WorldWideScience

Sample records for a-site finger revealed

  1. The PHD finger of human UHRF1 reveals a new subgroup of unmethylated histone H3 tail readers.

    Nada Lallous

    Full Text Available The human UHRF1 protein (ubiquitin-like containing PHD and RING finger domains 1 has emerged as a potential cancer target due to its implication in cell cycle regulation, maintenance of DNA methylation after replication and heterochromatin formation. UHRF1 functions as an adaptor protein that binds to histones and recruits histone modifying enzymes, like HDAC1 or G9a, which exert their action on chromatin. In this work, we show the binding specificity of the PHD finger of human UHRF1 (huUHRF1-PHD towards unmodified histone H3 N-terminal tail using native gel electrophoresis and isothermal titration calorimetry. We report the molecular basis of this interaction by determining the crystal structure of huUHRF1-PHD in complex with the histone H3 N-terminal tail. The structure reveals a new mode of histone recognition involving an extra conserved zinc finger preceding the conventional PHD finger region. This additional zinc finger forms part of a large surface cavity that accommodates the side chain of the histone H3 lysine K4 (H3K4 regardless of its methylation state. Mutation of Q330, which specifically interacts with H3K4, to alanine has no effect on the binding, suggesting a loose interaction between huUHRF1-PHD and H3K4. On the other hand, the recognition appears to rely on histone H3R2, which fits snugly into a groove on the protein and makes tight interactions with the conserved aspartates D334 and D337. Indeed, a mutation of the former aspartate disrupts the formation of the complex, while mutating the latter decreases the binding affinity nine-fold.

  2. Structural dynamics of elbow segment of E.coli ribosomal A-site finger. Comparison of simulations with cryo-EM data and with equivalent segments in other species

    Réblová, Kamila; Rázga, Filip; Li, W.; Gao, H.; Frank, J.; Šponer, Jiří

    2009-01-01

    Roč. 26, č. 6 (2009), s. 793. ISSN 0739-1102. [The 17th Conversation. 16.06.2009-20.06.2009, Albany] Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702 Keywords : E. coli * A-site finger Subject RIV: BO - Biophysics

  3. Minimal promoter systems reveal the importance of conserved residues in the B-finger of human transcription factor IIB.

    Thompson, Nancy E; Glaser, Bryan T; Foley, Katherine M; Burton, Zachary F; Burgess, Richard R

    2009-09-11

    The "B-finger" of transcription factor IIB (TFIIB) is highly conserved and believed to play a role in the initiation process. We performed alanine substitutions across the B-finger of human TFIIB, made change-of-charge mutations in selected residues, and substituted the B-finger sequence from other organisms. Mutant proteins were examined in two minimal promoter systems (containing only RNA polymerase II, TATA-binding protein, and TFIIB) and in a complex system, using TFIIB-immunodepleted HeLa cell nuclear extract (NE). Mutations in conserved residues located on the sides of the B-finger had the greatest effect on activity in both minimal promoter systems, with mutations in residues Glu-51 and Arg-66 eliminating activity. The double change-of-charge mutant (E51R:R66E) did not show activity in either minimal promoter system. Mutations in the nonconserved residues at the tip of the B-finger did not significantly affect activity. However, all of the mutations in the B-finger showed at least 25% activity in the HeLa cell NE. Chimeric proteins, containing B-finger sequences from species with conserved residues on the side of the B-finger, showed wild-type activity in a minimal promoter system and in the HeLa cell NE. However, chimeric proteins whose sequence showed divergence on the sides of the B-finger had reduced activity. Transcription factor IIF (TFIIF) partially restored activity of the inactive mutants in the minimal promoter system, suggesting that TFIIF in HeLa cell NE helps to rescue the inactive mutations by interacting with either the B-finger or another component of the initiation complex that is influenced by the B-finger. PMID:19590095

  4. Finger pain

    Pain - finger ... Nearly everyone has had finger pain at some time. You may have: Tenderness Burning Stiffness Numbness Tingling Coldness Swelling Change in skin color Redness Many conditions, such ...

  5. Minimal Promoter Systems Reveal the Importance of Conserved Residues in the B-finger of Human Transcription Factor IIB*

    Thompson, Nancy E.; GLASER, BRYAN T.; Foley, Katherine M.; Burton, Zachary F.; Burgess, Richard R.

    2009-01-01

    The “B-finger” of transcription factor IIB (TFIIB) is highly conserved and believed to play a role in the initiation process. We performed alanine substitutions across the B-finger of human TFIIB, made change-of-charge mutations in selected residues, and substituted the B-finger sequence from other organisms. Mutant proteins were examined in two minimal promoter systems (containing only RNA polymerase II, TATA-binding protein, and TFIIB) and in a complex system, using TFIIB-immunodepleted HeL...

  6. Zinc finger proteins in cancer progression

    Jen, Jayu; Wang, Yi-Ching

    2016-01-01

    Zinc finger proteins are the largest transcription factor family in human genome. The diverse combinations and functions of zinc finger motifs make zinc finger proteins versatile in biological processes, including development, differentiation, metabolism and autophagy. Over the last few decades, increasing evidence reveals the potential roles of zinc finger proteins in cancer progression. However, the underlying mechanisms of zinc finger proteins in cancer progression vary in different cancer...

  7. Small perturbations in a finger-tapping task reveal inherent nonlinearities of the underlying error correction mechanism.

    Bavassi, M Luz; Tagliazucchi, Enzo; Laje, Rodrigo

    2013-02-01

    Time processing in the few hundred milliseconds range is involved in the human skill of sensorimotor synchronization, like playing music in an ensemble or finger tapping to an external beat. In finger tapping, a mechanistic explanation in biologically plausible terms of how the brain achieves synchronization is still missing despite considerable research. In this work we show that nonlinear effects are important for the recovery of synchronization following a perturbation (a step change in stimulus period), even for perturbation magnitudes smaller than 10% of the period, which is well below the amount of perturbation needed to evoke other nonlinear effects like saturation. We build a nonlinear mathematical model for the error correction mechanism and test its predictions, and further propose a framework that allows us to unify the description of the three common types of perturbations. While previous authors have used two different model mechanisms for fitting different perturbation types, or have fitted different parameter value sets for different perturbation magnitudes, we propose the first unified description of the behavior following all perturbation types and magnitudes as the dynamical response of a compound model with fixed terms and a single set of parameter values. PMID:23375111

  8. Finger Stiffness

    Oosterhoff, Thijs C.H.; Nota, Sjoerd P. F. T.; Ring, David

    2014-01-01

    Background Finger stiffness varies substantially in patients with hand and upper extremity illness and can be notably more than expected for a given pathophysiology. In prior studies, pain intensity and magnitude of disability consistently correlate with coping strategies such as catastrophic thinking and kinesiophobia, which can be characterized as overprotectiveness. In this retrospective study we address the primary research question whether patients with finger stiffness are more often ov...

  9. Finger Stiffness.

    Oosterhoff, Thijs C H; Nota, Sjoerd P F T; Ring, David

    2015-06-01

    Background Finger stiffness varies substantially in patients with hand and upper extremity illness and can be notably more than expected for a given pathophysiology. In prior studies, pain intensity and magnitude of disability consistently correlate with coping strategies such as catastrophic thinking and kinesiophobia, which can be characterized as overprotectiveness. In this retrospective study we address the primary research question whether patients with finger stiffness are more often overprotective when the primary pathology is outside the hand (e.g. distal radius fracture) than when it is located within the hand. Methods In an orthopaedic hand surgery department 160 patients diagnosed with more finger stiffness than expected for a given pathophysiology or time point of recovery between December 2006 and September 2012 were analyzed to compare the proportion of patients characterized as overprotective for differences by site of pathology: (1) inside the hand, (2) outside the hand, and (3) psychiatric etiology (e.g. clenched fist). Results Among 160 subjects with more finger stiffness than expected, 132 (82 %) were characterized as overprotective including 88 of 108 (81 %) with pathology in the hand, 39 of 44 (89 %) with pathology outside the hand, and 5 of 8 (63 %) with psychiatric etiology. These differences were not significant. Conclusions Overprotectiveness is common in patients with more finger stiffness than expected regardless the site and type of primary pathology. It seems worthwhile to recognize and treat maladaptive coping strategies early during recovery to limit impairment, symptoms, and disability. PMID:26078497

  10. Finger pain

    ... and bruises Broken finger bones Skier's thumb , an injury to the ligaments in your thumb, such as from a fall ... health care provider. Small fractures or tendon or ligament tears ... have Raynaud's, take steps to protect your hands from the cold.

  11. Fingers phrase music differently: trial-to-trial variability in piano scale playing and auditory perception reveal motor chunking

    Floris Tijmen Van Vugt

    2012-11-01

    Full Text Available We investigated how musical phrasing and motor sequencing interact to yield timing patterns in the conservatory students' playing piano scales. We propose a novel analysis method that compared the measured note onsets to an objectively regular scale fitted to the data. Subsequently, we segment the timing variability into (i systematic deviations from objective evenness that are perhaps residuals of expressive timing or of perceptual biases and (ii non-systematic deviations that can be interpreted as motor execution errors, perhaps due to noise in the nervous system. The former, systematic deviations, reveal that the two octave scales are played as a single musical phrase. The latter, trial-to-trial variabilities reveal that pianists' timing was less consistent at the boundaries between the octaves, providing evidence that the octave is represented as a single motor sequence. These effects cannot be explained by low-level properties of the motor task such as the thumb-passage and also did not show up in simulated scales with temporal jitter. Intriguingly, this instability in motor production around the octave boundary is mirrored by an impairment in the detection of timing deviations at those positions, suggesting that chunks overlap between perception and action. We conclude that the octave boundary instability in the scale playing motor program provides behavioural evidence that our brain chunks musical sequences into octave units that do not coincide with musical phrases. Our results indicate that trial-to-trial variability is a novel and meaningful indicator of this chunking. The procedure can readily be extended to a variety of tasks to help understand how movements are divided into units and what processing occurs at their boundaries.

  12. Fingers Phrase Music Differently: Trial-to-Trial Variability in Piano Scale Playing and Auditory Perception Reveal Motor Chunking.

    van Vugt, Floris Tijmen; Jabusch, Hans-Christian; Altenmüller, Eckart

    2012-01-01

    We investigated how musical phrasing and motor sequencing interact to yield timing patterns in the conservatory students' playing piano scales. We propose a novel analysis method that compared the measured note onsets to an objectively regular scale fitted to the data. Subsequently, we segment the timing variability into (i) systematic deviations from objective evenness that are perhaps residuals of expressive timing or of perceptual biases and (ii) non-systematic deviations that can be interpreted as motor execution errors, perhaps due to noise in the nervous system. The former, systematic deviations reveal that the two-octave scales are played as a single musical phrase. The latter, trial-to-trial variabilities reveal that pianists' timing was less consistent at the boundaries between the octaves, providing evidence that the octave is represented as a single motor sequence. These effects cannot be explained by low-level properties of the motor task such as the thumb passage and also did not show up in simulated scales with temporal jitter. Intriguingly, this instability in motor production around the octave boundary is mirrored by an impairment in the detection of timing deviations at those positions, suggesting that chunks overlap between perception and action. We conclude that the octave boundary instability in the scale playing motor program provides behavioral evidence that our brain chunks musical sequences into octave units that do not coincide with musical phrases. Our results indicate that trial-to-trial variability is a novel and meaningful indicator of this chunking. The procedure can readily be extended to a variety of tasks to help understand how movements are divided into units and what processing occurs at their boundaries. PMID:23181040

  13. Stamen abscission zone transcriptome profiling reveals new candidates for abscission control: enhanced retention of floral organs in transgenic plants overexpressing Arabidopsis ZINC FINGER PROTEIN2.

    Cai, Suqin; Lashbrook, Coralie C

    2008-03-01

    Organ detachment requires cell separation within abscission zones (AZs). Physiological studies have established that ethylene and auxin contribute to cell separation control. Genetic analyses of abscission mutants have defined ethylene-independent detachment regulators. Functional genomic strategies leading to global understandings of abscission have awaited methods for isolating AZ cells of low abundance and very small size. Here, we couple laser capture microdissection of Arabidopsis thaliana stamen AZs and GeneChip profiling to reveal the AZ transcriptome responding to a developmental shedding cue. Analyses focus on 551 AZ genes (AZ(551)) regulated at the highest statistical significance (P Gene Ontology Consortium functional categories for cell wall modifying proteins, extracellular regulators, and nuclear-residing transcription factors. Promoter-beta-glucuronidase expression of one transcription factor candidate, ZINC FINGER PROTEIN2 (AtZFP2), was elevated in stamen, petal, and sepal AZs. Flower parts of transgenic lines overexpressing AtZFP2 exhibited asynchronous and delayed abscission. Abscission defects were accompanied by altered floral morphology limiting pollination and fertility. Hand-pollination restored transgenic fruit development but not the rapid abscission seen in wild-type plants, demonstrating that pollination does not assure normal rates of detachment. In wild-type stamen AZs, AtZFP2 is significantly up-regulated postanthesis. Phenotype data from transgene overexpression studies suggest that AtZFP2 participates in processes that directly or indirectly influence organ shed. PMID:18192438

  14. Trigger Finger (Stenosing Tenosynovitis)

    ... Symptom Picker Hand and Arm Conditions Carpal Tunnel Ganglion Cysts Trigger Finger Arthritis Base of the Thumb See ... Symptom Picker Hand and Arm Conditions Carpal Tunnel Ganglion Cysts Trigger Finger Arthritis Base of the Thumb See ...

  15. Perceiving fingers in single-digit arithmetic problems

    Ilaria eBerteletti

    2015-03-01

    Full Text Available In this study, we investigate in children the neural underpinnings of finger representation and finger movement involved in single-digit arithmetic problems. Evidence suggests that finger representation and finger-based strategies play an important role in learning and understanding arithmetic. Because different operations rely on different networks, we compared activation for subtraction and multiplication problems in independently localized finger somatosensory and motor areas and tested whether activation was related to skill. Brain activations from children between 8 and 13 years of age revealed that only subtraction problems significantly activated finger motor areas, suggesting reliance on finger-based strategies. In addition, larger subtraction problems yielded greater somatosensory activation than smaller problems, suggesting a greater reliance on finger representation for larger numerical values. Interestingly, better performance in subtraction problems was associated with lower activation in the finger somatosensory area. Our results support the importance of fine-grained finger representation in arithmetical skill and are the first neurological evidence for a functional role of the somatosensory finger area in proficient arithmetical problem solving, in particular for those problems requiring quantity manipulation. From an educational perspective, these results encourage investigating whether different finger-based strategies facilitate arithmetical understanding and encourage educational practices aiming at integrating finger representation and finger-based strategies as a tool for instilling stronger numerical sense.

  16. Cloning overlapping DNA fragments from the B95-8 strain of Epstein-Barr virus reveals a site of homology to the internal repetition.

    Buell, G N; Reisman, D; Kintner, C; Crouse, G; Sugden, B

    1981-01-01

    Overlapping, sheared DNA fragments from the B95-8 strain of Epstein-Barr virus were cloned in Charon 4A. Eleven recombinant phages plus one recombinant plasmid contained all of the sequences found in B95-8 virion DNA. Analysis of recombinant DNA molecules revealed a previously undetected site of homology to the internal repetition found in Epstein-Barr virus DNA. This site was adjacent to or at a site which was unstable when the recombinant DNA was propagated as phage DNA in procaryotic hosts.

  17. Structures of three members of Pfam PF02663 (FmdE) implicated in microbial methanogenesis reveal a conserved α+β core domain and an auxiliary C-terminal treble-clef zinc finger

    The first structures from the FmdE Pfam family (PF02663) reveal that some members of this family form tightly intertwined dimers consisting of two domains (N-terminal α+β core and C-terminal zinc-finger domains), whereas others contain only the core domain. The presence of the zinc-finger domain suggests that some members of this family may perform functions associated with transcriptional regulation, protein–protein interaction, RNA binding or metal-ion sensing. Examination of the genomic context for members of the FmdE Pfam family (PF02663), such as the protein encoded by the fmdE gene from the methanogenic archaeon Methanobacterium thermoautotrophicum, indicates that 13 of them are co-transcribed with genes encoding subunits of molybdenum formylmethanofuran dehydrogenase (EC 1.2.99.5), an enzyme that is involved in microbial methane production. Here, the first crystal structures from PF02663 are described, representing two bacterial and one archaeal species: B8FYU2-DESHY from the anaerobic dehalogenating bacterium Desulfitobacterium hafniense DCB-2, Q2LQ23-SYNAS from the syntrophic bacterium Syntrophus aciditrophicus SB and Q9HJ63-THEAC from the thermoacidophilic archaeon Thermoplasma acidophilum. Two of these proteins, Q9HJ63-THEAC and Q2LQ23-SYNAS, contain two domains: an N-terminal thioredoxin-like α+β core domain (NTD) consisting of a five-stranded, mixed β-sheet flanked by several α-helices and a C-terminal zinc-finger domain (CTD). B8FYU2-DESHY, on the other hand, is composed solely of the NTD. The CTD of Q9HJ63-THEAC and Q2LQ23-SYNAS is best characterized as a treble-clef zinc finger. Two significant structural differences between Q9HJ63-THEAC and Q2LQ23-SYNAS involve their metal binding. First, zinc is bound to the putative active site on the NTD of Q9HJ63-THEAC, but is absent from the NTD of Q2LQ23-SYNAS. Second, whereas the structure of the CTD of Q2LQ23-SYNAS shows four Cys side chains within coordination distance of the Zn atom, the structure

  18. Rolling friction robot fingers

    Vranish, John M.

    1992-06-01

    A low friction, object guidance, and gripping finger device for a robotic end effector on a robotic arm is disclosed, having a pair of robotic fingers each having a finger shaft slideably located on a gripper housing attached to the end effector. Each of the robotic fingers has a roller housing attached to the finger shaft. The roller housing has a ball bearing mounted centering roller located at the center, and a pair of ball bearing mounted clamping rollers located on either side of the centering roller. The object has a recess to engage the centering roller and a number of seating ramps for engaging the clamping rollers. The centering roller acts to position and hold the object symmetrically about the centering roller with respect to the X axis and the clamping rollers act to position and hold the object with respect to the Y and Z axis.

  19. The creation of the artificial RING finger from the cross-brace zinc finger by α-helical region substitution

    The creation of the artificial RING finger as ubiquitin-ligating enzyme (E3) has been demonstrated. In this study, by the α-helical region substitution between the EL5 RING finger and the Williams-Beuren syndrome transcription factor (WSTF) PHD finger, the artificial E3 (WSTF PHDRING finger) was newly created. The experiments of the chemical modification of residues Cys and the circular dichroism spectra revealed that the WSTF PHDRING finger binds two zinc atoms and adopts the zinc-dependent ordered-structure. In the substrate-independent ubiquitination assay, the WSTF PHDRING finger functions as E3 and was poly- or mono-ubiquitinated. The present strategy is very simple and convenient, and consequently it might be widely applicable to the creation of various artificial E3 RING fingers with the specific ubiquitin-conjugating enzyme (E2)-binding capability.

  20. Multiple Fingers - One Gestalt.

    Lezkan, Alexandra; Manuel, Steven G; Colgate, J Edward; Klatzky, Roberta L; Peshkin, Michael A; Drewing, Knut

    2016-01-01

    The Gestalt theory of perception offered principles by which distributed visual sensations are combined into a structured experience ("Gestalt"). We demonstrate conditions whereby haptic sensations at two fingertips are integrated in the perception of a single object. When virtual bumps were presented simultaneously to the right hand's thumb and index finger during lateral arm movements, participants reported perceiving a single bump. A discrimination task measured the bump's perceived location and perceptual reliability (assessed by differential thresholds) for four finger configurations, which varied in their adherence to the Gestalt principles of proximity (small versus large finger separation) and synchrony (virtual spring to link movements of the two fingers versus no spring). According to models of integration, reliability should increase with the degree to which multi-finger cues integrate into a unified percept. Differential thresholds were smaller in the virtual-spring condition (synchrony) than when fingers were unlinked. Additionally, in the condition with reduced synchrony, greater proximity led to lower differential thresholds. Thus, with greater adherence to Gestalt principles, thresholds approached values predicted for optimal integration. We conclude that the Gestalt principles of synchrony and proximity apply to haptic perception of surface properties and that these principles can interact to promote multi-finger integration. PMID:26863671

  1. Prediction of DNA-binding specificity in zinc finger proteins

    Sumedha Roy; Shayoni Dutta; Kanika Khanna; Shruti Singla; Durai Sundar

    2012-07-01

    Zinc finger proteins interact via their individual fingers to three base pair subsites on the target DNA. The four key residue positions −1, 2, 3 and 6 on the alpha-helix of the zinc fingers have hydrogen bond interactions with the DNA. Mutating these key residues enables generation of a plethora of combinatorial possibilities that can bind to any DNA stretch of interest. Exploiting the binding specificity and affinity of the interaction between the zinc fingers and the respective DNA can help to generate engineered zinc fingers for therapeutic purposes involving genome targeting. Exploring the structure–function relationships of the existing zinc finger–DNA complexes can aid in predicting the probable zinc fingers that could bind to any target DNA. Computational tools ease the prediction of such engineered zinc fingers by effectively utilizing information from the available experimental data. A study of literature reveals many approaches for predicting DNA-binding specificity in zinc finger proteins. However, an alternative approach that looks into the physico-chemical properties of these complexes would do away with the difficulties of designing unbiased zinc fingers with the desired affinity and specificity. We present a physico-chemical approach that exploits the relative strengths of hydrogen bonding between the target DNA and all combinatorially possible zinc fingers to select the most optimum zinc finger protein candidate.

  2. Fingers that change color

    ... cause fingers or toes to change color: Buerger disease Chilblains. Painful inflammation of small blood vessels. Cryoglobulinemia Frostbite Necrotizing vasculitis Peripheral artery disease Raynaud phenomenon. Sudden change in the ...

  3. Replantation (Finger, Hand, or Arm)

    ... Symptom Picker Hand and Arm Conditions Carpal Tunnel Ganglion Cysts Trigger Finger Arthritis Base of the Thumb See ... Symptom Picker Hand and Arm Conditions Carpal Tunnel Ganglion Cysts Trigger Finger Arthritis Base of the Thumb See ...

  4. Spiral viscous fingering.

    Nagatsu, Yuichiro; Hayashi, Atsushi; Kato, Yoshihito; Tada, Yutaka

    2006-11-01

    When a less-viscous fluid displaces a more-viscous fluid in a radial Hele-Shaw cell, viscous fingering pattern is believed to develop in a radial direction. We performed experiments on viscous fingering in a radial Hele-Shaw cell when a polymer solution, a sodium polyacrylate (SPA) solution is used as the more-viscous fluid and the trivalent iron (Fe^3+) solution is as the less-viscous fluid. The experiment was done by varying the concentration of Fe^3+, cFe3+. We have found that viscous fingering pattern develops spirally when cFe3+ is larger than a threshold value, while the pattern develops in a radial direction for small cFe3+. We confirmed from different experiments that an instantaneous chemical reaction takes place between SPA solution and Fe^3+ solution. The chemical reaction produces precipitation and significantly reduces the viscosity of the SPA solution. The quantity of the precipitation is increased with cFe3+. We will make a discussion on the relationship between the formation of spiral viscous fingering and the chemical reaction taking place between the two fluids.

  5. X-Ray Exam: Finger

    ... Tropical Delight: Melon Smoothie Pregnant? Your Baby's Growth X-Ray Exam: Finger KidsHealth > For Parents > X-Ray Exam: Finger Print A A A Text Size ... español Radiografía: dedo What It Is A finger X-ray is a safe and painless test that uses ...

  6. Safe Finger Tourniquet-Ideas.

    Wei, Lin-Gwei; Chen, Chieh-Feng; Hwang, Chun-Yuan; Chang, Chiung-Wen; Chiu, Wen-Kuan; Li, Chun-Chang; Wang, Hsian-Jenn

    2016-03-01

    Tourniquets are often needed for optimized phalangeal surgeries. However, few surgeons forget to remove them and caused ischemic injuries. We have a modified method to create a safe finger tourniquet for short duration finger surgeries, which can avoid such tragedy. It is done by donning a glove, cutting the tip of the glove over the finger of interest, and rolling the glove finger to the base. From 2010 to 2013, approximately 54 patients underwent digital surgical procedures with our safe finger tourniquet. Because the glove cannot be forgotten to be removed, the tourniquet must be released and removed. This is a simple and efficient way to apply a safe finger tourniquet by using hand rubber glove for a short-term bloodless finger surgery and can achieve an excellent surgical result. PMID:26855166

  7. Handedness and index finger movements performed on a small touchscreen.

    Aoki, Tomoko; Rivlis, Gil; Schieber, Marc H

    2016-02-01

    Many studies of right/left differences in motor performance related to handedness have employed tasks that use arm movements or combined arm and hand movements rather than movements of the fingers per se, the well-known exception being rhythmic finger tapping. We therefore explored four simple tasks performed on a small touchscreen with relatively isolated movements of the index finger. Each task revealed a different right/left performance asymmetry. In a step-tracking Target Task, left-handed subjects showed greater accuracy with the index finger of the dominant left hand than with the nondominant right hand. In a Center-Out Task, right-handed subjects produced trajectories with the nondominant left hand that had greater curvature than those produced with the dominant right hand. In a continuous Circle Tracking Task, slips of the nondominant left index finger showed higher jerk than slips of the dominant right index finger. And in a continuous Complex Tracking Task, the nondominant left index finger showed shorter time lags in tracking the relatively unpredictable target than the dominant right index finger. Our findings are broadly consistent with previous studies indicating left hemisphere specialization for dynamic control and predictable situations vs. right hemisphere specialization for impedance control and unpredictable situations, the specialized contributions of the two hemispheres being combined to different degrees in the right vs. left hands of right-handed vs. left-handed individuals. PMID:26683065

  8. Single active finger IPMC microgripper

    This paper presents a new design for a single active finger ionic polymer metal composite (IPMC) microgripper. This design has one stationary finger and one actuating finger. The gripper is tested in comparison with a two fingered gripper (2FG) on its ability to perform pick and place operations. The grippers each use IPMC strips in three widths: 1.25 mm, 2.5 mm and 5.0 mm. The single fingered gripper shows success rates of 86.2%, 89.2%, and 75% respectively versus 78.5%, 93.9% and 75% for a 2FG. The single fingered gripper performance is nearly equivalent to that of a 2FG. Even though a single finger produces half the force, its ability to carry objects is as good as or better than a 2FG. In addition, the stationary finger is considerably stiffer than an active IPMC finger, which helps in positional accuracy. Using half the IPMC, the single fingered gripper is the economical choice. (paper)

  9. Viscous fingering patterns in ferrofluids

    Widom, Michael; Miranda, Jose A.

    1998-01-01

    Viscous fingering occurs in the flow of two immiscible, viscous fluids between the plates of a Hele-Shaw cell. Due to pressure gradients or gravity, the initially planar interface separating the two fluids undergoes a Saffman-Taylor instability and develops finger-like structures. When one of the fluids is a ferrofluid and a perpendicular magnetic field is applied, the labyrinthine instability supplements the usual viscous fingering instability, resulting in visually striking, complex pattern...

  10. Finger Forces in Clarinet Playing

    Hofmann, Alex; Goebl, Werner

    2016-01-01

    Clarinettists close and open multiple tone holes to alter the pitch of the tones. Their fingering technique must be fast, precise, and coordinated with the tongue articulation. In this empirical study, finger force profiles and tongue techniques of clarinet students (N = 17) and professional clarinettists (N = 6) were investigated under controlled performance conditions. First, in an expressive-performance task, eight selected excerpts from the first Weber Concerto were performed. These excerpts were chosen to fit in a 2 × 2 × 2 design (register: low–high; tempo: slow–fast, dynamics: soft–loud). There was an additional condition controlled by the experimenter, which determined the expression levels (low–high) of the performers. Second, a technical-exercise task, an isochronous 23-tone melody was designed that required different effectors to produce the sequence (finger-only, tongue-only, combined tongue-finger actions). The melody was performed in three tempo conditions (slow, medium, fast) in a synchronization-continuation paradigm. Participants played on a sensor-equipped Viennese clarinet, which tracked finger forces and reed oscillations simultaneously. From the data, average finger force (Fmean) and peak force (Fmax) were calculated. The overall finger forces were low (Fmean = 1.17 N, Fmax = 3.05 N) compared to those on other musical instruments (e.g., guitar). Participants applied the largest finger forces during the high expression level performance conditions (Fmean = 1.21 N). For the technical exercise task, timing and articulation information were extracted from the reed signal. Here, the timing precision of the fingers deteriorated the timing precision of the tongue for combined tongue-finger actions, especially for faster tempi. Although individual finger force profiles were overlapping, the group of professional players applied less finger force overall (Fmean = 0.54 N). Such sensor instruments provide useful insights into player

  11. Robotic Finger Assembly

    Ihrke, Chris A. (Inventor); Bridgwater, Lyndon (Inventor); Diftler, Myron A. (Inventor); Linn, Douglas Martin (Inventor); Platt, Robert J., Jr. (Inventor); Hargrave, Brian (Inventor); Askew, Scott R. (Inventor); Valvo, Michael C. (Inventor)

    2014-01-01

    A robotic hand includes a finger with first, second, and third phalanges. A first joint rotatably connects the first phalange to a base structure. A second joint rotatably connects the first phalange to the second phalange. A third joint rotatably connects the third phalange to the second phalange. The second joint and the third joint are kinematically linked such that the position of the third phalange with respect to the second phalange is determined by the position of the second phalange with respect to the first phalange.

  12. Ultrafast resonance energy transfer from a site-specifically attached fluorescent chromophore reveals the folding of the N-terminal domain of CP29

    van Oort, Bart; Murali, Sukumaran; Wientjes, Emilie; Koehorst, Rob B. M.; Spruijt, Ruud B.; van Hoek, Arie; Croce, Roberta; van Amerongen, Herbert

    2009-02-01

    The photosynthetic minor antenna complex CP29 of higher plants was singly mutated, overexpressed in Escherichia coli, selectively labeled with the fluorescent dye TAMRA at three positions in the N-terminal domain, and reconstituted with its natural pigments. Picosecond fluorescence experiments revealed rapid excitation energy transfer (˜20 ps) from TAMRA covalently attached to a cysteine at either position 4 or 97 (near the beginning and end of the N-terminal domain) to the chlorophylls in the hydrophobic part of the protein. This indicates that the N-terminus is folded back on the hydrophobic core. In 20% of the complexes, efficient transfer was lacking, indicating that the N-terminus can adopt different conformations. Time-resolved polarized fluorescence measurements demonstrate that the non-transferring conformations only allow restricted rotational motion of the dye molecule. When TAMRA was attached to a cysteine at position 40, the overall transfer efficiency was far lower, reflecting a larger distance to the hydrophobic region.

  13. Treatment of degloving injury of three fingers with an anterolateral thigh flap

    YU Guang; LEI Hong-yu; GUO Shuang; YU Hao; HUANG Jian-hua

    2011-01-01

    The degloving injuries of the digits and palm remain a persistent challenge. We used an anterolateral thigh flap to treat an 18-year-old, right-handed male worker with degloving injuries of the index, middle and ring fingers. The flap was designated to wrap the entire circumference of three fingers sustaining degloving injury and to form mitten-hand. The total lengths of the distal phalanxes of three fingers were retained almost complete. The donor defect was covered with split-thickness skin graft. Three months after the first operation, roentgenograms revealed terminal phalanxex resorption in three injured fingers, and the surgical syndactyly between the middle and ring finger was separated at the same time. One month later, the syndactyly between the index and middle fingers was also separated. Good coverage of the soft tissue defects with good function and appearance was achieved. Therefore,we considered that the length of the degloved finger could be preserved using free flap.

  14. Covering the Dorsal Finger Defect with Reverse Cross Finger Flap

    Kaan Gurbuz

    2014-12-01

    Full Text Available Reconstruction of finger extensor zone defects with or without tendon gaps still remains a challenge for surgeons. Although surgical treatments may differ, and range from the use of local, regional, to free flaps, the outcomes for all cases are not satisfactory. In this case report, we present a case of a 3rd finger extensor side crush injury including a defect of Dd (Digit Dorsal 1, Dd2 and Dd3 defects of extensor zones with tendon gap. Tendon gap was reconstructed using m. palmaris longus tendon graft and the defect was covered with reversed cross-finger flap (random pattern with good cosmetic and excellent functional results.

  15. Transfer of tactile perceptual learning to untrained neighboring fingers reflects natural use relationships.

    Dempsey-Jones, Harriet; Harrar, Vanessa; Oliver, Jonathan; Johansen-Berg, Heidi; Spence, Charles; Makin, Tamar R

    2016-03-01

    Tactile learning transfers from trained to untrained fingers in a pattern that reflects overlap between the representations of fingers in the somatosensory system (e.g., neurons with multifinger receptive fields). While physical proximity on the body is known to determine the topography of somatosensory representations, tactile coactivation is also an established organizing principle of somatosensory topography. In this study we investigated whether tactile coactivation, induced by habitual inter-finger cooperative use (use pattern), shapes inter-finger overlap. To this end, we used psychophysics to compare the transfer of tactile learning from the middle finger to its adjacent fingers. This allowed us to compare transfer to two fingers that are both physically and cortically adjacent to the middle finger but have differing use patterns. Specifically, the middle finger is used more frequently with the ring than with the index finger. We predicted this should lead to greater representational overlap between the former than the latter pair. Furthermore, this difference in overlap should be reflected in differential learning transfer from the middle to index vs. ring fingers. Subsequently, we predicted temporary learning-related changes in the middle finger's representation (e.g., cortical magnification) would cause transient interference in perceptual thresholds of the ring, but not the index, finger. Supporting this, longitudinal analysis revealed a divergence where learning transfer was fast to the index finger but relatively delayed to the ring finger. Our results support the theory that tactile coactivation patterns between digits affect their topographic relationships. Our findings emphasize how action shapes perception and somatosensory organization. PMID:26631145

  16. Steadily translating parabolic dissolution fingers

    Kondratiuk, Paweł

    2015-01-01

    Dissolution fingers (or wormholes) are formed during the dissolution of a porous rock as a result of nonlinear feedbacks between the flow, transport and chemical reactions at pore surfaces. We analyze the shapes and growth velocities of such fingers within the thin-front approximation, in which the reaction is assumed to take place instantaneously with the reactants fully consumed at the dissolution front. We concentrate on the case when the main flow is driven by the constant pressure gradient far from the finger, and the permeability contrast between the inside and the outside of the finger is finite. Using Ivantsov ansatz and conformal transformations we find the family of steadily translating fingers characterized by a parabolic shape. We derive the reactant concentration field and the pressure field inside and outside of the fingers and show that the flow within them is uniform. The advancement velocity of the finger is shown to be inversely proportional to its radius of curvature in the small P\\'{e}clet...

  17. Finger Forces in Clarinet Playing.

    Hofmann, Alex; Goebl, Werner

    2016-01-01

    Clarinettists close and open multiple tone holes to alter the pitch of the tones. Their fingering technique must be fast, precise, and coordinated with the tongue articulation. In this empirical study, finger force profiles and tongue techniques of clarinet students (N = 17) and professional clarinettists (N = 6) were investigated under controlled performance conditions. First, in an expressive-performance task, eight selected excerpts from the first Weber Concerto were performed. These excerpts were chosen to fit in a 2 × 2 × 2 design (register: low-high; tempo: slow-fast, dynamics: soft-loud). There was an additional condition controlled by the experimenter, which determined the expression levels (low-high) of the performers. Second, a technical-exercise task, an isochronous 23-tone melody was designed that required different effectors to produce the sequence (finger-only, tongue-only, combined tongue-finger actions). The melody was performed in three tempo conditions (slow, medium, fast) in a synchronization-continuation paradigm. Participants played on a sensor-equipped Viennese clarinet, which tracked finger forces and reed oscillations simultaneously. From the data, average finger force (F mean ) and peak force (F max ) were calculated. The overall finger forces were low (F mean = 1.17 N, F max = 3.05 N) compared to those on other musical instruments (e.g., guitar). Participants applied the largest finger forces during the high expression level performance conditions (F mean = 1.21 N). For the technical exercise task, timing and articulation information were extracted from the reed signal. Here, the timing precision of the fingers deteriorated the timing precision of the tongue for combined tongue-finger actions, especially for faster tempi. Although individual finger force profiles were overlapping, the group of professional players applied less finger force overall (F mean = 0.54 N). Such sensor instruments provide useful insights into player

  18. Fingering Instabilities in Dewetting Nanofluids

    Pauliac-Vaujour, E.; Stannard, A.; Martin, C. P.; Blunt, M. O.; Notingher, I.; Moriarty, P. J.; Vancea, I.; Thiele, U.

    2008-05-01

    The growth of fingering patterns in dewetting nanofluids (colloidal solutions of thiol-passivated gold nanoparticles) has been followed in real time using contrast-enhanced video microscopy. The fingering instability on which we focus here arises from evaporatively driven nucleation and growth in a nanoscopically thin precursor solvent film behind the macroscopic contact line. We find that well-developed isotropic fingering structures only form for a narrow range of experimental parameters. Numerical simulations, based on a modification of the Monte Carlo approach introduced by Rabani et al. [Nature (London)NATUAS0028-0836 426, 271 (2003)10.1038/nature02087], reproduce the patterns we observe experimentally.

  19. Interaction of finger enslaving and error compensation in multiple finger force production

    Martin, Joel R.; Mark L. Latash; Zatsiorsky, Vladimir M.

    2008-01-01

    Previous studies have documented two patterns of finger interaction during multi-finger pressing tasks, enslaving and error compensation, which do not agree with each other. Enslaving is characterized by positive correlation between instructed (master) and non-instructed (slave) finger(s) while error compensation can be described as a pattern of negative correlation between master and slave fingers. We hypothesize that pattern of finger interaction, enslaving or compensation, depends on the i...

  20. Mesofluidic controlled robotic or prosthetic finger

    Lind, Randall F; Jansen, John F; Love, Lonnie J

    2013-11-19

    A mesofluidic powered robotic and/or prosthetic finger joint includes a first finger section having at least one mesofluidic actuator in fluid communication with a first actuator, a second mesofluidic actuator in fluid communication with a second actuator and a second prosthetic finger section pivotally connected to the first finger section by a joint pivot, wherein the first actuator pivotally cooperates with the second finger to provide a first mechanical advantage relative to the joint point and wherein the second actuator pivotally cooperates with the second finger section to provide a second mechanical advantage relative to the joint point.

  1. The SABS finger ring service

    All radiation workers are required by law to wear personal dosimeters to measure the radiation dose they receive in the course of their work. However, there was a need to measure the radiation dose received by the fingers and hands, because they are much closer to the source of radiation than the rest of the body. In April 1982 a finger ring service was instituted on a routine basis. A thermoluminescent dosimeter (TLD) is used, which is suitable for both X-rays and gamma rays. Materials that are used for thermoluminescent dosimeters includes LiF:Mg, CaF2:Dy and CaSO4:Dy

  2. Cystic Eccrine Spiradenoma of the Finger Mimicking a Ganglion

    Khalid F. Jaber, MBChB

    2014-01-01

    Full Text Available Summary: We report a rare case of cystic eccrine spiradenoma in the finger. A 46-year-old man presented with a cystic mass in his left index finger. Clinical assessment along with the investigation pointed toward a diagnosis of a ganglion. However, excisional biopsy of the mass revealed histopathological findings of cystic eccrine spiradenoma. Very few cases of eccrine spiradenoma have been reported in the hand and none of them were cystic in consistency. We believe that this case will draw the surgeon’s attention to the possibility of unusual differential diagnoses in the evaluation and treatment of cystic lumps in the hand.

  3. Fjords in viscous fingering: selection of width and opening scale

    Mineev-weinstein, Mark [Los Alamos National Laboratory; Ristroph, Leif [UT-AUSTIN; Thrasher, Matthew [UT-AUSTIN; Swinney, Harry [UT-AUSTIN

    2008-01-01

    Our experiments on viscous fingering of air into oil contained between closely spaced plates reveal two selection rules for the fjords of oil that separate fingers of air. (Fjords are the building blocks of solutions of the zero-surface-tension Laplacian growth equation.) Experiments in rectangular and circular geometries yield fjords with base widths {lambda}{sub c}/2, where {lambda}{sub c} is the most unstable wavelength from a linear stability analysis. Further, fjords open at an angle of 8.0{sup o}{+-}1.0{sup o}. These selection rules hold for a wide range of pumping rates and fjord lengths, widths, and directions.

  4. Joint Replacement (Finger and Wrist Joints)

    ... Symptom Picker Hand and Arm Conditions Carpal Tunnel Ganglion Cysts Trigger Finger Arthritis Base of the Thumb See ... Symptom Picker Hand and Arm Conditions Carpal Tunnel Ganglion Cysts Trigger Finger Arthritis Base of the Thumb See ...

  5. 'Frozen finger' in anal fissures.

    Chintamani; Tandon, Megha; Khandelwal, Rohan

    2009-10-01

    Acute anal fissures are usually managed by various invasive and non-invasive modalities ranging from simple lifestyle changes to chemical and surgical sphincterotomies. Frozen finger, prepared using a water-filled ordinary rubber glove, was successfully used in one hundred patients, thus providing a cost-effective and simple solution to the problem. PMID:19671780

  6. Radiation safety education reduces the incidence of adult fingers on neonatal chest radiographs

    A previous audit revealed a high frequency of adult fingers visualised on neonatal intensive care unit (NICU) chest radiographs—representing an example of inappropriate occupational radiation exposure. Radiation safety education was provided to staff and we hypothesised that the education would reduce the frequency of adult fingers visualised on NICU chest radiographs. Two cross-sectional samples taken before and after the administration of the education were compared. We examined fingers visualised directly in the beam, fingers in the direct beam but eliminated by technologists editing the image, and fingers under the cones of the portable x-ray machine. There was a 46.2% reduction in fingers directly in the beam, 50.0% reduction in fingers directly in the beam but cropped out, and 68.4% reduction in fingers in the coned area. There was a 57.1% overall reduction in adult fingers visualised, which was statistically significant (Z value − 7.48, P < 0.0001). This study supports radiation safety education in minimising inappropriate occupational radiation exposure. (paper)

  7. 27 CFR 9.34 - Finger Lakes.

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Finger Lakes. 9.34 Section... Lakes. (a) Name. The name of the viticultural area described in this section is “Finger Lakes.” (b) Approved maps. The appropriate maps for determining the boundaries of the Finger Lakes viticultural...

  8. Multi-finger interaction during involuntary and voluntary single finger force changes

    J R Martin; Zatsiorsky, V.M.; Latash, M.L.

    2010-01-01

    Two types of finger interaction are characterized by positive co-variation (enslaving) or negative co-variation (error compensation) of finger forces. Enslaving reflects mechanical and neural connections among fingers, while error compensation results from synergic control of fingers to stabilize their net output. Involuntary and voluntary force changes by a finger were used to explore these patterns. We hypothesized that synergic mechanisms will dominate during involuntary force changes, whi...

  9. Gravity-driven fingering in unsaturated fractures

    Gravity-driven wetting-front instability is known to occur in both porous media and Hele-Shaw cells. A systematic investigative procedure for studying gravity-driven fingering in unsaturated, rough-walled fractures is described. As a first step toward understanding this system, experiments were performed in an analogue fracture consisting of two roughened glass plates held in close contact. Results from preliminary experiments in both initially dry and wet analogue fractures are presented, including measurements taken from individual fingers within a fully unstable flow field. For initially dry fractures, increasing the volume of fluid contained in the front leads to increases in both finger width and velocity. Finger velocity also was observed to increase with gravitational gradient. Once a finger structure develops in an initially dry fracture, the structure persists in subsequent infiltration events. In uniformly wet fractures, fingers are found to be more numerous and thinner and to have higher velocity than fingers formed in initially dry fractures

  10. Does finger sense predict addition performance?

    Newman, Sharlene D

    2016-05-01

    The impact of fingers on numerical and mathematical cognition has received a great deal of attention recently. However, the precise role that fingers play in numerical cognition is unknown. The current study explores the relationship between finger sense, arithmetic and general cognitive ability. Seventy-six children between the ages of 5 and 12 participated in the study. The results of stepwise multiple regression analyses demonstrated that while general cognitive ability including language processing was a predictor of addition performance, finger sense was not. The impact of age on the relationship between finger sense, and addition was further examined. The participants were separated into two groups based on age. The results showed that finger gnosia score impacted addition performance in the older group but not the younger group. These results appear to support the hypothesis that fingers provide a scaffold for calculation and that if that scaffold is not properly built, it has continued differential consequences to mathematical cognition. PMID:26993292

  11. Finger Indexed Sets: New Approaches

    Sioutas, Spyros

    2008-01-01

    In the particular case we have insertions/deletions at the tail of a given set S of $n$ one-dimensional elements, we present a simpler and more concrete algorithm than that presented in [Anderson, 2007] achieving the same (but also amortized) upper bound of $O(\\sqrt{logd/loglogd})$ for finger searching queries, where $d$ is the number of sorted keys between the finger element and the target element we are looking for. Furthermore, in general case we have insertions/deletions anywhere we present a new randomized algorithm achieving the same expected time bounds. Even the new solutions achieve the optimal bounds in amortized or expected case, the advantage of simplicity is of great importance due to practical merits we gain.

  12. FINGER-VEIN RECOGNITION SYSTEMS

    A.Haritha Deepthi

    2015-10-01

    Full Text Available As the Person‟s/Organization‟s Private information‟s are becoming very easy to access, the demand for a Simple, Convenient, Efficient, and a highly Securable Authentication System has been increased. In considering these requirements for data Protection, Biometrics, which uses human physiological or behavioral system for personal Identification has been found as a solution for these difficulties. However most of the biometric systems have high complexity in both time and space. So we are going to use a Real time Finger-Vein recognition System for authentication purposes. In this paper we had implemented the Finger Vein Recognition concept using MATLAB R2013a. The features used are Lacunarity Distance, Blanket Dimension distance. This has more accuracy when compared to conventional methods.

  13. Finger clubbing in cystic fibrosis.

    Pitts-Tucker, T J; Miller, M G; Littlewood, J M

    1986-01-01

    Finger clubbing was measured in 73 of 105 patients with cystic fibrosis undergoing full assessment. The sign correlated well with the chest x ray score and indices of pulmonary function and infection but not with weight, height, age, liver function, or degree of fat malabsorption. The presence of clubbing suggests appreciable pulmonary involvement. Most probably its progression indicates a deterioration in pulmonary state. In both instances increased efforts should be made to treat the infect...

  14. Finger tremor in Parkinson's disease.

    Lakie, M; Mutch, W J

    1989-01-01

    Finger tremor was investigated in 20 patients (age range 54-88 yr) diagnosed as suffering from idiopathic Parkinson's disease and six controls of a similar age and no known neurological abnormality. In nine of the patients tremor was not clinically obvious. When the tremor of these patients was recorded immediately after voluntary movement and subjected to instrumental analysis there were consistently observable differences from the controls. Such analysis may have diagnostic potential when t...

  15. Intravascular papillary endothelial hyperplasia: magnetic resonance imaging of finger lesions

    Sung, Jinkyeong; Kim, Jee-Young [The Catholic University of Korea, Department of Radiology, St. Vincent' s Hospital, College of Medicine, Suwon, Gyeonggi-do (Korea, Republic of); Yoo, Changyoung [The Catholic University of Korea, Department of Hospital Pathology, St. Vincent' s Hospital, College of Medicine, Suwon, Gyeonggi-do (Korea, Republic of)

    2016-02-15

    To describe magnetic resonance imaging (MRI) features of intravascular papillary endothelial hyperplasia (IPEH), to identify findings differentiating IPEH of the finger from that of other locations, and to correlate these with pathology. Nineteen patients with 20 I.E. masses of the finger (n = 13) and other locations (n = 7) were evaluated. All patients underwent MRI, and the results were correlated with pathology. Seventeen IPEHs, including all IPEHs of the finger, were located in the subcutis, the three other lesions in the muscle layer. On T1WI, all masses were isointense or slightly hyperintense. IPEHs of the finger (n = 13) revealed focal hyperintense nodules (n = 2) or central hypointensity (n = 2) on T1WI, hypointensity with a hyperintense rim (n = 7), hyperintensity with hypointense nodules (n = 5), or isointensity with a hypointense rim (n = 1) on T2WI, and rim enhancement (n = 5), heterogeneous enhancement with nodular nonenhanced areas (n = 6), peripheral nodular enhancement (n = 1), or no enhancement (n = 1) on gadolinium-enhanced T1WI. IPEHs of other locations (n = 7) demonstrated focal hyperintense nodules (n = 5) on T1WI, hyperintensity with hypointense nodules (n = 5) or heterogeneous signal intensity (n = 2) on T2WI, and rim or rim and septal enhancement (n = 6) or peripheral nodular enhancement (n = 1). Microscopically, IPEHs were composed of thrombi that were hypointense on T2WI and papillary endothelial proliferations that showed T2 hyperintensity and enhancement. MRI of finger IPEH reveals well-demarcated subcutaneous masses with hypointensity or hypointense nodules with peripheral hyperintensity on T2WI, as well as peripheral enhancement. T1 hyperintense nodules, internal heterogeneity on T2WI, and septal enhancement are more common in IPEH of other locations. (orig.)

  16. On the fly finger knuckle print authentication

    Abe, Narishige; Shinzaki, Takashi

    2014-05-01

    Finger knuckle print authentication has been researched not only as a supplemental authentication modality to fingerprint recognition but also as a method for logging into a PC or entering a building. However, in previous works, some specific devices were necessary to capture a finger knuckle print and users had to keep their fingers perfectly still to capture their finger knuckle. In this paper, we propose a new on the fly finger knuckle print authentication system using a general web camera. In our proposed authentication system, users can input their finger knuckle prints without needing their hand to remain motionless during image capture. We also evaluate the authentication accuracy of the proposed system, achieving an 7% EER under best conditions.

  17. Application of autoradiography in finger print analysis

    In order to broaden the possibilities of developing latent finger prints a tracer technique has been developed using sup(110m)Ag and autoradiographic imaging. This method has been tested on glass, paper and certain plastics. On paper it is possible to visualize finger prints even after previous development using Ninhydrin. It is shown that usable finger prints may be obtained also from materials from which they cannot be obtained using classical methods, e.g., polyethylene and simulated leather. (author)

  18. Nodular fasciitis of the finger

    Kijima, Hiroaki; Okada, Kyoji; Ito, Hiroki; Shimada, Yoichi; Itoi, Eiji [Akita University School of Medicine, Department of Orthopedic Surgery, Akita (Japan); Nanjo, Hiroshi [Akita University Hospital, Department of Clinical Pathology, Akita (Japan)

    2005-02-01

    Nodular fasciitis is a benign reactive lesion, often mistaken for a soft tissue sarcoma in clinical practice. Involvement of the finger is very rare and, as a result, in this location the lesion has sometimes been treated by ray amputation because of misdiagnosis. We report on the clinical and histological features of nodular fasciitis in a 30-year-old man who was treated by excisional biopsy. There has been no evidence of local recurrence at the recent follow-up 8 years after surgery. The importance of careful histological examination to avoid radical surgery should be emphasized because marginal excision can provide good results in the treatment of nodular fasciitis. (orig.)

  19. Ultrafast High-Resolution Mass Spectrometric Finger Pore Imaging in Latent Finger Prints

    Christian Elsner; Bernd Abel

    2014-01-01

    Latent finger prints (LFPs) are deposits of sweat components in ridge and groove patterns, left after human fingers contact with a surface. Being important targets in biometry and forensic investigations they contain more information than topological patterns. With laser desorption mass spectrometry imaging (LD-MSI) we record ‘three-dimensional' finger prints with additional chemical information as the third dimension. Here we show the potential of fast finger pore imaging (FPI) in latent fin...

  20. Hydrodynamic fingering instability of driven wetting films: hindrance by diffusion

    Carles, P.; Troian, S. M.; Cazabat, A. M.; Heslot, F.

    1990-01-01

    Recent experimental and theoretical efforts have revealed the existence of a fingering instability at the moving front of thin liquid films forced to spread under gravitational, rotational or surface shear stresses, as for example by using the Marangoni effect. The authors describe how the presence of a precursor film in front of the spreading macroscopic film, whether it is by prewetting the substrate or by surface diffusion or multilayer absorption, can prevent the development of the instab...

  1. Fluid Mixing from Viscous Fingering

    Jha, Birendra; Juanes, Ruben

    2010-01-01

    We study, by means of numerical simulation, the mixing of two fluids of different viscosities in advection-dominated flows in a porous medium. It is well known that when a less viscous fluid displaces a more viscous fluid, the displacement front is unstable and leads to the formation of a pattern known as viscous fingering. We present a high-resolution simulation approach that is stable for arbitrary viscosity ratios, and study mixing under different configurations with viscosity contrasts up to M = 400. We observe, in agreement with lab experiments, that for high-M displacements, the growth of new fingers follows the trace of previous ones. This channeling effect, which is a result of the nonlocal coupling through the pressure field, greatly reduces mixing. A two-equation mixing model using the scalar variance and its dissipation rate is derived from the advection-diffusion equation. It provides a measure of effective diffusivity due to convective and diffusive mixing processes. Our analysis predicts the opt...

  2. Reversed cross finger subcutaneous flap: A rapid way to cover finger defects

    Fejjal Nawfal

    2008-01-01

    Full Text Available Adequate coverage of dorsal finger wounds is often a challenge. The reversed cross finger subcutaneous flap to cover defects on the dorsum of phalanx constitutes an excellent option for coverage of wounds over the middle and distal phalanges of the index, middle, ring, and small fingers. It′s an easy flap and represents our first choice to cover those defects.

  3. Finger Seal: A Novel Approach to Air to Air Sealing

    Arora, Gul; Steinetz, Bruce; Proctor, Margaret

    2006-01-01

    The gas turbine industry used a variety of sealing mechanisms to contain and direct secondary flows into and around components for cooling, and to limit leakage into and from bearing and disk cavities. The function of these seals is very important to the component efficiencies and attendant engine performance. Most of these seals are labyrinth seals, which are high-leakage seals that are costly to manufacture. In recent years, brush seals have been introduced which have demonstrated significantly reduced leakage, although they are still expensive and have exhibited wear and hysteresis difficulties. A new innovative concept called finger seal, patented by AlliedSignal, has demonstrated leakage similar to brush seals and is cheaper. The finger seal is comprised of a stack of precision photo-etched sheet metal elements, which allows intricate features to be made at very low cost and with the potential to resist wear and provide the compliance necessary to accomodate rotor excursions. Initial testing in the high-speed/high-temperature seal test facility, at the NASA Lewis Research Center, has corroborated the finger seal performance. The testing also revealed hysteresis problems with the current design. A NASA funded research project is in progress to correct the functional deficiencies of the finger seal and to refine its features to provide sufficient seal life for commercial transport engines and other long-life applications. This research will benefit the aeronautical gas turbine industry as a whole in terms of fuel consumption, operational characteristics, and cost. The first phase of this research to reduce finger seal hysteresis has been in progress for the last one year. This paper presents the results of this research to date. In future the research program will address seal performance, manufacturing, cost and life issues. The research program is expected to be completed by December 1998.

  4. Surgical Treatment of Trigger Finger: Open Release

    Firat Ozan

    2016-01-01

    Full Text Available In this study, open A1 pulley release results were evaluated in patients with a trigger finger diagnosis. 45 patients (29 females, 16 males, mean age 50.7 ± 11.9; range (24-79, 45 trigger fingers were released via open surgical technique. On the 25 of 45 cases were involved in the right hand and 16 of them were at the thumb, 2 at index, 6 at the middle and 1 at ring finger. Similarly, at the left hand, 15 of 20 cases were at the thumb, 1 at the index finger, 2 at middle finger and 2 at ring finger. Average follow-up time was 10.2 ± 2.7 (range, 6-15 months. Comorbidities in patients were; diabetes mellitus at 6 cases (13.3%, hypertension at 11 cases (24.4%, hyperthyroidism at 2 cases (4.4%, dyslipidemia at 2 cases (4.4% and lastly 2 cases had carpal tunnel syndrome operation. The mean time between the onset of symptoms to surgery was 6.9 ± 4.8 (range, 2-24 months. Patient satisfaction was very good in 34 cases (75.4% and good in 11 (24.6% patients. The distance between the pulpa of the operated finger and the palm was normal in every case postoperatively. We have not encountered any postoperative complications. We can recommend that; A1 pulley release via open incision is an effective and reliable method in trigger finger surgery.

  5. Axon reflexes in human cold exposed fingers

    Daanen, H.A.M.; Ducharme, M.B.

    2000-01-01

    Exposure of fingers to severe cold induces cold induced vasodilation (CIVD). The mechanism of CIVD is still debated. The original theory states that an axon reflex causes CIVD. To test this hypothesis, axon reflexes were evoked by electrical stimulation of the middle fingers of hands immersed in wat

  6. Finger gnosis predicts a unique but small part of variance in initial arithmetic performance.

    Wasner, Mirjam; Nuerk, Hans-Christoph; Martignon, Laura; Roesch, Stephanie; Moeller, Korbinian

    2016-06-01

    Recent studies indicated that finger gnosis (i.e., the ability to perceive and differentiate one's own fingers) is associated reliably with basic numerical competencies. In this study, we aimed at examining whether finger gnosis is also a unique predictor for initial arithmetic competencies at the beginning of first grade-and thus before formal math instruction starts. Therefore, we controlled for influences of domain-specific numerical precursor competencies, domain-general cognitive ability, and natural variables such as gender and age. Results from 321 German first-graders revealed that finger gnosis indeed predicted a unique and relevant but nevertheless only small part of the variance in initial arithmetic performance (∼1%-2%) as compared with influences of general cognitive ability and numerical precursor competencies. Taken together, these results substantiated the notion of a unique association between finger gnosis and arithmetic and further corroborate the theoretical idea of finger-based representations contributing to numerical cognition. However, the only small part of variance explained by finger gnosis seems to limit its relevance for diagnostic purposes. PMID:26895483

  7. LAXS investigation of finger phantoms

    Osteoporosis is a bone condition that is caused mainly by the degradation of trabecular and cortical bone resulting in the decrease of bone strength and eventually leads to bone fracture. A low angle X-ray scattering (LAXS) system that uses mainly the coherent scattering process for the characterisation of materials was constructed to study such bone conditions. Several finger phantoms were fabricated to simulate bone of varying densities. The LAXS method was able to identify the changes in bone density quite well by comparing energy dispersive X-ray diffraction patterns as well as the angular patterns. Quantitative information can be extracted from such patterns that relate to bone loss. Signature patterns at low exposure times were produced in order to reduce the dose received with reasonable identification power but at slightly higher statistical errors compared with long exposure patterns. Use of other parameters to increase the sensitivity was attempted

  8. Biased wrist and finger coordination in Parkinsonian patients during performance of graphical tasks.

    Dounskaia, Natalia; Van Gemmert, Arend W A; Leis, Berta C; Stelmach, George E

    2009-10-01

    Handwriting impairments in Parkinson's disease (PD) have been associated with micrographia, i.e. diminished letter size. However, dyscoordination of the wrist and fingers may also contribute to handwriting deterioration in PD. To investigate this hypothesis, right-handed PD patients and controls were tested in performance of three types of cyclic wrist and finger movements: drawing of two lines and a circle. The line drawing was performed with either simultaneous flexion and extension of the wrist and fingers (equivalent pattern resulting in a right-tilted line) or with wrist flexion/extension accompanied with finger extension/flexion (nonequivalent pattern resulting in a left-tilted line). Circle drawing required a specific phase difference between wrist and finger motions. Movements were performed with an inkless pen on a digitizer-tablet at two frequency levels. Consistent deformations of the circle into right-tilted ovals and lower variability in equivalent compared with nonequivalent lines revealed preference to produce right-tilted shapes. This preference became more apparent with increased movement speed and it was amplified in PD patients. Analysis revealed that the circle deformation emerged mainly due to reduction in relative phase, while wrist and finger amplitudes remained unchanged. The results suggest that PD causes deficit characterized by strong tendency to produce certain coordination patterns between wrist and finger motions. This deficit may significantly contribute to handwriting impairments in PD by reducing the dexterity in the production of the variety of shapes of the cursive letters. Furthermore, the deficiency revealed in wrist and finger coordination may represent a more general deficit affecting control of various multi-joint movements in PD. PMID:19410590

  9. EEG Resolutions in Detecting and Decoding Finger Movements from Spectral Analysis

    Ran eXiao

    2015-09-01

    Full Text Available Mu/beta rhythms are well-studied brain activities that originate from sensorimotor cortices. These rhythms reveal spectral changes in alpha and beta bands induced by movements of different body parts, e.g. hands and limbs, in electroencephalography (EEG signals. However, less can be revealed in them about movements of different fine body parts that activate adjacent brain regions, such as individual fingers from one hand. Several studies have reported spatial and temporal couplings of rhythmic activities at different frequency bands, suggesting the existence of well-defined spectral structures across multiple frequency bands. In the present study, spectral principal component analysis (PCA was applied on EEG data, obtained from a finger movement task, to identify cross-frequency spectral structures. Features from identified spectral structures were examined in their spatial patterns, cross-condition pattern changes, detection capability of finger movements from resting, and decoding performance of individual finger movements in comparison to classic mu/beta rhythms. These new features reveal some similar, but more different spatial and spectral patterns as compared with classic mu/beta rhythms. Decoding results further indicate that these new features (91% can detect finger movements much better than classic mu/beta rhythms (75.6%. More importantly, these new features reveal discriminative information about movements of different fingers (fine body-part movements, which is not available in classic mu/beta rhythms. The capability in decoding fingers (and hand gestures in the future from EEG will contribute significantly to the development of noninvasive brain computer interface (BCI and neuroprosthesis with intuitive and flexible controls.

  10. A Site Rediscovered

    Mailhot, Sarah Anne

    2013-01-01

    This is a site-driven project located in my hometown of Lewiston, Maine, a point along the Androscoggin River.  Driving over the bridge as a child, I was intrigued by the waterfall, but it always seemed unattainable; the mills and abandoned buildings prevented access.  When my dad said that the last mill burned down at Great Falls in 2009, I was saddened but knew this provided a new opportunity for the community. This project is not about placing a building, but rather intervening and creatin...

  11. Comparative analysis of zinc finger proteins involved in plant disease resistance.

    Gupta, Santosh Kumar; Rai, Amit Kumar; Kanwar, Shamsher Singh; Sharma, Tilak R

    2012-01-01

    A meta-analysis was performed to understand the role of zinc finger domains in proteins of resistance (R) genes cloned from different crops. We analyzed protein sequences of seventy R genes of various crops in which twenty six proteins were found to have zinc finger domains along with nucleotide binding sites - leucine rice repeats (NBS-LRR) domains. We identified thirty four zinc finger domains in the R proteins of nine crops and were grouped into 19 types of zinc fingers. The size of individual zinc finger domain within the R genes varied from 11 to 84 amino acids, whereas the size of proteins containing these domains varied from 263 to 1305 amino acids. The biophysical analysis revealed that molecular weight of Pi54 zinc finger was lowest whereas the highest one was found in rice Pib zinc finger named as Transposes Transcription Factor (TTF). The instability (R(2) =0.95) and the aliphatic (R(2) =0.94) indices profile of zinc finger domains follows the polynomial distribution pattern. The pairwise identity analysis showed that the Lin11, Isl-1 & Mec-3 (LIM) zinc finger domain of rice blast resistance protein pi21 have 12.3% similarity with the nuclear transcription factor, X-box binding-like 1 (NFX) type zinc finger domain of Pi54 protein. For the first time, we reported that Pi54 (Pi-k(h)-Tetep), a rice blast resistance (R) protein have a small zinc finger domain of NFX type located on the C-terminal in between NBS and LRR domains of the R-protein. Compositional analysis depicted by the helical wheel diagram revealed the presence of a hydrophobic region within this domain which might help in exposing the LRR region for a possible R-Avr interaction. This domain is unique among all other cloned plant disease resistance genes and might play an important role in broad-spectrum nature of rice blast resistance gene Pi54. PMID:22916136

  12. Double dislocation of finger interphalangeal joints

    Jahangiri, Saqib Aziz; Mestha, Prabhakar; McNally, Scarlett

    2012-01-01

    A 62-year-old, right-hand-dominant man who had dementia and lived in an Elderly Mentally Infirm (EMI) nursing home was admitted through Accident & Emergency (A&E) department following unwitnessed injury to the left little finger.

  13. Stainless steel quadralatch finger test report

    The design of the quadralatch on the universal samplers was changed in response to flammable gas operating constraints. Additional redesign of the fingers was included to facilitate manufacturability. The new design was tested to assure satisfactory performance. It was shown that the fingers can hold a sampler in place with an upward force of at least 2200 N (500 pounds) and that the mechanical remote latch unit can release the quadralatch under this condition of maximum upward force

  14. Surface tension and dynamics of fingering patterns

    Magdaleno, F. X.; Casademunt, J.

    1997-01-01

    We study the minimal class of exact solutions of the Saffman-Taylor problem with zero surface tension, which contains the physical fixed points of the regularized (non-zero surface tension) problem. New fixed points are found and the basin of attraction of the Saffman-Taylor finger is determined within that class. Specific features of the physics of finger competition are identified and quantitatively defined, which are absent in the zero surface tension case. This has dramatic consequences f...

  15. Finger Search in the Implicit Model

    Brodal, Gerth Stølting; Nielsen, Jesper Asbjørn Sindahl; Truelsen, Jakob

    2012-01-01

    We address the problem of creating a dictionary with the finger search property in the strict implicit model, where no information is stored between operations, except the array of elements. We show that for any implicit dictionary supporting finger searches in q(t) = Ω(logt) time, the time to move...... the finger to another element is Ω(q− 1(logn)), where t is the rank distance between the query element and the finger. We present an optimal implicit static structure matching this lower bound. We furthermore present a near optimal implicit dynamic structure supporting search, change-finger, insert......, and delete in times $\\mathcal{O}(q(t))$, $\\mathcal{O}(q^{-1}(\\log n)\\log n)$, $\\mathcal{O}(\\log n)$, and $\\mathcal{O}(\\log n)$, respectively, for any q(t) = Ω(logt). Finally we show that the search operation must take Ω(logn) time for the special case where the finger is always changed to the element...

  16. Finger multibiometric cryptosystems: fusion strategy and template security

    Peng, Jialiang; Li, Qiong; Abd El-Latif, Ahmed A.; Niu, Xiamu

    2014-03-01

    We address two critical issues in the design of a finger multibiometric system, i.e., fusion strategy and template security. First, three fusion strategies (feature-level, score-level, and decision-level fusions) with the corresponding template protection technique are proposed as the finger multibiometric cryptosystems to protect multiple finger biometric templates of fingerprint, finger vein, finger knuckle print, and finger shape modalities. Second, we theoretically analyze different fusion strategies for finger multibiometric cryptosystems with respect to their impact on security and recognition accuracy. Finally, the performance of finger multibiometric cryptosystems at different fusion levels is investigated on a merged finger multimodal biometric database. The comparative results suggest that the proposed finger multibiometric cryptosystem at feature-level fusion outperforms other approaches in terms of verification performance and template security.

  17. OUTFLOWS FROM EVOLVED STARS: THE RAPIDLY CHANGING FINGERS OF CRL 618

    Our ultimate goal is to probe the nature of the collimator of the outflows in the pre-planetary nebula CRL 618. CRL 618 is uniquely suited for this purpose owing to its multiple, bright, and carefully studied finger-shaped outflows east and west of its nucleus. We compare new Hubble Space Telescope images to images in the same filters observed as much as 11 yr ago to uncover large proper motions and surface brightness changes in its multiple finger-shaped outflows. The expansion age of the ensemble of fingers is close to 100 yr. We find strong brightness variations at the fingertips during the past decade. Deep IR images reveal a multiple ring-like structure of the surrounding medium into which the outflows propagate and interact. Tightly constrained three-dimensional hydrodynamic models link the properties of the fingers to their possible formation histories. We incorporate previously published complementary information to discern whether each of the fingers of CRL 618 are the results of steady, collimated outflows or a brief ejection event that launched a set of bullets about a century ago. Finally, we argue on various physical grounds that fingers of CRL 618 are likely to be the result of a spray of clumps ejected at the nucleus of CRL 618 since any mechanism that form a sustained set of unaligned jets is unprecedented

  18. OUTFLOWS FROM EVOLVED STARS: THE RAPIDLY CHANGING FINGERS OF CRL 618

    Balick, Bruce [Department of Astronomy, University of Washington, Seattle, WA 98195-1580 (United States); Huarte-Espinosa, Martin [Department of Physics and Astronomy, University of Rochester, Rochester, NY 14627 (United States); Frank, Adam; Gomez, Thomas [Astronomy Department, University of Texas, Austin, TX 78731-2330 (United States); Alcolea, Javier [Observatorio Astronomico Nacional (IGN), E-28014 Madrid (Spain); Corradi, Romano L. M. [Instituto de Astrofisica de Canarias, E-38200 La Laguna, Tenerife (Spain); Vinkovic, Dejan, E-mail: balick@uw.edu, E-mail: martinHE@pas.rochester.edu, E-mail: afrank@pas.rochester.edu, E-mail: gomezt@astro.as.utexas.edu, E-mail: j.alcolea@oan.es, E-mail: rcorradi@iac.es, E-mail: vinkovic@pmfst.hr [Physics Department, University of Split, Teslina 12/III, HR-21000 Split (Croatia)

    2013-07-20

    Our ultimate goal is to probe the nature of the collimator of the outflows in the pre-planetary nebula CRL 618. CRL 618 is uniquely suited for this purpose owing to its multiple, bright, and carefully studied finger-shaped outflows east and west of its nucleus. We compare new Hubble Space Telescope images to images in the same filters observed as much as 11 yr ago to uncover large proper motions and surface brightness changes in its multiple finger-shaped outflows. The expansion age of the ensemble of fingers is close to 100 yr. We find strong brightness variations at the fingertips during the past decade. Deep IR images reveal a multiple ring-like structure of the surrounding medium into which the outflows propagate and interact. Tightly constrained three-dimensional hydrodynamic models link the properties of the fingers to their possible formation histories. We incorporate previously published complementary information to discern whether each of the fingers of CRL 618 are the results of steady, collimated outflows or a brief ejection event that launched a set of bullets about a century ago. Finally, we argue on various physical grounds that fingers of CRL 618 are likely to be the result of a spray of clumps ejected at the nucleus of CRL 618 since any mechanism that form a sustained set of unaligned jets is unprecedented.

  19. Ultrafast High-Resolution Mass Spectrometric Finger Pore Imaging in Latent Finger Prints

    Elsner, Christian; Abel, Bernd

    2014-11-01

    Latent finger prints (LFPs) are deposits of sweat components in ridge and groove patterns, left after human fingers contact with a surface. Being important targets in biometry and forensic investigations they contain more information than topological patterns. With laser desorption mass spectrometry imaging (LD-MSI) we record `three-dimensional' finger prints with additional chemical information as the third dimension. Here we show the potential of fast finger pore imaging (FPI) in latent finger prints employing LD-MSI without a classical matrix in a high- spatial resolution mode. Thin films of gold rapidly sputtered on top of the sample are used for desorption. FPI employing an optical image for rapid spatial orientation and guiding of the desorption laser enables the rapid analysis of individual finger pores, and the chemical composition of their excretions. With this approach we rapidly detect metabolites, drugs, and characteristic excretions from the inside of the human organism by a minimally-invasive strategy, and distinguish them from chemicals in contact with fingers without any labeling. The fast finger pore imaging, analysis, and screening approach opens the door for a vast number of novel applications in such different fields as forensics, doping and medication control, therapy, as well as rapid profiling of individuals.

  20. Saffman-Taylor fingers with kinetic undercooling

    Gardiner, Bennett P. J.

    2015-02-23

    © 2015 American Physical Society. The mathematical model of a steadily propagating Saffman-Taylor finger in a Hele-Shaw channel has applications to two-dimensional interacting streamer discharges which are aligned in a periodic array. In the streamer context, the relevant regularization on the interface is not provided by surface tension but instead has been postulated to involve a mechanism equivalent to kinetic undercooling, which acts to penalize high velocities and prevent blow-up of the unregularized solution. Previous asymptotic results for the Hele-Shaw finger problem with kinetic undercooling suggest that for a given value of the kinetic undercooling parameter, there is a discrete set of possible finger shapes, each analytic at the nose and occupying a different fraction of the channel width. In the limit in which the kinetic undercooling parameter vanishes, the fraction for each family approaches 1/2, suggesting that this "selection" of 1/2 by kinetic undercooling is qualitatively similar to the well-known analog with surface tension. We treat the numerical problem of computing these Saffman-Taylor fingers with kinetic undercooling, which turns out to be more subtle than the analog with surface tension, since kinetic undercooling permits finger shapes which are corner-free but not analytic. We provide numerical evidence for the selection mechanism by setting up a problem with both kinetic undercooling and surface tension and numerically taking the limit that the surface tension vanishes.

  1. A reverse flow cross finger pedicle skin flap from hemidorsum of finger.

    Mishra, Satyanarayan; Manisundaram, S

    2010-04-01

    A reverse-flow cross-finger pedicle skin flap raised from the hemidorsum has been used, which is a modification of the distally based dorsal cross-finger flap. The flap is raised from the hemidorsum at a plane above the paratenon, the distal-most location of the base being at the level of the distal interphalangeal joint. Thirty-two flaps were used from as many fingers of as many patients. Of these, 31 (97%) flaps survived fully; there was stiffness of finger in one (3%) patient and the two-point discrimination was 4-8mm (n=14). Follow-up period was 2 months to 3 years, the median being 1 year and 3 months. The advantages of this flap are that there is less disruption of veins and less visible disfigurement of the dorsum of the finger when compared to other pedicled cross-finger skin flaps. The disadvantage of this flap is its restricted width. It is recommended as the cross-finger pedicle skin flap of choice when the defect is not wide. PMID:19386561

  2. Autonomous control of multi-fingered hand

    JIANG Li; LIU Hong

    2006-01-01

    This paper describes a novel autonomous control strategy of multi-fingered hand based on a modular control system of dexterous manipulation. A simple proportional-integral-derivative(PID) position control with friction compensation, which requires few friction parameters, is used to realize accurate and smooth trajectory tracking in pregrasp phase. In grasp and manipulation phases, an event-driven switcher is adopted to determine the switching between unconstrained position control and constrained torque control, and an improved explicit integral force control strategy is implemented to realize simultaneously stable contact transition and accurate force tracking. Experimental results have verified the effectiveness of the proposed autonomous control strategy of multi-fingered hand.

  3. Chromatographic finger print analysis of Naringi crenulata by HPTLC technique

    Subramanian Sampathkumar; Ramakrishnan N

    2011-01-01

    Objective:To establish the fingerprint profile of Naringi crenulata (N. crenulata) (Roxb.) Nicols. using high performance thin layer chromatography (HPTLC) technique. Methods: Preliminary phytochemical screening was done and HPTLC studies were carried out. CAMAG HPTLC system equipped with Linomat V applicator, TLC scanner 3, Reprostar 3 and WIN CATS-4 software was used. Results: The results of preliminary phytochemical studies confirmed the presence of protein, lipid, carbohydrate, reducing sugar, phenol, tannin, flavonoid, saponin, triterpenoid, alkaloid, anthraquinone and quinone. HPTLC finger printing of ethanolic extract of stem revealed 10 spots with Rf values in the range of 0.08 to 0.65;bark showed 8 peaks with Rf values in the range of 0.07 to 0.63 and the ethanol extract of leaf revealed 8 peaks with Rf values in the range of 0.09 to 0.49, respectively. The purity of sample was confirmed by comparing the absorption spectra at start, middle and end position of the band. Conclusions:It can be concluded that HPTLC finger printing of N. crenulata may be useful in differentiating the species from the adulterant and act as a biochemical marker for this medicinally important plant in the pharmaceutical industry and plant systematic studies.

  4. Double-V block fingers with cruciform recess

    Voellmer, George M.

    1993-01-01

    In a robot having a gripper including a pair of fingers and a drive motor for driving the fingers toward and away from one another while the fingers remain parallel to each other, the fingers consist of finger pads, which interface with a handle on an object to be grasped, and a shank, which attaches the fingers to the robot gripper. The double-V finger has two orthogonal V-grooves forming in the center of the finger pads and recessed cruciform. The double-V finger is used with a handle on the object to be grasped which is the negative of the finger pads. The handle face consists of V-shaped pads capped with a rectangular cruciform. As the gripper is brought into place near the handle, the finger pads are lined up facing the handle pads. When the finger pad and the handle pad are in proper alignment, the rectangular ridges on the handle fall inside the rectangular grooves on the finger, and the grip is complete.

  5. ANALYSIS WITH MSC ADAMS OF A 5-FINGER AND 3-PHALANX /FINGER UNDER-ACTUATEDMECHANICAL HAND

    Gheorghe POPESCU

    2013-05-01

    Full Text Available This paper studies the analysis with MSC ADAMS of a 5-fingered and 3-phalanx/finger underactuatedmechanical hand, designed by the author to work on industrial robots. Moreover, in order to increasegrasping safety in the automated handling process, the author has fitted each finger with a locking sequence inthe final phase of grasping. Thus, the mechanism of mechanical hand is considered to be a mechanical systemand is treated like a set of rigid bodies connected by mechanical linkages and elastic elements. To model andsimulate this mechanism with MSC ADAMS programme, the author covered the following stages: constructionof the model, testing-simulation, validation, finishing, parameterization, and optimization

  6. Finger tapping analysis in patients with Parkinson's disease and atypical parkinsonism.

    Djurić-Jovičić, Milica; Petrović, Igor; Ječmenica-Lukić, Milica; Radovanović, Saša; Dragašević-Mišković, Nataša; Belić, Minja; Miler-Jerković, Vera; Popović, Mirjana B; Kostić, Vladimir S

    2016-08-01

    The goal of this study was to investigate repetitive finger tapping patterns in patients with Parkinson's disease (PD), progressive supranuclear palsy-Richardson syndrome (PSP-R), or multiple system atrophy of parkinsonian type (MSA-P). The finger tapping performance was objectively assessed in PD (n=13), PSP-R (n=15), and MSA-P (n=14) patients and matched healthy controls (HC; n=14), using miniature inertial sensors positioned on the thumb and index finger, providing spatio-temporal kinematic parameters. The main finding was the lack or only minimal progressive reduction in amplitude during the finger tapping in PSP-R patients, similar to HC, but significantly different from the sequence effect (progressive decrement) in both PD and MSA-P patients. The mean negative amplitude slope of -0.12°/cycle revealed less progression of amplitude decrement even in comparison to HC (-0.21°/cycle, p=0.032), and particularly from PD (-0.56°/cycle, p=0.001), and MSA-P patients (-1.48°/cycle, p=0.003). No significant differences were found in the average finger separation amplitudes between PD, PSP-R and MSA-P patients (pmsa-pd=0.726, pmsa-psp=0.363, ppsp-pd=0.726). The lack of clinically significant sequence effect during finger tapping differentiated PSP-R from both PD and MSA-P patients, and might be specific for PSP-R. The finger tapping kinematic parameter of amplitude slope may be a neurophysiological marker able to differentiate particular forms of parkinsonism. PMID:27343040

  7. Stress Responsive Zinc-finger Protein Gene of Populus euphratica in Tobacco Enhances Salt Tolerance

    2008-01-01

    The Populus euphratica stress responsive zinc-finger protein gene PSTZ, which encodes a protein including typical Cys2/His2 zinc finger structure, was isolated by reverse transcription-polymerase chain reaction from P. euphratica.Northern hybridization revealed that its expression was induced under drought and salt stress conditions. To examine its function, cDNA of the PSTZ gene, driven by the cauliflower mosaic virus 35S promoter, was cloned into a plant expression vector pBin438 and introduced into tobacco plants. Transgenic tobacco showed an enhanced salt tolerance, suggesting that PSTZ may play a role in plant responsiveness to salt stress.

  8. Finger reconstruction for the radiation-induced brachial plexus paralysis. A case report

    The patient is a 70-year-old woman. She received right mastectomy and irradiation (4000 rad) for breast cancer 17 years ago. She was referred with numbness of right fingers, muscle weakness and hypoaesthesia. X-ray photography revealed atrophy of the claviculus and the humerus and osteolysis. No recurrence or metastasis of the tumor was found on MRI and bone scintigraphy. She was diagnosed of radiation-induced brachial plexus paralysis. The finger reconstruction was performed and the function recovered. (H.O.)

  9. Finger reconstruction for the radiation-induced brachial plexus paralysis. A case report

    Tanaka, Ryuji; Ikuta, Yoshikazu; Ishida, Osamu; Takata, Haruhiko; Kimori, Kenji; Ochi, Mitsuo [Hiroshima Univ. (Japan). School of Medicine

    1996-01-01

    The patient is a 70-year-old woman. She received right mastectomy and irradiation (4000 rad) for breast cancer 17 years ago. She was referred with numbness of right fingers, muscle weakness and hypoaesthesia. X-ray photography revealed atrophy of the claviculus and the humerus and osteolysis. No recurrence or metastasis of the tumor was found on MRI and bone scintigraphy. She was diagnosed of radiation-induced brachial plexus paralysis. The finger reconstruction was performed and the function recovered. (H.O.)

  10. YIELD, QUALITY AND NUTRIENT UPTAKE AS INFLUENCED BY ORGANIC MANURES AND INORGANIC FERTILIZERS IN FINGER MILLET

    B.Vajantha; Subbarao, M.; L Madhvilatha

    2015-01-01

    A field experiment was conducted to study the influence of organic manures and chemical fertilizers on yield, nutrient uptake by finger millet and soil fertility status at harvest during kharif 2013 at Agricultural Research Station, Perumallapalle, ANGRAU. The results revealed that significantly highest grain yield (37.21 q ha-1), protein content (8.82%), N uptake (84.80 kg ha-1), P uptake (12.04 kg ha-1), No. of tillers/plant (2.5), No. of fingers/ear head (13) were recorded in inorganic tre...

  11. Tangible Widgets for a Multiplayer Tablet Game in Comparison to Finger Touch

    Christensen, Mads Bock; Fisker, Martin; Topp, Kasper Steen Fischer;

    2015-01-01

    Tangible widgets are graspable physical objects that can be detected by a capacitive touch screen. These are used as an interaction method in the tablet game "Hover Wars", a 2-player competitive combat game. Hover Wars was designed to work mainly with tangible widgets and the affordances thereof in...... mind. A version using finger touch was also implemented and the controls were changed to work optimally with this interaction method. The two versions were compared to each other in a user study, revealing that players tend to prefer the usage of tangible widgets over finger touch. The study also...

  12. Acceleration Workspace of Cooperating Multi-Finger Robot Systems

    Hyungwon Shim; Jihong Lee

    2008-01-01

    We present a mathematical method for acceleration workspace analysis of cooperating multi-finger robot systems using a model of point-contact with friction. A new unified formulation from dynamic equations of cooperating multi-finger robots is derived considering the force and acceleration relationships between the fingers and the object to be handled. From the dynamic equation, maximum translational and rotational acceleration bounds of an object are calculated under given constraints of contact conditions, configurations of fingers, and bounds on the torques of joint actuators for each finger. Here, the rotational acceleration bounds can be applied as an important manipulability index when the multi-finger robot grasps an object. To verify the proposed method, we used a set of case studies with a simple multi-finger mechanism system. The achievable acceleration boundary in task space can be obtained successfully with the proposed method and the acceleration boundary depends on the configurations of fingers.

  13. Effective Length Design of Humanoid Robot Fingers Using Biomimetic Optimization

    Byoung-Ho Kim

    2015-10-01

    Full Text Available In this study, we propose an effective design method for the phalangeal parameters and the total size of humanoid robot fingers based on a biomimetic optimization. For the optimization, an interphalangeal joint coordination parameter and the length constraints inherent in human fingers are considered from a biomimetic perspective. A reasonable grasp formulation is also taken into account from the viewpoint of power grasping, where the grasp space of a humanoid robot finger is importantly considered to determine the phalangeal length parameters. The usefulness of the devised biomimetic optimization method is shown through the design examples of various humanoid robot fingers. In fact, the optimization-based finger design method enables us to determine effectively the proper phalangeal size of humanoid robot fingers for human-like object handling tasks. In addition, we discuss its contribution to the structural configuration and coordinated motion of a humanoid robot finger, and address its practical availability in terms of effective finger design.

  14. Evaluation of endothelial function using finger plethysmography

    2009-01-01

    Evaluation of endothelial function using finger plethysmography A. K. Faizi, D. W. Kornmo and S. Agewall Department of Medicine, Aker University Hospital and Oslo University, Oslo, Norway Correspondence to Stefan Agewall, Department of Medicine, Aker University Hospital and Oslo University, 0514 Oslo, Norway E-mail: Copyright Journal compilation © 2009 Scandinavian Society of Clinical Physiology and Nuclear Medicine KEYWORDS endothelial functio...

  15. Finger cold-induced vasodilation : a review

    Daanen, H.A.M.

    2003-01-01

    Cold-induced vasodilation (CIVD) in the finger tips generally occurs 5-10 min after the start of local cold exposure of the extremities. This phenomenon is believed to reduce the risk of local cold injuries. However, CIVD is almost absent during hypothermia, when survival of the organism takes prece

  16. Zinc finger structure-function in Ikaros

    Marvin; A; Payne

    2011-01-01

    The zinc finger motif was used as a vehicle for the initial discovery of Ikaros in the context of T-cell differentiation and has been central to all subsequent analyses of Ikaros function.The Ikaros gene is alternately spliced to produce several isoforms that confer diversity of function and consequently have complicated analysis of the function of Ikaros in vivo.Key features of Ikaros in vivo function are associated with six C2H2 zinc fingers;four of which are alternately incorporated in the production of the various Ikaros isoforms.Although no complete structures are available for the Ikaros protein or any of its family members,considerable evidence has accumulated about the structure of zinc fingers and the role that this structure plays in the functions of the Ikaros family of proteins.This review summarizes the structural aspects of Ikaros zinc fingers,individually,and in tandem to provide a structural context for Ikaros function and to provide a structural basis to inform the design of future experiments with Ikaros and its family members.

  17. Finger-jointed beams in bending

    Andreasen, Lotte; Hoffmeyer, Preben

    1997-01-01

    An investigation of the dynamic and static fatique of finger-jointed beams in bending was carried out. Results were obtained for five different frequencies from static loading to a load cycle period of two minutes. A total of seven series were long-term tested and five series were short-term tested...

  18. Clubbed fingers: the claws we lost?

    Brouwers, A.A.M.; Vermeij-Keers, C.; Zoelen, E.J.J. van; Gooren, L.J.G.

    2004-01-01

    Clubbed digits resemble the human embryonic fingers and toes, which took like the digits of a claw. Clubbed digits, thus, may represent the return of the embryonic claw and may even represent the claws man has lost during evolution, if ontogenesis realty recapitulates phylogenesis. We put forward th

  19. Periosteal chondroma of the proximal phalanx of the ring finger

    Full text: Introduction: Periosteal chondroma is an uncommon benign chondroid tumour of bone that was first described by Lichtenstein and Hall in 1952. The more common sites of involvement are the metaphyseal region of a long tubular bone, especially the proximal humerus, femur, and phalanges. Roentgenographically this benign tumor can mimic chondrosarcoma. Awareness of this fact is important in order to avoid over diagnosis and resultant overtreatment of the benign lesion. Objectives and tasks: In this report, we aimed to present clinical, radiological and pathological findings of a case with periosteal chondroma. Material and methods: A 20-year-old man presented with a small painless mass on the radial side of his right ring finger of 3 months duration. Results: Physical examination revealed a slightly protuberant, subcutaneous mass, located in the radial aspect of the proximal phalanx of the right ring finger Radiographs of the ring finger showed a mild cortical irregularity in the dorso-radial aspect of the proximal phalanx. There was soft tissue calcification. There was a lucent lesion that eroded the underlying cortex and caused a reactive sclerosis at the base of the saucershaped defect in the bone. In Magnetic resonance imaging (MRI) lesion was isointense to the muscle tissue in T1WI and high intensity in T2WI. Based on the clinical, radiological and histological findings, a diagnosis of periosteal chondroma was made. Conclusion: Periosteal chondroma is a slow growing, benign, chondroid tumor that arises under or in the periosteum on the surface of cortical bone. In considering the differential diagnosis perhaps the most important tumour to distinguish from periosteal chondroma is periosteal chondrosarcoma. Treatment of these lesions is surgical, with a wide excision performed for chondrosarcoma and a local (marginal or intralesional) excision for chondroma. Differentiation from a malignant lesion is therefore crucial to prevent more extensive unnecessary

  20. Linguistic and perceptual-motor contributions to the kinematic properties of the braille reading finger.

    Hughes, Barry; Van Gemmert, Arend W A; Stelmach, George E

    2011-08-01

    Recordings of the dominant finger during the reading of braille sentences by experienced readers reveal that the velocity of the finger changes frequently during the traverse of a line of text. These changes, not previously reported, involve a multitude of accelerations and decelerations, as well as reversals of direction. We investigated the origin of these velocity intermittencies (as well as movement reversals) by asking readers to twice read out-loud or silently sentences comprising high- or low-frequency words which combined to make grammatical sentences that were either meaningful or nonmeaningful. In a control condition we asked braille readers to smoothly scan lines of braille comprised of meaningless cell combinations. Word frequency and re-reading each contribute to the kinematics of finger movements, but neither sentence meaning nor the mode of reading do so. The velocity intermittencies were so pervasive that they are not easily attributable either to linguistic processing, text familiarity, mode of reading, or to sensory-motor interactions with the textured patterns of braille, but seem integral to all braille finger movements except reversals. While language-related processing can affect the finger movements, the effects are superimposed on a highly intermittent velocity profile whose origin appears to lie in the motor control of slow movements. PMID:20691490

  1. Torque control of underactuated tendon-driven fingers

    M. E. Abdallah; Wampler, C. W.

    2011-01-01

    Given an underactuated tendon-driven finger, the finger posture is underdetermined and can move freely ("flop") in a region of slack tendons. This work shows that such an underactuated finger can be operated in tendon force control (rather than position control) with effective performance. The force control eliminates the indeterminate slack while commanding a parameterized space of desired torques. The torque will either push the finger to the joint limits or wrap around an external object w...

  2. Ten Trigger Fingers in an Adult Man : A Case Report

    Lee, Young-Keun; Kam, Byung-Sup; Lee, Kwang-Won; Kim, Whoan-Jeang; Choy, Won-Sik

    2007-01-01

    Trigger finger is a common disease particularly in the middle aged women. A very rare case in which an adult man had 10 trigger fingers was experienced. He was treated with local steroid injections in both thumbs, but trigger finger disease has been aggravated in every digit of both hands. We performed an early operative treatment. Three months after the operation, the patient could perform his work without discomfort in his hands and showed normal range of motion in all fingers.

  3. Directed evolution of improved zinc finger methyltransferases.

    Brian Chaikind

    Full Text Available The ability to target DNA methylation toward a single, user-designated CpG site in vivo may have wide applicability for basic biological and biomedical research. A tool for targeting methylation toward single sites could be used to study the effects of individual methylation events on transcription, protein recruitment to DNA, and the dynamics of such epigenetic alterations. Although various tools for directing methylation to promoters exist, none offers the ability to localize methylation solely to a single CpG site. In our ongoing research to create such a tool, we have pursued a strategy employing artificially bifurcated DNA methyltransferases; each methyltransferase fragment is fused to zinc finger proteins with affinity for sequences flanking a targeted CpG site for methylation. We sought to improve the targeting of these enzymes by reducing the methyltransferase activity at non-targeted sites while maintaining high levels of activity at a targeted site. Here we demonstrate an in vitro directed evolution selection strategy to improve methyltransferase specificity and use it to optimize an engineered zinc finger methyltransferase derived from M.SssI. The unusual restriction enzyme McrBC is a key component of this strategy and is used to select against methyltransferases that methylate multiple sites on a plasmid. This strategy allowed us to quickly identify mutants with high levels of methylation at the target site (up to ∼80% and nearly unobservable levels of methylation at a off-target sites (<1%, as assessed in E. coli. We also demonstrate that replacing the zinc finger domains with new zinc fingers redirects the methylation to a new target CpG site flanked by the corresponding zinc finger binding sequences.

  4. Error compensation during finger force production after oneand four-finger voluntarily fatiguing exercise

    Kruger, Eric S.; Hoopes, Josh A.; Cordial, Rory J.; Li, Sheng

    2007-01-01

    The effect of muscle fatigue on error compensation strategies during multi-finger ramp force production tasks was investigated. Thirteen young, healthy subjects were instructed to produce a total force with four fingers of the right hand to accurately match a visually displayed template. The template consisted of a 3-s waiting period, a 3-s ramp force production (from 0 to 30% maximal voluntary contraction, MVC), and a 3-s constant force production. A series of twelve ramp trials was performe...

  5. Robot-assisted Guitar Hero for finger rehabilitation after stroke.

    Taheri, Hossein; Rowe, Justin B; Gardner, David; Chan, Vicky; Reinkensmeyer, David J; Wolbrecht, Eric T

    2012-01-01

    This paper describes the design and testing of a robotic device for finger therapy after stroke: FINGER (Finger Individuating Grasp Exercise Robot). FINGER makes use of stacked single degree-of-freedom mechanisms to assist subjects in moving individual fingers in a naturalistic grasping pattern through much of their full range of motion. The device has a high bandwidth of control (-3dB at approximately 8 Hz) and is backdriveable. These characteristics make it capable of assisting in grasping tasks that require precise timing. We therefore used FINGER to assist individuals with a stroke (n= 8) and without impairment (n= 4) in playing a game similar to Guitar Hero©. The subjects attempted to move their fingers to target positions at times specified by notes that were graphically streamed to popular music. We show here that by automatically adjusting the robot gains, it is possible to use FINGER to modulate the subject's success rate at the game, across a range of impairment levels. Modulating success rates did not alter the stroke subject's effort, although the unimpaired subjects exerted more force when they were made less successful. We also present a novel measure of finger individuation that can be assessed as individuals play Guitar Hero with FINGER. The results demonstrate the ability of FINGER to provide controlled levels of assistance during an engaging computer game, and to quantify finger individuation after stroke. PMID:23366783

  6. Unveiling the Biometric Potential of Finger-Based ECG Signals

    André Lourenço

    2011-01-01

    Full Text Available The ECG signal has been shown to contain relevant information for human identification. Even though results validate the potential of these signals, data acquisition methods and apparatus explored so far compromise user acceptability, requiring the acquisition of ECG at the chest. In this paper, we propose a finger-based ECG biometric system, that uses signals collected at the fingers, through a minimally intrusive 1-lead ECG setup recurring to Ag/AgCl electrodes without gel as interface with the skin. The collected signal is significantly more noisy than the ECG acquired at the chest, motivating the application of feature extraction and signal processing techniques to the problem. Time domain ECG signal processing is performed, which comprises the usual steps of filtering, peak detection, heartbeat waveform segmentation, and amplitude normalization, plus an additional step of time normalization. Through a simple minimum distance criterion between the test patterns and the enrollment database, results have revealed this to be a promising technique for biometric applications.

  7. Finger and Palmar Ridge Pattern in NIDDM Patients and Controls

    Jyoti Ratan Ghosh, Ph.D.

    2016-02-01

    Full Text Available Dermatoglyphics is a heritable, durable, and age-independent trait in man and widely used as a model trait for population genetics and medical research. Present study is an attempt to understand the association of finger and hypothenar pattern types with non-insulin dependent diabetes mellitus (NIDDM. To achieve the purpose bilateral palm prints of 30 clinically diagnosed adult female NIDDM patients and 60 healthy adult females without having the history of diabetes as non-diabetic were incorporated from the Bengalee Hindu caste population of West Bengal, India. The result demonstrated higher frequency of ulnar loop, radial loop, composite and plain arch in NIDDM patients than non-diabetic individuals. The result also revealed higher occurrence of hypothenar pattern in NIDDM patients than that of non-diabetic individuals. There were significant (p<0.05 differences in finger ridge and hypothenar patterns between NIDDM and non-diabetic individuals. Therefore, the present study indicated that higher frequency unlar loop and hypothenar pattern as well as lower frequency of whorl may be used as a screening tool to identify the person at risk of developing NIDDM.

  8. Dynamic analysis of C/C composite finger seal

    Chen Guoding; Wang Li’na; Yu Qiangpeng; Su Hua

    2014-01-01

    A seal device as an important component of aeroengines has decisive influence on per-formance, reliability, and working life of aeroengines. With the development of aeroengines, demands on the performance characteristics of seal devices are made strictly. Finger seal as a novel kind of sealing device, recently attracts more and more attentions in academic circles and engineer-ing fields at home and abroad. Research on finger seals has been extensively developed, especially on leakage and wear performances under dynamic conditions. However, it is a pity that the work on finger seals has been limited with a single approach that is improving the performance by structural optimization;in addition, the technology of dynamic analysis on finger seals is weak. Aiming at the problems mentioned above, a distributed mass equivalent dynamic model of finger seals considering the coupling effect of overlaid laminates is established in the present paper, the dynamic perfor-mance of 2.5 dimension C/C composite finger seal is analyzed with the model, and then the effects of fiber bundle density and fiber bundle preparation direction on finger seal’s dynamic performance are discussed, as well as compared with those of Co-based alloy finger seal. The current work is about dynamic analysis of finger seals and application of C/C composite in this paper may have much academic significance and many engineering values for improving research level of finger seal dynamics and exploring feasibility of C/C composite being used for finger seals.

  9. Dynamic analysis of C/C composite finger seal

    Chen Guoding

    2014-06-01

    Full Text Available A seal device as an important component of aeroengines has decisive influence on performance, reliability, and working life of aeroengines. With the development of aeroengines, demands on the performance characteristics of seal devices are made strictly. Finger seal as a novel kind of sealing device, recently attracts more and more attentions in academic circles and engineering fields at home and abroad. Research on finger seals has been extensively developed, especially on leakage and wear performances under dynamic conditions. However, it is a pity that the work on finger seals has been limited with a single approach that is improving the performance by structural optimization; in addition, the technology of dynamic analysis on finger seals is weak. Aiming at the problems mentioned above, a distributed mass equivalent dynamic model of finger seals considering the coupling effect of overlaid laminates is established in the present paper, the dynamic performance of 2.5 dimension C/C composite finger seal is analyzed with the model, and then the effects of fiber bundle density and fiber bundle preparation direction on finger seal’s dynamic performance are discussed, as well as compared with those of Co-based alloy finger seal. The current work is about dynamic analysis of finger seals and application of C/C composite in this paper may have much academic significance and many engineering values for improving research level of finger seal dynamics and exploring feasibility of C/C composite being used for finger seals.

  10. Nylon-muscle-actuated robotic finger

    Wu, Lianjun; Jung de Andrade, Monica; Rome, Richard S.; Haines, Carter; Lima, Marcio D.; Baughman, Ray H.; Tadesse, Yonas

    2015-04-01

    This paper describes the design and experimental analysis of novel artificial muscles, made of twisted and coiled nylon fibers, for powering a biomimetic robotic hand. The design is based on circulating hot and cold water to actuate the artificial muscles and obtain fast finger movements. The actuation system consists of a spring and a coiled muscle within a compliant silicone tube. The silicone tube provides a watertight, expansible compartment within which the coiled muscle contracts when heated and expands when cooled. The fabrication and characterization of the actuating system are discussed in detail. The performance of the coiled muscle fiber in embedded conditions and the related characteristics of the actuated robotic finger are described.

  11. Erosion waves: transverse instabilities and fingering

    Malloggi, F.; Lanuza, J.; Andreotti, B.; Clément, E.

    2005-01-01

    Two laboratory scale experiments of dry and under-water avalanches of non-cohesive granular materials are investigated. We trigger solitary waves and study the conditions under which the front is transversally stable. We show the existence of a linear instability followed by a coarsening dynamics and finally the onset of a fingering pattern. Due to the different operating conditions, both experiments strongly differ by the spatial and time scales involved. Nevertheless, the quantitative agree...

  12. A Color Based Touchless Finger Mouse

    Kah-Meng Kwong; Chin-Poo Lee; Kian-Ming Lim; Siew-Chin Chong; Siti Fatimah Abdul Razak

    2012-01-01

    People work with computers almost anytime, everywhere  in the current trend. However, continuously controlling a computer with mouse for a long time might cause much strains to people’s wrist. This work proposes a touchless finger mouse using webcam. A marker with different colours representing different actions is used. The webcam will capture the information on the marker and trigger the associated actions. This prototype is proven to be able to perform most of the actions a normal mouser c...

  13. Viscous fingering in volatile thin films

    Agam, Oded

    2008-01-01

    A thin water film on a cleaved mica substrate undergoes a first order phase transition between two values of film thickness. By inducing a finite evaporation rate of the water, the interface between the two phases develops a fingering instability similar to that observed in the Saffman-Taylor problem. We draw the connection between the two problems, and construct solutions describing the dynamics of evaporation in this system.

  14. Angiolipoma of index finger: A case report

    Muzaffer Durmus

    2016-04-01

    Full Text Available Angiolipomas are usually found in the upper extremities, shoulder and back. They are seldom found in the hands, face and lower extremities. They usually occur as painful soft tissue masses or they may compress the neighboring structures (e.g. nerves depending on the size and location. In this report we present an angiolipoma case located in the finger and discuss related recent cases described in the literature. [Hand Microsurg 2016; 5(1.000: 22-25

  15. Angiolipoma of index finger: A case report

    Muzaffer Durmus; Nuri Yigit; Abdul Kerim Yapici

    2016-01-01

    Angiolipomas are usually found in the upper extremities, shoulder and back. They are seldom found in the hands, face and lower extremities. They usually occur as painful soft tissue masses or they may compress the neighboring structures (e.g. nerves) depending on the size and location. In this report we present an angiolipoma case located in the finger and discuss related recent cases described in the literature. [Hand Microsurg 2016; 5(1.000): 22-25

  16. Ferritin, finger clubbing, and lung disease.

    Shneerson, J M; Jones, B M

    1981-01-01

    The serum ferritin concentration has been determined by an immunoradiometric assay in 90 subjects with a variety of pulmonary diseases. No association between ferritin concentrations and finger clubbing has been found in any of the diseases studied. Ferritin levels were significantly raised in the subjects with bronchial carcinoma, but were not useful in monitoring recurrence of the tumour. Pulmonary artery and pulmonary vein ferritin concentrations were similar to systemic venous concentrati...

  17. Genome Engineering With Zinc-Finger Nucleases

    Carroll, Dana

    2011-01-01

    Zinc-finger nucleases (ZFNs) are targetable DNA cleavage reagents that have been adopted as gene-targeting tools. ZFN-induced double-strand breaks are subject to cellular DNA repair processes that lead to both targeted mutagenesis and targeted gene replacement at remarkably high frequencies. This article briefly reviews the history of ZFN development and summarizes applications that have been made to genome editing in many different organisms and situations. Considerable progress has been mad...

  18. Pacifier Use, Finger Sucking, and Infant Sleep.

    Butler, Rachel; Moore, Melisa; Mindell, Jodi A

    2016-01-01

    Few studies to date have investigated the relationship between pacifier use or finger sucking and infant sleep. One hundred and four mothers of infants (ages 0-11 months) completed the Brief Infant Sleep Questionnaire (BISQ). Infants who engaged in finger sucking had fewer night wakings and longer stretches of nighttime sleep, although less daytime sleep. There were no significant differences in sleep patterns between pacifier users and infants who did not engage in nonnutritive sucking. Furthermore, no significant differences were found across groups for sleep ecology, including parental involvement at bedtime and following night wakings. Finally, infants were consistently able to retrieve their pacifiers independently by 7 months of age, although this did not appear to be associated with sleep outcomes. Results suggest that when parents are deciding whether to give their infant a pacifier, sleep may not be a critical factor. In contrast, parents of finger and thumb suckers should be reassured that this nonnutritive sucking is beneficial to sleep, at least in the first year of life. PMID:26548755

  19. Saffman-Taylor fingers with kinetic undercooling

    Gardiner, Bennett P J; Dallaston, Michael C; Moroney, Timothy J

    2015-01-01

    The mathematical model of a steadily propagating Saffman-Taylor finger in a Hele-Shaw channel has applications to two-dimensional interacting streamer discharges which are aligned in a periodic array. In the streamer context, the relevant regularisation on the interface is not provided by surface tension, but instead has been postulated to involve a mechanism equivalent to kinetic undercooling, which acts to penalise high velocities and prevent blow-up of the unregularised solution. Previous asymptotic results for the Hele-Shaw finger problem with kinetic undercooling suggest that for a given value of the kinetic undercooling parameter, there is a discrete set of possible finger shapes, each analytic at the nose and occupying a different fraction of the channel width. In the limit in which the kinetic undercooling parameter vanishes, the fraction for each family approaches 1/2, suggesting that this 'selection' of 1/2 by kinetic undercooling is qualitatively similar to the well-known analogue with surface tens...

  20. Writing in the Air: Contributions of Finger Movement to Cognitive Processing.

    Yoshihiro Itaguchi

    Full Text Available The present study investigated the interactions between motor action and cognitive processing with particular reference to kanji-culture individuals. Kanji-culture individuals often move their finger as if they are writing when they are solving cognitive tasks, for example, when they try to recall the spelling of English words. This behavior is called kusho, meaning air-writing in Japanese. However, its functional role is still unknown. To reveal the role of kusho behavior in cognitive processing, we conducted a series of experiments, employing two different cognitive tasks, a construction task and a stroke count task. To distinguish the effects of the kinetic aspects of kusho behavior, we set three hand conditions in the tasks; participants were instructed to use either kusho, unrelated finger movements or do nothing during the response time. To isolate possible visual effects, two visual conditions in which participants saw their hand and the other in which they did not, were introduced. We used the number of correct responses and response time as measures of the task performance. The results showed that kusho behavior has different functional roles in the two types of cognitive tasks. In the construction task, the visual feedback from finger movement facilitated identifying a character, whereas the kinetic feedback or motor commands for the behavior did not help to solve the task. In the stroke count task, by contrast, the kinetic aspects of the finger movements influenced counting performance depending on the type of the finger movement. Regardless of the visual condition, kusho behavior improved task performance and unrelated finger movements degraded it. These results indicated that motor behavior contributes to cognitive processes. We discussed possible mechanisms of the modality dependent contribution. These findings might lead to better understanding of the complex interaction between action and cognition in daily life.

  1. Small-scale behavior of single gravity-driven fingers in an initially dry fracture

    Experiments investigating the behavior of individual, gravity-driven fingers in an initially dry, rough-walled analog fracture are presented. Fingers were initiated from constant flow to a point source. Finger structure is described in detail; specific phenomena observed include: desaturation behind the finger-tip, variation in finger path, intermittent flow structures, finger-tip bifurcation, and formation of dendritic sub-fingers. Measurements were made of finger-tip velocity, finger width, and finger-tip length. Non-dimensional forms of the measured variables are analyzed relative to the independent parameters, flow rate and gravitational gradient

  2. The role of fingers in number processing in young children

    Anne eLafay

    2013-07-01

    Full Text Available The aim of the present study was to investigate the relationship between finger counting and numerical processing in 4- to 7-year-old children. Children were assessed on a variety of numerical tasks and we examined the correlations between their rates of success and their frequency of finger use in a counting task. We showed that children’s performance on finger pattern comparison and identification tasks did not correlate with the frequency of finger use. However, this last variable correlated with the percentages of correct responses in an enumeration task (i.e., Give-N task, even when the age of children was entered as a covariate in the analysis. Despite this correlation, we showed that some children who never used their fingers in the counting task were able to perform optimally in the enumeration task. Overall, our results support the conclusion that finger counting is useful but not necessary to develop accurate symbolic numerical skills. Moreover, our results suggest that the use of fingers in a counting task is related to the ability of children in a dynamic enumeration task but not to static tasks involving recognition or comparison of finger patterns. Therefore, it could be that the link between fingers and numbers remain circumscribed to counting tasks and do not extent to static finger montring situations.

  3. VISIONS FOR FOOTWEAR TIP SHAPE ACCORDING TO THE CONFIGURATION FINGER

    MALCOCI Marina

    2015-05-01

    Full Text Available Compatibility between the consumer and the interior leg permanent footwear raises a number of issues. And any new form of footwear is time for a new silhouette last. Fashion is a factor in determining the shape of the last significant role. The most important influence on fashion in footwear that has at one time is found in peak shape. During registered a variety of forms leading to the last, for example, pointed, oval, round, square, asymmetrical, curved, trapezoidal, etc. Each has added a tip top recommended. The paper analyzes the morphofunctional characteristic, namely, finger configuration. The configuration of the fingers is determined from the positions of all the fingers of one another, as are six variants. Analysis of the shape and configuration of the arm fingers allow us to make the following recommendations to consumers: people showing finger configuration as in variant V and VI are advised not to wear pointy shoes because of the limited movement of the foot, which favors the diversion finger I exterior and deformed finger V; persons who fall within I-IV variant can procure pointy shoes; a round-tipped shoes, square, curved or asymmetric may be purchased by any consumer regardless of the configuration of the fingers; shoes with cut edge must be present only in garderopa people in variant I and II; consumers whose configuration is like finger-VI and III variants are awkwardly shaped fingers can buy shoes closed in the previous summer, but of different perforations or overlapping strips.

  4. Torque Control of Underactuated Tendon-driven Robotic Fingers

    Abdallah, Muhammad E. (Inventor); Ihrke, Chris A. (Inventor); Reiland, Matthew J. (Inventor); Wampler, Charles W. (Inventor); Diftler, Myron A. (Inventor); Platt, Robert (Inventor); Bridgwater, Lyndon (Inventor)

    2013-01-01

    A robotic system includes a robot having a total number of degrees of freedom (DOF) equal to at least n, an underactuated tendon-driven finger driven by n tendons and n DOF, the finger having at least two joints, being characterized by an asymmetrical joint radius in one embodiment. A controller is in communication with the robot, and controls actuation of the tendon-driven finger using force control. Operating the finger with force control on the tendons, rather than position control, eliminates the unconstrained slack-space that would have otherwise existed. The controller may utilize the asymmetrical joint radii to independently command joint torques. A method of controlling the finger includes commanding either independent or parameterized joint torques to the controller to actuate the fingers via force control on the tendons.

  5. Comparison of the plaque removal efficacy of a new flossing aid (Quik Floss) to finger flossing.

    Carter-Hanson, C; Gadbury-Amyot, C; Killoy, W

    1996-09-01

    The purpose of this clinical trial was to compare the effectiveness and safety of a new dental flossing device (Quik Floss) to finger flossing in plaque removal, reduction of gingival inflammation and patient preference. 30 healthy, non-flossing adults with 20 natural teeth, a plaque index (PI) of at least 1.8 and a gingival index (GI) of 1.3 or greater participated in this two-phase crossover design study. Patients were randomly assigned to use either the new flossing device or finger flossing first in the sequence. At baseline, data were collected and patients were given flossing method instructions. The Silness & Löe GI, Quigley-Hein PI, Eastman Bleeding Index (BI) and trauma were assessed at baseline, 15 and 30 days for each treatment period. After the initial 30-day treatment phase, patients were instructed to cease all flossing during a 14-day "washout" period. Subjects were then assigned to the opposite treatment group during the 2nd treatment phase. A 3-factor repeated measures ANOVA analyzed data for differences within and between groups over time. Results revealed statistically significant (p Floss was as effective as finger flossing. Subjects preferred (55%) Quik Floss over finger flossing. In conclusion, Quik Floss is a safe and effective oral hygiene measure for reducing plaque, inflammation and bleeding over time. PMID:8891940

  6. Cells in the monkey ponto-medullary reticular formation modulate their activity with slow finger movements.

    Soteropoulos, Demetris S; Williams, Elizabeth R; Baker, Stuart N

    2012-08-15

    Recent work has shown that the primate reticulospinal tract can influence spinal interneurons and motoneurons involved in control of the hand. However, demonstrating connectivity does not reveal whether reticular outputs are modulated during the control of different types of hand movement. Here, we investigated how single unit discharge in the pontomedullary reticular formation (PMRF) modulated during performance of a slow finger movement task in macaque monkeys. Two animals performed an index finger flexion–extension task to track a target presented on a computer screen; single units were recorded both from ipsilateral PMRF (115 cells) and contralateral primary motor cortex (M1, 210 cells). Cells in both areas modulated their activity with the task (M1: 87%, PMRF: 86%). Some cells (18/115 in PMRF; 96/210 in M1) received sensory input from the hand, showing a short-latency modulation in their discharge following a rapid passive extension movement of the index finger. Effects in ipsilateral electromyogram to trains of stimuli were recorded at 45 sites in the PMRF. These responses involved muscles controlling the digits in 13/45 sites (including intrinsic hand muscles, 5/45 sites). We conclude that PMRF may contribute to the control of fine finger movements, in addition to its established role in control of more proximal limb and trunk movements. This finding may be especially important in understanding functional recovery after brain lesions such as stroke. PMID:22641776

  7. Improving esthetics of finger prosthesis by glove silicone

    Laxman Singh Kaira; Esha Dabral

    2014-01-01

    Finger and partial finger amputations are some of the most frequently encountered forms of partial hand loss. A high quality esthetic prosthesis with passive function can be helpful to the patient since loss or congenital absence or malformation have both a social and psychological impact on the patient. Prosthetics is an art and science, which provides lifelike appearance to the lost structures of the patient. This case report presents the fabrication of a silicone finger prosthesis, which h...

  8. Fingering instabilities in Newtonian and non-Newtonian fluids

    Kennedy, Kristi E.

    Fingering has been studied in different fluid systems. Viscous fingering, which is driven by a difference in viscosity between fluids, has been studied by both experiments and numerical simulations. We used a single fluid with a temperature-dependent viscosity and studied the instability for a range of inlet pressures and viscosity ratios. The spreading and fingering of a fluid drop subjected to a centrifugal force, known as spin coating, has also been studied for a range of drop volumes and rotation speeds, both for a Newtonian and a non-Newtonian fluid. Experiments on viscous fingering with a single fluid, glycerine, show that an instability occurs at the boundary separating hot and cold fluid. The results indicate that the instability is similar to that which occurs between two miscible fluids. Fingering only occurs for high enough values of the inlet pressure and viscosity ratio. The wavelength of the fingering pattern is found to be proportional to the cell width for the two smallest cell widths used. The fingering patterns seen in the simulations are very similar to the experimental patterns, although there are some quantitative differences. In particular, the wavelength of the instability is seen to depend only weakly on the cell width. The spreading of silicone oil, a Newtonian fluid, during spin coating follows the time dependence predicted theoretically, although with a shift in the scaled time variable. Once the radius of the spreading silicone oil drop becomes large enough, fingers form around the perimeter of the drop for all experimental conditions studied. The number of fingers and the growth rate of the fingers are in agreement with theoretical predictions. Fingers are also observed to form for high enough drop volumes and rotation speeds during the spinning of a non-Newtonian fluid drop, Carbopol, which possesses a yield stress. In this case the fingering is a localized effect, occuring once the stress on the drop exceeds the yield stress, rather

  9. Effective Length Design of Humanoid Robot Fingers Using Biomimetic Optimization

    Byoung-Ho Kim

    2015-01-01

    In this study, we propose an effective design method for the phalangeal parameters and the total size of humanoid robot fingers based on a biomimetic optimization. For the optimization, an interphalangeal joint coordination parameter and the length constraints inherent in human fingers are considered from a biomimetic perspective. A reasonable grasp formulation is also taken into account from the viewpoint of power grasping, where the grasp space of a humanoid robot finger is importantly cons...

  10. Forced ventilation increases variability of isometric finger forces

    Li, Sheng; Yasuda, Nobuo

    2006-01-01

    The study aimed to assess the effects of forced ventilation on variability of the index finger force at the submaximal levels. Fourteen (6 men, 8 women) healthy subjects were instructed to perform self-initiated forced inspiration and forced expiration, the Valsalva maneuver and normal breathing while sustaining 15%, 30%, and 45% of maximal voluntary contraction (MVC) by the index finger. Standard deviation (S.D.) of finger forces increased significantly with the level of force. At each level...

  11. Finteraction : Finger Interaction with Mobile Phone

    Jenabi, Mahsa; Reiterer, Harald

    2008-01-01

    Touch interaction with mobile phones enable users to have a more natural interaction with the device, since touch is a natural way of direct accessing an ob ject of interest. But one disadvantage is occlusion; i.e., the user loses a high percentage of information presented on the small screen of the mobile phone during the interaction using his big finger . On the other hand, interaction enhanced with accelerometers can react according to the device movements, e.g., while the user is tilting...

  12. A Color Based Touchless Finger Mouse

    Kah-Meng Kwong

    2012-01-01

    Full Text Available People work with computers almost anytime, everywhere  in the current trend. However, continuously controlling a computer with mouse for a long time might cause much strains to people’s wrist. This work proposes a touchless finger mouse using webcam. A marker with different colours representing different actions is used. The webcam will capture the information on the marker and trigger the associated actions. This prototype is proven to be able to perform most of the actions a normal mouser can perform.

  13. Tetanus following replantation of an amputated finger: a case report

    Hayashida Kenji

    2012-10-01

    Full Text Available Abstract Introduction Tetanus is an infectious disease caused by tetanus toxin produced by Clostridium tetani and induces severe neurological manifestations. We treated a patient who developed tetanus during hospitalization for replantation of an amputated finger. To the best of our knowledge, this is the first published case report of such an entity. Case presentation A 49-year-old Japanese man had an amputation of his right middle finger at the distal interphalangeal joint region in an accident at work. His middle finger was successfully replanted, but his fingertip was partially necrotized because of crushing and so additional reconstruction with a reverse digital arterial flap was performed 15 days after the injury. Tetanus developed 21 days after replantation of the middle finger, but symptoms remitted via rapid diagnosis and treatment. Conclusions In replantation after finger trauma with exposure of nerve and blood vessel bundles, concern over injuring nerves and blood vessels may prevent irrigation and debridement from being performed sufficiently; these treatments may have been insufficiently performed in this patient. It is likely that the replanted middle finger partially adhered, and Clostridium tetani colonized the partially necrotized region. Even when there is only limited soil contamination, administration of tetanus toxoid and anti-tetanus immunoglobulin is necessary when the fingers are injured outdoors and the finger nerves and blood vessels are exposed. The drugs should be administered just after replantation if the finger has been amputated. However, if clinicians pay attention to the possibility of tetanus development, treatment can be rapidly initiated.

  14. Effect of Finger Joint on Flexural Strength of Teak Wood

    Bharatesh A. Danawade

    2014-01-01

    Full Text Available This paper presents the flexural properties of rectangular Burma teak wood beam without finger joint and with finger joint. Finger joints enable full utilization of wood. Finger jointing technique is also used to eliminate wood defects which weaken the strength of wood. This paper considers finger joint as defined defect and its effect on the flexural strength is determined. Teakwood is hard and heavy, seasons rapidly and has good durability. The specimens were studied under three point bending test. Both edge wise and flat wise tests were carried out. It is observed that Burma teakwood beam without finger joint is stronger than beams with finger joints. Because of finger jointing the flexural strength reduces. It can be concluded that the strength loss can improved upon by selecting suitable geometry of finger joint and a suitable adhesive. It is recognized that further studies are necessary on jointing techniques of wood and type of adhesive so as to equal the flexural strength properties of clear teak wood beams.

  15. The design and development of a finger joint simulator.

    Joyce, Thomas J

    2016-05-01

    Artificial finger joints lack the long-term clinical success seen with hip and knee prostheses. In part, this can be explained by the challenges of rheumatoid arthritis, a progressive disease which attacks surrounding tissues as well as the joint itself. Therefore, the natural finger joints' biomechanics are adversely affected, and consequently, this imbalance due to subluxing forces further challenges any prosthesis. Many different designs of finger prosthesis have been offered over a period of greater than 50 years. Most of these designs have failed, and it is likely that many of these failures could have been identified had the prostheses been appropriately tested prior to implantation into patients. While finger joint simulators have been designed, arguably only those from a single centre have been able to reproduce clinical-type failures of the finger prostheses tested in them. This article describes the design and development of a finger simulator at Durham University, UK. It explains and justifies the engineering decisions made and thus the evolution of the finger simulator. In vitro results and their linkage to clinical-type failures are outlined to help to show the effectiveness of the simulator. Failures of finger implants in vivo continue to occur, and the need for appropriate in vitro testing of finger prostheses remains strong. PMID:26833697

  16. Extrinsic versus intrinsic hand muscle dominance in finger flexion.

    Al-Sukaini, A; Singh, H P; Dias, J J

    2016-05-01

    This study aims to identify the patterns of dominance of extrinsic or intrinsic muscles in finger flexion during initiation of finger curl and mid-finger flexion. We recorded 82 hands of healthy individuals (18-74 years) while flexing their fingers and tracked the finger joint angles of the little finger using video motion tracking. A total of 57 hands (69.5%) were classified as extrinsic dominant, where the finger flexion was initiated and maintained at proximal interphalangeal and distal interphalangeal joints. A total of 25 (30.5%) were classified as intrinsic dominant, where the finger flexion was initiated and maintained at the metacarpophalangeal joint. The distribution of age, sex, dominance, handedness and body mass index was similar in the two groups. This knowledge may allow clinicians to develop more efficient rehabilitation regimes, since intrinsic dominant individuals would not initiate extrinsic muscle contraction till later in finger flexion, and might therefore be allowed limited early active motion. For extrinsic dominant individuals, by contrast, initial contraction of extrinsic muscles would place increased stress on the tendon repair site if early motion were permitted. PMID:26744509

  17. Cells in the monkey ponto-medullary reticular formation modulate their activity with slow finger movements

    Soteropoulos, Demetris S.; Williams, Elizabeth R.; Baker, Stuart N.

    2012-01-01

    Recent work has shown that the primate reticulospinal tract can influence spinal interneurons and motoneurons involved in control of the hand. However, demonstrating connectivity does not reveal whether reticular outputs are modulated during the control of different types of hand movement. Here, we investigated how single unit discharge in the pontomedullary reticular formation (PMRF) modulated during performance of a slow finger movement task in macaque monkeys. Two animals performed an inde...

  18. Dorso-palmar triangular finger flap-A new advancement flap for cover of finger amputations-A preliminary report

    Mishra Satyanarayan

    2001-01-01

    Full Text Available A triangular V-Y type advancement flap on the finger has been designed, which advances skin from over the whole circumference of the finger, which includes both palmar and dorsal skin. The flap is sensate too. It is indicated for finger and thumb amputations proximal to the body of the nail. Six flaps were raised with five successes and one partial necrosis. This is a preliminary report on a new flap.

  19. Teleoperation of Robonaut Using Finger Tracking

    Champoux, Rachel G.; Luo, Victor

    2012-01-01

    With the advent of new finger tracking systems, the idea of a more expressive and intuitive user interface is being explored and implemented. One practical application for this new kind of interface is that of teleoperating a robot. For humanoid robots, a finger tracking interface is required due to the level of complexity in a human-like hand, where a joystick isn't accurate. Moreover, for some tasks, using one's own hands allows the user to communicate their intentions more effectively than other input. The purpose of this project was to develop a natural user interface for someone to teleoperate a robot that is elsewhere. Specifically, this was designed to control Robonaut on the international space station to do tasks too dangerous and/or too trivial for human astronauts. This interface was developed by integrating and modifying 3Gear's software, which includes a library of gestures and the ability to track hands. The end result is an interface in which the user can manipulate objects in real time in the user interface. then, the information is relayed to a simulator, the stand in for Robonaut, at a slight delay.

  20. Lipid Gymnastics: Tethers and Fingers in membrane

    Tayebi, Lobat; Miller, Gregory; Parikh, Atul

    2009-03-01

    A significant body of evidence now links local mesoscopic structure (e.g., shape and composition) of the cell membrane with its function; the mechanisms by which cellular membranes adopt the specific shapes remain poorly understood. Among all the different structures adopted by cellular membranes, the tubular shape is one of the most surprising one. While their formation is typically attributed to the reorganization of membrane cytoskeleton, many exceptions exist. We report the instantaneous formation of tubular membrane mesophases following the hydration under specific thermal conditions. The shapes emerge in a bimodal way where we have two distinct diameter ranges for tubes, ˜20μm and ˜1μm, namely fat fingers and narrow tethers. We study the roughening of hydrated drops of 3 lipids in 3 different spontaneous curvatures at various temp. and ionic strength to figure out the dominant effect in selection of tethers and fingers. Dynamics of the tubes are of particular interest where we observe four distinct steps of birth, coiling, uncoiling and retraction with different lifetime on different thermal condition. These dynamics appear to reflect interplay between membrane elasticity, surface adhesion, and thermal or hydrodynamic gradient.

  1. Cholinergic vasodilator mechanism in human fingers

    The effect of a cholinergic agonist and antagonist on finger blood flow (FBF) was studied in 10 normal subjects. Total finger blood flow was measured by venous occlusion, air plethysmography, and capillary blood flow (FCF) by the disappearance rate of a radio-isotope from a fingertip injection. Methacholine in doses of 10-80 μg/min was given by constant infusion via a brachial artery catheter. Average FBF and vascular resistance were not significantly affected. However, the half time (t/sub 1/2/) of the disappearance rate decreased from 50.8 +/- 13.4 to 11.1 +/- 1.5 min; a decrease occurred in all subjects. In seven subjects, atropine (0.2 mg) had no affect alone but inhibited the effect of methacholine on FCF and prevented the redness and sweating of the forearm and hand that occurs with this agent. This study demonstrates a muscarinic cholinergic vasodilator mechanism in the fingertip that uniquely increase capillary blood flow

  2. Cholinergic vasodilator mechanism in human fingers

    Coffman, J.D.; Cohen, R.A.

    1987-03-01

    The effect of a cholinergic agonist and antagonist on finger blood flow (FBF) was studied in 10 normal subjects. Total finger blood flow was measured by venous occlusion, air plethysmography, and capillary blood flow (FCF) by the disappearance rate of a radio-isotope from a fingertip injection. Methacholine in doses of 10-80 ..mu..g/min was given by constant infusion via a brachial artery catheter. Average FBF and vascular resistance were not significantly affected. However, the half time (t/sub 1/2/) of the disappearance rate decreased from 50.8 +/- 13.4 to 11.1 +/- 1.5 min; a decrease occurred in all subjects. In seven subjects, atropine (0.2 mg) had no affect alone but inhibited the effect of methacholine on FCF and prevented the redness and sweating of the forearm and hand that occurs with this agent. This study demonstrates a muscarinic cholinergic vasodilator mechanism in the fingertip that uniquely increase capillary blood flow.

  3. Rehabilitation for bilateral amputation of fingers

    Stapanian, Martin A.; Stapanian, Adrienne M.P.; Staley, Keith E.

    2010-01-01

    We describe reconstructive surgeries, therapy, prostheses, and adaptations for a patient who experienced bilateral amputation of all five fingers of both hands through the proximal phalanges in January 1992. The patient made considerable progress in the use of his hands in the 10 mo after amputation, including nearly a 120% increase in the active range of flexion of metacarpophalangeal joints. In late 1992 and early 1993, the patient had "on-top plasty" surgeries, in which the index finger remnants were transferred onto the thumb stumps, performed on both hands. The increased web space and functional pinch resulting from these procedures made many tasks much easier. The patient and occupational therapists set challenging goals at all times. Moreover, the patient was actively involved in the design and fabrication of all prostheses and adaptations or he developed them himself. Although he was discharged from occupational therapy in 1997, the patient continues to actively find new solutions for prehension and grip strength 18 yr after amputation.

  4. Finger-like voids induced by viscous fingering during phase inversion of alumina/PES/NMP suspensions

    Wang, Bo

    2012-07-01

    The formation mechanism of phase-inversion ceramic hollow fibre membranes has not been well understood. In this paper, we report on the formation of finger-like macrovoids during non-solvent-induced phase inversion of alumina/PES/NMP suspensions. A membrane structure without such finger-like macrovoids was observed when the suspension was slowly immersed into pure ethanol or a mixture of 70. wt% NMP and 30. wt% water, whereas finger-like macrovoids occurred when the suspension was slid into the non-solvents at higher speeds. We found that the formation process of finger-like macrovoids could be fully or partially reversed when nascent membranes were taken out from water shortly after immersion, depending on the duration of the immersion. Splitting of the fingers during the formation of the macrovoids was also observed during the phase inversion of two alumina/PES/NMP suspensions. These experimental observations were not predicted by current theories of finger-like macrovoid formation in polymer membranes, but appear to mimic the well-known viscous fingering phenomenon. We therefore propose that in the phase inversion of ceramic suspensions, the viscous fingering phenomenon is an important mechanism in the formation of finger-like voids. © 2012 Elsevier B.V.

  5. Finger curvature movement recognition interface technique using SEMG signals

    Y. Itoh

    2007-08-01

    Full Text Available Purpose: Until recently, keyboard has been used as the primary input method for machinery operation system. But in recent years, numerous methods related to direct input interface have been developed. One of them is to measure the surface electric potential that generates on the skin surface during muscle contraction. Based on this fact, hand finger operation can also be recognized with the help of the surface muscle electric potential. The purpose of this study is to identify the hand finger operation using surface electromyogram (SEMG during crookedness state of the finger.Design/methodology/approach: Two electrodes (Ag-AgCl electrode were sticked randomly on the forearm muscles and the intensity of EMG signals at different muscles were measured for each crooked finger. Then depending on the intensity of the obtained electric potentials, a position was located and considered to have participated most actively during the crookedness state of that finger. Thus five locations on the forearm muscles were identified for five different fingers. Moreover, four different types of crookedness states were considered for each finger.Findings: In this experimental study, the electric current that generates on the skin during muscle activity was measured for different hand finger operations. As a result, it is found that there is a specified position related to the maximum intensity of EMG signals for each finger. Practical implications: This paper cleared that the amount of crookedness of each finger can also be recognized with the help of surface EMG. It could be used as a machine interface technology in the field of welfare equipments, robot hand operation, virtual reality, etc.Originality/value: The objective of this research project was to develop the method of recognizing the hand finger operation and their crookedness states from surface electromyogram (SEMG.

  6. Identification of SNP and SSR Markers in Finger Millet Using Next Generation Sequencing Technologies

    Gimode, Davis; Odeny, Damaris A.; de Villiers, Etienne P.; Wanyonyi, Solomon; Dida, Mathews M.; Mneney, Emmarold E.; Muchugi, Alice; Machuka, Jesse; de Villiers, Santie M.

    2016-01-01

    Finger millet is an important cereal crop in eastern Africa and southern India with excellent grain storage quality and unique ability to thrive in extreme environmental conditions. Since negligible attention has been paid to improving this crop to date, the current study used Next Generation Sequencing (NGS) technologies to develop both Simple Sequence Repeat (SSR) and Single Nucleotide Polymorphism (SNP) markers. Genomic DNA from cultivated finger millet genotypes KNE755 and KNE796 was sequenced using both Roche 454 and Illumina technologies. Non-organelle sequencing reads were assembled into 207 Mbp representing approximately 13% of the finger millet genome. We identified 10,327 SSRs and 23,285 non-homeologous SNPs and tested 101 of each for polymorphism across a diverse set of wild and cultivated finger millet germplasm. For the 49 polymorphic SSRs, the mean polymorphism information content (PIC) was 0.42, ranging from 0.16 to 0.77. We also validated 92 SNP markers, 80 of which were polymorphic with a mean PIC of 0.29 across 30 wild and 59 cultivated accessions. Seventy-six of the 80 SNPs were polymorphic across 30 wild germplasm with a mean PIC of 0.30 while only 22 of the SNP markers showed polymorphism among the 59 cultivated accessions with an average PIC value of 0.15. Genetic diversity analysis using the polymorphic SNP markers revealed two major clusters; one of wild and another of cultivated accessions. Detailed STRUCTURE analysis confirmed this grouping pattern and further revealed 2 sub-populations within wild E. coracana subsp. africana. Both STRUCTURE and genetic diversity analysis assisted with the correct identification of the new germplasm collections. These polymorphic SSR and SNP markers are a significant addition to the existing 82 published SSRs, especially with regard to the previously reported low polymorphism levels in finger millet. Our results also reveal an unexploited finger millet genetic resource that can be included in the regional

  7. Finger-powered microfluidic systems using multilayer soft lithography and injection molding processes.

    Iwai, Kosuke; Shih, Kuan Cheng; Lin, Xiao; Brubaker, Thomas A; Sochol, Ryan D; Lin, Liwei

    2014-10-01

    Point-of-care (POC) and disposable biomedical applications demand low-power microfluidic systems with pumping components that provide controlled pressure sources. Unfortunately, external pumps have hindered the implementation of such microfluidic systems due to limitations associated with portability and power requirements. Here, we propose and demonstrate a 'finger-powered' integrated pumping system as a modular element to provide pressure head for a variety of advanced microfluidic applications, including finger-powered on-chip microdroplet generation. By utilizing a human finger for the actuation force, electrical power sources that are typically needed to generate pressure head were obviated. Passive fluidic diodes were designed and implemented to enable distinct fluids from multiple inlet ports to be pumped using a single actuation source. Both multilayer soft lithography and injection molding processes were investigated for device fabrication and performance. Experimental results revealed that the pressure head generated from a human finger could be tuned based on the geometric characteristics of the pumping system, with a maximum observed pressure of 7.6 ± 0.1 kPa. In addition to the delivery of multiple, distinct fluids into microfluidic channels, we also employed the finger-powered pumping system to achieve the rapid formation of both water-in-oil droplets (106.9 ± 4.3 μm in diameter) and oil-in-water droplets (75.3 ± 12.6 μm in diameter) as well as the encapsulation of endothelial cells in droplets without using any external or electrical controllers. PMID:25102160

  8. Detection of finger gesture using singular spectrum transformation

    The purpose of this study is to detect finger movement using a singular spectrum transformation method. Human gesture recognition is essential for realizing natural user interfaces. However, constructing a robust, easily installable interface is extremely difficult. Our proposed method uses singular spectrum transformation to classify finger movements. This method robustly classifies gestures and behavior

  9. 21 CFR 888.3230 - Finger joint polymer constrained prosthesis.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Finger joint polymer constrained prosthesis. 888... constrained prosthesis. (a) Identification. A finger joint polymer constrained prosthesis is a device intended... generic type of device includes prostheses that consist of a single flexible across-the-joint...

  10. Melorheostosis of the index finger: a case report

    Quarles, Ellen K.; Richardson, Michael L.

    2015-01-01

    We describe a case of melorheostosis involving multiple bones of the left index finger. This patient presented with a many-year history of a finger mass, and demonstrated the typical radiographic findings of melorheostosis on radiographs and computed tomography (CT) of the hand. Following excisional biopsy and bone grafting, this patient is doing well and undergoing physical therapy.

  11. Effect of bending pattern on finger joint bending strength

    Džinčić Igor

    2012-01-01

    Full Text Available Limited information is available on end gluing hardwoods in contrast to softwoods, which have been extensively investigated. The objective of this study was to examine the influence of bending patern on bending strength of finger jointed beech wood. In structural uses finger jointing is finally the major method to end joint timber for the production of glue-laminated elements. There are no bending strength experimental results for finger-jointed hardwoods for investigations conducted in Serbia. Two finger jointed profiles were studied in accordance with DIN68140. The finger joints were made by side and by face of beam. Length jointed samples were loaded at the side and in the face. The obtained results led to the conclusion that the direction of load, gluing surface and the position of joint influence on the strength of continued longitudinal beams.

  12. A new algorithmic approach for fingers detection and identification

    Mubashar Khan, Arslan; Umar, Waqas; Choudhary, Taimoor; Hussain, Fawad; Haroon Yousaf, Muhammad

    2013-03-01

    Gesture recognition is concerned with the goal of interpreting human gestures through mathematical algorithms. Gestures can originate from any bodily motion or state but commonly originate from the face or hand. Hand gesture detection in a real time environment, where the time and memory are important issues, is a critical operation. Hand gesture recognition largely depends on the accurate detection of the fingers. This paper presents a new algorithmic approach to detect and identify fingers of human hand. The proposed algorithm does not depend upon the prior knowledge of the scene. It detects the active fingers and Metacarpophalangeal (MCP) of the inactive fingers from an already detected hand. Dynamic thresholding technique and connected component labeling scheme are employed for background elimination and hand detection respectively. Algorithm proposed a new approach for finger identification in real time environment keeping the memory and time constraint as low as possible.

  13. Geometric approach to viscous fingering on a cone

    We study fluid flow and the formation of viscous fingering patterns on a two-dimensional conical background space, defined as the conical Hele-Shaw cell. We approach the problem geometrically and study how the nontrivial topological structure of the conical cell affects the evolution of the interface separating two viscous fluids. We perform a perturbative weakly nonlinear analysis of the problem and derive a mode-coupling differential equation which describes fluid-fluid interface behaviour. Our nonlinear study predicts the formation of fingering structures in which fingers of different lengths compete and split at their tips. The shape of the emerging patterns show a significant sensitivity to variations in the cell's topological features, which can be monitored by changing the cone opening angle. We find that for increasingly larger values of the opening angle, finger competition is inhibited while finger tip-splitting is enhanced

  14. Surface Tension and Fingering of Miscible Interfaces

    Abib, Mohammed; Liu, Jian-Bang; Ronney, Paul D.

    1999-01-01

    Experiments on miscible, buoyantly unstable reaction-diffusion fronts and non-reacting displacement fronts in Hele-Shaw cells show a fingering-type instability whose wavelengths (lambda*) are consistent with an interfacial tension (sigma) at the front caused by the change in chemical composition, even though the solutions are miscible in all proportions. In conjunction with the Saffman-Taylor model, the relation sigma = K/tau, where tau is the interface thickness and K approximately equal 4 +/- 2 x 10(exp -6) dyne, enables prediction of our measured values of lambda* as well as results from prior experiments on miscible interfaces. These results indicate that even for miscible fluids, surface tension is generally a more significant factor than diffusion in interfacial stability and flow characteristics.

  15. The Silent Language of Fingers and Hands-The Role of Finger and Hand Motions in Non-verbal Communication

    周樱

    2013-01-01

    This paper engages in the discussion about nonverbal intercultural communication from the perspective of hand and finger gestures, probing into the functions of non-verbal cues in cross-cultural interaction, talking over two different attitudes to⁃ward gestures, and giving a detailed analysis about the silent language of some specific gestures with fingers and hands in different cultures.

  16. Increasing substrate resistance to improve the turn-on uniformity of a high-voltage multi-finger GG-nLDMOS

    He Chuan; Jiang Lingli; Fan Hang; Zhang Bo

    2013-01-01

    With the impact of the non-uniform turn-on phenomenon,the ESD robustness of high-voltage multi-finger devices is limited.This paper describes the operational mechanism of a GG-nLDMOS device under ESD stress conditions and analyzes the reason that causes the non-uniform turn-on characteristics of a multi-finger GG-nLDMOS device.By means of increasing substrate resistance,an optimized device structure is proposed to improve the turn-on uniformity of a high-voltage multi-finger GG-nLDMOS.This approach has been successfully verified in a 0.35 μm 40 V BCD process.The TLP test results reveal that increasing the substrate resistance can effectively enhance the turn-on uniformity of the 40 V multi-finger GG-nLDMOS device and improve its ESD robustness.

  17. Torque control of underactuated tendon-driven fingers

    M. E. Abdallah

    2011-02-01

    Full Text Available Given an underactuated tendon-driven finger, the finger posture is underdetermined and can move freely ("flop" in a region of slack tendons. This work shows that such an underactuated finger can be operated in tendon force control (rather than position control with effective performance. The force control eliminates the indeterminate slack while commanding a parameterized space of desired torques. The torque will either push the finger to the joint limits or wrap around an external object with variable torque – behavior that is sufficient for primarily gripping fingers. In addition, introducing asymmetric joint radii to the design allows the finger to command an expanded range of joint torques and to scan an expanded set of external surfaces. This study is motivated by the design and control of the secondary fingers of the NASA-GM R2 humanoid hand.

    This paper was presented at the IFToMM/ASME International Workshop on Underactuated Grasping (UG2010, 19 August 2010, Montréal, Canada.

  18. A reduced model for fingering instability in miscible displacement

    The classical problem of fingering instability in miscible displacement is revisited. The finger-forming dynamics is considered as a multiple-scale process involving a thin inter-diffusion layer and large-scale background flow affected by the viscosity and/or density stratification. Upon an appropriate separation of 'fast' and 'slow' variables one ends up with a reduced model dealing directly with the evolving displacement front. As an illustration, the new model is applied for description of fingering in a source-supported flow and in a flow within a vertical channel

  19. Dorsal finger texture recognition: Investigating fixed-length SURF

    Hartung, Daniel; Kückelhahn, Jesper

    2012-01-01

    We seek to create fixed-length features from dorsal finger skin images extracted by the SURF interest point detector to combine it in the privacy enhancing helper data scheme. The source of the biometric samples is the GUC45 database which features finger vein, fingerprint and dorsal finger skin...... images for modality fusion. First, the region of interest (ROI) is extracted, after which SURF features are extracted, and finally two different approaches for creating fixed length feature vectors are applied. SURF performance on the ROI is comparable to the PolyU database reported in the literature...

  20. A hierarchical classification method for finger knuckle print recognition

    Kong, Tao; Yang, Gongping; Yang, Lu

    2014-12-01

    Finger knuckle print has recently been seen as an effective biometric technique. In this paper, we propose a hierarchical classification method for finger knuckle print recognition, which is rooted in traditional score-level fusion methods. In the proposed method, we firstly take Gabor feature as the basic feature for finger knuckle print recognition and then a new decision rule is defined based on the predefined threshold. Finally, the minor feature speeded-up robust feature is conducted for these users, who cannot be recognized by the basic feature. Extensive experiments are performed to evaluate the proposed method, and experimental results show that it can achieve a promising performance.

  1. Narrow fingers in the Saffman-Taylor instability

    Couder, Y.; Gerard, N.; Rabaud, M.

    1986-12-01

    Saffman-Taylor fingers with a relative width much smaller than the classical limit lambda = 0.5 are found when a small isolated bubble is located at their tip. These solutions are members of a family found by Saffman and Taylor (1958) neglecting superficial tension. Recent theories have shown that when capillary forces are taken into account an unphysical cusplike singularity would appear at the tip of all the fingers with lambda less than 0.5. Conversely, here the replacement of the tip by a small bubble makes these solutions possible. At large velocity these fingers show dendritic instability.

  2. Finger Movement Based Wearable Communication & Navigation Aid for partially disabled

    Jobin Jose

    2016-02-01

    Full Text Available The FMBWCN Aid is a portable and wearable multi-purpose system for the partially disabled. The Aid is a glove-based system in which different trained finger movements leads to different modes of operation of the system such as APR Voice Module and Wheelchair Controller Module. The finger movements (bending movement leads to the flexion of the flex sensor attached to the glove. Flexion leads to change in resistance of the flex sensors, which will be recorded via a microcontroller (Arduino Uno and different sets of movement of the fingers will lead to different modules of operation as specified in the default settings of the FMBWCN Aid.

  3. Finger Length Ratios in Serbian Transsexuals

    Vujović, Svetlana; Popović, Srdjan; Mrvošević Marojević, Ljiljana; Ivović, Miomira; Tančić-Gajić, Milina; Stojanović, Miloš; Marina, Ljiljana V.; Barać, Marija; Barać, Branko; Kovačević, Milena; Duišin, Dragana; Barišić, Jasmina; Djordjević, Miroslav L.; Micić, Dragan

    2014-01-01

    Atypical prenatal hormone exposure could be a factor in the development of transsexualism. There is evidence that the 2nd and 4th digit ratio (2D : 4D) associates negatively with prenatal testosterone and positively with estrogens. The aim was to assess the difference in 2D : 4D between female to male transsexuals (FMT) and male to female transsexuals (MFT) and controls. We examined 42 MFT, 38 FMT, and 45 control males and 48 control females. Precise measurements were made by X-rays at the ventral surface of both hands from the basal crease of the digit to the tip using vernier calliper. Control male and female patients had larger 2D : 4D of the right hand when compared to the left hand. Control male's left hand ratio was lower than in control female's left hand. There was no difference in 2D : 4D between MFT and control males. MFT showed similar 2D : 4D of the right hand with control women indicating possible influencing factor in embryogenesis and consequently finger length changes. FMT showed the lowest 2D : 4D of the left hand when compared to the control males and females. Results of our study go in favour of the biological aetiology of transsexualism. PMID:24982993

  4. YIELD, QUALITY AND NUTRIENT UPTAKE AS INFLUENCED BY ORGANIC MANURES AND INORGANIC FERTILIZERS IN FINGER MILLET

    B Vajantha

    2015-07-01

    Full Text Available A field experiment was conducted to study the influence of organic manures and chemical fertilizers on yield, nutrient uptake by finger millet and soil fertility status at harvest during kharif 2013 at Agricultural Research Station, Perumallapalle, ANGRAU. The results revealed that significantly highest grain yield (37.21 q ha-1, protein content (8.82%, N uptake (84.80 kg ha-1, P uptake (12.04 kg ha-1, No. of tillers/plant (2.5, No. of fingers/ear head (13 were recorded in inorganic treated plot when compared with organic treated plot (35.08 q ha-1 of grain yield, 8.61% of protein content,75.29 kg ha-1 of N uptake, 11.58 kg ha-1 of P uptake, 2.2 tillers/plant, 11 fingers/earhead. Organic carbon content in soil was increased in organic plot (0.02% only when compared with intial value. In both the treatments available N was reduced and available K was increased when compared with initial available N and K.

  5. Online Credit Card Transaction Using Finger Print Recognition

    S.Sivasubramanian

    2010-10-01

    Full Text Available Internet shopping, a strong alternative to traditional “go, see, touch and buy” shopping, has been one of the mostly used facilities of the Internet. Security in online payment systems has been a wide research area since the early days of the Internet and several approaches have been devised by various Organizations. But, none of the system overcome the weakness in those system. Several online shopping systems serve internet users all around the world and enable people to get the products they need with a small effort. This paper proposes a new solution that combines finger print recognition with online credit card transactions. Here the proposed system provides more security then existing system with finger print recognitionbecause of finger print is unique. Here no need to remember the more passwords, your finger is your password.

  6. Possible Gigantic Variations on the Width of Viscoelastic Fingers

    Poire, E C; Poire, Eugenia Corvera

    2002-01-01

    We analyze the effect of frequency on the width of a single finger displacing a viscoelastic fluid. We derive a generalized Darcy's law in the frequency domain for a linear viscoelastic fluid flowing in a Hele Shaw cell. This leads to an analytic expression for the dynamic permeability that has maxima which are several orders of magnitude larger than the static permeability. We then follow an argument of de Gennes to obtain the smallest possible finger width when viscoelasticity is important. Using this, and a conservation law, we obtain a lowest bound for the width of a single finger displacing a viscoelastic fluid. Our results indicate that when a small amplitude signal of the frequency that maximizes the permeability is overimposed to a constant pressure drop, gigantic variations are obtained for the finger width.

  7. An analysis of issues in biometric finger identification

    Nanda Kumar Veerasamy

    2014-06-01

    Full Text Available A Person's identity is an essential factor in this vastly connected society. Biometric Finger has wide acceptance as a genuine method for determining an individual’s identity. Biometric Finger authentication is reliable, since physical characteristics in humans are difficult to forge, harder to change or make copies. Biometric fingerprinting is one of the most popular and legally accepted biometrics used in person identification. Finger print authentication applications include Computer Applications, Network Access, Data Protection, Transaction Security, and Web Security. E-commerce and E-governments can carry out strong authentication rules. This paper analyzes issues related to Fingerprint identification to suggest viable alternatives. Keywords: Fingerprint Identification, Optical Sensors, Ultrasound Sensors, Issues in Finger Print Identification.

  8. Dose-response patterns for vibration-induced white finger

    Griffin, M; Bovenzi, M.; Nelson, C

    2003-01-01

    Aims: To investigate alternative relations between cumulative exposures to hand-transmitted vibration (taking account of vibration magnitude, lifetime exposure duration, and frequency of vibration) and the development of white finger (Raynaud's phenomenon).

  9. Finger blood content, light transmission, and pulse oximetry errors.

    Craft, T M; Lawson, R A; Young, J D

    1992-01-01

    The changes in light emitting diode current necessary to maintain a constant level of light incident upon a photodetector were measured in 20 volunteers at the two wavelengths employed by pulse oximeters. Three states of finger blood content were assessed; exsanguinated, hyperaemic, and normal. The changes in light emitting diode current with changes in finger blood content were small and are not thought to represent a significant source of error in saturation as measured by pulse oximetry. PMID:1536406

  10. Unveiling the Biometric Potential of Finger-Based ECG Signals

    André Lourenço; Hugo Silva; Ana Fred

    2011-01-01

    The ECG signal has been shown to contain relevant information for human identification. Even though results validate the potential of these signals, data acquisition methods and apparatus explored so far compromise user acceptability, requiring the acquisition of ECG at the chest. In this paper, we propose a finger-based ECG biometric system, that uses signals collected at the fingers, through a minimally intrusive 1-lead ECG setup recurring to Ag/AgCl electrodes without gel as interface with...

  11. Viscous and Gravitational Fingering in Multiphase Compositional and Compressible Flow

    Moortgat, Joachim

    2016-01-01

    Viscous and gravitational fingering refer to flow instabilities in porous media that are triggered by adverse mobility or density ratios, respectively. These instabilities have been studied extensively in the past for 1) single-phase flow (e.g., contaminant transport in groundwater, first-contact-miscible displacement of oil by gas in hydrocarbon production), and 2) multi-phase immiscible and incompressible flow (e.g., water-alternating-gas (WAG) injection in oil reservoirs). Fingering in mul...

  12. Dynamic analysis of C/C composite finger seal

    Chen Guoding; Wang Li’na; Yu Qiangpeng; Su Hua

    2014-01-01

    A seal device as an important component of aeroengines has decisive influence on performance, reliability, and working life of aeroengines. With the development of aeroengines, demands on the performance characteristics of seal devices are made strictly. Finger seal as a novel kind of sealing device, recently attracts more and more attentions in academic circles and engineering fields at home and abroad. Research on finger seals has been extensively developed, especially on leakage and wear p...

  13. Finger avulsion injuries: A report of four cases

    Fejjal N

    2008-01-01

    Full Text Available Injury that occurs to a finger wearing a ring though rare can have grave consequences. It is a preventable injury which has a peculiar mode of trauma that is usually occupational. Injury ranges from simple contusion to degloving of soft tissues to traumatic amputation. We hereby report our experience of four cases of finger avulsion injuries due to a ring and discuss their variable clinical presentation and individualized management.

  14. Prevalence of finger sucking at preschool children in Bitola

    Domnika Rajchanovska; Beti Zafirova Ivanovska

    2014-01-01

    The aim of the study was to establish the prevalence of the habit,finger sucking at pre school children in Bitola. observational cross-sectional study conducted and 1607 children from 3 to 5 years old were included. The following methods were applied: psychological testing (Test of Chuturik), clinical pediatric examination, interview with the parents and survey Child Behavior Checklist-Achenbach, 1981. The results shows that the prevalence of the habit finger sucking at the examinees was 24...

  15. Speed-stability paradox in DNA-scanning by zinc-finger proteins

    Iwahara, Junji; Levy, Yaakov

    2013-01-01

    Extensive contact with DNA via multiple zinc fingers allows highly specific DNA-binding of zinc-finger-class transcription factors, but can also slow the target search process. Here we introduce recent insights into how zinc-finger proteins can rapidly scan DNA. Potential application of the new knowledge to the zinc-finger-based technology is also discussed.

  16. Stress Distribution in Implant Retained Finger Prosthesis: A Finite Element Study

    Amornvit, Pokpong; Rokaya, Dinesh; Keawcharoen, Konrawee; Thongpulsawasdi, Nimit

    2013-01-01

    Background: Finger amputation may result from congenital cause, trauma, infection and tumours. The finger amputation may be rehabilitated with dental implant-retained finger prosthesis. The success of implant-retained finger prosthesis is determined by the implant loading. The type of the force is a determining factor in implant loading.

  17. A comprehensive assessment of cardiovascular autonomic control using photoplethysmograms recorded from the earlobe and fingers.

    Kiselev, A R; Mironov, S A; Karavaev, A S; Kulminskiy, D D; Skazkina, V V; Borovkova, E I; Shvartz, V A; Ponomarenko, V I; Prokhorov, M D

    2016-04-01

    We compare the spectral indices of photoplethysmogram variability (PPGV) estimated using photoplethysmograms recorded from the earlobe and the middle fingers of the right and left hand and analyze their correlation with similar indices of heart rate variability (HRV) in 30 healthy subjects (26 men) aged 27 (25, 29) years (median with inter-quartile ranges) at rest and under the head-up tilt test. The following spectral indices of PPGV and HRV were compared: mean heart rate (HR), total spectral power (TP), high-frequency (HF) and low-frequency (LF) ranges of TP in percents (HF% and LF%), LF/HF ratio, and spectral coherence. We assess also the index S of synchronization between the LF oscillations in HRV and PPGV. The constancy of blood pressure (BP) and moderate increase of HR under the tilt test indicate the presence of fast processes of cardiovascular adaptation with the increase of the sympathetic activity in studied healthy subjects. The impact of respiration on the PPGV spectrum (accessed by HF%) is less than on the HRV spectrum. It is shown that the proportion of sympathetic vascular activity (accessed by LF%) is constant in the PPGV of three analyzed PPGs during the tilt test. The PPGV for the ear PPG was less vulnerable to breathing influence accessed by HF% (independently from body position) than for PPGs from fingers. We reveal the increase of index S under the tilt test indicating the activation of interaction between the heart and distal vessels. The PPGV spectra for finger PPGs from different hands are highly coherent, but differ substantially from the PPGV spectrum for the ear PPG. We conclude that joint analysis of frequency components of PPGV (for the earlobe and finger PPGs of both hands) and HRV and assessment of their synchronization provide additional information about cardiovascular autonomic control. PMID:27027461

  18. Elastic fingering in rotating Hele-Shaw flows

    Carvalho, Gabriel D.

    2014-05-21

    The centrifugally driven viscous fingering problem arises when two immiscible fluids of different densities flow in a rotating Hele-Shaw cell. In this conventional setting an interplay between capillary and centrifugal forces makes the fluid-fluid interface unstable, leading to the formation of fingered structures that compete dynamically and reach different lengths. In this context, it is known that finger competition is very sensitive to changes in the viscosity contrast between the fluids. We study a variant of such a rotating flow problem where the fluids react and produce a gellike phase at their separating boundary. This interface is assumed to be elastic, presenting a curvature-dependent bending rigidity. A perturbative weakly nonlinear approach is used to investigate how the elastic nature of the interface affects finger competition events. Our results unveil a very different dynamic scenario, in which finger length variability is not regulated by the viscosity contrast, but rather determined by two controlling quantities: a characteristic radius and a rigidity fraction parameter. By properly tuning these quantities one can describe a whole range of finger competition behaviors even if the viscosity contrast is kept unchanged. © 2014 American Physical Society.

  19. Fluidic Channels Produced by Electro Hydrodynamic Viscous Fingering

    Behler, Kristopher; Wetzel, Eric

    2010-03-01

    Viscous fingering is a term describing fingerlike extensions of liquid from a column of low viscosity liquid that has been injected into a more viscous liquid. The modification of viscous fingering, known as electro hydrodynamic viscous fingering (EHVF), utilizes large electrical potentials of 10-60 kV. The fingers see a reduction in size and increase in branching behavior due to the potential applied to the system. The resulting finely structured patterns are analogous to biological systems such as blood vessels and the lymphatic system. In this study silicone oils and water were studied in thin channel Hele-Shaw cells. The interfacial tension was optimized by altering the surfactant concentration in the silicone oils. EHVF of liquid filled packed beds consisting of beads and silicone oils showed retardation of the relaxation of the fingers after the voltage was turned off. Decreased relaxation provides a means to solidify patterns into a curable material, such as polydimethylsiloxane (PDMS). After the water is evacuated from the fingers, the cured materials then possess hollow channels that can be refilled and emptied, thus creating an artificial circulatory system.

  20. Fingering induced by a solid sphere impact to viscous fluid

    Katsuragi, H

    2014-01-01

    The number of splashed fingers generated by a solid projectile's impact onto a viscous liquid layer is experimentally studied. A steel sphere is dropped onto a viscous liquid pool. Then, a fingering instability occurs around the crater's rim, depending on the experimental conditions such as projectile's inertia and the viscosity of the target liquid. When the impact inertia is not sufficient, any fingering structure cannot be observed. Contrastively, if the impact inertia is too much, the random splashing is induced and the counting of fingers becomes difficult. The clear fingering instability is observable in between these two regimes. The number of fingers $N$ is counted by using high-speed video data. The scaling of $N$ is discussed on the basis of dimensionless numbers. By assuming Rayleigh-Taylor instability, scaling laws for $N$ can be derived using Reynolds number $Re$, Weber number $We$, and Froude number $Fr$. Particularly, the scaling $N=(\\rho_r Fr)^{1/4}We^{1/2}/3^{3/4}$ is obtained for the gravity...

  1. Fingering induced by a solid sphere impact to viscous fluid

    Katsuragi Hiroaki

    2015-01-01

    Full Text Available The number of splashed fingers generated by a solid projectile’s impact onto a viscous liquid layer is experimentally studied. A steel sphere is dropped onto a viscous liquid pool. Then, a fingering instability occurs around the crater’s rim, depending on the experimental conditions such as projectile’s inertia and the viscosity of the target liquid. When the impact inertia is not sufficient, any fingering structure cannot be observed. Contrastively, if the impact inertia is too much, the random splashing is induced and the counting of fingers becomes difficult. The clear fingering instability is observable in between these two regimes. The number of fingers N is counted by using high-speed video data. The scaling of N is discussed on the basis of dimensionless numbers. By assuming Rayleigh-Taylor instability, scaling laws for N can be derived using Reynolds number Re, Weber number We, and Froude number Fr. Particularly, the scaling N = (ρrFr1/4We1/2/33/4 is obtained for the gravity-dominant cratering regime, where ρr is the density ratio between a projectile and a target. Although the experimental data considerably scatters, the scaling law is consistent with the global trend of the data behavior. Using one of the scaling laws, planetary nano crater’s rim structure is also evaluated.

  2. Enhancement of finger motion range with compliant anthropomorphic joint design.

    Çulha, Utku; Iida, Fumiya

    2016-04-01

    Robotic researchers have been greatly inspired by the human hand in the search to design and build adaptive robotic hands. Especially, joints have received a lot of attention upon their role in maintaining the passive compliance that gives the fingers flexibility and extendible motion ranges. Passive compliance, which is the tendency to be employed in motion under the influence of an external force, is the result of the stiffness and the geometrical constraints of the joints that define the direction of the motion. Based on its building elements, human finger joints have multi-directional passive compliance which means that they can move in multiple axis of motion under external force. However, due to their complex anatomy, only simplified biomechanical designs based on physiological analysis are preferred in present day robotics. To imitate the human joints, these designs either use fixed degree of freedom mechanisms which substantially limit the motion axes of compliance, or soft materials that can deform in many directions but hinder the fingers' force exertion capacities. In order to find a solution that lies between these two design approaches, we are using anatomically correct finger bones, elastic ligaments and antagonistic tendons to build anthropomorphic joints with multi-directional passive compliance and strong force exertion capabilities. We use interactions between an index finger and a thumb to show that our joints allow the extension of the range of motion of the fingers up to 245% and gripping size to 63% which can be beneficial for mechanical adaptation in gripping larger objects. PMID:26891473

  3. Biomechanical Analysis of Force Distribution in Human Finger Extensor Mechanisms

    Dan Hu

    2014-01-01

    Full Text Available The complexities of the function and structure of human fingers have long been recognised. The in vivo forces in the human finger tendon network during different activities are critical information for clinical diagnosis, surgical treatment, prosthetic finger design, and biomimetic hand development. In this study, we propose a novel method for in vivo force estimation for the finger tendon network by combining a three-dimensional motion analysis technique and a novel biomechanical tendon network model. The extensor mechanism of a human index finger is represented by an interconnected tendinous network moving around the phalanx’s dorsum. A novel analytical approach based on the “Principle of Minimum Total Potential Energy” is used to calculate the forces and deformations throughout the tendon network of the extensor mechanism when subjected to an external load and with the finger posture defined by measurement data. The predicted deformations and forces in the tendon network are in broad agreement with the results obtained by previous experimental in vitro studies. The proposed methodology provides a promising tool for investigating the biomechanical function of complex interconnected tendon networks in vivo.

  4. Integrating optical finger motion tracking with surface touch events

    Jennifer eMacRitchie

    2015-06-01

    Full Text Available This paper presents a method of integrating two contrasting sensor systems for studying human interaction with a mechanical system, using piano performance as the case study. Piano technique requires both precise small-scale motion of fingers on the key surfaces and planned large-scale movement of the hands and arms. Where studies of performance often focus on one of these scales in isolation, this paper investigates the relationship between them. Two sensor systems were installed on an acoustic grand piano: a monocular high-speed camera tracking the position of painted markers on the hands, and capacitive touch sensors attach to the key surfaces which measure the location of finger-key contacts. This paper highlights a method of fusing the data from these systems, including temporal and spatial alignment, segmentation into notes and automatic fingering annotation. Three case studies demonstrate the utility of the multi-sensor data: analysis of finger flexion or extension based on touch and camera marker location, timing analysis of finger-key contact preceding and following key presses, and characterisation of individual finger movements in the transitions between successive key presses. Piano performance is the focus of this paper, but the sensor method could equally apply to other fine motor control scenarios, with applications to human-computer interaction.

  5. Automated FingerPrint Background removal: FPB

    Morgante Michele

    2009-04-01

    Full Text Available Abstract Background The construction of a whole-genome physical map has been an essential component of numerous genome projects initiated since the inception of the Human Genome Project. Its usefulness has been proved for whole-genome shotgun projects as a post-assembly validation and recently it has also been used in the assembly step to constrain on BACs positions. Fingerprinting is usually the method of choice for construction of physical maps. A clone fingerprint is composed of true peaks representing real fragments and background peaks, mainly composed of E. coli genomic DNA, partial digestions, star activity by-products, and machine background. High-throughput fingerprinting leads to the production of thousands of BAC clone fingerprints per day. That is why background peaks removal has become an important issue and needs to be automatized, especially in capillary electrophoresis based fingerprints. Results At the moment, the only tools available for such a task are GenoProfiler and its descendant FPMiner. The large variation in the quality of fingerprints that is usually present in large fingerprinting projects represents a major difficulty in the correct removal of background peaks that has only been partially addressed by the methods so far adopted that all require a long manual optimization of parameters. Thus, we implemented a new data-independent tool, FPB (FingerPrint Background removal, suitable for large scale projects as well as mapping of few clones. Conclusion FPB is freely available at http://www.appliedgenomics.org/tools.php. FPB was used to remove the background from all fingerprints of three grapevine physical map projects. The first project consists of about 50,000 fingerprints, the second one consists of about 70,000 fingerprints, and the third one consists of about 45,000 fingerprints. In all cases a successful assembly was built.

  6. Evaluation of finger millet incorporated noodles for nutritive value and glycemic index

    Shukla, Kamini; Srivastava, Sarita

    2011-01-01

    The present study was undertaken to develop finger millet incorporated noodles for diabetic patients. Finger millet variety VL-149 was taken. The finger millet flour and refined wheat flour (RWF) were evaluated for nutrient composition. The finger millet flour (FMF) was blended in various proportions (30 to 50%) in refined wheat flour and used for the preparation of noodles. Control consisted of RWF noodles. Sensory quality and nutrient composition of finger millet noodles was evaluated. The ...

  7. Analysis of Coordinated Motions of Humanoid Robot Fingers Using Interphalangeal Joint Coordination

    Byoung-Ho Kim

    2014-01-01

    In this study, we analyse the coordinated motions of humanoid robot fingers using an interphalangeal joint coordination. For this purpose, four humanoid robot fingers with different sizes have been considered. A biomimetic interphalangeal joint coordination (IJC) formulation based on the grasp configuration of human fingers has been presented for humanoid robot fingers. The usefulness of the specified IJC formulation for human-like finger motion has been verified through comparative demonstra...

  8. Thermal stability improvement of a multiple finger power SiGe heterojunction bipolar transistor under different power dissipations using non-uniform finger spacing

    Chen Liang; Zhang Wan-Rong; Jin Dong-Yue; Shen Pei; Xie Hong-Yun; Ding Chun-Bao; Xiaa Ying; Sun Bo-Tao; Wang Ren-Qing

    2011-01-01

    method of non-uniform finger spacing is proposed to enhance thermal stability of a multiple finger power SiGe hererojunction bipolar transistor under different power dissipations. Temperature distribution on the emitter fingers of a multi-finger SiGe heterojunction bipolar transistor is studied using a numerical electro-thermal model. The results show that the SiGe heterojunction bipolar transistor with non-uniform finger spacing has a small temperature difference between fingers compared with a traditional uniform finger spacing heterojunction bipolar transistor at the same power dissipation. What is most important is that the ability to improve temperature non-uniformity is not weakened as power dissipation increases. So the method of non-uniform finger spacing is very effective in enhancing the thermal stability and the power handing capability of power device. Experimental results verify our conclusious.

  9. Thermal stability improvement of a multiple finger power SiGe heterojunction bipolar transistor under different power dissipations using non-uniform finger spacing

    A method of non-uniform finger spacing is proposed to enhance thermal stability of a multiple finger power SiGe heterojunction bipolar transistor under different power dissipations. Temperature distribution on the emitter fingers of a multi-finger SiGe heterojunction bipolar transistor is studied using a numerical electro-thermal model. The results show that the SiGe heterojunction bipolar transistor with non-uniform finger spacing has a small temperature difference between fingers compared with a traditional uniform finger spacing heterojunction bipolar transistor at the same power dissipation. What is most important is that the ability to improve temperature non-uniformity is not weakened as power dissipation increases. So the method of non-uniform finger spacing is very effective in enhancing the thermal stability and the power handing capability of power device. Experimental results verify our conclusions. (interdisciplinary physics and related areas of science and technology)

  10. 指背筋膜瓣或筋膜蒂岛状皮瓣的临床应用%Clinical application of the finger dorsum fascia pedicle flap or fascia flap

    张全荣; 芮永军; 薛明宇; 陈政; 钱俊; 张志海; 吴权; 魏苏明; 杨凯

    2013-01-01

    Objective To explore the clinical effect that the finger dorsum fascia pedicle flap or fascia flap for repairing Finger skin defects in 8 cases. Methods 3 fingers in 3 cases with finger bone reveal were repaired with the dorsum fascia flap and skin graft. 11 fingers in 5 cases with finger bone reveal were repaired with the dorsum fascia pedicle flap. Results All 14 flaps survived, the bone reveal were repaired excellently. The flaps obtained good texture and flexibility. Fingers extended function was reconstructeal. Conclusion The finger dorsum fascia pedicle flap or fascia flap is a simple and reliable method to repair defects of fingers.%目的 报道8例14指应用指背筋膜瓣或筋膜蒂岛状皮瓣修复手指皮肤缺损的临床治疗效果.方法 采用指背筋膜瓣方法修复3例3指,指背筋膜蒂岛状皮瓣移植5例11指,皮瓣面积:2.0 cm×2.0 cm~4.0 cm×3.0 cm.结果 术后皮瓣全部成活,皮瓣质地及外形好,患指伸指功能得到重建,功能恢复满意,供区功能基本无影响.结论 指背筋膜瓣或筋膜蒂岛状皮瓣是修复手指指背皮肤缺损的较好方法.

  11. Three finger palpation technique of vas deferens for keyhole vasectomy in spotted (Axis axis and sambar deer (Cervus unicolor

    B. J. William

    2014-09-01

    Full Text Available Aim: Vasectomy is performed in deer for population control, maintain pedigreed animals and prevent inbreeding. Conventional procedure of vasectomy required a long-term anesthesia and longer duration of hospitalization, which often result in stress, morbidity and mortality. A study was conducted to capture, neuter and release the deer with minimal hospitalization and stress by adopting three finger palpation technique of vas deferens and performing vasectomy through a key-hole incision. Materials and Methods: The study was conducted on three spotted male deer and three sambar male deer, which were immobilized with a mixture of xylazine at the dose of 1.00 mg/kg and ketamine at the dose of 5.00 mg/kg. The vas deferens could be palpated as a piece of cooked spaghetti at the neck of the scrotum on the anterior aspect by three finger palpation technique and was able to fix the vas deferens between the thumb and middle finger. Through a key-hole incision of <5 mm length, the vas deferens was exteriorized and resected using electrocautery and the skin incision was sealed with methyl methacrylate. The deer were released on the same day, and no post-operative complication was noticed. Conclusion: The study revealed that three finger palpation technique of vas deferens provided guidance for easy access to vas deferens for vasectomy in deer with less hospitalization, and the deer could be released on the same day.

  12. Ring finger protein 43 expression is associated with genetic alteration status and poor prognosis among patients with intrahepatic cholangiocarcinoma.

    Talabnin, Chutima; Janthavon, Patcharee; Thongsom, Sunisa; Suginta, Wipa; Talabnin, Krajang; Wongkham, Sopit

    2016-06-01

    Ring finger E3 ligases have roles in processes central to maintenance of genomic integrity and cellular homeostasis. Many ring finger E3 ligases are implicated in malignancy. Ring finger protein 43 (RNF43) is a ring finger E3 ligase that negatively regulates the Wnt/β-catenin signaling pathway. RNF43 is frequently mutated in several types of malignancy, including intrahepatic cholangiocarcinoma (ICC). The significance of its expression in ICC has not, however, been reported. We determined RNF43 expression and identified RNF43 polymorphisms in ICC tissues. We also investigated the correlation between RNF43 expression and RNF43 mutation status, RNF43 polymorphisms, clinicopathological features, and prognosis of ICC patients. RNF43 reduced expression in ICC, and the reduction of RNF43 messenger RNA expression was significantly correlated with the presence of rs2257205 and RNF43 somatic mutations, confirming that all RNF43 somatic mutations in ICC are inactivating. Overall survival was worst in patients with down-regulation of RNF43. Univariate and multivariate analyses revealed that RNF43 expression was an independent prognostic factor. There was no statistically significant association between RNF43 messenger RNA and protein expression nor any clinicopathological features or RNF43 polymorphisms. The results imply that RNF43 is down-regulated in ICC and may play a crucial role during development of ICC. PMID:26980022

  13. Magic Ring: A Finger-Worn Device for Multiple Appliances Control Using Static Finger Gestures

    Tongjun Huang

    2012-05-01

    Full Text Available An ultimate goal for Ubiquitous Computing is to enable people to interact with the surrounding electrical devices using their habitual body gestures as they communicate with each other. The feasibility of such an idea is demonstrated through a wearable gestural device named Magic Ring (MR, which is an original compact wireless sensing mote in a ring shape that can recognize various finger gestures. A scenario of wireless multiple appliances control is selected as a case study to evaluate the usability of such a gestural interface. Experiments comparing the MR and a Remote Controller (RC were performed to evaluate the usability. From the results, only with 10 minutes practice, the proposed paradigm of gestural-based control can achieve a performance of completing about six tasks per minute, which is in the same level of the RC-based method.

  14. Evaluation of electron beam irradiation for disinfection of turmeric fingers

    Turmeric finger as one of the most popular spices has been widely used for food manufacturing. However, it has also been a major cause of bacterial infestation of food materials especially in curry, ham and sausage manufacturing. In this study decontamination of bacteria in turmeric finger by electron beam irradiation was evaluated by comparing with several other decontamination methods: i.e., boiling, microwave irradiation, treatment by twin screw extruder and gamma-ray irradiation. By estimation of colony counting on nutrient agar plate, turmeric finger without any treatment gave total viable cell at 108/g. Turmeric finger which was irradiated by electron beam at 10kGy dose dramatically reduced thermotolerant cell population below self restriction level (<1000/g), which has been required by food hygiene law. The same level of sterilization effect was obtained only by gamma-ray irradiation at 10kGy and 20kGy. On the other hand, although treatment through twin screw extruder slightly reduced bacterial numbers, neither boiling nor microwave irradiation gave sufficient decontamination effect on turmeric fingers

  15. Evaluation of electron beam irradiation for disinfection of turmeric fingers

    Turmeric finger as one of the most popular spices has been widely used for food manufacturing. However, it has also been a major cause of bacterial infestation of food materials especially in curry, ham and sausage manufacturing. In this study decontamination of bacteria in turmeric finger by electron beam irradiation was evaluated by comparing with several other decontamination methods: i.e., boiling, microwave irradiation, treatment by twin screw extruder and gamma-ray irradiation. By estimation of colony counting on nutrient agar plate, turmeric finger without any treatment gave total viable cell at 108/g. Turmeric finger which was irradiated by electron beam at 10 kGy dose dramatically reduced thermotolerant cell population below self restriction level (<1000/g), which has been required by food hygiene law. The same level of sterilization effect was obtained only by gamma-ray irradiation at 10 kGy and 20 kGy. On the other hand, although treatment through twin screw extruder slightly reduced bacterial numbers, neither boiling nor microwave irradiation gave sufficient decontamination effect on turmeric fingers. (author)

  16. The biometric recognition on contactless multi-spectrum finger images

    Kang, Wenxiong; Chen, Xiaopeng; Wu, Qiuxia

    2015-01-01

    This paper presents a novel multimodal biometric system based on contactless multi-spectrum finger images, which aims to deal with the limitations of unimodal biometrics. The chief merits of the system are the richness of the permissible texture and the ease of data access. We constructed a multi-spectrum instrument to simultaneously acquire three different types of biometrics from a finger: contactless fingerprint, finger vein, and knuckleprint. On the basis of the samples with these characteristics, a moderate database was built for the evaluation of our system. Considering the real-time requirements and the respective characteristics of the three biometrics, the block local binary patterns algorithm was used to extract features and match for the fingerprints and finger veins, while the Oriented FAST and Rotated BRIEF algorithm was applied for knuckleprints. Finally, score-level fusion was performed on the matching results from the aforementioned three types of biometrics. The experiments showed that our proposed multimodal biometric recognition system achieves an equal error rate of 0.109%, which is 88.9%, 94.6%, and 89.7% lower than the individual fingerprint, knuckleprint, and finger vein recognitions, respectively. Nevertheless, our proposed system also satisfies the real-time requirements of the applications.

  17. Evaluation of electron beam irradiation for disinfection of turmeric fingers

    Yasumoto, Kyoden; Fujino, Masayuki; Supriyadi (Kyoto Univ., Uji (Japan). Research Inst. for Food Science); Suzuki, Tetsuya; Hayashi, Toru

    1991-08-01

    Turmeric finger as one of the most popular spices has been widely used for food manufacturing. However, it has also been a major cause of bacterial infestation of food materials especially in curry, ham and sausage manufacturing. In this study decontamination of bacteria in turmeric finger by electron beam irradiation was evaluated by comparing with several other decontamination methods: i.e., boiling, microwave irradiation, treatment by twin screw extruder and gamma-ray irradiation. By estimation of colony counting on nutrient agar plate, turmeric finger without any treatment gave total viable cell at 10{sup 8}/g. Turmeric finger which was irradiated by electron beam at 10 kGy dose dramatically reduced thermotolerant cell population below self restriction level (<1000/g), which has been required by food hygiene law. The same level of sterilization effect was obtained only by gamma-ray irradiation at 10 kGy and 20 kGy. On the other hand, although treatment through twin screw extruder slightly reduced bacterial numbers, neither boiling nor microwave irradiation gave sufficient decontamination effect on turmeric fingers. (author).

  18. Zinc Finger Nuclease-Mediated Gene Targeting in Plants

    Zinc finger nucleases were used to facilitate homology driven repair and site-specific transgene integration in transgenic tobacco cell cultures. A target DNA sequence containing a non-functional, partial 3' PAT gene sequence flanked by zinc finger binding sites was stably integrated into BY2 suspension cultures using Agrobacterium-mediated transformation. A transgenic event containing a single integrated copy of the target sequence was used for gene targeting through co-transformation with two different Agrobacterium strains containing: i) donor DNA sequences comprising the 5' partial DNA fragment necessary to correct the non-functional PAT gene flanked by sequences homologous to the pre-integrated target DNA and ii) DNA that encoded a zinc finger nuclease that specifically recognized binding sites within the pre-integrated target. Two gene targeting strategies differing with respect to the distance between the zinc finger binding site and the homologous sequences were used. Gene targeting was demonstrated for both strategies as evidenced by the re-constitution of a functional PAT gene and was confirmed via molecular and biochemical analyses. Sequencing of recombined DNA confirmed that PAT gene reconstitution resulted from homology-driven repair at the zinc finger nuclease cleavage site. However, imperfect recombination resulting from non-homologous processes was also observed. (author)

  19. Hybrid-Actuated Finger Prosthesis with Tactile Sensing

    Cheng Yee Low

    2013-10-01

    Full Text Available Finger prostheses are devices developed to emulate the functionality of natural human fingers. On top of their aesthetic appearance in terms of shape, size and colour, such biomimetic devices require a high level of dexterity. They must be capable of gripping an object, and even manipulating it in the hand. This paper presents a biomimetic robotic finger actuated by a hybrid mechanism and integrated with a tactile sensor. The hybrid actuation mechanism comprises a DC micromotor and a Shape Memory Alloy (SMA wire. A customized test rig has been developed to measure the force and stroke produced by the SMA wire. In parallel with the actuator development, experimental investigations have been conducted on Quantum Tunnelling Composite (QTC and Pressure Conductive Rubber (PCR towards the development of a tactile sensor for the finger. The viability of using these materials for tactile sensing has been determined. Such a hybrid actuation approach aided with tactile sensing capability enables a finger design as an integral part of a prosthetic hand for applications up to the transradial amputation level.

  20. An unusual case of finger clubbing

    Akhavani, Mohammed A. [Department of Plastic and Reconstructive Surgery, St. Georges Hospital, Blackshaw Road, Tooting, London SW17 0QT (United Kingdom)]. E-mail: mo@doctors.org.uk; Sojitra, Nilesh M. [Department of Plastic and Reconstructive Surgery, St. Georges Hospital, Blackshaw Road, Tooting, London SW17 0QT (United Kingdom); Gateley, David R. [Department of Plastic and Reconstructive Surgery, St. Georges Hospital, Blackshaw Road, Tooting, London SW17 0QT (United Kingdom)

    2005-11-01

    A 33-yr-old man presented with a short history of a rapidly expanding hard mass on the left middle fingertip that clinically appeared to be an enchondroma. This was excised and histopathology revealed an epidermal inclusion cyst.

  1. An unusual case of finger clubbing

    A 33-yr-old man presented with a short history of a rapidly expanding hard mass on the left middle fingertip that clinically appeared to be an enchondroma. This was excised and histopathology revealed an epidermal inclusion cyst

  2. Prediction of contact forces of underactuated finger by adaptive neuro fuzzy approach

    Petković, Dalibor; Shamshirband, Shahaboddin; Abbasi, Almas; Kiani, Kourosh; Al-Shammari, Eiman Tamah

    2015-12-01

    To obtain adaptive finger passive underactuation can be used. Underactuation principle can be used to adapt shapes of the fingers for grasping objects. The fingers with underactuation do not require control algorithm. In this study a kinetostatic model of the underactuated finger mechanism was analyzed. The underactuation is achieved by adding the compliance in every finger joint. Since the contact forces of the finger depend on contact position of the finger and object, it is suitable to make a prediction model for the contact forces in function of contact positions of the finger and grasping objects. In this study prediction of the contact forces was established by a soft computing approach. Adaptive neuro-fuzzy inference system (ANFIS) was applied as the soft computing method to perform the prediction of the finger contact forces.

  3. Initial results of finger imaging using Photoacoustic Computed Tomography

    van Es, Peter; Moens, Hein J Bernelot; Steenbergen, Wiendelt; Manohar, Srirang

    2014-01-01

    We present a photoacoustic computed tomography investigation on a healthy human finger, to image blood vessels with a focus on vascularity across the interphalangeal joints. The cross-sectional images were acquired using an imager specifically developed for this purpose. The images show rich detail of the digital blood vessels with diameters between 100 $\\mu$m and 1.5 mm in various orientations and at various depths. Different vascular layers in the skin including the subpapillary plexus could also be visualized. Acoustic reflections on the finger bone of photoacoustic signals from skin were visible in sequential slice images along the finger except at the location of the joint gaps. Not unexpectedly, the healthy synovial membrane at the joint gaps was not detected due to its small size and normal vascularization. Future research will concentrate on studying digits afflicted with rheumatoid arthritis to detect the inflamed synovium with its heightened vascularization, whose characteristics are potential marke...

  4. High-Speed, High-Temperature Finger Seal Test Results

    Proctor, Margaret P.; Kumar, Arun; Delgado, Irebert R.

    2002-01-01

    Finger seals have significantly lower leakage rates than conventional labyrinth seals used in gas turbine engines and are expected to decrease specific fuel consumption by over 1 percent and to decrease direct operating cost by over 0.5 percent. Their compliant design accommodates shaft growth and motion due to thermal and dynamic loads with minimal wear. The cost to fabricate these finger seals is estimated to be about half the cost to fabricate brush seals. A finger seal has been tested in NASA's High Temperature, High Speed Turbine Seal Test Rig at operating conditions up to 1200 F, 1200 ft/s, and 75 psid. Static, performance and endurance test results are presented. While seal leakage and wear performance are acceptable, further design improvements are needed to reduce the seal power loss.

  5. Reference values for the nickel concentration in human finger nails

    Gammelgaard, Bente; Peters, K; Menné, T

    1991-01-01

    A reference value for the nickel concentration in finger nails from people who are not occupationally exposed to nickel was determined on the basis of nail samples from 95 healthy individuals. The mean +/- standard deviation was 1.19 +/- 1.61 mg/kg and the median was 0.49 mg/kg (range 0.042-7.50 mg....../kg). The 95% confidence interval of the population mean was 0.51-1.26 mg/kg and the 95% confidence interval of the population median was 0.39-0.74 mg/kg. The random sample consisted of 59 women and 36 men. No significant difference between the nickel levels in finger nails from men and women could...... be demonstrated. The age of the subjects varied from 16 to 66 years. There was no correlation between age and nickel concentration in finger nails....

  6. Trigger finger presenting secondary to leiomyoma: a case report

    Harb Ziad

    2009-05-01

    Full Text Available Abstract Introduction We present a previously undescribed entity: trigger finger secondary to a leiomyoma. This is the first time such a case has been reported and highlights the fact that common conditions can sometimes present secondary to rare diseases. Case presentation A 39-year-old Caucasian man presented with a fairly typical presentation of trigger finger. During surgical treatment, the lesion was excised and sent for histology, which showed tissue consistent with a leiomyoma. The patient made an uneventful recovery. Conclusion Trigger finger is a common condition that is usually easily diagnosed and managed. However, it is important to appreciate that uncommon conditions, such as leiomyoma, can present with what is sometimes considered trivial disease, and one should always consider the differential diagnoses even when faced with relatively benign conditions.

  7. Analysis of Coordinated Motions of Humanoid Robot Fingers Using Interphalangeal Joint Coordination

    Byoung-Ho Kim

    2014-04-01

    Full Text Available In this study, we analyse the coordinated motions of humanoid robot fingers using an interphalangeal joint coordination. For this purpose, four humanoid robot fingers with different sizes have been considered. A biomimetic interphalangeal joint coordination (IJC formulation based on the grasp configuration of human fingers has been presented for humanoid robot fingers. The usefulness of the specified IJC formulation for human-like finger motion has been verified through comparative demonstrations. As a result, a proper coordination of humanoid robot fingertips can be achieved by applying our IJC formulation. Also the IJC formulation can be used to design of humanoid robot fingers.

  8. Continuous non-invasive finger blood pressure monitoring in children.

    Tanaka, H; Thulesius, O; Yamaguchi, H; Mino, M; Konishi, K

    1994-06-01

    We evaluated the performance of continuous non-invasive finger arterial pressure measurement using the volume-clamp technique (Finapres). This study was designed to compare finger arterial pressure with brachial blood pressure estimated by the auscultatory method in 217 children (90 boys and 127 girls) aged 4-16 years and in 38 adults (aged 18-45 years). Finger and brachial artery pressure readings were obtained consecutively from the ipsilateral side in the supine position. Finger arterial pressure waveforms were recorded in all children except 4 with small and thin fingers. There was good agreement for systolic pressure with only a slight underestimation of 1.9 mmHg and 5.1 mmHg lower for diastolic pressure. This difference most probably reflects inaccuracy of the auscultatory cuff method rather than an error in the Finapres. There was large inter-individual variability in Finapres recordings which might be due to differences in vasomotor tone, as demonstrated by systolic amplification in 5 patients with anorexia. However, Finapres showed a small within-subject variability (3.8 mmHg for systolic and 4.1 mmHg for diastolic pressure) determined in 5 patients during phenylephrine infusion, and as good reproducibility as the auscultatory method. These results suggest that finger arterial pressure measurement in children older than 6 years of age has similar accuracy as that in adults, and that this method is useful for clinical applications in children, especially for the non-invasive evaluation of autonomic control and cardiovascular reflexes involving transient and rapid blood pressure changes. PMID:7919764

  9. Nutritional, technological, and medical approach of finger millet (Eleusine coracana)

    Amir Gull; Gulzar Ahmad Nayik; Kamlesh Prasad; Pradyuman Kumar

    2015-01-01

    Finger millet (Eleusine coracana L.) is also known as African millet and is commonly called “ragi” in India. It has excellent nutritional value and is even superior to other common cereals. It is a richest source of calcium (344 mg) and magnesium (408 mg) than other millets. Predominant fatty acids of this millet are oleic (49%), linoleic (25%), and palmitic acids (25%). Finger millet contains both water-soluble and lipo-soluble vitamins. Emerging bakery products prepared from this millet are...

  10. Real-Time Hand Gesture Recognition Using Finger Segmentation

    Zhi-hua Chen

    2014-01-01

    Full Text Available Hand gesture recognition is very significant for human-computer interaction. In this work, we present a novel real-time method for hand gesture recognition. In our framework, the hand region is extracted from the background with the background subtraction method. Then, the palm and fingers are segmented so as to detect and recognize the fingers. Finally, a rule classifier is applied to predict the labels of hand gestures. The experiments on the data set of 1300 images show that our method performs well and is highly efficient. Moreover, our method shows better performance than a state-of-art method on another data set of hand gestures.

  11. Statistical mechanics of covariant systems with multi-fingered time

    Chirco, Goffredo

    2016-01-01

    Recently, in [Class. Quantum Grav. 33 (2016) 045005], the authors proposed a new approach extending the framework of statistical mechanics to reparametrization-invariant systems with no additional gauges. In this work, the approach is generalized to systems defined by more than one Hamiltonian constraints (multi-fingered time). We show how well known features as the Ehrenfest- Tolman effect and the J\\"uttner distribution for the relativistic gas can be consistently recovered from a covariant approach in the multi-fingered framework. Eventually, the crucial role played by the interaction in the definition of a global notion of equilibrium is discussed.

  12. Trace element finger printing of emeralds by PIXE and PIGE

    The concentrations of 18 major- and minor-elements in 12 Emeralds from different mines and two synthetic ones are measured with proton induced X-ray emission (PIXE) and γ-ray emission (PIGE). The concentration and distribution of 18 elements are used to establish the characteristic finger print pattern of each Emerald. With the help of cluster analysis of SYSTAT statistical package for IBMPC, these finger prints are analysed, from which a quantitative description of the dissimilarities between Emeralds can be given

  13. Finger Vein Recognition Using Local Line Binary Pattern

    Bakhtiar Affendi Rosdi

    2011-11-01

    Full Text Available In this paper, a personal verification method using finger vein is presented. Finger vein can be considered more secured compared to other hands based biometric traits such as fingerprint and palm print because the features are inside the human body. In the proposed method, a new texture descriptor called local line binary pattern (LLBP is utilized as feature extraction technique. The neighbourhood shape in LLBP is a straight line, unlike in local binary pattern (LBP which is a square shape. Experimental results show that the proposed method using LLBP has better performance than the previous methods using LBP and local derivative pattern (LDP.

  14. [Seal finger in Denmark diagnosed by PCR-technique].

    Jansen, Louise Charlotte; Justesen, Ulrik Stenz; Roos, Signe Moeslund; Dargis, Rimtas; Jensen, Jørgen Skov; Christensen, Jens Jørgen; Kemp, Michael

    2012-02-13

    Seal finger is an unusual infection in Denmark but is seen quite often in Greenland. A 69 year-old Danish man developed severe infection after cutting his finger on a sea urchin while handling a fishing net. Treatment with beta-lactam antibiotics had no effect. Standard culture from the lesion was negative. A Mycoplasma species was detected by PCR and DNA sequencing and subsequently cultured on special media. Specifically asked about exposure to sea mammals the patient could inform that a dead seal had also been trapped in the fishing net. PMID:22331047

  15. Non-Gaussian buoyancy statistics in fingering convection

    von Hardenberg, Jost

    2010-01-01

    We examine the statistics of active scalar fluctuations in high-Rayleigh number fingering convection with high-resolution three-dimensional numerical experiments. The one-point distribution of buoyancy fluctuations is found to present significantly non-Gaussian tails. A modified theory based on an original approach by Yakhot (1989) is used to model the active scalar distributions as a function of the conditional expectation values of scalar dissipation and fluxes in the flow. Simple models for these two quantities highlight the role of blob-like coherent structures for scalar statistics in fingering convection.

  16. Non-Gaussian buoyancy statistics in fingering convection

    Hardenberg, Jost von, E-mail: j.vonhardenberg@isac.cnr.i [Institute of Atmospheric Sciences and Climate, CNR, Torino (Italy); Paparella, Francesco, E-mail: francesco.paparella@unisalento.i [Dip. di Matematica, Universita del Salento and CMCC, Lecce (Italy)

    2010-06-07

    We examine the statistics of active scalar fluctuations in high-Rayleigh number fingering convection with high-resolution three-dimensional numerical experiments. Marked non-Gaussian tails are found in the one-point distribution of buoyancy fluctuations. A modified theory based on an original approach by Yakhot (1989) is used to model the active scalar distributions as a function of the conditional expectation values of scalar dissipation and fluxes in the flow. Simple models for these two quantities highlight the role of blob-like coherent structures for scalar statistics in fingering convection.

  17. Two-Fingered Haptic Device for Robot Hand Teleoperation

    Futoshi Kobayashi

    2011-01-01

    Full Text Available A haptic feedback system is required to assist telerehabilitation with robot hand. The system should provide the reaction force measured in the robot hand to an operator. In this paper, we have developed a force feedback device that presents a reaction force to the distal segment of the operator's thumb, middle finger, and basipodite of the middle finger when the robot hand grasps an object. The device uses a shape memory alloy as an actuator, which affords a very compact, lightweight, and accurate device.

  18. Hvad fanden er der egentlig i vejen med Salad Fingers?

    Pedersen, Lykke Buhl; Fagerstrøm, Erik; Rasmussen, Ditte Wiberg; Alrø, Thore Birkkjær; Lyborg, Mie; Jensen, Thea Sjøholm; Videriksen, Caroline Sylvang

    2015-01-01

    Salad Fingers is an animated YouTube series, created by the director David Firth. There are 10 episodes in which we follow the character Salad Fingers. From the very beginning of the series, there are signs that he is struggling with some sort of mental problems. We seek to understand Salad Fingers’ perception of reality and the cause of this perception. We have divided the analysis of our projects into three parts. The first part is an analysis based on the terms denotation and connotatio...

  19. Pattern formation of frictional fingers in a gravitational potential

    Eriksen, Jon Alm; Måløy, Knut Jørgen; Flekkøy, Eirik; Sandnes, Bjørnar

    2016-01-01

    Aligned finger structures, with a characteristic width, emerges during the slow drainage of a liquid/granular mixture in a tilted Hele-Shaw cell. A transition from vertical to horizontal alignment of the finger structures is observed as the tilting angle and the granular density are varied. An analytical model is presented, demonstrating that the alignment properties is the result of the competition between fluctuating granular stresses and the hydrostatic pressure. The dynamics is reproduced in simulations. We also show how the system explains patterns made during dyke formations.

  20. PARAMETRIC SENSITIVITY STUDY OF A FUSION REACTOR DIVERTOR COOLING FINGER

    Martin, Oliver; SIMONOVSKI IGOR

    2012-01-01

    In this paper the results of coupled thermal-mechanical Finite Element (FE) analysis on the design of a fusion reactor divertor cooling finger are presented. Beside its main purpose, to remove alpha particles, helium and other impurities from the plasma stream, a divertor has to remove approximately 15% of the total thermal power of the fusion reactor. The aim of the analysis is to assess the influence of a number of physical properties of the brazing layer (BL) of the cooling finger on the o...

  1. Management of intra-articular fracture of the fingers via mini external fixator combined with limited internal fixation

    LI Wen-jun; TIAN Wen; TIAN Guang-lei; CHEN Shan-lin; ZHANG Chang-qing; XUE Yun-hao; LI Zhong-zhe; ZHU Yin

    2009-01-01

    Background Intra-articular fractures of the fingers are common problems to emergency physicians and hand surgeons.Inappropriate management of these injuries may result in chronic pain,stiffness,deformity,or post traumatic arthritis.Ideal treatment necessitates the restoration of a stable and congruent joint that will allow early mobilization.The purpose of this study was to investigate the results of intra-articular fracture of the fingers by mini external fixator combined with limited internal fixation.Methods From May 2005 to May 2007,a total of 26 patients with intra-articular fracture of the fingers were treated by mini external fixator combined with limited internal fixation.Of the 26 cases,11 involved in metacarpophalangeal joint,and 15 interphalangeal joint in proximal interphalangeal.Kirschner wire,mini wire and absorbable suture were used for limited internal fixation.All patients were followed up and patients were accomplished with total active motion(TAM)of fingers.Results All patients were reviewed by an independent observer.The mean follow up was 13 months(range 9 to 24 months).Subjective,objective and radiographic results were evaluated.X-ray films revealed fracture union and the average radiographic union time was 7 weeks with a range of 5-12 weeks and the phalange shortening or rotation in 2 cases,joint incongruity(less than 1 mm)and joint space narrowing in 3 cases respectively.Phalangeal shortening or rotation was observed in 2 cases and joint incongruity or joint space narrowing was observed in 3 cases.An artificial implant was performed on one case for traumatic arthritis 1.5 years after surgery.Based on TAM the overall good-excellent rate of joint motion function was 80.8%.Conclusion Mini external fixator combined with limited internal fixation is a reliable and effective method for treatment of intra-articular fracture of the fingers.

  2. Load-induced changes in older individual's hand-finger tremor are ameliorated with targeting.

    Kavanagh, Justin J; Cross, Troy J; Newell, Karl M; Morrison, Steven

    2014-04-15

    The purpose of this study was to investigate hand-finger tremor dynamics when a load was applied to the finger in a group of healthy older adults. Moreover, we sought to determine if projecting a representation of the subject's finger tremor on a target was capable of overcoming the effects of loading so that hand-finger interactions returned to a state that was similar to normal tremor. Eight healthy older males (67 ± 1 year) performed a postural pointing task, where tremor was assessed using lightweight accelerometers attached to the hand and finger. Tremor was then assessed when a laser pointer was attached to the finger and switched off (the load), and then with the laser pointer attached and switched on pointing at targets of 40 mm and 20mm in diameter. The main findings of this study were that 1) loading the finger resulted in a reduction in finger tremor amplitude and increased finger tremor regularity, but no change in hand tremor, 2) loading caused increased hand-finger 8-12 Hz cross wavelet coherence and phase synchrony, and 3) pointing at different targets while the finger was loaded resulted in an increase in finger tremor amplitude, and changes in inter-segmental coupling to the extent that hand-finger dynamics reflected normal unloaded conditions. Overall, these results illustrate that the damping effects of limb loading can be offset, in part, by altering the accuracy demands of the task to make the pointing action more challenging. PMID:24503237

  3. Formal Verification of Finger Print ATM Transaction through Real Time Constraint Notation RTCN

    Vivek Kumar Singh

    2011-05-01

    Full Text Available In this paper we propose the Formal Verification of existing models like in banking sector ie ATM Transaction through biometric (Finger Print with the help of Real Time Constraint Notation. Finger print recognition is most popular and commonest method of using the biometrics. In the finger print technology, the uniqueness of epidermis of fingers is utilized for identification of user. The user has to keep its finger on a sensory pad, which reads the ridges of epidermis of finger and try to match it with available data of the finger with the bank. Sequence Diagrams (SDs, Finite State Machine (FSM have proven useful for describing transaction-oriented systems, and can form a basis for creating state charts. However, Finger Print ATM system require special support for branching, state information, and composing SDs.

  4. 78 FR 68907 - Agency Information Collection (Hand and Finger Conditions Disability Benefits Questionnaire...

    2013-11-15

    ... AFFAIRS Agency Information Collection (Hand and Finger Conditions Disability Benefits Questionnaire) Under... Benefits Questionnaire)'' in any correspondence. FOR FURTHER INFORMATION CONTACT: Crystal Rennie... and Finger Conditions Disability Benefits Questionnaire)''. SUPPLEMENTARY INFORMATION: Title: Hand...

  5. Abnormalities of Rhythmic Finger-Tapping in ADHD

    J Gordon Millichap

    2003-12-01

    Full Text Available A finger-tapping test requiring rhythmic responses to frequencies from 1 to 6Hz was performed in 27 children (21 males, 6 females; aged 6 to 14 years, mean 11 years diagnosed with ADHD, and in 33 controls at the Shaare Zedeck Medical Center, Jerusalem, Israel.

  6. Zinc finger recombinases with adaptable DNA sequence specificity.

    Chris Proudfoot

    Full Text Available Site-specific recombinases have become essential tools in genetics and molecular biology for the precise excision or integration of DNA sequences. However, their utility is currently limited to circumstances where the sites recognized by the recombinase enzyme have been introduced into the DNA being manipulated, or natural 'pseudosites' are already present. Many new applications would become feasible if recombinase activity could be targeted to chosen sequences in natural genomic DNA. Here we demonstrate efficient site-specific recombination at several sequences taken from a 1.9 kilobasepair locus of biotechnological interest (in the bovine β-casein gene, mediated by zinc finger recombinases (ZFRs, chimaeric enzymes with linked zinc finger (DNA recognition and recombinase (catalytic domains. In the "Z-sites" tested here, 22 bp casein gene sequences are flanked by 9 bp motifs recognized by zinc finger domains. Asymmetric Z-sites were recombined by the concomitant action of two ZFRs with different zinc finger DNA-binding specificities, and could be recombined with a heterologous site in the presence of a third recombinase. Our results show that engineered ZFRs may be designed to promote site-specific recombination at many natural DNA sequences.

  7. Viscous and gravitational fingering in multiphase compositional and compressible flow

    Moortgat, Joachim

    2016-03-01

    Viscous and gravitational fingering refer to flow instabilities in porous media that are triggered by adverse mobility or density ratios, respectively. These instabilities have been studied extensively in the past for (1) single-phase flow (e.g., contaminant transport in groundwater, first-contact-miscible displacement of oil by gas in hydrocarbon production), and (2) multi-phase immiscible and incompressible flow (e.g., water-alternating-gas (WAG) injection in oil reservoirs). Fingering in multiphase compositional and compressible flow has received much less attention, perhaps due to its high computational complexity. However, many important subsurface processes involve multiple phases that exchange species. Examples are carbon sequestration in saline aquifers and enhanced oil recovery (EOR) by gas or WAG injection below the minimum miscibility pressure. In multiphase flow, relative permeabilities affect the mobility contrast for a given viscosity ratio. Phase behavior can also change local fluid properties, which can either enhance or mitigate viscous and gravitational instabilities. This work presents a detailed study of fingering behavior in compositional multiphase flow in two and three dimensions and considers the effects of (1) Fickian diffusion, (2) mechanical dispersion, (3) flow rates, (4) domain size and geometry, (5) formation heterogeneities, (6) gravity, and (7) relative permeabilities. Results show that fingering in compositional multiphase flow is profoundly different from miscible conditions and upscaling techniques used for the latter case are unlikely to be generalizable to the former.

  8. Finger image quality based on singular point localization

    Wang, Jinghua; Olsen, Martin A.; Busch, Christoph

    2014-01-01

    Singular points are important global features of fingerprints and singular point localization is a crucial step in biometric recognition. Moreover the presence and position of the core point in a captured fingerprint sample can reflect whether the finger is placed properly on the sensor. Therefor...

  9. Tensile Strength of Finger Joints at Elevated Temperatures

    Nielsen, Peter C.; Olesen, Frits Bolonius

    A series of test s aimed a t establishing the effect of temperature upon the tensile strength parallel-to-grain of finger jointed laminae for glulam has been conducted in the Fire Research Laboratory at Aalborg University Centre. The objective of this report is to present the background to and the...

  10. Viscous-fingering experiments with periodic boundary conditions

    Zhao, H.; Maher, J.V. (Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA (USA))

    1990-11-15

    Experimental realization of a Hele-Shaw cell with periodic boundary conditions (PBC's) is achieved by building an azimuthal cell with two coaxial cylinders separated by a small gap. The development of viscous-fingering patterns formed by a critical binary liquid mixture at very low viscosity contrast has been observed and recorded from the onset of instability to very late stages. Comparison with the experimental results measured in cells which have sidewalls shows that PBC's yield few differences of results. At the early stage there is no sidewall disturbance so the Fourier transforms show less noise in the low-wave-number modes. Because the annular cell is larger than the earlier cells, it was possible to follow the flow to a very late nonlinear stage where, instead of showing steadily lengthening and broadening fingers, the necks of the longer fingers, crowded by fattening bulbs of the tips of the less-long fingers, constrict until their width is no longer negligible in comparison to the cell gap, at which point the pattern breaks up into a rich variety of bubbles.

  11. Port-Hamiltonian modeling for soft-finger manipulation

    Ficuciello, F.; Carloni, R.; Visser, L.C.; Stramigioli, S.

    2010-01-01

    In this paper, we present a port-Hamiltonian model of a multi-fingered robotic hand, with soft-pads, while grasping and manipulating an object. The algebraic constraints of the interconnected systems are represented by a geometric object, called Dirac structure. This provides a powerful way to descr

  12. Analyses results of the EHF FW Panel with welded fingers

    Sviridenko, M.N., E-mail: sviridenko@nikiet.ru [Open Joint-Stock Company “N.A. Dollezhall Research and Development Institute of Power Engineering”, (OJSC “NIKIET”), 107140, Malaya Krasnoselskaya 2/8, Moscow (Russian Federation); Leshukov, A.Yu.; Razmerov, A.V. [Open Joint-Stock Company “N.A. Dollezhall Research and Development Institute of Power Engineering”, (OJSC “NIKIET”), 107140, Malaya Krasnoselskaya 2/8, Moscow (Russian Federation); Tomilov, S.N.; Danilov, I.V. [Open Joint-Stock Company “N.A. Dollezhall Research and Development Institute of Power Engineering”, (OJSC “NIKIET”), 107140, Malaya Krasnoselskaya 2/8, Moscow (Russian Federation); D.V. Efremov Scientific Research Institute of Electrophysical Apparatus, 196641 St. Petersburg (Russian Federation); Strebkov, Yu.S. [Open Joint-Stock Company “N.A. Dollezhall Research and Development Institute of Power Engineering”, (OJSC “NIKIET”), 107140, Malaya Krasnoselskaya 2/8, Moscow (Russian Federation); Mazul, I.V.; Labusov, A.; Gervash, A.A.; Belov, A.V.; Semichev, D. [D.V. Efremov Scientific Research Institute of Electrophysical Apparatus, 196641 St. Petersburg (Russian Federation)

    2014-10-15

    Highlights: • The design of FW panel with welded fingers has been developed. • The FW panel with welded fingers has been analyzed. • The pressure drop in FW panel coolant path do not exceed allowable one. • The mass flow rate distribution between finger pairs are on acceptable level. • Temperatures in FW components do not exceed allowable one. - Abstract: According to Procurement Arrangement (PA) Russian Federation will procure 40% of enhanced heat flux first wall (FW) panels. The signing of PA is scheduled on November 2013. In framework of PA preparation the RF specialists perform EHF FW design optimization in order to provide the ability to operation of EHF FW panel under ITER conditions. This article contains the design description of EHF FW 14 developed by RF and following analysis have been performed: • Hydraulic analysis; • Transient thermal analysis; • Structural analysis. Analyses results show that new design of FW panel with two straight welds for finger fixation on FW beam developed by RF specialists can be used as a reference design for ITER blanket EHF FW panel loaded by 5 MW/m{sup 2} peak heat flux.

  13. Radiographically ossified ganglion cyst of finger in a swimmer

    Ganglion cysts are fibrous-walled cystic lesions closely associated with joint or tendon sheaths and contain gelatinous mucinous fluid. The radiographic appearance is usually normal. Calcification or ossification in these cysts is extremely unusual. We report on an unusual appearing ganglion cyst of the little finger in a swimmer with ossification resembling myositis ossificans. (orig.)

  14. Radiographically ossified ganglion cyst of finger in a swimmer

    Tehranzadeh, J.; Anavim, A. [Department of Radiological Sciences, University of California, Orange (United States); Lin, F. [Department of Pathology, University of California, Irvine Medical Center, Orange (Canada)

    1998-12-01

    Ganglion cysts are fibrous-walled cystic lesions closely associated with joint or tendon sheaths and contain gelatinous mucinous fluid. The radiographic appearance is usually normal. Calcification or ossification in these cysts is extremely unusual. We report on an unusual appearing ganglion cyst of the little finger in a swimmer with ossification resembling myositis ossificans. (orig.) With 3 figs., 8 refs.

  15. Fabrication of a Functional Finger Prosthesis With Simple Attachment

    Pattanaik, Bikash; Pattanaik, Seema

    2012-01-01

    Finger prosthesis is more acceptable by the patient when it allows some of the movement in the prosthesis along with the restoration of a natural appearance to the lost structures of the patient. This article describes a custom-fabricated, custom-colored prostheses made from silicone elastomers with a simple attachment to make the prosthesis functional to imitate some of the movement.

  16. Gold Finger: Metal Jewellery as a Disease Modifying Antirheumatic Therapy!

    T. Hlaing

    2009-01-01

    Full Text Available Polyarticular psoriatic arthritis is a chronic, progressive and disabling auto-immune disease often affecting the small joints of the hands in a symmetrical fashion. The disease can progress rapidly causing joint swelling and damaging cartilage and bone around the joints resulting in severe deformities. We report a very unusual case of a 49-year-old woman who presented with polyarticular psoriatic arthritis affecting all proximal interphalangeal (PIP joints of both hands except the left ring finger PIP joint. On clinical examination there was no evidence of arthritis in the left ring finger PIP joint. We confirmed the paucity of joint damage in the PIP joint of the left ring finger using more modern imaging modalities such as musculoskeletal ultrasound and MRI scan of the small joints of the hands. All other PIP joints in both hands demonstrated advanced degrees of joint damage secondary to chronic psoriatic inflammatory arthritis. We postulated that wearing a gold wedding ring has helped protecting the PIP joint of the left ring finger from the damaging effect of inflammatory arthritis. The possible mechanisms by which metal jewellery (gold ring confer protection to adjacent joints was discussed.

  17. Multi-finger haptic interaction within the MIAMM project

    Michelitsch, G.; Ruf, A.; Veen, H.A.H.C. van; Erp, J.B.F. van

    2002-01-01

    In this paper we provide a brief introduction to MIAMM - a multimodal system for exploration of music databases. Among the modalities supported, haptics plays a central role. In particula1; multi-finger haptic interaction techniques for data shaping and exploration win be investigated. We explain ou

  18. Singing Greeting Card Beeper as a Finger Pulse Sensor

    Belusic, Gregor; Zupancic, Gregor

    2010-01-01

    We constructed a robust and low-priced finger pulse sensor from a singing greeting card beeper. The beeper outputs the plethysmographic signal, which is indistinguishable from that of commercial grade sensors. The sensor can be used in school for a number of experiments in human cardiovascular physiology.

  19. Finger millet (Eleucine coracana) flour as a vehicle for fortification with zinc.

    Tripathi, Bhumika; Platel, Kalpana

    2010-01-01

    Millets, being less expensive compared to cereals and the staple for the poorer sections of population, could be the choice for fortification with micronutrients such as zinc. In view of this, finger millet, widely grown and commonly consumed in southern India, was explored as a vehicle for fortification with zinc in this investigation. Finger millet flour fortified with either zinc oxide or zinc stearate so as to provide 50mg zinc per kg flour, was specifically examined for the bioaccessibility of the fortified mineral, as measured by in vitro simulated gastrointestinal digestion procedure and storage stability. Addition of the zinc salts increased the bioaccessible zinc content by 1.5-3 times that of the unfortified flour. Inclusion of EDTA along with the fortified salt significantly enhanced the bioaccessibility of zinc from the fortified flours, the increase being three-fold. Inclusion of citric acid along with the zinc salt and EDTA during fortification did not have any additional beneficial effect on zinc bioaccessiblity. Moisture and free fatty acid contents of the stored fortified flours indicated the keeping quality of the same, up to 60 days. Both zinc oxide and zinc stearate were equally effective as fortificants, when used in combination with EDTA as a co-fortificant. The preparation of either roti or dumpling from the fortified flours stored up to 60 days did not result in any significant compromise in the bioaccessible zinc content. Thus, the present study has revealed that finger millet flour can effectively be used as a vehicle for zinc fortification to derive additional amounts of bioaccessible zinc, with reasonably good storage stability, to combat zinc deficiency. PMID:20122580

  20. Finger ridge-count asymmetry and diversity in Andean Indians and interpopulation comparisons.

    Dittmar, M

    1998-03-01

    A separate analysis of ulnar and radial finger ridge-counts, obtained from 115 Aymara Indians (55 males and 60 females) of northern Chile, was performed. From these variables, directional asymmetry, fluctuating asymmetry, indices of bilateral asymmetry (square root of A2), and intraindividual diversity (s/square root of 5) were calculated for each sex. The results show that most bimanual differences for the ridge-counts are not statistically significant in the Aymara, except for radial counts in female first and second fingers (right hand means are larger), while most ulnar-radial differences are highly significant in both sexes (radial values exceed ulnar ones). Most sex differences do not reach statistical significance, although males have more ridge-counts, lower directional asymmetry, somewhat lower fluctuating asymmetry, and lower indices of asymmetry and diversity than females. As fluctuating asymmetry is not larger in males, the dermatoglyphic findings do not indicate support for the hypothesis that males are less canalized than females. In accordance with the findings of other authors, interpopulation comparisons in the indices of asymmetry and diversity show ethnic differences. Both indices tend to be low in samples of African ancestry, high in samples of European origin, and intermediate in the Aymara, while Indian groups are characterized by high asymmetry and low diversity values. Moreover, the data reveal a geographical trend in that asymmetry and diversity values tend to decrease from the northern to the southern hemisphere in populations of Europe, the Middle East, and Africa, thus indicating greater ridge-count variability and heterogeneity among fingers in northern populations. It is assumed that this gradient primarily reflects different degrees of miscegenation and heterozygosity. PMID:9545079

  1. An endophytic fungus isolated from finger millet (Eleusine coracana) produces anti-fungal natural products

    Mousa, Walaa K.; Schwan, Adrian; Davidson, Jeffrey; Strange, Philip; Liu, Huaizhi; Zhou, Ting; Auzanneau, France-Isabelle; Raizada, Manish N

    2015-01-01

    Finger millet is an ancient African cereal crop, domesticated 7000 years ago in Ethiopia, reaching India at 3000 BC. Finger millet is reported to be resistant to various fungal pathogens including Fusarium sp. We hypothesized that finger millet may host beneficial endophytes (plant-colonizing microbes) that contribute to the antifungal activity. Here we report the first isolation of endophyte(s) from finger millet. Five distinct fungal species were isolated from roots and predicted taxonomica...

  2. Multi-finger prehension: control of a redundant mechanical system.

    Latash, Mark L; Zatsiorsky, Vladimir M

    2009-01-01

    The human hand has been a fascinating object of study for researchers in both biomechanics and motor control. Studies of human prehension have contributed significantly to the progress in addressing the famous problem of motor redundancy. After a brief review of the hand mechanics, we present results of recent studies that support a general view that the apparently redundant design of the hand is not a source of computational problems but a rich apparatus that allows performing a variety of tasks in a reliable and flexible way (the principle of abundance). Multi-digit synergies have been analyzed at two levels of a hypothetical hierarchy involved in the control of prehensile actions. At the upper level, forces and moments produced by the thumb and virtual finger (an imagined finger with a mechanical action equal to the combined mechanical action of all four fingers of the hand) co-vary to stabilize the gripping action and the orientation of the hand-held object. These results support the principle of superposition suggested earlier in robotics with respect to the control of artificial grippers. At the lower level of the hierarchy, forces and moments produced by individual fingers co-vary to stabilize the magnitude and direction of the force vector and the moment of force produced by the virtual finger. Adjustments to changes in task constraints (such as, for example, friction under individual digits) may be local and synergic. The latter reflect multi-digit prehension synergies and may be analyzed with the so-called chain effects: Sequences of relatively straightforward cause-effect links directly related to mechanical constraints leading to non-trivial strong co-variation between pairs of elemental variables. Analysis of grip force adjustments during motion of hand-held objects suggests that the central nervous system adjusts to gravitational and inertial loads differently. The human hand is a gold mine for researchers interested in the control of natural human

  3. Improving Finger Coordination in Young and Elderly Persons

    Wu, Yen-Hsun; Pazin, Nemanja; Zatsiorsky, Vladimir M.; Latash, Mark L.

    2013-01-01

    We studied the effects of a single practice session of a variable task with subject specific adjustments of task difficulty (instability) on indices of multi-finger coordination in young and elderly persons. The main hypothesis was that practicing such a task would lead to contrasting changes in the amounts of two components of variance estimated across repetitive trials within the uncontrolled manifold (UCM) hypothesis: VUCM that had no effect on total force and VORT that affected total force. In addition, we also expected to see strong transfer effects to a different task. A variable task with graded instability was designed to encourage use of variable solutions during the accurate production of total force with two fingers. The subjects practiced with the index and middle fingers pressing on individual force sensors. Overall, the older subjects showed lower indices of performance and higher indices of both VUCM and VORT. After about one hour of practice, both groups showed an increase in the index of involuntary force production by non-task fingers (enslaving). Both groups improved the indices of performance. The two variance indices showed opposite effects of practice: VORT dropped with practice while VUCM increased leading to an increase in the total amount of variance in the space of commands to fingers and in the index of force-stabilizing synergy. Performance in a simpler, non-practiced task improved, but there was no transfer of the changes in the structure of variance. Specifically, both variance components, VORT and VUCM, dropped in the non-practiced task. The results show that the neural system responsible for synergies stabilizing important features of performance is highly adaptable to practice of tasks designed to encourage use of variable solutions. We view the results as highly promising for future use in populations with impaired coordination characterized by low synergy indices. PMID:23411675

  4. 78 FR 35098 - Proposed Information Collection (Hand and Finger Disability Benefits Questionnaire) Activity...

    2013-06-11

    ... AFFAIRS Proposed Information Collection (Hand and Finger Disability Benefits Questionnaire) Activity... . Please refer to ``OMB Control No. 2900-NEW (Hand or Finger Disability Benefits Questionnaire)'' in any.... Title: Hand and Finger Disability Benefits Questionnaire, VA Form 21-0960M-7. OMB Control Number:...

  5. Squamous cell carcinoma of the finger masquerading as an abscess. Case report.

    O'Sullivan, S T

    2012-02-03

    A 43-year-old man presented with an abscess on his left ring finger, which recurred despite multiple drainage procedures. Histological examination of the lesion was unhelpful; it was only on histopathological examination of the finger after ray amputation that the diagnosis of cutaneous squamous cell carcinoma was established. This case illustrates the need to consider malignancy when dealing with chronic finger infections.

  6. The conservative treatment of mallet finger with a simple splint: a case report.

    Maitra, A.; Dorani, B

    1993-01-01

    Sixty patients with mallet finger deformity were randomly treated with either a Stack or a custom-made padded aluminium alloy malleable finger splint. Both splints were equally effective in correcting the deformity but the aluminium alloy splint was able to be fitted to a wider variety of finger shapes and sizes and caused significantly fewer skin complications.

  7. Miller scaling of finger properties in sandy soils: An indirect method for estimating finger width and velocity

    Wetting front instability is gravity driven and breaks a uniform flat front into vertically moving fingers. Linear stability analysis, dimensional analysis, and experimentation have yielded formulations in two-dimensional systems. Nondimensionalizing the flow equations yields scaled forms of the conductivity and moisture characteristics containing the microscopic length scale; fluid density; fluid dynamic viscosity; and fluid surface tension. 39 refs., 5 figs., 1 tab

  8. A new family of zinc finger proteins in petunia: structure, DNA sequence recognition, and floral organ-specific expression.

    Takatsuji, H; Nakamura, N; Katsumoto, Y

    1994-07-01

    We have previously cloned a gene for a zinc finger protein (EPF1) that is expressed specifically in petals and interacts with the promoter region of the 5-enolpyruvylshikimate-3-phosphate synthase gene in petunia. In an attempt to isolate genes encoding additional factors that interact with this promoter, we cloned four novel genes encoding zinc finger proteins (EPF2-5a, EPF2-5b, EPF2-4, and EPF2-7). Sequence analyses revealed that overall similarity between the EPF1 and the EPF2 protein family, except in the zinc finger motifs and the basic amino acid cluster, was very low, suggesting that the two groups belong to different subfamilies. DNA binding specificities of EPF1, EPF2-5, and EPF2-4 were very similar, as expected from the conserved zinc finger motifs. However, EPF2-7 showed no binding to the probes tested in spite of having the conserved motifs. DNA binding studies using a series of spacing mutant probes suggested a binding mechanism in which the EPF proteins recognize spacings in target DNA. RNA gel blot analyses and histochemical analyses with a promoter and beta-glucuronidase fusion revealed that expression of the EPF2-5 gene (EPF2-5) was petal and stamen specific. Expression of the EPF2-7 gene (EPF2-7) was sepal and petal specific and localized in vascular tissues. The preferential expression in two adjacent floral organs raises the possibility that these genes are downstream transcription factors of floral homeotic genes. PMID:8069106

  9. Schlieren Imaging of Gravitational Instabilities during Miscible Viscous Fingering of Glycerol-Water Systems

    Marin, Daniela; Stewart, Simone; Bunton, Patrick; Meiburg, Eckart; de Wit, Anne

    2015-11-01

    Viscous fingering occurs when a lower viscosity fluid displaces a higher viscosity fluid causing interfacial instabilities creating finger-like patterns. In a typical flow, the less viscous fluid is injected into the higher viscous fluid that is between the plates of a Hele-Shaw cell. In most cases for transparent flows, dye is dissolved into the displacing fluid in order to observe it. This work uses Schlieren imaging of miscible fluid displacements in a horizontal Hele-Shaw Cell, which reveals new information about the three-dimensional nature of VF. A Schlieren system is composed of a parallel light beam, a lens that brings the light to a focus, a cutoff of some type, and a camera. Schlieren does not require dye, ensuring the natural flow of the fluids is undisturbed. Here the imaging system is described followed by results of miscible flows of water in to aqueous glycerol solutions. Structures attributable to three-dimensional buoyancy-driven flows are readily observed. These results are interpreted in light of recent three-dimensional calculations. Supported by National Science Foundation CBET-1335739.

  10. Schlieren imaging of viscous fingering in a horizontal Hele-Shaw cell

    Bunton, P.; Marin, D.; Stewart, S.; Meiburg, E.; De Wit, A.

    2016-02-01

    Interfaces between different fluids can be unstable with regard to hydrodynamic instabilities such as viscous fingering or buoyancy-driven convection. To study such instabilities experimentally for transparent fluids, dyes or chemical indicators are most often used to track the dynamics. While the interfacial deformation can easily be tracked by color changes, it is difficult to have access to the internal flow structure for comparison with theoretical predictions. To overcome this problem, a modification of a Schlieren technique is introduced to image 3D flows during viscously driven instabilities in a horizontal Hele-Shaw cell without using any dye or chemical indicator. The method is exquisitely sensitive, readily yielding information about 3D flows in gaps under a millimeter and allowing imaging of the flow structure internal to the fingers, rather than merely imaging the flow boundary. Following a description of the technique, visualization of dynamics for nonreactive water-glycerol and reactive displacements is presented revealing previously unobserved internal flows. These flows are tentatively interpreted in terms of known theoretical predictions.

  11. The zinc finger transcription factor 191 is required for early embryonic development and cell proliferation

    Human zinc finger protein 191 (ZNF191/ZNF24) was cloned and characterized as a SCAN family member, which shows 94% identity to its mouse homologue zinc finger protein 191 (Zfp191). ZNF191 can specifically interact with an intronic polymorphic TCAT repeat (HUMTH01) in the tyrosine hydroxylase (TH) gene. Allelic variations of HUMTH01 have been stated to have a quantitative silencing effect on TH gene expression and to correlate with quantitative and qualitative changes in the binding by ZNF191. Zfp191 is widely expressed during embryonic development and in multiple tissues and organs in adult. To investigate the functions of Zfp191 in vivo, we have used homologous recombination to generate mice that are deficient in Zfp191. Heterozygous Zfp191 +/- mice are normal and fertile. Homozygous Zfp191 -/- embryos are severely retarded in development and die at approximately 7.5 days post-fertilization. Unexpectedly, in Zfp191 -/- and Zfp191 +/- embryos, TH gene expression is not affected. Blastocyst outgrowth experiments and the RNA interference-mediated knockdown of ZNF191 in cultured cells revealed an essential role for Zfp191 in cell proliferation. In further agreement with this function, no viable Zfp191 -/- cell lines were obtained by derivation of embryonic stem (ES) cells from blastocysts of Zfp191 +/- intercrosses or by forced homogenotization of heterozygous ES cells at high concentrations of G418. These data show that Zfp191 is indispensable for early embryonic development and cell proliferation

  12. CUTANEOUS MYXOID CYST ON THE SCLEROTIC FINGER IN A PATIENT WITH DIFFUSE SYSTEMIC SCLEROSIS

    Taeko Nakamura-Wakatsuki

    2013-10-01

    Full Text Available Skin tumors occurring on the scleroderma fingers are rarely seen. Swollen fingers are hallmarks of systemic sclerosis, and mucin deposition in the lesional skin is a constant feature in systemic sclerosis. Here we describe a case of cutaneous myxoid cyst on the flexor aspect of the sclerotic fingers in a patient with severe diffuse cutaneous systemic sclerosis. Cutaneous myxoid cyst is a relatively common benign tumor; however, cases of cutaneous myxoid cysts developing on the scleroderma fingers have not been reported to date. Mucin deposition in the sclerotic skin may be a predisposing factor in the induction of myxoid cyst on the scleroderma finger in our patient.

  13. Design of a novel finger of DLR/HIT dextrous robot hand basedon mechatronic integration

    LIU Yi-wei; ZHAO Jing-dong; JIN Ming-he; LIU Hong

    2009-01-01

    With the idea of mechatronic integration, a novel finger of the dextrous robot hand has been de-signed. The finger with nice envelop has four joints with three DOFs driven by three brushless DC motors with smaller size and more torque. The use of rigid gear head, bevel gears and linkage in the transmission system makes the finger more rigid. Abundant sensors such as joint angle sensors, joint torque sensors and temperature sensors are located in the finger. Integration and modularization are achieved at most by high integration of fin-ger body, driving system, sensors and electronics.

  14. Analysis and optimal design of an underactuated finger mechanism for LARM hand

    Yao, Shuangji; Ceccarelli, Marco; Carbone, Giuseppe; Zhan, Qiang; Lu, Zhen

    2011-09-01

    This paper aims to present general design considerations and optimality criteria for underactuated mechanisms in finger designs. Design issues related to grasping task of robotic fingers are discussed. Performance characteristics are outlined as referring to several aspects of finger mechanisms. Optimality criteria of the finger performances are formulated after careful analysis. A general design algorithm is summarized and formulated as a suitable multi-objective optimization problem. A numerical case of an underactuated robot finger design for Laboratory of Robotics and Mechatronics (LARM) hand is illustrated with the aim to show the practical feasibility of the proposed concepts and computations.

  15. Fingering versus stability in the limit of zero interfacial tension

    Bischofberger, Irmgard; Nagel, Sidney R

    2014-01-01

    The invasion of one fluid into another of higher viscosity in a quasi-two dimensional geometry typically produces complex fingering patterns. Because interfacial tension suppresses short-wavelength fluctuations, its elimination by using pairs of miscible fluids would suggest an instability producing highly ramified singular structures. Previous studies focused on wavelength selection at the instability onset and overlooked the striking features appearing more globally. Here we investigate the non-linear growth that occurs after the instability has been fully established. We find a rich variety of patterns that are characterized by the viscosity ratio between the inner and the outer fluid, $\\eta_{in}$/$\\eta_{out}$, as distinct from the most-unstable wavelength, which determines the onset of the instability. As $\\eta_{in}$/$\\eta_{out}$ increases, a regime dominated by long highly-branched fractal fingers gives way to one dominated by blunt stable structures characteristic of proportionate growth. Simultaneously...

  16. Hamiltonian formulation towards minimization of viscous fluid fingering

    Batista, Carlos; Miranda, José A

    2016-01-01

    A variational approach has been recently employed to determine the ideal time-dependent injection rate Q(t) that minimizes fingering formation when a fluid is injected in a Hele-Shaw cell filled with another fluid of much greater viscosity. However, such a calculation is approximate in nature, since it has been performed by assuming a high capillary number regime. In this work, we go one step further, and utilize a Hamiltonian formulation to obtain an analytical exact solution for Q(t), now valid for arbitrary values of the capillary number. Moreover, this Hamiltonian scheme is applied to calculate the corresponding injection rate that minimizes fingering formation in a uniform three-dimensional porous media. An analysis of the improvement offered by these exact injection rate expressions in comparison with previous approximate results is also provided.

  17. Viscous and Gravitational Fingering in Multiphase Compositional and Compressible Flow

    Moortgat, Joachim

    2016-01-01

    Viscous and gravitational fingering refer to flow instabilities in porous media that are triggered by adverse mobility or density ratios, respectively. These instabilities have been studied extensively in the past for 1) single-phase flow (e.g., contaminant transport in groundwater, first-contact-miscible displacement of oil by gas in hydrocarbon production), and 2) multi-phase immiscible and incompressible flow (e.g., water-alternating-gas (WAG) injection in oil reservoirs). Fingering in multiphase compositional and compressible flow has received much less attention, perhaps due to its high computational complexity. However, many important subsurface processes involve multiple phases that exchange species. Examples are carbon sequestration in saline aquifers and enhanced oil recovery (EOR) by gas or WAG injection below the minimum miscibility pressure. In multiphase flow, relative permeabilities affect the mobility contrast for a given viscosity ratio. Phase behavior can also change local fluid properties, w...

  18. Computer-based automatic finger- and speech-tracking system.

    Breidegard, Björn

    2007-11-01

    This article presents the first technology ever for online registration and interactive and automatic analysis of finger movements during tactile reading (Braille and tactile pictures). Interactive software has been developed for registration (with two cameras and a microphone), MPEG-2 video compression and storage on disk or DVD as well as an interactive analysis program to aid human analysis. An automatic finger-tracking system has been implemented which also semiautomatically tracks the reading aloud speech on the syllable level. This set of tools opens the way for large scale studies of blind people reading Braille or tactile images. It has been tested in a pilot project involving congenitally blind subjects reading texts and pictures. PMID:18183897

  19. Novel titanium-aluminum joints for cryogenic cold finger structures

    Meehan, H. M.; Sweet, R. C.

    For optimum performance, the sensors employed in airborne detection and surveillance systems must be maintained at low temperatures. The containing wall of the expansion volume of a Stirling cycle cooler may provide the low temperature surface for mounting the sensors. IR detectors are commonly mounted on copper heat exchanger surfaces. A stainless steel member is employed to thermally isolate and structurally stabilize such surfaces. It is pointed out that the use of an aluminum-titanium cold finger results in a considerable weight reduction. The present investigation is concerned with an attempt to obtain such structures with the aid of a technique involving the casting of molten aluminum onto an appropriately dimensioned and positioned titanium member, taking into account the fact that aluminum readily wets and bonds to clean titanium surfaces. The casting is then machined to provide the form and structure desired. It is concluded that aluminum-titanium cast structures offer good potential for use as cryogenic cold finger assemblies.

  20. Development of a finger biomechanical model and its considerations.

    Fok, Kim Seng; Chou, Siaw Meng

    2010-03-01

    The development of a biomechanical model for a human finger is faced with many challenges, such as extensor mechanism complexity, statistical indeterminacy and suitability of computational processes. Motivation for this work was to develop a computer model that is able to predict the internal loading patterns of tendons and joint surfaces experienced by the human finger, while mitigating these challenges. Proposed methodology was based on a non-linear optimising mathematical technique with a criterion of boundary conditions and equality equations, maximised against unknown parameters to reduce statistical indeterminacy. Initial validation was performed via the simulation of one dynamic and two static postures case studies. Past models and experiments were used, based on published literature, to verify the proposed model's methodology and results. The feasibility of the proposed methodology was deemed satisfactory as the simulated results were concordant with in-vivo results for the extrinsic flexors. PMID:19962148

  1. A quadratic-shaped-finger comb parametric resonator

    A large-stroke (8 µm) parametric resonator excited by an in-plane ‘shaped-finger’ electrostatic comb drive is fabricated using a 15 µm thick silicon-on-insulator microelectromechanical systems (SOI-MEMS) process. A quadratic capacitance-engagement response is synthesized by engineering a custom-shaped comb finger profile. A folded-flexure suspension allows lateral motion while constraining rotational modes. The excitation of the nonlinear parametric resonance is realized by selecting an appropriate combination of the linear and cubic electrostatic stiffness coefficients through a specific varying-gap comb-finger design. The large-amplitude parametric resonance promotes high signal-to-noise ratio for potential use in sensitive chemical gravimetric sensors, strain gauges, and mode-matched gyroscope applications. (paper)

  2. A survey on Human Computer Interaction Mechanism Using Finger Tracking

    2014-01-01

    Human Computer Interaction (HCI) is a field in which developer makes a user friendly system. User can interact with a computer system without using any conventional peripheral devices. Marker is used to recognize hand movement accurately & successfully. Researchers establish the mechanism to interact with computer system using computer vision. The interaction is better than normal static keyboard and mouse. This paper represents most of innovative mechanisms of the finger tracking used to int...

  3. Finger dexterity and visual discrimination following two yoga breathing practices

    Shirley Telles; Nilkamal Singh; Acharya Balkrishna

    2012-01-01

    Background: Practicing yoga has been shown to improve motor functions and attention. Though attention is required for fine motor and discrimination tasks, the effect of yoga breathing techniques on fine motor skills and visual discrimination has not been assessed. Aim: To study the effect of yoga breathing techniques on finger dexterity and visual discrimination. Materials and Methods: The present study consisted of one hundred and forty subjects who had enrolled for stress management...

  4. Experimental Research on the Influence of Vibration on Fingers Mobility

    Radu Panaitescu-Liess

    2013-09-01

    Full Text Available In many industrial activities the human body is exposed to vibrations transmitted through the hand-arm system. A long exposure to these vibrations can cause various health problems of blood vessels, nerves, muscles, bones, joints and upper limb [1]. This paper presents some considerations about the influence of vibration on finger joints mobility. I used a MediTouch system which consists of a motion capture device (an ergonomic glove and a dedicated software.

  5. Calculated energy response of lithium fluoride finger-tip dosimeters

    Calculations have been made of the energy response of the lithium fluoride thermoluminescent dosimeters being used at A.E.E. Winfrith for the measurement of radiation doses to the finger-tips of people handling radio-active materials. It is shown that the energy response is likely to be materially affected if the sachet in which the powder is held contains elements with atomic numbers much higher than 9 (e.g. if the sachet is made from polyvinyl chloride). (author)

  6. FINGER PULSE VOLUME IN PATIENTS WITH PANIC ATTACKS

    Bharathi, P.; Sembulingam, Prema; Sembulingam, K.; Srinivasan, T.N.; Namasivayam, A

    1992-01-01

    To study the peripheral blood flow in patients with panic attacks during “Stress” conditions, nine patients with history of panic attacks were subjected to mental stress of arithmetic calculation and room-air voluntary hyperventilation. Finger Pulse Volume (FPV) was significantly altered during the period following mental activity in untreated patients when compared to controls and patients under treatment. There was also an increase in FPV in untreated patients at rest and during recovery af...

  7. Dopamine receptor regulating factor, DRRF: A zinc finger transcription factor

    Hwang, Cheol Kyu; D'Souza, Ursula M.; Eisch, Amelia J.; Yajima, Shunsuke; Lammers, Claas-Hinrich; Yang, Young; Lee, Sang-Hyeon; Kim, Yong-Man; Nestler, Eric J.; Mouradian, M. Maral

    2001-01-01

    Dopamine receptor genes are under complex transcription control, determining their unique regional distribution in the brain. We describe here a zinc finger type transcription factor, designated dopamine receptor regulating factor (DRRF), which binds to GC and GT boxes in the D1A and D2 dopamine receptor promoters and effectively displaces Sp1 and Sp3 from these sequences. Consequently, DRRF can modulate the activity of these dopamine receptor promoters. Highest DRRF mRNA levels are found in ...

  8. Fingering in a driven hele-shaw cell

    Rauseo

    2000-12-01

    A modified Hele-Shaw cell in which the plate gap can be modulated in time was constructed. Highly nonlinear fingers on the interface between air and water in the cell were observed as the plate gap was driven at a variety of frequencies, but typically near 60 Hz. Modified equations to describe the flow in a periodically driven cell were derived and the linear stability analysis of waves on a circular fluid-fluid interface was performed. PMID:11138089

  9. Finger pad friction and its role in grip and touch

    Adams, Michael J.; Johnson, Simon A.; Lefèvre, Philippe; Lévesque, Vincent; Hayward, Vincent; André, Thibaut; Thonnard, Jean-Louis

    2013-01-01

    Many aspects of both grip function and tactile perception depend on complex frictional interactions occurring in the contact zone of the finger pad, which is the subject of the current review. While it is well established that friction plays a crucial role in grip function, its exact contribution for discriminatory touch involving the sliding of a finger pad is more elusive. For texture discrimination, it is clear that vibrotaction plays an important role in the discriminatory mechanisms. Among other factors, friction impacts the nature of the vibrations generated by the relative movement of the fingertip skin against a probed object. Friction also has a major influence on the perceived tactile pleasantness of a surface. The contact mechanics of a finger pad is governed by the fingerprint ridges and the sweat that is exuded from pores located on these ridges. Counterintuitively, the coefficient of friction can increase by an order of magnitude in a period of tens of seconds when in contact with an impermeably smooth surface, such as glass. In contrast, the value will decrease for a porous surface, such as paper. The increase in friction is attributed to an occlusion mechanism and can be described by first-order kinetics. Surprisingly, the sensitivity of the coefficient of friction to the normal load and sliding velocity is comparatively of second order, yet these dependencies provide the main basis of theoretical models which, to-date, largely ignore the time evolution of the frictional dynamics. One well-known effect on taction is the possibility of inducing stick–slip if the friction decreases with increasing sliding velocity. Moreover, the initial slip of a finger pad occurs by the propagation of an annulus of failure from the perimeter of the contact zone and this phenomenon could be important in tactile perception and grip function. PMID:23256185

  10. Finger in air : touch-less interaction on smartphone

    Lu, Zhihan; Halawani, Alaa; Khan, Muhammad Sikandar Lal; ur Rehman, Shafiq; LI, HAIBO

    2013-01-01

    In this paper we present a vision based intuitive interactionmethod for smart mobile devices. It is based on markerlessfinger gesture detection which attempts to provide a ‘naturaluser interface’. There is no additional hardware necessaryfor real-time finger gesture estimation. To evaluate thestrengths and effectiveness of proposed method, we designtwo smart phone applications, namely circle menu application- provides user with graphics and smart phone’s statusinformation, and bouncing ball g...

  11. ZifBASE: a database of zinc finger proteins and associated resources

    Punetha Ankita

    2009-09-01

    Full Text Available Abstract Background Information on the occurrence of zinc finger protein motifs in genomes is crucial to the developing field of molecular genome engineering. The knowledge of their target DNA-binding sequences is vital to develop chimeric proteins for targeted genome engineering and site-specific gene correction. There is a need to develop a computational resource of zinc finger proteins (ZFP to identify the potential binding sites and its location, which reduce the time of in vivo task, and overcome the difficulties in selecting the specific type of zinc finger protein and the target site in the DNA sequence. Description ZifBASE provides an extensive collection of various natural and engineered ZFP. It uses standard names and a genetic and structural classification scheme to present data retrieved from UniProtKB, GenBank, Protein Data Bank, ModBase, Protein Model Portal and the literature. It also incorporates specialized features of ZFP including finger sequences and positions, number of fingers, physiochemical properties, classes, framework, PubMed citations with links to experimental structures (PDB, if available and modeled structures of natural zinc finger proteins. ZifBASE provides information on zinc finger proteins (both natural and engineered ones, the number of finger units in each of the zinc finger proteins (with multiple fingers, the synergy between the adjacent fingers and their positions. Additionally, it gives the individual finger sequence and their target DNA site to which it binds for better and clear understanding on the interactions of adjacent fingers. The current version of ZifBASE contains 139 entries of which 89 are engineered ZFPs, containing 3-7F totaling to 296 fingers. There are 50 natural zinc finger protein entries ranging from 2-13F, totaling to 307 fingers. It has sequences and structures from literature, Protein Data Bank, ModBase and Protein Model Portal. The interface is cross linked to other public

  12. The transition to endoreduplication in trophoblast giant cells is regulated by the mSNA zinc finger transcription factor.

    Nakayama, H; Scott, I C; Cross, J C

    1998-07-01

    Terminal cell differentiation is usually associated with cell cycle exit. In some lineages, however, cells undergo continued rounds of DNA synthesis without intervening mitoses (endoreduplication) resulting in polyploid nuclei. This is striking in rodent trophoblast giant cells which contain up to 1000N of DNA. In Drosophila, the Escargot gene has been implicated in regulating the transition from mitotic cell cycles to endocycles during development. We found that a murine homologue, mSna, was expressed in mouse trophoblast and was downregulated during giant cell differentiation. The mSNA zinc finger protein bound to E-box DNA elements and, in transfected C3H10T1/2 fibroblasts, acted as a transcriptional repressor. The maximal repressive effect was dependent on both the zinc finger DNA-binding domain and the N-terminal, seven-amino-acid SNAG domain. Misexpression experiments in Rcho-1 trophoblast cells revealed that mSna regulates the transition from replicating precursor cells to committed giant cells: overexpression blocked, whereas antisense RNA-mediated underexpression promoted trophoblast giant cell differentiation. Overexpression of mSna in precursor cells had no effect on cell cycle kinetics, but did increase cyclin A and B levels, implying actions during G2. These effects were dependent on both the zinc finger and SNAG domains. Together, these data suggest that mSNA has an ESCARGOT-like function to repress the transcription of genes that promote the transition from mitotic to endoreduplicative cell cycles in rodent trophoblast. PMID:9676199

  13. Cloning and characterization of SmZF1, a gene encoding a Schistosoma mansoni zinc finger protein

    Souza Paulo R Eleutério de

    2001-01-01

    Full Text Available The zinc finger motifs (Cys2His2 are found in several proteins playing a role in the regulation of transcripton. SmZF1, a Schistosoma mansoni gene encoding a zinc finger protein was initially isolated from an adult worm cDNA library, as a partial cDNA. The full sequence of the gene was obtained by subcloning and sequencing cDNA and genomic fragments. The collated gene sequence is 2181 nt and the complete cDNA sequence is 705 bp containing the full open reading frame of the gene. Analysis of the genome sequence revealed the presence of three introns interrupting the coding region. The open reading frame theoretically encodes a protein of 164 amino acids, with a calculated molecular mass of 18,667Da. The predicted protein contains three zinc finger motifs, usually present in transcription regulatory proteins. PCR amplification with specific primers for the gene allowed for the detection of the target in egg, cercariae, schistosomulum and adult worm cDNA libraries indicating the expression of the mRNA in these life cycle stages of S. mansoni. This pattern of expression suggests the gene plays a role in vital functions of different life cycle stages of the parasite. Future research will be directed to elucidate the functional role of SmZF1.

  14. Emotion Teaching Interface for Finger Braille Emotion Teaching System

    Yasuhiro Matsuda

    2014-01-01

    Full Text Available Finger Braille is one of the tactual communication methods utilized by deafblind individuals. Deafblind people who are skilled in Finger Braille can catch up with speech conversation and express various emotions by changing dotting strength and speed. In this paper, we designed the emotion teaching interface in order to express joy, sadness, anger and neutral for the Finger Braille emotion teaching system. We changed the previous background color (beige of the teaching interface into 17 different colors. We also designed 8 kinds of dot patterns with different horizontal width and vertical length. The experiment to select the most suitable emotion teaching interfaces for joy, sadness, anger and neutral was conducted. The results showed that the dot patterns 6 (the wide and middle length pattern or 1 (the small circle with the lime, dark orange or yellow background colors are suitable for joy; the dot patterns 7 (the narrow and long pattern or 4 (the narrow and middle length pattern with the lavender, navy or blue background colors are suitable for sadness; the dot patterns 9 (the large circle or 8 (the middle width and long pattern with the red background color are suitable for anger; the dot pattern 5 (the middle circle with the previous, honeydew, saddle brown or white background colors are suitable for neutral.

  15. Finger dexterity and visual discrimination following two yoga breathing practices

    Shirley Telles

    2012-01-01

    Full Text Available Background: Practicing yoga has been shown to improve motor functions and attention. Though attention is required for fine motor and discrimination tasks, the effect of yoga breathing techniques on fine motor skills and visual discrimination has not been assessed. Aim: To study the effect of yoga breathing techniques on finger dexterity and visual discrimination. Materials and Methods: The present study consisted of one hundred and forty subjects who had enrolled for stress management. They were randomly divided into two groups, one group practiced high frequency yoga breathing while the other group practiced breath awareness. High frequency yoga breathing (kapalabhati, breath rate 1.0 Hz and breath awareness are two yoga practices which improve attention. The immediate effect of high frequency yoga breathing and breath awareness (i were assessed on the performance on the O′Connor finger dexterity task and (ii (in a shape and size discrimination task. Results: There was a significant improvement in the finger dexterity task by 19% after kapalabhati and 9% after breath awareness (P<0.001 in both cases, repeated measures ANOVA and post-hoc analyses. There was a significant reduction (P<0.001 in error (41% after kapalabhati and 21% after breath awareness as well as time taken to complete the shape and size discrimination test (15% after kapalabhati and 15% after breath awareness; P<0.001 was also observed. Conclusion: Both kapalabahati and breath awareness can improve fine motor skills and visual discrimination, with a greater magnitude of change after kapalabhati.

  16. Phylogenetic Analysis of the Plant-specific Zinc Finger-Homeobox and Mini Zinc Finger Gene Families

    Wei Hu; Claude W.dePamphilis; Hong Ma

    2008-01-01

    Zinc finger-homaodomain proteins (ZHD) are present in many plants;however,the evolutionary history of the ZHD gene family remains largely unknown.We show here that ZHD genes are plant-specific,nearly all intronless,and related to MINI ZINC FINGER (MIF) genes that possess only the zinc finger.Phylogenetic analyses of ZHD genes from representative land plants suggest that non-seed plant ZHD genes occupy basal positions and angiosperm homologs form seven distinct clades.Several clades contain genes from two or more major angiosperm groups,including eudicots,monocots,magnoliids,and other basal angiosperms,indicating that several duplications occurred before the diversification of flowering plants.In addition,specific lineages have experienced more recent duplications.Unlike the ZHD genes,&fiFs are found only from seed plants,possibly derived from ZHDs by loss of the homeodomain before the divergence of seed plants.Moreover,the MIF genes have also undergone relatively recent gene duplications.Finally,genome duplication might have contributed substantially to the expansion of family size in angiosperms and caused a high level of functional redundancy/overlap in these genes.

  17. Stabilization of the total force in multi-finger pressing tasks studied with the ‘inverse piano’ technique

    J R Martin; Budgeon, M.K.; Zatsiorsky, V.M.; Latash, M.L.

    2011-01-01

    When one finger changes its force, other fingers of the hand can show unintended force changes in the same direction (enslaving) and in the opposite direction (error compensation). We tested a hypothesis that externally imposed changes in finger force predominantly lead to error compensation effects in other fingers thus stabilizing the total force. A novel device, the “inverse piano”, was used to impose controlled displacements to one of the fingers over different magnitudes and at different...

  18. Design of Shape Memory Alloy-Based and Tendon-Driven Actuated Fingers Towards a Hybrid Anthropomorphic Prosthetic Hand

    Erkan Kaplanoglu

    2012-01-01

    This paper presents the design of tendon‐driven actuated fingers using a shape memory alloy for a hybrid anthropomorphic prosthetic hand. The ring and little (pinky) fingers are selected for shape memory activation due to their lower degree of movement during multiple grasping configurations. The fingersʹ tendon system is based on shape memory alloy (SMA) wires that form artificial muscle pairs for the required flexion/extension of the finger joints. The finger has four degrees of freedom suc...

  19. Tracing QTLs for Leaf Blast Resistance and Agronomic Performance of Finger Millet (Eleusine coracana (L.) Gaertn.) Genotypes through Association Mapping and in silico Comparative Genomics Analyses

    Ramakrishnan, M.; Antony Ceasar, S.; Duraipandiyan, V.; Vinod, K. K.; Kalpana, Krishnan; Al-Dhabi, N. A.; Ignacimuthu, S.

    2016-01-01

    Finger millet is one of the small millets with high nutritive value. This crop is vulnerable to blast disease caused by Pyricularia grisea, which occurs annually during rainy and winter seasons. Leaf blast occurs at early crop stage and is highly damaging. Mapping of resistance genes and other quantitative trait loci (QTLs) for agronomic performance can be of great use for improving finger millet genotypes. Evaluation of one hundred and twenty-eight finger millet genotypes in natural field conditions revealed that leaf blast caused severe setback on agronomic performance for susceptible genotypes, most significant traits being plant height and root length. Plant height was reduced under disease severity while root length was increased. Among the genotypes, IE4795 showed superior response in terms of both disease resistance and better agronomic performance. A total of seven unambiguous QTLs were found to be associated with various agronomic traits including leaf blast resistance by association mapping analysis. The markers, UGEP101 and UGEP95, were strongly associated with blast resistance. UGEP98 was associated with tiller number and UGEP9 was associated with root length and seed yield. Cross species validation of markers revealed that 12 candidate genes were associated with 8 QTLs in the genomes of grass species such as rice, foxtail millet, maize, Brachypodium stacei, B. distachyon, Panicum hallii and switchgrass. Several candidate genes were found proximal to orthologous sequences of the identified QTLs such as 1,4-β-glucanase for leaf blast resistance, cytokinin dehydrogenase (CKX) for tiller production, calmodulin (CaM) binding protein for seed yield and pectin methylesterase inhibitor (PMEI) for root growth and development. Most of these QTLs and their putatively associated candidate genes are reported for first time in finger millet. On validation, these novel QTLs may be utilized in future for marker assisted breeding for the development of fungal

  20. Investigation and modeling of the avalanche effect in MOSFETs with non-uniform finger spacing

    Liu Jun; Sun Lingling; Marissa Condon

    2011-01-01

    This paper investigates the effect of a non-uniform gate-finger spacing layout structure on the avalanche breakdown performance of RF CMOS technology.Compared with a standard multi-finger device with uniform gate-finger spacing,a device with non-uniform gate-finger spacing represents an improvement of 8.5% for the drain-source breakdown voltage(BVds)and of 20% for the thermally-related drain conductance.A novel compact model is proposed to accurately predict the variation of BVds with the total area of devices,which is dependent on the different finger spacing sizes.The model is verified and validated by the excellent match between the measured and simulated avalanche breakdown characteristics for a set of uniform and non-uniform gate-finger spacing arranged nMOSFETs.

  1. Width of a ferrofluid finger: hysteresis and a double energy minimum.

    Hillier, Narelle J; Jackson, David P

    2007-03-01

    We study a ferrofluid in a horizontal Hele-Shaw geometry subjected to a vertical magnetic field. Specifically, we calculate the energy of a single ferrofluid finger using an idealized model for the finger. By minimizing this energy, we find the preferred finger width as a function of the applied field. Our model predicts a first order transition as the fluid abruptly transforms from a circular drop to a finite finger. This behavior arises because of a double energy minimum that yields two different stable configurations for the system. Interestingly, this system exhibits hysteresis as the circle-to-finger (increasing field) transition occurs at a different applied field than the finger-to-circle (decreasing field) transition. We carry out a simple experiment and observe good overall agreement with the theoretical predictions. PMID:17500798

  2. Ret Finger Protein: An E3 Ubiquitin Ligase Juxtaposed to the XY Body in Meiosis

    Isabelle Gillot

    2009-01-01

    Full Text Available During prophase I of male meiosis, the sex chromosomes form a compact structure called XY body that associates with the nuclear membrane of pachytene spermatocytes. Ret Finger Protein is a transcriptional repressor, able to interact with both nuclear matrix-associated proteins and double-stranded DNA. We report the precise and unique localization of Ret Finger Protein in pachytene spermatocytes, in which Ret Finger Protein takes place of lamin B1, between the XY body and the inner nuclear membrane. This localization of Ret Finger Protein does not seem to be associated with O-glycosylation or sumoylation. In addition, we demonstrate that Ret Finger Protein contains an E3 ubiquitin ligase activity. These observations lead to an attractive hypothesis in which Ret Finger Protein would be involved in the positioning and the attachment of XY body to the nuclear lamina of pachytene spermatocytes.

  3. Optical Myography: Detecting Finger Movements by Looking at the Forearm

    Christian eNissler

    2016-04-01

    Full Text Available One of the crucial problems found in the scientific community of assistive / rehabilitation robotics nowadays is that of automatically detecting what a disabled subject (for instance, a hand amputee wants to do, exactly when she wants to do it and strictly for the time she wants to do it. This problem, commonly called intent detection, has traditionally been tackled using surface electromyography, a technique which suffers from a number of drawbacks, including the changes in the signal induced by sweat and muscle fatigue. With the advent of realistic, physically plausible augmented- and virtual-reality environments for rehabilitation, this approach does not suffice anymore. In this paper we explore a novel method to solve the problem, that we call Optical Myography (OMG. The idea is to visually inspect the human forearm (or stump to reconstruct what fingers are moving and to what extent. In a psychophysical experiment involving ten intact subjects, we used visual fiducial markers (AprilTags and a standard web-camera to visualize the deformations of the surface of the forearm, which then were mapped to the intended finger motions. As ground truth, a visual stimulus was used, avoiding the need for finger sensors (force/position sensors, datagloves, etc.. Two machine-learning approaches, a linear and a non-linear one, were comparatively tested in settings of increasing realism. The results indicate an average error in the range of 0.05 to 0.22 (root mean square error normalized over the signal range, in line with similar results obtained with more mature techniques such as electromyography. If further successfully tested in the large, this approach could lead to vision-based intent detection of amputees, with the main application of letting such disabled persons dexterously and reliably interact in an augmented- / virtual-reality setup.

  4. Optical Myography: Detecting Finger Movements by Looking at the Forearm.

    Nissler, Christian; Mouriki, Nikoleta; Castellini, Claudio

    2016-01-01

    One of the crucial problems found in the scientific community of assistive/rehabilitation robotics nowadays is that of automatically detecting what a disabled subject (for instance, a hand amputee) wants to do, exactly when she wants to do it, and strictly for the time she wants to do it. This problem, commonly called "intent detection," has traditionally been tackled using surface electromyography, a technique which suffers from a number of drawbacks, including the changes in the signal induced by sweat and muscle fatigue. With the advent of realistic, physically plausible augmented- and virtual-reality environments for rehabilitation, this approach does not suffice anymore. In this paper, we explore a novel method to solve the problem, which we call Optical Myography (OMG). The idea is to visually inspect the human forearm (or stump) to reconstruct what fingers are moving and to what extent. In a psychophysical experiment involving ten intact subjects, we used visual fiducial markers (AprilTags) and a standard web camera to visualize the deformations of the surface of the forearm, which then were mapped to the intended finger motions. As ground truth, a visual stimulus was used, avoiding the need for finger sensors (force/position sensors, datagloves, etc.). Two machine-learning approaches, a linear and a non-linear one, were comparatively tested in settings of increasing realism. The results indicate an average error in the range of 0.05-0.22 (root mean square error normalized over the signal range), in line with similar results obtained with more mature techniques such as electromyography. If further successfully tested in the large, this approach could lead to vision-based intent detection of amputees, with the main application of letting such disabled persons dexterously and reliably interact in an augmented-/virtual-reality setup. PMID:27148039

  5. Optical Myography: Detecting Finger Movements by Looking at the Forearm

    Nissler, Christian; Mouriki, Nikoleta; Castellini, Claudio

    2016-01-01

    One of the crucial problems found in the scientific community of assistive/rehabilitation robotics nowadays is that of automatically detecting what a disabled subject (for instance, a hand amputee) wants to do, exactly when she wants to do it, and strictly for the time she wants to do it. This problem, commonly called “intent detection,” has traditionally been tackled using surface electromyography, a technique which suffers from a number of drawbacks, including the changes in the signal induced by sweat and muscle fatigue. With the advent of realistic, physically plausible augmented- and virtual-reality environments for rehabilitation, this approach does not suffice anymore. In this paper, we explore a novel method to solve the problem, which we call Optical Myography (OMG). The idea is to visually inspect the human forearm (or stump) to reconstruct what fingers are moving and to what extent. In a psychophysical experiment involving ten intact subjects, we used visual fiducial markers (AprilTags) and a standard web camera to visualize the deformations of the surface of the forearm, which then were mapped to the intended finger motions. As ground truth, a visual stimulus was used, avoiding the need for finger sensors (force/position sensors, datagloves, etc.). Two machine-learning approaches, a linear and a non-linear one, were comparatively tested in settings of increasing realism. The results indicate an average error in the range of 0.05–0.22 (root mean square error normalized over the signal range), in line with similar results obtained with more mature techniques such as electromyography. If further successfully tested in the large, this approach could lead to vision-based intent detection of amputees, with the main application of letting such disabled persons dexterously and reliably interact in an augmented-/virtual-reality setup. PMID:27148039

  6. Median Nerve Deformation and Displacement in the Carpal Tunnel during Index Finger and Thumb Motion

    van Doesburg, Margriet H. M.; Yoshii, Yuichi; Villarraga, Hector R.; Henderson, Jacqueline; Cha, Stephen s; An, Kai-Nan; Amadio, Peter C.

    2010-01-01

    The purpose of this study was to investigate the deformation and displacement of the normal median nerve in the carpal tunnel during index finger and thumb motion, using ultrasound. Thirty wrists from 15 asymptomatic volunteers were evaluated. Cross-sectional images during motion from full extension to flexion of the index finger and thumb were recorded. On the initial and final frames, the median nerve, flexor pollicis longus (FPL), and index finger flexor digitorum superficialis (FDS) tendo...

  7. Computer simulation of viscous fingering in a lifting Hele-Shaw cell with grooved plates

    Sujata Tarafdar; Soma Nag; Tapati Dutta; Suparna Sinha

    2009-10-01

    We simulate viscous fingering generated by separating two plates with a constant force, in a lifting Hele-Shaw cell. Variation in the patterns for different fluid viscosity and lifting force is studied. Viscous fingering is strongly affected by anisotropy. We report a computer simulation study of fingering patterns, where circular or square grooves are etched on to the lower plate. Results are compared with experiments.

  8. Compliant finger sensor for sensorimotor studies in MEG and MR environment

    Li, Y.; Yong, X.; Cheung, T. P. L.; Menon, C.

    2016-07-01

    Magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) are widely used for functional brain imaging. The correlations between the sensorimotor functions of the hand and brain activities have been investigated in MEG/fMRI studies. Currently, limited information can be drawn from these studies due to the limitations of existing motion sensors that are used to detect hand movements. One major challenge in designing these motion sensors is to limit the signal interference between the motion sensors and the MEG/fMRI. In this work, a novel finger motion sensor, which contains low-ferromagnetic and non-conductive materials, is introduced. The finger sensor consists of four air-filled chambers. When compressed by finger(s), the pressure change in the chambers can be detected by the electronics of the finger sensor. Our study has validated that the interference between the finger sensor and an MEG is negligible. Also, by applying a support vector machine algorithm to the data obtained from the finger sensor, at least 11 finger patterns can be discriminated. Comparing to the use of traditional electromyography (EMG) in detecting finger motion, our proposed finger motion sensor is not only MEG/fMRI compatible, it is also easy to use. As the signals acquired from the sensor have a higher SNR than that of the EMG, no complex algorithms are required to detect different finger movement patterns. Future studies can utilize this motion sensor to investigate brain activations during different finger motions and correlate the activations with the sensory and motor functions respectively.

  9. A Hybrid Model for Biometric Authentication using Finger Back Knuckle Surface based on Angular Geometric Analysis

    Usha, K.; M. Ezhilarasan

    2013-01-01

    Biometric based personal recognition is an efficient method for identifying a person. Recently, hand based biometric has become popular due to its various advantages such as high verification accuracy and high user acceptability. This paper proposes a hybrid model using an emerging hand based biometric trait known as Finger Back Knuckle Surface. This model is based on angular geometric analysis which is implemented on two different samples of Finger Back Knuckle Surface such as Finger Bend Kn...

  10. Sensory Feedback Training for Improvement of Finger Perception in Cerebral Palsy

    Tobias Blumenstein; Ana Alves-Pinto; Varvara Turova; Simon Aschmann; Ines Lützow; Renée Lampe

    2015-01-01

    Purpose. To develop and to test a feedback training system for improvement of tactile perception and coordination of fingers in children and youth with cerebral palsy. Methods. The fingers of 7 probands with cerebral palsy of different types and severity were stimulated using small vibration motors integrated in the fingers of a hand glove. The vibration motors were connected through a microcontroller to a computer and to a response 5-button keyboard. By pressing an appropriate keyboard butto...

  11. Invariantly propagating dissolution fingers in finite-width systems

    Dutka, Filip; Szymczak, Piotr

    2016-04-01

    Dissolution fingers are formed in porous medium due to positive feedback between transport of reactant and chemical reactions [1-4]. We investigate two-dimensional semi-infinite systems, with constant width W in one direction. In numerical simulations we solve the Darcy flow problem combined with advection-dispersion-reaction equation for the solute transport to track the evolving shapes of the fingers and concentration of reactant in the system. We find the stationary, invariantly propagating finger shapes for different widths of the system, flow and reaction rates. Shape of the reaction front, turns out to be controlled by two dimensionless numbers - the (width-based) Péclet number PeW = vW/Dφ0 and Damköhler number DaW = ksW/v, where k is the reaction rate, s - specific reactive surface area, v - characteristic flow rate, D - diffusion coefficient of the solute, and φ0 - initial porosity of the rock matrix. Depending on PeW and DaW stationary shapes can be divided into seperate classes, e.g. parabolic-like and needle-like structures, which can be inferred from theoretical predictions. In addition we determine velocity of propagating fingers in time and concentration of reagent in the system. Our simulations are compared with natural forms (solution pipes). P. Ortoleva, J. Chadam, E. Merino, and A. Sen, Geochemical self-organization II: the reactive-infiltration instability, Am. J. Sci, 287, 1008-1040 (1987). M. L. Hoefner, and H. S. Fogler. Pore evolution and channel formation during flow and reaction in porous media, AIChE Journal 34, 45-54 (1988). C. E. Cohen, D. Ding, M. Quintard, and B. Bazin, From pore scale to wellbore scale: impact of geometry on wormhole growth in carbonate acidization, Chemical Engineering Science 63, 3088-3099 (2008). P. Szymczak and A. J. C. Ladd, Reactive-infiltration nstabilities in rocks. Part II: Dissolution of a porous matrix, J. Fluid Mech. 738, 591-630 (2014).

  12. Traumatic Amputation of Finger From an Alligator Snapping Turtle Bite.

    Johnson, Robert D; Nielsen, Cynthia L

    2016-06-01

    Legend states that the alligator snapping turtle (Macrochelys temminckii) should be handled with extreme caution as it has jaw strength powerful enough to bite a wooden broomstick in half. Tales of bite injuries from what is the largest freshwater turtle in North America exist anecdotally, yet there are few descriptions of medical encounters for such. The risk of infection from reptilian bites to the hand in an aquatic environment warrants thorough antibiotic treatment in conjunction with hand surgery consultation. We present the first case report of a near total amputation of an index finger in an adolescent boy who had been bitten by a wild "gator snapper." PMID:27116923

  13. GANGLION CYST IN THE ROOT OF THE LEFT INDEX FINGER

    Manoj

    2014-06-01

    Full Text Available Ganglion cyst is a condition where there is herniation of synovium from the joint space to the exterior and presents as a cystic mass. The cyst can maintain the connection to the joint space. There is potential risk of injury and infection due to even a trivial trauma leading to complications like arthritis and septicemia. The ganglion cysts normally observed in major and weight bearing joints. The incidence in small joints are uncommon. The present patient presented with a cystic lesion in the root of the left index finger.

  14. Occult lung malignancy presenting with finger pain: a case report

    Embley Matthew A

    2008-12-01

    Full Text Available Abstract Introduction Lung cancer is currently one of the most common malignancies in the world. Early detection is an important prognostic factor. Unfortunately, initial symptoms may be vague and a substantial proportion of cases present with the effects of metastases. Case presentation We discuss a case of occult lung malignancy in a 61-year-old man. The only symptom at presentation was pain in the right ring finger due to metastasis from the lung primary. Conclusion This case highlights the need for vigilance when a patient presents with unusual or unexplained symptoms, especially if they have known risk factors for cancer.

  15. A Site-Based Proxy Cache

    ZHU Jing(朱晶); YANG GuangWen(杨广文); HU Min(胡敏); SHEN MeiMing(沈美明)

    2003-01-01

    In traditional proxy caches, any visited page from any Web server is cachedindependently, ignoring connections between pages. And users still have to frequently visit indexingpages just for reaching useful informative ones, which causes significant waste of caching space andunnecessary Web traffic. In order to solve the above problem, this paper introduced a site graphmodel to describe WWW and a site-based replacement strategy has been built based on it. Theconcept of "access frequency" is developed for evaluating whether a Web page is worth beingkept in caching space. On the basis of user's access history, auxiliary navigation information isprovided to help him reach target pages more quickly. Performance test results have shown thatthe proposed proxy cache system can get higher hit ratio than traditional ones and can reduceuser's access latency effectively.

  16. Evaluation of finger millet incorporated noodles for nutritive value and glycemic index.

    Shukla, Kamini; Srivastava, Sarita

    2014-03-01

    The present study was undertaken to develop finger millet incorporated noodles for diabetic patients. Finger millet variety VL-149 was taken. The finger millet flour and refined wheat flour (RWF) were evaluated for nutrient composition. The finger millet flour (FMF) was blended in various proportions (30 to 50%) in refined wheat flour and used for the preparation of noodles. Control consisted of RWF noodles. Sensory quality and nutrient composition of finger millet noodles was evaluated. The 30% finger millet incorporated noodles were selected best on the basis of sensory evaluation. Noodles in that proportion along with control were evaluated for glycemic response. Nutrient composition of noodles showed that 50% finger millet incorporated noodles contained highest amount of crude fat (1.15%), total ash (1.40%), crude fiber (1.28%), carbohydrate (78.54%), physiological energy (351.36 kcal), insoluble dietary fiber (5.45%), soluble dietary fiber (3.71%), iron (5.58%) and calcium (88.39%), respectively. However, control RWF noodles contained highest amount of starch (63.02%), amylose (8.72%) and amylopectin (54.29%). The glycemic index (GI) of 30% finger millet incorporated noodles (best selected by sensory evaluation) was observed significantly lower (45.13) than control noodles (62.59). It was found that finger millet flour incorporated noodles were found nutritious and showed hypoglycemic effect. PMID:24587528

  17. Sensory Feedback Training for Improvement of Finger Perception in Cerebral Palsy

    Tobias Blumenstein

    2015-01-01

    Full Text Available Purpose. To develop and to test a feedback training system for improvement of tactile perception and coordination of fingers in children and youth with cerebral palsy. Methods. The fingers of 7 probands with cerebral palsy of different types and severity were stimulated using small vibration motors integrated in the fingers of a hand glove. The vibration motors were connected through a microcontroller to a computer and to a response 5-button keyboard. By pressing an appropriate keyboard button, the proband must indicate in which finger the vibration was felt. The number of incorrect responses and the reaction time were measured for every finger. The perception and coordination of fingers were estimated before and after two-week training using both clinical tests and the measurements. Results. Proper functioning of the developed system in persons with cerebral palsy was confirmed. The tactile sensation of fingers was improved in five of seven subjects after two weeks of training. There was no clear tendency towards improvement of selective use of fingers. Conclusion. The designed feedback system could be used to train tactile perception of fingers in children and youth with cerebral palsy. An extensive study is required to confirm these findings.

  18. Evaluation of nutraceutical and antinutritional properties in barnyard and finger millet varieties grown in Himalayan region.

    Panwar, Priyankar; Dubey, Ashutosh; Verma, A K

    2016-06-01

    Five elite varieties of barnyard (Echinochloa frumentacea) and finger (Eleusine coracana) growing at northwestern Himalaya were investigated for nutraceutical and antinutritional properties. Barnyard millet contained higher amount of crude fiber, total dietary fiber, tryptophan content, total carotenoids, α-tocopherol compared to the finger millet whereas the finger millet contains higher amount of methionine and ascorbic acid as compared to the barnyard millet. The secondary metabolites of biological functions were analyzed and found that barnyard millet contained the higher amount of polyphenols, tannins and ortho-dihydroxy phenol content compared to finger millet. Among antinutitional compounds barnyard millet contained lower phytic acid content compare to finger millet whereas no significant difference in trypsin inhibition activity of barnyard millet and finger millet varieties were found. Barnyard millet contained higher acid phosphatase, α-galactosidase and α-amylase inhibitor activity compared to finger millet. Finger millet seeds contained about 10-13 folds higher calcium content and double amount of manganese content in comparison to barnyard millet seeds. Present study suggests that barnyard millet varieties studied under present investigation were found nutritionally superior compared to finger millet varieties. PMID:27478234

  19. Stabilization of the total force in multi-finger pressing tasks studied with the ‘inverse piano’ technique

    Martin, J.R.; Budgeon, M.K.; Zatsiorsky, V.M.; Latash, M.L.

    2010-01-01

    When one finger changes its force, other fingers of the hand can show unintended force changes in the same direction (enslaving) and in the opposite direction (error compensation). We tested a hypothesis that externally imposed changes in finger force predominantly lead to error compensation effects in other fingers thus stabilizing the total force. A novel device, the “inverse piano”, was used to impose controlled displacements to one of the fingers over different magnitudes and at different rates. Subjects (n =10) pressed with four fingers at a constant force level and then one of the fingers was unexpectedly raised. The subjects were instructed not to interfere with possible changes in the finger forces. Raising a finger caused an increase in its force and a drop in the force of the other three fingers. Overall, total force showed a small increase. Larger force drops were seen in neighbors of the raised finger (proximity effect). The results show that multi-finger force stabilizing synergies dominate during involuntary reactions to externally imposed finger force changes. Within the referent configuration hypothesis, the data suggest that the instruction “not to interfere” leads to adjustments of the referent coordinates of all the individual fingers. PMID:21450360

  20. Stabilization of the total force in multi-finger pressing tasks studied with the 'inverse piano' technique.

    Martin, J R; Budgeon, M K; Zatsiorsky, V M; Latash, M L

    2011-06-01

    When one finger changes its force, other fingers of the hand can show unintended force changes in the same direction (enslaving) and in the opposite direction (error compensation). We tested a hypothesis that externally imposed changes in finger force predominantly lead to error compensation effects in other fingers thus stabilizing the total force. A novel device, the "inverse piano", was used to impose controlled displacements to one of the fingers over different magnitudes and at different rates. Subjects (n=10) pressed with four fingers at a constant force level and then one of the fingers was unexpectedly raised. The subjects were instructed not to interfere with possible changes in the finger forces. Raising a finger caused an increase in its force and a drop in the force of the other three fingers. Overall, total force showed a small increase. Larger force drops were seen in neighbors of the raised finger (proximity effect). The results showed that multi-finger force stabilizing synergies dominate during involuntary reactions to externally imposed finger force changes. Within the referent configuration hypothesis, the data suggest that the instruction "not to interfere" leads to adjustments of the referent coordinates of all the individual fingers. PMID:21450360

  1. Association Between Finger Patterns of Digit II and Intelligence Quotient Level in Adolescents

    Mostaf Najafi

    2009-09-01

    Full Text Available Objective: This study aimed at assessing the putative association between the fingertip patterns of right and left digits II and intellectual functioning. Methods:The study involves the evaluation of dermatoglyphic patterns on right and left digits II in 342 adolescents (144 talented ones, 102 normal individuals and 96 subjects with learning disabilities from the Shahrekord city in Iran. Comparisons between the frequencies of fingerprint patterns of each digit were made on the basis of two groups at a time employing Chi-square test. Findings:The most frequent dermatoglyphic pattern was whorl on both fingers in the 3 groups. An observation of right digit II revealed that the normal adolescents in comparison to the talented ones had a greater number of the whorl patterns (P=0.02, while the latter had more ulnar loops than the former (P=0.09. Group comprising those with learning disabilities had more ulnar loops than the group composed of the normal adolescents (P=0.09, and there was a predominance of radial loops among the talented subjects as opposed to those among the individuals with learning disabilities (P=0.002. There was no significant association in the relative frequencies of different finger patterns on left digit II between the groups (P>0.05. Conclusion:Our results support an association between some dermatoglyphic patterns observed on right digit II with IQ level in adolescents. Further researches, needless to say, especially employing various quantitative dermatoglyphic indices and larger-sized samples are recommended.

  2. Frequency spectrum analysis of finger photoplethysmographic waveform variability during haemodialysis

    This study investigates the peripheral circulatory and autonomic response to volume withdrawal in haemodialysis based on spectral analysis of photoplethysmographic waveform variability (PPGV). Frequency spectrum analysis was performed on the baseline and pulse amplitude variabilities of the finger infrared photoplethysmographic (PPG) waveform and on heart rate variability extracted from the ECG signal collected from 18 kidney failure patients undergoing haemodialysis. Spectral powers were calculated from the low frequency (LF, 0.04–0.145 Hz) and high frequency (HF, 0.145–0.45 Hz) bands. In eight stable fluid overloaded patients (fluid removal of >2 L) not on alpha blockers, progressive reduction in relative blood volume during haemodialysis resulted in significant increase in LF and HF powers of PPG baseline and amplitude variability (P < 0.01), when expressed in mean-scaled units. The augmentation of LF powers in PPGV during haemodialysis may indicate the recovery and possibly further enhancement of peripheral sympathetic vascular modulation subsequent to volume unloading, whilst the increase in respiratory HF power in PPGV is most likely a sign of preload reduction. Spectral analysis of finger PPGV may provide valuable information on the autonomic vascular response to blood volume reduction in haemodialysis, and can be potentially utilized as a non-invasive tool for assessing peripheral circulatory control during routine dialysis procedure

  3. LIPOMA OF HAND AND FINGER : A 6 PATIENT CASE SERIES

    Prakash Kumar

    2014-01-01

    Full Text Available INTRODUCTION: Lipoma , the ubiquitous benign tumor , is not very common in the hand and that to involving the palmar space or finger is very rare. This series of case presentation lays emphasis on consideration of lipoma in the differential diagnosis of swellings/ soft tissue tumors of the hand and the use o f imaging studies in their diagnosis. We report a ser ies of six cases of lipoma in different parts and planes of hand , involving palm and fingers . An uncommon site , size , shape , plane and age of occurrence of this common tumor warrants it’s reporting and an effort had been made to highlight the management. CONCLUSION : Hand lipoma is rare entity for a surgeon in the differential diagnosis of soft tissue tumors with radiology being an invaluable tool. Though rare but frequently seen in this pa rt of country , Precise surgical techniques with a sound anatomic knowledge helps in complete excision without damaging the vital structures and abates recurrences Lipoma , subcutaneous , mid - palmar space.

  4. Precuneus contributes to attentive control of finger movement

    Jing LUO; Kazuhisa NIKI; Zhi-guang DING; Yue-jia LUO

    2004-01-01

    AIM: To examine whether precuneus subserves the attentive control of finger movement or whether it mediates the movement preparation and motor inhibition. METHODS: In the Preparation Stage, subjects were shown with a 5-number string in which each number stood for a key-pressing response, the number strings included a complex pattern (eg, 4-1-4-2-3), or a simple one (eg, 2-2-2-2-2), or a null one (ie, x-x-x-x-x). In the Execution Stage, five reaction signs were presented one by one and subjects were required to press the corresponding key to each sign sequentially (eg, in the 4-1-4-2-3 preparation example, subjects press key 4 to the first sign, press key 1 to the second sign, key 4 to the third sign and so on). For the null preparation pattern, five numbers, rather than the reaction signs, were shown at the same pace as in the other two conditions and subjects were to press the corresponding keys. RESULTS: Left medial frontal gyrus (BA 6) and precentral gyrus (BA 6) were involved in both of the Preparation Stage and the Execution Stage, whereas left precuneus (BA 7) was activated only in the Execution Stage. CONCLUSION: Precuneus mediates the attentive control of finger movement, but not the movement preparation or motor inhibition.

  5. Trial manufacture of a plunger to reduce finger exposure

    According to the results of to a survey conducted by the Japanese Society of Nuclear Medicine Technology in 1995, the mean monthly exposure dose to the trunk of nuclear medicine technicians was less than 0.2 mSv at more than 75% of the institutions, whereas the exposure dose to the fingers exceeded 0.5 mSv at 30% of the institutions. Many recent radiopharmaceuticals are being supplied as the syringe type, and while the syringe is surrounded by a tungsten or lead-glass shield, there is no shielding of the syringe needle or the plungers. The plastic plunger provides little shielding effect, and even when a tungsten plunger is used, calculating back from the leakage rate, the shielding effect for 99mTc is approximately 75%. We therefore trial-manufactured a plunger devised in such a manner as to considerably reduce exposure of the fingers and evaluated its shielding effect from leakage rate obtained with a dual-detector scintillation camera when the radionuclides 99mTc, 67Ga, 201Tl, and 123I were used. Its performance was satisfactory, with shielding effects (99mTc, 99%; 67Ga, 95%, 201Tl, 95%; 123I, 73%) about the same or better than back-calculated from the leakage rates. (author)

  6. A new technique to determine vertical dimension of occlusion from anthropometric measurements of fingers

    Ruchi Ladda

    2013-01-01

    Full Text Available Purpose: The purpose of this study was to find the correlation between vertical dimension of occlusion (VDO and length of fingers. Materials and Methods: A cross-sectional study was conducted on 400 dentate subjects comprising of 200 males and 200 females. Anthropometric measurements of VDO, length of index finger, length of little finger, and distance from tip of thumb to tip of index finger of right hand were recorded clinically using modified digital vernier caliper. Correlation between VDO and length of fingers was studied using Spearman′s coefficient. For the execution of regression command and preparation of prediction equations to estimate VDO, Statistical Package for Social Sciences Software Version 11.5 was used. Results: VDO was significantly and positively correlated with all the parameters studied. In males, correlation of VDO was strongest for length of index finger (r-0.406 whereas in females, it was strongest for length of little finger (r-0.385. VDO estimation using regression equation had a standard error of ± 3.76 in males and ± 2.86 in females for length of index finger, ±3.81 and ± 2.74 in males and females respectively for length of little finger, ±3.99 and ± 2.89 in males and females respectively for distance from tip of thumb to tip of index finger. Conclusions: Since the variations between VDO and finger lengths are within the range of 2-4 mm, VDO prediction through this method is reliable, and reproducible. Also the method is simple, economic, and non-invasive; hence, it could be recommended for everyday practice.

  7. Determining the bias and variance of a deterministic finger-tracking algorithm.

    Morash, Valerie S; van der Velden, Bas H M

    2016-06-01

    Finger tracking has the potential to expand haptic research and applications, as eye tracking has done in vision research. In research applications, it is desirable to know the bias and variance associated with a finger-tracking method. However, assessing the bias and variance of a deterministic method is not straightforward. Multiple measurements of the same finger position data will not produce different results, implying zero variance. Here, we present a method of assessing deterministic finger-tracking variance and bias through comparison to a non-deterministic measure. A proof-of-concept is presented using a video-based finger-tracking algorithm developed for the specific purpose of tracking participant fingers during a psychological research study. The algorithm uses ridge detection on videos of the participant's hand, and estimates the location of the right index fingertip. The algorithm was evaluated using data from four participants, who explored tactile maps using only their right index finger and all right-hand fingers. The algorithm identified the index fingertip in 99.78 % of one-finger video frames and 97.55 % of five-finger video frames. Although the algorithm produced slightly biased and more dispersed estimates relative to a human coder, these differences (x=0.08 cm, y=0.04 cm) and standard deviations (σ x =0.16 cm, σ y =0.21 cm) were small compared to the size of a fingertip (1.5-2.0 cm). Some example finger-tracking results are provided where corrections are made using the bias and variance estimates. PMID:26174712

  8. An fMRI study during finger movement tasks and recalling finger movement tasks in normal subjects and schizophrenia patients

    Using fMRI, we investigated the region of the brain, which was activated by the finger movement tasks (F1) and the recalling finger movement tasks (F2). Six right-handed age-matched healthy controls and six Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) Schizophrenia patients were included in the study. In healthy controls, contralateral motor area, supplementary motor area and somatosensory area were all activated during F1 and F2. However the contralateral parietal lobe (supramarginal gyrus etc) and ipsilateral cerebellum were also activated during F2. In schizophrenia patients, the contralateral motor area was activated during F1, but the activated region was smaller than that observed in healthy subjects. During F2, the bilateral parietal lobes (sensorimotor cortices, association cortex) were activated, while the activated regions were smaller than those seen in healthy controls and no laterality was observed. In addition, no laterality of the activated regions was clearly observed. These results suggest that the function of recalling motor tasks can be mapped onto the contralateral motor area, somatosensory area, supplementary motor area, parietal association cortices, and ipsilateral cerebellum. In schizophrenia patients, the activated regions are smaller than those observed in healthy controls, and parietal regions are also activated bilaterally during recalling motor tasks. Schizophrenia patients may therefore process to recall motor task differently from healthy subjects while also demonstrate less laterality of the brain. (author)

  9. In Vitro Wear Testing of a CoCr-UHMWPE Finger Prosthesis with Hydroxyapatite Coated CoCr Stems

    Andrew Naylor

    2015-04-01

    Full Text Available A finger prosthesis consisting of a Cobalt-chromium (CoCr proximal component and an Ultra-high-molecular-weight-polyethylene (UHMWPE medial component (both mounted on hydroxyapatite coated stems was evaluated to 5,000,000 cycles in an in vitro finger simulator. One “test” prosthesis was cycled through flexion-extension (90°–30° with a dynamic load of 10 N, whilst immersed in a lubricant of dilute bovine serum. Additionally, a static load of 100 N was applied for 45 s every 3000 cycles to simulate a static gripping force. A second “control” prosthesis was immersed in the same lubricant to account for absorption. Gravimetric and Sa (3D roughness measurements were taken at 1,000,000 cycle intervals. Micrographs and Sa values revealed negligible change to the CoCr surfaces after 5,000,000 cycles. The UHMWPE also exhibited no distinctive Sa trend, however the micrographs indicate that polishing occurred. Both the CoCr and UHMWPE test components progressively decreased in weight. The CoCr control component did not change in weight, whilst the UHMWPE component gained weight through absorption. To account for the disparity between surface and gravimetric results, the hydroxyapatite coatings were examined. Micrographs of the test stems revealed that the hydroxyapatite coating was partially removed, whilst the micrographs of the control stems exhibited a uniform coating.

  10. Chemically synthesized zinc finger molecules as nano-addressable probes for double-stranded DNAs

    Christmann Alexander

    2005-06-01

    Full Text Available Abstract Our experiments describe an alternative method of dsDNA recognition using zinc finger (ZF molecules which bind DNA specifically and with high affinity. Our aim was to develop zinc finger probes which are able to bind to dsDNA molecules at predetermined sites. In our basic approach we used pairs of complementary oligonucleotides to form dsDNAs, containing one of the three SP1-transcription factor motifs as a zinc finger recognition site. Two zinc finger probes of the SP1 motif were chemically synthesized and modified with a Dy-633 fluorophore. The SP1 peptides were folded into functional zinc fingers using zinc chloride. The addressable dsDNAs were immobilized on optical fibres, and the kinetics and binding rates of the artificial zinc finger probes were measured by a fluorescence detecting device (photomultiplying tube. The two zinc fingers and their corresponding DNA recognition sites served as specific probes and controls for the matching site and vice versa. Our experiments showed that a variety of dsDNA-binding probes may be created by modification of the amino acid sequence of natural zinc finger proteins. Our findings offer an alternative approach of addressing dsDNA molecules, for example for use in a nanoarray device.

  11. Neural network committees for finger joint angle estimation from surface EMG signals

    Reddy Narender P

    2009-01-01

    Full Text Available Abstract Background In virtual reality (VR systems, the user's finger and hand positions are sensed and used to control the virtual environments. Direct biocontrol of VR environments using surface electromyography (SEMG signals may be more synergistic and unconstraining to the user. The purpose of the present investigation was to develop a technique to predict the finger joint angle from the surface EMG measurements of the extensor muscle using neural network models. Methodology SEMG together with the actual joint angle measurements were obtained while the subject was performing flexion-extension rotation of the index finger at three speeds. Several neural networks were trained to predict the joint angle from the parameters extracted from the SEMG signals. The best networks were selected to form six committees. The neural network committees were evaluated using data from new subjects. Results There was hysteresis in the measured SMEG signals during the flexion-extension cycle. However, neural network committees were able to predict the joint angle with reasonable accuracy. RMS errors ranged from 0.085 ± 0.036 for fast speed finger-extension to 0.147 ± 0.026 for slow speed finger extension, and from 0.098 ± 0.023 for the fast speed finger flexion to 0.163 ± 0.054 for slow speed finger flexion. Conclusion Although hysteresis was observed in the measured SEMG signals, the committees of neural networks were able to predict the finger joint angle from SEMG signals.

  12. Nature and Culture of Finger Counting: Diversity and Representational Effects of an Embodied Cognitive Tool

    Bender, Andrea; Beller, Sieghard

    2012-01-01

    Studies like the one conducted by Domahs et al. (2010, in Cognition) corroborate that finger counting habits affect how numbers are processed, and legitimize the assumption that this effect is culturally modulated. The degree of cultural diversity in finger counting, however, has been grossly underestimated in the field at large, which, in turn,…

  13. Women's finger sensitivity correlates with partnered sexual behavior but not solitary masturbation frequencies

    S. Brody; A.H. Fischer; U. Hess

    2008-01-01

    In a sample of 97 healthy Dutch female university students, women with greater finger tactile sensitivity (von Frey-type filaments) engaged more in partnered (but not solitary masturbation) sexual behavior. Orgasmic responses in the past 30 days were not correlated with finger sensitivity. Results a

  14. Blood pressure measurement of all five fingers by strain gauge plethysmography

    Hirai, M; Nielsen, S L; Lassen, N A

    1976-01-01

    The aim of the present paper was to study the methodological problems involved in measuring systolic blood pressure in all five fingers by the strain gauge technique. In 24 normal subjects, blood pressure at the proximal phalanx of finger I and both at the proximal and the intermediate phalanx of...

  15. The Power of a Soccer Ball: A Traumatic Open Finger Dislocation—A Rare Case Presentation

    Turan Cihan Dülgeroğlu

    2015-01-01

    Full Text Available Proximal interphalangeal joint dislocations are injuries observed frequently and caused by axial loading on the finger in the extension. In this paper we present a traumatic open finger dislocation due to a ball hitting a wrestler. It was successfully treated with reduction and the volar plate and collateral bond fixation were applied with absorbable sutures.

  16. Birth Outcomes across Three Rural-Urban Typologies in the Finger Lakes Region of New York

    Strutz, Kelly L.; Dozier, Ann M.; van Wijngaarden, Edwin; Glantz, J. Christopher

    2012-01-01

    Purpose: The study is a descriptive, population-based analysis of birth outcomes in the New York State Finger Lakes region designed to determine whether perinatal outcomes differed across 3 rural typologies. Methods: Hospital birth data for the Finger Lakes region from 2006 to 2007 were used to identify births classified as low birthweight (LBW),…

  17. 21 CFR 888.3210 - Finger joint metal/metal constrained cemented prosthesis.

    2010-04-01

    ... prosthesis. 888.3210 Section 888.3210 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... metal/metal constrained cemented prosthesis. (a) Identification. A finger joint metal/metal constrained cemented prosthesis is a device intended to be implanted to replace a metacarpophalangeal (finger)...

  18. Changes in finger-aorta pressure transfer function during and after exercise

    W.J. Stok; B.E. Westerhof; J.M. Karemaker

    2006-01-01

    Changes in finger-aorta pressure transfer function during and after exercise. J Appl Physiol 101: 1207-1214, 2006. First published June 1, 2006; doi:10.1152/japplphysiol.00876.2005.-Noninvasive finger blood pressure has become a surrogate for central blood pressure under widely varying circumstances

  19. Surgery versus ultrasound-guided steroid injections for trigger finger disease

    Hansen, Rehne L; Lange, Jeppe

    2013-01-01

    a trigger finger score. Furthermore, any treatment complications, absence from work or sport and use of related medical services or additional treatment are also recorded. DISCUSSION: The present study will be the first to compare treatment of trigger finger by conventional open surgery with ultrasound...

  20. Dermatoglyphic analysis of La Liébana (Cantabria, Spain). 2. Finger ridge counts.

    Martín, J; Gómez, P

    1993-06-01

    The results of univariate and multivariate analyses of the quantitative finger dermatoglyphic traits (i.e. ridge counts) of a sample of 109 males and 88 females from La Liébana (Cantabria, Spain) are reported. Univariate results follow the trends usually found in previous studies, e.g., ranking of finger ridge counts, bilateral asymmetry or shape of the distributions of the frequencies. However, sexual dimorphism is nearly inexistent concerning finger ridge counts. This lack of dimorphism could be related to certain characteristics of the distribution of finger dermatoglyphic patterns previously reported by the same authors. The multivariate description has been carried out by means of principal component analysis (with varimax rotation to obtain the final solution) of the correlation matrices computed from the 10 maximal finger ridge counts. Although the results do not necessarily prove the concept of developmental fields ("field theory" and later modifications), some precepts of the theory are present: field polarization and field overlapping. PMID:8333735

  1. The Case Report of Trigger Finger Improved with Hominis Placenta Pharmacopuncture Treatment

    Jeong-Won Kim

    2010-12-01

    Full Text Available Objectives : The Purpose of this study is to investigate and report the effectiveness of Hominis Placenta using Pharmacopuncture treatment for trigger finger. Methods : 3 Patients are admitted at Dept. of Oriental Rehabilitation, Bu-Chun Jaseng Oriental Medicine Hospital, diagnosed as Trigger finger and treated with Hominis Placenta Pharmacopuncture. Each cases are measured and assessed by Quinnell's classification of triggering and VAS (Visual Analogue Scale scores. Results : 3 Patients of trigger finger have a different kind of cause and fingers lesion they have, but nodules are not significantly found up, so we could classify all of 3 patients to diffuse type. After treatment of Hominis placenta Pharmacopuncture, spontaneous pain and tenderness, grades of triggering are decreased significantly. We would expect that Hominis placenta Pharmacopuncture has a effect on degenerative diseases of diffuse type's tendon sheath. Conclusions : Trigger finger is generally divided into two stages, inflammatory and degenerative stage, and when degenerative stage, Hominis placenta pharmacopuncture appears to be effective.

  2. [Spinal epidural abscess as a complication of a finger infection].

    Ridderikhof, M L; van den Brink, W A; van Dalsen, A D; Kieft, H

    2008-06-21

    An 81-year-old man was treated with intravenous antibiotics for a soft tissue infection in a finger. Despite adequate antibiotic treatment, he developed signs of spinal cord injury caused by a cervical spinal epidural abscess. An emergency laminectomy was performed. The neurological impairment appeared to be irreversible, and the patient died. Spinal epidural abscess is a rare and serious complication ofa bacteraemia. It is often caused by an infection of the skin or soft tissue with Staphylococcus aureus. Given the risk of rapidly progressive and irreversible neurological damage, this complication must be treated as soon as possible. The treatment of choice is surgery. Conservative management with intravenous antibiotics is an option only under strict conditions. PMID:18624007

  3. Analysis of the dynamic hysteresis characteristic of finger seal

    LEI Yanni; CHEN Guoding

    2007-01-01

    The research about hysteresis characteristic of finger seal (FS), which was carried out based on the model with static loads, could not reflect the dynamics behavior of FS system when the rotor runs at high speed. To solve this problem, the relations between the dynamics parameters, structure parameters as well as working parameters in the system were given out through the analysis of finite element analysis result. A mass-spring-damper dynamics model of FS system was proposed and the hysteresis characteristic of the FS system was analyzed. This work shows that the dynamics characteristic analysis of the FS is necessary and the dynamics model proposed in this paper is valid. This dynamics model is the basis for the optimization design of FS system.

  4. Acute idiopathic blue fingers: a young man with Achenbach's syndrome.

    Takeuchi, Hidemi; Uchida, Haruhito Adam; Okuyama, Yuka; Wada, Jun

    2016-01-01

    We report a case of a 20-year-old man presenting with acute painful blue fingers. All physical findings, including an Allen test, were normal, and systematic symptoms frequently seen in collagen diseases were absent. Although we performed a wide variety of investigations including medical imaging, no specific abnormal findings were observed. Skin biopsy pathology was an important reference. The patient's symptoms gradually improved and were completely resolved without specific treatment. Based on the clinical presentation and course, we gave a diagnosis of Achenbach's syndrome, developed in a young male. Achenbach's syndrome is rare, but still may be encountered in clinical practice. The symptoms can be startling to the patient, eliciting fear of something terrible when, in fact, the syndrome is relatively benign and has a good prognosis. Recognising this disease quickly after presentation helps to eliminate the anxiety of the patient, as well as reducing excessively invasive investigations. We present a case report to enlighten Achenbach's syndrome. PMID:27090544

  5. "Finger" structure of tiles in CMS Endcap Hadron Calorimeters

    Afanasiev, Sergey; Danilov, Mikhail; Emeliantchik, Igor; Ershov, Yuri; Golutvin, Igor; Grinyov, B.V; Ibragimova, Elvira; Levchuk, Leonid; Litomin, Aliaksandr; Makankin, Alexander; Malakhov, Alexander; Moisenz, Petr; Nuritdinov, I; Popov, V.F; Rusinov, Vladimir; Shumeiko, Nikolai; Smirnov, Vitaly; Sorokin, Pavlo; Tarkovskiy, Evgueni; Tashmetov, A; Vasiliev, S.E; Yuldashev, Bekhzod; Zamyatin, Nikolay; Zhmurin, Petro

    2015-01-01

    Two CMS Endcap hadron calorimeters (HE) have been in operation for several years and contributed substantially to the success of the CMS Physics Program. The HE calorimeter suffered more from the radiation than it had been anticipated because of rapid degradation of scintillator segments (tiles) which have a high radiation flux of secondary particles. Some investigations of scintillators have shown that the degradation of plastic scintillator increases significantly at low dose rates. A proposal to upgrade up-grade the HE calorimeter has been prepared to provide a solution for survivability of the future LHC at higher luminosity and higher energy. A finger-strip plastic scintillator option has many advantages and is a lower cost alternative to keep the excellent HE performance at high luminosity. Measurements have been performed and this method has proved to be a good upgrade strategy.

  6. Miscible viscous fingering involving production of gel by chemical reactions

    Nagatsu, Yuichiro; Hoshino, Kenichi

    2015-11-01

    We have experimentally investigated miscible viscous fingering with chemical reactions producing gel. Here, two systems were employed. In one system, sodium polyacrylate (SPA) solution and aluminum ion (Al3 +) solution were used as the more and less viscous liquids, respectively. In another system, SPA solution and ferric ion (Fe3 +) solution were used as the more and less viscous liquids, respectively. In the case of Al3 +, displacement efficiency was smaller than that in the non-reactive case, whereas in the case of Fe3 +, the displacement efficiency was larger. We consider that the difference in change of the patterns in the two systems will be caused by the difference in the properties of the gels. Therefore, we have measured the rheological properties of the gels by means of a rheometer. We discuss relationship between the VF patterns and the rheological measurement.

  7. Severe onychophagia and finger mutilation associated with obstructive sleep apnea.

    Nino, Gustavo; Singareddy, Ravi

    2013-04-15

    Untreated obstructive sleep apnea (OSA) can lead to important neurobehavioral consequences including cognitive deficits, hyperactivity/inattention, daytime sleepiness, and mood disturbances. Interestingly, the potential role of OSA in the pathogenesis of impulse-control disorders such as nail biting (onychophagia) is currently unknown. We present a case of a man with severe onychophagia and biting-induced finger mutilation that was completely resolved after diagnosis and treatment of severe OSA. Accordingly, this report represents an important clinical observation that suggests a connection between sleep physiology and the neurobiological circuits implicated in the regulation of impulse-control behaviors. Further research in this area may improve our current understanding of the neurobehavioral consequences of untreated OSA. PMID:23585754

  8. HIT anthropomorphic robotic hand and finger motion control

    2006-01-01

    Nowadays many anthropomorphic robotic hands have been put forward. These hands emphasize different aspects according to their applications. HIT Anthropomorphic Robotic Hand (ARhand) is a simple,lightweight and dexterous design per the requirements of anthropomorphic robots. Underactuated self-adaptive theory is adopted to decrease the number of motors and weight. The fingers of HIT ARhand with multi phalanges have the same size as those of an adult hand. Force control is realized with the position sensor, joint torque sensor and fingertip torque sensor. From the 3D model, the whole hand, with the low power consumption DSP control board integrated in it, will weigh only 500 g. It will be assembled on a BIT-Anthropomorphic Robot.

  9. Molecular Cloning and Expression Analysis of a Cys2/His2 Type Zinc Finger Protein Gene in Upland Cotton

    2008-01-01

    The zinc finger proteins belong to the largest family of transcription factors.But there is little research of Cys2/His2 type zinc finger proteins in cotton,and there is no submission of correlating ESTs

  10. Single trial discrimination of individual finger movements on one hand: a combined MEG and EEG study.

    Quandt, F; Reichert, C; Hinrichs, H; Heinze, H J; Knight, R T; Rieger, J W

    2012-02-15

    It is crucial to understand what brain signals can be decoded from single trials with different recording techniques for the development of Brain-Machine Interfaces. A specific challenge for non-invasive recording methods are activations confined to small spatial areas on the cortex such as the finger representation of one hand. Here we study the information content of single trial brain activity in non-invasive MEG and EEG recordings elicited by finger movements of one hand. We investigate the feasibility of decoding which of four fingers of one hand performed a slight button press. With MEG we demonstrate reliable discrimination of single button presses performed with the thumb, the index, the middle or the little finger (average over all subjects and fingers 57%, best subject 70%, empirical guessing level: 25.1%). EEG decoding performance was less robust (average over all subjects and fingers 43%, best subject 54%, empirical guessing level 25.1%). Spatiotemporal patterns of amplitude variations in the time series provided best information for discriminating finger movements. Non-phase-locked changes of mu and beta oscillations were less predictive. Movement related high gamma oscillations were observed in average induced oscillation amplitudes in the MEG but did not provide sufficient information about the finger's identity in single trials. Importantly, pre-movement neuronal activity provided information about the preparation of the movement of a specific finger. Our study demonstrates the potential of non-invasive MEG to provide informative features for individual finger control in a Brain-Machine Interface neuroprosthesis. PMID:22155040

  11. Effects of Parkinson’s disease on optimization and structure of variance in multi-finger tasks

    Park, Jaebum; Jo, Hang Jin; Lewis, Mechelle M.; Huang, Xuemei; Latash, Mark L.

    2013-01-01

    We explored the role of the basal ganglia in two components of multi-finger synergies by testing a group of patients with early-stage Parkinson’s disease and a group of healthy controls. Synergies were defined as co-varied adjustments of commands to individual fingers that reduced variance of the total force and moment of force. The framework of the uncontrolled manifold hypothesis was used to quantify such co-variation patterns, while average performance across repetitive trials (sharing patterns) was analyzed using the analytical inverse optimization (ANIO) approach. The subjects performed four-finger pressing tasks that involved the accurate production of combinations of the total force and total moment of force and also repetitive trials at two selected combinations of the total force and moment. The ANIO approach revealed significantly larger deviations of the experimental data planes from an optimal plane for the patients compared to the control subjects. The synergy indices computed for total force stabilization were significantly higher in the control subjects compared to the patients; this was not true for synergy indices computed for moment of force stabilization. The differences in the synergy indices were due to the larger amount of variance that affected total force in the patients, while the amount of variance that did not affect total force was comparable between the groups. We conclude that the basal ganglia play an important role in both components of synergies reflecting optimization of the sharing patterns and stability of performance with respect to functionally important variables. PMID:23942616

  12. Perseveration Found in a Human Drawing Task: Six-Fingered Hands Drawn by Patients with Right Anterior Insula and Operculum Damage

    Chiharu Niki

    2014-01-01

    Full Text Available Background. Perseveration has been observed in a number of behavioural contexts, including speaking, writing, and drawing. However, no previous report describes patients who show perseveration only for drawing a human figure. Objective. The present report describes a group of patients who show body awareness-related cognitive impairment during a human figure drawing task, a different presentation from previously described neuropsychological cases. Methods. Participants were 15 patients who had a frontal lobe brain tumour around the insula cortex of the right hemisphere and had subsequently undergone a neurosurgical resective operation. Participants were asked to draw a human figure in both “hands-down” and “hands-up” configurations. Results. Eight of the 15 patients drew a human figure with six fingers during the “hands-up” and the “hands-down” human figure drawing tasks (one patient drew eight fingers. A statistical analysis of potential lesion areas revealed damage to the right anterior frontal insula and operculum in this group of patients relative to the five-finger drawing group. Conclusions. Our findings reveal a newly described neuropsychological phenomenon that could reflect impairment in attention directed towards body representations.

  13. Mathematics revealed

    Berman, Elizabeth

    1979-01-01

    Mathematics Revealed focuses on the principles, processes, operations, and exercises in mathematics.The book first offers information on whole numbers, fractions, and decimals and percents. Discussions focus on measuring length, percent, decimals, numbers as products, addition and subtraction of fractions, mixed numbers and ratios, division of fractions, addition, subtraction, multiplication, and division. The text then examines positive and negative numbers and powers and computation. Topics include division and averages, multiplication, ratios, and measurements, scientific notation and estim

  14. Revealed Attention

    Masatlioglu, Yusufcan; NAKAJIMA, Daisuke; Ozbay, Erkut Y

    2012-01-01

    The standard revealed preference argument relies on an implicit assumption that a decision maker considers all feasible alternatives. The marketing and psychology literatures, however, provide wellestablished evidence that consumers do not consider all brands in a given market before making a purchase (Limited Attention). In this paper, we illustrate how one can deduce both the decision maker's preference and the alternatives to which she pays attention and inattention from the observed behav...

  15. Revealed Attention

    Yusufcan Masatlioglu; Daisuke Nakajima; Ozbay, Erkut Y

    2012-01-01

    The standard revealed preference argument relies on an implicit assumption that a decision maker considers all feasible alternatives. The marketing and psychology literatures, however, provide well-established evidence that consumers do not consider all brands in a given market before making a purchase (Limited Attention). In this paper, we illustrate how one can deduce both the decision maker's preference and the alternatives to which she pays attention and inattention from the observed beha...

  16. Optimize design dexterity of tooth-arrangement three-fingered hands

    Wang, Hai-ying; Zhang, Li-yong; Zhang, Yong-de

    2005-12-01

    "Tooth-arrangement Three-fingered Hands" is a brand-new oral cavity repairing robot. It has the functions of fine grasping and arranging artificial tooth, manufacturing complete denture, etc. A new optimization design method is proposed in this paper that solves the problems in optimization structure parameter confirming and optimal dexterous design. The bionic theorem behind duplicating the dexterity of the human finger is incorporated into the structure parameter optimization algorithm. Through analyzing the dexterity of the single finger, adopting the design criteria of dexterous degree with optimum index and combining the characteristic of grasping the smallest object, this design method can confirm the best dexterity area for single finger, relations between every rod length and rotation range of every joint. Using MATLAB optimization toolbox to optimize above-mentioned structure parameter, it gains the optimal dimension that meets characteristic of human fingers and can finish grasping. A quantitative method is also proposed in this paper to calculate the relative position between fingers. It is applied to the real design of Tooth-Arrangement Three-fingered Hands and obtained optimal flexible performance.

  17. Prehension Kinematics, Grasping Forces, and Independent Finger Control in Mildly Affected Patients with Essential Tremor.

    Solbach, Kasja; Mumm, Mareike; Brandauer, Barbara; Kronenbürger, Martin; Hermsdörfer, Joachim; Timmann, Dagmar

    2016-08-01

    Although the pathophysiology of essential tremor (ET), one of the most common movement disorders, is not fully understood, evidence increasingly points to cerebellar involvement. To confirm this connection, we assessed the everyday hand and finger movements of patients with ET, as these movements are known to be affected in cerebellar diseases. In 26 mildly affected patients with ET (compared to age- and gender-matched controls), kinematic and finger force parameters were assessed in a precision grip. In a second task, independent finger movements were recorded. The active finger had to press and release against a force-sensitive keypad while the other fingers stayed inactive. Finally, control of grip force to movement-induced, self-generated load changes was studied. Transport and shaping components during prehension were significantly impaired in patients with ET compared to controls. No significant group differences were observed in independent finger movements and grip force adjustments to self-generated load force changes. However, in the latter two tasks, more severely affected ET patients performed worse than less affected. Although observed deficits in hand and finger movement tasks were small, they are consistent with cerebellar dysfunction in ET. Findings need to be confirmed in future studies examining more severely affected ET patients. PMID:26310449

  18. Measurements of fingers doses in X-ray guided surgery, nuclear medicine and research

    The Norwegian Radiation Protection Authority has performed measurements of finger doses to nuclear medicine staff exposed to 99Tcm, researchers handling 32P, Surgeons performing X-ray guided orthopaedic surgery and surgeons and radiologists performing X-ray guided endovascular treatment of abdominal aortic aneurysms (AAA). Calibrations were done with X-ray qualities N-40, N-60 and N-300 and with the beta source 90Sr + 90Y. Annual doses were estimated for the nuclear medicine staff and the orthopaedic surgeons. The mean annual finger dose to nuclear medicine staff exposed to 99Tcm was estimated to be 18.8 mSv, and the mean annual finger dose to surgeons performing X-ray guided orthopaedic surgery was 13.7 mSv. The surgeons and radiologists performing X-ray guided endovascular treatment of AAA received a mean finger dose of 0.35 mSv per treatment. The majority of researchers handling 32P received no finger dose at all, and the maximum reading was 1.65 mSv. All occupational groups received finger doses well below the annual finger dose limit of 500 mSv. (authors)

  19. Computational study of effect of water finger on ion transport through water-oil interface

    Kikkawa, Nobuaki; Wang, Lingjian; Morita, Akihiro

    2016-07-01

    When an ion transports from water to oil through water-oil interface, it accompanies hydrated water molecules and transiently forms a chain of water, called "water finger." We thoroughly investigated the role of the water finger in chloride ion transport through water-dichloromethane interface by using molecular dynamics technique. We developed a proper coordinate w to describe the water finger structure and calculated the free energy landscape and the friction for the ion transport as a function of ion position z and the water finger coordinate w. It is clearly shown that the formation and break of water finger accompanies an activation barrier for the ion transport, which has been overlooked in the conventional free energy curve along the ion position z. The present analysis of the friction does not support the hypothesis of augmented local friction (reduced local diffusion coefficient) at the interface. These results mean that the experimentally observed rate constants of interfacial ion transfer are reduced from the diffusion-limited one because of the activation barrier associated to the water finger, not the anomalous local diffusion. We also found that the nascent ion just after the break of water finger has excessive hydration water than that in the oil phase.

  20. Identification of a novel zinc finger protein gene (ZNF298) in the GAP2 of human chromosome 21q

    We have isolated a novel zinc finger protein gene, designated ZNF298, as a candidate gene for a particular phenotype of Down syndrome or bipolar affective disorder (BPAD) which maps to human chromosome 21q22.3. ZNF298 gene consists of 25 exons spanning approximately 80 kb in a direction from the telomere to centromere. There are four kinds of transcripts that harbor three types of 3' UTR. These four transcripts (ZNF298a, ZNF298b, ZNF298c, and ZNF298d) contain putative open reading frames encoding 1178, 1198, 555, and 515 amino acids, respectively. ZNF298 gene was ubiquitously expressed in various tissues at very low level. The protein motif analysis revealed that ZNF298 proteins contain a SET [Su(var)3-9, Enhancer-of-zeste, Trithorax] domain, multiple C2H2-type zinc finger (ZnFC2H2) domains, several nuclear localization signals (NLSs), and PEST sequences. Nuclear localization of ZNF298 protein was confirmed by transfection of expression vector of GFP-tagged protein into two human cell lines. Interestingly, this gene crosses over a clone gap (GAP2) remaining in the band 21q22.3. We obtained the DNA fragments corresponding to GAP2 using ZNF298 cDNA sequence as anchor primers for PCR and determined its genomic DNA sequence

  1. Evidence evaluation in fingerprint comparison and automated fingerprint identification systems--Modeling between finger variability.

    Egli Anthonioz, N M; Champod, C

    2014-02-01

    In the context of the investigation of the use of automated fingerprint identification systems (AFIS) for the evaluation of fingerprint evidence, the current study presents investigations into the variability of scores from an AFIS system when fingermarks from a known donor are compared to fingerprints that are not from the same source. The ultimate goal is to propose a model, based on likelihood ratios, which allows the evaluation of mark-to-print comparisons. In particular, this model, through its use of AFIS technology, benefits from the possibility of using a large amount of data, as well as from an already built-in proximity measure, the AFIS score. More precisely, the numerator of the LR is obtained from scores issued from comparisons between impressions from the same source and showing the same minutia configuration. The denominator of the LR is obtained by extracting scores from comparisons of the questioned mark with a database of non-matching sources. This paper focuses solely on the assignment of the denominator of the LR. We refer to it by the generic term of between-finger variability. The issues addressed in this paper in relation to between-finger variability are the required sample size, the influence of the finger number and general pattern, as well as that of the number of minutiae included and their configuration on a given finger. Results show that reliable estimation of between-finger variability is feasible with 10,000 scores. These scores should come from the appropriate finger number/general pattern combination as defined by the mark. Furthermore, strategies of obtaining between-finger variability when these elements cannot be conclusively seen on the mark (and its position with respect to other marks for finger number) have been presented. These results immediately allow case-by-case estimation of the between-finger variability in an operational setting. PMID:24447455

  2. Suppress the Finger Reflection Error of Littlewood-pelay Wavelet Transformation Device of Surface Acoustic Wave

    Li Yuanyuan

    2013-01-01

    Full Text Available In this study, a Wavelet Transformation (WT device of Surface Acoustic Wave (SAW technology is developed on the basis of acoustics, electronics, wavelet theory, applied mathematics and semiconductor planar technology. The Finger Reflection (FR error is the primary reason for this kind of device. To solve the problem, a mathematic model of Littlewood-pelay wavelet was established first, which is matched with the model of SAW. Using the methods of split finger and fake finger to design IDT of Littlewood-pelay WT device of SAW with L-edit software, the FR error can be reduced and the equivalent construction of IDT is simulated.

  3. The TASERed finger: A new entity. Case report and review of literature.

    Dunet, B; Erbland, A; Abi-Chahla, M-L; Tournier, C; Fabre, T

    2015-06-01

    The TASER(®) is a self-defense weapon whose use has now become commonplace among law enforcement agencies. Electronic control weapons were first used in the USA in the 1990s and then adopted in Europe and France. We report a case of an 18-year-old male who presented a penetrating lesion of the middle phalanx of the left index finger. To the best of our knowledge, this is the first complex finger injury due to the TASER(®). It highlights the potential major risks to finger vitality and function with use of this electrical weapon. PMID:25958324

  4. DIGIT FORCE ADJUSTMENTS DURING FINGER ADDITION/REMOVAL IN MULTI-DIGIT PREHENSION

    Budgeon, Mark K.; Mark L. Latash; Zatsiorsky, Vladimir M.

    2008-01-01

    We explored adjustments in multi-digit coordinated action on a hand-held object with finger addition and removal. The subjects (n= 7) kept a vertically oriented handle at rest using a prismatic grasp as if holding a glass of liquid and then either added one finger to the grasp—the index (I) or little (L) finger—or removed one finger. Three external torques were applied on the apparatus: clockwise, counterclockwise, and no torque. The individual digit forces and moments were recorded with 6-co...

  5. Modeling of Current-gain Collapse in Multi-finger HBT ’s

    Garlapati, Akhil; Prasad, Sheila

    2000-01-01

    This paper presents an equivalent circuit model for common-emitter current-gain collapse in multi-finger HBTs.The collapse of current-gain is an undesirable phenomenon,which occurs in multi-finger HBTs when they are operated at high power density.The collapse manifests itself by a distinct abrupt decrease of collector current in the output characteristics of the HBT.Until now,there hasn ’t been an equivalent circuit model to simulate the current collapse behavior of multi-finger HBTs.In this ...

  6. Control System Design of the YWZ Multi-fingered Dexterous Hand

    Wenzhen Yang; Shiguang Yu; Hua Zhang; Wenhua Chen

    2012-01-01

    The manipulation abilities of a multi‐fingered dexterous hand, such as motion in real‐time, flexibility, grasp stability etc., are largely dependent on its control system. This paper developed a control system for the YWZ dexterous hand, which had five fingers and twenty degrees of freedom (DOFs). All of the finger joints of the YWZ dexterous handwere active joints driven by twenty micro‐stepper motors respectively. The main contribution of this paper was that we were able to use stepper moto...

  7. Ultrasonography of the trigger fingers: Emphasis on findings of annular pulley

    Chung, Hye Won [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2003-06-15

    To analyze the sonographic findings of clinically diagnosed trigger fingers by comparing those of normal fingers with a special emphasis on findings of the annular pulleys that has not been demonstrated previously. Forty-four fingers of 38 patients with clinically diagnosed trigger fingers and 31 asymptomatic contralateral fingers from 29 patients as the normal control group were included in this study. The mean age of the subjects with trigger fingers was 39 years (age range, 7-74 years; female:male = 32:6) while that of the normal control group, 49 years (age range, 7-74 years; female:male = 24:5). Longitudinal and axial images of the flexor digitorum tendons (FDTs) and adjacent soft tissue were obtained with a careful examination of the annular pulleys including A1 pulley. Two radiologists conducted a retrospective analysis of sonographic findings with an emphasis on the visualization and thickness of annular pulleys, thickness and echo pattern of FDTs, distension of tendon sheath , and presence of ganglion. Statistical significances for the difference of thickness of the annular pulleys and FDTs between patients and normal control group were determined with independent sample t-test. The probability value less than .05 was considered statistically significant. Twenty-six of 44 fingers (59%) showed thickened annular pulleys (A1 in 20 and A3 in 6 cases). The thickness of annular pulleys of control and patient groups was 0.27 +- 0.40 mm and 0.77 +- 85 mm, respectively. The average thickness of FDTs of the control and patient groups were 3.35+- 0.77 mm and 3.6 +- 0.9 mm, respectively. The annular pulleys were thickened in the patient group with a statistical significance (p<0.05) whereas the thickness of FDTs did not. The echo pattern of FDTs was normal in 38 fingers of 44 patients (86%) while only six remaining fingers (14%) showed decreased echo and loss of the normal fibrillary pattern within the tendon. Three fingers showed distension of tendon sheath; one

  8. Finger temperature as a predictor of thermal comfort for sedentary passengers in a simulated aircraft cabin

    Strøm-Tejsen, Peter; Wyon, David Peter; Zukowska, Daria;

    2009-01-01

    .1°C. A total of 68 subjects were exposed to each of the three conditions. The subjects completed questionnaires to provide subjective assessments of air quality, cabin environment, intensity of symptoms commonly experienced during flight, and thermal comfort. Objective physiological measurements that...... were made included finger temperature. The purpose of the present paper is to show that mean finger temperature is a good predictor of mean thermal vote (MTV) on the seven-point scale of thermal sensation. The results indicate that women and younger subjects have slightly colder fingers....

  9. Damping effects of capacitive comb fingers on biomimetic MEMS directional microphone

    Roth, John; Touse, Michael; Sinibaldi, Jose; Karunasiri, Gamani

    2011-03-01

    MEMS directional sound sensors that use two coupled wings moving in air are subjected to viscous damping. The amplitude of oscillation of the sensors is read out by measuring the capacitance of interdigitated comb fingers along the edges of the wings. In this presentation, effects of damping on MEMS sensors with and without comb fingers will be described. It was found that the sensors with comb fingers have a significantly larger damping indicating that the longer perimeter due to combs is responsible for the observed increase. However, the increase in damping reduces the quality factor which improves the response time of the device. This work is supported by NSF.

  10. High-resolution MRI with a microscopy coil for carpal tunnel syndrome patients. Morphological changes in the carpal canal during finger motion

    Thickening of the flexor tendon synovium has been considered as the cause of idiopathic carpal tunnel syndrome; however, this pathogenesis has not been clarified. We investigated the dynamic morphological changes in the carpal canal during finger motion by using high-resolution MRI with a microscopy coil. We examined 11 wrists of 10 patients. They were diagnosed with idiopathic carpal tunnel syndrome based on clinical symptoms and electrophysiological examination, and they finally underwent carpal canal release surgery. The patients were all females and the mean age was 59.1 years. As a control group, 9 wrists of 9 asymptomatic individuals were also examined. The control group consisted of 6 males and 3 females, and the mean age was 33.4 years. A 1.5T MR system (Philips) and a 47-mm microscopy surface coil were used. Axial sections of 2.0 mm thickness with a spacing of 0.2 mm were obtained by T1-weighted and T2-weighted fast spin echo and T2-weighted fast field echo. The field of view (F.O.V.) was 50 mm. We evaluated the cross-sectional area of the flexor tendons that included their surrounding flexor tendon synovium and the median nerve in both the finger-extended and finger-flexed positions. The structures in the carpal canal were clearly revealed on the MR images. The cross-sectional area of the flexor tendons, including the flexor tendon synovium, in patients was significantly enlarged in the finger-flexed position as compared with the finger-extended position. In the finger-flexed position, the median nerve was compressed in the radiovolar direction because of the enlarged flexor tendon synovium around the flexor digitorum profundus (FDP) tendons, which covered the entire ulnar side of the central carpal canal. In the control group, these changes were negligible. Therefore, we suggest that repeated mechanical stress of the flexor tendons with the thickening of the flexor tendon synovium can result in median nerve neuropathy. (author)

  11. Chromatographic finger print analysis of steroids in Aerva lanata L by HPTLC technique

    Yamunadevi Mariswamy; Wesely Edward Gnaraj; Johnson M

    2011-01-01

    Objective: To determine the chemical profile and steroids composition of the medicinally important plant Aerva lanata (A. lanata) L. Methods: Preliminary phytochemical screening was done by the method as Harborne described. HPTLC studies were carried out as Harborne and Wagner et al described. The Ethyl acetate-ethanol-water (8: 2: 1.2) was employed as mobile phase for glycosides. Results: The desired aim was achieved using Chloroform-acetone (8: 2) as the mobile phase. The methanolic extract of stem, leaves, root, flower and seeds of A. lanata showed the presence of 30 different types of steroids with 30 different Rf values from 0.04 to 0.97. Maximum number (11) of steroids has been observed in leaves followed by root (10). Conclusions:HPTLC profile of steroids has been chosen here to reveal the diversity existing in A. lanata. Such finger printing is useful in differentiating the species from the adulterant and act as biochemical markers for this medicinally important plant in the pharma industry and plant systematic studies.

  12. Cortical activity prior to, and during, observation and execution of sequential finger movements.

    Calmels, Claire; Holmes, Paul; Jarry, Gilbert; Lévèque, Jean-Michel; Hars, Magaly; Stam, Cornelis J

    2006-01-01

    The aim of this study was to provide further evidence for the existence of a mirror neuron system in humans using electroencephalography during the observation and execution of non-object-related movements. Event-related desynchronization and synchronization (ERD/ERS) were used to characterize brain activity prior to, and during, observation and execution of a finger movement in four frequency bands (7-10 Hz, 10-13 Hz, 13-20 Hz, and 20-30 Hz). Electroencephalograms (EEGs) were recorded from 19 electrode sites in eight participants. In all the frequency bands and electrode sites, results revealed that there was no significant differences in EEG cortical activity between the observation condition and the execution conditions. Comparison of the two stages of the movement (i.e., pre-movement and movement) in the observation and execution conditions showed, in most cases, that pre-movement ERD values were less than movement ERD values. Whilst there was not an identical match of EEG cortical indices, this study provides further support for the existence of a mirror neuron system in humans. The incomplete congruence may be explained by the different behaviors, the nature of the task and factors in the observed action coded by the mirror system. PMID:17136468

  13. Extrinsic and intrinsic index finger muscle attachments in an OpenSim upper-extremity model.

    Lee, Jong Hwa; Asakawa, Deanna S; Dennerlein, Jack T; Jindrich, Devin L

    2015-04-01

    Musculoskeletal models allow estimation of muscle function during complex tasks. We used objective methods to determine possible attachment locations for index finger muscles in an OpenSim upper-extremity model. Data-driven optimization algorithms, Simulated Annealing and Hook-Jeeves, estimated tendon locations crossing the metacarpophalangeal (MCP), proximal interphalangeal (PIP) and distal interphalangeal (DIP) joints by minimizing the difference between model-estimated and experimentally-measured moment arms. Sensitivity analysis revealed that multiple sets of muscle attachments with similar optimized moment arms are possible, requiring additional assumptions or data to select a single set of values. The most smooth muscle paths were assumed to be biologically reasonable. Estimated tendon attachments resulted in variance accounted for (VAF) between calculated moment arms and measured values of 78% for flex/extension and 81% for ab/adduction at the MCP joint. VAF averaged 67% at the PIP joint and 54% at the DIP joint. VAF values at PIP and DIP joints partially reflected the constant moment arms reported for muscles about these joints. However, all moment arm values found through optimization were non-linear and non-constant. Relationships between moment arms and joint angles were best described with quadratic equations for tendons at the PIP and DIP joints. PMID:25281408

  14. Finger Millet: A Potential Source For Production of Gluten Free Beer

    Ishrat Bano,

    2015-07-01

    Full Text Available Studies related to value addition of underutilized crops using fermentation technology need a radical approach. Present study has been made to explore the underutilized crops utilization for production of beer. Designed experiments were conducted to find the effect of three independent variables having three levels of each i.e. (blend ratio-80:20:0,80:10:10, 80:0:20 , α-amylase enzyme concentration - 0%, 0.4%, and 0.8% and slurry ratio -1:5, 1:7 and 1:9 on pH, colour and alcohol content of beer prepared from finger millet, barnyard millet and paddy. The data from all experiments were analyzed statistically using Design Expert 8.0.7.1 and the response functions were developed using the regression analysis. Result of fermented studies reveals that blend ratio had maximum effect on alcohol content,pH and colour but enzyme concentration had maximum effect on alcohol content while slurry ratio affected the colour of beer. Statistical analysis resulted in the optimum conditions of the independent variables as blend ratio (80:(9.6:(10.4, enzyme concentration 0.45% and slurry ratio 1:6.82 for maximum beer production. The second order model was found to be fitted to predict all the responses i.e., pH, colour and alcohol content.

  15. The Drosophila gene escargot encodes a zinc finger motif found in snail-related genes.

    Whiteley, M; Noguchi, P D; Sensabaugh, S M; Odenwald, W F; Kassis, J A

    1992-02-01

    Two independent P-element enhancer detection lines were obtained that express lacZ in a pattern of longitudinal stripes early in germband elongation. In this paper, molecular and genetic characterization of a gene located near these transposons is presented. Sequence analysis of a cDNA clone from the region reveals that this gene has a high degree of similarity with the Drosophila snail gene (Boulay et al., 1987). The sequence similarity extends over 400 nucleotides, and includes a region encoding five tandem zinc finger motifs (72% nucleotide identity; 76% amino acid identity). This region is also conserved in the snail homologue from Xenopus laevis (76% nucleotide identity; 83% amino acid identity) (Sargent and Bennett, 1990). We have named the Drosophila snail-related gene escargot (esg), and the region of sequence conservation common to all three genes the 'snailbox'. A number of Drosophila genomic DNA fragments cross-hybridize to a probe from the snailbox region suggesting that snail and escargot are members of a multigene family. The expression pattern of escargot is dynamic and complex. Early in germband elongation, escargot RNA is expressed in a pattern of longitudinal stripes identical to the one observed in the two enhancer detection lines. Later in development, escargot is expressed in cells that will form the larval imaginal tissues, escargot is allelic with l(2)35Ce, an essential gene located near snail in the genome. PMID:1571289

  16. Modifications of 'Gold Finger' Grape Berry Quality as Affected by the Different Rootstocks.

    Jin, Zhongxin; Sun, Hong; Sun, Tianyu; Wang, Qingjie; Yao, Yuxin

    2016-06-01

    Berry qualities of the grafted 'Gold Finger' grapevines were determined to evaluate the impacts of the resistant rootstocks on fruit quality. Compared to the own-rooted vines, berry and cluster weights and skin color were altered by the rootstocks to varying extents. The rootstock of 101-14M maintained TSS/TA and the contents of fructose, glucose, and sucrose, and SO4 decreased these parameters. 101-14M and 3309C increased and reduced the resveratrol content, respectively. SO4, 5BB, and 3309C decreased the total free amino acid content, along with the changes in amino acid composition. The amounts of aroma components were widely altered by the rootstocks. Additionally, a digital gene expression tag profiling revealed that the biological processes were largely altered by 3309C and 101-14M, including sugar, amino acid, and aroma metabolisms. In summary, the rootstock of 101-14M generally maintained berry quality, and SO4, 5BB, and 3309C imparted varying influences on different quality parameters. PMID:27088562

  17. Research Progress of PR Domain Zinc Finger Protein 14

    Yudong HAN

    2016-02-01

    Full Text Available PR domain zinc finger protein 14 (PRDM14 is an important member of the PRDM family, PRDM14 plays a key role in the maintenance of cell integrity and differentiation, growth and apoptosis of the cell. It also plays an critical role in the formation of primordial germ cells, the maintenance of the totipotency of stem cells and the formation of tissues and organs. PRDM14 bears a single PR domain and six tandemly repeated zinc fingers, which is involved in the process of the deacetylation and methylation of the histone, and is involved in the formation of tumor trough the change level of methylation in the promoter region. The abnormal methylation of PRDM14 can change the chromatin structure, DNA conformation and the interaction mode of DNA and protein, it can suppress transcription and expression of the gene, which caused the occurrence, development and metastasis of tumor. The research progress of PRDM14 is reviewed based on the relevant literatures published in China and abroad.

  18. Dopamine receptor regulating factor, DRRF: a zinc finger transcription factor.

    Hwang, C K; D'Souza, U M; Eisch, A J; Yajima, S; Lammers, C H; Yang, Y; Lee, S H; Kim, Y M; Nestler, E J; Mouradian, M M

    2001-06-19

    Dopamine receptor genes are under complex transcription control, determining their unique regional distribution in the brain. We describe here a zinc finger type transcription factor, designated dopamine receptor regulating factor (DRRF), which binds to GC and GT boxes in the D1A and D2 dopamine receptor promoters and effectively displaces Sp1 and Sp3 from these sequences. Consequently, DRRF can modulate the activity of these dopamine receptor promoters. Highest DRRF mRNA levels are found in brain with a specific regional distribution including olfactory bulb and tubercle, nucleus accumbens, striatum, hippocampus, amygdala, and frontal cortex. Many of these brain regions also express abundant levels of various dopamine receptors. In vivo, DRRF itself can be regulated by manipulations of dopaminergic transmission. Mice treated with drugs that increase extracellular striatal dopamine levels (cocaine), block dopamine receptors (haloperidol), or destroy dopamine terminals (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) show significant alterations in DRRF mRNA. The latter observations provide a basis for dopamine receptor regulation after these manipulations. We conclude that DRRF is important for modulating dopaminergic transmission in the brain. PMID:11390978

  19. Inherited epidermolysis bullosa: Case report of finger localization

    Anne- Aurore Sankale

    2012-01-01

    Full Text Available Inherited epidermolysis bullosa is a rare condition that often present at birth with skin blisters and erosions. They are associated with defective cohesion of the dermis and epidermis. There are 3 principal types: Simple, junctional and dystrophic. The severity of the condition is quite variable. The most severe forms are incompatible with life. The most common types in our country are the severe ones such as the Hallopeau -Siemens subtype. Hands and mucosal areas can develop synechia. We report here a case of dystrophic epidermolysis bullosa in a 27-year-old woman whose finger lesion was managed surgically. This treatment consisted of complete removal of constrictions and adhesions, accompanied by use of a Hueston flap and skin graft to repair the tissue deficit. The patient′s clinical course required several repeat operations. This surgery allowed the possible total loss of hand function to be delayed but the inevitable progression of the illness made the treatment somewhat disappointing. Psychosocial implications are very significant in our setting.

  20. Osteoclastic finger arthrosis - a subtype of polyarthrosis of the hand

    Aim: Description of a subtype of arthrosis deformans of the hand which is characterised as osteoclastic arthrosis. Patients and methods: Retrospective analysis of radiographs of the hands of 150 women and 100 men with radiological findings of arthrosis deformans. Results: 5% of women and 2% of men showed at least one digital joint with subchondral osteolysis of one or both articulating bones involving at least a third of the phalanx. This subchondral osteolysis far exceeds the cysts which are situated in the epiphyseal part of the articular region. It may develop within a year. Conclusion: Osteoclastic arthrosis of the finger is a subtype of polyarthrosis of the hand. Serial observations suggest that an osteoclast stimulating substance is produced by the cysts or arises directly from the synovial fluid; this enters the subchondral part of the bone through clefts which may or may not be visible radiologically and that this produces osteoclastic activity. The most important differential diagnoses are chronic tophacious gout and a benign tumor. (orig.)

  1. Two IPMC Fingers Based Micro Gripper For Handling

    R K Jain

    2011-03-01

    Full Text Available This paper presents the behavior of two finger based micro gripper which is made of Ionic Polymer Metal Composite (IPMC, an Electro Active Polymer (EAP. An IPMC shows great potential as high-displacement and light weight actuator. Low mass force generation capability is utilized for micro gripping in micro assembly. IPMC responds to low voltage in the range of 0-3V. The material contains an electrolyte which transport ions in response to an external electric field. IPMC actuation for micro gripping is produced by deflecting material according to bending moment theory. An external electric field generated by suitable RC circuit causes this deflection. It is found that an IPMC actuates from 1-5 seconds. The maximum jaw opening and closing position of micro gripper are found to be 5 mm and 0.5 mm respectively. The effect of tempearture, as observed, shows that the acceptable limit varies from 23.10C to 30.40C while an IPMC is in operation. An experimental proto type is developed for evaluation of performance.

  2. Kick with the finger: symbolic actions shape motor cortex excitability.

    Betti, Sonia; Castiello, Umberto; Sartori, Luisa

    2015-11-01

    A large body of research indicates that observing actions made by others is associated with corresponding motor facilitation of the observer's corticospinal system. However, it is still controversial whether this matching mechanism strictly reflects the kinematics of the observed action or its meaning. To test this issue, motor evoked potentials induced by single-pulse transcranial magnetic stimulation were recorded from hand and leg muscles while participants observed a symbolic action carried out with the index finger, but classically performed with the leg (i.e., a soccer penalty kick). A control condition in which participants observed a similar (but not symbolic) hand movement was also included. Results showed that motor facilitation occurs both in the observer's hand (first dorsal interosseous) and leg (quadriceps femoris) muscles. The present study provides evidence that both the kinematics and the symbolic value of an observed action are able to modulate motor cortex excitability. The human motor system is thus not only involved in mirroring observed actions but is also finely tuned to their symbolic value. PMID:26354677

  3. COMPUTER SIMULATION OF VISCOUS FINGERING IN SIERPINSKI CARPET

    1998-01-01

    A new method - mapping dilation method is proposed in this paper to construct Sierpinski carpet. Viscous fingering (VF) in Sierpinski carpet, based on the assumption that bond radii are beta distribution, is investigated by means of successive over-relaxation techniques. The topology and the geometry of the porous media have a strong effect on displacement processes. In the Sierpinski network, the VF pattern of porous media in the limit M →∞ is found to be similar to the diffusion-limited-aggregation pattern. The fractal dimension for VF in fractal space is calculated and the fractal dimension D can be reasonably regarded as a useful parameter to evaluate the sweep efficiencies and oil recoveries. We have also found that the geometry of the porous medium also has strong effects on the displacement processes and the structure of the VF. Moreover, we find that the sweep efficiency of the displacement processes mainly depends upon the length of the network system and also on the viscosity ratio M. This shows that the current method can be used to solve VF problems in complex structures if the structures are self-similar, or they can be reduced to a self-similar structure.

  4. Recurring fingered flow pathways in a water repellent sandy field soil

    Ritsema, C. J.; Dekker, L. W.; van den Elsen, E. G. M.; Oostindiel, K.; Steenhuis, T. S.; Nieber, J. L.

    Field evidence of finger formation and reformation during Successive rain events over an eight months' observation period from June 1994 until January 1995 is presented. Fingered flow pathways were monitored in a no-tilled, grass-covered water repellent sandy field soil using an automated, stand-alone TDR device. Within a 2 m long and 0.7 m deep transect, 98 three-wire probes were installed horizontally at depths of 4, 12, 20, 30, 40, 55, and 70 cm. The horizontal distance between two adjacent probes was IS cm. Finger formation occurred during distinct rainy periods and was most pronounced under heavy rainfall with initially wet topsoil conditions. The percentage of water infiltrated and transported preferentially through the fingers to the deep subsoil varied between 0 and 80%, depending on the wetting history of the soil and the rainfall characteristics.

  5. Determining the number of fingers in the lifting Hele-Shaw problem

    Miranda, Jose; Dias, Eduardo

    2013-11-01

    The lifting Hele-Shaw cell flow is a variation of the celebrated radial viscous fingering problem for which the upper cell plate is lifted uniformly at a specified rate. This procedure causes the formation of intricate interfacial patterns. Most theoretical studies determine the total number of emerging fingers by maximizing the linear growth rate, but this generates discrepancies between theory and experiments. In this work, we tackle the number of fingers selection problem in the lifting Hele-Shaw cell by employing the recently proposed maximum-amplitude criterion. Our linear stability analysis accounts for the action of capillary, viscous normal stresses, and wetting effects, as well as the cell confinement. The comparison of our results with very precise laboratory measurements for the total number of fingers shows a significantly improved agreement between theoretical predictions and experimental data. We thank CNPq (Brazilian Sponsor) for financial support.

  6. RETRACTED ARTICLE: Nutritional, technological, and medical approach of finger millet (Eleusine coracana

    Amir Gull

    2015-12-01

    Full Text Available Finger millet (Eleusine coracana L. is also known as African millet and is commonly called “ragi” in India. It has excellent nutritional value and is even superior to other common cereals. It is a richest source of calcium (344 mg and magnesium (408 mg than other millets. Predominant fatty acids of this millet are oleic (49%, linoleic (25%, and palmitic acids (25%. Finger millet contains both water-soluble and lipo-soluble vitamins. Emerging bakery products prepared from this millet are pasta, noodles, vermicelli, and bread. Being gluten free, it is suitable for individuals suffering from celiac disease. Finger millet grain is a rich source of several phytochemicals. Finger millet possesses blood glucose lowering, cholesterol lowering, and antiulcerative, wound healing properties as indicated by in vitro and in vivo studies. Commonly used processing techniques for this millet are milling, malting, popping, and decortications.

  7. Patient-Specific Prosthetic Fingers by Remote Collaboration - A Case Study

    Cabibihan, John-John

    2011-01-01

    The concealment of amputation through prosthesis usage can shield an amputee from social stigma and help improve the emotional healing process especially at the early stages of hand or finger loss. However, the traditional techniques in prosthesis fabrication defy this as the patients need numerous visits to the clinics for measurements, fitting and follow-ups. This paper presents a method for constructing a prosthetic finger through online collaboration with the designer. The main input from the amputee comes from the Computer Tomography (CT) data in the region of the affected and the non-affected fingers. These data are sent over the internet and the prosthesis is constructed using visualization, computer-aided design and manufacturing tools. The finished product is then shipped to the patient. A case study with a single patient having an amputated ring finger at the proximal interphalangeal joint shows that the proposed method has a potential to address the patient's psychosocial concerns and minimize the ...

  8. A Hybrid Model for Biometric Authentication using Finger Back Knuckle Surface based on Angular Geometric Analysis

    K.Usha

    2013-08-01

    Full Text Available Biometric based personal recognition is an efficient method for identifying a person. Recently, hand based biometric has become popular due to its various advantages such as high verification accuracy and high user acceptability. This paper proposes a hybrid model using an emerging hand based biometric trait known as Finger Back Knuckle Surface. This model is based on angular geometric analysis which is implemented on two different samples of Finger Back Knuckle Surface such as Finger Bend Knuckle Surface and Finger Intact Knuckle Surface for the extraction of knuckle feature information. The obtained feature information from both the surfaces is fused using feature information level fusion technique to authenticate the individuals. Experiments were conducted using newly created database for both Bend Knuckle and Intact Knuckle Surface. The results were promising in terms of accuracy, speed and computational complexity.

  9. In Vivo Finger Flexor Tendon Force while Tapping on a Keyswitch

    Dennerlein, Jack Tigh; Diao, Edward; Mote, C. D.; Rempel, David M.

    1999-01-01

    Force may be a risk factor for musculoskeletal disorders of the upper extremity associated with typing and keying. However, the internal finger flexor tendon forces and their relationship to fingertip forces during rapid tapping on a keyswitch have not yet been measured in vivo. During the open carpal tunnel release surgery of five human subjects, a tendon-force transducer was inserted on the flexor digitorum super-ficialis of the long finger. During surgery, subjects tapped with the long fin...

  10. Balancing tension in transferred slips in some dynamic procedures for claw finger correction

    Malaviya G

    2005-01-01

    The adjustment of tension on the tendon slips which are being inserted to correct finger clawing, is the critical step in claw finger correction procedures. Several methods have been described in literature but ultimately every thing boils down to the experience of the operating surgeon who has to make decisions on the operating table. Attempt is being made to translate this experience (an abstract noun) in to words to help make life easier for the surgeons who are venturing into the field of...

  11. Investigation of the Reliability of the Blood Markers in Human Identity Recognition by DNA Finger Printing

    Morteza Sadeghi; Alireza Sabouri

    2014-01-01

    Introduction: Determination of blood groups is the first step in the approval or rejection of blood relation between the two individuals for identity recognition. The aim of this study is to investigate the reliability of common blood grouping systems in DNA finger printing recognition. Methods: In this study, blood samples were obtained from 300 individuals belonging to 150 families. Then, DNA of each individual was purified and DNA finger printing was performed for 10 STR regions using A...

  12. Modified indirect hemagglutination test for detection of treponemal antibodies in finger-prick blood.

    Backhouse, J L; Lee, M. H.; Nesteroff, S I; Hudson, B J; Hamilton, P. A.

    1992-01-01

    A modified indirect hemagglutination test for the detection of treponemal antibodies was developed for use with finger-prick blood. By using paired serum and absorbed finger-prick blood from 58 patients from an area previously endemic for yaws and 12 patients without yaws, the modified hemagglutination test was compared with a hemagglutination test for Treponema pallidum and the fluorescent treponemal antibody absorption test. The modified hemagglutination test showed 100% specificity and an ...

  13. Rapid Mutation of Endogenous Zebrafish Genes Using Zinc Finger Nucleases Made by Oligomerized Pool ENgineering (OPEN)

    Foley, Jonathan E.; Reyon, Deepak; Yeh, Jing-Ruey Joanna; Maeder, Morgan L.; Sander, Jeffry D.; Peterson, Randall Theodore; Joung, Jae Keith

    2009-01-01

    Background: Customized zinc finger nucleases (ZFNs) form the basis of a broadly applicable tool for highly efficient genome modification. ZFNs are artificial restriction endonucleases consisting of a non-specific nuclease domain fused to a zinc finger array which can be engineered to recognize specific DNA sequences of interest. Recent proof-of-principle experiments have shown that targeted knockout mutations can be efficiently generated in endogenous zebrafish genes via non-homologous end-jo...

  14. Metal Coupled Folding of Cys2His2 Zinc-Finger

    Li, Wenfei; Zhang, Jian; Wang, Jun; Wang, Wei

    2008-01-01

    Zinc-fingers, which widely exist in eukaryotic cell and play crucial roles in life processes, depend on the binding of zinc ion for their proper folding. To computationally study the zinc coupled folding of the zinc-fingers, charge transfer and metal induced protonation/deprotonation effects have to be considered. Here, by attempting to implicitly account for such effects in classical molecular dynamics and performing intensive simulations with explicit solvent for the peptides with and witho...

  15. Finger Muscle Attachments for an OpenSim Upper-Extremity Model

    Lee, Jong Hwa; Asakawa, Deanna S.; Dennerlein, Jack T.; Jindrich, Devin L.

    2015-01-01

    We determined muscle attachment points for the index, middle, ring and little fingers in an OpenSim upper-extremity model. Attachment points were selected to match both experimentally measured locations and mechanical function (moment arms). Although experimental measurements of finger muscle attachments have been made, models differ from specimens in many respects such as bone segment ratio, joint kinematics and coordinate system. Likewise, moment arms are not available for all intrinsic fin...

  16. Divergent dislocation of the ring and little finger carpometacarpal joints--a rare injury pattern.

    Dillon, John

    2012-02-03

    Hand injuries due to longitudinal forces in the line of the metacarpals demonstrate unusual dislocation patterns. We describe a case of volar intra-articular fracture dislocation of the ring finger carpometacarpal joint in association with a pure dorsal dislocation of the little finger carpometacarpal joint. Open reduction supplemented with Kirschner wire fixation restored normal carpometacarpal joint anatomical relations and achieved an excellent clinical result.

  17. Simulated Microbe Removal around Finger Rings Using Different Hand Sanitation Methods

    Alur, Archana A; Rane, Madhavi J.; Scheetz, James P.; Lorenz, Douglas J.; Gettleman, Lawrence

    2009-01-01

    Aim It is our opinion that the CDC and the WHO have underestimated cross-contamination under examination gloves in dental clinics while wearing jewelry, such as finger rings. These agencies only “recommend” removing jewelry, and only washing hands for 15 seconds with soap and warm water before donning gloves. This study examined several washing procedures and finger rings using simulated microbes. Methodology A gloved rubber hand manikin was made and fitted with a fresh disposable vinyl glove...

  18. Biased Wrist and Finger Coordination in Parkinsonian Patients during Performance of Graphical Tasks

    Dounskaia, Natalia; Van Gemmert, Arend W.A.; Leis, Berta C; Stelmach, George E.

    2009-01-01

    Handwriting impairments in Parkinson’s disease (PD) have been associated with micrographia, i.e. diminished letter size. However, dyscoordination of the wrist and fingers may also contribute to handwriting deterioration in PD. To investigate this hypothesis, right-handed PD patients and controls were tested in performance of three types of cyclic wrist and finger movements: drawing of two lines and a circle. The line drawing was performed with either simultaneous flexion and extension of the ...

  19. Single trial discrimination of individual finger movements on one hand: A combined MEG and EEG study☆

    Quandt, F.; Reichert, C.; Hinrichs, H.; Heinze, H J; Knight, R. T.; Rieger, J W

    2011-01-01

    It is crucial to understand what brain signals can be decoded from single trials with different recording techniques for the development of Brain-Machine Interfaces. A specific challenge for non-invasive recording methods are activations confined to small spatial areas on the cortex such as the finger representation of one hand. Here we study the information content of single trial brain activity in non-invasive MEG and EEG recordings elicited by finger movements of one hand. We investigate t...

  20. Women's finger sensitivity correlates with partnered sexual behavior but not solitary masturbation frequencies.

    Brody, Stuart; Fischer, Agneta H; Hess, Ursula

    2008-01-01

    In a sample of 97 healthy Dutch female university students, women with greater finger tactile sensitivity (von Frey-type filaments) engaged more in partnered (but not solitary masturbation) sexual behavior. Orgasmic responses in the past 30 days were not correlated with finger sensitivity. Results are discussed in terms of differences between different sexual behaviors, as well as susceptibility to reinforcement, and psychoanalytic views of conversion hysteria. PMID:18576235

  1. Computer-aided joint space analysis of the metacarpal-phalangeal and proximal-interphalangeal finger joint: normative age-related and gender-specific data

    Pfeil, Alexander; Boettcher, Joachim; Seidl, Bettina E.; Heyne, Jens-Peter; Petrovitch, Alexander; Mentzel, Hans-Joachim; Kaiser, Werner A. [Friedrich-Schiller-University Jena, Institute of Diagnostic and Interventional Radiology, Jena (Germany); Eidner, Torsten; Wolf, Gunter; Hein, Gert [Friedrich-Schiller-University Jena, Department of Rheumatology and Osteology, Clinic of Internal Medicine III, Jena (Germany)

    2007-09-15

    The purpose of the study was to provide reference data for computer-aided joint space analysis based on a semi-automated and computer-aided diagnostic system for the measurement of metacarpal-phalangeal and proximal-interphalangeal finger joint widths; additionally, the determination of sex differences and the investigation of changes in joint width with age were evaluated. Eighty hundred and sixty-nine patients (351 female and 518 male) received radiographs of the hand for trauma and were screened for a host of conditions known to affect the joint spaces. All participants underwent measurements of joint space distances at the metacarpal-phalangeal articulation (JSD-MCP) from the thumb to the small finger and at the proximal-interphalangeal articulation (JSD-PIP) from the index finger to the small finger using computer-aided diagnosis technology with semi-automated edge detection. The study revealed an annual narrowing of the JSD of 0.6% for the JSD-MCP and for the JSD-PIP. Furthermore, the data demonstrated a notable age-related decrease in JSD, including an accentuated age-related joint space narrowing in women for both articulations. Additionally, males showed a significantly wider JSD-MCP (+11.1%) and JSD-PIP (+15.4%) compared with the female cohort in all age groups. Our data presented gender-specific and age-related normative reference values for computer-aided joint space analysis of the JSD-MCP and JSD-PIP that could be used to identify disease-related joint space narrowing, particularly in patients with osteoarthritis and rheumatoid arthritis commonly involving the peripheral small hand joints. (orig.)

  2. Ribosomal protein uS19 mutants reveal its role in coordinating ribosome structure and function.

    Bowen, Alicia M; Musalgaonkar, Sharmishtha; Moomau, Christine A; Gulay, Suna P; Mirvis, Mary; Dinman, Jonathan D

    2015-01-01

    Prior studies identified allosteric information pathways connecting functional centers in the large ribosomal subunit to the decoding center in the small subunit through the B1a and B1b/c intersubunit bridges in yeast. In prokaryotes a single SSU protein, uS13, partners with H38 (the A-site finger) and uL5 to form the B1a and B1b/c bridges respectively. In eukaryotes, the SSU component was split into 2 separate proteins during the course of evolution. One, also known as uS13, participates in B1b/c bridge with uL5 in eukaryotes. The other, called uS19 is the SSU partner in the B1a bridge with H38. Here, polyalanine mutants of uS19 involved in the uS19/uS13 and the uS19/H38 interfaces were used to elucidate the important amino acid residues involved in these intersubunit communication pathways. Two key clusters of amino acids were identified: one located at the junction between uS19 and uS13, and a second that appears to interact with the distal tip of H38. Biochemical analyses reveal that these mutations shift the ribosomal rotational equilibrium toward the unrotated state, increasing ribosomal affinity for tRNAs in the P-site and for ternary complex in the A-site, and inhibit binding of the translocase, eEF2. These defects in turn affect specific aspects of translational fidelity. These findings suggest that uS19 plays a critical role as a conduit of information exchange between the large and small ribosomal subunits directly through the B1a, and indirectly through the B1b/c bridges. PMID:26824029

  3. Revealing Rembrandt

    Andrew J Parker

    2014-04-01

    Full Text Available The power and significance of artwork in shaping human cognition is self-evident. The starting point for our empirical investigations is the view that the task of neuroscience is to integrate itself with other forms of knowledge, rather than to seek to supplant them. In our recent work, we examined a particular aspect of the appreciation of artwork using present-day functional magnetic resonance imaging (fMRI. Our results emphasised the continuity between viewing artwork and other human cognitive activities. We also showed that appreciation of a particular aspect of artwork, namely authenticity, depends upon the co-ordinated activity between the brain regions involved in multiple decision making and those responsible for processing visual information. The findings about brain function probably have no specific consequences for understanding how people respond to the art of Rembrandt in comparison with their response to other artworks. However, the use of images of Rembrandt’s portraits, his most intimate and personal works, clearly had a significant impact upon our viewers, even though they have been spatially confined to the interior of an MRI scanner at the time of viewing. Neuroscientific studies of humans viewing artwork have the capacity to reveal the diversity of human cognitive responses that may be induced by external advice or context as people view artwork in a variety of frameworks and settings.

  4. Analysis of a 12-Finger Rod Drop using RETRAN/MASTER Code System for APR1400

    The Optimized Power Reactor 1000 (OPR1000) has 4-finger and 12-finger Control Element Assemblies (CEAs). When the 12-finger CEA is dropped, Core Protection Calculator System (CPCS) shuts down the reactor to prevent fuel damage that could occur from the sudden reactor power peaking. By contrast, the improved CPCS of Advanced Power Reactor 1400 (APR1400), which has systems similar to those of the OPR1000, decreases reactor power rapidly using its Reactor Power Cutback System (RPCS) to avoid unwanted reactor trips caused by the CPCS during a 12- finger CEA drop event. RETRAN is a best-estimate code for transient analysis of Non-LOCA. The RETRAN control logic, which includes the function of reducing reactor power during a 12-Finger CEA drop, has been developed for the APR1400. A MATRAN program has also been developed. MATRAN is the interface program for realtime processing to connect RETRAN with MASTER code which is a nuclear analysis and design code. MATRAN supplies adequate feedback reactivities from the MASTER code to RETRAN code. The purpose of this study is to analyze the behavior of a nuclear reactor core and its primary system using conventional RETRAN analysis procedure and MATRAN program analysis procedure during a 12- finger CEA drop. In addition, the axial power distribution and Axial Shape Index (ASI) are produced by the MATRAN program and they are confirmed as within operation limits

  5. Rate effects on timing, key velocity, and finger kinematics in piano performance.

    Bella, Simone Dalla; Palmer, Caroline

    2011-01-01

    We examined the effect of rate on finger kinematics in goal-directed actions of pianists. In addition, we evaluated whether movement kinematics can be treated as an indicator of personal identity. Pianists' finger movements were recorded with a motion capture system while they performed melodies from memory at different rates. Pianists' peak finger heights above the keys preceding keystrokes increased as tempo increased, and were attained about one tone before keypress. These rate effects were not simply due to a strategy to increase key velocity (associated with tone intensity) of the corresponding keystroke. Greater finger heights may compensate via greater tactile feedback for a speed-accuracy tradeoff that underlies the tendency toward larger temporal variability at faster tempi. This would allow pianists to maintain high temporal accuracy when playing at fast rates. In addition, finger velocity and accelerations as pianists' fingers approached keys were sufficiently unique to allow pianists' identification with a neural-network classifier. Classification success was higher in pianists with more extensive musical training. Pianists' movement "signatures" may reflect unique goal-directed movement kinematic patterns, leading to individualistic sound. PMID:21731615

  6. Rate effects on timing, key velocity, and finger kinematics in piano performance.

    Simone Dalla Bella

    Full Text Available We examined the effect of rate on finger kinematics in goal-directed actions of pianists. In addition, we evaluated whether movement kinematics can be treated as an indicator of personal identity. Pianists' finger movements were recorded with a motion capture system while they performed melodies from memory at different rates. Pianists' peak finger heights above the keys preceding keystrokes increased as tempo increased, and were attained about one tone before keypress. These rate effects were not simply due to a strategy to increase key velocity (associated with tone intensity of the corresponding keystroke. Greater finger heights may compensate via greater tactile feedback for a speed-accuracy tradeoff that underlies the tendency toward larger temporal variability at faster tempi. This would allow pianists to maintain high temporal accuracy when playing at fast rates. In addition, finger velocity and accelerations as pianists' fingers approached keys were sufficiently unique to allow pianists' identification with a neural-network classifier. Classification success was higher in pianists with more extensive musical training. Pianists' movement "signatures" may reflect unique goal-directed movement kinematic patterns, leading to individualistic sound.

  7. Use of preputial skin for coverage of post-burn contractures of fingers in children

    Mohammed I Zaroo

    2011-01-01

    Full Text Available Objective: Hand burns are common injuries. Children frequently sustain burn injuries, especially to their hands. Contractures are a common sequel of severe burns around joints. The prepuce, or foreskin, has been used as a skin graft for a number of indications. We conducted this study to evaluate the feasibility of utilising the preputial skin for the management of post-burn contractures of fingers in uncircumcised male children. Materials and Methods: Preputial skin was used for the coverage of released contractures of fingers in 12 patients aged 2-6 years. The aetiology of burns was "Kangri" burn in eight patients and scalding in four patients. Six patients had contracture in two fingers, four patients in one finger, and two patients had contractures in three fingers. Results: None of the patients had graft loss, and all the wounds healed within 2 weeks. All patients had complete release of contractures without any recurrence. Hyperpigmentation of the grafts was observed over a period of time, which was well accepted by the parents. Conclusions: Preputial skin can be used successfully for male children with mild-to-moderate contractures of 2-3 fingers for restoration of the hand function, minimal donor site morbidity.

  8. Non-destructive examination of the bonding interface in DEMO divertor fingers

    Highlights: • SATIR tests on DEMO divertor fingers (integrating or not He cooling system). • Millimeter size artificial defects were manufactured. • Detectability of millimeter size artificial defects was evaluated. • SATIR can detect defect in DEMO divertor fingers. • Simulations are well correlated to SATIR tests. -- Abstract: Plasma facing components (PFCs) with tungsten (W) armor materials for DEMO divertor require a high heat flux removal capability (at least 10 MW/m2 in steady-state conditions). The reference divertor PFC concept is a finger with a tungsten tile as a protection and sacrificial layer brazed to a thimble made of tungsten alloy W – 1% La2O3 (WL10). Defects may be located at the W thimble to W tile interface. As the number of fingers is considerable (>250,000), it is then a major issue to develop a reliable control procedure in order to control with a non-destructive examination the fabrication processes. The feasibility for detecting defect with infrared thermography SATIR test bed is presented. SATIR is based on the heat transient method and is used as an inspection tool in order to assess component heat transfer capability. SATIR tests were performed on fingers integrating or not the complex He cooling system (steel cartridge with jet holes). Millimeter size artificial defects were manufactured and their detectability was evaluated. Results of this study demonstrate that the SATIR method can be considered as a relevant non-destructive technique examination for the defect detection of DEMO divertor fingers

  9. Median nerve deformation and displacement in the carpal tunnel during index finger and thumb motion.

    van Doesburg, Margriet H M; Yoshii, Yuichi; Villarraga, Hector R; Henderson, Jacqueline; Cha, Stephen S; An, Kai-Nan; Amadio, Peter C

    2010-10-01

    The purpose of this study was to investigate the deformation and displacement of the normal median nerve in the carpal tunnel during index finger and thumb motion, using ultrasound. Thirty wrists from 15 asymptomatic volunteers were evaluated. Cross-sectional images during motion from full extension to flexion of the index finger and thumb were recorded. On the initial and final frames, the median nerve, flexor pollicis longus (FPL), and index finger flexor digitorum superficialis (FDS) tendons were outlined. Coordinate data were recorded and median nerve cross-sectional area, perimeter, aspect ratio of the minimal-enclosing rectangle, and circularity in extension and flexion positions were calculated. During index finger flexion, the tendon moves volarly while the nerve moves radially. With thumb flexion, the tendon moves volarly, but the median nerve moves toward the ulnar side. In both motions, the area and perimeter of the median nerve in flexion were smaller than in extension. Thus, during index finger or thumb flexion, the median nerve in a healthy human subject shifts away from the index finger FDS and FPL tendons while being compressed between the tendons and the flexor retinaculum in the carpal tunnel. We are planning to compare these data with measurements in patients with carpal tunnel syndrome (CTS) and believe that these parameters may be useful tools for the assessment of CTS and carpal tunnel mechanics with ultrasound in the future. PMID:20225286

  10. Decoding finger movements from ECoG signals using switching linear models

    Remi eFlamary

    2012-03-01

    Full Text Available One of the most interesting challenges in ECoG-based Brain-Machine Interface is movement prediction. Being able to perform such a prediction paves the way to high-degree precision command for a machine such as a robotic arm or robotic hands. As a witness of the BCI community increasing interest towards such a problem, the fourth BCI Competition provides a dataset which aim is to predict individual finger movements from ECog signals. The difficulty of the problem relies on the fact that there is no simple relation between ECoG signals and finger movements. We propose in this paper, to estimate and decode these finger flexions using switching models controlled by an hidden state. Switching models can integrate prior knowledge about the decoding problem and helps in predicting fine and precise movements. Our model is thus based on a first block which estimates which finger is moving and anotherblock which, knowing which finger is moving, predicts the movements of allother fingers. Numerical results that have been submitted to the Competition show that the model yields high decoding performances when the hidden state is well estimated. This approach achieved the second place in the BCI competition with a correlation measure between real and predictedmovements of 0.42.

  11. Design of a Reconfigurable Robotic System for Flexoextension Fitted to Hand Fingers Size

    Castillo-Castaneda, Eduardo

    2016-01-01

    Due to the growing demand for assistance in rehabilitation therapies for hand movements, a robotic system is proposed to mobilize the hand fingers in flexion and extension exercises. The robotic system is composed by four, type slider-crank, mechanisms that have the ability to fit the user fingers length from the index to the little finger, through the adjustment of only one link for each mechanism. The trajectory developed by each mechanism corresponds to the natural flexoextension path of each finger. The amplitude of the rotations for metacarpophalangeal joint (MCP) and proximal interphalangeal joint (PIP) varies from 0 to 90° and the distal interphalangeal joint (DIP) varies from 0 to 60°; the joint rotations are coordinated naturally. The four R-RRT mechanisms orientation allows a 15° abduction movement for index, ring, and little fingers. The kinematic analysis of this mechanism was developed in order to assure that the displacement speed and smooth acceleration into the desired range of motion and the simulation results are presented. The reconfiguration of mechanisms covers about 95% of hand sizes of a group of Mexican adult population. Maximum trajectory tracking error is less than 3% in full range of movement and it can be compensated by the additional rotation of finger joints without injury to the user. PMID:27524880

  12. Design of a Reconfigurable Robotic System for Flexoextension Fitted to Hand Fingers Size

    J. Felipe Aguilar-Pereyra

    2016-01-01

    Full Text Available Due to the growing demand for assistance in rehabilitation therapies for hand movements, a robotic system is proposed to mobilize the hand fingers in flexion and extension exercises. The robotic system is composed by four, type slider-crank, mechanisms that have the ability to fit the user fingers length from the index to the little finger, through the adjustment of only one link for each mechanism. The trajectory developed by each mechanism corresponds to the natural flexoextension path of each finger. The amplitude of the rotations for metacarpophalangeal joint (MCP and proximal interphalangeal joint (PIP varies from 0 to 90° and the distal interphalangeal joint (DIP varies from 0 to 60°; the joint rotations are coordinated naturally. The four R-RRT mechanisms orientation allows a 15° abduction movement for index, ring, and little fingers. The kinematic analysis of this mechanism was developed in order to assure that the displacement speed and smooth acceleration into the desired range of motion and the simulation results are presented. The reconfiguration of mechanisms covers about 95% of hand sizes of a group of Mexican adult population. Maximum trajectory tracking error is less than 3% in full range of movement and it can be compensated by the additional rotation of finger joints without injury to the user.

  13. Design of a Reconfigurable Robotic System for Flexoextension Fitted to Hand Fingers Size.

    Aguilar-Pereyra, J Felipe; Castillo-Castaneda, Eduardo

    2016-01-01

    Due to the growing demand for assistance in rehabilitation therapies for hand movements, a robotic system is proposed to mobilize the hand fingers in flexion and extension exercises. The robotic system is composed by four, type slider-crank, mechanisms that have the ability to fit the user fingers length from the index to the little finger, through the adjustment of only one link for each mechanism. The trajectory developed by each mechanism corresponds to the natural flexoextension path of each finger. The amplitude of the rotations for metacarpophalangeal joint (MCP) and proximal interphalangeal joint (PIP) varies from 0 to 90° and the distal interphalangeal joint (DIP) varies from 0 to 60°; the joint rotations are coordinated naturally. The four R-RRT mechanisms orientation allows a 15° abduction movement for index, ring, and little fingers. The kinematic analysis of this mechanism was developed in order to assure that the displacement speed and smooth acceleration into the desired range of motion and the simulation results are presented. The reconfiguration of mechanisms covers about 95% of hand sizes of a group of Mexican adult population. Maximum trajectory tracking error is less than 3% in full range of movement and it can be compensated by the additional rotation of finger joints without injury to the user. PMID:27524880

  14. The Zn-finger domain of RIZ protein promotes MCF-7 cell proliferation.

    Rossi, Mariangela; Abbondanza, Ciro; D'Arcangelo, Andrea; Gazzerro, Patrizia; Medici, Nicola; Moncharmont, Bruno; Puca, Giovanni Alfredo

    2004-11-25

    In order to understand the oncogenic properties of retinoblastoma-interacting zinc-finger (RIZ) gene products, we produced an MCF-7-derived cell line expressing a fusion protein containing the zinc-finger (aa 359-497) domain of RIZ protein (MCF-7/znf). The Zn-finger domain contains three of the eight putative Zn-finger motifs and is located in proximity of the E1A-like domain containing the Rb protein-binding motif. The MCF-7/znf cells showed a higher growth rate than the parental or the control cell lines, both in hormone-deprived conditions or upon estrogen stimulation. Furthermore, they were less sensitive to the growth inhibitory effect of anti-estrogens and showed a higher level of expression of cyclin D1 and A. The expressed Zn-finger domain recombinant product was localized in the nucleus and in the nucleoli and its expression modified the pattern of actin staining in the cytoplasm. In conclusion the presented results indicated that the Zn-finger domain could be endowed with the putative oncogenic activity of RIZ2 gene product. PMID:15488642

  15. The anthropomorphic design and experiments of HIT/DLR five-fingered dexterous hand

    Fan Shaowei; Liu Yiwei; Jin Minghe; Lan Tian; Liu Hong

    2009-01-01

    This paper presents a new developed anthropomorphic robot dexterous hand: HIT/DLR Hand II. The hand is composed of an independent palm and five identical modular fingers, and each finger has three degree of freedom (DOFs) and four joints. All the actuators and electronics are integrated in the finger body and the palm. Owing to using a new actuator, drivers and a novel arrangement, both the length and width of the finger is about two third of its former version. By using the wire coupling mechanism, the distal phalanx transmission ratio is kept exactly 1:1 in the whole movement range. The packing mechanism which is implemented directly in the finger body and palm not only reduces the size of whole hand but also make it more anthropomorphic. Additionally, the new designed force/torque and position sensors are integrated in the hand for increasing multisensory capability. To evaluate the performances of the finger mechanism, the position and impedance control experiments are conducted.

  16. The Role of Cdkn1A-Interacting Zinc Finger Protein 1 (CIZ1 in DNA Replication and Pathophysiology

    Qiang Liu

    2016-02-01

    Full Text Available Cdkn1A-interacting zinc finger protein 1 (CIZ1 was first identified in a yeast-2-hybrid system searching for interacting proteins of CDK2 inhibitor p21Cip1/Waf1. Ciz1 also binds to CDK2, cyclin A, cyclin E, CDC6, PCNA, TCF4 and estrogen receptor-α. Recent studies reveal numerous biological functions of CIZ1 in DNA replication, cell proliferation, and differentiation. In addition, splicing variants of CIZ1 mRNA is associated with a variety of cancers and Alzheimer’s disease, and mutations of the CIZ1 gene lead to cervical dystonia. CIZ1 expression is increased in cancers and rheumatoid arthritis. In this review, we will summarize the biological functions and molecular mechanisms of CIZ1 in these physiological and pathological processes.

  17. Sequence and characterisation of the Z gene encoding ring finger protein of the lymphocytic choriomeningitis virus MX strain

    We have cloned and characterised a cDNA encoding Z protein of recently identified MX strain of Iymphocytic choriomeningitis virus (LCMV) persistently infecting human MaTu cells. Deduced amino acid sequence of LCMV MX Z protein showed 88.9% identity with that of the LCMV Armstrong (ARM) strain and 80.9% identity with that of the LCMV Traub (TRA) strain. It contained conserved zinc- binding RING finger domain and C-terminal proline-rich region. Northern blot analysis of total RNA from MaTu cells revealed presence of abundant truncated forms of L RNA. Z protein-specific rabbit antibodies were produced to glutathione S-transferase (GST)-Z fusion protein expressed in E. coli and used for the detection of Z protein in MaTu cells. Western blot and immunofluorescence analyses detected relatively high levels of Z protein indicating its role in maintenance of persistent LCMV. (authors)

  18. FRACTAL VISCOUS FINGERING AND ITS SCALING STRUCTURE INRANDOM SIERPINSKI CARPET

    田巨平; 姚凯伦

    2001-01-01

    Viscous fingering (VF) in the random Sierpinski carpet is investigated by means of the successive over-relaxation technique and under the assumption that bond radii are of Rayleigh distribution. In the random Sierpinski network,the VF pattern of porous media in the limit M → ∞ (M is the viscosity ratio and equals η2/η1 where η1 and η2 are the viscosities of the injected and displaced fluids, respectively) is found to be similar to the diffusion-limited aggregation (DLA) pattern. The interior of the cluster of the displacing fluid is compact on long length scales when M=1, and the pores in the interior of the cluster have been completely swept by the displacing fluid. For finite values of M, such as M >10, the pores in the interior of the cluster have been only partly swept by the displacing fluid on short length scales.But for values of M in I < M <5, the pores in the interior of the cluster have been completely swept by the displacing fluid on short length scales. The symmetry of the growth of VF is broken by randomizing the positions of the holes.The fractal dimension for VF in fractal space is calculated. However, the sweep efficiency of the displacement processes mainly depends upon the length of the network system and also on the viscosity ratio M. The fractal dimension D can be reasonably regarded as a useful parameter to evaluate the sweep efficiencies. The topology and geometry of the porous media have a strong effect on the structure of VF and the displacement process. The distribution of velocities normal to the interface has been studied by means of multifractal theory. Results show that the distribution is consistent with the hypothesis that, for a system of size L, Lf(α) sites have velocities scaling as L-α; and the scaling function f(α) is measured and its variation with M is found.

  19. Alterations in dendrite and spine morphology of cortical pyramidal neurons in DISC1-binding zinc finger protein (DBZ Knockout mice

    Tsuyoshi Hattori

    2015-04-01

    Full Text Available Dendrite and dendritic spine formation are crucial for proper brain function. DISC1-binding zinc finger protein (DBZ was first identified as a Disrupted-In-Schizophrenia1 (DISC1 binding partner. DBZ is highly expressed in the cerebral cortex of developing and adult rodents and is involved in neurite formation, cell positioning, and the development of interneurons and oligodendrocytes. The functional roles of DBZ in postnatal brain remain unknown; thus we investigated cortical pyramidal neuron morphology in DBZ knockout (KO mice. Morphological analyses by Golgi staining alone in DBZ KO mice revealed decreased dendritic arborization, increased spine density. A morphological analysis of the spines revealed markedly increased numbers of thin spines. To investigate whole spine structure in detail, electron tomographic analysis using ultra-high voltage electron microscopy combined with Golgi staining was performed. Tomograms and three-dimensional models of spines revealed that the spines of DBZ KO mice exhibited two types of characteristic morphology, filopodia-like spines and abnormal thin-necked spines having an extremely thin spine neck. Moreover, conventional electron microscopy revealed significantly decreased number of postsynaptic densities (PSDs in spines of DBZ KO mice. In conclusion, DBZ deficiency impairs the morphogenesis of dendrites and spines in cortical pyramidal neurons.

  20. Alterations in dendrite and spine morphology of cortical pyramidal neurons in DISC1-binding zinc finger protein (DBZ) knockout mice.

    Koyama, Yoshihisa; Hattori, Tsuyoshi; Nishida, Tomoki; Hori, Osamu; Tohyama, Masaya

    2015-01-01

    Dendrite and dendritic spine formation are crucial for proper brain function. DISC1-binding zinc finger protein (DBZ) was first identified as a Disrupted-In-Schizophrenia1 (DISC1) binding partner. DBZ is highly expressed in the cerebral cortex of developing and adult rodents and is involved in neurite formation, cell positioning, and the development of interneurons and oligodendrocytes. The functional roles of DBZ in postnatal brain remain unknown; thus we investigated cortical pyramidal neuron morphology in DBZ knockout (KO) mice. Morphological analyses by Golgi staining alone in DBZ KO mice revealed decreased dendritic arborization, increased spine density. A morphological analysis of the spines revealed markedly increased numbers of thin spines. To investigate whole spine structure in detail, electron tomographic analysis using ultra-high voltage electron microscopy (UHVEM) combined with Golgi staining was performed. Tomograms and three-dimensional models of spines revealed that the spines of DBZ KO mice exhibited two types of characteristic morphology, filopodia-like spines and abnormal thin-necked spines having an extremely thin spine neck. Moreover, conventional electron microscopy revealed significantly decreased number of postsynaptic densities (PSDs) in spines of DBZ KO mice. In conclusion, DBZ deficiency impairs the morphogenesis of dendrites and spines in cortical pyramidal neurons. PMID:25983680

  1. Conservation, diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome

    Böhm Siegfried

    2004-07-01

    Full Text Available Background The classical C2H2 zinc finger domain is involved in a wide range of functions and can bind to DNA, RNA and proteins. The comparison of zinc finger proteins in several eukaryotes has shown that there is a lot of lineage specific diversification and expansion. Although the number of characterized plant proteins that carry the classical C2H2 zinc finger motifs is growing, a systematic classification and analysis of a plant genome zinc finger gene set is lacking. Results We found through in silico analysis 176 zinc finger proteins in Arabidopsis thaliana that hence constitute the most abundant family of putative transcriptional regulators in this plant. Only a minority of 33 A. thaliana zinc finger proteins are conserved in other eukaryotes. In contrast, the majority of these proteins (81% are plant specific. They are derived from extensive duplication events and form expanded families. We assigned the proteins to different subgroups and families and focused specifically on the two largest and evolutionarily youngest families (A1 and C1 that are suggested to be primarily involved in transcriptional regulation. The newly defined family A1 (24 members comprises proteins with tandemly arranged zinc finger domains. Family C1 (64 members, earlier described as the EPF-family in Petunia, comprises proteins with one isolated or two to five dispersed fingers and a mostly invariant QALGGH motif in the zinc finger helices. Based on the amino acid pattern in these helices we could describe five different signature sequences prevalent in C1 zinc finger domains. We also found a number of non-finger domains that are conserved in these families. Conclusions Our analysis of the few evolutionarily conserved zinc finger proteins of A. thaliana suggests that most of them could be involved in ancient biological processes like RNA metabolism and chromatin-remodeling. In contrast, the majority of the unique A. thaliana zinc finger proteins are known or

  2. Stable expression of mtlD gene imparts multiple stress tolerance in finger millet.

    Ramanna Hema

    Full Text Available Finger millet is susceptible to abiotic stresses, especially drought and salinity stress, in the field during seed germination and early stages of seedling development. Therefore developing stress tolerant finger millet plants combating drought, salinity and associated oxidative stress in these two growth stages is important. Cellular protection through osmotic adjustment and efficient free radical scavenging ability during abiotic stress are important components of stress tolerance mechanisms in plants. Mannitol, an osmolyte, is known to scavenge hydroxyl radicals generated during various abiotic stresses and thereby minimize stress damage in several plant species. In this study transgenic finger millet plants expressing the mannitol biosynthetic pathway gene from bacteria, mannitol-1-phosphate dehydrogenase (mtlD, were developed through Agrobacterium tumefaciens-mediated genetic transformation. mtlD gene integration in the putative transgenic plants was confirmed by Southern blot. Further, performance of transgenic finger millet under drought, salinity and oxidative stress was studied at plant level in T1 generation and in T1 and T2 generation seedlings. Results from these experiments showed that transgenic finger millet had better growth under drought and salinity stress compared to wild-type. At plant level, transgenic plants showed better osmotic adjustment and chlorophyll retention under drought stress compared to the wild-type. However, the overall increase in stress tolerance of transgenics for the three stresses, especially for oxidative stress, was only marginal compared to other mtlD gene expressing plant species reported in the literature. Moreover, the Agrobacterium-mediated genetic transformation protocol developed for finger millet in this study can be used to introduce diverse traits of agronomic importance in finger millet.

  3. Potential application of FoldX force field based protein modeling in zinc finger nucleases design.

    He, ZuYong; Mei, Gui; Zhao, ChunPeng; Chen, YaoSheng

    2011-05-01

    Engineered sequence-specific zinc finger nucleases (ZFNs) make the highly efficient modification of eukaryotic genomes possible. However, most current strategies for developing zinc finger nucleases with customized sequence specificities require the construction of numerous tandem arrays of zinc finger proteins (ZFPs), and subsequent largescale in vitro validation of their DNA binding affinities and specificities via bacterial selection. The labor and expertise required in this complex process limits the broad adoption of ZFN technology. An effective computational assisted design strategy will lower the complexity of the production of a pair of functional ZFNs. Here we used the FoldX force field to build 3D models of 420 ZFP-DNA complexes based on zinc finger arrays developed by the Zinc Finger Consortium using OPEN (oligomerized pool engineering). Using nonlinear and linear regression analysis, we found that the calculated protein-DNA binding energy in a modeled ZFP-DNA complex strongly correlates to the failure rate of the zinc finger array to show significant ZFN activity in human cells. In our models, less than 5% of the three-finger arrays with calculated protein-DNA binding energies lower than -13.132 kcal mol(-1) fail to form active ZFNs in human cells. By contrast, for arrays with calculated protein-DNA binding energies higher than -5 kcal mol(-1), as many as 40% lacked ZFN activity in human cells. Therefore, we suggest that the FoldX force field can be useful in reducing the failure rate and increasing efficiency in the design of ZFNs. PMID:21455692

  4. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

    Wang, Gang G.; Song, Jikui; Wang, Zhanxin; Dormann, Holger L.; Casadio, Fabio; Li, Haitao; Luo, Jun-Li; Patel, Dinshaw J.; Allis, C. David; (MSKCC); (Scripps); (Rockefeller)

    2009-07-21

    Histone H3 lysine4 methylation (H3K4me) has been proposed as a critical component in regulating gene expression, epigenetic states, and cellular identities. The biological meaning of H3K4me is interpreted by conserved modules including plant homeodomain (PHD) fingers that recognize varied H3K4me states. The dysregulation of PHD fingers has been implicated in several human diseases, including cancers and immune or neurological disorders. Here we report that fusing an H3K4-trimethylation (H3K4me3)-binding PHD finger, such as the carboxy-terminal PHD finger of PHF23 or JARID1A (also known as KDM5A or RBBP2), to a common fusion partner nucleoporin-98 (NUP98) as identified in human leukaemias, generated potent oncoproteins that arrested haematopoietic differentiation and induced acute myeloid leukaemia in murine models. In these processes, a PHD finger that specifically recognizes H3K4me3/2 marks was essential for leukaemogenesis. Mutations in PHD fingers that abrogated H3K4me3 binding also abolished leukaemic transformation. NUP98-PHD fusion prevented the differentiation-associated removal of H3K4me3 at many loci encoding lineage-specific transcription factors (Hox(s), Gata3, Meis1, Eya1 and Pbx1), and enforced their active gene transcription in murine haematopoietic stem/progenitor cells. Mechanistically, NUP98-PHD fusions act as 'chromatin boundary factors', dominating over polycomb-mediated gene silencing to 'lock' developmentally critical loci into an active chromatin state (H3K4me3 with induced histone acetylation), a state that defined leukaemia stem cells. Collectively, our studies represent, to our knowledge, the first report that deregulation of the PHD finger, an 'effector' of specific histone modification, perturbs the epigenetic dynamics on developmentally critical loci, catastrophizes cellular fate decision-making, and even causes oncogenesis during mammalian development.

  5. Closure of digital arteries in high vascular tone states as demonstrated by measurement of systolic blood pressure in the fingers

    Krähenbühl, B; Nielsen, S L; Lassen, N A

    1977-01-01

    Finger systolic blood pressure (FSP) was measured indirectly in normal subjects and patients with primary Raynaud phenomenon by applying a thin-walled plastic cuff around the finger and a strain gauge more distally to detect volume changes. Inducing a high vascular tone in one or more fingers by...... direct cooling or intra-arterial noradrenaline infusion caused a marked drop in FSP in the exposed fingers, but not in the non-exposed fingers of the same hand. The fact that the non-exposed fingers retained the normal (arm systolic) pressure level is taken to indicate that palmar arch blood pressure...... also remained normal. In the high vascular tone state, a large transmural pressure difference must apparently be established before the digital arteries are forced open. The lowered opening pressure constitutes a manifestation of the closure phenomenon of the digital arteries described in patients with...

  6. An Optimal Design of Driving Mechanism in a 1 Degree of Freedom (d.o.f. Anthropomorphic Finger

    M. Ceccarelli

    2005-01-01

    Full Text Available Mechanisms can be used in finger design to obtain suitable actuation systems and to give stiff robust behavior in grasping tasks. The design of driving mechanisms for fingers has been attached at LARM in Cassino with the aim to obtain one degree of freedom actuation for an anthropomorphic finger. The dimensional design of a finger-driving mechanism has been formulated as a multi-objective optimization problem by using evaluation criteria for fundamental characteristics regarding with finger motion, grasping equilibrium and force transmission. The feasibility of the herein proposed optimum design procedure for a finger-driving mechanism has been tested by numerical examples that have been also used to enhance a prototype previously built at LARM in Cassino.

  7. Zinc-finger antiviral protein inhibits XMRV infection.

    Xinlu Wang

    Full Text Available BACKGROUND: The zinc-finger antiviral protein (ZAP is a host factor that specifically inhibits the replication of certain viruses, including Moloney murine leukemia virus (MoMLV, HIV-1, and certain alphaviruses and filoviruses. ZAP binds to specific viral mRNAs and recruits cellular mRNA degradation machinery to degrade the target RNA. The common features of ZAP-responsive RNA sequences remain elusive and thus whether a virus is susceptible to ZAP can only be determined experimentally. Xenotropic murine leukemia virus-related virus (XMRV is a recently identified γ-retrovirus that was originally thought to be involved in prostate cancer and chronic fatigue syndrome but recently proved to be a laboratory artefact. Nonetheless, XMRV as a new retrovirus has been extensively studied. Since XMRV and MoMLV share only 67.9% sequence identity in the 3'UTRs, which is the target sequence of ZAP in MoMLV, whether XMRV is susceptible to ZAP remains to be determined. FINDINGS: We constructed an XMRV-luc vector, in which the coding sequences of Gag-Pol and part of Env were replaced with luciferase-coding sequence. Overexpression of ZAP potently inhibited the expression of XMRV-luc in a ZAP expression-level-dependent manner, while downregulation of endogenous ZAP rendered cells more sensitive to infection. Furthermore, ZAP inhibited the spreading of replication-competent XMRV. Consistent with the previously reported mechanisms by which ZAP inhibits viral infection, ZAP significantly inhibited the accumulation of XMRV-luc mRNA in the cytoplasm. The ZAP-responsive element in XMRV mRNA was mapped to the 3'UTR. CONCLUSIONS: ZAP inhibits XMRV replication by preventing the accumulation of viral mRNA in the cytoplasm. Documentation of ZAP inhibiting XMRV helps to broaden the spectrum of ZAP's antiviral activity. Comparison of the target sequences of ZAP in XMRV and MoMLV helps to better understand the features of ZAP-responsive elements.

  8. ANALYSIS of Control Force Grasping for a Multifunctional Five Fingered Robot to Pick-up Various of Components

    Widhiada W.; Kumara N.S.; Nindhia T.G.T.

    2016-01-01

    Multi-fingered robot gripper has become popular in the major research topics as grasping an object in robotic systems. The author considers a matter of style-based control model for a multi-fingered robot hand grasping an object with a known geometric characteristics. This paper introduces design process and analysis of contact force the five fingered gripper suitable to handle several of objects. The author applied Simulink/SimMechanics, Support package Arduino and Inventor software packages...

  9. Tobacco-stained fingers: a clue for smoking-related disease or harmful alcohol use? A case–control study

    John, Gregor; Pasche, Sephora; Rothen, Nicole; Charmoy, Alexia; Delhumeau-Cartier, Cécile; Genné, Daniel

    2013-01-01

    Objective Tobacco stain on fingers is frequent. However, there is scarce description of this clinical sign. We aimed to explore tobacco stain on fingers as a marker of tobacco-related disease independent of cumulative tobacco exposure, and to find behavioural and environmental characteristics associated with those stains. Design Case–control study. Setting A Swiss community hospital of 180 beds. Participants 49 adults presenting tobacco-tars staining on fingers were matched to 49 control smok...

  10. Individual finger control of a modular prosthetic limb using high-density electrocorticography in a human subject

    Hotson, Guy; McMullen, David P.; Fifer, Matthew S.; Johannes, Matthew S.; Katyal, Kapil D.; Para, Matthew P.; Armiger, Robert; Anderson, William S.; Thakor, Nitish V.; Wester, Brock A.; Crone, Nathan E.

    2016-04-01

    Objective. We used native sensorimotor representations of fingers in a brain-machine interface (BMI) to achieve immediate online control of individual prosthetic fingers. Approach. Using high gamma responses recorded with a high-density electrocorticography (ECoG) array, we rapidly mapped the functional anatomy of cued finger movements. We used these cortical maps to select ECoG electrodes for a hierarchical linear discriminant analysis classification scheme to predict: (1) if any finger was moving, and, if so, (2) which digit was moving. To account for sensory feedback, we also mapped the spatiotemporal activation elicited by vibrotactile stimulation. Finally, we used this prediction framework to provide immediate online control over individual fingers of the Johns Hopkins University Applied Physics Laboratory modular prosthetic limb. Main results. The balanced classification accuracy for detection of movements during the online control session was 92% (chance: 50%). At the onset of movement, finger classification was 76% (chance: 20%), and 88% (chance: 25%) if the pinky and ring finger movements were coupled. Balanced accuracy of fully flexing the cued finger was 64%, and 77% had we combined pinky and ring commands. Offline decoding yielded a peak finger decoding accuracy of 96.5% (chance: 20%) when using an optimized selection of electrodes. Offline analysis demonstrated significant finger-specific activations throughout sensorimotor cortex. Activations either prior to movement onset or during sensory feedback led to discriminable finger control. Significance. Our results demonstrate the ability of ECoG-based BMIs to leverage the native functional anatomy of sensorimotor cortical populations to immediately control individual finger movements in real time.

  11. Prospective study of periostitis and finger clubbing in primary biliary cirrhosis and other forms of chronic liver disease.

    Epstein, O; Dick, R; Sherlock, S

    1981-01-01

    The association of finger clubbing and periostitis has been reported in primary biliary cirrhosis and, more rarely, in other forms of chronic liver disease. The prevalence of periostitis and its relationship to finger clubbing is unknown. In this prospective study, we have determined the prevalence of periostitis and finger clubbing in 74 patients with primary biliary cirrhosis and 54 with other forms of chronic liver disease. Clubbing was present in 24% of patients with primary biliary cirrh...

  12. A STUDY OF RELATIVE CORRELATION BETWEEN THE PATTERN OF FINGER PRINTS AND LIP PRINTS

    Murugan

    2014-10-01

    Full Text Available BACKGROUND AND OBJECTIVE: The use of conventional methods such as dactylography (study of finger prints & cheiloscopy (study of lip prints is of paramount importance, since personal identification by other means such as DNA analysis is sophisticated and not available in rural and developing countries. Fingerprint in its narrow sense is an impression left by the friction ridges of human fingers. The second prints of interest are lip prints. Studies of association between finger print and lip prints are scanty in literature. The present study was aimed to analyze the predominant pattern of lip and finger prints and to identify whether there is any correlation between these two parameters. MATERIALS AND METHODS: The study sample included 300 college students. Brown/pink colored lip stick was applied on the lips and the subject was asked to spread it uniformly over the lips by gentle movement of the lips. The unglazed white paper was then pressed uniformly over the lips. After the fingers were cleaned with tissue paper, the subjects were instructed to roll the tip of their fingers across the surface of an already made ink-stained pad, ensuring that the ink covered the entire pattern area. The inked finger was then enrolled over a white paper to obtain the print and analyzed using magnified hand lens. These prints were examined using magnifying glass, classified, and analyzed. The data was statistically analyzed by using Chi-square test. RESULTS: The percentage distribution of lip print shows that the most frequent lip print pattern in the male is Type I (36.8% and in female it is type II (34.4%. There is no statistically significant association between the pattern of finger prints and lip prints (p value = 0.9. CONCLUSION: It is known that individual parameters, i.e., lip print and finger print patterns play an important role in forensic identification. Correlation of these two parameters in our study did not show any significant association, hence

  13. A three-fingered, touch-sensitive, metrological micro-robotic assembly tool

    Torralba, Marta; Hastings, D. J.; Thousand, Jeffery D.; Nowakowski, Bartosz K.; Smith, Stuart T.

    2015-12-01

    This article describes a metrological, robotic hand to manipulate and measure micrometer size objects. The presented work demonstrates not only assembly operations, but also positioning control and metrology capability. Sample motion is achieved by a commercial positioning stage, which provides XYZ-displacements for assembly of components. A designed and manufactured gripper tool that incorporates 21 degrees-of-freedom for independent alignment of actuators, sensors, and the three fingers of this hand is presented. These fingers can be opened and closed by piezoelectric actuators through levered flexures providing an 80 μm displacement range measured with calibrated opto-interrupter based, knife-edge sensors. The operational ends of the fingers comprise of a quartz tuning fork with a 7 μm diameter 3.2 mm long carbon fiber extending from the end of one tuning fork tine. Finger-tip force-sensing is achieved by the monitoring of individual finger resonances typically at around 32 kHz. Experimental results included are focused on probe performance analysis. Pick and place operation using the three fingers is demonstrated with all fingers being continuously oscillated, a capability not possible with the previous single or two finger tweezer type designs. By monitoring electrical feedback during pick and place operations, changes in the response of the three probes demonstrate the ability to identify both grab and release operations. Component metrology has been assessed by contacting different micro-spheres of diameters 50(±7.5) μm, 135(±20) μm, and 140(±20) μm. These were measured by the micro robot to have diameters of 67, 133, and 126 μm respectively with corresponding deviations of 4.2, 4.9, and 4.3 μm. This deviation in the measured results was primarily due to the manual, joystick-based, contacting of the fingers, difficulties associated with centering the components to the axis of the hand, and lower contact sensitivity for the smallest sphere

  14. Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat

    Zschemisch Nils-Holger

    2012-11-01

    Full Text Available Abstract Background Engineered zinc-finger nucleases (ZFN represented an innovative method for the genome manipulation in vertebrates. ZFN introduced targeted DNA double strand breaks (DSB and initiated non-homologous end joining (NHEJ after pronuclear or cytoplasmatic microinjection into zygotes. Resulting frame shift mutations led to functional gene ablations in zebra fish, mice, pigs and also in laboratory rats. Therefore, we targeted the rat Rag1 gene essential for the V(DJ recombination within the immunoglobulin production process and for the differentiation of mature B and T lymphocytes to generate an immunodeficient rat model in the LEW/Ztm strain. Results After microinjection of Rag1 specific ZFN mRNAs in 623 zygotes of inbred LEW/Ztm rats 59 offspring were born from which one carried a 4 bp deletion. This frame shift mutation led to a premature stop codon and a subsequently truncated Rag1 protein confirmed by the loss of the full-length protein in Western Blot analysis. Truncation of the Rag1 protein was characterized by the complete depletion of mature B cells. The remaining T cell population contained mature CD4+/CD3+/TCRαβ+ as well as CD8+/CD3+/TCRαβ+ positive lymphocytes accompanied by a compensatory increase of natural killer cells in the peripheral blood. Reduction of T cell development in Rag1 mutant rats was associated with a hypoplastic thymus that lacked follicular structures. Histological evaluation also revealed the near-complete absence of lymphocytes in spleen and lymph nodes in the immunodeficient Rag1 mutant rat. Conclusion The Rag1 mutant rat will serve as an important model for transplantation studies. Furthermore, it may be used as a model for reconstitution experiments related to the immune system, particularly with respect to different populations of human lymphocytes, natural killer cells and autoimmune phenomena.

  15. Pre-contraction dynamic electrical impedance myography of the forearm finger flexors.

    Shiffman, C A

    2016-02-01

    Electrical activity in the sensory-motor and supplementary motor areas of the cerebral cortex is known to occur during a 'readiness interval', extending up to 2 s before the relevant muscle actually contracts. This paper presents evidence that there are also changes in the properties of the muscle itself during a similar preparatory period, as revealed by dynamic electrical impedance myography. 11 healthy subjects aged 23.5 ± 2.5 years were asked to perform a series of isometric gripping exercises during which the force, resistance and reactance of the forearm finger flexor muscles were monitored. A change in reactance, ΔX, or resistance, ΔR, which occurred before the generation of force, ΔF, was dubbed a 'PIC', shorthand for precontraction impedance change (subject to criteria to rule out the possibility of simple 'noise'), of which 1206 qualified in the entire subject cohort. Such PIC's are statistically well correlated when expressed in terms of differences between PIC and force onset times (r ≈ 0.9, p ≈ 0). This is demonstrated using a variation on the 'computer of average transients' method. Precontraction impedance changes (PICs) occurring as much as 2 s before the onset of force generation were found, in qualitative agreement with precontraction EEG activity reported in the literature. Also, a subset of PIC's was found in which the scaled and time-shifted ΔX(t) was virtually identical to ΔF(t). Since the occurrence and timing of all the PICs depend on oral commands, it is clear that the auditory cortex is likely involved, but the detailed mechanism coupling brain activity with PICs is not known. PMID:26814557

  16. Knockout of exogenous EGFP gene in porcine somatic cells using zinc-finger nucleases

    Watanabe, Masahito [Japan Science and Technology Agency (JST), ERATO, Nakauchi Stem Cell and Organ Regeneration Project, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639 (Japan); Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571 (Japan); Umeyama, Kazuhiro [Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571 (Japan); International Cluster for Bio-Resource Research, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571 (Japan); Matsunari, Hitomi [Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571 (Japan); Takayanagi, Shuko [Japan Science and Technology Agency (JST), ERATO, Nakauchi Stem Cell and Organ Regeneration Project, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639 (Japan); Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571 (Japan); Haruyama, Erika; Nakano, Kazuaki; Fujiwara, Tsukasa; Ikezawa, Yuka [Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571 (Japan); Nakauchi, Hiromitsu [Japan Science and Technology Agency (JST), ERATO, Nakauchi Stem Cell and Organ Regeneration Project, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639 (Japan); Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, Tokyo University, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639 (Japan); and others

    2010-11-05

    Research highlights: {yields} EGFP gene integrated in porcine somatic cells could be knocked out using the ZFN-KO system. {yields} ZFNs induced targeted mutations in porcine primary cultured cells. {yields} Complete absence of EGFP fluorescence was confirmed in ZFN-treated cells. -- Abstract: Zinc-finger nucleases (ZFNs) are expected as a powerful tool for generating gene knockouts in laboratory and domestic animals. Currently, it is unclear whether this technology can be utilized for knocking-out genes in pigs. Here, we investigated whether knockout (KO) events in which ZFNs recognize and cleave a target sequence occur in porcine primary cultured somatic cells that harbor the exogenous enhanced green fluorescent protein (EGFP) gene. ZFN-encoding mRNA designed to target the EGFP gene was introduced by electroporation into the cell. Using the Surveyor nuclease assay and flow cytometric analysis, we confirmed ZFN-induced cleavage of the target sequence and the disappearance of EGFP fluorescence expression in ZFN-treated cells. In addition, sequence analysis revealed that ZFN-induced mutations such as base substitution, deletion, or insertion were generated in the ZFN cleavage site of EGFP-expression negative cells that were cloned from ZFN-treated cells, thereby showing it was possible to disrupt (i.e., knock out) the function of the EGFP gene in porcine somatic cells. To our knowledge, this study provides the first evidence that the ZFN-KO system can be applied to pigs. These findings may open a new avenue to the creation of gene KO pigs using ZFN-treated cells and somatic cell nuclear transfer.

  17. Knockout of exogenous EGFP gene in porcine somatic cells using zinc-finger nucleases

    Research highlights: → EGFP gene integrated in porcine somatic cells could be knocked out using the ZFN-KO system. → ZFNs induced targeted mutations in porcine primary cultured cells. → Complete absence of EGFP fluorescence was confirmed in ZFN-treated cells. -- Abstract: Zinc-finger nucleases (ZFNs) are expected as a powerful tool for generating gene knockouts in laboratory and domestic animals. Currently, it is unclear whether this technology can be utilized for knocking-out genes in pigs. Here, we investigated whether knockout (KO) events in which ZFNs recognize and cleave a target sequence occur in porcine primary cultured somatic cells that harbor the exogenous enhanced green fluorescent protein (EGFP) gene. ZFN-encoding mRNA designed to target the EGFP gene was introduced by electroporation into the cell. Using the Surveyor nuclease assay and flow cytometric analysis, we confirmed ZFN-induced cleavage of the target sequence and the disappearance of EGFP fluorescence expression in ZFN-treated cells. In addition, sequence analysis revealed that ZFN-induced mutations such as base substitution, deletion, or insertion were generated in the ZFN cleavage site of EGFP-expression negative cells that were cloned from ZFN-treated cells, thereby showing it was possible to disrupt (i.e., knock out) the function of the EGFP gene in porcine somatic cells. To our knowledge, this study provides the first evidence that the ZFN-KO system can be applied to pigs. These findings may open a new avenue to the creation of gene KO pigs using ZFN-treated cells and somatic cell nuclear transfer.

  18. Radiation burden to hands from handling 99Mo-sup(99m)Tc generators measured by UVVVR finger dosemeters

    The doses to the fingers of seven technicians carrying out elutions of the 99Mo-sup(99m)Tc generators were monitored using LiF RTL dosemeters placed on the volar sides of the thumb, the index and middle fingers, and aluminophosphate glass RTL dosemeters fixed to the dorsal or the volar side of the ring finger. The finger doses corresponded to 0.4 to 1.9% of the annual permissible dose to hands. The maximum value measured in one technician was 14.3 mGy at a whole-body dose of 1.8 mGy as measured by a film dosemeter. (Ha)

  19. Correlation Between Sonographic and In Vivo Measurement of A1 Pulleys in Trigger Fingers.

    Spirig, Andres; Juon, Bettina; Banz, Yara; Rieben, Robert; Vögelin, Esther

    2016-07-01

    The thickness of 210 A1 pulleys of 21 male and female healthy volunteers in two different age groups (20-35 y and 50-70 y) were measured by ultrasound. In a second group, the thickness of 15 diseased A1 pulleys and 15 A1 pulleys of the corresponding other hand of 10 patients with the clinical diagnosis of trigger finger were measured by ultrasound. During open trigger finger release, a strip of A1 pulley was excised and immediately measured using an electronic caliper. The average pulley thickness of healthy volunteers was 0.43-0.47 mm, compared to 0.77-0.79 mm in patients with trigger finger. Based on the receiver operating characteristic (ROC) curve, a diagnostic cut-off value of the pulley thickness at 0.62 mm was defined in order to differ a trigger finger from a healthy finger (sensitivity and specificity of 85%). The correlation between sonographic and effective intra-operative measurements of pulley thickness was linear and very strong (Pearson coefficient 0.86-0.90). In order to distinguish between healthy and diseased A1 pulleys, 0.62 mm is a simple value to use, which can be applied regardless of age, sex, body mass index (BMI) and height in adults. PMID:27126241

  20. [Fractal characteristics of capillary finger flow for NAPLs infiltrated in porous media].

    Li, Hui-Ying; Du, Xiao-Ming; Yang, Bin; Wu, Bin; Xu, Zhu; Shi, Yi; Fang, Ji-Dun; Li, Fa-Sheng

    2013-10-01

    Non-aqueous phase liquids (NAPLs) like petroleum hydrocarbons and chlorinated solvents have resulted in contamination of soils and ground water, which aroused widespread concern. It's quite important to delineate pollution area for remediation according to different soil types with pollutants properties in consideration. In this paper, a two-dimension visual sand box apparatus was constructed, with four typical NAPLs selected for infiltration experiments conducted in initially dry porous media. The main driving force was identified and fingering patterns were compared. The fractal dimension was used to give quantitative description. The present work indicates that the main driving force was capillary forces and the mechanism was the capillary fingering. The fingers varied from skeletal patterns to fleshy patterns and the infiltration area increased when the capillary number and the bond number decreased for NAPLs with the same level of viscosity. The high viscous force resulted in larger finger width and infiltration area. The same change between fluids happened in finer media. Fractal dimensions were positively correlated with the finger width and infiltration area, which is helpful in the pollution area characterization. PMID:24364331

  1. Adhesion and fingering in the lifting Hele-Shaw cell: role of the substrate.

    Sinha, S; Dutta, T; Tarafdar, S

    2008-03-01

    The lifting Hele-Shaw cell (LHSC) is used to study adhesion as well as viscous fingering. In the present paper we report a series of observations of development of the interface for different viscous fluids, both Newtonian and non-Newtonian, in a LHSC operated at a constant lifting force. Glass and perspex are used as the plates in two different sets of experiments. The objectives are 1) to measure the time required to separate the plates as a function of the lifting force and 2) to note the force above which viscous fingering appears. We find that for the Newtonian fluids, the plate separation time follows a universal power law with the lifting force, irrespective of fluid and substrate. The non-Newtonian fluids too, with proper scaling obey the same power law. The appearance of fingering, however, depends on the properties of the fluid as well as the substrate. We suggest a modified form of the capillary number which controls the onset of fingering; this new quantity, termed the "fingering parameter" involves the dielectric constants of the substrate and fluid in addition to the viscosity and surface tension. PMID:18385932

  2. The RGD finger of Del-1 is a unique structural feature critical for integrin binding

    Schürpf, Thomas; Chen, Qiang; Liu, Jin-huan; Wang, Rui; Springer, Timothy A.; Wang, Jia-huai (Harvard-Med)

    2012-11-13

    Developmental endothelial cell locus-1 (Del-1) glycoprotein is secreted by endothelial cells and a subset of macrophages. Del-1 plays a regulatory role in vascular remodeling and functions in innate immunity through interaction with integrin {alpha}{sub V}{beta}{sub 3}. Del-1 contains 3 epidermal growth factor (EGF)-like repeats and 2 discoidin-like domains. An Arg-Gly-Asp (RGD) motif in the second EGF domain (EGF2) mediates adhesion by endothelial cells and phagocytes. We report the crystal structure of its 3 EGF domains. The RGD motif of EGF2 forms a type II' {beta} turn at the tip of a long protruding loop, dubbed the RGD finger. Whereas EGF2 and EGF3 constitute a rigid rod via an interdomain calcium ion binding site, the long linker between EGF1 and EGF2 lends considerable flexibility to EGF1. Two unique O-linked glycans and 1 N-linked glycan locate to the opposite side of EGF2 from the RGD motif. These structural features favor integrin binding of the RGD finger. Mutagenesis data confirm the importance of having the RGD motif at the tip of the RGD finger. A database search for EGF domain sequences shows that this RGD finger is likely an evolutionary insertion and unique to the EGF domain of Del-1 and its homologue milk fat globule-EGF 8. The RGD finger of Del-1 is a unique structural feature critical for integrin binding.

  3. Robust Operation of Tendon-Driven Robot Fingers Using Force and Position-Based Control Laws

    Abdallah, Muhammad E (Inventor); Platt, Jr., Robert J. (Inventor); Reiland, Matthew J (Inventor); Hargrave, Brian (Inventor); Diftler, Myron A (Inventor); Strawser, Philip A (Inventor); Ihrke, Chris A. (Inventor)

    2013-01-01

    A robotic system includes a tendon-driven finger and a control system. The system controls the finger via a force-based control law when a tension sensor is available, and via a position-based control law when a sensor is not available. Multiple tendons may each have a corresponding sensor. The system selectively injects a compliance value into the position-based control law when only some sensors are available. A control system includes a host machine and a non-transitory computer-readable medium having a control process, which is executed by the host machine to control the finger via the force- or position-based control law. A method for controlling the finger includes determining the availability of a tension sensor(s), and selectively controlling the finger, using the control system, via the force or position-based control law. The position control law allows the control system to resist disturbances while nominally maintaining the initial state of internal tendon tensions.

  4. An endophytic fungus isolated from finger millet (Eleucine coracona produces anti-fungal natural products

    Walaa Kamel Mousa

    2015-10-01

    Full Text Available Finger millet is an ancient African cereal crop, domesticated 7000 years ago in Ethiopia, reaching India at 3000 BC. Finger millet is reported to be resistant to various fungal pathogens including Fusarium sp. We hypothesized that finger millet may host beneficial endophytes (plant-colonizing microbes that contribute to the antifungal activity. Here we report the first isolation of endophyte(s from finger millet. Five distinct fungal species were isolated from roots and predicted taxonomically based on 18S rDNA sequencing. Extracts from three putative endophytes inhibited growth of F. graminearum and three other pathogenic Fusarium species. The most potent anti-Fusarium strain (WF4, predicted to be a Phoma sp. was confirmed to behave as an endophyte using pathogenicity and confocal microscopy experiments. Bioassay-guided fractionation of the WF4 extract identified four anti-fungal compounds, viridicatol, tenuazonic acid, alternariol and alternariol monomethyl ether. All the purified compounds caused dramatic breakage of F. graminearum hyphae in vitro. These compounds have not previously been reported to have anti-Fusarium activity. None of the compounds, except for tenuazonic acid, have previously been reported to be produced by Phoma. We conclude that the ancient, disease-tolerant crop, finger millet, is a novel source of endophytic anti-fungal natural products. This paper suggests the value of the crops grown by subsistence farmers as sources of endophytes and their natural products. Application of these natural chemicals to solve real world problems will require further validation.

  5. Finger-powered electrophoretic transport of discrete droplets for portable digital microfluidics.

    Peng, Cheng; Wang, Yide; Sungtaek Ju, Y

    2016-07-01

    We report a finger-powered digital microfluidic device based on the electrophoretic transport of discrete droplets (EPD). An array of piezoelectric elements is connected in parallel to metal electrodes immersed in dielectric fluids. When deflected in a controlled sequence via human finger power, the piezoelectric elements charge and actuate droplets across each electrode pair through electrophoretic force. Successful droplet transportation requires the piezoelectric elements to provide both sufficient charge and voltage pulse duration. We quantify these requirements using numerical models to predict the electrical charges induced on the droplets and the corresponding electrophoretic forces. The models are experimentally validated by comparing the predicted and measured droplet translational velocities. We successfully demonstrated transport and merging of aqueous droplets over a range of droplet radii (0.6-0.9 mm). We further showed direct manipulation of body fluids, including droplets of saliva and urine, using our finger-powered EPD device. To facilitate practical implementation of multistep assays based on the approach, a hand/finger-rotated drum system with a programmable pattern of protrusions is designed to induce deflections of multiple piezoelectric elements and demonstrate programmable fluidic functions. An electrode-to-piezoelectric element connection scheme to minimize the number of piezoelectric elements necessary for a sequence of microfluidic functions is also explored. The present work establishes an engineering foundation to enable design and implementation of finger-powered portable EPD microfluidic devices. PMID:27292054

  6. Non-invasive determination of the irradiation dose in fingers using low-frequency EPR

    Zdravkova, M [Laboratory of Biomedical Magnetic Resonance, Universite catholique de Louvain, UCL, Avenue Hippocrate, 10, B-1200 Brussels (Belgium); Crokart, N [Laboratory of Biomedical Magnetic Resonance, Universite catholique de Louvain, UCL, Avenue Hippocrate, 10, B-1200 Brussels (Belgium); Trompier, F [Service de Dosimetrie Externe, Departement de Radioprotection et de Protection de l' Homme, Institut de Radioprotection et de Surete Nucleaire, IRSN, BP no 17, F-92262 Fontenay-aux-Roses Cedex (France); Beghein, N [Laboratory of Biomedical Magnetic Resonance, Universite catholique de Louvain, UCL, Avenue Hippocrate, 10, B-1200 Brussels (Belgium); Gallez, B [Laboratory of Biomedical Magnetic Resonance, Universite catholique de Louvain, UCL, Avenue Hippocrate, 10, B-1200 Brussels (Belgium); Debuyst, R [Laboratory of Biomedical Magnetic Resonance, Universite catholique de Louvain, UCL, Avenue Hippocrate, 10, B-1200 Brussels (Belgium)

    2004-07-07

    Several reports in the literature have described the effects of radiation in workers who exposed their fingers to intense radioactive sources. The radiation injuries occurring after local exposure to a high dose (20 to 100 Gy) could lead to the need for amputation. Follow-up of victims needs to be more rational with a precise knowledge of the irradiated area that risks tissue degradation and necrosis. It has been described previously that X-band electron paramagnetic resonance (EPR) spectroscopy could be used to assess the dose in irradiated amputated fingers. Here, we propose the use of low-frequency EPR spectroscopy to evaluate non-invasively the absorbed dose. Low-frequency microwaves are indeed less absorbed by water and penetrate more deeply into living material ({approx}10 mm in tissues using 1 GHz spectrometers). This work presents preliminary results obtained with baboon and human fingers compared with human dry phalanxes placed inside a surface-coil resonator. The EPR signal increased linearly with the dose. The ratio of the slopes of the dry bone to whole finger linear regression lines was around 5. The detection limit achievable with the present spectrometer and resonator is around 60 Gy, which is well within the range of accidentally exposed fingers. It is likely that the detection limit could be improved in the future, thanks to further technical spectrometer and resonator developments as well as to appropriate spectrum deconvolution into native and dosimetric signals.

  7. Active gesture-changeable underactuated finger for humanoid robot hand based on multiple tendons

    D. Che

    2010-12-01

    Full Text Available The concept called gesture-changeable under-actuated (GCUA function is utilized to improve the dexterities of traditional under-actuated hands and reduce the control difficulties of dexterous hands. Based on GCUA function, a novel mechanical finger by multiple tendons: GCUA-T finger, is designed. The finger uses tendon mechanisms to achieve GCUA function which includes traditional underactuated (UA grasping motion and special pre-bending (PB, or pre-shaping motion before UA grasping. Operation principles and force analyses of the fingers are given, and the effect of GCUA function on the movements of a hand is discussed. The finger can satisfy the requirements of grasping and operating with low dependence on control system and low cost on manufacturing expenses, which develops a new way between dexterous hand and traditional under-actuated hand.

    This paper was presented at the IFToMM/ASME International Workshop on Underactuated Grasping (UG2010, 19 August 2010, Montréal, Canada.

  8. Thermo-hydraulic and structural analysis for finger-based concept of ITER blanket first wall

    The blanket first wall is one of the main plasma facing components in ITER tokamak. The finger-typed first wall was proposed through the current design progress by ITER organization. In this concept, each first wall module is composed of a beam and twenty fingers. The main function of the first wall is to remove efficiently the high heat flux loading from the fusion plasma during its operation. Therefore, the thermal and structural performance should be investigated for the proposed finger-based design concept of first wall. The various case studies were performed for a unit finger model considering different loading conditions. The finite element model was made for a half of a module using symmetric boundary conditions to reduce the computational effort. The thermo-hydraulic analysis was performed to obtain the pressure drop and temperature profiles. Then the structural analysis was carried out using the maximum temperature distribution obtained in thermo-hydraulic analysis. Finally, the transient thermo-hydraulic analysis was performed for the generic first wall module to obtain the temperature evolution history considering cyclic heat flux loading with nuclear heating. After that, the thermo-mechanical analysis was performed at the time step when the maximum temperature gradient was occurred. Also, the stress analysis was performed for the component with a finger and a beam to check the residual stress of the component after thermal shrinkage assembly.

  9. Patient-specific prosthetic fingers by remote collaboration--a case study.

    John-John Cabibihan

    Full Text Available The concealment of amputation through prosthesis usage can shield an amputee from social stigma and help improve the emotional healing process especially at the early stages of hand or finger loss. However, the traditional techniques in prosthesis fabrication defy this as the patients need numerous visits to the clinics for measurements, fitting and follow-ups. This paper presents a method for constructing a prosthetic finger through online collaboration with the designer. The main input from the amputee comes from the Computer Tomography (CT data in the region of the affected and the non-affected fingers. These data are sent over the internet and the prosthesis is constructed using visualization, computer-aided design and manufacturing tools. The finished product is then shipped to the patient. A case study with a single patient having an amputated ring finger at the proximal interphalangeal joint shows that the proposed method has a potential to address the patient's psychosocial concerns and minimize the exposure of the finger loss to the public.

  10. An endophytic fungus isolated from finger millet (Eleusine coracana) produces anti-fungal natural products.

    Mousa, Walaa K; Schwan, Adrian; Davidson, Jeffrey; Strange, Philip; Liu, Huaizhi; Zhou, Ting; Auzanneau, France-Isabelle; Raizada, Manish N

    2015-01-01

    Finger millet is an ancient African cereal crop, domesticated 7000 years ago in Ethiopia, reaching India at 3000 BC. Finger millet is reported to be resistant to various fungal pathogens including Fusarium sp. We hypothesized that finger millet may host beneficial endophytes (plant-colonizing microbes) that contribute to the antifungal activity. Here we report the first isolation of endophyte(s) from finger millet. Five distinct fungal species were isolated from roots and predicted taxonomically based on 18S rDNA sequencing. Extracts from three putative endophytes inhibited growth of F. graminearum and three other pathogenic Fusarium species. The most potent anti-Fusarium strain (WF4, predicted to be a Phoma sp.) was confirmed to behave as an endophyte using pathogenicity and confocal microscopy experiments. Bioassay-guided fractionation of the WF4 extract identified four anti-fungal compounds, viridicatol, tenuazonic acid, alternariol, and alternariol monomethyl ether. All the purified compounds caused dramatic breakage of F. graminearum hyphae in vitro. These compounds have not previously been reported to have anti-Fusarium activity. None of the compounds, except for tenuazonic acid, have previously been reported to be produced by Phoma. We conclude that the ancient, disease-tolerant crop, finger millet, is a novel source of endophytic anti-fungal natural products. This paper suggests the value of the crops grown by subsistence farmers as sources of endophytes and their natural products. Application of these natural chemicals to solve real world problems will require further validation. PMID:26539183

  11. [Study of mechanical effects of the EVA glove on finger base with finite element modeling].

    Li, Zhuoyou; Ding, Li; Yue, Guodong

    2013-08-01

    The hand strength of astronauts, when they are outside the space capsule, is highly influenced by the residual pressure (the pressure difference between inside pressure and outside one of the suit) of extravehicular activity spacesuit glove and the pressure exerted by braided fabric. The hand strength decreases significantly on extravehicular activity, severely reducing the operation efficiency. To measure mechanical influence caused by spacesuit glove on muscle-tendon and joints, the present paper analyzes the movement anatomy and biomechanical characteristics of gripping, and then proposes a grip model. With phalangeal joint simplified as hinges, seven muscles as a finger grip energy unit, the Hill muscle model was used to compute the effects. We also used ANSYS in this study to establish a 3-D finite element model of an index finger which included both bones and muscles with glove, and then we verified the model. This model was applied to calculate the muscle stress in various situations of bare hands or hands wearing gloves in three different sizes. The results showed that in order to achieve normal grip strength with the influence caused by superfluous press, the finger's muscle stress should be increased to 5.4 times of that in normal situation, with most of the finger grip strength used to overcome the influence of superfluous pressure. When the gap between the finger surface and the glove is smaller, the mechanical influence which superfluous press made will decrease. The results would provide a theoretical basis for the design of the EVA Glove. PMID:24059053

  12. Saffman-Taylor fingering: why it is not a proper upscaled model of viscous fingering in a (even two-dimensional) random porous medium

    Meheust, Y.; Toussaint, R.; Lovoll, G.; Maloy, K. J.

    2015-12-01

    P.G. Saffman & G. Taylor (1958) studied the stability of the interface between two immiscible fluids of different densities and viscosities when one displaces the other inside a Hele-Shaw (HS) cell. They showed that with a horizontal cell and if the displaced fluid is the more viscous, the interface is unstable and leads to a viscous fingering which they nearly fully modeled [1]. The HS geometry was introduced as a geometry imposing the same flow behavior as the Darcy-scale flow in a two-dimensional (2D) porous medium, and therefore allowing an analogy between the two configurations. This is however not obvious, since capillary forces act at very different scales in the two. Later, researchers performing unstable displacement experiments in HS cells containing random 2D porous media also observed viscous fingering at large viscosity ratios, but with invasion patterns very different from those of Saffman and Taylor (ST) [2-3]. It was however considered that the two processes were both Laplacian growth processes, i.e., processes in which the invasion probability density is proportional to the pressure gradient. Ten years ago, we investigated viscously-unstable drainage in 2D porous media experimentally and measured the growth activity as well as occupation probability maps for the invasion process [4-5]. We concluded that in viscous fingering in 2D porous media, the activity was rather proportional to the square of the pressure gradient magnitude (a so-called DBM model of exponent 2), so that the universality class of the growth/invasion process was different from that of ST viscous fingering. We now strengthen our claim with new results based on the comparison of (i) pressure measurements with the pressure field around a finger such as described by the ST analytical model, and (ii) branching angles in the invasion patterns with those expected for DBMs of various exponents. [1] Saffman, P. G. and Taylor, G. Proc. Soc. London 1958(Ser A 245), 312-329. [2] Lenormand, R

  13. Development of a New RF Finger concept for vacuum beam line interconnections

    Garion, C; Rambeau, H

    2012-01-01

    RF contact fingers are primarily used as a transition element to absorb the thermal expansion of vacuum chambers during bake-out and also to compensate for mechanical tolerances. They have to carry the beam image current to avoid the generation of Higher Order Modes and to reduce beam impedances. They are usually made out of copper beryllium thin sheets and are therefore very fragile and critical components. In this paper, a robust design based on a deformable finger concept is proposed. It allows the compensation of large longitudinal movements and also defaults such as transverse offset, twist or bending. The concept of this new RF fingers is first explained, then the design of the component is presented. The mechanical study based on a highly non-linear Finite Element model is shown as well as preliminary tests, including fatigue assessment, carried out on prototypes.

  14. An expanded binding model for Cys2His2 zinc finger protein–DNA interfaces

    Cys2His2 zinc finger (C2H2-ZF) proteins comprise the largest class of eukaryotic transcription factors. The 'canonical model' for C2H2-ZF protein–DNA interaction consists of only four amino acid–nucleotide contacts per zinc finger domain, and this model has been the basis for several efforts for computationally predicting and experimentally designing protein–DNA interfaces. Here, we perform a systematic analysis of structural and experimental binding data and find that, in addition to the canonical contacts, several other amino acid and base pair combinations frequently play a role in C2H2-ZF protein–DNA binding. We suggest an expansion of the canonical C2H2-ZF model to include one to three additional contacts, and show that computational approaches including these additional contacts improve predictions of DNA targets of zinc finger proteins

  15. Prosthetic finger phalanges with lifelike skin compliance for low-force social touching interactions

    Cabibihan, John-John; Ge, Shuzhi Sam; 10.1186/1743-0003-8-16

    2011-01-01

    Prosthetic arms and hands that can be controlled by the user's electromyography (EMG) signals are emerging. Eventually, these advanced prosthetic devices will be expected to touch and be touched by other people. As realistic as they may look, the currently available prosthetic hands have physical properties that are still far from the characteristics of human skins because they are much stiffer. In this paper, different configurations of synthetic finger phalanges have been investigated for their skin compliance behaviour and have been compared with the phalanges of the human fingers and a phalanx from a commercially available prosthetic hand. Handshake tests were performed to identify which areas on the human hand experience high contact forces. After these areas were determined, experiments were done on selected areas using an indenting probe to obtain the force-displacement curves. Finite element simulations were used to compare the force-displacement results of the synthetic finger phalanx designs with th...

  16. Onset of fingering instability in a finite slice of adsorbed solute

    Hota, Tapan Kumar; Mishra, Manoranjan

    2015-01-01

    The effect of a linear adsorption isotherm on the onset of fingering instability in a miscible displacement in the application of liquid chromatography, pollutant contamination in aquifers etc. is investigated. Such fingering instability on the solute dynamics arise due to the miscible viscus fingering (VF) between the displacing fluid and sample solvent. We use a Fourier pseudo-spectral method to solve the initial value problem appeared in the linear stability analysis. The present linear stability analysis is of generic type and it captures the early time diffusion dominated region which was never expressible through the quasi-steady state analysis (QSSA). In addition, it measures the onset of instability more accurately than the QSSA methods. It is shown that the onset time depends non-monotonically on the retention parameter of the solute adsorption. This qualitative influence of the retention parameter on the onset of instability resemblances with the results obtained from direct numerical simulations of...

  17. Study on Orthogonal and Symmetric Five-fingered Pneumatic Robot Hand

    Dexu Geng

    2012-11-01

    Full Text Available To improve the operation and the flexibility of the robot hand, in this paper we presented a new type pneumatic flexible robot hand based on the pneumatic artificial muscles and active flexible bending joints which developed in the previous research. The robot hand is imposed of five three-joint fingers; the middle finger is on the datum axis with the other four fingers orthogonal and symmetrical. The structure of the robot hand forms the dual-thumb oriented grasp model. Furthermore, we solved the large deformation and nonlinear problems of flexible joint perfectly in the posture model of the flexible robot hand, and then the mathematical equations on the four types of typical grasp posture are given respectively. Finally, both the simulation and the experiments were carried out to verify the mathematical model. The results show that the robot hand has good flexibility and compliance that can complete the operation well.

  18. Trigger Finger Appearing as Gradually Increasing Digital Nerve Disorder after Surgical Treatment

    Hiroyuki Tsuchie

    2013-01-01

    Full Text Available Trigger finger is a common disease, and operative treatments are often applied for it. Digital nerve injury is one of the complications of this surgical treatment, and paresthesia and sensory disturbance occur early after the operation. This paper presents a case of trigger finger appearing gradually as increasing digital nerve disorder after surgical treatment. In the second surgery, scar tissue covered the palmar MP joint where the A1 pulley had existed before, and palmar digital neurovascular tissue of the ulnar side was found on the inside of the scar. The ulnar digital nerve showed swelling like a neuroma, and bilateral digital nerves existed nearer to the center of the flexor pollicis longus tendon than normal digital nerves. Even when we operate on trigger finger by open release, we should create an appropriate surgical space for observation and be careful of digital nerve injury.

  19. Saffman-Taylor fingering with lateral injection with applications to imbibition coarsening dynamics

    Lagree, Bertrand; Zaleski, Stephane; Bondino, Igor; Josserand, Christophe; Popinet, Stephane

    2013-11-01

    We report 2D simulations of Saffman-Taylor fingering motivated by the analysis of experiments on the imbibition of porous media in square slab geometries. We use a Volume-of-Fluid (VOF) method to model a two-phase Darcy flow with a sharp interface between the two fluids. The Gerris code which allows efficient parallel computations with quad-tree mesh refinement is used. It is tested for accuracy and precision using several levels of refinement and comparing to reference simulations in the literature. A fingering pattern is observed after lateral injection of a less viscous fluid into a region filled with a more viscous one. Large fractal-like clusters are observed allowing the measurements of several scaling exponents which are compared to the known Diffusion-Limited-Aggregation (DLA) and Saffman-Taylor scalings. An interesting effect is the transition from a transient cylindrical DLA pattern to a small number then a single Saffman Taylor finger.

  20. Can Co(II) or Cd(II) substitute for Zn(II) in zinc fingers?

    P Rabindra Reddy; M Radhika

    2001-02-01

    Zinc finger domains consist of sequences of amino acids containing cysteine and histidine residues tetrahedrally coordinated to a zinc ion. The role of zinc in a DNA binding finger was considered purely structural due to the absence of redox chemistry in zinc. However, whether other metals e.g. Co(II) or Cd(II) can substitute Zn(II) is not settled. For an answer the detailed interaction of Co(II) and Cd(II) with cysteine methylester and histidine methylester has been investigated as a model for the zinc core in zinc fingers. The study was extended to different temperatures to evaluate the thermodynamic parameters associated with these interactions. The results suggest that zinc has a unique role.

  1. Decoding Finger Flexion using amplitude modulation from band-specific ECoG

    Liang, Nanying

    2009-01-01

    EEG-BCIs have been well studied in the past decades and implemented into several famous applications, like P300 speller and wheelchair controller. However, these interfaces are indirect due to low spatial resolution of EEG. Recently, direct ECoG-BCIs attract intensive attention because ECoG provides a higher spatial resolution and signal quality. This makes possible localization of the source of neural signals with respect to certain brain functions. In this article, we present a realization of ECoG-BCIs for finger flexion prediction provided by BCI competition IV. Methods for finger flexion prediction including feature extraction and selection are provided in this article. Results show that the predicted finger movement is highly correlated with the true movement when we use band-specific amplitude modulation.

  2. Decoding finger movements from ECoG signals using switching linear models

    Flamary, Rémi

    2011-01-01

    One of the major challenges of ECoG-based Brain-Machine Interfaces is the movement prediction of a human subject. Several methods exist to predict an arm 2-D trajectory. The fourth BCI Competition gives a dataset in which the aim is to predict individual finger movements (5-D trajectory). The difficulty lies in the fact that there is no simple relation between ECoG signals and finger movement. We propose in this paper to decode finger flexions using switching models. This method permits to simplify the system as it is now described as an ensemble of linear models depending on an internal state. We show that an interesting accuracy prediction can be obtained by such a model.

  3. Implementation of Robot Finger Using Shape Memory Alloys and Electrical Motors

    Terauchi, Mina; Zenba, Kota; Shimada, Akira

    This paper introduces a mechanical structure and control technique of a second robot finger as a system integration. The finger has been developed as element of a robot hand which has 20 joints and 16 degrees of freedom in order to express fingerspelling. The first joint of the finger is driven by small DC servo motor and the second and third joints are driven by shape-memory alloy (SMA) wires. The hand system consists of four parts of “hand mechanism”, “drive device”, “control unit” and “man-machine interface”. In order to implement cooperative smooth motions, the control system is designed based on experimental results related to system identification, and the position trajectory refernce is designed considering time delay on the SMA. Finally, we report the simulation and experimental control results to evaluate the presented system.

  4. Zinc finger as distance determinant in the flexible linker of intron endonuclease I-TevI.

    Dean, Amy B; Stanger, Matt J; Dansereau, John T; Van Roey, Patrick; Derbyshire, Victoria; Belfort, Marlene

    2002-06-25

    I-TevI, the phage T4 td intron-encoded endonuclease, recognizes a lengthy DNA target and initiates intron mobility by introducing a double-strand break in the homing site. The enzyme uses both sequence and distance determinants to cleave the DNA 23-25 bp upstream of the intron insertion site. I-TevI consists of an N-terminal catalytic domain and a C-terminal DNA-binding domain separated by a long, flexible linker. The DNA-binding domain consists of three subdomains: a zinc finger, a minor-groove binding alpha-helix, and a helix-turn-helix. In this study, a mutational analysis was undertaken to assess the roles of these subdomains in substrate binding and cleavage. Surprisingly, the zinc finger is not required for DNA binding or catalysis. Rather, the zinc finger is a component of the linker and directs the catalytic domain to cleave the homing site at a fixed distance from the intron insertion site. When the cleavage site (CS) is shifted outside a given range, wild-type I-TevI defaults to the fixed distance, whereas zinc-finger mutants have lost the distance determinant and search out the displaced cleavage sequences. Although counterintuitive, a protein containing a 19-aa deletion of the zinc finger can extend further than can wild-type I-TevI to cleave a distant CS sequence, and a Cys-to-Ala mutant of the ligands for zinc, nominally a longer protein, can retract to cleave at a closer CS sequence. Models are presented for the novel function of the zinc finger, as a molecular constraint, whereby intramolecular protein-protein interactions position the catalytic domain by "catalytic clamp" and/or "linker-organizer" mechanisms. PMID:12077294

  5. Transfer of either index finger extensor tendon to the extensor pollicis longus tendon

    Meads, Bryce M; Bogoch, Earl R

    2004-01-01

    BACKGROUND: Extensor pollicis longus (EPL) tendon ruptures have been treated succesfully with the transfer of the extensor indicis proprius (EIP) tendon. Situations exist in which, due to intraoperative observations, another tendon transfer may be considered preferable to the standard EIP transfer method. OBJECTIVES: To determine whether transfer of the extensor digitorum communis II (EDC II) tendon from the index finger to the EPL tendon, leaving the EIP tendon to the index finger intact, would serve as an equally efficient transfer and not adversely affect the function of the hand. METHODS: Two patients who had the EDC II tendon transferred to the ruptured EPL tendon, and two patients who had the EIP tendon transferred, were retrospectively reviewed. In each transfer type, one patient had suffered an EPL tendon rupture after a Colles’ fracture, and the other had rheumatoid arthritis. The rupture occurred on the non-dominant side in one patient in each transfer type. Each patient was examined and subjected to range of motion and power testing at least one year following surgery. RESULTS: All four patients showed a minimal extension lag with the lift off test, but there was no noticeable difference in range of motion, pinch grip and hand grip strength between the transfer types. Both EDC II transfer patients demonstrated an 8° to 15° loss of thumb interphalangeal joint flexion compared with the unoperated side; EIP transfer patients demonstrated less than a 5° loss. Three patients demonstrated a minor extension lag in the index finger and middle finger. Extension power of the thumb and index finger in all patients varied with wrist flexion and extension and ranged from 50% to 150% of the unoperated side. CONCLUSIONS: These case reports suggest that either index finger tendon may be successfully transferred in EPL tendon ruptures. PMID:24115870

  6. Design and fabrication of a three-finger prosthetic hand using SMA muscle wires

    Simone, Filomena; York, Alexander; Seelecke, Stefan

    2015-03-01

    Bio-inspired hand-like gripper systems based on shape memory alloy (SMA) wire actuation have the potential to enable a number of useful applications in, e.g., the biomedical field or industrial assembly systems. The inherent high energy density makes SMA solutions a natural choice for systems with lightweight, low noise and high force requirements, such as hand prostheses or robotic systems in a human/machine environment. The focus of this research is the development, design and realization of a SMA-actuated prosthetic hand prototype with three fingers. The use of thin wires (100 μm diameter) allows for high cooling rates and therefore fast movement of each finger. Grouping several small wires mechanically in parallel allows for high force actuation. To save space and to allow for a direct transmission of the motion to each finger, the SMA wires are attached directly within each finger, across each phalanx. In this way, the contraction of the wires will allow the movement of the fingers without the use of any additional gears. Within each finger, two different bundles of wires are mounted: protagonist ones that create bending movement and the antagonist ones that enable stretching of each phalanx. The resistance change in the SMA wires is measured during actuation, which allows for monitoring of the wire stroke and potentially the gripping force without the use of additional sensors. The hand is built with modern 3D-printing technologies and its performance while grasping objects of different size and shape is experimentally investigated illustrating the usefulness of the actuator concept.

  7. Finger muscle attachments for an OpenSim upper-extremity model.

    Jong Hwa Lee

    Full Text Available We determined muscle attachment points for the index, middle, ring and little fingers in an OpenSim upper-extremity model. Attachment points were selected to match both experimentally measured locations and mechanical function (moment arms. Although experimental measurements of finger muscle attachments have been made, models differ from specimens in many respects such as bone segment ratio, joint kinematics and coordinate system. Likewise, moment arms are not available for all intrinsic finger muscles. Therefore, it was necessary to scale and translate muscle attachments from one experimental or model environment to another while preserving mechanical function. We used a two-step process. First, we estimated muscle function by calculating moment arms for all intrinsic and extrinsic muscles using the partial velocity method. Second, optimization using Simulated Annealing and Hooke-Jeeves algorithms found muscle-tendon paths that minimized root mean square (RMS differences between experimental and modeled moment arms. The partial velocity method resulted in variance accounted for (VAF between measured and calculated moment arms of 75.5% on average (range from 48.5% to 99.5% for intrinsic and extrinsic index finger muscles where measured data were available. RMS error between experimental and optimized values was within one standard deviation (S.D of measured moment arm (mean RMS error = 1.5 mm < measured S.D = 2.5 mm. Validation of both steps of the technique allowed for estimation of muscle attachment points for muscles whose moment arms have not been measured. Differences between modeled and experimentally measured muscle attachments, averaged over all finger joints, were less than 4.9 mm (within 7.1% of the average length of the muscle-tendon paths. The resulting non-proprietary musculoskeletal model of the human fingers could be useful for many applications, including better understanding of complex multi-touch and gestural movements.

  8. Finger muscle attachments for an OpenSim upper-extremity model.

    Lee, Jong Hwa; Asakawa, Deanna S; Dennerlein, Jack T; Jindrich, Devin L

    2015-01-01

    We determined muscle attachment points for the index, middle, ring and little fingers in an OpenSim upper-extremity model. Attachment points were selected to match both experimentally measured locations and mechanical function (moment arms). Although experimental measurements of finger muscle attachments have been made, models differ from specimens in many respects such as bone segment ratio, joint kinematics and coordinate system. Likewise, moment arms are not available for all intrinsic finger muscles. Therefore, it was necessary to scale and translate muscle attachments from one experimental or model environment to another while preserving mechanical function. We used a two-step process. First, we estimated muscle function by calculating moment arms for all intrinsic and extrinsic muscles using the partial velocity method. Second, optimization using Simulated Annealing and Hooke-Jeeves algorithms found muscle-tendon paths that minimized root mean square (RMS) differences between experimental and modeled moment arms. The partial velocity method resulted in variance accounted for (VAF) between measured and calculated moment arms of 75.5% on average (range from 48.5% to 99.5%) for intrinsic and extrinsic index finger muscles where measured data were available. RMS error between experimental and optimized values was within one standard deviation (S.D) of measured moment arm (mean RMS error = 1.5 mm < measured S.D = 2.5 mm). Validation of both steps of the technique allowed for estimation of muscle attachment points for muscles whose moment arms have not been measured. Differences between modeled and experimentally measured muscle attachments, averaged over all finger joints, were less than 4.9 mm (within 7.1% of the average length of the muscle-tendon paths). The resulting non-proprietary musculoskeletal model of the human fingers could be useful for many applications, including better understanding of complex multi-touch and gestural movements. PMID:25853869

  9. Proteomic analysis of MCF-7 cell lines expressing the zinc-finger or the proline-rich domain of retinoblastoma-interacting-zinc-finger protein.

    Chambery, Angela; Farina, Annarita; Di Maro, Antimo; Rossi, Mariangela; Abbondanza, Ciro; Moncharmont, Bruno; Malorni, Livia; Cacace, Giuseppina; Pocsfalvi, Gabriella; Malorni, Antonio; Parente, Augusto

    2006-05-01

    To identify a growth-promoting activity related to retinoblastoma-interacting-zinc-finger (RIZ) protein, differential protein expression of MCF-7 cell lines expressing the zinc-finger or the proline-rich domain of RIZ protein was analyzed by a robust bottom-up mass-spectrometry proteomic approach. Spots corresponding to qualitative and quantitative differences in protein expression have been selected and identified. Some of these proteins have been previously reported as being associated with different types of carcinomas or involved in cell proliferation and differentiation. Knowledge of specific differentially expressed proteins by MCF-7-derived cell lines expressing RIZ different domains will provide the basis for identifying a growth-promoting activity related to RIZ gene products. PMID:16674107

  10. Fingers Phrase Music Differently: Trial-to-Trial Variability in Piano Scale Playing and Auditory Perception Reveal Motor Chunking

    van Vugt, Floris Tijmen; Jabusch, Hans-Christian; Altenmüller, Eckart

    2012-01-01

    We investigated how musical phrasing and motor sequencing interact to yield timing patterns in the conservatory students’ playing piano scales. We propose a novel analysis method that compared the measured note onsets to an objectively regular scale fitted to the data. Subsequently, we segment the timing variability into (i) systematic deviations from objective evenness that are perhaps residuals of expressive timing or of perceptual biases and (ii) non-systematic deviations that can be inter...

  11. Fingers phrase music differently: trial-to-trial variability in piano scale playing and auditory perception reveal motor chunking

    Floris Tijmen Van Vugt; Hans-Christian eJabusch; Eckart eAltenmüller

    2012-01-01

    We investigated how musical phrasing and motor sequencing interact to yield timing patterns in the conservatory students' playing piano scales. We propose a novel analysis method that compared the measured note onsets to an objectively regular scale fitted to the data. Subsequently, we segment the timing variability into (i) systematic deviations from objective evenness that are perhaps residuals of expressive timing or of perceptual biases and (ii) non-systematic deviations that can be inter...

  12. Normal MR imaging findings of the midhand and fingers with anatomic correlation

    In the present article, we correlate MR imaging studies of cadavers, volunteers and patients with cadaveric dissection and sectioning. First anatomy at wrist level is discussed. In a next section, we address the midhand with the flexor and extensor tendons, and interosseous and lumbricalis muscles. The dorsal hood at the level of the metacarpophalangeal joint is also addressed. An overview of the anatomy of the thenar is provided. Finally, the flexor system of the fingers with pulleys and volar plates, as well as the central and distal insertion of the finger extensor tendons is discussed

  13. Prosthetic finger phalanges with lifelike skin compliance for low-force social touching interactions

    Ge Shuzhi

    2011-03-01

    Full Text Available Abstract Background Prosthetic arms and hands that can be controlled by the user's electromyography (EMG signals are emerging. Eventually, these advanced prosthetic devices will be expected to touch and be touched by other people. As realistic as they may look, the currently available prosthetic hands have physical properties that are still far from the characteristics of human skins because they are much stiffer. In this paper, different configurations of synthetic finger phalanges have been investigated for their skin compliance behaviour and have been compared with the phalanges of the human fingers and a phalanx from a commercially available prosthetic hand. Methods Handshake tests were performed to identify which areas on the human hand experience high contact forces. After these areas were determined, experiments were done on selected areas using an indenting probe to obtain the force-displacement curves. Finite element simulations were used to compare the force-displacement results of the synthetic finger phalanx designs with that of the experimental results from the human and prosthetic finger phalanges. The simulation models were used to investigate the effects of (a varying the internal topology of the finger phalanx and (b varying different materials for the internal and external layers. Results and Conclusions During handshake, the high magnitudes of contact forces were observed at the areas where the full grasping enclosure of the other person's hand can be achieved. From these areas, the middle phalanges of the (a little, (b ring, and (c middle fingers were selected. The indentation experiments on these areas showed that a 2 N force corresponds to skin tissue displacements of more than 2 mm. The results from the simulation model show that introducing an open pocket with 2 mm height on the internal structure of synthetic finger phalanges increased the skin compliance of the silicone material to 235% and the polyurethane material to

  14. Recurring fingered flow pathways in a water repellent sandy field soil

    Ritsema, C.J.; Dekker, L.W.; Van Den Elsen, E. G. M.; Oostindiel, K.; Steenhuis, T. S.; Nieber, J. L.

    1997-01-01

    International audience Field evidence of finger formation and reformation during Successive rain events over an eight months' observation period from June 1994 until January 1995 is presented. Fingered flow pathways were monitored in a no-tilled, grass-covered water repellent sandy field soil using an automated, stand-alone TDR device. Within a 2 m long and 0.7 m deep transect, 98 three-wire probes were installed horizontally at depths of 4, 12, 20, 30, 40, 55, and 70 cm. The horizontal di...

  15. Time of flight with a segmented plastic finger detector at high particle rate

    Improved primary beam intensities and implementation of fast ramping time converts directly into higher yields of exotic nuclei. Improvements to tracking detectors are necessary to allow for higher rates. The segmented plastic finger detector was refurbished, tested and used in several beam times at the FRS and a better resolution was obtained compared to conventional scintillator detectors especially at high particle rate (> 106 Hz). A new finger detector with higher segmentation is under development, it can allow for still higher rate and can be also used as tracking detector for the SuperFRS.

  16. Free Radial Forearm “Bunting” Flap for Reconstructing Soft-tissue Defects Involving Multiple Fingers

    Ataru Sunaga, MD

    2013-08-01

    Full Text Available Summary: Reconstruction of soft-tissue defects on multiple fingers is challenging because the number of recipient vessels for free flaps is limited. We report the use of a free radial forearm flap with multiple perforator-based skin islands for the reconstruction of complex soft-tissue defects involving multiple fingers. The injuries were caused by a heat press. The flap was transferred, like “bunting,” to the injured hand with an exteriorized pedicle. The technique presented here is advantageous because it simultaneously covers multiple defects and allows immediate hand therapy after the operation.

  17. Enhancing the Expressiveness of Fingers: Multi-touch Ring Menus for Everyday Applications

    Kammer, Dietrich; Lamack, Frank; Groh, Rainer

    In the future, environments equipped with interaction surfaces sensitive to touch input will be a key factor to enable ambient intelligence. The user's fingers become input devices, allowing simple and intuitive interaction, like the manipulation of digital objects. However, people are used to everyday applications offering a wide variety of menu choices. We evaluate ring menus to enhance the expressiveness of finger interaction on multi-touch devices. Applicability and limits of ring menus are discussed with regard to our implementation by means of a preliminary user study.

  18. Metal binding and folding properties of a minimalist Cys2His2 zinc finger peptide.

    Michael, S.F.; Kilfoil, V J; Schmidt, M.H.; Amann, B T; Berg, J M

    1992-01-01

    A minimalist Cys2His2 zinc finger peptide, Lys-Tyr-Ala-Cys-Ala-Ala-Cys-Ala-Ala-Ala-Phe-Ala-Ala-Lys-Ala-Ala-Leu-Ala- Ala-His-Ala-Ala-Ala-His-Ala-Lys, has been synthesized. Metal binding studies using Co2+ as a probe indicated that this peptide forms a 1:1 peptide/metal complex with a dissociation constant comparable to that observed for other zinc finger peptides. At high peptide concentrations, a 2:1 peptide/metal complex also forms, with four cysteinates coordinated to Co2+. Additional studi...

  19. Magnetic field effects on viscous fingering of a ferrofluid in a radial Hele-Shaw cell

    Herreman, Wietze [Laboratoire Louis Neel, CNRS, BP 166, 38042 Grenoble Cedex 9 (France); Molho, Pierre [Laboratoire Louis Neel, CNRS, BP 166, 38042 Grenoble Cedex 9 (France)]. E-mail: molho@grenoble.cnrs.fr; Neveu, Sophie [LI2C, Universite Pierre et Marie Curie, 4 Place Jussieu, 75252 Paris Cedex 05 (France)

    2005-03-15

    We have studied the effects of a magnetic field on viscous fingering when a ferrofluid is pushed in a more viscous liquid in a circular Hele-Shaw cell. The main effect of the magnetic field, as already known, is to stabilize interfaces parallel to the field and to destabilize interfaces normal to the field. Depending on the growth regime (quasi static, fingering, dendritic growth), which depends on parameters like the cell thickness and oil viscosity, the combination of field effect and anisotropy is analyzed through the various observed patterns.

  20. Ischemic Necrosis of Upper Lip, and All Fingers and Toes After Norepinephrine Use.

    Shin, Jin Yong; Roh, Si-Gyun; Lee, Nae-Ho; Yang, Kyung-Moo

    2016-03-01

    A 68-year-old woman with necrosis of total finger, toe, and upper lip was requested by department of internal medicine. She was diagnosed with septic shock and treated with norepinephrine 10 days ago. Norepinephrine is an often-used medicine for normalizing blood pressure in septic shock patients. Norepinephrine stimulates adrenergic receptors, causing vasoconstriction and the rise of blood pressure. These peripheral vasoconstrictions sometimes lead to ischemic changes in end organs. In this case report, the authors describe ischemic necrosis of the upper lip and all fingers and toes after norepinephrine use in a patient in the intensive care unit. PMID:26854781

  1. Radiotherapy preserves fingers in the management of subungual squamous cell carcinoma, obviating the need for amputation

    A retrospective study of the use of radiotherapy in 12 patients with subungual squamous cell carcinoma of the finger was conducted at two radiotherapy departments in the Netherlands. This malignancy has little tendency to metastasize and is usually treated by amputation. Primary radiotherapy resulted in a permanent local control of 92% with only one serious adverse effect leading to an amputation of the initially involved digit. No regional or distant failure was seen during follow-up. Radiotherapy should be considered as an alternative for amputation to treat patients with subungual squamous cell carcinoma of the finger

  2. Rabring7, a Novel Rab7 Target Protein with a RING Finger Motif

    Mizuno, Kouichi; Kitamura, Akiko; Sasaki, Takuya

    2003-01-01

    Rab7, a member of the Rab family small G proteins, has been shown to regulate intracellular vesicle traffic to late endosome/lysosome and lysosome biogenesis, but the exact roles of Rab7 are still undetermined. Accumulating evidence suggests that each Rab protein has multiple target proteins that function in the exocytic/endocytic pathway. We have isolated a new Rab7 target protein, Rabring7 (Rab7-interacting RING finger protein), using a CytoTrap system. It contains an H2 type RING finger mo...

  3. RF CMOS modeling: a scalable model of RF-MOSFET with different numbers of fingers

    Yu Yuning; Sun Lingling; Liu Jun, E-mail: yuyuning126@126.com [Key Laboratory of RF Circuits and Systems of Ministry of Education, Hangzhou Dianzi University, Hangzhou 310018 (China)

    2010-11-15

    A novel scalable model for multi-finger RF MOSFETs modeling is presented. All the parasitic components, including gate resistance, substrate resistance and wiring capacitance, are directly determined from the layout. This model is further verified using a standard 0.13 {mu}m RF CMOS process with nMOSFETs of different numbers of gate fingers, with the per gate width fixed at 2.5 {mu}m and the gate length at 0.13 {mu}m. Excellent agreement between measured and simulated S-parameters from 100 MHz to 20 GHz demonstrate the validity of this model.

  4. Expression and purification of a novel ZNF191 zinc finger protein——ZNF191 protein and its truncated zinc finger region ZNF191 (243—368)

    刘玉奇; 余龙; 余文浩; 施少林; 孙炳耘; 吴国俊; 黄仲贤

    1999-01-01

    ZNF191 is a new zine finger gene whieh has a 1107 bp open reading frame (ORF) and eneodes a 368 amino avid protein including a putative DNA-binding domain of four Cys2 His2 zine finger motifs at its C-terminal region. The ZNF191 cDNA is loeated in the chromosome 18q12.1 region where it is known that a variety of hereditary diseases are related to. Probably, this protein has potential function of stimulating the gene franscription. In order to examine the function and structure of ZNF191 protein, the ORF of ZNF191 and its zine finger region ZNF191(243--368) genes were inserted into PTSA-18 expression vector by PCR amplification, then the constructed genes were expressed in the PTSA-18/B121 (DE3) system. The two proteins were purified by DEAE-52, CM-23 and Heparin-Sepharose 4B columns. The pooled proteins showed a single band as assayed by Coomasie Brillian Blue Staining of an SDS/polyacryamide gel.

  5. C terminal retroviral-type zinc finger domain from the HIV-1 nucleocapsid protein is structurally similar to the N-terminal zinc finger domain

    Two-dimensional NMR spectroscopic and computational methods were employed for the structure determination of an 18-residue peptide with the amino acid sequence of the C-terminal retriviral-type (r.t.) zinc finger domain from the nucleocapsid protein (NCP) of HIV-1 [Zn(HIV1-F2)]. Unlike results obtained for the first retroviral-type zinc finger peptide, Zn (HIV1-F1) broad signals indicative of confomational lability were observed in the 1H NMR spectrum of An(HIV1-F2) at 25 C. The NMR signals narrowed upon cooling to -2 C, enabling complete 1H NMR signal assignment via standard two-dimensional (2D) NMR methods. Distance restraints obtained from qualitative analysis of 2D nuclear Overhauser effect (NOESY) data were sued to generate 30 distance geometry (DG) structures with penalties in the range 0.02-0.03 angstrom 2. All structures were qualitatively consistent with the experimental NOESY spectrum based on comparisons with 2D NOESY back-calculated spectra. These results indicate that the r.t. zinc finger sequences observed in retroviral NCPs, simple plant virus coat proteins, and in a human single-stranded nucleic acid binding protein share a common structural motif

  6. Herbivory responsive C2H2 zinc finger transcription factor protein StZFP2 from potato

    While C2H2 zinc finger transcription factors are often regulated by abiotic stress, their role during insect infestation has been overlooked. This study demonstrates that the transcripts of the zinc finger transcription factors StZFP1 and StZFP2 are induced in potato (Solanum tuberosum) upon infesta...

  7. Optimization and variability of motor behavior in multi-finger tasks: What variables does the brain use?

    Martin, Joel R.; Terekhov, Alexander V.; Latash, Mark L.; Zatsiorsky, Vladimir M.

    2014-01-01

    The neural control of movement has been described using different sets of elemental variables. Two possible sets of elemental variables have been suggested for finger pressing tasks: the forces of individual fingers and the finger commands (also called “finger modes” or “central commands”). In this study we analyze which of the two sets of the elemental variables is more likely used in the optimization of the finger force sharing and which set is used for the stabilization of performance. We used two recently developed techniques – the analytical inverse optimization (ANIO) and the uncontrolled manifold (UCM) analysis – to evaluate each set of elemental variables with respect to both aspects of performance. The results of the UCM analysis favored the finger commands as the elemental variables used for performance stabilization, while ANIO worked equally well on both sets of elemental variables. A simple scheme is suggested as to how the CNS could optimize a cost function dependent on the finger forces, but for the sake of facilitation of the feed-forward control it substitutes the original cost function by a cost function, which is convenient to optimize in the space of finger commands. PMID:23742067

  8. Differences in finger length ratio between males with autism, pervasive developmental disorder-not otherwise specified, ADHD, and anxiety disorders

    de Bruin, Esther I.; Verheij, Fop; Wiegman, T.; Ferdinand, Robert F.

    2006-01-01

    Children with autism have a relatively shorter index finger (2D) compared with their ring finger (4D). It is often presumed that the 2D:4D ratio is associated with fetal testosterone levels and that high fetal testosterone levels could play a role in the aetiology of autism. It is unknown whether th

  9. Multiple interferon stimulated genes synergize with the zinc finger antiviral protein to mediate anti-alphavirus activity.

    Sophiya Karki

    Full Text Available The zinc finger antiviral protein (ZAP is a host factor that mediates inhibition of viruses in the Filoviridae, Retroviridae and Togaviridae families. We previously demonstrated that ZAP blocks replication of Sindbis virus (SINV, the prototype Alphavirus in the Togaviridae family at an early step prior to translation of the incoming genome and that synergy between ZAP and one or more interferon stimulated genes (ISGs resulted in maximal inhibitory activity. The present study aimed to identify those ISGs that synergize with ZAP to mediate Alphavirus inhibition. Using a library of lentiviruses individually expressing more than 350 ISGs, we screened for inhibitory activity in interferon defective cells with or without ZAP overexpression. Confirmatory tests of the 23 ISGs demonstrating the largest infection reduction in combination with ZAP revealed that 16 were synergistic. Confirmatory tests of all potentially synergistic ISGs revealed 15 additional ISGs with a statistically significant synergistic effect in combination with ZAP. These 31 ISGs are candidates for further mechanistic studies. The number and diversity of the identified ZAP-synergistic ISGs lead us to speculate that ZAP may play an important role in priming the cell for optimal ISG function.

  10. Quantum chemical modelling of reactivity and selectivity of 1,2-dithiolanes towards retroviral and cellular zinc fingers

    Topol, Igor A.; Nemukhin, Alexander V.; Burt, Stanley K.

    Interactions of 1,2-dithiolane species with zinc-containing sites, which mimic the zinc finger domains of retroviral and the cellular zinc finger proteins, have been investigated by quantum chemistry tools. According to the calculations, the immediate domains of zinc binding sites in the cellular and retroviral zinc fingers interact differently with such agents of the disulphide family. Thus, when approaching the model cellular-type domains, the molecules of 1,2-dithiolanes experience considerable potential barriers along the reaction path. However, these species react practically barrier-less with the model retroviral-type domains at the correlated DFT level. The results of the quantum chemical modelling provide firm support to the selectivity of 1,2-dithiolanes towards retroviral and cellular zinc fingers. This can be of great practical importance for the design of therapeutics that accomplish functional inactivation of the zinc fingers of the human immunodeficiency virus (HIV-1) retroviral type nucleocapsid protein NCp7.

  11. On the continuum-scale simulation of gravity-driven fingers with hysteretic Richards equation: Trucation error induced numerical artifacts

    ELIASSI,MEHDI; GLASS JR.,ROBERT J.

    2000-03-08

    The authors consider the ability of the numerical solution of Richards equation to model gravity-driven fingers. Although gravity-driven fingers can be easily simulated using a partial downwind averaging method, they find the fingers are purely artificial, generated by the combined effects of truncation error induced oscillations and capillary hysteresis. Since Richards equation can only yield a monotonic solution for standard constitutive relations and constant flux boundary conditions, it is not the valid governing equation to model gravity-driven fingers, and therefore is also suspect for unsaturated flow in initially dry, highly nonlinear, and hysteretic media where these fingers occur. However, analysis of truncation error at the wetting front for the partial downwind method suggests the required mathematical behavior of a more comprehensive and physically based modeling approach for this region of parameter space.

  12. The ancient mammalian KRAB zinc finger gene cluster on human chromosome 8q24.3 illustrates principles of C2H2 zinc finger evolution associated with unique expression profiles in human tissues

    2010-01-01

    Background Expansion of multi-C2H2 domain zinc finger (ZNF) genes, including the Krüppel-associated box (KRAB) subfamily, paralleled the evolution of tetrapodes, particularly in mammalian lineages. Advances in their cataloging and characterization suggest that the functions of the KRAB-ZNF gene family contributed to mammalian speciation. Results Here, we characterized the human 8q24.3 ZNF cluster on the genomic, the phylogenetic, the structural and the transcriptome level. Six (ZNF7, ZNF34, ZNF250, ZNF251, ZNF252, ZNF517) of the seven locus members contain exons encoding KRAB domains, one (ZNF16) does not. They form a paralog group in which the encoded KRAB and ZNF protein domains generally share more similarities with each other than with other members of the human ZNF superfamily. The closest relatives with respect to their DNA-binding domain were ZNF7 and ZNF251. The analysis of orthologs in therian mammalian species revealed strong conservation and purifying selection of the KRAB-A and zinc finger domains. These findings underscore structural/functional constraints during evolution. Gene losses in the murine lineage (ZNF16, ZNF34, ZNF252, ZNF517) and potential protein truncations in primates (ZNF252) illustrate ongoing speciation processes. Tissue expression profiling by quantitative real-time PCR showed similar but distinct patterns for all tested ZNF genes with the most prominent expression in fetal brain. Based on accompanying expression signatures in twenty-six other human tissues ZNF34 and ZNF250 revealed the closest expression profiles. Together, the 8q24.3 ZNF genes can be assigned to a cerebellum, a testis or a prostate/thyroid subgroup. These results are consistent with potential functions of the ZNF genes in morphogenesis and differentiation. Promoter regions of the seven 8q24.3 ZNF genes display common characteristics like missing TATA-box, CpG island-association and transcription factor binding site (TFBS) modules. Common TFBS modules partly

  13. The ancient mammalian KRAB zinc finger gene cluster on human chromosome 8q24.3 illustrates principles of C2H2 zinc finger evolution associated with unique expression profiles in human tissues

    Ding Guohui

    2010-03-01

    Full Text Available Abstract Background Expansion of multi-C2H2 domain zinc finger (ZNF genes, including the Krüppel-associated box (KRAB subfamily, paralleled the evolution of tetrapodes, particularly in mammalian lineages. Advances in their cataloging and characterization suggest that the functions of the KRAB-ZNF gene family contributed to mammalian speciation. Results Here, we characterized the human 8q24.3 ZNF cluster on the genomic, the phylogenetic, the structural and the transcriptome level. Six (ZNF7, ZNF34, ZNF250, ZNF251, ZNF252, ZNF517 of the seven locus members contain exons encoding KRAB domains, one (ZNF16 does not. They form a paralog group in which the encoded KRAB and ZNF protein domains generally share more similarities with each other than with other members of the human ZNF superfamily. The closest relatives with respect to their DNA-binding domain were ZNF7 and ZNF251. The analysis of orthologs in therian mammalian species revealed strong conservation and purifying selection of the KRAB-A and zinc finger domains. These findings underscore structural/functional constraints during evolution. Gene losses in the murine lineage (ZNF16, ZNF34, ZNF252, ZNF517 and potential protein truncations in primates (ZNF252 illustrate ongoing speciation processes. Tissue expression profiling by quantitative real-time PCR showed similar but distinct patterns for all tested ZNF genes with the most prominent expression in fetal brain. Based on accompanying expression signatures in twenty-six other human tissues ZNF34 and ZNF250 revealed the closest expression profiles. Together, the 8q24.3 ZNF genes can be assigned to a cerebellum, a testis or a prostate/thyroid subgroup. These results are consistent with potential functions of the ZNF genes in morphogenesis and differentiation. Promoter regions of the seven 8q24.3 ZNF genes display common characteristics like missing TATA-box, CpG island-association and transcription factor binding site (TFBS modules. Common TFBS

  14. SSFSE sequence functional MRI of the human cervical spinal cord with complex finger tapping

    Purpose: Functional MR imaging of the human cervical spinal cord was carried out on volunteers during alternated rest and a complex finger tapping task, in order to detect image intensity changes arising from neuronal activity. Methods: Functional MR imaging data using single-shot fast spin-echo sequence (SSFSE) with echo time 42.4 ms on a 1.5 T GE Clinical System were acquired in eight subjects performing a complex finger tapping task. Cervical spinal cord activation was measured both in the sagittal and transverse imaging planes. Postprocessing was performed by AFNI (Analysis of Functional Neuroimages) software system. Results: Intensity changes (5.5-7.6%) were correlated with the time course of stimulation and were consistently detected in both sagittal and transverse imaging planes of the cervical spinal cord. The activated regions localized to the ipsilateral side of the spinal cord in agreement with the neural anatomy. Conclusion: Functional MR imaging signals can be reliably detected with finger tapping activity in the human cervical spinal cord using a SSFSE sequence with 42.4 ms echo time. The anatomic location of neural activity correlates with the muscles used in the finger tapping task.

  15. Finger photoplethysmogram pulse amplitude changes induced by flow-mediated dilation

    This study was conducted to investigate the utility and efficacy of finger photoplethysmogram pulse amplitude (PPG-AC) in comparison with the standard Doppler ultrasound in assessing an endothelial function via flow-mediated dilation (FMD). High-resolution B-mode scanning of the right brachial artery (BA) of 31 healthy subjects aged 39.7 ± 11.3 (range 22–64) years and 52 risk subjects aged 47.7 ± 10.8 (range 30–65) years were performed before and after 4 min of upper arm occlusion. Concurrent with the ultrasound measurement (where color Doppler imaging was used to enhance arterial boundary detection), PPG signals were recorded from both index fingers for cross evaluation and comparison. Our results show that the finger PPG-AC exhibits a similar response to that of the well-known BA dilation: following the release of pressure (cuff around the BA), the PPG-AC increases abruptly before slowly decreasing toward the baseline. The peak PPG-AC is reached significantly faster than the peak FMD measured by ultrasound among healthy and risk groups (P < 0.001). The proposed technique using a finger photoplethysmogram can be applied in a rapid and non-invasive assessment of peripheral vascular functions as an alternative low-cost and less operator-dependent tool compared to ultrasound

  16. Development of transgenic finger millet (Eleusine coracana (L.) Gaertn.) resistant to leaf blast disease

    S Ignacimuthu; S Antony Ceasar

    2012-03-01

    Finger millet plants conferring resistance to leaf blast disease have been developed by inserting a rice chitinase (chi11) gene through Agrobacterium-mediated transformation. Plasmid pHyg-Chi.11 harbouring the rice chitinase gene under the control of maize ubiquitin promoter was introduced into finger millet using Agrobacterium strain LBA4404 (pSB1). Transformed plants were selected and regenerated on hygromycin-supplemented medium. Transient expression of transgene was confirmed by GUS histochemical staining. The incorporation of rice chitinase gene in R0 and R1 progenies was confirmed by PCR and Southern blot analyses. Expression of chitinase gene in finger millet was confirmed by Western blot analysis with a barley chitinase antibody. A leaf blast assay was also performed by challenging the transgenic plants with spores of Pyricularia grisea. The frequency of transient expression was 16.3% to 19.3%. Stable frequency was 3.5% to 3.9%. Southern blot analysis confirmed the integration of 3.1 kb chitinase gene. Western blot analysis detected the presence of 35 kDa chitinase enzyme. Chitinase activity ranged from 19.4 to 24.8. In segregation analysis, the transgenic R1 lines produced three resistant and one sensitive for hygromycin, confirming the normal Mendelian pattern of transgene segregation. Transgenic plants showed high level of resistance to leaf blast disease compared to control plants. This is the first study reporting the introduction of rice chitinase gene into finger millet for leaf blast resistance.

  17. Finger beat-to-beat blood pressure responses to successive hand elevations.

    Raamat, R; Jagomägi, K; Talts, J; Mäger, I

    2009-06-01

    We investigated finger beat-to-beat blood pressure responses to a series of successive hand elevations in 14 normal volunteers. By passive elevation of the hand by 40 cm and lowering it again after a minute, calibrated hydrostatic pressure changes were induced in the finger arteries of the subjects. Three successive procedures with a 2-min interval between them were performed. Transitions between positions were completed smoothly over a 10-s period. Non-invasive beat-to-beat mean arterial pressure (MAP) in the finger arteries was measured by applying the servo-oscillometric physiograph (University of Tartu, Estonia). A good agreement between the evoked MAP changes during all the three hand elevations (-31.2, -30.4 and -30.0 mmHg, respectively) and the calculated hydrostatic pressure change (-31.0 mmHg) was obtained. The height difference of approximately 40 cm and rate of 4-5 cm/s can be recommended for the hand elevation test, greater postural changes and higher rates may diminish agreement between the measured blood pressure response and the corresponding hydrostatic pressure change. The applied hydrostatic test may be helpful for assessing the accuracy of beat-to-beat finger blood pressure measurement. PMID:19027338

  18. Effects of Mental and Physical Practice on a Finger Opposition Task among Children

    de Paula Asa, Sabrina Kyoko; Santos Melo, Mara Cristina; Piemonte, Maria Elisa Pimentel

    2014-01-01

    Purpose: We sought to compare the effects of physical practice (PP) and mental practice (MP) on the immediate and long-term learning of the finger-to-thumb opposition sequence task (FOS) in children; in addition, we investigated the transfer of this learning to an untrained sequence of movements and to the contralateral untrained hand. Method:…

  19. Modeling gravity-driven fingering in rough-walled fractures using modified percolation theory

    Pore scale invasion percolation theory is modified for imbibition of.wetting fluids into fractures. The effects of gravity, local aperture field geometry, and local in-plane air/water interfacial curvatureare included in the calculation of aperture filling potential which controls wetted structure growth within the fracture. The inclusion of gravity yields fingers oriented in the direction of the gravitational gradient. These fingers widen and tend to meander and branch more as the gravitational gradient decreases. In-plane interfacial curvature also greatly affects the wetted structure in both horizontal and nonhorizontal fractures causing the formation of macroscopic wetting fronts. The modified percolation model is used to simulate imbibition into an analogue rough-walled fracture where both fingering and horizontal imbibition experiments were previously conducted. Comparison of numerical and experimental results showed reasonably good agreement. This process oriented physical and numerical modeling is-a necessary step toward including gravity-driven fingering in models of flow and transport through unsaturated, fractured rock

  20. Multi-fingered haptic palpation utilizing granular jamming stiffness feedback actuators

    This paper describes a multi-fingered haptic palpation method using stiffness feedback actuators for simulating tissue palpation procedures in traditional and in robot-assisted minimally invasive surgery. Soft tissue stiffness is simulated by changing the stiffness property of the actuator during palpation. For the first time, granular jamming and pneumatic air actuation are combined to realize stiffness modulation. The stiffness feedback actuator is validated by stiffness measurements in indentation tests and through stiffness discrimination based on a user study. According to the indentation test results, the introduction of a pneumatic chamber to granular jamming can amplify the stiffness variation range and reduce hysteresis of the actuator. The advantage of multi-fingered palpation using the proposed actuators is proven by the comparison of the results of the stiffness discrimination performance using two-fingered (sensitivity: 82.2%, specificity: 88.9%, positive predicative value: 80.0%, accuracy: 85.4%, time: 4.84 s) and single-fingered (sensitivity: 76.4%, specificity: 85.7%, positive predicative value: 75.3%, accuracy: 81.8%, time: 7.48 s) stiffness feedback. (paper)

  1. On the incompatibility of Richards’ equation and finger-like infiltration in unsaturated homogeneous porous media

    Fürst, T.; Vodák, R.; Šír, Miloslav; Bíl, M.

    2009-01-01

    Roč. 45, č. 3 (2009), W03408. ISSN 0043-1397 R&D Projects: GA ČR GA526/08/1016 Institutional research plan: CEZ:AV0Z20600510 Keywords : Richards’ equation * finger-like infiltration * cellular automata Subject RIV: DA - Hydrology ; Limnology Impact factor: 2.447, year: 2009

  2. Optical coherence elastography for human finger-pad skin deformation studies

    Hu, Xuesong; Maiti, Raman; Boadi, Joseph; Li, Wei; Carré, Matt J.; Lewis, Roger; Franklin, Steven E.; Matcher, Stephen J.

    2016-03-01

    An optical coherence tomography (OCT) system with an A-scan rate of 20 kHz was developed for measuring the biomechanical properties of human finger-pad skin. Such an OCT system operates at a center wavelength of 890 nm with a spectral bandwidth of 150 nm resulting in a very good axial resolution of 2.6 μm. The measured sensitivity and sensitivity roll-off of the system were ~93 dB and ~6 dB mm-1, respectively. Elastographic B-scan images of the human finger-pad skin were constructed by using 1000 A-scans. Deformations of the human finger-pad before and after sliding, while pressed against a transparent optical glass plate under the action of 0.5-2 N force, were examined both at the surface and sub-surface. Biomechanical properties, i.e., deformation of the skin, finger-pad/glass interface contact area were studied.

  3. Low Level Laser Therapy (Lllt) for Chronic Joint Pain of the Elbow, Wrist and Fingers

    Okuni, Ikuko; Ushigome, Nobuyuki; Harada, Takashi; Ohshiro, Toshio; Musya, Yoshiro; Sekiguchi, Masayuki

    2012-01-01

    Background and Aims: In previous studies, we successfully applied Low Level Laser Therapy (LLLT) in patients with non-specific chronic pain of the shoulder joint and lower back. The purpose of the present study was to assess the effectiveness of LLLT for chronic joint pain of the elbow, wrist, and fingers.

  4. Testing of FTS fingers and interface using a passive compliant robot manipulator. [flight telerobot servicer

    Nguyen, Charles C.; Antrazi, Sami S.

    1992-01-01

    This report deals with testing of a pair of robot fingers designed for the Flight Telerobotic Servicer (FTS) to grasp a cylinder type of Orbital Replaceable Unit (ORU) interface. The report first describes the objectives of the study and then the testbed consisting of a Stewart Platform-based manipulator equipped with a passive compliant platform which also serves as a force/torque sensor. Kinematic analysis is then performed to provide a closed-form solution for the force inverse kinematics and iterative solution for the force forward kinematics using the Newton's Raphson Method. Mathematical expressions are then derived to compute force/torques applied to the FTS fingers during the mating/demating with the interface. The report then presents the three parts of the experimental study on the feasibility and characteristics of the fingers. The first part obtains data of forces applied by the fingers to the interface under various misalignments, the second part determines the maximum allowable capture angles for mating, and the third part processes and interprets the obtained force/torque data.

  5. DUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction.

    Muhammed Jamsheer K

    Full Text Available Zinc fingers are a ubiquitous class of protein domain with considerable variation in structure and function. Zf-FCS is a highly diverged group of C2-C2 zinc finger which is present in animals, prokaryotes and viruses, but not in plants. In this study we identified that a plant specific domain of unknown function, DUF581 is a zf-FCS type zinc finger. Based on HMM-HMM comparison and signature motif similarity we named this domain as FCS-Like Zinc finger (FLZ domain. A genome wide survey identified that FLZ domain containing genes are bryophytic in origin and this gene family is expanded in spermatophytes. Expression analysis of selected FLZ gene family members of A. thaliana identified an overlapping expression pattern suggesting a possible redundancy in their function. Unlike the zf-FCS domain, the FLZ domain found to be highly conserved in sequence and structure. Using a combination of bioinformatic and protein-protein interaction tools, we identified that FLZ domain is involved in protein-protein interaction.

  6. Evaluation of EEG Features in Decoding Individual Finger Movements from One Hand

    Ran Xiao

    2013-01-01

    Full Text Available With the advancements in modern signal processing techniques, the field of brain-computer interface (BCI is progressing fast towards noninvasiveness. One challenge still impeding these developments is the limited number of features, especially movement-related features, available to generate control signals for noninvasive BCIs. A few recent studies investigated several movement-related features, such as spectral features in electrocorticography (ECoG data obtained through a spectral principal component analysis (PCA and direct use of EEG temporal data, and demonstrated the decoding of individual fingers. The present paper evaluated multiple movement-related features under the same task, that is, discriminating individual fingers from one hand using noninvasive EEG. The present results demonstrate the existence of a broadband feature in EEG to discriminate individual fingers, which has only been identified previously in ECoG. It further shows that multiple spectral features obtained from the spectral PCA yield an average decoding accuracy of 45.2%, which is significantly higher than the guess level (P<0.05 and other features investigated (P<0.05, including EEG spectral power changes in alpha and beta bands and EEG temporal data. The decoding of individual fingers using noninvasive EEG is promising to improve number of features for control, which can facilitate the development of noninvasive BCI applications with rich complexity.

  7. Development of tip-splitting and side-branching patterns in elastic fingering

    Fontana, João V.; Gadêlha, Hermes; Miranda, José A.

    2016-03-01

    Elastic fingering supplements the already interesting features of the traditional viscous fingering phenomena in Hele-Shaw cells with the consideration that the two-fluid separating boundary behaves like an elastic membrane. Sophisticated numerical simulations have shown that under maximum viscosity contrast the resulting patterned shapes can exhibit either finger tip-splitting or side-branching events. In this work, we employ a perturbative mode-coupling scheme to get important insights into the onset of these pattern formation processes. This is done at lowest nonlinear order and by considering the interplay of just three specific Fourier modes: a fundamental mode n and its harmonics 2 n and 3 n . Our approach further allows the construction of a morphology diagram for the system in a wide range of the parameter space without requiring expensive numerical simulations. The emerging interfacial patterns are conveniently described in terms of only two dimensionless controlling quantities: the rigidity fraction C and a parameter Γ that measures the relative strength between elastic and viscous effects. Visualization of the rigidity field for the various pattern-forming structures supports the idea of an elastic weakening mechanism that facilitates finger growth in regions of reduced interfacial bending rigidity.

  8. Finger and toe temperature response to cold water and cold air exposure

    Struijs, N.R. van der; Es, E.M. van; Raymann, R.J.E.M.; Daanen, H.A.M.

    2008-01-01

    Introduction: Subjects with a weak cold-induced vasodilatation response (CIVD) to experimental cold-water immersion of the fingers in a laboratory setting have been shown to have a higher risk for local cold injuries when exposed to cold in real life. Most of the cold injuries in real life, however,

  9. A new TL finger ring dosimetry system with automated ring identification

    TL finger ring dosemeters, particularly if used during surgery, etc., have to be small, convenient to wear and suitable for cold sterilisation. This makes automated ring identification difficult to achieve. A new approach is described, based on a circular TLD chip mounted with Kapton foil on a small aluminium disc containing a miniaturised circular bar code (radial 6 digit ITF) and a six digit number. The ring is inserted into a disposable plastic finger ring and protected by a circular cover plate. This ring design is convenient to wear, fits all finger sizes and can be cold sterilised for multiple use in surgery. For readout the ring is opened by a semi-automated device and up to four bar coded discs inserted into a modified standard TLD card for automatic processing by Harshaw readers models 6600 or 8800. The reader contains a video bar code identification system based on a minaturised CCD camera and image processing by special PC software. The circular bar codes are mathematically linearised and decoded directly from the enhanced grey scale picture obtained with optimised illumination by power LEDs. The system described (Patent No. A 398005/1994) is a fast and economic solution for fully (or semi-) automated evaluation of TLD finger rings in larger personnel monitoring services. (author)

  10. 21 CFR 888.3200 - Finger joint metal/metal constrained uncemented prosthesis.

    2010-04-01

    ... prosthesis. 888.3200 Section 888.3200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... metal/metal constrained uncemented prosthesis. (a) Identification. A finger joint metal/metal constrained uncemented prosthesis is a device intended to be implanted to replace a metacarpophalangeal...

  11. 21 CFR 888.3220 - Finger joint metal/polymer constrained cemented prosthesis.

    2010-04-01

    ... prosthesis. 888.3220 Section 888.3220 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... metal/polymer constrained cemented prosthesis. (a) Identification. A finger joint metal/polymer constrained cemented prosthesis is a device intended to be implanted to replace a metacarpophalangeal...

  12. Control System Design of the YWZ Multi-fingered Dexterous Hand

    Wenzhen Yang

    2012-07-01

    Full Text Available The manipulation abilities of a multi‐fingered dexterous hand, such as motion in real‐time, flexibility, grasp stability etc., are largely dependent on its control system. This paper developed a control system for the YWZ dexterous hand, which had five fingers and twenty degrees of freedom (DOFs. All of the finger joints of the YWZ dexterous handwere active joints driven by twenty micro‐stepper motors respectively. The main contribution of this paper was that we were able to use stepper motor control to actuate the handʹs fingers, thus, increasing the hands feasibility. Based the actuators of the YWZ dexterous hand, we firstly developed an integrated circuit board (ICB, which was the communication hardware between the personal computer (PC and the YWZ dexterous hand. The ICB included a centre controller, twenty driver chips, a USB port and other electrical parts. Then, a communication procedure between the PC and the ICB was developed to send the control commands to actuate the YWZ dexterous hand. Experiment results showed that under this control system, the motion of the YWZ dexterous hand was real‐time; both the motion accuracy and the motion stability of the YWZ dexterous hand were reliable. Compared with other types of actuators related to dexterous hands, such as pneumatic servo cylinder, DC servo motor, shape memory alloy etc., experiment results verified that the stepper motors as actuatorsfor the dexterous handswere effective, economical, controllable and stable.

  13. Moisture-insensitive optical fingerprint scanner based on polarization resolved in-finger scattered light.

    Back, Seon-Woo; Lee, Yong-Geon; Lee, Sang-Shin; Son, Geun-Sik

    2016-08-22

    A moisture-insensitive optical fingerprint scanner (FPS) that is based on polarization resolved in-finger light is proposed and realized. Incident visible light, which is selectively fed to a fingerprint sample via a polarization beam splitter (PBS), is deemed to be partially scattered backward by tissues associated with the skin of the finger. The backscattered light is mostly index-guided in the ridge comprising the fingerprint, which has a higher refractive index, and is drastically dispersed in the valley, which is typically filled with water or air and so has a lower index. However, when light reflects directly off the surface of the finger skin, it fundamentally prevents the scanned image from being determined. The proposed FPS produces bright and dark intensity patterns that are alternately created on the surface of the PBS and correspond to the ridges and valleys, respectively. Thus, this method can especially distinguish between a fake synthetic fingerprint and a genuine fingerprint due to its use of in-finger scattered light. The scanner has been rigorously designed by carrying out ray-optic simulations depending on the wavelength, with tissue-induced scattering taken into account. The device was constructed by incorporating a wire-grid type PBS in conjunction with visible LED sources, including blue, green and red. The scanner adopting a blue LED, which exhibits the strongest light scattering, resulted in the best fingerprint image, enabling enhanced fidelity under the wet and dry situations. Finally, a fake synthetic fingerprint could be successfully discriminated. PMID:27557199

  14. A Finger-Shaped Tactile Sensor for Fabric Surfaces Evaluation by 2-Dimensional Active Sliding Touch

    Haihua Hu

    2014-03-01

    Full Text Available Sliding tactile perception is a basic function for human beings to determine the mechanical properties of object surfaces and recognize materials. Imitating this process, this paper proposes a novel finger-shaped tactile sensor based on a thin piezoelectric polyvinylidene fluoride (PVDF film for surface texture measurement. A parallelogram mechanism is designed to ensure that the sensor applies a constant contact force perpendicular to the object surface, and a 2-dimensional movable mechanical structure is utilized to generate the relative motion at a certain speed between the sensor and the object surface. By controlling the 2-dimensional motion of the finger-shaped sensor along the object surface, small height/depth variation of surface texture changes the output charge of PVDF film then surface texture can be measured. In this paper, the finger-shaped tactile sensor is used to evaluate and classify five different kinds of linen. Fast Fourier Transformation (FFT is utilized to get original attribute data of surface in the frequency domain, and principal component analysis (PCA is used to compress the attribute data and extract feature information. Finally, low dimensional features are classified by Support Vector Machine (SVM. The experimental results show that this finger-shaped tactile sensor is effective and high accurate for discriminating the five textures.

  15. Finger clubbing and aspartylglucosamine excretion in a laxative-abusing patient.

    Malmquist, J.; Ericsson, B; Hultén-Nosslin, M. B.; Jeppsson, J. O.; Ljungberg, O.

    1980-01-01

    A young woman with a previous history of anorexia nervosa presented with severe finger clubbing. Urine samples intermittently contained significant amounts of aspartylglucosamine. Liver biopsy showed abnormal cytoplasmic inclusions in phagocytic cells. The patient was found to be abusing senna laxative.

  16. The Role of Film in Teaching Political Science: 5 Fingers and Operation Cicero

    Bostock, William

    2011-01-01

    The idea that "film is an extraordinarily powerful teaching tool" (Champoux) is explored in relation to the film "5 Fingers" that presents an account of the true story of the reproduction and sale of top secret documents held by the British Ambassador in Ankara, Turkey to Nazi Germany by Elyesa Bazna, code named Cicero, arguably the most…

  17. Enhancing micronutrient content of beverage powder by incorporating malted finger millet

    Jaya Tripathi

    2014-12-01

    Full Text Available Introduction: There is growing interest in the role of the micronutrients in optimizing health, and in prevention or treatment of disease. Micronutrients play a central part in metabolism and in the maintenance of tissue function, an adequate intake therefore is necessary. Rationale: This research work was concerned with the development of micronutrient especially calcium rich instant health beverage powder from malted finger millet (Eleusine coracana and gurhal powder (Hibiscus rosa- sinensis. Aims & Objectives: In this study attempts have been made to investigate that whether the extruded malted finger millet flour and hibiscus flower powder has improved the nutritional and phytochemical quality of instant health beverage powder without deteriorating their sensory properties and whether it can be a supplement for calcium deficit sedentary women. Materials and methods: Instant health beverage powder was prepared by adding malted and extruded finger millet with glucose, hibiscus flower powder, citric acid and vanilla essence. All the ingredients were mixed well. Prior to consumption this powder was dissolved in water and stirred well manually. Further Instant health beverage powder was assessed for nutritional composition. Results: Results shows that beverage powder has very high content of protein (12.25 % and calcium (96.5 % along with highly beneficial neutraceutical properties as compared with the health drinks available in market, it is because of enhanced antioxidant activity resulted due to the incorporation of gurhal leaf powder and malting of the finger millet. Conclusion: This study may prove as a potential step to utilise malted finger millet as a supplement for calcium deficit women. The nutritional composition was found sufficient enough to meet approximately one fourth of RDA of Protein and Calcium as prescribed by NIN, India for sedentary women who are the main sufferers of calcium deficiencies in various life stages like

  18. Characterization of the contradictory chromatin signatures at the 3' exons of zinc finger genes.

    Kimberly R Blahnik

    Full Text Available The H3K9me3 histone modification is often found at promoter regions, where it functions to repress transcription. However, we have previously shown that 3' exons of zinc finger genes (ZNFs are marked by high levels of H3K9me3. We have now further investigated this unusual location for H3K9me3 in ZNF genes. Neither bioinformatic nor experimental approaches support the hypothesis that the 3' exons of ZNFs are promoters. We further characterized the histone modifications at the 3' ZNF exons and found that these regions also contain H3K36me3, a mark of transcriptional elongation. A genome-wide analysis of ChIP-seq data revealed that ZNFs constitute the majority of genes that have high levels of both H3K9me3 and H3K36me3. These results suggested the possibility that the ZNF genes may be imprinted, with one allele transcribed and one allele repressed. To test the hypothesis that the contradictory modifications are due to imprinting, we used a SNP analysis of RNA-seq data to demonstrate that both alleles of certain ZNF genes having H3K9me3 and H3K36me3 are transcribed. We next analyzed isolated ZNF 3' exons using stably integrated episomes. We found that although the H3K36me3 mark was lost when the 3' ZNF exon was removed from its natural genomic location, the isolated ZNF 3' exons retained the H3K9me3 mark. Thus, the H3K9me3 mark at ZNF 3' exons does not impede transcription and it is regulated independently of the H3K36me3 mark. Finally, we demonstrate a strong relationship between the number of tandemly repeated domains in the 3' exons and the H3K9me3 mark. We suggest that the H3K9me3 at ZNF 3' exons may function to protect the genome from inappropriate recombination rather than to regulate transcription.

  19. A Study on Self-Heating and Mutual Thermal Coupling in SiGe Multi-Finger HBTs

    Dwivedi, A. D. D.; D'Esposito, Rosario; Sahoo, Amit Kumar; Fregonese, Sebastien; Zimmer, Thomas

    2016-07-01

    In this paper, the self-heating and mutual thermal coupling in a state-of-the-art SiGe:C multi-finger heterojunction bipolar transistor (HBT) was investigated in static dc operation conditions. Multi-finger HBT structure was created using Sentaurus structure editor with dimensions similar to the layout of SiGe:C multi-finger HBTs in ST-Microelectronics BiCMOS55 (B55) technology (f T > 300 GHz, f max > 400 GHz) as per ST's BiCMOS55 process design kit guidelines. Three-dimensional thermal technology computer aided design (TCAD) simulations were carried out to obtain the temperature distribution in static dc operation. The lattice temperature (T Lattice) and heat flux (F Heat) distribution inside the device were studied. The impact of back-end-of-line (BEOL) layers on static thermal behavior of the state-of-the-art SiGe:C multi finger HBTs was also investigated. The temperature dependent thermal resistance of different fingers of the trench isolated SiGe multi-finger HBT was extracted without and with back-end-of-line (BEOL) effect. An electro-thermal dc compact model of self-heating and mutual thermal coupling in multi-finger HBTs was proposed and applied to compare the modeling results with the TCAD simulation results. Very good agreement was achieved between results obtained from TCAD simulation and those obtained from compact model-based simulation.

  20. Recruitment of mRNA-destabilizing protein TIS11 to stress granules is mediated by its zinc finger domain

    TIS11, a member of the CCCH zinc finger protein family, was found to be distributed throughout cells with a preferential cytoplasmic localization when transiently expressed in COS-7 cells. Upon treatment with heat shock, TIS11 became localized in discrete particles in the cytoplasm of the transfectants. We showed the TIS11-positive particles to be stress granules (SGs), which are known to be formed in the cytoplasm of eukaryotic cells in response to environmental stresses. By deletion studies using the green fluorescent protein fusion system, we mapped a functional stress granule (SG) localization signal to a region containing two tandem repeats of the zinc finger motif of TIS11. Site-directed mutations of Tyr105/Tyr113, Gly109/Gly 114, and Phe119 in the first zinc finger motif diminished the ability of this TIS11 domain to direct SG localization. Importantly, when the zinc-chelating Cys residues in either the first or second zinc finger were mutated to Ala residues, the recruitment of the TIS11 zinc finger region to SG was significantly inhibited by the mutation and was completely abolished by the mutation in both zinc fingers. These results suggest that recruitment of TIS11 to heat shock-induced SG is governed by the tandem zinc finger domains of this protein