptomatic invasive cancer. Annually 40 000 women receives an abnormal or inadequate test result and a follow...... follow-up, or because of organizational aspects of the screening program, where communication regarding test results can fail either in content or with delay.This study will evaluate two interventions designed to increase follow-up: 1) A letter with the test result and potential recommendation for follow...

  18. [Progress in the study of syndromic hearing loss resulted from neural crest abnormalities].

    Yalan, Liu; Hua, Zhang; Yong, Feng

    2014-11-01

    More than 400 types of syndromic hearing loss (SHL) have been reported so far, in which Waardenburg syndrome (WS), congenital microtia syndrome (CMS), and large vestibular aqueduct syndrome (LVAS) are the most common ones in clinic. However, it is difficult to study the genetic basis and pathogenesis of SHL in a systematical way because of the strong clinical and genetic heterogeneity of SHL. Dysfunction of neural crest cells (NCC), which are caused by the gene interaction network extended from SOX10 and PAX3, are relevant to the phenotype of WS, CMS and LVAS. Our previous study also confirmed that the gene network was involved in the pathogenesis of WS. In this review, we summarize research progress in the pathogenic mechanisms of SHL resulted from defects in neural crest decelopment, and provide the gene interaction network of neural crest abnormalities resulting in SHL, and hope to provide research ideas and theoretical basis for the systematical study on pathogenesis of common SHL. PMID:25567871

  19. Spectral Karyotyping for identification of constitutional chromosomal abnormalities at a national reference laboratory

    Anguiano Arturo

    2012-01-01

    Full Text Available Abstract Spectral karyotyping is a diagnostic tool that allows visualization of chromosomes in different colors using the FISH technology and a spectral imaging system. To assess the value of spectral karyotyping analysis for identifying constitutional supernumerary marker chromosomes or derivative chromosomes at a national reference laboratory, we reviewed the results of 179 consecutive clinical samples (31 prenatal and 148 postnatal submitted for spectral karyotyping. Over 90% of the cases were requested to identify either small supernumerary marker chromosomes (sSMCs or chromosomal exchange material detected by G-banded chromosome analysis. We also reviewed clinical indications of those cases with marker chromosomes in which chromosomal origin was identified by spectral karyotyping. Our results showed that spectral karyotyping identified the chromosomal origin of marker chromosomes or the source of derivative chromosomal material in 158 (88% of the 179 clinical cases; the identification rate was slightly higher for postnatal (89% compared to prenatal (84% cases. Cases in which the origin could not be identified had either a small marker chromosome present at a very low level of mosaicism (

  20. PPARγ deficiency results in reduced lung elastic recoil and abnormalities in airspace distribution

    Starcher Barry C

    2010-06-01

    Full Text Available Abstract Background Peroxisome proliferator-activated receptor (PPAR-γ is a nuclear hormone receptor that regulates gene expression, cell proliferation and differentiation. We previously described airway epithelial cell PPARγ deficient mice that develop airspace enlargement with decreased tissue resistance and increased lung volumes. We sought to understand the impact of airspace enlargement in conditionally targeted mice upon the physio-mechanical properties of the lung. Methods We measured elastic recoil and its determinants, including tissue structure and surface forces. We measured alveolar number using radial alveolar counts, and airspace sizes and their distribution using computer-assisted morphometry. Results Air vs. saline-filled pressure volume profiles demonstrated loss of lung elastic recoil in targeted mice that was contributed by both tissue components and surface tension, but was proportional to lung volume. There were no significant differences in surfactant quantity/function nor in elastin and collagen content between targeted animals and littermate controls. Importantly, radial alveolar counts were significantly reduced in the targeted animals and at 8 weeks of age there were 18% fewer alveoli with 32% more alveolar ducts. Additionally, the alveolar ducts were 19% larger in the targeted animals. Conclusions Our data suggest that the functional abnormalities, including loss of recoil are secondary to altered force transmission due to differences in the structure of alveolar ducts, rather than changes in surfactant function or elastin or collagen content. These data further define the nature of abnormal lung maturation in the absence of airway epithelial cell PPARγ and identify a putative genetic determinant of dysanapsis, which may serve as a precursor to chronic lung disease.

  1. Early parathyroid hormone laboratory abnormalities related to therapeutic radiation of neck: an Egyptian experience.

    Aboelnaga, Mohamed M; Aboelnaga, Engy M

    2015-05-01

    The effect of neck radiation on parathyroid hormone (PTH) is studied on concern as late effect of radiotherapy for benign or malignant diseases. However, the early effect on PTH is still in debate and need further evaluations. We aimed, in our study, to assess early effect of neck radiation on PTH, and related calcium and phosphorus levels. Patients diagnosed with breast or head and neck cancer who planned to received radiotherapy to neck as a definite or a part of their treatment enrolled in this prospective single-arm study from June 2012 to June 2013. Laboratory assessment of PTH, serum calcium, phosphorus and albumin was obtained before starting radiotherapy, 3 weeks and 3 months after radiation. Fifty-two patients included 24 (46.2 %) males and 28(53.8 %) females. Median age of diagnosis was 55 years. Thirty-six patients had head and neck cancer, while 16 patients were diagnosed as breast cancer. The difference in PTH and calcium levels before and after radiotherapy was statistically significant (P = 0.014 and P = 0.001 for 3 weeks and P = 0.015 and P = 0.004 for 3 months, respectively); even after correction of calcium level according to albumin level, the same results were obtained, while there was no significant difference in their levels after 3 weeks in comparison with 3 months after radiotherapy. The variation of level of phosphorus was not significant. PTH and calcium can be affected early with neck radiation, so follow-up of calcium and PTH level is mandatory for cases that will receive neck radiotherapy. PMID:25904502

  2. Craniofacial abnormalities result from knock down of nonsyndromic clefting gene, crispld2, in zebrafish.

    Yuan, Qiuping; Chiquet, Brett T; Devault, Laura; Warman, Matthew L; Nakamura, Yukio; Swindell, Eric C; Hecht, Jacqueline T

    2012-12-01

    Nonsyndromic cleft lip and palate (NSCLP), a common birth defect, affects 4,000 newborns in the US each year. Previously, we described an association between CRISPLD2 and NSCLP and showed Crispld2 expression in the murine palate. These results suggested that a perturbation in CRISPLD2 activity affects craniofacial development. Here, we describe crispld2 expression and the phenotypic consequence of its loss of function in zebrafish. crispld2 was expressed at all stages of zebrafish morphogenesis examined and localized to the rostral end by 1-day postfertilization. Morpholino knockdown of crispld2 resulted in significant jaw and palatal abnormalities in a dose-dependent manner. Loss of crispld2 caused aberrant patterning of neural crest cells (NCC) suggesting that crispld2 is necessary for normal NCC formation. Altogether, we show that crispld2 plays a significant role in the development of the zebrafish craniofacies and alteration of normal protein levels disturbs palate and jaw formation. These data provide support for a role of CRISPLD2 in NSCLP. PMID:22887593

  3. Results of Laboratory Testing of Advanced Power Strips: Preprint

    Earle, L.; Sparn, B.

    2012-08-01

    This paper describes the results of a laboratory investigation to evaluate the technical performance of advanced power strip (APS) devices when subjected to a range of home entertainment center and home office usage scenarios.

  4. Endovascular treatment of symptomatic vestibular aqueduct dehiscence as a result of jugular bulb abnormalities.

    Thénint, Marie-Aude; Barbier, Charlotte; Hitier, Martin; Patron, Vincent; Saleme, Suzana; Courthéoux, Patrick

    2014-11-01

    A new endovascular treatment consisting of stent-assisted coil implantation is described for jugular bulb abnormalities causing symptomatic vestibular aqueduct dehiscence. Three patients presenting with vertigo associated with pulsatile tinnitus or hearing loss were treated. This technique cured the vertigo and pulsatile tinnitus in all patients and preserved normal cerebral venous drainage with no side effects. PMID:25442142

  5. pitx2 Deficiency results in abnormal ocular and craniofacial development in zebrafish.

    Yi Liu

    Full Text Available Human PITX2 mutations are associated with Axenfeld-Rieger syndrome, an autosomal-dominant developmental disorder that involves ocular anterior segment defects, dental hypoplasia, craniofacial dysmorphism and umbilical abnormalities. Characterization of the PITX2 pathway and identification of the mechanisms underlying the anomalies associated with PITX2 deficiency is important for better understanding of normal development and disease; studies of pitx2 function in animal models can facilitate these analyses. A knockdown of pitx2 in zebrafish was generated using a morpholino that targeted all known alternative transcripts of the pitx2 gene; morphant embryos generated with the pitx2(ex4/5 splicing-blocking oligomer produced abnormal transcripts predicted to encode truncated pitx2 proteins lacking the third (recognition helix of the DNA-binding homeodomain. The morphological phenotype of pitx2(ex4/5 morphants included small head and eyes, jaw abnormalities and pericardial edema; lethality was observed at ∼6-8-dpf. Cartilage staining revealed a reduction in size and an abnormal shape/position of the elements of the mandibular and hyoid pharyngeal arches; the ceratobranchial arches were also decreased in size. Histological and marker analyses of the misshapen eyes of the pitx2(ex4/5 morphants identified anterior segment dysgenesis and disordered hyaloid vasculature. In summary, we demonstrate that pitx2 is essential for proper eye and craniofacial development in zebrafish and, therefore, that PITX2/pitx2 function is conserved in vertebrates.

  6. Influence of diet on the results of laboratory tests

    Kinga Lis

    2013-12-01

    Full Text Available Blood and urine laboratory tests are necessary to diagnose the state of the patient. These tests are also helpful in the assessment of diet and nutritional status of the organism. It is recommended that both blood and urine for laboratory tests be collected in the morning, from fasting patients after an overnight rest. These conditions are defined as the standard conditions for collection of material for laboratory testing. Before testing, patients should follow their natural diet and avoid physical exertion, night work, long-distance travel, as well as consumption of alcohol and drugs. They should also reduce the consumption of synthetic vitamins and herbal remedies and other dietary supplements. Medications should be limited to those that are absolutely necessary. All of these factors can affect the results of laboratory tests.

  7. The 2008 M7.9 Wenchuan earthquake - Result of Local and Abnormal Mass Imbalances?

    Klose, C. D.

    2008-12-01

    The May 12, 2008 M7.9 Wenchuan earthquake occurred along the Longmen Shan margin of the eastern Tibetan plateau in the Sichuan province of the People's Republic of China. A complex and NNW dipping reverse fault system including the Beichuan fault ruptured 250-300 km parallel to the Longmen Shan thrust belt. This region has been tectonically loaded for >10kyr. It has low deformation rates of less than 1.0±1.0 mm yr-1 resulting in no major seismic activity during the Quaternary period. Several geophysical observations suggest that this M7.9 earthquake was triggered by local and abnormal mass imbalances on the surface of the Earth's crust. These observations include (1) elastostatic response of the crust to the mass changes (2) slip distribution of the main rupture, and (3) aftershock distribution. Initially, approximately 2 years prior the nucleation of the mainshock, at least 320 million tonnes of water accumulated within the upper Min river valley. It enters the Chengdu plain of the Sichuan basin, a stable continental region (SCR). The water volume amplified the strain energy on the Earth's crust. Shear stresses increased by >1kPa on the Beichuan fault at the nucleation point in about 20km depth. Normal stresses decreased by 3) along the ruptured fault zone pointed toward a very shallow seismicity in the uppermost part of crust. Data show that about 87% of the total seismic moment has been released in the upper third part of the crust (20km). Such a bimodal depth distribution with an aseismic mid crust is typical for earthquakes in stable continental regions (Klose and Seeber 2007, SRL 78:554-562). Thus, high spatiotemporal correlatives can be observed at shallow depth between both the seismic moment release of the aftershocks and the rupture slip distribution of the mainshock. This indicates that Mohr-Coulomb failure stress states were much higher in the uppermost part of crust than near a possible nucleation point of the mainshock in 19km depth. In conclusion

  8. Swine influenza test results from animal health laboratories in Canada

    Kloeze, Harold; Mukhi, Shamir N; Alexandersen, Soren

    2013-01-01

    Due to its infrastructure and partnerships the Canadian Animal Health Surveillance Network was able to rapidly collect test results from 9 Canadian laboratories that were conducting primary testing for influenza on swine-origin samples, in response to the threat posed by the pandemic H1N1 influenza virus in 2009.

  9. Transcriptional activation by TAL1 and FUS-CHOP proteins expressed in acute malignancies as a result of chromosomal abnormalities.

    Sánchez-García, I; Rabbitts, T H

    1994-01-01

    Proteins that appear to participate in transcriptional control of gene expression are increasingly implicated in leukemias and malignant solid tumors. We report here that the N-terminal domains of the proteins TAL1 (ectopically activated in T-cell acute leukemias after chromosomal abnormalities caused by V-D-J recombinase error) (V, variable; D, diversity; J, joining) and FUS-CHOP (a liposarcoma tumor-specific fusion protein that is produced as a result of a chromosomal translocation) can fun...

  10. Loss of the BRCA1-interacting helicase BRIP1 results in abnormal mammary acinar morphogenesis.

    Kazuhiro Daino

    Full Text Available BRIP1 is a DNA helicase that directly interacts with the C-terminal BRCT repeat of the breast cancer susceptibility protein BRCA1 and plays an important role in BRCA1-dependent DNA repair and DNA damage-induced checkpoint control. Recent studies implicate BRIP1 as a moderate/low-penetrance breast cancer susceptibility gene. However, the phenotypic effects of BRIP1 dysfunction and its role in breast cancer tumorigenesis remain unclear. To explore the function of BRIP1 in acinar morphogenesis of mammary epithelial cells, we generated BRIP1-knockdown MCF-10A cells by short hairpin RNA (shRNA-mediated RNA interference and examined its effect in a three-dimensional culture model. Genome-wide gene expression profiling by microarray and quantitative RT-PCR were performed to identify alterations in gene expression in BRIP1-knockdown cells compared with control cells. The microarray data were further investigated using the pathway analysis and Gene Set Enrichment Analysis (GSEA for pathway identification. BRIP1 knockdown in non-malignant MCF-10A mammary epithelial cells by RNA interference induced neoplastic-like changes such as abnormal cell adhesion, increased cell proliferation, large and irregular-shaped acini, invasive growth, and defective lumen formation. Differentially expressed genes, including MCAM, COL8A1, WIPF1, RICH2, PCSK5, GAS1, SATB1, and ELF3, in BRIP1-knockdown cells compared with control cells were categorized into several functional groups, such as cell adhesion, polarity, growth, signal transduction, and developmental process. Signaling-pathway analyses showed dysregulation of multiple cellular signaling pathways, involving LPA receptor, Myc, Wnt, PI3K, PTEN as well as DNA damage response, in BRIP1-knockdown cells. Loss of BRIP1 thus disrupts normal mammary morphogenesis and causes neoplastic-like changes, possibly via dysregulating multiple cellular signaling pathways functioning in the normal development of mammary glands.

  11. COMPILATION OF LABORATORY SCALE ALUMINUM WASH AND LEACH REPORT RESULTS

    HARRINGTON SJ

    2011-01-06

    This report compiles and analyzes all known wash and caustic leach laboratory studies. As further data is produced, this report will be updated. Included are aluminum mineralogical analysis results as well as a summation of the wash and leach procedures and results. Of the 177 underground storage tanks at Hanford, information was only available for five individual double-shell tanks, forty-one individual single-shell tanks (e.g. thirty-nine 100 series and two 200 series tanks), and twelve grouped tank wastes. Seven of the individual single-shell tank studies provided data for the percent of aluminum removal as a function of time for various caustic concentrations and leaching temperatures. It was determined that in most cases increased leaching temperature, caustic concentration, and leaching time leads to increased dissolution of leachable aluminum solids.

  12. COMPILATION OF LABORATORY SCALE ALUMINUM WASH AND LEACH REPORT RESULTS

    This report compiles and analyzes all known wash and caustic leach laboratory studies. As further data is produced, this report will be updated. Included are aluminum mineralogical analysis results as well as a summation of the wash and leach procedures and results. Of the 177 underground storage tanks at Hanford, information was only available for five individual double-shell tanks, forty-one individual single-shell tanks (e.g. thirty-nine 100 series and two 200 series tanks), and twelve grouped tank wastes. Seven of the individual single-shell tank studies provided data for the percent of aluminum removal as a function of time for various caustic concentrations and leaching temperatures. It was determined that in most cases increased leaching temperature, caustic concentration, and leaching time leads to increased dissolution of leachable aluminum solids.

  13. Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation.

    Temin, H M

    1993-01-01

    Human immunodeficiency virus variation is extensive and is based on numerous mistakes in reverse transcription. All retrovirus replication requires two strand transfers (growing point jumps) to synthesize the complete provirus. I propose that the numerous mistakes in reverse transcription are the result of this requirement for the two strand transfers needed to form the provirus.

  14. Factors Associated with Parental Perception of Child Vulnerability 12 months After Abnormal Newborn Screening Results

    Tluczek, Audrey; McKechnie, Anne Chevalier; Brown, Roger L

    2011-01-01

    We identified factors associated with elevated parental perceptions of child vulnerability (PPCV) 12 months after newborn screening (NBS) of 136 children: healthy, normal results (H, n=37), cystic fibrosis carriers (CF-C, n=40), congenital hypothyroidism (CH, n=36), and cystic fibrosis (CF, n=23). Controlling for infant and parent characteristics, mixed logit structural equation modeling showed direct paths to PPCV included parent female sex, CF diagnosis, and high documented illness frequenc...

  15. AVD: A new system for computer-aided analysis of wall movement abnormalities; first results

    A man-machine comparison proves the reliability of the new computer-based system. The results with and without the ADV-system agree to a high degree. The computer-aided analysis with two different models yields qualitatively and quantitatively similar results. With the computer-aided system one can save 90% of the time, compared to the manual technique; this is an essential prerequisite for the wide application of quantitative analysis of wall movements. The possibility for a quantitative analysis of wall movements is the basis for inter- and intraindividual comparisons after interventions, i.e. exercise tests, applications of pharmaceuticals or after by-pass surgery. The flexibility of the system allows checks of the result by a repetition of the analysis with a different model. This way the reliability of the findings is improved. The ADV-system in its present shape needs some changes in its program, improved handling and a faster graphic terminal. Common plotters are better than the currently used modified printer. Also, the program should be extended in its new version for batch-processing, i.e. independent of the operator it should process serial analysis of patient collectives. These suggestions have been accepted by the manufacturer in the meantime, and modifications will be made. (orig.)

  16. Aid in the detection of myocardial perfusion abnormality utilizing SPECT atlas and images registration: preliminary results

    Padua, Rodrigo Donizete Santana de [Universidade de Sao Paulo (USP), Ribeirao Preto, SP (Brazil). Faculdade de Medicina. Div. de Cardiologia]. E-mail: rodrigo_dsp@hcrp.fmrp.usp.br; Oliveira, Lucas Ferrari de [Universidade Federal de Pelotas (UFPel), RS (Brazil). Inst. de Fisica e Matematica. Dept. de Tecnologia da Informacao; Marques, Paulo Mazzoncini de Azevedo [Universidade de Sao Paulo (USP), Ribeirao Preto, SP (Brazil). Faculdade de Medicina. Centro de Ciencias das Imagens e Fisica Medica; Groote, Jean-Jacques Georges Soares de [Instituto de Ensino Superior COC, Ribeirao Preto, SP (Brazil). Lab. of Artifical Intelligence and Applications; Castro, Adelson Antonio de [Universidade de Sao Paulo (USP), Ribeirao Preto, SP, (Brazil). Faculdade de Medicina; Ana, Lauro Wichert [Universidade de Sao Paulo (USP), Ribeirao Preto, SP (Brazil). Faculdade de Medicina. Centro de Ciencias das Imagens e Fisica Medica; Simoes, Marcus Vinicius [Universidade de Sao Paulo (USP), Ribeirao Preto, SP, (Brazil). Faculdade de Medicina. Divisao de Cardiologia

    2008-11-15

    To develop an atlas of myocardial perfusion scintigraphy and evaluating its applicability in computer-aided detection of myocardial perfusion defects in patients with ischemic heart disease. The atlas was created with rest-stress myocardial perfusion scintigraphic images of 20 patients of both genders with low probability of coronary artery disease and considered as normal by two experienced observers. Techniques of image registration and mathematical operations on images were utilized for obtaining template images depicting mean myocardial uptake and standard deviation for each gender and physiological condition. Myocardial perfusion scintigraphy images of one male and one female patient were aligned with the corresponding atlas template image, and voxels with myocardial uptake rates two standard deviations below the mean voxel value of the respective region in the atlas template image were highlighted on the tomographic sections and confirmed as perfusion defects by both observe. The present study demonstrated the creation of an atlas of myocardial perfusion scintigraphy with promising results of this tool as an aid in the detection of myocardial perfusion defects. However, further prospective validation with a more representative sample is recommended. (author)

  17. Aid in the detection of myocardial perfusion abnormality utilizing SPECT atlas and images registration: preliminary results

    To develop an atlas of myocardial perfusion scintigraphy and evaluating its applicability in computer-aided detection of myocardial perfusion defects in patients with ischemic heart disease. The atlas was created with rest-stress myocardial perfusion scintigraphic images of 20 patients of both genders with low probability of coronary artery disease and considered as normal by two experienced observers. Techniques of image registration and mathematical operations on images were utilized for obtaining template images depicting mean myocardial uptake and standard deviation for each gender and physiological condition. Myocardial perfusion scintigraphy images of one male and one female patient were aligned with the corresponding atlas template image, and voxels with myocardial uptake rates two standard deviations below the mean voxel value of the respective region in the atlas template image were highlighted on the tomographic sections and confirmed as perfusion defects by both observe. The present study demonstrated the creation of an atlas of myocardial perfusion scintigraphy with promising results of this tool as an aid in the detection of myocardial perfusion defects. However, further prospective validation with a more representative sample is recommended. (author)

  18. Cement/bentonite interaction. Results from 16 month laboratory tests

    The work concerns possible bentonite clay mineral alteration in constructions with bentonite in close contact with cement, and the effect of such changes on bentonite buffer properties. The investigation comprises a 16 months laboratory test series with hydrothermal cell tests, percolation tests and diffusion tests. MX-80 Wyoming bentonite was used in all tests. Two types of artificial cement pore water solutions were used in the percolation and diffusion tests. The swelling pressure and the hydraulic conductivity were measured continuously in the percolation tests. After termination, the clay was analyzed with respect to changes in element distribution, mineralogy and shear strength. The water solutions were analyzed with respect to pH, cations and major anions. The results concerning chemical and mineralogical changes are in summary: Ion exchange in the montmorillonite until equilibrium with cement pore-water ions was reached; Increase in cation exchange capacity; Dissolution of original cristobalite; Increase in quartz content; Minor increase in illite content; Minor formation of chlorite; Formation of CSH(I); Wash away of CSH-gel into surrounding water. A large decrease in swelling pressure and a moderate increase in hydraulic conductivity were recorded in the samples percolated by SULFACEM pore-water solution. The mineralogical alterations only concerned a minor part of the total bentonite mass and the changes in physical properties were therefore most likely due to the replacement of the original charge balancing cation by cement pore-water cations. Comparisons between the current test result and results from 4 month tests indicate that the rates of illite and chlorite formation were reduced during the tests. The presence of zeolites in the clay could not be ensured. However, the discovery of CSH material is important since CSH is expected to precede the formation of zeolites

  19. CIAXE: co-axial achromatic interferential coronagraph: first laboratory results

    Allouche, Fatmé; Gay, Jean; Rabbia, Yves; Assus, Pierre

    2010-07-01

    In 1996, Jean Gay and Yves Rabbia presented their Achromatic Interferential Coronagraph (AIC) for detecting and imaging faint companions (ultimately exoplanets) in the neighboring of a star. As presented then, the Michleson-like Interferometer configuration of the AIC hardens its insertion into an existing (coaxial) optical train, the output beam of the AIC being delivered at right angle from the input beam. To overcome this, they reconfigured the AIC into a compact and fully axial coronagraph, the CIAXE, which main feature consists of using two thick lenses machined in the same optical material. For the CIAXE to deliver the output beam along the same axis as the input beam, the two lenses are coaxially disposed on the optical axis and are separated, at their common spherical contact surface by a thin air gap acting like a beam splitter. We have set up a laboratory experiment aiming at validating the principle of the concept. Our first step was to equalize the thicknesses of the two lenses, so as to make zero the optical path difference between both arms. For this, the (residual) value of the OPD has been evaluated and then the lenses have been re-machined so as to decrease as far as technologically possible, the thicknesses mismatch. As a second step, a micro-controlled rotation around the common curvature center of the spherical surfaces of the lenses is applied. This allows a fine tuning of the residual OPD at the required accuracy level. Are presented here test bench, steps and results.

  20. Meta-Analysis Combines Affymetrix Microarray Results Across Laboratories

    Doerge, R. W.; John R. Stevens

    2005-01-01

    With microarray technology becoming more prevalent in recent years, it is now common for several laboratories to employ the same microarray technology to identify differentially expressed genes that are related to the same phenomenon in the same species. Although experimental specifics may be similar, each laboratory will typically produce a slightly different list of statistically significant genes, which calls into question the validity of each gene list (i.e. which list is best). A statist...

  1. Prevalence and prognostic significance of ECG abnormalities in HIV-infected patients: results from the Strategies for Management of Antiretroviral Therapy study

    Soliman, Elsayed Z; Prineas, Ronald J; Roediger, Mollie P;

    2011-01-01

    BACKGROUND: It remains debated whether to include resting electrocardiogram (ECG) in the routine care of human immunodeficiency virus (HIV)-infected patients. METHODS: This analysis included 4518 HIV-infected patients (28% women and 29% blacks) from the Strategies for Management of Antiretroviral...... Therapy study, a clinical trial aimed to compare 2 HIV treatment strategies. ECG abnormalities were classified using the Minnesota Code. Cox proportional hazards analysis was used to examine the association between baseline ECG abnormalities and incident cardiovascular disease (CVD). RESULTS: More than...... half of the participants (n = 2325, or 51.5%) had either minor or major ECG abnormalities. Minor ECG abnormalities (48.6%) were more common than major ECG abnormalities (7.7%). During a median follow-up of 28.7 months, 155 participants (3.4%) developed incident CVD. After adjusting for the study...

  2. Heterogeneity of laboratory test results for antiphospholipid antibodies in patients treated with chlorpromazine and other phenothiazines.

    Lillicrap, D P; Pinto, M; Benford, K; Ford, P M; Ford, S

    1990-06-01

    Ninety-seven psychiatric patients who have been treated with the antipsychotic drug chlorpromazine or another phenothiazine have been investigated for the presence of antiphospholipid antibodies. A variety of coagulation studies and specific antiphospholipid immunoassays were performed to define the spectrum of antigen specificity of these antibodies. Coagulation studies showed an increasing sensitivity for the lupus anticoagulant with reagents of differing phospholipid content. Prolonged activated partial thromboplastin times (APTTs) were found in five patients with the use of an insensitive APTT reagent and in 14 patients with a lower phospholipid content reagent. In every case, attempted correction of the clotting time with normal plasma was unsuccessful. Twenty-one patients had abnormal kaolin clotting time profiles. In seven of these patients, test results with both APTT reagents had been normal. Antibody reactivity was tested against three negatively charged phospholipids, phosphatidyl-serine, cardiolipin, and phosphatidylinositol. Only five patients demonstrated reactivity against phosphatidylinositol, whereas high antibody titers were observed in 28 patients against one or both of phosphatidylserine and cardiolipin. Twenty-three of these patients were found to have elevated anticardiolipin-specific IgM antibodies. Overall, 41 of the patients had at least one laboratory abnormality suggestive of antiphospholipid antibody activity. Seven of the 26 patients, taking phenothiazines other than chlorpromazine, had positive test results for antiphospholipid antibodies. No clinical thromboembolic events were recorded in any patient. These findings demonstrate the heterogeneity of antiphospholipid antibody specificity induced in patients treated with various phenothiazine drugs and indicate that none of these patterns of reactivity marks a predisposition for thromboembolism in this population. PMID:1971739

  3. EM techniques for archaeological laboratory experiments: preliminary results

    Capozzoli, Luigi; De Martino, Gregory; Giampaolo, Valeria; Raffaele, Luongo; Perciante, Felice; Rizzo, Enzo

    2015-04-01

    The electromagnetic techniques (EM) are based on the investigation of subsoil geophysical parameters and in the archaeological framework they involve in studying contrasts between the buried cultural structures and the surrounding materials. Unfortunately, the geophysical contrast between archaeological features and surrounding soils sometimes are difficult to define due to problems of sensitivity and resolution both related on the characteristic of the subsoil and the geophysical methods. For this reason an experimental activity has been performed in the Hydrogeosite laboratory addressed on the assessment of the capability of geophysical techniques to detect archeological remains placed in the humid/saturated subsoil. At Hydrogeosite Laboratory of CNR-IMAA, a large scale sand-box is located, consisting on a pool shape structures of 230m3 where archaeological remains have been installed . The remains are relative to a living environment and burial of Roman times (walls, tombs, roads, harbour, etc.) covered by sediments. In order to simulate lacustrine and wetland condition and to simulate extreme events (for example underwater landslide, fast natural erosion coast, etc.) the phreatic level was varied and various acquisitions for the different scenarios were performed. In order to analyze the EM behavior of the buried small archaeological framework, ground penetrating radar (GPR) and electrical resistivity tomographies were performed. With GPR, analysis in time domain and frequency domain were performed and coupled to information obtained through resistivity analysis with the support of numerical simulations used to compare the real data with those modeled. A dense grid was adopted for 400 and 900 MHz e-m acquisitions in both the directions, the maximum depth of investigation was limited and less than 3 meters. The same approach was used for ERT acquisition where different array are employed, in particular 3D configuration was used to carry out a 3D resistivity

  4. Results of Laboratory Testing of Advanced Power Strips

    Earle, L. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sparn, B. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2012-08-01

    Presented at the ACEEE Summer Study on Energy Efficiency in Buildings on August 12-17, 2012, this presentation reports on laboratory tests of 20 currently available advanced power strip products, which reduce wasteful electricity use of miscellaneous electric loads in buildings.

  5. Measurement of floor convectors at special laboratory and first results

    Müller Miloš; Peukert Pavel

    2012-01-01

    This article describes the laboratory for measurement of floor convectors in cooling and heating regime. The experimental setup used for the measurement is described. The heating and cooling power are calculated based on the mass flow and temperature measurement. Particle trace method is used for the visualization of the flow inside and outside the convector. A testing measurement is performed to evaluate the influence of the convector covering on the output power.

  6. Mars Science Laboratory relative humidity observations: Initial results

    Harri, A-M; Genzer, M; O. Kemppinen; Gomez-Elvira, J.; Haberle, R.; Polkko, J.; H. Savijärvi; Rennó, N.; Rodriguez-Manfredi, JA; Schmidt, W.; Richardson, M; Siili, T; Paton, M; Torre-Juarez, M De La; T. Mäkinen

    2014-01-01

    The Mars Science Laboratory (MSL) made a successful landing at Gale crater early August 2012. MSL has an environmental instrument package called the Rover Environmental Monitoring Station (REMS) as a part of its scientific payload. REMS comprises instrumentation for the observation of atmospheric pressure, temperature of the air, ground temperature, wind speed and direction, relative humidity (REMS-H), and UV measurements. We concentrate on describing the REMS-H measurement performance and in...

  7. RNA interference of Marlin-1/Jakmip1 results in abnormal morphogenesis and migration of cortical pyramidal neurons.

    Vidal, René L; Fuentes, Patricio; Valenzuela, José Ignacio; Alvarado-Diaz, Carlos P; Ramírez, Omar A; Kukuljan, Manuel; Couve, Andrés

    2012-08-01

    The formation of the nervous systems requires processes that coordinate proliferation, differentiation and migration of neuronal cells, which extend axons, generate dendritic branching and establish synaptic connections during development. The structural organization and dynamic remodeling of the cytoskeleton and its association to the secretory pathway are critical determinants of cell morphogenesis and migration. Marlin-1 (Jakmip1) is a microtubule-associated protein predominantly expressed in neurons and lymphoid cells. Marlin-1 participates in polarized secretion in lymphocytes, but its functional association with the neuronal cytoskeleton and its contribution to brain development have not been explored. Combining in vitro and in vivo approaches we show that Marlin-1 contributes to the establishment of neuronal morphology. Marlin-1 associates to the cytoskeleton in neurites, is required for the maintenance of an intact Golgi apparatus and its depletion produces the down-regulation of kinesin-1, a plus-end directed molecular motor with a central function in morphogenesis and migration. RNA interference of Marlin-1 in vivo results in abnormal migration of newborn pyramidal neurons during the formation of the cortex. Our results support the involvement of Marlin-1 in the acquisition of the complex architecture and migration of pyramidal neurons, two fundamental processes for the laminar layering of the cortex. PMID:22828129

  8. [Syringomyelia and Chiari abnormality in the adult. Analysis of the results of a cooperative series of 285 cases].

    Aghakhani, N; Parker, F; Tadié, M

    1999-06-01

    This chapter discusses the retrospective data found in 285 patients with syringomyelia associated with Chiari abnormality and collected from 18 neurosurgical departments. A pre and postoperative MRI study and a minimum follow up of at least 2 years were required. A scale of severity was fixed and tested before and after treatment. The size of the cyst, the degree of the foraminal obstruction were analyzed. The mean age at diagnosis was about 39 years and the duration of symptoms about 6.7 years. Sensory disorders were present in 91% of cases, pain in 66% and motor deficit in about 60%. According to our functional classification, the majority of our patients were moderately disabled and only 10.8% showed a severe impotence. Results of the two major surgical procedures, foramen magnum decompression (FMD) (88% of cases) and cyst shunting procedures (SP) (32% of cases) were evaluated with a mean follow-up period of 6.7 years (ranged from 2 to 14 years). Better clinical and morphological results (87% of stabilization or improvement for FMD versus 71% for SP) were obtained by FMD procedure comparing to SP, with the same rate of complications. PMID:10420402

  9. Psychosocial impact of alternative management policies for low-grade cervical abnormalities: results from the TOMBOLA randomised controlled trial.

    Linda Sharp

    Full Text Available BACKGROUND: Large numbers of women who participate in cervical screening require follow-up for minor cytological abnormalities. Little is known about the psychological consequences of alternative management policies for these women. We compared, over 30-months, psychosocial outcomes of two policies: cytological surveillance (repeat cervical cytology tests in primary care and a hospital-based colposcopy examination. METHODS: Women attending for a routine cytology test within the UK NHS Cervical Screening Programmes were eligible to participate. 3399 women, aged 20-59 years, with low-grade abnormal cytology, were randomised to cytological surveillance (six-monthly tests; n = 1703 or initial colposcopy with biopsies and/or subsequent treatment based on colposcopic and histological findings (n = 1696. At 12, 18, 24 and 30-months post-recruitment, women completed the Hospital Anxiety and Depression Scale (HADS. A subgroup (n = 2354 completed the Impact of Event Scale (IES six weeks after the colposcopy episode or first surveillance cytology test. Primary outcomes were percentages over the entire follow-up period of significant depression (≥ 8 and significant anxiety (≥ 11; "30-month percentages". Secondary outcomes were point prevalences of significant depression, significant anxiety and procedure-related distress (≥ 9. Outcomes were compared between arms by calculating fully-adjusted odds ratios (ORs for initial colposcopy versus cytological surveillance. RESULTS: There was no significant difference in 30-month percentages of significant depression (OR = 0.99, 95% CI 0.80-1.21 or anxiety (OR = 0.97, 95% CI 0.81-1.16 between arms. At the six-week assessment, anxiety and distress, but not depression, were significantly less common in the initial colposcopy arm (anxiety: 7.9% vs 13.4%; OR = 0.55, 95% CI 0.38-0.81; distress: 30.6% vs 39.3%, OR = 0.67 95% CI 0.54-0.84. Neither anxiety nor depression differed between arms at subsequent time

  10. Influence of extracardiac activity and perfusion abnormalities on the results of myocardial gated SPECT with commercial software

    cardiology, rated accordingly 1 through 4, where No.1 was the most experienced). They used the available software tools to mask and relocate the cardiac area when necessary. For the analysis, commercial software QGS and QPS (Cedars) was used. The software provides automatic functional and perfusion parameters. We analysed left diastolic and systolic ventricular volumes (EDV and ESV), left ventricular ejection fraction (LVEF) and reversibility perfusion score (SDS) as well as perfusion defect extension, at rest. Resulting data were compared using correlation Pearson test and student t test. Results A. Whole group. Automatic LVEF, volumes and perfusion parameters of ischemia and rest perfusion defects are shown. Regarding functional parameters, the mean values between processings were not statistically different for volumes and for LVEF, excluding operator 2 with 4 and automatic with operator 4 (p<0.01). The correlations between operators and automatic software for LVEF ranged between: 0.90-9.96, interoperator ranged between 0.90-0.96; for Volumes: 0.86-0.99 and 0.87-0.98; for SDS: 0.81-0.87 and 0.81-0.94; for Extension at rest: 0.74-0.88 and 0.74-0.99, respectively. B. Comparative analysis in groups with and without extracardiac activity. The interoperator correlations were worse in patients with extracardiac activity compared with those without it, with a wider range of values: Average LVEF r: 0.93 vs 0.94 [range: 0.89-0.96 vs 0.90-0.95]; Average Volumes r: 0.91 vs 0.93 [range: 0.83-0.98 vs 0.91-0.98]; Average SDS r: 0.89 vs 0.92 [range: 0.85-0.92 vs 0.88-0.96]; Average Rest Extent r: 0.86 vs 0.99 [range: 0.73-0.98 vs 0.99-0.995] C. Comparative analysis in groups with and without myocardial perfusion abnormalities. The interoperator correlations were not affected by the presence of perfusion defects versus those patients with normal radiotracer uptake, but a wider range was observed among the latter: Average LVEF r: 0.95 vs 0.89 [range: 0.93-0.98 vs 0.82-0.95]; Average

  11. Idaho National Laboratory Vadose Zone Research Park Geohydrological Monitoring Results

    Kristine Baker

    2006-01-01

    Vadose zone lithology, hydrological characterization of interbed sediments, and hydrological data from subsurface monitoring of Idaho Nuclear Technology and Engineering Center wastewater infiltration are presented. Three-dimensional subsurface lithology of the vadose zone beneath the Vadose Zone Research Park is represented in a 2 dimensional (2 D) diagram showing interpolated lithology between monitoring wells. Laboratory-measured values for saturated hydraulic conductivity and porosity are given for three major interbeds, denoted as the B BC interbed (20 to 35 m bls), the C D interbed (40 to 45 m bls), and the DE 1 2 interbed (55 to 65 m bls), along with an overall physical description of the sediments and geologic depositional environments. Pre-operational pore water pressure conditions are presented to show the presence and location of perched water zones before pond discharge at the New Percolation Ponds. Subsurface infiltration conditions during initial high-volume discharge are presented to show water arrival times and arrival sequences. Steady-state conditions are then presented to show formation and locations of perched water zones and recharge sources after several months of discharge to the New Percolation Ponds.

  12. 48 CFR 1511.011-80 - Data standards for the transmission of laboratory measurement results.

    2010-10-01

    ... transmission of laboratory measurement results. 1511.011-80 Section 1511.011-80 Federal Acquisition Regulations... standards for the transmission of laboratory measurement results. The contracting officer shall insert the... transmission of environmental measurements from laboratories to the Environmental Protection Agency (EPA)....

  13. 48 CFR 1552.211-80 - Data standards for the transmission of laboratory measurement results.

    2010-10-01

    ... transmission of laboratory measurement results. 1552.211-80 Section 1552.211-80 Federal Acquisition Regulations... Texts of Provisions and Clauses 1552.211-80 Data standards for the transmission of laboratory... Transmission of Laboratory Measurement Results (OCT 2000) This contract requires the transmission...

  14. Laboratory-scale analysis of aquifer remediation by in-well vapor stripping 1. Laboratory results

    Gonen, Ori; Gvirtzman, Haim

    1997-12-01

    This study is a laboratory test of the aquifer remediation concept proposed by Gvirtzman and Gorelick (1992, Transp. Porous Media, 8: 71-92), which involves the removal of volatile organic compounds (VOCs) dissolved in groundwater. The principle is to inject air into a well, creating air-lift pumping, which is used as a means of in-well vapor stripping. The partially treated water is separated from the VOC vapor and infiltrates back to the water table. A laboratory-scale aquifer model containing a remediation-well prototype was used to trace VOC removal over time. The removal rates of trichloroethylene (TCE), toluene and chloroform were monitored using eight triple-level observation wells. The continuous decrease of VOC concentrations in space and time was interpreted based on three processes: (1) the diffusional mass transfer between the contaminated water and the air bubbles during their rise within the well: (2) the desorption of VOCs from the solid matrix to the water phase; (3) the flow field in the saturated zone driven by the continuous water circulation between the pumping well and the recharging area. In a companion paper (Pinto et al., 1997), three-dimensional flow and transport modeling with inter-phase mass transfer is carried out to simulate these processes.

  15. Correlations Between in situ DCP Test and Laboratory Test Results

    Plătică, Elena-Irina; Pohrib, Dana-Mădălina

    2014-01-01

    Geotechnical engineers are interested in investigating the actual behavior of the soil. Currently there are several methods available for assessing the properties of the soil. The variability of the geotechnical parameters resulting from these methods is neglected assuming that the mass of the soil is homogeneous and the variation of these parameters at various is rareli considered. Heterogeneity is a characteristic of the soil because their parameters vary from one point to another. To get a...

  16. Genetic variation on 9p22 is associated with abnormal ovarian ultrasound results in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

    Nicolas Wentzensen

    Full Text Available BACKGROUND: A recent ovarian cancer genome-wide association study (GWAS identified a locus on 9p22 associated with reduced ovarian cancer risk. The single nucleotide polymorphism (SNP markers localize to the BNC2 gene, which has been associated with ovarian development. METHODS: We analyzed the association of 9p22 SNPs with transvaginal ultrasound (TVU screening results and CA-125 blood levels from participants without ovarian cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO; 1,106 women with adequate ultrasound screening results and available genotyping information were included in the study. RESULTS: We observed a significantly increased risk of abnormal suspicious TVU results for seven SNPs on 9p22, with odds ratios between 1.68 (95% CI: 1.04-2.72 for rs4961501 and 2.10 (95% CI: 1.31-3.38 for rs12379183. Associations were restricted to abnormal suspicious findings at the first TVU screen. We did not observe an association between 9p22 SNPs and CA-125 levels. CONCLUSIONS: Our findings suggest that 9p22 SNPs, which were found to be associated with decreased risk of ovarian cancer in a recent GWAS, are associated with sonographically detectable ovarian abnormalities. Our results corroborate the relevance of the 9p22 locus for ovarian biology. Further studies are required to understand the complex relationship between screening abnormalities and ovarian carcinogenesis and to evaluate whether this locus can influence the risk stratification of ovarian cancer screening.

  17. Laboratory study of corrosion of steam generator tubes: Preliminary results

    The secondary side intergranular attack (IGA) and intergranular stress corrosion cracking (IGSCC) of steam generator tubes often occurs in crevices where impurities are concentrated, due to local elevated temperatures and restricted water flow. From the analysis of tubes pulled from plants, it is believed that alumino-silicates deposits and/or organic species may play a role in the development of IGA in near neutral environments. New observations suggest that similar environments and similar processes are operative inside the corroded grain boundaries. A former study using autoclave tests was mainly devoted to the formation of alumino-silicate deposits similar to those observed in plants. The present work pursued the study of local environments responsible for IGA/SC. It confirms former results on the catalytic decomposition of organic species into acetates and presents more details on the mechanism of formation of alumino-silicate deposits on alloy 600, particularly on the role of iron and, to a lesser extent, nickel cations. It was showed that, under the alumino-silicate deposits and in the presence of some organic species, a non-protective chromium rich layer may grow instead of the usual protective spinel oxide. The mechanism responsible for the formation of this layer is believed to involve interaction between iron and, to a lesser extent, nickel with silica and/or possible interaction between chromium and acetates. Preliminary capsule tests indicate that these conditions may induce the initiation of IGA

  18. Mutation of the fucose-specific β1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine

    Sally L Dunwoodie

    2009-01-01

    Mutation of the fucose-specific ?1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine correspondence: Tel: 612 9295 8613; fax: 612 9295 8668. (Dunwoodie, Sally L.) (Dunwoodie, Sally L.) Developmental Biology Division, Victor Chang Cardiac Research Institute, 405 Liverpool Street Darlinghurst. University of New South Wales 2010 - Sydney--> - AUSTRALIA (Dunwoodie, Sally L.) ...

  19. Temporomandibular joint (TMJ) arthrography: results of a five year prospective study and various examples of TMJ abnormalities

    TMJ pain dysfunction is an important and common clinical problem. TMJ arthrography is most helpful in diagnosing internal derangements of the joint. The best technique of examination includes: a) both joint spaces opacification; b) spot films in the sagittal and coronal planes; and c) a videofluoroscopic taping. The distribution of the TMJ abnormalities detected in 585 TMJ arthrograms is reported. Women are much more affected than men (ratio: 4/1). The most frequent entity is meniscus displacement (65.4%). Complications are not frequent and mild (slight post arthrographic pain or transitory facial paresia). (author)

  20. Risk assessment models in genetics clinic for array comparative genomic hybridization: Clinical information can be used to predict the likelihood of an abnormal result in patients

    Marano, Rachel M.; Mercurio, Laura; Kanter, Rebecca; Doyle, Richard; Abuelo, Dianne; Morrow, Eric M.; Shur, Natasha

    2013-01-01

    Array comparative genomic hybridization (aCGH) testing can diagnose chromosomal microdeletions and duplications too small to be detected by conventional cytogenetic techniques. We need to consider which patients are more likely to receive a diagnosis from aCGH testing versus patients that have lower likelihood and may benefit from broader genome wide scanning. We retrospectively reviewed charts of a population of 200 patients, 117 boys and 83 girls, who underwent aCGH testing in Genetics Clinic at Rhode Island hospital between 1 January/2008 and 31 December 2010. Data collected included sex, age at initial clinical presentation, aCGH result, history of seizures, autism, dysmorphic features, global developmental delay/intellectual disability, hypotonia and failure to thrive. aCGH analysis revealed abnormal results in 34 (17%) and variants of unknown significance in 24 (12%). Patients with three or more clinical diagnoses had a 25.0% incidence of abnormal aCGH findings, while patients with two or fewer clinical diagnoses had a 12.5% incidence of abnormal aCGH findings. Currently, we provide families with a range of 10–30% of a diagnosis with aCGH testing. With increased clinical complexity, patients have an increased probability of having an abnormal aCGH result. With this, we can provide individualized risk estimates for each patient.

  1. Report of the research results with University of Tokyo, Nuclear Engineering Research Laboratory's Facilities in fiscal 1982

    The results of the research carried out in fiscal 1982 commonly using the facilities in the Nuclear Engineering Research Laboratory, University of Tokyo, are summarized in this report. In the utilization of the nuclear reactor, the maximum output was limited to 500W, because it was necessary to examine the growth of the abnormal protrusion having arisen on fuel cladding. The linear accelerator was utilized almost perfectly. The total number of those who commonly utilized the facilities was 2,468, suggesting the importance of the role of common utilization. The summaries of the results of 12 on-pile researches, 11 off-pile researches and 18 researches using the linear accelerator are collected. The committee meetings held in fiscal 1982 are listed. The names of the members of various committees and the names of those in charge of various experiments are given. (Kako, I.)

  2. Use of laboratory test results in patient management by clinicians in Malawi

    Kundai Moyo

    2015-05-01

    Full Text Available Background: Malawi has a high burden of infectious disease. The expansion of programmes targeting these diseases requires a strong laboratory infrastructure to support both diagnosis and treatment.Objectives: To assess the use of laboratory test results in patient management and to determine the requirements for improving laboratory services.Methods: A cross-sectional study was conducted in 2012 to survey practising clinicians.Two hospitals were purposively selected for observations of clinicians ordering laboratory tests. Twelve management-level key informants were interviewed. Descriptive statistics were conducted.Results: A total of 242 clinicians were identified and 216 (89% were interviewed. Of these, 189 (87% reported doubting laboratory test results at some point. Clinicians most often doubted the quality of haematology (67%, followed by malaria (53% and CD4 (22% test results. A total of 151 (70% clinicians reported using laboratory tests results in patient management. Use of laboratory test results at all times in patient management varied by the type of health facility (P < 0.001. Ninety-one percent of clinicians reported that laboratories required infrastructure improvement. During 97 observations of clinicians’ use of laboratory test results, 80 tests were ordered, and 73 (91% of these were used in patient management. Key informants reported that the quality of laboratory services was good and useful, but that services were often unavailable.Conclusion: Gaps in the public laboratory system were evident. Key recommendations to enhance the use of laboratory test results in patient management were to strengthen the supply chain, reduce turn-around times, improve the test menu and improve the laboratory infrastructure.

  3. Preoperative Laboratory Testing.

    Bock, Matthias; Fritsch, Gerhard; Hepner, David L

    2016-03-01

    Routine preoperative testing is not cost-effective, because it is unlikely to identify significant abnormalities. Abnormal findings from routine testing are more likely to be false positive, are costly to pursue, introduce a new risk, increase the patient's anxiety, and are inconvenient to the patient. Abnormal findings rarely alter the surgical or anesthetic plan, and there is usually no association between perioperative complications and abnormal laboratory results. Incidental findings and false positive results may lead to increased hospital visits and admissions. Preoperative testing needs to be done based on a targeted history and physical examination and the type of surgery. PMID:26927738

  4. Results of the Interlaboratory Exercise CNS/CIEMAT-2008 among Environmental Radioactivity Laboratories (Phosphogypsum)

    The document describes the outcome of the CSN/CIEMAT-2008 interlaboratory test comparison among environmental radioactivity laboratories. The exercise was organised according to the ISO-43 and the ISO/IUPAC/AOAC. Aphosphogypsum material was used as a test sample, in an attempt to evaluate the performance of the laboratories analyzing NORM (Naturally-Occurring Radioactive Materials). The analysis required were: U-238, Th-234, U-234, Th-230, Ra-226, Pb-214, Bi-214, Pb-210, Po-210, Th-232 and U-235, and also gross alpha and gross beta activities. Reference values have been established according to the method of consensus of expert laboratories, with four international laboratories of credited experience: IAEA Seibersdorf, IAEA MEL, IRSN-Orsay and Sta.Teresa ENEA. The results of the exercise were computed for 34 answering laboratories and their analytical performance was assessed using the z-score. Robust statistics of the participants results was applied to obtain the median and standard deviation, to achieve a more complete and objective study of the laboratories performance. The exercise has shown an homogeneous behaviour of laboratories, being statistical parameters from the results close to the assigned Reference Values. Participant laboratories have demonstrated their ability to determine natural radionuclides in phosphogypsum samples (NORM material) with a satisfactory quality level. The scheme has also allowed examining the capability of laboratories to determine the activities of natural radionuclides at the equilibrium. (Author) 10 refs.

  5. First results from the MACRO experiment at the Gran Sasso Laboratory

    The first physics results obtained with the MACRO detector in the underground Gran Sasso Laboratory are reported. Results were also obtained in conjunction with the EAS-TOP detector located on top of the Gran Sasso mountain. (orig.)

  6. Results of the Interlaboratory Exercise CNS/CIEMAT-04 Among Environmental Radioactivity Laboratories (Aqueous Solution)

    The document describes the outcome of the CSN/CIEMAT-04 interlaboratory test comparison among environmental radioactivity laboratories. The exercise was organised according to the ISO-43 and the ISO/IUPAC/AOAC Harmonised Protocol for the proficiency testing of analytical laboratories. Following the issue of the European Community Drinking Water Directive 98/83/EC concerning the quality of water for human consumption, the last inter-comparison exercise was organised by using a water sample, in an attempt to evaluate the performance of the laboratories analysing the required radioactivity parameters (H-3, gross alpha and beta activity and residual beta). The sample (a synthetic drinking water), was prepared at the National Laboratory for Ionising Radiation's Standards (CIEMAT), and contained the following radionuclides ''241 Am, ''239+240 Pu, ''90Sr, ''137 Cs, ''3 H y ''40 K. The results of the exercise were computed for 38 participating laboratories, and their analytical performance was assessed using the z-score approach. Robust statistics of the participant's results was applied to obtain the median and standard deviation, including suspected outliers. The exercise has revealed and homogeneous behaviour of laboratories, being statistical parameters from the results close to the reference values. A raised percentage os satisfactory laboratory performance has been obtained for gross alpha, gross beta and residual beta: 85, 97 and 87% respectively. The study has shown that participant laboratories perform radioactive determinations in drinking water samples with satisfactory quality levels. (Author) 16 refs

  7. Results of the Interlaboratory Exercise CNS/CIEMAT-05 among Environmental Radioactivity Laboratories (Vegetable Ash)

    The document describes the outcome of the CSN/CIEMAT-05 interlaboratory test comparison among environmental radioactivity laboratories. The exercise was organised according to the ISO-43 and the IUPAC International harmonised protocol for the proficiency testing of analytical chemistry laboratories. The exercise has been designed to evaluate the capability of national laboratories to determine environmental levels of radionuclides in vegetable ash samples. The sample has been prepared by the Environmental Radiation Laboratory, from the University of Barcelona, and it contains the following radionuclides: Sr-90, Pu-238, Am-241, Th-230, Pb-210, U-238, Ra-226, K-40, Ra-228, TI-208, Cs- 137 and Co-60. Reference values have been established TROUGH the kind collaboration of three international laboratories of recognized experience: IAEA MEL and IRSN-Orsay. The results of the exercise were computed for 35 participating laboratories and their analytical performance was assessed using the z-score approach. Robust statistics of the participant's results was applied to obtain the median and standard deviation, to achieve a more complete and objetiva study of the laboratories' performance. Some difficulties encountered to dissolve the test sample caused a lower response of analyses involving radiochemical separation, thus some laboratories couldn't apply their routine methods and no conclusions on PU-238, Am-241 and Th-230 performances have been obtained. The exercise has revealed an homogeneous behaviour of laboratories, being statistical parameters from the results close to the reference values. The study has shown that participant laboratories perform radioactive determinations in vegetable ash samples with satisfactory quality levels. (Author) 6 refs

  8. A new medium for physics teaching: results of a worldwide study of remotely controlled laboratories (RCLs)

    We report on the results of a worldwide research project on remotely controlled laboratories (RCLs). The findings are briefly commented on and critically reviewed. The survey of RCLs, together with the criteria of evaluation, can be downloaded. (letters and comments)

  9. Audit of a system for dealing with a practice's laboratory test results.

    Stephenson, P.

    1993-01-01

    In order to improve efficiency in a non-computerized practice of 4700 patients the system for dealing with laboratory test results and communicating them to patients was audited over a two-week period. The audit involved a questionnaire for the practice team, a postal questionnaire to 36 patients, and an analysis of doctors' and receptionists' workload when dealing with laboratory test results. A new system was introduced, with two receptionists logging investigation details into a newly desi...

  10. Congenital Abnormalities

    ... blood flow to the fetus impair fetal growth. Alcohol consumption and certain drugs during pregnancy significantly increase the risk that a baby will be born with abnormalities (e.g. fetal alcohol spectrum disorders ). Eating raw or uncooked foods during pregnancy can also be dangerous to health of the ...

  11. Results of the Interlaboratory Exercise CSN/CIEMAT-02 Among Environmental Radioactivity Laboratories (Sea Fish)

    The document describes the outcome of the CSN/CIEMAT-02 interlaboratory test comparison among environmental radioactivity laboratories. The exercise was organised according to the ISO-43 and the ISO/IUPAC/AOAC Harmonized Protocol for the proficiency testing of analytical laboratories. The test sample was a reference materials provided by the IAEA-MEL (IAE Marine Environmental Laboratory, Monaco), a sea fish containing environmental levels of U-238, U-234, K-40, Pb-210, Ra-226, Sr-90, Cs-137, Co-60, Pu-(239+240), Am-241 and Tc-99. The results of the exercise were computed for 32 participating laboratories, and their analytical performance was assessed using the z-score approach. A raised percentage of satisfactory laboratory performance has been obtained for all the analysis, being the best performance in gamma measurements. The laboratories have made an effort to calculate the combined uncertainty of the radiochemical determinations. Most of the laboratories have demonstrated its competence in performing the study analysis and also the adequate measuring capability of their detection equipment even in conditions close to detection limits. The study has shown the capacity of participant laboratories to perform radioactive determinations in environmental sea fish samples with satisfactory quality levels. (Author) 6 refs

  12. Modulation of centimetric waves by long gravity waves - Progress report on field and laboratory results

    Shemdin, O. H.

    1978-01-01

    Results are presented from laboratory and field experiments on the modulation of short waves by long waves. The field study employed a wave follower capable of tracking ocean waves with frequencies less than 1.0 Hz and heights less than 2.0 m. A high-response laser-optical system was used to detect upwind-downwind and cross-wind slopes of short waves. The laboratory study was conducted with wind over periodic long waves. The laboratory findings are discussed and compared with laboratory radar measurements and also short wave measurements obtained in the field. It is found that long waves significantly modulate the short wave dispersion by their orbital velocity, and that demodulation is necessary if the data collected by remote sensors are to be compared to surface penetrating devices. The modulation level is weak for wavelengths in the range 2.76-3.30 cm. Other relevant results are also presented.

  13. Computer-Aided Generation of Result Text for Clinical Laboratory Texts

    Kuzmak, Peter M.; Miller, R. E.

    1983-01-01

    Efficient processing of non-numeric textual data is a frequent requirement with medical computer applications such as clinical laboratory result reporting. In such instances, it is often desirable that the computer control the generation of the text to ensure that the intended meaning is conveyed. This paper describes a technique for interactively selecting predefined text segments to form complex textual reports for laboratory tests. The approach, which uses algorithms based on augmented tra...

  14. Results of the REIMEP-17 and NUSIMEP-8 inter-laboratory comparisons

    JAKOPIC Rozle; BUJAK RENATA; Aregbe, Yetunde; Richter, Stephan; BUDA RAZVAN; Zuleger, Evelyn

    2014-01-01

    Confidence in measurement results is established via reference materials, reference measurements and inter-laboratory comparisons. The Institute for Reference Materials and Measurements of the Joint Research Centre of the European Commission (EC-JRC-IRMM) has a long time experience in the development of nuclear isotopic reference materials and in the organisation of inter-laboratory comparisons (ILCs) in compliance with the respective international ISO guides. The Regular European Inter-labor...

  15. A splice site mutation in laminin-α2 results in a severe muscular dystrophy and growth abnormalities in zebrafish.

    Vandana A Gupta

    Full Text Available Congenital muscular dystrophy (CMD is a clinically and genetically heterogeneous group of inherited muscle disorders. In patients, muscle weakness is usually present at or shortly after birth and is progressive in nature. Merosin deficient congenital muscular dystrophy (MDC1A is a form of CMD caused by a defect in the laminin-α2 gene (LAMA2. Laminin-α2 is an extracellular matrix protein that interacts with the dystrophin-dystroglycan (DGC complex in membranes providing stability to muscle fibers. In an N-ethyl-N-nitrosourea mutagenesis screen to develop zebrafish models of neuromuscular diseases, we identified a mutant fish that exhibits severe muscular dystrophy early in development. Genetic mapping identified a splice site mutation in the lama2 gene. This splice site is highly conserved in humans and this mutation results in mis-splicing of RNA and a loss of protein function. Homozygous lama2 mutant zebrafish, designated lama2(cl501/cl501, exhibited reduced motor function and progressive degeneration of skeletal muscles and died at 8-15 days post fertilization. The skeletal muscles exhibited damaged myosepta and detachment of myofibers in the affected fish. Laminin-α2 deficiency also resulted in growth defects in the brain and eye of the mutant fish. This laminin-α2 deficient mutant fish represents a novel disease model to develop therapies for modulating splicing defects in congenital muscular dystrophies and to restore the muscle function in human patients with CMD.

  16. Compound heterozygosity for a dominant glycine substitution and a recessive internal duplication mutation in the type XVII collagen gene results in junctional epidermolysis bullosa and abnormal dentition.

    McGrath, J A; Gatalica, B; Li, K; Dunnill, M G; McMillan, J R; Christiano, A M; Eady, R A; Uitto, J

    1996-06-01

    Junctional epidermolysis bullosa is a heterogeneous autosomal recessively inherited blistering skin disorder associated with fragility at the dermal-epidermal junction. Previously, mutations in this condition have been described in the three genes for the anchoring filament protein laminin 5 (LAMA3, LAMB3, and LAMC2), in the gene encoding the hemidesmosome-associated beta4 integrin (ITGB4), and in the gene for the hemidesmosomal protein type XVII collagen (COL17A1/BPAG2). In this study, we report a patient with a form of junctional epidermolysis bullosa with skin fragility and dental anomalies who is a compound heterozygote for a novel combination of mutations, ie, a glycine substitution mutation in one allele and an internal duplication in the other allele of COL17A1. The patient also has two offspring, both of whom have inherited the glycine substitution mutation, whereas the other COL17A1 allele is normal. The latter individuals show no evidence of skin fragility but have marked dental abnormalities with enamel hypoplasia and pitting. The clinical phenotype of junctional epidermolysis bullosa in the proband in this family probably arises due to a combination of the glycine substitution and the internal duplication in COL17A1, whereas the dental abnormalities of her offspring may be the result of the glycine substitution in COL17A1 alone, resulting in this dominantly inherited clinical phenotype. PMID:8669466

  17. Methods of Estimation the Reliability and Increasing the Informativeness of the Laboratory Results (Analysis of the Laboratory Case of Measurement the Indicators of Thyroid Function

    N A Kovyazina

    2014-06-01

    Full Text Available The goal of the study was to demonstrate the multilevel laboratory quality management system and point at the methods of estimating the reliability and increasing the amount of information content of the laboratory results (on the example of the laboratory case. Results. The article examines the stages of laboratory quality management which has helped to estimate the reliability of the results of determining Free T3, Free T4 and TSH. The measurement results are presented by the expanded uncertainty and the evaluation of the dynamics. Conclusion. Compliance with mandatory measures for laboratory quality management system enables laboratories to obtain reliable results and calculate the parameters that are able to increase the amount of information content of laboratory tests in clinical decision making.

  18. Prevalence of asymptomatic urinary abnormalities among adolescents

    Mohamed Fouad

    2016-01-01

    Full Text Available To determine the prevalence of asymptomatic urinary abnormalities in adolescents, first morning clean mid-stream urine specimens were obtained from 2500 individuals and examined by dipstick and light microscopy. Adolescents with abnormal screening results were reexamined after two weeks and those who had abnormal results twice were subjected to systemic clinical examination and further clinical and laboratory investigations. Eight hundred and three (32.1% individuals had urinary abnormalities at the first screening, which significantly decreased to 345 (13.8% at the second screening, (P <0.001. Hematuria was the most common urinary abnormalities detected in 245 (9.8% adolescents who had persistent urine abnormalities; 228 (9.1% individuals had non glomerular hematuria. The hematuria was isolated in 150 (6% individuals, combined with leukocyturia in 83 (3.3% individuals, and combined with proteinuria in 12 (0.5% individuals. Leukocyturia was detected in 150 (6% of all studied adolescents; it was isolated in 39 (1.6% individuals and combined with proteinuria in 28 (1.1% of them. Asymp- tomatic bacteriuria was detected in 23 (0.9% of all studied adolescents; all the cases were females. Proteinuria was detected in 65 (2.6% of all the studied adolescents; 45 (1.8% indivi- duals had <0.5 g/day and twenty (0.8% individuals had 0.5-3 g/day. Asymptomatic urinary abnormalities were more common in males than females and adolescents from rural than urban areas (P <0.01 and (P <0.001, respectively. The present study found a high prevalence of asymptomatic urinary abnormalities among adolescents in our population.

  19. Results of the Interlaboratory Exercise CSN/CIEMAT-100 Among Environmental Radioactivity Laboratories (Soil)

    The document describes the outcome of the CSN/CIEMAT-00 interlaboratory test comparison among environmental radioactivity laboratories. the exercise was organised according to the ISO-43 and the ISO/IUPAC/AOAC Harmonized Protocol for the proficiency testing of analytical laboratories. the test sample was a soil containing environmental levels of K-40, Ra-226, Ac-228, Sr-90, Cs-137, Cs-134, Pu (239-240) y Am-241. the Universidad Autonoma de Barcelona prepared the material and reported adequate statistical studies of homogeneity. The results of the exercise were computed for 30 participating laboratories, and their analytical performance was assessed using the u-score approach. A raised percentage of satisfactory laboratory performance has been obtained for all the analysis, being the best performance in gamma measurements. The exercise has drawn that several laboratories have difficulties in the evaluation of combined uncertainty, mainly in analysis involving radiochemical steps. The study has shown an homogeneous inter-laboratory behaviour, and the improvement achieved through subsequent exercises in the quality of the data they are producing. (Author) 10 refs

  20. Possibility to predict early postpartum glucose abnormality following gestational diabetes mellitus based on the results of routine mid-gestational screening

    Bartáková, Vendula; Malúšková, Denisa; Mužík, Jan; Bělobrádková, Jana; Kaňková, Kateřina

    2015-01-01

    Introduction: Women with previous gestational diabetes mellitus (GDM) have increased risk of developing glucose abnormality, but current diagnostic criteria are evidence-based for adverse pregnancy outcome. The aims of our study were: (i) to ascertain a frequency of early conversion of GDM into permanent glucose abnormality, (ii) to determine predictive potential of current GDM diagnostic criteria for prediction of postpartum glucose abnormality and (iii) to find optimal cut-off values of ora...

  1. Pseudo-Outbreak of Rhizobium radiobacter Infection Resulting from Laboratory Contamination of Saline Solution▿

    Pereira, Lynette A.; Chan, Douglas Su Gin; Ng, Toon Mae; Lin, Raymond; Jureen, Roland; Fisher, Dale A; Tambyah, Paul A.

    2009-01-01

    We report a pseudo-outbreak of Rhizobium radiobacter infections resulting from contamination by a saline dispenser in the microbiology laboratory. Isolates from clinical specimens had identical antimicrobial susceptibilities and electrophoretic fingerprints. The episode resolved with autoclaving of the dispenser. This demonstrates the importance of timely, thorough investigation of unusual organisms, particularly when they appear as a cluster.

  2. Preliminary results from a laboratory study of charging mechanisms in a dusty plasma

    A laboratory investigation has been developed to experimentally study the interaction of micron sized particles with plasmas and electromagnetic radiation. The intent is to investigate under what conditions particles of various compositions and sizes become charged, or discharged, while exposed to an electron beam. Primary emphasis in this report is on secondary emission of electrons. Preliminary results are presented

  3. Auditory localisation of conventional and electric cars : laboratory results and implications for cycling safety

    Stelling-Konczak, A. Hagenzieker, M.P. Commandeur, J.J.F. Agterberg, M.J.H. & Wee, B. van

    2016-01-01

    When driven at low speeds, cars operating in electric mode have been found to be quieter than conventional cars. As a result, the auditory cues which pedestrians and cyclists use to assess the presence, proximity and location oncoming traffic may be reduced, posing a safety hazard. This laboratory s

  4. Results of measurements at a laboratory condensation heat exchanger with a corrugated minichanel tube

    Jan Hrubý; Pavel Peukert

    2012-01-01

    This article present a short selection of results obtained from measurements done at a laboratory condensation heat-exchanger with a corrugated mini-channel tube. It also touches a little the metering method and design of the heat-exchanger.

  5. Results of measurements at a laboratory condensation heat exchanger with a corrugated minichanel tube

    Jan Hrubý

    2012-04-01

    Full Text Available This article present a short selection of results obtained from measurements done at a laboratory condensation heat-exchanger with a corrugated mini-channel tube. It also touches a little the metering method and design of the heat-exchanger.

  6. A laboratory instrument for determination of ash in brown coal and some results of its testing

    A computer controlled laboratory instrument for the determination of ash as well as calcium and iron oxides in brown coals has been developed. It consists of a measuring head, control unit and printing device. Its principle of operation is based on XRF and scattering of the low energy X-rays from a Pu-238 source. Algorithms of the operation, software and design of the instrument are described. Some results of its testing are provided. The instrument is designed for the application in laboratories of power plants and brown coal mines. 6 refs., 5 figs., 1 tab. (author)

  7. Report of the research results with University of Tokyo, Nuclear Engineering Research Laboratory's Facilities in fisical 1985

    The common utilization of the reactor 'Yayoi' and the electron linear accelerator in the Nuclear Engineering Research Laboratory advanced smoothly in fiscal year 1985. 21 themes using the reactor 'Yayoi' and of the related research and 23 themes using the linear accelerator were carried out, and the excellent results were obtained. As for the Yayoi, after the repair, abnormality was not found at all in the regular inspection, and it has been operated smoothly. As for the linear accelerator, in spite of the occurrence of troubles due to the remarkable secular deterioration after the lapse of ten years, rapid countermeasures were taken, accordingly, the expected machine time was used nearly 100 %. Due to the addition of new themes and the expansion of users, it is difficult to ensure sufficient machine time in the common utilization, but to devise the efficient use in future by putting the peripheral equipment in order and simultaneously carrying out plural themes is the subject. Several cases of the joint experiment with foreign researchers were also carried out. In this report, also eight cases of the short period study meetings held in fiscal year 1985 are included. (Kako, I.)

  8. Publication bias in laboratory animal research by non-publication of “negative” results

    van Noorden, Cornelis J. F.

    2013-01-01

    An interesting publication for the readership of The All Results Journal appeared recently, focused on publication bias in laboratory animal research. The article highlight the preference to publish results that show effects of treatment over publication of lack of effects of treatment. The authors do not have hard evidence for the preference to publish effects rather than the lack of effects but show indirect evidence for this phenomenon by ...

  9. Testing mechanical properties of food powders in two laboratories - degree of consistency of results

    F. Ayuga

    2006-03-01

    Full Text Available Two research groups conducted experiments on the mechanical properties of granular materials of plant origin in two distant laboratories without mutual knowledge about running similar projects. Recently established cooperation of a Spanish research group led by Ayuga and Polish research group led by Horabik allowed for in-depth comparison of results. Materials tested in two locations were: wheat, lentils, rapeseeds, sugar and wheat meal. Material characteristics determined were: strength properties (the angle of internal friction, j and the cohesion, c, the modulus of elasticity, E and the Poisson’s ratio, n. Test equipments applied were: direct shear, triaxial compression and uniaxial compression apparatuses. In general, analysis of results of testing in the two laboratories have shown that to obtain consistent results strict concordance in material state, equipment and test conditions is necessary. To resolve the problem standardization of parameters and methods of their determination should be undertaken on an international level.

  10. Test Results From The Idaho National Laboratory Of The NASA Bi-Supported Cell Design

    C Stoots; J O' Brien; T Cable

    2009-11-01

    The Idaho National Laboratory has been researching the application of solid-oxide fuel cell technology for large-scale hydrogen production. As a result, the Idaho National Laboratory has been testing various cell designs to characterize electrolytic performance. NASA, in conjunction with the University of Toledo, has developed a new cell concept with the goals of reduced weight and high power density. This paper presents results of the INL's testing of this new solid oxide cell design as an electrolyzer. Gas composition, operating voltage, and other parameters were varied during testing. Results to date show the NASA cell to be a promising design for both high power-to-weight fuel cell and electrolyzer applications.

  11. High acceptability for cell phone text messages to improve communication of laboratory results with HIV-infected patients in rural Uganda: a cross-sectional survey study

    Siedner Mark J

    2012-06-01

    Full Text Available Abstract Background Patient-provider communication is a major challenge in resource-limited settings with large catchment areas. Though mobile phone usership increased 20-fold in Africa over the past decade, little is known about acceptability of, perceptions about disclosure and confidentiality, and preferences for cell phone communication of health information in the region. Methods We performed structured interviews of fifty patients at the Immune Suppression Syndrome clinic in Mbarara, Uganda to assess four domains of health-related communication: a cell phone use practices and literacy, b preferences for laboratory results communication, c privacy and confidentiality, and d acceptability of and preferences for text messaging to notify patients of abnormal test results. Results Participants had a median of 38 years, were 56% female, and were residents of a large catchment area throughout southwestern Uganda. All participants expressed interest in a service to receive information about laboratory results by cell phone text message, stating benefits of increased awareness of their health and decreased transportation costs. Ninety percent reported that they would not be concerned for unintended disclosure. A minority additionally expressed concerns about difficulty interpreting messages, discouragement upon learning bad news, and technical issues. Though all respondents expressed interest in password protection of messages, there was also a strong desire for direct messages to limit misinterpretation of information. Conclusions Cell phone text messaging for communication of abnormal laboratory results is highly acceptable in this cohort of HIV-infected patients in rural Uganda. The feasibility of text messaging, including an optimal balance between privacy and comprehension, should be further studied.

  12. Accuracy and repeatability of weighing for occupational hygiene measurements: results from an inter-laboratory comparison.

    Stacey, Peter; Revell, Graham; Tylee, Barry

    2002-11-01

    Gravimetric analysis is a fundamental technique frequently used in occupational hygiene assessments, but few studies have investigated its repeatability and reproducibility. Four inter-laboratory comparisons are discussed in this paper. The first involved 32 laboratories weighing 25 mm diameter glassfibre filters, the second involved 11 laboratories weighing 25 mm diameter PVC filters and the third involved eight laboratories weighing plastic IOM heads with 25 mm diameter glassfibre filters. Data from the third study found that measurements using this type of IOM head were unreliable. A fourth study, to ascertain if laboratories could improve their performance, involved a selected sub-group of 10 laboratories from the first exercise that analysed the 25 mm diameter glassfibre filters. The studies tested the analytical measurement process and not just the variation in weighings obtained on blank filters, as previous studies have done. Graphs of data from the first and second exercises suggest that a power curve relationship exists between reproducibility and loading and repeatability and loading. The relationship for reproducibility in the first study followed the equation log s(R) = -0.62 log m + 0.86 and in the second study log s(R) = -0.64 log m + 0.57, where s(R) is the reproducibility in terms of per cent relative standard deviation (%RSD) and m is the weight of loading in milligrams. The equation for glassfibre filters from the first exercise suggested that at a measurement of 0.4 mg (about a tenth of the United Kingdom legislative definition of a hazardous substance for a respirable dust for an 8 h sample), the measurement reproducibility is more than +/-25% (2sigma). The results from PVC filters had better repeatability estimates than the glassfibre filters, but overall they had similar estimates of reproducibility. An improvement in both the reproducibility and repeatability for glassfibre filters was observed in the fourth study. This improvement reduced

  13. Report concerning results of proficiency testing laboratory on assay of tobramycine and nystatin by microbiological method

    Simona Sturzu

    2013-05-01

    Full Text Available The present study describes the results obtained by the Microbiological Control Laboratory from Institute for Control of Biological Products and Veterinary Medicines after participating in the proficiency testing scheme study on microbiological assay of nystatin and tobramycin. The proficiency testing scheme was organized by European Directorate for the Quality of Medicines and Health Care. The microbiological method consisted of a cylinderplate agar diffusion assay using Bacillus subtilis ATCC 6633 for tobramycin and Saccharomyces cerevisiae for nystatin as the test microorganism. The means of results were 108.70 % of label claim for nystatin and 104.70%of label claim for tobramicin. The Z scores were 0.14 for tobramycin and 1.40 for nystatin, the assigned value used for booth samples was 105.4% for tobramycin and 101.7% for nystatin. The performance of Microbiological Control Laboratory was very good for both samples.

  14. Small Wind Turbine Testing Results from the National Renewable Energy Laboratory: Preprint

    Bowen, A.; Huskey, A.; Link, H.; Sinclair, K.; Forsyth, T.; Jager, D.; van Dam, J.; Smith, J.

    2010-04-01

    In 2008, the U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL) began testing small wind turbines (SWTs) through the Independent Testing project. Using competitive solicitation, five SWTs were selected for testing at the National Wind Technology Center (NWTC). NREL's NWTC is accredited by the American Association of Laboratory Accreditation (A2LA) to conduct duration, power performance, safety and function, power quality, and noise tests to International Electrotechnical Commission (IEC) standards. Results of the tests conducted on each of the SWTs are or will be available to the public on the NREL website. The results could be used by their manufacturers in the certification of the turbines or state agencies to decide which turbines are eligible for state incentives.

  15. Results of inter corporation measurements in radiometric laboratory with implemented quality assurance system

    Radioactivity is one of the natural hazards occurring in Polish mines. Particularly for this hazard the control system should ensure reliable of measurements.For this purpose internal quality assurance systems are introduced to laboratories dealing with measurements of radioactivity. In the framework of implementation of the quality assurance system the laboratory of radiometry of the Central Mining Institute has been involved in two intercomparison systems organized by IAEA and EPA. Those systems deal with measurements of natural and artificial radioactivity of solid and liquid samples. For radon and its daughters similar intercomparisons with many participants, are more difficult to be carried out. Therefore in such cases bilateral intercomparisons are performed. The presented results of the intercomparisons have been pointed out that the internal quality assurance system ensures the obtaining of correct results. On the other hand the intercomparisons permit to check the applied research procedures. (author). 16 refs, 2 figs, 6 tabs

  16. Flammability of litter sampled according to two different methods: comparison of results in laboratory experiments

    Ganteaume, A.; Jappiot, M.; Curt, T.; Lampin, C.; Borgniet, L.

    2014-01-01

    In the laboratory, different types of litter samples (constructed v. intact) can be used in flammability experiments but the sampling method of these litters could affect litter flammability results. To assess this effect, samples of litters were collected in South-eastern France, according to two different methods previously used in other studies, one keeping intact the structure of the litter layers (non-constructed litter) and the other requiring the construction of the litter, using mainl...

  17. Detection of Pathogenic Protozoa in the Diagnostic Laboratory: Result Reproducibility, Specimen Pooling, and Competency Assessment▿

    Libman, M D; GYORKOS, T. W.; Kokoskin, E.; MacLean, J. D.

    2008-01-01

    Stool microscopy as performed in clinical parasitology laboratories is a complex procedure with subjective interpretation. Quality assurance (QA) programs often emphasize proficiency testing as an assessment tool. We describe a result reproducibility assessment tool, which can form part of a broader QA program, and which is based on the blinded resubmission of selected clinical samples, using concordance between the reports of the initial and resubmitted specimen as an indicator. Specimens pr...

  18. Auditory localisation of conventional and electric cars : laboratory results and implications for cycling safety

    Stelling-Konczak, A. & Hagenzieker, M.P.

    2016-01-01

    When driven at low speeds, cars operating in electric mode have been found to be quieter than conventional cars. As a result, the auditory cues which pedestrians and cyclists use to assess the presence, proximity and location oncoming traffic may be reduced, posing a safety hazard. This laboratory study examined auditory localisation of conventional and electric cars including vehicle motion paths relevant for cycling activity. Participants (N = 65) in three age groups (16–18, 30–40 and 65–70...

  19. Testing mechanical properties of food powders in two laboratories - degree of consistency of results

    Ayuga, F.; Horabik, J.; Ramirez, A.; Moya, M.; Stasiak, M.; Molenda, M.

    2006-01-01

    Two research groups conducted experiments on the mechanical properties of granular materials of plant origin in two distant laboratories without mutual knowledge about running similar projects. Recently established cooperation of a Spanish research group led by Ayuga and Polish research group led by Horabik allowed for in-depth comparison of results. Materials tested in two locations were: wheat, lentils, rapeseeds, sugar and wheat meal. Material characteristics determined were: strength prop...

  20. Results from laboratory tests of the two-dimensional Time-Encoded Imaging System.

    Marleau, Peter; Brennan, James S.; Brubaker, Erik; Gerling, Mark D; Le Galloudec, Nathalie Joelle

    2014-09-01

    A series of laboratory experiments were undertaken to demonstrate the feasibility of two dimensional time-encoded imaging. A prototype two-dimensional time encoded imaging system was designed and constructed. Results from imaging measurements of single and multiple point sources as well as extended source distributions are presented. Time encoded imaging has proven to be a simple method for achieving high resolution two-dimensional imaging with potential to be used in future arms control and treaty verification applications.

  1. Quality Assessment of Urinary Stone Analysis: Results of a Multicenter Study of Laboratories in Europe.

    Roswitha Siener

    Full Text Available After stone removal, accurate analysis of urinary stone composition is the most crucial laboratory diagnostic procedure for the treatment and recurrence prevention in the stone-forming patient. The most common techniques for routine analysis of stones are infrared spectroscopy, X-ray diffraction and chemical analysis. The aim of the present study was to assess the quality of urinary stone analysis of laboratories in Europe. Nine laboratories from eight European countries participated in six quality control surveys for urinary calculi analyses of the Reference Institute for Bioanalytics, Bonn, Germany, between 2010 and 2014. Each participant received the same blinded test samples for stone analysis. A total of 24 samples, comprising pure substances and mixtures of two or three components, were analysed. The evaluation of the quality of the laboratory in the present study was based on the attainment of 75% of the maximum total points, i.e. 99 points. The methods of stone analysis used were infrared spectroscopy (n = 7, chemical analysis (n = 1 and X-ray diffraction (n = 1. In the present study only 56% of the laboratories, four using infrared spectroscopy and one using X-ray diffraction, fulfilled the quality requirements. According to the current standard, chemical analysis is considered to be insufficient for stone analysis, whereas infrared spectroscopy or X-ray diffraction is mandatory. However, the poor results of infrared spectroscopy highlight the importance of equipment, reference spectra and qualification of the staff for an accurate analysis of stone composition. Regular quality control is essential in carrying out routine stone analysis.

  2. Large Volume Calorimeter Comparison Measurement Results Collected at the Los Alamos National Laboratory Plutonium Facility.

    Bracken, D. S. (David S.)

    2005-01-01

    A calorimeter capable of measuring the power output from special nuclear material in 208-liter (55-gal) shipping or storatge containers was designed and fabricated at Los Alamos National Laboratory (LANL). This high-sensitivity, large-volume calorimeter (LVC) provides a reliable NDA method to measure many difficult-to-assay forms of plutonium and tritium more accurately. The entire calorimeter is 104 cm wide x 157 cm deep x 196 cm high in the closed position. The LVC also requires space for a standard electronics rack. A standard 208-1 drum with a 60-cm-diameter retaining ring with bolt will fit into the LVC measurement chamber. With careful positioning, cylindrical items up to 66 cm in diameter and 100 cm tall can be assayed in the LVC. The LVC was used to measure numerous plutonium-bearing items in 208-1 drums at the Los Alamos Plutonium Facility. Measurement results from real waste drums that were previously assayed using multiple NDA systems are compared with the LVC results. The calorimeter previously performed well under laboratory conditions using Pu-238 heat standards. The in-plant instrument performance is compared with the laboratory performance. Assay times, precision, measurement threshold, and operability of the LVC are also presented.

  3. Large Volume Calorimeter Comparison Measurement Results Collected at the Los Alamos National Laboratory Plutonium Facility

    A calorimeter capable of measuring the power output from special nuclear material in 208-liter (55-gal) shipping or storatge containers was designed and fabricated at Los Alamos National Laboratory (LANL). This high-sensitivity, large-volume calorimeter (LVC) provides a reliable NDA method to measure many difficult-to-assay forms of plutonium and tritium more accurately. The entire calorimeter is 104 cm wide x 157 cm deep x 196 cm high in the closed position. The LVC also requires space for a standard electronics rack. A standard 208-1 drum with a 60-cm-diameter retaining ring with bolt will fit into the LVC measurement chamber. With careful positioning, cylindrical items up to 66 cm in diameter and 100 cm tall can be assayed in the LVC. The LVC was used to measure numerous plutonium-bearing items in 208-1 drums at the Los Alamos Plutonium Facility. Measurement results from real waste drums that were previously assayed using multiple NDA systems are compared with the LVC results. The calorimeter previously performed well under laboratory conditions using Pu-238 heat standards. The in-plant instrument performance is compared with the laboratory performance. Assay times, precision, measurement threshold, and operability of the LVC are also presented.

  4. Clinical results of stereotactic hellium-ion radiosurgery of the pituitary gland at Lawrence Berkeley Laboratory

    Levy, R.P.; Fabrikant, J.I.; Lyman, J.T.; Frankel, K.A.; Phillips, M.H.; Lawrence, J.H.; Tobias, C.A.

    1989-12-01

    The first therapeutic clinical trial using accelerated heavy-charged particles in humans was performed at Lawrence Berkeley Laboratory (LBL) for the treatment of various endocrine and metabolic disorders of the pituitary gland, and as suppressive therapy for adenohypophyseal hormone-responsive carcinomas and diabetic retinopathy. In acromegaly, Cushing's disease, Nelson's syndrome and prolactin-secreting tumors, the therapeutic goal in the 433 patients treated has been to destroy or inhibit the growth of the pituitary tumor and control hormonal hypersecretion, while preserving a functional rim of tissue with normal hormone-secreting capacity, and minimizing neurologic injury. An additional group of 34 patients was treated for nonsecreting chromophobe adenomas. This paper discusses the methods and results of stereotactic helium-ion radiosurgery of the pituitary gland at Lawrence Berkeley Laboratory. 11 refs.

  5. Clinical results of stereotactic hellium-ion radiosurgery of the pituitary gland at Lawrence Berkeley Laboratory

    The first therapeutic clinical trial using accelerated heavy-charged particles in humans was performed at Lawrence Berkeley Laboratory (LBL) for the treatment of various endocrine and metabolic disorders of the pituitary gland, and as suppressive therapy for adenohypophyseal hormone-responsive carcinomas and diabetic retinopathy. In acromegaly, Cushing's disease, Nelson's syndrome and prolactin-secreting tumors, the therapeutic goal in the 433 patients treated has been to destroy or inhibit the growth of the pituitary tumor and control hormonal hypersecretion, while preserving a functional rim of tissue with normal hormone-secreting capacity, and minimizing neurologic injury. An additional group of 34 patients was treated for nonsecreting chromophobe adenomas. This paper discusses the methods and results of stereotactic helium-ion radiosurgery of the pituitary gland at Lawrence Berkeley Laboratory. 11 refs

  6. Fine-needle aspiration cytology in nonpalpable mammographic abnormalities in breast cancer screening: results from the breast cancer screening programme in Oslo 1996-2001.

    Sauer, Torin; Myrvold, Kristina; Lømo, Jon; Anderssen, Karin Yvonne; Skaane, Per

    2003-10-01

    Fine-needle aspiration cytology (FNAC) of nonpalpable mammographic lesions has been under attack from two sides for some years. There has been much discussion and controversy as to the ability to differentiate between in situ and invasive carcinomas in cytological material. A further issue is that of optimal sampling to obtain adequate cell material in sufficient quantity. We present the results of FNAC from 832 nonpalpable mammographic abnormalities detected in the course of the breast cancer screening programme in Oslo during 1996-2001. In 11.6% of cases the smears were inadequate, and there were 7% false negatives (FN) and 1.3% false positives. Of the FN, 64% represented microcalcifications and 86% were due to sampling errors. Absolute sensitivity was 74%, complete sensitivity 88% and specificity 88%. In 255 carcinomas a cytological diagnosis of them as in situ or invasive was made. In 93% of the invasive cases (190/205) these had been correctly identified as invasive on FNAC. In 78% of cases proper follow-up could be resolved by cytology/radiology alone. Suboptimal sampling and localization remains the main cause of FN FNAC results. Problems in differentiating between in situ and invasive breast carcinomas can be significantly reduced by applying strict criteria for in situ lesions. PMID:14659146

  7. Results of intercalibration exercises on low-level radionuclide measurements by Cresp participating laboratories

    Intercomparison of analyses on radionuclides at low-levels by analysts of the CRESP group shows generally good concordance with accepted values were known. During the review period several analysis results were collected for a deep sea sample of sediment which was used as a control. Although confirming the sample as a useful laboratory blank for artificial radionuclides, where are not yet sufficient analyses to give certified values for those nuclides. The number of results submitted is smaller than normal for a CRESP intercomparison, which may be attributable to the heavy work load following the Chernobyl accident

  8. Pre-analytical factors affecting the results of laboratory blood analyses in farm animal veterinary diagnostics.

    Humann-Ziehank, E; Ganter, M

    2012-07-01

    The quality of the laboratory diagnostic approach in farm animals can be severely affected by pre-analytical factors of variation. They induce increase/decrease of biochemical and hematological analyte concentrations and, as a consequence, they may cause unsuitable conclusions and decisions for animal health management and research projects. The pre-analytical period covers the preparation of sampling, the sampling procedure itself, as well as all specimen handling until the beginning of the specific laboratory analysis. Pre-analytical factors may have either an animal-related or a technique-related background. Animal-related factors cover daytime/season, meals/fasting, age, gender, altitude, drugs/anesthesia, physical exercise/stress or coinfection. Technique-related factors are the choice of the tube including serum v. plasma, effects of anticoagulants/gel separators, the anticoagulant/blood ratio, the blood collection procedure itself, specimen handling, contamination, labeling, storage and serum/plasma separation, transportation of the specimen, as well as sample preparation before analysis in the laboratory. It is essential to have proper knowledge about the importance and source of pre-analytical factors to alter the entire diagnostic process. Utmost efforts should be made to minimize controllable factors. Analytical results have to be evaluated with care considering that pre-analytical factors of variation are possible causes of misinterpretation. PMID:23031472

  9. Prevalence of undiagnosed abnormal glucose tolerance in adult patients cared for by general practitioners in Hungary. Results of a risk-stratified screening based on FINDRISC questionnaire

    Winkler, Gábor; Hidvégi, Tibor; Vándorfi, Győző; Balogh, Sándor; Jermendy, György

    2013-01-01

    Background The prevalence of type 2 diabetes mellitus is rapidly increasing, worldwide and also in Hungary. Timely diagnosis and early treatment could be aided by targeted screening. Recognizing this, the Hungarian Diabetes Association initiated a risk-stratified screening with the involvement of primary care physicians. Material/Methods In the first phase of screening, the FINDRISC questionnaire was completed, followed by an oral glucose tolerance test (OGTT) for those with a score of ≥12. Between September 1, 2010 and March 31, 2011, 70,432 non-diabetic adults, who visited their general practitioners for any reason, were involved in the screening. Of these, 68,476 questionnaires proved to be suitable for processing. Results From the questionnaires, 28,077 (41.0%) had a score of ≥12. A valid OGTT was performed in 22,846 cases; of this group 3,217 subjects (14.1%) had elevated fasting glucose levels, 5,663 (24.8%) had impaired glucose tolerance, and 1,750 (7.6%) had manifest, previously undiagnosed, diabetes mellitus. Overall, from the valid OGTT group, 46.5% subjects had some degree of glucose intolerance. Conclusions Based on the FINDRISC questionnaire, the risk-stratified screening for diabetes mellitus proved to be simple and cost-effective method for the early detection of carbohydrate metabolism disorders. Using this method, the prevalence rate of previously undiagnosed abnormal glucose tolerance was high in adult patients cared for by general practitioners in Hungary. PMID:23344680

  10. Integrating monitor alarms with laboratory test results to enhance patient deterioration prediction.

    Bai, Yong; Do, Duc H; Harris, Patricia Rae Eileen; Schindler, Daniel; Boyle, Noel G; Drew, Barbara J; Hu, Xiao

    2015-02-01

    Patient monitors in modern hospitals have become ubiquitous but they generate an excessive number of false alarms causing alarm fatigue. Our previous work showed that combinations of frequently co-occurring monitor alarms, called SuperAlarm patterns, were capable of predicting in-hospital code blue events at a lower alarm frequency. In the present study, we extend the conceptual domain of a SuperAlarm to incorporate laboratory test results along with monitor alarms so as to build an integrated data set to mine SuperAlarm patterns. We propose two approaches to integrate monitor alarms with laboratory test results and use a maximal frequent itemsets mining algorithm to find SuperAlarm patterns. Under an acceptable false positive rate FPRmax, optimal parameters including the minimum support threshold and the length of time window for the algorithm to find the combinations of monitor alarms and laboratory test results are determined based on a 10-fold cross-validation set. SuperAlarm candidates are generated under these optimal parameters. The final SuperAlarm patterns are obtained by further removing the candidates with false positive rate>FPRmax. The performance of SuperAlarm patterns are assessed using an independent test data set. First, we calculate the sensitivity with respect to prediction window and the sensitivity with respect to lead time. Second, we calculate the false SuperAlarm ratio (ratio of the hourly number of SuperAlarm triggers for control patients to that of the monitor alarms, or that of regular monitor alarms plus laboratory test results if the SuperAlarm patterns contain laboratory test results) and the work-up to detection ratio, WDR (ratio of the number of patients triggering any SuperAlarm patterns to that of code blue patients triggering any SuperAlarm patterns). The experiment results demonstrate that when varying FPRmax between 0.02 and 0.15, the SuperAlarm patterns composed of monitor alarms along with the last two laboratory test results

  11. Chromosome Abnormalities

    ... are two kinds of cell division, mitosis and meiosis. Mitosis results in two cells that are duplicates ... make up our body are made and replaced. Meiosis results in cells with half the number of ...

  12. Commissioning Results Of Angle-Resolved Photoemission System At The Siam Photon Laboratory

    This report describes the first results obtained by the angle-resolved photoemission system at the Siam Photon Laboratory. Nickel single crystal with (111) surface was selected as the sample. Sample preparation methods as well as measurement procedures are described. The total energy resolution at photon energy of 35 eV was 370 MeV. Surface energy band structure of the nickel was obtained from angle-resolved photoemission spectra along two lines of symmetry: τto Τto Κand τto ΣtoΜ. The experimental energy band structure is qualitatively agreed with a theoretical calculation

  13. Complexation of transuranic ions by humic substances: Application of laboratory results to the natural system

    Environmental investigations show transuranic ions sorb to humic substances. The resulting species are often mobile and are expected to be important vectors in the migration of transuranic ions in natural systems. However, these environmental studies yield no quantitative data useful for modeling. Laboratory complexation experiments with transuranic ions and humic substances generate thermodynamic data required for complexation modeling. The data presented in this work are based on the metal ion charge neutralization model, which is briefly described. When a consistent complexation model is used, similar results are obtained from different experimental conditions, techniques, and laboratories. Trivalent transuranic ions (Cm(III), Am(III)) have been extensively studied with respect to pH, ionic strength, origin of humic acid, and mixed species formation. The complexation of Np(V) has been examined over a large pH and metal ion concentration range with different humic acids. Some data does exist on the complexation ion concentration range with different humic acids. Some data does exist on the complexation of plutonium with humic acid, however further work is needed. Calculations on the Gorleben aquifer system using the thermodynamic data are presented. Critical information lacking from the thermodynamic database is identified. 55 refs., 2 figs., 3 tabs

  14. Initial experimental results from the Laboratory Biosphere closed ecological system facility

    Alling, A.; Allen, J.; Dempster, W.; Nelson, M.; Silverstone, S.; van Thillo, M.

    Results from the closure and initial closed ecological system research in the "Laboratory Biosphere" facility in Santa Fe, New Mexico (USA) will be presented. The facility was initially sealed in April 2002; and the first crop experiments with soybeans commenced in May 2002. The Laboratory Biosphere was created by the team which invented, built and operated Biosphere 2 during its years of closed ecological system functioning (1991-94) and is a testbed to build upon the lessons learned. It is an opportunity to continue experiments with a sustainable soil based agriculture system unlike most bioregenerative systems which use hydroponic systems dependent on a supply of nutrient solution. Because of the small volume of the system (34-45 m3), developing mechanisms to keep parameters like carbon dioxide within acceptable limits will be critical. Recycle of nutrients within the system to maintain soil fertility; and the ability of the inherent complex ecology of soils and a soil bed reactor to handle trace gas buildups are primary research goals. Other research goals are determination of short and long-term exchanges between soil, plants and atmosphere, especially for carbon dioxide, oxygen, nitrogen, NOX, and methane, impact of cultivation (tillage) on soil/atmospheric exchanges., investigation and development of strategies to return nutrients to the soil to maintain fertility, e.g. shredding biomass vs. composting, impact on soil chemistry of returning leachate water to the soil as irrigation water. The microbiological status of soils prior to experiments and over time will allow measurement of changes in microbial diversity and the determination of the role of soil microbes in biogeochemical cycles. Integration of automated sensor and control in the system with real-time modeling has importance for operation, research and educational outreach programs. The Laboratory Biosphere is intended to test and develop a "cybersphere" (network of shared intelligence) that may be

  15. Testbeam and laboratory test results of irradiated 3D CMS pixel detectors

    Bubna, Mayur [Purdue University, Department of Physics, West Lafayette, IN 47907-1396 (United States); Purdue University, School of Electrical and Computer Engineering, West Lafayette, IN 47907-1396 (United States); Alagoz, Enver, E-mail: enver.alagoz@cern.ch [Purdue University, Department of Physics, West Lafayette, IN 47907-1396 (United States); Cervantes, Mayra; Krzywda, Alex; Arndt, Kirk [Purdue University, Department of Physics, West Lafayette, IN 47907-1396 (United States); Obertino, Margherita; Solano, Ada [Istituto Nazionale di Fisica Nucleare, Sezione di Torino, 10125 Torino (Italy); Dalla Betta, Gian-Franco [INFN Padova (Gruppo Collegato di Trento) (Italy); Dipartimento di Ingegneria e Scienzadella Informazione, Universitá di Trento, I-38123 Povo di Trento (Italy); Menace, Dario; Moroni, Luigi [Istituto Nazionale di Fisica Nucleare, Sezione di Milano Bicocca (Italy); Universitá degli Studi di Milano Bicocca, 20126 Milano (Italy); Uplegger, Lorenzo; Rivera, Ryan [Fermi National Accelerator Laboratory, Batavia, IL 60510-0500 (United States); Osipenkov, Ilya [Texas A and M University, Department of Physics, College Station, TX 77843-4242 (United States); Andresen, Jeff [Fermi National Accelerator Laboratory, Batavia, IL 60510-0500 (United States); Bolla, Gino; Bortoletto, Daniela [Purdue University, Department of Physics, West Lafayette, IN 47907-1396 (United States); Boscardin, Maurizio [Centro per i Materiali e i Microsistemi Fondazione Bruno Kessler (FBK), Trento, I-38123 Povo di Trento (Italy); Marie Brom, Jean [Strasbourg IPHC, Institut Pluriedisciplinaire Hubert Curien, F-67037 Strasbourg Cedex (France); Brosius, Richard [State University of New York at Buffalo (SUNY), Department of Physics, Buffalo, NY 14260-1500 (United States); Chramowicz, John [Fermi National Accelerator Laboratory, Batavia, IL 60510-0500 (United States); and others

    2013-12-21

    The CMS silicon pixel detector is the tracking device closest to the LHC p–p collisions, which precisely reconstructs the charged particle trajectories. The planar technology used in the current innermost layer of the pixel detector will reach the design limit for radiation hardness at the end of Phase I upgrade and will need to be replaced before the Phase II upgrade in 2020. Due to its unprecedented performance in harsh radiation environments, 3D silicon technology is under consideration as a possible replacement of planar technology for the High Luminosity-LHC or HL-LHC. 3D silicon detectors are fabricated by the Deep Reactive-Ion-Etching (DRIE) technique which allows p- and n-type electrodes to be processed through the silicon substrate as opposed to being implanted through the silicon surface. The 3D CMS pixel devices presented in this paper were processed at FBK. They were bump bonded to the current CMS pixel readout chip, tested in the laboratory, and testbeams carried out at FNAL with the proton beam of 120 GeV/c. In this paper we present the laboratory and beam test results for the irradiated 3D CMS pixel devices. -- Highlights: •Pre-irradiation and post-irradiation electrical properties of 3D sensors and 3D diodes from various FBK production batches were measured and analyzed. •I–T measurements of gamma irradiated diodes were analyzed to understand leakage current generation mechanism in 3D diodes. •Laboratory measurements: signal to noise ratio and charge collection efficiency of 3D sensors before and after irradiation. •Testbeam measurements: pre- and post-irradiation pixel cell efficiency and position resolution of 3D sensors.

  16. Results of the Dyslipidemia International Study (DYSIS-Middle East: clinical perspective on the prevalence and characteristics of lipid abnormalities in the setting of chronic statin treatment.

    Saud N Al Sifri

    Full Text Available BACKGROUND: Therapeutic intervention with low-density lipoprotein cholesterol-lowering agents known as statins has been demonstrated to reduce cardiovascular risk. However, many patients on statin treatment have persistent dyslipidemia and remain at a high risk of cardiovascular disease. Therefore, the objective of this study was to assess the frequency of lipid abnormalities in patients receiving chronic statin treatment. METHODS: As part of an international, cross-sectional, observational study, DYSIS-Middle East enrolled 2,182 patients in the United Arab Emirates (UAE, Saudi Arabia, Lebanon and Jordan. All patients were over 45 years of age and had been on statin treatment for at least three months. Data on demographics, lipid parameters and cardiovascular risk profile were recorded. Cardiovascular risk was defined according the guidelines of the European Society of Cardiology. RESULTS: The majority of patients (82.6% were classified as being at very high risk of cardiovascular events, and 61.8% of all patients did not attain LDL-C target levels. Low high-density lipoprotein cholesterol levels and elevated triglyceride levels were noted in 55.5% and 48.5% of patients, respectively. Multivariate logistical regression modeling indicated that factors independently associated with LDL-C levels not being at goal were lifestyle choices, diabetes mellitus, ischemic heart disease, and blood pressure ≥ 140/90 mmHg. CONCLUSIONS: Almost two-thirds of statin-treated patients in the United Arab Emirates, Saudi Arabia, Lebanon and Jordan had inadequately controlled lipid levels. More comprehensive surveillance, awareness and treatment regimens, as well as modification of lifestyle choices, is necessary to halt the rise in cardiovascular disease-related mortality.

  17. First results of the IGEX dark matter experiment at the Canfranc Underground Laboratory

    The enriched 76Ge double-beta decay detectors from the International Germanium EXperiment (IGEX), operating in the Canfranc Underground Laboratory with an overbuden of 2450 m.w.e., were recently upgraded to use them also in a search for WIMPs. This paper presents a description of the experiment and the data analysis as well as a new exclusion plot, σ(m), derived from the IGEX data for WIMP-nucleon spin-independent interaction. To obtain this result, 30 days of data from one 2-kg IGEX detector, with an energy threshold Ethr ∼ 4 keV, have been considered. These results improve the exclusion limits derived from other conventional ionization germanium experiments in the ∼ 50 GeV DAMA region

  18. Intermediate-Scale Laboratory Experiments of Subsurface Flow and Transport Resulting from Tank Leaks

    Oostrom, Martinus; Wietsma, Thomas W.

    2014-09-30

    Washington River Protection Solutions contracted with Pacific Northwest National Laboratory to conduct laboratory experiments and supporting numerical simulations to improve the understanding of water flow and contaminant transport in the subsurface between waste tanks and ancillary facilities at Waste Management Area C. The work scope included two separate sets of experiments: •Small flow cell experiments to investigate the occurrence of potential unstable fingering resulting from leaks and the limitations of the STOMP (Subsurface Transport Over Multiple Phases) simulator to predict flow patterns and solute transport behavior under these conditions. Unstable infiltration may, under certain conditions, create vertically elongated fingers potentially transporting contaminants rapidly through the unsaturated zone to groundwater. The types of leak that may create deeply penetrating fingers include slow release, long duration leaks in relatively permeable porous media. Such leaks may have occurred below waste tanks at the Hanford Site. •Large flow experiments to investigate the behavior of two types of tank leaks in a simple layered system mimicking the Waste Management Area C. The investigated leaks include a relatively large leak with a short duration from a tank and a long duration leak with a relatively small leakage rate from a cascade line.

  19. Simulation and laboratory test results of 3D CMS pixel detectors for HL-LHC

    Alagoz, E.; Bubna, M.; Krzywda, A.; Dalla Betta, G. F.; Povoli, M.; Obertino, M. M.; Solano, A.; Vilela Pereira, A.; Arndt, K.; Bolla, G.; Bortoletto, D.; Boscardin, M.; Kwan, S.; Rivera, R.; Shipsey, I.; Uplegger, L.

    2012-08-01

    The CMS pixel detector is the innermost tracking device at the LHC, reconstructing interaction vertices and charged particle trajectories. The current planar sensors located in the innermost layer of the pixel detector will be exposed to very high fluences which will degrade their performances. As a possible replacement for planar pixel sensors in the High Luminosity-LHC (HL-LHC), 3D silicon technology is under consideration due to its expected good performance in harsh radiation environments. Studies are also in progress for using 3D silicon pixel detectors in near-beam proton spectrometers at the LHC. Deep Reactive Ion Etching (DRIE) plays a key role in fabricating 3D silicon detectors in which readout and ohmic electrodes are processed through the silicon substrate instead of being implanted on the silicon surface. 3D pixel devices considered in this study were processed at FBK (Trento, Italy), bump bonded to the CMS pixel readout chip, and characterized in the laboratory. Numerical simulations were also carried out. We report on selected results from laboratory measurements and TCAD simulations.

  20. Testbeam and laboratory test results of irradiated 3D CMS pixel detectors

    Bubna, Mayur; Alagoz, Enver; Cervantes, Mayra; Krzywda, Alex; Arndt, Kirk; Obertino, Margherita; Solano, Ada; Dalla Betta, Gian-Franco; Menace, Dario; Moroni, Luigi; Uplegger, Lorenzo; Rivera, Ryan; Osipenkov, Ilya; Andresen, Jeff; Bolla, Gino; Bortoletto, Daniela; Boscardin, Maurizio; Marie Brom, Jean; Brosius, Richard; Chramowicz, John; Cumalat, John; Dinardo, Mauro; Dini, Paolo; Jensen, Frank; Kumar, Ashish; Kwan, Simon; Lei, C. M.; Povoli, Marco; Prosser, Alan; Ngadiuba, Jennifer; Perera, Lalith; Shipsey, Ian; Tan, Ping; Tentindo, Silvia; Terzo, Stefano; Tran, Nhan; Wagner, Stephen R.

    2013-12-01

    The CMS silicon pixel detector is the tracking device closest to the LHC p-p collisions, which precisely reconstructs the charged particle trajectories. The planar technology used in the current innermost layer of the pixel detector will reach the design limit for radiation hardness at the end of Phase I upgrade and will need to be replaced before the Phase II upgrade in 2020. Due to its unprecedented performance in harsh radiation environments, 3D silicon technology is under consideration as a possible replacement of planar technology for the High Luminosity-LHC or HL-LHC. 3D silicon detectors are fabricated by the Deep Reactive-Ion-Etching (DRIE) technique which allows p- and n-type electrodes to be processed through the silicon substrate as opposed to being implanted through the silicon surface. The 3D CMS pixel devices presented in this paper were processed at FBK. They were bump bonded to the current CMS pixel readout chip, tested in the laboratory, and testbeams carried out at FNAL with the proton beam of 120 GeV/c. In this paper we present the laboratory and beam test results for the irradiated 3D CMS pixel devices.

  1. Laboratory results of stress corrosion cracking of steam generator tubes in a complex environment - An update

    Horner, Olivier; Pavageau, Ellen-Mary; Vaillant, Francois [EDF R and D, Materials and Mechanics of Components Department, 77818 Moret-sur-Loing (France); Bouvier, Odile de [EDF Nuclear Engineering Division, Centre d' Expertise et d' Inspection dans les Domaines de la Realisation et de l' Exploitation, 93206 Saint Denis (France)

    2004-07-01

    Stress corrosion cracking occurs in the flow-restricted areas on the secondary side of steam generator tubes of Pressured Water Reactors (PWR), where water pollutants are likely to concentrate. Chemical analyses carried out during the shutdowns gave some insight into the chemical composition of these areas, which has evolved during these last years (i.e. less sodium as pollutants). It has been modeled in laboratory by tests in two different typical environments: the sodium hydroxide and the sulfate environments. These models satisfactorily describe the secondary side corrosion of steam generator tubes for old plant units. Furthermore, a third typical environment - the complex environment - which corresponds to an All Volatile Treatment (AVT) environment containing alumina, silica, phosphate and acetic acid has been recently studied. This particular environment satisfactorily reproduces the composition of the deposits observed on the surface of the steam generator tubes as well as the degradation of the tubes. A review of the recent laboratory results obtained by considering the complex environment are presented here. Several tests have been carried out in order to study initiation and propagation of secondary side corrosion cracking for some selected materials in such an environment. 600 Thermally Treated (TT) alloy reveals to be less sensitive to secondary side corrosion cracking than 600 Mill Annealed (MA) alloy. Finally, the influence of some related factors like stress, temperature and environmental factors are discussed. (authors)

  2. The role of laboratory animals in studying bone cancer resulting from skeletally deposited radionuclides

    There is a continuing need to determine and understand the long-term health risks of internally deposited radionuclides in persons exposed medically or occupationally, or from radionuclides in the environment. A full understanding of these health risks, particularly for exposures involving low doses and dose rates, requires in-depth knowledge of both the dosimetry of a given exposure and the resulting long-term biological effects. Human data on 224Ra and 226,228Ra and their decay products are our primary sources of knowledge on the health risks of chronic alpha irradiation of the skeleton and serve as essential segments of our radiation protection practices for internally deposited radionuclides. However, we cannot obtain all of the needed information from these studies. This paper examines the role of laboratory animal studies in complementing and extending the knowledge of radiation-induced bone cancer obtained from studies of humans exposed to 224Ra or 226,228Ra

  3. Overview of laboratory testing results for an imaging Fabry-Perot interferometer

    Larar, Allen M.; Cook, William B.; Flood, Michael A.; Campbell, Joel F.; Boyer, Charles M.; Remus, Rubin G.; Burcher, Ernest E.; Puschell, Jeffery J.

    2007-10-01

    An airborne imaging Fabry-Perot Interferometer (FPI) system was developed within NASA's Instrument Incubator Program (IIP) to mitigate risk associated with implementation of such a device in future space-based atmospheric remote sensing missions. This system is focused on observing tropospheric ozone through measuring a narrow spectral interval within the strong 9.6 micron infrared ozone band at high spectral resolution, while the concept and technology also have applicability toward measurement of other trace species and other applications. The latest results from laboratory testing and characterization of enabling subsystems and the overall instrument system will be reported, with an emphasis placed on testing performed to evaluate system-level radiometric, spatial, and spectral measurement fidelity.

  4. Formation of chloroform in spruce forest soil - results from laboratory incubation studies

    Haselmann, K.F.; Laturnus, F.; Svensmark, B.; Grøn, C.

    2000-01-01

    The release of chloroform, 1,1,1-trichloroethane, tetrachloromethane, trichloroethene and tetrachloroethene from an organic rich spruce forest soil was studied in laboratory incubation experiments by dynamic headspace analysis, thermodesorption and gas chromatography. Performance parameters are...... presented for the dynamic headspace system. For spruce forest soil, the results showed a significant increase in chloroform concentration in the headspace under aerobic conditions over a period of seven days, whereas the concentration of the other compounds remained fairly constant. A biogenic formation of...... chloroform is suggested, whereas for the other compounds anthropogenic sources are assumed. The addition of trichloroacetic acid to the soil increased the release of chloroform from the soil. It is, therefore, suggested that trichloroacetic acid also contributed to the formation of chloroform. Under the...

  5. Area Monitoring Dosimeter Program for the Pacific Northwest National Laboratory: Results for CY 2005

    Bivins, Steven R.; Stoetzel, Gregory A.

    2006-06-21

    Pacific Northwest National Laboratory (PNNL) established an area monitoring dosimeter program in accordance with Article 514 of the Department of Energy (DOE) Radiological Control Manual (RCM) in January 1993. This program is to minimize the number of areas requiring issuance of personnel dosimeters and to demonstrate that doses outside Radiological Buffer Areas are negligible. In accordance with 10 CFR Part 835.402 (a)(1)-(4) and Article 511.1 of the PNNL Radiological Control Program Description, personnel dosimetry shall be provided to (1) radiological workers who are likely to receive at least 100 mrem annually, and (2) declared pregnant workers, minors, and members of the public who are likely to receive at least 50 mrem annually. Program results for calendar years 1993-2005 confirm that personnel dosimetry is not needed for individuals located in areas monitored by the program

  6. Area Monitoring Dosimeter Program for the Pacific Northwest National Laboratory: Results for CY 2006

    Bivins, Steven R.; Stoetzel, Gregory A.

    2007-07-19

    Pacific Northwest National Laboratory (PNNL) established an area monitoring dosimeter program in accordance with Article 514 of the Department of Energy (DOE) Radiological Control Manual (RCM) in January 1993. This program is to minimize the number of areas requiring issuance of personnel dosimeters and to demonstrate that doses outside Radiological Buffer Areas are negligible. In accordance with 10 CFR Part 835.402 (a)(1)-(4) and Article 511.1 of the PNNL Radiological Control Program Description, personnel dosimetry shall be provided to 1) radiological workers who are likely to receive at least 100 mrem annually, and 2) declared pregnant workers, minors, and members of the public who are likely to receive at least 50 mrem annually. Program results for calendar years 1993-2005 confirm that personnel dosimetry is not needed for individuals located in areas monitored by the program.

  7. Laboratory and test beam results from a large-area silicon drift detector

    A very large-area (6.75x8 cm2) silicon drift detector with integrated high-voltage divider has been designed, produced and fully characterised in the laboratory by means of ad hoc designed MOS injection electrodes. The detector is of the 'butterfly' type, the sensitive area being subdivided into two regions with a maximum drift length of 3.3 cm. The device was also tested in a pion beam (at the CERN PS) tagged by means of a microstrip detector telescope. Bipolar VLSI front-end cells featuring a noise of 250 e- rms at 0 pF with a slope of 40 e-/pF have been used to read out the signals. The detector showed an excellent stability and featured the expected characteristics. Some preliminary results will be presented.

  8. Laboratory results from suction controlled tests on a water unsaturated bentonite

    The buffer material used in the KBS-3 concept embedding the waste canister in the deep repository for nuclear waste is a highly compacted bentonite clay. The saturated homogenous bentonite is expected to fully act as a buffer material. During the wetting of the unsaturated bentonite swelling pressure and decrease in suction will develop. To increase the knowledge of the hydro-mechanical behaviour of the unsaturated swelling bentonite a laboratory program was carried through. The water saturation process is often modelled as driven by a gradient in suction (or negative pore water pressure) and impact of factors as void ratio, degree of saturation and external load on suction was therefore an important part of the investigation. The focus of the laboratory program was to investigate the influence of confinement on the water retention properties, the development of swelling pressure during decrease in suction and the effect of external load and swelling pressure on suction. The test types chosen for the majority of the tests were increase in water content under free swelling or under constant volume conditions and measurement of swelling pressure. The water content was controlled by keeping suction constant by an imposed relative humidity technique. In addition tests with constant water content and externally applied load have been performed. In those tests relative humidity was measured. The investigated clay was MX-80, which is a commercial bentonite from American Colloid Co. with a liquid limit WL of about 500%. The impact of confinement and initial water content on water uptake, suction and development of swelling pressure are shown. The results also include experiences regarding the testing techniques. Measured swelling pressure against time is shown from constant volume tests with suction control. Only selected results from one of the test series are shown. The figure shows that swelling pressure develops during hygroscopic water uptake. It also shows that the

  9. Laboratory corrosion tests on candidate high-level waste container materials: Results from the Belgian programme

    The Belgian SAFIR-2 concept foresees the geological disposal of conditioned high-level radioactive waste in stainless steel containers and overpacks placed in a concrete gallery backfilled with Boom clay or a bentonite-type backfill. In addition to earlier in situ experiments, we used a laboratory approach to investigate the corrosion properties of selected stainless steels in Boom clay and bentonite environments. In the SAFIR-2 concept, AISI 316L hMo is the main candidate overpack material. As an alternative, we also investigated the higher alloyed stainless steel UHB 904L. Our study focused on localised corrosion and in particular pitting. We used cyclic potentiodynamic polarisation measurements to determine the pit nucleation potential ENP and the protection potential EPP. The evolution of the corrosion potential with time was determined by monitoring the open circuit potential in synthetic clay-water over extended periods. In this paper we present and discuss some results from our laboratory programme, focusing on long-term interactions between the stainless steel overpack and the backfill materials. We describe in particular the influence of chloride and thio-sulphate ions on the pitting corrosion behaviour. The results show that, under geochemical conditions typical for geological disposal, i.e. [Cl-] ∼ 30 mg/L for a Boom clay backfill and [Cl-] ∼ 90 mg/L for a bentonite backfill, neither AISI 316L hMo nor UHB 904L is expected to present pitting problems. An important factor in the long-term prediction of the corrosion behaviour however, is the robustness of the model for the evolution of the geochemistry of the backfill. Indeed, at chloride levels higher than 1000 mg/L, we predict pitting corrosion for AISI 316L hMo. (authors)

  10. Human COL2A1-directed SV40 T antigen expression in transgenic and chimeric mice results in abnormal skeletal development

    1995-01-01

    The ability of SV40 T antigen to cause abnormalities in cartilage development in transgenic mice and chimeras has been tested. The cis- regulatory elements of the COL2A1 gene were used to target expression of SV40 T antigen to differentiating chondrocytes in transgenic mice and chimeras derived from embryonal stem (ES) cells bearing the same transgene. The major phenotypic consequences of transgenic (pAL21) expression are malformed skeleton, disproportionate dwarfism, and perinatal/neonatal d...

  11. Evaluation of the 10th External Quality Assessment Scheme results in clinical microbiology laboratories in Tehran and districts.

    Abbassi, M; Rahbar, M; Hekmat Yazdi, S; Rashed Marandi, F; Sabourian, R; Saremi, M

    2006-01-01

    We evaluated the performance of microbiology laboratories in the 10th run of the external quality assessment scheme (EQAS) in Tehran and districts. Each laboratory was sent 2 species of bacteria for identification. Of the 487 laboratories that participated, 437 returned their findings. While 77.0% and 69.9% correctly identified Staphylococcus saprophyticus and Citrobacter freundii respectively, only 29.8% correctly identified Acinetobacter baumanii, 25.3% identified Enterococcus faecalis and 35.6% identified Enterobacter agglomerans. However 78.7% and 79.5% of the laboratories reported correct -results for susceptibility testing for S. saprophyticus and C. freundii respectively. PMID:17037699

  12. Area monitoring dosimeter program for the Pacific Northwest National Laboratory: Results for CY 1997

    In January 1993, Pacific Northwest National Laboratory (PNNL) established an area monitoring dosimeter program in accordance with Article 514 of the US Department of Energy (DOE) Radiological Control Manual (RCM). The purpose of the program was to minimize the number of areas requiring issuance of personnel dosimeters and to demonstrate that doses outside Radiological Buffer Areas are negligible. In accordance with 10 CFR Part 835.402 (a) (1)--(3) and Article 511.1 of the RCM, personnel dosimetry shall be provided to (1) radiological workers who are likely to receive at least 100 mrem annually, and (2) declared pregnant workers, minors, and members of the public who are likely to receive at least 50 mrem annually. Program results for calendar years (CY) 1993--1996 confirmed that personnel dosimetry was not needed for individuals located in areas monitored by the program. A total of 93 area thermoluminescent dosimeters (TLDs) were placed in PNNL facilities during CY 1997. The TLDs were exchanged and analyzed quarterly. All routine area monitoring TLD results were less than 50 mrem annually after correcting for worker occupancy. The results support the conclusions that personnel dosimeters are not necessary for staff, declared pregnant workers, minors, or members of the public in these monitored areas

  13. Standardisation of environmental enrichment for laboratory mice and rats: Utilisation, practicality and variation in experimental results

    Baumans, V.; Loo, P.L.P. van; Pham, T.M.

    2010-01-01

    Rats and mice are the most commonly used species as laboratory animal models of diseases in biomedical research. Environmental factors such as cage size, number of cage mates and cage structure such as environmental enrichment can affect the physiology and behavioural development of laboratory anima

  14. Heavy metal contaminant remediation study of western Xiamen Bay sediment, China: laboratory bench scale testing results.

    Zhang, Luoping; Feng, Huan; Li, Xiaoxia; Ye, Xin; Jing, Youhai; Ouyang, Tong; Yu, Xingtian; Liang, Rongyuan; Chen, Weiqi

    2009-12-15

    A surface sediment sample (decontamination study. A series of laboratory-based experiments under various conditions were performed using chemical complexation reagents (e.g., H2C2O4, EDTA-2Na, etc.) and their combination in order to provide information for sediment remediation technology development. In this study, the results suggest that aeration and agitation of the sediment samples in distilled-deionized water (DDW) have either no or weak (metal removal, whereas agitation, aeration and rotation of the samples in chemical complexation solutions yield much better metal removal efficiency (up to 90%). A low pH condition (e.g., pHmetal removal efficiency. The experimental results suggest that 0.20 M (NH4)2C2O4+0.025 M EDTA combination with solid:liquid ratio=1:50 and 0.50 M ammonium acetate (NH4Ac)+0.025 M EDTA combination with solid:liquid ratio=1:50 are the most effective methods for metal removal from the contaminated sediments. This research provides additional useful information for sediment metal remediation technology development. PMID:19631459

  15. Instability of surface lenticular vortices: results from laboratory experiments and numerical simulations

    Lahaye, Noé; Paci, Alexandre; Smith, Stefan Llewellyn

    2016-04-01

    We examine the instability of lenticular vortices -- or lenses -- in a stratified rotating fluid. The simplest configuration is one in which the lenses overlay a deep layer and have a free surface, and this can be studied using a two-layer rotating shallow water model. We report results from laboratory experiments and high-resolution direct numerical simulations of the destabilization of vortices with constant potential vorticity, and compare these to a linear stability analysis. The stability properties of the system are governed by two parameters: the typical upper-layer potential vorticity and the size (depth) of the vortex. Good agreement is found between analytical, numerical and experimental results for the growth rate and wavenumber of the instability. The nonlinear saturation of the instability is associated with conversion from potential to kinetic energy and weak emission of gravity waves, giving rise to the formation of coherent vortex multipoles with trapped waves. The impact of flow in the lower layer is examined. In particular, it is shown that the growth rate can be strongly affected and the instability can be suppressed for certain types of weak co-rotating flow.

  16. Overview, goals, and preliminary results of E910 laboratory directed research and development at Lawrence Livermore National Laboratory

    Soltz, R.A.; E910 Collaboration

    1997-01-24

    E910 is a large acceptance proton-nucleus experiment at the BNL AGS. The experiment completed its first run in the Spring of 1996, collecting more than 20 million pA events, using Be, Cu, Au, and U targets. We present preliminary results for momentum conservation, slow proton distributions, and dN/dy for negative tracks. 16 refs., 5 figs.

  17. Electromagnetic (EM) earthquake precursor transmission and detection regarding experimental field and laboratory results.

    Jones, Kenneth B., II; Saxton, Patrick

    2016-04-01

    Aside from understanding the animal kingdom reacting to a per-earthquake signal, a transmission source is apparent. The focus of this investigation is an electromagnetic emission approach and detection capable of becoming both practical and reliable to other plausible earthquake precursors. To better determine this method, several prototype magnetometers were devised and built with each successive version improving upon the next. Two twin (prototype #2) antennae were deployed to field settings outside the NE Texas town of Timpson, TX back in February, 2013 and very recent laboratory tests using the most refined (prototype #4) experimental antenna for detecting unconfined, granitic block fracturing. Field testing encompassed the small NE Texas town of Timpson, TX, which endured an earthquake phenomenon (May, 2012 - September, 2013). A rare sequence of events was strictly attributed to hydraulic fracturing activity in the immediate area all for hydrocarbon capture; thus, a chance to detect and record man-made earthquake activity. By swiveling two directional antennae at three locations, one mobile, the antennae could 'zero' in on a signal source until its pattern was well established and mapped, accordingly. Three signals were detected, two strong and one moderately strong, each with epicenter implications several kilometers from known seismological sites. Six months later, two M4s and a M2.4 earthquake hit over the 2013 Labor Day weekend. Hydraulic pump pressure increased deep Earth pore pressure, reduced friction, and displaced opposing tectonic stresses causing rock to fracture. This was the last earthquake sequence in the Timpson area, due to personal involvement and area citizens in contact with their state representatives. Well and drilling operations have since moved 40-50 miles SE of Timpson, TX and rare earthquake activity has now occurred there. Laboratory testing was next performed using cored granitic blocks and the latest, improved antenna with an

  18. The Abnormal Choroidal Vessels in Aged Patients

    Shizhou Huang; Feng Wen; Dezheng Wu; Guangwei Luo; Caijiao Liu

    2002-01-01

    Background: To show the abnormal choroidal vessels in aged patients with indocyanine-green angiography (ICGA).Methods: ICGA was performed in 350 patients with TOPCON TRC-50IA fundus camera.The images were recorded and retrospectively reviewed.Results: Five aged patients out of 350 cases were found to have abnormal choroidalvessels. The incidence was 1.43%. The abnormal choroidal vessels showed round- shapet,focal enlargement, abnormal shape and entrance, satellite appearance, and vascularloops. These might be due to congenital abnormality of choroid.Conclusion: ICGA could be used to observe the abnormal choroidal vessels.

  19. Mizunami underground research laboratory project. Results from 1996-1999 period

    Tono Geoscience Center (TGC), Japan Nuclear Cycle Development Institute (JNC) has been conducting a wide range of geoscientific research in order to build a firm scientific and technological basis for the research and development of geological disposal. One of the major components of the ongoing gescientific research programme is the Mizunami Underground Research Laboratory (MIU) project in the Tono region, central Japan. The R and D work of the MIU project has the following main goals: Develop comprehensive investigation techniques for the geological environment. Acquire data on the deep geological environment. Develop a range of engineering techniques for deep underground application. The development of the MIU will occur in three overlapping phases over a 20-year life cycle: Phase One: Surface-based Investigations, began in 1996; Phase Two: Construction and Phase Three: Operations, have not started. The MIU site has been investigated by geological, geophysical, hydrogeological, hydrochemical and rock mechanical surveys on the surface and in the boreholes. To date, ground geophysics and investigation in three 1,000m-deep boreholes have been carried out. The hydro monitoring equipment has set up. Based on the information, modelling work on the geological, hydrogeological and rock mechanical conditions at the MIU site has been conducted. The groundwater simulation has been carried out in order to confirm the usefulness of the hydrogeological modelling methodology. Technical knowledge and experience have been accumulated, which allow application of the methodologies and techniques to characterize the deep geological environment in crystalline rock. The results from these R and D activities were used as prime inputs for the H12 report that JNC submitted to the Japanese Government in 1999. Results from such R and D are also acknowledged by other geoscientific studies in general. JNC will synthesize the results from R and D activities to provide a scientific and

  20. Laboratory results gained from cold worked type 316Ti under simulated PWR primary environment

    Beginning in 2005, intergranular stress corrosion cracking (IGSCC) of barrel bolts made from cold worked type 316Ti (German Material No. 1.4571 K) was observed in several S/KWU type PWRs. This mechanism was so far less understood for PWR primary conditions. Therefore an extended joint research program was launched by AREVA GmbH and VGB e.V. to clarify the specific conditions which contributed to the observed findings on barrel bolts. In the frame of this research program beneath the evaluation of the operational experience also laboratory tests on the general cracking behavior of cold worked type 316Ti material, which followed the same production line as for barrel bolt manufacturing in the eighties, with different cold work levels covering up to 30 % were performed to determine whether there is a specific susceptibility of cold worked austenitic stainless steel specimens to suffer IGSCC under simulated PWR primary conditions. All these slow strain rate tests on tapered specimens and component specimens came to the results that first, much higher cold work levels than used for the existing barrel bolts are needed for IGSCC initiation. Secondly, additional high active plastic deformation is needed to generate and propagate intergranular cracking. And thirdly, all specimens finally showed ductile fracture at the applied strain rates. (authors)

  1. First Results from the XENON10 Dark Matter Experiment at the Gran Sasso National Laboratory

    Angle, J; Arneodo, F; Baudis, L; Bernstein, A; Bolozdynya, A; Brusov, P; Coelho, L C C; Dahl, C E; DeViveiros, L; Ferella, A D; Fernandes, L M P; Fiorucci, S; Gaitskell, R J; Giboni, K L; Gómez, R; Hasty, R; Kastens, L; Kwong, J; Lopes, J A M; Madden, N; Manalaysay, A; Manzur, A; McKinsey, D N; Monzani, M E; Ni, K; Oberlack, U; Orboeck, J; Plante, G; Santorelli, R; Santos, J M F dos; Shagin, P; Shutt, T; Sørensen, P; Schulte, S; Winant, C

    2007-01-01

    The XENON10 experiment at the Gran Sasso National Laboratory uses a 15 kg xenon dual phase time projection chamber (XeTPC) to search for dark matter weakly interacting massive particles (WIMPs). The detector measures simultaneously the scintillation and the ionization produced by radiation in pure liquid xenon, to discriminate signal from background down to 4.5 keV nuclear recoil energy. A blind analysis of 58.6 live days of data, acquired between October 6, 2006 and February 14, 2007, and using a fiducial mass of 5.4 kg, excludes previously unexplored parameter space, setting a new 90% C.L. upper limit for the WIMP-nucleon spin-independent cross-section of 8.8 x 10^{-44} cm^2 for a WIMP mass of 100 GeV/c^2, and 4.5 x 10^{-44} cm^2 for a WIMP mass of 30 GeV/c^2. This result further constrains predictions of supersymmetric models.

  2. Results of detailed characterization on CH-TRU mixed waste at Argonne National Laboratory-West

    Argonne National Laboratory-West and Lockheed Idaho Technologies Company have jointly participated in the Department of Energy's (DOE) Waste Isolation Pilot Plant Experimental Test Program since 1990. A new facility at Argonne was developed to improve the effectiveness and efficiency of contact-handled transuranic mixed waste characterization and to decrease the potential for facility contamination and personnel exposures. This new facility, the Waste Characterization Area, was approved for radioactive operations in March 1994. Between April and September 1994, forty-two waste drums containing mixed debris waste were characterized to support a study being performed to evaluate volatile organic compound concentrations in the void volume headspaces of waste drums. This paper presents the results of characterization performed at Argonne, emphasizing parameters important from a facility standpoint. Specifically, information is presented on drum surface dose rate, fissile content, number and type of gas samples, volatile organic compound concentration, and facility contamination levels. Actual values are compared to enveloping conditions assumed in the safety assessment for the characterization facility. Argonne-West is one of the first DOE sites to perform detailed waste characterization under the DOE's Transuranic Waste Characterization Program. The information presented herein could aid other storage and generator sites in developing characterization procedures and facilities

  3. Role of Organic Acids in Bioformation of Kaolinite: Results of Laboratory Experiments

    Bontognali, T. R. R.; Vasconcelos, C.; McKenzie, J. A.

    2012-04-01

    Clay minerals and other solid silica phases have a broad distribution in the geological record and greatly affect fundamental physicochemical properties of sedimentary rocks, including porosity. An increasing number of studies suggests that microbial activity and microbially produced organic acids might play an important role in authigenic clay mineral formation, at low temperatures and under neutral pH conditions. In particular, early laboratory experiments (Linares and Huertas, 1971) reported the precipitation of kaolinite in solutions of SiO2 and Al2O3 with different molar ratios SiO2/Al2O3, together with fulvic acid (a non-characterized mixture of many different acids containing carboxyl and phenolate groups) that was extracted from peat soil. Despite many attempts, these experiments could not be reproduced until recently. Fiore et al. (2011) hypothesized that the non-sterile fulvic acid might have contained microbes that participated in the formation of kaolinite. Using solutions saturated with Si and Al and containing oxalate and/or mixed microbial culture extracted from peat-moss soil, they performed incubation experiments, which produced kaolinite exclusively in solutions containing oxalate and microbes. We proposed to test the role of specific organic acids for kaolinite formation, conducting laboratory experiments at 25˚C, with solutions of sodium silicate, aluminum chloride and various organic compounds (i.e. EDTA, citric acid, succinic acid and oxalic acid). Specific organic acids may stabilize aluminum in octahedral coordination positions, which is crucial for the initial nucleation step. In our experiments, a poorly crystalline mineral that is possibly a kaolinite precursor formed exclusively in the presence of succinic acid. In experiments with other organic compounds, no incorporation of Al was observed, and amorphous silica was the only precipitated phase. In natural environments, succinic acid is produced by a large variety of microbes as an

  4. Ultrasonography of splenic abnormalities

    Ming-Jen Chen; Ming-Jer Huang; Wen-Hsiung Chang; Tsang-En Wang; Horng-Yuan Wang; Cheng-Hsin Chu; Shee-Chan Lin; Shou-Chuan Shih

    2005-01-01

    AIM: This report gives a comprehensive overview of ultrasonography of splenic abnormalities. Certain ultrasonic features are also discussed with pathologic correlation.METHODS: We review the typical ultrasonic characteristics of a wide range of splenic lesions, illustrating them with images obtained in our institution from 2000 to 2003.One hundred and three patients (47 men, 56 women),with a mean age of 54 years (range 9-92 years), were found to have an abnormal ultrasonic pattern of spleen.RESULTS: We describe the ultrasonic features of various splenic lesions such as accessory spleen, splenomegaly,cysts, cavernous hemangiomas, lymphomas, abscesses,metastatic tumors, splenic infarctions, hematomas, and rupture, based on traditional gray-scale and color Doppler sonography.CONCLUSION: Ultrasound is a widely available, noninvasive,and useful means of diagnosing splenic abnormalities. A combination of ultrasonic characteristics and clinical data may provide an accurate diagnosis. If the US appearance alone is not enough, US may also be used to guide biopsy of suspicious lesions.

  5. Holoprosencephaly due to numeric chromosome abnormalities.

    Solomon, Benjamin D; Rosenbaum, Kenneth N; Meck, Jeanne M; Muenke, Maximilian

    2010-02-15

    Holoprosencephaly (HPE) is the most common malformation of the human forebrain. When a clinician identifies a patient with HPE, a routine chromosome analysis is often the first genetic test sent for laboratory analysis in order to assess for a structural or numerical chromosome anomaly. An abnormality of chromosome number is overall the most frequently identified etiology in a patient with HPE. These abnormalities include trisomy 13, trisomy 18, and triploidy, though several others have been reported. Such chromosome number abnormalities are almost universally fatal early in gestation or in infancy. Clinical features of specific chromosome number abnormalities may be recognized by phenotypic manifestations in addition to the HPE. PMID:20104610

  6. Comparative assay of fluorescent antibody test results among twelve European National Reference Laboratories using various anti-rabies conjugates

    Robardet, E.; Andrieu, S.; Rasmussen, Thomas Bruun;

    2013-01-01

    Twelve National Reference Laboratories (NRLs) for rabies have undertaken a comparative assay to assess the comparison of fluorescent antibody test (FAT) results using five coded commercial anti-rabies conjugates (Biorad, Bioveta, Fujirebio, Millipore, and SIFIN conjugates). Homogenized positive...

  7. The study of the karyotype analysis results of 358 couples with abnormal pregnancy history%358例不良孕产史夫妇的染色体核型分析

    应香朵; 程启航

    2011-01-01

    目的 探讨具有不良孕产史夫妇的不良孕产史与染色体核型异常的关系.方法 采用外周血淋巴细胞培养技术,对358例具有不良孕产史的夫妇进行常规G显带核型分析.结果 358例不良孕产史夫妇中,共检出异常染色体核型39例,异常率为10.89%.其中随体变异13例,9号染色体臂间倒位9例,副缢痕的增长8例,相互易位7例,数目异常2例.染色体异常在男女发生的比例相当.结论 染色体核型异常是导致不良孕产史的重要原因之一,对不良孕产史夫妇双方进行细胞遗传学检查,提供优生咨询,再孕指导与监测,能够有效防止患儿出生,提高出生人口素质.%Objective: To investigate the relationship of abnormal pregnancy history and karyotype abnormality in 358 couples.Methods: The G - banding Patterns of the Chromosomes in 358 couples with abnormal pregnancy history were studied by Culture of Peripheral Blood Lymphocytes. Results: 39 karyotype abnormalities were detected in 358 couples, abnomal karyotype rate was 10. 89%.Among 39 cases, 13 had chromosome satellile varaiations, 9 had pericentric inversion 9, 8 had extended secondary constriction, 7 had balanced translocations, 2 had abnormal chromosome number. The abnomal karyotype rate was same between men and women.Conclusion: The karyotype abnormality is one of the important reasons of abnormal pregnancy. Cytogenetical study, eugenic advice,pregnancy guide and monitoring for couples with abnormal pregnancy history is useful to population quality.

  8. Electrochemical antimony removal from accumulator acid: Results from removal trials in laboratory cells

    Highlights: ► In non-divided cells, antimony did not deposit at cathode due to oxidation of Sb(III) at anode. ► Copper and graphite were found to be the most suitable electrode materials for antimony deposition. ► Sb species covering electrode lowers deposition efficiency with time. ► Thus, periodical renewal of cathode material is necessary. ► Calculated specific electroenergy consumption was relatively high. ► In contrast, absolute energy consumption was low due to small quantities of antimony removed. - Abstract: Regeneration of spent accumulator acid could be an alternative process for crystallization, neutralisation and disposal. Therefore, for the first time in a study of the possibilities of electrochemical removal of antimony and accumulator acid regeneration on a laboratory scale, two synthetic and several real systems containing sulfuric acid of concentrations ranging between 28% and 36%, and antimony species were tested. Discontinuous electrochemical reactors with anion exchange membranes were successfully used in these experiments, which were conducted at a temperature of 35 °C. Removal of antimony using cells that were not divided by a separator, however, was not possible. In selected experiments, by varying the electrode material, type of electrolyte, and cell current, the concentration of antimony could be reduced from the range of 5 ppm to 0.15 ppm. This resulted in current efficiencies between 0.00002% and 0.001%, and in specific electroenergy demands between 100 Wh L−1 and 2000 Wh L−1. In other experiments on substances with antimony contents up to 3500 mg L−1, the current efficiencies obtained were more than a thousandfold higher. In contrast to the formally high relative energy consumption parameters absolute demand parameters are relatively small and favour the electrochemical method in small scale application. Besides plate electrodes, 3D-cathodes were used. Copper- and graphite cathodes produced the best results.

  9. Thermo-Hydro-Mechanical properties of MX-80. Results from advanced laboratory tests

    Dueck, Ann; Nilsson, Ulf (Clay Technology AB, Lund (Sweden))

    2010-12-15

    General Highly compacted bentonite is proposed as the buffer material in the Swedish concept for disposal of nuclear waste. The saturated homogenized bentonite is expected to fully act as a buffer material between the waste canister and the surrounding bedrock. Material models describing the thermo-hydro-mechanical (THM) behaviour of the buffer material have been created with the purpose to simulate and predict the behaviour in a repository both before and after water saturation. The material models of water saturated and water unsaturated buffer material are complicated and contain a number of parameters that need to be determined. The present report is a compilation of results concerning thermo-hydro-mechanical laboratory tests on saturated and unsaturated buffer material. The main purpose of the report is to supply modelling groups with available results for improving models and determine parameters that can be used for the THM modelling of the behaviour of the buffer.Retention curves The relation between water content and relative humidity has been determined in a number of test series for some specific conditions, e.g. different initial water contents. Two methods have been used; the sorption balance method and a method with jars as desiccators. The majority of the results were derived from tests where RH was controlled and the response of the bentonite samples was measured. The results are given as water content versus relative humidity in diagrams and in tabular form. Volume change The volume change of water unsaturated bentonite specimens has been investigated by compression tests and swelling/shrinkage tests for some specific stress and moisture paths. The constant relative humidity was generated by the vapour equilibrium technique combined with an air circulation system. Measured stresses, deformation and relative humidity are presented versus time in diagrams and the final values at different stages are also presented in tabular form. Moisture transport

  10. Self-healing capacity of argillaceous rocks: review of laboratory results obtained from the Selfrac project

    As in all nuclear power generating countries, radioactive waste management is a crucial environmental issue. Underground storage in deep geological clay formations is one of the promising options to dispose such waste. An essential item for the safety of underground nuclear waste repositories is the evaluation of the excavated disturbed zone and the prediction of the evolution of mechanical and transport properties in this zone. The perturbation due to the excavation could e.g. induce an increase of the rock permeability due to diffuse and localised crack proliferation in the material. Fortunately, self-healing properties of clays can in turn progressively restore the initial conditions. One of the aims of the SELFRAC project is to understand and quantify the self-healing process that occurs in an excavated disturbed zone. A distinction must be made between self-healing and self-sealing. Self-healing is a spontaneous occurring process with many possible contributory underlying mechanisms that leads to a reduction in the impact of a fracture on both the hydraulic and the mechanical properties of the rock mass. Self-sealing can contribute to the partial self-healing of argillaceous rocks and is merely restricted to the restoration of the hydraulic properties of the perturbed medium. In this paper, we will use the generic term self-healing for both phenomena when no precision is available. This paper describes the CEN-SCK contribution to the results obtained and the observations made during the project. This contribution is materialized by laboratory tests that have been carried out on a soft (Boom Clay) and an indurated clay (Opalinus Clay) to determine their respective self-healing or self-sealing properties. In order to distinguish the respective influence of the mechanical and chemical components of the self-healing, two types of tests have been designed. (authors)

  11. Crystal habit modification of nickel-ferrite: development and results of initial laboratory testing

    This paper documents the results of a laboratory test program conducted to assess the feasibility of using a new type of additive in the primary coolant of pressurized water reactors (PWRs) or to boiling water reactor (BWR) coolant. These additives, known as crystal habit modifiers (CHMs), could potentially be used to control the crystal habits, or shapes, that comprise primary deposits and crud. Similar additives are used throughout the chemical process industry to produce products with desirable crystalline structure, morphology, density, particle size, or surface area. Based on the successes of CHM technologies in other industries, CHMs may have the potential to alleviate problems associated with deposits in nuclear plants including axial offset anomaly (AOA). By controlling the habit of deposit materials, it may be possible to retard deposit formation, produce deposits with desirable properties (e.g., high friability, low or high porosity), or promote a preferred chemical composition or deposit structure that is more amenable to removal. Desirable properties that could be selected for include enhanced boiling efficiency, reduced surface affinity for boron, and resistance to consolidation. The results of this project demonstrate that crystal habit modification of nickel ferrite, a typical primary side deposit species, can be achieved by the addition of both inorganic and organic chemical species (CHMs). The most significant habit modification of nickel ferrite was observed with the addition of metal species (e.g., Zn, Cr) due to their incorporation into the crystal lattice of the oxide. Lesser degrees of modification were achieved with organic additives such as acetate. Specific CHM candidates that may have a beneficial effect on PWR operation are identified in this paper. In addition, this paper summarizes the refinement of several methods for synthesizing nickel ferrites under hydrothermal conditions that may benefit those interested in studying crud and

  12. Evaluation of NAA laboratory results in inter-comparison on determination of trace elements in food and environmental samples

    Inter-comparison program is a good tool for improving quality and to enhance the accuracy and precision of the analytical techniques. By participating in this program, laboratories could demonstrate their capability and ensuring the quality of analysis results generated by analytical laboratories. The Neutron Activation Analysis (NAA) laboratory at National Nuclear Energy Agency of Indonesia (BATAN), Nuclear Technology Center for Materials and Radiometry-PTNBR laboratory participated in inter-comparison tests organized by NAA working group. Inter-comparison BATAN 2009 was the third inter-laboratory analysis test within that project. The participating laboratories were asked to analyze for trace elements using neutron activation analysis as the primary technique. Three materials were distributed to the participants representing foodstuff, and environmental material samples. Samples were irradiated in rabbit facility of G.A. Siwabessy reactor with neutron flux ~ 1013 n.cm-2.s-1, and counted with HPGe detector of gamma spectrometry. Several trace elements in these samples were detected. The accuracy and precision evaluation based on International Atomic Energy Agency (IAEA) criteria was applied. In this paper the PTNBR NAA laboratory results is evaluated. (author)

  13. Chemical characterization of clay SRM by X-ray fluorescence – results comparison from different laboratories

    Carlos Roberto Appoloni

    2009-03-01

    Full Text Available Two Energy Dispersive X-ray Fluorescence equipments have been compared in order to verify its performance for clay characterization and potential application to the study in archaeometric field and industry. Two clay standard reference materials (SRM, IPT-42 and IPT-51 and one IAEA intercomparison sample were analyzed by two different methodologies and equipments. Asentamiento Universitario Zapala laboratory has a Shimadzu EDX-800HS bench top equipment and 13 elements from S to Zr were quantified in the standards. Applied Nuclear Physics Laboratory has a portable EDXRF system. It was possible to quantify K, Ti and Fe and qualitatively to identify Mn, Rb, Zn and Zr.

  14. Urine - abnormal color

    ... medlineplus.gov/ency/article/003139.htm Urine - abnormal color To use the sharing features on this page, please enable JavaScript. The usual color of urine is straw-yellow. Abnormally colored urine ...

  15. Laboratory transport experiments with antibiotic sulfadiazine: Experimental results and parameter uncertainty analysis

    Sittig, S.; Vrugt, J. A.; Kasteel, R.; Groeneweg, J.; Vereecken, H.

    2011-12-01

    Persistent antibiotics in the soil potentially contaminate the groundwater and affect the quality of drinking water. To improve our understanding of antibiotic transport in soils, we performed laboratory transport experiments in soil columns under constant irrigation conditions with repeated applications of chloride and radio-labeled SDZ. The tracers were incorporated in the first centimeter, either with pig manure or with solution. Breakthrough curves and concentration profiles of the parent compound and the main transformation products were measured. The goal is to describe the observed nonlinear and kinetic transport behavior of SDZ. Our analysis starts with synthetic transport data for the given laboratory flow conditions for tracers which exhibit increasingly complex interactions with the solid phase. This first step is necessary to benchmark our inverse modeling approach for ideal situations. Then we analyze the transport behavior using the column experiments in the laboratory. Our analysis uses a Markov chain Monte Carlo sampler (Differential Evolution Adaptive Metropolis algorithm, DREAM) to efficiently search the parameter space of an advective-dispersion model. Sorption of the antibiotics to the soil was described using a model regarding reversible as well as irreversible sorption. This presentation will discuss our initial findings. We will present the data of our laboratory experiments along with an analysis of parameter uncertainty.

  16. Model-Based Reasoning in the Physics Laboratory: Framework and Initial Results

    Zwickl, Benjamin M.; Hu, Dehui; Finkelstein, Noah; Lewandowski, H. J.

    2015-01-01

    We review and extend existing frameworks on modeling to develop a new framework that describes model-based reasoning in introductory and upper-division physics laboratories. Constructing and using models are core scientific practices that have gained significant attention within K-12 and higher education. Although modeling is a broadly applicable…

  17. The formation, destruction and chemical influence of water ice: a review of recent laboratory results

    Oberg, Karin I.

    2015-08-01

    Water ice is ubiquitous in dense molecular clouds, the stellar nurseries of the Galaxy. Recent theoretical investigations (Cleeves et al. 2014) suggest that much of this pre-stellar ice survives disk formation and thus takes part in forming of planets and planetesimals. Interstellar and circumstellar ice abundances thus affect the compositions of planets. The presence of water ice is also important for the formation of other molecules on grains. Water is the most abundant ice constituent and therefore sets the ice diffusion environment, which regulates for example the organic photochemistry proposed to drive the complex chemical evolution during star formation.The processes that regulate the formation, destruction and chemical influence of water have all been explored in laboratory experiments. One of the most significant advances in recent years is the arrival of laboratory experiments on hydrogen additions to condensed O, O2 and O3 — the proposed main formation pathways of water ice. These experiments have revealed how the interplay between diffusion and reaction barriers together regulate the water formation chemistry as well as the chemistry of closely related carbon-bearing species such as CO2. A very different set of laboratory experiments have in the same time period constrained the efficiency of non-thermal water desorption, especially UV-induced ice photodesorption. Laboratory work on other non-thermal desorption pathways, e.g. chemical desorption, has also advanced, though more experiments are needed to quantify the importance of these desorption pathways relative to photodesorption. There are also an increasing number of experiments aimed at constraining the diffusion environment of water-dominated ices and its effects on the formation of organics when ice mixtures are exposed to UV photons or other kinds of energetic radiation.I will review the many significant laboratory water ice experiments that has been relaized in the past few years and how they

  18. LABORATORY TESTING RESULTS ANALYSIS OF GIARDIASIS PREVALENCE AMONG DIFFERENT POPULATION GROUPS IN THE NENETS AUTONOMOUS DISTRICT

    N. S. Bobyreva

    2015-01-01

    Full Text Available The Nenets Autonomous District (NAD refers to the territories of the Russia’s Far North. The country is the only region of Russia, where there are still no roads. The extreme weather conditions, as well as residential patterns in the NAD reduce the availability of specialized medical care, as indigenous people and other nationalities living in the district, which requires the use of health care management specific forms. The article presents data on giardiasis studies amongst different categories of the NAD population, obtained as a result of the population surveys in remote regions of the Russian Federation Arctic zone. Samples studied were serum and faecal emulsion. The study used the following laboratory methods: for serum — Giardia lamblia antibody screening method using ELISA kit, emulsion stool — native smear microscopy analysis, the method of enrichment using disposable concentrators «Parasep» immunological diagnostic methods based on the detection of specific lamblia antigen in faeces using ELISA kits. For statistics was used descriptive statistics analysis (mean values, the percentage error of the mean, the construction of the trend line with program SPSS 20.00, Excel 2010, the method of analysis of official statistical reporting hospitals survey on giardiasis, data of Rospotrebnadzor (Russian Sanitary service for NAD and data from own research from 2002 to 2013. Just in the process of research carried out research on the 10 356 giardiasis, registered diseases by 3470 cases of giardiasis, accounting for 99.14% of the total number of protozoonosises registered and 37.4% of all registered in the NAD parasitosis. The comparison was made among the population of the county towns, home to both the indigenous people, nomadic, and representatives of other ethnic groups, sedentary with urban population of the city of Naryan-Mar. The article analyzes the incidence rates for giardiasis according to district official statistical reporting

  19. Abnormal carbenes as ligands in transition metal chemistry: curiosities with exciting perspectives

    Albrecht, Martin

    2009-01-01

    This review compiles the advances achieved in our laboratories using abnormal and less heteroatom-stabilized carbenes as ligands for transition metal chemistry. Fundamental studies allowed the evaluation of the impact of this new class of ligands both electronically and sterically. Based on these results, initial catalytic applications have been devised in the area of H-H and C-H bond activation, demonstrating the potential of abnormal carbenes as unique ligands for transition metals.

  20. Cold Climate Foundation Retrofit Experimental Hygrothermal Performance. Cloquet Residential Research Facility Laboratory Results

    Goldberg, Louise F. [NorthernSTAR, St. Paul, MN (United States); Harmon, Anna C. [NorthernSTAR, St. Paul, MN (United States)

    2015-04-09

    This project was funded jointly by the National Renewable Energy Laboratory (NREL) and Oak Ridge National Laboratory (ORNL). ORNL focused on developing a full basement wall system experimental database to enable others to validate hygrothermal simulation codes. NREL focused on testing the moisture durability of practical basement wall interior insulation retrofit solutions for cold climates. The project has produced a physically credible and reliable long-term hygrothermal performance database for retrofit foundation wall insulation systems in zone 6 and 7 climates that are fully compliant with the performance criteria in the 2009 Minnesota Energy Code. These data currently span the period from November 10, 2012 through May 31, 2014 and are anticipated to be extended through November 2014. The experimental data were configured into a standard format that can be published online and that is compatible with standard commercially available spreadsheet and database software.

  1. Secondary EWSR1 gene abnormalities in SMARCB1-deficient tumors with 22q11-12 regional deletions: Potential pitfalls in interpreting EWSR1 FISH results.

    Huang, Shih-Chiang; Zhang, Lei; Sung, Yun-Shao; Chen, Chun-Liang; Kao, Yu-Chien; Agaram, Narasimhan P; Antonescu, Cristina R

    2016-10-01

    SMARCB1 inactivation occurs in a variety of tumors, being caused by various genetic mechanisms. Since SMARCB1 and EWSR1 genes are located close to each other on chromosome 22, larger SMARCB1 deletions may encompass the EWSR1 locus. Herein, we report four cases with SMARCB1-deletions showing concurrent EWSR1 gene abnormalities by FISH, which lead initially to misinterpretations as EWSR1-rearranged tumors. Our study group included various morphologies: a poorly differentiated chordoma, an extrarenal rhabdoid tumor, a myoepithelial carcinoma, and a proximal-type epithelioid sarcoma. All cases showed loss of SMARCB1 (INI1) by immunohistochemistry (IHC) and displayed characteristic histologic features for the diagnoses. The SMARCB1 FISH revealed homozygous or heterozygous deletions in three and one case, respectively. The co-hybridized EWSR1 probes demonstrated either unbalanced split signals or heterozygous deletion in two cases each. The former suggested bona fide rearrangement, while the latter resembled an unbalanced translocation. However, all the FISH patterns were quite complex and distinct from the simple and uniform split signals seen in typical EWSR1 rearrangements. We conclude that in the context of 22q11-12 regional alterations present in SMARCB1-deleted tumors, simultaneous EWSR1 involvement may be misinterpreted as equivalent to EWSR1 rearrangement. A detailed clinicopathologic correlation and supplementing the EWSR1 FISH assay with complementary methodology is mandatory for correct diagnosis. © 2016 Wiley Periodicals, Inc. PMID:27218413

  2. Results of Laboratory Scale Fracture Tests on Rock/Cement Interfaces

    Um, Wooyong; Jung, Hun Bok

    2012-06-01

    A number of pure cement and cement-basalt interface samples were subjected to a range of compressive loads to form internal fractures. X-ray microtomography was used to visualize the formation and growth of internal fractures in three dimensions as a function of compressive loads. This laboratory data will be incorporated into a geomechanics model to predict the risk of CO2 leakage through wellbores during geologic carbon storage.

  3. Systematic Differences in Test Results across Real vs. Virtual Shopper Laboratory Stores

    Desmet, Pierre; Traynor, John

    2010-01-01

    To limit the risk of failure in marketing initiatives while preserving confidentiality, businesses employ tests carried out in shopper laboratory stores. Compared with real market testing, real or virtual tests in such stores can reduce costs, and facilitate implementation and control of the environment. This study confirms that tested in ‘real’ or ‘virtual’ environments, product and brand image evaluations bear comparison. However, it reveals significant differences in behavioural indicators...

  4. Pavement polishing—Development of a dedicated laboratory test and its correlation with road results

    Do, Minh Tan; TANG, Zhen Zhong; Kane, Malal; De Larrard, François

    2007-01-01

    Skid-resistance of trafficked roads decreases due to polishing and can have a drastic consequence on the driver safety. There is a need to dispose of a laboratory test to forecast such variations on asphalt-mix specimens before the road construction. This paper is focused on the development of a polishing methodology using the so-called Wehner/Schulze machine. Three trafficked roads have been monitored since their construction to provide data on actual friction evolutions. Specimens are ta...

  5. Pavement polishing : Development of a dedicated laboratory test and its correlation with road results

    DO, MT; Tang, Z.; Kane, M.; DE LARRARD, F

    2007-01-01

    Skid-resistance of trafficked roads decreases due to polishing and can have a drastic consequence on the driver safety. There is a need to dispose of a laboratory test to forecast such variations on asphalt-mix specimens before the road construction. This paper is focused on the development of a polishing methodology using the so-called Wehner/Schulze machine. Three trafficked roads have been monitored since their construction to provide data on actual friction evolutions. Specimens are taken...

  6. Automated cognitive testing of monkeys in social groups yields results comparable to individual laboratory based testing

    Gazes, Regina Paxton; Brown, Emily Kathryn; Basile, Benjamin M.; Hampton, Robert R.

    2012-01-01

    Cognitive abilities likely evolved in response to specific environmental and social challenges and are therefore expected to be specialized for the life history of each species. Specialized cognitive abilities may be most readily engaged under conditions that approximate the natural environment of the species being studied. While naturalistic environments might therefore have advantages over laboratory settings for cognitive research, it is difficult to conduct certain types of cognitive test...

  7. Laboratory test for EPB tunnelling assessment:results of test campaign on two different granular soils

    Borio, Luca; Peila, Daniele

    2011-01-01

    Earth Pressure Balanced shields are currently the most utilized tunnelling machines throughout around the world. The possibility of using conditioning agents that change the mechanical and hydraulic behaviour of a soil, changing it into a plastic paste and thus permitting soil pressure applications at the tunnel face, is the key point to explain the increasing utilization of this technology. Despite its great importance, not much laboratory researches can be registered on soil conditioning, p...

  8. Factors controlling short-term soil microbial response after laboratory heating. Preliminary results

    Jiménez-Compán, Elizabeth; Jiménez-Morillo, Nicasio; Jordán, Antonio; Bárcenas-Moreno, Gema

    2015-04-01

    Soil microbial response after fire is controlled by numerous variables which conclude with a mosaic of results depending on organic carbon alterations or pH fire-induced changes. This fact has complicated the studies focused on post-fire microbial response, compiling high variability of opposite result in the bibliography. Soil laboratory heating cannot emulate a real wildfire effect on soil but lead us the possibility to control several variables and it is a valid tool to clarify the relative weight of different factors controlling microbial response after soil heating. In this preliminary study different heated treatments were applied to unaltered forest soil samples, obtaining 4 different heating treatments to simulate a range of fire intensities: unaltered-control (UH), and soil heated at 300, 450 and 500 °C. In order to isolate possible nutrient availability or pH heating-induced changes, different culture media were prepared using soil:water extract from each heating treatments and adding different supplements to obtain the total of 11 different culture media: unheated soil without supplements (UH-N-), unheated soil with nutrient supplement (UH-N+), soil heated at 300 °C without supplements (300-N-), soil heated at 300 °C with nutrient supplement (300-N+), soil heated at 300 °C with nutrient supplement and pH-buffered (300-N+pH); soil heated at 450 °C without supplements (450-N-), soil heated at 450 °C with nutrient supplement (450-N+), soil heated at 450 °C with nutrient supplement and pH-buffered (450-N+); soil heated at 500 °C without supplements (500-N-), soil heated at 500 °C with nutrient supplement (500-N+), soil heated at 500 °C with nutrient supplement and pH-buffered (500-N+). Each media was inoculated with different dilutions of a microbial suspension from the original unaltered soil, and the abundance of viable and cultivable microorganisms were measured by plate count method. In addition, the analysis of heating-induced soil organic

  9. Guinea pig maximization tests with formaldehyde releasers. Results from two laboratories

    Andersen, Klaus Ejner; Boman, A; Hamann, K;

    1984-01-01

    The guinea pig maximization test was used to evaluate the sensitizing potential of formaldehyde and 6 formaldehyde releasers (Forcide 78, Germall 115, Grotan BK, Grotan OX, KM 200 and Preventol D2). The tests were carried out in 2 laboratories (Copenhagen and Stockholm), and although we intended...... the procedures to be the same, discrepancies were observed, possibly due to the use of different animal strains, test concentrations and vehicles. The sensitizing potential was in general found to be stronger in Stockholm compared to Copenhagen: formaldehyde sensitized 50% of the guinea pigs in...

  10. Preliminary results on laboratory simulations of the decomposition of the green algae Ulva rigida

    The Ulva Rigida is a cosmopolitan green algae characteristic of many eutrophic and mesotrophic coastal environments. The effect of its growth and decomposition on the cycle of trace metals has been studied by using enclosures in the site Loutropyrgos over a number of years. The present study is a continuation of that research. Its main aim was to simulate a number of the field experiments in the laboratory, under more controlled conditions and understand better the impact of the decomposition of algae on sea water and sediment

  11. CHROMOSOMAL ABNORMALITIES IN PATIENTS WITH RECURRENT MISCARRIAGE

    Daniela Mierla

    2012-06-01

    Full Text Available Chromosomal abnormalities are involved in the etiology of recurrent spontaneous pregnancy loss and sub-fertility. The purpose of this study was to determine the frequency and contribution of chromosomal abnormalities in recurrent miscarriages. The results obtained and literature review are helpful in understanding the importance of cytogenetics analysis of female infertility. To investigate the distribution of chromosomal abnormalities in the Romanian population with recurrent miscarriage, karyotype analysis by G-banding was performed from peripheral blood in 967 women infertility. Results: Chromosomal abnormalities were found to 79 women (8,17%. The percentage of chromosomal abnormalities in the studied population correlates with the data in the literature. Chromosomal abnormalities could play the important role in etiology of infertility and are more frequently detected in this group of patients compared to general population. In the infertile couples balanced chromosomal abnormalities are the main cause of spontaneous abortions.

  12. Results Assessment of Intercomparison Exercise CSN/CIEMAT-2010 among Spanish National Laboratories of Environmental Radioactivity (Diet Ashes)

    This report describes the results assessment of the intercomparison exercise among environmental radioactivity laboratories, organised by Spanish Regulatory Institution (CSN) and prepared and evaluated by UAB and CIEMAT respectively. The exercise has been carried out following the international standards ISO-43 and ISO/IUPAC that provide a useful guide to perform proficiency tests and inter-laboratories comparisons. The selected matrix for this year (2010) was a diet ash obtained from the ashing of a whole fresh diet (breakfast, lunch and dinner), that was enriched with artificial radionuclides (Cs-137, Co-60,Fe-55,Ni-63,Sr-90,Am-241,Pu-238,Pu-239,240 y C-14) and contained natural radionuclides (U-234, U-238, U-natural Th-230, Th-234, Ra-226, Ra-228, Pb-210, Pb-212, Pb-214, Bi-214, Ac-228, Tl-208, K-40) at environmental level of activity concentration. The z-score test was applied to determine how much the laboratories differ from the reference value. The reference value for this exercise was the median of the results from the different laboratories and their standard deviations to achieve a more complete and objective study of the laboratories performance. The participant laboratories have demonstrated a satisfactory quality level for measuring the natural and artificial radionuclides content in this matrix. The reference values obtained through the medians show a negative bias for Pb-210 and Th-234 when comparing to the given values of external qualified laboratories from ENEA and IRSN and positive one for K-40. (Author)

  13. Chromosomal abnormalities in spontaneous abortion after assisted reproductive treatment

    Kim You

    2010-11-01

    Full Text Available Abstract Background We evaluated cytogenetic results occurring with first trimester pregnancy loss, and assessed the type and frequency of chromosomal abnormalities after assisted reproductive treatment (ART and compared them with a control group. We also compared the rate of chromosomal abnormalities according to infertility causes in ICSI group. Methods A retrospective cohort analysis was made of all patients who were referred to the Genetics Laboratory of Fertility Center of CHA Gangnam Medical Center from 2005 to 2009 because of clinical abortion with a subsequent dilation and evacuation (D&E performed, and patients were grouped by type of conception as follows: conventional IVF (in vitro fertilization (n = 114, ICSI (intracytoplasmic sperm injection (n = 140, and control (natural conception or intrauterine insemination [IUI] (n = 128. Statistical analysis was performed using SPSS software. Results A total 406 specimens were referred to laboratory, ten abortuses were excluded, and in 14 cases, we did not get any spontaneous metaphase, chromosomal constitutions of 382 specimens were successfully obtained with conventional cytogenetic methods. Overall, 52.62% of the miscarriages were found to be cytogenetically abnormal among all patients, the frequency was 48.4% in the control group, 54.3% of miscarriages after ICSI and 55.3% after conventional IVF (p = 0.503. The most prevalent abnormalities were autosomal trisomy, however, nine (11.69% sex chromosome aneuploidy were noted in the ICSI group vs. four (6.45% and two (3.23% cases in the conventional IVF group and control group. We compared chromosomal abnormalities of miscarriages after ICSI according to infertility factor. 55.71% underwent ICSI due to male factors, 44.29% due to non-male factors. ICSI group having male factors showed significantly higher risk of chromosomal abnormalities than ICSI group having non-male factors (65.8% vs. 34.2%, p = 0.009, odds ratio = 1.529, 95% CI = 1

  14. Development of a mobile laboratory for analyses at uranium cleanup sites resulting in significant time and cost savings

    A mobile laboratory was developed for the analysis of 230Th in soil at Department of Energy (DOE) Uranium Mill Tailings Remedial Action (UMTRA) sites to speed sample turnaround time and reduce the cost of using commercial laboratories. The laboratory utilizes recent developments in microwave acid dissolution, nuclide-specific extraction with extractive scintillators, and liquid scintillation alpha spectrometry to give results with an estimated minimum detectable concentration of 52 Bq kg-1 (1.4 pCi g-1) for a 300-s count using a 1-g sample. The analysis time for 230Th is 16 h for eight samples, excluding quality control samples, at a cost of approximately $30 per sample. No significant additional time or costs are incurred by performing uranium analysis. As a result savings of up to $40,000 per week can be realized on the UMTRA project

  15. Model-based reasoning in the physics laboratory: Framework and initial results

    Zwickl, Benjamin M.; Hu, Dehui; Finkelstein, Noah; Lewandowski, H. J.

    2015-12-01

    [This paper is part of the Focused Collection on Upper Division Physics Courses.] We review and extend existing frameworks on modeling to develop a new framework that describes model-based reasoning in introductory and upper-division physics laboratories. Constructing and using models are core scientific practices that have gained significant attention within K-12 and higher education. Although modeling is a broadly applicable process, within physics education, it has been preferentially applied to the iterative development of broadly applicable principles (e.g., Newton's laws of motion in introductory mechanics). A significant feature of the new framework is that measurement tools (in addition to the physical system being studied) are subjected to the process of modeling. Think-aloud interviews were used to refine the framework and demonstrate its utility by documenting examples of model-based reasoning in the laboratory. When applied to the think-aloud interviews, the framework captures and differentiates students' model-based reasoning and helps identify areas of future research. The interviews showed how students productively applied similar facets of modeling to the physical system and measurement tools: construction, prediction, interpretation of data, identification of model limitations, and revision. Finally, we document students' challenges in explicitly articulating assumptions when constructing models of experimental systems and further challenges in model construction due to students' insufficient prior conceptual understanding. A modeling perspective reframes many of the seemingly arbitrary technical details of measurement tools and apparatus as an opportunity for authentic and engaging scientific sense making.

  16. Sulfur transformations in forest litter and soil: Results of laboratory and field incubations

    Field incubations of litter and A horizon soil utilizing 35S-labeled inorganic sulfate were conducted during July 1985 in an eastern white pine (Pinus strobus L.) and a hardwood forest. Samples were assayed for the capacity to form 35S-labeled organic S, and in most cases these capacities were very similar to those determined in corresponding laboratory incubations. The A horizon soils from both watersheds formed approximately 3.0 nmol of organic S g-1 dry weight of sample during 2-d field or laboratory incubations. No substantial increase in this amount was observed after 7-d field incubations. Intrinsic S fractions of samples were quantified prior to and following field incubations, and organic S represented the majority of the total S in all cases. Total S ranged from 260 to 1180 and from 150 to 270 mg kg-1 in the litter layers and the a horizon, respectively. Sulfonate S (13-74% of total S) and nonphosphate extractable ester sulfate (16-82% of total S) were the largest organic S pools. Water soluble and phosphate extractable S pools were comprised of both inorganic sulfate and ester sulfate, and the latter was found to represent up to 8.1% of total S. The distribution of 35S following field incubations was determined, and organic 35S fractions in a variety of linkage groups were again found to predominate. Total C, moisture content, and throughfall sulfate concentrations during the field incubations were also determined

  17. Cold Climate Foundation Retrofit Experimental Hygrothermal Performance: Cloquet Residential Research Facility Laboratory Results

    Goldberg, Louise F. [NorthernSTAR, St. Paul, MN (United States); Harmon, Anna C. [NorthernSTAR, St. Paul, MN (United States)

    2015-04-01

    Thermal and moisture problems in existing basements create a unique challenge because the exterior face of the wall is not easily or inexpensively accessible. This approach addresses thermal and moisture management from the interior face of the wall without disturbing the exterior soil and landscaping. the interior and exterior environments. This approach has the potential for improving durability, comfort, and indoor air quality. This project was funded jointly by the National Renewable Energy Laboratory (NREL) and Oak Ridge National Laboratory (ORNL). ORNL focused on developing a full basement wall system experimental database to enable others to validate hygrothermal simulation codes. NREL focused on testing the moisture durability of practical basement wall interior insulation retrofit solutions for cold climates. The project has produced a physically credible and reliable long-term hygrothermal performance database for retrofit foundation wall insulation systems in zone 6 and 7 climates that are fully compliant with the performance criteria in the 2009 Minnesota Energy Code. The experimental data were configured into a standard format that can be published online and that is compatible with standard commercially available spreadsheet and database software.

  18. Memetics clarification of abnormal behavior

    2007-01-01

    AIM: Biological medicine is hard to fully and scientifically explain the etiological factor and pathogenesis of abnormal behaviors; while, researches on philosophy and psychology (including memetics) are beneficial to better understand and explain etiological factor and pathogenesis of abnormal behaviors. At present, the theory of philosophy and psychology is to investigate the entity of abnormal behavior based on the views of memetics.METHODS: Abnormal behavior was researched in this study based on three aspects, including instinctive behavior disorder, poorly social-adapted behavior disorder and mental or body disease associated behavior disorder. Most main viewpoints of memetics were derived from "The Meme Machine", which was written by Susan Blackmore. When questions about abnormal behaviors induced by mental and psychological diseases and conduct disorder of teenagers were discussed, some researching achievements which were summarized by authors previously were added in this study, such as aggressive behaviors, pathologically aggressive behaviors, etc.RESULTS: The abnormal behaviors mainly referred to a part of people's substandard behaviors which were not according with the realistic social environment, culture background and the pathologic behaviors resulted from people's various psychological diseases. According to the theory of "meme", it demonstrated that the relevant behavioral obstacles of various psychological diseases, for example, the unusual behavior of schizophrenia, were caused, because the old meme was destroyed thoroughly but the new meme was unable to establish; psychoneurosis and personality disorder were resulted in hard establishment of meme; the behavioral obstacles which were ill-adapted to society, for example, various additional and homosexual behaviors, were because of the selfish replications and imitations of "additional meme" and "homosexual meme"; various instinct behavioral and congenital intelligent obstacles were not significance

  19. Early effects of water inflow into a deposition hole. Laboratory tests results

    material continuously measured. The results from all tests were well within the limits of the erosion model. The erosion rate was in all tests in the lower range of the model which probably depends on the fact that the tests were performed in vertical direction with upwards flow. An interesting result from the tests (Test type 1) was that the buffer blocks moved upwards when water was filled into the surrounding pellets, but the movements did not seem to depend on swelling of the blocks. Instead the heave seemed to depend on a high relative humidity in the pellets filling which made the blocks crack and by that cause an upwards movement. The long term test verified that the decrease of the erosion rate with time that have been measured in earlier tests and is predicted in the model seemed to continue for long time and for large water volumes. With the performed laboratory tests as basis, analysis of the processes related to water inflow into a deposition hole have been made. The processes may lead to unacceptable reduction in buffer density during the installation and water saturation phases. There are mainly two processes that may be detrimental to the buffer. One of them occurs during installation before the backfill has been placed on top of the deposition hole. The inflowing water will cause a heave of the buffer blocks, which may cause unacceptably decrease in density of the buffer material around the canister. The other process is erosion that will take place when water flows out from the deposition hole into the tunnel in channels formed in the pellets filling. The criterion for acceptable heave of the buffer blocks before installation of backfill on top of the deposition hole is suggested to be one cm and the maximum allowable water inflow rate that causes such a heave within four days was found to be 0.1 l/min. The criterion for acceptable loss of bentonite in one spot in a deposition hole is suggested to be 100 kg. The allowable inflow rate that limits the amount

  20. Test Results From The Idaho National Laboratory 15kW High Temperature Electrolysis Test Facility

    Carl M. Stoots; Keith G. Condie; James E. O' Brien; J. Stephen Herring; Joseph J. Hartvigsen

    2009-07-01

    A 15kW high temperature electrolysis test facility has been developed at the Idaho National Laboratory under the United States Department of Energy Nuclear Hydrogen Initiative. This facility is intended to study the technology readiness of using high temperature solid oxide cells for large scale nuclear powered hydrogen production. It is designed to address larger-scale issues such as thermal management (feed-stock heating, high temperature gas handling, heat recuperation), multiple-stack hot zone design, multiple-stack electrical configurations, etc. Heat recuperation and hydrogen recycle are incorporated into the design. The facility was operated for 1080 hours and successfully demonstrated the largest scale high temperature solid-oxide-based production of hydrogen to date.

  1. Comparison of a laboratory spectrum of Eu-152 with results of simulation using the MCNP code

    Rodenas, J. [Departamento de Ingenieria Quimica y Nuclear, Universidad Politecnica de Valencia, Apartado 22012, E-46071 Valencia (Spain); Gallardo, S. [Departamento de Ingenieria Quimica y Nuclear, Universidad Politecnica de Valencia, Apartado 22012, E-46071 Valencia (Spain)], E-mail: sergalbe@iqn.upv.es; Ortiz, J. [Laboratorio de Radiactividad Ambiental, Universidad Politecnica de Valencia, Apartado 22012, E-46071 Valencia (Spain)

    2007-09-21

    Detectors used for gamma spectrometry must be calibrated for each geometry considered in environmental radioactivity laboratories. This calibration is performed using a standard solution containing gamma emitter sources. Nevertheless, the efficiency curves obtained are periodically checked using a source such as {sup 152}Eu emitting many gamma rays that cover a wide energy range (20-1500 keV). {sup 152}Eu presents a problem because it has a lot of peaks affected by True Coincidence Summing (TCS). Two experimental measures have been performed placing the source (a Marinelli beaker) at 0 and 10 cm from the detector. Both spectra are simulated by the MCNP 4C code, where the TCS is not reproduced. Therefore, the comparison between experimental and simulated peak net areas permits one to choose the most convenient peaks to check the efficiency curves of the detector.

  2. Holoprosencephaly due to Numeric Chromosome Abnormalities

    Solomon, Benjamin D.; Rosenbaum, Kenneth N.; Meck, Jeanne M.; Muenke, Maximilian

    2010-01-01

    Holoprosencephaly (HPE) is the most common malformation of the human forebrain. When a clinician identifies a patient with HPE, a routine chromosome analysis is often the first genetic test sent for laboratory analysis in order to assess for a structural or numerical chromosome anomaly. An abnormality of chromosome number is overall the most frequently identified etiology in a patient with HPE. These abnormalities include trisomy 13, trisomy 18, and triploidy, though several others have been ...

  3. Report of the research results with University of Tokyo Nuclear Engineering Research Laboratory's facilities in fiscal 1975

    Results of the research works by educational institutions using fast neutron source reactor 'Yayoi' etc. of Nuclear Engineering Research Laboratory in fiscal 1975 are reported in individual summaries. Fields of research are the following: shielding benchmark experiment, research on medical irradiation, irradiation experiments, experiments by small research groups, fast neutron streaming experiment, and so on. (Mori, K.)

  4. Evaluation of selected martensitic stainless steels for use in downhole tubular expansion - Results of a laboratory study

    Mack, Robert [Shell International E and P, b.v. Kessler Park 1, Postbus 60, 2280 AB Rijswijk (Netherlands)

    2004-07-01

    A laboratory program was performed to evaluate the potential of selected martensitic stainless steels for downhole cladding applications. The evaluation of the effects of tubular expansion on mechanical properties, defects, and resistance to environmentally assisted cracking demonstrated that some steels were acceptable for the intended application. The results were used to qualify and select the stainless steel for the intended sweet cladding applications. (authors)

  5. STANDARDIZATION OF GLYCOHEMOGLOBIN RESULTS AND REFERENCE VALUES IN WHOLE-BLOOD STUDIED IN 103 LABORATORIES USING 20 METHODS

    WEYKAMP, CW; PENDERS, TJ; MUSKIET, FAJ; VANDERSLIK, W

    1995-01-01

    We investigated the effect of calibration with lyophilized calibrators on whole-blood glycohemoglobin (glyHb) results. One hundred three laboratories, using 20 different methods, determined glyHb in two lyophilized calibrators and two whole-blood samples. For whole-blood samples with low (5%) and hi

  6. Results of laboratory and in-situ measurements for the description of coupled thermo-hydro-mechanical processes in clays

    The Heater Experiment at the Mont Terri Underground Laboratory aims at producing a validated model of thermo-hydro-mechanically (THM) coupled processes. The experiment consists of an engineered barrier system where in a vertical borehole, a heater is embedded in bentonite blocks, surrounded by the host rock, Opalinus Clay. The experimental programme comprises permanent monitoring before, during, and after the heating phase, complemented by geotechnical, hydraulic, and seismic in-situ measurements as well as laboratory analyses of mineralogical and rock mechanics properties. After the heating, the experiment was dismantled for further investigations. Major results of the experimental findings are outlined. (authors)

  7. Clinical and laboratory characteristics of 16 patients with acute lymphoblastic leukemia (ALL) harboring 19p13 abnormalities%16例伴19p13异常急性淋巴细胞白血病患者的临床和实验室研究

    贡金英; 竺晓凡; 刘旭平; 陈玉梅; 邹尧; 秘营昌; 王建祥

    2009-01-01

    Objective To investigate the clinical and laboratory characteristics of patients with acute lymphoblastie leukemia (ALL) bearing 19p13 abnormalities. Methods The morphologic, immunophenotyp- ic, cytogenetie, and clinal features as well as prognosis of 16 ALL patients with 19p13 abnormalities were retrospectively analyzed. The clinical features and laboratory findings between t(1;19) and der(19) groups were compared. Results Sixteen (4.02%)out of 398 ALL patients had 19p13 abnormalities, among them 15 cases were t (1 ; 19) (q23 ; p 13) [balanced t (1 ; 19) (q23 ; p 13} in 8 and unbalanced der (19) t (1 ; 19) (q23 ;p13} in 7] and 1 case t(17;19)(q22;p13). The W BC count and blast cell number were higher in the t (1 ; 19) group. The prognosis was better in der(19) t(1 ; 19) group than in balanced translocation t(1 ; 19) group. Conclusion The 19p13 abnormality is one of the non-random chromosomal aberration in patients with ALL. ALL patients with 19p13 abnormalities have unique clinical features and poor prognosis.%目的 分析伴19p13异常的急性淋巴细胞白血病(ALL)患者的临床和实验室特征:方法 对16例伴19p13异常的ALL患者的细胞形态学、免疫学、细胞遗传学和临床特点进行回顾性分析,并对t(1;19)组和der(19)组的临床和实验室资料进行对比分析.结果 伴19p13异常的ALL占同期ALL的4.02%,其中t(1;19)(q23;p13)15例[平衡易位t(1;19)(q23;p13)8例,不平衡易位der(19)t(1;19)(q23;p13)7例],t(17;19)(q22;p13)1例,t(1;19)组的外周血门细胞汁数和骨髓原始幼稚淋巴细胞比例明显高于der(19)组,而der(19)组的预后较t(1;19)组好.结论 19p13异常是ALL的一个非随机的染色体改变;伴有该异常的ALL患者具有独特的I临床特征和小良预后.

  8. Full-scale laboratory simulation facility to test particulate and organic emissions from a Third World residential combustion process. 1. Facility description and results of tests of three rural China residential coals, a U.S. coal, and wood

    The paper gives results of a series of 12 tests for 3 coals from a rural area of China with abnormally high lung cancer rates, a U.S. coal, and pine wood fuel. It also discusses a residential combustion simulator, built at EPA's Research Triangle Park, NC, facility to conduct emission tests of residential fuels in a facility designed for the acquisition of samples for chemical and biological analysis. The facility includes a 2.5 by 3.0 m burn hut (containing a 30 by 30 cm fire pit) located next to an instrumentation and control building. Air samples can be taken inside the burn hut or from an insulated duct pulling samples from the center of the hut through the control building. Additional sampling systems, such as continuous emission monitors or laboratory grade chemical analyzers, can be easily added either in the instrumentation building or by parking a mobile laboratory next to the facility

  9. An experimental platform for creating white dwarf photospheres in the laboratory: Preliminary results

    Montgomery, M. H.; Falcon, Ross E.; Rochau, G. A.; Bailey, J. E.; Gomez, T. A.; Carlson, A. L.; Bliss, D. E.; Nagayama, T.; Stein, M.; Winget, D. E.

    2015-12-01

    We present the current status of the White Dwarf Photosphere Experiment at the Z Pulsed Power Facility at Sandia National Laboratories. This experiment has evolved into a unique platform for simultaneously measuring emission, absorption, and back-lighter continua spectra of plasmas with white dwarf (WD) photospheric compositions and conditions (Te∼1 eV, ne∼1016-1018e/cm3); our current experiments involve line profile measurements of hydrogen-corresponding to the most common surface composition in white dwarf stars, with future experiments planned for helium, carbon, and oxygen. These profiles will test line broadening theories used in white dwarf model atmospheres to infer the fundamental parameters (e.g., effective temperature and mass) of thousands of WDs. This experiment uses the large amount of x-rays generated from a z-pinch dynamic hohlraum to radiatively drive plasma formation in a gas cell. We reach significantly higher densities than the landmark study of Wiese et al. (1972), thereby putting competing line broadening theories to the test in a regime where their predictions strongly diverge. The simultaneous measurement of emission, absorption, and back-lighter continua in macroscopic plasmas represents a significant advance relative to hydrogen line profile experiments of the past.

  10. Laboratory spectroscopy of Mars Analogue materials and latest field results from Iceland and Eifel

    Offringa, Marloes; Foing, Bernard H.

    2016-07-01

    We have established a collection of samples, and measured them in the laboratory towards a spectrometric database that could be used as a reference for future orbital or in situ measurements. We are using systematically for all samples UV-VIS and NIR reflectance spectrometers, and sporadically a Fourier Transform Infrared (FTIR) spectrometer, an X-Ray Fluorescence (XRF) spectrometer and a Raman laser spectrometer on control samples. We also used a documented set of Moon-Mars relevant minerals curated at VU Amsterdam, as well as samples retrieved from Mars analogue campaigns in Utah (Foing et al., 2011, 2016), Iceland (Mid-Atlantic ridge spreading and magma-ice interaction), La Réunion hot spot volcano and Eifel volcanic region (mixed hotspot and melt-ascent through crust fractures) from recent campaigns in 2015 and 2016.. We discuss samples spectral diagnostics of volcanic processes and hydrous alterations that can inform recent or upcoming measurements from Mars orbit or in situ rovers. Acknowledgements: we thank Dominic Doyle for ESTEC optical lab support, Euan Monaghan (Leiden U) for FTIR measurement support, Wim van Westrenen for access to VU samples, Oscar Kamps (Utrecht U), Aidan Cowley (EAC) and Matthias Sperl (DLR) for support discussions

  11. Results from the geological surveys carried out in the Bure laboratory's drifts

    Document available in extended abstract form only. After the government's authorization to build and operate an underground laboratory, Andra started the investigation works in November 99 on the Meuse/Haute-Marne URL site. The Meuse/Haute-Marne URL is located at the border of the Champagne-Ardenne and Lorraine regions, on the township of Bure in the Callovo-Oxfordian clay-rich rock. At this place, the layer is about 135 m-thick and lies at a depth of 417 m to 552 m. The construction of the underground installations started in August 2000 with the sinking of the main shaft and the first phase of diggings was completed on the 27 April 2006 when it linked up with the south drift of the laboratory. The laboratory consists in two vertical shafts crossing the 505-m thick sedimentary cover and two levels of experimental drifts dug in Callovo-Oxfordian formation. The first experimental drift dug at -445 m with a drill-and-blast method with steps of 2.4 m. The technical and experimental drifts at the main level (-490 m of depth) were dug with a hydraulic stone crusher. The aims of the geological surveys carried out during the drifts digging are to observe the lateral variation of the lithology, if there is one, to confirm the absence of fault and the geometry of the argillites formation. These works should also allow to characterize the natural or inducted fracturing (EDZ - Excavation Damaged Zone) induced by the digging by a sedimentary and structural follow-up. The EDZ characterization has been established from the geological survey of the drift face and sidewalls carried out from 1 to 5 meters in the drifts, and completed by the structural analysis of the cores of the boreholes drilled for the experimentations' equipments. After the safe keeping of the front, the geological team goes down to carry out the survey which consists in a lithologic and sedimentary mapping, a structural survey for the understanding of joints distribution and EDZ characterization, and

  12. Urine - abnormal color

    The usual color of urine is straw-yellow. Abnormally colored urine may be cloudy, dark, or blood-colored. ... Abnormal urine color may be caused by infection, disease, medicines, or food you eat. Cloudy or milky urine is a sign ...

  13. Effects of a chelating resin on metal bioavailability and toxicity to estuarine invertebrates: Divergent results of field and laboratory tests

    Wilkie, Emma M., E-mail: ewilkie@bio.mq.edu.a [Department of Environmental Sciences, University of Technology Sydney, Broadway, NSW 2007 (Australia); Ecotoxicology and Environmental Contaminants Section, Department of Environment and Climate Change, Lidcombe, NSW 1825 (Australia); Roach, Anthony C. [Ecotoxicology and Environmental Contaminants Section, Department of Environment and Climate Change, Lidcombe, NSW 1825 (Australia); Micevska, Tina [Centre for Environmental Contaminants Research, CSIRO Land and Water, Menai, NSW 2234 (Australia); Kelaher, Brendan P.; Bishop, Melanie J. [Department of Environmental Sciences, University of Technology Sydney, Broadway, NSW 2007 (Australia)

    2010-05-15

    Benthic invertebrates can uptake metals through diffusion of free ion solutes, or ingestion of sediment-bound forms. This study investigated the efficacy of the metal chelating resin SIR 300{sup TM} in adsorbing porewater metals and isolating pathways of metal exposure. A field experiment (Botany Bay, Sydney, Australia) and a laboratory toxicity test each manipulated the availability of porewater metals within contaminated and uncontaminated sediments. It was predicted that within contaminated sediments, the resin would adsorb porewater metals and reduce toxicity to invertebrates, but in uncontaminated sediments, the resin would not significantly affect these variables. Whereas in the laboratory, the resin produced the predicted results, in the field the resin increased porewater metal concentrations of contaminated sediments for at least 34 days and decreased abundances of four macroinvertebrate groups, and richness in all sediments. These contrasting findings highlight the limits of extrapolating the results of laboratory experiments to the field environment. - Laboratory experiments do not predict the effects on porewater metals or macroinvertebrates of adding a chelating resin to metal-contaminated field sediments.

  14. Effects of a chelating resin on metal bioavailability and toxicity to estuarine invertebrates: Divergent results of field and laboratory tests

    Benthic invertebrates can uptake metals through diffusion of free ion solutes, or ingestion of sediment-bound forms. This study investigated the efficacy of the metal chelating resin SIR 300TM in adsorbing porewater metals and isolating pathways of metal exposure. A field experiment (Botany Bay, Sydney, Australia) and a laboratory toxicity test each manipulated the availability of porewater metals within contaminated and uncontaminated sediments. It was predicted that within contaminated sediments, the resin would adsorb porewater metals and reduce toxicity to invertebrates, but in uncontaminated sediments, the resin would not significantly affect these variables. Whereas in the laboratory, the resin produced the predicted results, in the field the resin increased porewater metal concentrations of contaminated sediments for at least 34 days and decreased abundances of four macroinvertebrate groups, and richness in all sediments. These contrasting findings highlight the limits of extrapolating the results of laboratory experiments to the field environment. - Laboratory experiments do not predict the effects on porewater metals or macroinvertebrates of adding a chelating resin to metal-contaminated field sediments.

  15. Groundwater monitoring at three Oak Ridge National Laboratory inactive waste impoundments: results after one year

    To determine if the migration of potential contaminants from three inactive waste impoundments at Oak Ridge National Laboratory poses a threat to groundwater quality, at least one upgradient groundwater monitoring well and threee downgradient monitoring wells were installed at each impoundment in early 1985. These three unlined impoundments, formerly used to collect and, in some instances, treat wastewater are: the 3513 impoundment; the Old Hydrofracture Facility (OHF) impoundment; and the Homogeneous Reactor Experimnt No. 2 impoundment. Groundwater samples were collected quarterly for one year. Analyses were conducted for the groundwater protection parameters promulgated by the Resource Conservation and Recovery Act. The groundwater samples were also analyzed for polychlorinated biphenyls, copper, nickel, zinc, 90Sr, 137Cs, and tritium. The contaminants found most often to affect groundwater quality at all three waste impoundments were radionuclides. For example, mean concentrations of gross beta and gross alpha activity exceeded drinking water limits at all three sites. The gross beta limit was exceeded at the 3513 and OHF impoundments by either 90Sr or tritium levels. At the 3513 impoundment, there was substantial evidence that the downgradient groundwater has been contaminated by chromium and lead and possibly by halogenated organic compounds. At the OHF impoundment, the mean level of tritium measured in the upgradient well (about 91,000 Bq/L as compared with 80,000 Bq/L in the downgradient wells) indicated that the groundwater quality has been affected by the radioactive wastes buried in the low-level radioactive waste burial ground solid waste storage area-5 upgradient of the impoundment. Testing for groundwater contamination, disclosed statistically significant contamination at all three sites

  16. Gravity Recovery and Interior Laboratory (GRAIL) Mission: Mission Status and Initial Science Results

    Neumann, Gregory A.

    2012-01-01

    The Gravity Recovery and Interior Laboratory (GRAIL) Mission is a component of the NASA Discovery Program. GRAIL is a twin-spacecraft lunar gravity mission that has two primary objectives: to determine the structure of the lunar interior, from crust to core; and to advance understanding of the thermal evolution of the Moon. GRAIL launched successfully from the Cape Canaveral Air Force Station on September 10, 2011, executed a low-energy trajectory to the Moon, and inserted the twin spacecraft into lunar orbit on December 31, 2011 and January 1, 2012. A series of maneuvers brought both spacecraft into low-altitude (55-km), near-circular, polar lunar orbits, from which they perform high-precision satellite-to-satellite ranging using a Ka-band payload along with an S-band link for time synchronization. Precise measurements of distance changes between the spacecraft are used to map the lunar gravity field. GRAIL completed its primary mapping mission on May 29, 2012, collecting and transmitting to Earth >99.99% of the possible data. Spacecraft and instrument performance were nominal and has led to the production of a high-resolution and high-accuracy global gravity field, improved over all previous models by two orders of magnitude on the nearside and nearly three orders of magnitude over the farside. The field is being used to understand the thickness, density and porosity of the lunar crust, the mechanics of formation and compensation states of lunar impact basins, and the structure of the mantle and core. GRAIL s three month-long-extended mission will initiate on August 30, 2012 and will consist of global gravity field mapping from an average altitude of 22 km.

  17. Initial experimental results from the laboratory biosphere closed ecological system facility

    Nelson, M.; Dempster, W. F.; Alling, A.; Allen, J. P.; Rasmussen, R.; Silverstone, S.; Van Thillo, M.

    An initial experiment in the Laboratory Biosphere facility, Santa Fe, New Mexico, was conducted May-August 2002 using a soil-based system with light levels (at 12 h per day) of 58-mol m -2 d -1. The crop tested was soybean, cultivar Hoyt, which produced an aboveground biomass of 2510 grams. Dynamics of a number of trace gases showed that methane, nitrous oxide, carbon monoxide, and hydrogen gas had initial increases that were substantially reduced in concentration by the end of the experiment. Methane was reduced from 209 ppm to 11 ppm, and nitrous oxide from 5 ppm to 1.4 ppm in the last 40 days of the closure experiment. Ethylene was at elevated levels compared to ambient during the flowering/fruiting phase of the crop. Soil respiration from the 5.37m 2 (1.46m 3) soil component was estimated at 23.4 ppm h -1 or 1.28 g CO 2 h -1 or 5.7 g CO 2 m -2 d -1. Phytorespiration peaked near the time of fruiting at about 160 ppm h -1. At the height of plant growth, photosynthesis CO 2 draw down was as high as 3950 ppm d -1, and averaged 265 ppm h -1 (whole day averages) during lighted hours with a range of 156 - 390 ppm h -1. During this period, the chamber required injections of CO 2 to continue plant growth. Oxygen levels rose along with the injections of carbon dioxide. Upon several occasions, CO 2 was allowed to be drawn down to severely limiting levels, bottoming at around 150 ppm. A strong positive correlation (about 0.05 ppm h -1 ppm -1 with r 2 about 0.9 for the range 1000 - 5000 ppm) was observed between atmospheric CO 2 concentration and the rate of fixation up to concentrations of around 8800 ppm CO 2.

  18. Results from the first national UK inter-laboratory calibration for very short-lived halocarbons

    C. E. Jones

    2011-01-01

    Full Text Available Very short-lived halocarbons (VSLH such as CH3I, CH2Br2 and CHBr3 provide an important source of reactive halogens to the atmosphere, however high spatial and seasonal variability in their ambient mixing ratios and sea-air fluxes gives rise to considerable uncertainty in global scale emission estimates. One solution to improve global flux estimates is to combine the multitude of individually published datasets to produce a database of collated global halocarbon observations. Some progress towards this has already been achieved through the HalOcAt (Halocarbons in the Ocean and Atmosphere database initiative, however the absence of a common calibration scale for very short-lived halocarbons makes it difficult to distinguish true environmental variations from artefacts arising from differences between calibration methodologies. As such, the lack of inter-calibrations for both air and seawater measurements of very short-lived halocarbons has been identified as a major limitation to current estimations of the global scale impact of these reactive trace gases. Here we present the key findings from the first national UK inter-laboratory comparison for calibrations of the halocarbons CH3I, CH2Br2 and CHBr3. The aim of this inter-calibration was to provide transparency between halocarbon calibrations from major UK research institutions, an important step towards enabling all measurements from these institutions to be treated as one coherent integrated dataset for global source term parameterisations.

  19. Results from the first national UK inter-laboratory calibration for very short-lived halocarbons

    C. E. Jones

    2011-05-01

    Full Text Available Very short-lived halocarbons (VSLH such as CH3I, CH2Br2 and CHBr3 provide an important source of reactive halogens to the atmosphere, however high spatial and seasonal variability in their ambient mixing ratios and sea-air fluxes gives rise to considerable uncertainty in global scale emission estimates. One solution to improve global flux estimates is to combine the multitude of individually published datasets to produce a database of collated global halocarbon observations. Some progress towards this has already been achieved through the HalOcAt (Halocarbons in the Ocean and Atmosphere database initiative, but the absence of a common calibration scale for very short-lived halocarbons makes it difficult to distinguish true environmental variations from artefacts arising from differences between calibration methodologies. As such, the lack of inter-calibrations for both air and seawater measurements of very short-lived halocarbons has been identified as a major limitation to current estimations of the global scale impact of these reactive trace gases. Here we present the key findings from the first national UK inter-laboratory comparison for calibrations of the halocarbons CH3I, CH2Br2 and CHBr3. The aim of this inter-calibration was to provide transparency between halocarbon calibrations from major UK research institutions, an important step towards enabling all measurements from these institutions to be treated as one coherent integrated dataset for global source term parameterisations.

  20. Results of an EC laboratory comparison on 40K, 90Sr and 137Cs in dried bilberry powder

    The evaluation is presented of a laboratory comparison (LC) on 90Sr, 40K and 137Cs in dried bilberries organised in 2011 by the IRMM. The activity concentrations reported by 88 participant laboratories are compared to the reference values of the new reference material IRMM-426 Wild Berries. Nine per cent and 17% of activity concentration results for 137Cs and 40K, respectively, deviate more than 20% from the reference values, a result worse than that obtained in previous LCs. For 90Sr, about 88% of results lie within 30% of the reference value, better than observed in previous LCs. But only 58% of 90Sr results are satisfactory in terms of the En criterion, indicating difficulties with a complete uncertainty estimation. - Highlights: • New CRM IRMM-426 Wild Berries was used as test material. • Only 91% and 83% of 137Cs and 40K results within 20% of reference values. • Good performance for 90Sr: 88% within 30% of reference values. • For many labs, discrepant evaluation to En criterion and relative deviations. • Many laboratories cannot estimate realistic uncertainties (137Cs, 90Sr)

  1. Knee loading for abnormal gait

    Hutchison, J.; Madsen, D.; Norman, T. L.; -Blaha, J. D.

    2014-01-01

    The purpose of the study was to develop a mathematical model for determining knee loads for abnormal gait. Abnormal gait was defined as a person with varus, i.e. “bowleggedness”, or a person who had an external rotation of the femur (or the inability to internally rotate the femur) which caused an indirect varus in the forward positions of gait. Conditions such as these have been observed clinically to result in increased wear on the medial condyle of total knee replacements. This problem was...

  2. Thyroid abnormality in perimenopausal women with abnormal uterine bleeding

    Prasanna Byna

    2015-11-01

    Full Text Available Background: AUB is a common but complicated clinical presentation and occurs in 15-20% of women between menarche to menopause and significantly affects the women's health. Women with thyroid dysfunction often have menstrual irregularities, infertility and increased morbidity during pregnancy. The objective of present study is to find the correlation between thyroid disorders and AUB in perimenopausal women attending gynecology OPD. Methods: In the present study, fifty five patients with AUB were included and were evaluated for the cause including thyroid abnormality. Thyroid function tests were done in all patients. Results: Among 55 patients, 12 patients were diagnosed as hypothyroidism and 7 as hyperthyroidism, women with AUB 36 (65.4% were euthyroid. Among 19 women with thyroid abnormality, heavy menstrual bleeding was seen in 8 (42% women, 6 (31.57% had polymenorrhagia, 5 (26.31% had oligomenorrhoea. The frequent menstrual abnormality in women with hypothyroidism (12 women was heavy menstrual bleeding in 5 (41.6% women, 3 (25% had oligomennorhoea, 4 (33.3% had polymenorrhagia. Out of 7 women with hyperthyroidism, 2 (28.57% had oligomenorrhoea, 3 (42.8% had heavy menstrual bleeding, 2 (28.57% had polymenorrhagia. In a total of 55 patients with AUB, 11 (20% had structural abnormalities in uterus and ovaries. 5 (9% had adenomyosis, 3 (5.4% had ovarian cysts, 3 (5.4% had fibroids. Conclusions: It is important to screen all women for thyroid abnormality who are presenting with AUB especially with non-structural causes of AUB. Correction of thyroid abnormalities also relieves AUB. This will avoid unnecessary hormonal treatment and surgery. [Int J Res Med Sci 2015; 3(11.000: 3250-3253

  3. SERUM CHEMISTRY ABNORMALITIES IN CHILDREN WITH UNPROVOKED SEIZURES

    J. Akhondian MD,

    2007-02-01

    Full Text Available ObjectiveMost children brought to the emergency department (ED for evaluation of seizures undergo an extensive laboratory workup. Since results are usually negative, the value of such routine laboratory workups has been questioned. A group of children with unprovoked seizures was prospectively studied to determine the diagnostic values of routine serum chemistries and to identify risk factors predictive of abnormal findings.Materials & MethodsAll patients evaluated at the ED of the Ghaem hospital during a consecutive 12 months period between Jan 2004 through Jan 2005 were studied. We collected data for patient's demographics, details of the history of present illness (including vomiting, diarrhea, apnea, medication use, past history of seizures, family history of seizures, metabolic disorders or other chronic medical illnesses, neonatal history and neurological examination as well as nutritional status, type and time of seizure. The role of abnormal serum chemistries as a seizure trigger factor was assessed in patients with a history of seizure.ResultsA total of 210 patients (mean age 19.2 months with unprovoked seizures were evaluated. Twenty- three serum abnormalities were noted in the patients (12 cases of hyponatremia, 7 of hypoglycemia, 4 of hypokalemia, 4 of uremia. The incidence of abnormal serum biochemical values was higher in patients with a first seizure, younger patients, and those with gastrointestinal symptoms.ConclusionAccording to the present study, one can conclude that in children younger than 2 years and having no structural CNS abnormality, electrolyte and glucose screening is recommended only for a first unprovoked seizure, when gastrointestinal symptoms or symptoms suggesting electrolyte disturbances are present.

  4. SERUM CHEMISTRY ABNORMALITIES IN CHILDREN WITH UNPROVOKED SEIZURES

    J. Akhondian MD

    2009-01-01

    Full Text Available ObjectiveMost children brought to the emergency department (ED for evaluation of seizures undergo an extensive laboratory workup. Since results are usually negative, the value of such routine laboratory workups has been questioned. A group of children with unprovoked seizures was prospectively studied to determine the diagnostic values of routine serum chemistries and to identify risk factors predictive of abnormal findings.Materials & MethodsAll patients evaluated at the ED of the Ghaem hospital during a consecutive 12 months period between Jan 2004 through Jan 2005 were studied. We collected data for patient's demographics, details of the history of present illness (including vomiting, diarrhea, apnea, medication use, past history of seizures, family history of seizures, metabolic disorders or other chronic medical illnesses, neonatal history and neurological examination as well as nutritional status, type and time of seizure. The role of abnormal serum chemistries as a seizure trigger factor was assessed in patients with a history of seizure.ResultsA total of 210 patients (mean age 19.2 months with unprovoked seizures were evaluated. Twenty- three serum abnormalities were noted in the patients (12 cases of hyponatremia, 7 of hypoglycemia, 4 of hypokalemia, 4 of uremia. The incidence of abnormal serum biochemical values was higher in patients with a first seizure, younger patients, and those with gastrointestinal symptoms.ConclusionAccording to the present study, one can conclude that in children younger than 2 years and having no structural CNS abnormality, electrolyte and glucose screening is recommended only for a first unprovoked seizure, when gastrointestinal symptoms or symptoms suggesting electrolyte disturbances are present.Keywords:Unprovoked, Seizure, Biochemistry, Children

  5. Flue gas conditioning for improved particle collection in electrostatic precipitators. First topical report, Results of laboratory screening of additives

    Durham, M.D.

    1993-04-16

    Several tasks have been completed in a program to evaluate additives to improve fine particle collection in electrostatic precipitators. Screening tests and laboratory evaluations of additives are summarized in this report. Over 20 additives were evaluated; four were found to improve flyash precipitation rates. The Insitec particle analyzer was also evaluated; test results show that the analyzer will provide accurate sizing and counting information for particles in the size range of {le} 10 {mu}m dia.

  6. Guidelines for laboratory testing and result reporting of antibody to hepatitis C virus. Centers for Disease Control and Prevention.

    Alter, Miriam J; Kuhnert, Wendi L; Finelli, Lyn

    2003-02-01

    Testing for the presence of antibody to hepatitis C virus (anti-HCV) is recommended for initially identifying persons with hepatitis C virus (HCV) infection (CDC. Recommendations for prevention and control of hepatitis C virus [HCV] infection and HCV-related chronic disease. MMWR 1998;47[No. RR-19] :1-33). Testing for anti-HCV should include use of an antibody screening assay, and for screening test-positive results, a more specific supplemental assay. Verifying the presence of anti-HCV minimizes unnecessary medical visits and psychological harm for persons who test falsely positive by screening assays and ensures that counseling, medical referral, and evaluation are targeted for patients serologically confirmed as having been infected with HCV. However, substantial variation in reflex supplemental testing practices exists among laboratories, and an anti-HCV-positive laboratory report does not uniformly represent a confirmed positive result. These guidelines expand recommendations for anti-HCV testing to include an option for reflex supplemental testing based on screening-test-positive signal-to-cut-off (s/co) ratios. Use of s/co ratios minimizes the amount of supplemental testing that needs to be performed while improving the reliability of reported test results. These guidelines were developed on the basis of available knowledge of CDC staff in consultation with representatives from the Food and Drug Administration and public health, hospital, and independent laboratories. Adoption of these guidelines by all public and private laboratories that perform in vitro diagnostic anti-HCV testing will improve the accuracy and utility of reported anti-HCV test results for counseling and medical evaluation of patients by health-care professionals and for surveillance by public health departments. PMID:12585742

  7. Influence of clinical and laboratory variables on faecal antigen ELISA results in dogs with canine parvovirus infection.

    Proksch, A L; Unterer, S; Speck, S; Truyen, U; Hartmann, K

    2015-06-01

    False negative faecal canine parvovirus (CPV) antigen ELISA results in dogs with CPV infection are common, but the factors that lead to these false negative results are still unknown. The aim of this study was to investigate whether dogs with a false negative faecal CPV antigen ELISA result have milder clinical signs and laboratory changes, a lower faecal virus load, higher faecal and serum CPV antibody titres and a faster recovery than dogs with a positive result. Eighty dogs with CPV infection, confirmed by the presence of clinical signs and a positive faecal CPV polymerase chain reaction (PCR), were assigned to two groups according to their faecal antigen ELISA result. Time until presentation, severity of symptoms, laboratory parameters, faecal virus load, faecal and serum antibody titres, and CPV sequencing data were compared between both groups. In 38/80 dogs that were hospitalised until recovery, the time to recovery, mortality, and the course of the disease were compared between dogs with positive and negative faecal antigen ELISA results. Of the 80 dogs included, 41 (51.3%) had a false negative faecal antigen ELISA result. ELISA-negative dogs had a significantly shorter time until presentation, lower frequency of defaecation, lower faecal virus load, and higher serum antibody concentrations than ELISA-positive dogs. Laboratory changes, CPV shedding, and outcomes were not associated with faecal antigen ELISA results. In conclusion, low faecal CPV load and antibodies binding to CPV antigen in faeces are likely to be important reasons for false negative faecal antigen ELISA results. Dogs with clinical signs of CPV infection should be retested by faecal PCR. PMID:25920770

  8. CHROMOSOMAL ABNORMALITIES IN PATIENTS WITH RECURRENT MISCARRIAGE

    Daniela Mierla; Viorica Radoi; Veronica Stoian

    2012-01-01

    Chromosomal abnormalities are involved in the etiology of recurrent spontaneous pregnancy loss and sub-fertility. The purpose of this study was to determine the frequency and contribution of chromosomal abnormalities in recurrent miscarriages. The results obtained and literature review are helpful in understanding the importance of cytogenetics analysis of female infertility. To investigate the distribution of chromosomal abnormalities in the Romanian population with recurrent miscarriage, ka...

  9. Do Stock Dividends Generate Abnormal Returns?

    Torgal, Kishan

    2009-01-01

    In this paper I have studied and understood the concepts of stock dividends, stock splits and the announcement effects and the effective day effects by using the standard event studies methodology which measures the significance of the abnormal returns. The previous studies have significant positive abnormal returns. In my results its shown that the as there is some significant abnormal returns which are connected with the announcement and effective day of the stock splits but it changes...

  10. The USAF Phillips Laboratory sodium-sulfur battery technology program: Results and status

    Rainbow, Marc E.; Somerville, Andrew

    1996-01-01

    Tests performed on NaS batteries are reported. The results of safety and abuse testing, shock and vibration tests, cell failure on warm-up, freeze thaw, overtemperature conditions, electrolyte fracture, overdischarge, and short circuit tests are presented along with GEO and LEO cycle tests and the status of the NaS cell flight tests.

  11. 49 CFR 40.187 - What does the MRO do with split specimen laboratory results?

    2010-10-01

    ...(s) were not detected; adulteration criteria were not met; and/or substitution criteria were not met... adulteration and/or substitution, as appropriate. (iii) If you determine that there is a legitimate medical... adulteration and/or substitution finding of the split specimen, as the MRO you must report the result as...

  12. An Infrared Laboratory for the Study of Planetary Materials (IRIS): First Results of Impact Rock Studies

    Morlok, A.; Ahmedi, M.; Hiesinger, H.

    2013-09-01

    We present the results of a study about the mid-infrared reflect ance properties of impact rocks from the zördlinger Ries impact crater. Spectra from separated components of suevite, melt glass, devitrified glass and matrix show a high degree of similarity, reflecting the high abundance of amorphous materials.

  13. Genetic Variation on 9p22 Is Associated with Abnormal Ovarian Ultrasound Results in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

    Wentzensen, Nicolas; Black, Amanda; Jacobs, Kevin; Yang, Hannah P.; Berg, Christine D.; Caporaso, Neil; Peters, Ulrike; Ragard, Lawrence; Buys, Saundra S.; Chanock, Stephen; Hartge, Patricia

    2011-01-01

    Background A recent ovarian cancer genome-wide association study (GWAS) identified a locus on 9p22 associated with reduced ovarian cancer risk. The single nucleotide polymorphism (SNP) markers localize to the BNC2 gene, which has been associated with ovarian development. Methods We analyzed the association of 9p22 SNPs with transvaginal ultrasound (TVU) screening results and CA-125 blood levels from participants without ovarian cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Scre...

  14. Enhancements in Glovebox Design Resulting from Laboratory-Conducted FIre Tests

    Brooks, Kriston P.; Wunderlich, Gregory M.; Mcentire, James R.; Richmond, William G.

    2013-06-14

    The primary mission of the Pit Disassembly and Conversion Facility (PDCF) Project was to disassemble nuclear weapons pits and convert the resulting special nuclear materials to a form suitable for further disposition. Because of the nature of materials involved, the fundamental system which allowed PDCF to perform its mission was a series of integrated and interconnected gloveboxes which provided confinement and containment of the radioactive materials being processed. The high throughput planned for PDCF and the relatively high neutron and gamma radiation levels of the pits required that gloveboxes be shielded to meet worker dose limits. The glovebox shielding material was required to contain high hydrogen concentrations which typically result in these materials being combustible. High combustible loadings created design challenges for the facility fire suppression and ventilation system design. Combustible loading estimates for the PDCF Plutonium (Pu) Processing Building increased significantly due to these shielding requirements. As a result, the estimates of combustible loading substantially exceeded values used to support fire and facility safety analyses. To ensure a valid basis for combustible loading contributed by the glovebox system, the PDCF Project funded a series of fire tests conducted by the Southwest Research Institute on door panels and a representative glovebox containing Water Extended Polyester (WEP) radiological shielding to observe their behavior during a fire event. Improvements to PDCF glovebox designs were implemented based on lessons learned during the fire test. In particular, methods were developed to provide high levels of neutron shielding while maintaining combustible loading in the glovebox shells at low levels. Additionally, the fire test results led to design modifications to mitigate pressure increases observed during the fire test in order to maintain the integrity of the WEP cladding. These changes resulted in significantly

  15. Field and laboratory testing for amitraz-tolerant varroa populations. How comparable are their results?

    Pires, Sância; Pereira, Óscar; Murilhas, António

    2007-01-01

    Portuguese beekeepers have frequently used amitraz (Apivar, Acadrex) in an attempt to cope with Varroa. As a result of beekeepers’ claims of an alarming decrease in amitraz field treatment efficacy, a nation-wide screening project was launched to ascertain the merit of those claims and, eventually, introduce changes in the way state institutions were interacting with beekeeping associations and beekeepers. Approximately 4.000 colonies were field-tested (following a similar approach to the ...

  16. Deletion of collapsin response mediator protein 4 results in abnormal layer thickness and elongation of mitral cell apical dendrites in the neonatal olfactory bulb.

    Tsutiya, Atsuhiro; Watanabe, Hikaru; Nakano, Yui; Nishihara, Masugi; Goshima, Yoshio; Ohtani-Kaneko, Ritsuko

    2016-05-01

    Collapsin response mediator protein 4 (CRMP4), a member of the CRMP family, is involved in the pathogenesis of neurodevelopmental disorders such as schizophrenia and autism. Here, we first compared layer thickness of the olfactory bulb between wild-type (WT) and CRMP4-knockout (KO) mice. The mitral cell layer (MCL) was significantly thinner, whereas the external plexiform layer (EPL) was significantly thicker in CRMP4-KO mice at postnatal day 0 (PD0) compared with WTs. However, differences in layer thickness disappeared by PD14. No apoptotic cells were found in the MCL, and the number of mitral cells (MCs) identified with a specific marker (i.e. Tbx21 antibody) did not change in CRMP4-KO neonates. However, DiI-tracing showed that the length of mitral cell apical dendrites was greater in CRMP4-KO neonates than in WTs. In addition, expression of CRMP4 mRNA in WT mice was most abundant in the MCL at PD0 and decreased afterward. These results suggest that CRMP4 contributes to dendritic elongation. Our in vitro studies showed that deletion or knockdown of CRMP4 resulted in enhanced growth of MAP2-positive neurites, whereas overexpression of CRMP4 reduced their growth, suggesting a new role for CRMP4 as a suppressor of dendritic elongation. Overall, our data suggest that disruption of CRMP4 produces a temporary alteration in EPL thickness, which is constituted mainly of mitral cell apical dendrites, through the enhanced growth of these dendrites. PMID:26739921

  17. Stiffness modulus of Polyethylene Terephthalate modified asphalt mixture: A statistical analysis of the laboratory testing results

    Highlights: • Effect of PET modification on stiffness property of asphalt mixture was examined. • Different temperatures and loading amounts were designated. • Statistical analysis was used to find interactions between selected variables. • A good agreement between experimental results and predicted values was obtained. • Optimal amount of PET was calculated to achieve the highest mixture performance. - Abstract: Stiffness of asphalt mixture is a fundamental design parameter of flexible pavement. According to literature, stiffness value is very susceptible to environmental and loading conditions. In this paper, effects of applied stress and temperature on the stiffness modulus of unmodified and Polyethylene Terephthalate (PET) modified asphalt mixtures were evaluated using Response Surface Methodology (RSM). A quadratic model was successfully fitted to the experimental data. Based on the results achieved in this study, the temperature variation had the highest impact on the mixture’s stiffness. Besides, PET content and amount of stress showed to have almost the same effect on the stiffness of mixtures. The optimal amount of PET was found to be 0.41% by weight of aggregate particles to reach the highest stiffness value

  18. Chromosomal Abnormalities in ADHD

    J Gordon Millichap

    2002-07-01

    Full Text Available The prevalence of fragile X syndrome, velocardiofacial syndrome (VCFS, and other cytogenetic abnormalities among 100 children (64 boys with combined type ADHD and normal intelligence was assessed at the NIMH and Georgetown University Medical Center.

  19. Chromosomal abnormalities and autism

    Farida El-Baz

    2016-01-01

    Conclusion: Chromosomal abnormalities were not detected in the studied autistic children, and so the relation between the genetics and autism still needs further work up with different study methods and techniques.

  20. Attentive, Affective, and Adaptive Behavior in the Cat: Sensory deprivation of the forebrain by lesions in the brain stem results in striking behavioral abnormalities.

    Sprague, J M; Chambers, W W; Stellar, E

    1961-01-20

    Lesions of the lateral portion of the upper midbrain, involving medial, lateral, spinal, and trigeminal lemnisci primarily, result in a consistent syndrome of symptoms in the cat. (i) There is a marked sensory deficit, characterized mainly by sensory inattention and poor localization in the tactile, proprioceptive, auditory, gustatory, and nociceptive modalities, where direct pathways are interrupted. Similar defectsappear in vision and olfaction where no known direct or primary paths are interrupted. (ii) These cats are characterized by a lack of affect, showing little or no defensive and aggressive reaction to noxious and aversive situations and no response to pleasurable stimulation or solicitation of affection or petting. The animals are mute, lack facial expression, and show minimal autonomic responses. (iii) They show a hyperexploratory activity characterized by incessant, stereotyped wandering, sniffing, and visual searching, as though hallucinating. This behavior appears to be centrally directed and is very difficult to interrupt with environmental stimuli. (iv) They also demonstrate exaggerated oral activities: they snap in response to tactile stimulation of the lips, seizing and swallowing small objects even if inedible; they overeat; they hold objects too large to swallow (a mouse, a catnip ball) firmly clamped in the mouth for long periods of time; they mount and seize other animals (rat, cat, dog, monkey) by the back or the neck; they lick and chew the hair and skin of the back or tail incessantly when confined in a cage. In interpreting these results we emphasize the view that the syndrome is due chiefly to the extensive, specific, sensory deprivation produced by interruption of the lemnisci at the rostral midbrain. The relation of these findings to the effects of sensory isolation in man and animals, to the effects of midbrain lesions and neodecortication, to parietal lobe syndrome in primates, and to the behavior of autistic children is discussed

  1. Installation and test results of a high-power, CW klystrode amplifier at Los Alamos National Laboratory

    The Chalk River Laboratory (CRL) 1.25 MeV, 267 MHz CW radio frequency quadrupole (RFQ) project has been moved to Los Alamos AOT Division as a collaborative effort between Los Alamos and Chalk River Laboratories. The RF part of this project includes two 267 MHz, 0.25 MW, CW klystrode transmitters. The klystrode is a relatively new type of RF source that combines the input structure from a conventional gridded tube and the output structure of a klystron. It is widely used within the UHF television band at reduced power (60 kW at peak of sync). However, this is the first application of a high power klystrode for a particle accelerator. This paper will describe the experimental configuration at Los Alamos, provide block diagrams of the klystrode transmitter, discuss the attributes of the klystrode which make it a desirable candidate for high efficiency CW accelerators, and present relevant test results

  2. Results of the radiological survey at the ALCOA Research Laboratory, 600 Freeport Road, New Kensington, Pennsylvania (ANK001)

    At the request of the US Department of Energy (DOE), a team from Oak Ridge National Laboratory conducted a radiological survey at the ALCOA Research Laboratory, 600 Freeport Road, New Kensington, Pennsylvania. The survey was performed on November 12, 1991. The purpose of the survey was to determine whether the property was contaminated with radioactive residues, principally 238U, as a result of work done for the Manhattan Engineer District in 1944. The survey included measurement of direct alpha and beta-gamma levels in the northeast comer of the basement of Building 29, and the collection of a debris sample from a floor drain for radionuclide analysis. The survey area was used for experimental canning of uranium slugs prior to production activities at the former New Kensington Works nearby

  3. Clinical results of stereotactic helium-ion radiosurgery of the pituitary gland at Lawrence Berkeley Laboratory

    Levy, R.P.; Fabrikant, J.I.; Lyman, J.T.; Frankel, K.A.; Phillips, M.H.; Lawrence, J.H.; Tobias, C.A.

    1989-12-01

    The first therapeutic clinical trial using accelerated heavy-charged particles in humans was performed for the treatment of various endocrine and metabolic disorders of the pituitary gland, and as suppressive therapy for adenohypophyseal hormone-responsive carcinomas and diabetic retinopathy. Since then, over 800 patients have received stereotactically-directed plateau-beam heavy-charged particle pituitary irradiation at this institution. In acromegaly, Cushing's disease, Nelson's syndrome and prolactin-secreting tumors, the therapeutic goal in the 433 patients treated has been to destroy or inhibit the growth of the pituitary tumor and control hormonal hypersecretion, while preserving a functional rim of tissue with normal hormone-secreting capacity, and minimizing neurologic injury. An additional group of 34 patients was treated for nonsecreting chromophobe adenomas. This paper discusses the methods and results of these treatments. 11 refs.

  4. SALT segmented primary mirror: laboratory test results for FOGALE inductive edge sensors

    Menzies, John; Gajjar, Hitesh; Buous, Sébastien; Buckley, David; Gillingham, Peter

    2010-07-01

    At the Southern African Large Telescope (SALT), in collaboration with FOGALE Nanotech, we have been testing the recently-developed new generation inductive edge sensors. The Fogale inductive sensor is one technology being evaluated as a possible replacement for the now defunct capacitance-based edge sensing system. We present the results of exhaustive environmental testing of two variants of the inductive sensor. In addition to the environmental testing including RH and temperature cycles, the sensor was tested for sensitivity to dust and metals. We also consider long-term sensor stability, as well as that of the electronics and of the glue used to bond the sensor to its supporting structure. A prototype design for an adjustable mount is presented which will allow for in-plane gap and shear variations present in the primary mirror configuration without adversely disturbing the figure of the individual mirror segments or the measurement accuracy.

  5. Clinical results of stereotactic helium-ion radiosurgery of the pituitary gland at Lawrence Berkeley Laboratory

    The first therapeutic clinical trial using accelerated heavy-charged particles in humans was performed for the treatment of various endocrine and metabolic disorders of the pituitary gland, and as suppressive therapy for adenohypophyseal hormone-responsive carcinomas and diabetic retinopathy. Since then, over 800 patients have received stereotactically-directed plateau-beam heavy-charged particle pituitary irradiation at this institution. In acromegaly, Cushing's disease, Nelson's syndrome and prolactin-secreting tumors, the therapeutic goal in the 433 patients treated has been to destroy or inhibit the growth of the pituitary tumor and control hormonal hypersecretion, while preserving a functional rim of tissue with normal hormone-secreting capacity, and minimizing neurologic injury. An additional group of 34 patients was treated for nonsecreting chromophobe adenomas. This paper discusses the methods and results of these treatments. 11 refs

  6. Description of buffer tests in 2005 - 2007. Results of laboratory tests

    The horizontal design for the deposition of nuclear waste in granitic rock has been ongoing since 2002. Clay Technology has contributed with studies that mainly concern the behaviour and design of the bentonite buffer material. The work described in this report was a part of the design subproject and was conducted from 2005 up to mid-2007. The results of the work and the increased general understanding of the behaviour of the buffer in KBS-3H have led to two main designs. BD (Basic Design) and DAWE (Drainage Artificial Watering and air Evacuation). Several significant uncertainties related to the behaviour of distance blocks and buffer materials were identified. The most important issues to be resolved were included in an extensive buffer test plan and this report presents the work carried. The critical issues (an issue is defined as critical if there is clear uncertainty in fulfilling the design basis) to be resolved to produce viable designs were: 1. Humidity-induced swelling. This process may cause cracking and subsequent loss of bentonite as the debris falls on to the floor. There is also the possibility that the blocks could swell and come into contact with the rock wall. Both these processes will lead to a hindering of the free water flow on the tunnel floor in DAWE and may subsequently result in the erosion of bentonite material from the tunnel. This is not expected to be an issue in the BD owing to the small buffer-rock gap engineered into the design. 2. Erosion of of filling blocks and buffer. This process will lead either to a loss of material from the emplacement drift if it takes place before a hydraulic plug is built or to redistribution of bentonite in the emplacement drift if it takes place afterwards. Localized erosion may be harmful for both design alternatives if it results in a substantial loss or redistribution of material. 3. Artificial wetting of distance blocks. Both design alternatives include artificial water filling of the gap between the

  7. Description of buffer tests in 2005 - 2007. Results of laboratory tests

    Sanden, Torbjoern; Boergesson, Lennart; Dueck, Ann; Goudarzi, Reza; Loennqvist, Margareta; Nilsson, Ulf; Aakesson, Mattias (Clay Technology AB, Lund (Sweden))

    2008-12-15

    The horizontal design for the deposition of nuclear waste in granitic rock has been ongoing since 2002. Clay Technology has contributed with studies that mainly concern the behaviour and design of the bentonite buffer material. The work described in this report was a part of the design subproject and was conducted from 2005 up to mid-2007. The results of the work and the increased general understanding of the behaviour of the buffer in KBS-3H have led to two main designs. BD (Basic Design) and DAWE (Drainage Artificial Watering and air Evacuation). Several significant uncertainties related to the behaviour of distance blocks and buffer materials were identified. The most important issues to be resolved were included in an extensive buffer test plan and this report presents the work carried. The critical issues (an issue is defined as critical if there is clear uncertainty in fulfilling the design basis) to be resolved to produce viable designs were: 1. Humidity-induced swelling. This process may cause cracking and subsequent loss of bentonite as the debris falls on to the floor. There is also the possibility that the blocks could swell and come into contact with the rock wall. Both these processes will lead to a hindering of the free water flow on the tunnel floor in DAWE and may subsequently result in the erosion of bentonite material from the tunnel. This is not expected to be an issue in the BD owing to the small buffer-rock gap engineered into the design. 2. Erosion of of filling blocks and buffer. This process will lead either to a loss of material from the emplacement drift if it takes place before a hydraulic plug is built or to redistribution of bentonite in the emplacement drift if it takes place afterwards. Localized erosion may be harmful for both design alternatives if it results in a substantial loss or redistribution of material. 3. Artificial wetting of distance blocks. Both design alternatives include artificial water filling of the gap between the

  8. Report of the research results with University of Tokyo, Nuclear Engineering Research Laboratory's Facilities in fiscal 1989

    This is the report of the results of research carried out by the common utilization of the reactor 'Yayoi' and an electron accelerator in the Nuclear Engineering Research Laboratory in fiscal year 1989. In fiscal year 1989, the research themes using the reactor Yayoi or related to it were 15, and those using the linear accelerator reached 12, thus the common utilization attracted the strong interest of users. The Yayoi has been operated satisfactorily without trouble. The results of the research carried out by the common utilization of the Yayoi and a linac and the reports of 12 Yayoi research meetings in fiscal year 1989 are collected. (J.P.N.)

  9. Preliminary results on the implantation of a laboratory for the measurement of natural radiocarbon

    Though the project 'Amazonia I', activity 'Paleoclimatology', sub-project 'hydrologic cycle', the Centro de Energia Nuclear da Agricultura (CENA) from Universidade de Sao Paulo has received recently, from Atomic Energy International Agency a research apparatus for the tranformation of carbon from benzene samples and a liquid scintillator spectrometer of low background, for the detection of natural radiocarbon. In the production of 3ml of benzene, synthetized from oxalic acid P.A. and calcium carbonate P.A., it was obtained a performance of more than 80%; preliminary results were also obtained for shell and coal samples. For the detection of radiocarbon, after optimization of the spectral region, and selection of samples, it was seen that the efficiency of the spectrometer was of the order of 55%, with a base counting rate of 1,3 cmp. The age limit, under the actual operation conditions was 41.600 years 95% (2σ) and 36.700 years for 99% (3σ) considering a time counting of 1000 minutes for the sample and the bacground radiation. (A.C.A.S.)

  10. Laboratory and testbeam results for thin and epitaxial planar sensors for HL-LHC

    The High-Luminosity LHC (HL-LHC) upgrade of the CMS pixel detector will require the development of novel pixel sensors which can withstand the increase in instantaneous luminosity to L=5×1034 cm−2s−1 and collect ∼ 3000 fb−1 of data. The innermost layer of the pixel detector will be exposed to doses of about 1016 neq/ cm2. Hence, new pixel sensors with improved radiation hardness need to be investigated. A variety of silicon materials (Float-zone, Magnetic Czochralski and Epitaxially grown silicon), with thicknesses from 50 μm to 320 μm in p-type and n-type substrates have been fabricated using single-sided processing. The effect of reducing the sensor active thickness to improve radiation hardness by using various techniques (deep diffusion, wafer thinning, or growing epitaxial silicon on a handle wafer) has been studied. The results for electrical characterization, charge collection efficiency, and position resolution of various n-on-p pixel sensors with different substrates and different pixel geometries (different bias dot gaps and pixel implant sizes) will be presented

  11. APIC: Absolute Position Interfero Coronagraph for direct exoplanet detection: first laboratory results

    Allouche, Fatmé; Glindemann, Andreas; Aristidi, Eric; Vakili, Farrokh

    2010-07-01

    For the detection and direct imaging of exoplanets, when the intensity ratio between a star and its orbiting planet can largely exceed 106, coronagraphic methods are mandatory. In 1996, a concept of achromatic interferocoronagraph (AIC) was presented by J. Gay and Y. Rabbia for the detection of very faint stellar companions, such as exoplanets. In an earlier paper, we presented a modified version of the AIC permitting to determine the relative position of these faint companions with respect to the parent star, a problem unsolved in the original design of the AIC. Our modification lied in the use of cylindrical lens doublets as field rotator. By placing two of them in one arm of the interferometric set-up of AIC, we destroyed the axis of symmetry induced by the AIC's original design. Our theoretical study, along with the numerical computations, presented then, and the preliminary test bench results aiming at validating the cylindrical lens doublet field rotation capability, presented in this paper, show that the axis of symmetry is destroyed when one of the cylindrical doublets is rotated around the optic axis.

  12. Targeted mutations in the Na,K-ATPase α 2 isoform confer ouabain resistance and result in abnormal behavior in mice.

    Schaefer, Tori L; Lingrel, Jerry B; Moseley, Amy E; Vorhees, Charles V; Williams, Michael T

    2011-06-01

    Sodium and potassium-activated adenosine triphosphatases (Na,K-ATPase) are ubiquitous, participate in osmotic balance and membrane potential, and are composed of α, β, and γ subunits. The α subunit is required for the catalytic and transport properties of the enzyme and contains binding sites for cations, ATP, and digitalis-like compounds including ouabain. There are four known α isoforms; three that are expressed in the CNS in a regional and cell-specific manner. The α2 isoform is most commonly found in astrocytes, pyramidal cells of the hippocampus in adults, and developmentally in several other neuronal types. Ouabain-like compounds are thought to be produced endogenously in mammals, bind the Na,K-ATPase, and function as a stress-related hormone, however, the impact of the Na,K-ATPase ouabain binding site on neurobehavioral function is largely unknown. To determine if the ouabain binding site of the α2 isoform plays a physiological role in CNS function, we examined knock-in mice in which the normally ouabain-sensitive α2 isoform was made resistant (α2(R/R) ) while still retaining basal Na,K-ATPase enzymatic function. Egocentric learning (Cincinnati water maze) was impaired in adult α2(R/R) mice compared to wild type (WT) mice. They also exhibited decreased locomotor activity in a novel environment and increased responsiveness to a challenge with an indirect sympathomimetic agonist (methamphetamine) relative to WT mice. The α2(R/R) mice also demonstrated a blunted acoustic startle reflex and a failure to habituate to repeated acoustic stimuli. The α2(R/R) mice showed no evidence of altered anxiety (elevated zero maze) nor were they impaired in spatial learning or memory in the Morris water maze and neither group could learn in a large Morris maze. These results suggest that the ouabain binding site is involved in specific types of learning and the modulation of dopamine-mediated locomotor behavior. PMID:20936682

  13. Quality assurance of deuterium and oxygen-18 results using EQ-device at Lageo Stable Isotope Laboratory

    Lageo Stable Isotope Laboratory started in 1996 with the support of the International Atomic Energy Agency. It is equipped with a Finnigan Delta-S mass spectrometer and an equilibration unit for sample preparation. 4 ml of sample is used to perform both deuterium and oxygen-18 isotope analysis through equilibration with a reference gas. This implies that settings for ion source in the mass spectrometer must apply for both isotopes and is constantly verified via Isodat. Being a regional laboratory for analysis of both deuterium and oxygen-18, it is mandatory for the Lageo Stable Isotope Laboratory to report high quality results. In this sense, there is a procedure with many points of control in order to get the best results. Among these is humidity in the analyser system: A sequence is only started if the level of mass 18 (H2O)in cup 2 is below 0.5 because it was discovered that level greater than 0.5 gives poor reproducibility. Environment: An air condition system is set at 20 deg C and the moisture removed with the help of dehumidifiers. Changes in the room temperature negatively affect the stability of the system and thus reproducibility of analyses. Stability during the sequence: if the difference of the same lab. standard between first and the last positions is more than 0.6 the whole batch is rejected. It is guaranteed that the values do not change considerably in the sequence which takes nearly 5 hours. Reproducibility: If above mentioned control points are fulfilled, samples are measured again using different aliquots, bottles and Pt-sticks at different date. If difference between D-values (against V-SMOW) is less than 1.2 per mille for Deuterium and 0.1 per mille for Oxygen-18, results are accepted. In practice, differences are lying around 1.0 and 0.06 per mille respectively. Accuracy: a control sample (calibrated against V-SMOW) is included in the sequence at least once per week in order to observe the accuracy of the results. Also, internal standards

  14. Analysis of environmental contamination resulting from catastrophic incidents: part 1. Building and sustaining capacity in laboratory networks.

    Magnuson, Matthew; Ernst, Hiba; Griggs, John; Fitz-James, Schatzi; Mapp, Latisha; Mullins, Marissa; Nichols, Tonya; Shah, Sanjiv; Smith, Terry; Hedrick, Elizabeth

    2014-11-01

    Catastrophic incidents, such as natural disasters, terrorist attacks, and industrial accidents, can occur suddenly and have high impact. However, they often occur at such a low frequency and in unpredictable locations that planning for the management of the consequences of a catastrophe can be difficult. For those catastrophes that result in the release of contaminants, the ability to analyze environmental samples is critical and contributes to the resilience of affected communities. Analyses of environmental samples are needed to make appropriate decisions about the course of action to restore the area affected by the contamination. Environmental samples range from soil, water, and air to vegetation, building materials, and debris. In addition, processes used to decontaminate any of these matrices may also generate wastewater and other materials that require analyses to determine the best course for proper disposal. This paper summarizes activities and programs the United States Environmental Protection Agency (USEPA) has implemented to ensure capability and capacity for the analysis of contaminated environmental samples following catastrophic incidents. USEPA's focus has been on building capability for a wide variety of contaminant classes and on ensuring national laboratory capacity for potential surges in the numbers of samples that could quickly exhaust the resources of local communities. USEPA's efforts have been designed to ensure a strong and resilient laboratory infrastructure in the United States to support communities as they respond to contamination incidents of any magnitude. The efforts include not only addressing technical issues related to the best-available methods for chemical, biological, and radiological contaminants, but also include addressing the challenges of coordination and administration of an efficient and effective response. Laboratory networks designed for responding to large scale contamination incidents can be sustained by applying

  15. An Abnormal Vibrational Mode of Torsion Pendulum

    赵亮; 涂英; 顾邦明; 胡忠坤; 罗俊

    2003-01-01

    In the experiment for the determination of the gravitational constant G, we found an abnormal vibrational mode of the torsion pendulum. The abnormal mode disappeared as a magnetic damper was introduced to the torsion pendulum system. Our experimental results also show that the magnetic damper can be used to suppress the high frequency vibrational noises to torsion pendulums effectively.

  16. Sandia National Laboratories results for the 2010 criticality accident dosimetry exercise, at the CALIBAN reactor, CEA Valduc France.

    Ward, Dann C.

    2011-09-01

    This document describes the personal nuclear accident dosimeter (PNAD) used by Sandia National Laboratories (SNL) and presents PNAD dosimetry results obtained during the Nuclear Accident Dosimeter Intercomparison Study held 20-23 September, 2010, at CEA Valduc, France. SNL PNADs were exposed in two separate irradiations from the CALIBAN reactor. Biases for reported neutron doses ranged from -15% to +0.4% with an average bias of -7.7%. PNADs were also exposed on the back side of phantoms to assess orientation effects.

  17. Report of the research results with University of Tokyo, Nuclear Engineering Research laboratory's Facilities in fiscal 1992

    This publication summarizes the results of the joint utilization of the research 'Yayoi' and the electron beam accelerator in the Nuclear Engineering Research Laboratory, University of Tokyo, in the fiscal year 1992. The Yayoi was operated smoothly through the year, and the number of research themes, for which the reactor Yayoi was jointly utilized and the related themes reached 23 cases. The research themes of the linac count up to 17, after its reconstruction to be twin-linac. In this publication, in addition to the utilization reports, also the 16 reports of Yayoi Study Meetings held in fiscal year 1992 are collected. (J.P.N.)

  18. Microbial Growth and Air Pollutants in the Corrosion of Carbonate Rocks: Results from Laboratory and Outdoor Experimental Tests

    Moroni, B.; Poli, G.; Pitzurra, L.

    2003-04-01

    Microorganisms and atmospheric pollution are primary causes of deterioration of materials exposed to open air. Due to the variety of chemical-mineralogical compositions and textures, stone represents a variegated substrate that interacts with environmental fluids and particulate, and is a selective environment for biological proliferation. Carbonate rocks, in particular, are highly exposed to environmental decay and extremely susceptible to acid attack caused by atmospheric pollutants and metabolic acid production. The aim of this work is to study the combined effect of microbial contamination and atmospheric pollutants in the weathering of carbonate rocks by means of laboratory and outdoor exposure tests. Laboratory experiments performed on carbonate rocks allowed evaluation of the influence of the gas mixture in the chemical modifications of the lithic substrate, and formulation of a kinetic model of sulphation. The obtained results suggest that nucleation alternates with growth as leading processes in the development of sulphation. In particular, nucleation of the reaction products is the leading process in the initial period of sulphation, which is characterized by a marked slowdown of the reaction progress, whereas growth of the products is the leading process in the subsequent period of resumption of sulphation. In situ experiments performed by exposing limestone specimens at two air monitoring stations in Perugia with different degrees of urban air pollution showed high levels of fungal colonization at early times and the presence of weathering products (i.e. gypsum) in the longer term. Results point to a combined effect of microbial colonization and atmospheric pollutants in promoting the weathering of stone through acid attack within the film of water present on the surface of the exposed material, and through the oxidation of metal sulphide particulate pollutant to sulphate. Laboratory tests assaying the extent of fungal colonization and/or chemical

  19. Neurological abnormalities predict disability

    Poggesi, Anna; Gouw, Alida; van der Flier, Wiesje;

    2014-01-01

    To investigate the role of neurological abnormalities and magnetic resonance imaging (MRI) lesions in predicting global functional decline in a cohort of initially independent-living elderly subjects. The Leukoaraiosis And DISability (LADIS) Study, involving 11 European centres, was primarily aimed...... at evaluating age-related white matter changes (ARWMC) as an independent predictor of the transition to disability (according to Instrumental Activities of Daily Living scale) or death in independent elderly subjects that were followed up for 3 years. At baseline, a standardized neurological examination...... abnormality independently predicted transition to disability or death [HR (95 % CI) 1.53 (1.01-2.34)]. The hazard increased with increasing number of abnormalities. Among MRI lesions, only ARWMC of severe grade independently predicted disability or death [HR (95 % CI) 2.18 (1.37-3.48)]. In our cohort...

  20. Effects of abnormal results of simple glucose screening test on pregnancy%单纯葡萄糖筛查试验异常对妊娠的影响

    甘嫦勋; 蔡鹏宇; 吴淑芳; 黎美金; 吴怡萍; 钟金华

    2012-01-01

    Objective: To explore the effects of abnormal results of simple glucose screening test on pregnancy. Methods: The data of 2 473 pregnant women who gave birth to their babies in the hospital from January 2007 to June 2010 were analyzed retrospectively, 628 pregnant women with abnormal results of simple glucose screening test and normal results of oral glucose tolerance test ( OGTT) were selected as abnormal group, 1 845 pregnant women with normal results of simple glucose screening test were selected as control group. The gestation-al weeks at delivery, amniotic fluid index detected by ultrasonography before rupture of fetal membrane, birth weight, body height, and head circumference of neonates in the two groups were recorded; the incidences of polyhydramnios, premature delivery, macrosomia, fetal growth restriction, birth weight, body height, and head circumference of neonates in the two groups were compared. Results: The incidence of fetal growth restriction, birth weight, and head circumference of neonates in abnormal group were 2. 5% , (50. 8 ± 1. 4) cm, and (34. 2 ± 1. 5) cm, respectively; the incidence of fetal growth restriction, birth weight, and head circumference of neonates in normal group were 2, 9% , (50. 7 ± 1. 5) cm, and (34. 1 ± 1. 4) cm, respectively, there was no statistically significant difference between the two groups. The incidences of polyhydramnios, premature delivery, macrosomia, fetal growth restriction, and birth weight in abnormal group were 3.3%, 5.3%, 11.5% , and (3. 5 ±0.5) kg; the incidences of polyhydramnios , premature delivery, macrosomia, fetal growth restriction, and birth weight in normal group were 0. 6% , 2. 5% , 4. 7% , and (3. 2 ±0. 6) kg, there was statistically significant difference between the two groups. Conclusion: The incidences of polyhydramnios, premature delivery, macrosomia, fetal growth restriction, and birth weight of neonates in the patients with abnormal results of simple glucose screening test were

  1. REFLECTANCE ANISOTROPY MEASUREMENTS USING A PUSHBROOM SPECTROMETER MOUNTED ON UAV AND A LABORATORY GONIOMETER – PRELIMINARY RESULTS

    J. Suomalainen

    2015-08-01

    Full Text Available During 2014–2015 we have developed a new method to measure reflectance factor anisotropy using a pushbroom spectrometer mounted on a multicopter UAV. In this paper/presentation we describe the acquisition method and show the preliminary results of the experiment. To validate the measurements the same targets have also been measured with a laboratory goniometer system. The first experiments over sugar beet fields in 2014 show similar trends in both UAV and laboratory anisotropy data, but also some differences caused by differences in sampling and diffuse illumination. In 2015 a more extensive study on wheat, barley and potato fields were performed. The measurements were repeated on three days over the growth of the crops allowing linking the development of the crops to the anisotropy signals. On each day the anisotropy measurement was repeated 4–5 times with different solar zenith angles ranging from 60° to 40° allowing analysis how the solar angle affects the anisotropy. The first results of these experiments will be presented in this conference.

  2. Is Dark Energy Abnormally Weighting?

    Fuzfa, A.; Alimi, J. -M.

    2006-01-01

    We present a new interpretation of dark energy in terms of an \\textit{Abnormally Weighting Energy} (AWE). This means that dark energy does not couple to gravitation in the same way as ordinary matter, yielding a violation of the weak and strong equivalence principles on cosmological scales. The resulting cosmological mechanism accounts for the Hubble diagram of type Ia supernovae in terms of both cosmic acceleration and variation of the gravitational constant while still accounting for the pr...

  3. Evaluation of Outcome- Prenatal Diagnosis Indication and Results Suitability in Families Referred to our Laboratory For Prenatal Diagnosis

    Ayşegül Türkyılmaz

    2007-01-01

    Full Text Available Since our aim is to establish the importance, necessity and concept of prenatal diagnosis in our region and supply routine service at a stage which we admit as a transitional period for application, all of the materials of amniocentesis, cordocentesis and corion villi sample referred to laboratories were evaluated without refusal.When we examined prenatal diagnoses of these specimens, we found Down Risk (according to triple test result in 164 specimens (%34, fetal anomaly risk in 122 (%25, advanced age in 69 (%14 poor-obstetric anamnesis in 27(%5, Down Syndrome- infant history in 20 (%4, family request in 17, and habitual abortus (%3 etc. in specimens. Lymphocyte Culture prepared in duplicate for each specimen and chromosome were obtained from total of ten slides for each specimen. Slides were stained with Giemsa Banding Technic (GTG Banding. Total (10x481 4810 slides were evaluated for diagnosis.There were no false positive and false negative results.

  4. The use of scientific and technical results from underground research laboratory investigations for the geological disposal of radioactive waste

    The objective of the report is to provide information on the use of results obtained from underground research laboratory investigations for the development of a deep geological repository system for long lived and/or high level radioactive waste including spent fuel. Specifically, it should provide Member States that intend to start development of a geological disposal system with an overview of existing facilities and of the sorts and quality of results that have already been acquired. The report is structured into six main themes: rock characterization methodologies and testing; assessment of the geological barrier; assessment of the engineered barrier system; respository construction techniques; demonstration of repository operations; confidence building and international co-operation

  5. 不育男性Y染色体长度异常的精液质量%Effect of abnormality Y chromosome and sperm quality on the result of insisted reproductive techniques

    谢伟; 秦雯; 莫定敢; 陈美佳; 吕福通; 覃爱平

    2016-01-01

    Objective To investigate the effect of abnormality Y chromosome and sperm quality on the clinical result of insisted reproductive technique (ART). Methods We retrospectively analyzed the effect of ab-normality Y chromosome and sperm quality on embryo quality/result of pregnancy of patients undergoing ART. In-fertile men with normality Y chromosome (n=436) and with abnormality Y chromosome (n =146) from Jan 2010 to Dec 2010 were enrolled in this study. The infertile men were divided into four groups: the normality Y chromo-some plus teratozoospermia group , the normality Y chromosome plus normal sperm quality group , the abnormality Y chromosome plus teratozoospermia group, the abnormality Y chromosome plus normal sperm quality group. Embryo quality and the results of clinic pregnancy outcome were analyzed among the four groups. Results Fertilization rate of the four groups was 73.4%, 69.0%, 70.9% and 68%, respectively (P < 0.05). No significant differences were found in thecleavage rate, optimal embryo rate and pregnancy outcome among the four groups. Conclusions Both abnormality Y chromosome length and teratozoospermia may be affect the fertility rate of the infertile men undergoing IVF/ICSI.%目的:了解在辅助生殖技术(insisted reproductive techniques,ART)中 Y 染色体长度异常患者的精液质量情况,并按不同精液质量分组,讨论其胚胎质量、临床妊娠结局及意义。方法:通过回顾性分析2010年1月1日至2010年12月31日在中心进行辅助生殖助孕的患者共2739周期,染色体检查682例,其中染色体正常436(63.93%),合并畸形精子症196例,染色体长度异常共146例(Y =22,139例;Y =18,7例),占5.33%,合并畸形精子症73例。将患者分为染色体长度正常组和染色体长度异常组,再分精子形态正常组、精子形态异常组2个亚组,共4组,即染色体长度正常且精子形态正常组(组1),染色体长度正

  6. Results of 1995 characterization of Gunite and Associated Tanks at Oak Ridge National Laboratory, Oak Ridge, Tennessee

    This technical memorandum (TM) documents the 1995 characterization of eight underground radioactive waste tanks at Oak Ridge National Laboratory (ORNL). These tanks belong to the Gunite and Associated Tanks (GAAT) operable unit, and the characterization is part of the ongoing GAAT remedial investigation/feasibility study (RI/FS) process. This TM reports both field observations and analytical results; analytical results are also available from the Oak Ridge Environmental Information System (OREIS) data base under the project name GAAT (PROJ-NAME = GAAT). This characterization effort (Phase II) was a follow-up to the open-quotes Phase Iclose quotes sampling campaign reported in Results of Fall 1994 Sampling of Gunite and Associated Tanks at the Oak Ridge National Laboratory, Oak Ridge, Tennessee, ORNL/ER/Sub/87-99053/74, June 1995. The information contained here should be used in conjunction with that in the previous TM. The sampling plan is documented in ORNL Inactive Waste Tanks Sampling and Analysis Plan, ORNL/RAP/LTR-88/24, dated April 1988, as amended by Addendum 1, Revision 2: ORNL Inactive Tanks Sampling and Analysis Plan, DOE/OR/02-1354 ampersand D2, dated February 1995. Field team instructions are found in ORNL RI/FS Project Field Work Guides 01-WG-20, Field Work Guide for Sampling of Gunite and Associated Tanks, and 01-WG-21, Field Work Guide for Tank Characterization System Operations at ORNL. The field effort was conducted under the programmatic and procedural umbrella of the ORNL RI/FS Program, and the analysis was in accordance with ORNL Chemical and Analytical Sciences Division (CASD) procedures. The characterization campaign is intended to provide data for criticality safety, engineering design, and waste management as they apply to the GAAT treatability study and remediation. The Department of Energy (DOE) Carlsbad office was interested in results of this sampling campaign and provided funding for certain additional sample collection and analysis

  7. Results of 1995 characterization of Gunite and Associated Tanks at Oak Ridge National Laboratory, Oak Ridge, Tennessee

    NONE

    1996-02-01

    This technical memorandum (TM) documents the 1995 characterization of eight underground radioactive waste tanks at Oak Ridge National Laboratory (ORNL). These tanks belong to the Gunite and Associated Tanks (GAAT) operable unit, and the characterization is part of the ongoing GAAT remedial investigation/feasibility study (RI/FS) process. This TM reports both field observations and analytical results; analytical results are also available from the Oak Ridge Environmental Information System (OREIS) data base under the project name GAAT (PROJ-NAME = GAAT). This characterization effort (Phase II) was a follow-up to the {open_quotes}Phase I{close_quotes} sampling campaign reported in Results of Fall 1994 Sampling of Gunite and Associated Tanks at the Oak Ridge National Laboratory, Oak Ridge, Tennessee, ORNL/ER/Sub/87-99053/74, June 1995. The information contained here should be used in conjunction with that in the previous TM. The sampling plan is documented in ORNL Inactive Waste Tanks Sampling and Analysis Plan, ORNL/RAP/LTR-88/24, dated April 1988, as amended by Addendum 1, Revision 2: ORNL Inactive Tanks Sampling and Analysis Plan, DOE/OR/02-1354&D2, dated February 1995. Field team instructions are found in ORNL RI/FS Project Field Work Guides 01-WG-20, Field Work Guide for Sampling of Gunite and Associated Tanks, and 01-WG-21, Field Work Guide for Tank Characterization System Operations at ORNL. The field effort was conducted under the programmatic and procedural umbrella of the ORNL RI/FS Program, and the analysis was in accordance with ORNL Chemical and Analytical Sciences Division (CASD) procedures. The characterization campaign is intended to provide data for criticality safety, engineering design, and waste management as they apply to the GAAT treatability study and remediation. The Department of Energy (DOE) Carlsbad office was interested in results of this sampling campaign and provided funding for certain additional sample collection and analysis.

  8. CT of pleural abnormalities

    Briefly discussed were CT diagnosis of pleural thickening, CT technique for examining the pleura or pleuro-pulmonary disease, diagnosis of pleural collections, diagnosis of pleural fluid abnormalities in patients with pneumonia, pleural neoplasms, malignant (diffuse) mesothelioma, metastases, local fibrous tumor of the pleura (benign mesothelioma) (21 refs.)

  9. [Abnormality in bone metabolism after burn].

    Gong, X; Xie, W G

    2016-08-20

    Burn causes bone metabolic abnormality in most cases, including the changes in osteoblasts and osteoclasts, bone mass loss, and bone absorption, which results in decreased bone mineral density. These changes are sustainable for many years after burn and even cause growth retardation in burned children. The mechanisms of bone metabolic abnormality after burn include the increasing glucocorticoids due to stress response, a variety of cytokines and inflammatory medium due to inflammatory response, vitamin D deficiency, hypoparathyroidism, and bone loss due to long-term lying in bed. This article reviews the pathogenesis and regularity of bone metabolic abnormality after burn, the relationship between bone metabolic abnormality and burn area/depth, and the treatment of bone metabolic abnormality, etc. and discusses the research directions in the future. PMID:27562160

  10. A simplified and less expensive strategy for confirming anti HIV-1 screening results in a diagnostic laboratory in Lubumbashi, Zaire.

    Laleman, G; Kambale, M; Van Kerckhoven, I; Kapila, N; Konde, M; Selemani, U; Piot, P; van der Groen, G

    1991-12-01

    The conventional algorithm for HIV testing based on the confirmation of all positive anti-HIV screening reactions by Western blot (WB) is too expensive for developing countries. We investigated the validity of confirming positive screening assay reactions by a second screening test, limiting the use of the supplemental assay to the discrepant test results (algorithm 3), or screening all sera with 2 different assays and retesting all discrepant results by a supplemental assay (algorithm 4) on a panel of 519 sera in a regional reference laboratory in Lubumbashi, Zaire. Combining the Vironostika anti-HTLV-III ELISA with HIV Chek 1 + 2 or Clonatec Rapid HIV 1/2 Ab on all samples and retesting the discrepant results in WB or a line immunoassay (INNO-LIA) (algorithm 4), yielded a sensitivity of 100% and specificities of 98.4% and 99.0% respectively, at costs of 7.3 US $ and 9.3 US $ per test, respectively, for a 40% prevalence of HIV antibody positive samples. The conventional algorithm scored a sensitivity of 97.1% and a specificity of 100% for 11.3 US $ per test. The testing strategy of combining HIV Chek 1 + 2 and Clonatec Rapid HIV 1/2 Ab, an interesting option for small isolated centra, had a 96.6% sensitivity, but yielded only a slightly better specificity of 99.0%, as compared to 97.8% for HIV Chek alone. The price of combining the two simple assays using algorithm 3 was 6.8 US $ per test, using algorithm 4 was 10.6 US $. HIV testing strategies based on ELISA and a simple HIV test are a valuable alternative for reference laboratories faced with a high prevalence of HIV positive samples. PMID:1789703