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Sample records for abbott prism hbsag

  1. 罗氏 Cobas e601与雅培 Architect i2000检测乙肝表面抗原的比较%Comparison of HBsAg Results between Roche Cobas e601 and Abbott Architect i2000 analysis systems

    孙彬; 李康; 吴纯; 郭奉洁; 白光亮; 董梅

    2014-01-01

    目的:比较罗氏电化学发光检测仪Cobas e601与雅培化学发光微粒子免疫分析仪Architect i2000检测乙肝表面抗原的结果。方法选取在雅培 i2000检测仪上检测乙肝表面抗原结果为有反应性,且定量结果小于250 IU/mL 的标本,同时在罗氏 e601进行检测,分析比较检测结果间的差别,并进行直线相关和回归分析。结果共检测46份临床标本,剔除1份两台仪器上检测结果反应性不符的标本外,其余结果具有很好的相关性。其中雅培检测值为0.05~1.00 IU/mL 的15份,两者的直线回归方程为Y =17.49X +0.843,相关系数 r=0.979;1.1~10.00 IU/mL 的15份,两者的直线回归方程为Y =15.72X +21.06,相关系数 r=0.952;11~250 IU/mL 的15份,两者的直线回归方程为Y =29.17X -129,相关系数 r=1.000。结论两种方法的检测结果具有很好的相关性,并可以通过公式进行相互换算。%Objective To compare the difference of the HBsAg detected results between the Roche cobas e601 electrochemilumi-nescence immunoassay instrument and the Abbott Architect i2000chemiluminescent microparticle immunoassay instrument.Methods The HBsAg positive specimens with the quantitation results of lower than 250IU/mL detected by the Abbott Architect i2000 were selected and simultaneously detected by the Roche cobas e601.The differences of detected results were compared and per-formed the linear correlation and analysis regression.Results 46 clinical specimens were detected.The detected results had best correlation between the two instruments by getting rid of 1 specimen with unconformable reactivity of detected results.15 speci-mens had the HBsAg detected result of 0.05-1.00 IU/mL by the Abbott Architect i2000,the linear regression equation was Y =17.49X+0.843(r=0.979);15 specimens had the HBsAg detected result of 1.1 -10.00 IU/mL IU/mL by the Abbott Architect i2000,the linear

  2. Abbott Infant Formula Recall

    U.S. Department of Health & Human Services — This list includes products subject to recall since September 2010 related to infant formula distributed by Abbott. This list will be updated with publicly...

  3. Comparison of serum HBsAg quantitation by four immunoassays, and relationships of HBsAg level with HBV replication and HBV genotypes.

    Edouard Tuaillon

    Full Text Available BACKGROUND: The decline in hepatitis B virus surface antigen (HBsAg may be an early predictor of the viral efficacy of Hepatitis B virus (HBV therapy. The HBsAg levels obtained by different immunoassays now need comparing and the relationships between levels of HBsAg and HBV DNA alongside HBsAg and genotype must be evaluated. METHODOLOGY/PRINCIPAL FINDINGS: HBsAg levels were compared among 80 patients using the Abbott Architect assay, a commercial immunoassay approved for HBsAg detection and quantitation, and three other assays derived from immunoassays approved for HBsAg detection (manufactured by Diasorin, Bio-Rad and Roche. Good correlation was found between the Abbot vs. Diasorin, Bio-Rad and Roche assays with narrow 95% limits of agreement and small mean differences: -0.06 to 0.11, -0.09 log(10 IU/mL; -0.57 to 0.64, -0.04 log(10 IU/mL; -0.09 to 0.45, -0.27 log(10 IU/mL, respectively. These agreements were not affected by genotypes A or D. HBsAg was weakly correlated with HBV DNA, whatever the HBsAg assay used: Abbott, ρ = 0.36 p = 0.001, Diasorin ρ = 0.34, p = 0.002; Bio-Rad ρ = 0.37, p<0.001; or Roche ρ = 0.41, p<0.001. This relationship between levels of HBsAg and HBV DNA seemed to depend on genotypes. Whereas HBsAg (Abbott assay tended to correlate with HBV DNA for genotype A (ρ = 0.44, p = 0.02, no such correlation was significant for genotypes D (ρ = 0.29, p = 0.15. CONCLUSION/SIGNIFICANCE: The quantitation of HBsAg in routine clinical samples is comparable between the reference assay and the adapted assays with acceptable accuracy limits, low levels of variability and minimum discrepancy. While HBsAg quantitation is not affected by HBV genotype, the observed association between levels of HBsAg and HBV DNA seems genotype dependent.

  4. Discordant diagnostic results due to a hepatitis B virus T123A HBsAg mutant.

    Osiowy, Carla; Kowalec, Kaarina; Giles, Elizabeth

    2016-07-01

    HBsAg immunoassay results are occasionally discordant among primary and confirmatory assays or with respect to other markers of HBV infection. Such discordance has been observed repeatedly in Canada with samples having a mutation at HBsAg codon 123 (sT123A). Detection of recombinant expressed HBsAg protein having either sT123 or sA123 was evaluated with one manual and six automated HBsAg immunoassays. The recombinant mutant HBsAg was non-reactive by Abbott AxSYM, while the Abbott ARCHITECT Quantitative and Qualitative II, ADVIA Centaur, and VITROS ECi detection signal was reduced compared with the wild-type protein, approaching the assay cut-off for certain assays, dependent upon the level of protein. The Roche Elecsys and manual immunoassays detected both wild-type and mutant proteins comparatively. The sT123A mutation leads to loss of detection by immunoassays commonly used in Canadian diagnostic laboratories, which may produce misleading results and diagnoses. PMID:27133305

  5. FDA Abbott Infant Formula Recall

    U.S. Department of Health & Human Services — On September 22, 2010, Abbott issued a voluntary recall of certain Similac powdered infant formula after identifying a common warehouse beetle (both larvae and...

  6. Technology evaluation: ABT-510, Abbott.

    Westphal, J.R.

    2004-01-01

    ABT-510 is a small peptide thrombospondin-1 mimetic angiogenesis inhibitor under development by Abbott Laboratories for the potential treatment of solid tumors. ABT-510 is undergoing phase II clinical trials.

  7. Technology evaluation: adalimumab, Abbott laboratories.

    Lorenz, Hanns M

    2002-04-01

    Adalimumab (D2E7), a human monoclonal antibody that binds to and neutralizes TNFa, is being developed by Abbott (formerly Knoll), under license from Cambridge Antibody Technology (CAT), for the potential treatment of inflammatory disorders such as rheumatoid arthritis (RA) and Crohn's disease. It is also being investigated for the potential treatment of coronary heart disease. Phase II studies for Crohn's disease and phase III for RA were ongoing throughout 2001. Limited data are only available for RA. In January 2002, it was reported that phase III trials of adalimumab for RA had been completed, but details have not been published in the primary literature so far. At this time CAT and Abbott expected to file for US approval in the second quarter of 2002 with a launch date anticipated for 2003. Phase III data are expected to be presented at the European League Against Rheumatism meeting in June 2002. In November 2000, Lehman Brothers predicted a US launch in June 2002 with peak US sales of $600 million in 2007 and a launch in non-US markets in 2003 with peak sales in these markets of $300 million in 2008. In December 2000, Merrill Lynch predicted regulatory clearance in the second half of 2003. The probability of adalimumab reaching the market is estimated to be 70%. In December 2000, Merrill Lynch predicted a 2003 launch, with estimated sales of pounds sterling 3.65 million in that year rising to pounds sterling 30.14 million in 2010. In March 2001, ABN AMRO predicted sales of $73 million in 2003 rising to $392 million in 2007. PMID:12044041

  8. 75 FR 80061 - Abbott Laboratories, Inc.; Withdrawal of Approval of a New Drug Application for MERIDIA

    2010-12-21

    ... HUMAN SERVICES Food and Drug Administration Abbott Laboratories, Inc.; Withdrawal of Approval of a New... (sibutramine hydrochloride (HCl)) oral capsules held by Abbott Laboratories, Inc. (Abbott), 100 Abbott Park Rd., Abbott Park, IL 60064. Abbott has voluntarily requested that approval of this application be...

  9. 77 FR 13232 - Abbott Laboratories; Filing of Food Additive Petition

    2012-03-06

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 172 Abbott Laboratories; Filing of Food Additive... Administration (FDA) is announcing that Abbott Laboratories has filed a petition proposing that the food additive...))), notice is given that a food additive petition (FAP 2A4788) has been filed by Abbott Laboratories,...

  10. 77 FR 4368 - Abbott Laboratories, Diagnostics Division, Including On-Site Leased Workers From Manpower...

    2012-01-27

    ... Employment and Training Administration Abbott Laboratories, Diagnostics Division, Including On-Site Leased... for Worker Adjustment Assistance on February 24, 2011, applicable to workers of Abbott Laboratories... location of Abbott Laboratories, Diagnostics Division. The Department has determined that these...

  11. Australopithecine enamel prism patterns.

    Vrba, E S; Grine, F E

    1978-11-24

    Following a recent suggestion that tooth enamel prism shape differs within Hominoidea, the teeth of a number of extinct and extant hominoid species were analyzed by scanning electron microscopy. The enamel prism patterns of some gracile and robust australopithecine specimens from Sterkfontein, Swartkrans, and Kromdraai are recorded. The characteristic arrangements of enamel prisms in all modern and extinct hominoid species were found to be essentially similar. The implications of enamel prisms for phylogenetic deduction in Hominoidea are discussed. PMID:102032

  12. Berenice Abbott (1898-1991, photographies

    Juliette Mélia

    2012-05-01

    Full Text Available C’est la première fois que Berenice Abbott est exposée à Paris. Les cent vingt images et trente documents présentés au Jeu de Paume sont regroupés en quatre grandes séries, qui correspondent aux quatre grandes phases de sa carrière photographique. La première partie retrace son œuvre de portraitiste, qui commence à Paris au début des années 1920, où elle photographie des anonymes, mais aussi beaucoup d’artistes et d’écrivains tels que Marcel Duchamp, Jean Cocteau, James Joyce, ou encore Djuna...

  13. Collaborative evaluation of the Abbott yeast identification system.

    Cooper, B. H.; Prowant, S; B. Alexander; Brunson, D H

    1984-01-01

    The Abbott yeast identification system (Abbott Laboratories, Diagnostics Division, Irving, Tex.) is a 24-h, instrumental method for identifying medically important yeasts, based on matrix analysis of 19 biochemical reactions and the germ tube test. The system was evaluated in two clinical laboratories by using 179 coded isolates, which included a high percentage of the less frequently encountered species. Based upon results with these coded isolates and from previously obtained laboratory dat...

  14. Multisite Analytical Evaluation of the Abbott ARCHITECT Cyclosporine Assay.

    Wallemacq, Pierre; Maine, Gregory,; Berg, Keith; Rosiere, Thomas; Marquet, Pierre; Aimo, Giuseppe; Mengozzi, Giulio; Young, Juliana; Wonigert, Kurt; Krestchmer, Robert; Wermuth, Bendicht; Schmid, Rainer,

    2010-01-01

    International audience The objective of this study was to evaluate the analytical performance of the Abbott ARCHITECT Cyclosporine (CsA) immunoassay in 7 clinical laboratories in comparison to liquid chromatography/tandem mass spectrometry (LC/MS/MS), Abbott TDx, Cobas Integra 800, and the Dade Dimension Xpand immunoassay. The ARCHITECT assay uses a whole blood specimen, a pretreatment step with organic reagents to precipitate proteins and extract the drug, followed by a 2-step automated i...

  15. Viterbi training in PRISM

    Sato, Taisuke; Kubota, Keiichi

    2013-01-01

    VT (Viterbi training), or hard EM, is an efficient way of parameter learning for probabilistic models with hidden variables. Given an observation $y$, it searches for a state of hidden variables $x$ that maximizes $p(x,y \\mid \\theta)$ by coordinate ascent on parameters $\\theta$ and $x$. In this paper we introduce VT to PRISM, a logic-based probabilistic modeling system for generative models. VT improves PRISM in three ways. First VT in PRISM converges faster than EM in PRISM due to the VT's t...

  16. The PRISM Benchmark Suite

    Kwiatkowsa, Marta; Norman, Gethin; Parker, David

    2012-01-01

    We present the PRISM benchmark suite: a collection of probabilistic models and property specifications, designed to facilitate testing, benchmarking and comparisons of probabilistic verification tools and implementations.

  17. Quantification of HBsAg: Basic virology for clinical practice

    Jung Min Lee; Sang Hoon Ahn

    2011-01-01

    Hepatitis B surface antigen (HBsAg) is produced and secreted through a complex mechanism that is still not fully understood. In clinical fields, HBsAg has longserved as a qualitative diagnostic marker for hepatitis B virus infection. Notably, advances have been made in the development of quantitative HBsAg assays, whichhave allowed viral replication monitoring, and there is an opportunity to make maximal use of quantitative HBsAg to elucidate its role in clinical fields. Yet, it needs to be underscored that a further understanding of HBsAg, not only from clinical point of view but also from a virologic point of view, would enable us to deepen our insights, so that we could more widely expand and applyits utility. It is also important to be familiar with HBsAg variants and their clinical consequences in terms of immune escape mutants, issues resulting from overlap with corresponding mutation in the P gene, and detection problems for the HBsAg variants. In this article, we review current concepts and issues on the quantificationof HBsAg titers with respect to their biologic nature, method principles, and clinically relevant topics.

  18. Analýza marketingové komunikace divize Abbott Diabetes Care, spol. Abbott Laboratories, s.r.o.

    Iblová, Mirka

    2009-01-01

    This dissertation discusses the analysis of marketing communication within Abbott Laboratories Ltd. division of Abbott Diabetes Care, which carry business within the market of pharmaceutical industry. Prior to the analysis, the focus is on the theoretical part of the traditional components of the communication mix. In the practical part, the theoretical knowledge is then applied to the chosen example of the company. On the basis of performed analysis, recommendations are proposed in order to ...

  19. Penta prism laser polarizer.

    Lotem, H; Rabinovitch, K

    1993-04-20

    A novel type of laser prism polarizer is proposed. The polarizer is characterized by a high transmission efficiency, a high optical damage threshold, and a high extinction ratio. The polarizer is shaped like a regular penta prism and, thus, it is a constant deviation angle device. Polarization effects occur upon the two internal cascade reflections in the prism. Anisotropic and Isotropic types of the polarizer are discussed. The isotropic polarizer is a prism made of a high refractive-index glass coated by multilayer polarization-type dielectric coatings. Efficient s-state polarization is obtained because of p-state leakage upon the two internal cascade reflections. The anisotropic polarizer is made of a birefringent crystal in which angular polarization splitting is obtained by the bireflectance (double-reflection) effect. Fanning of a laser beam into up to eight polarized beams is possible in a prism made of a biaxial crystal. PMID:20820335

  20. PRISM Spectrograph Optical Design

    Chipman, Russell A.

    1995-01-01

    The objective of this contract is to explore optical design concepts for the PRISM spectrograph and produce a preliminary optical design. An exciting optical configuration has been developed which will allow both wavelength bands to be imaged onto the same detector array. At present the optical design is only partially complete because PRISM will require a fairly elaborate optical system to meet its specification for throughput (area*solid angle). The most complex part of the design, the spectrograph camera, is complete, providing proof of principle that a feasible design is attainable. This camera requires 3 aspheric mirrors to fit inside the 20x60 cm cross-section package. A complete design with reduced throughput (1/9th) has been prepared. The design documents the optical configuration concept. A suitable dispersing prism material, CdTe, has been identified for the prism spectrograph, after a comparison of many materials.

  1. 76 FR 4283 - Foreign-Trade Zone 153-San Diego, CA; Application for Manufacturing Authority; Abbott...

    2011-01-25

    ...; Abbott Cardiovascular Systems, Inc. (Cardiovascular Device Manufacturing); Riverside County, CA An.... (Abbott), located in Riverside County, California. The application was submitted pursuant to the... sourced from abroad (representing 5% of the value of the finished product) include: resins, plastic...

  2. Acoustic dispersive prism

    Hussein Esfahlani; Sami Karkar; Herve Lissek; Mosig, Juan R.

    2016-01-01

    The optical dispersive prism is a well-studied element, which allows separating white light into its constituent spectral colors, and stands in nature as water droplets. In analogy to this definition, the acoustic dispersive prism should be an acoustic device with capability of splitting a broadband acoustic wave into its constituent Fourier components. However, due to the acoustical nature of materials as well as the design and fabrication difficulties, there is neither any natural acoustic ...

  3. 77 FR 75610 - Foreign-Trade Zone 22-Chicago, IL, Notification of Proposed Production Activity, Abbott...

    2012-12-21

    ..., Abbott Laboratories, Inc., AbbVie, Inc. (Pharmaceutical Production), North Chicago, IL, Area Abbott Laboratories, Inc. (Abbott) and AbbVie, Inc. (AbbVie) submitted a notification for expanded production... (Board Order 611, 12/ 14/1991, 57 FR 61045, 12/14/1992) and authority was later expanded in 1999 and...

  4. 78 FR 54487 - Abbott Laboratories; Diagnostic-Hematology; Including On-Site Leased Workers From Manpower...

    2013-09-04

    ... Employment and Training Administration Abbott Laboratories; Diagnostic--Hematology; Including On-Site Leased... on-site at the Santa Clara, California location of Abbott Laboratories, Diagnostic--Hematology... International, reporting to Abbott Laboratories, Diagnostic--Hematology division, including on-site...

  5. Screening of HBsAg and anti HCV from tertiary care, private and public sector hospitals

    Objectives: To find out the frequency of hepatitis B surface antigen and hepatitis C antibodies in patients referred from a tertiary care public sector hospital, other public sector and private hospitals of Karachi. Settings and duration: Pakistan Medical Research Council's Specialized Research Centre for Gastroenterology and Hepatology, at Jinnah Postgraduate Medical Centre Karachi from January to December 2009. Patients and Methods: A cross sectional study was conducted where patients were referred from different departments of Jinnah Postgraduate Medical Centre (tertiary care public sector hospital), other public sector hospitals, private hospitals and clinics for the screening of hepatitis B and C virus infection. Three ml blood was collected from each patient, serum separated and tested for HBsAg and Anti HCV using Abbott Murex fourth Generation ELISA kits. Results: A total of 2965 cases were referred in a year. Overall sero prevalence of HBsAg and Anti-HCV was 5.9% and 12.8% respectively. HBsAg positivity in patient referred from public sector hospitals was 5.8%, those from private hospitals/clinics were 7.2%, and self-referred patients was 5.6%. Anti HCV positivity rates amongst these cases were 12.5%, 16.7% and 8.5% respectively. Co-infection of hepatitis B virus and hepatitis C virus was seen in 0.9, 2.5 and 1.4% cases respectively. Breakdown of viral positivity within different departments of Jinnah Postgraduate Medical Centre Karachi showed HBsAg positivity of 7.1% in Medical department, 5.2% in Surgical department, 5.0% in Gynaecology department, 6.6% in other departments of Jinnah Postgraduate Medical Centre while, only 1.7% were positive from Pakistan Railway, hospital Anti HCV positivity was maximally (20.3%) seen in medical department followed by 14% in other departments, 10.9% in surgical department, 7.9% in gynaecology and 5.1% in railway hospital. Co-infection of HBV and HCV was seen in 2% cases referred from medical department, while rest of the

  6. Frequency of HBsAg, anti-HCV, and anti-HIV in pregnant women and/or patients with gynecologic diseases in a tertiary hospital

    Tülay Özlü

    2013-06-01

    Full Text Available Objective: Hepatitis B virus (HBV, hepatitis C virus (HCV and human immunodeficiency virus (HIV are viruses that can be transmitted to the health care workers by infected body fluids and from mother to the baby before, during or after delivery. In the present study, we aimed to investigate the frequency of hepatitis B surface antigens (HBsAg, hepatitis C antibodies (anti-HCV, and HIV antibodies (anti-HIV in pregnant women and/or patients with gynecologic diseases that admit to a university hospital in Bolu.Methods: HBsAg, anti-HCV, and anti-HIV results of the pregnant women and/or patients with gynecologic diseases that admitted to the obstetrics and gynecology clinics between January 2006 and June 2012 were retrospectively investigated. All markers were tested in the microbiology laboratory of our hospital by using macro ELISA method (Axsyme and Architect i2000SR systems, Abbott Diagnostics, Chicago, IL, USA.Results: The frequency of HBsAg, anti-HCV, and antiHIV positivity were 1.8%, 0.5%, and 0% in pregnant women and 1.9%, 1.1%, and 0% in patients with gynecologic diseases, respectively.Conclusion: The frequencies detected in our hospital are at low levels as seen in developed countries. Since there is no effective method of prevention especially from HCV, awareness of this serologic result before high risk procedures will enable the doctors and the health care workers to take extensive measures to prevent the transmission of the disease. J Clin Exp Invest 2013; 4 (2: 166-170Key words: anti-HCV, anti-HIV, HBsAg, pregnant women, gynecology

  7. The Instructional Guide for Abbott Skills Enhancement Classes. Revised Edition.

    Ballinger, Ronda; Gee, Mary Kay

    This guide, which integrates adult basic education (ABE) curriculum, job skills for Abbott Laboratories, and work-related foundation skills, is designed for an instructional program in the skill areas of reading, writing, oral communications, mathematics, and problem solving. In addition to creating a uniform process and product to promote…

  8. Geometric formula for prism deflection

    Apoorva G Wagh; Veer Chand Rakhecha

    2004-08-01

    While studying neutron deflections produced by a magnetic prism, we have stumbled upon a simple `geometric' formula. For a prism of refractive index close to unity, the deflection simply equals the product of the refractive power − 1 and the base-to-height ratio of the prism, regardless of the apex angle. The base and height of the prism are measured respectively along and perpendicular to the direction of beam propagation within the prism. The geometric formula greatly simplifies the optimisation of prism parameters to suit any specific experiment.

  9. PRISM project optical instrument

    Taylor, Charles R.

    1994-01-01

    The scientific goal of the Passively-cooled Reconnaissance of the InterStellar Medium (PRISM) project is to map the emission of molecular hydrogen at 17.035 micrometers and 28.221 micrometers. Since the atmosphere is opaque at these infrared wavelengths, an orbiting telescope is being studied. The availability of infrared focal plane arrays enables infrared imaging spectroscopy at the molecular hydrogen wavelengths. The array proposed for PRISM is 128 pixels square, with a pixel size of 75 micrometers. In order to map the sky in a period of six months, and to resolve the nearer molecular clouds, each pixel must cover 0.5 arcminutes. This sets the focal length at 51.6 cm. In order for the pixel size to be half the diameter of the central diffraction peak at 28 micrometers would require a telescope aperture of 24 cm; an aperture of 60 cm has been selected for the PRISM study for greater light gathering power.

  10. Prism vergence measurements following adaptation to a base out prism

    Tuff, L.C.; Firth, A Y; Griffiths, H.J.

    2000-01-01

    This study examines the effect of adaptation on the prism vergence range following an induced deviation. Five young adult subjects, with normal binocular functions, underwent fusional verfence testing to base in prisms before and after wearing a 10(Δ) base out Fresnel prism. The Fresnel prism was worn for a period of 2, 5, or 10 min on each of three separate occasions. The base in fusional vergence showed no statistical difference before or after adaptation, for any of the time periods. Also ...

  11. 77 FR 16039 - Abbott Laboratories et al.; Withdrawal of Approval of 35 New Drug Applications and 64 Abbreviated...

    2012-03-19

    ... HUMAN SERVICES Food and Drug Administration Abbott Laboratories et al.; Withdrawal of Approval of 35 New... Application No. Drug Applicant NDA 005545 Dicumarol Tablets... Abbott Laboratories, PA77/Bldg. AP30-1E, 200...)) Injection Preservative Free. NDA 010021 Placidyl Abbott Laboratories, (ethchlorvynol) 200 Abbott...

  12. Ultra-dispersive adaptive prism

    Sautenkov, Vladimir A.; Li, Hebin; Rostovtsev, Yuri V.; Scully, Marlan O.

    2007-01-01

    We have experimentally demonstrated an ultra-dispersive optical prism made from coherently driven Rb atomic vapor. The prism possesses spectral angular dispersion that is six orders of magnitude higher than that of a prism made of optical glass; it is the highest spectral angular dispersion that has ever been shown (such angular dispersion allows one to spatially resolve light beams with different frequencies separated by a few kHz). The prism operates near the resonant frequency of atomic va...

  13. Dove prism heterodyne refractometer

    Hsu, Cheng-Chih; Lee, Chia-Yun; Chu, Kuan-Ho; Wu, Tsai-Chen

    2015-10-01

    In this study, we proposed an alternative method, integrating a Dove prism and precision circular heterodyne interferometry, for measuring the refractive index and concentration of sodium chloride and hydrogen peroxide solutions with low phase error. Due to the optical properties of the Dove prism, the test light undergoes total internal reflection (TIR) at the interface between the test sample and the prism. The light beam travels in and out of the Dove prism while maintaining the same direction. Therefore, only slight alignment is required, leading to only small errors in the phase and refractive index. In this study, the phase error, refractive index error, and resolution of the concentration are approximated to be 0.003°, 2×10-5, and 1×10-3 M, respectively. The proposed method has the advantages of a simple optical configuration, ease of operation, little alignment required, and high stability, and it allows for high-precision measurement of the refractive index and concentration of the liquid sample.

  14. Prism Adaptation in Schizophrenia

    Bigelow, Nirav O.; Turner, Beth M.; Andreasen, Nancy C.; Paulsen, Jane S.; O'Leary, Daniel S.; Ho, Beng-Choon

    2006-01-01

    The prism adaptation test examines procedural learning (PL) in which performance facilitation occurs with practice on tasks without the need for conscious awareness. Dynamic interactions between frontostriatal cortices, basal ganglia, and the cerebellum have been shown to play key roles in PL. Disruptions within these neural networks have also…

  15. Generalization of Prism Adaptation

    Redding, Gordon M.; Wallace, Benjamin

    2006-01-01

    Prism exposure produces 2 kinds of adaptive response. Recalibration is ordinary strategic remapping of spatially coded movement commands to rapidly reduce performance error. Realignment is the extraordinary process of transforming spatial maps to bring the origins of coordinate systems into correspondence. Realignment occurs when spatial…

  16. Acoustic dispersive prism

    Esfahlani, Hussein; Karkar, Sami; Lissek, Herve; Mosig, Juan R.

    2016-01-01

    The optical dispersive prism is a well-studied element, which allows separating white light into its constituent spectral colors, and stands in nature as water droplets. In analogy to this definition, the acoustic dispersive prism should be an acoustic device with capability of splitting a broadband acoustic wave into its constituent Fourier components. However, due to the acoustical nature of materials as well as the design and fabrication difficulties, there is neither any natural acoustic counterpart of the optical prism, nor any artificial design reported so far exhibiting an equivalent acoustic behaviour. Here, based on exotic properties of the acoustic transmission-line metamaterials and exploiting unique physical behaviour of acoustic leaky-wave radiation, we report the first acoustic dispersive prism, effective within the audible frequency range 800 Hz-1300 Hz. The dispersive nature, and consequently the frequency-dependent refractive index of the metamaterial are exploited to split the sound waves towards different and frequency-dependent directions. Meanwhile, the leaky-wave nature of the structure facilitates the sound wave radiation into the ambient medium.

  17. Reflection by Porro Prisms

    Greenslade, Thomas B.

    2010-04-01

    Students all know that reflection from a plane mirror produces an image that is reversed right to left and so cannot be read by anyone but Leonardo da Vinci, who kept his notes in mirror writing. A useful counter-example is the Porro prism, which produces an image that is not reversed.

  18. Avoidance of generic competition by Abbott Laboratories' fenofibrate franchise.

    Downing, Nicholas S; Ross, Joseph S; Jackevicius, Cynthia A; Krumholz, Harlan M

    2012-05-14

    The ongoing debate concerning the efficacy of fenofibrate has overshadowed an important aspect of the drug's history: Abbott Laboratories, the maker of branded fenofibrate, has produced several bioequivalent reformulations that dominate the market, although generic fenofibrate has been available for almost a decade. This continued use of branded formulations, which cost twice as much as generic versions of fenofibrate, imposes an annual cost of approximately $700 million on the US health care system. Abbott Laboratories maintained its dominance of the fenofibrate market in part through a complex switching strategy involving the sequential launch of branded reformulations that had not been shown to be superior to the first-generation product and patent litigation that delayed the approval of generic formulations. The small differences in dose of the newer branded formulations prevented their substitution with generics of older-generation products. As soon as direct generic competition seemed likely at the new dose level, where substitution would be allowed, Abbott would launch another reformulation, and the cycle would repeat. Based on the fenofibrate example, our objective is to describe how current policy can allow pharmaceutical companies to maintain market share using reformulations of branded medications, without demonstrating the superiority of next-generation products. PMID:22493409

  19. A displacement-doubling prism

    A novel prism has been devised which can be used in place of the ‘flag’ in an optical shadow-sensing type of displacement sensor, for example. In this way, theoretically the displacement sensitivity of the sensor can be doubled. Such a prism has been manufactured, and its displacement-doubling property has been verified. - Highlights: • A new type of glass prism doubles linear displacement of optical beams. • Optical operation has been verified. • Light beams enter and exit at normal incidence to prism's windows. • Optical path length through prism remains constant, as prism is moved. • Designed to double the displacement sensitivity of knife-edge shadow sensors

  20. 78 FR 23220 - Foreign-Trade Zone 22-Chicago, Illinois, Authorization of Production Activity, Abbott...

    2013-04-18

    ..., Abbott Laboratories, Inc., AbbVie, Inc. (Pharmaceutical Production), North Chicago, Illinois, Area On December 14, 2012, Abbott Laboratories, Inc., and AbbVie, Inc., submitted a notification for expanded... FTZ Board (15 CFR part 400), including notice in the Federal Register inviting public comment (77...

  1. Multibeam collimator uses prism stack

    Minott, P. O.

    1981-01-01

    Optical instrument creates many divergent light beams for surveying and machine element alignment applications. Angles and refractive indices of stack of prisms are selected to divert incoming laser beam by small increments, different for each prism. Angles of emerging beams thus differ by small, precisely-controlled amounts. Instrument is nearly immune to vibration, changes in gravitational force, temperature variations, and mechanical distortion.

  2. Anti-HAV seropositivity in adult patients with HBsAg positive from various locations of Turkey

    Mesut ORTATATLI

    2012-04-01

    Full Text Available Objective: This study aims to determine the rate of hepatitis A virus (HAV seropositivity in adult HBsAg (+ patients from various regions of Turkey.Method: 137 adult (≥20 age male patients admitted to Erzurum Mareşal Çakmak Military Hospital in 2009 who were previously diagnosed as HBsAg(+ were included. The subjects were not vaccinated for HAV. Serum samples were analyzed by EIA (enzyme immunassay using Abbott/AxSYM. Chi-square test was used for statistical analysis of serological data.Results: The Anti-HAV IgG (+ rates was 83.2% in the study populations (114/137, 61.5% (8/13 for those from Marmara region, 83.3% (13/16 for Mediterranean region, 84.6% (22/26 for Mid-Anatolian region, 66.7% (8/12 for Blacksea region, 87.5% (21/24 for East Anatolian region, 94.1% (32/34 for Southeast-Anatolian region. According to our study, no significant difference was found between seven geographical regions due to HAV seropozitivity rates (χ2= 9.511, p=0.147. The seven geographical regions were classified two main grups as East-Southeast Anatolia and other regions. The percentage of anti-HAV positivity rate was significantly higher in East-Southeast Anatolia grup (91.4%; 53/58 comparedto other regions grup (77.2%; 61/79 (χ2= 4.803;p=0.028.Conclusion: The prevalance of Hepatitis A variesin different countries and even in different regionsof a specific country. Age, low socioeconomic leveland worse living conditions have been reportedas the most important risk factors in studies withhealthy individuals. In this study where subjects withHBsAg(+ were evaluated for anti-HAV positivity, anincrease in the risk was found as OR =3.13 times larger(95% confidence interval, 1.09-9.01 when especiallyliving conditions in East-Southeast Anatolia wascompared with other regions. It has been postulatedthat all patients monitored for chronic HBV infectionshould be assessed for anti-HAV IgG and negativeindividuals need to be vaccinated due to highermortality and more severe

  3. Optical design of prism-grating-prism imaging spectrometers

    Zhu, Shanbing; Tang, Minxue; Ji, Yiqun; Gong, Guangbiao; Zhang, Ruirui; Shen, Weimin

    2008-12-01

    Imaging spectrometers can provide imagery and spectrum information of objects and form so-called three-dimensional spectral imagery, two spatial and one spectral dimension. Most of imaging spectrometers use conventional spectroscopic elements or systems, such as reflective diffraction gratings, prisms, filters, spatial modulated interferometers, and so on. Here a special imaging spectrometer which is based on a novel cemented Prism-Grating-Prism (PGP) is reported. Its spectroscopic element PGP consists of two prisms and a holographic transmission volume grating, which is cemented between these prisms. The two prisms mainly function as beam deviation, the grating as a disperser. In addition to the high light efficiency of the volume gratings that is required for high spectral resolution, the cementing difficulty when surface relief gratings are used can be avoided due to its voluminal characteristic. The PGP imaging spectrometer has advantages of direct vision, dispersion uniform, compactness, low cost, and facility to be used. The principle, structure, and optimized design of the PGP imaging spectrometer are given in detail. Its front collimation optics and rear focusing lenses are same so as to reduce its cost further. The spectral coverage, resolution, and track length of the designed system are respectively visible light from 400nm to 800nm, 1.6nm/pixel, and 85mm. From its performance evaluation, it is shown that the PGP imaging spectrometer has the potentiality to be used in microscopic hyperspectral imagers and hyperspectral imaging remote sensors.

  4. 21 CFR 886.1660 - Gonioscopic prism.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Gonioscopic prism. 886.1660 Section 886.1660 Food... DEVICES OPHTHALMIC DEVICES Diagnostic Devices § 886.1660 Gonioscopic prism. (a) Identification. A gonioscopic prism is a device that is a prism intended to be placed on the eye to study the anterior...

  5. [Diagnostic value of the quantitative HBsAg determination in hepatitis B infections].

    van Helden, J; Weiskirchen, R

    2016-04-01

    Introduction of systematic hepatitis B vaccination has lead to a strong decrease of new infections, but there are still a high numbers of chronically infected persons suffering on long-term complications. Using quantitative assays for the determination of HbsAg (qHBsAg) has improved our understanding of chronic hepatitis B (CHB). The concentrations of HBsAg are strongly varying through the different stages of infection. The quantitative determination of HBsAg does not only yield in additional information to the infection activity, but also provides data for an improved follow up independent from the virus load. As to the prediction of disease progression, low-viremic carriers with high HbsAg levels have been shown to be at higher risk of HBeAg negative hepatitis, cirrhosis and hepatocellular carcinoma (HCC). Although, quantitative HBsAg determination has been widely used in CHB patients receiving pegylated interferon therapy, the HbsAg decline is slow compared to HBV-DNA levels during nucleos(t)ide analogue (NUC) therapy. However a rapid HbsAg decline during NUC therapy may identify patients who will finally clear HbsAg. A 6- to 12-monthly assessment of HbsAg level could be considered during NUC therapy. Taking these lines of evidence together, qHBsAg can complement HBV-DNA levels to optimize the management of CHB patients. PMID:27056461

  6. Oral vaccination of mice with Tremella fuciformis yeast-like conidium cells expressing HBsAg.

    Shin, Dong-Il; Song, Kyu-Seon; Park, Hee-Sung

    2015-03-01

    Tremella fuciformis yeast-like conidium (YLC) cells were transformed by co-cultivation with Agrobacterium cells harboring the hepatitis B surface antigen (HBsAg) gene construct under the control of the CaMV35S promoter. Integration of HBsAg DNA into the YLC genome was confirmed by PCR and dot-blot hybridization. Immunoblotting verified expression of the recombinant protein. Oral administration of YLC cells expressing HBsAg in mice significantly increased anti-HBsAg antibody titer levels using a double prime-boost strategy that combined parenteral and oral HBsAg boosters. PMID:25374008

  7. Prism Window for Optical Alignment

    Tang, Hong

    2008-01-01

    A prism window has been devised for use, with an autocollimator, in aligning optical components that are (1) required to be oriented parallel to each other and/or at a specified angle of incidence with respect to a common optical path and (2) mounted at different positions along the common optical path. The prism window can also be used to align a single optical component at a specified angle of incidence. Prism windows could be generally useful for orienting optical components in manufacture of optical instruments. "Prism window" denotes an application-specific unit comprising two beam-splitter windows that are bonded together at an angle chosen to obtain the specified angle of incidence.

  8. A neutron prism

    A neutron detector with an energy and time resolution makes it possible to realize a new type of a scattering instrument. Such kind of detector can be developed by combining the neutron refractive device (neutron prism) and position-sensitive-detector (PSD) with a time resolution. As the neutron refractive device, two candidates are considered; a compound refractive device and magnetic field gradient. In former case, suitable choice of material and design of the refractive device overcomes a problem of neutron absorption and weak refraction due to material. On the other hand, the magnetic field gradient has an advantage that it has a large refraction and zero neutron absorption comparing with the compound refractive device. A refractive device has been developed with suitable material and design for neutron optics and a quadrupole magnet with permanent magnets in which a constant field gradient is realized. In this paper, the construction and performance of the energy and time resoluble detectors using the neutron refractive devices are described and their application to a neutron scattering experiment is discussed. (author)

  9. Enhanced HBsAg synthesis correlates with increased severity of fibrosis in chronic hepatitis B patients.

    Mei-Zhu Hong

    Full Text Available BACKGROUND AND AIMS: Little is known about whether low serum HBsAg levels result from impaired HBsAg synthesis or a reduced number of hepatocytes caused by advanced liver fibrosis. Therefore, we investigated the capacity for HBsAg synthesis in a cross-sectional cohort of treatment-naïve chronic hepatitis B patients. METHODS: Chronic hepatitis B patients (n = 362 were enrolled; liver biopsies were performed and liver histology was scored, and serum HBsAg and HBV DNA levels were investigated. In the enrolled patients, 183 out of 362 have quantitative serum HBsAg levels. Tissue HBsAg was determined by immunohistochemistry. RESULTS: A positive correlation between serum HBsAg and HBV DNA levels was revealed in HBeAg(+ patients (r = 0.2613, p = 0.0050. In HBeAg(+ patients, serum HBsAg and severity of fibrosis were inversely correlated (p = 0.0094, whereas tissue HBsAg levels correlated positively with the stage of fibrosis (p = 0.0280. After applying the mean aminopyrine breath test as a correction factor, adjusted serum HBsAg showed a strong positive correlation with fibrosis severity in HBeAg(+ patients (r = 0.5655, p<0.0001. The adjusted serum HBsAg values predicted 'moderate to severe' fibrosis with nearly perfect performance in both HBeAg(+ patients (area under the curve: 0.994, 95% CI: 0.983-1.000 and HBeAg(- patients (area under the curve: 1.000, 95% CI: 1.000-1.000. CONCLUSIONS: Although serum HBsAg levels were negatively correlated with fibrosis severity in HBeAg(+ patients, aminopyrine breath test-adjusted serum HBsAg and tissue HBsAg, two indices that are unaffected by the number of residual hepatocytes, were positively correlated with fibrosis severity. Furthermore, adjusted serum HBsAg has an accurate prediction capability.

  10. Detection of respiratory syncytial virus antigen in nasal washings by Abbott TestPack enzyme immunoassay.

    Wren, C G; Bate, B J; Masters, H B; Lauer, B A

    1990-01-01

    We compared the new Abbott TestPack (TP) respiratory syncytial virus (RSV) enzyme immunoassay (EIA) with cell culture and two commercial RSV EIAs (from Abbott Diagnostics and Kallestad Laboratories) by using split samples of fresh nasal washings from children with suspected RSV disease. Two tubes of HEp-2 cells were inoculated and observed for cytopathic effect for 14 days, and isolates were confirmed by immunofluorescence. The TP EIA was performed by following the manufacturer's instructions...

  11. Prognosis of chronic hepatitis B transmitted from HBsAg positive mothers.

    Bortolotti, F; Cadrobbi, P; Armigliato, M; Rude, L; Rugge, M; Realdi, G

    1987-01-01

    Nine children born to HBsAg positive mothers, who became chronic HBsAg carriers with associated liver disease, were followed for five to 10 years. Five children with active hepatitis or active cirrhosis at presentation achieved complete remission within six years, while three HBeAg positive patients with minimal histological lesions remained unchanged.

  12. High Prevalence of HBsAg during Pregnancy in Asian Communities at Cayenne Hospital, French Guiana

    Mahamat, Aba; Louvel, Dominique; Vaz, Tania; Demar, Magalie; Nacher, Mathieu; Djossou, Félix

    2010-01-01

    We described hepatitis B surface antigen (HBsAg) prevalence among 2,347 pregnant women having delivered at the Cayenne hospital in 2007 according to ethnicity. With 11.0% HBsAg prevalence, Asian women (Hmong and Chinese) were the group with the highest risk of hepatitis B virus (HBV) perinatal transmission compared with other ethnic groups.

  13. Low serum hyaluronic acid levels associated with spontaneous HBsAg clearance

    Harkisoen, S.; Arends, J. E.; van den Hoek, A.; van Erpecum, K. J.; Boland, G. J.; Hoepelman, A. I. M.

    2015-01-01

    Purpose The pathophysiological underlying mechanism of spontaneous HBsAg clearance in hepatitis B virus (HBV) infected patients is largely unknown. However, serum hyaluronic acid (sHA) plays a role in liver fibrosis progression and reversely could serve as a potential biomarker for HBsAg clearance.

  14. Evaluation of the Abbott LCx Assay for Detection of Neisseria gonorrhoeae in Endocervical Swab Specimens from Females

    Kehl, Sue C.; Georgakas, Kristina; Swain, Geoffrey R.; Sedmak, Gerald; Gradus, Stephen; Singh, Ajaib; Foldy, Seth

    1998-01-01

    The Abbott LCx Neisseria gonorrhoeae assay (Abbott Laboratories, Abbott Park, Ill.) uses a ligase chain reaction (LCR) amplification in the LCx probe system for detection of a specific nucleotide sequence in the Opa-encoding gene of N. gonorrhoeae. We evaluated the LCx assay in a comparison with conventional culture employing modified Thayer-Martin media for the detection of N. gonorrhoeae from female endocervical specimens obtained from patients attending a sexually transmitted disease clini...

  15. Deteksi HBsAg dan HBeAg dalam Saliva Pengidap Virus Hepatitis B

    Riemawati A. Lesmana

    2015-10-01

    Full Text Available Transmission of hepatitis B virus (HBV via blood or its product has been well established. However, body fluids like urine and saliva may also contain HBV. A complete HBV consists of HBsAg, HBeAg, HBcAg dan partikel DNA. Hepatitis B carrier is detected by the presence of serologic marker HBsAg while the ongoing viral replication or infectivity is diagnosed by the presence of HBeAg or DNA particle. Meanwhile dentists will often contact with the saliva of their patients in daily practice. This cross-sectional study was carried out to assess the infectivity of the saliva of HBV carriers. During a 10 month period (August 1994 - May 1995 detection of HBsAg and HBeAg in blood and saliva were done in 97 HBV carriers using the ELISA method (Enzyme Linked Immunosorbent Assay. Of 97 HBV carriers both positive gor HBsAG in blood were found 56 (Group I and positive HBsAg and negativa HBeAg in the other 41 (Group II. Examination of the saliva of HBV carriers in Group I showed positive HBsAg as well as HBeAg in 48 (85,7%, only positive for HBsAg in 5 (10,7% and both negative for HBsAg and HBeAg in the other 2 (3,6% where as in Group II positive for both HBsAg and HBeAG in the remaining 10 (24,4%. In conclusion, the majority of highly infectious hepatitis B carriers do also have infectious saliva which could be an important source of infection and transmission of the virus in the field of dentistry.

  16. Rotatable prism for pan and tilt

    Ball, W. B.

    1980-01-01

    Compact, inexpensive, motor-driven prisms change field of view of TV camera. Camera and prism rotate about lens axis to produce pan effect. Rotating prism around axis parallel to lens produces tilt. Size of drive unit and required clearance are little more than size of camera.

  17. Preserving with Prisms: Producing Nets

    Prummer, Kathy E.; Amador, Julie M.; Wallin, Abraham J.

    2016-01-01

    Two mathematics teachers in a small rural school decided to create a task that would engage seventh graders. The goal of the real-world activity was to help students develop geometric and spatial reasoning and to support their understanding of volume of rectangular prisms. The impetus for the task came from the teachers' desire to engage students…

  18. Cethromycin: A-195773, A-195773-0, A-1957730, Abbott-195773, ABT 773.

    2007-01-01

    Cethromycin [ABT 773, A-195773, Abbott-195773, A-1957730, A-195773-0] is a once-daily ketolide antibiotic that originated from Abbott Laboratories' research into next-generation compounds to the macrolide antibacterial, clarithromycin. The aim of the research programme was to maintain the positive attributes of clarithromycin and to add the property of efficacy against macrolide-resistant organisms. Cethromycin acts by binding to the 23S molecule of the 50S ribosomal subunit. Advanced Life Sciences is conducting multinational, pivotal phase III trials of cethromycin for the treatment of mild-to-moderate community-acquired pneumonia, phase II/III trials for treatment of acute bacterial sinusitis, as well as preclinical trials for the treatment of anthrax. Advanced Life Sciences plans to advance discussions with prospective commercialisation partners for cethromycin during 2006. Abbott Laboratories and Taisho Pharmaceutical entered a collaboration to develop and commercialise new macrolide antibacterials in October 1997. Each company brought its existing macrolides into the collaboration and both companies were to jointly develop novel new macrolides. Abbott was to have exclusive marketing, manfacturing and supply rights worldwide (except in Japan) to any compounds resulting from this collaboration. Taisho was to receive royalties on Abbott's sales in consideration of granted rights. In Japan, the two companies were to co-market any resulting macrolide antibacterials. This agreement extended to the development of cethromycin; however, the agreement was suspended in April 2004 and appears to have been terminated. Abbott exclusively licensed cethromycin to Advanced Life Sciences worldwide excluding Japan in December 2004. Advanced Life Sciences initiated commercial manufacturing agreements for cethromycin with DSM and Cardinal Health in May 2006. In March 2006, Advanced Life Sciences completed private placement of $US36 million from which the net proceeds will be used

  19. A Liquid Prism for Refractive Index Studies

    Edmiston, Michael D.

    2001-11-01

    A hollow glass prism filled with liquid becomes a "liquid prism". A simple method for constructing hollow glass prisms is presented. A method is given for a demonstration that uses the liquid prism with a laser or laser pointer so the audience can observe differences in refractive index for various liquids. The demonstration provides a quick and easy determination of the sugar content of soft drinks and juices. The prism makes it easy to determine a numerical value for the refractive index of a liquid.

  20. Breaking tolerance in hepatitis B surface antigen (HBsAg) transgenic mice by vaccination with cross-reactive, natural HBsAg variants

    Schirmbeck, Reinhold; Dikopoulos, Nektarios; Kwissa, Marcin;

    2003-01-01

    when mice were immunized with natural HBsAg(ayw), or HBsAg(adw2) variants differing within both epitopes by one or two residues. Expression of HBsAg(ayw) from a transgene in the liver renders (HBs-tg) mice tolerant to epitope 1 of HBsAg(ayw). CD8(+) T cells specific for epitope 1 could be primed in HBs...... HBs-tg mice showed reduced antigenemia. Hence, vaccination with natural HBsAg variants from different HBV sero/genotypes can prime cross-reactive, specific CD8(+) T cell immunity that breaks tolerance to HBsAg....

  1. Expression of hepatitis B surface antigen gene (HBsAg) in Laminaria japonica (Laminariales, Phaeophyta)

    2002-01-01

    A transformation model for Laminaria japonica was established from 1993 to 1998, on the basis of which the transgenic kelp with heterologous gene encoding hepatitis B surface antigen (HBsAg) was obtained by using the micro- particle bombardment transformation method. Results of quantitative ELISA showed that HBsAg in transgenic kelp was 0.529 μg/mg soluble proteins on average and the highest value was 2.497 μg/mg, implying that recombinant HBsAg had natural epitope. Further support for the integration of HBsAg gene into kelp genome was obtained by PCR- Southern and total DNA hybridization. Prospect of kelp bioreactor producing high value materials such as edible HBV vaccine was discussed as well.

  2. Oral immunization of animals with transgenic cherry tomatillo expressing HBsAg

    Gao, Yi; Ma, Ying; Li, Mei; Cheng, Tong; Li, Shao-Wei; Zhang, Jun; Xia, Ning-Shao

    2003-01-01

    AIM: To investigate the expression of recombinant HBsAg (rHBsAg) in transgenic cherry tomatillo in order to explore the feasibility of producing HBV oral vaccine with cherry tomatillo by animal immune tests.

  3. Comparative study of methods of detection of hepatitis ′B′ surface antigen (HBsAg.

    Parab V

    1989-04-01

    Full Text Available The serum samples were collected from 52 patients of acute viral hepatitis and 235 hospital staff from Kasturba Hospital for Infectious Diseases. HBsAg was detected in their sera by counter-immuno-electrophoresis (CIEP, reverse passive hemogglutination (RPHA and by micro-enzyme-linked-immunosorbent assay (ELISA technique. Among the patients, HBsAg was detected in 12 cases (23% by CIEP, in 18 cases (34% by RPHA and in 23 patients (45% by ELISA. In the hospital staff, HBsAg was detected in 4 samples (1.7% by CIEP, in 8 samples (3.5% by RPHA and in 32 samples (13.5% by ELISA. Thus ELISA was found to be the most sensitive technique in detecting HBsAg.

  4. Evaluation of the Abbott Real Time HCV genotype II assay for Hepatitis C virus genotyping

    Sariguzel, Fatma Mutlu; Berk, Elife; Gokahmetoglu, Selma; Ercal, Baris Derya; Celik, Ilhami

    2015-01-01

    Objective: The determination of HCV genotypes and subtypes is very important for the selection of antiviral therapy and epidemiological studies. The aim of this study was to evaluate the performance of Abbott Real Time HCV Genotype II assay in HCV genotyping of HCV infected patients in Kayseri, Turkey. Methods: One hundred patients with chronic hepatitis C admitted to our hospital were evaluated between June 2012 and December 2012, HCV RNA levels were determined by the COBAS® AmpliPrep/COBAS® TaqMan® 48 HCV test. HCV genotyping was investigated by the Abbott Real Time HCV Genotype II assay. With the exception of genotype 1, subtypes of HCV genotypes could not be determined by Abbott assay. Sequencing analysis was used as the reference method. Results: Genotypes 1, 2, 3 and 4 were observed in 70, 4, 2 and 24 of the 100 patients, respectively, by two methods. The concordance between the two systems to determine HCV major genotypes was 100%. Of 70 patients with genotype 1, 66 showed infection with subtype 1b and 4 with subtype 1a by Abbott Real Time HCV Genotype II assay. Using sequence analysis, 61 showed infection with subtype 1b and 9 with subtype 1a. In determining of HCV genotype 1 subtypes, the difference between the two methods was not statistically significant (P>0.05). HCV genotype 4 and 3 samples were found to be subtype 4d and 3a, respectively, by sequence analysis. There were four patients with genotype 2. Sequence analysis revealed that two of these patients had type 2a and the other two had type 2b. Conclusion: The Abbott Real Time HCV Genotype II assay yielded results consistent with sequence analysis. However, further optimization of the Abbott Real Time HCV Genotype II assay for subtype identification of HCV is required. PMID:26649001

  5. Clinical implications of HBsAg quantification in patients with chronic hepatitis B

    Mauro Viganò

    2012-01-01

    Full Text Available Quantification of serum hepatitis B surface antigen (HBsAg helps the management of patients with chronic hepatitis B virus (HBV infection. Median HBsAg levels differ significantly during the natural history of HBV infection, progressively declining from immune tolerance to inactive phase. The combination of an HBsAg <1000 IU/mL and HBV DNA <2000 IU/mL at a single time point accurately identifies true inactive carriers. During antiviral treatment, HBsAg levels decline more rapidly in patients under peg-interferon (Peg-IFN than in those under nucleos(tide analogues (NUC, and in responders to peg-IFN compared to non responders suggesting that a response-guided therapy in both HBeAg-positive and -negative patients treated with Peg-IFN could improve to cost-effectiveness of this therapeutic approach. Given the low rates of HBsAg clearance on NUC therapy, new studies to test whether Peg-IFN and NUC combination fosters HBsAg decline in long-term responders to NUC, are being explored.

  6. HDV Seroprevalence in HBsAg Positive Patients

    Objective: To find out the frequency of HDV seroprevalence and the demographic characteristics or HBsAg-HDV positive patients. Study Design: Cross-sectional analytical study. Place and Duration of Study: Jinnah Postgraduate Medical Centre and Civil Hospital, Medical Unit-III, Karachi, from March 2007 to April 2011. Methodology: Patients with positive HBsAg were included in the study. Those having co-infection with HCV or HIV, autoimmune hepatitis, alcoholic hepatitis, Wilson's disease and haemochromatosis were excluded. After detailed history and physical examination all the patients underwent laboratory workup including complete blood count, liver function test, viral profile (HAV, HCV, HIV and anti-HDV) and prothrombin time. While in selected patients, HBc (core) antibodies, ultrasound abdomen, serum iron profile, ANA and liver biopsy were also carried out whenever needed to establish a clinical stage of liver disease. Results: There were 374 patients with 266 (71.1%) males and 108 (28.9%) females with overall mean age of 31.64 +- 8.66 years. Overall frequency of anti-HDV antibodies positivity was found in 28.1% (n = 105) patients. HDV seropositivity was slightly more prevalent in males as compared to females (28.57% vs. 26.57%). HDV seropositivity frequency was significantly higher in patients who presented with acute hepatitis/hepatic failure as compared to other clinical diagnoses (p = 0.027) and in those sub-sets of patients who had raised ALT levels (p = 0.012). Conclusion: There was a high frequency of HDV seropositivity in the studied population particularly in males with acute hepatitis or hepatic failure, having raised ALT levels. The emphasis should be on preventive measures taken by other countries to reduce the prevalence of these treatment challenging infections. (author)

  7. A multicenter evaluation of the Abbott RealTime HCV genotype II assay

    Marco Ciotti

    2009-12-01

    Full Text Available Viral genotype is an important determinant of the therapeutical outcome of the chronic hepatitis C and is useful in clinical practice to determine the duration of treatment1.While the viral type shows a clear association with therapeutic success, there is currently no evidence to that effect for HCV subtype, whose value is thus confined to epidemiological studies.The Abbott RealTime HCV Genotype II assay, through the use of Minor Groove Binder probes (MGB is able to distinguish genotypes 1 to 6 (target 5’-UTR region and subtypes 1a and 1b (NS5B region. In four different Italian centers a comparison between the Abbott RealTime HCV Genotype II assay and the Versant HCV Genotype 2.0 (LIPA has been performed.A total of 143 non selected samples with the request of HCV genotyping have been analysed. 141/143 samples (98.6% have provided reportable results with both tests (2 indeterminates with LIPA. Concordance at the type level was 96.5% (136/141. Considering the 136 concordant samples, the distribution was as follows: type 1 = 61 (44.9%, 2 = 36 (26.5%, 3 = 21 (15.4%, 4 = 17 (12.5% 5 = 1 (0.7%. Both assays assigned subtype in 56/61 (91.8% samples of genotype 1 (3 and 2 samples only provided the type for LIPA and Abbott, respectively and 50/56 (89.3% had concordant subtype. It is worth to note that 4 of the 5 samples with discordant subtype Abbott 1a/LiPA 1b came from the only center that used for LIPA the 5-UTR amplicon, loosing the benefit of the core region which has been introduced in the version 2 of the test to improve the accuracy in distinguishing between 1a and 1b.There was only one discordant sample at type level (Abbott 4, LIPA 1b which after sequencing and phylogenetic analysis was resolved as type 4. Four mixed infections were detected, 3 with the Abbott test (two 1a+4 and one 1b+3 and 1 with the LIPA test (1a+3. In all cases the comparison test showed a single genotype 1 infection. The new Abbott RealTime HCV Genotype II assay showed a

  8. An Evaluation of the Main Performance of the Abbott Axsym System%美国Abbott Axsym免疫分析仪性能初步评价

    王红旗; 金晶; 成军; 孙长贵; 孙关忠

    2003-01-01

    目的对Abbott Axsym免疫分析仪性能进行评价.方法通过检测HBsAg,对Abbott Axsym免疫分析仪的灵敏度、特异性、正确检测率(可检测性)、重复性、线性及与ELISA检测HBsAg的相关性等指标进行测定.结果Abbott Axsym免疫分析仪的灵敏度达到0.16 μg/L,特异性为100%,正确检测率(可检测性)为99.72%,不同参比血清的总CV值在5.4%~9.4%之间波动,在0.1~100μg/L范围内线性良好(r=0.994 9),与ELISA比较,两法的符合率为97%,结论该仪器设计科学合理,检测快速方便,结果准确可靠,是大、中型医院临床实验室比较理想的免疫分析仪之一.

  9. Early Childhood Education: The Sustainability of the Benefits of Preschool Participation in Abbott Districts

    Fernandez, Norma

    2010-01-01

    The landmark New Jersey Supreme Court school funding case, "Abbott v. Burke", established the availability of preschool for all three- and four-year-olds living within the state's thirty-one poorest districts as a means of eradicating the effects of poverty. Longitudinal studies have shown the value of high quality preschool programs for improving…

  10. 75 FR 340 - Approval for Expansion of Subzone 22F, Abbott Molecular, Inc. (Pharmaceutical and Molecular...

    2010-01-05

    ...- 17-09); Whereas, notice inviting public comment has been given in the Federal Register (74 FR 8052... Foreign-Trade Zones Board Approval for Expansion of Subzone 22F, Abbott Molecular, Inc. (Pharmaceutical and Molecular Diagnostic Products), Chicago, IL, Area Pursuant to its authority under the...

  11. Reproducibility Problems with the Abbott Laboratories LCx Assay for Chlamydia trachomatis and Neisseria gonorrhoeae

    Gronowski, Ann M.; Copper, Susan; Baorto, David; Murray, Patrick R.

    2000-01-01

    This study demonstrates that significant reproducibility problems can occur during routine use of the Abbott Laboratories LCx assay for Chlamydia trachomatis and Neisseria gonorrhoeae. These problems can go undetected by the quality control procedures outlined in the manufacturer's package insert. We outline here procedures for detecting and preventing contamination and reproducibility problems.

  12. The Labour Process of Teaching at John Abbott College (Part One).

    Johnson, Walter

    This survey was conducted at John Abbott College to gauge teachers' responses to issues concerning their job satisfaction, interaction with colleagues, perceptions of student abilities, and perceptions concerning union negotiating priorities and areas of conflict within the institutional environment. Of the 75 teachers contacted, 47 returned…

  13. Preoperative prism adaptation test in normosensoric strabismus

    Schildwächter-von Langenthal, Annette; Kommerell, Guntram; Klein, Ulrike; Simonsz, Huib

    1989-01-01

    textabstractIn 19 patients with normosensoric esotropia, the squint angles measured with the alternate cover test were compared with those after prolonged prismatic correction of the squint angle and with those after prolonged occlusion of one eye. All patients showed an increase of the squint angle after prism adaptation. The angle was generally smaller after diagnostic occlusion of one eye than after prism adaptation. We assume that the increase in the squint angle after prism adaptation is...

  14. Neutron forward diffraction by single crystal prisms

    Sohrab Abbas; Apoorva G Wagh; Markus Strobl; Wolfgang Treimer

    2008-11-01

    We have derived analytic expressions for the deflection as well as transmitted fraction of monochromatic neutrons forward diffracted by a single crystal prism. In the vicinity of a Bragg reflection, the neutron deflection deviates sharply from that for an amorphous prism, exhibiting three orders of magnitude greater sensitivity to the incidence angle. We have measured the variation of neutron deflection and transmission across a Bragg reflection, for several single crystal prisms. The results agree well with theory.

  15. Dispersion Compensation using a Prism-pair

    Shaked, Yaakov; Yefet, Shai; Pe'er, Avi

    2014-01-01

    A simple and intuitive formulation is reviewed for the Brewster prism-pair - A most common component in spectroscopy-oriented experiments using ultrashort pulses. This review aims to provide students and beginners in the field of spectroscopy with a unified description of a major experimental component. The total spectral phase experienced by a broadband light field is calculated after passing through a pair of Brewster-cut prisms, demonstrating the flexibility of the prism pair to provide tu...

  16. Persistance of HBsAg and serum activities of liver enzymes among chronic carriers of hepatitis B

    Mansoureh Momen-Heravi; Hossein Akbari

    2011-01-01

    Background: Hepatitis B virus (HBV) infection and its squeals are major global health problems. This study was conducted to evaluate HBsAg persistence, risk factors of HBV infection and changes of liver function tests among chronic HBV carriers in Kashan. Materials and Method: This descriptive study was performed in HBsAg positive blood donors who detected after blood donation since 10 years ago. They were requested to retest HBsAg. A questionnaire consisting demographic and history of risk ...

  17. Evaluating HBsAg rapid test performance for different biological samples from low and high infection rate settings & populations

    Cruz, Helena Medina; Scalioni, Leticia de Paula; de Paula, Vanessa Salete; da Silva, Elisangela Ferreira; do Ó, Kycia Maria Rodrigues; Milagres, Flavio Augusto Pádua; Cruz, Marcelo Santos; Bastos, Francisco Inácio; Pollo-Flores, Priscila; Leal, Erotildes; Motta-Castro, Ana Rita Coimbra; Pilotto, José Henrique; Lewis-Ximenez, Lia Laura; Lampe, Elisabeth; Villar, Livia Melo

    2015-01-01

    Background Rapid tests (RTs) might have several advantages over standard laboratory procedures, increasing access to diagnosis, especially among vulnerable populations and/or those living in remote areas. The aim of this study was to evaluate the performance of RTs for the detection of hepatitis B virus surface antigen (HBsAg) in samples from different populations/settings. Methods Three RTs for HBsAg detection (Vikia® HBsAg, HBsAg Teste Rápido®, and Imuno-Rápido HBsAg®) and different biologi...

  18. The PRISM/PRIME Project

    Lepton Flavour violation is predicted by many theories beyond the standard model. In the muon sector such a violation entails not only direct μ→eγ decay but also the conversion process μ→e. To measure this to high precision requires a large number of muons of very similar energy, and this is difficult to achieve from a muon target with conventional beam optics. PRISM is an FFAG system designed to accept large numbers of muons (1012/sec) with a wide range of energies, and render them monochromatic by accelerating the less energetic muons and decelerating the more energetic ones. To preserve Liouville's theorem, this is accompanied by a broadening in the timing of the muons, hence the name 'Phase Rotated Intense Slow Muon source.' The principles of this device have been demonstrated and components prototyped. PRIME is a detector (PRISM Muon Electron Conversion) which has been designed to stop 20 MeV bunches of muons in a thin foil, giving a very clean signal and reaching a background sensitivity of 10-18, four orders of magnitude better than today's limits and probing the interesting region for BSM theories.

  19. Effect of using heat-inactivated serum with the Abbott human T-cell lymphotropic virus type III antibody test.

    Jungkind, D. L.; DiRenzo, S A; Young, S J

    1986-01-01

    The Abbott enzyme immunoassay (Abbott Laboratories, North Chicago, Ill.) for human T-cell lymphotropic virus type III (HTLV-III) antibody was evaluated to determine the effect of using heat-inactivated (56 degrees C for 30 min) serum as the sample. Each of 58 nonreactive serum samples gave a higher A492 value when tested after heat inactivation. Ten of the samples became reactive after heating. Heat-inactivated serum should not be used in the current Abbott HTLV-III antibody test, because thi...

  20. A vaccine prepared from the 22 nm particles of surface hepatitis B antigen (HBsAg)

    A method for obtaining a subunit inactivated vaccine preparation from the 22-nm particles of HBsAg is proposed. For inactivation of the residual infectious hepatitis B virus (HBV) the preparations were successively treated with 1% sodium dodecyl sulfate (SDS) and nucleases. In addition, thermal denaturation and ultraviolet irradiation of HBV DNA were used. As a control the biologic activity of a reference virus (SV40) was tested after the same treatment. The effectiveness of DNA inactivation was monitored by adding 3H-thymidine labeled reference virus to the vaccine preparations. The purified and inactivated HBsAg was adsorbed on Al2O3. Antigenicity was calculated on the basis of the determination of antibody in guinea pigs immunized with various doses of the vaccine, and the release of 125I- HBsAg from blood and kidneys in immunized and control mice was analyzed. Possible methods of inactivation and control of HBV vaccine is discussed

  1. Kan vericilerde HBsAg, anti-HCV, anti-HIV ve Sifilis seroprevalansı

    Altındiş, Mustafa; Aslan, Savaş; Kalaycı, Raike

    2011-01-01

    Bu çalışmada Afyon Kocatepe Üniversitesi Tıp Fakültesi Kan Merkezi'ne başvuran donörlerde HBsAg, anti-HCV, anti-HIV 1/2 ve RPR seroprevalansının tespiti ve oranların yıllara ve cinsiyete göre dağılımının belirlenmesi amaçlanmıştır. Ocak'2001 ve Aralık'2010 tarihleri arasında Kan Merkezi'ne başvuran 37343 kan donörünün HBsAg, anti-HCV, anti-HIV ½ tarama testleri mikropartikül ELISA (Vitros, Ortho-Clinical Diagnostics) yöntemi ile Ortho-Clinical Diagnostics (HBsAg, HCV 3.jenerasyon, HIV 1/2) ki...

  2. PRISM: FFAG as a phase rotator

    PRISM is a project in Japan to make a high-intensity low-energy muon source with a narrow energy-spread and high purity. In this report, we present an overview of the PRISM project and its physics applications, especially to a search for muon lepton flavor violation. Its future extension towards a neutrino factory is also mentioned. (author)

  3. Association of social class in HBsAg and hepatocellular carcinoma

    Objective: To find out the social class difference in relation to frequency of HBsAg and hepatocellular carcinoma in our population. Design: An analytical study. Place and Duration of Study: This study was conducted in Oncology Department, Services Hospital, Lahore from December 1997 to December 2000. Subjects and Methods: The HBsAg positive voluntary and apparently healthy blood donors were grouped into three, based on monthly income. Lower socioeconomic group and had monthly income less than 3,000 Pakistani rupees, middle socioeconomic group had monthly income between 3,000-10,000 rupees and upper socioeconomic group had income of more than 10,000 Pakistani rupees. On the same pattern patients suffering from hepatocellular carcinoma coming for treatment were also grouped. During this period, 1000 blood donors were screened for HBsAg and 95 biopsy proven liver cancer by causes were treated. Medical and demographic data of all subjects were recorded. HBsAg test was performed immuno-chromatographic technique using Daina Screen HBsAg kit manufactured by Dainabot Co. Ltd, Tokyo, Japan. Results: Patients from lower and middle social class had higher percentage (80% and 75%) of hepatocellular carcinoma as compared to higher social class (66.6%). In the healthy asymptomatic blood donors lower social class had higher (13.76%) HBsAg positively as compared to middle social class (11.25%) and higher social class (8.06%). Conclusion: Preventive measures should be taken in identifying and reducing factors predisposing high frequency of these conditions. (author)

  4. Passive-active immunisation of neonates of HBsAg positive carrier mothers: preliminary observations.

    Mazel, J A; Schalm, S W; de Gast, B C; Nuijten, A S; Heijtink, R A; Botman, M J; Bänffer, J R; Gerards, L.J.; Zwijnenberg, J; Mettau, J

    1984-01-01

    Screening of pregnant women for hepatitis B surface antigen (HBsAg) in three areas of Holland led to the identification of HBsAg carriers, 20 of whom were subsequently delivered. Within two hours after birth all infants received hepatitis B immune globulin (0.5 ml/kg body weight) and, after randomisation, hepatitis B vaccine (10 micrograms) was given either at 0, 1, and 2 months of age or at 3, 4, and 5 months of age, the latter concomitantly with DPTP vaccination. Eighteen infants complying ...

  5. The Prism Plastic Calorimeter (PPC)

    2002-01-01

    This proposal supports two goals: \\\\ \\\\ First goal:~~Demonstrate that current, widely used plastic technologies allow to design Prism Plastic Calorimeter~(PPC) towers with a new ``liquid crystal'' type plastic called Vectra. It will be shown that this technique meets the requirements for a LHC calorimeter with warm liquids: safety, hermeticity, hadronic compensation, resolution and time response. \\\\ \\\\ Second goal:~~Describe how one can design a warm liquid calorimeter integrated into a LHC detector and to list the advantages of the PPC: low price, minimum of mechanical structures, minimum of dead space, easiness of mechanical assembly, accessibility to the electronics, possibility to recirculate the liquid. The absorber and the electronic being outside of the liquid and easily accessible, one has maximum flexibility to define them. \\\\ \\\\ The R&D program, we define here aims at showing the feasibility of these new ideas by building nine towers of twenty gaps and exposing them to electron and hadron beams.

  6. Clinical laboratory evaluation of the Abbott MS-2 automated antimicrobial susceptibility testing system: report of a collaborative study.

    Thornsberry, C; Anhalt, J P; Washington, J A; McCarthy, L R; Schoenknecht, F D; Sherris, J. C.; Spencer, H J

    1980-01-01

    The MS-2 system (Abbott Diagnostics, Division of Abbott Laboratories, Dallas, Tex.) was evaluated for its efficacy in determining the susceptibilities of both clinical and selected challenge (nonfastidious, facultative, and aerobic) isolates. The MS-2 results were compared with standard Kirby-Bauer disk diffusion and microdilution results by using fresh clinical isolates. For gram-positive isolates other than enterococci, overall agreement between MS-2 and reference results was 93 to 98%. Wit...

  7. Evaluation of the Abbott TESTPACK RSV enzyme immunoassay for detection of respiratory syncytial virus in nasopharyngeal swab specimens.

    Swierkosz, E M; Flanders, R; Melvin, L; Miller, J D; Kline, M W

    1989-01-01

    The Abbott TESTPACK RSV assay (Abbott Laboratories, North Chicago, Ill.), a rapid (20-min) enzyme immunoassay, was compared with culture and direct immunofluorescence (DFA) of nasopharyngeal cells for the detection of respiratory syncytial virus (RSV) in nasopharyngeal swab specimens. Nasopharyngeal swab specimens, collected from 234 infants, were placed in viral transport medium. Portions of specimen in transport medium were used for each test. Of 234 specimens, 70 (30%) were culture positiv...

  8. Abbott Wave-Triggered Runaway in Line-Driven Winds from Stars and Accretion Disks

    Feldmeier, Achim; Shlosman, Isaac

    2001-01-01

    Line-driven winds from stars and accretion disks are accelerated by scattering in numerous line transitions. The wind is believed to adopt a unique critical solution, out of the infinite variety of shallow and steep solutions. We study the inherent dynamics of the transition towards the critical wind. A new runaway wind mechanism is analyzed in terms of radiative-acoustic (Abbott) waves which are responsible for shaping the wind velocity law and fixing the mass loss. Three different flow type...

  9. Revisiting Abbott Thayer: non-scientific reflections about camouflage in art, war and zoology

    Behrens, Roy R.

    2008-01-01

    This paper reviews the achievements of Abbott Handerson Thayer (1849–1921), an American painter and naturalist whose pioneering writings on animal camouflage addressed shared concerns among artists, zoologists and military tacticians. It discusses his beliefs about camouflage (both natural and military) in the context of his training as an artist, with particular emphasis on three of his major ideas: countershading, ruptive (or disruptive) coloration and background picturing.

  10. Automation of the Limulus amoebocyte lysate test by using the Abbott MS-2 microbiology system.

    Jorgensen, J H; Alexander, G A

    1981-01-01

    A rapid, automated method for the performance of the Limulus amoebocyte lysate endotoxin assay has been developed by using the Abbott MS-2 Microbiology System. This instrument automatically determines sequential changes in the optical density of up to 176 samples at 1- or 5-min increments during a 1-h assay period. Graphic representation of optical density changes can be viewed on a cathode-ray tube or reproduced by using a hard-copy printer. Limulus amoebocyte lysate preparations that were o...

  11. Changes in risk factors of HBsAg positive blood donors in Zahedan, Iran

    Roya Alavi-Naini

    2011-07-01

    Full Text Available Background: Hepatitis B viral infection is a great global problem. According to high prevalence of infection in some parts of Iran, identifying etiologies and risk factors of the disease is an important issue in controlling infection in the community. The objective of this study is to compare the risk factors of HBsAg positive blood donors during a 10 year-period time-course.Materials and Method: We conducted a retrospective study in 1200 HBsAg positive blood donors referring to blood bank center in Zahedan during the years 1378, 1383 and 1387. Demographic variables and several risk factors were evaluated and compared during those years.Results: Our findings revealed significant statistical changes in age and education. Age was decreased and the disease was increased in illiterate cases during the study years. Risk factors that showed significant increasing changes during that time-period were history of dental procedures, surgery, hospitalization, endoscopy, positive family history for HBsAg, addiction to non-injectable drugs, living with positive HBsAg partners and intra-venous drug users. Conclusion: Decreasing the mean age of the patients during those years reflects increasing high risk behaviors among young people. Neonatal and family vaccination and screening family members, especially mothers could prevent this devastating disease. Following hygienic rules in the hospital is another important preventive measure. Premarital screening especially in high risk individuals is an effective preventive way to decrease the disease in the society.

  12. Demagnetizing effects in stacked rectangular prisms

    Christensen, Dennis; Nielsen, Kaspar Kirstein; Bahl, Christian Robert Haffenden;

    2011-01-01

    configuration, temperature distribution and applied magnetic field. In this paper the model is applied to the case of a stack of parallel, ferromagnetic rectangular prisms and the resulting internal field is found as a function of the orientation of the applied field, the number of prisms in the stack, the...... spacing between the prisms and the packing density of the stack. The results show that the resulting internal field is far from being equal to the applied field and that the various stack configurations investigated affect the resulting internal field significantly and non-linearly. The results have a...

  13. CHR(PRISM)-based probabilistic logic learning

    Sneyers, Jon; Meert, Wannes; Vennekens, Joost; Kameya, Yoshitaka; Sato, Taisuke

    2010-01-01

    PRISM is an extension of Prolog with probabilistic predicates and built-in support for expectation-maximization learning. Constraint Handling Rules (CHR) is a high-level programming language based on multi-headed multiset rewrite rules. In this paper, we introduce a new probabilistic logic formalism, called CHRiSM, based on a combination of CHR and PRISM. It can be used for high-level rapid prototyping of complex statistical models by means of "chance rules". The underlying PRISM system can t...

  14. A prism carbon molecule C$_20$

    OHNO, Koichi; Satoh, Hiroko; Iwamoto, Takeaki

    2015-01-01

    A new carbon family with a prism structure has been found by quantum chemical calculations. The prism-$C_20$ has a $D_10h$ structure with double-layered decagonal rings connected each other by ten vertical CC bonds. The CC bond lengths are 0.144 nm on the decagonal rings and 0.148 nm on the side faces. The diameter of the ring is 0.465 nm. The $prism-C_20$ is expected to be stable, since the lowest energy barrier from it was estimated to be 158.0 kJ mol$^−1$.

  15. Highly dispersive photonic band-gap prism

    We propose the concept of a photonic band-gap (PBG) prism based on two-dimensional PBG structures and realize it in the millimeter-wave spectral regime. We recognize the highly nonlinear dispersion of PBG materials near Brillouin zone edges and utilize the dispersion to achieve strong prism action. Such a PBG prism is very compact if operated in the optical regime, ∼20μm in size for λ∼700nm, and can serve as a dispersive element for building ultracompact miniature spectrometers. copyright 1996 Optical Society of America

  16. Highly dispersive photonic band-gap prism.

    Lin, S Y; Hietala, V M; Wang, L; Jones, E D

    1996-11-01

    We propose the concept of a photonic band-gap (PBG) prism based on two-dimensional PBG structures and realize it in the millimeter-wave spectral regime. We recognize the highly nonlinear dispersion of PBG materials near Brillouin zone edges and utilize the dispersion to achieve strong prism action. Such a PBG prism is very compact if operated in the optical regime, ~20 mm in size for lambda ~ 700 nm, and can serve as a dispersive element for building ultracompact miniature spectrometers. PMID:19881796

  17. A Study on HBsAg Carrier Rate of Children under Age Five in Danzhou City

    Bo Hu; Dui-Liu Li; Yuan-Gui Feng

    2015-01-01

    Objective:To learn the state of HBsAg carrier after implementing vaccine hepatitis B immunization program for children in Danzhou, and providing a scientific basis for the development of the hepatitis B vaccination strategies.Methods:A combination of stratified sampling and mechanical sampling method was carried out, the authors surveyed vaccine immunization history with hepatitis B in these children who were born from January 1, 2008 to December 31, 2012, then collected blood 3 mL and detected HBsAg carrier status by ELISA from these surveyed children.Results:250 children were included in the survey, the 24 h of birth Hepatitis B vaccine coverage rate in urban, rural newborns was 97.6% and 93.6%, respectively, hepatitis B vaccine three-pin vaccination rate for the whole vaccination course were 100%, only two children from rural area HBsAg carrier was positive, and their positive carrier rate was 0.8%, below 1%. Two HBsAg-positive carrier children from rural area and their families were under epidemiological survey, with discovery that their mothers were carriers of HBsAg, considered as mother to child transmission.Conclusions:Strengthen propaganda promotion to expand knowledge of Hepatitis B and to improve neonatal hepatitis B vaccine 24 h of the first dose timely rate, and standardize hepatitis B vaccine three-pin qualified vaccination rate for the whole vaccination course in children. Take effective measures to improve PMTCT rate, it can reduce child carrier rate of hepatitis B surface antigen, and take effective measures to improve PMTCT rates, it will reduce children carrier rate of HBsAg.

  18. 21 CFR 886.1650 - Ophthalmic bar prism.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ophthalmic bar prism. 886.1650 Section 886.1650...) MEDICAL DEVICES OPHTHALMIC DEVICES Diagnostic Devices § 886.1650 Ophthalmic bar prism. (a) Identification. An ophthalmic bar prism is a device that is a bar composed of fused prisms of gradually...

  19. Portable Remote Imaging Spectrometer (PRISM) Project

    National Aeronautics and Space Administration — Develop an UV-NIR (350nm to 1050 nm) portable remote imaging spectrometer (PRISM) for flight on a variety of airborne platforms with high SNR and response...

  20. Random prism: an alternative to random forests

    Stahl, F.; Bramer, Max

    2012-01-01

    Ensemble learning techniques generate multiple classifiers, so called base classifiers, whose combined classification results are used in order to increase the overall classification accuracy. In most ensemble classifiers the base classifiers are based on the Top Down Induction of Decision Trees (TDIDT) approach. However, an alternative approach for the induction of rule based classifiers is the Prism family of algorithms. Prism algorithms produce modular classification rules that do not nece...

  1. Pillars and pinning centers in superconducting prisms

    We solve the Ginzburg-Landau equations for to study the vortex configurations in a superconducting prism with a square array of pillars or holes in the presence of a uniform applied magnetic field. The presence of the pillars (holes) changes the vortex structures in the superconducting prism considerably. We calculate magnetization, free energy and vorticity curves, which shows the transition between different vortex configurations as a function of magnetic fields

  2. Recent studies on the PRISM FFAG ring

    Next generation lepton flavour violation experiments require high intensity and high quality muon beams. The PRISM Task Force focuses on accelerator R and D for realizing such beams using an FFAG ring. The scaling and non-scaling designs for the PRISM FFAG ring are discussed. The recent studies on injection/extraction systems and matching to the solenoid channel are outlined. The future plans for the study are presented.

  3. OPERA: Objective Prism Enhanced Reduction Algorithms

    Universidad Complutense de Madrid Astrophysics Research Group

    2015-09-01

    OPERA (Objective Prism Enhanced Reduction Algorithms) automatically analyzes astronomical images using the objective-prism (OP) technique to register thousands of low resolution spectra in large areas. It detects objects in an image, extracts one-dimensional spectra, and identifies the emission line feature. The main advantages of this method are: 1) to avoid subjectivity inherent to visual inspection used in past studies; and 2) the ability to obtain physical parameters without follow-up spectroscopy.

  4. Demagnetizing effects in stacked rectangular prisms

    A numerical, magnetostatic model of the internal magnetic field of a rectangular prism is extended to the case of a stack of rectangular prisms. The model enables the calculation of the spatially resolved, three-dimensional internal field in such a stack given any magnetic state function, stack configuration, temperature distribution and applied magnetic field. In this paper the model is applied to the case of a stack of parallel, ferromagnetic rectangular prisms and the resulting internal field is found as a function of the orientation of the applied field, the number of prisms in the stack, the spacing between the prisms and the packing density of the stack. The results show that the resulting internal field is far from being equal to the applied field and that the various stack configurations investigated affect the resulting internal field significantly and non-linearly. The results have a direct impact on the design of, e.g., active magnetic regenerators made of stacked rectangular prisms in terms of optimizing the internal field.

  5. Neutron energy analysis by silicon prisms

    Neutron energy analysing by refraction with prisms allows to measure different wavelengths at the same time thus avoiding losses due to monochromatization. We built and tested a refractive energy analysing device made from small prisms, where losses only occur due to the attenuation in the material. We measured the refraction and the transmission of MgF2 and Si prisms at the V14 reflectometer in Berlin at 4.9 Å to check their applicability. The experimentally determined linear attenuation coefficients are 0.055 cm−1 for the MgF2 and 0.03 cm−1 for the Si prisms. An energy analyser consisting of silicon prism layers was measured at the EROS reflectometer at the LLB in a white neutron beam. The useful wavelength band was 2.4–7.6 Å. At 6.7 Å a wavelength resolution of 5% and a transmission of 53% were achieved. The surface roughness of the prisms could be determined to be (0.011±0.006)deg

  6. Neutron energy analysis by silicon prisms

    Schulz, J., E-mail: jennifer.schulz@helmholtz-berlin.de [Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, 14109 Berlin (Germany); Ott, F. [Laboratoire Leon Brillouin, Bât 563 CEA Saclay, 91191 Gif sur Yvette Cedex (France); Hülsen, Ch.; Krist, Th. [Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, 14109 Berlin (Germany)

    2013-11-21

    Neutron energy analysing by refraction with prisms allows to measure different wavelengths at the same time thus avoiding losses due to monochromatization. We built and tested a refractive energy analysing device made from small prisms, where losses only occur due to the attenuation in the material. We measured the refraction and the transmission of MgF{sub 2} and Si prisms at the V14 reflectometer in Berlin at 4.9 Å to check their applicability. The experimentally determined linear attenuation coefficients are 0.055 cm{sup −1} for the MgF{sub 2} and 0.03 cm{sup −1} for the Si prisms. An energy analyser consisting of silicon prism layers was measured at the EROS reflectometer at the LLB in a white neutron beam. The useful wavelength band was 2.4–7.6 Å. At 6.7 Å a wavelength resolution of 5% and a transmission of 53% were achieved. The surface roughness of the prisms could be determined to be (0.011±0.006)deg.

  7. Frekuensi HBsAg Positif pada Uji Saring Darah di Palang Merah Indonesia Cabang Padang Tahun 2012

    Nadia Ventiani

    2015-09-01

    Full Text Available Abstrak Infeksi virus hepatitis B dapat berkembang menjadi hepatitis kronis, sirosis hati, kanker hati dan bahkan kematian. Salah satu cara penularannya adalah melalui transfusi darah. Tujuan penelitian ini adalah untuk mengetahuifrekuensi HBsAg positif pada uji saring darah donor.  Telah dilakukan penelitian deskriptif dengan menggunakan datasekunder di PMI Padang dengan 26.975 darah donor yang diteliti. Donor laki-laki lebih banyak dari donor perempuandengan perbandingan 11,69:1, dan pendonor sukarela lebih banyak dari pendonor pengganti, dengan perbandingan2,95:1. Pendonor terbanyak terdapat pada kelompok usia dibawah 30 tahun, yaitu sebanyak 38,09%. Hasil penelitianmenunjukan persentase darah donor dengan HBsAg positif sebesar 3,61%. Pendonor laki-laki dengan HBsAg positifsebesar 93,22%, perempuan 6,78% dan pendonor sukarela sebesar 65,09%, pendonor pengganti sebesar 34,91%.Hasil HBsAg positif terbanyak terdapat pada kelompok usia dibawah 30 tahun sebesar 39,01%. Sebagian besar darahdonor yang mengandung HBsAg positif terdapat pada kelompok umur di bawah 30 tahun. Frekuensi HBsAg positif lebih banyak pada donor laki-laki dibanding donor perempuan, dan donor sukarela dengan HBsAg positif lebih banyak dibanding donor pengganti.Kata kunci: HBsAg, donor darah, transfusi darahAbstract Hepatitis B virus infection could progress into chronic hepatitis, liver cirrhosis, liver cancer and even death. One mode of transmission is via blood transfusion. The objective of this study was to determine the frequency of positive HBsAg in the screening test of the blood donors. A descriptive studies has been conducted by using secondary datasin  PMI Padang. There were 26975 blood donors studied that  men donors were higher than female donors, with the number ratio of male and female were 11.69:1, and the number of voluntary donors were higher compared to the replacement donors, with ratio 2.95:1. Most of the donors were in the age group below 30 years, which

  8. Significance of tests for HBeAg and anti-HBe in HBsAg positive blood donors.

    Dow, B C; Macvarish, I; Barr, A.; Crawford, R J; Mitchell, R.

    1980-01-01

    A sensitive radioimmunoassay method for HBeAg and anti-HBe allowed 98.4% of HBsAg positive blood donors to be classified. HBeAg was more prevalent in blood donors under 30 years of age and anti-HBe was more prevalent in those over 30 years. The mean HBsAg concentration was four times greater in donors with HBeAg than in those with anti-HBe. No significant associations were found with sex, blood groups, or HBsAg subtypes. It is likely that this test system will be extremely useful to blood tra...

  9. A portable direct view configuration prism spectrometer using a double Amici prism

    Sun, Lanjun; Zhang, Yanchao; Tian, Zhaoshuo; Ren, Xiuyun; Fu, Shiyou

    2015-10-01

    In this paper, we present a prism spectrometer that exploits a double Amici prism dispersion structure. The system consists of a slit, a collimating lens, a double Amici prism, an imaging lens and a CCD. The incident light enter into slit, and then is paralleled by a collimating lens to the double Amici prism. The double Amici prism is used to realize spectral dispersion. The dispersed light is collected by an imaging lens and image on the photosensitive surface of the CCD. The dispersion resolution is theoretical analyzed from the ray tracing point of view. In addition, the imaging position on CCD element at different wavelength is presented according to nonlinear curve of dispersion. The designed prism spectrometer can obtain a high light throughput and less optical distortion spectrum in the spectral range of 370-700nm. In experiment, we measured the spectral resolution of the designed prism spectrometer at five wavelength used a grating monochromator. The designed in-line, direct view configuration prism spectrometer owns the advantages of high light throughput, less optical distortions, compact structure, small volume and easy operation, which has important role in application of laser spectral measurement especially laser remote sensing spectral detection.

  10. Long-term persistence of T cell memory to HBsAg after hepatitis B vaccination

    Ru-Xiang Wang; Greet J. Boland; Jan van Hattum; Gijsbert C. de Gast

    2004-01-01

    AIM: To determine if the T cell memory to HBsAg can persist for a long time after hepatitis B (HB) vaccination.METHODS: Thirty one vaccine recipients who were healthcare workers (18 females and 13 males aged 34-58 years) from Utrecht University Hospital, Netherlands, and had previously Received a standard course of vaccination for hepatitis B were investigated and another 9 unvaccinated healthy volunteers from the same hospital were used as the control. Blood samples were taken just before the experiment to test serum anti-HBs levels and the subjects were classified into different groups according to their serum titers of anti-HBs and vaccination history. Their peripheral blood mononuclear cells (pBrvMc) were isolated from freshly heparinized venous blood and the proliferative response of Tlymphocytes to the recombinant hepatitis B surface antigen(HBsAg) was investigated.RESULTS: Positive serum anti-HBs was found in 61.3%(19/31) vaccine recipients and a significant in vitro lymphocyte proliferative response to recombinant HBsAg was observed in all the vaccinees with positive anti-HBs. Serum anti-HBs level ≤10 IU/L was found in 38.7% (12/31)subjects. In this study, we specially focused on lymphocyte proliferative response to recombinant HBsAg in those vaccine recipients with serum anti-HBsAg less than 10 IU/L.Most of them had Received a standard course of vaccination about 10 years before. T lymphocyte proliferative response was found positive in 7 of the 12 vaccine recipients. These results confirmed that HBsAg-specific memory T cells remained detectable in the circulation for a long time after vaccination, even when serum anti-HBs level had been undetectable.CONCLUSION: The T cell memory to HBsAg can persist for at least 10 years after HB vaccination. Further booster injection is not necessary in healthy responders to HB vaccine.

  11. Oral immunization of animals with transgenic cherry tomatillo expressing HBsAg

    Yi Gao; Yina Ma; Mei Li; Tonq Chenq; Shao-Wei Li; Jun Zhang; Ning-Shao Xia

    2003-01-01

    AIM: To investigate the expression of recombinant HBsAg (rHBsAg) in transgenic cherry tomatillo in order to explore the feasibility of producing HBV oral vaccine with cherry tomatillo by animal immune tests.METHODS: The recombinant plant expression vector containing HBsAg gene was constructed. Mediated with Agrobacterium tumefaciens, HBsAg gene was transferred into cotyledons of cherry tomatillo. Transformed cherry tomatillos were obtained through hygromycin delay-selection. Integrated DNA in transgenic cherry tomatillo was confirmed by hygromycin resistance selection, Gus detection, polymerase chain reaction (PCR) and dot blotting analysis. Antigenicity of rHBsAg was examined by ELISA and the immunogenicity of rHBsAg derived from transgenic cherry tomatillo tissues was confirmed by oral feed of transformed tissues to BALB/c mice primed with commercial HBV vaccines. Specific antibody titers in mice's serum were examined by ELISA every week.RESULTS: By far, 10 positive lines of transgenic cherry tomatillos containing HBsAg gene were obtained. Among different organs of the same transgenic cherry tomatillo,level of rHBsAg expressed in leaves was the highest with the yield up to 300ng/g fresh weight. And the rHBsAg expression level in fruits was about 10 ng/g fresh weight.In animal immune tests, oral delivery with transgenic tissues to mice primed with commercial vaccine instead of naive mice resulted in significant immune response.CONCLUSION: The result of this animal immune test indicated the rHBsAg derived from transgenic cherry tomatillo possessed normal immunogenicity. This work demonstrated the feasibility to generate oral immunogenic rHBsAg in transgenic cherry tomatillo, and would provide some experimental approach for the production of low-cost oral vaccines using transgenic cherry tomatillo in large scale.

  12. Transgenic lettuce seedlings carrying hepatitis B virus antigen HBsAg

    Jackson Marcondes; Ekkehard Hansen

    2008-01-01

    The obtainment of transgenic edible plants carrying recombinant antigens is a desired issue in search for economic alternatives viewing vaccine production. Here we report a strategy for genetic transformation of lettuce plants (Lactuca sativa L.) using the surface antigen HBsAg of hepatitis B virus. Transgenic lettuce seedlings were obtained through the application of a regulated balance of plant growth regulators. Genetic transformation process was acquired by cocultivation of cotyledons wit...

  13. Subsurface damage distribution characterization of ground surfaces using Abbott-Firestone curves

    Measurement of subsurface damage (SSD) induced by grinding process is of major interest in the development of high laser damage fused silica optical components manufacturing processes. Most SSD measurements methods give only access to the peak to peak value. We herein report on the benefit of using Abbott-Firestone curves to get an insight of the SSD distribution inside the optical material. We evidence on various diamond wheel ground fused silica substrates that such an approach is complementary to a classical SSD peak to peak measurement and bring useful information to optimize a grinding process. (authors)

  14. Quantitation of human chorionic gonadotropin with the Abbott IMx immunochemistry analyzer.

    van Oers, R J; Leerkes, B; Bertschi, I

    1990-01-01

    The analytical performance of the Abbott IMx automated system was studied and initial results from the human chorionic gonadotropin assay are presented: Within run and between day precision was good, the majority of all CVs lying between 3 and 5%; Patient results showed excellent comparability with our routine method; No significant specimen-related carry-over was detected; The automated IMx dilution protocol was found to be superior to the manual procedure; The usefulness of the instrument in routine use and as a "Stat" analyzer was very good. PMID:2179460

  15. Prevalence of HBsAg Positive among Afghan Sweepers in Tehran, 2009

    Seyed Mohammad Javad Hosseini

    2013-07-01

    Full Text Available AbstractBackground and objective: Hepatitis B virus is one of the great public health problems all over the world. Moreover prevalence of Hepatitis B in Iran is near 1.5 million (2.03% of general population. The objective of this study was to determine the prevalence of Hepatitis B among Afghan sweepers in 2, 5 and 9 municipal areas of Tehran in 2009.Materials and methods: This was a cross-sectional study on 250 afghan sweeper in 2, 5 and 9 municipal areas of Tehran. Demographic form including age, duration of working and migration, history of sexual contacts, needle stick injury, IV drug abuse, surgery and blood transfusion was completed for all cases. The blood samples were collected and examined for HBsAg by Eliza test at Iran Blood transfusion organization laboratory.Results: From 250 Afghan sweepers enrolled in this study, HBsAg positive was detected in 10 (4% cases. We found significant relation between the HBsAg positive, needle stick injury, unprotected sexual contact, age and time migration to Iran (P<0.05.Conclusion: Prevalence of Hepatitis B was approximately high among afghan sweeper in Tehran. The results indicated that prevalence of risk factors like needle stick injury and unprotected sexual contact were high among Afghan sweepers. Educations of Hepatitis B, ways of transmission, screening of infectious disease, and other blood-born infection to sweepers are important.

  16. European collaborative evaluation of Enzygnost HBsAg 6.0: performance on hepatitis B virus surface antigen variants

    Avellón, Ana; Echevarría, Jose-Manuel; Weber, Bernard; Weik, Michael; Schobel, Uwe-Peter; Willems, Wulf R.; Gerlich, Wolfram

    2010-01-01

    Abstract Amino acid changes within the major antigenic determinant of the hepatitis B virus (HBV) surface antigen (HBsAg) may eventually modify the antigenic properties of the protein and may have impact on the sensitivity of diagnostic assays. Modifications in the design of an assay can, however, improve significantly its capability to detect these mutants. One-hundred and forty-seven clinical samples containing HBsAg variants, and 54 supernatants of cells expressing recombinant H...

  17. PATTERN OF HBsAg POSITIVITY IN SELECTED GROUPS AT KING KHALID GENERAL HOSPITAL - HAIL REGION, KINGDOM OF SAUDI ARABIA

    Mahaba, Hisham M.; El-Tayeb, Abd El Kader A.; El-Sekibi, Dahl K; El Gofaei, Ali F.; El-Baz, Hisham S.; Ismail, Nanees A.

    1997-01-01

    Background: Hepatitis B virus (HBV) is endemic in the Kingdom of Saudi Arabia. The acquisition of infection occurs early in life. The availability of safe and efficacious vaccines has led to the feasibility of an effective control of HBV infection. This study compares the pattern of HBsAg positivity among selected groups of patients with similar groups in other regions in the Kingdom of Saudi Arabia. Objectives: This study is conducted to determine the prevalence of HBsAg positive subjects am...

  18. A Intervention Study to Improve HBsAg Testing and Preventive Practices for Hepatitis B in an Obstetrics Hospital

    Ibrahim Koruk

    2011-06-01

    Full Text Available Objectives: This study was conducted to determine the effectiveness of a multicomponent intervention in Sanliurfa Gynecology and Obstetrics Hospital (SGOH, which is designed to overcome the obstacles encountered in the application of HBsAg testing to all delivering women, the administration of hepatitis B vaccine and Hepatitis B Immunglobulin(HBIG to newborns of HBsAg positive pregnant women. Methods: This is an intervention study, conducted between December 15, 2007 and December 30, 2008. Intervention procedure is composed of four methods; namely, motivation of all parties through academic leadership, implementation of workshops to determine the obstacles, provision of administrative commitment, and training of healthcare personnel. Results: In 2007, a total of 18,709 deliveries were realized in SGOH; HBsAg testing was performed in only 16.5% of the pregnant women and 0.8% of these women were found to be HBsAg positive. It was determined that HBIG was administered to 28.2% of newborns of HBsAg positive mothers and hepatitis B vaccine was given to 71.4% (n=13349 of all newborns. After the intervention, the increase in HBsAg test application status, HBsAg positivity, HIBG administration and hepatitis B vaccination was 6.0, 5.8, 2.0 and 1.2 fold, respectively (P<0.05. Conclusions: In order to reduce the incidence of hepatitis B and maintain patient safety in newborns, HBsAg testing should be included in routine pregnancy screening programs and this approach should be supported by legal arrangements and systematic continuous training activities. [TAF Prev Med Bull 2011; 10(3.000: 287-292

  19. An improved prism energy analyzer for neutrons

    The effects of two improvements of an existing neutron energy analyzer consisting of stacked silicon prism rows are presented. First we tested the effect of coating the back of the prism rows with an absorbing layer to suppress neutron scattering by total reflection and by refraction at small angles. Experiments at HZB showed that this works perfectly. Second the prism rows were bent to shift the transmitted wavelength band to larger wavelengths. At HZB we showed that bending increased the transmission of neutrons with a wavelength of 4.9 Å. Experiments with a white beam at the EROS reflectometer at LLB showed that bending of the energy analyzing device to a radius of 7.9 m allows to shift the transmitted wavelength band from 0 to 9 Å to 2 to 16 Å

  20. An improved prism energy analyzer for neutrons

    Schulz, J., E-mail: jennifer.schulz@helmholtz-berlin.de [Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, 14109 Berlin (Germany); Ott, F. [Laboratoire Leon Brillouin, Bât 563 CEA Saclay, 91191 Gif sur Yvette Cedex (France); Krist, Th. [Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, 14109 Berlin (Germany)

    2014-04-21

    The effects of two improvements of an existing neutron energy analyzer consisting of stacked silicon prism rows are presented. First we tested the effect of coating the back of the prism rows with an absorbing layer to suppress neutron scattering by total reflection and by refraction at small angles. Experiments at HZB showed that this works perfectly. Second the prism rows were bent to shift the transmitted wavelength band to larger wavelengths. At HZB we showed that bending increased the transmission of neutrons with a wavelength of 4.9 Å. Experiments with a white beam at the EROS reflectometer at LLB showed that bending of the energy analyzing device to a radius of 7.9 m allows to shift the transmitted wavelength band from 0 to 9 Å to 2 to 16 Å.

  1. Detection of HBsAg, HBcAg, and HBV DNA in ovarian tissues from patients with HBV infection

    Li-Zhang Chen; Xue-Gong Fan; Jian-Ming Gao

    2005-01-01

    AIM: To investigate the presence of HBsAg, HBcAg, and HBV DNA in ovarian tissues from patients with HBV infection.METHODS: HBsAg and HBcAg were examined in ovarian biopsy tissues from 26 patients with HBV infection by immunocytochemistry, and HBV DNA was detected in ovarian tissues by PCR.RESULTS: HBsAg and HBcAg were present with the same positive rate of 34.6% (9/26). The total positive rate was 46.2% (12/26). HBsAg and HBcAg were positive in 6 (23.1%) of the 26 patients. Brown positive particles were diffusely distributed in ovarian cells. The positive rate of HBV DNA was 58.3% (7/12).CONCLUSION: HBsAg, HBcAg, and HBV DNA can be detected in ovarian tissues from patients with HBV infection. The presence of HBsAg and HBcAg in ovarian tissues does not correlate with the HBV markers in serum.

  2. Multicenter evaluation of the new Abbott Realtime assays for quantitative detection of human immunodeficiency virus type 1 and hepatitis C virus RNA

    M. Schutten (Martin); D. Peters (D.); N. Back (Nicole); A.W. van den Beld (Annewieke); B. Beuselinck (B.); V. Foulongne (V.); A.M. Geretti (Anna Maria); L. Pandiani (L.); M. Tiemann; H.G.M. Niesters (Bert)

    2007-01-01

    textabstractThe analytical performances of the new Abbott RealTime hepatitis C virus (HCV) and human immunodeficiency virus type 1 viral load assays were compared at nine laboratories with different competitor assays. These included the Abbott LcX, Bayer Versant bDNA, Roche COBAS Amplicor, and Roche

  3. Multicenter evaluation of the new Abbott RealTime assays for quantitative detection of human immunodeficiency virus type 1 and hepatitis C virus RNA

    Schutten, M; Peters, D; Back, N K T; Beld, M; Beuselinck, K; Foulongne, V; Geretti, A-M; Pandiani, L; Tiemann, C; Niesters, H G M

    2007-01-01

    The analytical performances of the new Abbott RealTime hepatitis C virus (HCV) and human immunodeficiency virus type 1 viral load assays were compared at nine laboratories with different competitor assays. These included the Abbott LcX, Bayer Versant bDNA, Roche COBAS Amplicor, and Roche COBAS TaqMa

  4. Abbott Wave-Triggered Runaway in Line-Driven Winds from Stars and Accretion Disks

    Feldmeier, A; Feldmeier, Achim; Shlosman, Isaac

    2001-01-01

    Line-driven winds from stars and accretion disks are accelerated by scattering in numerous line transitions. The wind is believed to adopt a unique critical solution, out of the infinite variety of shallow and steep solutions. We study the inherent dynamics of the transition towards the critical wind. A new runaway wind mechanism is analyzed in terms of radiative-acoustic (Abbott) waves which are responsible for shaping the wind velocity law and fixing the mass loss. Three different flow types result, depending on the location of perturbations. First, if the shallow solution is perturbed sufficiently far downstream, a single critical point forms in the flow, which is a barrier for Abbott waves, and the solution tends to the critical one. Second, if the shallow solution is perturbed upstream from this critical point, mass overloading results, and the critical point is shifted inwards. This wind exhibits a broad, stationary region of decelerating flow and its velocity law has kinks. Third, for perturbations eve...

  5. Development of the Abbott MATRIX Aero assay for the measurement of specific IgE.

    Lindberg, R E; Anawis, M A; Bailey, M; Mangat, D; Frank, P M; Hrusovsky, I G; Hooyman, L; Putterman, C; Defreese, J D

    1991-01-01

    An enzyme immunoassay has been developed for the quantitation of specific immunoglobulin E (IgE) in human serum to a panel of allergens. The assay system, called the Abbott MATRIX Aero, includes an instrument, reagents and test cell disposables. Each test cell contains fourteen airborne allergens individually localized on a nitrocellulose solid phase. Individual calibration curves for each allergen are established by the manufacturer and included in barcode form with each test kit. Stable factory calibration eliminates the need to establish a calibration curve with each assay run. The instrument automatically incubates, washes, and reads the test cell and prints each result, which ensures assay reproducibility and provides ease-of-use. Analysis of test results shows good agreement with another in vitro assay for specific IgE. The Abbott MATRIX Aero is a sensitive, reproducible and easy-to-use system for the measurement of specific IgE to a panel of fourteen allergens simultaneously using a single, small volume of serum. PMID:1806584

  6. Fresnel Prism on Hess Screen Test

    Kyung Min Koh; Ungsoo Samuel Kim

    2013-01-01

    A 65-year-old male patient complained of diplopia after a cataract surgery. He had esotropia of 18 prism diopters (PDs) at distant and near deviation, and therefore, we performed the Hess screen test to identify any abnormal eye movement. However, the indicator was found to be out of bounds, and therefore, the test could not be completed. Therefore, the test was subsequently performed with a 20 PD base-out Fresnel prism, and an abduction deficit was observed in the right eye, but not in the l...

  7. Symmetry Breaking Analysis of Prism Adaptation's Latent Aftereffect

    Frank, Till D.; Blau, Julia J. C.; Turvey, Michael T.

    2012-01-01

    The effect of prism adaptation on movement is typically reduced when the movement at test (prisms off) differs on some dimension from the movement at training (prisms on). Some adaptation is latent, however, and only revealed through further testing in which the movement at training is fully reinstated. Applying a nonlinear attractor dynamic model…

  8. 21 CFR 886.1655 - Ophthalmic Fresnel prism.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ophthalmic Fresnel prism. 886.1655 Section 886...) MEDICAL DEVICES OPHTHALMIC DEVICES Diagnostic Devices § 886.1655 Ophthalmic Fresnel prism. (a) Identification. An ophthalmic Fresnel prism is a device that is a thin plastic sheet with embossed rulings...

  9. 21 CFR 886.1665 - Ophthalmic rotary prism.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ophthalmic rotary prism. 886.1665 Section 886.1665...) MEDICAL DEVICES OPHTHALMIC DEVICES Diagnostic Devices § 886.1665 Ophthalmic rotary prism. (a) Identification. An ophthalmic rotary prism is a device with various prismatic powers intended to be handheld...

  10. 21 CFR 886.5810 - Ophthalmic prism reader.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ophthalmic prism reader. 886.5810 Section 886.5810...) MEDICAL DEVICES OPHTHALMIC DEVICES Therapeutic Devices § 886.5810 Ophthalmic prism reader. (a) Identification. An ophthalmic prism reader is a device intended for use by a patient who is in a supine...

  11. Comparing the Volumes of Rectangular Prisms

    Assuah, Charles K.; Wiest, Lynda R.

    2010-01-01

    Can middle-grades students determine which of two rectangular prisms has a larger volume? Can they do so without using a formula? Geometry, and particularly the concept of volume, is important in many subjects, such as physics and chemistry. Students greatly enhance their mathematics knowledge when they make generalizations and construct arguments…

  12. Prisms Throw Light on Developmental Disorders

    Brookes, Rebecca L.; Nicolson, Roderick I.; Fawcett, Angela J.

    2007-01-01

    Prism adaptation, in which the participant adapts to prismatic glasses that deflect vision laterally, is a specific test of cerebellar function. Fourteen dyslexic children (mean age 13.5 years); 14 children with developmental coordination disorder (DCD): 6 of whom had comorbid dyslexia; and 12 control children matched for age and IQ underwent…

  13. Dispersion Compensation with a Prism-pair

    Shaked, Yaakov; Pe'er, Avi

    2014-01-01

    We present a detailed calculation of the total dispersion (spectral phase) from a pair of Brewster-cut prisms. This paper aims to aid advanced students in tracking the operation of this major configuration for dispersion-compensation and phase-control of ultra-short pulses.

  14. CHR(PRISM)-based Probabilistic Logic Learning

    Sneyers, Jon; Vennekens, Joost; Kameya, Yoshitaka; Sato, Taisuke; 10.1017/S1471068410000207

    2010-01-01

    PRISM is an extension of Prolog with probabilistic predicates and built-in support for expectation-maximization learning. Constraint Handling Rules (CHR) is a high-level programming language based on multi-headed multiset rewrite rules. In this paper, we introduce a new probabilistic logic formalism, called CHRiSM, based on a combination of CHR and PRISM. It can be used for high-level rapid prototyping of complex statistical models by means of "chance rules". The underlying PRISM system can then be used for several probabilistic inference tasks, including probability computation and parameter learning. We define the CHRiSM language in terms of syntax and operational semantics, and illustrate it with examples. We define the notion of ambiguous programs and define a distribution semantics for unambiguous programs. Next, we describe an implementation of CHRiSM, based on CHR(PRISM). We discuss the relation between CHRiSM and other probabilistic logic programming languages, in particular PCHR. Finally we identify ...

  15. Prevalence of Hepatitis B surface antigen (HBsAg among visitors of Shashemene General Hospital voluntary counseling and testing center

    Medhin Girmay

    2011-02-01

    Full Text Available Abstract Background Hepatitis B virus (HBV infection is significant health problem, as it can lead to chronic hepatitis, liver cirrhosis, and hepatic carcinoma. Due to shared routes of transmission, HBV and human immunodeficiency virus (HIV co-infection is common and is an emerging concern in the clinical management of patients because of increased mortality, accelerated hepatic disease progression, and the frequent hepatotoxicity caused by anti-retroviral therapy. The aim of this study was to determine the prevalence of Hepatitis B surface antigen (HBsAg and its risk factors, among individuals visiting Shashemene General Hospital VCT center. Findings Institution based cross-sectional study was performed from November 3, 2008 to December 29, 2008 and 384 voluntary counseling and testing (VCT clients were investigated. Data on socio demographic and HBV risk factors was collected using structured questionnaires. Blood samples were collected and screened for hepatitis B surface antigen (HBsAg and HIV by commercially available rapid test kits. The prevalence of HBsAg in this study group was 5.7%. Fourteen percent of HIV positive subjects (8/57 and 4.3% (14/327 of HIV negative subjects were positive for HBsAg. Significantly high prevalence of HBsAg was observed among individuals who had history of invasive procedures, like tooth extraction, abortion and ear piercing; history of hospital admission, history of unsafe inject and HIV positives. Conclusions Although HBsAg prevalence is much higher among subjects who are HIV positive (14.0% versus 4.3%, the prevalence of HBsAg in HIV negative subjects is high enough to warrant a recommendation to screen all clients at VCT centers irrespective of HIV status.

  16. Seropositivity of HBsAg, anti-HCV and anti-HIV in preoperative patients

    Berrin Karaayak Uzun

    2014-12-01

    Full Text Available Objective: The infections caused by human immunodeficiency virus (HIV, hepatitis B (HBV and C (HCV viruses pose a serious occupational risk for the healthcare workers especially those in emergency services, laboratories and surgery wards. Vaccination and establishment of the strict biosafety procedures are the main principles to prevent blood-borne infections in healthcare workers. Additionally, serological screening of the preoperative patients could decrease the risk for exposure. In this study, we aimed to determine the seroprevalence of HBsAg, anti-HCV, anti-HIV 1/2 in preoperative patients. Methods: Hospital automation records were evaluated retrospectively for 4.367 patients who were scheduled for surgery and scanned for anti-HIV 1/2, HBsAg and anti-HCV as preoperative procedures in the preparation period of operation between January 2012 and December 2012. Results: HBsAg positivity rate was found in 7.7% (n=336, anti-HCV positivity rate was found in 2.3% (n=101. A two (0.05% of five patients were positive for anti-HIV 1/2 was found positive verification test and the other three samples were accepted as false positive test results. Conclusion: All healthcare workers must be trained about occupational diseases and vaccinated against Hepatitis B. Universal precautions must be strictly followed particularly in the operating room. In addition, all patients should be considered as potential carriers regarded as a carrier of the potential for infection. J Clin Exp Invest 2013; 4 (4: 449-452

  17. Serological profile of incidentally detected asymptomatic HBsAg positive subjects (IDAHS)

    Objective: To evaluate the serological profile of patients with incidentally detected positive hepatitis-B surface antigen (HBsAg) and to asses the risk factors. Design: An observational study. Place and Duration of Study: This study was conducted at Shifa International Hospital, Islamabad from 1999 to 2003. Patients and Methods: All patients who presented to gastroenterology clinic of Shifa Intentional Hospital, Islamabad with positive HBsAg, detected incidentally, were tested for alamine transaminase (ALT), hepatitis Beantigen (HBeAg) and in certain cases hepatitis-B virus DNA (HBV DNA) by polymerase chain reaction (PCR). Their risk factors for acquisition of infection were assessed with specific questions. Results: A total of 224 patients were examined. One hundred sixty-four (73.2%) were male and 60 (26.8%) female. Mean age of all the subjects was 32.45 plus minus 11.85 years. Out of 224 patients, 48 (21.4%) were positive for HBeAg and 176 (78.6%) were negative. Out of 48 subjects who were positive for HBeAg, 36 underwent HBV DNA determination and 32 (88.8%) were positive for HBV DNA. Out of 176 subjects who had negative HBeAg, 46 had elevated ALT and in those HBV DNA was performed and 14 had positive HBV DNA. Most common risk factors detected in these patients were intramuscular injections and surgery, however, in a large number, risk factors were unknown. Conclusion: Twenty-one percent asymptomatic subjects with positive HBsAg were found to be HBeAg positive. A large number of subjects with negative HBeAg had HBV DNA positive suggesting presence of precore mutants. Intramuscular injections and surgery were noted to be frequent risk factors in these subjects. (author)

  18. Expression of Hepatitis B virus surface antigen (HBsAg from genotypes A, D and F and influence of amino acid variations related or not to genotypes on HBsAg detection

    Natalia M. Araujo

    2009-08-01

    Full Text Available The impact of hepatitis B virus (HBV genotypes on the sensitivity of surface antigen (HBsAg detection assays has been poorly investigated. Here, plasmids carrying consensus or variant coding sequences for HBV surface proteins from genotypes A, D and F, were constructed. HBsAg levels were evaluated in medium and extracts of transfected CHO cells by a commercial polyclonal-based assay. We show that HBsAg detection values of consensus forms from genotypes D and F were, respectively, 37% and 30% lower than those obtained by genotype A. However, the presence of two single variations, T143M in genotype A, and T125M in genotype D, produced a decrease of 44% and an increase of 34%, respectively, on HBsAg mean values in comparison with their consensus forms. In conclusion, HBsAg detection levels varied among HBV genotypes. However, unique amino acid substitutions not linked to genotypes, such as T125M and T143M described here, should have more implications in HBV immunological diagnostics than the set of variations characteristic of each HBV genotype.

  19. Serological markers of hepatitis B infection in incidentally detected HBsAg positive patients

    To evaluate the serological profile of the incidentally detected HBsAg positive patients, to asses the severity of disease and to identify the risk factors for the transmission. an observational study. All patients who presented to gastroenterology clinic of Bolan Medical Complex hospital Quetta and at few private clinics with positive HbsAg, detected incidentally, were tested for alamine transaminase (ALT), hepatitis Be antigen (HbeAg) anti. HBe antibody and hepatitis-B virus DNA (HBV DNA) by polymerase chain reaction (PCR). Their risk factors for acquisition of infection were assessed with specific questions. A total of one hundred and four (104) patients with HBsAg reactive were included, 89 were male and 15 were females. The mean age was 30 years, with minimum age of 07 years and maximum of 57 year. Out of 104 patients, 93 patients were for HbeAg, 14 (15%) were positive for HBeAg and 79 (85%) were negative. Anti HBe antibody was checked in 91 patients, and it was reactive in 72 (79%), while it was non-reactive in only 19(21%) patients. HBV DNA (qualitative) determination was done in 95 patients and it was detected in 11(11.6%) ana 84 (88.4%) were negative for HBV DNA. No significant correlation is seen between seroconversion and AL T levels. Normal AL T levels were observed only in 36 patients having seroconversion i.e AntiHBeantibody positive, while it was also normal in 5 HBeAg positive patients. Common risk factors detected in these patients were intramuscular injections, surgery and dental treatment, however, in a large number, risk factors were unknown. Conclusion: Fifteen percent asymptomatic subjects with positive HBsAg were found to be HBeAg positive. Large number of patients 79% has seroconversiqn and only 11.6 % have HBV DNA detected in their serum. Intramuscular injections surgery and dental treatment were noted to be frequent risk factors in these subjects. (author)

  20. Differing results of direct and indirect solid phase radioimmunoassay for HBsAg in acute hepatitis

    In 54 patients suffering from active viral hepatitis the indirect solid phase radioimmunoassay (ind-SPRIA) for HBsAg was positive in 9 cases the direct solid phase radioimmunoassay (d-SPRIA) being negative. In 2 further cases ind-SPRIA was positive during several weeks but d-SPRIA only once. AntiHBc could be detected in 9 of these patients. In 7 patients the usual decrease of the transaminase activity was followed by a second elavation with prolongation of the disease. The unknown factor detected by ind-SPRIA suggests a special of acute hepatitis. (orig.)

  1. Transgenic lettuce seedlings carrying hepatitis B virus antigen HBsAg

    Jackson Marcondes

    2008-12-01

    Full Text Available The obtainment of transgenic edible plants carrying recombinant antigens is a desired issue in search for economic alternatives viewing vaccine production. Here we report a strategy for genetic transformation of lettuce plants (Lactuca sativa L. using the surface antigen HBsAg of hepatitis B virus. Transgenic lettuce seedlings were obtained through the application of a regulated balance of plant growth regulators. Genetic transformation process was acquired by cocultivation of cotyledons with Agrobacterium tumefaciens harboring the recombinant plasmid. It is the first description of a lettuce Brazilian variety "Vitória de Verão" genetically modified.

  2. Reactivation of viral replication in anti-HBe positive chronic HBsAg carriers

    Krogsgaard, K; Aldershvile, J; Kryger, Peter;

    1990-01-01

    Reactivation of hepatitis B virus replication was investigated in an unselected group of 44 HBV DNA negative, anti-HBe positive chronic HBsAg carriers. Twenty-five patients (54%) were intravenous drug addicts and 7 (16%) were male homosexuals. Sixteen patients had evidence of delta infection and...... five of the seven male homosexuals had human immunodeficiency virus infection. The patients were followed for 1 to 180 months (median, 24 months) while HBV DNA negative, anti-HBe positive. Reactivation, defined as reappearance of HBV DNA or HBeAg, or both, was detected in six patients corresponding to...

  3. Self-referenced prism deflection measurement schemes with microradian precision

    Olson, R; Bergeson, S; Durfee, D S; Olson, Rebecca; Paul, Justin; Bergeson, Scott; Durfee, Dallin S.

    2005-01-01

    We have demonstrated several inexpensive methods which can be used to measure the deflection angles of prisms with microradian precision. The methods are self-referenced, using various reversals to achieve absolute measurements without the need of a reference prism or any expensive precision components other than the prisms under test. These techniques are based on laser interferometry and have been used in our lab to characterize parallel-plate beamsplitters, penta prisms, right angle prisms, and corner cube reflectors using only components typically available in an optics lab.

  4. Viral hepatitis and rapid diagnostic test based screening for HBsAg in HIV-infected patients in rural Tanzania.

    Fabian C Franzeck

    Full Text Available BACKGROUND: Co-infection with hepatitis B virus (HBV is highly prevalent in people living with HIV in Sub-Saharan Africa. Screening for HBV surface antigen (HBsAg before initiation of combination antiretroviral therapy (cART is recommended. However, it is not part of diagnostic routines in HIV programs in many resource-limited countries although patients could benefit from optimized antiretroviral therapy covering both infections. Screening could be facilitated by rapid diagnostic tests for HBsAg. Operating experience with these point of care devices in HIV-positive patients in Sub-Saharan Africa is largely lacking. We determined the prevalence of HBV and Hepatitis C virus (HCV infection as well as the diagnostic accuracy of the rapid test device Determine HBsAg in an HIV cohort in rural Tanzania. METHODS: Prospectively collected blood samples from adult, HIV-1 positive and antiretroviral treatment-naïve patients in the Kilombero and Ulanga antiretroviral cohort (KIULARCO in rural Tanzania were analyzed at the point of care with Determine HBsAg, a reference HBsAg EIA and an anti-HCV EIA. RESULTS: Samples of 272 patients were included. Median age was 38 years (interquartile range [IQR] 32-47, 169/272 (63% subjects were females and median CD4+ count was 250 cells/µL (IQR 97-439. HBsAg was detected in 25/272 (9.2%, 95% confidence interval [CI] 6.2-13.0% subjects. Of these, 7/25 (28% were positive for HBeAg. Sensitivity of Determine HBsAg was rated at 96% (95% CI 82.8-99.6% and specificity at 100% (95% CI, 98.9-100%. Antibodies to HCV (anti-HCV were found in 10/272 (3.7%, 95% CI 2.0-6.4% of patients. CONCLUSION: This study reports a high prevalence of HBV in HIV-positive patients in a rural Tanzanian setting. The rapid diagnostic test Determine HBsAg is an accurate assay for screening for HBsAg in HIV-1 infected patients at the point of care and may further help to guide cART in Sub-Saharan Africa.

  5. Abbott AXSYM免疫分析仪几种节约试剂方法

    徐忠玉; 梁声强; 邓小军

    2006-01-01

    Abbott AXSYM免疫分析仪是目前比较理想的全自动免疫分析仪器,但该仪器所用的试剂昂贵也是实际。因此如何在不影响检测结果的基础上,节约成本、减少浪费是值得关注的问题。我们在使用过程中,摸索和总结了几种节约试剂用量和利用剩余试剂的方法,现介绍如下,供参考。

  6. 美国Abbott Axsym免疫分析仪性能初步评价

    成军; 袁兴旺; 金晶; 王国政; 孙长贵; 孙关忠

    2003-01-01

    @@ 随着国内临床免疫学实验室自动化程度的不断提高,全自动免疫分析仪逐步得到普及和应用[1],本文以检测乙型肝炎病毒表面抗原(HBsAg)为例,对美国Abbott Axsym免疫分析仪微粒子酶免疫分析(MEIA)技术的灵敏度、可检测性、特异性、重复性、线性、干扰试验及与酶联免疫吸附试验(ELISA)检测HBsAg的相关性等指标进行了检测,以评价其性能.

  7. 巧用AbbottC8000的Retest功能进行试剂比对

    刘风华

    2013-01-01

    目的通过AbbottC8000本身具有的“RetestRule”功能进行试剂间的比对,观察同一仪器同一项目不同试剂间的检测结果是否具有可比性。方法在Abbott(;8000上调试同一项目两种试剂(bun)参数,并设定“RetestRule”。结果通过对比对数据的统计学分析,得到两系统间相关性良好,R2=0.9991。结论运用Ab—bottC8000的“RetestRule”功能可以简便、快捷的完成比对实验,值得推广。

  8. Performance of the new automated Abbott RealTime MTB assay for rapid detection of Mycobacterium tuberculosis complex in respiratory specimens.

    Chen, J H K; She, K K K; Kwong, T-C; Wong, O-Y; Siu, G K H; Leung, C-C; Chang, K-C; Tam, C-M; Ho, P-L; Cheng, V C C; Yuen, K-Y; Yam, W-C

    2015-09-01

    The automated high-throughput Abbott RealTime MTB real-time PCR assay has been recently launched for Mycobacterium tuberculosis complex (MTBC) clinical diagnosis. This study would like to evaluate its performance. We first compared its diagnostic performance with the Roche Cobas TaqMan MTB assay on 214 clinical respiratory specimens. Prospective analysis of a total 520 specimens was then performed to further evaluate the Abbott assay. The Abbott assay showed a lower limit of detection at 22.5 AFB/ml, which was more sensitive than the Cobas assay (167.5 AFB/ml). The two assays demonstrated a significant difference in diagnostic performance (McNemar's test; P = 0.0034), in which the Abbott assay presented significantly higher area under curve (AUC) than the Cobas assay (1.000 vs 0.880; P = 0.0002). The Abbott assay demonstrated extremely low PCR inhibition on clinical respiratory specimens. The automated Abbott assay required only very short manual handling time (0.5 h), which could help to improve the laboratory management. In the prospective analysis, the overall estimates for sensitivity and specificity of the Abbott assay were both 100 % among smear-positive specimens, whereas the smear-negative specimens were 96.7 and 96.1 %, respectively. No cross-reactivity with non-tuberculosis mycobacterial species was observed. The superiority in sensitivity of the Abbott assay for detecting MTBC in smear-negative specimens could further minimize the risk in MTBC false-negative detection. The new Abbott RealTime MTB assay has good diagnostic performance which can be a useful diagnostic tool for rapid MTBC detection in clinical laboratories. PMID:26071001

  9. Deborah Abbott: Out in the Redwoods, Documenting Gay, Lesbian, Bisexual, Transgender History at the University of California, SAnta Cruz, 1965-2003

    Reti, Irene H.; Brashear, Regan; Abbott, Deborah

    2004-01-01

    Deborah Abbott is a writer, health activist, teacher, river guide and current director of the Gay, Lesbian, Bisexual and Transgender Resource Center at UCSC. Since assuming her position in November of 1997, she has given new shape and direction to the Center. As an American studies major, I was eager to interview  Deb Abbott. Deb Abbott to learn more about the queer history of UCSC, as well as about her work within two local feminist health organizations: the Santa Cruz Women's Health Collect...

  10. Multivariable control for the PRISM ALMR

    This paper describes the application of state variable control design methods in the conceptual design of two key system level controllers in the PRISM ALMR. The PRISM plant concept consists of three power blocks, each made up of three identical reactors and steam generator modules connected to one turbine. Operation of these physically distributed systems is directed by a hierarchy of controllers at the system, power block, and plant levels. The system level controllers in this paper are the reactivity controllers for movement of the six control rods in each of the nine reactor modules, and the feedwater control of the three parallel steam generators in each of the three power blocks. 4 refs., 6 figs., 1 tab

  11. Evaluations of 1990 PRISM design revisions

    Analyses of the 1990 version of the PRISM Advanced Liquid Metal Reactor (ALMR) design are presented and discussed. Most of the calculations were performed using BNL computer codes, particularly SSC and MINET. In many cases, independent BNL calculations were compared against analyses presented by General Electric when they submitted the PRISM design revisions for evaluation by the Nuclear Regulatory Commission (NRC). The current PRISM design utilizes the metallic fuel developed by Argonne National Laboratory (ANL) which facilitates the passive/''inherent'' shutdown mechanism that acts to shut down reactor power production whenever the system overheats. There are a few vulnerabilities in the passive shutdown, with the most worrisome being the positive feedback from sodium density decreases or sodium voiding. Various postulated unscrammed events were examined by GE and/or BNL, and much of the analysis discussed in this report is focused on this category of events. For the most part, the BNL evaluations confirm the information submitted by General Electric. The principal areas of concern are related to the performance of the ternary metal fuel, and may be resolved as ANL continues with its fuel development and testing program

  12. Risley prism universal pointing system (RPUPS)

    Dixon, John; Engel, James R.; Vaillancourt, Robert; Schwarze, Craig; Potter, Kevin

    2015-09-01

    OPTRA is currently developing a Risley Prism Universal Pointing System (RPUPS): a highly customizable cued beamsteering system. The RPUPS consists of a visible or infrared cueing imager co-aligned with an optical beam steering system's pointing-field-of-regard. The cueing imager is used to identify a region-of-interest within its wide field-of-view, via a wireless tablet device. The tablet user can choose to manually or automatically, identify and track regions-of-interest. The optical beam steering system uses a matched pair of Risley Prisms to direct an interrogating optical system's instantaneous-field-of-view onto the identified region-of-interest. The tablet updates the user with real time information from both the cueing imager and the interrogating optical system. Risley prism material and geometry choices provide operating wavelength, aperture size, and field-of-regard flexibility for this front-end pointing component. Back-end components may be receive-only, transmit-only, or transmit/receive combinations. The flexibility of the RPUPS allows for mission specific customization where applications include but are not limited to: synthetic foveated imaging, spectroscopic probes and laser (LIDAR) ranging and tracking. This paper will focus on the design and anticipated applications of the RPUPS.

  13. Evaluations of 1990 PRISM design revisions

    Van Tuyle, G.J.; Slovik, G.C.; Chan, B.C.; Aronson, A.L.; Kennett, R.J. [Brookhaven National Lab., Upton, NY (United States)

    1992-03-01

    Analyses of the 1990 version of the PRISM Advanced Liquid Metal Reactor (ALMR) design are presented and discussed. Most of the calculations were performed using BNL computer codes, particularly SSC and MINET. In many cases, independent BNL calculations were compared against analyses presented by General Electric when they submitted the PRISM design revisions for evaluation by the Nuclear Regulatory Commission (NRC). The current PRISM design utilizes the metallic fuel developed by Argonne National Laboratory (ANL) which facilitates the passive/``inherent`` shutdown mechanism that acts to shut down reactor power production whenever the system overheats. There are a few vulnerabilities in the passive shutdown, with the most worrisome being the positive feedback from sodium density decreases or sodium voiding. Various postulated unscrammed events were examined by GE and/or BNL, and much of the analysis discussed in this report is focused on this category of events. For the most part, the BNL evaluations confirm the information submitted by General Electric. The principal areas of concern are related to the performance of the ternary metal fuel, and may be resolved as ANL continues with its fuel development and testing program.

  14. An investigation on ABO and Rh blood groups and HBsAg, anti-HIV, VDRL positivity

    GENÇ, Dr. Metin; ASLAN, Dr. Turan

    1997-01-01

    Using records, we screened 2500 blood donors for blood groups, hepatitis-B surface antigen (HBsAg), anti-HIV, and VDRL. The results were analysed to assess the prevalence and the possible relation to sex and blood groups. Our present study was done at Regional Blood Center in Malatya province. The distribution of blood groups was compared with other studies. Our findings suggested that the prevalence of HBsAg was 5.16% in the donor population. VDRL and anti-HIV positivity were not found. HBsA...

  15. A Delayed Type Hypersensitivity (DTH) Skin Reaction to Hepatitis B Surface Antigen (HBsAg) and Intradermal Hepatitis B Vaccination

    Nagafuchi, Seiho; Kashiwagi, Seizaburo; Hayashi, Jun; Katsuta, Hitoshi; Ikematsu, Hideyuki; Harada, Mine

    2004-01-01

    The significance of a delayed type hypersensitivity skin reaction to hepatitis B surface antigen (HBsAg) (HBs-DTH) in type B viral hepatitis (VHB) and in intradermal hepatitis B (HB) vaccination is reviewed. HBs-DTH could be developed by the intradermal injection of HB vaccine in anti-HBs positive people and also in persons immunized with HB vaccine. Thus, HBs-DTH could serve as a useful marker for the acquisition of an active Thl type immunoreactivity to HBsAg. HBs-DTH was absent in patients...

  16. Frequency of anti-HCV, Hbsag and related risk factors in pregnant women at Nishtar Hospital, Multan

    Background: Viral hepatitis is a global issue. Among the hepatitis viruses hepatitis B and C are important in South Asia including Pakistan. There are various modes of transmission of these viruses. Vertical transmission is also gaining importance. Antepartum screening for HBV and HCV would help the infected women for appropriate antiviral therapy at appropriate time as well as for taking proper care of the newborns. The present study was designed to see the frequency of HBsAg and anti-HCV in pregnant women at Nishtar Hospital, Multan. Methods: This was a cross-sectional study carried out using non-probability purposive sampling technique. The period of the study was from June 2006 to August 2007. Five hundred (500) pregnant women attending outpatient department of Gynaecology and Obstetrics were included. Informed consent was taken. A specially designed proforma was filled in. Anti-HCV and HBsAg were tested by device method. Data were analyzed on SPSS-11. Results: Out of 500 pregnant women 35 (7.00%) were found to be anti-HCV positive and 23 (4.60%) were positive for HBsAg. Mean age was 26.7+-4.8 years. Majority of the patients 263 (52.60%) were in the age group 26-35 years. 138 (27.60%) women were nulliparous and 282 (56.40%) were para 1-4 and anti-HCV and HBsAg were common in this parity group. Only 80 (16.00%) women were para 5 or more. All anti-HCV and HBsAg positive women were house-wives. Most of them were belonging to rural areas having poor socio-economic status. Among 35 anti-HCV positive women, 20 (57.14%) had history of previous surgery, while 13 (37.14%) had history of multiple injections, 5 (14.28%) received blood transfusion, 4 (11.42%) had ear/nose piercing while tattooing was seen in only 2 (5.71%). Among 23 HBsAg positive women, 10 (43.47%) had history of previous surgery. History of multiple injections was present in 6 (26.08%) patients, 4 (17.39%) patients had history of blood transfusion, tattooing, ear/nose piercing, history of dental

  17. Detection of HBsAg and Anti HBc on donors of a blood bank by IRMA and ELISA methods

    Comparative evaluation of two methods, Immunoradiometric Assay (IRMA) and Enzyme Immunoassay (ELISA), for detecting HBsAg and Anti HBc was made for determining which is the most advantageous and reliable. The study was made on 300 donors of the Hospital San Juan de Dios Blood Bank. In comparison with the reference method (IRMA), ELISA shows 91.67% of sensitivity. The Anti HBc detection by IRMA is more reliable than the HBsAg detection by IRMA and ELISA for determining the carrier state

  18. Impact of the New Abbott mPLUS Feature on Clinical Laboratory Efficiencies of Abbott RealTime Assays for Detection of HIV-1, Hepatitis C Virus, Hepatitis B Virus, Chlamydia trachomatis, and Neisseria gonorrhoeae

    Lucic, Danijela; Jones, Sara; Wiesneth, Russ; Barry, Cathy; Webb, Erika; Belova, Larissa; Dolan, Peggy; Ho, Shiaolan; Abravaya, Klara; Cloherty, Gavin

    2013-01-01

    Diagnostic laboratories are under increasing pressure to improve and expand their services. Greater flexibility in sample processing is a critical factor that can improve the time to results while reducing reagent waste, making laboratories more efficient and cost-effective. The introduction of the Abbott mPLUS feature, with the capacity for extended use of amplification reagents, significantly increases the flexibility of the m2000 platform and enables laboratories to customize their workflo...

  19. PRogram In Support of Moms (PRISM): Development and Beta Testing.

    Byatt, Nancy; Pbert, Lori; Hosein, Safiyah; Swartz, Holly A; Weinreb, Linda; Allison, Jeroan; Ziedonis, Douglas

    2016-08-01

    Most women with perinatal depression do not receive depression treatment. The authors describe the development and beta testing of a new program, PRogram In Support of Moms (PRISM), to improve treatment of perinatal depression in obstetric practices. A multidisciplinary work group of seven perinatal and behavioral health professionals was convened to design, refine, and beta-test PRISM in an obstetric practice. Iterative feedback and problem solving facilitated development of PRISM components, which include provider training and a toolkit, screening procedures, implementation assistance, and access to immediate psychiatric consultation. Beta testing with 50 patients over two months demonstrated feasibility and suggested that PRISM may improve provider screening rates and self-efficacy to address depression. On the basis of lessons learned, PRISM will be enhanced to integrate proactive patient engagement and monitoring into obstetric practices. PRISM may help overcome patient-, provider-, and system-level barriers to managing perinatal depression in obstetric settings. PMID:27079994

  20. Collaborative evaluation of the Abbott Avantage system for identification of frequently isolated nonfermentative or oxidase-positive gram-negative bacilli.

    Jorgensen, J H; Dyke, J W; Helgeson, N G; Cooper, B. H.; Redding, J S; Crawford, S. A.; Andruszewski, M T; Prowant, S A

    1984-01-01

    The capability of the Abbott Avantage system to identify 10 species of commonly isolated glucose nonfermentative or oxidase-positive gram-negative bacilli in a 5-h test period was evaluated in a collaborative study. The Avantage nonenteric data base uses 20 biochemical test reactions performed in an expanded Abbott bacterial identification cartridge plus the results of a manual oxidase test. The species included in the Avantage data base are Acinetobacter anitratus, Acinetobacter Iwoffi, Aero...

  1. Reactivation of viral replication in anti-HBe positive chronic HBsAg carriers

    Krogsgaard, K; Aldershvile, J; Kryger, Peter;

    1990-01-01

    Reactivation of hepatitis B virus replication was investigated in an unselected group of 44 HBV DNA negative, anti-HBe positive chronic HBsAg carriers. Twenty-five patients (54%) were intravenous drug addicts and 7 (16%) were male homosexuals. Sixteen patients had evidence of delta infection and...... five of the seven male homosexuals had human immunodeficiency virus infection. The patients were followed for 1 to 180 months (median, 24 months) while HBV DNA negative, anti-HBe positive. Reactivation, defined as reappearance of HBV DNA or HBeAg, or both, was detected in six patients corresponding to...... an annual reactivation rate of 5%. Reactivation in four patients was detected by reversion to HBV DNA positivity only, whereas HBeAg/anti-HBe status remained unchanged. Two patients became both HBV DNA and HBeAg positive. None of the patients developed hepatitis-like symptoms and transaminase...

  2. Minimal residual HIV viremia: verification of the Abbott Real-Time HIV-1 assay sensitivity

    Alessandra Amendola

    2010-06-01

    Full Text Available Introduction: In the HIV-1 infection, the increase in number of CD4 T lymphocytes and the viral load decline are the main indicators of the effectiveness of antiretroviral therapy. On average, 85% of patients receiving effective treatment has a persistent suppression of plasma viral load below the detection limit (<50 copies/mL of clinically used viral load assays, regardless of treatment regimen in use. It is known, however, that, even when viremia is reduced below the sensitivity limit of current diagnostic assays, the virus persists in “reservoirs” and traces of free virions can be detected in plasma.There is a considerable interest to investigate the clinical significance of residual viremia. Advances in molecular diagnostics allows nowadays to couple a wide dynamic range to a high sensitivity.The Abbott Real-time HIV-1 test is linear from 40 to 107 copies/mL and provides, below 40 copies/mL, additional information such as “<40cp/mL, target detected” or “target not detected”. The HIV-1 detection is verified by the max-Ratio algorithm software.We assessed the test sensitivity when the qualitative response is considered as well. Methods: A ‘probit’ analysis was performed using dilutions of the HIV-1 RNA Working Reagent 1 for NAT assays (NIBSC code: 99/634, defined in IU/mL and different from that used by the manufacturer (VQA,Virology Quality Assurance Laboratory of the AIDS Clinical Trial Group for standardization and definition of performances.The sample input volume (0.6 mL was the same used in clinical routine. A total of 196 replicates at concentrations decreasing from 120 to 5 copies/mL, in three different sessions, have been tested.The ‘probit’ analysis (binomial dose-response model, 95% “hit-rate” has been carried out on the SAS 9.1.3 software package. Results: The sensitivity of the “<40cp/mL, target detected” response was equal to 28,76 copies/mL, with 95% confidence limits between 22,19 and 52,27 copies

  3. Efficacy evaluation of two synthetic lysine lipidated tripeptides as vaccine adjuvants against HBsAg.

    Sidiq, Tabasum; Khajuria, Anamika; Shafi, Syed; Ismail, Tabasum; Sampath Kumar, Halmathur; Kannappa Srinivas, Vellimedu; Krishna, Ella; Kamal Johri, Rakesh

    2013-04-01

    In the present investigation, adjuvant potential of two novel lipidated tripeptide lysine derivatives (KKSM and KKSMB) was evaluated using various in vitro and animal-derived models of humoral and cell-mediated immune events in response to hepatitis B surface antigen (HBsAg). The results were compared with alum adjuvanted with HBsAg. Both these molecules were found to stimulate anti-HBsAg IgG and neutralizing (IgG1 and IgG2a) antibody titres in mice sera. The two molecules stimulated the proliferation of T-lymphocyte sub-sets (CD4/CD8) as well as the production of soluble mediators of Th1 (IL-2 and IFN-γ) and Th2 response (IL-4) in spleen cell culture supernatant. Furthermore, the two lipidated tripeptides enhanced the CD4, CD8, CD3 and CD19 cell populations as well as CD4/CD8 derived IL-2, IL-4, IFN-γ and TNF-α in whole blood of treated mice. There was found to be the significant enhancement in the release of IL-12, IFN-γ and nitrite content in macrophage supernatant. Moreover, the two lipidated tripeptides enhanced the population of CD80 and CD86 in spleen-derived macrophages and did not show any hemolytic effect on rabbit RBCs. Taken together, these results suggest that both these molecules are the potent enhancers of anti-HBsAg immune response via augmenting Th1/Th2 response in a dose dependent manner. PMID:23474022

  4. Performance of the Abbott RealTime CT/NG for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae▿

    Gaydos, C A; Cartwright, C P; Colaninno, P.; Welsch, J.; Holden, J; Ho, S. Y.; Webb, E. M.; Anderson, C.; Bertuzis, R.; Zhang, L.; Miller, T; Leckie, G.; Abravaya, K.; Robinson, J.

    2010-01-01

    A multicenter clinical study was conducted to evaluate the performance characteristics of the Abbott RealTime CT/NG assay, a multiplex real-time PCR assay, for simultaneous detection of Chlamydia trachomatis and Neisseria gonorrhoeae. The specimens were collected from a total of 3,832 male and female subjects at 16 geographically diverse sites. Specimens included male and female urine samples, male urethral swabs, female endocervical swabs, and self-collected and clinician-collected vaginal s...

  5. Evaluation of the Abbott LCx Mycobacterium tuberculosis Assay for Direct Detection of Mycobacterium tuberculosis Complex in Human Samples

    Garrino, M. G.; Glupczynski, Gerald; Degraux, J; Nizet, H; Delmée, Michel

    1999-01-01

    Seven hundred thirty-seven clinical samples from 460 patients were processed for direct detection of Mycobacterium tuberculosis complex by a semiautomated ligase chain reaction commercial assay, the LCx Mycobacterium tuberculosis Assay (LCx assay) from Abbott Laboratories. Results were compared to those of direct microscopy and standard microbiological culture. Of 26 patients (5.7%) with a culture positive for M. tuberculosis, 22 (84.6%) were found positive by the LCx assay. The sensitivity o...

  6. Evaluation of an Automated Liquid-Handling System (Tecan Genesis RSP 100) in the Abbott LCx Assay for Chlamydia trachomatis

    Hanson, Kevan L.; Cartwright, Charles P.

    2001-01-01

    The present study investigated the feasibility of automating the specimen-pipetting component of sample preparation in the LCx Chlamydia assay (LCx-CT assay; Abbott Laboratories, Chicago, Ill.) by using a commercially available liquid-handling system (Tecan Genesis RSP100; Tecan Inc., Research Triangle Park, N.C.). The Tecan instrument proved to be comparable in both precision and accuracy to a manual multipipettor (Eppendorf model 4850; Eppendorf Scientific, Westbury, N.Y.). The Tecan instru...

  7. Posintro™-HBsAg, a modified ISCOM including HBsAg, induces strong cellular and humoral responses

    Schiött, Asa; Larsson, Kristina; Manniche, Søren;

    2011-01-01

    HBsAg vaccine formulation, Posintro™-HBsAg, was compared to two commercial hepatitis B vaccines including aluminium or monophosphoryl lipid A (MPL) and the two adjuvant systems MF59 and QS21 in their efficiency to prime both cellular and humoral immune responses. The Posintro™-HBsAg induced...

  8. Pure rotation of a prism on a ramp

    Zhao, Zhen; Liu, Caishan; Ma, Daolin

    2014-01-01

    In this work, we study a prism with a cross section in polygon rolling on a ramp inclined at a small angle. The prism under gravity rolls purely around each individual edge, intermittently interrupted by a sequence of face collisions between the side face of the prism and the ramp. By limiting the prism in a planar motion, we propose a mathematical model to deal with the events of the impacts. With a pair of laser-Doppler vibrometers, experiments are also conducted to measure the motions of v...

  9. Wollaston prism phase-stepping point diffraction interferometer and method

    Rushford, Michael C.

    2004-10-12

    A Wollaston prism phase-stepping point diffraction interferometer for testing a test optic. The Wollaston prism shears light into reference and signal beams, and provides phase stepping at increased accuracy by translating the Wollaston prism in a lateral direction with respect to the optical path. The reference beam produced by the Wollaston prism is directed through a pinhole of a diaphragm to produce a perfect spherical reference wave. The spherical reference wave is recombined with the signal beam to produce an interference fringe pattern of greater accuracy.

  10. Detection of hepatitis B virus infection in HBsAg-negative patients by monoclonal antibodies against HBsAg

    The technique of producing antibody secreting hybridomas has made available high-affinity antibodies of predefined specificity for use as diagnostic reagents. Recently, high-affinity monoclonal antibodies to hepatitis B surface antigens (HBsAg) were produced and characterized. Immunoassay was developed using these antibodies for the detection of HBsAg-associated determinants. The present study indicated the significance of the enhanced detection by monoclonal radioimmunoassay (M-RIA) of HBsAg in sera of patients with hepatitis B virus infection. The M-RIA detected HBsAg in sera of hemodialysis patients and blood donor defined as HBsAg-negative by polyclonal RIA (2.2 %, 0.14 %, respectively). Furthermore, individuals with chronic liver diseases were reactive only in the M-RIA (chronic hepatitis 4.8 %, liver cirrhosis 10.0 %, hepatocellular carcinoma 22.2 %). It is noteworthy that some of these patients were diagnosesed as so-called non-A non-B hepatitis because of no serological markers of hepatitis B virus infection such as HBsAb and HBcAb. The enhanced performance of the monoclonal RIA compared to conventional RIA was due to the increased sensitivity of the assay (55 pg vs 230 pg/ml). In immunohistochemical study, one of the monoclonal antibody named 5C3 was applied for detection of HBsAg in the formalin-fixed paraffin-embedded liver. HBsAg was detected in 6 out of 41 HBsAg-seronegative liver specimen. Thus, the studies showed the importance of the clinical application of monoclonal antibodies such as immunoassay and immunohistochemical study in the diagnosis of hepatitis B virus infection. (author)

  11. Inherent safety and design certification of PRISM

    General Electric Company has introduced an innovative technological approach to reactor design that, when combined with change in US Nuclear Regulatory Commission (NRC) practice, will lead to safe and economically competitive fast breeder reactor electric power plants. The key elements in this approach are characteristics in the reactor that will cause it to passively control reactivity and shutdown and passively cool itself without action by the human operators or active devices that require energy supplies external to the reactor module. These characteristics have been called the inherent features or the inherency of the design. They are inherent because they depend on only the material and geometric properties of the reactor module design. Thermal expansion and deflections as well as temperature dependent nuclear properties, such as the Doppler effect, are examples of inherent behavior. Natural convection due to density differences in fluid coolant paths is another example. These characteristics do not depend on active devices that require external energy supplies. PRISM uses natural circulation cooling for safety grade decay heat removal. Negative reactivity feedback with increasing temperature will balance the power generated with the heat removed. The PRISM also incorporates a factory fabricated containment barrier that encloses the reactor and primary coolant. The reactor module design is being developed so that the inherent characteristics of the reactor module can be tested in a full scale prototype. Results from this testing along with other safety and design information will be used to obtain NRC Design Certification

  12. Identifying Codes in the Complementary Prism of Cycles

    Cappelle, Marcia R.; Coelho, Erika M. M.; Coelho, Hebert; Penso, Lucia D.; Rautenbach, Dieter

    2015-01-01

    We show that an identifying code of minimum order in the complementary prism of a cycle of order $n$ has order $7n/9+\\Theta(1)$. Furthermore, we observe that the clique-width of the complementary prism of a graph of clique-width $k$ is at most $4k$, and discuss some algorithmic consequences.

  13. A Study of the PDGF Signaling Pathway with PRISM

    Qixia Yuan; Jun Pang; Sjouke Mauw; Panuwat Trairatphisan; Monique Wiesinger; Thomas Sauter

    2011-01-01

    In this paper, we apply the probabilistic model checker PRISM to the analysis of a biological system -- the Platelet-Derived Growth Factor (PDGF) signaling pathway, demonstrating in detail how this pathway can be analyzed in PRISM. We show that quantitative verification can yield a better understanding of the PDGF signaling pathway.

  14. New Light on a Prism: The Concert for All Reasons

    Linaberry, Robin

    2004-01-01

    The prism concert concept was introduced in this country at the Eastman School of Music in 1975. The development of Eastman's inaugural prism concert is commonly attributed to Donald Hunsberger and Gustav Meier, conductors of the wind ensemble and orchestra, respectively. The basic idea is that different styles of music performed by different…

  15. The Variprism: A Large-Range Variable Prism for Measurement of the Angle of Squint

    Simonsz, Huib

    1988-01-01

    textabstractPrism bars and variable Herschel prisms are most commonly used today to measure the angle of squint. Both have drawbacks, however. Prism bars are too large to carry around all day and are usually limited to 40 prism diopters (PD), while variable Herschel prisms have even smaller ranges. Hans Meester and I have therefore developed, at the Netherlands Ophthalmic Research Institute, Amsterdam, a hand-held prism that is continuously variable over a large range, horizontally as well as...

  16. Efficacy of enteroclysis through Miller-Abbott tube for decompression in patients with postoperative intestinal obstruction

    The purpose of this study is to assess the efficacy of enteroclysis through the previously inserted Miller-Abbott (M-A) tube for decompression in the postoperative intestinal obstruction. This study includes twenty patients who has intestinal obstruction symptoms after operation for benign(12) or malignant(8) abdominal lesions. Small amount of barium was introduced to M-A tube for enteroclysis. We evaluated the presence, level, degree, and causes of obstruction on enteroclysis, compared with surgical(11) and clinical(9) findings. Obstruction was seen in 18 cases including the two cases in which the level of obstruction was not clear. There was no obstruction in two cases. Obstruction on enteroclysis was demonstrated in all 11 operated cases(100% accuracy, 11/11). The level of obstruction on enteroclysis were jejunum in three cases, ileum in seven, and colon in one case. The levels of obstruction on enteroclysis were matched with those in operation field in 10 cases. There were two cases of nonobstruction on enteroclysis were jejunum in three cases, ileum in seven, and colon in one case. The levels of obstruction on enteroclysis were matched with those in operation field in 10 cases. There were two cases of nonobstruction, nine cases of low-grade partial obstruction, and nine cases of high-grade partial obstruction. We analyzed the findings on enteroclysis regarding causes of obstruction in 16 patients with the findings of adhesive bands of extrinsic cause(9), cancer recurrence of intrinsic cause(6), and bezoar of intraluminal cause(1). Misinterpreted cases were two cases(87.7% accuracy, 14/16). The cause, for nonvisualization of obstruction site on enteroclysis in four patients included technical failure such as inadequate location of tube(1) and bowel overlapping(1), minimal obstruction(1), and nonexistent obstruction(1), in spite of diffuse edematous mucosa. Enteroclysis through the M-A tube for decompression in patients with postoperative intestinal obstruction

  17. Active stereo vision routines using PRISM-3

    Antonisse, Hendrick J.

    1992-11-01

    This paper describes work in progress on a set of visual routines and supporting capabilities implemented on the PRISM-3 real-time vision system. The routines are used in an outdoor robot retrieval task. The task requires the robot to locate a donor agent -- a Hero2000 -- which holds the object to be retrieved, to navigate to the donor, to accept the object from the donor, and return to its original location. The routines described here will form an integral part of the navigation and wide-area search tasks. Active perception is exploited to locate the donor using real-time stereo ranging directed by a pan/tilt/verge mechanism. A framework for orchestrating visual search has been implemented and is briefly described.

  18. ASSOCIATION OF HBsAG WITH SEVERE MALARIA - FACT OR FICTION?

    Anup K

    2012-12-01

    Full Text Available ABSTRACT: India lies in the endemic belt of PF malaria. Annua lly we are faced with regular outbreaks of severe malaria with its attendent adve rse effects on public health in the North-East also. Owing to the diverse geographic, sociopolitical , economic, ethnic and cultural characteristics, this region is also ideal for futu re “epidemics” of potentially dangerous consequences of HBV infection e.g in Arunachal Prad esh in particular. Epidemiologically, a significant serological association between HbsAg po sitivity and severe malaria has been reported recently from Africa(,Gambia. But, the mul tiple factors predisposing to severe malaria, and those influencing the progression of HB V infection have not been elucidated properly. It was postulated that the liver stage parasi tes are not properly cleared due to concurrent HBV infection of the hepatocytes. Inducib le Genetic mutations protective in nature may be a factor. Similarly, those who are vaccinate d against HBV are reported to suffer from malaria in South Asia. However, it is premature to d raw any definite conclusions as our personal experience give us results to the contrary.

  19. Evaluation of HBsAg, anti-HCV, anti-HIV and VDRL test results in blood donors

    Deveci, Özcan; Tekin, Alicem; Günbay, Seda Sibel; Kılıç, Dilek; KAYGUSUZ, Sedat; Ağalar, Canan; Özer, Türkan Toka

    2011-01-01

    Objectives: The most frequently encountered complication in the transfusion of blood and blood products are transmitted infections from these products. Infections caused by hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) remain the leading most important health problems in the transfusion of blood and blood products worldwide. Therefore, screening tests such as HBsAg, anti-HCV, anti-HIV, and RPR or VDRL for Treponema pallidum are mandatory tests to loo...

  20. Intra-familial prevalence of hepatitis B virologic markers in HBsAg positive family members in Nahavand, Iran

    Amir Houshang Mohammad Alizadeh; Mitra Ranjbar; Shahin Ansari; Seyed Moayed Alavian; Hamid Mohaghegh Shalmani; Leila Hekmat; Mohammad Reza Zali

    2005-01-01

    AIM: To determine the prevalence of hepatitis B in Nahavand and evaluate the HBsAg positive prevalence in families with a member who was confirmed to have HBV infection.METHODS: This study was performed in two phases. In the first phase, 1 824 subjects in Nahavand city were selected. The interviewers visited the houses of chosen families to fill the questionnaire and take the blood samples.All subjects signed an informed consent before interviews and blood sampling. The samples were evaluated for HBV virologic markers. In the second phase, 115 HBsAg-positive cases were enrolled and evaluated for HBV virologic markers.RESULTS: The prevalence of positive HBsAg in Nahavand was 2.3%. The most frequent relatives of index cases were sons and daughters (32.2% and 23.5% respectively).Twelve (11%) of all family members were HBsAg positive.Fifty (56.2%) were isolated HBsAb positive and only one person (2.5%) was isolated HBcAb positive. The higher rates of HBsAg marker were detected in the brothers (1-25%) and fathers (1-12.5%). The infection rate in husbands and wives of index cases was 10%. Only two (16.7%) of all HBsAg-positive participants reported previous HBV vaccination.CONCLUSION: The prevalence of intra-familial HBV infection is lower in Nahavand of Iran compared to other studies.More attention should be paid to HBV vaccination and risk-lowering activities.

  1. Spatial compression impairs prism-adaptation in healthy individuals

    Roger Newport

    2013-05-01

    Full Text Available Neglect patients typically present with gross inattention to one side of space following damage to the contralateral hemisphere. While prism-adaptation is effective in ameliorating some neglect behaviours, the mechanisms involved and their relationship to neglect remain unclear. Recent studies have shown that conscious strategic control processes in prism-adaptation may be impaired in neglect patients, who are also reported to show extraordinarily long aftereffects compared to healthy participants. Determining the underlying cause of these effects may be the key to understanding therapeutic benefits. Alternative accounts suggest that reduced strategic control might result from a failure to detect prism-induced reaching errors properly either because a the size of the error is underestimated in compressed visual space or b pathologically increased error detection thresholds reduce the requirement for error correction. The purpose of this study was to model these two alternatives in healthy participants and to examine whether strategic control and subsequent aftereffects were abnormal compared to standard prism adaptation. Each participant completed three prism-adaptation procedures within a MIRAGE mediated reality environment with direction errors recorded before, during and after adaptation. During prism-adaptation, visual-feedback of the reach could be compressed, perturbed by noise or represented veridically. Compressed visual space significantly reduced strategic control and aftereffects compared to control and noise conditions. These results support recent observations in neglect patients, suggesting that a distortion of spatial representation may successfully model neglect and explain neglect performance while adapting to prisms.

  2. Trend of Hepatitis B Surface Antigen (HBsAg) among blood donors at the blood bank of a tertiary care referral teaching hospital in Southern India

    Yashovardhan A.; Sreedhar Babu K.V.; Jothi Bai D.S.

    2015-01-01

    Background: Blood is a scarce, but lifesaving resource; it is also the most efficient vehicle for the transmission of Hepatitis B virus (HBV). Hence there is a need for accurate screening of hepatitis B surface antigen (HBsAg) among blood donors. The present study was designed to assess the seroprevalence of HBsAg, among the voluntary and replacement blood donors in the blood bank of a tertiary care referral teaching hospital in Andhra Pradesh. Methods: This is a prospective cross sectiona...

  3. A comparison on HBsAg and HBsAb prevalence in patients with Down syndrome and other mentally retarded patients living in retarded children institutes in Tehran

    Sahebjamei M. Associate Professor

    2003-06-01

    Full Text Available Statement of Problem: The Prevalence of HBsAg, among patients with Down Syndrome (DS has been"nreported higher than normal population. Living in institutes, comparing to home, leads to higher"nprobability of HBsAg prevalence."nAim: The purpose of the present study was to determine HBsAg prevalence in patients with DS and"ncompare it with other mentally retarded patients with similar conditions, and also with healthy population"nin Iran."nMaterials and Methods: One hundred patients, with average age of 12 years, living in five institutes in"nTehran, were chosen. Children with DS and other mentally retarded children were considered as the first"nand second groups, respectively (50 members in each group. Blood samples were taken and tested"n(ELLSA to determine HBsAg and HBsAb titre. For statistical analysis, Chi- Square test was used."nResults: HBsAg was positive in 8% and 4% of DS and MR groups, respectively. HBsAb was seen in"n25% of DS, comparing to 32% of MR. The prevalence of HBsAg in retarded patients living in institutes"nwas higher than normal population of Iran (less than 3%, which was not statistically significant."nConclusion: Consideration of sterilization principles and infection control upon dental operations, in"nthese centers, are necessary. It is also suggested that these children, as a high- risk population, should be"nvaccinated against hepatitis B.

  4. Multicenter Evaluation of the New Abbott RealTime Assays for Quantitative Detection of Human Immunodeficiency Virus Type 1 and Hepatitis C Virus RNA▿

    Schutten, M.; Peters, D.; Back, N.K.T.; Beld, M; Beuselinck, K.; Foulongne, V.; Geretti, A.-M.; Pandiani, L.; Tiemann, C; Niesters, H.G.M.

    2007-01-01

    The analytical performances of the new Abbott RealTime hepatitis C virus (HCV) and human immunodeficiency virus type 1 viral load assays were compared at nine laboratories with different competitor assays. These included the Abbott LcX, Bayer Versant bDNA, Roche COBAS Amplicor, and Roche COBAS TaqMan assays. Two different protocols used during the testing period with and without a pre-m1000 RNA isolation spin were compared. The difference proved to be nonsignificant. A uracil-N-glycosylase (U...

  5. Comparison of the Abbott m2000 HIV-1 Real-Time and Roche AMPLICOR Monitor v1.5 HIV-1 assays on plasma specimens from Rakai, Uganda

    Ssebugenyi, I.; Kizza, A; Mpoza, B; Aluma, G.; Boaz, I.; Newell, K.; Laeyendecker, O; Shott, J P; Serwadda, D; Reynolds, S.J.

    2011-01-01

    The need for viral load (VL) monitoring of HIV patients receiving antiretroviral therapy (ART) in resource-limited settings (RLS) has become apparent with studies showing the limitations of immunological monitoring. We compared the Abbott m2000 Real-Time (Abbott) HIV-1 assay with the Roche AMPLICOR Monitor v1.5 (Roche) HIV-1 assay over a range of VL concentrations. Three hundred and eleven plasma samples were tested, including 164 samples from patients on ART ≥ six months and 147 from ART-naï...

  6. Abbott Aeroset全自动生化分析仪安装调试故障浅析

    苏娜; 胡远明

    2002-01-01

    @@ 我科于2001年11月28日安装了一台Abbott Aeroset全自动生化分析仪,在安装和调试期间出现的几例典型故障及其排除方法介绍如下,以供同行在使用该型号或同等档次的全自动生化分析仪时参考. Abbott Aeroset出厂时虽以整机装箱,在实验室安装时,安装部件只有近水管、4根废液管和2根加样针、4根试剂针加上搅拌器和比色杯以及工作站SCC,容易被工程师忽略整机中的其他部件,这就会导致一些很难觉察的故障.

  7. Mining the Digital Hamburg/ESO Objective Prism Survey

    Christlieb, N.; Wisotzki, L.; Reimers, D.

    2000-01-01

    We report on the exploitation of the stellar content of the Hamburg/ESO objective prism survey by quantitative selection methods, such as automatic spectral classification, and first results obtained.

  8. Recognizing Variable Environments The Theory of Cognitive Prism

    Dong, Tiansi

    2012-01-01

    Normal adults do not have any difficulty in recognizing their homes. But can artificial systems do in the same way as humans? This book collects interdisciplinary evidences and presents an answer from the perspective of computing, namely, the theory of cognitive prism. To recognize an environment, an intelligent system only needs to classify objects, structures them based on the connection relation (not through measuring!), subjectively orders the objects, and compares with the target environment, whose knowledge is similarly structured. The intelligent system works, therefore, like a prism: when a beam of light (a scene) reaches (is perceived) to an optical prism (by an intelligent system), some light (objects) is reflected (are neglected), those passed through (the recognized objects) are distorted (are ordered differently). So comes the term 'cognitive prism'! Two fundamental propositions used in the theory can be informally stated as follow: an orientation relation is a kind of distance comparison relatio...

  9. Strongly-Refractive One-Dimensional Photonic Crystal Prisms

    Ting, David Z. (Inventor)

    2004-01-01

    One-dimensional (1D) photonic crystal prisms can separate a beam of polychromatic electromagnetic waves into constituent wavelength components and can utilize unconventional refraction properties for wavelength dispersion over significant portions of an entire photonic band rather than just near the band edges outside the photonic band gaps. Using a ID photonic crystal simplifies the design and fabrication process and allows the use of larger feature sizes. The prism geometry broadens the useful wavelength range, enables better optical transmission, and exhibits angular dependence on wavelength with reduced non-linearity. The properties of the 1 D photonic crystal prism can be tuned by varying design parameters such as incidence angle, exit surface angle, and layer widths. The ID photonic crystal prism can be fabricated in a planar process, and can be used as optical integrated circuit elements.

  10. Dynamics of a microliquid prism actuated by electrowetting.

    Lee, Duck-Gyu; Park, Jaebum; Bae, Jungmok; Kim, Ho-Young

    2013-01-21

    A microliquid prism is a microchannel filled with two immiscible liquids, whose interface acts as a refractive surface. To steer a light beam that constructs optical images, the interface profile or the contact angle is modulated through electrowetting on a dielectric. Accurate, yet agile actuation of the liquid prism critically depends on the understanding of dynamics of the fluid interface. Here we fabricate liquid prisms, visualize the shape evolution of the interface, and theoretically model its dynamics. By comparing the magnitude of capillary forces to those of viscous, inertial and hydrostatic forces, we find that the meniscus motion within submillimetric channels is dominated by the capillary effect. The theoretical predictions for microscale meniscus dynamics are shown to agree well with the experimental measurements. We then discuss the formation of waves in millimetric liquid prisms, which may significantly limit fast and reliable operation of the optofluidic device. PMID:23165931

  11. Tricapped trigonal prism in crystal chemistry of oxygen lanthanide compounds

    It is shown that in the course of fragmentation of extreme coordination (CP)-icosahedron- 1 9-atom fragment (broken piece) appears to be one of the stages. Minimal transformations turn this 9-atom fragment into a tricapped trigonal prism. The latter represents the only extreme CP, which is built by monodentate acidoanions for the elements of the whole rare earth series. Statistic analysis of Ln-O interatomic distances in tricapped trigonal prisms is performed

  12. Spatial compression impairs prism-adaptation in healthy individuals

    Roger Newport

    2013-01-01

    Neglect patients typically present with gross inattention to one side of space following damage to the contralateral hemisphere. While prism-adaptation is effective in ameliorating some neglect behaviours, the mechanisms involved and their relationship to neglect remain unclear. Recent studies have shown that conscious strategic control processes in prism-adaptation may be impaired in neglect patients, who are also reported to show extraordinarily long aftereffects compared to healthy partici...

  13. Random Prism: a noise-tolerant alternative to Random Forests

    Stahl, Frederic; Bramer, Max

    2014-01-01

    Ensemble learning can be used to increase the overall classification accuracy of a classifier by generating multiple base classifiers and combining their classification results. A frequently used family of base classifiers for ensemble learning are decision trees. However, alternative approaches can potentially be used, such as the Prism family of algorithms that also induces classification rules. Compared with decision trees, Prism algorithms generate modular classification rules that cannot...

  14. Wedge Prism for Direction Resolved Speckle Correlation Interferometry

    The role of a wedge prism for strain sign determination and enhancing the sensitivity for sub-fringe changes is emphasized. The design and incorporation aspects for in-plane sensitive interferometers have been described in detail. Some experimental results dealing with stress determination by laser annealing and speckle correlation interferometry are presented. The prism can also be applied to produce standardized carrier fringes in spatial phase shifting interferometry

  15. Actinide recycle utilizing oxide and metallic fuel in prism

    PRISM is a modular, pool-type sodium-cooled fast reactor employing innovative, passive features to provide an extremely high level of public safety. The PRISM reactor design can accommodate both oxide and metallic fuel forms. A comparison of core design and performance of these forms is made for various options. These options include low fuel cycle cost options, maximum transuranic burning options, and the addition of rare earth elements to the fuel mix. (authors)

  16. k-Odd mean labeling of prism

    B. Gayathri

    2015-03-01

    Full Text Available ‎A $(p‎,‎q$ graph $G$ is said to have a $k$-odd mean‎ ‎labeling $(k ge 1$ if there exists an injection $f‎ : ‎V‎ ‎to {0‎, ‎1‎, ‎2‎, ‎ldots‎, ‎2k‎ + ‎2q‎ - ‎3}$ such that the‎ ‎induced map $f^*$ defined on $E$ by $f^*(uv =‎ ‎leftlceil frac{f(u+f(v}{2}rightrceil$ is a‎ ‎bijection from $E$ to ${2k - ‎‎‎1‎, ‎2k‎ + ‎1‎, ‎2k‎ + ‎3‎, ‎ldots‎, ‎2‎ ‎k‎ + ‎2q‎ - ‎3}$‎. ‎A graph that admits $k$-odd mean‎ ‎labeling is called $k$-odd mean graph‎. ‎In this paper‎, ‎we investigate $k$-odd mean labeling of prism $C_m times‎ ‎P_n$‎.

  17. PRISM: a planned risk information seeking model.

    Kahlor, LeeAnn

    2010-06-01

    Recent attention on health-related information seeking has focused primarily on information seeking within specific health and health risk contexts. This study attempts to shift some of that focus to individual-level variables that may impact health risk information seeking across contexts. To locate these variables, the researcher posits an integrated model, the Planned Risk Information Seeking Model (PRISM). The model, which treats risk information seeking as a deliberate (planned) behavior, maps variables found in the Theory of Planned Behavior (TPB; Ajzen, 1991) and the Risk Information Seeking and Processing Model (RISP; Griffin, Dunwoody, & Neuwirth, 1999), and posits linkages among those variables. This effort is further informed by Kahlor's (2007) Augmented RISP, the Theory of Motivated Information Management (Afifi & Weiner, 2004), the Comprehensive Model of Information Seeking (Johnson & Meischke, 1993), the Health Information Acquisition Model (Freimuth, Stein, & Kean, 1989), and the Extended Parallel Processing Model (Witte, 1998). The resulting integrated model accounted for 59% of the variance in health risk information-seeking intent and performed better than the TPB or the RISP alone. PMID:20512716

  18. Negative Refraction experiments in Photonic Crystal prisms

    Vodo, Plarenta; Parimi, Patanjali. V.; Lu, Wentao. T.; di Gennaro, Emiliano; Sridhar, Srinivas

    2004-03-01

    We have experimentally demonstrated negative refraction in metallic photonic crystal (PC) prisms [1]. The refracted fields in the parallel plate waveguide (PPW) are measured by an automated dipole antenna, which scans the desired area, while the free space (FS) measurements, performed in a anechoic chamber, are measured by a rectangular X-band horn that swings in an arc in far field area. Both TE and TM excitation modes are used in FS experiments. Numerical calculations of the band structure and equi-frequency surface simulations are used to determine frequency regions of negative refraction of the triangular lattice PC. Angle of refraction determined by theoretical simulations and experimental results, are in exceptional good agreement, yielding the negative refraction index. FS and PPW refraction experimental results agree remarkably with simulations. 1. "Negative Refraction and Left-handed electromagnetism in Microwave Photonic Crystals", P.V Parimi, W.T Lu, P.Vodo J. Sokoloff and S.Sridhar, cond-mat/0306109 (2003)

  19. Advanced prism-grating-prism imaging spectrograph in online industrial applications

    Vaarala, Tapio; Aikio, Mauri; Keraenen, Heimo

    1997-08-01

    Imaging spectrographs have traditionally been utilized in aerial and remote sensing applications. A novel, compact and inexpensive imaging spectrograph developed by VTT Electronics is now available. It contains a multichannel fiber optic sensor head, a dispersive prism-grating-prism (PGP) component and digital CCD matrix camera capable of area integration. In rolled steel manufacturing, a protective oil film is applied on steel to resist corrosion while in transport and storage. The main problems in the oiling machine are film thickness control and jet failures. In this application, the spectrum of fluorescence of an oil film was measured simultaneously with parallel fibers. A relatively simple calibration and analysis procedure was used to calculate the oil film thickness. On-line color control for color reproduction is essential in both consumer and industrial products. The instrument was tested and analyzed for measuring differences in color by multivariate analysis of the spectra and by color space coordinate estimation. In general, a continuous spectrum is not absolute requirement. In these two examples, filter-based measurement would probably cost less thana PGP spectrograph solution. On the other hand, by measuring the spectrum and using an advanced signal processing algorithm one production version will cover all installations in both applications. In practice, only the fiber sensor mechanics need to be modified.

  20. Virus-specific immune response in HBeAg-negative chronic hepatitis B: relationship with clinical profile and HBsAg serum levels.

    Elisabetta Loggi

    Full Text Available BACKGROUND AIMS: The immune impairment characterizing chronic hepatitis B (cHBV infection is thought to be the consequence of persistent exposure to viral antigens. However, the immune correlates of different clinical stages of cHBV and their relation with different levels of HBsAg have not been investigated. The aim of the present study was to evaluate the relationship between HBV-specific T cells response and the degree of in vivo HBV control and HBsAg serum levels in HBeAg-HBeAb+ cHBV. METHODS: Peripheral blood mononuclear cells from 42 patients with different clinical profiles (treatment-suppressed, inactive carriers and active hepatitis of cHBV, 6 patients with resolved HBV infection and 10 HBV-uninfected individuals were tested with overlapping peptides spanning the entire HBV proteome. The frequency and magnitude of HBV-specific T cell responses was assessed by IFNγ ELISPOT assay. Serum HBsAg was quantified with a chemiluminescent immunoassay. RESULTS: The total breadth and magnitude of HBV-specific T cell responses did not differ significantly between the four groups. However, inactive carriers targeted preferentially the core region. In untreated patients, the breadth of the anti-core specific T cell response was inversely correlated with serum HBsAg concentrations as well as HBV-DNA and ALT levels and was significantly different in patients with HBsAg levels either above or below 1000 IU/mL. The same inverse association between anti-core T cell response and HBsAg levels was found in treated patients. CONCLUSIONS: Different clinical outcomes of cHBV infection are associated with the magnitude, breadth and specificity of the HBV-specific T cell response. Especially, robust anti-core T cell responses were found in the presence of reduced HBsAg serum levels, suggesting that core-specific T cell responses can mediate a protective effect on HBV control.

  1. Immune responses to HBsAg conjugated to protein D of non-typeable Haemophilus influenzae in mice.

    Qiudong Su

    Full Text Available Hepatitis B vaccine that contains an aluminum hydroxide adjuvant induces apoptotic death of Hepa 1-6 cells. Difficult-to-degrade chemical additives in vaccines effectively enhance vaccine immunogenicity, but also affect the host tissue. Identification of bio-molecules that are readily degraded and compatible in vivo as an adjuvant is important for vaccine research. The hapten-carrier effect suggests that stimulation of helper T (Th cells by carrier adjuvants is feasible. Protein D (PD of non-typeable Haemophilus influenzae covalently conjugated to some polysaccharide vaccines has been confirmed to convert T-cell independent (TI antigens into T-cell dependent (TD antigens, and elicit strong T-cell responses ultimately. Herein, we would substitube PD for aluminum hydroxide adjuvant in Hepatitis B vaccine.Truncated PD (amino acids 20-364 was expressed in Escherichia coli and purified by (NH42SO4 precipitation and DEAE chromatography. After evaluation of antigenicity by western blotting, PD was covalently conjugated to yeast-derived recombinant HBsAg by cross-linking with glutaraldehyde. Intramuscular immunization with the conjugate induced higher level of HBsAg-specific antibody than did HBsAg alone (p < 0.05, and was comparable to commercial Hepatitis B vaccine. During the surveillance period (days 35-105, anti-HBs titers were hold high. Moreover, the conjugated vaccine enhanced Th1 immune responses, while Th2 responses were also activated and induced an antibody response, as determined by IFN-γ ELISPOT and IgG1/IgG2a ratio assays.Recombinant truncated PD covalently conjugated to HBsAg antigen enhanced the immunogenicity of the antigen in mice simultaneously by humoral and cellular immune response, which would facilitate therapeutic hepatitis B vaccines.

  2. Comparison of Perceptions of "Preparedness" of John Abbott C.E.G.E.P. Nursing Graduates: Prior to Graduation and After.

    Iton, Carmen; Sabiston, Judy

    A study of John Abbott College's nursing graduates was conducted to determine how well prepared for their professional responsibilities the graduates saw themselves just prior to graduation and later after working in the nursing field. A sample of 98 nursing students who graduated between 1986 and 1988 was surveyed, with 93% responding to the…

  3. ELISA法检测HBsAg假阳性原因分析%Analysis of ELISA Method for Detection of HBsAg False Positive

    奚焕琴

    2014-01-01

    Objective Detection of HBsAg ELISA method to cause false positive.Methods Col ection of 160 cases of ELISA was detected in HBsAg positive specimens were detected by col oidal gold method, the two do not meet, re were ELISA and col oidal gold method review.Results The initial inspection in 160 HBsAg positive cases and 7 false positive .Conclusion Detection of HBsAg ELISA is af ected by many factors, only to master the detection of HBsAg ELISA factors causing false positive, can reduce errors and accidents at work.%目的了解ELISA法检测HBsAg造成假阳性的原因。方法采集160例ELISA法检测HBsAg阳性标本进行胶体金法检测,二者不符合者,重新抽血进行ELISA和胶体金法复检。结果初检160例HBsAg阳性标本有7例假阳性。结论 ELISA法检测HBsAg受多种因素影响,只有掌握ELISA法检测HBsAg造成假阳性的影响因素,才能在工作中减少差错事故。

  4. Prism-based single-camera system for stereo display

    Zhao, Yue; Cui, Xiaoyu; Wang, Zhiguo; Chen, Hongsheng; Fan, Heyu; Wu, Teresa

    2016-06-01

    This paper combines the prism and single camera and puts forward a method of stereo imaging with low cost. First of all, according to the principle of geometrical optics, we can deduce the relationship between the prism single-camera system and dual-camera system, and according to the principle of binocular vision we can deduce the relationship between binoculars and dual camera. Thus we can establish the relationship between the prism single-camera system and binoculars and get the positional relation of prism, camera, and object with the best effect of stereo display. Finally, using the active shutter stereo glasses of NVIDIA Company, we can realize the three-dimensional (3-D) display of the object. The experimental results show that the proposed approach can make use of the prism single-camera system to simulate the various observation manners of eyes. The stereo imaging system, which is designed by the method proposed by this paper, can restore the 3-D shape of the object being photographed factually.

  5. Study of dose calculation on breast brachytherapy using prism TPS

    PRISM is one of non-commercial Treatment Planning System (TPS) and is developed at the University of Washington. In Indonesia, many cancer hospitals use expensive commercial TPS. This study aims to investigate Prism TPS which been applied to the dose distribution of brachytherapy by taking into account the effect of source position and inhomogeneities. The results will be applicable for clinical Treatment Planning System. Dose calculation has been implemented for water phantom and CT scan images of breast cancer using point source and line source. This study used point source and line source and divided into two cases. On the first case, Ir-192 seed source is located at the center of treatment volume. On the second case, the source position is gradually changed. The dose calculation of every case performed on a homogeneous and inhomogeneous phantom with dimension 20 × 20 × 20 cm3. The inhomogeneous phantom has inhomogeneities volume 2 × 2 × 2 cm3. The results of dose calculations using PRISM TPS were compared to literature data. From the calculation of PRISM TPS, dose rates show good agreement with Plato TPS and other study as published by Ramdhani. No deviations greater than ±4% for all case. Dose calculation in inhomogeneous and homogenous cases show similar result. This results indicate that Prism TPS is good in dose calculation of brachytherapy but not sensitive for inhomogeneities. Thus, the dose calculation parameters developed in this study were found to be applicable for clinical treatment planning of brachytherapy

  6. Study of dose calculation on breast brachytherapy using prism TPS

    Fendriani, Yoza; Haryanto, Freddy

    2015-09-01

    PRISM is one of non-commercial Treatment Planning System (TPS) and is developed at the University of Washington. In Indonesia, many cancer hospitals use expensive commercial TPS. This study aims to investigate Prism TPS which been applied to the dose distribution of brachytherapy by taking into account the effect of source position and inhomogeneities. The results will be applicable for clinical Treatment Planning System. Dose calculation has been implemented for water phantom and CT scan images of breast cancer using point source and line source. This study used point source and line source and divided into two cases. On the first case, Ir-192 seed source is located at the center of treatment volume. On the second case, the source position is gradually changed. The dose calculation of every case performed on a homogeneous and inhomogeneous phantom with dimension 20 × 20 × 20 cm3. The inhomogeneous phantom has inhomogeneities volume 2 × 2 × 2 cm3. The results of dose calculations using PRISM TPS were compared to literature data. From the calculation of PRISM TPS, dose rates show good agreement with Plato TPS and other study as published by Ramdhani. No deviations greater than ±4% for all case. Dose calculation in inhomogeneous and homogenous cases show similar result. This results indicate that Prism TPS is good in dose calculation of brachytherapy but not sensitive for inhomogeneities. Thus, the dose calculation parameters developed in this study were found to be applicable for clinical treatment planning of brachytherapy.

  7. Reverse time migration of prism waves for salt flank delineation

    Dai, Wei

    2013-09-22

    In this paper, we present a new reverse time migration method for imaging salt flanks with prism wave reflections. It consists of four steps: (1) migrating the seismic data with conventional RTM to give the RTM image; (2) using the RTM image as a reflectivity model to simulate source-side reflections with the Born approximation; (3) zero-lag correlation of the source-side reflection wavefields and receiver-side wavefields to produce the prism wave migration image; and (4) repeating steps 2 and 3 for the receiver-side reflections. An advantage of this method is that there is no need to pick the horizontal reflectors prior to migration of the prism waves. It also separately images the vertical structures at a different step to reduce crosstalk interference. The disadvantage of prism wave migration algorithm is that its computational cost is twice that of conventional RTM. The empirical results with a salt model suggest that prism wave migration can be an effective method for salt flank delineation in the absence of diving waves.

  8. Nuclear medicine gamma camera system PRISM-XP series

    Recently, SPECT gamma camera systems have become important in RI imaging of the brain and torso. The PRISM-XP series is a new SPECT system which employs multiple detectors, a fan beam collimator and a non-circular orbit for improved acquisition speed and sensitivity. For improved data processing, this machine uses a 64-bit CPU and a 3D graphics subsystem specially designed for image processing. The PRISM-XP series also includes 3-detector, 2-detector and 1-detector systems. The dual and single detector systems also have functions for whole-body imaging. In this article, the PRISM-XP series, which is commercialized by PICKER International Inc, Ohio, U.S.A., is presented. (author)

  9. Advanced hyperspectral video imaging system using Amici prism.

    Feng, Jiao; Fang, Xiaojing; Cao, Xun; Ma, Chenguang; Dai, Qionghai; Zhu, Hongbo; Wang, Yongjin

    2014-08-11

    In this paper, we propose an advanced hyperspectral video imaging system (AHVIS), which consists of an objective lens, an occlusion mask, a relay lens, an Amici prism and two cameras. An RGB camera is used for spatial reading and a gray scale camera is used for measuring the scene with spectral information. The objective lens collects more light energy from the observed scene and images the scene on an occlusion mask, which subsamples the image of the observed scene. Then, the subsampled image is sent to the gray scale camera through the relay lens and the Amici prism. The Amici prism that is used to realize spectral dispersion along the optical path reduces optical distortions and offers direct view of the scene. The main advantages of the proposed system are improved light throughput and less optical distortion. Furthermore, the presented configuration is more compact, robust and practicable. PMID:25321019

  10. Birefringent neutron prisms for spin echo scattering angle measurement

    Pynn, Roger, E-mail: rpynn@indiana.ed [Indiana University, Bloomington, IN (United States); Oak Ridge National Laboratory, Oak Ridge, TN (United States); Fitzsimmons, M.R. [Los Alamos National Laboratory, Los Alamos, NM (United States); Lee, W.T. [Oak Ridge National Laboratory, Oak Ridge, TN (United States); Stonaha, P.; Shah, V.R.; Washington, A.L. [Indiana University, Bloomington, IN (United States); Kirby, B.J.; Majkrzak, C.F.; Maranville, B.B. [National Institute of Standards and Technology (United States)

    2009-09-01

    In the first decade of the 19th century, an English chemist, William Wollaston, invented an arrangement of birefringent prisms that splits a beam of light into two spatially separated beams with orthogonal polarizations. We have constructed similar devices for neutrons using triangular cross-section solenoids and employed them for Spin Echo Scattering Angle Measurement (SESAME). A key difference between birefringent neutron prisms and their optical analogues is that it is hard to embed the former in a medium which has absolutely no birefringence because this implies the removal of all magnetic fields. We have overcome this problem by using the symmetry properties of the Wollaston neutron prisms and of the overall spin echo arrangement. These symmetries cause a cancellation of Larmor phase aberrations and provide robust coding of neutron scattering angles with simple equipment.

  11. Transmission and Distribution of Optical Field in Prism Coupler

    Transmission and distribution characteristics of optical field in prism coupler are studies, and the phase matching function of prism coupler is deduced based on coupled wave theory. It is shown that the stable light field distribution and mode pattern are determined by its own geometric and dielectric parameters, but have nothing to do with the categories of incident light sources. It is also found that the coupling effect would generate between waveguides through evanescent field. Our numerical simulation is based on the finite difference time domain method with perfectly matched layer absorbing boundary condition. The simulation program is compiled in MATLAB. The simulation results are analyzed carefully.

  12. Temperature Influence on Divergence Angles of Quartz Crystal Wollaston Prism

    We propose a structural angle and main refractive indices as two key factors to understand the temperature influence on the divergence angles of the Wollaston prism. The temperature influence on the divergence angles of quartz crystal Wollaston prism is studied theoretically The results show that divergence angles decrease with increasing temperature, while the divergence angle of e-light decrease more quickly than that of o-light. The testing system is established to verify the above results, and the experimental results are in agreement well with the theoretical analysis. (fundamental areas of phenomenology (including applications))

  13. Assessment of PRISM responses to loss of flow events

    The Nuclear Regulatory Commission (NRC), with Brookhaven National Laboratory providing technical support, is continuing a preapplication review of the 471 MWt, Advanced Liquid Metal Reactor (ALMR), PRISM by General Electric. The revised design has been evaluated using the SSC code, for a series of loss of flow events (LOF) with and without Gas Expansion Modules (GEMs). These devices have a net worth of 69 cents and have reduced the seriousness of the LOF in PRISM. However, it was found that the extremely low probability case of an instantaneous loss of 4 EM pumps without scram could lead to sodium boiling even with the GEMs. (author)

  14. Prism refractive index measurement at INRiM

    A simple method to measure the refractive index of a glass prism with very low uncertainty was developed at INRiM. The method is a modification of the classical minimum deviation method. A brief description of the methods used to measure the vertex angles of the prism and the angle of minimum deviation is reported together with the uncertainty evaluation. The technique is going to be validated by a comparison between INRiM and two other laboratories. A relative standard uncertainty better than 1 ppm has been obtained

  15. Quartz-Enhanced Photoacoustic Spectroscopy with Right-Angle Prism

    Yongning Liu; Jun Chang; Jie Lian; Zhaojun Liu; Qiang Wang; Zengguang Qin

    2016-01-01

    A right-angle prism was used to enhance the acoustic signal of a quartz-enhanced photoacoustic spectroscopy (QEPAS) system. The incident laser beam was parallelly inverted by the right-angle prism and passed through the gap between two tuning fork prongs again to produce another acoustic excitation. Correspondingly, two pairs of rigid metal tubes were used as acoustic resonators with resonance enhancement factors of 16 and 12, respectively. The QEPAS signal was enhanced by a factor of 22.4 co...

  16. Intricacies of Feedback in Computer-based Prism Adaptation Therapy

    Wilms, Inge Linda; Rytter, Hana Malá

    Prism Adaptation Therapy (PAT) is an intervention method for treatment of attentional disorders, such as neglect e.g. 1,2. The method involves repeated pointing at specified targets with or without prism glasses using a specifically designed wooden box. The aim of this study was to ascertain...... direct feedback (physical finger) on pointing precision. Attempts to provide feedback indirectly via icons on the computer screen fail to create the aftereffects observed in the original PAT. The findings have direct implications for future implementations of computer-based methods in treatment of...

  17. Enhancement of humoral immune responses to HBsAg by heat shock protein gp96 and its N-terminal fragment in mice

    Hong-Tao Li; Jia-Bin Yan; Jing Li; Ming-Hai Zhou; Xiao-Dong Zhu; Yu-Xia Zhang; Po Tien

    2005-01-01

    AIM: Most studies on the immune effect of gp96 were focused on its enhancement of CTLs. It is interesting to know whether gp96 could influence the humoral immune response, and whether the recombinant N-terminal fragment of gp96 could substitute native gp96 to stimulate the immune system.METHODS: gp96 isolated from livers of normal mice and its N-terminal fragment (amino acid 22-355) expressed in E coli were used for immunization of BALb/c mice. Eight groups of mice received one of the following regiments subcutaneously in 100 μL phosphate buffered saline (PBS)at an interval of 3 wk. Group 1: PBS only; group 2:gp96 only; group 3: N-terminal fragment only; group 4: HBsAg only; group 5: HBsAg+gp96; group 6: HBsAg+N-terminalfragment; group 7: HBsAg+incomplete Freud's adjuvant; group 8: HBsAg+N-terminal fragment (95 ℃ heated for 30 min). Serum anti-HBsAg antibody levels were assayed by ELISA. CTL responses in splenocytes were analyzed by ELISPOT after the last vaccination.RESULTS: The average titer of serum anti-HBsAg antibodyin the mice immunized with HBsAg together with gp96 or its N-terminal fragment were much higher than those immunized with HBsAg alone detected by ELISA. The cellular immune response of the mice immunized with HBsAg together with gp96 or its N-terminal fragment was not different with those immunized with HBsAg alone measured by ELISPOT assay.CONCLUSION: gp96 or its N-terminal fragment greatly improved humoral immune response induced by HBsAg, but failed to enhance the CTL response, which demonstrated the potential of using gp96 or its N-terminal fragment as a possible adjuvant to augment humoral immune response against HBV infection.

  18. Prediction of conformational changes by single mutation in the hepatitis B virus surface antigen (HBsAg identified in HBsAg-negative blood donors

    Roni Martono

    2010-11-01

    Full Text Available Abstract Background Selection of hepatitis B virus (HBV by host immunity has been suggested to give rise to variants with amino acid substitutions at or around the 'a' determinant of the surface antigen (HBsAg, the main target of antibody neutralization and diagnostic assays. However, there have never been successful attempts to provide evidence for this hypothesis, partly because the 3 D structure of HBsAg molecules has not been determined. Tertiary structure prediction of HBsAg solely from its primary amino acid sequence may reveal the molecular energetic of the mutated proteins. We carried out this preliminary study to analyze the predicted HBsAg conformation changes of HBV variants isolated from Indonesian blood donors undetectable by HBsAg assays and its significance, compared to other previously-reported variants that were associated with diagnostic failure. Results Three HBV variants (T123A, M133L and T143M and a wild type sequence were analyzed together with frequently emerged variants T123N, M133I, M133T, M133V, and T143L. Based on the Jameson-Wolf algorithm for calculating antigenic index, the first two amino acid substitutions resulted in slight changes in the antigenicity of the 'a' determinant, while all four of the comparative variants showed relatively more significant changes. In the pattern T143M, changes in antigenic index were more significant, both in its coverage and magnitude, even when compared to variant T143L. These data were also partially supported by the tertiary structure prediction, in which the pattern T143M showed larger shift in the HBsAg second loop structure compared to the others. Conclusions Single amino acid substitutions within or near the 'a' determinant of HBsAg may alter antigenicity properties of variant HBsAg, which can be shown by both its antigenic index and predicted 3 D conformation. Findings in this study emphasize the significance of variant T143M, the prevalent isolate with highest degree of

  19. Cerebellar inactivation impairs memory of learned prism gaze-reach calibrations

    Norris, Scott A.; Hathaway, Emily N.; Taylor, Jordan A.; Thach, W. Thomas

    2011-01-01

    Three monkeys performed a visually guided reach-touch task with and without laterally displacing prisms. The prisms offset the normally aligned gaze/reach and subsequent touch. Naive monkeys showed adaptation, such that on repeated prism trials the gaze-reach angle widened and touches hit nearer the target. On the first subsequent no-prism trial the monkeys exhibited an aftereffect, such that the widened gaze-reach angle persisted and touches missed the target in the direction opposite that o...

  20. A high throughput (>90%), large compensation range, single-prism femtosecond pulse compressor

    Kong, Lingjie; Cui, Meng

    2013-01-01

    We demonstrate a high throughput, large compensation range, single-prism femtosecond pulse compressor, using a single prism and two roof mirrors. The compressor has zero angular dispersion, zero spatial dispersion, zero pulse-front tilt, and unity magnification. The high efficiency is achieved by adopting two roof mirrors as the retroreflectors. We experimentally achieved ~ -14500 fs2 group delay dispersion (GDD) with 30 cm of prism tip-roof mirror prism separation, and ~90.7% system throughp...

  1. Cardiac rate detection method based on the beam splitter prism

    Yang, Lei; Liu, Xiaohua; Liu, Ming; Zhao, Yuejin; Dong, Liquan; Zhao, Ruirui; Jin, Xiaoli; Zhao, Jingsheng

    2013-09-01

    A new cardiac rate measurement method is proposed. Through the beam splitter prism, the common-path optical system of transmitting and receiving signals is achieved. By the focusing effect of the lens, the small amplitude motion artifact is inhibited and the signal-to-noise is improved. The cardiac rate is obtained based on the PhotoPlethysmoGraphy (PPG). We use LED as the light source and use photoelectric diode as the receiving tube. The LED and the photoelectric diode are on the different sides of the beam splitter prism and they form the optical system. The signal processing and display unit is composed by the signal processing circuit, data acquisition device and computer. The light emitted by the modulated LED is collimated by the lens and irradiates the measurement target through the beam splitter prism. The light reflected by the target is focused on the receiving tube through the beam splitter prism and another lens. The signal received by the photoelectric diode is processed by the analog circuit and obtained by the data acquisition device. Through the filtering and Fast Fourier Transform, the cardiac rate is achieved. We get the real time cardiac rate by the moving average method. We experiment with 30 volunteers, containing different genders and different ages. We compare the signals captured by this method to a conventional PPG signal captured concurrently from a finger. The results of the experiments are all relatively agreeable and the biggest deviation value is about 2bmp.

  2. The Pacific Oaks College's Prism Principles Professional Development Approach

    Beyer, Kalani

    2012-01-01

    In a struggling atmosphere for education, one college is optimistic about the future by offering school districts its PRISM Principles professional development as a means to ensure that "no child is left behind." Pacific Oaks College & Children's School is known for its premiere programs in early childhood education, human…

  3. Portable Remote Imaging Spectrometer (PRISM): Laboratory and Field Calibration

    Mouroulis, Pantazis; Van Gorp, Byron; Green, Robert O.; Eastwood, Michael; Boardman, Joseph; Richardson, Brandon S.; Rodriguez, Jose I.; Urquiza, Eugenio; Franklin, Brian D.; Gao, Bo-Cai

    2012-01-01

    We report the characteristics of the Portable Remote Imaging Spectrometer, an airborne sensor specifically designed for the challenges of coastal ocean research. PRISM has high signal to noise ratio and uniformity, as well as low polarization sensitivity. Acquisition of high quality data has been demonstrated with the first engineering flight.

  4. Programmable agile beam steering based on a liquid crystal prism

    To meet the application need for agile precision beam steering, a novel liquid crystal prism device with a simple structure, convenient control, low cost and applicable performance is presented, and analysed theoretically and experimentally. The relationships between the optical path and the thickness of the liquid crystal cell under different voltages are investigated quantitatively by using a theoretical model. Analysis results show that the optical path profile of the liquid crystal prism has a quasi-linear slope and the standard deviation of the linear slope is less than 16 nm. The slope ratio can be changed by a voltage, which achieves the programmable beam steering and control. Practical liquid crystal prism devices are fabricated. Their deflection angles and wavefront profiles with different voltages are experimentally tested. The results are in good agreement with the simulated results. The results imply that the agile beam steering in a scope of 100 μrad with a micro-rad resolution is substantiated in the device. The two-dimensional beam steering is also achieved by cascading two liquid crystal prism devices. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  5. First Observation of Neutron Deflections by Single Crystal Prisms

    For a monochromatic neutron beam incident on a single crystal prism, we derived analytic expressions for variations of the deflection δcr and transmitted fraction IO of forward diffracted neutrons, with the incidence angle θ. In the vicinity of a Bragg reflection, δcr deviates sharply from the deflection δam for an equivalent amorphous prism, reaching opposite extrema at either end of the total reflectivity domain and exhibits a 3 orders of magnitude greater sensitivity to θ than δam. We have experimentally observed the variation of δcr and IO across a Bragg reflection for single crystal silicon prisms of various apex angles in several asymmetric Bragg configurations. The observed δcr deviates from δam by upto 27% with sensitivities |dδcr/dθ| upto 0.43 arcsec/arcsec. The results are in harmony with theory. This observation has led to the design of a super-collimator Bragg prism producing neutron beams with sub-arcsecond angular widths.

  6. Astigmatism and coma-free prism dye ring laser

    The characteristics of two prism ring lasers for cw operation have been experimentally studied. With improved compensation for aberrations due to astigmatism and coma, cw ring lasers operated in the traveling-wave mode provide high output efficiency, stable narrow bandwidth in multimode and single-mode operation, and a broad tuning range

  7. THz Photonic Band-Gap Prisms Fabricated by Fiber Drawing

    Busch, Stefan F.; Xu, Lipeng; Stecher, Matthias;

    2012-01-01

    We suggest a novel form of polymeric based 3D photonic crystal prisms for THz frequencies which could be fabricated using a standard fiber drawing technique. The structures are modeled and designed using a finite element analyzing technique. Using this simulation software we theoretically study...... their performance....

  8. The demagnetizing field of a non-uniform rectangular prism

    Smith, Anders; Nielsen, Kaspar Kirstein; Christensen, Dennis;

    2010-01-01

    The effect of demagnetization on the magnetic properties of a rectangular ferromagnetic prism under non-uniform conditions is investigated. A numerical model for solving the spatially varying internal magnetic field is developed, validated and applied to relevant cases. The demagnetizing field is......-uniformity of the internal field, especially for non-constant temperature distributions and composite magnetic materials....

  9. A decomposition theorem for binary matroids with no prism minor

    Kingan, Sandra

    2012-01-01

    The prism graph is the dual of the complete graph on five vertices with an edge deleted, $K_5\\backslash e$. In this paper we determine the class of binary matroids with no prism minor. The motivation for this problem is the 1963 result by Dirac where he identified the simple 3-connected graphs with no minor isomorphic to the prism graph. We prove that besides Dirac's infinite families of graphs and four infinite families of non-regular matroids determined by Oxley, there are only three possibilities for a matroid in this class: it is isomorphic to the dual of the generalized parallel connection of $F_7$ with itself across a triangle with an element of the triangle deleted; it's rank is bounded by 5; or it admits a non-minimal exact 3-separation induced by the 3-separation in $P_9$. Since the prism graph has rank 5, the class has to contain the binary projective geometries of rank 3 and 4, $F_7$ and $PG(3, 2)$, respectively. We show that there is just one rank 5 extremal matroid in the class. It has 17 element...

  10. Coxeter Decompositions of Bounded Hyperbolic Pyramids and Triangular Prisms

    Felikson, A.

    2002-01-01

    Coxeter decompositions of hyperbolic simplices where studied in math.MG/0212010 and math.MG/0210067. In this paper we use the methods of these works to classify Coxeter decompositions of bounded convex pyramids and triangular prisms in the hyperbolic space H^3.

  11. Electrowetting-Controlled Dual Liquid Prism for Adaptive Beam Steering

    Cheng, Jiangtao

    2015-03-01

    The use of concentrating photovoltaic (CPV) technology has been the most promising method of harvesting solar radiation. These CPV systems often require motor-driven tracking devices to steer the sun's beams onto solar cells. The cost of maintaining these tracking systems is the primary inhibitor for widespread application. We aim to overcome the need for mechanical trackers through the use of an electrowetting-driven solar tracking (EWST) system. The electrowetting-driven solar tracking system consists of an array of novel electrowetting-controlled dual liquid prisms, which are filled with immiscible fluids that have large differences in refractive indices. The naturally formed meniscus between the fluids can function as a dynamic optical prism. Via the full-range modulation of the liquid prisms, incident sunlight can be adaptively tracked, steered, and focused onto CPV cells through a fixed optical condenser. Furthermore, unlike the conventional and cumbersome motor-driven tracking systems used today, the liquid prism system would be suitable for rooftop applications. The results of this project reveal that the EWST system has the potential to generate ~ 70% more green energy at 50% of the conventional capital cost.

  12. Superconducting magnetic Wollaston prism for neutron spin encoding

    A magnetic Wollaston prism can spatially split a polarized neutron beam into two beams with different neutron spin states, in a manner analogous to an optical Wollaston prism. Such a Wollaston prism can be used to encode the trajectory of neutrons into the Larmor phase associated with their spin degree of freedom. This encoding can be used for neutron phase-contrast radiography and in spin echo scattering angle measurement (SESAME). In this paper, we show that magnetic Wollaston prisms with highly uniform magnetic fields and low Larmor phase aberration can be constructed to preserve neutron polarization using high temperature superconducting (HTS) materials. The Meissner effect of HTS films is used to confine magnetic fields produced electromagnetically by current-carrying HTS tape wound on suitably shaped soft iron pole pieces. The device is cooled to ∼30 K by a closed cycle refrigerator, eliminating the need to replenish liquid cryogens and greatly simplifying operation and maintenance. A HTS film ensures that the magnetic field transition within the prism is sharp, well-defined, and planar due to the Meissner effect. The spin transport efficiency across the device was measured to be ∼98.5% independent of neutron wavelength and energizing current. The position-dependent Larmor phase of neutron spins was measured at the NIST Center for Neutron Research facility and found to agree well with detailed simulations. The phase varies linearly with horizontal position, as required, and the neutron beam shows little depolarization. Consequently, the device has advantages over existing devices with similar functionality and provides the capability for a large neutron beam (20 mm × 30 mm) and an increase in length scales accessible to SESAME to beyond 10 μm. With further improvements of the external coupling guide field in the prototype device, a larger neutron beam could be employed

  13. Prism adaptation contrasts perceptual habituation for repetitive somatosensory stimuli.

    Torta, D M; Tatu, M K; Cotroneo, D; Alamia, A; Folegatti, A; Trojan, J

    2016-03-01

    Prism adaptation (PA) is a non-invasive procedure that requires performing a visuo-motor pointing task while wearing prism goggles inducing a visual displacement of the pointed target. This procedure involves a reorganization of sensorimotor coordination, and induces long-lasting effects on numerous higher-order cognitive functions in healthy volunteers and neglect patients. Prismatic displacement (PD) of the visual field can be induced when prisms are worn but no sensorimotor task is required. In this case, it is unlikely that any subsequent reorganization takes place. The effects of PD are short-lived in the sense that they last as long as prisms are worn. In this study we aimed, to the best of our knowledge for the first time, at investigating whether PA and PD induce changes in the perception of intensity of nociceptive and non- nociceptive somatosensory stimuli. We induced, in healthy volunteers, PD (experiment 1), or PA (experiment 2) and asked participants to rate the intensity of the stimuli applied to the hand undergoing the visuo-proprioceptive conflict (experiment 1) or adaptation (experiment 2). Our results indicate that: 1) the visuo-proprioceptive conflict induced by PD does not reduce the perceived intensity of the stimuli, 2) PA prevents perceptual habituation for both nociceptive and non-nociceptive somatosensory stimuli. Moreover, to investigate the possible underlying mechanisms of the effects of PA we conducted a third experiment in which stimuli were applied both at the adapted and the non-adapted hand. In line with the results of experiment 2, we found that perceptual habituation was prevented for stimuli applied onto the adapted hand. Moreover, we observed the same finding for stimuli applied onto the non-adapted hand. This result suggests that the detention of habituation is not merely driven by changes in spatial attention allocation. Taken together, these data indicate that prisms can affect the perceived intensity of somatosensory stimuli

  14. Study of dose calculation on breast brachytherapy using prism TPS

    Fendriani, Yoza; Haryanto, Freddy [Nuclear Physics and Biophysics Research Division, FMIPA Institut Teknologi Bandung, Physics Buildings, Jl. Ganesha 10, Bandung 40132 (Indonesia)

    2015-09-30

    PRISM is one of non-commercial Treatment Planning System (TPS) and is developed at the University of Washington. In Indonesia, many cancer hospitals use expensive commercial TPS. This study aims to investigate Prism TPS which been applied to the dose distribution of brachytherapy by taking into account the effect of source position and inhomogeneities. The results will be applicable for clinical Treatment Planning System. Dose calculation has been implemented for water phantom and CT scan images of breast cancer using point source and line source. This study used point source and line source and divided into two cases. On the first case, Ir-192 seed source is located at the center of treatment volume. On the second case, the source position is gradually changed. The dose calculation of every case performed on a homogeneous and inhomogeneous phantom with dimension 20 × 20 × 20 cm{sup 3}. The inhomogeneous phantom has inhomogeneities volume 2 × 2 × 2 cm{sup 3}. The results of dose calculations using PRISM TPS were compared to literature data. From the calculation of PRISM TPS, dose rates show good agreement with Plato TPS and other study as published by Ramdhani. No deviations greater than ±4% for all case. Dose calculation in inhomogeneous and homogenous cases show similar result. This results indicate that Prism TPS is good in dose calculation of brachytherapy but not sensitive for inhomogeneities. Thus, the dose calculation parameters developed in this study were found to be applicable for clinical treatment planning of brachytherapy.

  15. Sediment compaction and fluid migration in the Makran Accretionary Prism

    Minshull, Tim; White, Robert

    1989-06-01

    The Makran continental margin in the Gulf of Oman forms the seaward extremity of an accretionary sediment prism which extends several hundred kilometers inland. A recently acquired multichannel seismic reflection profile shot across the margin imaged the structure of the prism in greater detail than was previously possible and allowed us to investigate the relationship between deformation and pore fluid motion in the region. Velocity analyses of the common midpoint gathers reveal a marked change in velocity structure at the toe of the accretionary wedge, as seen in previous sonobuoy wide-angle data. Accreted sediments show significantly higher vertical velocity gradients than those of sediments entering the prism; this change is interpreted as due to porosity reduction as pore fluids are squeezed out of the compacting sediment. A prominent "bottom simulating reflector" appears 500-800 m beneath the sea bed. Several lines of evidence suggest that this reflector represents the base of a gas hydrate zone underlain by widespread free gas, which may be exsolved from pore water migrating from deep within the sediment pile up permeable fault planes imaged in the profile. The hydrate reflector appears to shallow in the region of some faults, suggesting a temperature anomaly due to the presence of warm pore fluids. A heat flow profile derived from the depth of the hydrate reflector does not show the expected landward decrease as the sediment pile thickens. Simple thermal modeling suggests that advective heat flow within the prism may explain this anomaly. The inferred presence of overpressured pore fluids in the Makran suggests that accreted sediments have a low permeability. The seismic evidence suggests a two-stage compaction process, with rapid initial dewatering through intergranular permeability as sediment enters the prism followed by a buildup of pore pressure as the permeability decreases and fluid migration is restricted to fault zones.

  16. Efficient Quantification of HIV-1 in Heparin Plasma Spiked with Cultured HIV-1 by the Roche Cobas TaqMan and Abbott RealTime HIV-1 Tests

    Jagodzinski, Linda L; Weston, Holly R.; Liu, Ying; O'Connell, Robert J.; Peel, Sheila A

    2012-01-01

    The current automated real-time HIV-1 viral load assays, the Roche Cobas AmpliPrep/Cobas TaqMan test and the Abbott RealTime test, are FDA cleared for use with EDTA plasma. We show that both real-time reverse transcription-PCR (RT-PCR) tests reliably quantify HIV-1 RNA in heparin plasma specimens spiked with HIV-1 isolate MN.

  17. Abbott RealTime HIV-1 m2000rt viral load testing: Manual extraction versus the automated m2000sp extraction

    Scott, Lesley E.; Crump, John A.; Msuya, Emma; Morrissey, Anne B.; Venter, Willem F.; Stevens, Wendy S.

    2010-01-01

    The Abbott RealTime HIV-1 assay is a real-time nucleic acid amplification assay available for HIV-1 viral load quantitation. The assay has a platform for automated extraction of viral RNA from plasma or dried blood spot samples, and an amplification platform with real time fluorescent detection. Overall, this study found no clinically relevant differences in viral load, if samples were extracted manually.

  18. Sensitivity and specificity of the GAMMACOAT-M CEA-RIA from Travenol-Genentech Diagnostics compared to the ABBOTT CEA-RIA monoclonal

    A new monoclonal radioimmunoassay from Travenol-Genentech Diagnostics was investigated with respect to its sensitivity and specificity and compared to the established monoclonal antibody assay of ABBOTT. Both tests revealed increased CEA plasma values in healthy smokers, whereby the elevation was dependent on the number of cigarettes smoked per day. The sensitivities as well as the cut-off levels for CEA at 90% specificity were coincident in both tests. (orig.)

  19. Serologic tracers (HBsAg and HBsAc) of hepatitis B virus in expectant mothers of the Perinatal Maternal Institute

    A study on hepatitis B tracers, (HBsAg and HBsAc), was conducted in women with different months of pregnancy at the Perinatal Maternal Institute in Lima, Peru. A total of 1010 mothers were studied during the period of January to October 1996, establishing by radioimmunoassay (RIA) whether they were positive or not. The results showed a prevalence rate of 1,6 for HBsAc and 1,3 for HBsAg for every 100,000 inhabitants. The incidence rate was 0,332 for HBsAc and 0,07 for HBsAg for every 100,000 inhabitants. This means that 21 expectant mothers are HBsAc positive and 5 are HBsAg positive. According to the investigations, there were different ways of transmission; promiscuity must be highlighted, as well as age -most of the mothers who were positive were between 20 and 25 years old- and origin. Most of them were immigrants from different places and live in shantytowns, which indicates that most of them have limited economic resources and have not received any orientation on family planning

  20. Serologic tracers (HBsAg and HBsAc) of hepatitis B virus in expectant mothers of the Perinatal Maternal Institute

    Garcia, B M

    1997-01-01

    A study on hepatitis B tracers, (HBsAg and HBsAc), was conducted in women with different months of pregnancy at the Perinatal Maternal Institute in Lima, Peru. A total of 1010 mothers were studied during the period of January to October 1996, establishing by radioimmunoassay (RIA) whether they were positive or not. The results showed a prevalence rate of 1,6 for HBsAc and 1,3 for HBsAg for every 100,000 inhabitants. The incidence rate was 0,332 for HBsAc and 0,07 for HBsAg for every 100,000 inhabitants. This means that 21 expectant mothers are HBsAc positive and 5 are HBsAg positive. According to the investigations, there were different ways of transmission; promiscuity must be highlighted, as well as age -most of the mothers who were positive were between 20 and 25 years old- and origin. Most of them were immigrants from different places and live in shantytowns, which indicates that most of them have limited economic resources and have not received any orientation on family planning.

  1. Dose-response characteristics of a monoclonal antibody based two-si immunoradiometric assay for hepatitis B surface antigen (HBsAg)

    Since the correlation between HBV infectivity and circulating HBsAG was established, increasingly sensitive tests for HBsAg have been developed. Of these, two-site immunoradiometric assays (2S-IRMA) employing polyclonal antibodies of diverse animal origins have proven to be the most sensitive. A number of 2S-IRMA based on mouse monoclonal antibodies have been developed and in 1983 one was released commercially by NML(R). The present study has compared the performance of this assay with that of the polyclonal antibody based HBsAg-assay, AUSRIA(R) II-125, and has looked particularly at dose responsiveness, sensitivity and specificity. The NML(R) monoclonal antibody based assay was found to have the capacity to detect HBsAg at concentrations of 0.31 ng/mL ad and 0.22 ng/mL ay respectively, whereas the polyclonal-based assay (AUSRIA(R) II-125) detected HBsAg as low as 0.09 ng/mL ad and 0.17 ng/mL ay. These findings are contrary to the expectations raised by the claim of significantly improved assay sensitivity with research prototype of the NML(R) assay published by the workers who developed the anti-HBs producing mouse hybridomas

  2. Peginterferon add-on results in more HBsAg decline compared to monotherapy in HBeAg-positive chronic hepatitis B patients.

    Brouwer, W P; Sonneveld, M J; Xie, Q; Guo, S; Zhang, N; Zeuzem, S; Tabak, F; Zhang, Q; Simon, K; Akarca, U S; Streinu-Cercel, A; Hansen, B E; Janssen, H L A

    2016-06-01

    It is unknown whether peginterferon (PEG-IFN) add-on to entecavir (ETV) leads to more HBsAg decline compared to PEG-IFN monotherapy or combination therapy, and whether ETV therapy may prevent HBsAg increase after PEG-IFN cessation. We performed a post hoc analysis of 396 HBeAg-positive patients treated for 72 weeks with ETV + 24 weeks PEG-IFN add-on from week 24 to 48 (add-on, n = 85), 72 weeks with ETV monotherapy (n = 90), 52 weeks with PEG-IFN monotherapy (n = 111) and 52 weeks PEG-IFN + lamivudine (combination, n = 110) within 2 randomized trials. HBsAg decline was assessed at the end of PEG-IFN (EOP) and 6 months after PEG-IFN (EOF) discontinuation. Differences in baseline characteristics were accounted for using inversed probability of treatment weights. At EOP, a HBsAg reduction of ≥1log10 IU/mL was more frequently achieved for patients in the add-on or combination therapy arms (both 36%), compared to PEG-IFN mono (20%) or ETV (8%) (add-on vs PEG-IFN mono P = 0.050). At EOF, the HBsAg reduction ≥1log10 IU/mL was only sustained in patients treated with ETV consolidation (add-on vs combination and PEG-IFN mono: 40% vs 23% and 18%, P = 0.029 and P = 0.003, respectively). For add-on, combination, PEG-IFN mono and ETV, the mean HBsAg-level change at EOF was -0.84, -0.81, -0.68 and -0.33 log10 IU/mL, respectively (P > 0.05 for PEG-IFN arms). HBeAg loss at EOF was 36%, 31%, 33% and 20%, respectively (P > 0.05). PEG-IFN add-on for 24 weeks results in more on-treatment HBsAg decline than does 52 weeks of PEG-IFN monotherapy. ETV therapy may maintain the HBsAg reduction achieved with PEG-IFN. PMID:26403919

  3. Study on the conditions for stabilizing trigonal-prism coordination compounds

    A new calculating method has been proposed for the elongation and twist of trigonal-prism. The calculations show that the calculated and determined values of the bite for bidentate trigonal prism complexes are similar and that rigidity of the bite favors the stabilization of the trigonal prism configuration. The structural characteristics of the bidentate ligands and central atoms are further discussed based on the structural data of trigonal-prism compounds. The discussion provides a guide for the preparation of new trigonal-prism labelled compounds

  4. Postural Stability Changes during Large Vertical Diplopia Induced by Prism Wear in Normal Subjects

    Matsuo,Toshihiko; Yamasaki,Hanako; Yasuhara,Hirotaka; Hasebe, Kayoko

    2013-01-01

    To test the effect of double vision on postural stability, we measured postural stability by electric stabilometry before prism-wearing and immediately, 15, 30, and 60min after continuous prism-wearing with 6 prism diopters in total (a 3-prism-diopter prism placed with the base up in front of one eye and with the base down in front of the other eye) in 20 normal adult individuals with their eyes open or closed. Changes in stabilometric parameters in the time course of 60min were analyzed stat...

  5. PREDICTION OF OUTCOME OF PAEDIATRIC PATIENTS BY VALIDATING PRISM III SCORING WITHIN 12 HOURS AND PRISM III AT 72-84 HOURS AFTER INITIATION OF THE TREATMENT

    Sonica

    2014-01-01

    `BACKGROUND: One of the scoring systems in Pediatric Intensive Care is the PRISM III (PAEDITRIC RISK OF MORTALITY III) which is an updated version of PRISM. Study was done at time point 72 hrs of initiation of therapy as well in a view that it will better prognosticate the outcome. AIMS: 1. To find out PRISM III within 1st 12 hours of admission and at 72-84 hours of admission, 2. To evaluate any correlation between PRISM III and mortality, 4.To find out correlation between...

  6. Transient safety performance of the PRISM innovative liquid metal reactor

    The PRISM sodium-cooled reactor concept utilizes passive safety characteristics and modularity to increase performance margins, improve licensability, reduce owner's risk and reduce costs. The relatively small size of each reactor module (471 MWt) facilitates the use of passive self-shutdown and shutdown heat removal features, which permit design simplification and reduction of safety-related systems. Key to the transient performance is the inherent negative reactivity feedback characteristics of the core design resulting from the use of metal (U-Pu-Zr) swing, and very low control rod runout worth. Selected beyond design basis events relying only on these core design features are analyzed and the design margins summarized to demonstrate the advancement in reactor safety achieved with the PRISM design concept

  7. Hyperbolic prisms and foams in Hele-Shaw cells

    The propagation of light in foams creates patterns which are generated due to the reflection and refraction of light. One of these patterns is observed by the formation of multiple mirror images inside liquid bridges in a layer of bubbles in a Hele-Shaw cell. We are presenting the existence of these patterns in foams and their relation with hyperbolic geometry and Sierpinski gaskets using the Poincare disk model. The images obtained from the experiment in foams are compared to the case of hyperbolic optical elements. -- Highlights: → The chaotic scattering of light in foams generating deltoid patterns is based on hyperbolic geometry. → The deltoid patterns are obtained through the Plateau borders in a Hele-Shaw cell. → The Plateau borders act like hyperbolic prism. → Some effects of the refraction and reflection of the light rays were studied using a hyperbolic prism.

  8. Extremely simple single-prism ultrashort- pulse compressor.

    Akturk, Selcuk; Gu, Xun; Kimmel, Mark; Trebino, Rick

    2006-10-16

    We have designed and demonstrated a very simple and compact ultrashort-pulse compressor using a single prism and a corner-cube. Our design is significantly easier to align and tune compared with previous designs. Angle-tuning the prism wavelength-tunes, and translating the corner cube varies the group-delay dispersion over a wide range. When tuned, the device automatically maintains zero angular dispersion, zero pulse-front tilt, zero spatial chirp, and unity magnification. The device can easily be built so that its output beam remains collinear with the input beam, and when the input beam or pulse compressor moves, the input and output beams remain collinear. PMID:19529405

  9. Enraizamento de estacas caulinares de kiwi (Actinidia chinensis Planch cv Abbott tratadas com auxinas e boro Rooting of kiwi stem cuttings (Actinidia chinensis Planch. cv Abbott treated with auxins and boron

    E.G. Ono

    1995-12-01

    Full Text Available O trabalho teve como finalidade, estudar o efeito de várias auxinas sintéticas em formulações comerciais e do boro, sobre o enraizamento de estacas caulinares de kiwi (Actinidia chinensis Planch, cv Abbott.. As estacas utilizadas continham dois nós e duas folhas cortadas ao meio, com aproximadamente 10 cm de comprimento, onde o corte basal em bisel foi realizado logo abaixo de um nó e o apical acima do outro nó. O efeito das auxinas, sobre o enraizamento de estacas caulinares de kiwi foi verificado mediante os seguintes tratamentos, aplicados sobre as bases das estacas: T1 H(20; T2 (NAA 300 ppm; T3 (IBA 300 ppm; T4 (NAA 300 ppm + B; T5 (IBA 300 ppm + B; T6 (NAA 0,5%-pó e T7 (IBA 0,5%-pó. Após o tratamento das estacas, estas foram plantadas em bandejas de enraizamento, contendo vermiculita pura e colocadas em câmara de nebulização, onde permaneceram por 120 dias, até a sua coleta. Para a avaliação do efeito de auxinas e do ácido bórico, sobre o enraizamento de estacas caulinares de kiwi, foram realizadas as seguintes observações: 1. porcentagem de estacas enraizadas; 2. análise de açúcares redutores e açúcares totais (em g/100 g de matéria seca; 3. análise de triptofano (em µg/100 mg de matéria seca. Os resultados obtidos no processo de enraizamento de estacas caulinares de kiwi (Actinidia chinensis Planch. variedade Abbott, levou a concluir que o inverno e outono foram as melhores épocas de coleta dos ramos de auxinas para a confecção das estacas. O processo de enraizamento foi ainda incrementado com a aplicação exógena na base das estacas, sendo que o alto teor de açúcares redutores e totais beneficiou a maior porcentagem de enraizamento.This study was carried out to evaluate the effects of some synthetical auxins and boron trade formulations in the rooting of stem cuttings of some kiwi (Actinidia chinensis Planch varieties. The experiment was carried out in a misty nebulization chamber in the Botany

  10. Prism-coupled light emission from tunnel junctions

    Ushioda, S.; Rutledge, J. E.; Pierce, R. M.

    1985-01-01

    Completely p-polarized light emission has been observed from smooth Al-AlO(x)-Au tunnel junctions placed on a prism coupler. The angle and polarization dependence demonstrate unambiguously that the emitted light is radiated by the fast-mode surface plasmon polariton. The emission spectra suggest that the dominant process for the excitation of the fast mode is through conversion of the slow mode to the fast mode mediated by residual roughness on the junction surface.

  11. Advanced SFR Concept Based on PRISM and KALIMER

    The Sodium-cooled Fast Reactor has been recognized as one of the promising nuclear options for generating electricity with efficient uranium resource utilization and reduction of radioactive wastes from nuclear power plants. This paper compares design features, identifies differences between KALIMER-600 and S-PRISM sodium-cooled reactors, and derives R and D requirements in order to explore the possibility of developing a novel SFR concept. (author)

  12. Prism adaptation does not alter configural processing of faces

    Bultitude, Janet H.; Downing, Paul E.; Robert D. Rafal

    2013-01-01

    Patients with hemispatial neglect (‘neglect’) following a brain lesion show difficulty responding or orienting to objects and events on the left side of space. Substantial evidence supports the use of a sensorimotor training technique called prism adaptation as a treatment for neglect. Reaching for visual targets viewed through prismatic lenses that induce a rightward shift in the visual image results in a leftward recalibration of reaching movements that is accompanied by a reduction of symp...

  13. Stereovision Imaging in Smart Mobile Phone Using Add on Prisms

    Bar-Magen Numhauser, Jonathan; Zalevsky, Zeev

    2014-03-01

    In this work we present the use of a prism-based add on component installed on top of a smart phone to achieve stereovision capabilities using iPhone mobile operating system. Through these components and the combination of the appropriate application programming interface and mathematical algorithms the obtained results will permit the analysis of possible enhancements for new uses to such system, in a variety of areas including medicine and communications.

  14. Prism therapy and visual rehabilitation in homonymous visual field loss.

    O'Neill, Evelyn C

    2011-02-01

    Homonymous visual field defects (HVFD) are common and frequently occur after cerebrovascular accidents. They significantly impair visual function and cause disability particularly with regard to visual exploration. The purpose of this study was to assess a novel interventional treatment of monocular prism therapy on visual functioning in patients with HVFD of varied etiology using vision targeted, health-related quality of life (QOL) questionnaires. Our secondary aim was to confirm monocular and binocular visual field expansion pre- and posttreatment.

  15. Prism therapy and visual rehabilitation in homonymous visual field loss.

    O'Neill, Evelyn C

    2012-02-01

    PURPOSE: Homonymous visual field defects (HVFD) are common and frequently occur after cerebrovascular accidents. They significantly impair visual function and cause disability particularly with regard to visual exploration. The purpose of this study was to assess a novel interventional treatment of monocular prism therapy on visual functioning in patients with HVFD of varied etiology using vision targeted, health-related quality of life (QOL) questionnaires. Our secondary aim was to confirm monocular and binocular visual field expansion pre- and posttreatment. METHODS: Twelve patients with acquired, documented HVFD were eligible to be included. All patients underwent specific vision-targeted, health-related QOL questionnaire and monocular and binocular Goldmann perimetry before commencing prism therapy. Patients were fitted with monocular prisms on the side of the HVFD with the base-in the direction of the field defect creating a peripheral optical exotropia and field expansion. After the treatment period, QOL questionnaires and perimetry were repeated. RESULTS: Twelve patients were included in the treatment group, 10 of whom were included in data analysis. Overall, there was significant improvement within multiple vision-related, QOL functioning parameters, specifically within the domains of general health (p < 0.01), general vision (p < 0.05), distance vision (p < 0.01), peripheral vision (p < 0.05), role difficulties (p < 0.05), dependency (p < 0.05), and social functioning (p < 0.05). Visual field expansion was shown when measured monocularly and binocularly during the study period in comparison with pretreatment baselines. CONCLUSIONS: Patients with HVFD demonstrate decreased QOL. Monocular sector prisms can improve the QOL and expand the visual field in these patients.

  16. Stereo Evaluation Of ALOS PRISM And IKONOS In Yemen

    Müller, Rupert; Schneider, Mathias; Radhadevi, P.V.; Reinartz, Peter; Schwonke, Friedhelm

    2009-01-01

    DLR's Remote Sensing Technology Institute has a long lasting experience in developing spaceborne stereo scanners (MEOSS, MOMS) and the corresponding photogrammetric software systems for stereo evaluation and orthorectification. It takes part in the ESA/JAXA-AO Program to evaluate the performance and potential of the three-line stereo scanner PRISM and the multispectral imaging sensor AVNIR-2 on-board the Japanese satellite ALOS as a principal investigator. The high geometric resolution of PRI...

  17. Performance analysis of the 840 MWt PRISM reference burner core

    The General Electric PRISM (Power Reactor, Innovative Small Module) is a modular, pool-type sodium-cooled fast reactor employing innovative, passive features to provide an extremely high level of public safety. A PRISM power block consists of two 840 MWt reactor modules, each with a vessel diameter of 9.15 m (30 ft), tied to a turbine generator and producing 622 MWe. A full-size plant consists of three power blocks producing 1866 MWe of electrical power. Two core configurations have been analyzed. The reference is a 'burner' core (conversion ratio of 0.8) and the alternative is a breakeven' core (plutonium consumption balanced by plutonium generation). The core nuclear designs are largely governed by passive safety and reactivity control issues. The key features employed to produce the desired passive safety characteristics are: a small core with a tight restraint system, the use of metallic U-Pu-Zr fuel, control rod withdrawal limiters (rod stops) and gas expansion modules (GEMs). A passive reactor vessel auxiliary cooling system (RVACS) assures safety-grade decay heat removal. This paper summarizes the operational and safety performance of the 840 MWt PRISM modular reactor, with emphasis on the reference burner core. (author)

  18. Controllable Sonar Lenses and Prisms Based on ERFs

    Bar-Cohen, Yoseph; Sherrit, Stewart; Chang, Zensheu; Bao, Xiaoqi; Paustian, Iris; Lopes, Joseph; Folds, Donald

    2004-01-01

    Sonar-beam-steering devices of the proposed type would contain no moving parts and would be considerably smaller and less power-hungry, relative to conventional multiple-beam sonar arrays. The proposed devices are under consideration for installation on future small autonomous underwater vehicles because the sizes and power demands of conventional multiple-beam arrays are excessive, and motors used in single-beam mechanically scanned systems are also not reliable. The proposed devices would include a variety of electrically controllable acoustic prisms, lenses, and prism/lens combinations both simple and compound. These devices would contain electrorheological fluids (ERFs) between electrodes. An ERF typically consists of dielectric particles floating in a dielectric fluid. When an electric field is applied to the fluid, the particles become grouped into fibrils aligned in rows, with a consequent increase in the viscosity of the fluid and a corresponding increase in the speed of sound in the fluid. The change in the speed of sound increases with an increase in the applied electric field. By thus varying the speed of sound, one varies the acoustic index of refraction, analogously to varying the index of refraction of an optical lens or prism. In the proposed acoustic devices, this effect would be exploited to control the angles of refraction of acoustic beams, thereby steering the beams and, in the case of lenses, controlling focal lengths.

  19. Stabilization of a self-referenced, prism-based, Cr:forsterite laser frequency comb using an intracavity prism

    The frequency comb from a prism-based Cr:forsterite laser has been frequency stabilized using intracavity prism insertion and pump power modulation. Absolute frequency measurements of a CW fiber laser stabilized to the P(13) transition of acetylene demonstrate a fractional instability of ∼2x10-11 at a 1 s gate time, limited by a commercial Global Positioning System (GPS)-disciplined rubidium oscillator. Additionally, absolute frequency measurements made simultaneously using a second frequency comb indicate relative instabilities of 3x10-12 for both combs for a 1 s gate time. Estimations of the carrier-envelope offset frequency linewidth based on relative intensity noise and the response dynamics of the carrier-envelope offset to pump power changes confirm the observed linewidths.

  20. Prism: a new approach to radiotherapy planning software

    Purpose: We describe the capabilities and performance of Prism, an innovative new radiotherapy planning system with unusual features and design. The design and implementation strategies are intended to assure high quality and clinical acceptability. The features include Artificial Intelligence tools and special support for multileaf collimator (MLC) systems. The design provides unusual flexibility of operation and ease of expansion. Methods and Materials: We have implemented Prism, a three-dimensional (3D) radiotherapy treatment-planning system on standard commercial workstations with the widely available X window system. The design and implementation use ideas taken from recent software engineering research, for example, the use of behavioral entity-relationship modeling and the 'Mediator Method' instead of ad-hoc programming. The Prism system includes the usual features of a 3D planning system, including Beam's Eye View and the ability to simulate any treatment geometry possible with any standard radiotherapy accelerator. It includes a rule-based expert system for automated generation of the planning target volume as defined in ICRU Report 50. In addition, it provides special support for planning treatments with a multileaf collimator (MLC). We also implemented a Radiotherapy Treatment Planning Tools Foundation for Prism, so that we are able to use software tools from other institutions without any source code modification. Results: The Prism system has been in clinical operation at the University of Washington since July 1994 and has been installed at several other clinics. The system is run simultaneously by several users, each with their own workstation operating from a common networked database and software. In addition to the dosimetrists, the system is used by radiation oncologists to define tumor and target volumes and by radiation therapists to select treatment setups to load into a computer controlled accelerator. Conclusions: Experience with the

  1. Local Seismicity Recorded by ChilePEPPER: Implications for Dynamic Accretionary Prism Response and Long-term Prism Evolution

    de Moor, A.; Trehu, A. M.; Tryon, M. D.

    2015-12-01

    To investigate the dynamic response of the outer accretionary wedge updip from the patch of greatest slip during the Mw8.8 2010 Maule earthquake, 10 Ocean Bottom Seismometers (OBS) were deployed from May 2012 to March 2013 in a small array with an inter-instrument spacing of ~12 km . Nine instruments were recovered, with 4 recording data on 3 intermediate-band 3-component seismometers and a differential pressure gauge and 5 recording data from absolute pressure gauges. [note: All instruments were also equipped with a fluid flow meter sensitive to flow rates as low as 0.0001 cm/yr in or out of the sediments. However, no flow signal was detected.] Here we present hypocenters for 569 local events that have S-P times less than 17 seconds (i.e. within ~125 km of the array) using hand-picked arrival times and a 1D velocity model derived from a 2D seismic refraction profile through the region (Moscoso et al 2011, EPSL). We analyze the distribution of seismicity in the context of published slip models, ChilePEPPER high-resolution seismic reflection data, critical taper analysis done by Cubas et al 2013 (EPSL), and offshore gravity data. The data show distinct segmentation within the outer prism. The northern section of the study area is characterized by a lack of seismicity, accretion of nearly all incoming sediment and a prism at critical taper. In contrast, abundant seismicity, significant sediment underthrusting at the deformation front and a prism below critical taper angle characterize the southern part of the study area. Both coseismic slip and post-rupture local seismicity can be related to density anomalies within the upper plate as revealed by free air gravity data corrected for the effects of bathymetry and the subducting plate. [ChilePEPPER - Project Evaluating Prism Post-Earthquake Response

  2. Survey of both hepatitis B virus (HBsAg and hepatitis C virus (HCV-Ab coinfection among HIV positive patients

    Pournia Yadollah

    2009-11-01

    Full Text Available Abstract Background HIV, HBVand HCV is major public health concerns. Because of shared routes of transmission, HIV-HCV coinfection and HIV-HBV coinfection are common. HIV-positive individuals are at risk of coinfection with HBV and HCV infections. The prevalence rates of coinfection with HBV and HCV in HIV-patients have been variable worldwide depending on the geographic regions, and the type of exposure. Aim This study aimed to examine HBV and HCV coinfection serologically and determine the shared and significant factors in the coinfection of HIV-positive patients. Methods This descriptive, cross-sectional study was carried out on 391 HIV-positive patients including 358 males and 33 females in Lorestan province, west Iran, to survey coinfection with HBsAg and anti-HCV. The retrospective demographic data of the subjects was collected and the patients' serums were analyzed by ELISA kits including HBsAg and anti-HCV. The collected data was analyzed with SPSS software (15 and Chi-square. Fisher's exact test with 5% error intervals was used to measure the correlation of variables and infection rates. Results The results of the study indicated that the prevalence of coinfection in HIV-positive patients with hepatitis viruses was 94.4% (370 in 391, out of whom 57 (14.5% cases were HBsAg positive, 282 (72% cases were anti-HCV positive, and 31 (7.9% cases were both HBsAg and anti-HCV positive. Conclusion There was a significant correlation between coinfection with HCV and HBV and/or both among HIV-positive patients depending on different variables including sex, age, occupation, marital status, exposure to risk factors.(p

  3. Experimental study on the flow regimes past a confined prism undergoing self-sustained oscillations

    Highlights: • A experimental study is presented on the flow regimes past a confined prism. • Flow is 3D and involves the self-sustained motion of the prism. • Different regimes are indentified as a function of two control parameters. • Control parameters are the Reynolds number and the density ratio. • The concept has potential industrial applications. - Abstract: An experimental study based on Particle Image Velocimetry (PIV) is presented with the objective of studying the flow regimes that appear in the flow past a confined prism undergoing self-sustained oscillations at low Reynolds numbers (Re). The square-section prism, placed inside a 3D square cross-section vertical channel with a confinement ratio of 1/2.5, was tethered to the channel walls and, therefore, it was allowed to move freely transverse to the incoming flow. Re (based on the prism cross-section height) was varied in the range from 100 to 700. Three different prism to fluid density ratios (m∗) were considered: 0.56, 0.70, and 0.91. These two parameters, Re and m∗, were used to map the results obtained. In particular, it was found that five different regimes appear: (1) steady prism with steady recirculation bubble, (2) steady prism with unsteady vortex shedding wake, (3) large amplitude low frequency oscillating prism with unsteady vortex shedding wake, (4) small amplitude high frequency oscillating prism with unsteady vortex shedding wake, and (5) irregular/chaotic motion of both the prism and the wake. The PIV results and associated numerical simulations were used to analyze the different prism and wake states

  4. Redshift estimation from low-resolution prism SEDs with an NGST MOS

    Teplitz, Harry I.; Malumuth, Eliot; Woodgate, Bruce E.; Moseley, S. Harvey; Gardner, Jonathan P.; Kimble, Randy A.; Bowers, Charles W.; Kutyrev, Alexander S.; Fettig, Rainer K.; Wesenberg, Richard P.; Mentzell, John E.

    2000-01-01

    We discuss the utility of a low resolution prism as a component of a Multi-Object Spectrometer for NASA's proposed Next Generation Space Telescope (NGST). Low resolution prism spectroscopy permits simultaneous observation of the 0.6-5micron wavelength regime at R~50. To such data we can apply the modern techniques in spectral energy distribution (SED) fitting to determine source redshifts, sometimes called ``photometric redshifts''. Low resolution prism observations of galaxy SED's provide a ...

  5. Synthesis and Photocatalytic Activity of Ag3PO4 Triangular Prism

    Pengyu Dong; Yan Hao; Peiyang Gao; Entian Cui; Qinfang Zhang

    2015-01-01

    Ag3PO4 triangular prism was synthesized by a facile chemical precipitation approach by simply adjusting external ultrasonic condition. The as-synthesized Ag3PO4 triangular prism was characterized by X-ray diffraction pattern (XRD), field emission scanning electron microscopy (SEM), fourier transform infrared (FTIR) spectra, and ultraviolet-visible diffuse reflectance (UV-vis DRS) absorption spectra. The photocatalytic activity of Ag3PO4 triangular prism was evaluated by photodegradation of or...

  6. PriSM: a primer selection and matching tool for amplification and sequencing of viral genomes

    Yu, Qing; Ryan, Elizabeth M; Allen, Todd M.; Birren, Bruce W.; Henn, Matthew R.; Lennon, Niall J.

    2010-01-01

    Summary: PriSM is a set of algorithms designed to select and match degenerate primer pairs for the amplification of viral genomes. The design of panels of hundreds of primer pairs takes just hours using this program, compared with days using a manual approach. PriSM allows for rapid in silico optimization of primers for downstream applications such as sequencing. As a validation, PriSM was used to create an amplification primer panel for human immunodeficiency virus (HIV) Clade B.

  7. Left-Deviating Prism Adaptation in Left Neglect Patient: Reflexions on a Negative Result

    Jacques Luauté; Sophie Jacquin-Courtois; Jacinta O'Shea; Laure Christophe; Gilles Rode; Dominique Boisson; Yves Rossetti

    2012-01-01

    Adaptation to right-deviating prisms is a promising intervention for the rehabilitation of patients with left spatial neglect. In order to test the lateral specificity of prism adaptation on left neglect, the present study evaluated the effect of left-deviating prism on straight-ahead pointing movements and on several classical neuropsychological tests in a group of five right brain-damaged patients with left spatial neglect. A group of healthy subjects was also included for comparison purpos...

  8. Mortality Risk Prediction by Application of PRISM Scoring System in Pediatric Intensive Care Unit

    Mahdi Mohammadi; Afshin Fayyazi; Mohsen Raeisi; Noor Mohammad Noori; Ali Khajeh; Ghasem Miri-Aliabad

    2013-01-01

    Objective: The Pediatric Risk of Mortality (PRISM) score is one of the scores used by many pediatricians for prediction of the mortality risk in the pediatric intensive care unit (PICU). Herein, evaluate the efficacy of PRISM score in prediction of mortality rate in PICU.Methods: In this cohort study, 221 children admitted during an 18-month period to PICU, were enrolled. PRISM score and mortality risk were calculated. Follow up was noted as death or discharge. Results were analyzed by Kaplan...

  9. DYNAMIQUE DES PRISMES OROGÉNIQUES, LE RÔLE DES FLUIDES

    Deville, Eric

    2011-01-01

    The work presented is a dossier presented to anobyainaccreditation to supervise research (HDR). It concerns the role of fluids in orogenic prisms. The presentation is organized around three approaches: (1) an integrated approach to iconic sites: a mature accretionary prism (the prism of Barbados) and a chain collision (Western Alps), (2) a methodological approach, and (3) a thematic approach to study processes poorly understood and to discuss problems of structure and dynamics of convergent o...

  10. Universal screening for hepatitis B among pregnant women led to 96% vaccination coverage among newborns of HBsAg positive mothers in Denmark

    Harder, Katja Majlund; Cowan, Susan; Eriksen, Mette Brandt; Krarup, Henrik B; Christensen, Peer Brehm

    2011-01-01

    In Denmark selective screening programs of pregnant women for hepatitis B missed 30-50% of high-risk groups and in late 2005 a universal screening of pregnant women for HBsAg was implemented. During a 2-year period a prospective enhanced surveillance of the universal screening was performed to...... and households of HBsAg positive pregnant women were assembled. Among 140,376 HBsAg tests of pregnant women, 371 (0.26%) were positive. The prevalence among women of Danish origin was 0.012% and 2.74% among foreign born women, highest for women from Southeast Asia (14.5%). Genotype C was the most...... of passive follow-up two transmissions (0.5%) have been notified. Among children born of the positive mothers prior to the trial-period 7.3% had been notified. Thus the prevalence of HBV positive mothers has more than doubled in Denmark over the last 40 years, but among women of Danish origin it has...

  11. Mutations in the S gene and in the overlapping reverse transcriptase region in chronic hepatitis B Chinese patients with coexistence of HBsAg and anti-HBs

    Feng Ding

    2016-02-01

    Full Text Available Abstract Background The mechanism underlying the coexistence of hepatitis B surface antigen and antibodies to HBsAg in chronic hepatitis B patients remains unknown. Aims This research aimed to determine the clinical and virological features of the rare pattern. Methods A total of 32 chronic hepatitis B patients infected by HBV genotype C were included: 15 carrying both HBsAg and anti-HBs (group I and 17 solely positive for HBsAg (group II. S gene and reverse transcriptase region sequences were amplified, sequenced and compared with the reference sequences. Results The amino acid variability within major hydrophilic region, especially the “a” determinant region, and within reverse transcriptase for regions overlapping the major hydrophilic region in group I is significantly higher than those in group II. Mutation sI126S/T within the “a” determinant was the most frequent change, and only patients from group I had the sQ129R, sG130N, sF134I, sG145R amino acid changes, which are known to alter immunogenicity. Conclusions In chronic patients, the concurrent HBsAg/anti-HBs serological profile is associated with an increased aa variability in several key areas of HBV genome. Additional research on these genetic mutants are needed to clarify their biological significance for viral persistence.

  12. Erythropoiesis: Short Report: Translation of Analysis Results between Serum Ferritin Assays, Ferritin RIA AmershamTM and Abbott AxSYMTM Ferritin.

    Milman, NILS; Byg, KELD-ERIK; Juul-Jørgensen, BIRGIT; Weis Bentzon, MICHAEL

    1999-01-01

    The serum ferritin assays, Ferritin RIA Amersham(TM) and Abbott AxSYM(TM) Ferritin were compared in order to translate values from one assay to the other. Serum ferritin was analysed with both assays in 102 samples. Logarithmic transformation of the results was performed in order to stabilize the variance. The relationship between the untransformed values was most exactly expressed by a proportionality: AxSYM Ferritin = 0.873 * RIA Ferritin. Due to this proportionality, the numerical difference between the assays increases with the ferritin concentration, although the percentage difference between the assays remains constant. PMID:11399562

  13. BC-5500与Abbott CD-3700全自动血细胞分析仪性能的比较分析

    吴立兵; 李德奎

    2010-01-01

    @@ 深圳迈瑞公司和美国雅培公司采用不同的检测原理分别生产了BC-5500和Abbott CD-3700血细胞分析仪,为了解这2种血细胞分析仪检测结果的准确性、精密度和一致性,本组对二者的临床检测结果进行了分析、比较.结果报告如下.

  14. Development and Clinical Evaluation of a Recombinant-Antigen-Based Cytomegalovirus Immunoglobulin M Automated Immunoassay Using the Abbott AxSYM Analyzer

    Maine, G T; Stricker, R; Schuler, M.; Spesard, J.; Brojanac, S.; Iriarte, B.; Herwig, K.; Gramins, T.; Combs, B.; Wise, J.; Simmons, H.; Gram, T.; Lonze, J.; Ruzicki, D.; Byrne, B

    2000-01-01

    A new microparticle enzyme immunoassay (MEIA), the Cytomegalovirus (CMV) Immunoglobulin M (IgM) test, was developed on the Abbott AxSYM analyzer. This test uses recombinant CMV antigens derived from portions of four structural and nonstructural proteins of CMV: pUL32 (pp150), pUL44 (pp52), pUL83 (pp65), and pUL80a (pp38). A total of 1,608 specimens from random volunteer blood donors (n = 300), pregnant women (n = 1,118), transplant recipients (n = 6), and patients with various clinical condit...

  15. Group-delay Dispersion in Double-prism Pair and Limitation in Broadband Laser Pulses

    程昭; 赵卫

    2002-01-01

    A general expression of group-delay dispersion is obtained without any approximation for a pair of double prisms with an arbitrary apex angle. This expression also includes the change of dispersion resulting from change in insertion of the prism material into the beam by translating prism-pairs. The high-order dispersion can be calculated by means of this expression. The limitation for generation of negative group-delay dispersion by use of prism-pairs is presented for ultrashort laser pulses with broadband spectrum.

  16. Ray-optical negative refraction and pseudoscopic imaging with Dove-prism arrays

    Courtial, J.; Nelson, J

    2008-01-01

    A sheet consisting of an array of small, aligned Dove prisms can locally (on the scale of the width of the prisms) invert one component of the ray direction. A sandwich of two such Dove-prism sheets that inverts both transverse components of the ray direction is a ray-optical approximation to the interface between two media with refractive indices +n and –n. We demonstrate the simulated imaging properties of such a Dove-prism-sheet sandwich, including a demonstration of pseudoscopic imaging.

  17. PRISM -- A tool for modelling proton energy deposition in semiconductor materials

    This paper presents a description of, and test results from, a new PC based software simulation tool PRISM (Protons in Semiconductor Materials). The model describes proton energy deposition in complex 3D sensitive volumes of semiconductor materials. PRISM is suitable for simulating energy deposition in surface-barrier detectors and semiconductor memory devices, the latter being susceptible to Single-Event Upset (SEU) and Multiple-Bit Upset (MBU). The design methodology on which PRISM is based, together with the techniques used to simulate ion transport and energy deposition, are described. Preliminary test results used to analyze the PRISM model are presented

  18. A high throughput (>90%), large compensation range, single-prism femtosecond pulse compressor

    Kong, Lingjie

    2013-01-01

    We demonstrate a high throughput, large compensation range, single-prism femtosecond pulse compressor, using a single prism and two roof mirrors. The compressor has zero angular dispersion, zero spatial dispersion, zero pulse-front tilt, and unity magnification. The high efficiency is achieved by adopting two roof mirrors as the retroreflectors. We experimentally achieved ~ -14500 fs2 group delay dispersion (GDD) with 30 cm of prism tip-roof mirror prism separation, and ~90.7% system throughput with the current implementation. With better components, the throughput can be even higher.

  19. The spectral characteristics of the splitting angle for double Wollaston prism

    WU Wen-di; WANG Zhao-bing; WANG Hai-long; ZHANG Shan

    2009-01-01

    The spectral characteristics of the splitting angle and its asymmetry for double-Wollaston prism are analyzed theoretically. With the increase of the prism structure angle, the splitting angle of the double Wollaston prism and its asymmetry increase. However, the splitting angle decreases with the increase of the wavelength of incident light. The influence of the incident light wavelength on the splitting angle in the ultraviolet wave band is much greater than that in visible and near-infrared wave band. To verify the theoretical analysis, the characteristics of the double Wollaston prism are also studied experimentally.

  20. Ultrafine Metal-Organic Right Square Prism Shaped Nanowires.

    Otake, Ken-Ichi; Otsubo, Kazuya; Sugimoto, Kunihisa; Fujiwara, Akihiko; Kitagawa, Hiroshi

    2016-05-23

    We report the structural design and control of electronic states of a new series of ultrafine metal-organic right square prism-shaped nanowires. These nanowires have a very small inner diameter of about 2.0 Å, which is larger than hydrogen and similar to xenon atomic diameters. The electronic states of nanowires can be widely controlled by substitution of structural components. Moreover, the platinum homometallic nanowire shows a 100 times higher proton conductivity than a palladium/platinum heterometallic one depending on the electronic states. PMID:27080935

  1. Detection of S-gene 'a' determinant variants in hepatitis B patients with both positive HBsAg and HBsAb markers

    Objective: To explore the S-gene 'a' determinant variants in hepatitis B patients with both positive HBsAg and HBsAb markers and the effect on the antigenicity of HBsAg. Methods: Quantitative determination of HBV - DNA with competent PCR microfluidic chit method was performed in eight sera specimens from seven hepatitis B patients with both positive HBsAg and HBsAb markers. HBV S-gene was amplified with nested PCR, the PCR product was directly examined for any sequence variant of the amino acids. HBV markers were tested with the very sensitive ELISA/MEIA method in these seven patients. The above rests were also performed in 15 children after failed immunization with hepatitis B vaccine and 9 recipients of liver transplantation for terminal hepatitis B treated with HBIG and lamivudine, serving as controls. Results: The HBsAb contents in the seven patients were all below 80 mIu/ml. Two of the patients with positive HBV-DNA showed no 'a' determinant variant. Two of the four HBV-DNA negative patients demonstrated amino-acid variants (126, 131). One patients who was originally HBV-DNA positive but later turned negative after treatment with interferon and lamivudine demonstrated variant (126). In the 9 patients after successful liver transplantation, the HBsAb contents were all about 150mIu/ml with negative HBV-DNA and no variant. In the 15 immunization failures, HBV-DNA was positive in 14 of them, with 2 cases of variant at 145, 1 case at 126 and 1 case at 134. Conclusion: In some patients with chronic B hepatitis with both positive HBsAg and HBsAb markers, as well as in some vaccine immunization failures, there were 'a' determinant variants, which might alter the antigenicity of HBsAg with escape from the neutralization of low HBsAb. The 'a' determinant variant might also affect the replication of the virus. In this study, no variant was shown in patients after successful liver transplantation. However, the number of patients was too small and the result was of no

  2. Serum concentration of sFas and sFasL in healthy HBsAg carriers, chronic viral hepatitis B and C patients

    Tadeusz Wojciech Lapinski; Oksana Kowalczuk; Danuta Prokopowicz; Lech Chyczewski

    2004-01-01

    AIM: To estimate the amount of apoptosis among healthy HBsAg carriers, patients with chronic HBV infection treated with lamk udine and patients with chronic HCV infection treated with interferon alpha and ribavirin. Activity of apoptosis was evaluated by serum sFas/sFasL concentration measurement.Moreover dependence between apoptosis and HBV-DNA or HCV-RNA levels was studied.METHODS: Eighty-six persons were included into study: 34healthy HBsAg carriers, 33 patients with chronic HBV infection and 19 patients with chronic HCV infection. Serum levels of sFas/sFasL were measured by ELISA assay. HBV-DNA and HCV-RNA were measured by RT-PCR assay. Levels of sFas/sFasL were determined before and 2 and 12 wk after therapy in patients with chronic hepatitis B and C infection.HBV-DNA or HCV-RNA was detected before treatment and 6 mo after treatment.RESULTS: Twenty-four (71%) healthy HBsAg carriers showed HBV-DNA over 105/mL, which was comparable to the patients with chronic hepatitis B. Independently from HBV-DNA levels,the concentration of sFas among healthy HBsAg carriers was comparable to healthy persons. Among patients with chronic hepatitis B and C, the concentration of sFas was significantly higher in comparison to healthy HBsAg carriers and healthy persons. In chronic hepatitis B patients the concentration of sFas was decreased during lamivudine treatment. Among chronic hepatitis C patients the concentration of sFas was increased during IFN alpha and ribavirin treatment. sFasL was not detected in control group. Furthermore sFasL occurred more frequently in chronic hepatitis C patients in comparison to chronic hepatitis B patients.CONCLUSION: There are no correlations between apoptosis and HBV-DNA levels. However ther is an association between apoptosis and activity of inflammation in patients with chronic HBV infection. Apoptosis can be increased in patients with chronic hepatitis C by effective treatment which may be a result of apoptosis stimulation by IFN-α.

  3. Design and expression of fusion protein consists of HBsAg and Polyepitope of HCV as an HCV potential vaccine

    Gholizadeh, Monireh; Khanahmad, Hossein; Memarnejadian, Arash; Aghasadeghi, Mohammad Reza; Roohvand, Farzin; Sadat, Seyed Mehdi; Cohan, Reza Ahangari; Nazemi, Ali; Motevalli, Fatemeh; Asgary, Vahid; Arezumand, Roghaye

    2015-01-01

    Background: Hepatitis C virus (HCV) infection is a serious public health threat worldwide. Cellular immune responses, especially cytotoxic T-lymphocytes (CTLs), play a critical role in immune response toward the HCV clearance. Since polytope vaccines have the ability to stimulate the cellular immunity, a recombinant fusion protein was developed in this study. Materials and Methods: The designed fusion protein is composed of hepatitis B surface antigen (HBsAg), as an immunocarrier, fused to an HCV polytope sequence. The polytope containing five immunogenic epitopes of HCV was designed to induce specific CTL responses. The construct was cloned into the pET-28a, and its expression was investigated in BL21 (DE3), BL21 pLysS, BL21 pLysE, and BL21 AI Escherichia coli strains using 12% gel sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Finally, the identity of expressed fusion protein was confirmed by Western blotting using anti-His monoclonal antibody and affinity chromatography was applied to purify the expressed protein. Results: The accuracy of the construct was confirmed by restriction map analysis and sequencing. The transformation of the construct into the BL21 (DE3), pLysS, and pLysE E. coli strains did not lead to any expression. The fusion protein was found to be toxic for E. coli DE3. By applying two steps inhibition, the fusion protein was successfully expressed in BL21 (AI) E. coli strain. Conclusion: The HBsAg-polytope fusion protein expressed in this study can be further evaluated for its immunogenicity in animal models. PMID:26682209

  4. Deformation of the Nankai Trough inner accretionary prism: The role of inherited structures

    Boston, Brian; Moore, Gregory F.; Jurado, María. José; Sone, Hiroki

    2016-02-01

    Accretionary prisms commonly grow seaward, with the strata of the inner prism consisting of older, previously accreted outer prism rocks overlain by thick fore-arc basin strata. We focus on the Nankai Trough inner accretionary prism using three-dimensional (3-D) seismic data and logging data from the Integrated Ocean Drilling Program (IODP). We update the 3-D seismic volume using well velocity data to better constrain deeper horizons. Interpretation of these horizons reveals multiple folds with axial surfaces that strike near parallel to modern outer prism thrust faults, and we interpret that these folds formed as a result of thrust faulting. Reactivation of one inner prism thrust fault continued until at least ˜0.44 Ma, after the modern fore-arc basin formed, indicating that the inner prism had continued deformation until that time. Structural restorations of these folded seismic horizons demonstrate that ˜580 m of slip occurred on this steeply dipping reactivated thrust after fore-arc basin formation. Structural interpretation and analysis of logging-while-drilling data, including borehole images, in the deep inner prism revealed intense deformation of a generally homogenous lithology characterized by bedding that dips steeply (60°-90°), intersected by faults and fractures that have a range of dips and densities. Our study of the deep Kumano Basin provides new insights into the structure of the inner prism and reveals that although the inner prism has partially preserved inherited outer prism structures, these older folds and faults are steeply rotated and cut by multiple fracture populations during subsequent deformation.

  5. Comparison of the AdvanSure Human Papillomavirus Screening Real-Time PCR, the Abbott RealTime High Risk Human Papillomavirus Test, and the Hybrid Capture Human Papillomavirus DNA Test for the Detection of Human Papillomavirus

    Hwang, Yusun; Lee, Miae

    2012-01-01

    Background We evaluated the performance of various commercial assays for the molecular detection of human papillomavirus (HPV); the recently developed AdvanSure HPV Screening real-time PCR assay (AdvanSure PCR) and the Abbott RealTime High Risk HPV PCR assay (Abbott PCR) were compared with the Hybrid Capture 2 HPV DNA Test (HC2). Methods All 3 tests were performed on 177 samples, and any sample that showed a discrepancy in any of the 3 tests was genotyped using INNO-LiPA HPV genotyping and/or...

  6. 全自动血液分析仪Sysmex XE-2100与Abbott CD-3700的比较分析

    范华杰; 凌励; 周道银

    2006-01-01

    目的比较分析Sysmex XE-2100和Abbott CD-3700 2类全自动血液分析仪各项检测参数结果的精确度和相关性.方法选取EDTA-K2抗凝静脉全血,对2台仪器进行精密度和相关性的检测.结果精密度测定,Sysmex XE-2100血细胞计数各参数变异系数(CV)值位于0.24%~3.56%之间,白细胞分类各参数CV值位于0.66%~37.04%之间;Abbott CD-3700血细胞计数各参数CV值位于0.30%~4.37%之间,白细胞分类各参数CV值位于0.92%~27.91%之间.2台仪器间血细胞计数各参数相关系数的平方(r2)位于0.931 2~0.998 7之间.结论 2台仪器各参数精密度符合设计范围,两者之间相关性较好.

  7. The PRISM (Pliocene palaeoclimate) reconstruction: time for a paradigm shift.

    Dowsett, Harry J; Robinson, Marci M; Stoll, Danielle K; Foley, Kevin M; Johnson, Andrew L A; Williams, Mark; Riesselman, Christina R

    2013-10-28

    Global palaeoclimate reconstructions have been invaluable to our understanding of the causes and effects of climate change, but single-temperature representations of the oceanic mixed layer for data-model comparisons are outdated, and the time for a paradigm shift in marine palaeoclimate reconstruction is overdue. The new paradigm in marine palaeoclimate reconstruction stems the loss of valuable climate information and instead presents a holistic and nuanced interpretation of multi-dimensional oceanographic processes and responses. A wealth of environmental information is hidden within the US Geological Survey's Pliocene Research, Interpretation and Synoptic Mapping (PRISM) marine palaeoclimate reconstruction, and we introduce here a plan to incorporate all valuable climate data into the next generation of PRISM products. Beyond the global approach and focus, we plan to incorporate regional climate dynamics with emphasis on processes, integrating multiple environmental proxies wherever available in order to better characterize the mixed layer, and developing a finer time slice within the Mid-Piacenzian Age of the Pliocene, complemented by underused proxies that offer snapshots into environmental conditions. The result will be a proxy-rich, temporally nested, process-oriented approach in a digital format-a relational database with geographic information system capabilities comprising a three-dimensional grid representing the surface layer, with a plethora of data in each cell. PMID:24043866

  8. The PRISM (Pliocene Palaeoclimate) reconstruction: Time for a paradigm shift

    Dowsett, Harry J.; Robinson, Marci M.; Stoll, Danielle K.; Foley, Kevin M.; Johnson, Andrew L. A.; Williams, Mark; Riesselman, Christina

    2013-01-01

    Global palaeoclimate reconstructions have been invaluable to our understanding of the causes and effects of climate change, but single-temperature representations of the oceanic mixed layer for data–model comparisons are outdated, and the time for a paradigm shift in marine palaeoclimate reconstruction is overdue. The new paradigm in marine palaeoclimate reconstruction stems the loss of valuable climate information and instead presents a holistic and nuanced interpretation of multi-dimensional oceanographic processes and responses. A wealth of environmental information is hidden within the US Geological Survey's Pliocene Research,Interpretation and Synoptic Mapping (PRISM) marine palaeoclimate reconstruction, and we introduce here a plan to incorporate all valuable climate data into the next generation of PRISM products. Beyond the global approach and focus, we plan to incorporate regional climate dynamics with emphasis on processes, integrating multiple environmental proxies wherever available in order to better characterize the mixed layer, and developing a finer time slice within the Mid-Piacenzian Age of the Pliocene, complemented by underused proxies that offer snapshots into environmental conditions. The result will be a proxy-rich, temporally nested, process-oriented approach in a digital format—a relational database with geographic information system capabilities comprising a three-dimensional grid representing the surface layer, with a plethora of data in each cell.

  9. The Color Splitting System for TV Cameras - XYZ Prism

    E. Kostal

    2001-09-01

    Full Text Available One of the dominant aspects, which prejudices the quality of colorimage reproduction, is the first operation in TV chain - scanning. Upto this day, the color splitting system, working in RGB colorimetricsystem, is still entirely used. The existence of negative parts of thecolor matching functions r(l, g(l, b(l causes complications byoptical separation of partial pictures R, G, B in classic scanningsystem. It leads to distortion of reproduction of color images.However, the specific technical and scientific applications, where thecolor carries the substantial part of information (cosmic development,medicine, demand high fidelity of color reproduction. This articlesubmits the results of the design of the color splitting system workingin XYZ colorimetric system (next only XYZ prism. Shortly the way toobtain theoretical spectral reflectances of partial filters of XYZprism is described. Further, these filters are approximated by realoptical interference filters and the geometry of XYZ prism isestablished. Finally, the results of the colorimetric distortion testof proposed scanning system are stated.

  10. ABBOTTARCHITECTC16000全自动生化分析仪性能评价%Evaluation on performance of ABBOTT ARCHITECT C16000 automatic biochemistry analyzer

    张娟; 蒋小燕; 李顺君; 黄文芳

    2014-01-01

    Objective To evaluate the main performance of ABBOTT ARCHITECT C160000 biochemistry analyzer,and to judge whether the performance meets the laboratory requirement.Methods According to the clinical laboratory management meth-od and the requirement of accreditation of national laboratory,the precision,accuracy and linearity of the 17 test items(Urea,Cre, UA,Glu,etc.)were analyzed by the CLSI EP5-A2 document,CLSI EP9-A2 document and CLSI EP6-P document;the quotative ref-erence ranges of the 17 test items were verified.Results The coefficient of variation(CV)in within-batch precision of Urea,Cre, UA,Glu,etc.was ≤1/4 CLIA′88 standard and CV in the between-batch precision ≤1/3CLIA′88 standard;in the accuracy test,the relative bias of the 17 test items≤1/2CLIA′88 standard;the linearity of the 17 items was good(r2 >0.95);the cited reference range of various detection items was suitable.Conclusion The performance of the ABBOTT ARCHITECT C160000 automatic biochem-istry analyzer meets the laboratory demand.%目的:对 ABBOTT ARCHITECT C16000生化分析仪主要性能进行评价,判断其是否能够满足本科实验室需求。方法依照实验室管理办法及国家实验室认可的要求,分别采用美国临床和实验室标准化协会(CLSI)的 EP5-A2、EP9-A2和EP6-A 文件评价方法分析尿素(Urea)、肌酐(Cre)、尿酸(UA)和葡萄糖(Glu)等17项检测项目的精密度、准确度和线性;并对各检测项目引用的参考区间进行验证。结果 ABBOTT ARCHITECT C16000生化分析仪 Urea、Cre、UA、Glu 等17项检测项目批内精密度变异系数(CV)均小于或等1/4CLIA′88标准,批间精密度 CV 均小于或等于1/3CLIA′88标准;在准确度试验中,该17项检测项目的相对偏倚均小于或等于1/2CLIA′88标准;线性良好(r2>0.95);各检测项目引用的参考区间合适。结论 ABBOTT ARCHITECT C16000生化分析仪性能满足本实验室需求。

  11. Prism Foil from an LCD Monitor as a Tool for Teaching Introductory Optics

    Planinsic, Gorazd; Gojkosek, Mihael

    2011-01-01

    Transparent prism foil is part of a backlight system in LCD monitors that are widely used today. This paper describes the optical properties of the prism foil and several pedagogical applications suitable for undergraduate introductory physics level. Examples include experiments that employ refraction, total internal reflection, diffraction and…

  12. Investigating First Year Elementary Mathematics Teacher Education Students' Knowledge of Prism

    Bozkurt, Ali; Koc, Yusuf

    2012-01-01

    The purpose of this study was to investigate first year elementary mathematics teacher education students' knowledge of prism. For this goal, the participants were asked to define the geometric concept of prism. The participants were 158 first year elementary mathematics teacher education students from a public university in Southern Turkey. The…

  13. Prism foil from an LCD monitor as a tool for teaching introductory optics

    Transparent prism foil is part of a backlight system in LCD monitors that are widely used today. This paper describes the optical properties of the prism foil and several pedagogical applications suitable for undergraduate introductory physics level. Examples include experiments that employ refraction, total internal reflection, diffraction and image formation in a nontrivial way and are therefore particularly useful for active learning strategies.

  14. Hierarchically triangular prism structured Co3O4: Self-supported fabrication and photocatalytic property

    The formation of ammonium cobalt (II) phosphate was utilized to synthesize unprecedented 3D structures of Co3O4, triangular prisms and trunk-like structures, via a self-supported and organics-free method. The length of a triangular side of the prepared 3D triangular prisms is ~1...

  15. DEVELOPMENT OF A NEW OREGON PRECIPITATION MAP USING THE PRISM MODEL

    Significant progress in our ability to distribute point monthly and annual precipitation data to a regular grid in complex terrain has recently been achieved through the development of PRISM (Precipitation-elevation Regressions on Independent Slopes Model) . PRISM is well suited ...

  16. Simultaneous adaptation of the thumb and index finger of the same hand to opposite prism displacements

    Schot, Willemijn D; Brenner, Eli; Smeets, Jeroen B J

    2014-01-01

    It only takes a few goal-directed hand movements to adapt one's movements to a prism-induced displacement of the visual scene. Adaptation to the displacement leads to errors in the opposite direction from the initial displacement when the prisms are removed. Such aftereffects are thought to arise fr

  17. Electron sharing and anion-π recognition in molecular triangular prisms.

    Schneebeli, Severin T; Frasconi, Marco; Liu, Zhichang; Wu, Yilei; Gardner, Daniel M; Strutt, Nathan L; Cheng, Chuyang; Carmieli, Raanan; Wasielewski, Michael R; Stoddart, J Fraser

    2013-12-01

    Stacking on a full belly: Triangular molecular prisms display electron sharing among their triangularly arranged naphthalenediimide (NDI) redox centers. Their electron-deficient cavities encapsulate linear triiodide anions, leading to the formation of supramolecular helices in the solid state. Chirality transfer is observed from the six chiral centers of the filled prisms to the single-handed helices. PMID:24227594

  18. Relationship between Timing Jitter and Prism Separation in Mode-locked Solid State Lasers

    LU Hong

    2001-01-01

    The function expression of the group delay dispersion (GDD) depending on the prism separation and the normal displacement is derived, and that the GDD is proportional to the prism separation and near to a linear function of the normal displacement in the case of small normal displacement are found. Then we discuss the timing jitter caused by the amplified spontaneous emission (ASE) which depends on the prism separation and the normal displacement. We find that the timing jitter is near to a linear function of the prism separation and can be regrded as a linear function of the normal displacement in the case of small normal displacement. Based on the theoretic work, we suggest an experimental setup to measure the relationship between the timing jitter and the prism separation or the normal displacement.

  19. ePRISM: A case study in multiple proxy and mixed temporal resolution integration

    Robinson, Marci M.; Dowsett, Harry J.

    2010-01-01

    As part of the Pliocene Research, Interpretation and Synoptic Mapping (PRISM) Project, we present the ePRISM experiment designed I) to provide climate modelers with a reconstruction of an early Pliocene warm period that was warmer than the PRISM interval (similar to 3.3 to 3.0 Ma), yet still similar in many ways to modern conditions and 2) to provide an example of how best to integrate multiple-proxy sea surface temperature (SST) data from time series with varying degrees of temporal resolution and age control as we begin to build the next generation of PRISM, the PRISM4 reconstruction, spanning a constricted time interval. While it is possible to tie individual SST estimates to a single light (warm) oxygen isotope event, we find that the warm peak average of SST estimates over a narrowed time interval is preferential for paleoclimate reconstruction as it allows for the inclusion of more records of multiple paleotemperature proxies.

  20. Optical device with conical input and output prism faces

    Brunsden, Barry S.

    1981-01-01

    A device for radially translating radiation in which a right circular cylinder is provided at each end thereof with conical prism faces. The faces are oppositely extending and the device may be severed in the middle and separated to allow access to the central part of the beam. Radiation entering the input end of the device is radially translated such that radiation entering the input end at the perimeter is concentrated toward the output central axis and radiation at the input central axis is dispersed toward the output perimeter. Devices are disclosed for compressing beam energy to enhance drilling techniques, for beam manipulation of optical spatial frequencies in the Fourier plane and for simplification of dark field and color contrast microscopy. Both refracting and reflecting devices are disclosed.

  1. Cosmic topology of prism double-action manifolds

    The cosmic microwave background (CMB) anisotropies in spherical 3-spaces with a non-trivial topology are studied. This paper discusses the special class of the so-called double-action manifolds, which are for the first time analysed with respect to their CMB anisotropies. The CMB anisotropies are computed for all prism double-action manifolds generated by a binary dihedral and a cyclic group with a group order of up to 180 leading to 33 different topologies. Several spaces are found which show a suppression of the CMB anisotropies on large angular distances as it is found on the real CMB sky. It turns out that two of these spaces possess Dirichlet domains which are not very far from highly symmetric polyhedra like Platonic or Archimedean ones. (paper)

  2. Mass spectrometers based on a cone-shaped acromatic prism

    We have elaborated a mass spectrometer without lenses consisting of one conic achromatic prism. It has a specific mass dispersion which is equal to 67.5 mm/m per 1% change of mass. (By specific dispersion we mean linear dispersion related to the main path.) The pass of charged particles with different emittance is investigated with the help of integrating precise equations for tracks of charged particles in natural curvilinear coordinates. We have calculated the resolving power and aberration of a mass spectrometer for different beams of particles. It is evident that the mass spectrometer is particularly effective in use when we deal with rather wide ion beams having an insignificant angular divergence in the mean plane. (orig.)

  3. Acoustic Prism for Continuous Beam Steering Based on Piezoelectric Metamaterial

    Xu, Jiawen

    2016-01-01

    This paper investigates an acoustic prism for continuous acoustic beam steering by a simple frequency sweep. This idea takes advantages of acoustic wave velocity shifting in metamaterials in the vicinity of local resonance. We apply this concept into the piezoelectric metamaterial consisting of host medium and piezoelectric LC shunt. Theoretical modeling and FEM simulations are carried out. It is shown that the phase velocity of acoustic wave changes dramatically in the vicinity of local resonance. The directions of acoustic wave can be adjusted continuously between 2 to 16 degrees by a simple sweep of the excitation frequency. Such an electro-mechanical coupling system has a feature of adjusting local resonance without altering the mechanical part of the system.

  4. A VUV prism spectrometer for RICH radiator refractometry

    Moyssides, P G; Fokitis, E

    2000-01-01

    A prism spectrometer has been developed to operate in the VUV wavelength range from 120 to 200 nm. It can be used as a pre- disperser in conjunction with a Fabry-Perot based gas refractometer. This instrument has also been used to measure the refractive index of the liquid radiator C/sub 6/F/sub 14/ in various spectral lines. This radiator is used in the RICH detectors of the DELPHI experiment and has been proposed for ALICE, and LHCb experiments. The spectral resolution of the system is improved as the wavelength decreases and the data are consistent with a wavelength accuracy about 0.4 nm at 140 nm. The results for the dispersion curve of the above liquid are presented. (17 refs).

  5. Mass spectrometers based on a cone-shaped acromatic prism

    Spivak-Lavrov, I.F. [Pedagogical Inst. of Aktyubinsk (Kazakhstan)

    1995-09-01

    We have elaborated a mass spectrometer without lenses consisting of one conic achromatic prism. It has a specific mass dispersion which is equal to 67.5 mm/m per 1% change of mass. (By specific dispersion we mean linear dispersion related to the main path.) The pass of charged particles with different emittance is investigated with the help of integrating precise equations for tracks of charged particles in natural curvilinear coordinates. We have calculated the resolving power and aberration of a mass spectrometer for different beams of particles. It is evident that the mass spectrometer is particularly effective in use when we deal with rather wide ion beams having an insignificant angular divergence in the mean plane. (orig.).

  6. R&D proposal the prism plastic calorimeter:PPC

    Dobrzynski, Ludwik; Marchand, P; Nédélec, P; Salin, P; CERN. Geneva. Detector Research and Development Committee

    1990-01-01

    This proposal supports two goals: First Goal_Demonstrate that current, widely used plastic technologies allow to design Prism Plastic Calorimeter (PPC) towers with a new "liquid crystal" type plastic called Vectra. It will be shown that this technique meets the requirements for a LHC calorimeter with warm liquids: safety, hermeticity, hadronic compensation, resolution and time response. Second Goal_ Describe how one can design a warm liquid calorimeter integrated into a LHC detector,and list the advantages of the PPC: low price, minimum of mechanical structures, minimum amount of dead space, easiness of mechanical assembly, accessibility to the electronics, possibility to recirculate the liquid. The absorber and the electronics being outside the liquid and easily accessible, one has maximum flexibility to define them. The R&D program we define here aims at showing the feasibility of these new ideas by building nine towers of twenty gaps and exposing them to electron and hadron beams.

  7. Structure of a growing accretionary prism, Hikurangi margin, New Zealand

    Davey, F. J.; Hampton, M.; Childs, J.; Fisher, M. A.; Lewis, K.; Pettinga, J. R.

    1986-08-01

    The Hikurangi margin of eastern North Island, New Zealand, represents the feather edge of the Indian plate at its convergent boundary with the subducting Pacific plate. A migrated seismic reflection profile across this margin clearly displays the structural evolution of an accretionary prism. A 25-km-wide band of “protothrusts” is delineated between the toe of the slope and a converging seamount; this illustrates an early stage in the seaward propagation of a deformation front. Landward-tilted trench-slope basins are separated by ridges that have clearly defined thrusts, which appear to sole out at a decollement. The decollement continues at an angle of only 3° beneath the 150-km-wide margin to a depth of 14 km near the coast where it coincides with an onshore zone of high seismicity.

  8. Larmor labeling of neutron spin using superconducting Wollaston prisms

    Li, Fankang

    Neutron spin Larmor labeling using magnetic Wollaston prisms (WP) provides a way to overcome some of the limitations arising from the nature of neutron beams: low flux and divergence. Using superconducting films and tapes, a series of strong, well-defined shaped magnetic fields can be produced due to both the zero-resistance and Meissner effect in superconductors. Using finite element simulations, the criterion to build a superconducting magnetic Wollaston prism with high encoding efficiency and low Larmor phase aberrations are presented. To achieve a high magnetic field and simplify the maintenance, we optimize the design using careful thermal analysis. The measured neutron spin flipping efficiency is measured to be independent of both the neutron wavelength and energizing current, which is a significant improvement over other devices with similar functions. A highly linear variation of the Larmor phase is measured across the device, which ensures a highly uniform encoding of scattering angles into the neutron spin Larmor phase. Using two WPs, the correlation function for a colloidal silica sample was measured by spin echo modulated small angle neutron scattering (SEMSANS) and agrees well with other techniques. Using Monte Carlo code (McStas), we further investigated the SEMSANS setup and showed the requirements to improve its performance. We have proposed a new technique to implement neutron spin echo on a triple axis neutron spectrometer to achieve high resolution measurements of the lifetime of dispersive phonon excitations. The spin echo is tuned by appropriate choice of magnetic fields instead of physically tilting the coils used in traditional methods. This new approach allows a higher energy resolution and a larger effective tilting angle and hence larger group velocity to be measured.

  9. Prevalence of antibody to Hepatitis B core antigen and Hepatitis B virus DNA in HBsAg negative healthy blood donors

    Karimi, Gharib; Zadsar, Maryam; Vafaei, Nasrin; SHARIFI, Zohreh; FalahTafti, Mohammad

    2016-01-01

    Background Hepatitis B virus is one of the most important blood born viruses. Although the sensitivity of screening tests has been considerably increased, transmission may still occur due to window period or occult hepatitis B infections (OBIs). This study was aimed at evaluating the prevalence of the anti-HBc and identifying the HBV DNA in HBsAg negative blood donors. Methods The Blood samples from 2031 HBsAg-negative blood donors were divided into three aliquots and tested for anti-HBc, ant...

  10. Quantitative HBsAg and HBeAg predict hepatitis B seroconversion after initiation of HAART in HIV-HBV coinfected individuals.

    Gail V Matthews

    Full Text Available OBJECTIVE: Anti-HBe seroconversion and HBsAg loss are important therapeutic endpoints in patients with hepatitis B virus (HBV infection. Quantitative measures of hepatitis B surface antigen (qHBsAg and e antigen (qHBeAg have been identified as potentially useful indicators of therapeutic response in HBV monoinfection. The aim of this study was to examine serological change including quantitative biomarkers in HIV-HBV coinfected patients initiating HBV active antiretroviral therapy (ART. METHODS: HIV-HBV coinfected individuals from Thailand were followed for up to 168 weeks post ART. Rates and associations of qualitative serological change were determined. Longitudinal changes in qHBsAg and qHBeAg were measured and their utility as predictors of response examined. RESULTS: Forty seven patients were included of whom 27 (57% were HBeAg positive at baseline. Median CD4 count was 48 cells/mm(3. Over a median follow-up of 108 weeks 48% (13/27 lost HBeAg, 12/27 (44% achieved anti-HBe seroconversion and 13% (6/47 HBsAg loss. Anti-HBe seroconversion was associated with higher baseline ALT (p = 0.034, lower qHBsAg (p = 0.015, lower qHBeAg (p = 0.031 and greater HBV DNA decline to week 24 (p = 0.045. Sensitivity and specificity for qHBsAg and qHBeAg decline of >0.5 log at week 12 and >1.0 log at week 24 were high for both anti-HBe seroconversion and HBsAg loss. CONCLUSIONS: Rates of serological change in these HIV-HBV coinfected individuals with advanced immunodeficiency initiating HBV-active ART were high. Baseline and on treatment factors were identified that were associated with a greater likelihood of subsequent anti-HBe seroconversion, including both quantitative HBsAg and HBeAg, suggesting these biomarkers may have utility in this clinical setting.

  11. Infección oculta por el virus de la hepatitis B en hijos de madres positivas al HBsAg

    Marité Bello-Corredor

    2016-04-01

    Full Text Available La infección oculta por el virus de la hepatitis B (IOB, se caracteriza por la presencia en suero o plasma del genoma viral (ADN-VHB y anticuerpos contra la proteína de la cápside (anti-HBc en ausencia del antígeno de superficie (HBsAg, marcador que tradicionalmente se emplea para identificar la presencia del virus. Con el objetivo de caracterizar la presencia de IOB en hijos de madres positivas al HBsAg, se estudiaron 291 muestras séricas de niños con la condición de ser HBsAg (- y anticuerpos anti-HBsAg (anti-HBs menores de 50 UI/L, conservadas en la seroteca del Laboratorio de Referencia Nacional de Hepatitis Virales. Se realizaron ensayos para determinar la exposición al virus (anti-HBc, a los sueros anti-HBc (+ se les realizó Reacción en Cadena de la Polimerasa en Tiempo Real (RCP-TR para determinar y cuantificar el ADN-VHB. La prevalencia de exposición al VHB (anti-HBc fue 16,8% (49/291. El ADN viral se cuantificó en el 14% (6/43 de los casos anti-HBc (+, observándose cargas virales que oscilaban entre 2,15 x 101 hasta 3,42 x 101 UI/mL. La prevalencia de la IOB para el total de los pacientes analizados fue 2,1% (6/291, considerada relativamente baja. No se encontró asociación significativa entre las variables sociodemográficas analizadas tales como: edad, sexo y provincia de procedencia. La IOB está presente en hijos de madres positivas al HBsAg, a pesar de la profilaxis contra la hepatitis B. Por lo tanto, se requiere de pesquisajes adecuados para detectar dicha entidad. Las implicaciones clínicas y epidemiológicas de la misma, requieren de un estrecho monitoreo y atención de estos pacientes. Este estudio se realiza por primera vez en Cuba y aporta conocimientos útiles para el diagnóstico, prevención y control de esta enfermedad en niños.

  12. Results of the Abbott RealTime HIV-1 Assay for Specimens Yielding “Target Not Detected” Results by the Cobas AmpliPrep/Cobas TaqMan HIV-1 Test▿

    Babady, N. Esther; Germer, Jeffrey J.; Yao, Joseph D. C.

    2009-01-01

    No significantly discordant results were observed between the Abbott RealTime HIV-1 assay and the COBAS AmpliPrep/COBAS TaqMan HIV-1 Test (CTM) among 1,190 unique clinical plasma specimens obtained from laboratories located in 40 states representing all nine U.S. geographic regions and previously yielding “target not detected” results by CTM.

  13. Multi-energy CT based on a prior rank, intensity and sparsity model (PRISM)

    We propose a compressive sensing approach for multi-energy computed tomography (CT), namely the prior rank, intensity and sparsity model (PRISM). To further compress the multi-energy image for allowing the reconstruction with fewer CT data and less radiation dose, the PRISM models a multi-energy image as the superposition of a low-rank matrix and a sparse matrix (with row dimension in space and column dimension in energy), where the low-rank matrix corresponds to the stationary background over energy that has a low matrix rank, and the sparse matrix represents the rest of distinct spectral features that are often sparse. Distinct from previous methods, the PRISM utilizes the generalized rank, e.g., the matrix rank of tight-frame transform of a multi-energy image, which offers a way to characterize the multi-level and multi-filtered image coherence across the energy spectrum. Besides, the energy-dependent intensity information can be incorporated into the PRISM in terms of the spectral curves for base materials, with which the restoration of the multi-energy image becomes the reconstruction of the energy-independent material composition matrix. In other words, the PRISM utilizes prior knowledge on the generalized rank and sparsity of a multi-energy image, and intensity/spectral characteristics of base materials. Furthermore, we develop an accurate and fast split Bregman method for the PRISM and demonstrate the superior performance of the PRISM relative to several competing methods in simulations. (papers)

  14. Left-Deviating Prism Adaptation in Left Neglect Patient: Reflexions on a Negative Result

    Jacques Luauté

    2012-01-01

    Full Text Available Adaptation to right-deviating prisms is a promising intervention for the rehabilitation of patients with left spatial neglect. In order to test the lateral specificity of prism adaptation on left neglect, the present study evaluated the effect of left-deviating prism on straight-ahead pointing movements and on several classical neuropsychological tests in a group of five right brain-damaged patients with left spatial neglect. A group of healthy subjects was also included for comparison purposes. After a single session of exposing simple manual pointing to left-deviating prisms, contrary to healthy controls, none of the patients showed a reliable change of the straight-ahead pointing movement in the dark. No significant modification of attentional paper-and-pencil tasks was either observed immediately or 2 hours after prism adaptation. These results suggest that the therapeutic effect of prism adaptation on left spatial neglect relies on a specific lateralized mechanism. Evidence for a directional effect for prism adaptation both in terms of the side of the visuomanual adaptation and therefore possibly in terms of the side of brain affected by the stimulation is discussed.

  15. Multi-energy CT based on a prior rank, intensity and sparsity model (PRISM).

    Gao, Hao; Yu, Hengyong; Osher, Stanley; Wang, Ge

    2011-11-01

    We propose a compressive sensing approach for multi-energy computed tomography (CT), namely the prior rank, intensity and sparsity model (PRISM). To further compress the multi-energy image for allowing the reconstruction with fewer CT data and less radiation dose, the PRISM models a multi-energy image as the superposition of a low-rank matrix and a sparse matrix (with row dimension in space and column dimension in energy), where the low-rank matrix corresponds to the stationary background over energy that has a low matrix rank, and the sparse matrix represents the rest of distinct spectral features that are often sparse. Distinct from previous methods, the PRISM utilizes the generalized rank, e.g., the matrix rank of tight-frame transform of a multi-energy image, which offers a way to characterize the multi-level and multi-filtered image coherence across the energy spectrum. Besides, the energy-dependent intensity information can be incorporated into the PRISM in terms of the spectral curves for base materials, with which the restoration of the multi-energy image becomes the reconstruction of the energy-independent material composition matrix. In other words, the PRISM utilizes prior knowledge on the generalized rank and sparsity of a multi-energy image, and intensity/spectral characteristics of base materials. Furthermore, we develop an accurate and fast split Bregman method for the PRISM and demonstrate the superior performance of the PRISM relative to several competing methods in simulations. PMID:22223929

  16. The penta-prism LTP: A long-trace-profiler with stationary optical head and moving penta prism (abstract)

    Metrology requirements for optical components for third generation synchrotron sources are taxing the state-of-the-art in manufacturing technology. We have investigated a number of effect sources in a commercial figure measurement instrument, the Long Trace Profiler II (LTP II), and have demonstrated that, with some simple modifications, we can significantly reduce the effect of error sources and improve the accuracy and reliability of the measurement. By keeping the optical head stationary and moving a penta prism along the translation stage, the stability of the optical system is greatly improved, and the remaining error signals can be corrected by a simple reference beam subtraction. We illustrate the performance of the modified system by investigating the distortion produced by gravity on a typical synchrotron mirror and demonstrate the repeatability of the instrument despite relaxed tolerances on the translation stage

  17. Assessment of hydrologic and water quality data collected in Abbotts Lagoon watershed, Point Reyes National Seashore, California, during water years 1999 and 2000

    Kratzer, Charles R.; Saleh, Dina K.; Zamora, Celia

    2006-01-01

    Abbotts Lagoon is part of Point Reyes National Seashore, located about 40 miles northwest of San Francisco and about 20 miles south of Bodega Bay. Water-quality samples were collected quarterly during water year 1999 at a site in each of three connected lagoons that make up Abbotts Lagoon and at a site in its most significant tributary. The quarterly samples were analyzed for major ions, nutrients, and chlorophyll-a. A bed-sediment sample was collected in each lagoon during August 1999 and was analyzed for organic carbon, iron, and total phosphorus. Seven tributaries were sampled during a February 1999 storm and four during an April 1999 storm. These samples were analyzed only for nutrients. One storm sample collected in April 1999 from a tributary downstream of the I Ranch dairy was analyzed for a suite of 47 compounds indicative of wastewater. Continuous water-level recorders were installed in the most significant tributary and the two largest lagoons for portions of the study. A water budget analysis for an April 2000 storm indicated that the main tributary accounted for 85 percent of surface inflows to Abbotts Lagoon. The portion of the surface inflow from the main tributary was lower in the February 1999 storms and is a function of upstream storage and vegetative growth in the tributary basins. Another water budget analysis for a period of no surface inflow (June and July 2000) indicated that the net ground-water contribution was an outflow (seepage) from Abbotts Lagoon of about 0.3 ft3/s. Salinity increased and nutrient concentrations decreased from upstream to downstream in the chain of lagoons. The lower lagoon, nearest the ocean, had less organic carbon and total phosphorus in the bed sediment than the upper lagoons. The two tributaries originating in the I Ranch dairy had the highest concentrations of nutrients in storm runoff, and the highest loading rates and yields of ammonia and phosphorus. These tributaries account for only 10.3 percent of the area

  18. Analysis of an Attenuator Artifact in an Experimental Attack by Gunn-Allison-Abbott Against the Kirchhoff-Law-Johnson-Noise (KLJN) Secure Key Exchange System

    Kish, Laszlo B.; Gingl, Zoltan; Mingesz, Robert; Vadai, Gergely; Smulko, Janusz; Granqvist, Claes-Göran

    2015-12-01

    A recent paper by Gunn-Allison-Abbott (GAA) [L. J. Gunn et al., Scientific Reports 4 (2014) 6461] argued that the Kirchhoff-law-Johnson-noise (KLJN) secure key exchange system could experience a severe information leak. Here we refute their results and demonstrate that GAA's arguments ensue from a serious design flaw in their system. Specifically, an attenuator broke the single Kirchhoff-loop into two coupled loops, which is an incorrect operation since the single loop is essential for the security in the KLJN system, and hence GAA's asserted information leak is trivial. Another consequence is that a fully defended KLJN system would not be able to function due to its built-in current-comparison defense against active (invasive) attacks. In this paper we crack GAA's scheme via an elementary current-comparison attack which yields negligible error probability for Eve even without averaging over the correlation time of the noise.

  19. Enhanced performance of wind energy harvester by aerodynamic treatment of a square prism

    Hu, Gang; Tse, K. T.; Kwok, K. C. S.

    2016-03-01

    This letter presents the effects that fitting fins to various corners of a square-prism galloping-based piezoelectric energy harvester (PEH) has on its performance, based on results from a series of wind tunnel model tests. The results show that attaching fins to the leading edge significantly improves the efficiency of the harvester, achieving a maximum power 2.5 times that attained by a plain square prism PEH. Furthermore, a length that is 1/6 of the prism's cross-sectional width is found to be optimal for fins that are attached to the harvester.

  20. Does prism width from the shell prismatic layer have a random distribution?

    Verrecchia, Eric P.; Vancolen, Séverine

    2009-01-01

    A study of the distribution of the prism width inside the prismatic layer of Unio tumidus (Philipsson 1788, Diss Hist-Nat, Berling, Lundæ) from Lake Neuchâtel, Switzerland, has been conducted in order to determine whether or not this distribution is random. Measurements of 954 to 1,343 prism widths (depending on shell sample) have been made using a scanning electron microscope in backscattered electron mode. A white noise test has been applied to the distribution of prism sizes (i.e. width). ...

  1. Construction and immunological evaluation of truncated hepatitis B core particles carrying HBsAg amino acids 119-152 in the major immunodominant region (MIR).

    Su, Qiudong; Yi, Yao; Guo, Minzhuo; Qiu, Feng; Jia, Zhiyuan; Lu, Xuexin; Meng, Qingling; Bi, Shengli

    2013-09-13

    Hepatitis B capsid protein expressed in Escherichia coli can reassemble into icosahedral particles, which could strongly enhance the immunogenicity of foreign epitopes, especially those inserted into its major immunodominant region. Herein, we inserted the entire 'α' antigenic determinant amino acids (aa) 119-152 of HBsAg into the truncated HBc (aa 1-144), between Asp(78) and Pro(79). Prokaryotic expression showed that the mosaic HBc was mainly in the form of inclusion bodies. After denaturation with urea, it was dialyzed progressively for protein renaturation. We observed that before and after renaturation, mosaic HBc was antigenic as determined by HBsAg ELISA and a lot of viruslike particles were observed after renaturation. Thus, we further purified the mosaic viruslike particles by (NH4)2SO4 precipitation, DEAE chromatography, and Sepharose 4FF chromatography. Negative staining electron microscopy demonstrated the morphology of the viruslike particles. Immunization of Balb/c mice with mosaic particles induced the production of anti-HBs antibody and Th1 cell immune response supported by ELISPOT and CD4/CD8 proportions assay. In conclusion, we constructed mosaic hepatitis core particles displaying the entire 'α' antigenic determinant on the surface and laid a foundation for researching therapeutic hepatits B vaccines. PMID:23969156

  2. Prism-C2n carbon dimer, trimer, and nano-sheets: A quantum chemical study

    Ohno, Koichi; Satoh, Hiroko; Iwamoto, Takeaki

    2015-07-01

    Quantum chemical calculations have predicted the existence of a new carbon family with double-layered structures formed by arranging prism-C2n (n = 6, 8, and 12) units. Theoretical explorations of potential energy surfaces suggest the lowest barriers of the reaction channels to be ca. 30 kJ mol-1 for a D2h prism-C16 dimer and a D3h prism-C24 trimer. Geometry optimizations under periodic boundary conditions yield some prism-C2n sheets composed of CC single bonds of ca. 0.15-0.16 nm. The relative energies per one atom with respect to graphene are 90-160 kJ mol-1. Van der Waals thickness is estimated to be ca. 0.5 nm.

  3. Finite layer and triangular prism element method to subsidence prediction and stress analysis in underground mining

    LIU Li-min(刘立民); LIU Han-long(刘汉龙); LIAN Chuan-jie(连传杰)

    2003-01-01

    The application of the finite layer & triangular prism element method to the 3D ground subsidence and stress analysis caused by mining is presented. The layer elements and the triangular prism elements have been alternatively used in the numerical simulation system, the displacement pattern, strain matrix, elastic matrix, stiffness matrix, load matrix and the stress matrix of the layer element and triangular prism element have been presented. By means of the Fortran90 programming language, a numerical simulation system based on finite layer & triangular prism element have been built up, and this system is suitable for subsidence prediction and stress analysis of all mining condition and mining methods. Comparing with the infinite element method, this approach dramatically reduces the size of the set of equations that need to be solved, and greatly reduces the amount of data preparation required. It not only saves the internal storage, and the computation time, but also decreases the cost.

  4. Improvement of Mental Imagery after Prism Exposure in Neglect: A Case Study

    Gilles Rode

    1999-01-01

    Full Text Available Previous work has shown that various symptoms of unilateral neglect, including the pathological shift of the subjective midline to the right, may be improved by a short adaptation period to a prismatic shift of the visual field to the right. We report here the improvement of imagined neglect after prism exposure in a patient with a left unilateral neglect. Despite a strong neglect observed for mental images as well as for conventional tests, the mental evocation of left-sided information from an internal image of the map of France map was fully recovered following prism adaptation to the right. This improvement could not be explained by the alteration of visuomotor responses induced by the prism adaptation. Prism adaptation may therefore act not only on sensory-motor levels but also on a higher cognitive level of mental space representation and/or exploration.

  5. Prism-assisted inclined UV lithography for 3D microstructure fabrication

    A prism-assisted inclined ultraviolet (UV) lithography technique is introduced for the fabrication of three-dimensional (3D) microstructures. Slanted structures with exposure angles ranging from 0° to 60° in SU-8 photoresist have been easily achieved without immersion in the index matching liquid. The fabrication process of multidirectional slanted structures can be simplified by one-step UV exposure using a prism with multidirectional side surfaces. A corner prism and a cone prism have been used in our experiment to demonstrate this concept. Upside-down tripod structures and horn structures have been fabricated in one-step exposures. The effective exposure area as one key parameter of the one-step exposure is analyzed for practical applications. Examples of various 3D microstructures fabricated by this method are presented. (paper)

  6. A study on transmitted intensity's perturbance for air-spaced Glan-type polarizing prisms

    Fan, J Y; Wu, F Q; Fan, Ji-Yang; Li, Hong-Xia; Wu, Fu-Quan

    2003-01-01

    The explanation for the perturbance of the transmitted intensity for air-spaced Glan-type polarizing prisms with varying rotation angle newly observed in the experiment is given. It is found that the transmitted intensity depends sensitively on the angle of incidence at the cut of the Glan-type prism. The minute fluctuation for values of the angle of incidence during the rotation of the stepmotor gives rise to the perturbance. The relation between the perturbance and the wavelength and the thickness of the air-gap is carefully investigated. Study shows that the disturbance for the Glan-Foucault prism is much stronger than that for the Glan-Taylor prism, as the experimental results have indicated. Theoretical results are perfectly in accordance with the experimental results. Effective measures for reducing the disturbance are presented.

  7. TEST METHOD FOR SINGLE INTERIOR RIGHT ANGLE IN A CORNER CUBE PRISM

    2000-01-01

    A new test method for single interior right angle in a corner cube prism is presented. Some key points and parameters are analyzed and derived. The advantage of this method is concluded by comparing with some current conventional methods.

  8. Fusional Vergence Detected by Prism Bar and Synoptophore in Chinese Childhood Intermittent Exotropia

    2015-01-01

    Purpose. To measure the changes in fusional vergence in Chinese children with intermittent exotropia (IXT) and the association with the control of IXT. Methods. Ninety-two patients with IXT (8–15 years old) were compared with 86 controls. Exodeviation control was evaluated using the Revised Newcastle Control Score. Angle of deviation was measured using prism and alternate cover testing at distance and near. Fusional vergence was measured using prism bar and synoptophore. This study was regist...

  9. PRISM (Polarized Radiation Imaging and Spectroscopy Mission): an extended white paper

    PRISM Collaboration

    2014-01-01

    PRISM (Polarized Radiation Imaging and Spectroscopy Mission) was proposed to ESA in May 2013 as a large-class mission for investigating within the framework of the ESA Cosmic Vision program a set of important scientific questions that require high resolution, high sensitivity, full-sky observations of the sky emission at wavelengths ranging from millimeter-wave to the far-infrared. PRISM's main objective is to explore the distant universe, probing cosmic history from very early times until no...

  10. The dual Jacobian of a generalised tetrahedron, and volumes of prisms

    Kolpakov, Alexander; Murakami, Jun

    2014-01-01

    We derive an analytic formula for the dual Jacobian matrix of a generalised hyperbolic tetrahedron. Two cases are considered: a mildly truncated and a prism truncated tetrahedron. The Jacobian for the latter arises as an analytic continuation of the former, that falls in line with a similar behaviour of the corresponding volume formulae. Also, we obtain a volume formula for a hyperbolic $n$-gonal prism: the proof requires the above mentioned Jacobian, employed in the analysis of the edge leng...

  11. Nitridation aspects of a basal and a prism plane textured Ti film

    High dose nitrogen implantation into a basal and a prism plane textured Ti film show differences in their end products. While the basal plane textured Ti film undergoes complete transformation to δ-TiN for a dose of 3 x 1017 ions/cm2, the prism plane textured film has a mixture of Ti and TiN for the same dose. The results indicate that the texture of the starting material has synergistic effects on the phase transformation. (author)

  12. Effects of prism adaptation on motor-intentional spatial bias in neglect

    Fortis, Paola; Chen, Peii; Goedert, Kelly M.; Barrett, Anna M.

    2011-01-01

    Prism adaptation may alleviate some symptoms of spatial neglect. However, the mechanism through which this technique works is still unclear. The current study investigated whether prism adaptation differentially affects dysfunction in perceptual-attentional “where” versus motor-intentional “aiming” bias. Five neglect patients performed a line bisection task in which lines were viewed under both normal and right-left reversed viewing conditions, allowing for the fractionation of “where” and “a...

  13. PERANCANGAN DAN IMPLEMENTASI SISTEM PENGUKURAN KINERJA DENGAN METODE PERFORMANCE PRISM (Studi Kasus pada Hotel X)

    Iwan Vanany; Dian Tanukhidah

    2004-01-01

    This article described a result of research design of performance measurement system in hotel business with Performance Prism Model. As long as, performance measurement system at hotel X not yet representatived organization performance according to comprehensif and integrated. Because of needed redesign performance measurement system with new model. From the objective condition of hotel X, Performance Prism model more representative than others. The result of design described that stakeholder...

  14. PrismTech Data Distribution Service Java API Evaluation

    Riggs, Cortney

    2008-01-01

    My internship duties with Launch Control Systems required me to start performance testing of an Object Management Group's (OMG) Data Distribution Service (DDS) specification implementation by PrismTech Limited through the Java programming language application programming interface (API). DDS is a networking middleware for Real-Time Data Distribution. The performance testing involves latency, redundant publishers, extended duration, redundant failover, and read performance. Time constraints allowed only for a data throughput test. I have designed the testing applications to perform all performance tests when time is allowed. Performance evaluation data such as megabits per second and central processing unit (CPU) time consumption were not easily attainable through the Java programming language; they required new methods and classes created in the test applications. Evaluation of this product showed the rate that data can be sent across the network. Performance rates are better on Linux platforms than AIX and Sun platforms. Compared to previous C++ programming language API, the performance evaluation also shows the language differences for the implementation. The Java API of the DDS has a lower throughput performance than the C++ API.

  15. PRISM: A DATA-DRIVEN PLATFORM FOR MONITORING MENTAL HEALTH.

    Kamdar, Maulik R; Wu, Michelle J

    2016-01-01

    Neuropsychiatric disorders are the leading cause of disability worldwide and there is no gold standard currently available for the measurement of mental health. This issue is exacerbated by the fact that the information physicians use to diagnose these disorders is episodic and often subjective. Current methods to monitor mental health involve the use of subjective DSM-5 guidelines, and advances in EEG and video monitoring technologies have not been widely adopted due to invasiveness and inconvenience. Wearable technologies have surfaced as a ubiquitous and unobtrusive method for providing continuous, quantitative data about a patient. Here, we introduce PRISM-Passive, Real-time Information for Sensing Mental Health. This platform integrates motion, light and heart rate data from a smart watch application with user interactions and text entries from a web application. We have demonstrated a proof of concept by collecting preliminary data through a pilot study of 13 subjects. We have engineered appropriate features and applied both unsupervised and supervised learning to develop models that are predictive of user-reported ratings of their emotional state, demonstrating that the data has the potential to be useful for evaluating mental health. This platform could allow patients and clinicians to leverage continuous streams of passive data for early and accurate diagnosis as well as constant monitoring of patients suffering from mental disorders. PMID:26776198

  16. Optical system design of the Dyson imaging spectrometer based on the Fery prism

    Pei, Linlin; Xiangli, Bin; Lv, Qunbo; Shao, Xiaopeng

    2016-08-01

    Imaging spectrometer has obtained wide development since rich feature information can be obtained by it; now, we focus on its high spectral resolution and miniaturization. In this paper, we design the Dyson imaging spectrometer system based on Fery prism. The average spectral resolution is 4.3 nm and the structure of the total length is 229 mm. It is a small, high-spectrometer imaging system. The front and rear surface of the traditional prism are plane, but the surfaces of the Fery prism are spherical, which can provide some optical power to realize imaging function and produce the dispersion effect. The Fery prism does not need to be placed in the parallel optical path, which simplifies the collimator lens and the imaging lens and are necessary in the prism spectrometer, making it possible to obtain a compact spectrometer. Full-spectrum transmittance of the prism is up to 94 %. Compared to the convex grating, the energy efficiency is greatly improved, and the free spectral range is wider, and its dispersion will not bring higher-order spectral aliasing problem. The small high spectrometer only includes two components. Its spectral range is from 400 to 1000 nm, covering the near-ultraviolet to near-infrared. The various aberrations of the typical spectrum are corrected. The spectrometer is excellent in performance.

  17. Rhomboid prism pair for rotating the plane of parallel light beams

    Orloff, K. L. (Inventor); Yanagita, H.

    1982-01-01

    An optical system is described for rotating the plane defined by a pair of parallel light beams. In one embodiment a single pair of rhomboid prisms have their respective input faces disposed to receive the respective input beams. Each prism is rotated about an axis of revolution coaxial with each of the respective input beams by means of a suitable motor and gear arrangement to cause the plane of the parallel output beams to be rotated relative to the plane of the input beams. In a second embodiment, two pairs of rhomboid prisms are provided. In a first angular orientation of the output beams, the prisms merely decrease the lateral displacement of the output beams in order to keep in the same plane as the input beams. In a second angular orientation of the prisms, the input faces of the second pair of prisms are brought into coincidence with the input beams for rotating the plane of the output beams by a substantial angle such as 90 deg.

  18. Optical system design of the Dyson imaging spectrometer based on the Fery prism

    Pei, Linlin; Xiangli, Bin; Lv, Qunbo; Shao, Xiaopeng

    2016-07-01

    Imaging spectrometer has obtained wide development since rich feature information can be obtained by it; now, we focus on its high spectral resolution and miniaturization. In this paper, we design the Dyson imaging spectrometer system based on Fery prism. The average spectral resolution is 4.3 nm and the structure of the total length is 229 mm. It is a small, high-spectrometer imaging system. The front and rear surface of the traditional prism are plane, but the surfaces of the Fery prism are spherical, which can provide some optical power to realize imaging function and produce the dispersion effect. The Fery prism does not need to be placed in the parallel optical path, which simplifies the collimator lens and the imaging lens and are necessary in the prism spectrometer, making it possible to obtain a compact spectrometer. Full-spectrum transmittance of the prism is up to 94 %. Compared to the convex grating, the energy efficiency is greatly improved, and the free spectral range is wider, and its dispersion will not bring higher-order spectral aliasing problem. The small high spectrometer only includes two components. Its spectral range is from 400 to 1000 nm, covering the near-ultraviolet to near-infrared. The various aberrations of the typical spectrum are corrected. The spectrometer is excellent in performance.

  19. Multiplicity of carbohydrate-binding sites in -prism fold lectins: occurrence and possible evolutionary implications

    Alok Sharma; Divya Chandran; Desh D Singh; M Vijayan

    2007-09-01

    The -prism II fold lectins of known structure, all from monocots, invariably have three carbohydrate-binding sites in each subunit/domain. Until recently, -prism I fold lectins of known structure were all from dicots and they exhibited one carbohydrate-binding site per subunit/domain. However, the recently determined structure of the -prism fold I lectin from banana, a monocot, has two very similar carbohydrate-binding sites. This prompted a detailed analysis of all the sequences appropriate for two-lectin folds and which carry one or more relevant carbohydrate-binding motifs. The very recent observation of a -prism I fold lectin, griffithsin, with three binding sites in each domain further confirmed the need for such an analysis. The analysis demonstrates substantial diversity in the number of binding sites unrelated to the taxonomical position of the plant source. However, the number of binding sites and the symmetry within the sequence exhibit reasonable correlation. The distribution of the two families of -prism fold lectins among plants and the number of binding sites in them, appear to suggest that both of them arose through successive gene duplication, fusion and divergent evolution of the same primitive carbohydrate-binding motif involving a Greek key. Analysis with sequences in individual Greek keys as independent units lends further support to this conclusion. It would seem that the preponderance of three carbohydrate-binding sites per domain in monocot lectins, particularly those with the -prism II fold, is related to the role of plant lectins in defence.

  20. The optimized of ELISA examines HBsAg the experimental condition%ELISA法检测HBsAg实验条件的优化

    郭翀; 张真铭

    2011-01-01

    To analysis temperature,the incubating time,the vibration examine HBsAg to the influence of the ELISA method,further in expectation of optimizes the experimental conditions. Methods The HBsAg blood serum specimen were used,which density approximately was 1 ng/mL,in four kinds of different experimental conditions (37 ℃ vibration, 37 ℃ no vibration,25 ℃ room temperatures vibrations,25 ℃ room temperatures no vibration) and three different reaction time (10 minutes, 20 minutes,30 minutes)determine HBSAg,and register the numerical value of the absorbency. Results except 37 ℃ no vibration and 25 ℃ room temperatures no vibration exzist no apparent differences(P>0.05), they exzist the apparent differences(P<0.05).Conclusion 37 ℃ and vibrating 20 minutes is the best optimized condition of this experiment.%目的 探讨温度、孵育时间、振荡对ELISA法检测HBsAg的影响,以期进一步优化检测条件.方法 采用HBsAg含量约为1 ng/mL的血清标本,在4种不同条件(37 ℃振荡、37 ℃不振荡、25 ℃室温震荡、25 ℃室温不振荡)下的3个不同反应时间(10、20、30 min)测定HBsAg,记录吸光度值.结果除10 min 37 ℃不振荡和25 ℃不振荡差异无统计学意义(P>0.05)外,其余各组差异都有统计学意义(P<0.05).结论 37 ℃振荡20 min为ELISA检测HBsAg的较佳条件.

  1. Extended-Range Ultrarefractive 1D Photonic Crystal Prisms

    Ting, David Z.

    2007-01-01

    by use of conventional prisms and diffraction gratings and is highly nonlinear.

  2. Planar scanning method for detecting refraction characteristics of two-dimensional photonic quasi-crystal wedge-shaped prisms.

    Liu, Jianjun; Tan, Wei; Liu, Exian; Hu, Haili; Fan, Zhigang; Zhang, Tianhua; Zhang, Xiong

    2016-05-01

    In this study, a planar scanning method is proposed. This novel method adapts two monitors moving along double planar tracks that can be used to detect refraction characteristics of two-dimensional (2D) photonic quasi-crystal (PQC) wedge-shaped prisms. Refraction of a decagonal Penrose-type PQC prism is analyzed for a given incident beam and two polarization modes at different incident positions in the prism using this method. Refraction from the prism is irregular, indicating that nonuniformity in the arrangement of scatterers in the prism causes Bragg-like scattering irregularities. Numerical results show that this method can be used for guiding the design of a 2D PQC prism and for the analysis of its refraction characteristics. PMID:27140896

  3. Construction and immunological evaluation of truncated hepatitis B core particles carrying HBsAg amino acids 119–152 in the major immunodominant region (MIR)

    Highlights: •The conformational HBV neutralization antigen domain was successfully displayed on the surface of truncated HBc particles. •Appropriate dialysis procedures to support the renaturing environment for the protein refolding. •Efficient purification procedures to obtain high purity and icosahedral particles of mosaic HBV antigen. •Strong immune responses not only including neutralization antibody response but also Th1 cell response were induced in mice. -- Abstract: Hepatitis B capsid protein expressed in Escherichia coli can reassemble into icosahedral particles, which could strongly enhance the immunogenicity of foreign epitopes, especially those inserted into its major immunodominant region. Herein, we inserted the entire ‘α’ antigenic determinant amino acids (aa) 119–152 of HBsAg into the truncated HBc (aa 1–144), between Asp78 and Pro79. Prokaryotic expression showed that the mosaic HBc was mainly in the form of inclusion bodies. After denaturation with urea, it was dialyzed progressively for protein renaturation. We observed that before and after renaturation, mosaic HBc was antigenic as determined by HBsAg ELISA and a lot of viruslike particles were observed after renaturation. Thus, we further purified the mosaic viruslike particles by (NH4)2SO4 precipitation, DEAE chromatography, and Sepharose 4FF chromatography. Negative staining electron microscopy demonstrated the morphology of the viruslike particles. Immunization of Balb/c mice with mosaic particles induced the production of anti-HBs antibody and Th1 cell immune response supported by ELISPOT and CD4/CD8 proportions assay. In conclusion, we constructed mosaic hepatitis core particles displaying the entire ‘α’ antigenic determinant on the surface and laid a foundation for researching therapeutic hepatits B vaccines

  4. Construction and immunological evaluation of truncated hepatitis B core particles carrying HBsAg amino acids 119–152 in the major immunodominant region (MIR)

    Su, Qiudong; Yi, Yao [National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing 102206 (China); Guo, Minzhuo [Beijing Entry-Exit Inspection and Quarantine Beureau, Tianshuiyuan Lane 6, Chaoyang District, Beijing 100026 (China); Qiu, Feng; Jia, Zhiyuan; Lu, Xuexin; Meng, Qingling [National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing 102206 (China); Bi, Shengli, E-mail: shengli_bi@163.com [National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing 102206 (China)

    2013-09-13

    Highlights: •The conformational HBV neutralization antigen domain was successfully displayed on the surface of truncated HBc particles. •Appropriate dialysis procedures to support the renaturing environment for the protein refolding. •Efficient purification procedures to obtain high purity and icosahedral particles of mosaic HBV antigen. •Strong immune responses not only including neutralization antibody response but also Th1 cell response were induced in mice. -- Abstract: Hepatitis B capsid protein expressed in Escherichia coli can reassemble into icosahedral particles, which could strongly enhance the immunogenicity of foreign epitopes, especially those inserted into its major immunodominant region. Herein, we inserted the entire ‘α’ antigenic determinant amino acids (aa) 119–152 of HBsAg into the truncated HBc (aa 1–144), between Asp{sup 78} and Pro{sup 79}. Prokaryotic expression showed that the mosaic HBc was mainly in the form of inclusion bodies. After denaturation with urea, it was dialyzed progressively for protein renaturation. We observed that before and after renaturation, mosaic HBc was antigenic as determined by HBsAg ELISA and a lot of viruslike particles were observed after renaturation. Thus, we further purified the mosaic viruslike particles by (NH{sub 4}){sub 2}SO{sub 4} precipitation, DEAE chromatography, and Sepharose 4FF chromatography. Negative staining electron microscopy demonstrated the morphology of the viruslike particles. Immunization of Balb/c mice with mosaic particles induced the production of anti-HBs antibody and Th1 cell immune response supported by ELISPOT and CD4/CD8 proportions assay. In conclusion, we constructed mosaic hepatitis core particles displaying the entire ‘α’ antigenic determinant on the surface and laid a foundation for researching therapeutic hepatits B vaccines.

  5. XeCl excimer laser with new prism resonator configurations and its performance characteristics

    New resonator cavity configurations, namely, the prism resonator and unstable prism resonator, are demonstrated for the first time in an excimer (XeCl) laser with interesting and novel results. High misalignment tolerance ∼50 mrad is achieved with considerably reduced beam divergence of less than ∼1 mrad without reduction in output power capabilities of the laser. The misalignment tolerance of ∼50 mrad is a dramatic improvement of ∼25 times compared to ∼2 mrad normally observed in standard excimer laser with plane-plane cavity. Increase in depth of focus from 3 mm to 5.5 mm was also achieved in case of prism resonator configuration with an improvement of about 60%. Unstable prism resonator configuration is demonstrated here in this paper with further reduction in beam divergence to about 0.5 mrad using plano-convex lens as output coupler. The misalignment tolerance in case of unstable prism resonator was retained at about 30 mrad which is a high value compared to standard unstable resonators. The output beam spot was completely filled with flat-top profile with prism resonator configurations, which is desired for various material processing applications. Focusing properties and beam divergence in case of prism resonator have been investigated using SEM (scanning electron microscope) images. SEM images of the focused spot size (∼20 μm holes) on metal sheet indicate beam divergence of about 0.05 mrad which is about 1.5 times diffraction limit. Energy contained in this angle is thus sufficient for micro-machining applications. Clean and sharp edges of the micro-holes show high pointing stability with multiple shot exposures. Such characteristics of the excimer laser system will be extremely useful in micro-machining and other field applications

  6. Comparison of three different recombinant hepatitis B vaccines: GeneVac-B, Engerix B and Shanvac B in high risk infants born to HBsAg positive mothers in India

    Velu, Vijayakumar; Nandakumar, Subhadra; Shanmugam, Saravanan; Jadhav, Suresh Sakharam; Kulkarni, Prasad Suryakant; Thyagarajan, Sadras Panchatcharam

    2007-01-01

    AIM: To evaluate a low cost Indian recombinant hepatitis B vaccine GeneVac-B® for its immunogenicity and safety in comparison to Engerix B® and Shanvac B® vaccine in high risk newborn infants born to hepatitis B surface antigen (HBsAg) positive mothers.

  7. Molecular detection and confirmation of Neisseria gonorrhoeae in urogenital and extragenital specimens using the Abbott CT/NG RealTime assay and an in-house assay targeting the porA pseudogene.

    Walsh, A

    2011-04-01

    Culture for detection of Neisseria gonorrhoeae (NG) is being replaced by molecular assays, but difficulties are observed with false positive and negatives results, especially for extragenital samples. This study evaluates the Abbott CT\\/NG Real-Time assay and a real-time porA pseudogene assay. Samples (n = 600) from a mixed prevalence Irish population include 164 male urines with corresponding urethral swabs, 58 endocervical swabs, 173 male pharyngeal swabs, 205 male rectal swabs, 36 NG clinical isolates and 26 commensal Neisseria species isolates. There was a 100% concordance between the Abbott CT\\/NG Real-Time and the porA assay. The positivity rate was 1.2%, 1.7%, 8.1% and 5.8% for FVU\\/urethral swabs, endocervical, pharyngeal and rectal swabs, respectively. These results were compared to culture and discrepancies were found with nine pharyngeal and three rectal swabs. Seven of the 12 discrepant positive samples were sequenced and were confirmed "true positives". The sensitivity and specificity of the molecular assays was 100%. The sensitivity of the culture-based testing was 100% for urogenital samples but 36% and 75% for pharyngeal and rectal swabs, respectively. The combined Abbott CT\\/NG and porA assays provide a valuable alternative to culture and also generate a significant increase in the diagnosis of pharyngeal and rectal NG infection.

  8. Synthesis of hexagonal wurtzite Cu2ZnSnS4 prisms by an ultrasound-assisted microwave solvothermal method

    Long, Fei; Chi, Shangsen; He, Jinyun; Wang, Jilin; Wu, Xiaoli; Mo, Shuyi; Zou, Zhengguang

    2015-09-01

    Wurtzite Cu2ZnSnS4 (CZTS) hexagonal prisms were synthesized by a simple ultrasound-microwave solvothermal method. The product was characterized by XRD, FESEM, EDS, TEM, Raman and UV-vis spectrometer. The hexagonal prisms were 0.5-2 μm wide and 5-12 μm long. The PVP played an important role in the formation of the CZTS hexagonal prisms. In addition, the ultrasound-assisted microwave process was helpful for synthesis of wurtzite rather than kesterite phase CZTS. A nucleation-dissolution-recrystallization mechanism was also proposed to explain the growth of the CZTS hexagonal prisms.

  9. Comparison of optical characteristics according to shape change based on micro prism pattern

    Je, Tae-Jin; Kim, Chang-Eui; Choi, Hwan-Jin; Kang, Myoung-Chang; Jeon, Eun-chae; Park, Min-gyu; Jo, Byeong-Muk; Lee, Bong-Jae

    2015-07-01

    For high-functional optical films composed of micro patterns, the optical properties, such as the diffraction, reflection and diffusion, depend on the pattern size, shape, and arrangement. For this reason, a high precision machining process and the technology of pattern design were studied in order to increase function and efficiency. The basic shapes of micro patterns are often prisms, square pyramids and triangular pyramids. Generally, a prism pattern on a flat surface can be continuously grooved by a diamond tool same as a shape angle of the pattern. The square pyramid shape is perpendicularly machined on the prism pattern. The triangular pyramid is made with a bisection of the square pyramid along the diagonal direction. Thus, optical properties can be changed according to prism patterns produced by mechanical machining. In this paper, prism, square pyramid and triangular pyramid pattern molds were machined, and optical properties of the respective shapes were compared. The machining experiment employed an ultra-precision 4-axis planer, V-shape diamond tools, and Cu-plating molds. The machined micro patterns were replicated using UV-resin; then light-transmission measurements were performed to confirm the optical properties of the mold pattern.

  10. Fusional Vergence Detected by Prism Bar and Synoptophore in Chinese Childhood Intermittent Exotropia

    Tao Fu

    2015-01-01

    Full Text Available Purpose. To measure the changes in fusional vergence in Chinese children with intermittent exotropia (IXT and the association with the control of IXT. Methods. Ninety-two patients with IXT (8–15 years old were compared with 86 controls. Exodeviation control was evaluated using the Revised Newcastle Control Score. Angle of deviation was measured using prism and alternate cover testing at distance and near. Fusional vergence was measured using prism bar and synoptophore. This study was registered with ChiCTR-RCC-13003920. Results. Using prism bar, convergence break points were lower whereas divergence break points were higher in children with IXT at distance (P<0.001 and near (P<0.001 compared with controls. There was no significant difference in mean divergence amplitudes between the two groups when testing using a synoptophore (P=0.53. In children with IXT, the distance between recovery point and break point in both convergence (distance: P=0.02; near: P=0.02 and divergence (distance: P<0.001; near: P<0.001 was larger than controls when detected by prism bar and synoptophore (convergence: P=0.005; divergence: P=0.006. Conclusions. Children with IXT have reduced convergence amplitudes as detected by both prism bar and synoptophore.

  11. DSM Generation from ALSO/PRISM Images Using SAT-PP

    Wolff, Kirsten; Gruen, Armin

    2008-11-01

    One of the most important products of ALOS/PRISM image data are accurate DSMs. To exploit the full potential of the full resolution of PRISM for DSM generation, a highly developed image matcher is needed. As a member of the validation and calibration team for PRISM we published earlier results of DSM generation using PRISM image triplets in combination with our software package SAT-PP. The overall accuracy across all object and image features for all tests lies between 1-5 pixels in matching, depending primarily on surface roughness, vegetation, image texture and image quality. Here we will discuss some new results. We focus on four different topics: the use of two different evaluation methods, the difference between a 5m and a 10m GSD for the final PRISM DSM, the influence of the level of initial information and the comparison of the quality of different combinations of the three different views forward, nadir and backward. All tests have been conducted with our testfield Bern/Thun, Switzerland.

  12. THREE-DIMENSIONAL IGNITION AND GROWTH REACTIVE FLOW MODELING OF PRISM FAILURE TESTS ON PBX 9502

    Garcia, M L; Tarver, C M

    2006-06-20

    The Ignition and Growth reactive flow model for shock initiation and detonation of solid explosives based on triaminotirnitrobenzene (TATB) is applied to three-dimensional detonation wave propagation. The most comprehensive set of three-dimensional detonation wave propagation data is that measured using the trapezoidal prism test. In this test, a PBX 9501 (95% HMX, 2.5% Estane, and 2.5% BDNPA/F) line detonator initiates a detonation wave along the trapezoidal face of a PBX 9502 (95% TATB and 5% Kel-F binder) prism. The failure thickness, which has been shown experimentally to be roughly half of the failure diameter of a long cylindrical charge, is measured after 50 mm of detonation wave propagation by impact with an aluminum witness plate. The effects of confinement impedance on the PBX 9502 failure thickness have been measured using air (unconfined), water, PMMA, magnesium, aluminum, lead, and copper placed in contact with the rectangular faces of the prism parallel to the direction of detonation propagation. These prism test results are modeled using the two-dimensional PBX 9502 Ignition and Growth model parameters determined by calculating failure diameter and tested on recent corner turning experiments. Good agreement between experimentally measured and calculated prism failure thicknesses for unconfined and confined PBX 9502 is reported.

  13. Investigation of beam steering performances in rotation Risley-prism scanner.

    Li, Anhu; Sun, Wansong; Yi, Wanli; Zuo, Qiyou

    2016-06-13

    Rotation Risley-prism scanner appears to be the most promising solution to high-accuracy beam scanning and target tracking. In the paper, some important issues crucial to the function implementation are thoroughly investigated. First the forming law of scan blind zone relative to double-prism structural parameters is explored by a quantitative analysis method. Then the nonlinear relationship between the rotation speeds of double prisms and the change rate of beam deviation angle is presented, and the beam scan singularity is indicated as an essential factor that confines the beam scan region. Finally, the high-accuracy radial scan theory is verified to illustrate the important application owing to the high reduction ratio from the rotation angles of double prisms to the deviation angles of the emergent beam. The research not only reveals the inner mechanisms of the Risley-prism beam scanning in principle, but also provide a foundation for the nonlinear control of various beam scan modes. PMID:27410303

  14. Beyond the sensorimotor plasticity: cognitive expansion of prism adaptation in healthy individuals.

    Carine eMICHEL

    2016-01-01

    Full Text Available Sensorimotor plasticity allows us to maintain an efficient motor behavior in reaction to environmental changes. One of the classical models for the study of sensorimotor plasticity is prism adaptation. It consists of pointing to visual targets while wearing prismatic lenses that shift the visual field laterally. The conditions of the development of the plasticity and the sensorimotor after-effects have been extensively studied for more than a century. However, the interest taken in this phenomenon was considerably increased since the demonstration of neglect rehabilitation following prism adaptation by Rossetti and his colleagues in 1998. Mirror effects, i.e. simulation of neglect in healthy individuals, were observed for the first time by Colent and collaborators in 2000. The present review focuses on the expansion of prism adaptation to cognitive functions in healthy individuals during the last 15 years. Cognitive after-effects have been shown in numerous tasks even in those that are not intrinsically spatial in nature. Altogether, these results suggest the existence of a strong link between low-level sensorimotor plasticity and high-level cognitive functions and raise important questions about the mechanisms involved in producing unexpected cognitive effects following prism adaptation. Implications for the functional mechanisms and neuroanatomical network of prism adaptation are discussed to explain how sensorimotor plasticity may affect cognitive processes.

  15. All-prism achromatic phase matching for tunable second-harmonic generation.

    Richman, B A; Bisson, S E; Trebino, R; Sidick, E; Jacobson, A

    1999-05-20

    Achromatic phase matching (APM) involves dispersing the light entering a nonlinear optical crystal so that a wide range of wavelengths is simultaneously phase matched. We constructed an APM apparatus consisting of six prisms, the final dispersion angle of which was optimized to match to second order in wavelength the type I phase-matching angle of beta barium borate (BBO). With this apparatus, we doubled tunable fundamental light from 620 to 700 nm in wavelength using a 4-mm-long BBO crystal. An analogous set of six prisms after the BBO crystal, optimized to second order in second-harmonic wavelength, realigned the output second-harmonic beams. Computer simulations predict that adjustment of a single prism can compensate angular misalignment of any or all the prisms before the crystal, and similarly for the prisms after the crystal. We demonstrated such compensation with the experimental device. The simulations also indicate that the phase-matching wavelength band can be shifted and optimized for different crystal lengths. PMID:18319927

  16. Accelerator system for the PRISM based muon to electron conversion experiment

    Alekou, A; Aslaninejad, M; Barlow, R J; Hock, R Chudzinski K M; Garland, J; Jenner, L J; Kelliher, D J; Kuno, Y; Kurup, A; Lagrange, J-B; Lancaster, M; Machida, S; Mori, Y; Muratori, B; Ohmori, C; Owen, H; Pasternak, J; Planche, T; Prior, C; Sato, A; Shi, Y; Smith, S; Uchida, Y; Witte, H; Yokoi, T; C13-07-29.2

    2013-01-01

    The next generation of lepton flavor violation experiments need high intensity and high quality muon beams. Production of such beams requires sending a short, high intensity proton pulse to the pion production target, capturing pions and collecting the resulting muons in the large acceptance transport system. The substantial increase of beam quality can be obtained by applying the RF phase rotation on the muon beam in the dedicated FFAG ring, which was proposed for the PRISM project.This allows to reduce the momentum spread of the beam and to purify from the unwanted components like pions or secondary protons. A PRISM Task Force is addressing the accelerator and detector issues that need to be solved in order to realize the PRISM experiment. The parameters of the required proton beam, the principles of the PRISM experiment and the baseline FFAG design are introduced. The spectrum of alternative designs for the PRISM FFAG ring are shown. Progress on ring main systems like injection and RF are presented. The cu...

  17. Digital Beam Steering Device Based on Decoupled Birefringent Prism Deflector and Polarization Rotator

    Pishnyak, Oleg; Kreminska, Lyubov; Laventovich, Oleg D.; Pouch, John J.; Miranda, Felix A.; Winker, Bruce K.

    2004-01-01

    We describe digital beam deflectors (DBDs) based on liquid crystals. Each stage of the device comprises a polarization rotator and a birefringent prism deflector. The birefringent prism deflects the beam by an angle that depends on polarization of the incident beam. The prism can be made of the uniaxial smectic A (SmA) liquid crystal (LC) or a solid crystal such as yttrium orthovanadate (YVO4). SmA prisms have high birefringence and can be constructed in a variety of shapes, including single prisms and prismatic blazed gratings of different angles and profiles. We address the challenges of uniform alignment of SmA, such as elimination of focal conic domains. Rotation of linear polarization is achieved by an electrically switched twisted nematic (TN) cell. A DBD composed of N rotator-deflector pairs steers the beam into 2(sup N) directions. As an example, we describe a four-stage DBD deflecting normally incident laser beam within the range of +/- 56 mrad with 8 mrad steps. Redirection of the beam is achieved by switching the TN cells.

  18. Prism-patterned Nafion membrane for enhanced water transport in polymer electrolyte membrane fuel cell

    Kim, Sang Moon; Kang, Yun Sik; Ahn, Chiyeong; Jang, Segeun; Kim, Minhyoung; Sung, Yung-Eun; Yoo, Sung Jong; Choi, Mansoo

    2016-06-01

    Here, we report a simple and effective strategy to enhance the performance of the polymer electrolyte membrane fuel cell by imprinting prism-patterned arrays onto the Nafion membrane, which provides three combined effects directly related to the device performance. First, a locally thinned membrane via imprinted micro prism-structures lead to reduced membrane resistance, which is confirmed by electrochemical impedance spectroscopy. Second, increments of the geometrical surface area of the prism-patterned Nafion membrane compared to a flat membrane result in the increase in the electrochemical active surface area. Third, the vertically asymmetric geometry of prism structures in the cathode catalyst layer lead to enhanced water transport, which is confirmed by oxygen gain calculation. To explain the enhanced water transport, we propose a simple theoretical model on removal of water droplets existing in the asymmetric catalyst layer. These three combined effects achieved via incorporating prism patterned arrays into the Nafion membrane effectively enhance the performance of the polymer electrolyte membrane fuel cell.

  19. 重度黄疸干扰Abbott CD1700血液分析仪白细胞测定的探讨

    黄小燕; 戴小波

    2006-01-01

    目的 探讨重度黄疸对Abbott CD1700全自动血液分析仪(简称CD1700)测定白细胞的影响和消除方法.方法 用CD1700和手工方法分别测定42例血清胆红素>150μmol/L的标本离心洗涤前后的白细胞总数和分类结果.结果 离心洗涤前CD1700对白细胞的测定结果与手工法测定差异有显著性(P<0.01);离心洗涤后CD1700对白细胞的测定结果与手工法差异无显著性(P>0.05).结论 重度黄疸(总胆红素>150μmol/L)对CD1700测定白细胞有很大干扰,离心洗涤可作为消除其干扰的有效方法.

  20. Laser Oscillator Incorporating a Wedged Polarization Rotator and a Porro Prism as Cavity Mirror

    Li, Steven

    2011-01-01

    A laser cavity was designed and implemented by using a wedged polarization rotator and a Porro prism in order to reduce the parts count, and to improve the laser reliability. In this invention, a z-cut quartz polarization rotator is used to compensate the wavelength retardance introduced by the Porro prism. The polarization rotator rotates the polarization of the linear polarized beam with a designed angle that is independent of the orientation of the rotator. This unique property was used to combine the retardance compensation and a Risley prism to a single optical component: a wedged polarization rotator. This greatly simplifies the laser alignment procedure and reduces the number of the laser optical components.

  1. Molten-salt Synthesis and Properties of ZnS with Hexagonal Prism Morphology

    LIU, Jin-Song; JI, Guang-Bin; LI, Zi-Quan; CAO, Jie-Ming; ZHENG, Ming-Bo; KE, Xing-Fei

    2007-01-01

    ZnS with hexagonal prism morphology has been synthesized successfully by molten-salt method with ZnS nanoparticles as precursors, and the ZnS nanoparticles were prepared by one-step solid-state reaction of Zn(CH3COO)2·2H2O with Na2S·9H2O at ambient temperature. Crystal structure and morphology of the product were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy and HRTEM. Ultraviolet-visible optical absorption spectrum of the ZnS hexagonal prism shows a distinct red shift from that of bulk ZnS crystals and photoluminescence spectrum exhibits strong emissions at 380 and 500 nm, respectively. Further experiments were designed and the formation mechanism of the ZnS hexagonal prism has been also discussed in brief.

  2. DNS of heat transfer in turbulent and transitional channel flow obstructed by rectangular prisms

    Direct numerical simulation (DNS) of heat transfer in a channel flow obstructed by rectangular prisms has been performed for Reτ = 80-20, where Reτ is based on the friction velocity, the channel half width and the kinematic viscosity. The molecular Prandtl number is set to be 0.71. The flow remains unsteady down to Reτ = 40 owing to the disturbance induced by the prism. For Reτ = 30 and 20, the flow results in a steady laminar flow. In the vicinity of the prism, the three-dimensional complex vortices are generated and heat transfer is enhanced. The Reynolds number effect on the time-averaged vortex structure and the local Nusselt number are investigated. The mechanism of the heat transfer enhancement is discussed. In addition, the mean flow parameters such as the friction factor and the Nusselt number are examined in comparison with existing DNS and experimental data

  3. Bragg prism monochromator and analyser for super ultra-small angle neutron scattering studies

    Apoorva G Wagh; Sohrab Abbas; Markus Strobl; Wolfgang Treimer

    2008-11-01

    We have designed, fabricated and operated a novel Bragg prism monochromator–analyser combination. With a judicious choice of the Bragg reflection, its asymmetry and the apex angle of the silicon single crystal prism, the monochromator has produced a neutron beam with sub-arcsec collimation. A Bragg prism analyser with the opposite asymmetry has been tailored to accept a still sharper angular profile. With this optimized monochromator–analyser pair, we have attained the narrowest and sharpest neutron angular profile to date. At this facility, we have recorded the first SUSANS spectra spanning wave vector transfers ∼ 10−6 Å-1 to characterize samples containing agglomerates up to tens of micrometres in size.

  4. On possibility of quality index increase for the prism mass analyzer

    In the work the possibilities of further growth of quality index (Q-value) in the prism mass-spectrometers with focusing by energy are found. In particularly, the achromatization in mass-analyzer could be reached at a peculiarly high Q value if the incoming unit consists of the decelerating collimator lense and several accelerating refracting faces with two-dimensional field are declining of the beam to the different sides. Q value in prism mass-analyzer increase additionally if the decelerating face with high angle enlargement adjoins to the object space. An increase of Q value in 4-5 times in comparison with symmetrical prism mass-analyzer of the same overall dimensions easily reaching already at existence in the incoming electrostatic unit the one refracting face both before the lense and after it, and in the output unit only focusing lenses

  5. Instantaneous flow field above the free end of finite-height cylinders and prisms

    Highlights: • PIV measurements of the flow above the free end of finite-height bodies. • Effect of cross-sectional shape of the models on the instantaneous flow. • Small-scale structures generated by the separated shear layer were revealed. • Effect of aspect ratio on the reattachment of the separated flow on the free end. -- Abstract: The flow above the free ends of surface-mounted finite-height circular cylinders and square prisms was studied experimentally using particle image velocimetry (PIV). Cylinders and prisms with aspect ratios of AR = 9, 7, 5, and 3 were tested at a Reynolds number of Re = 4.2 × 104. The bodies were mounted normal to a ground plane and were partially immersed in a turbulent zero-pressure-gradient boundary layer, where the boundary layer thickness relative to the body width was δ/D = 1.6. PIV measurements were made above the free ends of the bodies in a vertical plane aligned with the flow centreline. The present PIV results provide insight into the effects of aspect ratio and body shape on the instantaneous flow field. The recirculation zone under the separated shear layer is larger for the square prism of AR = 3 compared to the more slender prism of AR = 9. Also, for a square prism with low aspect ratio (AR = 3), the influence of the reverse flow over the free end surface becomes more significant compared to that for a higher aspect ratio (AR = 9). For the circular cylinder, a cross-stream vortex forms within the recirculation zone. As the aspect ratio of the cylinder decreases, the reattachment point of the separated flow on the free end surface moves closer to the trailing edge. For both the square prism and circular cylinder cases, the instantaneous velocity vector field and associated in-plane vorticity field revealed small-scale structures mostly generated by the separated shear layer

  6. A Novel Method for Heightening Sensitivity of Prism Coupler-Based SPR Sensor

    ZHANG Zhi-Wei; WEN Ting-Dun; WU Zhi-Fang

    2011-01-01

    We present a novel method for heightening the sensitivity of a prism coupler-based surface plasmon resonance (SPR) sensor. The method is based on the total reflection prism made of BK7 glass combined with the Kretschmann geometry of theattenuated total reflection (ATR) method. Compared to the conventional methods of prism coupler-based SPR the novel method provides higher semsitivity to the measurement system.Theoretical simulations show that the detetion sensitivity to the refractive index (RI) of the sensor based on the novel approach has a strong dependence on the thickness of the metal layer. The RI resolution of the sensor is predicted to be 8 × 107 refractive indox units (RIU) under the condition of optimum metal film thickness.This novel method can leave out a precision angle rotation device in the angle modulation and it is unnecessary to adjust the acceptance angle of the light detector. The principal advantage of this method over other methods of light intensity modulation based on prism coupler-based SPR is high sensitivity, expediency to measure and aplication of long distances.%@@ We present a novel method for heightening the sensitivity of a prism coupler-based surface plasmon resonance(SPR) sensor.The method is based on the total reflection prism made of BK7 glass combined with the Kretschmann geometry of theattenuated total reflection(ATR) method.Compared to the conventional methods of prism coupler-based SPR,the novel method provides higher sensitivity to the measurement system.Theoretical simulations show that the detection sensitivity to the refractive index(RI) of the sensor based on the novel approach has a strong dependence on the thickness of the metal layer.The RI resolution of the sensor is predicted to be 8 × 10-7 refractive index units(RIU) under the condition of optimum metal film thickness.This novel method can leave out a precision angle rotation device in the angle modulation and it is unnecessary to adjust the acceptance angle of

  7. Design of an Airborne Portable Remote Imaging Spectrometer (PRISM) for the Coastal Ocean

    Mouroulis, P.; vanGorp, B.; Green, R. O.; Cohen, D.; Wilson, D.; Randall, D.; Rodriguez, J.; Polanco, O.; Dierssen, H.; Balasubramanian, K.; Vargas, R.; Hein, R.; Sobel, H.; Eastwood, M.

    2010-01-01

    PRISM is a pushbroom imaging spectrometer currently under development at the Jet Propulsion Laboratory, intended to address the needs of airborne coastal ocean science research. We describe here the instrument design and the technologies that enable it to achieve its distinguishing characteristics. PRISM covers the 350-1050 nm range with a 3.1 nm sampling and a 33(deg) field of view. The design provides for high signal to noise ratio, high uniformity of response, and low polarization sensitivity. The complete instrument also incorporates two additional wavelength bands at 1240 and 1610 nm in a spot radiometer configuration to aid with atmospheric correction.

  8. Evaluation of the Performance of Routine Information System Management (PRISM framework: evidence from Uganda

    Aqil Anwer

    2010-07-01

    Full Text Available Abstract Background Sound policy, resource allocation and day-to-day management decisions in the health sector require timely information from routine health information systems (RHIS. In most low- and middle-income countries, the RHIS is viewed as being inadequate in providing quality data and continuous information that can be used to help improve health system performance. In addition, there is limited evidence on the effectiveness of RHIS strengthening interventions in improving data quality and use. The purpose of this study is to evaluate the usefulness of the newly developed Performance of Routine Information System Management (PRISM framework, which consists of a conceptual framework and associated data collection and analysis tools to assess, design, strengthen and evaluate RHIS. The specific objectives of the study are: a to assess the reliability and validity of the PRISM instruments and b to assess the validity of the PRISM conceptual framework. Methods Facility- and worker-level data were collected from 110 health care facilities in twelve districts in Uganda in 2004 and 2007 using records reviews, structured interviews and self-administered questionnaires. The analysis procedures include Cronbach's alpha to assess internal consistency of selected instruments, test-retest analysis to assess the reliability and sensitivity of the instruments, and bivariate and multivariate statistical techniques to assess validity of the PRISM instruments and conceptual framework. Results Cronbach's alpha analysis suggests high reliability (0.7 or greater for the indices measuring a promotion of a culture of information, RHIS tasks self-efficacy and motivation. The study results also suggest that a promotion of a culture of information influences RHIS tasks self-efficacy, RHIS tasks competence and motivation, and that self-efficacy and the presence of RHIS staff have a direct influence on the use of RHIS information, a key aspect of RHIS performance

  9. Optimization studies for the prism alternative oxide core, and its response to the actinide burning strategy

    The PRISM advanced liquid metal reactor is designed by General Electric in a reference solution equipped by a metal fuelled core. An alternative oxide core is studied by General Electric and ENEA in the frame of a collaboration existing since 1989. This paper deals with the ENEA contribution on the oxide solution, aimed at the core optimization both from safety parameters and fuel cycle economy points of view. Moreover, synthetic information about ENEA evaluations about the minor actinide burning capability of the PRISM oxide core are given. (author)

  10. Efficient broadband second-harmonic generation by dispersive achromatic nonlinear conversion using only prisms

    Richman, B.A.; Bisson, S.E.; Trebino, R.

    1997-12-01

    Using a lossless dispersive apparatus consisting of six prisms, optimized to match a second-harmonic crystal phase-matching angle vs. wavelength to second order, we efficiently doubled tunable fundamental light near 660 nm over a range of 80 nm using a 4-mm-long type-I {beta}-Barium Borate (BBO) crystal. Another lossless set of six prisms after the crystal realigned the propagation directions of the various second-harmonic frequencies to be collinear to within 1/4 spot diameter in position and 200 {mu}rad in angle. The measured conversion efficiency of a 40-mJ, 5-ns fundamental pulse was 10%.

  11. The building and simulation of color analytical model based on prism dispersion

    Yu, Xun; Li, Xiaoming; Wang, Yawei

    2015-02-01

    The color based on prism dispersion was analyzed and the mathematical model was established in this paper. Firstly, based on Dan Bruton's research, the mapping relationship between visible wavelength and data in color map matrix was created, the geometric data of color after dispersion of the prism was processed with least squares curve fitting, then the mapping relationship between wavelength and the refractive index was built. Secondly, on the basis of the work before, the mapping relationship between wavelength and projection geometry was built. Finally, through the building of color management system, the characterization of spectral lines and colors in LAB color space would be got.

  12. PRETVORBA 3D MODELOV IZ PROGRAMA BLENDER V BINARNI ZAPIS IGRALNEGA POGONA PRISM3D

    Lušenc, Simon

    2014-01-01

    Magistrsko delo predstavi binarni zapis 3D modelov, uporabljenih v igralnem pogonu Prism3D in razvoj dodatka za pretvorbo 3D modelov s programskim orodjem Blender, ki ga tudi najprej na kratko opišemo. V nadaljevanju analiziramo zapise uporabljenih datotek, kar nam omogoči razvoj dodatka za uvoz in izvoz 3D modela, uporabljenega v igralnem pogonu Prism3D. Po predstavljeni izdelavi dodatka z vizualno primerjavo ocenimo njegovo uspešnosti in podamo možne izboljšave.

  13. PRISM, a Novel Visual Metaphor Measuring Personally Salient Appraisals, Attitudes and Decision-Making: Qualitative Evidence Synthesis.

    Tom Sensky

    Full Text Available PRISM (the Pictorial Representation of Illness and Self Measure is a novel, simple visual instrument. Its utility was initially discovered serendipitously, but has been validated as a quantitative measure of suffering. Recently, new applications for different purposes, even in non-health settings, have encouraged further exploration of how PRISM works, and how it might be applied. This review will summarise the results to date from applications of PRISM and propose a generic conceptualisation of how PRISM works which is consistent with all these applications.A systematic review, in the form of a qualitative evidence synthesis, was carried out of all available published data on PRISM.Fifty-two publications were identified, with a total of 8254 participants. Facilitated by simple instructions, PRISM has been used with patient groups in a variety of settings and cultures. As a measure of suffering, PRISM has, with few exceptions, behaved as expected according to Eric Cassell's seminal conceptualisation of suffering. PRISM has also been used to assess beliefs about or attitudes to stressful working conditions, interpersonal relations, alcohol consumption, and suicide, amongst others.This review supports PRISM behaving as a visual metaphor of the relationship of objects (eg 'my illness' to a subject (eg 'myself' in a defined context (eg 'my life at the moment'. As a visual metaphor, it is quick to complete and yields personally salient information. PRISM is likely to have wide applications in assessing beliefs, attitudes, and decision-making, because of its properties, and because it yields both quantitative and qualitative data. In medicine, it can serve as a generic patient-reported outcome measure. It can serve as a tool for representational guidance, can be applied to developing strategies visually, and is likely to have applications in coaching, psychological assessment and therapeutic interventions.

  14. PRISM, a Novel Visual Metaphor Measuring Personally Salient Appraisals, Attitudes and Decision-Making: Qualitative Evidence Synthesis

    Sensky, Tom; Büchi, Stefan

    2016-01-01

    Background PRISM (the Pictorial Representation of Illness and Self Measure) is a novel, simple visual instrument. Its utility was initially discovered serendipitously, but has been validated as a quantitative measure of suffering. Recently, new applications for different purposes, even in non-health settings, have encouraged further exploration of how PRISM works, and how it might be applied. This review will summarise the results to date from applications of PRISM and propose a generic conceptualisation of how PRISM works which is consistent with all these applications. Methods A systematic review, in the form of a qualitative evidence synthesis, was carried out of all available published data on PRISM. Results Fifty-two publications were identified, with a total of 8254 participants. Facilitated by simple instructions, PRISM has been used with patient groups in a variety of settings and cultures. As a measure of suffering, PRISM has, with few exceptions, behaved as expected according to Eric Cassell’s seminal conceptualisation of suffering. PRISM has also been used to assess beliefs about or attitudes to stressful working conditions, interpersonal relations, alcohol consumption, and suicide, amongst others. Discussion This review supports PRISM behaving as a visual metaphor of the relationship of objects (eg ‘my illness’) to a subject (eg ‘myself’) in a defined context (eg ‘my life at the moment’). As a visual metaphor, it is quick to complete and yields personally salient information. PRISM is likely to have wide applications in assessing beliefs, attitudes, and decision-making, because of its properties, and because it yields both quantitative and qualitative data. In medicine, it can serve as a generic patient-reported outcome measure. It can serve as a tool for representational guidance, can be applied to developing strategies visually, and is likely to have applications in coaching, psychological assessment and therapeutic interventions. PMID

  15. Immune response elicited by an intranasally delivered HBsAg low-dose adsorbed to poly-ε-caprolactone based nanoparticles.

    Jesus, Sandra; Soares, Edna; Costa, João; Borchard, Gerrit; Borges, Olga

    2016-05-17

    Among new strategies to increase hepatitis B virus (HBV) vaccination, especially in developing countries, the development of self-administered vaccines is considered one of the most valuable. Nasal vaccination using polymeric nanoparticles (NPs) constitutes a valid approach to this issue. In detail, poly-ε-caprolactone (PCL)/chitosan NPs present advantages as a mucosal vaccine delivery system: the high resistance of PCL against degradation in biological fluids and the mucoadhesive and immunostimulatory properties of chitosan. In vitro studies revealed these NPs were retained in a mucus-secreting pulmonary epithelial cell line and were capable of entering into differentiated epithelial cells. The intranasal (IN) administration of 3 different doses of HBsAg (1.5μg, 5μg and 10μg) adsorbed on a fixed amount of PCL/chitosan NPs (1614μg) generated identical titers of serum anti-HBsAg IgG and anti-HBsAg sIgA in mice nasal secretions. Besides other factors, the NP surface characteristics, particularly, zeta potential differences among the administered formulations are believed to be implicated in the outcome of the immune response generated. PMID:26976502

  16. Effect of a polysaccharide from Poria cocos on humoral response in mice immunized by H1N1 influenza and HBsAg vaccines.

    Wu, Yajun; Li, Shuai; Li, Haixia; Zhao, Chunzhi; Ma, Hao; Zhao, Xiunan; Wu, Junhua; Liu, Kunlu; Shan, Junjie; Wang, Yuxia

    2016-10-01

    Poria cocos has a long history of medicinal use in China. Polysaccharides and their derivatives in the medicine exhibit many beneficial biological activities including anticancer, anti-inflammatory, antioxidant and antiviral activities. In this study, a new polysaccharide (PCP-II) was isolated from sclerotium of Poria cocos. Its physico-chemical characters were identified and its adjuvant activity was investigated in mice co-immunized with H1N1 influenza vaccine and hepatitis B surface antigen (HBsAg). The results revealed that PCP-II has a molecular weight of 29.0kDa. It was composed of fucose, mannose, glucose and galactose in molar ration of 1.00:1.63:0.16:6.29 respectively. Pharmacological data demonstrated that PCP-II increased antigen-specific antibody levels in mice immunized with influenza vaccine. PCP-II also elicited anti-HBsAg antibodies at significantly higher titers and generated robust and durable immunity compared to mice immunized with HBsAg-alum following two administrations. PCP-II improved proliferation of splenocytes, stimulated IL-12p70 and TNF-α productions in dendritic cells and macrophages respectively. These results suggested that PCP-II-adjuvanted vaccines enhanced humoral and cellular immunity. PCP-II could be developed as an efficacious adjuvant in human and animal vaccines. PMID:27185068

  17. Understanding University Reform in Japan through the Prism of the Social Sciences

    Goodman, Roger

    2008-01-01

    This article looks at current university reforms in Japan through two slightly different social science prisms: how social science methodologies and theories can help us understand those reforms better and how social science teaching in universities will be affected by the current reform processes. (Contains 3 tables and 7 notes.)

  18. Economic assessment of S-prism including development and generating costs

    S-PRISM is an advanced Fast Reactor plant design that utilizes compact modular pool-type reactors sized to enable factory fabrication and an affordable prototype test of a single Nuclear Steam Supply System (NSSS) for design certification at minimum cost and risk. S-PRISM retains all of the key ALMR (advanced liquid metal reactor) design features including passive reactor shutdown, passive shutdown heat removal, and passive reactor cavity cooling that were developed under an earlier DOE program. Key factors that make S-PRISM competitive include: 1) The use of passive safety systems that eliminate the need for diesel generators and hardened active heat sinks to assure that sufficient heat is removed from the core, reactor, and containment systems following design and beyond design basis events. 2) A seven point advantage in the plant capacity factor (93 versus 86%) over a single large plant. 3) A much shorter construction schedule (45%) made possible by a modular design that allows near parallel (sequenced) construction of three relatively small, simple factory fabricated NSSSs instead of one large complex NSSS. This paper describes the approach, methods, and results of an in-depth economic assessment of S-PRISM. The assessment found that the generation cost from an NOAK plant would be less than 3 cents/kW-hr and that a design certification could be obtained in less than 15 years at a cost of 2.1 billion dollars. (authors)

  19. Two-pass-internal second-harmonic generation using a prism coupler.

    Gonzalez, D. G.; Nieh, S. T. K.; Steier, W. H.

    1973-01-01

    A dispersive quartz prism is used to couple the total second harmonic generated in both directions by an internal cavity frequency doubler. The study shows that the dispersion of air and mirror reflection phase shifts can be compensated for by a slight nonphase match condition in the doubler.

  20. Tidal Prism Modeling of Phytoplankton and Nitrogen Concentrations in Narragansett Bay and its Sub-Embayments

    A tidal prism model was developed to calculate temporal changes in the spatially averaged concentration of three state variables: phytoplankton, dissolved inorganic nitrogen, and detritus. Our main objective was to develop a model to help us understand the causes of phytoplankton...

  1. Novel laterally pumped by prism laser configuration for compact solid-state lasers

    We propose a new laser configuration in which the pump radiation is coupled into the laser crystal through a prism. The laser medium is square shaped and the prism is attached on one of its lateral sides, near one of the crystal extremities. The diode-laser fiber end is placed close to the prism hypotenuse, the pump radiation is coupled into the laser crystal through the opposite surface of the prism and propagates into the crystal through total internal reflections. This laser geometry is simple to align and permits the realization of compact diode-pumped laser systems, as well as power scaling. A diode-pumped Nd:YAG laser yielding pulses of 2.1 mJ energy under a pump with pulses of 9.9 mJ is demonstrated. The laser slope efficiency is 0.22. Furthermore, this geometry enables one to obtain passively Q-switched lasers with the saturable absorber crystal placed between the resonator high-reflectivity mirror and the laser crystal. A Nd:YAG laser, passively Q-switched by a Cr4+:YAG crystal with initial transmission T0 = 0.90, delivering laser output with a pulsed energy of 93 μJ, a duration of 26 ns and a pump threshold of 1.9 mJ, is realized in order to prove the concept. (letter)

  2. COMET and PRISM - Search for Charged Lepton Flavor Violation with Muons

    The experiment (COMET) at J-PARC to search for a charged-lepton-flavor-violating process of muon to electron conversion in a muonic atom is described. Future prospects of an experiment (PRISM) with even higher sensitivity is mentioned. On-going R and D on a highly intense muon source (MuSIC) at Osaka University is presented.

  3. Measurement of separator contact forces in ball bearings using a derotation prism

    Nypan, L. J.

    1978-01-01

    A derotation prism was used to produce a stationary image of balls deflecting a portion of the separator. Ball to cage contact forces in a 110 mm bearing at speeds to 12,000 rpm were found to be 25 N (five lb) maximum. Inner race land contact force was found to vary up to 20 N (four lb).

  4. A Novel Method for Heightening Sensitivity of Prism Coupler-Based SPR Sensor

    We present a novel method for heightening the sensitivity of a prism coupler-based surface plasmon resonance (SPR) sensor. The method is based on the total reflection prism made of BK7 glass combined with the Kretschmann geometry of theattenuated total reflection (ATR) method. Compared to the conventional methods of prism coupler-based SPR, the novel method provides higher sensitivity to the measurement system. Theoretical simulations show that the detection sensitivity to the refractive index (RI) of the sensor based on the novel approach has a strong dependence on the thickness of the metal layer. The RI resolution of the sensor is predicted to be 8 × 10−7 refractive index units (RIU) under the condition of optimum metal film thickness. This novel method can leave out a precision angle rotation device in the angle modulation and it is unnecessary to adjust the acceptance angle of the light detector. The principal advantage of this method over other methods of light intensity modulation based on prism coupler-based SPR is high sensitivity, expediency to measure and application of long distances. (fundamental areas of phenomenology(including applications))

  5. Nonlinear attractor dynamics in the fundamental and extended prism adaptation paradigm

    Frank, T.D. [Center for the Ecological Study of Perception and Action, Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269 (United States)], E-mail: frank@uconn.edu; Blau, Julia J.C. [Center for the Ecological Study of Perception and Action, Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269 (United States); Turvey, M.T. [Center for the Ecological Study of Perception and Action, Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269 (United States); Haskins Laboratories, New Haven, CT 06510 (United States)

    2009-03-09

    Adaptation and re-adaptation processes are studied in terms of dynamic attractors that evolve and devolve. In doing so, a theoretical account is given for the fundamental observation that adaptation and re-adaptation processes do not exhibit one-trial learning. Moreover, the emergence of the latent aftereffect in the extended prism paradigm is addressed.

  6. COMET and PRISM - Search for Charged Lepton Flavor Violation with Muons

    Kuno, Yoshitaka [Department of Physics, Osaka University, Osaka, 560-0043 (Japan)

    2012-04-15

    The experiment (COMET) at J-PARC to search for a charged-lepton-flavor-violating process of muon to electron conversion in a muonic atom is described. Future prospects of an experiment (PRISM) with even higher sensitivity is mentioned. On-going R and D on a highly intense muon source (MuSIC) at Osaka University is presented.

  7. Inverse solutions for a Risley prism scanner with iterative refinement by a forward solution.

    Li, Anhu; Gao, Xinjian; Sun, Wansong; Yi, Wanli; Bian, Yongming; Liu, Hongzhan; Liu, Liren

    2015-11-20

    Risley prism scanners are increasingly used for laser beam steering due to their wide angular scanning range and high resolution. However, the inverse problem, which focuses on obtaining the required prisms' orientations for a given target position, has not been perfectly solved so far. The existing inverse solutions are not accurate or efficient enough for high-accuracy and real-time tracking. An iterative method that combines an approximate inverse solution with an iterative refinement by the forward solution is set forth in this paper. Two case studies indicate that the rotation motions of Risley prism pairs controlled by iterative solutions can slew the beam to create the desired tracking pattern quickly and accurately. Based on this method, a Risley prism scanner developed as a standard trajectory generator is implemented for the error measurement of a robotic manipulator in our experiments. The simulation and experimental results show that the inverse solution for one target point can be obtained within nine iterations for a prescribed tracking error threshold. PMID:26836567

  8. Nonlinear attractor dynamics in the fundamental and extended prism adaptation paradigm

    Adaptation and re-adaptation processes are studied in terms of dynamic attractors that evolve and devolve. In doing so, a theoretical account is given for the fundamental observation that adaptation and re-adaptation processes do not exhibit one-trial learning. Moreover, the emergence of the latent aftereffect in the extended prism paradigm is addressed

  9. Family Perspectives: Using a Cultural Prism to Understand Families from Asian Cultural Backgrounds

    Lee, Suk-Hyang; Turnbull, Ann P.; Zan, Fei

    2009-01-01

    Educators can better serve students who come from diverse cultural backgrounds by understanding the differing cultural values of these students and their families. This article explores different cultural perspectives using a cultural prism approach, focused most specifically on the Korean and Chinese cultures. (Contains 2 tables.)

  10. Development and application of GIS-based PRISM integration through a plugin approach

    Lee, Woo-Seop; Chun, Jong Ahn; Kang, Kwangmin

    2014-05-01

    A PRISM (Parameter-elevation Regressions on Independent Slopes Model) QGIS-plugin was developed on Quantum GIS platform in this study. This Quantum GIS plugin system provides user-friendly graphic user interfaces (GUIs) so that users can obtain gridded meteorological data of high resolutions (1 km × 1 km). Also, this software is designed to run on a personal computer so that it does not require an internet access or a sophisticated computer system. This module is a user-friendly system that a user can generate PRISM data with ease. The proposed PRISM QGIS-plugin is a hybrid statistical-geographic model system that uses coarse resolution datasets (APHRODITE datasets in this study) with digital elevation data to generate the fine-resolution gridded precipitation. To validate the performance of the software, Prek Thnot River Basin in Kandal, Cambodia is selected for application. Overall statistical analysis shows promising outputs generated by the proposed plugin. Error measures such as RMSE (Root Mean Square Error) and MAPE (Mean Absolute Percentage Error) were used to evaluate the performance of the developed PRISM QGIS-plugin. Evaluation results using RMSE and MAPE were 2.76 mm and 4.2%, respectively. This study suggested that the plugin can be used to generate high resolution precipitation datasets for hydrological and climatological studies at a watershed where observed weather datasets are limited.

  11. Active control of flow around a square prism by slot jet injection

    Hacıalioğulları M.

    2013-04-01

    Full Text Available The main aim of the experimental study is to determine both the most effective injection surface and rate in order to ensure minimum drag and fluctuating forces on a square prism subjected to crossflow. All predetermined jet injection surfaces i.e. front, side, and rear, tested separately for injection ratios of IR = 0, 1, 1.5, 2 at Reynolds number of Re = 16,000. Surface pressures were measured by differential pressure transducer whereas instantaneous velocity measurements were performed by using multichannel Constant Temperature Anemometer (CTA. It was concluded that jet injection, especially from the rear surface, brought noticeable improvements to the flow characteristics of a square prism. For rear jet configuration with IR = 1.5, the mean drag coefficient (CDT¯$overline {{C_{{m{DT}}}}} $ was reduced to 79.4% and CP RMS level on side surfaces was reduced to 20% of that of the single square prism. In addition, instantaneous flow visualization photographs and Strouhal number (St distribution across the injection ratio were also presented to identify the flow patterns and underlying mechanism of drag and fluctuating force reduction of square prism with rear jet configuration.

  12. On the Orchard crossing number of prisms, ladders and other related graphs

    Feder, Elie

    2011-01-01

    This paper deals with the Orchard crossing number of some families of graphs which are based on cycles. These include disjoint cycles, cycles which share a vertex and cycles which share an edge. Specifically, we focus on the prism and ladder graphs.

  13. Prioritization Risk Integration Simulation Model (PRISM) For Environmental Remediation and Waste Management - 12097

    The PRISM (Prioritization Risk Integration Simulation Model), a computer model was developed to support the Department of Energy's Office of Environmental Management (DOE-EM) in its mission to clean up the environmental legacy from the Nation's nuclear weapons materials production complex. PRISM provides a comprehensive, fully integrated planning tool that can tie together DOE-EM's projects. It is designed to help DOE managers develop sound, risk-informed business practices and defend program decisions. It provides a better ability to understand and manage programmatic risks. The underlying concept for PRISM is that DOE-EM 'owns' a portfolio of environmental legacy obligations (ELOs), and that its mission is to transform the ELOs from their current conditions to acceptable conditions, in the most effective way possible. There are many types of ELOs - - contaminated soils and groundwater plumes, disused facilities awaiting D and D, and various types of wastes waiting for processing or disposal. For a given suite of planned activities, PRISM simulates the outcomes as they play out over time, allowing for all key identified uncertainties and risk factors. Each contaminated building, land area and waste stream is tracked from cradle to grave, and all of the linkages affecting different waste streams are captured. The progression of the activities is fully dynamic, reflecting DOE-EM's prioritization approaches, precedence requirements, available funding, and the consequences of risks and uncertainties. The top level of PRISM is the end-user interface that allows rapid evaluation of alternative scenarios and viewing the results in a variety of useful ways. PRISM is a fully probabilistic model, allowing the user to specify uncertainties in input data (such as the magnitude of an existing groundwater plume, or the total cost to complete a planned activity) as well as specific risk events that might occur. PRISM is based on the GoldSim software that is widely used for risk

  14. Prevalence of HBsAg, knowledge, and vaccination practice against viral hepatitis B infection among doctors and nurses in a secondary health care facility in Lagos state, South-western Nigeria

    Abiola, Abdul-Hakeem Olatunji; Agunbiade, Adebukola Bola; Badmos, Kabir Bolarinwa; Lesi, Adenike Olufunmilayo; Lawal, Abdulrazzaq Oluwagbemiga; Alli, Quadri Olatunji

    2016-01-01

    Introduction Hepatitis B Virus, a highly infectious blood-borne virus poses a major threat to public health globally due to its high prevalence rate and grave consequence in causing liver cirrhosis and hepatocelullar carcinoma, the third cause of cancer death worldwide. The aim is determine the prevalence of HBsAg, knowledge, and vaccination practices against viral hepatitis B infection among doctors and nurses in a health care facility. Methods Study design was a descriptive cross-sectional ...

  15. Preapplication safety evaluation report for the Power Reactor Innovative Small Module (PRISM) liquid-metal reactor

    This preapplication safety evaluation report (PSER) presents the results of the preapplication desip review for die Power Reactor Innovative Small Module (PRISM) liquid-mew (sodium)-cooled reactor, Nuclear Regulatory Commission (NRC) Project No. 674. The PRISM conceptual desip was submitted by the US Department of Energy in accordance with the NRC's ''Statement of Policy for the Regulation of Advanced Nuclear Power Plants'' (51 Federal Register 24643). This policy provides for the early Commission review and interaction with designers and licensees. The PRISM reactor desip is a small, modular, pool-type, liquid-mew (sodium)-cooled reactor. The standard plant design consists of dim identical power blocks with a total electrical output rating of 1395 MWe- Each power block comprises three reactor modules, each with a thermal rating of 471 MWt. Each module is located in its own below-grade silo and is co to its own intermediate heat transport system and steam generator system. The reactors utilize a metallic-type fuel, a ternary alloy of U-Pu-Zr. The design includes passive reactor shutdown and passive decay heat removal features. The PSER is the NRC's preliminary evaluation of the safety features in the PRISM design, including the projected research and development programs required to support the design and the proposed testing needs. Because the NRC review was based on a conceptual design, the PSER did not result in an approval of the design. Instead it identified certain key safety issues, provided some guidance on applicable licensing criteria, assessed the adequacy of the preapplicant's research and development programs, and concluded that no obvious impediments to licensing the PRISM design had been identified

  16. Illusory reversal of causality between touch and vision has no effect on prism adaptation rate

    HirokazuTanaka

    2012-12-01

    Full Text Available Learning, according to Oxford Dictionary, is “to gain knowledge or skill by studying, from experience, from being taught, etc.” In order to learn from experience, the central nervous system has to decide what action leads to what consequence, and temporal perception plays a critical role in determining the causality between actions and consequences. In motor adaptation, causality between action and consequence is implicitly assumed so that a subject adapts to a new environment based on the consequence caused by her action. Adaptation to visual displacement induced by prisms is a prime example; the visual error signal associated with the motor output contributes to the recovery of accurate reaching, and a delayed feedback of visual error can decrease the adaptation rate. Subjective feeling of temporal order of action and consequence, however, can be modified or even reversed when her sense of simultaneity is manipulated with an artificially delayed feedback. Our previous study (Tanaka, Homma & Imamizu (2011 Exp Brain Res demonstrated that the rate of prism adaptation was unaffected when the subjective delay of visual feedback was shortened. This study asked whether subjects could adapt to prism adaptation and whether the rate of prism adaptation was affected when the subjective temporal order was illusory reversed. Adapting to additional 100 ms delay and its sudden removal caused a positive shift of point of simultaneity in a temporal-order judgment experiment, indicating an illusory reversal of action and consequence. We found that, even in this case, the subjects were able to adapt to prism displacement with the learning rate that was statistically indistinguishable to that without temporal adaptation. This result provides further evidence to the dissociation between conscious temporal perception and motor adaptation.

  17. Testing the PRISM Temperature Model in Complex Terrain: Implications for Mountain Ecohydrology

    Strachan, S.; Daly, C.; Millar, C.

    2015-12-01

    Studies in mountainous terrain related to ecology and hydrology often use interpolated climate products because of a lack of local observations. One dataset frequently used to develop plot-to-watershed scale climatologies is the PRISM (Parameter-elevation Regression on Independent Slopes Model) temperature model. Benefits of this approach include geographically-weighted station observations and topographic positioning modifiers, which become important factors for predicting temperature in complex topography. Because of the paucity of long-term climate records in mountain environments, validation of PRISM algorithms across diverse regions remains challenging, with end users instead relying on atmospheric relationships derived in sometimes distant geographic settings. Recent developments of the PRISM model have increased temporal resolution capability from monthly to daily, which in turn has allowed a reasonable test of PRISM performance during a single season at distributed points across a large watershed. Presented are results from testing instrumental observations of daily max/min temperature on 16 sites in the Walker Basin, CA-NV, located on open woodland slopes ranging from 1967 to 3111 m in elevation. Individual site MAE varies from 1.34 to 4.22 C with better performance observed during summertime as opposed to winter. We observe a consistent bias in minimum temperatures for all seasons across all sites, with bias in maximum temperatures varying with season. Model error for minimum is associated strongly with elevation, whereas model error for maximum is associated with topographic radiative indices (solar exposure and heat loading). These results indicate that actual temperature conditions across open mountain woodland slopes are more heterogeneous than interpolated models (such as PRISM) indicate, which in turn impacts prediction/modeling of landscape processes such as ecological niches, bioclimatic refugia, and snow hydrology.

  18. Design considerations for an unconventional infrared prism with a 90-degree ray deviation

    Akarca, Beyza; Artan, Göktuǧ G.

    2015-09-01

    In this study, the optical performance of a 90 degree prism working in the mid-wave infrared region with the purpose of carrying a beam of light from one optical system to another in an unconventional way is discussed. First, a group of mirrors is considered as a design alternative to lower the overall cost of the system. However, using mirrors greatly increases the diameter of the beam due to the rays coming from wide field of view angles. Another drawback of mirrors is that having separate mirrors requires precise alignment for the system to work at full performance which is difficult for the given application. However, these alignment issues are not valid for a single piece prism. Therefore, a single piece prism is the preferred option and has been taken into account in this study. Material selection is important, especially in the mid-wave infrared region where the index of refraction differs greatly from material to material. Silicon and Germanium are the materials preferred because of their high index of refraction and transmission characteristics. Aside from optical properties, these materials are also considered in terms of manufacturability. Also, options for the coatings to be applied to reflecting surfaces of the prism are discussed with regard to the transmission loss within the system. In order to have total internal reflection within a prism, coatings must be chosen carefully to handle transmission loss at the reflecting surfaces. All of the system parameters are examined using sequential and non-sequential modes of ZEMAX OpticStudio software.

  19. The Personalized Reminder Information and Social Management System (PRISM) Trial: Rationale, Methods and Baseline Characteristics

    Czaja, Sara J.; Boot, Walter R.; Charness, Neil; Rogers, Wendy; Sharit, Joseph; Fisk, Arthur D.; Lee, Chin Chin; Nair, Sankaran N.

    2014-01-01

    Technology holds promise in terms of providing support to older adults. To date there have been limited robust systematic efforts to evaluate the psychosocial benefits of technology for older people and identify factors that influence both the usability and uptake of technology systems. In response to these issues we developed the Personal Reminder Information and Social Management System (PRISM), a software application designed for older adults to support social connectivity, memory, knowledge about topics, leisure activities and access to resources. This trail is evaluating the impact of access to the PRISM system on outcomes such as social isolation, social support and connectivity. This paper reports on the approach used to design the PRISM system, study design, methodology and baseline data for the trial. The trial is multi-site randomized field trial. PRISM is being compared to a Binder condition where participants received a binder that contained content similar to that found on PRISM. The sample includes 300 older adults, aged 65 – 98 years, who lived alone and at risk for being isolated. The primary outcome measures for the trial include indices of social isolation and support and well-being. Secondary outcomes measures include indices of computer proficiency, technology uptake and attitudes towards technology. Follow-up assessments occurred at 6 and 12 months post-randomization. The results of this study will yield important information about the potential value of technology for older adults. The study also demonstrates how a user-centered iterative design approach can be incorporated into the design and evaluation of an intervention protocol. PMID:25460342

  20. Comparison of the Abbott m2000 RealTime CT Assay and the Cepheid GeneXpert CT/NG Assay to the Roche Amplicor CT Assay for Detection of Chlamydia trachomatis in Ocular Samples from Tanzania

    Dize, Laura; West, Sheila; Williams, James A; Van Der Pol, Barbara; Quinn, Thomas C.; Gaydos, Charlotte A.

    2013-01-01

    The GeneXpert CT/NG assay (GeneXpert) and the Abbott m2000 RealTime CT (m2000) assay were compared to Amplicor for detecting ocular Chlamydia trachomatis. Discordant specimens were tested by the Aptima CT assay. The m2000 assay sensitivity was 100% (95% confidence interval [CI], 90% to 100%), and specificity was 98.46% (95% CI, 95.2% to 99.2%); GeneXpert sensitivity was 100% (95% CI, 90% to 100%), and specificity was 100% (95% CI, 98.1% to 100%). The m2000 and GeneXpert assays appear to perfo...

  1. Comparative evaluation of the Abbott RealTime High Risk HPV test and INNO-LiPA HPV Genotyping Extra test for detecting and identifying human papillomaviruses in archival tissue specimens of head and neck cancers:

    Gale, Nina; Hošnjak, Lea; Kocjan, Boštjan; Maver Vodičar, Polona; Odar, Katarina; Poljak, Mario; Zidar, Nina

    2012-01-01

    Introduction: The Abbott RealTime is a novel real-time PCR assay designed for concurrent individual genotyping of HPV16 and HPV18 and pooled detection of 12 HPV genotypes: HPV31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 in cervical swab specimens. In this study, the performance of RealTime for detecting HPV in formalin-fixed, paraffin-embedded tissue specimens of head and neck cancers was compared to the Innogenetics INNO-LiPA assay, which allows identification of 28 HPVs, including all...

  2. Detection of Chlamydia trachomatis and Neisseria gonorrhoeae in Rectal and Oropharyngeal Swabs and Urine Specimens from Men Who Have Sex With Men with Abbott's M2000 RealTime.

    Moncada, Jeanne; Shayevich, Clara; Philip, Susan S; Lucic, Danijela; Schachter, Julius

    2015-11-01

    We evaluated Abbott's RealTime assay for the detection of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) in the urethra, oropharynx, and rectum of 260 men who have sex with men. Compared with Hologic's AC2, RealTime had good agreement for detecting CT and GC. Overall, there were 25 CT and 44 GC AC2 positives, and 26 CT and 38 GC RealTime positives. For total negatives, there were 742 CT and 725 GC for AC2, 744 CT and 724 GC for RealTime. PMID:26457488

  3. Synthesis of hexagonal wurtzite Cu2ZnSnS4 prisms by an ultrasound-assisted microwave solvothermal method

    Wurtzite Cu2ZnSnS4 (CZTS) hexagonal prisms were synthesized by a simple ultrasound-microwave solvothermal method. The product was characterized by XRD, FESEM, EDS, TEM, Raman and UV–vis spectrometer. The hexagonal prisms were 0.5–2 μm wide and 5–12 μm long. The PVP played an important role in the formation of the CZTS hexagonal prisms. In addition, the ultrasound-assisted microwave process was helpful for synthesis of wurtzite rather than kesterite phase CZTS. A nucleation–dissolution–recrystallization mechanism was also proposed to explain the growth of the CZTS hexagonal prisms. - Graphical abstract: Wurtzite Cu2ZnSnS4 hexagonal prisms were synthesized by ultrasound-microwave solvothermal method. The ultrasound-assisted microwave process and PVP were useful to the growth of CZTS. A nucleation–dissolution–recrystallization growth mechanism was also proposed. - Highlights: • Wurtzite Cu2ZnSnS4 was prepared by ultrasound-assisted microwave solvothermal method. • The wurtzite CZTS hexagonal prisms are demonstrated a band gap of 1.49 eV. • Synergistic effect of ultrasound and microwave is helpful to prepare Wurtzite CZTS. • PVP plays an important role in the formation of the CZTS hexagonal prisms. • Nucleation–dissolution–recrystallization growth mechanism of the CZTS was proposed

  4. Eu3+-doped Y2O3 hexagonal prisms: Shape-controlled synthesis and tailored luminescence properties

    In this work, Eu3+ doped Y2O3 hexagonal prisms were synthesized by a novel two-phase approach, which involves water at the bottom as aqueous phase and oleylamine in the above as oil phase. With this unique reaction system, precursors of hexagonal prisms Y4O(OH)9(NO3) were first obtained by simply varying the volume ratio of water to oleylamine. Time-dependent experiments were systematically performed to reveal the growth mechanism of the precursor. After subsequent heat treatment, these precursors transformed to Y2O3 hexagonal prisms with controlled diameters and aspect ratios varying from 4 to 19. Such a transformation is preceded via a topotactic process, as indicated by TG-DTA and mass spectra. Eventually, all Eu3+ doped Y2O3 hexagonal prisms were found to exhibit an intensive red emission at 611 nm, which corresponds to 5D0→7F2 transition of Eu3+. With varying the aspect ratio of hexagonal prisms and increasing Eu3+ concentration in Y2O3, an optimum external quantum efficiency was achieved. - Graphical abstract: In this work, Eu3+ doped Y2O3 hexagonal prisms with controlled aspect ratio from 4.4 to 19.3 were synthesized by transformation of the precursor Y4O(OH)9(NO3) hexagonal prisms from a novel two-phase reaction system. The growth mechanism of the precursor has been systematically investigated, and a topotactic phase transformation from precursors to cubic Y2O3 is for the first time put forward. By the size controlling and aspect ratio adjusting, the luminescence emission intensity as well as external quantum efficiency of Eu3+ doped Y2O3 hexagonal prisms is further tailored to show an optimum. - Highlights: • Eu3+ doped Y2O3 hexagonal prisms were synthesized by a novel two-phase approach. • Inheriting mechanism of prisms morphology from Y4O(OH)9(NO3) to Y2O3 was discussed. • Aspect ratio of prisms was tailored by the volume ratio of water to oleylamine. • Luminescence properties were optimized by adjusting aspect ratio of prisms

  5. Prism stacking faults observed contiguous to a {10-12} twin in a Mg–Y alloy

    Using transmission electron microscopy, we document, for the first time, the presence of stacking faults on the (10-10) prism planes in a fine-grained Mg–Y alloy. These prism stacking faults were found to be exclusively contiguous to a {10-12} deformation twin. In addition, the {10-12} twin contained a high density of basal plane stacking faults. Arguments are developed for the interrelationship between the stacking faults on the prism planes in the matrix and those on the basal planes in the twin

  6. A poly(dimethylsiloxane) based prism for surface plasmon resonance imaging system and its application for gas detection

    Zhang, L. L.; Chen, X.; Sun, J. H.; Cai, H. Y.; Li, H.; Chao, Y. P.; Cui, D. F.

    2013-03-01

    This paper presents a surface plasmon resonance (SPR) imaging system based on a low-cost, convenient poly(dimethylsiloxane) (PDMS) prism featured with a close contact with the gold film. Compared to conventional glass prism, both numerical simulations and experimental studies indicated a deeper but wider absorption peak with a higher coupling angle for the PDMS based prism. System repeatability was quantified by the cycled detection of helium and air, with the effect of the flow rate investigated. Furthermore, five types of gases (nitrogen, air, oxygen, hydrogen, and helium) were detected and differentiated by the SPR system, with a calculated sensitivity of 5 × 10-6 RIU.

  7. Performance of the fully automated progesterone assays on the Abbott AxSYM and the Technicon Immuno 1 Analyser compared with the radioimmunoassay progesterone MAIA

    Test performance of two automated progesterone assays available on the immunoassay analysers Abbott AxSYM and Technicon Immuno 1, respectively, was evaluated in comparison with the radioimmunoassay Progesterone MAIA. For assessment of test performance imprecision, functional sensitivity and linearity of dilution was examined. Correlation with the manual radioimmunoassay was assessed using 122 serum samples over the range 0-110 nmol/L. Imprecision studies revealed for the AxSYM Progesterone within-run CV's of 1.8-6.4% and day-to-day CV's of 3.5-9.7% (concentration range 2.3-75 nmol/L); Immuno 1 Progesterone: within-run CV's 1.0-7.3%, day-to-day CV's 2.3-7.7% (concentration range 1.2-60 nmol/L). The functional sensitivity was <1.7 nmol/L for the AxSYM Progesterone and <1.1 nmol/L for the Immuno 1 Progesterone. With the AxSYM Progesterone the mean recovery after dilution from five samples was 102% (89-107%), from one sample only 69-80% was recovered; with the Immuno 1 Progesterone the mean recovery was 95% (80-105%). Despite of a quite good overall correlation (coefficients 0.972 and 0.981) the relationship of both assays to the Progesterone MAIA significantly deviate from linearity with a considerably higher slope within the lower concentration range. The relationship between the automated assays was linear over the entire concentration range (Immuno = 1.207 * AxSYM + 1; r = 0.986). The time to first result was 20 min for the AxSYM Progesterone, 45 min for the Immuno 1 Progesterone and 90 min for the Progesterone MAIA. The evaluated progesterone assays both exhibit an excellent precision and a high degree of sensitivity. They offer a rapid and flexible method for progesterone determination which may be especially useful for the monitoring of ovarian stimulation during in-vitro fertilization. (author)

  8. Thermo-optic Imbert-Fedorov effect in a prism-waveguide coupling system with silicon-on-insulator

    Tang, Tingting; Li, Chaoyang; Luo, Li; Zhang, Yanfen; Yuan, Quan

    2016-07-01

    In this paper, a prism-waveguide coupling system based on silicon-on-insulator (SOI) is revisited. We find that thermo-optic Imbert-Fedorov (TOIF) effect displays in this four-layer optical system which has not been proposed before. Furthermore, we discuss the TOIF shifts in prism/SiO2/Si/SiO2 and prism/Au/Si/SiO2 waveguides with different parameters and study the observed phenomena from physical point of view. It is shown that the maximum IF shift can achieve 140 μm in a prism/Au/Si/SiO2 waveguide which is large enough to be directly measured by the calculation results. Accordingly, TOIF shift provides a temperature control method for the enhancement and modulation of IF shift.

  9. Digital spatial wavelength domain multiplexing (DSWDM) using a prism-grating-prism (PGP) and a CMOS imager: implementation and initial testing

    Christiansen, Martin B.; Chen, Steve; Baldwin, Christopher S.; Niemczuk, John B.; Kiddy, Jason S.; Chen, Peter C.; Kopola, Harri K.; Aikio, Mauri; Suopajarvi, Pekka; Buckley, Steven G.

    2001-08-01

    A CMOS imager-based spectrometer is used to interrogate a network containing a large number of Bragg grating sensors on multiple fibers as part of a proprietary structural health monitoring system. The spectrometer uses a Prism-Grating-Prism (PGP) to spectrally separate serially multiplexed Bragg reflections on a single fiber. As a result, each Bragg grating produces a discrete spot on the CMOS imager that shifts horizontally as the Bragg grating experiences changes in strain or temperature. The reflected wavelength of the Bragg grating can be determined by finding the center of the spot produced. The use of a random addressing CMOS imager enables a flexible sampling rate. Some fibers can be interrogated at a high sampling rate while others can be interrogated at a lower sampling rate. However, the use of a CMOS camera brings several specific problems in terms of signal processing. These include a logarithmic pixel response, a low signal-to-noise ratio, the long pixel time constant, obtaining sufficient process priority for the control program, and proper selection of the window of interest. In this paper we investigate computer algorithms and hardware solutions to address these problems. We also present experimental data to validate these solutions including calibration data and initial field-testing data with 24 sensors on 4 fibers.

  10. Efficient broadband second-harmonic generation by dispersive achromatic nonlinear conversion using only prisms

    Using a lossless dispersive apparatus consisting of six prisms, optimized to match a second-harmonic crystal phase-matching angle versus wavelength to second order, we efficiently doubled tunable fundamental light near 660nm over a range of 80nm, using a 4-mm-long type I β-barium borate crystal without tuning the crystal angle. Another set of six prisms after the crystal realigned the propagation directions of the various second-harmonic frequencies to be collinear to within 1/4 spot diameter in position and 200 μrad in angle. The measured conversion efficiency of a 40-mJ, 5-ns fundamental pulse was 10%. copyright 1998 Optical Society of America

  11. A beam separator of a close packed prism array for low energy electron microscopy

    The electron optical properties of a beam separator made of a ''Chicane'' type close packed prism array proposed by Kolarik et al. [Optik 87 (1991) 1] have been analyzed. The total deflection angle of the illumination beam is 90 and that of the image forming beam is 0 . The second order aberrations are estimated using the eikonal method developed by Rose [Optik 51 (1978) 15] under the SCOFF approximation. It has a limitation in the analysis of the close packed prism array, because of the overlapped fringing field distributions. The magnetic field distributions of the separator are numerically calculated using the three dimensional finite difference method followed by direct ray tracing. The angles of the edge were readjusted by trial and error to get the stigmatic focus of the beam. (orig.)

  12. The Refractive Index Measurement Of Silicon Dioxide Thin Film by the Coupling Prism Method

    Refractive index of silicon dioxide thin film that doped with phosphor (SiO2:P) above the pure silicon dioxide substrate has been measured by light coupling prism method. The method principle is focusing the light on coupling prism base so that the light propagates into the waveguide layer while the reflected one forms a mode in the observation plane. The SiO2 thin film as waveguide layer has a refractive index that give the thick and refractive index relation. The He-Ne laser as light source has the wavelength λ 0,6328 μm. The refractive index measurement of the thin film with the substrate refractive index nsb = 1,47 and the thin film thick d = 2μm gives ng = 1,5534 ± 0,01136. This method can distinguish the refractive index of thin film about 6% to the refractive index of substrate

  13. Prism dispersion effects in near-guided-wave surface plasmon resonance sensors

    Refractive index dispersion causes the light line to curve. As a result it is shown that when the prism is dispersive, an additional dip in the spectral response of Surface Plasmon Resonance (SPR) sensors is observed in the Kretschmann-Raether (KR) configuration. Since the new dip evolves in the infrared (IR) region, it exhibits a high sensitivity to the analyte refractive index (RI) changes and the mode penetrates deeper into the analyte. Adding a thin dielectric layer with high refractive index on top of the metallic layer enables to control the dip location and strength. The two dips shift in opposite directions as the analyte RI changes and therefore when the spectral difference is considered as the measurand, higher RI sensitivity is obtained. The dispersion relation of two thin films bounded by two semi-infinite media is derived when the prism dispersion is considered. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  14. Dispersive radio frequency electrometry using Rydberg atoms in a prism-shaped atomic vapor cell

    Fan, H. Q.; Kumar, S.; Kübler, H.; Shaffer, J. P.

    2016-05-01

    We introduce a method to measure radio frequency (RF) electric fields (E-fields) using atoms contained in a prism-shaped vapor cell. The method utilizes the concept of electromagnetically induced transparency with Rydberg atoms. The RF E-field induces changes in the index of refraction of the vapor resulting in deflection of the probe laser beam as it passes through the prism-shaped vapor cell. We measured a minimum RF E-field of 8.25 μ {{Vcm}}-1 with a sensitivity of ∼ 46.5 μ {{Vcm}}-1 {{Hz}}-1/2. The experimental results agree with a numerical model that includes dephasing effects. We discuss possible improvements to obtain higher sensitivity for RF E-field measurements.

  15. Hard X-ray Holographic Microscopy using Refractive Prism and Fresnel Zone Plate Objective

    Imaging holography in hard x-ray region is realized by combining imaging microscopy with a refractive prism interferometer. The prism is placed behind the back-focal-plane of objective lens in order to configure a wave-front-division interferometer, and a magnified interferogram of object image is generated at an image plane. Spatial resolution of the image hologram is essentially determined by the performance of objective lens. However, speckle noise is a serious problem for fully coherent illumination. We have tried 'asymmetric spatial coherence' to reduce the speckle noise. A synchrotron radiation light source with small coupling constant is very suitable for this purpose. The spatial coherence is sufficiently high in the vertical direction to make an interferogram, and low enough in the horizontal direction to suppress the speckle noise. Preliminary experiments at BL20XU of SPring-8 are shown

  16. Moving forward with prisms: Sensory-motor adaptation improves gait initiation in Parkinson’s disease.

    Janet Helen Bultitude

    2012-09-01

    Full Text Available It is postulated that the decreased walking speed; small, shuffling steps; and ‘freezing’ shown by patients with Parkinson’s disease could stem from an inability to tilt the body forward enough to provide sufficient forward propulsion. In two repeated-measures studies we examined whether adaptation to upward-shifting prisms, resulting in a downward after-effect, could improve gait initiation in healthy participants and patients with Parkinson’s disease. Faster forward stepping followed a brief (5 min exposure period for patients, and a longer (20 min exposure period for age-matched controls. Backward stepping was unchanged, and adaptation to downward-shifting prisms with control participants showed no effect on forward or backward stepping. These results suggest that adaptation of arm proprioception in the vertical plane may generalise to anterior-posterior postural control, presenting new possibilities for the treatment of gait disturbance in basal ganglia disorders.

  17. Experimental Evaluation of Lightweight AAC Masonry Wall Prisms with Ferrocement Layers in Compression and Flexure

    Abdel Mooty, Mohamed

    2012-05-01

    An experimental program is designed to evaluate the performance of lightweight autoclaved aerated concrete masonry wall strengthened using ferrocement layers, in a sandwich structure, under in-plane compression and out-of-plane bending. The 25 mm thick ferrocement mortar is reinforced with steel welded wire mesh of 1 mm diameters at 15 mm spacing. Different types of shear connectors are used to evaluate their effect on failure loads. The effect of different design parameters on the wall strength are considered including wall thickness, mortar strength, and type and distribution of shear connectors. A total of 20 prisms are tested in compression and 5 prisms are tested under bending. The proposed ferrocement strengthening technique is easy to apply on existing wall system and results in significant strength and stiffness enhancement of the tested wall specimens. © (2012) Trans Tech Publications.

  18. A scalable expressive ensemble learning using Random Prism: a MapReduce approach

    Stahl, Frederic; May, David; Mills, Hugo; Bramer, Max; Gaber, Mohamed Medhat

    2015-01-01

    The induction of classification rules from previously unseen examples is one of the most important data mining tasks in science as well as commercial applications. In order to reduce the influence of noise in the data, ensemble learners are often applied. However, most ensemble learners are based on decision tree classifiers which are affected by noise. The Random Prism classifier has recently been proposed as an alternative to the popular Random Forests classifier, which is based on decision...

  19. Improvement of Mental Imagery after Prism Exposure in Neglect: A Case Study

    Gilles Rode; Yves Rossetti; Ling Li; Dominique Boisson

    1999-01-01

    Previous work has shown that various symptoms of unilateral neglect, including the pathological shift of the subjective midline to the right, may be improved by a short adaptation period to a prismatic shift of the visual field to the right. We report here the improvement of imagined neglect after prism exposure in a patient with a left unilateral neglect. Despite a strong neglect observed for mental images as well as for conventional tests, the mental evocation of left-sided information from...

  20. What controls landward vergence of the accretionary prism offshore northern Sumatra?

    Frederik, M. C. G.; Gulick, S. P. S.; Austin, J. A., Jr.; Bangs, N. L.; Udrekh, U.

    2014-12-01

    The accretionary prism offshore northern Sumatra consists of steep outer slopes (5-12°), and a plateau ~100-120 km wide comprised of anticlinal folds of 2-16 km wavelength seaward of a steep slope adjacent to the Aceh (forearc) Basin. Our study area, 1-7°N and 92-97°E, covers the entire forearc from northwest of Aceh to west of Simeulue Island. Five 2D MCS seismic profiles transecting the prism from the Sunda Trench to the Aceh Basin, along with multibeam data, have been used to investigate wedge morphology and structure. Analysis of fold vergence along the profiles and areal classification of the predominant vergence reveal three structural zones: 1) predominantly landward-vergent folds near the Sunda Trench, 2) predominantly seaward-vergent folds near the Aceh Basin, and 3) mixed vergent folds between those two zones. Extensive landward vergence is uncommon in accretionary prisms worldwide. One explanation is the existence of a backstop with a seaward dipping edge, such that overlying younger sediments accreted to the prism form landward-vergent folds. We propose a backstop geometry that extends from under the Aceh Basin to under the mixed vergence zone, based on the observed structural zones and published velocity models of this margin. The backstop may consist either of older accreted sediment or the granitic Sunda Block. With the existence of a strong inner wedge acting as a backstop, together with suspected indurated sediments forming the landward vergence zone, rupture during major subduction zone earthquakes nucleating under the forearc basin or central plateau high can propagate farther seaward toward the Sunda Trench and displace greater volumes of water than a more landward rupture, yielding more hazardous tsunami. Using bathymetric data of before and after the 2004 earthquake, we are now testing the hypothesis that maximum slip occurs near the trench. These results will be presented.

  1. PRISM [Power Reactor Inherently Safe Module] design concept enhances waste management

    PRISM, a modular advanced liquid metal reactor (ALMR), has been designed conceptually by GE under the US Department of Energy sponsorship. The concept design and analyses have been primarily focused on passive safety and improved construction and operating costs. Significantly, the unique design of multiple modules and features of PRISM enhance waste management over conventional reactor systems. This paper provides an overview of PRISM of these enhancements. Inherent to the ALMR's, the sodium coolant precludes crud buildup on reactor surfaces and in components and waste for disposal. Preliminary evaluations indicate this fundamental feature results in factors of 2-4 less waste volume and 2-3 orders of magnitude less curies per megawatt-electric for ultimate disposal. For example, the tap designed for sodium cleanup is expected to be exchanged only once every thirty years. Also, inherent to ALMR's, burning waste actinides and selected fission products to preclude their accumulation and burial is very attractive. The hard neutron spectrum of ALMR burns the actinides efficiently and is not poisoned by the actinides and fission products. The modular design of PRISM components (and the fuel cycle equipment) permit replacement without expensive and potentially hazardous volume reduction. For example, the functional components of the reference electromagnetic pump and IHK can be removed intact for waste disposal. Although development of the reference metal fuel is not completed, it is estimated that (low-level) waste from recycle of the fuel will result in significantly less volume than would be generated by aqueous recycle of oxide fuel. 6 refs., 10 figs

  2. Prism adaptation reverses the local processing bias in patients with right temporo-parietal junction lesions

    Bultitude, Janet H.; Rafal, Robert D.; List, Alexandra

    2009-01-01

    Lesions to the right temporo-parietal cortex commonly result in hemispatial neglect. Lesions to the same area are also associated with hyperattention to local details of a scene and difficulty perceiving the global structure. This local processing bias is an important factor contributing to neglect and may contribute to the higher prevalence of the disorder following right compared with left hemisphere strokes. In recent years, visuomotor adaptation to rightward-shifting prisms has been intro...

  3. HEATING OF BLANK IN FORM OF PRISM IN ACCORDANCE WITH TECHNOLOGICAL LIMITATIONS

    V. B. Kovalevsky

    2014-12-01

    Full Text Available The paper considers a problem on optimum heating control of a blank in the form of prism under complicated conditions of heat-transfer in accordance with criteria of gas consumption minimization, decarburized layer and scaling. Numerical algorithm of the problem solution and examples are given in the paper. A new technology of the flame furnace operation has been developed in the paper. 

  4. Fluid circulation in the depths of accretionary prisms: an example of the Shimanto Belt, Kyushu, Japan

    Raimbourg, Hugues; Vacelet, Maxime; Ramboz, Claire; Famin, Vincent; Augier, Romain; Palazzin, Giulia; Yamaguchi, Asuka; Kimura, Gaku

    2015-01-01

    Accretionary prisms constitute ideal targets to study fluid circulation and fluid-rock interactions at depths beyond the reach of active margin deep drilling. The highest-grade rocks from the Shimanto Belt on Kyushu were buried under 3-5 kbars at ~ 300°C (Toriumi and Teruya, 1988). They contain abundant quartz veins, formed throughout burial and exhumation and variably affected by brittle and ductile deformation.Cathodoluminescence (CL) reveals the existence of two distinct types of quartz, c...

  5. A study on transmitted intensity of disturbance for air-spaced Glan-type polarizing prisms

    Fan, Ji-Yang; Li, Hong-Xia; Wu, Fu-Quan

    2002-01-01

    We study theoretically and experimentally the transmission intensity of polarized light through the air-spaced Glan-type polarizing prsims. It is found that the variation of the transmitted intensity with the rotation angle deviates from Malus Law, exhibiting a cyclic fluctuation with the rotation angle. The occurrence of the disturbance is explained by the use of an argument based on the interference effect produced from the air-gap in the prisms. The theoretcal results are well agreed with ...

  6. High-resolution NO₂ remote sensing from the Airborne Prism EXperiment (APEX) imaging spectrometer

    Popp, C; Brunner, D.; Damm, A.; Van Roozendael, M.; Fayt, C.; Buchmann, B

    2012-01-01

    We present and evaluate the retrieval of high spatial resolution maps of NO2 vertical column densities (VCD) from the Airborne Prism EXperiment (APEX) imaging spectrometer. APEX is a novel instrument providing airborne measurements of unique spectral and spatial resolution and coverage as well as high signal stability. In this study, we use spectrometer data acquired over Zurich, Switzerland, in the morning and late afternoon during a flight campaign on a cloud-free summer d...

  7. High-Order Optimal Edge Elements for Pyramids, Prisms and Hexahedra

    Bergot, Morgane; Duruflé, Marc

    2013-01-01

    Edge elements are a popular method to solve Maxwell's equations especially in time-harmonic domain. However, when non-affine elements are considered, elements of the Nedelec's first family are not providing an optimal rate of the convergence of the numerical solution toward the solution of the exact problem in H(curl)-norm. We propose new finite element spaces for pyramids, prisms, and hexahedra in order to recover the optimal convergence. In the particular case of pyramids, a comparison with...

  8. ANALISIS PENGUKURAN KINERJA PERUSAHAAN DENGAN METODE PERFORMANCE PRISM DAN SCORING OBJECTIVE MATRIX (OMAX) PADA PT. BPAS

    Adianto .; M. Agung Saryatmo; Ardi S. Gunawan

    2014-01-01

    Kinerja merupakan suatu tampilan keadaan secara utuh atas perusahaan selama periode waktu tertentu. PT. BPAS adalah sebuah perusahaan yang bergerak dalam bidang industri papan semen. Selama ini sistem pengukuran kinerja di PT. BPAS belum merepresentasikan kinerja organisasi secara komprehensif dan integratif. Oleh sebab itu pengukuran kinerja perlu dilakukan pada PT. BPAS dengan menggunakan metode Performance Prism dan Scoring OMAX agar dapat meningkatkan kinerja perusahaan secara maksimal. P...

  9. High-resolution NO₂ remote sensing from the Airborne Prism EXperiment (APEX) imaging spectrometer

    Popp, C; Brunner, Dominik; DAMM Alexander; M. Van Roozendael; C. Fayt; B. Buchmann

    2012-01-01

    We present and evaluate the retrieval of high spatial resolution maps of NO₂ vertical column densities (VCD) from the Airborne Prism EXperiment (APEX) imaging spectrometer. APEX is a novel instrument providing airborne measurements of unique spectral and spatial resolution and coverage as well as high signal stability. In this study, we use spectrometer data acquired over Zurich, Switzerland, in the morning and late afternoon during a flight campaign on a cloud-free summer day in June 2010. N...

  10. Existence of a Diffusion Length in a Finite Prism of Pure Moderator

    An exact integral transport equation is derived for the neutron flux in a finite prism of pure moderator. Assuming that the prism is infinite in the z-direction, a trial solution expi(-vz) is inserted, and an eigenvalue problem for v, the spatial relaxation constant, results. The eigenvalue v is studied as a function of the absorption and dimensions of the prism. It is shown that the discrete eigenvalues are bounded by Σmin, and that a minimum dimension exists below which a diffusion length can no longer be found. This result is much more restrictive than the maximum absorption theorem of Comgold, and the minimum dimension of the prism is shown to correspond to transverse bucklings of 10-3 cm2 for beryllium, and 1.5 x 10-3cm2 for graphite, at 300°K. For poisoned and low-temperature moderators these values will be even smaller. The angular distribution of the neutrons in the moderator has been calculated perpendicular and parallel to the axis, and it is found that a marked anisotropy of the spectrum exists, particularly in the neighbourhood of the Bragg cut-off. On the basis of degenerate kernel approximation to the scattering process, it is shown that when the system is such that no diffusion length exists, then the asymptotic transverse flux shape is no longer of the cosine type, but becomes progressively flatter as the distance from the source increases. This is due to an increase in the proportion of cold neutrons which have longer mean free paths than the average. The well-known cold neutron filtering effect can be explained in terms of this phenomenon. The results obtained from the present analysis are in quantitative agreement with recent experiments performed by De Juren and Swanson. (author)

  11. PRISM: a web server and repository for prediction of protein–protein interactions and modeling their 3D complexes

    Baspinar, Alper; Cukuroglu, Engin; Nussinov, Ruth; Keskin, Ozlem; Gursoy, Attila

    2014-01-01

    The PRISM web server enables fast and accurate prediction of protein–protein interactions (PPIs). The prediction algorithm is knowledge-based. It combines structural similarity and accounts for evolutionary conservation in the template interfaces. The predicted models are stored in its repository. Given two protein structures, PRISM will provide a structural model of their complex if a matching template interface is available. Users can download the complex structure, retrieve the interface r...

  12. Measurement of Stress-Strain Response of A Rammed Earth Prism In Compression Using Fiber Bragg Grating Sensors

    Prasad, Guru AS; Anitha, M.; Rao, Nanjunda KS; S. Asokan

    2011-01-01

    A comparative study of strain response and mechanical properties of rammed earth prisms, has been made using Fiber Bragg Grating (FBG) sensors (optical) and clip-on extensometer (electro-mechanical). The aim of this study is to address the merits and demerits of traditional extensometer vis-à-vis FBG sensor; a uni-axial compression test has been performed on a rammed earth prism to validate its structural properties from the stress - strain curves obtained by two different methods of measurem...

  13. Optimization of the laser beam propagation conditions in the prism stretcher of THL-100 multiterawatt laser system

    Ivanov, Mikhail Vladimirovich; Alekseev, Sergey Vladimirovich; Ivanov, Nikolay Georgievich; Losev, Valery Fedorovich

    2015-01-01

    The influence of the optical inhomogeneities effect of the prism stretcher elements on the spatial, angular and spectral parameters of the transmitted radiation and the degree of change in the phase aberrations of the laser beam during its propagation in the stretcher are studied. It is shown that the prism material does not allow transmitting of a required diameter of 75 mm without linear distortions of the beam. The maximum intensity and beam diameter allowing to amplify the picosecond puls...

  14. Approximation of H(div) with High-Order Optimal Finite Elements for Pyramids, Prisms and Hexahedra

    Bergot, Morgane; Duruflé, Marc

    2013-01-01

    Classical facet elements do not provide an optimal rate of convergence of the numerical solution toward the solution of the exact problem in H(div)-norm for general unstructured meshes containing hexahedra and prisms. We propose two new families of high-order elements for hexahedra, triangular prisms and pyramids that recover the optimal convergence. These elements have compatible restrictions with each other, such that they can be used directly on general hybrid meshes. Moreover the H(div) p...

  15. Diamond-coated ATR prism for infrared absorption spectroscopy of surface-modified diamond nanoparticles

    Linear antenna microwave chemical vapor deposition process was used to homogeneously coat a 7 cm long silicon prism by 85 nm thin nanocrystalline diamond (NCD) layer. To show the advantages of the NCD-coated prism for attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) of nanoparticles, we apply diamond nanoparticles (DNPs) of 5 nm nominal size with various surface modifications by a drop-casting of their methanol dispersions. ATR-FTIR spectra of as-received, air-annealed, plasma-oxidized, and plasma-hydrogenated DNPs were measured in the 4000–1500 cm−1 spectral range. The spectra show high spectral resolution, high sensitivity to specific DNP surface moieties, and repeatability. The NCD coating provides mechanical protection against scratching and chemical stability of the surface. Moreover, unlike on bare Si surface, NCD hydrophilic properties enable optically homogeneous coverage by DNPs with some aggregation on submicron scale as evidenced by scanning electron microscopy and atomic force microscopy. Compared to transmission FTIR regime with KBr pellets, direct and uniform deposition of DNPs on NCD-ATR prism significantly simplifies and speeds up the analysis (from days to minutes). We discuss prospects for in situ monitoring of surface modifications and molecular grafting.

  16. Possibilities of magnet prism β-spectrometer application in on-line experiments

    The main attention is paid to works with particle beam in up-to-date nuclear investigations. The application of magnet prism β-spectrometer for works in 'on-line' experiments is considered in this article. The source chamber and detector chamber are distanted from each other on great distance (4 m) and are out of operation field of spectrometer. There is a reliable defence of operating field of device from external parasitic fields by the magnetic screens system. The additional advantage is a factor that source (target) and detector could replacing in specific directions about few centimetres during the device operating. The main β-spectroscopic performances of device are compared with Grenoble spectroscopic complex. The liner depression of prism spectrometer account for from 3,6 up to 6 m; light force - from 2·10-4 up to 6·10-4 up to 4π; operating resolving power - 0,02-0,05% by impulse. Investigation range is from several keV up to 3 MeV. There are all opportunities for installing of the on-line magnetic prism spectrometer on the U-150 accelerator and the WWR-K reactor. Spectrometer application in 'on-line' experiments gives possibility to obtain more wide information. 4 refs

  17. Standard neutron fields in graphite prism with Ra-α-Be source

    Neutron slowing-down and space-energy distribution of neutron flux in graphite prism with Ra-α-Be source were investigated experimentally, numerically and theoretically. Recent measurement and numerical experiment based on Monte Carlo calculations were carried out for the purpose of determining detailed space and energy distribution of neutron flux in the prism. Measurement of two-group neutron flux distribution along the central vertical axis of graphite prism was performed by irradiation of golden foils with cadmium covers and without them. Gamma and beta activities of foils were measured absolutely by using coaxial semiconductor germanium gamma detector and dual gas proportional alpha/beta detector, respectively. Starting from the results of numerical Monte Carlo experiment, neutron ages that enable analytical representation of neutron flux in broad energy intervals were determined. For the six chosen broad energy intervals the very good agreement between numerical experiment and Fermi age theory results was achieved with three age groups, corresponded source fractions and neutron ages. (author)

  18. Polarization properties in a prism laser gyro with mechanical dither bias

    Theoretical analysis and experimental research on the polarization properties of output light in gyro are carried out to investigate the phenomenon that the amplitude of an output voltage signal is modulated by dither bias in laser gyros consisting of totally reflecting prisms. Taking the effect of prism stress birefringence into account, an analytical formula of the output light intensity in the gyro and the relationship between the polarization parameter and the amplitude modulation of the output signal are obtained and discussed. For the first time, the polarized power value of the output light is adopted as a basis to estimate the output signal amplitude fading extent of laser gyros. Experimental results demonstrate that when the value of polarized power of output light is below 25.5% of that in ideal static case, the standard error is over 0.0337 dBm, and the displacement extent of the prism is higher than 53% of the radius of the beam waist in the gyro cavity, the amplitude modulation extent of gyro output signal can reach up to 16%, which badly influences the measurement accuracy of the laser gyro. Using this polarized power detecting measurement method can repair the gyro immediately during its fabrication process, improve the testing and production efficiency and shorten the product development cycle. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  19. An angular fluidic channel for prism-free surface-plasmon-assisted fluorescence capturing

    Nomura, Ken-Ichi; Gopinath, Subash C. B.; Lakshmipriya, Thangavel; Fukuda, Nobuko; Wang, Xiaomin; Fujimaki, Makoto

    2013-12-01

    Surface plasmon excitation provides stronger enhancement of the fluorescence intensity and better sensitivity than other sensing approaches but requires optimal positioning of a prism to ensure optimum output of the incident light. Here we describe a simple, highly sensitive optical sensing system combining surface plasmon excitation and fluorescence to address this limitation. V-shaped fluidic channels are employed to mimic the functions of a prism, sensing plate, and flow channel in a single setup. Superior performance is demonstrated for different biomolecular recognition reactions on a self-assembled monolayer, and the sensitivity reaches 100 fM for biotin-streptavidin interactions. Using an antibody as a probe, we demonstrate the detection of intact influenza viruses at 0.2 HA units ml-1 levels. The convenient sensing system developed here has the advantages of being prism-free and requiring less sample (1-2 μl), making this platform suitable for use in situations requiring low sample volumes.

  20. Research on refractive index of optical cement used in Glan-Thompson prisms

    Haifeng Wang; Fuquan Wu; Hailong Wang; Jing Wang; Shan Zhang

    2007-01-01

    The influence of the refractive index n2 of optical cement on the structure angle, field angle, and transmission of Glan-Thompson prism has been studied in detail. The results show that the structure angle will increase with the decrease of n2 under the condition of the largest field angle. Thus, the ratio of length to width (L/A) of the prism will decrease, which means more materials can be saved. When the value of L/A is 3.0 or 2.5 in the routine design, the field angle will firstly increase and then decrease with the increment of n2. Two routine designs with the n2 values of 1.47 and 1.45 have the optimal field angle. In addition, n2 also has great influence on light intensity transmittance of the prism. Considering all these factors, it will be the best choice with L/A=2.5 and n2 = 1.45 - 1.46.

  1. A 1-Diopter Vertical Prism Induces a Decrease of Head Rotation: A Pilot Investigation

    Matheron, Eric; Zandi, Ava; Wang, Danping; Kapoula, Zoï

    2016-01-01

    Clinical studies in non-specific chronic arthralgia and back pain seem to indicate an association between vertical heterophoria (VH – latent vertical retinal misalignment) and asymmetrical head rotation. Such clinical observations suggest a link between VH and head rotation, but this was never tested. The purpose of this study was to simulate a VH in healthy subjects and examine its influence on the amplitude of active head rotation during 3D motion capture in upright stance. Subjects were asked to rotate their head three times from the straight ahead position and then to the right, back to straight ahead, to the left, and back to the straight ahead again. Three randomized conditions were run: normal viewing, with a 1-diopter prism base down on the dominant eye, or the non-dominant eye. The most important finding is that the experimental VH whichever the eye with the prism induces a significant decrease in the mean angle of head rotation compared to the normal viewing condition. This decrease was significant for rotation to the left. We suggest that the prism-induced VH modifies the reference posture and thereby affects head rotation; further studies are needed to confirm this effect and to extend to other types of dynamic activities. PMID:27199886

  2. Solving the Camera Intrinsic Parameters with the Positive Tri-prism Based on the Circular Points

    Hui Wang

    2012-01-01

    Full Text Available This study proposed a method of camera self-calibration with the positive tri-prism. The coordinates of circular points can be obtained through the properties of positive tri-prism. According to the theory of projective transformation, the coordinates of the vanishing points of each edges of positive tri-prism can be obtained. After that, combined with the corollary of Laguerre theorem (the infinity points of two mutually perpendicular lines and the circular points harmonic conjugate, one can obtain the image coordinates of the circular points. By computing coordinates of whole the circular points in an image, according to the constraints on the intrinsic parameters which are established through image of the absolute-conic, we can obtain the intrinsic parameters linearly. The method algorithm has been tested on both computer simulated data and real data. The technique only required single target image and the orientation of camera did not need to be known. The results gained considerable robustness.

  3. Deformation-induced diagenesis and microbial activity in the Nankai accretionary prism

    Famin, V.; Andreani, M.; Boullier, A. M.; Raimbourg, H.; Magnin, V.

    2014-12-01

    We performed a microscopic and chemical study of diagenetic reactions in deformation microstructures within deep mud sediments from the Nankai accretionary prism (SW Japan) collected during IODP Expedition 315. Our study reveals that deformation microstructures localize the crystallization of pyrite, a diagenetic reaction also found in large megasplay faults of the prism. Textural observation shows that pyrite crystallization is synchronous of the sediment deformation. The framboidal shape of pyrite crystals, the barium depletion and the strong arsenic enrichment observed in deformation microstructures compared with the sediment matrix, suggest that pyrite crystallization is mediated by the proliferation of anoxic archae. During scientific drilling expeditions IODP 315, 316 and 319, microbial life has been evidenced at depths of up to 800 m below the sea floor by the presence of biogenic methane and sulfate reducers in sediments. We suggest that deformation structures localize microbial proliferation because the fracturing of silicate minerals produces hydrogen, a necessary compound for bacteria under anoxic conditions. Bacteria proliferate as long as active deformation supplies hydrogen, and vanish when the deformation stops. The development of bacteria in deformation structures impacts our mechanical understanding of fault zones in accretionary prisms: Firstly, bacterial activity converts carbon from organic matter and hydrogen into methane and/or water, which may alter the fluid budget of fault zones and the recurrence of dynamic ruptures in megathrusts. Secondly, the abundance of bacteria could be used to recognize active fault zones from inactive ones in drilling cores.

  4. ONE-DIMENSIONAL LIGHT BEAM WIDENING USING PRISMS FOR INCREASE OF SPECTROMETER SPECTRAL RESOLUTION AND ANGULAR DISPERSION

    I. M. Gulis

    2016-01-01

    Full Text Available The increase of angular dispersion and slit resolution limit of grating spectrometers by means of variation of grating parameters is limited by its period and allowable order of diffraction. The special solutions (echelle, holographic, immersion gratings are acceptable in a limited parameter range and are technologically complex in fabrication, thus hardly applicable to instruments of mass production. We propose to decrease slit resolution limit by one-dimensional beam widening in dispersion plane by means of passing it through oblique prism before incidence onto diffraction grating. The increase of angular dispersion can be achieved by narrowing of dispersed beams after grating while passing through other oblique prism. We prove that slit resolution limit in such a system changes approximately as multiplied by angular magnification of the first prism (that is less than 1 times. Also angular dispersion changed approximately as multiplied by angular magnification of the second prism. The Fresnel reflection from the faces of prisms is analyzed. Accounting for that factor gives the increase of resolution about 1,4–1,6 times without loss of light (and can be 2 and more times while using anti-reflective coating. The proposed method is different from the similar ones first of all by its simplicity because it uses simple optical elements – plane reflective grating and thin prisms. It can be applied to amend the analytical characteristics of dispersive spectrometers, first of all the small-sized ones. 

  5. Implications of Faulting Styles in the Outer Wedge of the Nankai Accretionary Prism, Japan

    Kington, J. D.; Tobin, H. J.

    2009-12-01

    The Nankai Trough, Japan near Kumano Basin displays a well developed accretionary prism with a major out-of-sequence “megasplay” thrust separating the recently active outer wedge of the prism from the forearc basin deposits. While not in the seismogenic zone, this thrust is thought to play a key role in tsunamigenesis by transferring deeper coseismic slip to the seafloor. Understanding the development of this fault requires a detailed understanding of the kinematics and structure of the outer wedge of the accretionary prism. The outer wedge of the Nankai accretionary prism consists of an in-sequence series of landward-dipping thrusts that record two directions of shortening. Based on 3D reflection seismic, older thrusts and their associated folds strike ~225 degrees, almost exactly perpendicular to plate motion in the area, which has an azimuth of 314 (Zang, et al, 2002). The youngest thrusts, including the megasplay at the rear of the outer wedge, trend 240-245 degrees, subparallel to the margin in the area, which trends roughly 250. This suggests two possibilities: 1) the older thrusts formed during a period of relatively strong coupling with the subducting slab, perhaps due to highly irregular oceanic basement topography which has since been subducted, or 2) the trench margin had been previously indented by a subducted seamount and has since been rebuilding. In addition, two right lateral tear faults with offsets of approximately 1km cut the fold-thrust belt of the outer wedge. These faults cleanly offset the fold hinge of faults striking perpendicular to plate motion and interact with the oldest faults that strike parallel to the margin, implying that their timing is coincident with the change in shortening direction. Therefore, these tear faults may accommodate along-strike changes in the taper angle of the accretionary prism following the subduction of irregular basement topography. Significant normal faulting within the seismically imaged portion of the

  6. PERANCANGAN DAN IMPLEMENTASI SISTEM PENGUKURAN KINERJA DENGAN METODE PERFORMANCE PRISM (Studi Kasus pada Hotel X

    Iwan Vanany

    2004-01-01

    Full Text Available This article described a result of research design of performance measurement system in hotel business with Performance Prism Model. As long as, performance measurement system at hotel X not yet representatived organization performance according to comprehensif and integrated. Because of needed redesign performance measurement system with new model. From the objective condition of hotel X, Performance Prism model more representative than others. The result of design described that stakeholder in hotel X such as: customer, employee, supplier, owner and investor, and regulator and community. From the performance measurement system design are obtained 36 types Key Performance Indicator (KPI such as: 6 KPI of customer, 9 KPI of staff manajerial, 9 KPI of staff operational, 4 KPI of supplier, 3 KPI of investor, and 5 KPI of regulator & community. Result of implementation performance measurement system with scoring system indicates that the amount of scor current performance indicator is 50,75%. Result of measurement can be based management act evaluation and choice planning improvement organization and all Stakeholder requirements must be request. Abstract in Bahasa Indonesia : Artikel ini menguraikan hasil penelitian perancangan sistem pengukuran kinerja pada sebuah perusahaan dalam bisnis hotel dengan model Performance Prism. Selama ini, sistem pengukuran kinerja di Hotel X belum merepresentasikan kinerja organisasi secara komprehensif dan integratif. Oleh karena itu, perlu dilakukan perancangan kembali sistem pengukuran kinerjanya. Dari kondisi objektif hotel X, model yang tepat digunakan adalah model Performance Prism dibanding model lain. Hasil rancangan menunjukkan bahwa stakeholder hotel X meliputi: konsumen, tenaga kerja, supplier, pemilik/investor, serta pemerintah dan masyarakat sekitar lingkungan hotel. Sistem pengukuran kinerja memuat 36 KPI yang meliputi 6 KPI konsumen, 9 KPI staff manajerial, 9 KPI staff operasional, 4 KPI supplier, 3

  7. GPC3 fused to an alpha epitope of HBsAg acts as an immune target against hepatocellular carcinoma associated with hepatitis B virus

    Jun-Wen Yang; Dong-Ye Yang; Fang-Gen Lu; Cai-Hong Li; Hui Chen; Ning Xie; Xin Zhao

    2011-01-01

    BACKGROUND: The incidence of hepatocellular carcinoma (HCC) in China is closely related to the population infected with hepatitis B virus (HBV). HCC cells with HBV secrete soluble HBsAg into blood but do not express it on the cell membrane. This study aimed to construct and investigate a new glycosyl-phosphatidylinositol (GPI)-anchored protein (GPC3+α+EGFP) as a DNAvaccineagainstHCCassociatedwithHBV. METHODS: A recombinant plasmid (pcDNA3.1(+)/GPC3+α+EGFP) was constructed and verified by restriction endo-nuclease digestion and sequencing. pcDNA3.1(+)/GPC3+α+EGFP was transfected into HepG2 cells (experimental group) using lipofectamine 2000. pEGFP-N1-transfected HepG2 cells were used as a negative control, and non-transfected HepG2 cells sreved as a blank control. HepG2 cells that steadily expressed the fusion protein GPC3+α+EGFP were screened by G418, propagated, and co-cultured with lymphocytes from healthy donors. Cell proliferation was measured by the classic sulforhodamine B assay. Apoptosis was assessed by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL), and Fas gene transcription was determined by quantitative fluorescent PCR. RESULTS:  The pcDNA3.1(+)/GPC3+α+EGFP plasmid was successfully constructed. In the experimental group, green fluorescence was observed at the cell periphery and in the cytoplasm, whereas in the negative control group, fluorescence was evenly distributed throughout the cell. Proliferation of the experimental group significantly decreased after 72 hours compared to the negative and blank control groups. Furthermore, the number of apoptotic cells was statistically different among the three groups as determined by a contingency table Chi-square test; the experimental group had the highest incidence of apoptosis. Fas gene transcription in the experimental group was higher than in the two control groups, and an increasing trend with time in the experimental group was observed. CONCLUSION: A chimeric

  8. 制备源自HBsAg基因修饰树突状细胞的外切体%Generation of exosomes derived from adenovirus-mediated HBsAg gene-modified dendritic cells

    杨静悦; 高琳; 付蓉; 薛妍; 刘文超

    2012-01-01

    Objective: To obtain exosomes derived from adenovirus - mediated HBsAg gene - modified dendritic cells. Methods: Full length HBsAg cDNAs were cloned into shuttle2 vector. The HBsAg gene fragments resulted from the - S digested with PI - See and I - Ceu were linked to the linear adeno - X virus DNA. After packaged with HEK293 cells, the adenovirus expression vector was obtained. Then the recombinant adenovirus expression plasmid AdVHBsAg was transfected into human monocyte - derived dendritic cells. The exosomes were isolated from superna-tant of transfected DCs. Transmission electron microscopy was used to observe their structures. The expressions of several proteins were investigated by flow cytometry. Results: The shuttle2 - S showed that band with 630 bp by di-gested with PI - See and I - Ceu, HBsAg gene in the inserted DNA of AdVHBsAg was confirmed by PCR, and pre-dictive fragments proved by restriction enzyme digestion analysis were exhibited. CPE appear 10 after days HEK293 cells transfected AdVHBsAg. Application of the isolation procedure to transfected DCs revealed exosome vesicles by transmission electron microscopy. Protein analysis by Western blot was performed and revealed that the costimulatory molecule CD86,CD83 and HBsAg was detectable. Conclusion; The exosomes derived from HBsAg - DC may be a tool of the HBV related hepatocellular carcinoma immunotherapy.%目的:制备一种新型负载HBsAg基因的外切体(exosome)瘤苗,并探讨其生物学特性、免疫学功能.方法:运用分子克隆和病毒载体转染HBsAg基因构建AdVHBsAg-DC肝癌瘤苗,采用流式细胞术鉴定转染基因表达;提取exosome;以透射电镜观察、Western blot法鉴定exosome.结果:构建的重组AdVHBsAg腺病毒载体,经PCR和酶切鉴定,结果显示HBsAg基因片段已正确插入腺病毒载体中.包装的腺病毒载体具有良好的感染性,可以在293细胞中形成病毒颗粒.提取的exosome在透射电镜下可观察到直径为50-100nm

  9. Mercury contamination from mine and natural sources in Harley Gulch, downstream from the Abbott and Turkey Run Mercury Mines, Lake County, California

    Hothem, R. L.; Rytuba, J. J.; Goldstein, D.; Brussee, B.

    2011-12-01

    The Abbott and Turkey Run Mercury (Hg) mine area in central California has released Hg tailings into the Harley Gulch watershed since 1862. Harley Gulch flows into Cache Creek which is a significant source of Hg into San Francisco Bay Delta. Thermal mine water effluent emanating from the Turkey Run adit flows into the upper part of the watershed. Despite remediation efforts, Hg tailings and enriched sediment remain in the Harley Gulch wetlands and in the creek downstream from the mine area. Water, sediment, and biota have been sampled from below the mine area to 15 km downstream to the confluence with Cache Creek in order to assess the impact of Hg on water quality and biota. Two previously unrecognized natural sources of Hg in the watershed are connate groundwater with elevated levels of Hg, and biogenic sediment composed of phytoplankton that accumulates in the upper part of the watershed during the dry season. The connate groundwater source contains isotopically-heavy Mg-Ca-Cl-CO3-SO4 water that has elevated concentrations of Ba, W, Ti, and Hg. This water first enters Harley Gulch in the central part of the wetland immediately downstream from the mine area and continues to contribute water downstream for a distance of 1.5 km. It is both chemically and isotopically distinct from the thermal mine water effluent from the Turkey Run adit. The biogenic source consists of blooms of phytoplankton that accumulate to a thickness of up to 0.2 m. Phytoplankton have a large bioaccumulation factor of Hg and monomethyl mercury (MMeHg) that results in a high concentrations of Hg and MMeHg (Hg: 5-25 μg/g, MMeHg 5.2 ng/g) in the biogenic sediment. The tan biogenic sediment at the surface consists of living diatoms and below it is a layer of black reduced biogenic sediment consisting of diatom fragments with micron- to submicron-sized FeS, HgS, and barite grains. Sulfate-reducing bacteria reduce sulfate to sulfide in the pore waters of the biogenic sediment that reacts with

  10. Prevalence of HBsAg, knowledge, and vaccination practice against viral hepatitis B infection among doctors and nurses in a secondary health care facility in Lagos state, South-western Nigeria

    Abiola, Abdul-Hakeem Olatunji; Agunbiade, Adebukola Bola; Badmos, Kabir Bolarinwa; Lesi, Adenike Olufunmilayo; Lawal, Abdulrazzaq Oluwagbemiga; Alli, Quadri Olatunji

    2016-01-01

    Introduction Hepatitis B Virus, a highly infectious blood-borne virus poses a major threat to public health globally due to its high prevalence rate and grave consequence in causing liver cirrhosis and hepatocelullar carcinoma, the third cause of cancer death worldwide. The aim is determine the prevalence of HBsAg, knowledge, and vaccination practices against viral hepatitis B infection among doctors and nurses in a health care facility. Methods Study design was a descriptive cross-sectional study among all the doctors and nurses in the health care facility. Data was collected using pre-tested, structured, self-administered questionnaire and blood samples were taken from respondents and tested using commercial enzyme-linked immunosorbent assay (ELIZA) test kit to determine prevalence of hepatitis B surface antigen after informed consent. Ethical approval was obtained from Health Research and Ethics Committee of the Lagos University Teaching Hospital. Responses of the respondents to the knowledge and vaccination practices against viral hepatitis B infection were scored and graded as poor (viral hepatitis B infection. Mean knowledge and vaccination practices scores (%) were 72.54+7.60 and 29.44+14.37 respectively. Only 29% of the respondents did post vaccination testing for anti HBsAg. Conclusion Prevalence of HBsAg was low. Knowledge of viral hepatitis B was fair, and practice of post hepatitis B vaccination testing was poor. It is therefore recommended that the state ministry of health should organise further health education programme, institute compulsory occupational hepatitis B vaccination programme and post vaccination anti-HBS testing to ensure adequate antibody level in this adult population. PMID:27303576

  11. Model and Visualization of Ray Tracing using JavaScript and HTML5 for TIR Measurement System Equipped with Equilateral Right Angle Prism

    Viridi, Sparisoma; Hendro

    2013-01-01

    Trace of ray deviated by a prism, which is common in a TIR (total internal reflection) measurement system, is sometimes difficult to manage, especially if the prism is an equilateral right angle prism (ERAP). The point where the ray is reflected inside the right-angle prism is also changed as the angle of incident ray changed. In an ATR (attenuated total reflectance) measurement system, range of this point determines size of sample. Using JavaScript and HTML5 model and visualization of ray tr...

  12. Arctic PRISM Shorebird Location and Plot Survey Geodatabase. U.S. Fish and Wildlife Service, Division of Migratory Bird Management (2012).

    Arctic Landscape Conservation Cooperative — This dataset consists of shorebird surveys conducted as part of the Program for Regional and International Shorebird Monitoring (PRISM). This dataset was derived...

  13. Evaluation of 3 automated real-time PCR (Xpert C. difficile assay, BD MAX Cdiff, and IMDx C. difficile for Abbott m2000 assay) for detecting Clostridium difficile toxin gene compared to toxigenic culture in stool specimens.

    Yoo, Jaeeun; Lee, Hyeyoung; Park, Kang Gyun; Lee, Gun Dong; Park, Yong Gyu; Park, Yeon-Joon

    2015-09-01

    We evaluated the performance of the 3 automated systems (Cepheid Xpert, BD MAX, and IMDx C. difficile for Abbott m2000) detecting Clostridium difficile toxin gene compared to toxigenic culture. Of the 254 stool specimens tested, 87 (48 slight, 35 moderate, and 4 heavy growth) were toxigenic culture positive. The overall sensitivities and specificities were 82.8% and 98.8% for Xpert, 81.6% and 95.8% for BD MAX, and 62.1% and 99.4% for IMDx, respectively. The specificity was significantly higher in IMDx than BD MAX (P= 0.03). All stool samples underwent toxin A/B enzyme immunoassay testing, and of the 254 samples, only 29 samples were positive and 2 of them were toxigenic culture negative. Considering the rapidity and high specificity of the real-time PCR assays compared to the toxigenic culture, they can be used as the first test method for C. difficile infection/colonization. PMID:26081240

  14. Machining characteristics of complex prism pattern on electroplated roll by copper

    Tae-Jin JE; Sang-Cheon PARK; Kang-Won LEE; Yeong-Eun YOO; Doo-Sun CHOI; Kyung-Hyun WHANG; Myung-Chang KANG

    2009-01-01

    The BLU (back light unit)is the core component of the LCD for notebook, mobile-phone, navigation, as well as large sized TV, PID (public information display), etc. In order to enhance optical efficiency of LCD, optical films with the uniform prism patterns have been used for BLU by stacking two films up orthogonally. In this case, light interference-phenomenon occurred such as Morie, wet-out, u-turning, etc. It caused several problems such as low brightness, spots and stripes in LCD. Recently, the high-luminance micro complex prism patterns are actively studied to avoid the light interference-phenomenon and enhance the optical efficiency. In this study, the roll master to manufacture complex micro prism pattern film was machined by using the high precision lathe. The machined patterns on the roll master were 50, 45, 40, 35, 30, 25, 20, 15, 10 and 5μm in the pitch with 25.0, 22.5, 20.0, 17.5, 15.0, 12.5, 10.0, 7.5, 5.0 and 2.5 μm in the peak height, respectively. The roll was 2 000 mm in length and 320 mm in diameter. The electroplated roll by copper and the natural single crystal diamond tool was used for machining the patterns. The cutting force was measured and analyzed for each cutting condition by using the dynamometer. The chips and the surfaces after being machined were analyzed by SEM and microscope.

  15. Dynamics of dual prism adaptation: relating novel experimental results to a minimalistic neural model.

    Orlando Arévalo

    Full Text Available In everyday life, humans interact with a dynamic environment often requiring rapid adaptation of visual perception and motor control. In particular, new visuo-motor mappings must be learned while old skills have to be kept, such that after adaptation, subjects may be able to quickly change between two different modes of generating movements ('dual-adaptation'. A fundamental question is how the adaptation schedule determines the acquisition speed of new skills. Given a fixed number of movements in two different environments, will dual-adaptation be faster if switches ('phase changes' between the environments occur more frequently? We investigated the dynamics of dual-adaptation under different training schedules in a virtual pointing experiment. Surprisingly, we found that acquisition speed of dual visuo-motor mappings in a pointing task is largely independent of the number of phase changes. Next, we studied the neuronal mechanisms underlying this result and other key phenomena of dual-adaptation by relating model simulations to experimental data. We propose a simple and yet biologically plausible neural model consisting of a spatial mapping from an input layer to a pointing angle which is subjected to a global gain modulation. Adaptation is performed by reinforcement learning on the model parameters. Despite its simplicity, the model provides a unifying account for a broad range of experimental data: It quantitatively reproduced the learning rates in dual-adaptation experiments for both direct effect, i.e. adaptation to prisms, and aftereffect, i.e. behavior after removal of prisms, and their independence on the number of phase changes. Several other phenomena, e.g. initial pointing errors that are far smaller than the induced optical shift, were also captured. Moreover, the underlying mechanisms, a local adaptation of a spatial mapping and a global adaptation of a gain factor, explained asymmetric spatial transfer and generalization of prism

  16. High-performance beam steering using electrowetting-driven liquid prism fabricated by a simple dip-coating method

    Enrico Clement, Carlos; Park, Sung-Yong

    2016-05-01

    A high degree of beam steering is demonstrated using an electrowetting-driven liquid prism. While prism devices have typically relied on complex and expensive laboratory setups, such as high-vacuum facilities for fabrication of dielectric layers, this work utilizes a simple dip-coating method to provide an ion gel layer as a dielectric, offering 2 or 3 orders higher specific capacitance (c ≈ 10 μF/cm2) than that of conventional dielectrics. Analytical studies present the effects of liquid selection and arrangement on overall prism performance. For experimental demonstrations of high-performance beam steering, we not only selected two immiscible liquids of water and 1-bromonaphthalene (1-BN) oil which provide the large refractive index difference (nwater = 1.33 and n1-BN = 1.65 at λ = 532 nm) between them, but also utilized a double-stacked prism configuration which increases the number of interfaces for incoming light to be steered. At a prism apex angle of φ = 27°, we were able to achieve significantly large beam steering of up to β = 19.06°, which is the highest beam steering performance ever demonstrated using electrowetting technology.

  17. Simplified analysis of PRISM RVACS [Reactor Vessel Auxiliary Cooling System] performance without liner spill-over

    Simplified analysis of the performance of the PRISM RVACS decay heat removal system under off-normal conditions, i.e., without the liner spill-over, is described. Without the spilling of hot-pool sodium over the liner and the resultant down-flow along the inside of the reactor vessel wall, the RVACS system performance becomes dominated by the radial heat condition and radiation. Simple estimates of the resulting heat conduction and radiation processes support GE's contention that the RVACS performance is not severely impacted by the absence of spillover, and can improve significantly if sodium has leaked into the region between the reactor and containment vessels. 7 refs

  18. PRISM (Polarized Radiation Imaging and Spectroscopy Mission): an extended white paper

    PRISM (Polarized Radiation Imaging and Spectroscopy Mission) was proposed to ESA in May 2013 as a large-class mission for investigating within the framework of the ESA Cosmic Vision program a set of important scientific questions that require high resolution, high sensitivity, full-sky observations of the sky emission at wavelengths ranging from millimeter-wave to the far-infrared. PRISM's main objective is to explore the distant universe, probing cosmic history from very early times until now as well as the structures, distribution of matter, and velocity flows throughout our Hubble volume. PRISM will survey the full sky in a large number of frequency bands in both intensity and polarization and will measure the absolute spectrum of sky emission more than three orders of magnitude better than COBE FIRAS. The data obtained will allow us to precisely measure the absolute sky brightness and polarization of all the components of the sky emission in the observed frequency range, separating the primordial and extragalactic components cleanly from the galactic and zodiacal light emissions. The aim of this Extended White Paper is to provide a more detailed overview of the highlights of the new science that will be made possible by PRISM, which include: (1) the ultimate galaxy cluster survey using the Sunyaev-Zeldovich (SZ) effect, detecting approximately 106 clusters extending to large redshift, including a characterization of the gas temperature of the brightest ones (through the relativistic corrections to the classic SZ template) as well as a peculiar velocity survey using the kinetic SZ effect that comprises our entire Hubble volume; (2) a detailed characterization of the properties and evolution of dusty galaxies, where the most of the star formation in the universe took place, the faintest population of which constitute the diffuse CIB (Cosmic Infrared Background); (3) a characterization of the B modes from primordial gravity waves generated during inflation

  19. Q-switching of a microchip laser using a plasma prism

    We demonstrate a novel method for active and passive Q-switching of a bulk laser source. The mechanism is based on the deflection of laser light through an electric channel of plasma that is temporarily created inside the resonator. The channel of plasma consists of an electric spark in air actuated with a spark gap. It acts as a spatio-temporal prism that momentarily enables the laser light to oscillate resonantly, thus triggering the creation of a laser pulse. Nanosecond pulses from a microchip laser source have been obtained with a limited timing jitter

  20. Modeling of turbulent flow in the neighborhood of forced and freely oscillating rectangular prisms

    The problem of incompressible two-dimensional viscous flow past an infinite prism of rectangular cross section subjected to forced or free oscillation in the transverse direction is considered. The complete Reynolds equations, closed by means of a two-parameter k-ε-model of turbulence, are solved numerically in the noninertial coordinate system. The coefficients of the aerodynamic forces acting on the body are calculated as time functions; in the case of free oscillations the paths of the body and the instantaneous velocities of the oscillatory motion are calculated

  1. Reflected beam parameters during excitation of a waveguide with cubic nonlinearity through a prism coupler

    The problem of the field of TE-polarized light beam reflected from the prism during excitation of an optical waveguide possessing cubic nonlinearity is solved. The effect of nonlinear switching is studied taking into account the amplitude distribution of the exciting beam and nonlinear absorption. New possibilities of determining the nonlinear constants of waveguide layers form the intensity distribution of the reflected beam are found. The results of experimental study of the As2S3 film waveguide are presented. 20 refs., 4 figs

  2. Spectroscopic Evidence for the Tricapped Trigonal Prism Structure of Semiconductor Clusters

    We have obtained photoelectron spectra (PES) for silicon cluster anions with up to 20 atoms. Efficient cooling of species in the source has allowed us to resolve multiple features in the PES for all sizes studied. Spectra for an extensive set of low-energy Sin- isomers found by a global search have been simulated using density functional theory and pseudopotentials. Except for n=12 , calculations for Sin- ground states agree with the measurements. This does not hold for other plausible geometries. Hence PES data validate the tricapped trigonal prism morphologies for medium-sized Si clusters. (c) 2000 The American Physical Society

  3. Multiple surface plasmon waves in [prism/Ag/SiO2 helical thin film] Kretschmann configuration

    Two surface plasmon resonance dips in reflectance angular spectrum for a p-polarized incident beam of a [prism/Ag/SiO2 helical thin film] Kretschmann configuration are measured and compared with simulations. The simulation also shows that the angular positions of resonances due to surface plasmon waves in reflectance spectrum are sensitive to the variation of principal refractive indices of helical films. It indicates that multiple surface plasmon waves at the [Ag/SiO2 helical thin film] interface is more attractive than the traditional method of producing only one surface plasmon wave for chemical- and bio-sensing applications.

  4. Refractive index gradient measurement across the thickness of a dielectric film by the prism coupling method

    A method is proposed for measuring the refractive index gradient n(z) in nonuniformly thick dielectric films. The method is based on the excitation of waveguide modes in a film using the prism coupling technique and on the calculation of n(z) and film thickness Hf with the help of the angular positions of the TE or TM modes. The method can be used for an arbitrary shape of the index modulation over the film thickness in the limit of a small gradient [Δ n(z)/n(z) || 1]. (laser applications and other topics in quantum electronics)

  5. PRISM (Polarized Radiation Imaging and Spectroscopy Mission): an extended white paper

    André, Philippe [Laboratoire d' Astrophysique de Paris-Saclay, Gif-sur-Yvette Cedex (France); Baccigalupi, Carlo; Bielewicz, Pawel [SISSA, Via Bonomea 265, 34136, Trieste (Italy); Banday, Anthony [Université de Toulouse, UPS-OMP, IRAP, F-31028 Toulouse cedex 4 (France); Barbosa, Domingos [Grupo de Radio Astronomia Basic Sciences and Enabling Technologies Instituto de Telecomunicações, Campus Universitario de Santiago, 3810-193 Aveiro (Portugal); Barreiro, Belen [Instituto de Fìsica de Cantabria (CSIC-Universidad de Cantabria) Avda. de los Castros s/n, 39005 Santander (Spain); Bartlett, James [APC, AstroParticule et Cosmologie, Université Paris Diderot, CNRS/IN2P3, CEA/lrfu, Observatoire de Paris, Sorbonne Paris, Cité, 10, rue Alice Domon et Léonie Duquet, 75205 Paris Cedex 13 (France); Bartolo, Nicola [Dipartimento di Fisica e Astronomia ' ' G. Galilei" , Università degli studi di Padova, via Marzolo 8, I-35131, Padova (Italy); Battistelli, Elia [Dipartimento di Fisica, Università di Roma La Sapienza, P.le A. Moro 2, 00185 Roma (Italy); Battye, Richard; Bonaldi, Anna [Jordell Bank Centre for Astrophysics, School of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL (United Kingdom); Bendo, George [U.K. ALMA Regional Centre Node, Jordell Bank Centre for Astrophysics, School of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL (United Kingdom); Benoȋt, Alain [Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL (United Kingdom); Bernard, Jean-Philippe [CNRS, IRAP, 9 Av. colonel Roche, BP 44346, F-31028 Toulouse cedex 4 (France); Bersanelli, Marco [Dipartimento di Fisica, Università degli Studi di Milano, Via Celoria, 16, Milano (Italy); Béthermin, Matthieu, E-mail: naselsky@nbi.dk [European Southern Observatory, Karl-Schwarzschild-Str. 2, 85748 Garching (Germany); and others

    2014-02-01

    PRISM (Polarized Radiation Imaging and Spectroscopy Mission) was proposed to ESA in May 2013 as a large-class mission for investigating within the framework of the ESA Cosmic Vision program a set of important scientific questions that require high resolution, high sensitivity, full-sky observations of the sky emission at wavelengths ranging from millimeter-wave to the far-infrared. PRISM's main objective is to explore the distant universe, probing cosmic history from very early times until now as well as the structures, distribution of matter, and velocity flows throughout our Hubble volume. PRISM will survey the full sky in a large number of frequency bands in both intensity and polarization and will measure the absolute spectrum of sky emission more than three orders of magnitude better than COBE FIRAS. The data obtained will allow us to precisely measure the absolute sky brightness and polarization of all the components of the sky emission in the observed frequency range, separating the primordial and extragalactic components cleanly from the galactic and zodiacal light emissions. The aim of this Extended White Paper is to provide a more detailed overview of the highlights of the new science that will be made possible by PRISM, which include: (1) the ultimate galaxy cluster survey using the Sunyaev-Zeldovich (SZ) effect, detecting approximately 10{sup 6} clusters extending to large redshift, including a characterization of the gas temperature of the brightest ones (through the relativistic corrections to the classic SZ template) as well as a peculiar velocity survey using the kinetic SZ effect that comprises our entire Hubble volume; (2) a detailed characterization of the properties and evolution of dusty galaxies, where the most of the star formation in the universe took place, the faintest population of which constitute the diffuse CIB (Cosmic Infrared Background); (3) a characterization of the B modes from primordial gravity waves generated during

  6. Compact surface plasmon resonance biosensor utilizing an injection-molded prism

    Chen, How-Foo; Chen, Chih-Han; Chang, Yun-Hsiang; Chuang, Hsin-Yuan

    2016-05-01

    Targeting at a low cost and accessible diagnostic device in clinical practice, a compact surface plasmon resonance (SPR) biosensor with a large dynamic range in high sensitivity is designed to satisfy commercial needs in food safety, environmental bio-pollution monitoring, and fast clinical diagnosis. The core component integrates an optical coupler, a sample-loading plate, and angle-tuning reflectors is injection-molded as a free-from prism made of plastic optics. This design makes a matching-oil-free operation during operation. The disposability of this low-cost component ensures testing or diagnosis without cross contamination in bio-samples.

  7. Single negative birefringence in stacked spoof plasmon metasurfaces by prism experiment.

    Beruete, M; Navarro-Cía, M; Falcone, F; Campillo, I; Sorolla, M

    2010-03-01

    We report negative and positive refraction in a prism made of stacked perforated thin surfaces for s and p polarization, respectively. By corrugating the subwavelength slits of a free-standing periodic arrangement, geometrically induced surface-plasmon-like currents are excited and transmission is allowed under s polarization (electric-field vector parallel to the slit). When several of those corrugated slit arrays are subwavelength stacked, the stack behaves as a negative effective index medium (because of double negativity) under s polarization, whereas it behaves as a positive effective index medium under p polarization. The birefringence has been confirmed by the usual wedge experiment in the millimeter-wave range. PMID:20195305

  8. Pyridine ligand rotation in self-assembled trigonal prisms. Evidence for intracage solvent vapor bubbles

    Vacek, Jaroslav; Caskey, D. C.; Horinek, D.; Shoemaker, R. K.; Stang, P. J.; Michl, Josef

    2008-01-01

    Roč. 130, č. 24 (2008), s. 7629-7638. ISSN 0002-7863 R&D Projects: GA AV ČR IAA400550616; GA MŠk ME 857 Grant ostatní: NSF(US) CHE-0306720; NSF(US) CHE-0446688; NSF(US) OISE0532040; European Commission(XE) STRPNMP4-013880; European Commission(XE) MCRTNCT-2005019481 Institutional research plan: CEZ:AV0Z40550506 Keywords : role of bubbles * self assembly * trigonal prisms Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 8.091, year: 2008

  9. Indirect versus direct feedback in computer-based Prism Adaptation Therapy

    Wilms, Inge Linda; Rytter, Hana Malá

    2010-01-01

    Prism Adaptation Therapy (PAT) is an intervention method in the treatment of the attention disorder neglect (Frassinetti, Angeli, Meneghello, Avanzi, & Ladavas, 2002; Rossetti, et al., 1998). The aim of this study was to investigate whether one session of PAT using a computer-attached touchscreen...... would produce similar aftereffects as the conventional physical box normally used in PAT. In four experiments, 81 healthy subjects and 7 brain-injured patients diagnosed with neglect were subjected to a single session of PAT under two conditions: 1) using the original physical box, 2) using a computer...

  10.   Indirect versus direct feedback in computer-based Prism Adaptation Therapy

    Wilms, Inge Linda; Rytter, Hana Malá

    2010-01-01

      Prism Adaptation Therapy (PAT) is an intervention method in the treatment of the attention disorder neglect (Frassinetti, Angeli, Meneghello, Avanzi, & Ladavas, 2002; Rossetti, et al., 1998). The aim of this study was to investigate whether one session of PAT using a computer-attached touchscreen...... would produce similar aftereffects as the conventional physical box normally used in PAT.   In four experiments, 81 healthy subjects and 7 brain-injured patients diagnosed with neglect were subjected to a single session of PAT under two conditions: 1) using the original physical box, 2) using a computer...

  11. HBsAg seroconversion after pegylated interferon alfa 2a rescue in a lamivudine-resistant patient with HBeAg-negative chronic hepatitis B and favourable IL28-B genotype.

    Stanzione, Maria; Stornaiuolo, Gianfranca; Rizzo, Viviana; Pontarelli, Agostina; Gaeta, Giovanni Battista

    2016-06-01

    Hepatitis B virus (HBV) surface antigen (HBsAg) seroconversion to anti-HBs antibody is the best final objective for all available chronic hepatitis B (CHB) treatments. Unfortunately, this goal is rarely achieved with the currently applied therapeutic approaches. Here we describe the case of an anti-HBe-positive CHB patient who was successfully treated with a particular therapeutic schedule. The patient was initially treated with lamivudine (LAM) for nine years. Breakthrough was observed after eight years of LAM therapy. HBV-DNA was 3x10E4 IU/mL and LAM resistance mutations were present. Subcutaneous pegylated interferon (PEG-IFN) alfa 2a, 180 mcg/week, was added to LAM and after 4 weeks LAM was discontinued and PEG-IFN alone was continued up to week 52. HBV-DNA became undetectable at week 4 of therapy; serum HBsAg started to decline from week 4 and became undetectable at week 36, with the subsequent appearance of anti-HBs antibodies. IL28-B was genotyped at the polymorphic site rs12979860 and the CC allele was detected. Rescue therapy with Peg-IFN may be an option for selected patients with resistance to nucleos(t)ide analogues. PMID:27367326

  12. Observation on immune effect of hepatitis B vaccine in infants born to HBsAg positive mothers%HBsAg阳性母亲的婴儿乙肝疫苗免疫效果观察

    丰淑英

    2011-01-01

    目的 比较HBsAg阳性母亲所生婴儿接种不同剂量乙肝疫苗后的免疫效果.方法 将HBsAg阳性母亲所生婴儿118例根据知情、自愿原则分为两组,每组59例.分别接种10 μg重组酵母乙肝疫苗和20 μg重组CHO(中国仓鼠卵巢细胞)乙肝疫苗,检测婴儿出生和12月龄时HBsAg和抗-HBs水平,比较不同剂量疫苗免疫后阻断乙肝病毒母婴传播效果.结果 婴儿出生时,接种10 μg和20 μg乙肝疫苗组婴儿HBsAg阳性率分别为8.47%和5.08%,差异无统计学意义.12月龄随访时,接种10 μg和20 μg乙肝疫苗的婴儿HBsAg阳性率分别为3.4%和1.7%,抗-HBs阳性率分别为83.1%和88.1%,差异无统计学意义;10 μg乙肝疫苗组婴儿抗-HBs无/弱应答率高于20 μg组婴儿,差异具有统计学意义(52.5% vs 33.9%,P<0.05).结论 20 μg乙肝疫苗免疫效果优于10 μg乙肝疫苗,对于母亲HBsAg阳性的婴儿,建议接种20 μg乙肝疫苗.%Objective To investigate the immune effect of different dosages of hepatitis B( HB ) vaccine in infants born to HBsAg positive mothers. Methods A total of 118 infants born to HBsAg positive mothers were divided into two groups,and were immunized with recombinant yeast-derived hepatitis B vaccines( 10 μg )or recombinant CHO cell derived hepatitis B vaccines( 20 g ), respectively. The HBsAg and anti-HBs were detected. The blocking effects of different doses of vaccine on mother-to-infant transmission of hepatitis B virus were compared. Results When the infants were born,HBsAg positive rate were 8.47% and 5.08% in 10 μg group and 20 μg group, respectively, and there was no significant difference between 2 groups. When the infants were 12 months old, HBsAg and antiHBs positive rates were not statistically significant between 2 groups, but the non( low )-responsive rate in 10 μg group was significantly higher than that in 20 μg group( P < 0.05 ). Conclusion The immune effect of 20 μg vaccine is better than that of 10 μg vaccine

  13. Hollow optical-fiber based infrared spectroscopy for measurement of blood glucose level by using multi-reflection prism.

    Kino, Saiko; Omori, Suguru; Katagiri, Takashi; Matsuura, Yuji

    2016-02-01

    A mid-infrared attenuated total reflection (ATR) spectroscopy system employing hollow optical fibers and a trapezoidal multi-reflection ATR prism has been developed to measure blood glucose levels. Using a multi-reflection prism brought about higher sensitivity, and the flat and wide contact surface of the prism resulted in higher measurement reproducibility. An analysis of in vivo measurements of human inner lip mucosa revealed clear signatures of glucose in the difference spectra between ones taken during the fasting state and ones taken after ingestion of glucose solutions. A calibration plot based on the absorption peak at 1155 cm(-1) that originates from the pyranose ring structure of glucose gave measurement errors less than 20%. PMID:26977373

  14. THE PRISM MULTI-OBJECT SURVEY (PRIMUS). II. DATA REDUCTION AND REDSHIFT FITTING

    Cool, Richard J. [MMT Observatory, Tucson, AZ 85721 (United States); Moustakas, John [Department of Physics, Siena College, 515 Loudon Rd., Loudonville, NY 12211 (United States); Blanton, Michael R.; Hogg, David W. [Center for Cosmology and Particle Physics, Department of Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); Burles, Scott M. [D.E. Shaw and Co. L.P, 20400 Stevens Creek Blvd., Suite 850, Cupertino, CA 95014 (United States); Coil, Alison L.; Aird, James; Mendez, Alexander J. [Department of Physics, Center for Astrophysics and Space Sciences, University of California, 9500 Gilman Dr., La Jolla, San Diego, CA 92093 (United States); Eisenstein, Daniel J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden St, MS 20, Cambridge, MA 02138 (United States); Wong, Kenneth C. [Steward Observatory, The University of Arizona, 933 N. Cherry Ave., Tucson, AZ 85721 (United States); Zhu, Guangtun [Center for Astrophysical Sciences, Department of Physics and Astronomy, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 (United States); Bernstein, Rebecca A. [Department of Astronomy and Astrophysics, UCA/Lick Observatory, University of California, 1156 High Street, Santa Cruz, CA 95064 (United States); Bolton, Adam S. [Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112 (United States)

    2013-04-20

    The PRIsm MUlti-object Survey (PRIMUS) is a spectroscopic galaxy redshift survey to z {approx} 1 completed with a low-dispersion prism and slitmasks allowing for simultaneous observations of {approx}2500 objects over 0.18 deg{sup 2}. The final PRIMUS catalog includes {approx}130,000 robust redshifts over 9.1 deg{sup 2}. In this paper, we summarize the PRIMUS observational strategy and present the data reduction details used to measure redshifts, redshift precision, and survey completeness. The survey motivation, observational techniques, fields, target selection, slitmask design, and observations are presented in Coil et al. Comparisons to existing higher-resolution spectroscopic measurements show a typical precision of {sigma}{sub z}/(1 + z) = 0.005. PRIMUS, both in area and number of redshifts, is the largest faint galaxy redshift survey completed to date and is allowing for precise measurements of the relationship between active galactic nuclei and their hosts, the effects of environment on galaxy evolution, and the build up of galactic systems over the latter half of cosmic history.

  15. Optical system design of the snapshot imaging spectrometerusing image replication based on Wollaston prism

    Pei, Lin-lin; Min, Huang; Lv, Qun-bo; Wang, Jian-wei; Li, Wei-yan

    2015-01-01

    Imaging spectral is a novel detection approach which simultaneously acquires two-dimensional visual picture and one-dimensional spectral information.The imaging spectrometer not only provides abundant data for aeronautics and astronautics remote sensing, but also offers promising applications on biomedical imaging, conservation and identification of art works,surveillance of food safety,prevention and control of plant diseases and elimination of pests,and so forth. In this paper, the snapshot imaging spectrometer using image replication based on Wollaston prisms is designed. This system includes the telescope objective, the collimator lens, the wave plates, Wollaston prisms, and the imaging lens.The imaging spectrometer system based on multi-configuration can obtain a high diffraction efficiency. Every configuration provide a kind of wave. The 16 configurations are in one mechanical structure. The system's MTF at 56 line pairs is better than 0.75. The RMS of the spots are all in one pixel.The imaging spectrometer can obtain perfect data.

  16. A beam-displacement prism based, three band stellar photo-polarimeter

    Raveendran, A V; Muneer, S; Mekkaden, M V; Jayavel, N; Somashekar, M R; Sagayanathan, K; Ramamoorthy, S; Rosario, M J; Jayakumar, K

    2015-01-01

    A new astronomical photo-polarimeter that can measure linear polarization of point sources simultaneously in three spectral bands was designed and built in Indian Institute of Astrophysics. The polarimeter has a Calcite beam-displacement prism as the analyzer. The ordinary and extra-ordinary emerging beams in each spectral band are quasi-simultaneously detected by the same photomultiplier by using a high speed rotating chopper. The effective chopping frequency can be set to as high as 200 Hz. A rotating superachromatic Pancharatnam halfwave plate is used to modulate the light incident on the analyzer. The spectral bands are isolated using appropriate dichroic and glass filters. A detailed analysis shows that the reduction of 50% in the efficiency of the polarimeter because of the fact that the intensities of the two beams are measured alternately is partly compensated by the reduced time to be spent on the observation of the sky background. The position angle of polarization produced by the Glan-Taylor prism ...

  17. Polygonal Prism Mesh in the Viscous Layers for the Polyhedral Mesh Generator, PolyGen

    Polyhedral mesh has been known to have some benefits over the tetrahedral mesh. Efforts have been made to set up a polyhedral mesh generation system with open source programs SALOME and TetGen. The evaluation has shown that the polyhedral mesh generation system is promising. But it is necessary to extend the capability of the system to handle the viscous layers to be a generalized mesh generator. A brief review to the previous works on the mesh generation for the viscous layers will be made in section 2. Several challenging issues for the polygonal prism mesh generation will be discussed as well. The procedure to generate a polygonal prism mesh will be discussed in detail in section 3. Conclusion will be followed in section 4. A procedure to generate meshes in the viscous layers with PolyGen has been successfully designed. But more efforts have to be exercised to find the best way for the generating meshes for viscous layers. Using the extrusion direction of the STL data will the first of the trials in the near future

  18. Use of a double-Wollaston prism laser differential interferometer in a plasma focus

    A double-Wollaston prism laser differential interferometer (LDI) has been developed to observe, for the first time, the evolution of the imploding current sheath (CS) and the high temperature and high density plasma pinch in the plasma focus. The light source is a Q-switched and frequency-doubled YAG laser operated in a single-pulse mode: λ=532 nm, the pulse width (FWHM) about 10 nm (also the resolution time of the LDI). The LDI measures density gradients and has a line sensitivity of about ne'=(2.58±0.46)x1025 m-4 for a typical sheath thickness of 1.6 mm and a minimum distinguishable fringe shift of 5%, and a spatial resolution of 1.26 mm. The density gradient and equivalent density of the CS are measured to be ne'∼(2.58±0.46)x1026 m-4 and ne∼(3.25±0.59)x1023 m-3, respectively. More importantly in this article, the double-Wollaston prism LDI, with a simple optical arrangement, gives direct physical pictures of the high density gradient plasma configuration and structure which are of interest in studying the status of plasma motion. copyright 1997 American Institute of Physics

  19. THE PRISM MULTI-OBJECT SURVEY (PRIMUS). I. SURVEY OVERVIEW AND CHARACTERISTICS

    We present the PRIsm MUlti-object Survey (PRIMUS), a spectroscopic faint galaxy redshift survey to z ∼ 1. PRIMUS uses a low-dispersion prism and slitmasks to observe ∼2500 objects at once in a 0.18 deg2 field of view, using the Inamori Magellan Areal Camera and Spectrograph camera on the Magellan I Baade 6.5 m telescope at Las Campanas Observatory. PRIMUS covers a total of 9.1 deg2 of sky to a depth of iAB ∼ 23.5 in seven different deep, multi-wavelength fields that have coverage from the Galaxy Evolution Explorer, Spitzer, and either XMM or Chandra, as well as multiple-band optical and near-IR coverage. PRIMUS includes ∼130,000 robust redshifts of unique objects with a redshift precision of σz/(1 + z) ∼ 0.005. The redshift distribution peaks at z ∼ 0.6 and extends to z = 1.2 for galaxies and z = 5 for broad-line active galactic nuclei. The motivation, observational techniques, fields, target selection, slitmask design, and observations are presented here, with a brief summary of the redshift precision; a forthcoming paper presents the data reduction, redshift fitting, redshift confidence, and survey completeness. PRIMUS is the largest faint galaxy survey undertaken to date. The high targeting fraction (∼80%) and large survey size will allow for precise measures of galaxy properties and large-scale structure to z ∼ 1.

  20. THE PRISM MULTI-OBJECT SURVEY (PRIMUS). II. DATA REDUCTION AND REDSHIFT FITTING

    The PRIsm MUlti-object Survey (PRIMUS) is a spectroscopic galaxy redshift survey to z ∼ 1 completed with a low-dispersion prism and slitmasks allowing for simultaneous observations of ∼2500 objects over 0.18 deg2. The final PRIMUS catalog includes ∼130,000 robust redshifts over 9.1 deg2. In this paper, we summarize the PRIMUS observational strategy and present the data reduction details used to measure redshifts, redshift precision, and survey completeness. The survey motivation, observational techniques, fields, target selection, slitmask design, and observations are presented in Coil et al. Comparisons to existing higher-resolution spectroscopic measurements show a typical precision of σz/(1 + z) = 0.005. PRIMUS, both in area and number of redshifts, is the largest faint galaxy redshift survey completed to date and is allowing for precise measurements of the relationship between active galactic nuclei and their hosts, the effects of environment on galaxy evolution, and the build up of galactic systems over the latter half of cosmic history.

  1. The PRIsm MUlti-object Survey (PRIMUS). II. Data Reduction and Redshift Fitting

    Cool, Richard J; Blanton, Michael R; Burles, Scott M; Coil, Alison L; Eisenstein, Daniel J; Wong, Kenneth C; Zhu, Guangtun; Aird, James; Bernstein, Rebecca A; Bolton, Adam S; Hogg, David W; Mendez, Alexander J

    2013-01-01

    The PRIsm MUti-object Survey (PRIMUS) is a spectroscopic galaxy redshift survey to z~1 completed with a low-dispersion prism and slitmasks allowing for simultaneous observations of ~2,500 objects over 0.18 square degrees. The final PRIMUS catalog includes ~130,000 robust redshifts over 9.1 sq. deg. In this paper, we summarize the PRIMUS observational strategy and present the data reduction details used to measure redshifts, redshift precision, and survey completeness. The survey motivation, observational techniques, fields, target selection, slitmask design, and observations are presented in Coil et al 2010. Comparisons to existing higher-resolution spectroscopic measurements show a typical precision of sigma_z/(1+z)=0.005. PRIMUS, both in area and number of redshifts, is the largest faint galaxy redshift survey completed to date and is allowing for precise measurements of the relationship between AGNs and their hosts, the effects of environment on galaxy evolution, and the build up of galactic systems over t...

  2. 2D Numerical Simulation of Fluid Flow over a Rectangular Prism

    Kaustubh Ravindra Bhat

    2009-08-01

    Full Text Available

    This paper is a part of an elaborate research involving simulation and practical testing of flows across solid objects. The research presented here deals with only the numerical modelling of such flows by development of code specifically for this purpose. The objective of this paper is to model the unsteady flow of incompressible fluid across a rectangular prism using simple collocated grid arrangement for Navier-Stokes Equation. The flow has been modelled numerically and flow visualizations have been generated for increasing values of Reynolds Number for a fluid at high kinematic viscosity. These results have been validated against previously probed values of the Strouhal Number versus the Reynolds Number. Also, an investigation has been made into the flow characteristics of a fluid at low kinematic viscosity in comparison with the highly viscous fluid at the same Reynolds Number. The simulations have been performed at low values of Reynolds Number. A prism of unit depth was chosen. The numerical investigation provides substantial information regarding the vortex shedding characteristics with increasing values of Reynolds Number.

  3. On testing violations of Bose and $CPT$ symmetries via Dalitz plots and Dalitz `prism'

    Sahoo, Dibyakrupa; Deshpande, N G

    2014-01-01

    Bose symmetry and $CPT$ symmetry are two very fundamental symmetries of Nature. However, the validity of these symmetries in diverse phenomena must be verified by experiments. We propose new techniques to probe these two fundamental symmetries in the realm of mesons by using the Dalitz plot of a few three-body meson decays. Since these symmetries are very fundamental in nature, their violations, if any, are expected to be extremely small. Hence observing their violations requires study of a huge data sample. In this context we introduce a new three-dimensional plot which we refer to as the Dalitz 'prism'. This provides an innovative means for acquiring the huge statistics required for such studies. Using the Dalitz plots and the Dalitz prisms we chart out the way to probe the violations of Bose and $CPT$ symmetries in a significant manner. Since mesons are unstable and composite particles, testing the validity of Bose symmetry and the $CPT$ symmetry in these cases are of paramount importance for fundamental p...

  4. Morphine enhances the release of /sup 3/H-purines from rat brain cerebral cortical prisms

    Wu, P.H.; Phillis, J.W.; Yuen, H.

    1982-10-01

    In vitro experiments have shown that /sup 3/H-purines can be released from /sup 3/H-adenosine preloaded rat brain cortical prisms by a KCl-evoked depolarization. The KCl-evoked release of /sup 3/H-purines is dependent on the concentration of KCl present in the superfusate. At concentrations of 10(-7) approximately 10(-5)M morphine did not influence the basal release of /sup 3/H-purines from the prisms, although it enhanced the KCl-evoked release of /sup 3/H-purines. The enhancement of KCl-evoked /sup 3/H-purine release by morphine was concentration-dependent and was antagonized by naloxone, suggesting the involvement of opiate receptors. Uptake studies with rat brain cerebral cortical synaptosomes show that morphine is a very weak inhibitor of adenosine uptake. Comparisons with dipyridamole, a potent inhibitor of adenosine uptake, suggest that this low level of inhibition of the uptake did not contribute significantly to the release of /sup 3/H-purine by morphine seen in our experiments. It is therefore suggested that morphine enhances KCl-evoked /sup 3/H-purine release by an interaction with opiate receptors and that the resultant increase in extracellular purine (adenosine) levels may account for some of the actions of morphine.

  5. Morphine enhances the release of 3H-purines from rat brain cerebral cortical prisms

    In vitro experiments have shown that 3H-purines can be released from 3H-adenosine preloaded rat brain cortical prisms by a KCl-evoked depolarization. The KCl-evoked release of 3H-purines is dependent on the concentration of KCl present in the superfusate. At concentrations of 10(-7) approximately 10(-5)M morphine did not influence the basal release of 3H-purines from the prisms, although it enhanced the KCl-evoked release of 3H-purines. The enhancement of KCl-evoked 3H-purine release by morphine was concentration-dependent and was antagonized by naloxone, suggesting the involvement of opiate receptors. Uptake studies with rat brain cerebral cortical synaptosomes show that morphine is a very weak inhibitor of adenosine uptake. Comparisons with dipyridamole, a potent inhibitor of adenosine uptake, suggest that this low level of inhibition of the uptake did not contribute significantly to the release of 3H-purine by morphine seen in our experiments. It is therefore suggested that morphine enhances KCl-evoked 3H-purine release by an interaction with opiate receptors and that the resultant increase in extracellular purine (adenosine) levels may account for some of the actions of morphine

  6. Porosity-formation factor and porosity-velocity relationships in Barbados prism

    Erickson, Stephanie N.; Jarrard, Richard D.

    1999-07-01

    Ocean Drilling Program Leg 171A collected logging while drilling (LWD) data to investigate the porosity and velocity structure of Barbados accretionary complex. Porosity and velocity measurements were needed for interpretation of prism dynamics. However, the LWD tool string did not measure velocity, and previous velocity data from Barbados prism are scarce and generally of low quality. Furthermore, most density-based porosities are subject to errors associated with variations in smectite content. To determine porosities more accurately, we use smectite-corrected, density-based porosities to calibrate a porosity-formation factor (FF) transform, then calculate porosities from resistivity logs. We used cation exchange capacity (CEC) measurements and LWD logs to evaluate the possibility that resistivity is affected by clay conduction. The CEC data warn of potential clay conduction, especially in smectite-rich zones, but LWD data indicate that clay conduction is minor in these high-porosity sediments. Instead, tortuosity is the secondary control of FF, after porosity. By comparing resistivity-based porosities to velocities from vertical seismic profiles, we determine a porosity-velocity transform applicable to Barbados. We then use this transform to calculate velocity logs from resistivity-based porosity logs.

  7. Seasonal variation of tidal prism and energy in the Changjiang River estuary: a numerical study

    Zhang, Min; Townend, Ian Howard; Cai, Huayang; Zhou, Yunxuan

    2016-01-01

    Tidal rivers are intrinsically complex because tidal propagation is influenced by river discharge. This study aims to examine the seasonal variation of tidal prism and energy variance in the tidal river of the Changjiang (Yangtze) River estuary in China. In order to quantify the behaviour of river and tide, we use numerical modelling that has been validated using measured data. We conduct our analysis by quantifying the discharge and energy variance in separate components for both the river and the tide, during wet and dry seasons. We note various definitions of tidal prism and explore the difference between tidal discharge on the flood and ebb and tidal storage volume. The results show that the river discharge attenuates the tidal motion and reduces the tidal flood discharge but the tidal storage volume is approximately constant with different riverine discharge since part of the fresh water discharge is intercepted and captured in the estuary due to the backwater effect. It appears that the tidal discharge adjusts according to the variation of river discharge to keep a constant tidal storage volume. An analysis of the hydraulics shows that the transition from tidal dominance (at the mouth) to river dominance (upstream) depends on the location of tidal current reversal which varies from wet season to dry season. Duringthe wet season, the Changjiang River estuary is totally dominated by energy from fresh water discharge.

  8. FDS5 Simulation for OECD PRISME Fire Test of DOOR PRSD5

    OECD/NEA PRISME Fire Project is an international co-operation project to investigate fire propagation by means of experiments and analyses for nuclear power plant applications. This project focuses on the generation of experimental data for fire and smoke propagation from the fire room to adjacent rooms under various conditions and room configurations. In addition, analyses using computer codes are performed to understand the phenomena of interest and to produce a consistent interpretation of the experimental results. The PRISME Project is composed of series of tests named as SOURCE, DOOR, LEAK and Global Tests. The SOURCE is composed of tests to characterize the fire source, and the DOOR is to study fire and smoke propagation through an open door, while the LEAK is to investigate hot gas leakages through other modes of openings such as holes, a slot, a duct, and a partially opened door. The Global test will be conducted as integral tests on the basis of the results of the previous separate effects tests. In this paper, simulations are performed with FDS5 computer code for the DOOR Test No.5 (PRSD5) and the calculation results are compared with the corresponding experimental data to study the code capability to predict the phenomena of the hot gas propagation between two rooms

  9. Hard x-ray holographic microscopy using refractive prism and Fresnel zone plate objective

    An optics for hard x-ray holographic microscopy has been developed and preliminary experiments have been done at SPring-8 undulator beamline 20XU. The optical system consists of an x-ray objective lens (Fresnel zone plate) and a wave front-division-type interferometer with prism optics. The illuminating x-ray beam is coherent with parallel radiation, and the spatially coherent area is much larger than the aperture of the objective lens. The refractive prism is placed behind the back focal plane of the objective lens in order to configure the wavefront-dividing interferometer. Half of the illuminating radiation is used for illuminating an object, and the other half is used for forming a reference wave. The magnified image of the object is generated at an image plane, and the reference wave is superimposed on the magnified image of the object. The recorded interferogram includes both amplitude and phase information of the object. The spatial resolution is determined by the numerical aperture of the objective lens. Therefore, in principle, this method enables holographic imaging at nanometer scale to be carried out in the hard x-ray region

  10. Reading performance is not affected by a prism induced increase of horizontal and vertical vergence demand

    Muriel eDysli

    2014-06-01

    Full Text Available Purpose Dyslexia is the most common developmental reading disorder that affects language skills. Latent strabismus (heterophoria has been suspected to be causally involved. Even though phoria correction in dyslexic children is commonly applied, the evidence in support of a benefit is poor. In order to provide experimental evidence on this issue, we simulated phoria in healthy readers by modifying the vergence tone required to maintain binocular alignment. MethodsVergence tone was altered with prisms that were placed in front of one eye in 16 healthy subjects to induce exophoria, esophoria, or vertical phoria. Subjects were to read one paragraph for each condition, from which reading speed was determined. Text comprehension was tested with a forced multiple choice test. Eye movements were recorded during reading and subsequently analysed for saccadic amplitudes, saccades per 10 letters, percentage of regressive (backward saccades, average fixation duration, first fixation duration on a word, and gaze duration.ResultsAcute change of horizontal and vertical vergence tone does neither significantly affect reading performance nor reading associated eye movements. Conclusion Prisms in healthy subjects fail to induce a significant change of reading performance. This finding is not compatible with a role of phoria in dyslexia. Our results contrast the proposal for correcting small angle heterophorias in dyslexic children.

  11. Calibration of miniature prism-based stereoscopic imagers for precise spatial measurements

    Machikhin, Alexander S.; Gorevoy, Alexey V.

    2016-04-01

    The paper is targeted to find the optimal mathematical model and the calibration algorithm for the industrial endoscope equipped with the prism-based attachable stereo adapter, which allows imaging from two different points by a single sensor. We consider the conventional calibration methods for the pinhole camera model with polynomial distortion approximation and compared them with the ray tracing model based on the vector form of Snell's law. In order to evaluate each of the proposed models we have developed the software for the imitation of various calibration procedures using different types of calibration targets. We use the computer simulation to prove that the pinhole camera models, widely used in machine vision, are very limited for describing prism-based endoscopic measurement systems. Our analysis identified the main problems for these models, such as entrance pupil shift, non-homocentric beams and required number of coefficients for polynomial models and the iterative forward ray aiming for the ray-tracing model. The proposed technique is flexible and can also be used to test stability and convergence of the parameter estimation procedures and to compare calibration targets and strategies.

  12. SISTEM PENGUKURAN KINERJA DENGAN METODE PERFORMANCE PRISM (Studi Kasus di RUMAH SAKIT ISLAM SULTAN AGUNG SEMARANG

    Heru Prastawa

    2012-02-01

    Full Text Available Sultan Agung Islamic Hospital Semarang is a healthcare institution owned by Yayasan Badan Wakaf SultanAgung. To survive against the competitors, the hospital must have a good performance. Thus, a properperformance measurement system is required to assist the company in informing the hospital, so they know howfar has their effort worked in achieving the company’s vision and mission, including to analyze how far has thecompany developed. The researcher intends to design a performance measurement system using theperformance prism method at Sultan Agung Islamic Hospital Semarang. Designing a performance measurementsystem by implementing the performance prism method is sequenced by several phases. Firstly, identify thesatisfaction and stakeholder’s contribution, strategy identification phase, process, and capability, KeyPerformance Indicator (KPI identification phase, weighing KPI by Analytical Hierarchy Process (AHP phase,achieving performance targets by an Objective Matrix (OMAX phase, and the calculation phase of performancevalue in numbers. After we calculate the weighed KPI and performance value, a simulation is conducted to knowthe criteria and KPI elements that is prioritized a suggestion, improvement recommendation that could beapplied to enhance the performance of Sultan Agung Islamic Hospital Semarang

  13. ANALISIS PENGUKURAN KINERJA PERUSAHAAN DENGAN METODE PERFORMANCE PRISM DAN SCORING OBJECTIVE MATRIX (OMAX PADA PT. BPAS

    Adianto .

    2014-06-01

    Full Text Available Kinerja merupakan suatu tampilan keadaan secara utuh atas perusahaan selama periode waktu tertentu. PT. BPAS adalah sebuah perusahaan yang bergerak dalam bidang industri papan semen. Selama ini sistem pengukuran kinerja di PT. BPAS belum merepresentasikan kinerja organisasi secara komprehensif dan integratif. Oleh sebab itu pengukuran kinerja perlu dilakukan pada PT. BPAS dengan menggunakan metode Performance Prism dan Scoring OMAX agar dapat meningkatkan kinerja perusahaan secara maksimal. Performance Prism merupakan pengukuran yang terintegrasi, meliputi seluruh aspek perusahaan (stakeholder yang menyangkut kepuasan stakeholder dan kontribusi stakeholder, strategi, proses dan kapabilitas kepada perusahaan. Pengukuran kinerja dalam penelitian ini akan dilakukan secara bertahap dengan menggunakan beberapa metode antara lain pembobotan dengan Analytical Hierachy Process (AHP untuk mengetahui skala nilai prioritas setiap KPI, Scoring System dengan metode Objectives Matrix (OMAX dan Traffic Light System untuk mengetahui level setiap KPI pada perusahaan di tingkat korporasi. Dari hasil pengukuran kinerja pada PT. BPAS terdapat 16 KPI yang telah sesuai dengan harapan, 19 KPI yang masih memiliki performa yang cukup namun perlu diperhatikan dan 5 KPI yang memiliki performa sangat rendah. Sehingga didapatkan kesimpulan yaitu perusahaan perlu memperbaiki 5 KPI kinerja agar perusahaan dapat meningkatkan keseluruhan kinerjanya secara maksimal.

  14. Rapid growth of ZnO hexagonal prism crystals by direct microwave heating

    ZHU Zhenqi; ZHOU Jian; LIU Guizhen; REN Zhiguo

    2008-01-01

    ZnO hexagonal prism crystals were synthesized from ZnO powders by microwave heating in a short time (within 20 min) without any metal catalyst or transport agent.Zinc oxide raw materials were made by evaporating from the high-temperature zone in an enclosure atmosphere and crystals were grown on the self-source substrate.The inherent asymmetry in microwave heating provides the temperature gradient for crystal growth.Substrate and temperature distribution in the oven show significant effects on the growth of the ZnO crystal.The morphologies demonstrate that these samples are pure hexagonal prism crystals with maximum 80 μm in diameter and 600 μm in length,which possess a well faceted end and side surface.X-ray diffraction (XRD) reveals that these samples are pure crystals.The photoluminescence (PL) exhibits strong ultraviolet emission at room temperature,indicating potential applications for short-wave light-emitting photonic devices.

  15. Cerebellar cathodal tDCS interferes with recalibration and spatial realignment during prism adaptation procedure in healthy subjects.

    Panico, Francesco; Sagliano, Laura; Grossi, Dario; Trojano, Luigi

    2016-06-01

    The aim of this study is to clarify the specific role of the cerebellum during prism adaptation procedure (PAP), considering its involvement in early prism exposure (i.e., in the recalibration process) and in post-exposure phase (i.e., in the after-effect, related to spatial realignment). For this purpose we interfered with cerebellar activity by means of cathodal transcranial direct current stimulation (tDCS), while young healthy individuals were asked to perform a pointing task on a touch screen before, during and after wearing base-left prism glasses. The distance from the target dot in each trial (in terms of pixels) on horizontal and vertical axes was recorded and served as an index of accuracy. Results on horizontal axis, that was shifted by prism glasses, revealed that participants who received cathodal stimulation showed increased rightward deviation from the actual position of the target while wearing prisms and a larger leftward deviation from the target after prisms removal. Results on vertical axis, in which no shift was induced, revealed a general trend in the two groups to improve accuracy through the different phases of the task, and a trend, more visible in cathodal stimulated participants, to worsen accuracy from the first to the last movements in each phase. Data on horizontal axis allow to confirm that the cerebellum is involved in all stages of PAP, contributing to early strategic recalibration process, as well as to spatial realignment. On vertical axis, the improving performance across the different stages of the task and the worsening accuracy within each task phase can be ascribed, respectively, to a learning process and to the task-related fatigue. PMID:27031676

  16. Antibody-free PRISM-SRM for multiplexed protein quantification: Is this the new competition for immunoassays in bioanalysis?

    Shi, Tujin; Qian, Weijun

    2013-02-01

    Highly sensitive technologies for multiplexed quantification of a large number of candidate proteins will play an increasingly important role in clinical biomarker discovery, systems biology, and general biomedical research. Herein we introduce the new PRISM-SRM technology, which represents a highly sensitive multiplexed quantification technology capable of simultaneous quantification of many low-abundance proteins without the need of affinity reagents. The versatility of antibody-free PRISM-SRM for quantifying various types of targets including protein isoforms, protein modifications, metabolites, and others, thus offering new competition with immunoassays.

  17. X-ray holographic microscopy with Fresnel zone plate objective lens and double-diamond-prism interferometer

    A hard X-ray imaging holography system with a Fresnel zone plate objective lens and double-diamond-prism interferometer has been developed. The refractive prism made of single-crystal diamond is used for solving the radiation damage problem caused by high-flux-density X-ray beams. Uniform periodic interference fringes are observed, and a carrier fringe scan is carried out using a rotating thin glass plate as a phase shifter. Phase retrieval by the fringe scan method is also achieved with a suboptical spatial resolution. (author)

  18. Microwave Experimental Observation of Transmitted Enhanced Goos–Hänchen Displacement in Symmetry-Double-Prism Configuration

    It is theoretically proven that the transmitted Goos–Hänchen (GH) displacement in the symmetry-double prism could be resonantly enhanced when the incident angle is less than but near the critical angle, and is modulated by the slab thickness between two prisms and the incident angle. This enhancement effect is directly observed in microwave experiments in which the incident angle is properly chosen. The measured data are in good agreement with the result of the numerical simulation. (fundamental areas of phenomenology (including applications))

  19. Evaluating PRISM (Pictorial Representation of Illness and Self Measure) as a measure of life quality for children with skin diseases

    Melbardis Jørgensen, K.; Jemec, G.B.E.

    2011-01-01

    of age-dependant cognitive development on children's self-reported QoL. Methods and materials: A total of 43 children of both sexes aged 5-16, with a diagnosed dermatologic disease were asked to complete both PRISM and CDLQI. Children with a mental handicap, children who did not speak Danish or who......-verbal instrument may therefore be of particular relevance to pediatric patients. Purpose: To evaluate PRISM (Pictorial Representation of Illness and Self Measure) as a non-verbal measure of QoL for children with skin diseases compared to CDLQI (Children's Dermatology Life Quality Index) and the possible influence...

  20. A comparison of difference in psychological stress between normal pregnant women and HbsAg positive pregnant women%乙肝孕产妇与正常孕产妇心理变化及比较

    李亚萍; 郭新贤; 周文勤

    2011-01-01

    Objective To compare difference in psychological stress level between normal pregnant women and pregnant women with positive hepatitis B surface antigen (HbsAg). Methods 69 pregnant women with positive HbsAg (case group) and 123 normal pregnant women (control group) were randomly extracted from all pregnant women who delivered in outpatient or inpatient of Xi' an Municipal Central Hospital. The psychological status of the pregnant women in the two groups was assessed with Hamilton Rating Scale for Depression( HRSD), Hamilton Rating Scale for Anxiety(HAMA) and Symptom Checklist 90(SCL-90). Results Incidence rates of depression and anxiety in the case group were significantly higher than the control group (X2depression = 13. 487, X2anxiety = 53. 756, both P < 0. 01 ). There were no significant differences in all physical and psychological health indexes between the two groups ( all P > 0.05 ) except hostile symptom( t = - 2.513, P < 0.05). Conclusion The psychological stress level of those pregnant women with positive HbsAg is higher than the normal pregnant women, especially the incidence rates of moderate and severe depression and moderate and severe anxiety, although their main psychic reaction and emotional response and stages are consistent to those of the normal pregnant women.%目的 分析乙肝孕产妇与正常孕产妇的心理应激的差异.方法 随机抽取69名门诊或住院就诊的HbsAg(+)孕产妇(病例组),随机抽取同期具有可比性的正常妊娠妇女123例(对照组).采用汉密尔顿抑郁量表、汉密尔顿焦虑量表及症状自评量表评定HbsAg(+)孕产妇与正常妊娠妇女的心理状况.结果 病例组抑郁和焦虑的发生率均较对照组高,经比较有显著性差异(χ2抑郁=13.487,P0.05).结论 HbsAg(+)孕产妇的心理应激水平比正常孕妇更高,以中度、重度抑郁、焦虑最为显著;其主要心理情绪反应及阶段与正常孕妇基本一致.