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Sample records for 5p governance strategy

  1. 76 FR 29195 - National Strategy for Trusted Identities in Cyberspace (NSTIC) Governance Workshop

    2011-05-20

    ... National Institute of Standards and Technology National Strategy for Trusted Identities in Cyberspace... Cyberspace (NSTIC) Governance Workshop to be held on Thursday, June 9, 2011, 9 a.m. until 5 p.m. and Friday.... DATES: The National Strategy for Trusted Identities in Cyberspace (NSTIC) Governance Workshop will...

  2. HUD Digital Government Strategy Report

    Department of Housing and Urban Development — The HUD Digital Strategic Plan clearly articulates the goals of openness and transparency, furthering the innovation economy and meeting more global government wide...

  3. Governing urban finance: changing budgetary strategies in British local government

    P L Pinch

    1995-01-01

    The restructuring of local government finance in Britain is increasingly being viewed as part and parcel of a broader transformation in the capacity for local welfare provision and scope of local governance. The ways in which local authority budgetary processes and strategies have been affected by these changes are examined. It is suggested that, despite strong elements of continuity, significant new developments in local budgeting behaviour are emerging. However, such changes are not univers...

  4. Emerging Strategies for Private-Sector Governance.

    Gibson, Cristina

    This report delineates five governance strategies in U.S. corporations that have emerged over the last 20 years: (1) reform of corporate boards, which includes the role of boards and implementation approaches; (2) organizational improvement, which details employee involvement, total quality management, and reengineering; (3) developing team-based…

  5. Innovative Governance Strategies in Meetings Destination Networks

    Gyimóthy, Szilvia; Larson, Mia

    2013-01-01

    the bureaucratic culture of public administration and the marketing culture adopted by private tourism firms (Palmer 1996). This regional coordinating role must be undertaken in spite of limited ownership, budget or power to control how individual firms deliver (D’Angella & Go 2007). Furthermore, various actors...... Organisations (DMOs). These conditions lead to ambiguity and conflicts regarding strategic planning, authoritative decision making, development of a clear destination brand identity and unanimous support during destination brand delivery. Lacking the predictability of corporate organisational structures, DMOs...... on a comparative analysis of Convention Bureaus (CVBs) and the network around them in the two cities, the study sheds light on governance strategies adopted by the convenors in order to mobilize meetings industry stakeholders across cultural, institutional and political borders. Conceptual approach The theoretical...

  6. How does Corporate Governance Affect Bank Capitalization Strategies?

    Anginer, D.; Demirgüc-Kunt, A.; Huizinga, H.P.; Ma, K.

    2013-01-01

    Abstract: This paper examines how corporate governance and executive compensation affect bank capitalization strategies for an international sample of banks over the 2003-2011 period. ‘Good’ corporate governance, which favors shareholder interests, is found to give rise to lower bank capitalization.

  7. How does corporate governance affect bank capitalization strategies?

    Anginer, D.; Demirgüç-Kunt, A.; Huizinga, Harry; Ma, K.

    2016-01-01

    This paper examines how corporate governance and executive compensation affect bank capitalization strategies for an international sample of banks over the 2003-2011 period. ‘Good’ corporate governance, which favors shareholder interests, is found to give rise to lower bank capitalization. Boards of

  8. Tax Limitations and Revenue Shifting Strategies in Local Government

    Blom-Hansen, Jens; Bækgaard, Martin; Serritzlew, Søren

    2014-01-01

    The literature on tax and expenditure limitations (TELs) shows how limiting the freedom of local governments to levy taxes may have considerable unexpected effects. Entities subjected to such limitations may, as their proponents hope, react by cutting expenditures and revenue, but they may also...... strategically change their revenue structure and increase reliance on income sources not subjected to limitations. However, these findings are overwhelmingly based on studies of state and local governments in the USA. Their relevance outside this empirical setting remains unclear. A study of Denmark, where the...... subjected to tax limitations employ revenue-shifting strategies. In Denmark, however, these strategies are contingent on the specifics of the Danish intergovernmental system, which render central government grants an attractive object of revenue-shifting strategies. Our analysis thus helps identify the...

  9. REDD+ policy strategy in Cameroon: Actors, institutions and governance

    Somorin, O.A.; Visseren-Hamakers, I.J.; Arts, B.J.M.; Sonwa, D.J.; Tiani, A.

    2014-01-01

    Reducing emissions from deforestation and forest degradation (REDD+) is receiving increasing political and scientific attention as a climate change mitigation approach. The government of Cameroon has expressed an interest in participating in REDD+, and national deliberation on a policy strategy has

  10. Sustainable Development Strategy: A Tool for Strategic Governance?

    Zuzana Drhová

    2011-12-01

    Full Text Available In a historical overview, the preparation process of the Sustainable Development Strategy in the Czech Republic is illustrated as continuous learning by all stakeholders, on the one hand, facing institutional and personal limits of public administration’s capacity for strategic governance, on the other hand. The main positive output of preparing the SDS in the Czech Republic has been the strengthening of the institutional and individual capacities for strategic governance among all involved stakeholders (including ministries. These capacities are then applied in agendas such as the cohesion policy and preparation of the National Strategic Framework 2014–2020.

  11. Government Open Systems Interconnection Profile (GOSIP) transition strategy

    Laxen, Mark R.

    1993-09-01

    This thesis analyzes the Government Open Systems Interconnection Profile (GOSIP) and the requirements of the Federal Information Processing Standard (FIPS) Publication 146-1. It begins by examining the International Organization for Standardization (ISO) Open Systems Interconnection (OSI) architecture and protocol suites and the distinctions between GOSIP version one and two. Additionally, it explores some of the GOSIP protocol details and discusses the process by which standards organizations have developed their recommendations. Implementation considerations from both government and vendor perspectives illustrate the barriers and requirements faced by information systems managers, as well as basic transition strategies. The result of this thesis is to show a transition strategy through an extended and coordinated period of coexistence due to extensive legacy systems and GOSIP product unavailability. Recommendations for GOSIP protocol standards to include capabilities outside the OSI model are also presented.

  12. National climate strategy. Finland. Government report to Parliament

    At the session held in Kyoto in 1997, the Parties to the Climate Convention agreed on legally binding targets for reducing greenhouse gas emissions. Under the so- called Kyoto Protocol, the Member States of the European Community and the European Union shall reduce their annual emissions by eight per cent annually during the years 2008-2012 compared to the 1990 level. Within the Community, the targets have been allotted among the Member States so that Finland's annual greenhouse gas emissions may amount on average to no more than the 1990 level during the commitment period 2008-2012. This National Climate Strategy, submitted to Parliament in the form of a Government report, contains the principles, targets and measures that the Government finds necessary in order to meet our national target. The background material for the strategy consists of sector-specific reports made by the various ministries. The ministerial working group has coordinated the preparation of the strategy. For the strategy, the ministries have carried out and commissioned numerous separate analyses and studies, the reports of which have been published in the course of preparing the strategy. Based on these end the sector-specific reports, a background report to the National Climate Programme entitled 'The Need for and Possibilities of Reducing Greenhouse Gas Emissions in Finland' was compiled for the ministerial working group. The report was co-ordinated by the Kyoto contact network composed of civil servants from the various ministries. The report describes in more detail the factors influencing economic growth, energy consumption and production, and other elements affecting the development of greenhouse gases, which were used as underlying assumptions when determining the recommendations for action under the strategy. The economic and other effects of alternative courses of action were also analysed and described in the above-mentioned background study. It has been published in the Internet on

  13. Autoimmune diagnostics: the technology, the strategy and the clinical governance.

    Bizzaro, Nicola; Tozzoli, Renato; Villalta, Danilo

    2015-02-01

    In recent years, there has been a profound change in autoimmune diagnostics. From long, tiring and inaccurate manual methods, the art of diagnostics has turned to modern, rapid and automated technology. New antibody tests have been developed, and almost all autoimmune diseases now have some specific diagnostic markers. The current need to make the most of available economic and human resources has led to the production of diagnostic algorithms and guidelines designated for optimal strategic use of the tests and to increase the diagnostic appropriateness. An important role in this scenario was assumed by the laboratory autoimmunologist, whose task is not only to govern the analytical phase, but also to help clinicians in correctly choosing the most suitable test for each clinical situation and provide consultancy support. In this review, we summarize recent advances in technology, describe the diagnostic strategies and highlight the current role of the laboratory autoimmunologist in the clinical governance of autoimmune diagnostics. PMID:25398640

  14. Regional governance: strategies and disputes in health region management

    dos Santos, Adriano Maia; Giovanella, Ligia

    2014-01-01

    OBJECTIVE To analyze the regional governance of the health systemin relation to management strategies and disputes. METHODOLOGICAL PROCEDURES A qualitative study with health managers from 19 municipalities in the health region of Bahia, Northeastern Brazil. Data were drawn from 17 semi-structured interviews of state, regional, and municipal health policymakers and managers; a focus group; observations of the regional interagency committee; and documents in 2012. The political-institutional and the organizational components were analyzed in the light of dialectical hermeneutics. RESULTS The regional interagency committee is the chief regional governance strategy/component and functions as a strategic tool for strengthening governance. It brings together a diversity of members responsible for decision making in the healthcare territories, who need to negotiate the allocation of funding and the distribution of facilities for common use in the region. The high turnover of health secretaries, their lack of autonomy from the local executive decisions, inadequate technical training to exercise their function, and the influence of party politics on decision making stand as obstacles to the regional interagency committee’s permeability to social demands. Funding is insufficient to enable the fulfillment of the officially integrated agreed-upon program or to boost public supply by the system, requiring that public managers procure services from the private market at values higher than the national health service price schedule (Brazilian Unified Health System Table). The study determined that “facilitators” under contract to health departments accelerated access to specialized (diagnostic, therapeutic and/or surgical) services in other municipalities by direct payment to physicians for procedure costs already covered by the Brazilian Unified Health System. CONCLUSIONS The characteristics identified a regionalized system with a conflictive pattern of governance and

  15. Regional governance: strategies and disputes in health region management

    Adriano Maia dos Santos

    2014-08-01

    Full Text Available OBJECTIVE To analyze the regional governance of the health systemin relation to management strategies and disputes. METHODOLOGICAL PROCEDURES A qualitative study with health managers from 19 municipalities in the health region of Bahia, Northeastern Brazil. Data were drawn from 17 semi-structured interviews of state, regional, and municipal health policymakers and managers; a focus group; observations of the regional interagency committee; and documents in 2012. The political-institutional and the organizational components were analyzed in the light of dialectical hermeneutics. RESULTS The regional interagency committee is the chief regional governance strategy/component and functions as a strategic tool for strengthening governance. It brings together a diversity of members responsible for decision making in the healthcare territories, who need to negotiate the allocation of funding and the distribution of facilities for common use in the region. The high turnover of health secretaries, their lack of autonomy from the local executive decisions, inadequate technical training to exercise their function, and the influence of party politics on decision making stand as obstacles to the regional interagency committee’s permeability to social demands. Funding is insufficient to enable the fulfillment of the officially integrated agreed-upon program or to boost public supply by the system, requiring that public managers procure services from the private market at values higher than the national health service price schedule (Brazilian Unified Health System Table. The study determined that “facilitators” under contract to health departments accelerated access to specialized (diagnostic, therapeutic and/or surgical services in other municipalities by direct payment to physicians for procedure costs already covered by the Brazilian Unified Health System. CONCLUSIONS The characteristics identified a regionalized system with a conflictive pattern of

  16. 2004 Rose Site 5P

    US Fish and Wildlife Service, Department of the Interior — Underwater Site 5P was established off Rose Atoll, American Samoa by Dr. James Maragos, U.S. Fish & Wildlife Service, on February 20, 2002. With a start point...

  17. 2002 Rose Site 5P

    US Fish and Wildlife Service, Department of the Interior — Underwater Site 5P was established off Rose Atoll, American Samoa by Dr. James Maragos, U.S. Fish & Wildlife Service, on February 20, 2002. With a start point...

  18. 2000 Johnston Site 5P

    US Fish and Wildlife Service, Department of the Interior — Underwater Site 5P was established at Johnston Atoll by Dr. James Maragos, U.S. Fish & Wildlife Service, on July 2, 2000. With a start point (meter 0) at...

  19. Adaptive governance and institutional strategies for climate-induced community relocations in Alaska

    Bronen, Robin; Chapin, F Stuart

    2013-01-01

    This article presents governance and institutional strategies for climate-induced community relocations. In Alaska, repeated extreme weather events coupled with climate change-induced coastal erosion impact the habitability of entire communities. Community residents and government agencies concur that relocation is the only adaptation strategy that can protect lives and infrastructure. Community relocation stretches the financial and institutional capacity of existing governance institutions....

  20. Research on the Relationship among Government Regulations, Strategy Preference and Manufacturing Performance

    Wei Wang,; Fa-Xin Cheng

    2012-01-01

    Based on the environment-strategy-performance paradigm, the paper constructs a theoretical framework on the rela- tionship among government regulations, manufacturing strategy and performance. Using structural equation model and a sample of 135 SME of Jiangsu Province, this paper examines the relationship among government regulations, manu- facturing strategy and performance, the result of which shows that government regulations have a significant positive effect on cost, quality and innovati...

  1. The Flexible Management Strategy of E-Government

    Xiaohe Yu

    2013-04-01

    Full Text Available In reaction to the phenomenon that the social demand varies rapidly along with the difficulty in the perfection of e-government system in one step in the course of the construction of E-government in China; the goal of the establishment of flexible e-government system should be achieved by means of the flexible reforms both on the government structure and administration mode.

  2. What Is Green Growth Strategy for Government Link Company?

    Jamilah Asha’ari, Maryam; Daud, Salina; Hassan, Hasmaizan

    2016-03-01

    Disasters around the world are very extreme because of the global warming and climate change. Malaysia firms have to play their role in handling the challenging of environmental problems in order to sustain. The feature of the new strategy which is green growth strategy has been identified. The study focuses on the features of the green growth strategy which discuss on the keys to sustaining the strategy, marketing emphasis, production emphasis, product line, basis of competitive advantage and strategic target. Business had contributed to the industrialisation era positively or negatively and therefore there is a must for business people to use the best strategy in reducing the environmental risks. By 2020, Malaysia will achieve the target in becoming an advanced economy by applying the right strategy. The objective of this paper is to propose a feature for new strategy known as green growth strategy. Future study is to propose to conduct an empirical analysis to confirm the green growth strategy features.

  3. The new government strategy for higher education in the Netherlands: an analysis

    Vught, van F.A.

    1989-01-01

    In the Netherlands a new government strategy for higher education is emerging. This new strategy is presented by the Ministry of Education and Science as a development of more institutional self-regulation and a distancing of government from day to day higher education affairs. This article asks whe

  4. A New Fuzzy MCDM Framework to Evaluate E-Government Security Strategy

    Syamsuddin, Irfan

    2010-01-01

    Ensuring security of e-government applications and infrastructures is crucial to maintain trust among stakeholders to store, process and exchange information over the e-government systems. Due to dynamic and continuous threats on e-government information security, policy makers need to perform evaluation on existing information security strategy as to deliver trusted e-government services. This paper presents an information security evaluation framework based on new fuzzy multi criteria decision making (MCDM) to help policy makers conduct comprehensive assessment of e-government security strategy.

  5. The new government strategy for higher education in the Netherlands: an analysis

    Vught, van, F.A.

    1989-01-01

    In the Netherlands a new government strategy for higher education is emerging. This new strategy is presented by the Ministry of Education and Science as a development of more institutional self-regulation and a distancing of government from day to day higher education affairs. This article asks whether the Dutch Government is really allowing higher education institutions to become more autonomous. To answer this question two recent policy papers on higher education from the Ministry of Educa...

  6. Government Financial Management, Strategy for Preventing Corruption in Indonesia

    Haryono Umar

    2007-04-01

    Full Text Available In popular view, the term accountability generally refers to a wide spectrum of public expectations dealing with organizational performance, responsiveness, good governance, and even morality of government and nonprofit organizations. These expectations often include implicit performance criteria – related to obligations and responsibilities – that are subjectively interpreted and sometimes even contradictory. And in this broader conception of accountability, the range of people and institutions to whom public and nonprofit organizations must account include not only higher authorities in the institutional chain of command but also the general public, the news media, peer agencies, donors, and many other stakeholders (Kearns, 1996. Government could build its accountability by implementing good and proper financial management. Financial management is a tool for government to show its performance and accountability to the public. Meanwhile, corruption is the misuse of public office for private gain. As such, it involves the improper and unlawful behavior of public-service officials, both politicians and civil servants, whose positions create opportunities for the diversion of money and assets from government to them and their accomplices (Langseth, 1999. The more corruption, the more far away from good governance, and the less public accountability. According to Klitgaard (1988, power minus accountability is corruption. This paper explains about the influences of implementing government financial management to corruption fighting and good governance in broadly view. Discussion will be derived to find out the understanding of financial management, corruption, and good governance terminology fits for Indonesia environment. The purpose of this paper is to achieve common knowledge that financial management should be implemented by public organization from strategic management for public organization approaches. Besides, reader will find out

  7. Tissue Engineering Stem Cells – An e-Governance Strategy

    Grange, Simon

    2011-01-01

    The rules of governance are changing. They are necessarily becoming more stringent as interventions offered to treat conditions carry unpredictable side effects, often associated with novel therapeutic vectors. The clinical relevance of this relates to the obligations of those involved in research, to ensure the best protection for subjects whilst encouraging the development of the field. Existing evidence supports the concept of e-Governance both in operational health research and more broad...

  8. The strategies of governance from two perspectives: capitalist enterprises versus social economy enterprises: an empirical study

    María del Carmen Muñoz Medraño; Francisco Laborda Peñalver; Antonio Juan Briones Peñalver

    2014-01-01

    Companies increasingly develop strategies and implement governance models of efficient management. These systems of government are based on innovative measures, policies for social and environmental responsibility, and strategic alliances. All are being considered in recent years as efficient policies for the governance of institutions, creating value and better business results. This paper addresses good governance from a comparative analysis of capitalist enterprises and social economy to t...

  9. A New Fuzzy MCDM Framework to Evaluate E-Government Security Strategy

    Syamsuddin, Irfan; Hwang, Junseok

    2010-01-01

    Ensuring security of e-government applications and infrastructures is crucial to maintain trust among stakeholders to store, process and exchange information over the e-government systems. Due to dynamic and continuous threats on e-government information security, policy makers need to perform evaluation on existing information security strategy as to deliver trusted e-government services. This paper presents an information security evaluation framework based on new fuzzy multi criteria decis...

  10. The performance implications of strategic fit of relational norm governance strategies in global supply chain relationships

    Griffith, David A; Matthew B Myers

    2005-01-01

    The search for strategic fit has become a core concept in normative models of strategy formation. The issue of strategic fit is becoming increasingly important in global supply chain relationships as managers and academics examine the effectiveness of culturally founded relational governance strategies across multiple supply chain relationships. This study empirically examines the performance implications of strategic fit of relational norm governance strategies in global supply chain relatio...

  11. Public information strategies: Making government information available to citizens

    Meijer, A.J.; Thaens, M.

    2009-01-01

    New technological opportunities and increasing demands make it imperative for government agencies to make the information they gather available to citizens. How should they go about this? This paper presents a conceptual framework for analyzing the strategic options open to agencies which have information that could be relevant to citizens. The conceptual framework is constructed on the basis of the literature and tested in a case study. The Directorate-General for Public Works and Water Mana...

  12. A Brief Survey of Corporate Strategy, Environmental Issues and Corporate Governance at Vietnamese Companies

    Phung, Dinh Trong; Toma, Masayoshi

    2015-01-01

    So as to make a cursory investigation into corporate strategies, care about environmental issues and managerial forms (corporate governance) in business of current Vietnamese companies, a brief survey has conducted at 4 enterprises in Vietnam.

  13. Effects of Post-Privatization Governance and Strategies on Export Intensity in the Former Soviet Union

    Igor Filatotchev; Natalya Dyomina; Mike Wright; Trevor Buck

    2001-01-01

    The fall of the Soviet Union brought new enterprise opportunities whose exploitation required the development of entirely new strategies. Simultaneously, enterprises faced crucial constraints in their governance structures. This paper analyzes the impact of governance structures of privatized firms on one key outcome of new strategies: export intensity. Using a longitudinal, multi-industry dataset of privatized firms in Russia, Ukraine and Belarus, we analyze how export intensity is mediated ...

  14. Governing board structure, business strategy, and performance of acute care hospitals: a contingency perspective.

    Young, G; Beekun, R I; Ginn, G O

    1992-01-01

    Contingency theory suggests that for a hospital governing board to be effective in taking on a more active role in strategic management, the board needs to be structured to complement the overall strategy of the organization. A survey study was conducted to examine the strategies of acute care hospitals as related to the structural characteristics of their governing boards. After controlling for organizational size and system membership, results indicated a significant relationship between th...

  15. Green Grades: The Popularity and Perceived Effectiveness of Information-Based Environmental Governance Strategies

    Bullock, Graham Daniel

    2011-01-01

    Initiatives that use information to catalyze collective action have proliferated in recent years, and represent a significant shift away from more traditional governance strategies, such as regulation. This dissertation analyzes this phenomenon of "information-based governance" in the context of the environmental arena, where non-profit organizations, government agencies, and companies have developed a wide range of product eco-labels and corporate sustainability ratings to evaluate the envi...

  16. Organisational strategies for changing clinical practice: how trusts are meeting the challenges of clinical governance

    Wallace, L.; Freeman, T.; Latham, L; Walshe, K; Spurgeon, P

    2001-01-01

    Objectives—To describe the use, perceived effectiveness, and predicted future use of organisational strategies for influencing clinicians' behaviour in the approach of NHS trusts to clinical governance, and to ascertain the perceived benefits of clinical governance and the barriers to change.

  17. Let-7i-5p represses brite adipocyte function in mice and humans.

    Giroud, Maude; Karbiener, Michael; Pisani, Didier F; Ghandour, Rayane A; Beranger, Guillaume E; Niemi, Tarja; Taittonen, Markku; Nuutila, Pirjo; Virtanen, Kirsi A; Langin, Dominique; Scheideler, Marcel; Amri, Ez-Zoubir

    2016-01-01

    In response to cold or β3-adrenoreceptor stimulation brown adipose tissue (BAT) promotes non-shivering thermogenesis, leading to energy dissipation. BAT has long been thought to be absent or scarce in adult humans. The recent discovery of thermogenic brite/beige adipocytes has opened the way to development of novel innovative strategies to combat overweight/obesity and associated diseases. Thus it is of great interest to identify regulatory factors that govern the brite adipogenic program. Here, we carried out global microRNA (miRNA) expression profiling on human adipocytes to identify miRNAs that are regulated upon the conversion from white to brite adipocytes. Among the miRNAs that were differentially expressed, we found that Let-7i-5p was down regulated in brite adipocytes. A detailed analysis of the Let-7i-5p levels showed an inverse expression of UCP1 in murine and human brite adipocytes both in vivo and in vitro. Functional studies with Let-7i-5p mimic in human brite adipocytes in vitro revealed a decrease in the expression of UCP1 and in the oxygen consumption rate. Moreover, the Let-7i-5p mimic when injected into murine sub-cutaneous white adipose tissue inhibited partially β3-adrenergic activation of the browning process. These results suggest that the miRNAs Let-7i-5p participates in the recruitment and the function of brite adipocytes. PMID:27345691

  18. The strategies of governance from two perspectives: capitalist enterprises versus social economy enterprises: an empirical study

    María del Carmen Muñoz Medraño

    2014-05-01

    Full Text Available Companies increasingly develop strategies and implement governance models of efficient management. These systems of government are based on innovative measures, policies for social and environmental responsibility, and strategic alliances. All are being considered in recent years as efficient policies for the governance of institutions, creating value and better business results. This paper addresses good governance from a comparative analysis of capitalist enterprises and social economy to the region of Murcia. Transparency, democratic management, innovation, partnerships, among others, can make the difference between the modus operandi of these businesses and the effects thereof in the territories where they settle.

  19. Gender Differences in the Attitude and Strategy towards Weight Control among Government Employees in Penang, Malaysia

    Zaitun, Y; MT, Mohd Nasir; AS Hazizi; Aina Mardiah, B; JM, Hamid Jan

    2012-01-01

    "nBackground: This was a cross-sectional study on the gender differences in weight-control behavior. The strategies used, weight status, weight satisfaction, and proportion of individuals attempting to lose weight among 233 government employees (104 men and 129 women) working in the Federal Government Building in Penang, Malaysia, were assessed."nMethods: Anthropometric indicators such as body mass index, waist-to-hip ratio, and body fat percentage were measured to determine the sub...

  20. Gender Differences in the Attitude and Strategy towards Weight Control among Government Employees in Penang, Malaysia

    Aina Mardiah, B; Hazizi, AS; Nasir, MT Mohd; Zaitun, Y; Jan, JM Hamid

    2012-01-01

    Background: This was a cross-sectional study on the gender differences in weight-control behavior. The strategies used, weight status, weight satisfaction, and proportion of individuals attempting to lose weight among 233 government employees (104 men and 129 women) working in the Federal Government Building in Penang, Malaysia, were assessed. Methods: Anthropometric indicators such as body mass index, waist-to-hip ratio, and body fat percentage were measured to determine the subjects’ body w...

  1. How Corporate Governance Affects Strategy of Corporations : - Lessons from Enron Corporation -

    Ahmed, Hameed; Najam, Ali

    2006-01-01

    Corporate governance is a subject of academic and professional debate. It has and it will continue to be a topic under scrutiny for subsequent deliberations since there are many different research dimensions and contexts associated with it. However, it has been observed that the linkage between corporate governance and strategy of a corporation remains as an untapped area with considerable avenues of research. This paper tends to explore this linkage, using Enron scandal as backdrop. In the a...

  2. Contextual Factors Affecting E-Government Strategy Implementation and Its Impact on Public Sector Performance in Kenya

    Dr. James Gathungu; Alfred N. Mungai

    2013-01-01

    This paper assesses the contextual factors affecting the implementation of e-government strategy and its impact on the performance of the public sector in Kenya using the Wing Lam, (2005) E-government Integration Model. Electronic government (E-government) is viewed in this study as the utilization of Information Communication Technologies (ICTs) to transform the efficiency, effectiveness, transparency and accountability of exchanges within government, between government and citizens and busi...

  3. Developing a Medium-Term Debt-Management Strategy for the Government of Canada

    Marc Larson; Étienne Lessard

    2011-01-01

    As the Government of Canada’s fiscal agent, the Bank of Canada provides strategic policy advice on the management of the government’s debt, in addition to being responsible for conducting debt-management operations. In this article, the authors review the evolution of the debt strategy over the past 20 years and outline the complex process of developing a sound strategy that balances various cost and risk considerations. This includes an examination of the tools and practices used to develop ...

  4. The use of Enterprise Architecture, IT Strategy and IT Governance at StatoilHydro

    Parmo, Christopher Ludt

    2009-01-01

    The master thesis will extend the students depth study. Through the master thesis the student shall study and evaluate how IT Governance, Enterprise Architecture and IT Strategy are related in StatoilHydro. The student shall also research StatoilHydro´s awareness of the concepts. The student shall propose improvements and/or changes based on this evaluation.

  5. Conflict Resolution Strategies in Non-Government Secondary Schools in Benue State, Nigeria

    Oboegbulem, Angie; Alfa, Idoko Alphonusu

    2013-01-01

    This study investigated perceived CRSs (conflict resolution strategies) for the resolution of conflicts in non-government secondary schools in Benue State, Nigeria. Three research questions and three hypotheses guided this study. Proportionate stratified random sampling technique was used in drawing 15% of the population which gave a total of 500…

  6. Governance of sustainable development: co-evolution of corporate and political strategies

    This article proposes a policy framework for analysing corporate governance toward sustainable development. The aim is to set up a framework for analysing market evolution toward sustainability. In the first section, the paper briefly refers to recent theories about both market and government failures that express scepticism about the way that framework conditions for market actors are set. For this reason, multi-layered governance structures seem advantageous if new solutions are to be developed in policy areas concerned with long-term change and stepwise internalisation of externalities. The paper introduces the principle of regulated self-regulation. With regard to corporate actors' interests, it presents recent insights from theories about the knowledge-based firm, where the creation of new knowledge is based on the absorption of societal views. The result is greater scope for the endogenous internalisation of externalities, which leads to a variety of new and different corporate strategies. Because governance has to set incentives for quite a diverse set of actors in their daily operations, the paper finally discusses innovation-inducing regulation. In both areas, regulated self-regulation and innovation-inducing regulation, corporate and political governance co-evolve. The paper concludes that these co-evolutionary mechanisms may assume some of the stabilising and orientating functions previously exercised by framing activities of the state. In such a view, the government's main function is to facilitate learning processes, thus departing from the state's function as known from welfare economics. (author)

  7. PLANNING THE IMPLEMENTATION OF QUALITY THROUGH STRATEGY FORMULATION AND CORPORATE GOVERNANCE

    Nikola Stefanović

    2007-09-01

    Full Text Available Planning the implementation of quality is a complex process that depends on many different internal and external factors. Planning the implementation is defined by the capabilities of management to visualize the market position of the company and to evaluate the company's strengths, weaknesses, opportunities, and threats. Serving to the company's purposes, planning the implementation of quality must be integrated into the company's strategic objectives and then transferred to other parts of the organization utilizing the corporate governance system. Planning the implementation, as a part of strategy formulation, should be reflected in: 1 company's vision and mission development, 2 goals setting, 3 strategy development aimed at achieving goals, 4 implementation and execution of the strategy, and 4 monitoring, evaluation, control, and readjustment of the strategy. Finally, planning must account for all possible implementation barriers.

  8. Demands for media democratisation and the Latin American 'New Left': Government strategies in Argentina and Brazil in comparative perspective

    Kitzberger, Philip

    2014-01-01

    This paper examines the determinants of government strategies vis-à-vis dominant media actors in the Latin American context, where the media’s role in democratic politics is increasingly being questioned. It compares the first two Kirchnerist presidencies in Argentina with the first two Workers’ Party-led governments in Brazil. While these governments initially adopted accommodation strategies towards media organisations, political crises subsequently disturbed the fragile coexistence of medi...

  9. Adaptive governance and institutional strategies for climate-induced community relocations in Alaska.

    Bronen, Robin; Chapin, F Stuart

    2013-06-01

    This article presents governance and institutional strategies for climate-induced community relocations. In Alaska, repeated extreme weather events coupled with climate change-induced coastal erosion impact the habitability of entire communities. Community residents and government agencies concur that relocation is the only adaptation strategy that can protect lives and infrastructure. Community relocation stretches the financial and institutional capacity of existing governance institutions. Based on a comparative analysis of three Alaskan communities, Kivalina, Newtok, and Shishmaref, which have chosen to relocate, we examine the institutional constraints to relocation in the United States. We identify policy changes and components of a toolkit that can facilitate community-based adaptation when environmental events threaten people's lives and protection in place is not possible. Policy changes include amendment of the Stafford Act to include gradual geophysical processes, such as erosion, in the statutory definition of disaster and the creation of an adaptive governance framework to allow communities a continuum of responses from protection in place to community relocation. Key components of the toolkit are local leadership and integration of social and ecological well-being into adaptation planning. PMID:23690592

  10. Relationship between Marketing Strategies and Governance Mechanisms: A Study in Exploration Chain Beef Cattle

    Filipe Quevedo-Silva

    2015-09-01

    Full Text Available The relationship between actors has been unspoilt by marketing through the bias of Transaction Costs Economics. Some authors suggest that a marketing strategy can directly impact the transactional characteristics and hence the governance mechanisms chosen to coordinate transactions. Studies suggest that future work in the field of marketing include, among other factors, aspects related to the relationship between the actors. In this context, this article aims to analyze how marketing strategies can affect the choice of governance mechanisms. The study object is the chain of beef, view their representation to the national economy. To this end, we conducted a qualitative study using semi-structured interviews with various actors in the chain. It was possible to verify the existence of the relationship between marketing strategy and governance structure. In one of the cases, product differentiation, translated into more specific assets, led the producer to perform a relational contract with the fridge and to distribute your product, make an integration with retailers, through the opening of a boutique of meat. Factor that was not observed in transactions involving producers on products without distinction, for which the transactions via spot market are prevalent.  

  11. Priorities in national space strategies and governance of the member states of the European Space Agency

    Adriaensen, Maarten; Giannopapa, Christina; Sagath, Daniel; Papastefanou, Anastasia

    2015-12-01

    The European Space Agency (ESA) has twenty Member States with a variety of strategic priorities and governance structures regarding their space activities. A number of countries engage in space activities exclusively though ESA, while others have also their own national space programme. Some consider ESA as their prime space agency and others have additionally their own national agency with respective programmes. The main objective of this paper is to provide an up-to date overview and a holistic assessment of strategic priorities and the national space governance structures in 20 ESA Member States. This analysis and assessment has been conducted by analysing the Member States public documents, information provided at ESA workshop on this topic and though unstructured interviews. The paper is structured to include two main elements: priorities and trends in national space strategies and space governance in ESA Member States. The first part of this paper focuses on the content and analysis of the national space strategies and indicates the main priorities and trends in Member States. The priorities are categorised with regards to technology domains, the role of space in the areas of sustainability and the motivators that boost engagement in space. These vary from one Member State to another and include with different levels of engagement in technology domains amongst others: science and exploration, navigation, Earth observation, human space flight, launchers, telecommunications, and integrated applications. Member States allocate a different role of space as enabling tool adding to the advancement of sustainability areas including: security, resources, environment and climate change, transport and communication, energy, and knowledge and education. The motivators motivating reasoning which enhances or hinders space engagement also differs. The motivators identified are industrial competitiveness, job creation, technology development and transfer, social benefits

  12. Implications of the Ontario government's white paper and competition strategies for Ontario's municipal electric utilities

    The strategies that Municipal Electric Utilities (MEU) should follow to deal with competition were discussed. North Bay Hydro is the 34th largest MEU out of 300 in Ontario but it serves only 23,000 out of 4 million electrical customers in Ontario. Therefore, the main strategy for municipal utilities to ensure their future would be to become part of an alliance and association like the MEA and the SAC - the Strategic Alliance for Competition and Customer Choice. Strong criticism was voiced regarding the contents of the recent Ontario Government White Paper for being vague with regard to electrical distribution and the role of MEUs in Ontario. It was suggested that it is vitally important that MEUs ally themselves with other stakeholders, to resist an Ontario Hydro monopoly, to make sure that prices stay low, to avoid excessive debt and bureaucratic inefficiency, be innovative, and consumer oriented and be prepared to anticipate events and conditions. 3 figs

  13. THEORETIC INCURSION IN THE IDENTIFICATION OF DETERMINANTS AND E-GOVERNMENT STRATEGY. EMPIRIC STUDY OVER THE GRADE OF IMPLEMENTATION OF E-GOVERNMENT IN BIHOR COUNTY

    Pop Cohut Ioana

    2012-07-01

    Full Text Available We are currently witnessing an unprecedented development of new technologies, that offers great opportunities for the modernization of the society, it changes radically the way governments, businesses and citizens have the opportunity to obtain goods and services, the way in which public services are provided that become increasingly important for citizens, the way of obtaining and transmitting information, the way in which business connections are done, the interaction between different communities, etc.. From this point of view we research the way in which public strategies of achievement and implementation of model of e-government are shaped, model which can exploit the opportunities offered by new technologies and can implement roles for the citizen and public policy makers and implicitly of local and regional development. How the public sector should support the implementation of strategies of e-government, to polarize at the highest level all communities of interest, to provide a framework for planning and action across the board, covering local administration, institutions, organizations and government agencies, to empower appropriate training for implementation of IT strategies, can lead to stimulation of generators factors of local and regional development. We also, intend to identify, from carrying out an empirical study in Bihor county, by analysis of 30 public institutions, the degree of implementation of new technologies in public administration, human resources readiness for appropriate use of IT facilities and what level of implementation of e-government in these institutions, in order to outline the main characteristics and determinants of e-government implementation. The present paper is of interest to policy-makers, researchers, local communities through analysis how the introduction of new technology development in developing and implementing public policies, particularly by networking government and e-government, can cause

  14. Corporate Governance and Firm Performance: An Analysis of Ownership Structure, Profit Redistribution and Diversification Strategies of Firms in India.

    George, R.

    2005-01-01

    This dissertation examines the relationship between corporate governance and performance of firms in India. Utilizing various theoretical bases in strategy and finance domains, the dissertation attempts to distill a better understanding of the pivotal role played by the twin dimensions of ownership structure and business group-affiliation in influencing firm strategy and performance. In particular, three pertinent issues underpinning the corporate governance-firm performance relationship are ...

  15. Imperial or postcolonial governance? Dissecting the genealogy of a global public health strategy.

    Brown, Tim; Bell, Morag

    2008-11-01

    During the last decades of the 20th century it became increasingly apparent that the inter-relationship between globalisation and health is extremely complex. This complexity is highlighted in debates surrounding the re-emergence of infectious diseases, where it is recognised that the processes of globalisation have combined to create the conditions where once localised, microbial hazards have come to pose a threat to many western nations. By contrast, in an emerging literature relating to the epidemic of non-communicable diseases, and reflected in the WHO 'Global strategy on diet, physical activity and health', it is the so-called 'western lifestyle' that has been cast as the main threat to a population's health. This paper explores critically global responses to this development. Building on our interest in questions of governance and the ethical management of the healthy body, we examine whether the global strategy, in seeking to contain the influence of a 'western lifestyle', also promotes contemporary 'western-inspired' approaches to public health practices. The paper indicates that a partial reading of the WHO strategy suggests that certain countries, especially those outside the West, are being captured or 'enframed' by the integrative ambitions of a western 'imperial' vision of global health. However, when interpreted critically through a postcolonial lens, we argue that 'integration' is more complex, and that the subtle and dynamic relations of power that exist between countries of the West/non-West, are exposed. PMID:18771835

  16. Brazilian Constitution: The concept of family and family planning as a government strategy

    Helena Beatriz Kochenborger Scarparo

    2015-07-01

    Full Text Available In this paper we approached a study about the legal contexts of the Brazilian Constitution which we find the notion of family and family planning, as well as the laws regarding family planning that were promulgated after the 1988 Constitution. Guided through the Foucault’s perspective we questioning how the rationalities that underlie such legislations may produce effects in the organization and management of the population nowadays. We selected the material analyzed through systematic research in the Brazilian Constitution and in the Portal of Legislation of the Presidency of Brazil. The results obtained indicate that the idea of family and family planning compose legal tools which constitute elements of retrenchment and disciplining of subjects by regulations that they establish. Thus, the jurisdictions operate as strategies to the Brazilian government that include goals that put the employment as the base of everything, and from this, directs people through the policies that produce.

  17. Climate change in semi-arid Malawi: Perceptions, adaptation strategies and water governance

    Miriam K. Joshua

    2016-03-01

    Full Text Available Climate change and variability are a threat to sustainable agricultural production in semi-arid areas of Malawi. Overdependence on subsistence rain-fed agriculture in these areas calls for the identification of sustainable adaptation strategies. A study was therefore conducted in Chikwawa, a semi-arid district in southern Malawi, to: (1 assess community’s perception of a changing climate against empirical evidence, (2 determine their local adaptive measures, (3 evaluate the potential of irrigated agriculture as an adaptive measure in household food security and (4 challenges over access to available water resources. The study employed focus group discussions and key informant interviews to assess people’s perceptions of climate change and variability and their desired interventions. To validate the people’s perceptions, rainfall and temperature data for the period 1960–2010 were analysed. A participatory complete randomised experimental design in both rain-fed and dry season–irrigated conditions was conducted to assess a maize cropping system that would improve adaptation. The study established persistent declining yields from rain-fed production in part because of perennial rainfall failure. In response, the community has shifted its focus to irrigation as an adaptation strategy, which has in turn triggered water conflicts in the community over the control of the resource. Water legislation however fails to adequately provide for rules governing sharing of water resources between various stakeholders. This article therefore recommends development of an appropriate institutional framework that forms a strong basis for equitable distribution of water for irrigation in areas most vulnerable to extreme climate events – including droughts and floods.Keywords: Food Security; Climate Change and Variability; Rainfall Variability; Irrigation; Water Resources; Governance Crisis

  18. Contextual Factors Affecting E-Government Strategy Implementation and Its Impact on Public Sector Performance in Kenya

    Dr. James Gathungu

    2013-06-01

    Full Text Available This paper assesses the contextual factors affecting the implementation of e-government strategy and its impact on the performance of the public sector in Kenya using the Wing Lam, (2005 E-government Integration Model. Electronic government (E-government is viewed in this study as the utilization of Information Communication Technologies (ICTs to transform the efficiency, effectiveness, transparency and accountability of exchanges within government, between government and citizens and businesses locally and abroad; and to empower citizens through access and use of information. Although e-government is a rapidly growing concept in both developing and developed countries very few e-government initiatives progress to maturity. Different countries are faced with different contextual circumstances and environments in the realization of e-government initiatives. This study attempts to address the gap between theory and rhetoric about the potential of e-government and the reality of its application on the ground in Kenya. The study attempts to analyze the philosophy, theories and paradigms of e-government. The development of the commercial concept as a new paradigm in public administration replacing the traditional bureaucratic systems of government is highlighted in the study. A detailed conceptual discussion anchors the study on the Wing Lam, (2005 E-government Integration Model (EGI basing it on the Kenyan perspective. The study also reviews relevant e-government studies from an international, regional and local perspective anchoring the study on the configuration school of management thought. These discussions are used to develop new insights in view of the emerging issues and their relevance to the public sector in Kenya.  

  19. Local energy governance in vermont: an analysis of energy system transition strategies and actor capacity

    Rowse, Tarah

    While global, national, and regional efforts to address climate and energy challenges remain essential, local governments and community groups are playing an increasingly stronger and vital role. As an active state in energy system policy, planning and innovation, Vermont offers a testing ground for research into energy governance at the local level. A baseline understanding of the energy planning and energy organizing activities initiated at the local level can support efforts to foster a transition to a sustainable energy system in Vermont. Following an inductive, applied and participatory approach, and grounded in the fields of sustainability transitions, energy planning, and community energy, this research project identifies conditions for change, including opportunities and challenges, within Vermont energy system decision-making and governance at the local level. The following questions are posed: What are the main opportunities and challenges for sustainable energy development at the town level? How are towns approaching energy planning? What are the triggers that will facilitate a faster transition to alternative energy systems, energy efficiency initiatives, and localized approaches? In an effort to answer these questions two studies were conducted: 1) an analysis of municipal energy plans, and 2) a survey of local energy actors. Study 1 examined Vermont energy planning at the state and local level through a review and comparison of 40 municipal plan energy chapters with the state 2011 Comprehensive Energy Plan. On average, municipal plans mentioned just over half of the 24 high-level strategies identified in the Comprehensive Energy Plan. Areas of strong and weak agreement were examined. Increased state and regional interaction with municipal energy planners would support more holistic and coordinated energy planning. The study concludes that while municipalities are keenly aware of the importance of education and partnerships, stronger policy mechanisms

  20. Deregulation strategies for local governments and the role/opportunities for energy efficiency services in the utility industry deregulation

    As the future shape of the electric utility industry continues to unfold and as retail competition becomes a reality, local governments are faced with balancing the need for: (1) economic development; (2) and to avoid the potential impact of cost-shifting among residents and businesses, while ensuring reliable and universal energy services. Furthermore, local governments need to find ways to recoup potential loss of franchise and tax revenues, to ensure fair and adequate energy-efficiency programs, and to continue other social programs for low income families. This paper will address two important issues every local government in the US are facing: (1) the development of viable deregulation strategies before, during and after the promulgation of utility deregulation; (2) opportunities for energy efficiency services in the competitive markets to serve local governments, which typically constitutes the largest market segment in utility's service territory. This paper presents issues and challenges common to all local governments. It documents strategies that several local governments are utilizing to embrace the coming electric utility restructuring and competition challenge to the benefits of their respective communities. This paper presents the results on deregulation work by the City of Portland, Oregon, Barnstable County, Massachusetts, and Montgomery County, Maryland. The research by these local governments was sponsored by the Urban Consortium Energy Task Force and Public Technology, Inc

  1. Mir-434-5p mediates skin whitening and lightening

    David TS Wu

    2008-10-01

    Full Text Available David TS Wu, Jack S Chen, Donald C Chang, Shi-Lung LinInstitute of Mello Biotechnology, Taipei, Taiwan, ROCAbstract: Utilization of gene silencing effectors, such as microRNA (miRNA and small airpin RNA (shRNA, provides a powerful new strategy for human skin care in vivo, particularly for hyperpigmentation treatment and aging prevention. In this study, tyrosinase (Tyr, the rate-limiting enzyme of melanin (black pigment biosynthesis, was served as a target for treatment of hyperpigmentation in mouse and human skins. There are over 54 native microRNA capable of silencing human tyrosinase for skin whitening and lightening. To this, we have designed a mir-434-5p homologue and used it to successfully demonstrate the feasibility of miRNA-mediated skin whitening and lightening in vitro and in vivo. Under the same experimental condition in the trials, Pol-II-directed intronic mir-434-5p expression did not cause any detectable sign of cytotoxicity, whereas siRNAs targeting the same sequence often induced certain nonspecific mRNA degradation as previously reported. Because the intronic miRNA-mediated gene silencing pathway is tightly regulated by multiple intracellular surveillance systems, including Pol-II transcription, RNA splicing, exosomal digestion and nonsense-mediated RNA decay (NMD, the current findings underscore the fact that intronic miRNA agents, such as manually re-designed mir-434-5p homologues, are effective, target-specific and safe to be used for skin whitening without any detectable cytotoxic effect. Given that the human skins also express a variety of other native miRNAs, we may re-design these miRNAs based on their individual functions for skin care, which may provide significant insights into areas of opportunity for new cosmetic and/or therapeutical applications.Keywords: microRNA, miRNA, mir-434, intron, gene silencing, RNAi, tyrosinase, melanin, cosmetics, pigmentation, skin whitening

  2. Introduction to biomass energy project financing, funding sources and government strategies

    Biomass projects can help developing countries to protect their environment as well as to build a modem infrastructure. However, such projects present, in addition to the more typical risks associated with fossil-fuel projects, certain risks relating to the unique technologies and fuels used in such projects. Further, their location in developing countries regularly creates enhanced political and credit risk as well. Biomass power projects, like any other power project, must be financed. To be financeable, a power project should allocate risk in the most efficient way, so as to maximize return on investment. This paper examines the way in which various project documents can be structured to allocate most efficiently the technology and fuel risks unique to biomass projects, as well as the more typical risks, such as construction risk, permitting risk, expropriation risk, currency risk, country risk, sovereign risks, operating risks and credit risk. In addition, this paper summarizes the public financing sources and support that are available to assist in meeting the unique risk profiles of biomass projects. Specifically, it examines some of the principal multilateral and export credit agencies having involvement in this area. Finally, it examines potential strategies available to the developer of a biomass project for soliciting the involvement of, and negotiating with, local governments and public financing agencies. (author)

  3. MiRNA-199a-5p influences pulmonary artery hypertension via downregulating Smad3.

    Liu, Yuanhua; Liu, Guanghui; Zhang, Hui; Wang, Jing

    2016-05-13

    MicroRNAs (miRNAs) play important roles in pulmonary artery hypertension (PAH). Recently, it has been reported that miR-199a-5p participates in the progression of chronic obstructive pulmonary disease, ventricular hypertrophy and heart failure. However, the roles of miR-199a-5p in PAH are still unclear. In the present study, miR-199a-5p was investigated in PAH rat models and in human pulmonary artery smooth muscle cells (HPASMCs) and endothelial cells (HPAECs). The expression of miR-199a-5p was significantly increased following PAH induction, and anti-miR-199a-5p could increase the nitric oxide (NO) level and decrease the PAH-induced upregulation of pulmonary artery pressure and right ventricular hypertrophy. Moreover, in HPASMCs and HPAECs, miR-199a-5p overexpression could inhibit the level of NO and promote the concentration of Ca(2+), but anti-miR-199a-5p showed opposite results. Further analysis demonstrated that miR-199a-5p attenuated the expression of Smad3. Importantly, Smad3 was confirmed to be the target gene of miR-199a-5p using dual-luciferase reporter assay. Mechanism analyses revealed that the downregulation of NO and the upregulation of Ca(2+) caused by miR-199a-5p were all reversed by Smad3 overexpression in HPASMCs and HPAECs. Moreover, in PAH model, Smad3, p-Smad3 and Smad4 were all downregulated in lung tissues, and SIS3 (Smad3 inhibitor) could reverse the effects of anti-miR-199a-5p in PAH rats. Our date suggest that miR-199a-5p may function as a regulator of PAH by targeting Smad3, indicating a novel therapeutic strategy for patients with PAH. PMID:27038547

  4. Phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ), a lipid signalling enigma.

    Giudici, Maria-Luisa; Clarke, Jonathan H; Irvine, Robin F

    2016-05-01

    The phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are an important family of enzymes, whose physiological roles are being teased out by a variety of means. Phosphatidylinositol-5-phosphate 4-kinase γ (PI5P4Kγ) is especially intriguing as its in vitro activity is very low. Here we review what is known about this enzyme and discuss some recent advances towards an understanding of its physiology. Additionally, the effects of the ATP-competitive inhibitor I-OMe Tyrphostin AG-538 on all three mammalian PI5P4Ks was explored, including two PI5P4Kγ mutants with altered ATP- or PI5P-binding sites. The results suggest a strategy for targeting non-ATP binding sites on inositol lipid kinases. PMID:26710750

  5. The Government Subsidy Strategy Choice for Firm’s R&D: Input Subsidy or Product Subsidy?

    Zhiying Liu

    2014-01-01

    Full Text Available To encourage enterprises to conduct technology innovation, the government needs to formulate appropriate subsidies policy. This paper compares two R&D subsidy policies in a supplier-manufacturer supply chain, in which the manufacturer conducts R&D activity for quality improvement. By means of game theory, we investigate the optimal decisions of the players under the two R&D subsidy policies, that is, input subsidy policy and product subsidy policy. Finally, we compare the profits and welfare to explore the better R&D subsidy policy and provide decision support for government to formulate subsidy policy. The results show that under input subsidy policy the optimal production output, quality improvement, profits, government subsidies, and social welfare are all lower than those of product subsidy policy. Therefore, the government should use product subsidy strategy to encourage enterprise R&D activities.

  6. Sustainable Cost Transformation in Governments Using Accelerated Design of Shared Services, Social CRM and Information Strategy Development

    Prayas Kad

    2012-03-01

    Full Text Available In advance of the current economic downturn, governments around the world had embarked uponvery well intentioned efficiency remedial measures by observing its customers’ needs and expectations,implementing the shared design services catering to its various common functions across the departments, leveraging benefits with state-of-art introduction of Information technology and Social CRM. Bringing this approach together helps cost reduction programs introduced by the government produce better outcome and deliver efficiencies and effectiveness in various government functions along with endorsing sustainability in its different endeavors. Strong alignment among the various government departments and buy-in to the shared-services philosophy has been realized as the major contributing factor enabling the effective functioning and hence tools the SCRM and I.T. Strategy have been bundled together forming a collaborative approach.

  7. Cloud Computing Architecture: The Improved Strategy for Good E-Governance

    Dr. G. P. Singh Rajendra Singh Thapa

    2011-08-01

    Full Text Available Cloud Computing provides a great opportunity for governments across the globe, to provide reliable E-Governance quickly, at lower costs. Cloud computing features like application virtualization, end-to-end service management, instant deployment and ease of maintenance are catalysts that jumpstart application deployment on the Cloud. With proper planning, execution, training and good management, the Cloud infrastructure can greatly reduce overall costs for government departments maintaining and managing E-Services for E-Governance, and help in efficiently utilization.

  8. Teacher Professional Development Strategies in Australian Government and Professional Associations Documents

    Kostina Ludmyla

    2015-03-01

    Full Text Available Teacher in Australia is determined as an active participant of professional community with high level of collaboration, professional development coherent activities and collaborative learning practice. Thus, teacher quality is one of critical factors affecting student outcomes. The article touches upon the issue of the potential to improve secondary school teacher professional expertise in Australia. These are initiatives approved by Australian specific organizations at government and non-government levels. The author describes the goals and directions of secondary school teacher government support and government strong requirements for teacher professional learning. The article also considers the role of Australian professional education organizations in teacher professional growth. The analysis of the goals is carried out by means of government and professional education organizations documents. The author reports that social context of secondary school teacher professional development in Australia is provided through government education institutions. In support of this fact there is a range of government projects, programmes and documents approved at international and national levels and aimed to encourage lifelong quality teacher development. Furthermore, teacher professional development support is also organized by various Australian professional associations that work collaboratively. Moreover, these associations are not only focused on teacher professional development national standards, requirements and forms but global trends in professional learning and performance.

  9. The impact of the government policy on the Chinese electric gehicle industry and business strategy management : Case of FAW

    Li, Zhe; Lu, Sun

    2011-01-01

    Background: The electric vehicle industry is an emerging industry worldwide. In China the development of the electric vehicle industry is rapid. The government policy is of great influence on the economy in the Chinese context. The Chinese electric vehicle company has to design the right business strategy to maintain and enhance its competitive advantages in order to respond to challenges. Aim: This study analyzes the five competitive forces of the Chinese electric vehicle industry and the ef...

  10. The persistent food crisis in Ethiopis: causes, government responses and household strategies; the case of Enebse Sar Midir district

    Lakew, Ejiga Jemberu

    2006-01-01

    This study looks into the underlying causes of household food shortage and coping and survival strategies of households. It also analyzes government intervention undertaken to address the problem. It was based on a field survey in three peasant associations of the Enebse Sar Midir district in Amhara Region. The findings of this study show that various and interrelated factors are responsible for the problem of household food shortage. There are many natural predisposing factors such as drough...

  11. Image Repair Strategies of Rwandan Government in the Post-genocide Era: A Historical and Critical Analysis

    Olatunji, Ebenezer Oluwole

    2014-01-01

    ABSTRACT: This study employed Crisis-Communication theoretical framework to examine the responses of the government of Rwanda to the 1994 genocide which arguably posed the most serious challenge to the country’s image since independence from Belgium in 1962. It also evaluated the effectiveness of the image-restoration and repair strategies- using a model proposed by image restoration scholars, Benoit & Pang, (2008). The investigation and analysis were done using a combination of historica...

  12. Stuck in the tar sands : how the federal government's proposed climate change strategy lets oil companies off the hook

    The credibility of any federal climate change strategy must be measured against its ability to reduce emissions from the tar sands. However, the federal government has proposed a climate change strategy that would allow tar sands producers to double their total emissions over the next decade. This report discussed how the federal government's proposed climate change strategy lets oil companies off the hook. The report discussed the problems and harmful effects associated with tar sands development, including greenhouse gas emissions; water depletion and pollution; toxic air emissions; destruction of the boreal forest; violation of native rights; threat to energy security; and negative socio-economic spin-off from an overheated economy. The federal government's proposed strategy was also assessed in terms of its weak greenhouse gas targets; ignoring the recent growth in tar sands emissions; adopting intensity-based targets instead of hard caps on greenhouse gas pollution, allowing total emissions from the tar sands to keep climbing; putting off critical measures until 2018; awarding oil companies hundreds of millions of dollars in credits for meeting targets they have already adopted voluntarily; lowballing the price of oil and downplaying future growth in tar sands emissions; ignoring huge portions of the oil industry's greenhouse gas pollution; letting oil companies buy their way out at rockbottom prices instead of forcing them to reduce their own emissions; and subsidizing increased tar sands production. It was concluded that the federal government's proposed plan to reduce greenhouse gas emissions was inadequate, because it failed to crack down on rising greenhouse gas emissions from the tar sands, one of Canada's most carbon intensive and fastest growing industries. 29 refs., 1 appendix

  13. Building a Governance Strategy for CER: The Patient Outcomes Research to Advance Learning (PORTAL) Network Experience

    Paolino, Andrea R.; McGlynn, Elizabeth A.; Lieu, Tracy; Nelson, Andrew F.; Prausnitz, Stephanie; Horberg, Michael A.; Arterburn, David E.; Gould, Michael K.; Laws, Reesa L.; Steiner, John F.

    2016-01-01

    Introduction: The Patient Outcomes Research to Advance Learning (PORTAL) Network was established with funding from the Patient-Centered Outcomes Research Institute (PCORI) in 2014. The PORTAL team adapted governance structures and processes from past research network collaborations. We will review and outline the structures and processes of the PORTAL governance approach and describe how proactively focusing on priority areas helped us to facilitate an ambitious research agenda. Background: For years a variety of funders have supported large-scale infrastructure grants to promote the use of clinical datasets to answer important comparative effectiveness research (CER) questions. These awards have provided the impetus for health care systems to join forces in creating clinical data research networks. Often, these scientific networks do not develop governance processes proactively or systematically, and address issues only as problems arise. Even if network leaders and collaborators foresee the need to develop governance approaches, they may underestimate the time and effort required to develop sound processes. The resulting delays can impede research progress. Innovation: Because the PORTAL sites had built trust and a foundation of collaboration by participating with one another in past research networks, essential elements of effective governance such as guiding principles, decision making processes, project governance, data governance, and stakeholders in governance were familiar to PORTAL investigators. This trust and familiarity enabled the network to rapidly prioritize areas that required sound governance approaches: responding to new research opportunities, creating a culture of trust and collaboration, conducting individual studies, within the broader network, assigning responsibility and credit to scientific investigators, sharing data while protecting privacy/security, and allocating resources. The PORTAL Governance Document, complete with a Toolkit of

  14. Connected Government: An Exploration of the UAE's Identity Management Integration Strategy

    Ali M. Al-Khouri

    2013-01-01

    The subject of connected government is coming once again to the forefront of national development priorities around the world. This stems from the need to address various local and global necessities in light of the changing landscape of the new digital world we live in today. In a connected government context, public service agencies are needed to act as a single enterprise so that citizens feel they are being served by one organization rather than a number of different public authorities. I...

  15. Governance approaches in European territorial cooperation programmes and the implications of macro-regional strategies.

    van der Zwet, Arno; Mcmaster, Irene; BACHTLER, John

    2012-01-01

    Historically, cooperation across borders was an area of activity dominated by central government actors. However, in the EU some of the earliest institutionalised forms of territorial cooperation are based on bottom-up initiatives involving border municipalities. Current territorial cooperation arrangements continue to be strongly based upon local and regional institutions and actors. Theoretical work on Europeanisation, multi-level governance and new regionalism highlights the increased role...

  16. Industrial Deregulation Policy of New Government and Improvement Strategy of Nuclear Safety Regulation

    New Government launched in Feb. 2008 pledged the 'economic revival through alleviating the enterprise regulation.' Based on this commitment, the government established a strategic goal, that is, 'zero-base regulation innovation' and now is performing nine governmental projects. Although the industrial safety deregulations including the nuclear safety deregulation are not comprised in the projects, 43 regulation issues, among 267 issues suggested by 5 economic and industrial organizations at the beginning of this year, correspond to the industry safety. Therefore, the demand for reform of the safety regulation is unavoidable. Accordingly, we will investigate the direction to cope with the need for the nuclear safety deregulation in this paper

  17. Governance Strengths and Weaknesses to implement the Marine Strategy Framework Directive in European Waters

    Freire-Gibb, L. Carlos; Koss, Rebecca; Piotr, Margonski;

    2014-01-01

    addresses the Strengths, Weakness, Opportunities and Threats (SWOT) of the current European marine governance structures and its relationship to implement the MSFD. Results of the SWOT analysis were acquired through a combination of approaches with MSFD experts and stakeholders including: 30 face......-to-face interviews, an online survey with 264 stakeholder respondents and focus groups within each European marine region. The SWOT analysis concurrently identifies common strengths and weakness and key governance issues for implementing the MSFD for European marine regions. This paper forms one assessment within...

  18. Poverty in Mexico : An Assessment of Conditions, Trends and Government Strategy

    Walton, Michael; Lopez-Acevedo, Gladys

    2005-01-01

    In 2002, half of Mexico's population lived in poverty and one fifth in extreme poverty, slightly lower than before the 1994-1995 crisis. Mexico has made major progress in some poverty dimensions -health, nutrition and education outcomes, access to basic health and education services, electricity, water and (to a lesser extent) sanitation. Large increases in government spending enabled key ...

  19. Social capital, survival strategies, and their potential for post-conflict governance in Liberia

    Sawyer, Amos

    2005-01-01

    This paper investigates how people created, adapted and used social capital and conflict resolution during more than a decade of violent conflict in Liberia, and the potential of such capital to contribute to post-conflict peacebuilding and self-governance. – institutions ; conflict ; community ; society ; reconstruction

  20. Empowerment and performance in local government : the impact of empowerment strategies on service improvement

    Tickner, Leslie

    2010-01-01

    This study examines the impact an empowerment strategy may have when applied to public sector employees delivering Environmental Services. The study employs a case study method as its central research strategy with ten sample local authorities chosen as strategic informants. The key issues considered were the relevance of the appropriate structure within the organisation, the importance of employee engagement, the impact of the management or leadership style, and the opportunity for implement...

  1. Developing knowledge and strategies for enabling and governing transitions to a low carbon society

    Jørgensen, Michael Søgaard; Jørgensen, Ulrik; Lauridsen, Erik Hagelskjær

    organizations. Transition of the path-dependent, socio-technical regimes in the energy system is a governance challenge, since transitions need to occur simultaneously in different arenas without necessarily having a specific „centre‟ of co-ordination. Changes of regimes require innovative breakthroughs in......, companies, cities, and national and international policy. Theoretically the research alliance builds upon a combination of theories including social practice theory, innovation economy, institutional theory, actor-network theory and governance theory. Through a combination of historical analysis, case...... stakeholders to make continuous adjustments of objectives and means in unavoidably conflict ridden transition processes.  Analyses of how key measures and institutions at different societal levels might contribute to transition processes.  Characterisation of 4-6 typical sustainable transition set-ups as...

  2. Hedging Alberta Government's Oil and Gas Revenue: Is Acting Like a Farmer a Viable Strategy?

    Hotz, Joffre; Unterschultz, James R.

    2009-01-01

    The provincial government of Alberta in Canada experiences significant annual revenue variability arising from changes in crude oil and natural gas prices. This research evaluated whether Alberta’s non-renewable revenue risk could be managed using a derivatives hedging program. Results from a historical hedging simulation approach suggested that such a program would not have been the most effective method of managing revenue risk over the period of 1995-96 to 2003-04. Total impacts of hedging...

  3. Teacher Professional Development Strategies in Australian Government and Professional Associations Documents

    Kostina Ludmyla

    2015-01-01

    Teacher in Australia is determined as an active participant of professional community with high level of collaboration, professional development coherent activities and collaborative learning practice. Thus, teacher quality is one of critical factors affecting student outcomes. The article touches upon the issue of the potential to improve secondary school teacher professional expertise in Australia. These are initiatives approved by Australian specific organizations at government and non-gov...

  4. Developing knowledge and strategies for enabling and governing transitions to a low carbon society

    Jørgensen, Michael Søgaard; Jørgensen, Ulrik; Lauridsen, Erik Hagelskjær

    2011-01-01

    Most of the research on low carbon society in Denmark has hitherto focused on developing scenarios and analyzing possible policy instruments, including market mechanisms, costs and impacts in relation to known options and impacts. The Danish Council of Strategic Research funds the four year research alliance “Enabling and governing transitions to a low carbon society” during 2010-2013. The aim of this alliance is to conceptualize the dynamics of transition processes towards a low carbon socie...

  5. International R&D rivalry and industrial strategy without government commitment

    Leahy, Dermot; Neary, J. Peter

    1995-01-01

    We examine optimal industrial and trade policies in a series of dynamic oligopoly games in which a home and a foreign firm compete in R&D and output. Alternative assumptions about the timing of moves and the ability of agents to commit intertemporally are considered. We show that the home export subsidy, R&D subsidy and welfare are higher when government commitment is credible than in the dynamically consistent equilibrium without commitment. Commitment thus yields welfare gains (though they ...

  6. Justifying accounting change through global discourses and legitimation strategies. The case of the UK central government.

    Hyndman, Noel; Liguori, Mariannunziata

    2016-01-01

    Accounting has been viewed, especially through the lens of the recent managerial reforms, as a neutral technology that, in the hands of rational managers, can support effective and efficient decision making. However, the introduction of new accounting practices can be framed in a variety of ways, from value-neutral procedures to ideologically-charged instruments. Focusing on financial accounting, budgeting and performance management changes in the UK central government, and through extensive ...

  7. Issues and Strategies in Promoting Democracy and Good Governance: Nigerian and Malaysian Examples

    Abdulkadir M.S

    2011-12-01

    Full Text Available This paper examines both the political structures and institutions of Nigeria and Malaysia with a view of highlighting areas of similarities and differences in their modus operandi. While Malaysia has witnessed a tremendous boost and radicalism after 20 years of Prime Minister Tun Dr. Mahathir Mohamad's rule, Nigeria since the restoration of democracy in 1999, after a long military rule, did not yield a proper institutionalization of democratic principles. There have been cries against anti- and undemocratic practices of the eleven years old civilian government in Nigeria. The two countries under review operate a Federal Constitution, promote the principles of rule of law, protect the rights and liberties of the citizens but differ in the system of government. Malaysia operates parliamentary system while Nigeria is built on a presidential system. What went wrong and how can democracy be promoted and consolidated? The paper explores answers to the above question. The conclusion of this article is drawn on the premise of providing plausible suggestions that will promote democracy and good governance in the two countries.

  8. Spam SMS Classification Governance Strategies%垃圾短信分类治理对策研究

    曾剑秋; 杨光永; 董豪

    2015-01-01

    Taking spam SMS governance as the entry point and based on the theory of supply and demand analy-sis, a two-dimensional asymmetric evaluation matrix and hierarchical classification governance strategies are presented from two dimensions of SMS content and its transmission channel.Through the analysis, it is found that the current governance emphasis is the spam SMS related with the port, of which the advertising spam mes-sage accounts for the largest proportion, while the illegal SMS spam, such as fraud and pornography spam, harms the society most, and relevant recommendations of spam SMS classification governance is put forward. Spam SMS governance is researched from a new perspective, and the results will provide references both to the regulatory authorities and to telecom operators, and promote the healthy development of SMS.%以垃圾短信治理问题为切入点, 以供需分析为理论基础, 从短信内容与短信发送渠道两个维度分别提出非对称二维评判矩阵和分层分级治理策略. 通过分析发现, 目前治理重点转向 "端口" 类垃圾短信, 广告类垃圾短信数量占比最大, 而诈骗、 色情等违法类短信社会危害最大, 因而提出垃圾短信分类治理的相关建议. 从新的视角研究垃圾短信治理问题, 给监管部门及电信运营企业提供理论及方法借鉴, 并促进短信业务的健康发展.

  9. The moderating role of competitive strategy in relating frim performance to quality management and government support

    Han, J.; Omta, S.W.F.; Trienekens, J.H.; Kemp, R.G.M.

    2010-01-01

    One of the main concerns in companies is quality management and its relationship to firm performance. Recently a growing interest in research is the important role of the business environment in the competitive strategy choices of companies. By proposing a conceptual framework for a general model th

  10. miR290-5p/292-5p activate the immunoglobulin kappa locus in B cell development.

    Patty B Garcia

    Full Text Available Regulated expression of miRNAs influences development in a wide variety of contexts. We report here that miR290-5p (100049710 and miR292-5p (100049711 are induced at the pre-B stage of murine B cell development and that they influence assembly of the Igκ light chain gene (243469 by contributing to the activation of germline Igκ transcription (κGT. We found that upon forced over-expression of miR290-5p/292-5p in Abelson Murine Leukemia Virus (AMuLV transformed pro-B cells, two known activators of κGT, E2A (21423 and NF-κB (19697, show increased chromosomal binding to the kappa intronic enhancer. Conversely, knockdown of miR290-5p/292-5p in AMuLV pro-B cells blunts drug-induced activation of κGT. Furthermore, miR290-5p/292-5p knockdown also diminishes κGT activation, but not Rag1/2 (19373, 19374 expression, in an IL-7 dependent primary pro-B cell culture system. In addition, we identified a deficiency in κGT induction in miR290 cluster knockout mice. We hypothesize that increased expression of miR290-5p and miR292-5p contributes to the induction of κGT at the pre-B stage of B cell development through increased binding of NF-κB and E2A to kappa locus regulatory sequences.

  11. miR290-5p/292-5p activate the immunoglobulin kappa locus in B cell development.

    Garcia, Patty B; Cai, Amie; Bates, Jamie G; Nolla, Hector; Schlissel, Mark S

    2012-01-01

    Regulated expression of miRNAs influences development in a wide variety of contexts. We report here that miR290-5p (100049710) and miR292-5p (100049711) are induced at the pre-B stage of murine B cell development and that they influence assembly of the Igκ light chain gene (243469) by contributing to the activation of germline Igκ transcription (κGT). We found that upon forced over-expression of miR290-5p/292-5p in Abelson Murine Leukemia Virus (AMuLV) transformed pro-B cells, two known activators of κGT, E2A (21423) and NF-κB (19697), show increased chromosomal binding to the kappa intronic enhancer. Conversely, knockdown of miR290-5p/292-5p in AMuLV pro-B cells blunts drug-induced activation of κGT. Furthermore, miR290-5p/292-5p knockdown also diminishes κGT activation, but not Rag1/2 (19373, 19374) expression, in an IL-7 dependent primary pro-B cell culture system. In addition, we identified a deficiency in κGT induction in miR290 cluster knockout mice. We hypothesize that increased expression of miR290-5p and miR292-5p contributes to the induction of κGT at the pre-B stage of B cell development through increased binding of NF-κB and E2A to kappa locus regulatory sequences. PMID:22928038

  12. The missing link between technological standards and value-chain governance: the case of patent-distribution strategies in the mobile-communication industry

    Hu Wen; Daniel You-Ren Yang

    2010-01-01

    In this paper we explore the effects of technological standards on the governance structure of production networks by investigating patent-distribution strategies in the global mobile-communication industry. Through a comparative analysis of two mobile-communication technology standards—GSM and CDMA—we find that there exist significantly different patent-distribution strategies which result in varied governance structure as well as power relations within seemingly similar production networks....

  13. Civic engagement and local government strategies for sustainable local community development

    Larsen, Jacob Norvig

    Across Europe more and more citizens involve in voluntary grassroots and NGO activity. Concurrently, more local and national governments express an interest in increasing collaboration with voluntary organisations. The curiosity and interest as regards voluntary labour from public bodies seems to...... regeneration with a range of participatory and collaborative measures aimed at involving local citizens in urban projects and programmes. In the paper it is discussed what motivates and drives members of voluntary community organisations (VCOs). Moreover it is discussed what is the role of volunteering in...

  14. Examining Why the Canadian Federal Government Placed an Orphan Drug Strategy on Their Decision Agenda Now

    Mark Gary Embrett

    2014-02-01

    Full Text Available The Ministry of Health’s announcement of a National Orphan Drug Framework on 3 October 2012 was the first federal public acknowledgement of orphan drugs since the 1997 Drugs Directorate (DD policy statement. The reform primarily announced an Orphan Drug Policy for Canada. This paper explains why the government decided to make this announcement now. Media and Parliamentary documents were analyzed for their use of symbols, numbers, and language in causal stories told by political actors. The initial story was that Canada’s population was too small and the cost too high for an orphan drug policy. Over the next fifteen years, a powerful interest group, the Canadian Organization for Rare Disorders (CORD, mobilized the rare disease community into a cooperative effort that generated collective action. They redefined the DD story from one of natural causes, to inadvertence, and finally to intentional causation. Their story invoked a federal response because it blamed the government directly for not acting on behalf of the 3 million Canadians with rare diseases, when patients in other countries were receiving better care.

  15. Potentials and constraints of modeling for transdisciplinary co-producing strategies for sustainable water governance

    Schneider, Flurina

    2013-01-01

    Both climate change and socio-economic development will significantly modify the supply and consumption of water in future. Consequently, regional development has to face aggravation of existing or emergence of new conflicts of interest. In this context, transdisciplinary co-production of knowledge is considered as an important means for coping with these challenges. Accordingly, the MontanAqua project aims at developing strategies for more sustainable water management in the study area Cr...

  16. Assessment of governance strategies for climate adaptation in Flanders/Belgium

    Verhofstede, Björn; Leinfelder, Hans; Allaert, Georges

    2010-01-01

    Climate discourse in recent decades has mainly focused on the issue of mitigation. Through a better understanding and assessment of climate challenges, adaptation arises as a complementary strategy to mitigation. Vulnerability in relation to climate change is seen as a function of exposure, sensitivity and adaptive capacity. Adaptation can influence sensitivity while mitigating impacts on the exposure to climate change. (IPCC, 2007). Adaptation requires space for climate on a local scale and ...

  17. Open Innovation: Implications for Corporate Strategies, Government Policy and International R&D Spillovers

    Jean Guinet; Dirk Meissner

    2012-01-01

    The paper analyzes the contribution of public policy to the open innovation process. Innovation processes are dynamic and global. Actors must adapt their strategies to new contexts, including the increasingly knowledge-based global competition. They must reconcile the need for speed in commercial exploitation of new products in order to ensure continuous investments with long lead-time in the development of radical innovation capabilities. For the world leaders in their industries, suppliers ...

  18. Governing Migration: Immigrant Groups' Strategies in Three Italian Cities - Rome, Naples and Bari

    Crane, Kristine

    2004-01-01

    Ethnic networks constitute an important component of immigrants' integration in their host societies. This has been a particularly important strategy in Italy, where institutional assistance for immigrants is often paltry and problematic. This paper examines three ethnic communities in Italy that have been particularly successful in using their ethnic social capital for integrating into Italian society at the city level: the Mauritians in Bari, Filipinos in Rome and Chinese in Naples. Sending...

  19. Developing conservation governance strategies: holistic management of protected areas in Nepal

    Budhathoki, Prabhu

    2012-01-01

    The Buffer Zone (BZ) concept has been introduced in Nepal as a key component of the national biodiversity conservation strategy to mitigate the impacts of protected areas on local communities, and thereby reduce adverse impacts of local people on protected areas. Unlike traditional Buffer Zone programmes which are mostly limited to creating a protective layer and/or distributing economic benefits to local people, the Buffer Zone management approach in Nepal integrates livelihoods and conserva...

  20. A Blueprint for Florida's Clean Energy Future - Case Study of a Regional Government's Environmental Strategy

    Margaret Lowman

    2009-04-01

    Full Text Available On 13 July 2007, Governor Charlie Crist of Florida signed executive orders to establish greenhouse gas emission targets that required an 80 percent reduction below 1990 levels by the year 2050. Florida is a very high-risk state with regard to climate change. Its 1,350-mile-long coastline, location in "Hurricane Alley," reliance on coral reefs and other vulnerable natural resources for its economy, and the predictions that state population could double in the next 30 years all contribute to this designation of "high-risk. As a consequence of the potential economic and ecological impacts of climate change to Florida, a series of Action Teams were created to plan for adaptation to impending environmental changes. As the 26th largest emitter of carbon dioxide on a global scale, Florida needs to act aggressively to create a clean energy footprint as part of its statewide initiatives but with global impacts. This case study examines the process and expected outcomes undertaken by a regional government that anticipates the need for stringent adaptation.

  1. Anti-corruption strategies in some South-Eastern European states.An empirical study on the impact of the government performance

    Matei, Ani; Lucica MATEI

    2010-01-01

    The preoccupations about conceiving and promoting efficient anti-corruption strategies exist in most states, especially in the developing countries. The opportunity of such strategies derives from the direct link, demonstrated theoretically and empirically, between the effects of the anti-corruption strategies and government performance, translated both in the economic and social results and living standard, welfare etc. In the last decades, the transnational actors – UN, World Bank, OECD, EU...

  2. An Analysis of the Collusive Game and Governance Strategy between the Supervisor and the Contractor under the Asymmetric Information

    TaoYan

    2013-01-01

    Full Text Available Project contract is the incomplete contract and the rights and obligations between the parties of the contract cannot be accurately determined because of the inherent characteristics of asymmetric information, incompleteness, the parties' bounded rationality and each party in pursuit of maximizing their own interests. This gives rise to the collusive risk of the project in the process of construction between the supervisor and the contractor. This study firstly takes the supervisor and contractor as each party of the game by using the view of game theory and establishes the game model based on the theory of asymmetric information and then analyzes the effective treatment for both parties' gambling behaviors, finally discuss the governance strategy on the prevention of the collusion between the supervisor and constructor.

  3. Evidence for xylitol 5-P production in human dental plaque

    The Turku sugar studies indicated that xylitol may possess a caries-therapeutic effect. More recent data show that xylotol exhibits a bacteriostatic activity on a wide range of bacteria based on uptake and expulsion of xylitol. Intracellular xylitol 5-P appears to be a key substance associated with inhibition of bacterial metabolism by xylitol. This has been shown in studies with pure strains of bacteria, mainly Streptococcus mutans. The aim of the present study was to examine if production of xylitol 5-P occurs in freshly collected dental plaque which is exposed to labeled xylitol. Plaque extracts were analyzed by thin-layer chromatography combined with autoradiography and high performance liquid chromatography. Strong indications were obtained that xylitol 5-P is readily produced by dental plaque. No other significant xylitol metabolites were identified. The bacteriostatic properties of xylitol in plaque are a mechanism which may well account for the caries-therapeutic effect of xylitol. (au)

  4. Evidence for xylitol 5-P production in human dental plaque

    Waaler, S.M. (Department of Preclinical Techniques and Material Sciences and Department of Pedodontics, Dental Faculty, University of Oslo, Oslo (Norway))

    1992-01-01

    The Turku sugar studies indicated that xylitol may possess a caries-therapeutic effect. More recent data show that xylotol exhibits a bacteriostatic activity on a wide range of bacteria based on uptake and expulsion of xylitol. Intracellular xylitol 5-P appears to be a key substance associated with inhibition of bacterial metabolism by xylitol. This has been shown in studies with pure strains of bacteria, mainly Streptococcus mutans. The aim of the present study was to examine if production of xylitol 5-P occurs in freshly collected dental plaque which is exposed to labeled xylitol. Plaque extracts were analyzed by thin-layer chromatography combined with autoradiography and high performance liquid chromatography. Strong indications were obtained that xylitol 5-P is readily produced by dental plaque. No other significant xylitol metabolites were identified. The bacteriostatic properties of xylitol in plaque are a mechanism which may well account for the caries-therapeutic effect of xylitol. (au).

  5. 开放政府与政府数据公开战略%Open Government and Government Data Disclosure Strategy

    周和

    2012-01-01

    提高政府公信力是全球关注的问题,创新政府管理,建设透明与开放政府,更多地在公共事务上实行公民参与,已成为全球的发展趋势。各国政府也在努力寻找各种途径,使政府更加透明、回应性更强、更加负责和有效。这也使得美国“开放政府”行动的影响越来越大。透明度、参与和协作这三项原则,构成开放政府的基石。而合理地开放政府信息、扩大信息公开与敏感信息的保护、提高政府信息的可及性则是有效实施政府数据公开战略,建设开放政府的必然选择。%This paper describes the origin of open government, and discusses the connotation, value and trends of open government, and points out that innovative government management, building transparent and open government has become the development trend of the world. At the same time, this paper analyzes discussion of the Chinese scholars on building open government in China, and conducts specific discussion from three aspects: reali- zing greater disclosure of government data, finding a balance between open government and sensitive information protection, as well as facilitating public access to government information.

  6. D1-D5-P microstates at the cap

    Giusto, Stefano; Mathur, Samir D; Turton, David

    2012-01-01

    The geometries describing D1-D5-P bound states in string theory have three regions: flat asymptotics, an anti-de Sitter throat, and a 'cap' region at the bottom of the throat. We identify the CFT description of a known class of supersymmetric D1-D5-P microstate geometries which describe degrees of freedom in the cap region. The class includes both regular solutions and solutions with conical defects, and generalizes configurations with known CFT descriptions: a parameter related to spectral flow in the CFT is generalized from integer to fractional values. We provide strong evidence for this identification by comparing the massless scalar excitation spectrum between gravity and CFT and finding exact agreement.

  7. Energy and climate policy outlines for the near future - national strategy for implementation of the kyoto protocol. The government's report to parliament on 24 November 2005

    The energy and climate policy carried out in recent years has been based on the National Climate Strategy approved by the Government in 2001 and submitted to the Finnish Parliament as a government report. After completion of the strategy, however, the operating environment of the energy and climate policy has undergone so many changes that, in summer 2003, a stand was recorded in the programme of Prime Minister Matti Vanhanen's Government stating that the Government will implement and revise the National Climate Strategy taking into account the EU Directive on emissions trading and the Kyoto mechanisms. The revised strategy, presented in the document Energy and climate policy outlines for the near future - national strategy for implementation of the Kyoto Protocol, is given to Parliament as a government report. The report was prepared under the supervision of the Ministerial Working Group on Climate and Energy Policy. The practical preparatory work was carried out by the Climate and Energy Policy Network, comprised of representatives of the Ministry of Trade and Industry, the Ministry of Transport and Communications, the Ministry of Agriculture and Forestry, the Ministry for Foreign Affairs, the Ministry of Finance, and the Ministry of the Environment. The report consists of outline and strategy texts, including background information and stands taken, and four appendices. The strategy proper describes the changes that have taken place in the international operating environment, and presents the Government's outlines for the energy and climate policy in the coming years as well as the actions required by these outlines. The national emission target set for Finland for the Kyoto commitment period can be met with the actions specified in the strategy. According to the trend outlined in the strategy, the diversity of our energy system and the security of energy supply will be preserved, or even improved. The volume of indigenous energy sources, and their share of

  8. Energy and climate policy outlines for the near future. National strategy for implementation of the Kyoto Protocol. The government's report to parliament on 24 November 2005

    The energy and climate policy carried out in recent years has been based on the National Climate Strategy approved by the Government in 2001 and submitted to the Finnish Parliament as a government report. After completion of the strategy, however, the operating environment of the energy and climate policy has undergone so many changes that, in summer 2003, a stand was recorded in the programme of Prime Minister Matti Vanhanen's Government stating that the Government will implement and revise the National Climate Strategy taking into account the EU Directive on emissions trading and the Kyoto mechanisms. The revised strategy, presented in the document 'Energy and climate policy outlines for the near future - national strategy for implementation of the Kyoto Protocol', is given to Parliament as a government report. The report was prepared under the supervision of the Ministerial Working Group on Climate and Energy Policy. The practical preparatory work was carried out by the Climate and Energy Policy Network, comprised of representatives of the Ministry of Trade and Industry, the Ministry of Transport and Communications, the Ministry of Agriculture and Forestry, the Ministry for Foreign Affairs, the Ministry of Finance, and the Ministry of the Environment. The report consists of outline and strategy texts, including background information and stands taken, and four appendices. The strategy proper describes the changes that have taken place in the international operating environment, and presents the Government's outlines for the energy and climate policy in the coming years as well as the actions required by these outlines. The national emission target set for Finland for the Kyoto commitment period can be met with the actions specified in the strategy. According to the trend outlined in the strategy, the diversity of our energy system and the security of energy supply will be preserved, or even improved. The volume of indigenous energy sources, and their share of

  9. Outline of the Energy and Climate Policy for the Near Future - National Strategy to Implement the Kyoto Protocol. Government Report to Parliament 24 November 2005

    The energy and climate policy carried out in recent years has been based on the National Climate Strategy approved by the Government in 2001 and submitted to the Finnish Parliament as a government report. After completion of the strategy, however, the operating environment of the energy and climate policy has undergone so many changes that, in summer 2003, a stand was recorded in the programme of Prime Minister Matti Vanhanen's Government stating that the Government will implement and revise the National Climate Strategy taking into account the EU Directive on emissions trading and the Kyoto mechanisms. The revised strategy, presented in the document Energy and climate policy outlines for the near future - national strategy for implementation of the Kyoto Protocol, is given to Parliament as a government report. The report was prepared under the supervision of the Ministerial Working Group on Climate and Energy Policy. The practical preparatory work was carried out by the Climate and Energy Policy Network, comprised of representatives of the Ministry of Trade and Industry, the Ministry of Transport and Communications, the Ministry of Agriculture and Forestry, the Ministry for Foreign Affairs, the Ministry of Finance, and the Ministry of the Environment. The report consists of outline and strategy texts, including background information and stands taken, and four appendices. The strategy proper describes the changes that have taken place in the international operating environment, and presents the Government's outlines for the energy and climate policy in the coming years as well as the actions required by these outlines. The national emission target set for Finland for the Kyoto commitment period can be met with the actions specified in the strategy. According to the trend outlined in the strategy, the diversity of our energy system and the security of energy supply will be preserved, or even improved. The volume of indigenous energy sources, and their share of

  10. Energy Efficiency Programs in K-12 Schools: A Guide to Developing and Implementing Greenhouse Gas Reduction Programs. Local Government Climate and Energy Strategy Series

    US Environmental Protection Agency, 2011

    2011-01-01

    Saving energy through energy efficiency improvements can cost less than generating, transmitting, and distributing energy from power plants, and provides multiple economic and environmental benefits. Local governments can promote energy efficiency in their jurisdictions by developing and implementing strategies that improve the efficiency of…

  11. PI5P Triggers ICAM-1 Degradation in Shigella Infected Cells, Thus Dampening Immune Cell Recruitment.

    Boal, Frédéric; Puhar, Andrea; Xuereb, Jean-Marie; Kunduzova, Oksana; Sansonetti, Philippe J; Payrastre, Bernard; Tronchère, Hélène

    2016-02-01

    Shigella flexneri, the pathogen responsible for bacillary dysentery, has evolved multiple strategies to control the inflammatory response. Here, we show that Shigella subverts the subcellular trafficking of the intercellular adhesion molecule-1 (ICAM-1), a key molecule in immune cell recruitment, in a mechanism dependent on the injected bacterial enzyme IpgD and its product, the lipid mediator PI5P. Overexpression of IpgD, but not a phosphatase dead mutant, induced the internalization and the degradation of ICAM-1 in intestinal epithelial cells. Remarkably, addition of permeant PI5P reproduced IpgD effects and led to the inhibition of neutrophil recruitment. Finally, these results were confirmed in an in vivo model of Shigella infection where IpgD-dependent ICAM-1 internalization reduced neutrophil adhesion. In conclusion, we describe here an immune evasion mechanism used by the pathogen Shigella to divert the host cell trafficking machinery in order to reduce immune cell recruitment. PMID:26776508

  12. PI5P Triggers ICAM-1 Degradation in Shigella Infected Cells, Thus Dampening Immune Cell Recruitment

    Frédéric Boal

    2016-02-01

    Full Text Available Shigella flexneri, the pathogen responsible for bacillary dysentery, has evolved multiple strategies to control the inflammatory response. Here, we show that Shigella subverts the subcellular trafficking of the intercellular adhesion molecule-1 (ICAM-1, a key molecule in immune cell recruitment, in a mechanism dependent on the injected bacterial enzyme IpgD and its product, the lipid mediator PI5P. Overexpression of IpgD, but not a phosphatase dead mutant, induced the internalization and the degradation of ICAM-1 in intestinal epithelial cells. Remarkably, addition of permeant PI5P reproduced IpgD effects and led to the inhibition of neutrophil recruitment. Finally, these results were confirmed in an in vivo model of Shigella infection where IpgD-dependent ICAM-1 internalization reduced neutrophil adhesion. In conclusion, we describe here an immune evasion mechanism used by the pathogen Shigella to divert the host cell trafficking machinery in order to reduce immune cell recruitment.

  13. THEORETIC INCURSION IN THE IDENTIFICATION OF DETERMINANTS AND E-GOVERNMENT STRATEGY. EMPIRIC STUDY OVER THE GRADE OF IMPLEMENTATION OF E-GOVERNMENT IN BIHOR COUNTY

    Pop Cohut Ioana

    2012-01-01

    We are currently witnessing an unprecedented development of new technologies, that offers great opportunities for the modernization of the society, it changes radically the way governments, businesses and citizens have the opportunity to obtain goods and services, the way in which public services are provided that become increasingly important for citizens, the way of obtaining and transmitting information, the way in which business connections are done, the interaction between different comm...

  14. Inhibition of microRNA-31-5p protects human colonic epithelial cells against ionizing radiation

    Kim, Sang Bum; Zhang, Lu; Barron, Summer; Shay, Jerry W.

    2014-04-01

    MicroRNAs (miRNAs), endogenous non-coding small RNAs, are sensitive to environmental changes, and their differential expression is important for adaptation to the environment. However, application of miRNAs as a clinical prognostic or diagnostic tool remains unproven. In this study we demonstrate a chronic/persistent change of miRNAs from the plasma of a colorectal cancer susceptible mouse model (CPC;Apc) about 250 days after exposure to a simulated solar particle event (SPE). Differentially expressed miRNAs were identified compared to unirradiated control mice, including miR-31-5p, which we investigated further. To address the cellular function of miR-31-5p, we transfected a miR-31-5p mimic (sense) or inhibitor (antisense) into immortalized human colonic epithelial cells followed by gamma-irradiation. A miR-31-5p mimic sensitized but a miR-31-5p inhibitor protected colonic epithelial cells against radiation induced killing. We found that the miR-31-5p mimic inhibited the induction of hMLH1 expression after irradiation, whereas the miR-31-5p inhibitor increased the basal level of hMLH1 expression. The miR-31-5p inhibitor failed to modulate radiosensitivity in an hMLH1-deficient HCT116 colon cancer cell line but protected HCT116 3-6 and DLD-1 (both hMLH1-positive) colon cancer cell lines. Our findings demonstrate that miR-31-5p has an important role in radiation responses through regulation of hMLH1 expression. Targeting this pathway could be a promising therapeutic strategy for future personalized anti-cancer radiotherapy.

  15. Review of Ireland’s Road Safety Strategy. On behalf of Department of the Environment and Local Government, Ireland.

    Wegman, F.C.M.

    2003-01-01

    SWOV has been requested to carry out a review of Ireland's Road Safety Strategy. This review should pay attention to three aspects: (1) review developments and progress made under the current National Road Safety Strategy 1998-2002; (2) place Ireland's performance in an appropriate international context; and (3) suggest options for priorities for the next Strategy to cover period 2003-2007, paying regard to recent developments (including relevant international developments). The target of the...

  16. GOVERNANCE AND STRATEGY IMPLEMENTATION IN LOCAL CLUSTERS TO IMPROVE THE PERFORMANCEhttp://dx.doi.org/10.5585/riae.v9i2.1672

    Helen Fischer Günther

    2010-11-01

    Full Text Available Micro, small and medium enterprises (MSME are designed to operate in networks, cooperatively, in order to obtain benefits that would not occur through the alone action, and encourage the development of local productive arrangements (LPA. Emerge the need for synergy between the actors, operationalized by the mechanisms of integration, which must be managed for efficiency. These characteristics of cooperation and interaction impact the achievement of the objectives and strategies, and administrative functions and plans. Therein appear one of the challenges of present time: how to implement the strategies, plans, and how to make the strategy works? Governance emerges, then, as a medium to achieve the objectives and, so, talk about it in the LPA extends the focus on developing management methods to maintain the idiosyncrasies, to the same extent as they contribute to the effectiveness and improvement in performance.

  17. 76 FR 34650 - Models for a Governance Structure for the National Strategy for Trusted Identities in Cyberspace

    2011-06-14

    ... for the National Strategy for Trusted Identities in Cyberspace AGENCY: U.S. Department of Commerce... Ecosystem Framework in accordance with the National Strategy for Trusted Identities in Cyberspace (NSTIC or... importance of cyberspace to U.S. innovation, prosperity, education and political and cultural life, and...

  18. Review of Ireland’s Road Safety Strategy. On behalf of Department of the Environment and Local Government, Ireland.

    Wegman, F.C.M.

    2003-01-01

    SWOV has been requested to carry out a review of Ireland's Road Safety Strategy. This review should pay attention to three aspects: (1) review developments and progress made under the current National Road Safety Strategy 1998-2002; (2) place Ireland's performance in an appropriate international con

  19. Food Fraud Prevention: Policy, Strategy, and Decision-Making - Implementation Steps for a Government Agency or Industry.

    Spink, John; Fortin, Neal D; Moyer, Douglas C; Miao, Hong; Wu, Yongning

    2016-01-01

    This paper addresses the role of governments, industry, academics, and non-governmental organizations in Food Fraud prevention. Before providing strategic concepts for governments and authorities, definitions of Food Fraud are reviewed and discussed. Next there is a review of Food Fraud activities by the Global Food Safety Initiative (GFSI), the Elliott Review in the United Kingdom, the European Commission resolution on Food Fraud, and the US Food Safety Modernization Act including the Preventative Controls Rule. Two key concepts for governments or a company are: (1) formally, and specifically, mention food fraud as a food issue and (2) create an enterprise-wide Food Fraud prevention plan. The research includes a case study of the implementation of the concepts by a state or provincial agency. This analysis provides a foundation to review the role of science and technology in detection, deterrence and then contributing to prevention. PMID:27198808

  20. How Taxes Can Contribute to The Implementation of The Public Governance Strategy? – An Analysis for Eastern European Countries

    Vlad Cristina

    2016-09-01

    Full Text Available The paper begins with a short literature review regarding the public governance concept in the EU approach and its methods for establishing a common way to manage different situations for all member states; we discovered that the problems they confront with have to do with good governance and qualitative public administration. In the second part, we developed an econometric model for three Eastern European countries and we found a strong correlation between the total revenues from taxes and social contributions and total gross debt in 2002-2014 period. We ended the paper by emphasizing the conclusions obtained.

  1. Evaluating farmers’ adaptation strategies to climate change: A case study of Kaou local government area, Tahoua State, Niger Republic

    A. Moussa Tabbo

    2016-03-01

    Full Text Available The study discusses local farmers’ strategies of coping with and building resilience against the negative impact of climate change. Information for the discussion was from data collected using a set of structured questionnaires from interviews scheduled with 128 farmers. The questionnaire was based on previous literature and direct reconnaissance interview with farmers, which culminated in 13 strategies used for the study being reported. For each question, respondents were asked to choose their best and worst strategies. Thus, the difference between the best and worst strategies consistent with random utility theory has been used for the modelling. Results show that semi-transhumance, various handicrafts making, rural migration, small-scale vegetable production and small-scale river exploitation were the most important strategies identified, whilst water transport and vending, shifting cultivation, gypsum mining, gathering and trading of wild fruits and edible plants as well as cattle and sheep fattening were the least appreciated strategies identified amongst the farmers facing climate change. These findings are therefore imperative for planning farmers’ capacity-building and resilience against climate change projects to ensure sustainability in the study area.Keywords: Farmers’ adaptation strategies; Climate change resilience; Kaou

  2. 基于网络营销理念提升电子政务影响力的策略研究%The Promotion Strategy of E-government's Impact Based on Network Marketing

    李曼; 包文夏

    2014-01-01

    在电子政务的发展中,政府网站“重建设,轻服务”的现状影响了公众对电子政务信息和服务的获取。基于网络营销理念,提出SEO策略、网络推广策略、病毒营销策略、客户关系管理策略来提升电子政务的影响力。%In the development of e-government,situation government website"heavy construction,light service"affects public access to electronic government information and services.Based on network marketing,his article proposes 4 strategies to promote e-government's impact:SEO strategy,network marketing strategy,viral marketing strategy,customer relationship management strategy.

  3. Public Management Reform and Organizational Performance: An Empirical Assessment of the U.K. Labour Government's Public Service Improvement Strategy

    Walker, Richard M.; Boyne, George A.

    2006-01-01

    We present the first empirical assessment of the U.K. Labour government's program of public management reform. This reform program is based on rational planning, devolution and delegation, flexibility and incentives, and enhanced choice. Measures of these variables are tested against external and internal indicators of organizational performance.…

  4. MiR-21a-5p suppresses bisphenol A-induced pre-adipocyte differentiation by targeting map2k3 through MKK3/p38/MAPK.

    Xie, Xiuwen; Song, Jia; Li, Gang

    2016-04-22

    Childhood obesity is a metabolic disease characterized by accumulation of excessive fat. Bisphenol A (BPA), a potential obesogen compound, possesses an estrogen mimetic activity and endocrine disruption effect. MicroRNA-21a-5p (miR-21a-5p) is reported to regulate the adipogenic differentiation. Our study showed that miR-21a-5p overexpression significantly decreased the red lipid droplets and triglyceride level in BPA-induced 3T3-L1 cells. BPA induced the mRNA and protein expression levels of PPARγ, C/EBPα and adiponectin, and the induction was inhibited by miR-21a-5p mimics transfection. MiR-21a-5p mimics inhibited the GR activity, GR phosphorylation (S220, S21a-5p2, and S234), and the activation of p38/MAPK pathway, which are elevated by BPA treatment in 3T3-L1 cells. MiR-21a-5p overexpression inhibited the protein level of MKK3, but not in the mRNA level. Luciferase activity assay showed that miR-21a-5p directly targeted map2k3 3'-UTR. MKK3 overexpression attenuated the effect of miR-21a-5p mimics transfection on 3T3-L1 differentiation. We also assessed the body weight, fat mass and the content of serum lipid in rats subcutaneous injected with BPA and miR-21a-5p mimics. MiR-21a-5p overexpression attenuated BPA-induced obesity in vivo. These findings suggested that miR-21a-5p inhibited BPA induced adipocyte differentiation by targeting map2k3 through MKK3/p38/MAPK in 3T3-L1 cells, providing a potential therapeutic strategy for BPA induced obesity. PMID:26996129

  5. Stakeholder Governance

    Flak, Leif Skiftenes; Rose, Jeremy

    2005-01-01

    The e-government field, like most young fields, lacks a strong body of well-developed theory. One strategy for coping with theoretical immaturity is to import and adapt theories from other, more mature fields. This study reviews Stakeholder Theory (ST) and investigates its potential in relation to...... e-Government. Originally a management theory, stakeholder theory advocates addressing the concerns of all stakeholders in a firm, as opposed to concentration on the interests of senior managers and stockholders. Apart from the original profit focus, there is no serious conceptual mismatch between...... stakeholder theory and government’s objective of providing policy and services for citizens and organizations – society’s stakeholders. Potential problems with adapting a management theory to a government setting are discussed. The paper further discusses how information technology impacts a stakeholder model...

  6. Energy strategy 2050. From coal, oil and gas to green energy; Danish Government's energy policy; Energistrategi 2050 - fra kul, olie og gas til groen energi

    2011-02-15

    The Danish Government's ''Energy strategy 2050'' describes how the country can achieve its independence from coal, oil and gas by the year 2050 and significantly reduce its greenhouse gas emissions. The strategy contains a raft of initiatives that will reduce the energy industry's use of fossil fuels by 33 % in 2020, compared with 2009. The reduction will put Denmark well on its way to complete independence of fossil fuels by 2050. The strategy calls for a significant increase in renewable energy obtained from wind, biomass and biogas which over the next decade will increase the share of renewable to 33 % of energy consumption, if the initiatives in the strategy are implemented. The strategy offers an economically responsible path to the conversion of the Danish energy supply, and includes specific initiatives, that are all fully financed and which will not damage the nation's competitiveness. Homeowners will experience moderate increases in the costs of heat and electricity, but will also be given opportunities to lower their energy expenses through greater efficiency. Companies can expect added expenses amounting to 0.1 % of the rise in their gross revenue growth by 2020. (ln)

  7. Ion channel regulation by phosphoinositides analyzed with VSPs – PI(4,5P2 affinity, phosphoinositide selectivity, and PI(4,5P2 pool accessibility

    Alexandra eRjasanow

    2015-06-01

    Full Text Available The activity of many proteins depends on the phosphoinositide (PI content of the membrane. E.g., dynamic changes of the concentration of PI(4,5P2 are cellular signals that regulate ion channels. The susceptibility of a channel to such dynamics depends on its affinity for PI(4,5P2. Yet, measuring affinities for endogenous PIs has not been possible directly, but has relied largely on the response to soluble analogs, which may not quantitatively reflect binding to native lipids.Voltage-sensitive phosphatases (VSPs turn over PI(4,5P2 to PI(4P when activated by depolarization. In combination with voltage-clamp electrophysiology VSPs are useful tools for rapid and reversible depletion of PI(4,5P2. Because cellular PI(4,5P2 is resynthesized rapidly, steady state PI(4,5P2 changes with the degree of VSP activation and thus depends on membrane potential.Here we show that titration of endogenous PI(4,5P2 with Ci-VSP allows for the quantification of relative PI(4,5P2 affinities of ion channels. The sensitivity of inward rectifier and voltage-gated K+ channels to Ci-VSP allowed for comparison of PI(4,5P2 affinities within and across channel subfamilies and detected changes of affinity in mutant channels. The results also reveal that VSPs are useful only for PI effectors with high binding specificity among PI isoforms, because PI(4,5P2 depletion occurs at constant overall PI level. Thus, Kir6.2, a channel activated by PI(4,5P2 and PI(4P was insensitive to VSP.Surprisingly, despite comparable PI(4,5P2 affinity as determined by Ci-VSP, the Kv7 and Kir channel families strongly differed in their sensitivity to receptor-mediated depletion of PI(4,5P2. While Kv7 members were highly sensitive to activation of PLC by Gq-coupled receptors, Kir channels were insensitive even when PI(4,5P2 affinity was lowered by mutation. We hypothesize that different channels may be associated with distinct pools of PI(4,5P2 that differ in their accessibility to PLC and VSPs.

  8. Utilising Enterprise Risk Management Strategies to Develop a Governance and Operations Framework for a New Research Complex: A Case Study

    Clyde-Smith, Jodi

    2014-01-01

    Enterprise risk management strategies were used to develop a regulatory and operational framework for a new multi-partner Research Institute that will house up to 900 staff from four different institutions in Queensland, Australia. The Institute will operate in a business environment while functioning as a research resource for the higher…

  9. Cambodia Health System Review: The Current Policies and Strategies of the Health System’s Governance, Financing, and Service Delivery

    Peat, Steve

    2013-01-01

    Cambodia’s health system is in a period of transition as policy innovation and reform began in 1996. Importantly, the Ministry of Health (MoH) and donor agencies have undergone a series of policy shifts in an attempt to strengthen the health system in order to provide equitable access to health care for the population. This paper will describe the health system’s governance, financing and service delivery functions in regards to their current situation and recent innovations that aim to impro...

  10. MicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer (NSCLC) through down-regulation of CYP1B1.

    Mao, Ming; Wu, Zhouqing; Chen, Jiakuan

    2016-09-16

    Lung cancer remains a leading cause of cancer-associated mortality worldwide and non-small lung cancer (NSCLC) is responsible for over 80% of lung cancer-related deaths. Identifying novel molecular biomarker that can inhibit the progression of lung cancer will facilitate the development of new treatment strategies. Herein, we demonstrated that miR-187-5p is a tumor-suppressor miRNA in NSCLC progression. We found that expression of miR-187-5p was decreased obviously in NSCLC tissues. Down-regulation of miR-187-5p was associated with TNM stage and postoperative survival. Overexpression of miR-187-5p inhibited the growth and metastasis of NSCLC cells. The CYP1B1 was a direct target of miR-187-5p and promoted the growth and metastasis of NSCLC cells. Further study showed that CYP1B1 could reverse the inhibitory effect of miR-187-5p on growth and metastasis of NSCLC cells. Taken together, our data highlight the pivotal role of miR-187-5p in the progression of NSCLC. Thus, miR-187-5p may be a potential prognostic marker and of treatment relevance for NSCLC progression intervention. PMID:27495872

  11. Economic competitiveness and governance in areas of urban deprivation: the case study of two growth strategies in London.

    Bertotti, Marcello

    2008-01-01

    In an urban context characterised by concentrated and persistent deprivation there has been a history of policy intervention albeit with limited impact. Michael Porter's US inspired City Growth Strategy (CGS) initiative presented an alternative approach to urban economic regeneration within the UK characterised by a focus on the competitive advantages of deprived urban areas and a leading role for the private sector within the policy making process. This thesis investigates the implem...

  12. Good Governance i Cambodja

    Hansen, Thomas Kieler

    2012-01-01

    This project aims to asses the concept of governance, in reference to its use in the Cambodian development strategy. A theoretical analysis of the term, will determine how and in what manner the notion of governance relates to the field of developmental aid. An identification of the key concepts that relate to governance theory, will hereafter be applied to the Cambodian development strategy, in search of which focal points are hindering for the country’s development process. With the use of ...

  13. The government draft of the Combined Heat and Power Generation Act 2016. Exit strategy or prospects for the future?

    The combined heat and power (CHP) is in addition to renewable energy and energy efficiency a cornerstone for the transformation of the energy sector towards greater climate and environmental friendliness. Due to the situation in the energy markets currently plants operated with natural gas have come under pressure. Against the background of the critical economic situation of many gas-based cogeneration plants, it is therefore necessary, with a new combined heat and power law (CHP) to provide planning security for the plant operator. Meanwhile, there is a government draft of the Combined Heat and Power Generation Act in 2016, which includes far-reaching changes for the CHP. This article summarizes the most important changes.

  14. Brazilian policy responses to violence against women: government strategy and the help-seeking behaviors of women who experience violence.

    Kiss, Ligia; d'Oliveira, Ana Flavia Lucas; Zimmerman, Cathy; Heise, Lori; Schraiber, Lilia Blima; Watts, Charlotte

    2012-01-01

    Over the past three decades, international covenants have been signed and countries have implemented strategies and legislation to address violence against women. Concurrently, strong evidence on the magnitude and impact of violence against women has emerged from around the world. Despite a growing understanding of factors that may influence women's vulnerability to violence and its effects, key questions about intervention options persist. Using evidence from a WHO household survey on domestic violence, our paper discusses women's help-seeking patterns and considers these findings in relation to Brazil's policies and strategies on violence against women. For the WHO survey, data from a large urban center (the city of São Paulo) and from a rural region (Zona da Mata Pernambucana [ZMP]) was collected. Findings from this survey indicate that in São Paulo, only 33.8% of women who experienced intimate partner violence (IPV) sought help from a formal service provider, including health, legal, social, or women's support services; in the Forest Zone of the State of Pernambuco, an even smaller proportion (17.1%) sought formal assistance. The majority of women were likely to contact only informal sources of support, such as family, friends, and neighbors. Women who used formal services were primarily those who experienced more severe levels of violence, were severely injured, had children who witnessed the violence, or whose work was disrupted by the violence. Although Brazil adopted progressive laws and national and local strategies to address violence against women (VAW), messages about violence and equality need to reach informal networks and the wider community in order to national anti-violence policies to be successful in supporting women before violence becomes intolerable.. To translate international standards and national policies into actions that genuinely reach women experiencing violence, states must carefully consider evidence on women's options and decision

  15. Strategies to manage stream flow to benefit people and nature: a non-government conservation organisation's perspective.

    Pittock, J; Holland, R

    2004-01-01

    More than for any other biome, freshwater biodiversity is increasingly imperiled, particularly due to poor stream flow management and increasing demand for water diversions. The adoption by the world's governments of targets to extend water services to the poor and at the same time to conserve biodiversity increase the need to better direct investments in freshwater management. In this paper WWF draws on examples from its work to identify areas where investment can be focused to assure efficient water use and improve stream flow management, namely: Prioritize and target those river basins and sub-catchments that are most critical for conservation of freshwater biodiversity to maintain stream flows; Link strategic field, policy and market interventions at different scales in river basins to maximize the impact of interventions; Implement the World Commission on Dams guidelines to minimize investment in large scale and costly infrastructure projects; Apply market mechanisms and incentives for more sustainable production of the world's most water consuming crops Enhance statutory river basin management organizations to draw on their regulatory and financial powers; Implement international agreements, such as the Convention on Wetlands; Integrate environment and development policies. PMID:15195421

  16. Issue 3: Driving factors for nuclear industry strategies and choices. Accelerating the nuclear renaissance: Crucial roles for government and industry

    Ten years ago, the phrase 'nuclear renaissance' conveyed only a cautious hope within a narrow community of dedicated professionals. Today, the rebirth of nuclear energy has become an unmistakable reality that is gathering speed and momentum on the full world stage. This revitalisation is a composite of several developments: - Continuing evolutionary advance in reactor technology; - Multinational research efforts to produce quantum leaps in technology; - Unprecedented levels of efficiency and capacity utilisation in key countries; - A robust and accumulating record of operational safety, backed by the emergence of a global nuclear safety culture; - Political progress in implementing the scientifically sound concept of waste disposal using deep geological repositories; - And the truest barometer - expansive growth planning for nuclear power in major nations in both the developed and developing worlds. In countries representing the preponderance of world economic activity and world population - from North America across much of Europe to Russia and on to the leading countries of South and East Asia - the value of nuclear power has been reviewed and reaffirmed. Major countries without nuclear power - such as Poland, Turkey, and Vietnam - stand on the threshold of introducing nuclear energy for the first time; and even Italy, the one nation ever to suspend nuclear generation, now plans to reconsider. To be sure, anti-nuclear convictions can still be found: - In the mythologies that motivate many environmental groups; - In the assumptions of environmental journalists and bureaucrats; - In the rhetoric of some small countries like Denmark and Austria that are not inhibited by the hypocrisy of importing nuclear electricity, and - In the case of Germany, in the declaratory policy of a major country where a governing coalition is temporarily beholden to a small minority party. But all of these reactionary forces, taken together, are receding under the onslaught of facts that

  17. Global health governance and the commercial sector: a documentary analysis of tobacco company strategies to influence the WHO framework convention on tobacco control.

    Heide Weishaar

    governance. Awareness of these strategies can help guard against industry efforts to disrupt the implementation of the FCTC and support the development of future, comparable initiatives in global health.

  18. Strategy of Government-Oriented Tourism Development%我国政府主导型旅游业发展策略探析

    王珏

    2015-01-01

    At present, the rapid growth of China′s tourism industry continues to rise in the status of social development and national economy. But problems arise in the financial support, infrastructure, eco-tourism, intelligent tourism, resources sharing, environmental protection, coordination among travel security and other departments, industrial upgrading and industrial management. Thus, it is particularly important to give full play to the leading role of the government. The government should take the leading role and the dominant strategy in the tourism industry, which can sort and handle coordinating relations between the government and the tourism market, avoid blind investment and major mistakes, feasibly protect national tourism resources from destruction, and effectively guarantee the healthy and sustainable development of the tourism industry.%目前,我国旅游产业规模快速壮大,在社会发展和国民经济中的地位持续提升.但在发展的同时,也带来金融支持、基础建设、生态旅游、智能旅游、资源共享、环境保护、旅行安全等部门协调、产业升级及行业管理问题. 由此,充分发挥政府的主导作用尤为重要. 政府在旅游产业中的主导行为和采取的主导策略,能够梳理与处理协调好政府与旅游市场的关系,避免投资的盲目性与重大失误,切实保护国家旅游资源不被破坏,有效保证旅游产业健康有序的持续发展.

  19. Strengthening Voices: How patoralist communities and local government are shaping strategies for adaptive environmental management and poverty reduction in Tanzania's drylands

    Jode, Helen de; Hesse, Ced

    2011-06-15

    Across Tanzania, climate change is being felt in the changing patterns and intensity of rainfall, and in the growing unpredictability of the seasons. The drylands are being increasingly affected, and there is an urgent need to strengthen institutional capacity and good governance for drylands planning. Pastoralism provides over 90% of the meat and milk products consumed nationally in Tanzania. The pastoralist production system successfully exploits and adapts to the disequilibrium in the dryland ecosystems, but pastoralist voices are frequently excluded from the decision-making and management of dryland resources. The marginalisation of pastoralists is resulting in falling production levels. Since 2007, IIED, the Kimmage Development Studies Centre and the Tanzania Natural Resource Forum have been undertaking a project with their partners with the specific goal of generating more informed and equitable discussion and debate on pastoralism. Using local government reform processes, the 'Strengthening Voices' project works at the community, local government and national levels - addressing the lack of knowledge and power imbalances within all three. The central pillar of the project is a training course on the economic and ecological processes at the heart of pastoral systems — clarifying the rationale that underpins livelihood strategies. National politicians, local district officials and community participants have all benefited from the training. At the end of its 1st three-year phase good progress has been made in designing and implementing tools and approaches that promote citizen access to decision-making. With their new evidence, training and advocacy skills, people are now better able to inform policy of the economic and environmental benefits of dryland livelihood systems. This booklet and accompanying DVD explain the background to the project, its achievements, and how it plans to build on its successes to roll out the project to other districts in Tanzania

  20. 政府推进农村信息化策略探析%Strategy on Promoting Rural Informatization by Government

    程海梅

    2014-01-01

    Aiming at the problems in the construction of rural informatization, this article highlighted the government functions from the view of public management. According the practice of rural informatization construction in China, strategies for government on promoting rural informatization by adjusting measures to local conditions were proposed, including overall coordination, increasing investment, reducing cost, establishing standards, perfecting the system and personnel training, etc.%针对农村信息化建设中存在的问题,从公共管理角度突出政府职能发挥,结合我国农村信息化建设实际,从统筹协调、加大投入、降低成本、建立标准、完善体系和人才培养等角度为政府因地制宜地推进我国各地区信息化建设提出策略建议。

  1. miR-339-5p regulates the p53 tumor-suppressor pathway by targeting MDM2

    Jansson, M D; Djodji Damas, Nkerorema; Lees, M;

    2014-01-01

    MicroRNAs (miRNAs) regulate many key cancer-relevant pathways and may themselves possess oncogenic or tumor-suppressor functions. Consequently, miRNA dysregulation has been shown to be a prominent feature in many human cancers. The p53 tumor suppressor acts as a negative regulator of cell...... proliferation in response to stress and represents the most commonly lost and mutated gene in human cancers. The function of p53 is inhibited by the MDM2 oncoprotein. Using a high-throughput screening approach, we identified miR-339-5p as a regulator of the p53 pathway. We demonstrate that this regulation...... occurs via the ability of miR-339-5p to target directly the 3'-untranslated region of MDM2 mRNA, reducing MDM2 expression and thus promoting p53 function. Consequently, overexpression of miR-339-5p positively impacts on p53-governed cellular responses such as proliferation arrest and senescence, whereas...

  2. PRACTICE OF GOOD GOVERNANCE AND CORPORATE GOVERNANCE

    Bălăceanu Cristina

    2010-12-01

    Full Text Available Corporate governance reforms are occurring in countries around the globe and potentially impacting the population of the entire planet. In developing countries, such reforms occur in a larger context that is primarily defined by previous attempts at promoting “development” and recent processes of economic globalization. In this context, corporate governance reforms (in combination with the liberalising reforms associated with economic globalization, in effect represent a new development strategy for third world countries. The most basic questions that arise with respect to this situation are what the prospects for this new development model are and whether alternatives should be considered. Keywords: governance, corporate governance, economic globalization, development.

  3. 5p13 microduplication syndrome: a new case and better clinical definition of the syndrome.

    Novara, Francesca; Alfei, Enrico; D'Arrigo, Stefano; Pantaleoni, Chiara; Beri, Silvana; Achille, Valentina; Sciacca, Francesca L; Giorda, Roberto; Zuffardi, Orsetta; Ciccone, Roberto

    2013-01-01

    Chromosome 5p13 duplication syndrome (OMIM #613174), a contiguous gene syndrome involving duplication of several genes on chromosome 5p13 including NIPBL (OMIM 608667), has been described in rare patients with developmental delay and learning disability, behavioral problems and peculiar facial dysmorphisms. 5p13 duplications described so far present with variable sizes, from 0.25 to 13.6 Mb, and contain a variable number of genes. Here we report another patient with 5p13 duplication syndrome including NIPBL gene only. Proband's phenotype overlapped that reported in patients with 5p13 microduplication syndrome and especially that of subjects with smaller duplications. Moreover, we better define genotype-phenotype relationship associated with this duplication and confirmed that NIPBL was likely the major dosage sensitive gene for the 5p13 microduplication phenotype. PMID:23085304

  4. A 360-degree Data Governance Strategy for Medical Institutions%面向医疗机构的360°数据管控策略研究

    王斌; 李忠

    2012-01-01

    Objective To provide a 360-degree data governance strategy for medical institutions in order to further improve the medical information quality and access efficiency. Methods With the enterprise medical data warehouse as the basis platform, the accountability recognition mechanism of medical institutions internal data was perfected, and the active data governance was exerted with a 360-degree all-round view under data stewardship in the following areas: data quality, data integration, data security and privacy, metadata management, and master data management. Results Through this kind of full -spectrum data governance, medical institutions could greatly improve their information access efficiency and data quality, and finally step into a new elaborately-managed operational mode. Conclnsion In virtue of clear data monitoring, standardized workflow, and definitive data stewardship, this 360-degree data governance can help effectively and efficiently solve the data integration and data quality problems massively confronting medical institutions. [Chinese Medical Equipment Journal,2012,33(6) :45-48]%目的:为了进一步提高医疗数据质量和信息获取效率,提出一种面向医疗机构的360°全方位数据管控机制.方法:以企业级数据仓库为基础平台,完善医疗机构内部数据认责机制,并通过对数据质量、数据集成、数据安全与隐私、元数据管理、数据标准等细分层面的主动管控,以360°全方位视角完成整个医疗机构的数据管控.结果:通过这种全方位数据管控,医疗机构可以有效提升数据准确率和利用率,通过有效反馈,不断完善,最终步入精细化运营阶段.结论:360°全方位医疗数据管控平台通过监控数据流向、规范工作流程、明确数据职责,可以有效地解决异构系统集成问题,大幅度提升数据质量和数据访问效率.

  5. MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL

    Baraniskin, Alexander; Birkenkamp-Demtröder, Karin; Maghnouj, Abdelouahid;

    2012-01-01

    MicroRNAs (miRNAs) are small non-coding RNAs that are involved in different biological processes by suppressing target gene expression. Altered expression of miR-30a-5p has been reported in colon carcinoma. To elucidate its potential biological role in colon cancer, miR-30a-5p was overexpressed via...... partially rescued these cells from miR-30a-5p-mediated growth suppression. In addition, TP53 and CDKN1A expression were increased in miR-30a-5p-overexpressing HCT116 cells, suggesting that miR-30a-5p is able to modulate the cell cycle via a DTL-TP53-CDKN1A regulatory circuit. Finally, 379 colorectal cancer...

  6. "Growth without Governance"

    Kaufmann, Daniel; Kraay, Aart

    2002-01-01

    It is well known that there is a strong positive correlation between per capita incomes and the quality of governance across countries. the authors propose an empirical strategy that allows separation of this correlation into (1) a strong positive causal effect running from better governance to higher per capita incomes, and, perhaps surprisingly at first, (2) a weak and even negative caus...

  7. Urinary microRNA-30a-5p is a potential biomarker for ovarian serous adenocarcinoma.

    Zhou, Jun; Gong, Guanghui; Tan, Hong; Dai, Furong; Zhu, Xin; Chen, Yile; Wang, Junpu; Liu, Ying; Chen, Puxiang; Wu, Xiaoying; Wen, Jifang

    2015-06-01

    MicroRNAs (miRNAs) can serve as biomarkers in human cancer. To determine the clinical value of urinary miRNAs for ovarian serous adenocarcinoma, we collected urine samples from 39 ovarian serous adenocarcinoma patients, 26 patients with benign gynecological disease and 30 healthy controls. The miRNA microarray data showed that only miR-30a-5p was upregulated and 37 miRNAs were downregulated in the urine samples of ovarian serous adenocarcinoma patients, when compared to healthy controls, which was confirmed after conducting quantitative PCR. The upregulation of urinary miR-30a-5p was closely associated with early stage of ovarian serous adenocarcinoma as well as lymphatic metastasis. Receiver operator characteristic (ROC) analysis demonstrated the potential use of urinary miR-30a-5p as a diagnostic marker for ovarian serous adenocarcinoma. Furthermore, a lower urine level of miR-30a-5p was found in 20 gastric cancer and 20 colon carcinoma patients when compared to ovarian serous adenocarcinoma, suggesting that the upregulation of urinary miR-30a-5p may be specific for ovarian serous adenocarcinoma. miR-30a-5p was also upregulated in ovarian serous adenocarcinoma tissues and cell lines, while urinary miR-30a-5p from ovarian cancer patients was notably reduced following the surgical removal of ovarian serous adenocarcinoma, suggesting that urinary miR-30a-5p was derived from the ovarian serous adenocarcinoma tissue. Notably, miR-30a-5p was concentrated with exosomes from the ovarian cancer cell supernatant or urine from ovarian serous adenocarcinoma patients, supporting a pathway for excretion into the urine. The results also showed that the knockdown of miR-30a-5p significantly inhibited the proliferation and migration of ovarian cancer cells. In summary, to the best of our knowledge, the present study provided the first evidence of increased miR-30a-5p in the urine of ovarian serous adeno-carcinoma patients, while the inhibition of miR-30a-5p suppressed the

  8. PRACTICE OF GOOD GOVERNANCE AND CORPORATE GOVERNANCE

    BĂLĂCEANU, Cristina; TILEA, Doina; Andreea-Monica PREDONU

    2010-01-01

    Corporate governance reforms are implemented around the world and may impact upon the population worldwide. In developing countries, such reforms are implemented in a broader context that is primarily defined by previous attempts of promoting “development” and recent processes of economic globalization. In this context, corporate governance reforms (in combination with the liberalization reforms associated with the economic globalization), in effect, represent a new development strategy for t...

  9. Governing Engineering

    Buch, Anders

    2011-01-01

    Abstract: Most people agree that our world faces daunting problems and, correctly or not, technological solutions are seen as an integral part of an overall solution. But what exactly are the problems and how does the engineering ‘mind set’ frame these problems? This chapter sets out to unravel...... dominant perspectives in challenge perception in engineering in the US and Denmark. Challenge perception and response strategies are closely linked through discursive practices. Challenge perceptions within the engineering community and the surrounding society are thus critical for the shaping of...... engineering education and the engineering profession. Through an analysis of influential reports and position papers on engineering and engineering education the chapter sets out to identify how engineering is problematized and eventually governed. Drawing on insights from governmentality studies the chapter...

  10. Governance Strategies and Welfare Effects

    Trifkovic, Neda

    Using an original dataset from the Vietnamese catfish sector, we study the impact of vertical coordination options on household welfare and the implications of different stages of vertical coordination for the success of the whole sector. The welfare gain from contract farming and employment on...... processor-owned estate farms is estimated using a maximum simulated likelihood estimator. Our results show positive welfare effects from participating in contract farming, but not from employment on processor-owned estate farms. The results imply that contract farming presents opportunities for economic...

  11. Iterative Precision Measurement of Branching Ratios Applied to 5P states in 88Sr+

    Zhang, Helena; Low, Guang Hao; Rines, Richard; Stuart, Jules; Wu, Tailin; Chuang, Isaac

    2016-01-01

    We report on a method for measuring the branching ratios of dipole transitions of trapped atomic ions by performing nested sequences of population inversions. This scheme is broadly applicable and does not use ultrafast pulsed or narrow linewidth lasers. It is simple to perform and insensitive to experimental variables such as laser and magnetic field noise as well as ion heating. To demonstrate its effectiveness, we make the most accurate measurements thus far of the branching ratios of both 5P1/2 and 5P3/2 states in 88Sr+ with sub-1% uncertainties. We measure 17.175(27) for the branching ratio of 5P1/2-5S1/2, 15.845(71) for 5P3/2-5S1/2, and 0.05609(21) for 5P3/2-4D5/2, ten- fold and thirty-fold improvements in precision for 5P1/2 and 5P3/2 branching ratios respectively over the best previous experimental values.

  12. The Role of Government and Markets in the Strategy “Europe 2020” of the European Union: A Robust Political Economy Analysis

    Wandel Jürgen

    2016-03-01

    Full Text Available The EU’s current ten year strategy “Europe 2020” aims to set out a vision of a European social market economy for the 21st century that will promote economic growth with social and ecological attributes. This article analyzes the roles ascribed to the government and the market and the extent this role allocation is suitable to enhance growth of the European Union’s member states. Based on a robust political economy framework it is argued that this new economic policy concept is in essence a technocratic approach and a form of selective interventionism. As such it suffers from three major shortcomings: (1 it underestimates the difficulties of gathering and analyzing the relevant information necessary for steering the economy in the desired direction, (2 it encourages rent-seeking rather than productive entrepreneurship, and (3 it may cause a subtle transformation of the societal order through the diminution of individual liberties. It is contended that while an interventionist policy approach meets the preferences of large parts of the population, not the least in Germany, it is unlikely to boost economic growth and employment in the EU.

  13. A p53-dependent tumor suppressor network is induced by selective miR-125a-5p inhibition in multiple myeloma cells.

    Leotta, Marzia; Biamonte, Lavinia; Raimondi, Lavinia; Ronchetti, Domenica; Di Martino, Maria Teresa; Botta, Cirino; Leone, Emanuela; Pitari, Maria Rita; Neri, Antonino; Giordano, Antonio; Tagliaferri, Pierosandro; Tassone, Pierfrancesco; Amodio, Nicola

    2014-12-01

    The analysis of deregulated microRNAs (miRNAs) is emerging as a novel approach to disclose the regulation of tumor suppressor or tumor promoting pathways in tumor cells. Targeting aberrantly expressed miRNAs is therefore a promising strategy for cancer treatment. By miRNA profiling of primary plasma cells from multiple myeloma (MM) patients, we previously reported increased miR-125a-5p levels associated to specific molecular subgroups. On these premises, we aimed at investigating the biological effects triggered by miR-125a-5p modulation in MM cells. Expression of p53 pathway-related genes was down-regulated in MM cells transfected with miR-125a-5p mimics. Luciferase reporter assays confirmed specific p53 targeting at 3'UTR level by miR-125a-5p mimics. Interestingly, bone marrow stromal cells (BMSCs) affected the miR-125a-5p/p53 axis, since adhesion of MM cells to BMSCs strongly up-regulated miR-125a-5p levels, while reduced p53 expression. Moreover, ectopic miR-125a-5p reduced, while miR-125-5p inhibitors promoted, the expression of tumor suppressor miR-192 and miR-194, transcriptionally regulated by p53. Lentiviral-mediated stable inhibition of miR-125a-5p expression in wild-type p53 MM cells dampened cell growth, increased apoptosis and reduced cell migration. Importantly, inhibition of in vitro MM cell proliferation and migration was also achieved by synthetic miR-125a-5p inhibitors and was potentiated by the co-expression of miR-192 or miR-194. Taken together, our data indicate that miR-125a-5p antagonism results in the activation of p53 pathway in MM cells, underlying the crucial role of this miRNA in the biopathology of MM and providing the molecular rationale for the combinatory use of miR-125a inhibitors and miR-192 or miR-194 mimics for MM treatment. PMID:24819167

  14. Dynamics of receptor-operated Ca2+ Currents Through TRPC Channels Controlled via the PI(4,5P2-PLC Signaling Pathway

    Masayuki X Mori

    2015-02-01

    Full Text Available Transient receptor potential canonical (TRPC channels are Ca2+-permeable, nonselective cation channels that carry receptor-operated Ca2+ currents (ROCs triggered by receptor-induced, phospholipase C (PLC-catalyzed hydrolysis of phosphatidylinositol 4,5-bisphosphate (PI(4,5P2. Within the vasculature, TRPC channel ROCs contribute to smooth muscle cell depolarization, vasoconstriction and vascular remodeling. However, TRPC channel ROCs exhibit a variable response to receptor-stimulation, and the regulatory mechanisms governing TRPC channel activity remain obscure. The variability of ROCs may be explained by their complex regulation by PI(4,5P2 and its metabolites, which differentially affect TRPC channel activity. To resolve the complex regulation of ROCs, the use of voltage-sensing phosphoinositide phosphatases and model simulation have helped to reveal the time-dependent contribution of PI(4,5P2 and the possible role of PI(4,5P2 in the regulation of ROCs. These approaches may provide unprecedented insight into the dynamics of PI(4,5P2 regulation of TRPC channels and the fundamental mechanisms underlying transmembrane ion flow. Within that context, we summarize the regulation of TRPC channels and their coupling to receptor-mediated signaling, as well as the application of voltage-sensing phosphoinositide phosphatases to this research. We also discuss the controversial bidirectional effects of PI(4,5P2 using a model simulation that could explain the complicated effects of PI(4,5P2 on different ROCs.

  15. Consultancy support to GCC ICT Authorities to assist in creating common guidelines and strategies to enhance the development of eGovernment within the eGULF Initiative: final report

    J. Millard; J. Shahin

    2010-01-01

    This consultancy support analyses global experience in eGovernment cooperation between responsible authorities, examines the needs and existing strategies of each of the six GCC Countries, identifies common elements and areas where mutual cooperation will be beneficial, and proposes common guideline

  16. Enterprise IT governance key decision-making based on strategy alignment and analytic hierarchy process%基于战略匹配和层次分析的企业IT治理关键问题决策

    计春阳; 唐志豪

    2012-01-01

    The alignment between business strategy and IT strategy is the bases for good IT governance performance. And enterprises have to do five key decisions for their IT governance. To convert the alignment ideal into quantitative model so as to support enterprise IT governance decision, the Analytic Network Process (ANP) algorithm was introduced , and collaboration between business and IT strategy was simulated. Business strategy management of Porter, and strategy alignment management of Henderson were borrowed to represent business strategy and IT strategy. An IT governance key decision-making model based on the quantitative results of strategic alignment was put forward and validated through computation and analysis of real cases.%企业战略与IT战略之间的匹配是确保IT治理取得良好绩效的重要前提.企业的IT治理必须完成五个关键问题的决策.为有效地将战略对应的思想转化为量化模型,支持企业决策,本文引入网络层次分析法模拟企业战略与IT战略之间的匹配关系,分别借用Porter的战略管理理论和Henderson的战略匹配模型代表企业战略和IT战略,提出了基于战略匹配的企业IT治理五个关键问题决策模型,并通过实例分析与运算验证了该模型的有效性.

  17. Electron-impact ionization of laser-excited Ba-138 (... 5p6 6s 6p) and Ba-138 (... 5p6 6s 5d) atoms

    Trajmar, S.; Nickel, J. C.; Antoni, T.

    1986-01-01

    Electron-impact ionization cross sections for laser-excited Ba-138 (... 5p6 6s 6p; 1P1, M = - 1) and cascade-populated Ba-138 (... 5p6 6s 5d; 1D + 3D) atoms were measured in the threshold to 10 eV energy range. The peak cross sections for the excited species are about a factor of 2 larger than that for ground-state Ba. In addition, it was demonstrated that ionization from individual magnetic substates of various hyperfine levels can be studied. The ionization cross sections in the case of Ba-138 (1P1) were found to be equal for the M = 0 and for the M = + or - 1 sublevels within the experimental error limit.

  18. Energy-Pooling Collisions in Rubidium: 5P3/2+ 5P3/2 → 5S + (nl = 5D, 7S)

    SHEN Yi-Fan; DAI Kang; MU Bao-Xia; WANG Shu-Ying; CUI Xiu-Hua

    2005-01-01

    @@ We experimentally study rubidium energy pooling collisions of Rb(5P3/2) + Rb(5P3/2) → Rb(5S1/2) + Rb (nlJ =5DJ, 7S1/2) at low densities in a cell using diode laser excitation. The excited-atom density and spatial distribution are mapped by monitoring the absorption of a counterpropagating single-mode diode laser beam, tuned to the 5P3/2 → 7S1/2 transition, which could be translated parallel to the pump beam. The excited atom densities are combined with measured fluorescence ratios to determine cross sections for the rubidium energy pooling process.The cross sections for nlJ being 5D5/2, 5D3/2, and 7S1/2 are (1.32 ± 0.59) × 10-14, (1.18 ± 0.53) × 10-14 and (3.21 ± 1.44) × 10-15 cm2, respectively.

  19. Involvement of aberrant cyclin-dependent kinase 5/p25 activity in experimental traumatic brain injury.

    Yousuf, Mohammad A; Tan, Chunfeng; Torres-Altoro, Melissa I; Lu, Fang-Min; Plautz, Erik; Zhang, Shanrong; Takahashi, Masaya; Hernandez, Adan; Kernie, Steven G; Plattner, Florian; Bibb, James A

    2016-07-01

    Traumatic brain injury (TBI) is associated with adverse effects on brain functions, including sensation, language, emotions and/or cognition. Therapies for improving outcomes following TBI are limited. A better understanding of the pathophysiological mechanisms of TBI may suggest novel treatment strategies to facilitate recovery and improve treatment outcome. Aberrant activation of cyclin-dependent kinase 5 (Cdk5) has been implicated in neuronal injury and neurodegeneration. Cdk5 is a neuronal protein kinase activated via interaction with its cofactor p35 that regulates numerous neuronal functions, including synaptic remodeling and cognition. However, conversion of p35 to p25 via Ca(2+) -dependent activation of calpain results in an aberrantly active Cdk5/p25 complex that is associated with neuronal damage and cell death. Here, we show that mice subjected to controlled cortical impact (CCI), a well-established experimental TBI model, exhibit increased p25 levels and consistently elevated Cdk5-dependent phosphorylation of microtubule-associated protein tau and retinoblastoma (Rb) protein in hippocampal lysates. Moreover, CCI-induced neuroinflammation as indicated by increased astrocytic activation and number of reactive microglia. Brain-wide conditional Cdk5 knockout mice (Cdk5 cKO) subjected to CCI exhibited significantly reduced edema, ventricular dilation, and injury area. Finally, neurophysiological recordings revealed that CCI attenuated excitatory post-synaptic potential field responses in the hippocampal CA3-CA1 pathway 24 h after injury. This neurophysiological deficit was attenuated in Cdk5 cKO mice. Thus, TBI induces increased levels of p25 generation and aberrant Cdk5 activity, which contributes to pathophysiological processes underlying TBI progression. Hence, selectively preventing aberrant Cdk5 activity may be an effective acute strategy to improve recovery from TBI. Traumatic brain injury (TBI) increases astrogliosis and microglial activation

  20. LPS-induced clustering of CD14 triggers generation of PI(4,5)P2.

    Płóciennikowska, Agnieszka; Zdioruk, Mykola I; Traczyk, Gabriela; Świątkowska, Anna; Kwiatkowska, Katarzyna

    2015-11-15

    Bacterial lipopolysaccharide (LPS) induces strong pro-inflammatory reactions after sequential binding to CD14 protein and TLR4 receptor. Here, we show that CD14 controls generation of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] in response to LPS binding. In J774 cells and HEK293 cells expressing CD14 exposed to 10-100 ng/ml LPS, the level of PI(4,5)P2 rose in a biphasic manner with peaks at 5-10 min and 60 min. After 5-10 min of LPS stimulation, CD14 underwent prominent clustering in the plasma membrane, accompanied by accumulation of PI(4,5)P2 and type-I phosphatidylinositol 4-phosphate 5-kinase (PIP5K) isoforms Iα and Iγ (encoded by Pip5k1a and Pip5k1c, respectively) in the CD14 region. Clustering of CD14 with antibodies, without LPS and TLR4 participation, was sufficient to trigger PI(4,5)P2 elevation. The newly generated PI(4,5)P2 accumulated in rafts, which also accommodated CD14 and a large portion of PIP5K Iα and PIP5K Iγ. Silencing of PIP5K Iα and PIP5K Iγ, or application of drugs interfering with PI(4,5)P2 synthesis and availability, abolished the LPS-induced PI(4,5)P2 elevation and inhibited downstream pro-inflammatory reactions. Taken together, these data indicate that LPS induces clustering of CD14, which triggers PI(4,5)P2 generation in rafts that is required for maximal pro-inflammatory signaling of TLR4. PMID:26446256

  1. Does Candida albicans Als5p Amyloid Play a Role in Commensalism in Caenorhabditis elegans?

    Bois, Michael; Singh, Sean; Samlalsingh, Alyssa; Lipke, Peter N.; Garcia, Melissa C.

    2013-01-01

    Candida albicans, a dimorphic fungus and an opportunistic pathogen, possesses a myriad of adherence factors, including members of the agglutinin-like sequence (Als) family of mannoproteins. The adhesin Als5p mediates adhesion to many substrates and is upregulated during commensal interactions but is downregulated during active C. albicans infections. An amyloid-forming core sequence at residues 325 to 331 is important for Als5p function, because a single-amino-acid substitution at position 32...

  2. Methylation of miR-145a-5p promoter mediates adipocytes differentiation.

    Du, Jingjing; Cheng, Xiao; Shen, Linyuan; Tan, Zhendong; Luo, Jia; Wu, Xiaoqian; Liu, Chendong; Yang, Qiong; Jiang, Yanzhi; Tang, Guoqing; Li, Xuewei; Zhang, Shunhua; Zhu, Li

    2016-06-17

    MicroRNAs (miRNAs, miR) play important roles in adipocyte development. Recent studies showed that the expression of several miRNAs is closely related with promoter methylation. However, it is not known whether miRNA mediates adipocytes differentiation by means of DNA methylation. Here, we showed that miR-145a-5p was poorly expressed in adipose tissue from mice fed a high fat diet (HFD). Overexpression or inhibition of miR-145a-5p was unfavorable or beneficial, respectively, for adipogenesis, and these effects were achieved by regulating adipocyte-specific genes involved in lipogenic transcription, fatty acid synthesis, and fatty acid transportation. Particularly, we first suggested that miR-145a-5p mimics or inhibitors promoted or repressed adipocytes proliferation by regulating p53 and p21, which act as cell cycle regulating factors. Surprisingly, the miR-145a-5p-repressed adipocyte differentiation was enhanced or rescued when cells treated with 5-Aza-dC were transfected with miR-145a-5p mimics or inhibitors, respectively. These data indicated that, as a new mean to positively regulate adipocyte proliferation, the process of miR-145a-5p-inhibited adipogenesis may be regulated by DNA methylation. PMID:27179777

  3. Interactive governance

    Sørensen, Eva; Torfing, Jacob; Peters, B. Guy;

    Governance has become one of the most commonly used concepts in contemporary political science. It is, however, often used to mean a variety of different things. This book helps to clarify this conceptual muddle by concentrating on one variety of governance-interactive governance. The authors argue...... that although the state may remain important for many aspects of governing, interactions between state and society represent an important, and perhaps increasingly important, dimension of governance. These interactions may be with social actors such as networks, with market actors or with other...... governments, but all these forms represent means of governing involving mixtures of state action with the actions of other entities.This book explores thoroughly this meaning of governance, and links it to broader questions of governance. In the process of explicating this dimension of governance the authors...

  4. Targeting of multiple myeloma-related angiogenesis by miR-199a-5p mimics: in vitro and in vivo anti-tumor activity.

    Raimondi, Lavinia; Amodio, Nicola; Di Martino, Maria Teresa; Altomare, Emanuela; Leotta, Marzia; Caracciolo, Daniele; Gullà, Annamaria; Neri, Antonino; Taverna, Simona; D'Aquila, Patrizia; Alessandro, Riccardo; Giordano, Antonio; Tagliaferri, Pierosandro; Tassone, Pierfrancesco

    2014-05-30

    Multiple myeloma (MM) cells induce relevant angiogenic effects within the human bone marrow milieu (huBMM) by the aberrant expression of angiogenic factors. Hypoxia triggers angiogenic events within the huBMM and the transcription factor hypoxia-inducible factor-1α (HIF-1α) is over-expressed by MM cells. Since synthetic miR-199a-5p mimics negatively regulates HIF-1α, we here investigated a miRNA-based therapeutic strategy against hypoxic MM cells. We indeed found that enforced expression of miR-199a-5p led to down-modulated expression of HIF-1α as well as of other pro-angiogenic factors such as VEGF-A, IL-8, and FGFb in hypoxic MM cells in vitro. Moreover, miR-199a-5p negatively affected MM cells migration, while it increased the adhesion of MM cells to bone marrow stromal cells (BMSCs) in hypoxic conditions. Furthermore, transfection of MM cells with miR-199a-5p significantly impaired also endothelial cells migration and down-regulated the expression of endothelial adhesion molecules such as VCAM-1 and ICAM-1. Finally, we identified a hypoxia\\AKT/miR-199a-5p loop as a potential molecular mechanism responsible of miR-199a-5p down-regulation in hypoxic MM cells. Taken together our results indicate that miR-199a-5p has an important role for the pathogenesis of MM and support the hypothesis that targeting angiogenesis via a miRNA/HIF-1α pathway may represent a novel potential therapeutical approach for this still lethal disease. PMID:24839982

  5. IT GOVERNANCE AND BUSINESS CORPORATE STRATEGY – BASED ON EMBEDDING THE PROGRAM AND PROJECT MANAGEMENT WITH THE IT&C VALUE CHAIN

    Mihail Sădeanu

    2009-01-01

    This paper presents the key concepts related to the current process of IT Governance in modern corporations. The first part addresses the definitions of IT Governance and its life-cycle model, the covered strategic areas and the effective governance management ways, the IT value management for ensuring value delivery, and the IT value chain based on projects and programs together with the organizational value of the IT&C programs and projects. The second part deals with the IT value chain bas...

  6. Membrane association of the cycling peroxisome import receptor Pex5p.

    Kerssen, Daniela; Hambruch, Eva; Klaas, Wibke; Platta, Harald W; de Kruijff, Ben; Erdmann, Ralf; Kunau, Wolf-H; Schliebs, Wolfgang

    2006-09-15

    Peroxisomal proteins carrying a peroxisome targeting signal type 1 (PTS1) are recognized in the cytosol by the cycling import receptor Pex5p. The receptor-cargo complex docks at the peroxisomal membrane where it associates with multimeric protein complexes, referred to as the docking and RING finger complexes. Here we have identified regions within the Saccharomyces cerevisiae Pex5p sequence that interconnect the receptor-cargo complex with the docking complex. Site-directed mutagenesis of the conserved tryptophan residue within a reverse WXXXF motif abolished two-hybrid binding with the N-terminal half of Pex14p. In combination with an additional mutation introduced into the Pex13p-binding site, we generated a Pex5p mutant defective in a stable association not only with the docking complex but also with the RING finger peroxins at the membrane. Surprisingly, PTS1 proteins are still imported into peroxisomes in these mutant cells. Because these mutations had no significant effect on the membrane binding properties of Pex5p, we examined yeast and human Pex5p for intrinsic lipid binding activity. In vitro analyses demonstrated that both proteins have the potential to insert spontaneously into phospholipid membranes. Altogether, these data strongly suggest that a translocation-competent state of the PTS1 receptor enters the membrane via protein-lipid interactions before it tightly associates with other peroxins. PMID:16849337

  7. PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms.

    Mironova, Yevgeniya A; Lenk, Guy M; Lin, Jing-Ping; Lee, Seung Joon; Twiss, Jeffery L; Vaccari, Ilaria; Bolino, Alessandra; Havton, Leif A; Min, Sang H; Abrams, Charles S; Shrager, Peter; Meisler, Miriam H; Giger, Roman J

    2016-01-01

    Proper development of the CNS axon-glia unit requires bi-directional communication between axons and oligodendrocytes (OLs). We show that the signaling lipid phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2] is required in neurons and in OLs for normal CNS myelination. In mice, mutations of Fig4, Pikfyve or Vac14, encoding key components of the PI(3,5)P2 biosynthetic complex, each lead to impaired OL maturation, severe CNS hypomyelination and delayed propagation of compound action potentials. Primary OLs deficient in Fig4 accumulate large LAMP1(+) and Rab7(+) vesicular structures and exhibit reduced membrane sheet expansion. PI(3,5)P2 deficiency leads to accumulation of myelin-associated glycoprotein (MAG) in LAMP1(+)perinuclear vesicles that fail to migrate to the nascent myelin sheet. Live-cell imaging of OLs after genetic or pharmacological inhibition of PI(3,5)P2 synthesis revealed impaired trafficking of plasma membrane-derived MAG through the endolysosomal system in primary cells and brain tissue. Collectively, our studies identify PI(3,5)P2 as a key regulator of myelin membrane trafficking and myelinogenesis. PMID:27008179

  8. Identification of miR-194-5p as a potential biomarker for postmenopausal osteoporosis

    Jia Meng

    2015-05-01

    Full Text Available The incidence of osteoporosis is high in postmenopausal women due to altered estrogen levels and continuous calcium loss that occurs with aging. Recent studies have shown that microRNAs (miRNAs are involved in the development of osteoporosis. These miRNAs may be used as potential biomarkers to identify women at a high risk for developing the disease. In this study, whole blood samples were collected from 48 postmenopausal Chinese women with osteopenia or osteoporosis and pooled into six groups according to individual T-scores. A miRNA microarray analysis was performed on pooled blood samples to identify potential miRNA biomarkers for postmenopausal osteoporosis. Five miRNAs (miR-130b-3p, -151a-3p, -151b, -194-5p, and -590-5p were identified in the microarray analysis. These dysregulated miRNAs were subjected to a pathway analysis investigating whether they were involved in regulating osteoporosis-related pathways. Among them, only miR-194-5p was enriched in multiple osteoporosis-related pathways. Enhanced miR-194-5p expression in women with osteoporosis was confirmed by quantitative reverse transcription–polymerase chain reaction analysis. For external validation, a significant correlation between the expression of miR-194-5p and T-scores was found in an independent patient collection comprised of 24 postmenopausal women with normal bone mineral density, 30 postmenopausal women with osteopenia, and 32 postmenopausal women with osteoporosis (p < 0.05. Taken together, the present findings suggest that miR-194-5p may be a viable miRNA biomarker for postmenopausal osteoporosis.

  9. Nanotechnology governance

    Kurath, Monika

    2010-01-01

    Current discourses in science, technology and innovation policy describe a shift from formal, governmental, or statutory regulation to non-hierarchical, informal, and cooperative self-regulatory approaches. They narrate a turn from government to governance, described as a “governance turn.” Governance as a new and popular mode of regulation, deliberation and shared responsibility is often linked to favored attributes of science and technology development, and policy making such as democracy a...

  10. The Knowledge Governance Approach

    Nicolai J. Foss

    2005-01-01

    An attempt is made to characterize a "knowledge governance approach" as a distinctive, emerging field that cuts across the fields of knowledge management, organisation studies, strategy and human resource management. Knowledge governance is taken up with how the deployment of administrative apparatus influences knowledge processes, such as sharing, retaining and creating knowledge. It insists on clear behavioural foundations, adopts an economizing perspective and examines efficient alignment ...

  11. Program governance

    Khan, Muhammad Ehsan

    2014-01-01

    FOUNDATION OF GOVERNANCEGovernanceDefining GovernanceGovernance at Multiple LevelsSummaryReferencesTransaction Cost EconomicsTransactions-Core Elements and Attributes     Behavioral Assumptions     Governance Structure AttributesHazards of Concern     Incomplete Contracting     Bilateral Dependency and Fundamental Transformation     Adaptation or MaladaptationLinking Governance, Governance Structures, and ContractsThe Impact of Asset Specificity and Behavioral Assumptions on ContractsAp

  12. Plural Governance

    Mols, Niels Peter; Menard, Claude

    2014-01-01

    Plural governance is a form of governance where a firm both makes and buys similar goods or services. Despite a widespread use of plural governance there are no transaction cost models of how plural governance affects performance. This paper reviews the literature about plural forms and proposes a...... model relating transaction cost and resource-based variables to the cost of the plural form. The model is then used to analyze when the plural form is efficient compared to alternative governance structures. We also use the model to discuss the strength of three plural form synergies....

  13. Rose Atoll Site 5P 2/10/2004 30-29M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Rose Atoll, site 5P (14 33.280 S, 168 09.878 W), between 30 and 31 meters along a permanent transect.

  14. Rose Atoll Site 5P 2/20/2002 28-29M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Rose Atoll, site 5P (14 33.280S, 168 09.878W), between 28 and 29 meters along a permanent transect.

  15. Rose Atoll Site 5P 2/10/2004 10-9M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Rose Atoll, site 5P (14 33.280 S, 168 09.878 W), between 10 and 11 meters along a permanent transect.

  16. Rose Atoll Site 5P 2/10/2004 47-46M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Rose Atoll, site 5P (14 33.280 S, 168 09.878 W), between 47 and 48 meters along a permanent transect.

  17. Baker Island Site 5P 1/24/2004 16-17M

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Baker Island, site 5P 00 11.781N, 176 29.176W, between 16 and 17 meters along a permanent transect.

  18. Howland Island Site 5P 1/21/2004 47-48M

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Howland Island, site 5P 00 48.340 N, 176 37.272 W, between 47 and 48 meters along a permanent transect.

  19. Closure of the telephone switchboard at 5 p.m. on 20 December

    Communications Support Section

    2013-01-01

    Exceptionally, the telephone switchboard will close at 5 p.m. on Friday 20 December, instead of 6 p.m. (usual time), to allow time for all systems to be properly closed before the annual closure.   Therefore, switchboard operator assistance to transfer calls from/to external lines will cease. All other phone services will run as usual.

  20. Howland Island Site 5P 1/21/2004 17-18M

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Howland Island, site 5P 00 48.340 N, 176 37.272 W, between 17 and 18 meters along a permanent transect.

  1. Baker Island Site 5P 3/19/2000 30-31M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Baker Island, site 5P (00 11.781N, 176 29.176W), between 30 and 31 meters along a permanent transect.

  2. Howland Island Site 5P 3/17/2000 78-79M

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Howland Island, site 5P 00 48.340 N, 176 37.272 W, between 78 and 79 meters along a permanent transect.

  3. Kingman Reef Site 5P 3/17/2002 33-34M

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Kingman Reef, site 5P 6 23.805N, 162 20.941W, between 33 and 34 meters along a permanent transect.

  4. Howland Island Site 5P 2/7/2001 32-33M

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Howland Island, site 5P 0 48.340 N, 176 37.272 W, between 32 and 33 meters along a permanent transect.

  5. Baker Island Site 5P 1/24/2004 13-14M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Baker Island, site 5P (00 11.781N, 176 29.176W), between 13 and 14 meters along a permanent transect.

  6. Baker Island Site 5P 3/19/2000 55-56M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Baker Island, site 5P (00 11.781N, 176 29.176W), between 55 and 56 meters along a permanent transect.

  7. Kingman Reef Site 5P 4/1/2000 60-61M

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Kingman Reef, site 5P 06 23.805N, 162 20.941W, between 60 and 61 meters along a permanent transect.

  8. Howland Island Site 5P 3/17/2000 60-61M

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Howland Island, site 5P 00 48.340 N, 176 37.272 W, between 60 and 61 meters along a permanent transect.

  9. Baker Island Site 5P 3/19/2000 60-61M

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Baker Island, site 5P 00 11.781N, 176 29.176W, between 60 and 61 meters along a permanent transect.

  10. Baker Island Site 5P 2/9/2001 60-61M

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Baker Island, site 5P 0 11.781N, 176 29.176W, between 60 and 61 meters along a permanent transect.

  11. Rose Atoll Site 5P 2/10/2004 40-39M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Rose Atoll, site 5P (14 33.280 S, 168 09.878 W), between 40 and 41 meters along a permanent transect.

  12. Howland Island Site 5P 1/21/2004 6-7M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Howland Island, site 5P (00 48.340 N, 176 37.272 W), between 6 and 7 meters along a permanent transect.

  13. Howland Island Site 5P 1/21/2004 40-41M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Howland Island, site 5P (00 48.340 N, 176 37.272 W), between 40 and 41 meters along a permanent transect.

  14. Howland Island Site 5P 1/21/2004 43-44M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Howland Island, site 5P (00 48.340 N, 176 37.272 W), between 43 and 44 meters along a permanent transect.

  15. Howland Island Site 5P 1/21/2004 7-8M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Howland Island, site 5P (00 48.340 N, 176 37.272 W), between 7 and 8 meters along a permanent transect.

  16. Howland Island Site 5P 1/21/2004 11-12M

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Howland Island, site 5P 00 48.340 N, 176 37.272 W, between 11 and 12 meters along a permanent transect.

  17. Baker Island Site 5P 1/24/2004 25-26M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Baker Island, site 5P (00 11.781N, 176 29.176W), between 25 and 26 meters along a permanent transect.

  18. Kingman Reef Site 5P 4/1/2000 81-82M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (06 23.805N, 162 20.941W), between 81 and 82 meters along a permanent transect.

  19. Kingman Reef Site 5P 4/3/2004 25-26M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 25 and 26 meters along a permanent transect.

  20. Kingman Reef Site 5P 4/3/2004 10-11M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 10 and 11 meters along a permanent transect.

  1. Kingman Reef Site 5P 4/3/2004 21-22M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 21 and 22 meters along a permanent transect.

  2. Kingman Reef Site 5P 4/3/2004 23-24M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 23 and 24 meters along a permanent transect.

  3. Kingman Reef Site 5P 4/3/2004 24-25M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 24 and 25 meters along a permanent transect.

  4. Kingman Reef Site 5P 4/3/2004 20-21M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 20 and 21 meters along a permanent transect.

  5. Kingman Reef Site 5P 4/3/2004 11-12M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 11 and 12 meters along a permanent transect.

  6. Kingman Reef Site 5P 4/3/2004 12-13M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 12 and 13 meters along a permanent transect.

  7. Kingman Reef Site 5P 4/3/2004 19-20M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 19 and 20 meters along a permanent transect.

  8. Kingman Reef Site 5P 4/3/2004 7-8M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 7 and 8 meters along a permanent transect.

  9. Kingman Reef Site 5P 4/3/2004 17-18M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 17 and 18 meters along a permanent transect.

  10. Kingman Reef Site 5P 4/3/2004 15-16M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 15 and 16 meters along a permanent transect.

  11. Kingman Reef Site 5P 4/3/2004 22-23M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 22 and 23 meters along a permanent transect.

  12. Kingman Reef Site 5P 4/3/2004 16-17M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 16 and 17 meters along a permanent transect.

  13. Kingman Reef Site 5P 4/3/2004 13-14M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 13 and 14 meters along a permanent transect.

  14. Kingman Reef Site 5P 4/3/2004 18-19M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 18 and 19 meters along a permanent transect.

  15. Kingman Reef Site 5P 4/3/2004 14-15M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Kingman Reef, site 5P (6 23.805N, 162 20.941W), between 14 and 15 meters along a permanent transect.

  16. Rose Atoll Site 5P 2/10/2004 7-6M

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Rose Atoll, site 5P (14 33.280 S, 168 09.878 W), between 7 and 8 meters along a permanent transect.

  17. Howland Island Site 5P 3/17/2000 31-32M

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Howland Island, site 5P 00 48.340 N, 176 37.272 W, between 31 and 32 meters along a permanent transect.

  18. Nuclear PI5P, Uhrf1, and the Road Not Taken

    Reynoird, Nicolas; Gozani, Or

    2014-01-01

    In this issue of Molecular Cell, Gelato et al (2014) identify the signaling molecule phosphatidylinositol-5-phosphate (PI5P) as an allosteric regulator that determines the mode of chromatin binding for the DNA methylation maintenance factor Uhrf1. This work links nuclear lipids to chromatin signaling in the maintenance of DNA methylation and epigenetic regulation.

  19. Nuclear PI5P, Uhrf1, and the road not taken.

    Reynoird, Nicolas; Gozani, Or

    2014-06-19

    In this issue of Molecular Cell, Gelato et al. (2014) identify the signaling molecule phosphatidylinositol 5-phosphate (PI5P) as an allosteric regulator that determines the mode of chromatin binding for the DNA methylation maintenance factor Uhrf1. This work links nuclear lipids to chromatin signaling in the maintenance of DNA methylation and epigenetic regulation. PMID:24950375

  20. Kingman Reef Site 5P 2/23/2001 5-6M

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Kingman Reef, site 5P 6 23.805N, 162 20.941W, between 5 and 6 meters along a permanent transect.

  1. Predatory Governance

    Dalida Kadyrzhanova

    2005-01-01

    This paper argues that imperfect corporate control is a determinant of market structure. We integrate a widely accepted version of the separation of ownership and control -- Jensen's (1986) 'empire-building' hypothesis -- into a dynamic oligopoly model. Our main observation is that, due to product market competition, shareholders face an endogenous opportunity cost of governance. We derive shareholders' optimal governance choices and show analytically that governance has a first-order effect ...

  2. Corporate Governance

    Zingales, Luigi

    1998-01-01

    This paper summarizes my own personal view of what corporate governance is about. I argue that it makes sense to discuss corporate governance only in an incomplete contract world. In this world, the notion of corporate governance is intrinsically related to the definition of the firm. In this respect, the shortcomings of the existing definitions of the firm are reviewed and the possible applications of the idea that the firm is a ‘nexus of specific investments’ introduced by Rajan and Zingale...

  3. Corporate Governance

    Luigi Zingales

    1997-01-01

    This essay summarizes my own personal view of what corporate governance is about. I" argue that it makes sense to discuss corporate governance only in an incomplete contract world. " In this world, the notion of corporate governance is intrinsically related to the definition of the" firm. In this respect, I review the shortcomings of the existing definitions of the firm and the" possible applications of the idea that the firm is a specific investments" introduced by" Rajan and Zingales (1997a...

  4. The Governance Structure, Mechanism and Strategy of Library Consortia%图书馆联盟治理的结构、机制及策略

    刘丽萍

    2015-01-01

    文章在探究图书馆联盟治理的涵义和主要特征的基础上,对图书馆联盟治理结构模型和管理机制进行了重点分析,从政府、行业协会、图书馆、社会以及科研角度出发,提出了改进和提升图书馆联盟治理水平的对策和建议,为促进图书馆联盟治理和提高协同水平,实现可持续发展目标提供理论依据.%On the basis of the meaning and key feature of library consortia governance this paper analyzes the governance structure model and management mechanism and proposes the countermeasures and suggestions to enhance level of library consortia governance in order to promote the library consortia governance and improve the cooperative level, achieve the goal of sustainable development providing theoretical foundation from the government, industry associations, library, social and scientiifc research.

  5. miR-204-5p suppresses cell proliferation by inhibiting IGFBP5 in papillary thyroid carcinoma

    Liu, Lianyong; Wang, Jingnan; Li, Xiangqi; Ma, Junhua; Shi, Chao; Zhu, Hongling; Xi, Qian; Zhang, Jichen; Zhao, Xuemei; Gu, Mingjun, E-mail: mjgugonglihos@yeah.net

    2015-02-20

    microRNAs (miRNAs) are frequently dysregulated in human malignancies. It was recently shown that miR-204-5p is downregulated in papillary thyroid carcinoma (PTC); however, the functional significance of this observation is not known. This study investigated the role of miR-204-5p in PTC. Overexpressing miR-204-5p suppressed PTC cell proliferation and induced cell cycle arrest and apoptosis. The results of a luciferase reporter assay showed that miR-204-5p can directly bind to the 3′ untranslated region (UTR) of insulin-like growth factor-binding protein 5 (IGFBP5) mRNA, and IGFBP5 overexpression partially reversed the growth-inhibitory effects of miR-204-5p. These results indicate that miR-204-5p acts as a tumor suppressor in PTC by regulating IGFBP5 expression and that miR-204-5p can potentially serve as an antitumorigenic agent in the treatment of PTC. - Highlights: • miR-204-5p expression is downregulated in PTC tissues and cell lines. • miR-204-5p suppresses proliferation and promotes apoptosis in PTC cells. • miR-204-5p suppresses IGFBP5 expression by direct binding to the 3′-UTR. • IGFBP5 overexpression reverses the effects of miR-204-5p.

  6. Competence, governance, and entrepreneurship

    Foss, Nicolai Juul; Mahnke, Volker

    This title illustrates modern economics. Because it informs strategic choices, it is relevant to business administration in general, and for strategic management in particular. Two dominant streams may be identified in the literature, namely the "competence" and "governance" perspectives on the f...... entrepreneurship to advance and stimulate economic strategy research....

  7. Corporate governance cycles during transition

    Mygind, Niels; Demina, Natalia; Gregoric, Aleksandra;

    2004-01-01

    -ing or exit stage. During transition the cycle reflects: privatization often with a high proportion of employee ownership like in Russia and in Slovenia; strong pressures for restructuring and owner-ship changes; limited possibility for external finance because of embryonic development of the fi......-nancial system. To provide simple hypothesis tests, we use Russian enterprise data for 1995-2003 and Slovenian data covering 1998-2003. In spite of differences in institutional development, con-cerning privatization and development of corporate governance institutions, we find that govern-ance cycles are broadly...... ownership on managers, external domestic and foreign owners. JEL-codes: G3, J5, P2, P3 - Keywords: corporate governance, life-cycle, privatization, ownership change, transition economies, Russia and Slovenia....

  8. Cdc42 and PI(4,5)P2-induced actin assembly in Xenopus egg extracts.

    Lebensohn, Andres M; Ma, Le; Ho, Hsin-Yi Henry; Kirschner, Marc W

    2006-01-01

    Xenopus egg cytoplasmic extracts have been used to study a variety of complex cellular processes. Given their amenability to biochemical manipulation and physiological balance of regulatory proteins, these extracts are an ideal system to dissect signal transduction pathways leading to actin assembly. We have developed methods to study Cdc42 and PI(4,5)P2-induced actin assembly in Xenopus egg extracts. In this chapter, we describe detailed procedures to prepare Xenopus egg extracts, Cdc42, and PI(4,5)P2 for use in actin assembly experiments. We also describe a fluorometric pyrene actin assay for quantitative kinetic analysis of actin polymerization and a microscopic rhodamine actin assay for quick measurement of actin rearrangements in extracts. Finally we provide a protocol for immunodepletion of proteins and discuss the use of immunodepletion and rescue experiments for functional analysis of components in the extracts. PMID:16472657

  9. Microstates of D1–D5(-P) black holes, as interacting D-branes

    In our previous study (Morita et al., 2014 [1]), we figured out that the thermodynamics of the near extremal black p-branes can be explained as the collective motions of gravitationally interacting elementary p-branes (the p-soup proposal). We test this proposal in the near-extremal D1–D5 and D1–D5-P black holes and show that their thermodynamics also can be explained in a similar fashion, i.e. via the collective motions of the interacting elementary D1-branes and D5-branes (and waves). It may imply that the microscopic origins of these intersecting black branes and the black p-brane are explained in the unified picture. We also argue the relation between the p-soup proposal and the conformal field theory calculations of the D1–D5(-P) black holes in superstring theory

  10. The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain

    Pietroni, Paola; Vasisht, Nishi; Cook, Jonathan P;

    2013-01-01

    model is that the bulk of ER-dislocated RTA is degraded by proteasomes. We show here that the proteasome has a more complex role in ricin intoxication than previously recognised, that the previously reported increase in sensitivity of mammalian cells to ricin in the presence of proteasome inhibitors......5p in the triage of substrates in which either activation (folding) or inactivation (degradation) pathways may be initiated....

  11. Corporate Governance

    Žilková, Alena

    2009-01-01

    Definition and basic theoretic information about Corporate Governance of big industry company Description and Analyse of corporate Management, the functions of Top Management Members, their role in relationship to owners / shareholders (describtion of used tools for internal control of government, investment and tools for financial analyses)

  12. Adaptation on a regional level. From national and supranational strategies to practical actions in the local and regional government and the economic life

    The presentation reviews various national strategies in the climate policies with emphasis on challenge approaches and greenhouse gas emissions. Measures in and implementations of the climatic handling and policies both regionally, nationally and supranationally are discussed (tk)

  13. MicroRNA miR-J1-5p as a potential biomarker for JC virus infection in the gastrointestinal tract.

    Alexander Link

    Full Text Available INTRODUCTION: JC virus (JCV, a human polyomavirus that causes progressive multifocal leukoencephalopathy (PML, has been linked to colorectal cancer (CRC. However, determination of JCV infection and its role in carcinogenesis has been challenging, highlighting the need for better diagnostic strategies for this virus. JCV-specific microRNAs (miRNAs were identified and shown to negatively regulate oncogenic JCV T-Ag. Herein, we determined the pattern of JCV miRNA expression in clinical specimens from healthy subjects and CRC patients. MATERIAL AND METHODS: JCV miRNA expression was validated in CRC cell lines transfected with the JCV T-Ag. Results were confirmed using CRC tissues that were expressed T-Ag. Expression of JCV-specific miR-J1-5p was measured in fresh stool samples from healthy volunteers, and samples from fecal occult blood test kits from healthy subject, and patients with colorectal neoplasms. RESULTS: JCV miR-J1-5p was detected in JCV-transfected, but not vector-transfected, CRC cells, and was stable between cell passages. MiR-J1-5p was present in all six JCV T-Ag+ CRC samples. Surprisingly, JCV miRNA was detectable in all normal tissues, but the expression was much lower in CRC tissues. Similarly, miR-J1-5p expression was present in all fecal samples, but expression was lower in CRCs compared to controls or adenoma patients. CONCLUSION: JC virus-specific miR-J1-5p miRNA is a potential biomarker for viral infection, and the lower expression in patients with colonic neoplasia highlights its biological role regulating oncogenic T-Ag expression in CRC. IMPACT: JCV-specific miRNA is a candidate for the development of a non-invasive screening test, as well as therapeutic intervention for JCV-associated diseases.

  14. Revealing the Anti-Tumor Effect of Artificial miRNA p-27-5p on Human Breast Carcinoma Cell Line T-47D

    Hsueh-Fen Juan

    2012-05-01

    Full Text Available microRNAs (miRNAs cause mRNA degradation or translation suppression of their target genes. Previous studies have found direct involvement of miRNAs in cancer initiation and progression. Artificial miRNAs, designed to target single or multiple genes of interest, provide a new therapeutic strategy for cancer. This study investigates the anti-tumor effect of a novel artificial miRNA, miR P-27-5p, on breast cancer. In this study, we reveal that miR P-27-5p downregulates the differential gene expressions associated with the protein modification process and regulation of cell cycle in T-47D cells. Introduction of this novel artificial miRNA, miR P-27-5p, into breast cell lines inhibits cell proliferation and induces the first “gap” phase (G1 cell cycle arrest in cancer cell lines but does not affect normal breast cells. We further show that miR P-27-5p targets the 3′-untranslated mRNA region (3′-UTR of cyclin-dependent kinase 4 (CDK4 and reduces both the mRNA and protein level of CDK4, which in turn, interferes with phosphorylation of the retinoblastoma protein (RB1. Overall, our data suggest that the effects of miR p-27-5p on cell proliferation and G1 cell cycle arrest are through the downregulation of CDK4 and the suppression of RB1 phosphorylation. This study opens avenues for future therapies targeting breast cancer.

  15. Renewing governance.

    Loos, Gregory P

    2003-01-01

    Globalization's profound influence on social and political institutions need not be negative. Critics of globalization have often referred to the "Impossible Trinity" because decision-making must 1. respect national sovereignty, 2. develop and implement firm regulation, and 3. allow capital markets to be as free as possible. To many, such goals are mutually exclusive because history conditions us to view policy-making and governance in traditional molds. Thus, transnational governance merely appears impossible because current forms of governance were not designed to provide it. The world needs new tools for governing, and its citizens must seize the opportunity to help develop them. The rise of a global society requires a greater level of generality and inclusion than is found in most policy bodies today. Politicians need to re-examine key assumptions about government. States must develop ways to discharge their regulatory responsibilities across borders and collaborate with neighboring jurisdictions, multilateral bodies, and business. Concepts such as multilateralism and tripartism show great promise. Governments must engage civil society in the spirit of shared responsibility and democratic decision-making. Such changes will result in a renewal of the state's purpose and better use of international resources and expertise in governance. PMID:17208717

  16. Government Accounting

    Ian Ball; Gary Pflugrath

    2012-01-01

    As the current sovereign debt crisis engulfing Europe broadens and threatens to bring down more governments and lead the world into another, potentially very serious, economic slowdown, minimal commentary and public debate has focused on a fundamental problem, and the need to address it. That problem is the deficient – and sometimes fraudulent – accounting practices employed by many governments around the world. A major shortcoming of many governments has been highlighted by the crisis â€...

  17. Successful Shared Governance Through Education.

    Brull, Stacey

    2015-01-01

    Shared governance is one way nurses can attain a healthy work environment. Having direct-care nurses involved in raising relevant clinical and operational issues and creating systematic approaches has been linked to greater levels of empowerment which is often transposed into shared governance. Nurse leaders at one hospital used a comprehensive educational strategy to implement shared governance in less than 2 years. An authoritative style of leadership and decision making does not meet the needs of today's complex health care environment; nor does it meet the needs of today's employees. The focus on a very deliberate and educational strategy for shared governance was successful in building the structures and processes needed to take a unit and division from traditional governance to shared governance in less than 2 years. PMID:26845819

  18. Organizational governance

    Foss, Nicolai Juul; Klein, Peter G.

    This chapter reviews and discusses rational-choice approaches to organizational governance. These approaches are found primarily in organizational economics (virtually no rational-choice organizational sociology exists), particularly in transaction cost economics, principal-agent theory, and the...

  19. Measuring Governance

    Charles P. Oman; Christiane Arndt

    2010-01-01

    The use of governance indicators, as applied to developing countries, has grown spectacularly in recent years. Following the maxim that you cannot manage what you cannot measure, international investors and official development aid agencies, together with academics and the media, have turned widely to using quantitative governance indicators for both analytical and decision-making purposes – with far-reaching consequences for developing countries…

  20. Governance matters

    Bloom, David E.; David Steven; Mark Weston

    1999-01-01

    In a cross-section of more than 150 countries, the authors provide new empirical evidence of a strong causal relationship from better governance to better development outcomes. They base their analysis on a new database containing more than 300 governance indicators compiled from a variety of sources. They provide a detailed description of each of these indicators and sources. Using an unobserved components methodology (described in the companion paper by the same authors,"Aggregating Governa...

  1. Inhibition of Saccharomyces cerevisiae Pdr5p by a natural compound extracted from Brazilian Red Propolis

    Cinzia Lotti

    2011-10-01

    Full Text Available Multidrug resistance of cancer cells and pathogenic microorganisms leading to the treatment failure of some forms of cancer or life-threatening bacterial or fungal infections is often caused by the overexpression of multidrug efflux pumps belonging to the ATP-binding cassette transporters superfamily. The multidrug resistance of fungal cells often involves the overexpression of efflux pumps belonging to the pleiotropic drug resistance (PDR family of ABC transporters. Possibly the best-studied fungal PDR transporter is the multidrug resistance transporter Pdr5p of Saccharomyces cerevisiae. Some research groups have been searching for new inhibitors of these efflux pumps in order to alleviate resistance. Natural products are a great source for the discovery of new compounds with biological activity. Propolis is a complex resinous material collected by honeybees from exudates and buds of certain plant sources and this material is thought to serve as a defense substance for bee hives. Propolis is widely used in traditional medicine and is reported to have a broad spectrum of pharmacological properties. Literature reported some biological functionalities of propolis, such as antibacterial, antiviral, fungicidal, anti-inflammatory and anti-carcinogenic activities. The chemical composition of propolis is qualitatively and quantitatively variable. Components isolated from methanolic extract of red Brazilian propolis (Alagoas, Northeast of Brazil are isoflavonoids (including pterocarpans, isoflavans, isoflavones, flavanones and polyprenylated benzophenones. In this work we demonstrated the effects of five different isolated compounds on the ATPase activity of Pdr5p. Out of all five substances tested, only BRP-1 was able to completely abolish the enzymatic activity while others worked as positive modulators of the enzyme activity. BRP-1also inhibited the efflux of Rhodamine 6G from yeast cells overexpressing Pdr5p. Taken together, these results

  2. Corporate Governance

    Dragoș-Mihail Daghie

    2011-05-01

    Full Text Available The purpose of this study is to analyze and understand the recently introduced form of managementof a company limited by shares. The Law no. 441/2006, which fundamentally amended Company Law,created this form of controlling the company, the corporate governance, but the legislation does not explicitlydefine what it wants to achieve through this instrument. This topic is recent in research as the theme ofgerman-roman commercial law systems (in French corporate governance system was introduced in 1966 andin Romania in 2006 but in terms of Anglo-Saxon law, the topic has been addressed years since 1776 (AdamSmith: The Wealth of Nations The concept of corporate governance would like, as a result, to establish somerules that companies must comply in order to achieve effective governance, transparent and beneficial forboth shareholders and for the minority. Corporate governance is a key element with an aim at improvingefficiency and economic growth in full accordance with the increase of investors’ confidence. Corporategovernance assumes a series of relationship between the company management, leadership, shareholders andthe other people concerned. Also corporate governance provides for that structure by means of which thecompany’s targets are set out and the means to achieve them and also the manner how to monitor such.

  3. Territorial Governance and Area Image

    Nicola Bellini

    2004-01-01

    The image of a region or a city is an emerging topic in most debates about economic development strategies at the local and national level. Local and national policies of innovation which form an essential part of modern policies of local development are less and less an expression of government and increasingly an exercise of governance. The concept that allows best to describe and understand the practical meaning and implications of governance is 'policy network'. The establishment, selecti...

  4. SeNtInel 5P validaTion by Comet HALO

    Fix, Andreas; Ehret, Gerhard; BOVENSMANN Heinrich; Gerbig, Christoph; K. Pfeilsticker; Zöger, Martin

    2015-01-01

    The goal of the proposed activity is the validation of the methane column of S5P using aircraft measurements. The airborne platform foreseen is the German research aircraft HALO. A dedicated HALO science mission that is focused on the measurement of methane (and carbon dioxide), dubbed CoMet, has been evaluated by the scientific steering committee of HALO and is now scheduled for the 1st half of 2017. In order to maximize gain, the team proposes to make use of the gathered data from this...

  5. MicroRNA-548a-5p promotes proliferation and inhibits apoptosis in hepatocellular carcinoma cells by targeting Tg737

    Zhao, Ge; Wang, Ting; Huang, Qi-Ke; Pu, Meng; Sun, Wei; Zhang, Zhuo-Chao; Ling, Rui; Tao, Kai-Shan

    2016-01-01

    AIM: To investigate whether Tg737 is regulated by microRNA-548a-5p (miR-548a-5p), and correlates with hepatocellular carcinoma (HCC) cell proliferation and apoptosis. METHODS: Assays of loss of function of Tg737 were performed by the colony formation assay, CCK assay and cell cycle assay in HCC cell lines. The interaction between miR-548a-5p and its downstream target, Tg737, was evaluated by a dual-luciferase reporter assay and quantitative real-time polymerase chain reaction. Tg737 was then up-regulated in HCC cells to evaluate its effect on miR-548a-5p regulation. HepG2 cells stably overexpressing miR-548a-5p or miR-control were also subcutaneously inoculated into nude mice to evaluate the effect of miR-548a-5p up-regulation on in vivo tumor growth. As the final step, the effect of miR-548a-5p on the apoptosis induced by cisplatin was evaluated by flow cytometry. RESULTS: Down-regulation of Tg737, which is a target gene of miR-548a-5p, accelerated HCC cell proliferation, and miR-548a-5p promoted HCC cell proliferation in vitro and in vivo. Like the down-regulation of Tg737, overexpression of miR-548a-5p in HCC cell lines promoted cell proliferation, increased colony forming ability and hampered cell apoptosis. In addition, miR-548a-5p overexpression increased HCC cell growth in vivo. MiR-548a-5p down-regulated Tg737 expression through direct contact with its 3’ untranslated region (UTR), and miR-548a-5p expression was negatively correlated with Tg737 levels in HCC specimens. Restoring Tg737 (without the 3’UTR) significantly hampered miR-548a-5p induced cell proliferation, and rescued the miR-548a-5p induced cell proliferation inhibition and apoptosis induced by cisplatin. CONCLUSION: MiR-548a-5p negatively regulates the tumor inhibitor gene Tg737 and promotes tumorigenesis in vitro and in vivo, indicating its potential as a novel therapeutic target for HCC.

  6. Crystal structure of an EAL domain in complex with reaction product 5'-pGpG.

    Julien Robert-Paganin

    Full Text Available FimX is a large multidomain protein containing an EAL domain and involved in twitching motility in Pseudomonas aeruginosa. We present here two crystallographic structures of the EAL domain of FimX (residues 438-686: one of the apo form and the other of a complex with 5'-pGpG, the reaction product of the hydrolysis of c-di-GMP. In both crystal forms, the EAL domains form a dimer delimiting a large cavity encompassing the catalytic pockets. The ligand is trapped in this cavity by its sugar phosphate moiety. We confirmed by NMR that the guanine bases are not involved in the interaction in solution. We solved here the first structure of an EAL domain bound to the reaction product 5'-pGpG. Though isolated FimX EAL domain has a very low catalytic activity, which would not be significant compared to other catalytic EAL domains, the structure with the product of the reaction can provides some hints in the mechanism of hydrolysis of the c-di-GMP by EAL domains.

  7. An Investigation into the Effectiveness of the RewardSystem in the Government Sector in the Sultanate ofOman and the Potential for Introducinga Total Reward Strategy

    Al Jarradi, Khalid

    2011-01-01

    The problem of the migration of talent from developed countries is not a new one, andessentially it is understood that the reward systems of the countries involved are at faultin not providing individuals with rewards that they value. In the Sultanate of Oman,such a brain drain is not yet a problem, but over the last few years there has been anincreasing departure of talented people from the Omani Government Sector, as theprivate sector has more to offer. Such a phenomenon is wasteful in resp...

  8. Brain enhancer activities at the gene-poor 5p14.1 autism-associated locus.

    Inoue, Yukiko U; Inoue, Takayoshi

    2016-01-01

    Due to the vast clinical and genetic heterogeneity, identification of causal genetic determinants for autism spectrum disorder (ASD) has proven to be complex. Whereas several dozen 'rare' genetic variants for ASD susceptibility have been identified, studies are still underpowered to analyse 'common' variants for their subtle effects. A recent application of genome-wide association studies (GWAS) to ASD indicated significant associations with the single nucleotide polymorphisms (SNPs) on chromosome 5p14.1, located in a non-coding region between cadherin10 (CDH10) and cadherin9 (CDH9). Here we apply an in vivo bacterial artificial chromosome (BAC) based enhancer-trapping strategy in mice to scan the gene desert for spatiotemporal cis-regulatory activities. Our results show that the ASD-associated interval harbors the cortical area, striatum, and cerebellum specific enhancers for a long non-coding RNA, moesin pseudogene1 antisense (MSNP1AS) during the brain developing stages. Mouse moesin protein levels are not affected by exogenously expressed human antisense RNAs in our transgenic brains, demonstrating the difficulty in modeling rather smaller effects of common variants. Our first in vivo evidence for the spatiotemporal transcription of MSNP1AS however provides a further support to connect this intergenic variant with the ASD susceptibility. PMID:27503586

  9. Down-regulation of miR-192-5p protects from oxidative stress-induced acute liver injury.

    Roy, Sanchari; Benz, Fabian; Alder, Jan; Bantel, Heike; Janssen, Joern; Vucur, Mihael; Gautheron, Jeremie; Schneider, Anne; Schüller, Florian; Loosen, Sven; Luedde, Mark; Koch, Alexander; Tacke, Frank; Luedde, Tom; Trautwein, Christian; Roderburg, Christoph

    2016-07-01

    miR-192-5p has gained increasing relevance in various diseases, however, its function in acute liver injury is currently unknown. We analysed miR-192-5p serum levels and hepatic miR-192-5p expression in mice after hepatic ischaemia and reperfusion (I/R) as well as in toxic liver injury. On a functional level, miRNA levels were analysed in the different hepatic cell-compartments and in the context of tumour necrosis factor (TNF)-dependent liver cell death. We detected increased serum levels of miR-192-5p after hepatic I/R- and carbon tetrachloride (CCl4)-induced liver injury. miR-192-5p levels correlated with the degree of liver damage and the presence of hepatic cell death detected by TUNEL stainings (terminal deoxynucleotidyltransferase-mediated dUTP biotin nick-end labelling stainings). Moreover, expression of miR-192-5p was increased in a hypoxia/reoxygenation (H/R) model of in vitro hepatocyte injury, supporting that the passive release of miR-192-5p represents a surrogate for hepatocyte death in liver injury. In critically ill patients, miR-192-5p levels were elevated selectively in patients with liver injury and closely correlated with the presence of hepatic injury. In contrast with up-regulated miR-192-5p in the serum, we detected a down-regulation of miR-192-5p in both injured mouse and human livers. Deregulation of miR-192-5p in livers was dependent on stimulation with TNF. Functional experiments confirmed a protective effect of down-regulation of miR-192-5p in hepatocytes, suggesting a role of miR-192-5p in limiting liver injury. Finally, we identified Zeb2, an important regulator of cell death, as a potential target gene mediating the function of miR-192-5p Our data suggest that miR-192-5p is involved in the regulation of liver cell death during acute liver injury and might represent a potent marker of hepatic injury. PMID:27129188

  10. Up-regulated miR-199a-5p in gastric cancer functions as an oncogene and targets klotho

    Recent studies have shown that miR-199a-5p plays opposite roles in cancer initiation and progression of different cancer types, acting as oncogene for some cancer types but as tumor suppressor gene for others. However, the role and molecular mechanism of miR-199a-5p in gastric cancer are largely unknown. In this study, miR-199a-5p expression level in gastric cancer was first analyzed by qPCRand then validated in 103 gastric cancer patients by in situ hybridization (ISH). Gastric cancer cell lines were transfected with miR-199a-5p inhibitor and mimic, and underwent in vitro transwell assays. Target genes (klotho) were identified using Luciferase reporter assay. Immunohistochemical staining was also used to investigate on how miR-199a-5p regulates the tumour-suppressive effects of klotho in gastric cancer. In our present study, we found that miR-199a-5p level was significantly increased in gastric cancer tissues compared to paired normal tissues. We observed that miR-199a-5p could promote migration and invasion of gastric cancer cells. In situ hybridization of miR-199a-5p also confirmed that higher miR-199a-5p expression level was associated with increased likelihood of lymph node metastasis and later TNM stage. Luciferase reporter assay and immunohistochemistry revealed that klotho might be the downstream target of miR-199a-5p. Our present study suggests that miR-199a-5p acts as an oncogene in gastric cancer and functions by targeting klotho

  11. Bogotá experience in government: device and educational strategies to expressions, scenarios and breaks on a proposal for citizen culture

    Gloria Clemencia VALENCIA GONZÁLEZ

    2012-05-01

    Full Text Available The Bogotá currently known, rebuilt from the ashes of 9 April got used for decades to live labors, fear and mistrust, but particularly in exclusion. With the arrival of Antanas Mockus to Mayor broke various paradigms: he and his cabinet not came from the traditional political caste, came from the Academy and claimed other relationships with citizenship. In addition, became the city learning space because their Government project drew on the political but evidenced in the pedagogical and found its deployment in the communicative. Six priorities proposed for government experience are articulated around one: civic culture. Culture that should be disseminated, learned and implementation from train in town, then so is generate sense of belonging, would facilitate urban coexistence and would lead to the respect of the common heritage and recognition of the rights and duties of citizens. In the Mayor Mockus’s «great classroom» citizenship would of apathy to the habitancia. Far pedagogy and communication, as not nominated devices, managed to go beyond the labelling and the indication and approached the civic culture to political socialization? This reflection article links to research «higher education and training citizen, case Bogotá» and consists of five sections.

  12. Submission to the Government of Canada, in the national interest : a Canadian oil and natural gas strategy for a North American energy market

    The Canadian Association of Petroleum Producers (CAPP) sees a need for more federal emphasis on six main principles regarding an energy strategy that will ensure that Canada's economy and citizens benefit from free access to North American markets. The development of energy resources must be done in a manner that meets North American demand for energy supplies, addresses high prices by increasing supply and enhances Canada's role as a reliable energy supplier. CAPP has proposed the following six main principles for an energy strategy: (1) development of market oriented policies, (2) ensure regulatory effectiveness, (3) promote greater industry competitiveness, (4) create more jobs for stronger communities, (5) foster the development of technological innovation, and (6) use energy wisely and efficiently. The key components of each principle were described in detail, along with their benefits to the Canadian economy

  13. Government Regulatory

    Becker, Katie

    Government regulation of food products, food processing, and food preparation is imperative in bringing an unadulterated, nonmisleading, and safe food product to market and is relevant to all areas of food science, including engineering, processing, chemistry, and microbiology. The liability associated with providing consumers with an adulterated or substandard product cannot only tarnish a company's name and reputation, but also impose substantial financial repercussions on the company and those individuals who play an active role in the violation. In order for a company to fully comply with the relevant food laws (both federal and state), an intimate knowledge of food science is required. Individuals knowledgeable in food science play an integral role not only in implementing and counseling food companies/processors to ensure compliance with government regulations, but these individuals are also necessary to the state and federal governments that make and enforce the relevant laws and regulators.

  14. Implementing e-Government in Bosnia and Herzegovina : Practices and Challenges for the State government

    Bajramovic, Kemal

    2011-01-01

    Context: Electronic Government (sometimes referred to as digital government, online government) is the use of information and communication technologies to: a) enable optimization and innovation of all government internal processes in the back-office and external processes by providing government services to customers through Internet and other electronic means; and b) facilitate achieving goals of all government policies and strategies. Objectives: In this study we are explaining e-Governmen...

  15. Foundations' Governance for Strategic Philanthropy

    Giacomo Boesso; Fabrizio Cerbioni; Andrea Menini; Antonio Parbonetti

    2012-01-01

    This paper examines whether effective governance plays a major role in driving foundations’ strategy when it comes to making the choice between reactive or proactive philanthropy models. More specifically, we investigate the relationships between philanthropic strategy (expressive, receptive, proactive and collaborative) and [a] board capital (competences and networks), [b] board processes (planning, control, evaluation, etc.), and [c] chairman power (entrenchment and tenure).

  16. Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression

    Kote-Jarai, Zsofia; Saunders, Edward J; Leongamornlert, Daniel A;

    2013-01-01

    Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the telomerase reverse transcriptase (TERT) gene that...

  17. Electric-dipole 5s - 5p Transitions in Promethiumlike Ions

    Vilkas, M J; Ishikawa, Y; Trabert, E

    2008-02-29

    The 5s-5p electric-dipole resonance transitions in highly ionized promethiumlike ions have been studied applying relativistic multi-reference Moeller-Plesset second-order perturbation theory. The transition wavelengths are determined to within 0.2 {angstrom} in the more highly charged ions, where the level degeneracies are small. For somewhat lighter ions a very large reference space was used in order to account for the many degeneracies. In order to calculate transition probabilities and lifetimes, correlation corrections have been added to the transition operator in the next order. The contributions from the higher orders of the theory, that is, frequency-dependent Breit correction, Lamb shift, and mass shifts, have been estimated. The results are used to re-assess spectroscopic data from beam-foil, electron beam ion trap, and tokamak observations.

  18. Holographic description of non-supersymmetric orbifolded D1-D5-P solutions

    Chakrabarty, Bidisha; Virmani, Amitabh

    2015-01-01

    Non-supersymmetric black hole microstates are of great interest in the context of the black hole information paradox. We identify the holographic description of the general class of non-supersymmetric orbifolded D1-D5-P supergravity solutions found by Jejjala, Madden, Ross and Titchener. This class includes both completely smooth solutions and solutions with conical defects, and in the near-decoupling limit these solutions describe degrees of freedom in the cap region. The CFT description involves a general class of states obtained by fractional spectral flow in both left-moving and right-moving sectors, generalizing previous work which studied special cases in this class. We compute the massless scalar emission spectrum and emission rates in both gravity and CFT and find perfect agreement, thereby providing strong evidence for our proposed identification. We also investigate the physics of ergoregion emission as pair creation for these orbifolded solutions. Our results represent the largest class of non-supe...

  19. Electronic Government

    Wimmer, Maria A.; Traunmüller, Roland; Grönlund, Åke;

    This book constitutes the refereed proceedings of the 4th International Conference on Electronic Government, EGOV 2005, held in Copenhagen, Denmark, in August 2005. The 30 revised papers presented were carefully reviewed and selected from numerous submissions, and assess the state-of-the-art in e...

  20. Mobilizing Government

    Wang, Cancan; Medaglia, Rony; Jensen, Tina Blegind

    2016-01-01

    The nature of inter-organizational collaboration between government and other stakeholders is rapidly changing with the introduction of open social media (OSM) platforms. Characterized by a high degree of informality as well as a blurred personal/professional nature, OSM can potentially introduce...

  1. Dawn of e-government

    Henriksen, Helle Zinner; Damsgaard, Jan

    2007-01-01

    Most countries have defined strategies for e-government. The objectives for implementing e-government are often defined but the means for fuelling the adoption and diffusion of e-government are typically less well clear in the policy statements. The present study assesses the impact of latest...... internally and externally. The e-Day initiative represents a drastic change in the former policy statements concerning IT adoption and diffusion in Danish government. The policy statements had previously been based on voluntary adoption focusing on visions and pedagogical intervention in governmental...

  2. hsa-miR-125a-5p Enhances Invasion Ability in Non-Small Lung Carcinoma Cell Lines

    Enhua WANG

    2009-09-01

    Full Text Available Background and objective MicroRNAs (miRNAs are short non-coding RNAs that posttranscriptionally regulate gene expression by partially binding complementary to target sites in mRNAs. Although some impaired miRNA regulations have been observed in many human cancers, the functions of miR-125a are still unclear. The aim of this study is to investigate the expression of hsa-miR-125a-5p in NSCLC cell lines and the relationship between hsa-miR-125a-5p and the invasion of lung cancer cells. Methods The expression of hsa-miR-125a-5p and the effectiveness for a given period time after being transfected sense hsa-miR-125a-5p 2’-O-methyl oligonucleotide, which were 24 h, 36 h, 48 h, 60 h and 72 h, were examined by realtime PCR. Meanwhile, we investigated the modification of invasive ability in A549 and NCI-H460 cells by transwell. Results Real-time PCR showed that hsa-miR-125a-5p was poorly-expressed in 6 lung cancer cell lines, especially in LH7, NCI-H460, SPC-A-1 and A549. The highest expression of hsa-miR-125a-5p occurred in the cells transfected with sense hsa-miR-125a-5p 2’-O-methyl oligonucleotide 36 h. Furthermore, the invasive abilities of A549 and NCI-H46O were enhanced by up-regulating hsa-miR-125a-5p. Conclusion hsa-miR-125a-5p was poorly-expressed in lung cancer cells and it could enhance lung cancer cell invasion by up-regulating hsa-miR-125a-5p.

  3. MiRNA-125a-5p inhibits glioblastoma cell proliferation and promotes cell differentiation by targeting TAZ

    Highlights: • Expression of miR-125a-5p is inversely correlated with that of TAZ in glioma cells. • MiR-125a-5p represses TAZ expression in glioma cells. • MiR-125a-5p directly targets the 3′ UTR of TAZ mRNA and promotes its degradation. • MiR-125a-5p represses CTGF and survivin via TAZ, and inhibits glioma cell growth. • MiR-125a-5p inhibits the stem cell features of HFU-251 MG cells. - Abstract: Glioblastoma (GBM) is the most lethal brain tumor due to the resistance to conventional therapies, such as radiotherapy and chemotherapy. TAZ, an important mediator of the Hippo pathway, was found to be up-regulated in diverse cancers, including in GBM, and plays important roles in tumor initiation and progression. However, little is known about the regulation of TAZ expression in tumors. In this study, we found that miR-125a-5p is an important regulator of TAZ in glioma cells by directly targeting the TAZ 3′ UTR. MiR-125a-5p levels are inversely correlated with that of TAZ in normal astrocytes and a panel of glioma cell lines. MiR-125a-5p represses the expression of TAZ target genes, including CTGF and survivin, and inhibits cell proliferation and induces the differentiation of GBM cells; whereas over-expression of TAZ rescues the effects of miR-125a-5p. This study revealed a mechanism for TAZ deregulation in glioma cells, and also demonstrated a tumor suppressor role of miR-125a-5p in glioblastoma cells

  4. MiRNA-125a-5p inhibits glioblastoma cell proliferation and promotes cell differentiation by targeting TAZ

    Yuan, Jian; Xiao, Gelei [Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008 (China); The Institute of Skull Base Surgery & Neuro-oncology at Hunan, Changsha, Hunan 410008 (China); Peng, Gang [Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008 (China); Liu, Dingyang [Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008 (China); The Institute of Skull Base Surgery & Neuro-oncology at Hunan, Changsha, Hunan 410008 (China); Wang, Zeyou [Cancer Research Institute, Central South University, Changsha, Hunan 410008 (China); Liao, Yiwei; Liu, Qing [Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008 (China); The Institute of Skull Base Surgery & Neuro-oncology at Hunan, Changsha, Hunan 410008 (China); Wu, Minghua [The Institute of Skull Base Surgery & Neuro-oncology at Hunan, Changsha, Hunan 410008 (China); Cancer Research Institute, Central South University, Changsha, Hunan 410008 (China); Yuan, Xianrui, E-mail: xry69@163.com [Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008 (China); The Institute of Skull Base Surgery & Neuro-oncology at Hunan, Changsha, Hunan 410008 (China)

    2015-02-06

    Highlights: • Expression of miR-125a-5p is inversely correlated with that of TAZ in glioma cells. • MiR-125a-5p represses TAZ expression in glioma cells. • MiR-125a-5p directly targets the 3′ UTR of TAZ mRNA and promotes its degradation. • MiR-125a-5p represses CTGF and survivin via TAZ, and inhibits glioma cell growth. • MiR-125a-5p inhibits the stem cell features of HFU-251 MG cells. - Abstract: Glioblastoma (GBM) is the most lethal brain tumor due to the resistance to conventional therapies, such as radiotherapy and chemotherapy. TAZ, an important mediator of the Hippo pathway, was found to be up-regulated in diverse cancers, including in GBM, and plays important roles in tumor initiation and progression. However, little is known about the regulation of TAZ expression in tumors. In this study, we found that miR-125a-5p is an important regulator of TAZ in glioma cells by directly targeting the TAZ 3′ UTR. MiR-125a-5p levels are inversely correlated with that of TAZ in normal astrocytes and a panel of glioma cell lines. MiR-125a-5p represses the expression of TAZ target genes, including CTGF and survivin, and inhibits cell proliferation and induces the differentiation of GBM cells; whereas over-expression of TAZ rescues the effects of miR-125a-5p. This study revealed a mechanism for TAZ deregulation in glioma cells, and also demonstrated a tumor suppressor role of miR-125a-5p in glioblastoma cells.

  5. Evaluating the ability of artificial neural network and PCA-M5P models in predicting leachate COD load in landfills.

    Azadi, Sama; Amiri, Hamid; Rakhshandehroo, G Reza

    2016-09-01

    Waste burial in uncontrolled landfills can cause serious environmental damages and unpleasant consequences. Leachates produced in landfills have the potential to contaminate soil and groundwater resources. Leachate management is one of the major issues with respect to landfills environmental impacts. Improper design of landfills can lead to leachate spread in the environment, and hence, engineered landfills are required to have leachate monitoring programs. The high cost of such programs may be greatly reduced and cost efficiency of the program may be optimized if one can predict leachate contamination level and foresee management and treatment strategies. The aim of this study is to develop two expert systems consisting of Artificial Neural Network (ANN) and Principal Component Analysis-M5P (PCA-M5P) models to predict Chemical Oxygen Demand (COD) load in leachates produced in lab-scale landfills. Measured data from three landfill lysimeters, including rainfall depth, number of days after waste deposition, thickness of top and bottom Compacted Clay Liners (CCLs), and thickness of top cover over the lysimeter, were utilized to develop, train, validate, and test the expert systems and predict the leachate COD load. Statistical analysis of the prediction results showed that both models possess good prediction ability with a slight superiority for ANN over PCA-M5P. Based on test datasets, the mean absolute percentage error for ANN and PCA-M5P models were 4% and 12%, respectively, and the correlation coefficient for both models was greater than 0.98. Developed models may be used as a rough estimate for leachate COD load prediction in primary landfill designs, where the effect of a top and/or bottom liner is disputed. PMID:27264459

  6. Small government or big government?

    MATEO SPAHO

    2015-03-01

    Full Text Available Since the beginning of the twentieth century, economists and philosophers were polarizedon their positions beyond the role that the government should have in the economy. On one hand John Maynard Keynes represented, within the optics of market economy, a position where the state should intervene in the economy to maintain the aggregate demand and the employment in the country, without hesitation in creating budget deficits and public debt expansion. This approach happens especially in the moments when the domestic economy and global economic trends show a weak growth or a recession. This means a heavy interference inthe economy, with higher income but with high expenditure to GDP too. On the other side, Liberals and Neoliberalsled by Friedrich Hayek advocated a withdrawal of the government from economic activity not just in moments of economic growth but also during the crisis, believing that the market has self-regulating mechanisms within itself. The government, as a result will have a smaller dimension with lower income and also low expenditures compared to the GDP of the country. We took the South-Eastern Europe countries distinguishing those with a "Big Government" or countries with "Small Government". There are analyzed the economic performances during the global crisis (2007-2014. In which countries the public debt grew less? Which country managed to attract more investments and which were the countries that preserved the purchasing power of their consumers? We shall see if during the economic crisis in Eastern Europe the Great Government or the Liberal and "Small" one has been the most successful the model.

  7. MicroRNA-219-5p Inhibits Morphine-Induced Apoptosis by Targeting Key Cell Cycle Regulator WEE1.

    Lou, Wei; Zhang, Xingwang; Hu, Xiao-Ying; Hu, Ai-Rong

    2016-01-01

    BACKGROUND To identify the effects of microRNA (miR)-219-5p on morphine-induced apoptosis by targeting WEE1. MATERIAL AND METHODS Forty Balb/C mice (Toll-like receptor 9, TLR9 knockout) were randomly allocated to the experimental and control groups (20 in each group). The baseline miR-219-5p expression was detected using quantitative real-time PCR (qRT-PCR). After morphine was injected at 6 h on the 2nd and 6th days, experimental and control groups received miR-219-5p mimics or miRNA-negative control (NC), respectively, compound injection. Tissues and cells were later obtained from subjects in each group separately after mice were killed. TUNEL assay was used to investigate apoptosis in both groups. RAW264.7 cells were treated with miR-219-5p mimics and controls, respectively. After 24 h, 10 μM of morphine was added at 24 h. Cell apoptosis was assessed by flow cytometer. The WEE1 and Phospho-cdc2 (Tyr15) expressions were examined by Western blotting. RESULTS MiR-219-5p expression in the experimental group was significantly lower than that in the control group (P<0.05). Mice injected with miR-219-5p mimic experienced an evident increase in apoptosis rate compared with the control group (P<0.05). The miR-219-5p NC group and the morphine group both presented an elevated apoptosis rate compared with the blank control group (both, P<0.05). The apoptosis rate in the miR-219-5p mimic group was 10.06%, remarkably lower than in the miR-219-5p NC group and blank control group (both P<0.05). WEE1 and Tyr15 protein expressions in the miR-219-5p NC group and morphine group were obviously stronger than those in the blank control group (all P<0.05). In the miR-219-5p mimic group, WEE1 and Tyr15 protein expressions were significantly lower compared with those in the miR-219-5p NC group and morphine group (all P<0.05). CONCLUSIONS Morphine significantly downregulated the expression of miRNA-219-5p, which targets WEE1 to suppress Tyr15 expressions and activate Cdc2, thus inhibiting

  8. 中国政务微博发展对策研究--基于2014年的数据分析%Study on the Strategies of Chinese Government Microblogging Development Based on the Data of 2014

    陈朋亲; 杨天保

    2016-01-01

    2014 is the node time of Chinese government microblogging development.Generally,it surpassed the previous years in scale,structure,the degree of government participation and the effects of information communication,etc.,and basically achieved the goal of“soft landing”,which laid the cornerstone for national governance system.However,there are still problems of out-dated concept of governance,unbalanced development among regions and departments,less communication between the government and people,and so on.To this end,the strategy is,firstly,to enhance a cognitive level,based on a new pattern of Internet Politics both concentrated on “nation”and “citizens”,and clarify the relationship between the subject and the object,rebuilding governance structure;secondly, it’s necessary to“de-bureaucratize”the traditional governance mode and highlight the role of Internet in modern political development ;thirdly,we have to integrate political resources,enhance the intensity expert governance;fourthly,the “State - society”relations should be properly handled, optimizing the control of the ecological,vigorously develop social management of new elements;fifthly,we must upgrade rural hardware systems,ease the development gap between urban and rural areas;finally,we need to cure the disease of modern political apathy of our citizens and build the“government -citizen”interactive relationship of mutual trust.%2014年是中国政务微博发展的节点。总体而论,其规模、格局、政府参与度和信息传播效果等,皆超越往年,基本实现“软着陆”,为融入国家治理体系奠定了基石。但是,治理理念相对滞后,区域、部门及城乡间的发展不平衡,官民“互粉率”偏低等问题依旧存在。针对存在的问题,提出了中国政务微博的发展对策:一要提升认知水平,基于“国家公民”双本位的互联网政治新格局,明确主客体关系,重建治理结构;二

  9. Local Government Internal Audit Compliance

    Greg Jones

    2015-09-01

    Full Text Available Local government councils (LGC rely on a number of funding sources including state and federal governments as well as their community constituents to enable them to provide a range of public services. Given the constraints on these funding sources councils need to have in place a range of strategies and policies capable of providing good governance and must appropriately discharge their financial accountabilities. To assist LGC with meeting their governance and accountability obligations they often seek guidance from their key stakeholders. For example, in the Australian State of New South Wales (NSW, the Office of Local Government has developed a set of guidelines, the Internal Audit Guidelines. In 2010 the NSW Office of Local Government issued revised guidelines emphasising that an internal audit committee is an essential component of good governance. In addition, the guidelines explained that to improve the governance and accountability of the councils, these committees should be composed of a majority of independent members. To maintain committee independence the guidelines indicated that the Mayor should not be a member of the committee. However these are only guidelines, not legislated requirements and as such compliance with the guidelines, before they were revised, has been demonstrated to be quite low (Jones & Bowrey 2013. This study, based on a review of NSW Local Government Councils’ 2012/2013 reports, including Annual Reportsrelation to internal audit committees, to determine if the guidelines are effective in improving local government council governance.

  10. 面向电子政务的 MongoDB 与 MySQL 混合存储策略%Hybrid Storage Strategy with MongoDB and MySQL for E-government

    吴秀君

    2014-01-01

    针对传统电子政务平台所采用的关系型数据库在存储非结构化数据时的缺陷,利用MongoDB存储海量非结构化数据的优势,提出MongoDB与MySQL混合存储的策略。 MongoDB负责存储图片、视频等非结构化数据,MySQL负责存储用户注册信息、工资表等结构化数据。二者协同提供政务数据的云存储服务和查询操作,从而降低MySQL数据库服务器的负载,节约MySQL的存储空间,增强电子政务后台数据库的扩展性。实验结果表明,该混合策略能大大提高电子政务平台的查询效率。%For the defects of relational database used in traditional e-government platform when storing unstructured data , the ad-vantages of MongoDB in storing mass unstructured data are used to put forward a hybrid storage strategy with MongoDB and MySQL.MongoDB is responsible for storing unstructured data such as pictures , video.MySQL is responsible for storing structured data such as user registration information , payroll.Both of them work together to provide data cloud storage services and query operations of e-government data , thereby reducing the load on the database server of MySQL , saving the storage space and enhancing the scalability of e-government back-end database .Comparative tests show that the hybrid strategy can greatly im-prove the query efficiency of e-government platform .

  11. Research on the relation between the knowledge governance mechanism and the strategy orientation%知识治理机制和战略导向的关系研究

    陈俊; 王影

    2013-01-01

    在认同知识治理的本质是对知识活动所涉主体行为的协调这一基础上,归纳和分析官僚控制、社区自治、市场调节三类典型的知识治理机制的总体特征;同时,基于顾客导向、创新导向的战略导向分类,以不同战略导向匹配相异的知识治理机制组合权重为切入点,提出环境变动、知识活动障碍是企业战略导向、知识治理机制、知识活动之间演进关系的内在机理;最后,总结分析两条典型的演进路径,并指出顾客知识、治理经验的累积是演进关系螺旋上升的源动力。%On the basis of the fact that the essence of knowledge governance is to coordinate the behavior of knowledge sub -jects related to the knowledge activity , we analyze the general feature of hierarchy control、 communication autonomy、 mar-ket transaction by means of theory induction.At the same time , in this paper , the variation of environment and the barrier of knowledge activity are the inner cause of the evolutionary relation between strategy orientation 、 knowledge governance mechanism and knowledge activity if the different strategy , which includes customer orientation and innovation orientation , match the different combined weight of the governance mechanisms.Finally, two typical evolutionary paths are generated in this paper.And the original dynamic leading to the upward spiral of evolutionary relation lies in the accumulation of custom -er knowledge and governance experience.

  12. The government draft of the Combined Heat and Power Generation Act 2016. Exit strategy or prospects for the future?; Der Regierungsentwurf zum KWKG 2016. Ausstiegsszenario oder Zukunftsperspektive?

    Ecke, Julius [enervis energy advisors GmbH, Berlin (Germany)

    2015-11-15

    The combined heat and power (CHP) is in addition to renewable energy and energy efficiency a cornerstone for the transformation of the energy sector towards greater climate and environmental friendliness. Due to the situation in the energy markets currently plants operated with natural gas have come under pressure. Against the background of the critical economic situation of many gas-based cogeneration plants, it is therefore necessary, with a new combined heat and power law (CHP) to provide planning security for the plant operator. Meanwhile, there is a government draft of the Combined Heat and Power Generation Act in 2016, which includes far-reaching changes for the CHP. This article summarizes the most important changes. [German] Die Kraft-Waerme-Kopplung (KWK) ist neben den erneuerbaren Energien und der Energieeffizienz einer der Eckpfeiler fuer die Transformation des Energiesektors hin zu mehr Klima- und Umweltfreundlichkeit. Aufgrund der Situation auf den Energiemaerkten sind aber gerade mit Erdgas betriebene Anlagen unter Druck geraten. Vor dem Hintergrund der wirtschaftlich kritischen Situation vieler gasbasierter KWK-Anlagen gilt es daher, durch ein neues Kraft-Waerme-Kopplungs-Gesetz (KWKG) Planungssicherheit fuer die Anlagenbetreiber zu schaffen. Inzwischen liegt ein Regierungsentwurf zum KWKG 2016 vor, der weitreichende Aenderungen fuer die KWK beinhaltet. Dieser Artikel fasst die wichtigsten Aenderungen zusammen.

  13. Government Construction Safety Supervision and Strategies Game%政府建筑安全监管博弈分析及策略选择

    陈宝春

    2011-01-01

    建筑安全事故的频繁发生已严重制约着和谐社会的构建和建筑业的健康发展.基于博弈论原理,从政府监管机构、承包商、监理三个安全责任主体利益考虑,构建了监管机构与承包商、监管机构与监理的博弈模型,分析了建筑安全事故产生的本质原因,并提出了安全监管的应对措施,以降低建筑安全事故的发生.%The frequent occurrence of accidents in censtruction has seriously restricted the construction of harmonious society and the healthy development of the construction industry.Based on the game theory, from the government regulatory agencies, contractors, supervision of the security responsibility of the three main interests, the paper builds regulatory agencies and contractors, regulatory agencies and supervision of the game model to analyze the construction safety accidents of nature, and puts forward security control measures in order to lower construction safety accidents.

  14. Strategi Pemberdayaan Perusahaan Waralaba Lokal Menuju Waralaba Global: Studi Kasus Good Corporate Governance oleh Eksekutif Puncak di J.Co, Es Teller 77, dan Pecel Lele Lela

    Lelo Yosep Laurentius

    2015-08-01

    Full Text Available This research is mainly intended for reviewing and strengthening leadership, corporate governance good practices and management philosophy in the concepts, systems, and human resources (HR of the company. A new progressive corporate leader should be able to quickly identify the strengths and weaknesses of his/her business, to increase the first and to reduce the pressures or to liquidate the later. Finally, he/she must be able to encourage his/her subordinates to achieve easily identified and highly attractive goals. The target is to build the 21st-century company where all employees realize that they can make it different and that they will warmly welcome the managerial motivation. Thus, the chief executive officer assumes the responsibility for constructive managerial skills. Research used qualitative approach to disclose GCG in local franchise companies. Case study was done purposively with chief executive officer of the company. Data were gathered by observation and literature study. Analysis was conducted by data reduction, data presentation, and conclusion.

  15. Molecular Recognition of PTS-1 Cargo Proteins by Pex5p: Implications for Protein Mistargeting in Primary Hyperoxaluria

    Noel Mesa-Torres

    2015-02-01

    Full Text Available Peroxisomal biogenesis and function critically depends on the import of cytosolic proteins carrying a PTS1 sequence into this organelle upon interaction with the peroxin Pex5p. Recent structural studies have provided important insights into the molecular recognition of cargo proteins by Pex5p. Peroxisomal import is a key feature in the pathogenesis of primary hyperoxaluria type 1 (PH1, where alanine:glyoxylate aminotransferase (AGT undergoes mitochondrial mistargeting in about a third of patients. Here, we study the molecular recognition of PTS1 cargo proteins by Pex5p using oligopeptides and AGT variants bearing different natural PTS1 sequences, and employing an array of biophysical, computational and cell biology techniques. Changes in affinity for Pex5p (spanning over 3–4 orders of magnitude reflect different thermodynamic signatures, but overall bury similar amounts of molecular surface. Structure/energetic analyses provide information on the contribution of ancillary regions and the conformational changes induced in Pex5p and the PTS1 cargo upon complex formation. Pex5p stability in vitro is enhanced upon cargo binding according to their binding affinities. Moreover, we provide evidence that the rational modulation of the AGT: Pex5p binding affinity might be useful tools to investigate mistargeting and misfolding in PH1 by pulling the folding equilibria towards the native and peroxisomal import competent state.

  16. Plural Governance

    Mols, Niels Peter; Hansen, Jesper Rosenberg; Villadsen, Anders Ryom

    We suggest that both making and buying the same product or service has several effects on market performance. A model is developed and tested by use of 170 answers gathered from the Danish municipalities. The results support the hypotheses that both making and buying: (1) moderates the negative r...... on how the plurality is measured. The results indicate that internal production may facilitate effective governance of the relationships with suppliers. Implications for research on firm boundaries and for practice are also discussed....

  17. CORPORATE GOVERNANCE

    Dan Alexandru SITARU

    2009-01-01

    The work is aimed to examine the issues “corporate governance” involves, with the goal set to clarify the meanings of such notion, and to provide an overall image of the positive effects arising implementing the corporate governance principles. The first section includes a series of definitions for the purpose of explaining and outlining the concept of “corporate governance”, subsequently giving a definition that appears adequate to us, from the legal standpoint pre eminently. The second sect...

  18. CORPORATE GOVERNANCE

    Dan Alexandru SITARU

    2009-10-01

    Full Text Available The work is aimed to examine the issues “corporate governance” involves, with the goal set to clarify the meanings of such notion, and to provide an overall image of the positive effects arising implementing the corporate governance principles. The first section includes a series of definitions for the purpose of explaining and outlining the concept of “corporate governance”, subsequently giving a definition that appears adequate to us, from the legal standpoint pre eminently. The second section has for purpose to state the corporate governance Principles, and briefly examine the same. Its purpose also includes concretely illustrating the efficient operation methods for a “corporation”, as well as the main dilemmas, and the existing solutions for the same within the internal structure of a joint stock company to adopt, and subject itself to, such principles. Finally, the last section of the work underlines the corporate governance importance, and states the goals to be attained for purposes of securing effective, balanced, and not in the last place profitable management.

  19. MiR-508-5p Inhibits the Progression of Glioma by Targeting Glycoprotein Non-metastatic Melanoma B.

    Bao, Gang; Wang, Ning; Li, Ruichun; Xu, Gaofeng; Liu, Peijun; He, Baixiang

    2016-07-01

    Glioma is a severe and highly lethal brain cancer, a malignancy largely stemming from growing in a relatively restrained area of the brain. Hence, the understanding of the molecular regulation of the growth of glioma is critical for improving its treatment. MicroRNA has become a hotspot in research on diseases, especially in the initiation and progression of different types of cancer. However, the molecular function and mechanisms of miR-508-5p in gliomagenesis are still unclear. The aim of this study was to investigate miR-508-5p expression in glioma and determine its effects on proliferation. miR-508-5p expression levels, both in glioma cell lines and in tissue, were significantly lower than in a normal human astrocyte cell line or adjacent tissues. Cell growth was analyzed using a MTT assay and over-expression of miR-508-5p was found to decrease glioma cell growth. Moreover, a bioinformatic analysis was performed, showing that glycoprotein non-metastatic melanoma B (GPNMB) was a direct target for miR-508-5p in glioma cells. Furthermore, in vivo treatment with miR-508-5p reduced GPNMB protein levels in the tumor. Additionally, overexpression of GPNMB without 3'-UTR partially reversed the cell growth arrest induced by miR-508-5p over-expression in glioma cells. In conclusion, these results indicate that increased expression of miR-508-5p might be related to glioma progression, indicating a potential role of miR-508-5p for clinical therapy. PMID:27003587

  20. Circulating miR-122-5p as a potential novel biomarker for diagnosis of acute myocardial infarction

    Yao, Xin-Liang; Lu, Xue-Li; Yan, Cheng-Yun; Wan, Qi-Lin; Cheng, Guan-Chang; Li, Yan-Ming

    2015-01-01

    Background: MicroRNAs (miRNAs) play key roles in cardiac development, and the expression of miRNAs is altered in the diseased heart. The aim of this study was to explore the value of circulating microRNA-122-5p (miR-122-5p) as a potential biomarker for acute myocardial infarction (AMI). Methods: Plasma samples from 50 patients with AMI and 39 healthy adults (non-AMI controls) were collected. The abundance of circulating miR-122-5p was measured using quantitative real-time PCR (qRT-PCR). The c...

  1. Isotope shifts of the 4s2 1S0 -> 4s5p 1P1 transition and hyperfine splitting of the 4s5p 1P1 state in calcium

    Mortensen, A.; Lindballe, J. J. T.; Jensen, I. S.; Staanum, P.; Voigt, D.; Drewsen, M.

    2004-01-01

    Using a technique based on production of ion Coulomb crystals, the isotope shifts of the 4s2 1S0 -> 4s5p 1P1 transition for all naturally occurring isotopes of calcium as well as the hyperfine splitting of the 4s5p 1P1 state in Ca-43 have been measured. The field shift and specific mass shift coefficients as well as the hyperfine structure constants for Ca-43 have been derived from the data.

  2. Urban Decline and Failed Reconversion Process: the Role of "Path Dependence" and Governance Theories in Local Actors' Strategies. The Case of Langreo (Spain

    JOSÉ PRADA TRIGO

    2012-01-01

    Full Text Available During the sixties and the seventies, most of the European cities suffered an economic crisis and an urban restructuring process, particularly the traditional industrial cities and regions. These places suffered a deep slow-down in their growth and a decline process. In Spain, Asturias is one of the most affected regions by the crisis, and the Asturian cities specialized in the mining activity and the traditional industry (Avilés, Gijón, Langreo and Mieres entered a process of decline in the sixties that in some cases continues today. In Langreo, the strong reindustrialisation policy developed by the local actors has not contributed to modify the image of “industrial city”. Today, the important presence of the industry in Langreo is paradoxical, when services are the economic driving force of the city and its principal source of employment. The lack of urban planning has given rise to a deteriorated urban landscape, where people do not wish to live today because of the proximity of industrial activities and the troubles that in some ways they cause. This paper analyses the unsuccessful process of urban and economic renovation as well as the current situation of Langreo. In order to do this, it uses a methodology that combines statistical information with interviews with local actors involved in the city’s development. The main results are: (i A critical analysis of the situation of Langreo and its future perspectives, (ii A summary of the contrast between the different models proposed by the local actors for the city and (iii Some conclusions about the importance of executing an urban organization to fit the economic and employment parameters with the physical and territorial conditions of the city. Some issues like the different intensity in the implication of local agents, or the mechanism that govern the alliances between them also stand out.

  3. A multichannel harpoon model for reactive quenching of Xe 5p56p by Cl2

    A harpoon reaction model employing multiple crossings based on the formalism of Bauer et al and Gislason and Sachs is developed to explain the large cross sections (σ ∼400 A2) measured for the reaction Xe 5p56p + Cl2. The model calculates the Landau-Zener transition probability for each intermediate ionic crossing with the covalent surface. The transition matrix elements are represented as a product of the electronic interaction (modeled by the empirical result of Olson et al) and a Frank-Condon factor for the Cl2 → Cl2- transition. The model predicts near unit probability for a transition to the ionic surface for impact parameters less than 20 Bohr. Once transfer occurs, the pair is captured by dissociation of Cl2- to form XeCl. The large temperature dependence observed qualitatively in the experiments is explained by the increased cross section for vibrationally excited Cl2. A simple model for orbiting collisions is used to estimate the effect of termolecular collisions

  4. Holographic description of non-supersymmetric orbifolded D1-D5-P solutions

    Chakrabarty, Bidisha; Turton, David; Virmani, Amitabh

    2015-11-01

    Non-supersymmetric black hole microstates are of great interest in the context of the black hole information paradox. We identify the holographic description of the general class of non-supersymmetric orbifolded D1-D5-P supergravity solutions found by Jejjala, Madden, Ross and Titchener. This class includes both completely smooth solutions and solutions with conical defects, and in the near-decoupling limit these solutions describe degrees of freedom in the cap region. The CFT description involves a general class of states obtained by fractional spectral flow in both left-moving and right-moving sectors, generalizing previous work which studied special cases in this class. We compute the massless scalar emission spectrum and emission rates in both gravity and CFT and find perfect agreement, thereby providing strong evidence for our proposed identification. We also investigate the physics of ergoregion emission as pair creation for these orbifolded solutions. Our results represent the largest class of non-supersymmetric black hole microstate geometries with identified CFT duals presently known.

  5. Governance processes and change within organizational participants of multi-sectoral community health care alliances: the mediating role of vision, mission, strategy agreement and perceived alliance value.

    Hearld, Larry R; Alexander, Jeffrey A

    2014-03-01

    Multi-sectoral community health care alliances are organizations that bring together individuals and organizations from different industry sectors to work collaboratively on improving the health and health care in local communities. Long-term success and sustainability of alliances are dependent on their ability to galvanize participants to take action within their 'home' organizations and institutionalize the vision, goals, and programs within participating organizations and the broader community. The purpose of this study was to investigate two mechanisms by which alliance leadership and management processes may promote such changes within organizations participating in alliances. The findings of the study suggest that, despite modest levels of change undertaken by participating organizations, more positive perceptions of alliance leadership, decision making, and conflict management were associated with a greater likelihood of participating organizations making changes as a result of their participation in the alliance, in part by promoting greater vision, mission, and strategy agreement and higher levels of perceived value. Leadership processes had a stronger relationship with change within participating organizations than decision-making style and conflict management processes. Open-ended responses by participants indicated that participating organizations most often incorporated new measures or goals into their existing portfolio of strategic plans and activities in response to alliance participation. PMID:24415003

  6. Quantitative analysis of photoquadrats acquired at Johnston Atoll permanent transect site 5P on July 2, 2000

    US Fish and Wildlife Service, Department of the Interior — This spreadsheet summarizes the number of corals photographed along a permanent transect line at Underwater Site 5P at Johnston Atoll on 722000.

  7. Regulating Government

    Probst, Katherine; Davies, J. Clarence

    2001-01-01

    Federal, state, and local governments are major polluters of the environment. They account for more than 7% of SO2 air pollution emissions and more than 5% of all NO2 air emissions in the United States. Public entities are more likely than private ones to be in violation of the Clean Water Act, and they account for two-thirds of all major facilities in significant noncompliance with the act. Department of Energy nuclear sites are the worst hazardous waste problems in the nation. A lack of ade...

  8. Governing Warfare

    Harste, Gorm

      It would seem as though warfare has gotten out of control, not only in Iraq and Afghanistan, but also in Central Africa. The paper outlines the strategic history of politically controlled warfare since the early Enlightenment. The argument is that control is implausible. The idea of control has...... risks of lacking unity and displays the organisational trap to the fatal political myth of controlled warfare: Does it come from the military organisation system itself, from political ideologies of goal-rational governance, or from the chameleonic logic of wars?  ...

  9. Expression and function of microRNA-188-5p in activated rheumatoid arthritis synovial fibroblasts.

    Ruedel, Anke; Dietrich, Peter; Schubert, Thomas; Hofmeister, Simone; Hellerbrand, Claus; Bosserhoff, Anja Katrin

    2015-01-01

    Activated synovial fibroblasts in rheumatoid arthritis (RASF) play a critical role in the pathology of rheumatoid arthritis (RA). Recent studies suggested that deregulation of microRNAs (miRs) affects the development and progression of RA. Therefore, we aimed to identify de-regulated miRs in RASF and to identify target genes that may contribute to the aggressive phenotype of RASF. Quantitative real-time PCR revealed a marked downregulation of miR-188-5p in synovial tissue samples of RA patients as well as in RASF. Exposure to the cytokine interleukine-1β lead to a further downregulation of miR-188-5p expression levels compared to control cells. Re-expression of miR-188-5p in RASF by transient transfection significantly inhibited cell migration. However, miR-188-5p re-expression had no effects on glycosaminoglycan degradation or expression of repellent factors, which have been previously shown to affect the invasive behavior of RASF. In search for target genes of miR-188-5p in RASF we performed gene expression profiling in RASF and found a strong regulatory effect of miR-188-5p on the hyaluronan binding protein KIAA1199 as well as collagens COL1A1 and COL12A1, which was confirmed by qRT-PCR. In silico analysis revealed that KIAA1199 carries a 3'UTR binding site for miR-188-5p. COL1A1 and COL12A1 showed no binding site in the mRNA region, suggesting an indirect regulation of these two genes by miR-188-5p. In summary, our study showed that miR-188-5p is down-regulated in RA in vitro and in vivo, most likely triggered by an inflammatory environment. MiR-188-5p expression is correlated to the activation state of RASF and inhibits migration of these cells. Furthermore, miR-188-5p is directly and indirectly regulating the expression of genes, which may play a role in extracellular matrix formation and destruction in RA. Herewith, this study identified potential novel therapeutic targets to inhibit the development and progression of RA. PMID:26261542

  10. A combined M5P tree and hazard-based duration model for predicting urban freeway traffic accident durations.

    Lin, Lei; Wang, Qian; Sadek, Adel W

    2016-06-01

    The duration of freeway traffic accidents duration is an important factor, which affects traffic congestion, environmental pollution, and secondary accidents. Among previous studies, the M5P algorithm has been shown to be an effective tool for predicting incident duration. M5P builds a tree-based model, like the traditional classification and regression tree (CART) method, but with multiple linear regression models as its leaves. The problem with M5P for accident duration prediction, however, is that whereas linear regression assumes that the conditional distribution of accident durations is normally distributed, the distribution for a "time-to-an-event" is almost certainly nonsymmetrical. A hazard-based duration model (HBDM) is a better choice for this kind of a "time-to-event" modeling scenario, and given this, HBDMs have been previously applied to analyze and predict traffic accidents duration. Previous research, however, has not yet applied HBDMs for accident duration prediction, in association with clustering or classification of the dataset to minimize data heterogeneity. The current paper proposes a novel approach for accident duration prediction, which improves on the original M5P tree algorithm through the construction of a M5P-HBDM model, in which the leaves of the M5P tree model are HBDMs instead of linear regression models. Such a model offers the advantage of minimizing data heterogeneity through dataset classification, and avoids the need for the incorrect assumption of normality for traffic accident durations. The proposed model was then tested on two freeway accident datasets. For each dataset, the first 500 records were used to train the following three models: (1) an M5P tree; (2) a HBDM; and (3) the proposed M5P-HBDM, and the remainder of data were used for testing. The results show that the proposed M5P-HBDM managed to identify more significant and meaningful variables than either M5P or HBDMs. Moreover, the M5P-HBDM had the lowest overall mean

  11. miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway

    Zhang, Yu [Department of Neurology, The First Affiliated School of Harbin Medical University, Harbin 150001 (China); Wei, Guangkuan [Department of Neurology, Heilongjiang Provincial Hospital, Harbin 150036 (China); Di, Zhiyong [Department of Laboratory, Heilongjiang Provincial Hospital, Harbin 150036 (China); Zhao, Qingjie, E-mail: zhaoqingjie2013@163.com [Department of Neurology, The First Affiliated School of Harbin Medical University, Harbin 150001 (China)

    2014-09-26

    Graphical abstract: - Highlights: • Alcohol upregulates miR-339-5p expression. • miR-339-5p inhibits the NF-kB pathway. • miR-339-5p interacts with and blocks activity of IKK-beat and IKK-epsilon. • miR-339-5p modulates IL-1β, IL-6 and TNF-α. - Abstract: Alcohol-induced neuroinflammation is mediated by the innate immunesystem. Pro-inflammatory responses to alcohol are modulated by miRNAs. The miRNA miR-339-5p has previously been found to be upregulated in alcohol-induced neuroinflammation. However, little has been elucidated on the regulatory functions of this miRNA in alcohol-induced neuroinflammation. We investigated the function of miR-339-5p in alcohol exposed brain tissue and isolated microglial cells using ex vivo and in vitro techniques. Our results show that alcohol induces transcription of miR 339-5p, IL-6, IL-1β and TNF-α in mouse brain tissue and isolated microglial cells by activating NF-κB. Alcohol activation of NF-κB allows for nuclear translocation of the NF-κB subunit p65 and expression of pro-inflammatory mediators. miR-339-5p inhibited expression of these pro-inflammatory factors through the NF-κB pathway by abolishing IKK-β and IKK-ε activity.

  12. Suppression of microRNA-125a-5p upregulates the TAZ-EGFR signaling pathway and promotes retinoblastoma proliferation.

    Zhang, Yiting; Xue, Chunyan; Zhu, Xiaomin; Zhu, Xinyue; Xian, Hongyu; Huang, Zhenping

    2016-08-01

    Retinoblastoma is the most common intraocular malignancy that occurs during childhood; however, the mechanism underlying retinoblastoma proliferation and progression remains unclear. MicroRNAs (miRNAs) play an important role in the regulation of a myriad of biological processes in various types of cancer. In this study, we performed microarray analysis followed by qRT-PCR using four classes of retinoblastoma tissues with increasing cTNM classification stages to identify crucial miRNAs whose expression was correlated with retinoblastoma progression. miR-125a-5p was downregulated, and its expression levels were inversely correlated with cell proliferation in retinoblastoma compared with adjacent non-tumor retinal tissues. The overexpression of miR-125a-5p significantly suppressed cell proliferation and tumor formation in retinoblastoma. We further identified the transcriptional co-activator with PDZ binding motif (TAZ) as a direct target of miR-125a-5p. Importantly, TAZ levels were inversely correlated with miRNA-125a-5p expression, and TAZ promoted retinoblastoma cell proliferation. Moreover, the overexpression of miR-125a-5p led to a decrease in TAZ expression and downstream EGFR signaling pathway activation both in vitro and vivo. Finally, TAZ overexpression in retinoblastoma cells overexpressing miR-125a-5p restored retinoblastoma cell proliferation and EGFR pathway activation. Taken together, our data demonstrated that miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma. Thus, the miR-125a-5p/TAZ/EGFR axis may be a potential therapeutic target for retinoblastoma. PMID:27094723

  13. miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway

    Graphical abstract: - Highlights: • Alcohol upregulates miR-339-5p expression. • miR-339-5p inhibits the NF-kB pathway. • miR-339-5p interacts with and blocks activity of IKK-beat and IKK-epsilon. • miR-339-5p modulates IL-1β, IL-6 and TNF-α. - Abstract: Alcohol-induced neuroinflammation is mediated by the innate immunesystem. Pro-inflammatory responses to alcohol are modulated by miRNAs. The miRNA miR-339-5p has previously been found to be upregulated in alcohol-induced neuroinflammation. However, little has been elucidated on the regulatory functions of this miRNA in alcohol-induced neuroinflammation. We investigated the function of miR-339-5p in alcohol exposed brain tissue and isolated microglial cells using ex vivo and in vitro techniques. Our results show that alcohol induces transcription of miR 339-5p, IL-6, IL-1β and TNF-α in mouse brain tissue and isolated microglial cells by activating NF-κB. Alcohol activation of NF-κB allows for nuclear translocation of the NF-κB subunit p65 and expression of pro-inflammatory mediators. miR-339-5p inhibited expression of these pro-inflammatory factors through the NF-κB pathway by abolishing IKK-β and IKK-ε activity

  14. miR‑30a‑5p in the tumorigenesis of renal cell carcinoma: A tumor suppressive microRNA.

    Li, Yifan; Li, Yuchi; Chen, Duqun; Jin, Lu; Su, Zhengming; Liu, Jiaju; Duan, Hongfang; Li, Xiaoqing; Qi, Zhengyu; Shi, Min; Ni, Liangchao; Yang, Shangqi; Gui, Yaoting; Mao, Xiangming; Chen, Yun; Lai, Yongqing

    2016-05-01

    Renal cell carcinoma (RCC) is the most common type of malignant tumor of the adult kidney and has a poor prognosis. MicroRNAs (miRs) are important in a wide range of biological and pathological processes, including cell differentiation, migration, growth, proliferation, apoptosis and metabolism. The present study aimed to determine the role exerted by miR‑30a‑5p in the tumorigenesis of RCC. The expression levels of miR‑30a‑5p in RCC tissues and RCC‑derived cells were demonstrated to be significantly downregulated by real‑time quantitative polymerase chain reaction (RT‑qPCR). Wound scratch assay, cell proliferation assay and flow cytometric analysis revealed that the abilities of migration and proliferation of the RCC‑derived cells were suppressed, whereas cell apoptosis was promoted, when miR‑30a‑5p was overexpressed in these cells. N‑acetylgalactosaminyltransferase 7 (GALNT7) was predicted to be one target gene of miR‑30a‑5p by bioinformatics analysis. Luciferase reporter assay, RT‑qPCR and western blotting were performed to confirm that GALNT7 is the direct conserved target of miR‑30a‑5p. These results suggested that miR‑30a‑5p has a tumor‑suppressive role in the tumorigenesis of RCC. PMID:27035333

  15. Governing Engineering

    Buch, Anders

    2011-01-01

    Abstract: Most people agree that our world faces daunting problems and, correctly or not, technological solutions are seen as an integral part of an overall solution. But what exactly are the problems and how does the engineering ‘mind set’ frame these problems? This chapter sets out to unravel dominant perspectives in challenge perception in engineering in the US and Denmark. Challenge perception and response strategies are closely linked through discursive practices. Challenge perceptions w...

  16. Urban Governance of Disease

    Julie E. Fischer

    2012-04-01

    Full Text Available Rapid population growth, urbanization, and the growing challenges faced by the urban poor require redefining the paradigm for public health interventions in the 21st century, creating new approaches that take urban determinants of health into consideration. The widening disparity between the urban poor and the urban rich further exacerbates health inequities. Existing tools for global governance of urban health risks fall short, particularly in the lack of formal mechanisms to strengthen collaboration and communication among national and municipal agencies and between their local and international non-governmental partners. There is also a clear disconnect between governance strategies crafted at the international level and implementation on the ground. The challenge is to find common ground for global goods and municipal needs, and to craft innovative and dynamic policy solutions that can benefit some of the poorest citizens of the global urban network.

  17. Internet Governance

    Pedro Veiga

    2010-01-01

    Full Text Available It has now become quite obvious that the Internet has brought significant changes to our society and a break on how we lived before its emergence. It is still too early to assess the impact on society of the new services at our disposal, such as the capacity to communicate faster and cheaper on a global scale, access information and, perhaps more importantly, to produce and disseminate information in a way that is accessible to all.It is clear that the advent of the Information Society implies changes in our society that constitute a point of no return. However, contrary to what happened when we entered the Industrial Age about three centuries ago, when the changing process was slow and led by older individuals, these days the entrance into the Information Society is taking place rapidly and the decisive players are younger people. The global nature of the Internet, the possibility of producing and distributing any type of content in digital form at almost zero cost, as well as the vast number of people who use the web, have highlighted the need for new forms of intervention in a sector where there are many types of players. It is in this context that the problem of Internet Governance becomes a very current issue, inasmuch as one feels the need to guarantee a diversity of rights and duties, which may appear difficult to reconcile.This paper presents a brief overview of the main players and initiatives which, in the field of Internet Governance, have tried to contribute to turning this network into a factor for social development and democraticity on a global scale.

  18. MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption.

    Darcq, E; Warnault, V; Phamluong, K; Besserer, G M; Liu, F; Ron, D

    2015-10-01

    MicroRNAs (miRNAs) induce messenger RNA (mRNA) degradation and repress mRNA translation. Several miRNAs control the expression of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex (PFC). The BDNF signaling pathway is activated by moderate intake of alcohol to prevent escalation to excessive drinking. Here, we present data to suggest that the transition from moderate to uncontrolled alcohol intake occurs, in part, upon a breakdown of this endogenous protective pathway via a miRNA-dependent mechanism. Specifically, a mouse paradigm that mimics binge alcohol drinking in humans produced a robust reduction in BDNF mRNA levels in the medial PFC (mPFC), which was associated with increased expression of several miRNAs including miR-30a-5p. We show that miR-30a-5p binds the 3' untranslated region of BDNF, and that overexpression of miR-30a-5p in the mPFC decreased BDNF expression. Importantly, overexpression of miR-30a-5p in the mPFC produced an escalation of alcohol intake and a preference over water. Conversely, inhibition of miR-30a-5p in the mPFC using a Locked Nucleic Acid sequence that targets miR-30a-5p restored BDNF levels and decreased excessive alcohol intake. Together, our results indicate that miR-30a-5p plays a key role in the transition from moderate to excessive alcohol intake. PMID:25330738

  19. miR-493-5p attenuates the invasiveness and tumorigenicity in human breast cancer by targeting FUT4.

    Zhao, Lifen; Feng, Xiaobin; Song, Xiaobo; Zhou, Huimin; Zhao, Yongfu; Cheng, Lei; Jia, Li

    2016-08-01

    Breast cancer is a leading cause of cancer-related mortality among women. Altered fucosylation was found to be closely associated with tumorigenesis and metastasis of breast cancer. MicroRNAs (miRNAs) are important regulators of cell proliferation and metastasis, and aberrant miRNA expression has been observed in breast cancer. The present study aimed to evaluate the level of fucosyltransferase IV (FUT4) and miR-493-5p in breast cancer and investigate their relationship. In the present study, we demonstrated the differential expressional profiles of FUT4 and miR‑493-5p in 29 clinical breast cancer tissues, matched adjacent tissue samples and two breast carcinoma cell lines (MCF-7 and MDA-MB-231). Briefly, altered expression levels of FUT4 modified the invasive activities and tumorigenicity of the MCF-7 and MDA-MB-231 cells. Further study demonstrated that miR-493-5p plays a role as a suppressor in breast cancer cell invasion and tumorigenicity. Moreover, the expression levels of miR-493-5p were inversely proportional to those of FUT4 both at the mRNA and protein levels. Luciferase reporter assays confirmed that miR‑493-5p bound to the 3'-untranslated (3'-UTR) region of FUT4, and inhibited the expression of FUT4 in breast cancer cells. Taken together, our data suggest that FUT4 may have a potential role in the treatment of breast cancer, as well as miR-493-5p is a novel regulator of invasiveness and tumorigenicity of breast cancer cells through targeting FUT4. The miR-493-5p/FUT4 pathway has therapeutic potential in breast cancer. PMID:27375041

  20. BARRIERS TO GOVERNMENT CLOUD ADOPTION

    Tweneboah-Koduah, Samuel; Tsetse, Anthony; Endicott-Popovsky, Barbara

    2014-01-01

    Besides the benefits are there possible challenges government agencies are likely to encounter should they decide to adopt cloud computing? What strategies should be deployed to overcome the inhibitors of cloud computing? These are but few questions this paper aims to investigate. Studies have...... shown that, cloud computing has become a strategic direction for many government agencies and is already being deployed in many critical areas of the government's cyber infrastructure. The benefits and the challenges of cloud adoption have heightened interest of academic research in recent times. We are...... greater problems from government information management. This study is based on unstructured interviews from selected government agencies in Ghana. The study is grounded on the theory of technology, organization and environment (TOE) framework. Major inhibiting factors identified include lack of basic...

  1. Homeostatic regulation of the PI(4,5)P2-Ca(2+) signaling system at ER-PM junctions.

    Chang, Chi-Lun; Liou, Jen

    2016-08-01

    The phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-Ca(2+) signaling system is important for cell activation in response to various extracellular stimuli. This signaling system is initiated by receptor-induced hydrolysis of PI(4,5)P2 in the plasma membrane (PM) to generate the soluble second messenger inositol 1,4,5-trisphosphate (IP3). IP3 subsequently triggers the release of Ca(2+) from the endoplasmic reticulum (ER) store to the cytosol to activate Ca(2+)-mediated responses, such as secretion and proliferation. The consumed PM PI(4,5)P2 and ER Ca(2+) must be quickly restored to sustain signaling responses, and to maintain the homeostasis of PI(4,5)P2 and Ca(2+). Since phosphatidylinositol (PI), the precursor lipid for PM PI(4,5)P2, is synthesized in the ER membrane, and a Ca(2+) influx across the PM is required to refill the ER Ca(2+) store, efficient communications between the ER and the PM are critical for the homeostatic regulation of the PI(4,5)P2-Ca(2+) signaling system. This review describes the major findings that established the framework of the PI(4,5)P2-Ca(2+) signaling system, and recent discoveries on feedback control mechanisms at ER-PM junctions that sustain the PI(4,5)P2-Ca(2+) signaling system. Particular emphasis is placed on the characterization of ER-PM junctions where efficient communications between the ER and the PM occur, and the activation mechanisms of proteins that dynamically localize to ER-PM junctions to provide the feedback control during PI(4,5)P2-Ca(2+) signaling, including the ER Ca(2+) sensor STIM1, the extended synaptotagmin E-Syt1, and the PI transfer protein Nir2. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon. PMID:26924250

  2. Shareholder Voting and Corporate Governance

    David Yermack

    2010-01-01

    This article reviews recent research into corporate voting and elections. Regulatory reforms have given shareholders more voting power in the election of directors and in executive compensation issues. Shareholders use voting as a channel of communication with boards of directors, and protest voting can lead to significant changes in corporate governance and strategy. Some investors have embraced innovative empty voting strategies for decoupling voting rights from cash flow rights, enabling t...

  3. Industrial Strategy:The Role of Government in Building Industrial Competitiveness Generative Capacity%产业战略:政府在构建产业竞争力生成能力中的作用分析

    张慧毅

    2014-01-01

    通过对发达国家在重点产业选择上的经验借鉴,指出中国的产业发展战略必须从以“有利于交换”为核心的制度观转向“有利于生产和创新”的制度观,从“低技术-低附加值-低工资”的产业发展观转变为“高技术-高附加值-高工资”的产业发展观。政府可以不管企业,但不能不管产业。政府可从间接打造产业环境方面入手,构建有利于ICGC提升的产业战略支持环境。%From the experience of the developed countries ’ choice of key industry , this paper points out:Chi-na’ s industrial development strategy must be changed from “the system facilitating the exchange” to “the system facilitating production and innovation”, and industrial development opinion should be changed from “low technolo-gy, low added value and low wage” to “high technology , high added value and high wage”.The government needn ’ t supervise enterprise , but it must supervise the industries .The government should start from indirect crea-ting the industry environment , building conducive industries strategic supporting environment to promote industrial competitiveness generative capacity ( ICGC) .

  4. Differential expression of microRNA501-5p affects the aggressiveness of clear cell renal carcinoma

    Alessandra Mangolini

    2014-01-01

    Full Text Available Renal cell carcinoma is a common neoplasia of the adult kidney that accounts for about 3% of adult malignancies. Clear cell renal carcinoma is the most frequent subtype of kidney cancer and 20–40% of patients develop metastases. The absence of appropriate biomarkers complicates diagnosis and prognosis of this disease. In this regard, small noncoding RNAs (microRNAs, which are mutated in several neoplastic diseases including kidney carcinoma, may be optimal candidates as biomarkers for diagnosis and prognosis of this kind of cancer. Here we show that patients with clear cell kidney carcinoma that express low levels of miR501-5p exhibited a good prognosis compared with patients with unchanged or high levels of this microRNA. Consistently, in kidney carcinoma cells the downregulation of miR501-5p induced an increased caspase-3 activity, p53 expression as well as decreased mTOR activation, leading to stimulation of the apoptotic pathway. Conversely, miR501-5p upregulation enhanced the activity of mTOR and promoted both cell proliferation and survival. These biological processes occurred through p53 inactivation by proteasome degradation in a mechanism involving MDM2-mediated p53 ubiquitination. Our results support a role for miR501-5p in balancing apoptosis and cell survival in clear cell renal carcinoma. In particular, the downregulation of microRNA501-5p promotes a good prognosis, while its upregulation contributes to a poor prognosis, in particular, if associated with p53 and MDM2 overexpression and mTOR activation. Thus, the expression of miR501-5p is a possible biomarker for the prognosis of clear cell renal carcinoma.

  5. IT governance a pocket guide

    Calder, Alan

    2007-01-01

    This new downloadable pocket guide in the Practical IT Governance series, is designed to provide the reader with a basic understanding of how an organization's Information Technology supports and enables the achievement of its strategies and objectives.

  6. Engineering governance: introducing a governance meta framework.

    Brand, N; Beens, B.; Vuuregge, E.; Batenburg, R.

    2011-01-01

    There is a need for a framework that depicts strategic choices within an organisation with regard to potential governance structures. The governance meta framework provides the necessary structure in the current developments of governance. Performance as well as conformance are embedded in this framework and provide the balance for all governance domains. (aut.ref.)

  7. A Structural Equation Model (SEM of Governing Factors Influencing the Implementation of T-Government

    Sameer Alshetewi

    2015-11-01

    Full Text Available Governments around the world have invested significant sums of money on Information and Communication Technology (ICT to improve the efficiency and effectiveness of services been provided to their citizens. However, they have not achieved the desired results because of the lack of interoperability between different government entities. Therefore, many governments have started shifting away from the original concept of e-Government towards a much more transformational approach that encompasses the entire relationship between different government departments and users of public services, which can be termed as transformational government (t- Government. In this paper, a model is proposed for governing factors that impact the implementation of t-Government such as strategy, leadership, stakeholders, citizen centricity and funding in the context of Saudi Arabia. Five constructs are hypothesised to be related to the implementation of t-Government. To clarify the relationships among these constructs, a structural equation model (SEM is utilised to examine the model fit with the five hypotheses. The results show that there are positive and significant relationships among the constructs such as the relationships between strategy and t-Government; the relationships between stakeholders and t-Government; the relationships between leadership and t-Government. This study also showed an insignificant relationship between citizens’ centricity and t-Government and also an insignificant relationship between funding and t-Government. document is a “live” template and already defines the components of your paper [title, text, heads, etc.] in its style sheet.

  8. The Politics of Governance Architectures

    Borrás, Susana; Radaelli, Claudio M.

    2011-01-01

    combinations of old and new organizational structures within the international organization in question. The Lisbon Strategy is the most high-profile initiative of the European Union for economic governance of the last decade. Yet it is also one of the most neglected subjects of EU studies, probably because......Governance architectures are strategic and long-term institutional arrangements of international organizations exhibiting three features; namely, they address strategic and long-term problems in a holistic manner, they set substantive output-oriented goals, and they are implemented through...... not being identified as an object of study on its own right. We define the Lisbon Strategy as a case of governance architecture, raising questions about its creation, evolution and impact at the national level. We tackle these questions by drawing on institutional theories about emergence and change...

  9. Building Blocks of an E-Government: A Framework

    Sharma, Sushil K.; Jatinder N. Gupta

    2003-01-01

    The movement toward electronic government (e-government) is rapidly advancing as nations exploit new electronic means of communication such as the Internet. The e-government transformation process can be and often is seriously hindered when initiatives are disjointed and uncoordinated by an overall strategy. Although many countries are creating e-government services, there is no documentation of an e-government framework to guide the process. Guidelines for implementation of e-government are ...

  10. 政府会计改革:战略次序、框架设计与冲突协调%Government Accounting Reform: Strategy Sequence, Framework Design and Conflict Harmonization

    路军伟

    2011-01-01

    Government accounting reform is a long and gradual process, in order to push this reform process successfully; we should establish a gradual strategy sequence: from control-orientation, management-orientation to report-orientation, according to objective%政府会计改革是一个长期和渐进的过程,为顺利推进我国政府会计改革进程,应根据国际政府会计改革的客观规律、我国的现实环境以及现行预算会计的弊端,确立“控制取向→管理取向→报告取向”的渐进式政府会计改革的战略次序安排;以包含政府财务会计和政府预算会计在内的双轨制政府会计体系为执行这一战略次序安排的支撑框架;以技术协调为核心,以组织协调为突破,循序渐进地推进我国政府会计改革。

  11. Arsenic-induced anti-angiogenesis via miR-425-5p-regulated CCM3.

    Gao, Yanfang; Yin, Yuzhu; Xing, Xiumei; Zhao, Zhiqiang; Lu, Yao; Sun, Yi; Zhuang, Zhixiong; Wang, Min; Ji, Weidong; He, Yun

    2016-07-01

    Human exposure to drinking water contaminated with arsenic is a serious global health concern and it predisposes people to cardiovascular diseases, such as hypertension, atherosclerosis, and microvascular diseases. Although accumulating evidence supports a role for angiogenesis responses to arsenic in the pathogenesis of the cardiovascular disease, the detailed molecular mechanism is not well understood. We aimed to determine the role and mechanism of microRNA (miRNA) in arsenic-induced angiogenesis. In our present study, sodium arsenite (NaAsO2) inhibited angiogenesis by decreasing cells proliferation, migration and tube formation in HUVECs. After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3). Furthermore, we showed that NaAsO2 up-regulated CCM3 expression in vitro and in vivo. In addition, we demonstrated that inhibition of Notch and activation of VEGF/p38 signaling were involved in miR-425-5p blocking NaAsO2-induced anti-angiogenesis. PMID:27132035

  12. Phase sensitive parametric interactions in a $Ga_{0.5}In_{0.5}P$ photonic crystal waveguide

    Willinger, Amnon; De Rossi, Alfredo; Eisenstein, Gadi

    2016-01-01

    We report phase sensitive amplification in a 1.5mm long, $Ga_{0.5}In_{0.5}P$ dispersion engineered photonic crystal waveguide which has a flattened dispersion profile. A signal degenerate configuration with pulsed pumps whose total peak power is only 0.5W yields a phase sensitive extinction ratio of 10dB.

  13. Quantitative Analyses of Force-Induced Amyloid Formation in Candida albicans Als5p: Activation by Standard Laboratory Procedures.

    Cho X J Chan

    Full Text Available Candida albicans adhesins have amyloid-forming sequences. In Als5p, these amyloid sequences cluster cell surface adhesins to create high avidity surface adhesion nanodomains. Such nanodomains form after force is applied to the cell surface by atomic force microscopy or laminar flow. Here we report centrifuging and resuspending S. cerevisiae cells expressing Als5p led to 1.7-fold increase in initial rate of adhesion to ligand coated beads. Furthermore, mechanical stress from vortex-mixing of Als5p cells or C. albicans cells also induced additional formation of amyloid nanodomains and consequent activation of adhesion. Vortex-mixing for 60 seconds increased the initial rate of adhesion 1.6-fold. The effects of vortex-mixing were replicated in heat-killed cells as well. Activation was accompanied by increases in thioflavin T cell surface fluorescence measured by flow cytometry or by confocal microscopy. There was no adhesion activation in cells expressing amyloid-impaired Als5pV326N or in cells incubated with inhibitory concentrations of anti-amyloid dyes. Together these results demonstrated the activation of cell surface amyloid nanodomains in yeast expressing Als adhesins, and further delineate the forces that can activate adhesion in vivo. Consequently there is quantitative support for the hypothesis that amyloid forming adhesins act as both force sensors and effectors.

  14. Elevated expression of circulating miR876-5p is a specific response to severe EV71 infections.

    Wang, Robert Y L; Weng, Kuo-Feng; Huang, Yhu-Chering; Chen, Chih-Jung

    2016-01-01

    Human enterovirus 71 (EV71) is a major causative agent of hand, foot, and, mouth disease, accounting for more than 65% of recent outbreaks. Following enteroviral infection, the host responses are crucial indicators for the development of a diagnosis regarding the clinical severity of EV71 infections. In this study, we implemented NanoString nCounter technology to characterize the responses of serum microRNA (miRNA) profiles to various EV71 infection diseases. Upon EV71 infection, 44 miRNAs were observed in patients with EV71 infections, with at least a 2-fold elevation and 133 miRNAs with a 2-fold reduction compared with the same miRNAs in healthy controls. Further detailed work with miR876-5p, a 9.5-fold change of upregulated miR-876-5p expression was observed in cases with severe EV71 symptoms, revealed that in vitro and in vivo knockdown of miR876-5p reduced viral RNA in cultured cells, and attenuated the severity of symptoms in EV71-infected mice. Altogether, we demonstrated that the elevated expression of circulating miR876-5p is a specific response to severe EV71 infections. PMID:27052555

  15. HTR1A a novel type 1 diabetes susceptibility gene on chromosome 5p13-q13

    Asad, Samina; Nikamo, Pernilla; Gyllenberg, Alexandra; Bennet, Hedvig; Hansson, Ola; Wierup, Nils; Carlsson, Annelie; Forsander, Gun; Ivarsson, Sten-Anders; Larsson, Helena; Lernmark, Åke; Lindblad, Bengt; Ludvigsson, Johnny; Marcus, Claude; Rønningen, Kjersti S; Nerup, Jørn; Pociot, Flemming; Luthman, Holger; Fex, Malin; Kockum, Ingrid

    2012-01-01

    We have previously performed a genome-wide linkage study in Scandinavian Type 1 diabetes (T1D) families. In the Swedish families, we detected suggestive linkage (LOD≤2.2) to the chromosome 5p13-q13 region. The aim of our study was to investigate the linked region in search for possible T1D...

  16. Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor-Positive, Lower Grade Breast Cancer

    Milne, Roger L; Goode, Ellen L; García-Closas, Montserrat;

    2011-01-01

    BACKGROUND: The single-nucleotide polymorphism (SNP) 5p12-rs10941679 has been found to be associated with risk of breast cancer, particularly estrogen receptor (ER)-positive disease. We aimed to further explore this association overall, and by tumor histopathology, in the Breast Cancer Associatio...

  17. Synthetic Steroid Hormones Regulated Cell Proliferation Through MicroRNA-34a-5p in Human Ovarian Endometrioma.

    Hsu, Chia-Yi; Hsieh, Tsung-Hua; Tsai, Cheng-Fang; Chen, Hung-Sheng; Liang, Peir-In; Hsu, Ya-Ling; Tsai, Eing-Mei

    2016-03-01

    Endometriosis is the hormone-dependent product of endometrial tissue found outside the uterus. Recently, micro-RNAs (miRNAs) were shown to play a role in endometriotic lesion development. However, the mechanism of steroid hormones responsible for miRNA remains obscure. In the present study, we assayed for the effects of synthetic steroid hormones (danazol, progesterone, and medroxyprogesterone acetate [MPA]) on miRNAs in endometriosis. We used a global miRNA expression profile microarray to evaluate miRNA expression in endometrial mesenchymal stem cells (EN-MSCs) of ovarian endometrioma following treatment with 1 μM danazol, progesterone, or MPA. Furthermore, we selected candidate miRNAs whose expression changed more than fivefold and compared the effects of danazol, progesterone, and MPA treatments and also compared those results with controls in EN-MSCs. Among those with a fivefold change, we found 13 ectopically upregulated miRNAs in EN-MSCs. To understand the function of these 13 miRNAs, we subjected their sequences to Ingenuity Pathway Analysis. According to both the etiology and pathogenesis of endometriosis, we found that miR-199a-5p and miR-34a-5p showed specific association with the disease, including molecular and cellular functions. Steroid hormone treatment elevated the levels of miR-199a-5p and miR-34a-5p. An inhibitor of miR-34a-5p also reduced the synthetic steroid hormones effects on cell proliferation. In vivo data revealed that miRNA levels in endometriotic lesions correlated with findings following in vitro synthetic hormone treatment. Our data show the effects of synthetic steroid hormones on miRNA regulation. These findings contribute to our understanding of the molecular impact of the synthetic steroid hormones and suggest a potential mechanism for endometriosis treatment. PMID:26819477

  18. Dual Embeddedness of Governance and Strategy-Analysis Based on Interlocking Directorate Network%治理与战略的双重嵌入性——基于连锁董事网络的研究

    郑方

    2011-01-01

    迄今为止,连锁董事网络效应方面的研究还存在着很大的分歧。本文打开连锁董事网络运作的“黑箱”,以可以消除分歧的嵌入性视角进行分析.认为连锁董事网络嵌入实质上体现了治理与战略的双重嵌入性,是以连锁董事网络为载体.通过连锁董事社会资本到企业社会资本的内化,以治理与战略的整合作用而产生效应的.并因嵌入惰性和嵌入寻租而存在过度嵌入陷阱。为了不囿于连锁董事研究,本文进行了扩展性分析.探讨企业社会关系的“差序格局”和嵌入层次,以及三层次嵌入下的关系治理与网络战略.在此基础上,认为可以将嵌入的本质收益和成本理解为社会资本和社会责任.而社会责任可分为保健型和激励型两类,分别起到维持和提升社会资本的作用.并针对连锁董事网络制度设计等问题提出了相关建议.%So far, there are differences on interlocking directorate network eiffel. This paper opened the black box of interlocking directorate network, taking the perspective of embeddedness, which can eliminate differences. Interlocking directorate network embeddedness embodies double embeddedness of corporate governanee and strategy in essence, and it takes network as carrier, having effect though social capital from individual to enterprise and integrated action of corporate governance and strategy. And it is constrained within the moderate embeddedness. In order not to be limited to interlocking directorate study, extended analysis was taken in this paper, discussing the enterprise's Chaxu pattern of social relationship, embeddedness levels and corporate relational governance and network strategy under three-level embeddedness. On this basis, this paper considered social capital and social responsibility as benefit and cost of embeddedness, social responsibility can be divided into motivation and hygiene, which taking

  19. Governance Structure, Product Diversification, and Performance

    A.A.C.J. van Oijen; G.W.J. Hendrikse (George)

    2002-01-01

    textabstractProduct diversification and its financial outcomes have been studied exhaustively. However, previous literature has focused on corporations, ignoring other important legal organizations or governance structures. In this paper, we study the diversification strategies of cooperatives and c

  20. Government Response Strategy to Network Public Opinion Based on Multi-game%基于多方博弈的政府回应网络舆情策略研究

    周飞; 郭韧

    2015-01-01

    Cyberspace has become a public space for Internet users to express themselves, but it is different from the general type of public places in that where the communication is more instant, convenient with high speed, the participants in the communication can express themselves more freely and more people are involved in the communication groups, which has a significant impact on the overall pattern of Internet public opinion in China. With the social public opinion space expanded, participant characteristics of public opinion have changed. Based on game theory, in response to the situation that each participant expresses himself and chooses his own set of policies and makes strategic choices according to the objective of maximizing his own interests, a network of multilateral game is then set up, which in-volves government, netizens and internet media, and replicator dynamics equation analysis is used to select the participation strategy of each participant;each participant’ s choice is then evaluated. Finally, according the results of game theory analysis, some useful advices on appropriate government responses to network public opinion are given.%网络空间已成为网民自我表达的公共空间,它不同于一般的公共场所,具有言论传播更加及时便捷、言论更加自由、言论发表群体更加的庞大等特点,对我国的舆情格局产生了重大的影响,网络舆情有效的回应是政府公信力和网络和谐环境建立的基础。基于博弈论的研究方法,面对网络舆情各参与人有各自的策略选择集,根据最大化自身利益的目的针对网络舆情做出策略选择,建立起一个网民、政府、网媒多方参与的网络博弈场,用动态复制方程分析多个参与主体的策略选择,对政府的决策提出建议。最后根据博弈分析结果,提出了政府回应网络舆情的相关策略。

  1. RESEARCH ON BEHAVIORS OF GOVERNMENT'S TOURISM MARKETING

    Shan Quian

    2010-01-01

    Tourism has become one of the world's largest industries with broad prospects and large industrial scale. In tourism marketing, planning and packaging the image of destinations, promotion, and participating in nonprofit marketing have become inevitable choice of all levels of governments. This paper firstly discusses inevitability and necessity of government tourism marketing, and then analyzing their roles. On these basis, paper discusses the strategy of the implementation of government tour...

  2. CORPORATE GOVERNANCE RELATIONSHIP WITH STRATEGIC MANAGEMENT

    Issam MF SALTAJI

    2013-01-01

    The paper highlights on corporate governance relation through collecting and analyzing different secondary resources such as websites, lectures, published articles and books and primary resources about performance of leading companies implement new strategic models and adopt governance principles. The financial crisis has asked responsible institutions to review all the topics under discussion in this paper through adding more responsibilities on corporate governance and adopting new strategi...

  3. Engineering governance: introducing a governance meta framework.

    Brand, N.; Beens, B.; Vuuregge, E.; Batenburg, R.

    2011-01-01

    There is a need for a framework that depicts strategic choices within an organisation with regard to potential governance structures. The governance meta framework provides the necessary structure in the current developments of governance. Performance as well as conformance are embedded in this fram

  4. 美国联邦及州政府的课程管理:特点、策略及启示%The Characteristics, Strategy and Enlightenment of Curriculum Management of the U. S. Federal and State Governments

    靳玉乐; 李志超

    2012-01-01

    美国联邦及州政府课程管理具有注意加强课程政策条文的连续性,保证配套财政资助与教学改进的协调性,以及注重满足课程利益相关者的利益需求等特点。美国联邦及州政府课程管理政策重点在于形成具体明确的政策条文,加强高标准的学术性课程设置,构建“适当年度进步”的绩效问责框架等方面。鉴于此,我国当前课程管理应注意加强以下几点:以课程政策向法制化轨道迈进为前提条件,以课程参与者的思想共识为主要途径,以社会力量的监督反馈为保障。%Curriculum management of U. S. federal and state governments is characterized by their emphasis on the continuity of curriculum policies, by its integration which ensures the coordination of financial support and teaching improvement, and by its efforts in satisfying the needs and interests of the stakeholders. The focus of America's curriculum management strategy is to formulate specific policies, to strengthen high-level academic curriculum, and to build "Adequate Yearly Progress" performance accountability framework, etc. In view of the above, the scientific and rational curriculum management of curriculum reform in China should be premised on formulating a legal system of curriculum policy, reaching a consensus among the curriculum participants, and should be safeguarded by the supervision and feedback from the public.

  5. Kar5p Is Required for Multiple Functions in Both Inner and Outer Nuclear Envelope Fusion in Saccharomyces cerevisiae

    Rogers, Jason V.; Rose, Mark D.

    2014-01-01

    During mating in the budding yeast Saccharomyces cerevisiae, two haploid nuclei fuse via two sequential membrane fusion steps. SNAREs (i.e., soluble N-ethylmaleimide–sensitive factor attachment protein receptors) and Prm3p mediate outer nuclear membrane fusion, but the inner membrane fusogen remains unknown. Kar5p is a highly conserved transmembrane protein that localizes adjacent to the spindle pole body (SPB), mediates nuclear envelope fusion, and recruits Prm3p adjacent to the SPB. To sepa...

  6. BIN1 membrane curvature sensing and generation show autoinhibition regulated by downstream ligands and PI(4,5)P2.

    Wu, Tingting; Baumgart, Tobias

    2014-11-25

    In striated muscles, invaginations from the plasma membrane, termed transverse tubules (T-tubule), function in the excitation-contraction coupling machinery. BIN1 (isoform8) plays a critical role in the biogenesis of T-tubules. BIN1 contains an N-terminal BAR domain to sense and induce membrane curvature, an isoform8-specific polybasic motif (exon10) as the phosphoinositide binding module and a C-terminal Src homology 3 (SH3) domain for the recruitment of downstream proteins such as dynamin 2. Previous studies of N-BAR domains focused on elucidating mechanisms of membrane curvature sensing and generation (MC-S&G). Less is known about how MC-S&G is regulated. We found that the SH3 domain binds to the exon10 motif more strongly compared to the proline-rich domain (PRD) of dynamin 2. Furthermore, we found that the MC-S&G ability of full-length BIN1 is inhibited on membranes lacking PI(4,5)P2. Addition of PI(4,5)P2 in the membrane activates BIN1 to sense and induce membrane curvature. Co-presence of the SH3 domain and exon10 motif leads to the strongest phosphoinositide-mediated control of BIN1 function. Addition of SH3 domain ligand (such as PRD peptides), as well as addition of the water-soluble PI(4,5)P2 analogue, can both enhance the MC-S&G ability of BIN1 on membranes without PI(4,5)P2, indicating that the key to activate BIN1 is to disrupt the exon10-SH3 interaction. The nonsense mutation K436X, found in centronuclear myopathy (CNM) patients, abolishes SH3 domain binding with either exon10 or the PRD motif, resulting in increased membrane deformation capacity. Our results suggest an autoinhibition model for BIN1 that involves a synergistic regulation by membrane composition and protein-protein interactions. PMID:25350771

  7. Pension Fund governing board

    HR Department

    2008-01-01

    On 16 March and 7 May, the Pension Fund Governing Board (PFGB) held its fourth and fifth meetings The first of these meetings was primarily dedicated to the examination of the strategic asset allocation. The PFGB reaffirmed the main goal of the new strategic asset allocation: to improve the Pension Fund’s position with regard to risk by lowering overall portfolio volatility through suitable investments in less volatile asset classes such as real estate and absolute return strategies, where the return does not depend on market trends and negative growth is extremely unlikely. The finalised document will be presented to the Finance Committee and the Council at their June meetings for approval, in accordance with the provisions of the Levaux report. The PFGB also took note of the Internal Audit’s report on Pension Fund operations and decided to refer it to Working Group I as a working document for establishing a control and internal monitoring system for Pension Fund oper...

  8. A new governance space for health.

    Kickbusch, Ilona; Szabo, Martina Marianna Cassar

    2014-01-01

    Global health refers to 'those health issues which transcend national boundaries and governments and call for actions on the global forces and global flows that determine the health of people'. (Kickbusch 2006) Governance in this trans-national and cross-cutting arena can be analyzed along three political spaces: global health governance, global governance for health, and governance for global health. It is argued that the management of the interface between these three political spaces of governance in the global public health domain is becoming increasingly important in order to move the global health agenda forward. Global health governance refers mainly to those institutions and processes of governance which are related to an explicit health mandate, such as the World Health Organization; global governance for health refers mainly to those institutions and processes of global governance which have a direct and indirect health impact, such as the United Nations, World Trade Organization or the Human Rights Council; governance for global health refers to the institutions and mechanisms established at the national and regional level to contribute to global health governance and/or to governance for global health--such as national global health strategies or regional strategies for global health. It can also refer to club strategies, such as agreements by a group of countries such as the BRICS. In all three political spaces, the involvement of a multitude of state and non-state actors has become the norm--that is why issues of legitimacy, accountability and transparency have moved to the fore. The transnational nature of global health will require the engagement of all actors to produce global public goods for health (GPGH) and to ensure a rules-based and reliably financed global public health domain. PMID:24560259

  9. Observation of the 5p Rydberg states of sulfur difluoride radical by resonance-enhanced multiphoton ionization spectroscopy

    Zhang, Qun; Li, Quanxin; Yu, Shuqin; Ma, Xingxiao

    2008-01-01

    Sulfur difluoride radicals in their ground state have been produced by a "laser-free" pulsed dc discharge of the SF$_{6}$/Ar gas mixtures in a supersonic molecular beam and detected by mass-selective resonance-enhanced multilphoton ionization (REMPI) spectroscopy in the wavelength range of 408 - 420 nm. Analyses of the (3 + 1) REMPI excitation spectrum have enabled identification of three hitherto unknown Rydberg states of this radical. Following the Rydberg state labeling in our previous work [see J. Phys. Chem. A 102, 7233 (1998)], these we label the K(5p$_{1}$) [$nu_{0-0}$ = 71 837 cm$^{-1}$, $omega_{1}^{'}$(a$_{1}$ sym str) = 915 cm$^{-1}$], L(5p$_{2}$) [$nu_{0-0}$ = 72 134 cm$^{-1}$, $omega_{1}^{'}$(a$_{1}$ sym str) = 912 cm$^{-1}$], and M(5p$_{3}$) [$nu_{0-0}$ = 72 336 cm$^{-1}$, $omega_{1}^{'}$(a$_{1}$ sym str) = 926 cm$^{-1}$] Rydberg states, respectively. [Origins, relative to the lowest vibrational level of the X$^{1}$A$_{1}$ ground state, and vibrational frequencies of the symmetric S-F stretching ...

  10. Evidence for a distinct region causing a cat-like cry in patients with 5p deletions

    Gersh, M.; Goodart, S.A.; Overhauser, J. [Thomas Jefferson Univ., Philadelphia, PA (United States)] [and others

    1995-06-01

    The cri-du-chat syndrome is a contiguous gene syndrome that results from a deletion of the short arm of chromosome 5 (5p). Patients present with a cat-like cry at birth, which is usually considered diagnostic of this syndrome. Additional features of the syndrome include failure to thrive, microcephaly, hypertelorism, epicanthal folds, hypotonia, and severe mental retardation. We report on four families in which patients with 5p deletions have only the characteristic cat-like cry, with normal to mildly delayed development. The precise locations of the deletions in each family were determined by FISH using lambda phage and cosmic clones. All of the deletion breakpoints map distal to a chromosomal region that is implicated with the facial features and severe mental and developmental delay in the cri-du-chat syndrome. DNA clones mapping in the chromosomal region associated with the cat-like cry feature will be useful diagnostic tools. They will allow for the distinction between 5p deletions that will result in the severe delay observed in most cri-du-chat syndrome patients and those deletions that result in the isolated cat-like cry feature, which is associated with a better prognosis. 19 refs., 5 figs., 1 tab.

  11. Seroreactivity against Specific L5P Antigen from Mycobacterium avium subsp. paratuberculosis in Children at Risk for T1D

    Niegowska, Magdalena; Rapini, Novella; Biet, Frank; Piccinini, Simona; Bay, Sylvie; Lidano, Roberta; Manca Bitti, Maria Luisa; Sechi, Leonardo A.

    2016-01-01

    Aims/Hypothesis Although numerous environmental agents have been investigated over the years as possible triggers of type 1 diabetes (T1D), its causes remain unclear. We have already demonstrated an increased prevalence of antibodies against peptides derived from Mycobacterium avuim subsp. paratuberculosis (MAP) homologous to human zinc transporter 8 protein (ZnT8) and proinsulin in Italian subjects at risk for or affected by T1D. In this study, we compared titers of the previously detected antibodies with seroreactivity to MAP lipopentapetide (L5P) that recently emerged as a strong immunogenic component able to specifically distinguish MAP from other mycobacteria. Methods Plasma of 32 children and youth at risk for T1D including follow-up samples and 42 age-matched healthy controls (HC) recruited at the Tor Vergata University Hospital in Rome was analyzed by indirect ELISA for the presence of antibodies against MAP-derived epitopes MAP3865c133–141, MAP3865c125-133, MAP2404c70-85 and MAP1,4αgbp157-173 along with their ZnT8 and proinsulin homologs. The data were analyzed through two-tailed Mann-Whitney U test and relation between variables was determined by principal component analysis. Results Responses to L5P were not detectable in subjects whose initial seroreactivity to MAP peptides and their human homologs was lost in follow-up samples, whereas anti-L5P antibodies appeared constantly in individuals with a stable immunity against MAP antigens. The overall coincidence in positivity to L5P and the four MAP epitopes both in children at risk for T1D and HC exceeded 90%. Conclusions MAP-derived homologs may cross-react with ZnT8 and proinsulin peptides inducing immune responses at a young age in subjects predisposed for T1D. Thus, L5P may have a diagnostic value to immediately indicate the presence of anti-MAP seroreactivity when evaluation of a more complex antibody status is not required. Almost complete coincidence in responses to both types of antigens lends

  12. Seroreactivity against Specific L5P Antigen from Mycobacterium avium subsp. paratuberculosis in Children at Risk for T1D.

    Magdalena Niegowska

    Full Text Available Although numerous environmental agents have been investigated over the years as possible triggers of type 1 diabetes (T1D, its causes remain unclear. We have already demonstrated an increased prevalence of antibodies against peptides derived from Mycobacterium avuim subsp. paratuberculosis (MAP homologous to human zinc transporter 8 protein (ZnT8 and proinsulin in Italian subjects at risk for or affected by T1D. In this study, we compared titers of the previously detected antibodies with seroreactivity to MAP lipopentapetide (L5P that recently emerged as a strong immunogenic component able to specifically distinguish MAP from other mycobacteria.Plasma of 32 children and youth at risk for T1D including follow-up samples and 42 age-matched healthy controls (HC recruited at the Tor Vergata University Hospital in Rome was analyzed by indirect ELISA for the presence of antibodies against MAP-derived epitopes MAP3865c133-141, MAP3865c125-133, MAP2404c70-85 and MAP1,4αgbp157-173 along with their ZnT8 and proinsulin homologs. The data were analyzed through two-tailed Mann-Whitney U test and relation between variables was determined by principal component analysis.Responses to L5P were not detectable in subjects whose initial seroreactivity to MAP peptides and their human homologs was lost in follow-up samples, whereas anti-L5P antibodies appeared constantly in individuals with a stable immunity against MAP antigens. The overall coincidence in positivity to L5P and the four MAP epitopes both in children at risk for T1D and HC exceeded 90%.MAP-derived homologs may cross-react with ZnT8 and proinsulin peptides inducing immune responses at a young age in subjects predisposed for T1D. Thus, L5P may have a diagnostic value to immediately indicate the presence of anti-MAP seroreactivity when evaluation of a more complex antibody status is not required. Almost complete coincidence in responses to both types of antigens lends support to the involvement of MAP

  13. Business Climate and Good Governance

    Besmira Manaj

    2015-03-01

    Full Text Available This paper consists of three factors, namely: Good Governance, Business Climate and Corruption. How they affect the development product of Albania, not only as a concept, and a principle but mostly as a sensitive aspect in the integration process. There are some interpretations of this concept, but I intend to analyze the key factors and actors, their cooperation and concrete production in society. Improving governance is necessary to have an integrated long term strategy based upon a continuous cooperation between institutions and citizens. But in developing countries like Albania there are some important questions such as: How can we measure the improvement of Good Governance through policies? Has Good Governance indicated an effective way for the sustainable development? (Meisel, 2008, 6. These question give us the orientation to reflect about the process of development, social economic political behavior and how this multidimensional is transformed in product of good governance. The business cycle is strongly connected with many aspects of political-, social-, juridical aspects and good governance. Despite attempts to draft law regulations, the level of corruption and informality in Albania continues to be a major obstacle. The credibility level in the implementation of law is an indicator that affects democratization and institutional integration. At present, different reports of international institutions, define Albania as the country with the highest level of Corruption in the Balkans, which is a key factor influencing business. The ways with

  14. Voluntary Environmental Governance Arrangements

    J. van der Heijden

    2012-01-01

    Voluntary environmental governance arrangements have focal attention in studies on environmental policy, regulation and governance. The four major debates in the contemporary literature on voluntary environmental governance arrangements are studied. The literature falls short of sufficiently specify

  15. Cross-Cultural Analysiis of European e-Government Adoption

    Aykut, Arslan

    2009-01-01

    In terms of adoption, the topic of e-government has focused on the supply side (or government-related issues) such as strategies and policy, challenges, technical issues, evaluation of the usability of e-government Websites; however, less attention has been given to the demand (or citizen’s) perspective. Recent studies of the citizen adoption of e-government services suggest that trust, security, and transparency are the major issues for e-government adoption. The aim of this study ...

  16. Government cloud computing and the policies of data sovereignty

    Irion, Kristina

    2011-01-01

    Government cloud services are a new development at the intersection of electronic government and cloud computing which holds the promise of rendering government service delivery more effective and efficient. Cloud services are virtual, dynamic and potentially stateless which has triggered governments' concern about data sovereignty. This paper explores data sovereignty in relation to government cloud services and how national strategies and international policy evolve. It concludes that for c...

  17. New directions in hospital governance.

    Shortell, S M

    1989-01-01

    This article suggests new directions for hospital governance to meet the demands of a rapidly changing health care environment. Board members must increasingly play roles as risk takers, strategic directors, experts, mentors, and evaluators. Lessons from other industries regarding risk taking, use of expertise, and streamlining decision making must be adapted to meet hospital needs. Recent data suggest that these needs may still differ by hospital ownership despite a convergence in investor-owned and not-for-profit corporate structures. The effectiveness of hospital boards in the future will depend on their ability to: (1) manage a diverse group of stakeholders; (2) involve physicians in the management and governance process; (3) meet the governance needs of multi-institutional systems and hospital restructuring; (4) meet the challenges of diversification and vertical integration; and (5) understand strategy formulation and implementation as interdependent and interrelated processes. PMID:10303235

  18. Construction sector development: frames and governance responses

    Jensen, Jens Stissing; Gottlieb, Stefan C.; Thuesen, Christian Langhoff

    2011-01-01

    activities may be governed. Based on a case study of the sector development activities in the Danish construction industry, this paper argues that governance strategies should not necessarily be designed to ensure the development of a single industrial conceptualization. First, drawing on concepts from......The governance of construction sector development constitutes an important policy issue in many European countries due to the increasing impact that construction as well as the built environment have on gross domestic product and the environment. Previous studies have discussed how national...... composed of multiple incommensurable sector representations, then the most productive governance response may be to recognize and accept their conflicting strategic implications....

  19. Deactivation of two-photon excited Xe(5p56p,6p',7p) and Kr(4p55p) in xenon and krypton

    Lifetimes and bimolecular quenching rate constants have been determined for two-photon laser excited states of Xe*(5p56p,5p56p',5p57p) and Kr*(4p55p) in krypton and xenon buffer gases. Collisional mixing between Kr*5p[5/2]2 and Kr*5p[5/2]3 in krypton is observed and analyzed using a coupled two-state model to obtain the rate of mixing. The measured rate constants for quenching of Xe*(6p',7p) by krypton are 15%--20% smaller than those measured previously in xenon while bimolecular rates for the Kr*(5p) states are an order of magnitude larger in xenon than those in a krypton buffer. Measurements of state-to-state rate constants for deactivation and excitation transfer are also reported for these states in krypton and xenon buffer gases

  20. miR-146b-5p within BCR-ABL1-Positive Microvesicles Promotes Leukemic Transformation of Hematopoietic Cells.

    Zhang, Hong-Mei; Li, Qing; Zhu, Xiaojian; Liu, Wei; Hu, Hui; Liu, Teng; Cheng, Fanjun; You, Yong; Zhong, Zhaodong; Zou, Ping; Li, Qiubai; Chen, Zhichao; Guo, An-Yuan

    2016-05-15

    Evidence is accumulating that extracellular microvesicles (MV) facilitate progression and relapse in cancer. Using a model in which MVs derived from K562 chronic myelogenous leukemia (CML) cells transform normal hematopoietic transplants into leukemia-like cells, we defined the underlying mechanisms of this process through gene-expression studies and network analyses of transcription factors (TF) and miRNAs. We found that antitumor miRNAs were increased and several defense pathways were initiated during the early phases of oncogenic transformation. Later, oncomiRs and genes involved in cell cycle, DNA repair, and energy metabolism pathways were upregulated. Regulatory network analyses revealed that a number of TFs and miRNAs were responsible for the pathway dysregulation and the oncogenic transformation. In particular, we found that miR-146b-5p, which was highly expressed in MVs, coordinated the regulation of cancer-related genes to promote cell-transforming processes. Notably, treatment of recipient cells with MV derived from K562 cells expressing mimics of miR-146b-5p revealed that it accelerated the transformation process in large part by silencing the tumor-suppressor NUMB High levels of miR-146b-5p also enhanced reactive oxygen species levels and genome instability of recipient cells. Taken together, our finding showed how upregulation of oncogenic miRNAs in MVs promote hematopoetic cells to a leukemic state, as well as a demonstration for TF and miRNA coregulatory analysis in exploring the dysregulation of cancers and discovering key factors. Cancer Res; 76(10); 2901-11. ©2016 AACR. PMID:27013199

  1. The discharge mode transition and O(5p1) production mechanism of pulsed radio frequency capacitively coupled plasma

    The discharge mode transition from uniform plasma across the gas gap to the α mode happens at the rising phase of the pulsed radio frequency capacitively coupled plasma (PRF CCP). This transition is attributed to the fast increasing stochastic heating at the edge of sheath. In the second stage with the stable current and voltage amplitude, the consistency between experimental and numerical spatial-temporal 777 nm emission profile suggests that He* and He2* dominate the production of O(5p1) through dissociation and excitation of O2. Finally, the sterilization efficiency of PRF CCP is found to be higher than that of plasma jet.

  2. The discharge mode transition and O(5p1) production mechanism of pulsed radio frequency capacitively coupled plasma

    Liu, X. Y.; Hu, J. T.; Liu, J. H.; Xiong, Z. L.; Liu, D. W.; Lu, X. P.; Shi, J. J.

    2012-07-01

    The discharge mode transition from uniform plasma across the gas gap to the α mode happens at the rising phase of the pulsed radio frequency capacitively coupled plasma (PRF CCP). This transition is attributed to the fast increasing stochastic heating at the edge of sheath. In the second stage with the stable current and voltage amplitude, the consistency between experimental and numerical spatial-temporal 777 nm emission profile suggests that He* and He2* dominate the production of O(5p1) through dissociation and excitation of O2. Finally, the sterilization efficiency of PRF CCP is found to be higher than that of plasma jet.

  3. Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor-Positive, Lower Grade Breast Cancer

    Milne, Roger L; Goode, Ellen L; García-Closas, Montserrat;

    2011-01-01

    Consortium. METHODS: Data were combined from 37 studies, including 40,972 invasive cases, 1,398 cases of ductal carcinoma in situ (DCIS), and 46,334 controls, all of white European ancestry, as well as 3,007 invasive cases and 2,337 controls of Asian ancestry. Associations overall and by tumor invasiveness......, and 3/4, respectively; P(trend) = 5 × 10(-7)]. CONCLUSION: 5p12 is a breast cancer susceptibility locus for PR-positive, lower grade breast cancer. Impact: Multicenter fine-mapping studies of this region are needed as a first step to identifying the causal variant or variants. Cancer Epidemiol...

  4. MicroRNA-155-5p is associated with oral squamous cell carcinoma metastasis and poor prognosis

    Baba, Osamu; Hasegawa, Shogo; Nagai, Hiroki; Uchida, Fumihiko; Yamatoji, Masanobu; Kanno, Naomi I.; Yamagata, Kenji; Sakai, Satoshi; Yanagawa, Toru; BUKAWA, HIROKI

    2016-01-01

    BackgroundAbnormal miRNA expression was recently implicated in the metastasis of oral squamous cell carcinoma (OSCC) and with a poor prognosis. The initiation of the invasion-metastasis cascade involves epithelial-mesenchymal transition (EMT). Our aim was to clarify how miRNA, especially miR-155-5p misexpression contributes to OSCC metastasis through EMT.MethodsWe collected tumor samples from 73 subjects with OSCC. The samples were analyzed by quantitative reverse-transcription polymerase cha...

  5. Governance, Government, and the Search for New Provider Models.

    Saltman, Richard B; Duran, Antonio

    2016-01-01

    A central problem in designing effective models of provider governance in health systems has been to ensure an appropriate balance between the concerns of public sector and/or government decision-makers, on the one hand, and of non-governmental health services actors in civil society and private life, on the other. In tax-funded European health systems up to the 1980s, the state and other public sector decision-makers played a dominant role over health service provision, typically operating hospitals through national or regional governments on a command-and-control basis. In a number of countries, however, this state role has started to change, with governments first stepping out of direct service provision and now de facto pushed to focus more on steering provider organizations rather than on direct public management. In this new approach to provider governance, the state has pulled back into a regulatory role that introduces market-like incentives and management structures, which then apply to both public and private sector providers alike. This article examines some of the main operational complexities in implementing this new governance reality/strategy, specifically from a service provision (as opposed to mostly a financing or even regulatory) perspective. After briefly reviewing some of the key theoretical dilemmas, the paper presents two case studies where this new approach was put into practice: primary care in Sweden and hospitals in Spain. The article concludes that good governance today needs to reflect practical operational realities if it is to have the desired effect on health sector reform outcome. PMID:26673647

  6. Metropolitan Governance Reforms: The Case of Seoul Metropolitan Government

    Nicholas Snyder

    2012-10-01

    Full Text Available Seoul is transforming into a global city that is competitive with many of the most notable cities in the world such as Tokyo, New York, and London. Seoul’s metropolitan governance structure is uniquely suited to the Korean peninsula and has been able to be dynamic in order to adapt to political changes the country has experienced. This article examines the initiatives behind metropolitan governance reforms in Seoul and the factors that play an important role in influencing the current governance structure. The Seoul Metropolitan Government (SMG is set on improving the lives of citizens and ensuring they are happy with their city through transparency, accountability, efficiency, and effectiveness of government among other things. This region has become a strong contributor to the economic growth of the county and helped to create opportunities to attract and retain businesses, implement innovative investment projects and develop a talented workforce. Amongst other reasons, Seoul’s solid fiscal system has allowed the city to build the necessary organizational capacity for SMG as well. Additionally, Seoul citizens enjoy a good quality of life because of the educational options, employment opportunities, housing spaces, leisure activities, and cultural experiences found in the city. There are still some challenges ahead but Seoul realizes the importance of civic participation for capacity building and sustainability. One of Seoul’s strategies to promoting sustainable living within the city is its ability to engage the public. By promoting citizen participation and feedback, Seoul feels that it will gain new perceptivities during the policy decision-making process. The city’s current governance methods continue to succeed because the leaders at SMG understand what is essential to executing successful governance reform: citizens.

  7. Metropolitan Governance Reforms: The Case of Seoul Metropolitan Government

    Nicholas Snyder

    2016-02-01

    Full Text Available Seoul is transforming into a global city that is competitive with many of the most notable cities in the world such as Tokyo, New York, and London. Seoul's metropolitan governance structure is uniquely suited to the Korean peninsula and has been able to be dynamic in order to adapt to political changes the country has experienced. This article examines the initiatives behind metropolitan governance reforms in Seoul and the factors that play an important role in influencing the current governance structure. The Seoul Metropolitan Government (SMG is set on improving the lives of citizens and ensuring they are happy with their city through transparency, accountability, efficiency, and effectiveness of government among other things. This region has become a strong contributor to the economic growth of the county and helped to create opportunities to attract and retain businesses, implement innovative investment projects and develop a talented workforce. Amongst other reasons, Seoul's solid fiscal system has allowed the city to build the necessary organizational capacity for SMG as well. Additionally, Seoul citizens enjoy a good quality of life because of the educational options, employment opportunities, housing spaces, leisure activities, and cultural experiences found in the city. There are still some challenges ahead but Seoul realizes the importance of civic participation for capacity building and sustainability. One of Seoul's strategies to promoting sustainable living within the city is its ability to engage the public. By promoting citizen participation and feedback, Seoul feels that it will gain new perceptivities during the policy decision-making process. The city's current governance methods continue to succeed because the leaders at SMG understand what is essential to executing successful governance reform: citizens.

  8. Governance, Government, and the Search for New Provider Models

    Richard B. Saltman

    2016-01-01

    Full Text Available A central problem in designing effective models of provider governance in health systems has been to ensure an appropriate balance between the concerns of public sector and/or government decision-makers, on the one hand, and of non-governmental health services actors in civil society and private life, on the other. In tax-funded European health systems up to the 1980s, the state and other public sector decision-makers played a dominant role over health service provision, typically operating hospitals through national or regional governments on a command-and-control basis. In a number of countries, however, this state role has started to change, with governments first stepping out of direct service provision and now de facto pushed to focus more on steering provider organizations rather than on direct public management. In this new approach to provider governance, the state has pulled back into a regulatory role that introduces market-like incentives and management structures, which then apply to both public and private sector providers alike. This article examines some of the main operational complexities in implementing this new governance reality/strategy, specifically from a service provision (as opposed to mostly a financing or even regulatory perspective. After briefly reviewing some of the key theoretical dilemmas, the paper presents two case studies where this new approach was put into practice: primary care in Sweden and hospitals in Spain. The article concludes that good governance today needs to reflect practical operational realities if it is to have the desired effect on health sector reform outcome.

  9. Why Governments Intervene

    Knudsen, Jette Steen; Brown, Dana

    2015-01-01

    Why are national governments increasingly adopting policies on corporate social responsibility (CSR)? Government CSR policies have been explained either as a means of substituting or supporting (mirroring) domestic political-economic institutions and policies, or as a means for government to...... government goals in this regard are not necessarily pre-defined....

  10. Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression.

    Kote-Jarai, Zsofia; Saunders, Edward J; Leongamornlert, Daniel A; Tymrakiewicz, Malgorzata; Dadaev, Tokhir; Jugurnauth-Little, Sarah; Ross-Adams, Helen; Al Olama, Ali Amin; Benlloch, Sara; Halim, Silvia; Russell, Roslin; Russel, Roslin; Dunning, Alison M; Luccarini, Craig; Dennis, Joe; Neal, David E; Hamdy, Freddie C; Donovan, Jenny L; Muir, Ken; Giles, Graham G; Severi, Gianluca; Wiklund, Fredrik; Gronberg, Henrik; Haiman, Christopher A; Schumacher, Fredrick; Henderson, Brian E; Le Marchand, Loic; Lindstrom, Sara; Kraft, Peter; Hunter, David J; Gapstur, Susan; Chanock, Stephen; Berndt, Sonja I; Albanes, Demetrius; Andriole, Gerald; Schleutker, Johanna; Weischer, Maren; Canzian, Federico; Riboli, Elio; Key, Tim J; Travis, Ruth C; Campa, Daniele; Ingles, Sue A; John, Esther M; Hayes, Richard B; Pharoah, Paul; Khaw, Kay-Tee; Stanford, Janet L; Ostrander, Elaine A; Signorello, Lisa B; Thibodeau, Stephen N; Schaid, Dan; Maier, Christiane; Vogel, Walther; Kibel, Adam S; Cybulski, Cezary; Lubinski, Jan; Cannon-Albright, Lisa; Brenner, Hermann; Park, Jong Y; Kaneva, Radka; Batra, Jyotsna; Spurdle, Amanda; Clements, Judith A; Teixeira, Manuel R; Govindasami, Koveela; Guy, Michelle; Wilkinson, Rosemary A; Sawyer, Emma J; Morgan, Angela; Dicks, Ed; Baynes, Caroline; Conroy, Don; Bojesen, Stig E; Kaaks, Rudolf; Vincent, Daniel; Bacot, François; Tessier, Daniel C; Easton, Douglas F; Eeles, Rosalind A

    2013-06-15

    Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the telomerase reverse transcriptase (TERT) gene that encodes TERT. To comprehensively evaluate the association between genetic variation across this region and PrCa, we performed a fine-mapping analysis by genotyping 134 SNPs using a custom Illumina iSelect array or Sequenom MassArray iPlex, followed by imputation of 1094 SNPs in 22 301 PrCa cases and 22 320 controls in The PRACTICAL consortium. Multiple stepwise logistic regression analysis identified four signals in the promoter or intronic regions of TERT that independently associated with PrCa risk. Gene expression analysis of normal prostate tissue showed evidence that SNPs within one of these regions also associated with TERT expression, providing a potential mechanism for predisposition to disease. PMID:23535824

  11. Functional link between Rab GTPase-mediated membrane trafficking and PI4,5P2 signaling.

    Li, Cuifang; Kita, Ayako; Hashimoto, Yuuka; Ihara, Misako; Kato, Ayaka; Ogura, Naoya; Doi, Akira; Oku, Masahide; Itoh, Toshiki; Sakai, Yasuyoshi; Sugiura, Reiko

    2014-03-01

    Fission yeast its3(+) encodes an essential phosphatidylinositol-4-phosphate 5-kinase (PI4P5K) that regulates cell integrity and cytokinesis. We performed a genetic screen to identify genes that function in PI4P5K-mediated signaling, and identified gyp10(+) encoding a Rab GTPase-activating protein (GAP), a negative regulator for Rab GTPase signaling. Its3 overproduction caused growth defects and abnormal cytoplasmic accumulation of the Its3 protein, which can be stained by calcofluor. Notably, Its3 overproducing cells displayed abnormal membranous structures, multilamella Golgi and fragmented vacuoles showed by Electron microscopy. Furthermore, the excess cytoplasmic Its3 structure partly colocalized with the fluorescence of FM4-64. Gyp10 rescued both growth defects and abnormal Its3 localization when it was over-expressed. Gyp10 functionally interacted with the Rab GTPases Ypt3 and Ryh1, both of which regulate Golgi membrane trafficking. Consistently, mutation or deletion of Ypt3 and Ryh1 suppressed phenotypes associated with Its3 overproduction. Importantly, the plasma membrane localization of Its3 was also affected by the impairment of the Ypt3/Ryh1 Rab membrane trafficking, thus suggesting that membrane trafficking events regulated by two Rab GTPases functionally interacts with PI4,5P2 signaling. These results suggest a mechanism whereby PI4P5K signaling/localization is affected by Golgi membrane trafficking, thus provide a functional link between the PI4,5P2 signaling and Rab-mediated trafficking. PMID:24350606

  12. Does E-Government Improve Government Capacity?

    Kochanova, Anna; Hasnain, Zahid; Larson, Bradley

    2016-01-01

    Using a cross-country data set on e-government systems, this paper analyzes whether e-filing of taxes and e-procurement adoption improves the capacity of governments to raise and spend resources through the lowering of tax compliance costs, improvement of public procurement competitiveness, and reduction of corruption. The paper finds that information and communications technology can help...

  13. Institutional Impacts of the Local Government Reform Program on Good Local Governance in Tanzania

    Boniface E.S. Mgonja; Charles Tundui

    2012-01-01

    Ever since the early 1990s, Tanzania’s government has embarked upon ambitious and far-reaching reform programs to improve the socioeconomic condition of the country. Among them was the development of anti-corruption strategies and the local government reform program. Overall, these reform programs were expected to improve good governance through reformed and autonomous local institutions. As such, this paper provides a detailed analysis of two reform initiatives, namely, anti-corruption strat...

  14. From Good Governance to Developmental Governance - How Policies, Institutions and Politics Matter

    Lauridsen, Laurids Sandager

    2012-01-01

    The present global financial and economic crisis offers an opportunity to rethink the relative roles of state and market as well as of globalisation and national development strategies in the political economy of development. It has become more difficult to argue that globalisation has rendered...... governance – is the most promising path for future research on governance and economic transformation....

  15. MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)

    Liu, Dachuang [Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009 (China); Department of Urology, Xuzhou Central Hospital Affiliated with Southeast University, Xuzhou, Jiangsu Province 221009 (China); Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009 (China); Tao, Tao; Xu, Bin; Chen, Shuqiu; Liu, Chunhui [Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009 (China); Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009 (China); Zhang, Lei; Lu, Kai [Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009 (China); Huang, Yeqing; Jiang, Liang [Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009 (China); Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009 (China); Zhang, Xiaowen [Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009 (China); Huang, Xiaoming [Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009 (China); Zhang, Lihua [Department of Pathology, Zhongda Hospital Affiliated with Southeast University, Nanjing, Jiangsu Province 210009 (China); Han, Conghui [Department of Urology, Xuzhou Central Hospital Affiliated with Southeast University, Xuzhou, Jiangsu Province 221009 (China); Chen, Ming, E-mail: mingchenseu@gmail.com [Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009 (China); Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009 (China)

    2014-02-28

    Highlights: • The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date. • We found that the expression of miR-361-5p in CRPC was lower than in ADPC. • MiR-361-5p suppressed DU145 cell proliferation and triggered apoptosis. • STAT6 is a direct target of miR-361-5p. • STAT6 enhances the expression of Bcl-xL at the transcriptional level. - Abstract: Castration-resistant prostate cancer (CRPC), whose pathogenesis is known to be regulated by microRNAs (miRNAs), has a poor prognosis. In our present study, we found that the expression of miR-361-5p in CRPC was lower than in androgen-dependent prostate cancer (ADPC), indicating that miR-361-5p may play an important role in the progression of ADPC to CRPC. The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date. Our findings suggest that miR-361-5p is a suppressor in CRPC. Signal transducer and activator of transcription-6 (STAT6), a direct target of miR-361-5p, enhances the expression of B-cell lymphoma-extra large (Bcl-xL), while miR-361-5p inhibits its expression through STAT6. Therefore, miR-361-5p has great clinical significance in preventing the malignant progression of PCa.

  16. Arranged marriage in lipid signalling? The limited choices of PtdIns(4,5)P2 in finding the right partner.

    Heilmann, M; Heilmann, I

    2013-09-01

    Inositol-containing phospholipids (phosphoinositides, PIs) control numerous cellular processes in eukaryotic cells. For plants, a key involvement of PIs has been demonstrated in the regulation of membrane trafficking, cytoskeletal dynamics and in processes mediating the adaptation to changing environmental conditions. Phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P(2)) mediates its cellular functions via binding to various alternative target proteins. Such downstream targets of PtdIns(4,5)P(2) are characterised by the possession of specific lipid-binding domains, and binding of the PtdIns(4,5)P(2) ligand exerts effects on their activity or localisation. The large number of potential alternative binding partners - and associated cellular processes - raises the question how alternative or even contrapuntal effects of PtdIns(4,5)P(2) are orchestrated to enable cellular function. This article aims to provide an overview of recent insights and new views on how distinct functional pools of PtdIns(4,5)P(2) are generated and maintained. The emerging picture suggests that PtdIns(4,5)P(2) species containing different fatty acids influence the lateral mobility of the lipids in the membrane, possibly enabling specific interactions of PtdIns(4,5)P(2) pools with certain downstream targets. PtdIns(4,5)P(2) pools with certain functions might also be defined by protein-protein interactions of PI4P 5-kinases, which pass PtdIns(4,5)P(2) only to certain downstream partners. Individually or in combination, PtdIns(4,5)P(2) species and specific protein-protein interactions of PI4P 5-kinases might contribute to the channelling of PtdIns(4,5)P(2) signals towards specific functional effects. The dynamic nature of PI-dependent signalling complexes with specific functions is an added challenge for future studies of plant PI signalling. PMID:23627419

  17. MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)

    Highlights: • The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date. • We found that the expression of miR-361-5p in CRPC was lower than in ADPC. • MiR-361-5p suppressed DU145 cell proliferation and triggered apoptosis. • STAT6 is a direct target of miR-361-5p. • STAT6 enhances the expression of Bcl-xL at the transcriptional level. - Abstract: Castration-resistant prostate cancer (CRPC), whose pathogenesis is known to be regulated by microRNAs (miRNAs), has a poor prognosis. In our present study, we found that the expression of miR-361-5p in CRPC was lower than in androgen-dependent prostate cancer (ADPC), indicating that miR-361-5p may play an important role in the progression of ADPC to CRPC. The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date. Our findings suggest that miR-361-5p is a suppressor in CRPC. Signal transducer and activator of transcription-6 (STAT6), a direct target of miR-361-5p, enhances the expression of B-cell lymphoma-extra large (Bcl-xL), while miR-361-5p inhibits its expression through STAT6. Therefore, miR-361-5p has great clinical significance in preventing the malignant progression of PCa

  18. miR-450b-5p Suppresses Stemness and the Development of Chemoresistance by Targeting SOX2 in Colorectal Cancer.

    Jin, Yinghu; Jiang, Zheng; Guan, Xu; Chen, Yinggang; Tang, Qingchao; Wang, Guiyu; Wang, Xishan

    2016-05-01

    To investigate the role of miR-450b-5p, a newly identified microRNA, located in the Xq26 region, in development of chemoresistance in colorectal cancer (CRC), and to explore the underlying mechanism by which miR-450b-5p regulates this process. In this study, we demonstrated that expression of miR-450b-5p was downregulated in recurrent CRC tissues. We found that expression of miR-450b-5p was significantly inhibited in response to 5-fluorouracil (5-FU) treatment in HT-29 cells and HCT-116 cells. Importantly, overexpression of miR-450b-5p in 5-FU-resistant HT-29 cells reduced cell viability, but elevated DNA fragmentation levels and caspase-3 activity were induced by treatment with 5-FU. Conversely, inhibition of miR-450b-5p enhanced resistance to 5-FU, and promoted cell viability in HCT-116 cells. Mechanistically, we found that miR-450b-5p directly targeted SOX2, an essential factor in stem cells. Expression of miR-450b-5p was negatively correlated to the expression of SOX2, the percentages of CD133(+) cells present, and sphere-forming capacity in CRC cells. Finally, depletion of SOX2 abolished the effects of suppression of miR-450b-5p on stemness and chemoresistance in HT29 cells. We have demonstrated that miR-450b-5p inhibits stemness and development of chemoresistance to 5-FU in CRC cells. These results indicate that miR-450b-5p may be a key determinant of 5-FU sensitivity, and may represent a novel therapeutic target to facilitate chemotherapy for CRC. PMID:26845645

  19. The Role of Governance in Corporate Social Responsibility

    De Graaf, J. F.; Stoelhorst, W. J

    2013-01-01

    This article extends the corporate social performance (CSP) model by studying the role of governance structures and governance systems in shaping corporate social responsibility. The authors argue that a governance perspective offers a fruitful research strategy both to study empirically how firms b

  20. Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell

    Highlights: ► miR-199a-5p levels were significantly decreased after cisplatin treatment. ► Cisplatin treatment induced autophagy activation. ► Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell. -- Abstract: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Systemic chemotherapy plays an important role in the treatment of patients with advanced liver cancer. However, chemoresistance to cisplatin is a major limitation of cisplatin-based chemotherapy in the clinic, and the underlying mechanism of such resistance is not fully understood. In the study, we found that miR-199a-5p levels were significantly reduced in HCC patients treated with cisplatin-based chemotherapy. Cisplatin treatment also resulted in decreased miR-199a-5p levels in human HCC cell lines. Forced expression of miR-199a-5p promoted cisplatin-induced inhibition of cell proliferation. Cisplatin treatment activated autophagy in Huh7 and HepG2 cells, which increased cell proliferation. We further demonstrated that downregulated miR-199a-5p enhanced autophagy activation by targeting autophagy-associated gene 7 (ATG7). More important, autophagy inhibition abrogated miR-199a-5p downregulation-induced cell proliferation. These data demonstrated that miR-199a-5p/autophagy signaling represents a novel pathway regulating chemoresistance, thus offering a new target for chemotherapy of HCC.

  1. miRNA 206 and miRNA 574-5p are highly expression in coronary artery disease

    Zhou, Jianqing; Shao, Guofeng; Chen, Xiaoliang; Yang, Xi; Huang, Xiaoyan; Peng, Ping; Ba, Yanna; Zhang, Lin; Jehangir, Tashina; Bu, Shizhong; Liu, Ningsheng; Lian, Jiangfang

    2015-01-01

    Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide. Innovative diagnostic biomarkers are a pressing need for this disease. miRNAs profiling is an innovative method of identifying biomarkers for many diseases and could be proven as a powerful tool in the diagnosis and treatment of CAD. We performed miRNA microarray analysis from the plasma of three CAD patients and three healthy controls. Subsequently, we performed quantitative real-time PCR (qRT-PCR) analysis of miRNA expression in plasma of another 67 CAD patients and 67 healthy controls. We identified two miRNAs (miR-206 and miR-574-5p) that were significantly up-regulated in CAD patients as compared with healthy controls (P<0.05). The receiver operating characteristic (ROC) curves indicated these two miRNAs had great potential to provide sensitive and specific diagnostic value for CAD. PMID:26685009

  2. Interactions of solute (3p, 4p, 5p and 6p) with solute, vacancy and divacancy in bcc Fe

    You, Yu-Wei; Kong, Xiang-Shan; Wu, Xue-Bang; Liu, Wei [Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, P.O. Box 1129, Hefei 230031 (China); Liu, C.S., E-mail: csliu@issp.ac.cn [Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, P.O. Box 1129, Hefei 230031 (China); Fang, Q.F. [Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, P.O. Box 1129, Hefei 230031 (China); Chen, J.L.; Luo, G.-N. [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Wang, Zhiguang [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China)

    2014-12-15

    Solute–vacancy binding energy is a key quantity in understanding solute diffusion kinetics and phase segregation, and may help choice of alloy compositions for future material design. However, the binding energy of solute with vacancy is notoriously difficult to measure and largely unknown in bcc Fe. With first-principles method, we systemically calculate the binding energies of solute (3p, 4p, 5p and 6p alloying solutes are included) with vacancy, divacancy and solute in bcc Fe. The binding energy of Si with vacancy in the present work is in good consistent with experimental value available. All the solutes considered are able to form stable solute–vacancy, solute–divacancy complexes, and the binding strength of solute–divacancy is about two times larger than that of solute–vacancy. Most solutes could not form stable solute–solute complexes except S, Se, In and Tl. The factors controlling the binding energies are analyzed at last.

  3. Interactions of solute (3p, 4p, 5p and 6p) with solute, vacancy and divacancy in bcc Fe

    Solute–vacancy binding energy is a key quantity in understanding solute diffusion kinetics and phase segregation, and may help choice of alloy compositions for future material design. However, the binding energy of solute with vacancy is notoriously difficult to measure and largely unknown in bcc Fe. With first-principles method, we systemically calculate the binding energies of solute (3p, 4p, 5p and 6p alloying solutes are included) with vacancy, divacancy and solute in bcc Fe. The binding energy of Si with vacancy in the present work is in good consistent with experimental value available. All the solutes considered are able to form stable solute–vacancy, solute–divacancy complexes, and the binding strength of solute–divacancy is about two times larger than that of solute–vacancy. Most solutes could not form stable solute–solute complexes except S, Se, In and Tl. The factors controlling the binding energies are analyzed at last

  4. JR-spectra and structure of MoO3-V2O5-P2O5 system glasses

    Vitrification range is ascertained, IR absorption spectra are studied and the main structural characteristics of anion net in glasses of the system MoO3-V2O5-P2O5 are determined. The reference of the absorption bands in the spectra to the vibrations of P-O, V-O, No-O bonds and P-O-P, V-O-V, Mo-O-Mo bridges is made. It is shown that disordered net of the glasses consists of phosphate, vanadate and molybdate chains bound by P-O-V and P-O-Mo bridges, which are respectively built of POO3/2, VOO3/2 tetrahedrons and MoO2O4/2 octahedrons. According to concentrational dependence of the spectra the character of the change in structural-chemical composition of the glasses depending on the component concentration is clarified

  5. Microstructure, thermal, and mechanical properties of nanostructured Cu-9.5Ni-4.0Sn-7.5P

    Li, J.; Wang, T. M.

    1995-04-01

    Nanostructured Cu-9.5Ni-4.0Sn-7.5P samples represent a polycrystal microstructure of nanometer-sized α-Cu and Cu3P crystallites for crystallite sizes less than 20 nm and of nanometer-sized α-Cu, Cu3P, and Ni2P crystallites for crystallite sizes greater than 20 nm. The specific heat values between 300 K and 400 K for the nanostructured sample with crystallite size of 10 nm are about 20% higher than for the amorphous sample and about 40% higher than for the coarse-grained sample. The hardness of the nanostructured sample with crystallite size of 10 nm is 30% higher than that of the amorphous sample and 110% higher than that of the coarse-grained sample. The variation in hardness with the crystallite size for the nanostructured samples follows the Hall-Petch relationship.

  6. Association between 5p12 genomic markers and breast cancer susceptibility: evidence from 19 case-control studies.

    Xiaofeng Wang

    Full Text Available BACKGROUND: The association between polymorphisms on 5p12 and breast cancer (BC has been widely evaluated since it was first identified through genome-wide association approach; however, the studies have yielded contradictory results. We sought to investigate this inconsistency by performing a comprehensive meta-analysis on two wildly studied polymorphisms (rs10941679 and rs4415084 on 5p12. METHODS: Databases including Pubmed, EMBASE, Web of Science, EBSCO, and Cochrane Library databases were searched to find relevant studies. Odds ratios (ORs with 95% confidence intervals (CIs were used to assess the strength of association. The random-effects model was applied, addressing heterogeneity and publication bias. RESULTS: A total of 19 articles involving 100,083 cases and 163,894 controls were included. An overall random-effects per-allele OR of 1.09 (95% CI: 1.06-1.12; P = 4.5 × 10(-8 and 1.09 (95% CI: 1.05-1.12; P = 4.2 × 10(-7 was found for the rs10941679 and rs4415084 polymorphism respectively. Significant results were found in Asians and Caucasians when stratified by ethnicity; whereas no significant associations were found among Africans/African-Americans. Similar results were also observed using dominant or recessive genetic models. In addition, we find both rs4415084 and rs10941679 conferred significantly greater risks of ER-positive breast cancer than of ER-negative tumors. CONCLUSIONS: Our findings demonstrated that rs10941679-G allele and rs4415084-T allele might be risk-conferring factors for the development of breast cancer, especially in Caucasians and East-Asians.

  7. Governance of disaster risk reduction in Cameroon: The need to empower local government

    Henry N. Bang

    2013-01-01

    Full Text Available The impact of natural hazards and/or disasters in Cameroon continues to hit local communities hardest, but local government lacks the ability to manage disaster risks adequately. This is partly due to the fact that the necessity to mainstream disaster risk reduction into local governance and development practices is not yet an underlying principle of Cameroon’s disaster management framework. Using empirical and secondary data, this paper analyses the governance of disaster risks in Cameroon with particular focus on the challenges local government faces in implementing disaster risk reduction strategies. The hypothesis is that the governance of disaster risks is too centralised at the national level, with huge implications for the effective governance of disaster risks at the local level. Although Cameroon has reinvigorated efforts to address growing disaster risks in a proactive way, it is argued that the practical actions are more reactive than proactive in nature. The overall aim is to explore the challenges and opportunities that local government has in the governance of disaster risks. Based on the findings from this research, policy recommendations are suggested on ways to mainstream disaster risk reduction strategies into local governance, and advance understanding and practice in the local governance of disaster risks in the country.

  8. Flood risk governance arrangements in Europe

    Matczak, P.; Lewandowski, J.; Choryński, A.; Szwed, M.; Kundzewicz, Z. W.

    2015-06-01

    The STAR-FLOOD (Strengthening and Redesigning European Flood Risk Practices Towards Appropriate and Resilient Flood Risk Governance Arrangements) project, funded by the European Commission, investigates strategies for dealing with flood risk in six European countries: Belgium, the UK, France, the Netherlands, Poland and Sweden and in 18 vulnerable urban regions in these countries. The project aims to describe, analyse, explain, and evaluate the main similarities and differences between the selected EU Member States in terms of development and performance of flood risk governance arrangements. It also discusses the scientific and societal importance of these similarities and differences. Attention is paid to identification and characterization of shifts in flood risk governance arrangements and in flood risk management strategies and to determination of triggering factors and restraining factors. An assessment of a change of resilience and appropriateness (legitimacy, effectiveness, efficiency) of flood risk governance arrangements in Poland is presented and comparison with other European countries is offered.

  9. De-institutionalising governance?

    Kay, Adrian; Daugbjerg, Carsten

    2015-01-01

    Despite several generations of literature on governance and the instruments involved, micro-foundational frameworks remain lacking to describe and model the positive, negative and confused feedback dynamics within any set of governance arrangements. In response, this article addresses the argument...... common in various historical accounts of a shift from government to governance that governance is a process of deinstitutionalisation. In doing so, governance is revealed not as the simple absence of institutions, but rather as a shift in the nature, composition and diversity of institutions and the...... instruments adopted by them. This raises important questions about the design and use of instruments and their institutional effects and legitimacy as micro-foundations of governance, and also about the ability of governments to control them given the nature and significance of feedback dynamics....

  10. Government and Business

    Campbell, John L.

    2015-01-01

    There is a vast literature about the relationships between government and business in advanced capitalist societies.......There is a vast literature about the relationships between government and business in advanced capitalist societies....

  11. Practice of good governance and corporate governance

    Bălăceanu Cristina; Tutor Predonu Andreea – Monica

    2010-01-01

    Corporate governance reforms are occurring in countries around the globe and potentially impacting the population of the entire planet. In developing countries, such reforms occur in a larger context that is primarily defined by previous attempts at promoting “development” and recent processes of economic globalization. In this context, corporate governance reforms (in combination with the liberalising reforms associated with economic globalization), in effect re...

  12. Corporate governance quality

    Bocean, Claudiu George

    2008-01-01

    Corporate governance quality in most countries has overall improved, although to varying degrees and with a few notable exceptions. Corporate governance issues are especially important in emerging countries, since these countries do not have the long-established financial institution infrastructure to deal with corporate governance issues. This paper discusses how emerging countries are dealing with corporate governance quality issues. In emerging countries the impact of improvements in corpo...

  13. Privacy and Open Government

    Teresa Scassa

    2014-01-01

    The public-oriented goals of the open government movement promise increased transparency and accountability of governments, enhanced citizen engagement and participation, improved service delivery, economic development and the stimulation of innovation. In part, these goals are to be achieved by making more and more government information public in reusable formats and under open licences. This paper identifies three broad privacy challenges raised by open government. The first is how to bala...

  14. Aggregating governance indicators

    Kaufmann, Daniel; Kraay, Aart; Zoido-Lobaton, Pablo

    1999-01-01

    In recent years the growing interest of academics and policymakers in governance has been reflected in the proliferation of cross-country indices measuring various aspects of governance. The authors explain how a simple variant of an unobserved components model can be used to combine the information from these different sources into aggregate governance indicators. The main advantage of this method us that it allows quantification of the precision of both individual sources of governance data...

  15. Governance and Development

    Khan, Mushtaq

    2006-01-01

    Governance matters are arguably at the core of international development. What role do theory, policy and practice play in shaping matters of governance with respect to development? This review paper, which is organised in three parts, focuses on this subject since the demise of communism in 1991. In the first part, the theories on the governance and development nexus are outlined. In the second, governance policy is discussed with reference to: the early strategic policy shift; the concepts,...

  16. THEORIES OF CORPORATE GOVERNANCE

    Sorin Nicolae BORLEA; Monica-Violeta ACHIM

    2013-01-01

    This study attempts to provide a theoretical framework for the corporate governance debate. The review of various corporate governance theories enhances the major objective of corporate governance which is maximizing the value for shareholders by ensuring good social and environment performances. The theories of corporate governance are rooted in agency theory with the theory of moral hazard’s implications, further developing within stewardship theory and stakeholder theory and evolving at re...

  17. Project governance: selected South African government experiments

    G. van der Walt

    2008-07-01

    Full Text Available Some form of accountability and power structure binds all organisations. Such structures are typically referred to as the “governance” structure of the organisation. In organisations that have relatively mature project applications and methodologies in place, governance mechanisms are established on more permanent bases. With its focus on performance, results and outcomes, project governance establishes decision-making structures, as well as accountability and responsibility mechanisms in public institutions to oversee projects. As government institutions increasingly place emphasis on project applications for policy implementation and service delivery initiatives, mechanisms or structures should be established to facilitate clear interfaces between the permanent organisation and the temporary project organisation. Such mechanisms or structures should enhance the governance of projects, that is, the strategic alignment of projects, the decentralisation of decision- making powers, rapid resource allocation, and the participation of external stakeholders. The purpose of this article is to explore the concept “project governance”, and to highlight examples of project governance as applied in selected government departments in provincial and national spheres. This would enable the establishment of best practice examples and assist to develop benchmarks for effective project applications for service delivery improvement.

  18. Foundations of Corporate Governance

    Volonté, Christophe

    2012-01-01

    This paper outlines the foundations of corporate governance. The discussion includes a review on the modern corporation, transaction costs theory, agency costs theory, legal investor protection, investor protection by corporate governance and its various mechanisms, as well as an overview of the determinants of corporate governance.

  19. Tourism and Governance

    Dredge, Dianne

    2015-01-01

    This chapter discusses tourism education for sustainability with a particular focus on the challenges and opportunities associated with preparing students to work within complex tourism governance settings. It takes the position that the development of tourism within a sustainability framework...... and contemporary knowledge and understandings of governance; competencies for tourism governance for sustainability; and ethical action-oriented practice....

  20. Jordan Corporate Governance Regulations

    Jordan Institute of Directors

    2013-01-01

    As the importance of Corporate Governance increases, an awareness and understanding of the different relevant regulations becomes of paramount value. The importance and value of Corporate Governance is not the core of this publication. The publication is built around the premise that Corporate Governance is important and increasingly becoming of significant importance for growth, continued...

  1. Governance Indicators for Development

    Charles Oman; Christiane Arndt

    2006-01-01

    The use of governance “indicators” is booming. These indicators are supposed to quantify the quality of a country’s governance institutions by considering, for example, the extent of corruption in the economy, the quality of public and private regulatory systems, the prevalence of “rule of law”, the level of political stability, and the effectiveness of government.

  2. Teaching about Comparative Government

    Risinger, C. Frederick

    2009-01-01

    As international relationships become increasingly important (with both friendly and not-so-friendly governments), the author believes that it is important for U.S. students to learn about how a parliamentary democracy works--how it is similar, but different from a presidential-style government. Learning about the systems of government of other…

  3. CORPORATE GOVERNANCE IN THE CURRENT CRISIS

    Emilia VASILE; Ion CROITORU

    2013-01-01

    Corporate governance is a set of functional processes and structures established by the leadership of the organization in order to inform, direct and monitor lead activities in order to achieve predetermined objectives. Efficient and effective corporate governance involves goals, long-term strategic plans, policies and implementation of the strategy, but also a proper leadership which sets the appropriate issue appropriate decisions to achieve the objectives and ensure the functioning of the ...

  4. Institutional Impacts of the Local Government Reform Program on Good Local Governance in Tanzania

    Boniface E.S. Mgonja

    2012-05-01

    Full Text Available Ever since the early 1990s, Tanzania’s government has embarked upon ambitious and far-reaching reform programs to improve the socioeconomic condition of the country. Among them was the development of anti-corruption strategies and the local government reform program. Overall, these reform programs were expected to improve good governance through reformed and autonomous local institutions. As such, this paper provides a detailed analysis of two reform initiatives, namely, anti-corruption strategies and LGRP based on their main policy goals as well as impacts on the overall institutional performance of local institutions in Tanzania. Drawing upon review of some empirical studies, the paper discusses what is seen as major structural concerns in the workings of these reforms in their entirety. This paper builds on the proposition that, unless someone addresses “institutional shortfalls” within the greater system of governance, any policy or reform initiative aimed at improving good governance will ultimately fail to deliver.

  5. MicroRNA-379-5p inhibits tumor invasion and metastasis by targeting FAK/AKT signaling in hepatocellular carcinoma.

    Chen, Jing-Song; Li, Hua-Shu; Huang, Jiong-Qiang; Dong, Shi-Hao; Huang, Zhi-Jie; Yi, Wei; Zhan, Gao-Fang; Feng, Ju-Tao; Sun, Jian-Cong; Huang, Xiao-Hui

    2016-05-28

    Some microRNAs (miRNAs) have been implicated in hepatocellular carcinoma (HCC) development and progression. However, the roles and mechanisms of several miRNAs in HCC remain poorly understood. Here, we report that miR-379-5p, which is down-regulated in HCC tissues and cell lines, is associated with advanced TNM stage and metastasis in HCC. The ectopic overexpression of miR-379-5p inhibited HCC cell migration, invasion, epithelial-to-mesenchymal transition (EMT) and metastasis both in vitro and in vivo. Conversely, miR-379 knockdown increased migration, invasion and EMT in HCC cells. Moreover, miR-379-5p exerted this function by directly targeting focal adhesion kinase (FAK) 3'-UTR and repressing FAK expression, thus leading to suppression of AKT signaling. Furthermore, the tumor suppressive effects of miR-379-5p in HCC cells were reversed by activating AKT signaling or restoring FAK expression. In clinical samples of HCC, miR-379-5p negatively correlated with FAK, which was up-regulated in HCC. Taken together, our findings highlight the important role of miR-379-5p in regulating the EMT and metastasis of HCC by targeting FAK/AKT signaling, suggesting that miR-379-5p may represent a novel potential therapeutic target and prognostic marker for HCC. PMID:26944318

  6. Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme

    Salito, Loredana; Sammito, Mariangela; Banelli, Barbara; Caltabiano, Rosario; Barbagallo, Giuseppe; Zappalà, Agata; Battaglia, Rosalia; Cirnigliaro, Matilde; Lanzafame, Salvatore; Vasquez, Enrico; Parenti, Rosalba; Cicirata, Federico; Di Pietro, Cinzia; Romani, Massimo; Purrello, Michele

    2016-01-01

    MiR-671-5p is encoded by a gene localized at 7q36.1, a region amplified in human glioblastoma multiforme (GBM), the most malignant brain cancer. To investigate whether expression of miR-671-5p were altered in GBM, we analyzed biopsies from a cohort of forty-five GBM patients and from five GBM cell lines. Our data show significant overexpression of miR-671-5p in both biopsies and cell lines. By exploiting specific miRNA mimics and inhibitors, we demonstrated that miR-671-5p overexpression significantly increases migration and to a less extent proliferation rates of GBM cells. Through a combined in silico and in vitro approach, we identified CDR1-AS, CDR1, VSNL1 as downstream miR-671-5p targets in GBM. Expression of these genes significantly decreased both in GBM biopsies and cell lines and negatively correlated with that of miR-671-5p. Based on our data, we propose that the axis miR-671-5p / CDR1-AS / CDR1 / VSNL1 is functionally altered in GBM cells and is involved in the modification of their biopathological profile. PMID:26683098

  7. Government responses in the age of big data:Reform, challenge and strategy%大数据时代的政府回应--变革、挑战与应对

    杨戴萍; 古小华; 欧阳彬

    2015-01-01

    Big data thinking and application has been penetrating into public management, bringing not only reforms of government responses but also new challenges for government and society. To improve government re-sponses, it is of necessity to build an innovative response mechanism that will make responses more initiative, di-versified and multi-channeled, by integrating big data thought into the concept, approach and decision-making of government responses, establishing the strategic status of big data, building data culture and regulating data use.%大数据思维和应用已经渗透到政府治理范畴中,为政府回应带来了多方面的变革,使得政府和社会面临诸多新的挑战。必须把大数据思维融入政府回应的理念向度、工作方式和决策思路中,确立大数据的战略地位,营造数据文化,规范数据使用,创新政府回应机制,加强政府回应的主动性,拓展政府回应的渠道,真正提升政府回应能力。

  8. 大数据时代的政府回应--变革、挑战与应对%Government responses in the age of big data:Reform, challenge and strategy

    杨戴萍; 古小华; 欧阳彬

    2015-01-01

    Big data thinking and application has been penetrating into public management, bringing not only reforms of government responses but also new challenges for government and society. To improve government re-sponses, it is of necessity to build an innovative response mechanism that will make responses more initiative, di-versified and multi-channeled, by integrating big data thought into the concept, approach and decision-making of government responses, establishing the strategic status of big data, building data culture and regulating data use.%大数据思维和应用已经渗透到政府治理范畴中,为政府回应带来了多方面的变革,使得政府和社会面临诸多新的挑战。必须把大数据思维融入政府回应的理念向度、工作方式和决策思路中,确立大数据的战略地位,营造数据文化,规范数据使用,创新政府回应机制,加强政府回应的主动性,拓展政府回应的渠道,真正提升政府回应能力。

  9. Effects of miR-33a-5P on ABCA1/G1-mediated cholesterol efflux under inflammatory stress in THP-1 macrophages.

    Min Mao

    Full Text Available The present study is to investigate whether inflammatory cytokines inhibit ABCA1/ABCG1-mediated cholesterol efflux by regulating miR-33a-5P in THP-1 macrophages. We used interleukin-6 and tumor necrosis factor-alpha in the presence or absence of native low density lipoprotein (LDL to stimulate THP-1 macrophages. THP-1 macrophages were infected by either control lentivirus vectors or lentivirus encoding miR-33a-5P or antisense miR-33a-5P. The effects of inflammatory cytokines, miR-33a-5P and antisense miR-33a-5P on intracellular lipids accumulation and intracellular cholesterol contents were assessed by oil red O staining and quantitative intracellular cholesterol assay. ApoA-I-mediated cholesterol efflux was examined using the fluorescent sterol (BODIPY-cholesterol. The gene and protein expressions of the molecules involved in cholesterol trafficking were examined using quantitative real-time polymerase chain reaction and Western blotting. Inflammatory cytokines or miR-33a-5P increased intracellular lipid accumulation and decreased apoA-I-mediated cholesterol efflux via decreasing the expression of ABCA1 and ABCG1 in the absence or presence of LDL in THP-1 macrophages. However, antisense miR-33a-5P reversed the effects of inflammatory cytokines on intracellular lipid accumulation, cholesterol efflux, and the expression of miR-33a-5P, ABCA1 and ABCG1 in the absence or presence of LDL in THP-1 macrophages. This study indicated that inflammatory cytokines inhibited ABCA1/ABCG1-mediated cholesterol efflux by up-regulating miR-33a-5P in THP-1 macrophages.

  10. The SOX17/miR-371-5p/SOX2 axis inhibits EMT, stem cell properties and metastasis in colorectal cancer.

    Li, Yuling; Lv, Zhenbing; He, Guoyang; Wang, Jianmei; Zhang, Xiaojing; Lu, Guifeng; Ren, Xiaoli; Wang, Feifei; Zhu, Xiaohui; Ding, Yi; Liao, Wenting; Ding, Yanqing; Liang, Li

    2015-04-20

    Cancer stem cells (CSCs) and EMT-type cells, which share molecular characteristics with CSCs, have been believed to play critical roles in tumor metastasis. Although much progress has been garnered in elucidating the molecular pathways that trigger EMT, stemness and metastasis, a number of key mechanistic gaps remain elusive. In the study, miR-371-5p was obviously down-regulated in primary CRC tissues compared with matched adjacent normal mucosa and correlated significantly with differentiation, tumor size, lymphatic and liver metastases. MiR-371-5p could attenuate proliferation, invasion in vitro and metastasis in vivo in CRC cells. It also suppressed EMT by regulating Wnt/β-catenin signaling and strongly decreased the CRC stemness phenotypes. Moreover, demethylation of SOX17 induced miR-371-5p expression and consequently suppressed its direct target SOX2 in CRC cells. MiR-371-5p was necessary for SOX17 mediated cancer-related traits and SOX2 was a functional target of miR-371-5p. A positive relationship between SOX17 and miR-371-5p expression and a negative one between miR-371-5p and SOX2 expression were observed in CRC cell lines and tissues. In conclusion, we identified miR-371-5p as an important "oncosuppressor" in CRC progression and elucidated a novel mechanism of the SOX17/miR-371-5p/SOX2 axis in the regulation of EMT, stemness and metastasis, which may be a potential therapeutic target. PMID:25868860

  11. Long noncoding RNA H19 contributes to gallbladder cancer cell proliferation by modulated miR-194-5p targeting AKT2.

    Wang, Shou-Hua; Wu, Xiao-Cai; Zhang, Ming-Di; Weng, Ming-Zhe; Zhou, Di; Quan, Zhi-Wei

    2016-07-01

    Gallbladder cancer (GBC) is a highly malignant cancer with poor prognosis. Although long noncoding RNA (lncRNA) H19 has been reported to play vital role in many human cancers, whether it is involved in GBC proliferation is still unknown. This study was designed to explore the effect of H19 in GBC cell proliferation. The expression of H19 and AKT2 were significantly elevated in GBC tissues, and the level of miR-194-5p is markedly decreased. Moreover, the RNA levels of H19 and AKT2 were positively correlated, and H19 elevation was significantly associated with tumor size. Cell proliferation decreased significantly after knockdown of H19 in GBC-SD and NOZ cells and after knockdown of AKT2 in NOZ cells. Results from cell cycle studies indicated that the S phase were significantly decreased after knockdown of H19 in NOZ cells but significantly elevated after overexpression of H19 in GBC-SD cells. Furthermore, knockdown of H19 upregulated miR-194-5p levels, yet significantly decreased miR-194-5p targeting AKT2 gene expression in NOZ cells. Inhibitor against miR-194-5p reversed these effects. In addition, overexpression of H19 in GBC-SD cells downregulated miR-194-5p and markedly increased AKT2 expression, and miR-194-5p mimic reversed these effects. Eventually, GBC cells were arrested in G0/G1-phase after H19 knockdown, inhibition of miR-194-5p markedly promoted cells into S-phase and co-transfection of siH19, and miR-194-5p inhibitor exerted mutually counter-regulated effects on cell cycle. These results suggested that H19/miR-194-5p/AKT2 axis regulatory network might modulate cell proliferation in GBC. PMID:26803515

  12. Protein kinase C (PKC) phosphorylates human platelet inositol trisphosphate 5/sup +/-/-phosphomonoesterase (IP3 5'-p'tase) increasing phosphatase activity

    Phosphoinositide breakdown in response to thrombin stimulation of human platelets generates messenger molecules that activate PKC (diglyceride) and mobilize Ca++ (inositol tris-phosphates). The water soluble products of phospholipase C-mediated metabolism of phosphatidylinositol 4,5-diphosphate are inositol 1,4,5 P3 (IP3) and inositol 1:2-cyclic 4,5 P3 (cIP3). A specific phosphatase, IP3 5'-p'tase, cleaves the 5 phosphate from IP3 or cIP3 to form IP2 or cIP2 and P/sub i/, none of which mobilizes Ca++. Thus, the IP3 5'-p'tase may regulate cellular responses to IP3 or cIP3. The authors find that IP3 5'-p'tase isolated from human platelets is phosphorylated by rat brain PKC, resulting in a 4-fold increase in IP3 5'-p'tase activity. The authors phosphorylated IP3 5'-p'tase using γ 32P-ATP and found that the labeled enzyme comigrated on SDS-PAGE with the previously described 40K protein phosphorylated in response to thrombin stimulation of platelets. The similarity of the PKC-phosphorylated IP3 5'-p'tase observed in vitro and the thrombin-stimulated phosphorylated 40K protein known to be phosphorylated by PKC in vivo, suggests that these proteins may be the same. These results suggest that platelet Ca++ mobilization maybe regulated by PKC phosphorylation of the IP3 5'-p'tase and can explain the observation that phorbol ester treatment of intact human platelets results in decreased production of IP3 and decreased Ca++ mobilization upon subsequent thrombin addition

  13. Tumor suppressor miR-149-5p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma.

    Jin, Lu; Li, Yifan; Liu, Jiaju; Yang, Shangqi; Gui, Yaoting; Mao, Xiangming; Nie, Guohui; Lai, Yongqing

    2016-06-01

    Several studies have recently explored the role of microRNAs (miRNAs, miRs) in the tumorigenesis of various types of cancer. miRNAs have been reported to be involved in numerous cell processes, including cell apoptosis, proliferation and migration, thus suggesting that miRNAs may have an important role in cancer progression. Downregulation of miR-149-5p has been detected in RCC tissues by microarray profiling; however, its expression and function in RCC has yet to be elucidated. In the present study, reverse transcription‑quantitative polymerase chain reaction was performed to detect the expression levels of miR‑149‑5p in RCC tissues and paired normal tissues. In order to determine whether miR-149-5p was able to regulate cell proliferation, apoptosis or migration, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, flow cytometric and wound healing assays were conducted. The results demonstrated that miR‑149‑5p was significantly downregulated in RCC tissues compared with in normal tissues (P<0.05). The restoration of miR-149-5p expression using synthetic mimics suppressed cell proliferation and migration, and promoted cell apoptosis. These results indicated that miR‑149‑5p may act as a tumor suppressor in RCC. The present study is the first, to the best of our knowledge, to identify miR‑149‑5p as a tumor suppressor in RCC. Future studies will be focused on the potential role of miR‑149‑5p as a biomarker for the early detection and prognostic prediction of RCC, and as a therapeutic target in RCC. In addition, further exploration regarding the pathways underlying the effects of miR‑149‑5p in RCC is required. PMID:27121091

  14. Clinical significance of miR-140-5p and miR-193b expression in patients with breast cancer and relationship to IGFBP5

    Gökçe Güllü

    2015-03-01

    Full Text Available The functional role of IGFBP5 in breast cancer is complicated. Experimental and bioinformatics studies have shown that IGFBP5 is targeted by miR-140-5p and miR-193b, although this has not yet been proven in clinical samples. The aim of this study was to evaluate the expression of miR-140-5p and miR-193b in breast cancer and adjacent normal tissue and assess its correlation with IGFBP5 and the clinicopathological characteristics of the tumors. IGFBP5 protein expression was analyzed immunohistochemically and IGFBP5, miR-140 and miR-193b mRNA expression levels were analyzed with real-time RT-PCR. Tumor tissue had higher miR-140-5p expression than adjacent normal tissue (p = 0.015. Samples with no immunohistochemical staining for IGFBP5 showed increased miR-140-5p expression (p = 0.009. miR-140-5p expression was elevated in invasive ductal carcinomas (p = 0.002, whereas basal-like tumors had decreased expression of miR-140-5p compared to other tumors (p = 0.008. Lymph node-positive samples showed an approximately 13-fold increase in miR-140-5p expression compared to lymph node-negative tissue (p = 0.049. These findings suggest that miR-140-5p, but not miR-193b, could be an important determinant of IGFBP5 expression and clinical phenotype in breast cancer patients. Further studies are needed to clarify the expressional regulation of IGFBP5 by miR-140-5p.

  15. Governing To‐day

    Turner, Kevin

    Governing To-day denotes a domain of research, and what the thesis undertakes is a theoretical discussion of some questions of method vis-à-vis researching this domain. There are two aspects to the title that enfold one another. Firstly, “governing to-day” signposts that it is to!day that is to be...... governed, that it is ourselves in our actuality that form the target of government, hence it is this government of ourselves in our present that we are to enquire into. Secondly, “governing to-day” highlights the fact that it is thus the state of contemporary arts of government, government at this moment...... in time, in the present!day, in this time that is our own, and so forth, that forms the object of enquiry. Accordingly, “governing to!day” denotes both a government of the present and government in the present. In working through said questions of method, the thesis sketches out an approach that...

  16. Trust and governance in regional planning

    Tait, Malcolm; Hansen, Carsten Jahn

    2013-01-01

    This paper seeks to understand how planning systems respond to narratives of distrust, focusing on regional planning as a particularly contested field. Using a framework to explore how reforms have enhanced trust, analysis of cases in England and Denmark reveals two distinct actions: firstly, a r...... form of government....... reliance on strengthening formal mechanisms of government, a feature common in England, and secondly, collaborative governance, as seen in Denmark. However, both strategies fail to adequately enhance trust in the values of regional planning, leaving it vulnerable to ideological critique as a worthwhile...

  17. Hard and Soft Governance

    Moos, Lejf

    2009-01-01

    The governance and leadership at transnational, national and school level seem to be converging into a number of isomorphic forms as we see a tendency towards substituting 'hard' forms of governance, that are legally binding, with 'soft' forms based on persuasion and advice. This article analyses...... and discusses governance forms at several levels. The first layer is the global: the methods of 'soft governance' that are being utilised by transnational agencies. The second layer is the national and local: the shift in national and local governance seen in many countries, but here demonstrated in...... the case of Denmark, and finally the third layer: the leadership used in Danish schools. The use of 'soft governance' is shifting the focus of governance and leadership from decisions towards influence and power and thus shifting the focus of the processes from the decision-making itself towards more...

  18. Plasma Levels of hsa-miR-619-5p and hsa-miR-1184 Differ in Prostatic Benign Hyperplasia and Cancer.

    Knyazev, E N; Fomicheva, K A; Mikhailenko, D S; Nyushko, K M; Samatov, T R; Alekseev, B Ya; Shkurnikov, M Yu

    2016-05-01

    Peripheral blood plasma profiles of circulating microRNA expression were analyzed in patients with prostatic cancer and benign hyperplasia. In prostatic cancer, significant increase in hsa-miR-619-5p and hsa-miR-1184 microRNA expression and significant decrease in hsalet-7b-5p and hsa-let-7c-5p microRNA expression were observed. The role of the relationship between the microRNA expression and the activities and functions of host genes with introns encoding these microRNA is discussed. PMID:27265125

  19. The 5s25p 2P-5s5p24P intercombination lines in the In I isoelectronic sequence from Sb III to La IX

    The 5s25p2P-5s5p24P intercombination lines in indium-like ions have been identified from Sb III to La IX. For Sb III and Te IV previously reported values are confirmed and for I V, the 5s5p24P3/2 level has been revised while all other 5s5p24P levels for all spectra have been reported for the first time. Thirty-three lines are classified, of which 20 are new. (author)

  20. Role of MiR-3619-5p in β-Catenin-Mediated Non-Small Cell Lung Cancer Growth and Invasion

    Xuecai Niu

    2015-10-01

    Full Text Available Background/Aims: The malignancy of non-small cell lung cancer (NSCLC is largely due to its fast growth and invasion. WNT/β-catenin signaling plays a critical role in regulating NSCLC carcinogenesis. Hence, suppression of β-catenin signal transduction in NSCLC cells may improve the therapeutic outcome. Methods: We analyzed the levels of β-catenin and miR-3619-5p in NSCLC specimens, compared to paired non-tumor normal lung tissue (NT. We did Bioinformatics analyses on the binding sites of 3'-UTR of β-catenin mRNA by miR-3619-5p. We modified the levels of miR-3619-5p in NSCLC cells and examined their effects on β-catenin levels, and on the growth and invasion of NSCLC cells in an MTT assay and a transwell cell migration assay, respectively. Results: NSCLC specimens had significant higher levels of β-catenin, and significantly lower levels of miR-3619-5p, compared to NT. The levels of β-catenin and miR-3619-5p were inversely correlated in NSCLC specimens. Bioinformatics analyses showed that miR-3619-5p bound to 3'-UTR of β-catenin mRNA in NSCLC cells to inhibit its translation. Overexpression of miR-3619-5p decreased β-catenin protein, while depletion of miR-3619-5p increased β-catenin protein in NSCLC cells, without altering β-catenin mRNA levels. Overexpression of miR-3619-5p in NSCLC cells inhibited cell growth and invasion, while depletion of miR-3619-5p in NSCLC lines increased cell growth and invasion. Conclusion: Our data demonstrate a previously unappreciated role for miR-3619-5p in suppression of β-catenin-mediated cancer growth and invasion in NSCLC cells, and highlight miR-3619-5p as a novel cancer suppressor in NSCLC.

  1. Formalizing a Debt Management Strategy

    Magnusson, Tomas I.

    2005-01-01

    In short, central government debt management can be defined as the process of establishing and executing a strategy in order to meet the debt management objectives. Undoubtedly, the development of the strategy is the most important debt management decision. Given the market constraints, it is the strategy document that decides on issues such as the level of exposure to foreign currency ris...

  2. Governance or Governing – the Missing Link?

    Luminiţa Maria Crăciun

    2010-07-01

    Full Text Available Governance and governing are two distinct concepts, but they intertwine. “Good governing” exercises good influence on development. “Good governance” supposes first a relationship of power focused on a series of reforms structured at three levels: the political – administrative level, the economic level, and the level of civil society. As this dimension is difficult to measure, the qualitative evaluation of the governing act raised the interest of the World Bank researchers, who elaborated and monitored the dynamics of a set of indicators, which includes six major dimensions of the governing. A retrospective concerning the image of governing in Romania during the period from 1996 to 2005 suggests a modest increase of the score: from -0.138 (1996 to 0.008 (2002; that was partially achieved based on the voice and responsibility index and on the political stability index, not on those that measure more directly the administrative performance or the integrity of the governing act. For a comparative study, we chose seven countries for the purposes of analysis (two new European Union member states: Romania and Bulgaria; two older member countries of the European Union: Slovenia and Latvia; three non-member states: Moldova, Ukraine, and Georgia, which reveal the quality of the governing from a comparative perspective. Corruption control completes the image created by the analyzed indicators. The mere formal accomplishment of commitments made in the pre-accession activity, doubled by recent internal evolutions, bring doubts about the credibility of the anticorruption reforms, as Romania continues to be considered the country with the highest CPI in the European Union. The pessimism of public opinion and the fact that only 34% of the Romanian people consider that the level of corruption will decrease in the following three years constitutes an alarm signal addressed to the governance, in view of the real reformation of the administration system

  3. Inactivation of Escherichia coli glycerol kinase by 5'-[p-(fluorosulfonyl)benzoyl]adenosine: protection by the hydrolyzed reagent

    Incubation of Escherichia coli glycerol kinase with 5'-[p-(fluorosulfonyl)benzoyl]adenosine (FSO2BzAdo) at pH 8.0 and 250C results in the loss of enzyme activity, which is not restored by the addition of β-mercaptoethanol or dithiothreitol. The FSO2BzAdo concentration dependence of the inactivation kinetics is described by a mechanism that includes the equilibrium binding of the reagent to the enzyme prior to a first-order inactivation reaction in addition to effects of reagent hydrolysis. The hydrolysis of the reagent has two effects on the observed kinetics. The first effect is deviation from pseudo-first-order kinetic behavior due to depletion of the reagent. The second effect is the novel protection of the enzyme from inactivation due to binding of the sulfonate hydrolysis product. Determinations of the reaction stoichiometry with 3H-labeled FSO2BzAdo show that the inactivation is associated with the covalent incorporation of 1.08 mol of reagent/mol of enzyme subunit. Ligand protection experiments show that ATP, AMP, dAMP, NADH, 5'-adenylyl imidodiphosphate, and the sulfonate hydrolysis product of FSO2BzAdo provide protection from inactivation. The protection obtained with ATMP is not dependent on Mg2+. The results are consistent with modification by FSO2BzAdo of a single adenine nucleotide binding site per enzyme subunit

  4. SOX9 regulates microRNA miR-202-5p/3p expression during mouse testis differentiation

    Wainwright, Elanor N; Jorgensen, Joan S; Kim, Youngha; Truong, Vy; Bagheri-Fam, Stefan; Davidson, Tara; Svingen, Terje; Fernandez-Valverde, Selene L; McClelland, Kathryn S; Taft, Ryan J; Harley, Vincent R; Koopman, Peter; Wilhelm, Dagmar

    2013-01-01

    differentiation. These microRNAs are expressed in a sexually dimorphic pattern as the primordial XY gonad differentiates into a testis, with strong expression in Sertoli cells. In vivo, ectopic expression of pri-miR-202 in XX gonads did not result in molecular changes to the ovarian determination pathway...... promoter that is sufficient to drive expression in XY but not XX fetal gonads ex vivo. Mutation of SOX9 and SF1 binding sites reduced ex vivo transactivation of the pri-miR-202 promoter, demonstrating that pri-miR-202 may be a direct transcriptional target of SOX9/SF1 during testis differentiation. Our....... Expression of the primary transcript of miR-202-5p/3p remained low in XY gonads in a conditional Sox9-null mouse model, suggesting that pri-miR-202 transcription is downstream of SOX9, a transcription factor that is both necessary and sufficient for male sex determination. We identified the pri-miR-202...

  5. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.

    Chuang, H H; Prescott, E D; Kong, H; Shields, S; Jordt, S E; Basbaum, A I; Chao, M V; Julius, D

    2001-06-21

    Tissue injury generates endogenous factors that heighten our sense of pain by increasing the response of sensory nerve endings to noxious stimuli. Bradykinin and nerve growth factor (NGF) are two such pro-algesic agents that activate G-protein-coupled (BK2) and tyrosine kinase (TrkA) receptors, respectively, to stimulate phospholipase C (PLC) signalling pathways in primary afferent neurons. How these actions produce sensitization to physical or chemical stimuli has not been elucidated at the molecular level. Here, we show that bradykinin- or NGF-mediated potentiation of thermal sensitivity in vivo requires expression of VR1, a heat-activated ion channel on sensory neurons. Diminution of plasma membrane phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) levels through antibody sequestration or PLC-mediated hydrolysis mimics the potentiating effects of bradykinin or NGF at the cellular level. Moreover, recruitment of PLC-gamma to TrkA is essential for NGF-mediated potentiation of channel activity, and biochemical studies suggest that VR1 associates with this complex. These studies delineate a biochemical mechanism through which bradykinin and NGF produce hypersensitivity and might explain how the activation of PLC signalling systems regulates other members of the TRP channel family. PMID:11418861

  6. "Mobile USPTO Strategy"Tracking--Is US Federal Government in the Transition to the Mobile Internet ?%“移动USPTO战略”跟踪*--美国联邦政府在向移动互联网转型吗?

    中国高技术产业发展促进会知识产权战略研究课题组

    2015-01-01

    Now is big transition period of the American society for the"mobile Internet". There are a lot of development changes in their respective ifelds.The new laws,new policies and new plans which released by the federal government can be described as"numberless as the sand".But the federal government to the reform of mobile Internet transformation on the development of the information industry has a positive role in promoting.We should pay great importance on the Internet strategy of the United States.We should be clear to"iflter"out of the"landmark"document which may affect the process of United States , providing mirroring for the industrial development of China.

  7. Master spreadsheet for visual censusing corals by maximum diameter size class at Site Number ROS-5P on 2/20/2002

    US Fish and Wildlife Service, Department of the Interior — This spreadsheet summarizes the number of corals photographed along a permanent transect line at Underwater Site ROS-5P at Rose Atoll on 2/20/2002.

  8. Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell

    Xu, Ning; Zhang, Jianjun; Shen, Conghuan; Luo, Yi; Xia, Lei; Xue, Feng [Department of Transplantation and Hepatic Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, People' s Republic of China (China); Xia, Qiang, E-mail: xiaqiang1@yahoo.com.cn [Department of Transplantation and Hepatic Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, People' s Republic of China (China)

    2012-07-13

    Highlights: Black-Right-Pointing-Pointer miR-199a-5p levels were significantly decreased after cisplatin treatment. Black-Right-Pointing-Pointer Cisplatin treatment induced autophagy activation. Black-Right-Pointing-Pointer Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell. -- Abstract: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Systemic chemotherapy plays an important role in the treatment of patients with advanced liver cancer. However, chemoresistance to cisplatin is a major limitation of cisplatin-based chemotherapy in the clinic, and the underlying mechanism of such resistance is not fully understood. In the study, we found that miR-199a-5p levels were significantly reduced in HCC patients treated with cisplatin-based chemotherapy. Cisplatin treatment also resulted in decreased miR-199a-5p levels in human HCC cell lines. Forced expression of miR-199a-5p promoted cisplatin-induced inhibition of cell proliferation. Cisplatin treatment activated autophagy in Huh7 and HepG2 cells, which increased cell proliferation. We further demonstrated that downregulated miR-199a-5p enhanced autophagy activation by targeting autophagy-associated gene 7 (ATG7). More important, autophagy inhibition abrogated miR-199a-5p downregulation-induced cell proliferation. These data demonstrated that miR-199a-5p/autophagy signaling represents a novel pathway regulating chemoresistance, thus offering a new target for chemotherapy of HCC.

  9. Specific residues of the GDP/GTP exchange factor Bud5p are involved in establishment of the cell type-specific budding pattern in yeast.

    Kang, Pil Jung; Lee, Bongyong; Park, Hay-Oak

    2004-07-01

    Cells of the budding yeast undergo oriented cell division by choosing a specific site for growth depending on their cell type. Haploid a and alpha cells bud in an axial pattern whereas diploid a/alpha cells bud in a bipolar pattern. The Ras-like GTPase Rsr1p/Bud1p, its GDP-GTP exchange factor Bud5p, and its GTPase-activating protein Bud2p are essential for selecting the proper site for polarized growth in all cell types. Here we showed that specific residues at the N terminus and the C terminus of Bud5p were important for bipolar budding, while some residues were involved in both axial and bipolar budding. These bipolar-specific mutations of BUD5 disrupted proper localization of Bud5p in diploid a/alpha cells without affecting Bud5p localization in haploid alpha cells. In contrast, Bud5p expressed in the bud5 mutants defective in both budding patterns failed to localize in all cell types. Thus, these results identify specific residues of Bud5p that are likely to be involved in direct interaction with spatial landmarks, which recruit Bud5p to the proper bud site. Finally, we found a new start codon of BUD5, which extends the open reading frame to 210 bp upstream of the previously estimated start site, thus encoding a polypeptide of 608 amino acid residues. Bud5p with these additional N-terminal residues interacted with Bud8p, a potential bipolar landmark, suggesting that the N-terminal region is necessary for recognition of the spatial cues. PMID:15136576

  10. Canada's medical isotope strategy

    This paper details Canada's medical isotope strategy and the role of the Canadian Government in the security of the isotope supply chain. The government's role is to promote health and safety of Canadians, establish appropriate regulatory framework, allow the markets to work, facilitate international collaboration, fund high-risk early stage research and development, encourage private sector investment in innovation and support and respect environmental and non-proliferation goals.

  11. Negotiating Collaborative Governance Designs

    Plotnikof, Mie

    2016-01-01

    governance designs emerge and change. The findings of a case study of local governments' efforts to innovate quality management in education through collaborative governance suggest that such form of governance is continuingly negotiated in communication during both design and implementation phases. Through......This article addresses the design and implementation issues of collaborative governance, a public-management practice aimed at involving stakeholders in problem solving and public innovation. Although aspects of for example stakeholder inclusion and power are conceptualized in the literature, these...... issues remain challenging in practice. Therefore, the interest in understanding the emerging processes of collaborative governance is growing. This article contributes to theorizing discursive aspects of such processes by conceptualizing and exploring the meaning negotiations through which collaborative...

  12. Transnational Governance and Constitutionalism

    Joerges, Christian; Sand, Inger-Johanne; Teubner, Gunther

    challenging the type of governance which constitutional states were supposed to represent and ensure. They also provoke old questions: Who bears the responsibility for governance without a government? Can accountability be ensured? The term 'constitutionalism' is still widely identified with statal form of......The term transnational governance designates untraditional types of international and regional collaboration among both public and private actors. These legally-structured or less formal arrangements link economic, scientific and technological spheres with political and legal processes. They are...... democratic governance. The book refers to this term as a yardstick to which then contributors feel committed even where they plead for a reconceptualisation of constitutionalism or a discussion of its functional equivalents. 'Transnational governance' is neither public nor private, nor purely international...

  13. Ethics and Water Governance

    David Groenfeldt

    2013-03-01

    Full Text Available Ethics and values are important dimensions of water governance. We show how a "values approach" contributes to an understanding of global water governance, and how it complements other perspectives on governance, namely management, institutional capacity, and social-ecological systems. We connect these other approaches to their own value systems and the ethical attitudes they engender. We then offer a way to explicitly incorporate, and where necessary adjudicate, competing value systems through a values-based approach to governance. A case of the Santa Fe River in New Mexico, USA illustrates how value systems are reflected in water policies and how these values affect governance priorities, such as in environmental flows. The values-based approach clarifies tacit values and creates space to align local values with those needed for effective water governance at the global level.

  14. MicroRNA-674-5p/5-LO axis involved in autoimmune reaction of Concanavalin A-induced acute mouse liver injury.

    Su, Kunkai; Wang, Qi; Qi, Luoyang; Hua, Dasong; Tao, Jingjing; Mangan, Connor J; Lou, Yijia; Li, Lanjuan

    2016-09-01

    Autoimmune hepatitis is characterized, in part, by the pathways involving cysteinyl-leukotriene metabolites of arachidonic acid, the dynamics of which remain unclear. Here, we explored post-transcriptional regulation in the 5-lipoxygenase (5-LO) pathway of arachidonic acid in a Concanavalin A (Con A) induced mouse model. We found that Con A administration lead to 5-LO overexpression and cysteinyl-leukotriene release in early hepatic injury, which was attenuated by cyclosporin A pretreatment. Subsequent microarray and qRT-PCR analysis further showed that microRNA-674-5p (miR-674-5p) displayed a significant decrease in expression in Con A-damaged liver. Noting that miR-674-5p harbors a potential binding region for 5-LO, we further transfected hepatic cell lines with overexpressing miR-674-5p mimic and discovered a negative regulating effect of miR-674-5p on 5-LO expression in the presence of IL-6 or TNF-α. These findings suggest that miR-674-5p might be a negative regulator in 5-LO mediated autoimmune liver injury, representing a compelling avenue towards future therapeutic interventions. PMID:27313091

  15. Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation

    Cao, Bo; Wang, Kebing; Liao, Jun-Ming; Zhou, Xiang; Liao, Peng; Zeng, Shelya X; He, Meifang; Chen, Lianzhou; He, Yulong; Li, Wen; Lu, Hua

    2016-01-01

    Increasing evidence highlights the important roles of microRNAs in mediating p53’s tumor suppression functions. Here, we report miR-139-5p as another new p53 microRNA target. p53 induced the transcription of miR-139-5p, which in turn suppressed the protein levels of phosphodiesterase 4D (PDE4D), an oncogenic protein involved in multiple tumor promoting processes. Knockdown of p53 reversed these effects. Also, overexpression of miR-139-5p decreased PDE4D levels and increased cellular cAMP levels, leading to BIM-mediated cell growth arrest. Furthermore, our analysis of human colorectal tumor specimens revealed significant inverse correlation between the expression of miR-139-5p and that of PDE4D. Finally, overexpression of miR-139-5p suppressed the growth of xenograft tumors, accompanied by decrease in PDE4D and increase in BIM. These results demonstrate that p53 inactivates oncogenic PDE4D by inducing the expression of miR-139-5p. DOI: http://dx.doi.org/10.7554/eLife.15978.001 PMID:27383270

  16. Monocyte to macrophage differentiation-associated (MMD) targeted by miR-140-5p regulates tumor growth in non-small cell lung cancer

    Li, Weina, E-mail: liweina228@163.com [Department of Biomedical Engineering, Fourth Military Medical University, Xi’an 710032 (China); He, Fei, E-mail: hesili1027@163.com [Department of Hepatic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032 (China)

    2014-07-18

    Highlights: • Expression of MMD is increased in lung cancer tissues. • Knockdown of MMD inhibits growth of A549 and LLC cells in vitro and in vivo. • MMD is a direct functional target of miR-140-5p. • MiR-140-5p/MMD axis regulates Erk1/2 signaling. - Abstract: Monocyte to macrophage differentiation-associated (MMD) is identified in macrophages as a gene associated with the differentiation from monocytes to macrophages. Recent microarray analysis for non-small cell lung cancer (NSCLC) suggests that MMD is an important signature associated with relapse and survival among patients with NSCLC. Therefore, we speculate that MMD likely plays a role in lung cancer. In this study, we found that the protein level of MMD was increased in lung cancer compared to benign lung tissues, and knockdown of MMD inhibited the growth of A549 and Lewis lung cancer cells (LLC) in vitro and in vivo. Integrated analysis demonstrated that MMD was a direct functional target of miR-140-5p. Furthermore, we found that miR-140-5p/MMD axis could affect the cell proliferation of lung cancer cells by regulating Erk signaling. Together, our results highlight the significance of miR-140-5p/MMD axis in lung cancer, and miR-140-5p/MMD axis could serve as new molecular targets for the therapy against lung cancer.

  17. Inverse correlation of expression of microRNA-140-5p with progression of multiple sclerosis and differentiation of encephalitogenic T helper type 1 cells.

    Guan, Hongbing; Singh, Udai P; Rao, Roshni; Mrelashvili, Davit; Sen, Souvik; Hao, Haiping; Zumbrun, Elizabeth E; Singh, Narendra P; Nagarkatti, Prakash S; Nagarkatti, Mitzi

    2016-04-01

    The role of microRNA in the regulation of encephalitogenic T-cell development is of interest in understanding the pathogenesis of multiple sclerosis (MS). Direct binding of microRNAs to their target mRNAs usually suppresses gene expression and facilitates mRNA degradation. In this study, we observed that the expression of several microRNAs was significantly altered in patients with MS. Interestingly, the expression of miR-140-5p, among other microRNAs, was significantly decreased in the peripheral blood mononuclear cells of patients with MS, and this microRNA may regulate encephalitogenic T helper type 1 (Th1) cell differentiation. The expression level of miR-140-5p was inversely correlated with disease severity with greater reduction in relapsing disease compared with remitting disease. Transfection of synthetic miR-140-5p in peripheral blood mononuclear cells suppressed encephalitogenic Th1 differentiation. Signal transducer and activator of transcription 1 (STAT1) was the functional target of miR-140-5p - transfection of the synthetic miR-140-5p suppressed activation of STAT1 and the expression of its downstream target, T-bet. Our results suggested that miR-140-5p is probably involved in the regulation of encephalitogenic T cells in the pathogenesis of MS. PMID:26780721

  18. Monocyte to macrophage differentiation-associated (MMD) targeted by miR-140-5p regulates tumor growth in non-small cell lung cancer

    Highlights: • Expression of MMD is increased in lung cancer tissues. • Knockdown of MMD inhibits growth of A549 and LLC cells in vitro and in vivo. • MMD is a direct functional target of miR-140-5p. • MiR-140-5p/MMD axis regulates Erk1/2 signaling. - Abstract: Monocyte to macrophage differentiation-associated (MMD) is identified in macrophages as a gene associated with the differentiation from monocytes to macrophages. Recent microarray analysis for non-small cell lung cancer (NSCLC) suggests that MMD is an important signature associated with relapse and survival among patients with NSCLC. Therefore, we speculate that MMD likely plays a role in lung cancer. In this study, we found that the protein level of MMD was increased in lung cancer compared to benign lung tissues, and knockdown of MMD inhibited the growth of A549 and Lewis lung cancer cells (LLC) in vitro and in vivo. Integrated analysis demonstrated that MMD was a direct functional target of miR-140-5p. Furthermore, we found that miR-140-5p/MMD axis could affect the cell proliferation of lung cancer cells by regulating Erk signaling. Together, our results highlight the significance of miR-140-5p/MMD axis in lung cancer, and miR-140-5p/MMD axis could serve as new molecular targets for the therapy against lung cancer

  19. Civil Society and Governance

    Hulgård, Lars

    An illustration of how important the relationship is between civil society anbd governance. A short historic journey with four snapshots of times and situations that have provided interesting evidence about the connection between civil society and governance. My goal for the short historic journey...... is to make clear and hopefully even verify that providing knowledge about the impact of civil society and citizens’ participation on governance is one of the most urgent research tasks in the current period of time....

  20. Multistakeholder Internet Governance?

    Dutton, William H.

    2015-01-01

    Global debate over alternative approaches to governing the Internet has been wide ranging, but increasingly has pivoted around the wisdom of “multistakeholder governance.” This paper takes controversy around a multistakeholder versus an alternative multilateral approach as a focus for clarifying the changing context and significance of Internet governance. A critical perspective on this debate challenges some of the conventional wisdom marshaled around positions on the history ...

  1. Understanding Government Consumption

    Lenka V. Půlpánová

    2013-01-01

    Government fi nal consumption represents one of the key indicators provided by national accounts, but at thesame time one with relatively problematic economic interpretation. Th e concept of government fi nal consumptionexpenditure involves a number of conventions. As a result, its economic and statistical character diff ersfrom other fi nal expenditure components in total economy like household consumption or investment. Th earticle explains how government fi nal consumption expenditure and ...

  2. Exploring Knowledge Governance

    Foss, Nicolai Juul; Mahoney, Joseph T

    Knowledge governance is characterized as a distinctive research subject, the understanding of which cuts across diverse fields in management. In particular, it represents an intersection of knowledge management, strategic management, and theories of the firm. Knowledge governance considers how...... deployment of governance mechanisms influences knowledge processes: sharing, retaining, and creating knowledge. We survey the papers in this volume of the special issue, and discuss the remaining research challenges....

  3. Second generation governance indicators

    Knack, Stephen; Kugler, Mark; Manning, Nick

    2002-01-01

    This paper summarizes progress made in a DfID-funded World Bank initiative to test and develop policy-relevant, politically acceptable, quantitative indicators of governance. There are two major components involved in the process of generating indicators that are practical means of reform. Political acceptability is key in developing neutral quantitative benchmarks of good governance that can be embraced by reformers. In addition to political acceptability, measuring governance must be com...

  4. Measuring African Governance

    Hazel M. McFerson

    2009-01-01

    A profusion of governance measures has emerged over the past decade. The major issue is whether governance should be understood only by its attributes (thus measured by process indicators) or also by its impact (thus measured also by outcome indicators). The article classifies the existing measures in three categories—indicators of governance and corruption, measures of civil liberties and human rights, specialized surveys—and discusses in greater depth the two comprehensive surveys: the ...

  5. Macroeconomics and Governance

    Gordon de Brouwer

    2003-01-01

    In recent years there has been a resurgence of interest in the impact of institutions on economic growth and development. Governance, both at the economy-wide and firm-specific level, has emerged as one of the central aspects of institutional structure and design. The paper argues that the quality of governance matters to macroeconomic performance because it provides a key foundation for the equitable and efficient allocation of resources, including capital. Better governance tends to be asso...

  6. Corporate Governance and Control

    Patrick Bolton; Marco Becht; Alisa Röell

    2002-01-01

    Corporate governance is concerned with the resolution of collective action problems among dispersed investors and the reconciliation of conflicts of interest between various corporate claimholders. In this survey we review the theoretical and empirical research on the main mechanisms of corporate control, discuss the main legal and regulatory institutions in different countries, and examine the comparative corporate governance literature. A fundamental dilemma of corporate governance emerges ...

  7. Governance Issues for SMEs

    Thomas Clarke; Alice Klettner

    2014-01-01

    This paper draws on research into the corporate governance practices of small and medium enterprises (SMEs) listed on the Australian Securities Exchange. Interviews were conducted with the directors and/or company secretaries of 19 SMEs. The aim of the research was to explore not only SME corporate governance structures and processes but how SMEs had chosen to implement the Principles and the reasons for their choices. The paper addresses the issue of whether the ASX Corporate Governance Prin...

  8. Ethics and Water Governance

    David Groenfeldt; Jeremy J. Schmidt

    2013-01-01

    Ethics and values are important dimensions of water governance. We show how a "values approach" contributes to an understanding of global water governance, and how it complements other perspectives on governance, namely management, institutional capacity, and social-ecological systems. We connect these other approaches to their own value systems and the ethical attitudes they engender. We then offer a way to explicitly incorporate, and where necessary adjudicate, competing value systems throu...

  9. Governability in Contemporary Mexico

    Leonardo Curzio Gutiérrez

    1998-01-01

    Given the difficulties to establish a concept of governability and the frequent ideological usage of the term, it is much more operative to turn to the principle of governability, in the broad sense, which supports itself on five pillars: the political legitimacy of the government, the governmental efficiency to attend to the demands of society, the existence of shared social project, the agreement with the principle special interest groups, and international viability. The analysis of the st...

  10. Energy Efficiency Governance: Handbook

    NONE

    2010-07-01

    This handbook has been written to assist EE practitioners, government officials and stakeholders to establish effective EE governance structures for their country. The handbook provides readers with relevant information in an accessible format that will help develop comprehensive and effective governance mechanisms. For each of the specific topics dealt with (see Figure 1 in the Handbook), the IEA offers guidelines for addressing issues, or directs readers to examples of how such issues have been dealt with by specific countries.

  11. Construction Strategies of the Long-term Government Regulations Mechanism of Energy Saving and Emission Reduction in Shandong Province%山东省节能减排政府规制长效机制的构建策略

    韩慧健; 辛况; 陶续云

    2012-01-01

    自市场化改革以来,中国经济在获得快速增长的同时也付出了惨重的资源和环境代价。若要维持经济的可持续发展,需要对节能减排颁布实施对应的政府政策,特别是建立节能减排的政府规制长效机制。但目前尚未形成此长效机制,这是导致能源与环境问题不能得到很好解决的根源。因此,本文选择山东省作为典型地区进行节能减排的政府规制政策长效机制构建,首先探讨了进行节能减排规制的必要性;在此基础上借鉴国外节能减排规制实践经验,挖掘山东省节能减排规制取得的成绩与存在的问题;最终构建山东省节能减排规制的长效机制。%Since the market-oriented reforms,China’s access to rapid economic growth has been at the expense of resources and the environment.To maintain the sustainable development of economy,the government need to imply the corresponding policies on energy saving and emission reduction,especially the establishment of the long-term government regulation mechanism.However,this mechanism has not yet been established,which leads to the energy and environmental problems.Thus,this article chooses Shandong Province as the typical area to establish the long-term government regulation mechanism of energy saving and emission reduction.First,this article investigates the necessity of government regulations on energy saving and emission reduction.Based on the necessity mentioned above,we draw lessons from the foreign experience of energy saving and emission reduction regulations.Then,energy-saving and emission reduction regulation's achievements and existing problems in Shandong province are demonstrated.Finally,we construct the long-term government regulation mechanism of energy saving and emission reduction in Shandong Province.

  12. E-Government Partnerships Across Levels of Government

    Charbit, Claire; Michalun, Varinia

    2009-01-01

    E-government Partnerships across Levels of Government, is an overview of the challenges and approaches to creating a collaborative and cooperative partnership across levels of government for e-government development and implementation.

  13. 77 FR 18258 - Government-to-Government Telephonic Consultation Meetings

    2012-03-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR National Park Service Government-to-Government Telephonic Consultation Meetings AGENCY: National Park Service, Interior. SUMMARY: The National Park Service announces two telephonic government-...

  14. eGovernment

    Shadbolt, Nigel; O'Hara, Kieron; Salvadores, Manuel; Alani, Harith

    2011-01-01

    The use of the Semantic Web (SW) in e-government is reviewed. The challenges for the introduction of SW technology in e-government are surveyed from the point of view both of the SW as a new technology that has yet to reach its full potential, and of e-government as a complex digital application with many constraints, competing interests and drivers, and a large and heterogeneous user base of citizens. The spread of SW technology through e-government is reviewed, looking at a number of intern...

  15. HTR1A a novel type 1 diabetes susceptibility gene on chromosome 5p13-q13.

    Samina Asad

    Full Text Available BACKGROUND: We have previously performed a genome-wide linkage study in Scandinavian Type 1 diabetes (T1D families. In the Swedish families, we detected suggestive linkage (LOD≤2.2 to the chromosome 5p13-q13 region. The aim of our study was to investigate the linked region in search for possible T1D susceptibility genes. METHODOLOGY/PRINCIPAL FINDINGS: Microsatellites were genotyped in the Scandinavian families to fine-map the previously linked region. Further, SNPs were genotyped in Swedish and Danish families as well as Swedish sporadic cases. In the Swedish families we detected genome-wide significant linkage to the 5-hydroxytryptamine receptor 1A (HTR1A gene (LOD 3.98, p<9.8×10(-6. Markers tagging two separate genes; the ring finger protein 180 (RNF180 and HTR1A showed association to T1D in the Swedish and Danish families (p<0.002, p<0.001 respectively. The association was not confirmed in sporadic cases. Conditional analysis indicates that the primary association was to HTR1A. Quantitative PCR show that transcripts of both HTR1A and RNF180 are present in human islets of Langerhans. Moreover, immunohistochemical analysis confirmed the presence of the 5-HTR1A protein in isolated human islets of Langerhans as well as in sections of human pancreas. CONCLUSIONS: We have identified and confirmed the association of both HTR1A and RFN180, two genes in high linkage disequilibrium (LD to T1D in two separate family materials. As both HTR1A and RFN180 were expressed at the mRNA level and HTR1A as protein in human islets of Langerhans, we suggest that HTR1A may affect T1D susceptibility by modulating the initial autoimmune attack or either islet regeneration, insulin release, or both.

  16. 《榆林日报》时政新闻中的政府媒介形象塑造与改进策略%The Government Media Images’Shaping and Strategies of Improvement in the Political News’Coverage on Yulin Daily

    苏晓暹; 熊秋萍

    2016-01-01

    新闻媒体对政府媒介形象的塑造通过多种方式来实现,时政新闻因其特殊的政治性、权威性和规范性成为建构政府媒介形象的最佳选择。在塑造地方政府媒介形象的过程中,《榆林日报》时政新闻采取了多种策略,其新闻文本在写作上表现出高度的规范性,题材和视角上具有较强的民生化倾向,有利于塑造良好的榆林市政府媒介形象。从塑造政府媒介形象的角度出发,《榆林日报》还需在现有基础上作出改进。%News media shapes the government media image through a variety of ways. There are many special char-acteristics in the coverage of political news,such as political nature,authority and normalization,which makes it the best choice to construct the government media image. In the course of shaping the government media image, Yulin Daily has adopted a variety of strategies. The political news in this newspaper is written normatively and standardly. Its theme and viewpoint choice has a strong tendency to people’s livelihood. Those approaches help improve the Yulin government media image shaping. Some corresponding suggestions on their improvement are put forward ,which can become a reference for Yulin Daily to improve its credibility and preferably shape the Yulin gov-ernment media image.

  17. Measuring the democratic anchorage of governance networks

    Fotel, Trine; Sørensen, Eva; Torfing, Jacob

    model helps to assess the democratic performance of specific governance networks and to gain knowledge about the critical factors that determine their degree of democratic anchorage. Such knowledge is crucial for developing proactive strategies for enhancing the democratic performance of specific...

  18. The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response.

    E Douglas Robertson

    Full Text Available The molecular response to hypoxia is a critical cellular process implicated in cancer, and a target for drug development. The activity of the major player, HIF1α, is regulated at different levels by various factors, including the transcription factor ELK3. The molecular mechanisms of this intimate connection remain largely unknown. Whilst investigating global ELK3-chromatin interactions, we uncovered an unexpected connection that involves the microRNA hsa-miR-155-5p, a hypoxia-inducible oncomir that targets HIF1α. One of the ELK3 chromatin binding sites, detected by Chromatin Immuno-Precipitation Sequencing (ChIP-seq of normal Human Umbilical Vein Endothelial Cells (HUVEC, is located at the transcription start site of the MIR155HG genes that expresses hsa-miR-155-5p. We confirmed that ELK3 binds to this promoter by ChIP and quantitative polymerase chain reaction (QPCR. We showed that ELK3 and hsa-miR-155-5p form a double-negative regulatory loop, in that ELK3 depletion induced hsa-miR-155-5p expression and hsa-miR-155-5p expression decreased ELK3 expression at the RNA level through a conserved target sequence in its 3'-UTR. We further showed that the activities of hsa-miR-155-5p and ELK3 are functionally linked. Pathway analysis indicates that both factors are implicated in related processes, including cancer and angiogenesis. Hsa-miR-155-5p expression and ELK3 depletion have similar effects on expression of known ELK3 target genes, and on in-vitro angiogenesis and wound closure. Bioinformatic analysis of cancer RNA-seq data shows that hsa-miR-155-5p and ELK3 expression are significantly anti-correlated, as would be expected from hsa-miR-155-5p targeting ELK3 RNA. Finally, hypoxia (0% oxygen down-regulates ELK3 mRNA in a microRNA and hsa-miR-155-5p dependent manner. These results tie ELK3 into the hypoxia response pathway through an oncogenic microRNA and into a circuit implicated in the dynamics of the hypoxic response. This crosstalk could

  19. The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response.

    Robertson, E Douglas; Wasylyk, Christine; Ye, Tao; Jung, Alain C; Wasylyk, Bohdan

    2014-01-01

    The molecular response to hypoxia is a critical cellular process implicated in cancer, and a target for drug development. The activity of the major player, HIF1α, is regulated at different levels by various factors, including the transcription factor ELK3. The molecular mechanisms of this intimate connection remain largely unknown. Whilst investigating global ELK3-chromatin interactions, we uncovered an unexpected connection that involves the microRNA hsa-miR-155-5p, a hypoxia-inducible oncomir that targets HIF1α. One of the ELK3 chromatin binding sites, detected by Chromatin Immuno-Precipitation Sequencing (ChIP-seq) of normal Human Umbilical Vein Endothelial Cells (HUVEC), is located at the transcription start site of the MIR155HG genes that expresses hsa-miR-155-5p. We confirmed that ELK3 binds to this promoter by ChIP and quantitative polymerase chain reaction (QPCR). We showed that ELK3 and hsa-miR-155-5p form a double-negative regulatory loop, in that ELK3 depletion induced hsa-miR-155-5p expression and hsa-miR-155-5p expression decreased ELK3 expression at the RNA level through a conserved target sequence in its 3'-UTR. We further showed that the activities of hsa-miR-155-5p and ELK3 are functionally linked. Pathway analysis indicates that both factors are implicated in related processes, including cancer and angiogenesis. Hsa-miR-155-5p expression and ELK3 depletion have similar effects on expression of known ELK3 target genes, and on in-vitro angiogenesis and wound closure. Bioinformatic analysis of cancer RNA-seq data shows that hsa-miR-155-5p and ELK3 expression are significantly anti-correlated, as would be expected from hsa-miR-155-5p targeting ELK3 RNA. Finally, hypoxia (0% oxygen) down-regulates ELK3 mRNA in a microRNA and hsa-miR-155-5p dependent manner. These results tie ELK3 into the hypoxia response pathway through an oncogenic microRNA and into a circuit implicated in the dynamics of the hypoxic response. This crosstalk could be important for

  20. miR-106a-5p inhibits the proliferation and migration of astrocytoma cells and promotes apoptosis by targeting FASTK.

    Feng Zhi

    Full Text Available Astrocytomas are common malignant intracranial tumors that comprise the majority of adult primary central nervous system tumors. MicroRNAs (miRNAs are small, non-coding RNAs (20-24 nucleotides that post-transcriptionally modulate gene expression by negatively regulating the stability or translational efficiency of their target mRNAs. In our previous studies, we found that the downregulation of miR-106a-5p in astrocytomas is associated with poor prognosis. However, its specific gene target(s and underlying functional mechanism(s in astrocytomas remain unclear. In this study, we used mRNA microarray experiments to measure global mRNA expression in the presence of increased or decreased miR-106a-5p levels. We then performed bioinformatics analysis based on multiple target prediction algorithms to obtain candidate target genes that were further validated by computational predictions, western blot analysis, quantitative real-time PCR, and the luciferase reporter assay. Fas-activated serine/threonine kinase (FASTK was identified as a direct target of miR-106a-5p. In human astrocytomas, miR-106a-5p is downregulated and negatively associated with clinical staging, whereas FASTK is upregulated and positively associated with advanced clinical stages, at both the protein and mRNA levels. Furthermore, Kaplan-Meier analysis revealed that the reduced expression of miR-106a-5p or the increased expression of FASTK is significantly associated with poor survival outcome. These results further supported the finding that FASTK is a direct target gene of miR-106a-5p. Next, we explored the function of miR-106a-5p and FASTK during astrocytoma progression. Through gain-of-function and loss-of-function studies, we demonstrated that miR-106a-5p can significantly inhibit cell proliferation and migration and can promote cell apoptosis in vitro. The knockdown of FASTK induced similar effects on astrocytoma cells as those induced by the overexpression of miR-106a-5p. These

  1. Contemporary Approaches to Corporate Governance

    Petr Pirožek

    2007-01-01

    The description of contemporary application of Corporate Governance principles in Czech companies. The prezentation of Corporate Governance decision steps. The definition of Corporate Governance individual practices in Czech companies. Presentation of future system development of Corporate Governance in Czech companies.

  2. Coping Strategies of Public Opinion of Government Micro-blog Public Emergencies%政务微博突发公共事件舆情应对策略研究

    邹欢芳

    2011-01-01

    Micro-blog information dissemination superiority has been generally recognized by the community, various government agencies and officials have opened the micro-blog, making the "micro-blog asks government" has become one of the hot points and trends. Public emergency public opinion because of its complexity and sensitivity, as well as the rapid spread characteristics, let government micro-blog in response to public opinion crisis difficulties. In this paper, through the analysis of e-government micro-blog public emergency coping situation of public opinion, attempts to propose the micro-blog guide public opinion of the specific methods and measures, for the building of a harmonious society will play a positive role.%微博的信息传播优势已得到了社会的普遍认可,各级政府机构和官员纷纷开设政务微博,使得“微博问政”成为当前的热点和趋势。突发公共事件舆论因其复杂性、敏感性以及传播迅速等特点,让政务微博在应对舆情危机时困难重重。本文通过分析政务微博突发公共事件的舆情应对现状,试图提出微博舆论引导的具体方法和对策,对于构建和谐社会将起到积极的作用。

  3. A Research on Interaction Mechanism and Management Strategy of Government and Private Pension Institutions%政府与民办养老机构互动机理及管理策略研究

    柳键; 舒斯亮

    2013-01-01

    The paper constructs a game model between government and private pension institutions, to explore the relation-ship between pricing of private pension institutions and government's subsidy, the selection of the single-class service mode or the multi-class service model, then to analyze the influences of the related factors to government and private pension insti-tutions. The results show that: the private pension institutions should expand the gap of service level appropriately when the multi-class service mode is selected, the multi-class pension service mode is better than the single-class pension service mode when the pension demand level is higher, the single-class pension service mode is better than the multi-class pension service mode when the pension demand level is lower, the government and private pension institutions perform better with the multi-class pension service mode when service preference of senior people increases, the pension service institutions with higher cost should choose single-class pension service mode, while the pension service institutions with lower cost should select multi-class pension service mode.%文章通过建立民办养老机构与政府的博弈模型,探讨政府补贴与民办养老机构定价的关系,以及单层级服务与多层级服务选择问题,分析相关因素变化对政府与民办养老机构所带来的影响。结果表明,民办养老机构选择多层级模式时,应适当拉开服务水平层级差距;养老需求水平较高时,多层级模式优于单层级模式,养老需求水平较低时,单层级模式优于多层级模式;老年人的机构养老服务偏好越大,选择多层级模式对政府及民办养老机构越有利;高服务成本的养老机构宜选择单层级模式,低服务成本的养老机构宜选择多层级模式。

  4. 基于社会治理视角的公立医院社会评价策略及研究框架构建%Developing the social evaluation strategy and the study framework for public hospitals as seen from the social governance perspective

    王小合; 黄仙红; 李瑞; 赵红; 高建民; 郭清; 张亮

    2011-01-01

    社会治理是基于对社会管理过程中权力格局分析与判断,在政府、市场、社会与公民基本关系明确定位的前提下倡导的新型公共管理模式.社会评价是基于社会治理理论的一种有效实现载体和手段,由于其对公众利益和责任表达、解决突出社会矛盾问题具针对性和优越性,已得到普遍促进和应用.在基于社会治理理论开展公立医院管理改革情景分析的基础上,阐述了国内外社会治理及社会评价理论、内涵与进展,以及对相关社会领域社会评价治理路径及实践探索进行梳理分析,提出了在医疗服务管理领域探讨和开发其公立医院社会评价策略及研究框架构建,为探索建立公立医院社会管理制度以及政策制定提供依据.%Social governance is a novel form of public administration made based on the analysis and judgment for the power pattern in the course of social administration, a model advocated in the premise of a clearly positioned relationship among the government, marketplace, society and citizens.Social evaluation is an effective carrier and means leveraging the social governance theory, which has found extensive and outstanding use in such issues as expression of public interests and responsibilities,and in tackling sharp social problems. The authors called into play the scenario analysis based on public hospital management reforms with the social governance theory. In addition, they explored social governance at home and abroad as well as the theories, meaning and progress of social evaluation, and analyzed the pathways and probes in social evaluation and governance in the fields in question. On such basis, the paper proposed to explore and develop the social evaluation strategies and study framework for public hospitals in terms of healthcare management, aiming at building the social governance system and policies for public hospitals.

  5. Using IT Governance

    Brobst, Jan; Council, Chip

    2005-01-01

    The discussion in this article is intended to provide an examination of why top management, IT management, and internal auditors should be interested in IT governance. Some aspects of IT management will be described including implementation, auditing, availability, security, and alignment. One governance framework, COBIT, will be utilized as a…

  6. Government Information Policy.

    Dearstyne, Bruce W.; And Others

    1991-01-01

    Six articles discuss government information policy in context of technology and electronic records; policies on information resources management from OMB (Office of Management and Budget); state information resources, including Council of State Governments (CSG); state record laws and preservation of archival records; and management of electronic…

  7. Educational Governance in Denmark

    Moos, Lejf

    2014-01-01

    Denmark has entered global competition by expanding collaboration with European countries, which is profoundly impacting the public sector and school governance. Relations between the state and institutions are transforming from traditional democratic, public-sector models of governance into new forms characterized as corporate and market-driven…

  8. Policy Governance Revisited.

    Price, William J.

    2001-01-01

    An administrator trainer/former superintendent's experience suggests that corporate governance models don't fit the reality of school governance in many districts. Elected board members define their roles differently than their business counterparts and derive little or no monetary benefit from public service. The "new breed" resemble political…

  9. China and Global Governance

    Wang Zaibang

    2007-01-01

    To enhance global governance has become more urgent with rapid development of globalization in the post-Cold War years. China has benefited from the process of globalization and hence should make greater contribution to the global governance in the future.

  10. Nordic Corporate Governance Revisited

    Thomsen, Steen

    2016-01-01

    This paper reviews the key elements of the Nordic governance model, which include a distinct legal system, high governance ratings and low levels of corruption. Other characteristics include concentrated ownership, foundation ownership, semi two-tier board structures, employee representation and...

  11. Making Government Liquid

    du Gay, Paul; Millo, Yuval; Tuck, Penelope

    2012-01-01

    assemblage. We argue that understanding such assemblages-their emergence, activity, and, frequently, their failures-opens a window on analysing the nature of contemporary forms of financialised governance as a technosocial system. In so doing we suggest that the governance devices approach can off er a way...

  12. Privacy and Open Government

    Teresa Scassa

    2014-06-01

    Full Text Available The public-oriented goals of the open government movement promise increased transparency and accountability of governments, enhanced citizen engagement and participation, improved service delivery, economic development and the stimulation of innovation. In part, these goals are to be achieved by making more and more government information public in reusable formats and under open licences. This paper identifies three broad privacy challenges raised by open government. The first is how to balance privacy with transparency and accountability in the context of “public” personal information. The second challenge flows from the disruption of traditional approaches to privacy based on a collapse of the distinctions between public and private sector actors. The third challenge is that of the potential for open government data—even if anonymized—to contribute to the big data environment in which citizens and their activities are increasingly monitored and profiled.

  13. Governance of the future

    Galløe, Lotte Rannveig

    towards shaping the future implies an expansion of public governance in to dimensions: in both time and space. Based on an ethnographic interpretation of Foucault’s notion of power, I wish to unfold how the technology of the future is practiced within PMTO-group sessions.......In my presentation I will explore the concept, ‘technology of the future’, in public governance. Public governance within social services aims at changing the existing conditions for the marginalized citizens including children with special needs. I pose the question: what happens if public...... governance seek to chance the possible future conditions and targets the marginalized child’s relatives? Parent Management Training (PMTO) is studied as a technology of the future that expands and transforms governance. PMTO targets parents with aggressive and asocial children and aims to “create the parent...

  14. A new corporate governance

    Ion Bucur

    2015-12-01

    Full Text Available The issue of corporate governance has become increasingly important as globalisation has begun to accelerate and the economic and financial turmoil have intensified. Post-crisis context has imposed the need to expand the prospects for analysis over governance and companies, as well as the need to identify new ways of administration and resource management. From this perspective, the author aims to highlight the conditions, factors and events that have generated profound changes within the business environment, while the analysis is focusing on contemporary changes in the systems of corporate governance and economic mutations, especially in terms of the companies. The establishment of new governance rules is demanding a theoretical approach based on new methodological requirements which are needed to reform theoretical foundations and to promote creative and effective shapes and governance systems.

  15. Governance, Trust and Taxes

    Weihe, Guri; Joensen, E. Juanna Schröter

    This paper examines the role of social capital (trust) vis-à-vis the propensity of a country to be a tax haven. The empirical analysis corroborates that better governed countries have a higher ceteris paribus probability to be tax havens. However, social capital counteracts the effect of governance...... quality. This effect is so strong that the partial effect of governance quality is reversed for countries with the trust index in the top quartile – making these high trust countries less likely to be tax havens – even as governance quality is increased. Thus it is crucial to consider the interaction...... between institutions and social capital, since the same governance institutions have a different impact on the tax haven propensity for countries with different social capital....

  16. Energy Efficiency Governance

    NONE

    2010-07-01

    The purpose of this report is to help EE practitioners, government officials and stakeholders to establish the most effective EE governance structures, given their specific country context. It also aims to provide readers with relevant and accessible information to support the development of comprehensive and effective governance mechanisms. The International Energy Agency (IEA) conducted a global review of many elements of EE governance,including legal frameworks, institutional frameworks, funding mechanisms, co-ordination mechanisms and accountability arrangements, such as evaluation and oversight. The research tools included a survey of over 500 EE experts in 110 countries, follow-up interviews of over 120 experts in 27 countries and extensive desk study and literature searches on good EE governance.

  17. THEORIES OF CORPORATE GOVERNANCE

    Sorin Nicolae BORLEA

    2013-03-01

    Full Text Available This study attempts to provide a theoretical framework for the corporate governance debate. The review of various corporate governance theories enhances the major objective of corporate governance which is maximizing the value for shareholders by ensuring good social and environment performances. The theories of corporate governance are rooted in agency theory with the theory of moral hazard’s implications, further developing within stewardship theory and stakeholder theory and evolving at resource dependence theory, transaction cost theory and political theory. Later, to these theories was added ethics theory, information asymmetry theory or the theory of efficient markets. These theories are defined based on the causes and effects of variables such as: the configuration of the board of directors, audit committee, independence of managers, the role of top management and their social relations beyond the legal regulatory framework. Effective corporate governance requires applying a combination

  18. Urban transport, the environment and deliberative governance

    Hansen, Carsten Jahn

    2006-01-01

    range of deliberative and more interactive governance approaches have emerged. This article discusses the central role of interdependence and trust in such approaches, based on three cases, Aalborg (DK), Lund (S) and Groningen (NL), in which environmental objectives and strategies have materialized in......Today, actors in policy making and planning are often faced with demands of handling conditions characterized by increasing fragmentation, differentiation and complexity. In response to an apparent limited reach of traditional monocentric and top-down governing in dealing with those conditions, a...... in searching for new formats for collaboration and deliberative governance and, in particular, for generating trust among interdependent actors. The concluding remark holds that deliberative governance can illuminate conflicting relations and provoke or massage those early in policy and planning...

  19. MicroRNA-17-5p post-transcriptionally regulates p21 expression in irradiated betel quid chewing-related oral squamous cell carcinoma cells

    Wu, S.Y. [Taipei Medical Univ., Wan Fang Hospital, Taipei (China). Dept. of Radiation-Oncology; HungKuang Univ., Taichung (China). Dept. of Biotechnology; Lin, K.C. [Taipei Medical Univ., Wan Fang Hospital, Taipei (China). Dept. of Oral and Maxillofacial Surgery; Chiou, J.F. [Taipei Medical Univ., Taipei (China). Dept. of Radiology; Taipei Medical Univ. Hospital, Taipei (China). Dept. of Radiation Oncology; Taipei Medical Univ. Hospital, Taipei (China). Dept. of Hospice and Palliative Center; Taipei Medical Univ. Hospital, Taipei (China). Cancer Center; Jeng, S.C. [Taipei Medical Univ. Hospital, Taipei (China). Dept. of Radiation Oncology; Cheng, W.H.; Chang, C.I. [Taipei Medical Univ., Wan Fang Hospital, Taipei (China). Dept. of Hemato-Ongology; Lin, W.C. [Taipei Medical Univ., Wan Fang Hospital, Taipei (China). Div. of Thoracic Surgery; Wu, L.L. [National Taiwan Univ. Hospital, Taipei (China). Dept. of Ophthalmology; Lee, H.L. [Taipei Medical Univ., Wan Fang Hospital, Taipei (China). Dept. of Radiation-Oncology; Chen, R.J. [National Taiwan Univ. Hospital and National Taiwan Univ., Taipei (China). Dept. of Obstetrics and Gynecology

    2013-08-15

    Background and purpose: Betel nut chewing is associated with oral cavity cancer in Taiwan. OC3 is an oral carcinoma cell line that was established from cells collected from a long-term betel nut chewer who does not smoke. After we found that microRNA-17-5p (miR-17-5p) is induced in OC3 cells, we used this cell line to examine the biological role(s) of this microRNA in response to exposure to ionizing radiation. Materials and methods: A combined SYBR green-based real-time PCR and oligonucleotide ligation assay was used to examine the expression of the miR-17 polycistron in irradiated OC3 cells. The roles of miR-17-5p and p21 were evaluated with specific antisense oligonucleotides (ODN) that were designed and used to inhibit their expression. Expression of the p21 protein was evaluated by Western blotting. The clonogenic assay and annexin V staining were used to evaluate cell survival and apoptosis, respectively. Cells in which miR-17-5p was stably knocked down were used to create ectopic xenografts to evaluate in vivo the role of miR-17-5p. Results: A radiation dose of 5 Gy significantly increased miR-17-5p expression in irradiated OC3 cells. Inhibition of miR-17-5p expression enhanced the radiosensitivity of the OC3 cells. We found that miR-17-5p downregulates radiation-induced p21 expression in OC3 cells and, by using a tumor xenograft model, it was found that p21 plays a critical role in increasing the radiosensitivity of OC3 cells in vitro and in vivo. Conclusion: miR-17-5p is induced in irradiated OC3 cells and it downregulates p21 protein expression, contributing to the radioresistance of OC3 cells. (orig.)

  20. MicroRNA-17-5p post-transcriptionally regulates p21 expression in irradiated betel quid chewing-related oral squamous cell carcinoma cells

    Background and purpose: Betel nut chewing is associated with oral cavity cancer in Taiwan. OC3 is an oral carcinoma cell line that was established from cells collected from a long-term betel nut chewer who does not smoke. After we found that microRNA-17-5p (miR-17-5p) is induced in OC3 cells, we used this cell line to examine the biological role(s) of this microRNA in response to exposure to ionizing radiation. Materials and methods: A combined SYBR green-based real-time PCR and oligonucleotide ligation assay was used to examine the expression of the miR-17 polycistron in irradiated OC3 cells. The roles of miR-17-5p and p21 were evaluated with specific antisense oligonucleotides (ODN) that were designed and used to inhibit their expression. Expression of the p21 protein was evaluated by Western blotting. The clonogenic assay and annexin V staining were used to evaluate cell survival and apoptosis, respectively. Cells in which miR-17-5p was stably knocked down were used to create ectopic xenografts to evaluate in vivo the role of miR-17-5p. Results: A radiation dose of 5 Gy significantly increased miR-17-5p expression in irradiated OC3 cells. Inhibition of miR-17-5p expression enhanced the radiosensitivity of the OC3 cells. We found that miR-17-5p downregulates radiation-induced p21 expression in OC3 cells and, by using a tumor xenograft model, it was found that p21 plays a critical role in increasing the radiosensitivity of OC3 cells in vitro and in vivo. Conclusion: miR-17-5p is induced in irradiated OC3 cells and it downregulates p21 protein expression, contributing to the radioresistance of OC3 cells. (orig.)

  1. Increased Expression of mir-34a-5p and Clinical Association in Acute Ischemic Stroke Patients and in a Rat Model

    Liang, Ting-ying; Lou, Ji-yu

    2016-01-01

    Background MiRNA is widely recognized as the most important regulator in various diseases. However, there has been little research regarding miRNA expression and its involvement in ischemic stroke. Material/Methods In this study, we investigated the pattern of miRNA-34a-5p expression along with its clinical application in human ischemic stroke and in an in vivo rat model. We recruited 102 cerebral ischemia patients and 97 health controls for this study. Clinical data were gathered and recorded with the help of questionnaires. Blood samples were obtained from patients within 72 h after cerebral ischemia. National Institutes of Health Stroke Scale (NIHSS), Acute Stroke Treatment (TOAST), and infarct volume were used to analyze the correlation of miRNA-34a-5p expression and clinical information. In addition, blood samples and brain tissues were collected from an established middle cerebral artery occlusion (MCAO) model consisting of 20 adult male mice at 24 h after the MCAO. Expression level of miRNA-34a-5p was detected by real-time polymerase chain reactions. Results Results showed overexpression of miRNA-34a-5p in acute ischemic stroke patients blood samples compared to the controls (p<0.05). Also, large and small arterial strokes types demonstrated elevated miRNA-34a-5p expression levels. Further correlation analysis revealed a negative association between miRNA-34a-5p and NIHSS scores (r=−0.692 p<0.05) and infarct volume (r=−0.719, p<0.05). Moreover, in vivo experiment results showed significant up-regulated expression of miRNA-34a-5p in middle cerebral artery occlusion compared to controls, along with a positive correlation between miRNA-34a-5p in blood and brain (r=0.742, p<0.05). Conclusions Our results suggest there is a potential regulatory role of miRNA-34a-5p in acute ischemic stroke, which could serve as a therapeutic target or biomarker in stroke prognosis. PMID:27545688

  2. Androgen receptor regulated microRNA miR-182-5p promotes prostate cancer progression by targeting the ARRDC3/ITGB4 pathway.

    Yao, Jingjing; Xu, Chen; Fang, Ziyu; Li, Yaoming; Liu, Houqi; Wang, Yue; Xu, Chuanliang; Sun, Yinghao

    2016-05-20

    MicroRNAs (miRNAs) are important endogenous gene regulators that play key roles in prostate cancer development and metastasis. However, specific miRNA expression patterns in prostate cancer tissues from Chinese patients remain largely unknown. In this study, we compared miRNA expression patterns in 65 pairs of prostate cancer and para-cancer tissues by RNA sequencing and found that miR-182-5p was the most up-regulated miRNA in prostate cancer tissues. The result was validated using realtime PCR in 18 pairs of prostate cancer and para-cancer tissues. In in vitro analysis, it was confirmed that miR-182-5p promotes prostate cancer cell proliferation, invasion and migration and inhibit apoptosis. In addition, the androgen receptor directly regulated the transcription of miR-182-5p, which could target to the 3'UTR of ARRDC3 mRNA and affect the expression of ARRDC3 and its downstream gene ITGB4. For the in vivo experiment, miR-182-5p overexpression also promoted the growth and progression of prostate cancer tumors. In this regard, we suggest that miR-182-5p may be a key androgen receptor-regulated factor that contributes to the development and metastasis of Chinese prostate cancers and may be a potential target for the early diagnosis and therapeutic studies of prostate cancer. PMID:27109471

  3. MicroRNA-21a-5p Functions on the Regulation of Melanogenesis by Targeting Sox5 in Mouse Skin Melanocytes.

    Wang, Pengchao; Zhao, Yuanyuan; Fan, Ruiwen; Chen, Tianzhi; Dong, Changsheng

    2016-01-01

    MicroRNAs (miRNAs) play an important role in regulating almost all biological processes. miRNAs bind to the 3' untranslated region (UTR) of mRNAs by sequence matching. In a previous study, we demonstrated that miR-21 was differently expressed in alpaca skin with different hair color. However, the molecular and cellular mechanisms for miR-21 to regulate the coat color are not yet completely understood. In this study, we transfected miR-21a-5p into mouse melanocytes and demonstrated its function on melanogenesis of miR-21a-5p by targeting Sox5, which inhibits melanogenesis in mouse melanocytes. The results suggested that miR-21a-5p targeted Sox5 gene based on the binding site in 3' UTR of Sox5 and overexpression of miR-21a-5p significantly down-regulated Sox5 mRNA and protein expression. Meanwhile, mRNA and protein expression of microphthalmia transcription factor (MITF) and Tyrosinase (TYR) were up-regulated, which subsequently make the melanin production in melanocytes increased. The results suggest that miR-21a-5p regulates melanogenesis via MITF by targeting Sox5. PMID:27347933

  4. MicroRNA-21a-5p Functions on the Regulation of Melanogenesis by Targeting Sox5 in Mouse Skin Melanocytes

    Pengchao Wang

    2016-06-01

    Full Text Available MicroRNAs (miRNAs play an important role in regulating almost all biological processes. miRNAs bind to the 3′ untranslated region (UTR of mRNAs by sequence matching. In a previous study, we demonstrated that miR-21 was differently expressed in alpaca skin with different hair color. However, the molecular and cellular mechanisms for miR-21 to regulate the coat color are not yet completely understood. In this study, we transfected miR-21a-5p into mouse melanocytes and demonstrated its function on melanogenesis of miR-21a-5p by targeting Sox5, which inhibits melanogenesis in mouse melanocytes. The results suggested that miR-21a-5p targeted Sox5 gene based on the binding site in 3′ UTR of Sox5 and overexpression of miR-21a-5p significantly down-regulated Sox5 mRNA and protein expression. Meanwhile, mRNA and protein expression of microphthalmia transcription factor (MITF and Tyrosinase (TYR were up-regulated, which subsequently make the melanin production in melanocytes increased. The results suggest that miR-21a-5p regulates melanogenesis via MITF by targeting Sox5.

  5. Information Management and Governance in UK Higher Education Institutions: Bringing IT in from the Cold

    Coen, Michael; Kelly, Ursula

    2007-01-01

    In the 21st Century, IT Governance is, within the broader corporate governance context, critical for all organisations. Those without an IT governance strategy face significant risks; those with one perform measurably better (Calder 2005). There has been little field based research on IT governance, and few publications help managers understand…

  6. Cloud Computing Governance Lifecycle

    Soňa Karkošková

    2016-06-01

    Full Text Available Externally provisioned cloud services enable flexible and on-demand sourcing of IT resources. Cloud computing introduces new challenges such as need of business process redefinition, establishment of specialized governance and management, organizational structures and relationships with external providers and managing new types of risk arising from dependency on external providers. There is a general consensus that cloud computing in addition to challenges brings many benefits but it is unclear how to achieve them. Cloud computing governance helps to create business value through obtain benefits from use of cloud computing services while optimizing investment and risk. Challenge, which organizations are facing in relation to governing of cloud services, is how to design and implement cloud computing governance to gain expected benefits. This paper aims to provide guidance on implementation activities of proposed Cloud computing governance lifecycle from cloud consumer perspective. Proposed model is based on SOA Governance Framework and consists of lifecycle for implementation and continuous improvement of cloud computing governance model.

  7. Risk Management in IT Governance Framework

    Mirela GHEORGHE

    2011-12-01

    Full Text Available The concept of governance has an already old contour: the system by which business corporations are directed and controlled. The most praised principles regarding shareholder rights, transparency and board accountability now constitute the foundation for new tendencies evolved from such ground. Executive compensation, transparency and shareholder reporting are new issues attached to board responsibilities. Besides such almost negative approaches the board faces a more and more prominent role from risk management and IT governance perspective. Nowadays is generally acknowledged that the board is in charge for managing and controlling the risks to assets of the enterprises and business future. IT Governance has emerged as a support for corporate governance, as an important part of board’s striving efforts to perform better in a competition environment. These responsibilities, risk management and IT Governance, remain within the framework of old concept of corporate governance and are fed from its substance. The interaction between these concepts is the core interest of this research.IT Governance is defined as procedures and policies established in order to assure that the IT system of an organization sustains its goals and strategies. The management of the organisations face a new challenge: structural redefinition of the IT component in order to create plus value and to minimize IT risks through an efficient management of all IT resources of the organisation. The evolution of the present IT environment is a natural process according to which business environment should adapt.

  8. The Knowledge Governance Approach

    Foss, Nicolai

    2005-01-01

    apparatus influences knowledge processes, such as sharing, retaining and creating knowledge. It insists on clear behavioural foundations, adopts an economizing perspective and examines efficient alignment between knowledge transactions with diverse characteristics and governance structures and mechanisms...... with diverse capabilities of handling these transactions. Various open research issues that a knowledge governance approach may illuminate are sketched. Although knowledge governance draws clear inspiration from organizational economics and `rational' organization theory, it recognizes that knowledge...... represents various challenges to more `closed' social science disciplines, notably economics....

  9. Codes of Good Governance

    Beck Jørgensen, Torben; Sørensen, Ditte-Lene

    2013-01-01

    Good governance is a broad concept used by many international organizations to spell out how states or countries should be governed. Definitions vary, but there is a clear core of common public values, such as transparency, accountability, effectiveness, and the rule of law. It is quite likely......, however, that national views of good governance reflect different political cultures and institutional heritages. Fourteen national codes of conduct are analyzed. The findings suggest that public values converge and that they match model codes from the United Nations and the European Council as well as...

  10. e-Government

    Vellendorfová, Jana

    2010-01-01

    Although the e-Government was mentioned more frequently, especially because of data boxes, its origin dates back to 90th the 20th century. Then the first efforts to development of information systems began to connect various governmental offices. However, these efforts haven't been very successful. Subsequently, different e-Government services start developing and this is what the diploma thesis is about. First it outlines the progress of the e-Government. Then this thesis attempts to the e-G...

  11. Governance Issues for SMEs

    Thomas Clarke

    2014-09-01

    Full Text Available This paper draws on research into the corporate governance practices of small and medium enterprises (SMEs listed on the Australian Securities Exchange. Interviews were conducted with the directors and/or company secretaries of 19 SMEs. The aim of the research was to explore not only SME corporate governance structures and processes but how SMEs had chosen to implement the Principles and the reasons for their choices. The paper addresses the issue of whether the ASX Corporate Governance Principles and Recommendations were appropriate for SMEs. It describes the SME responses to the requirements, how these differ from those of larger companies, and how these differences impact on small companies.

  12. 政府财政介入幼儿教育的必要性、问题及其策略分析%Analysis of the Necessity, Problems and Strategy of Government Financial Intervention in Early Childhood Education

    于涛

    2012-01-01

    Governments at all levels have the responsibility to develop early childhood education in China.However, the problems in gov- ernments' financial intervention seriously hinder the development of early childhood education. Due to the weak financial investment in early childhood education, poor coordination of financial deparmaents, and the lack of legal guarantee and the inadequate financial invesmaent that does not catch up with the speed of social development, the paper puts forward some proposals for developing early childhood education in terms of the responsibilities of relevant depamnents of governments at all levels, the establishment of legal guarantee and the setup of the special edu- cation fimds for early childhood education in order to provide govemn~ents with some references for exploring the development of early childhood education.%大力发展幼儿教育是我国各级政府义不容辞的责任,但是在政府作为中存在着许多的问题严重阻碍了幼儿教育的发展。针对我国当前幼儿教育财政投入薄弱、政府财政介入部门协调力度疲软、缺乏法律保障以及财政投入落后于社会发展速度等问题,从各级政府及相关部门职责、制定法律保障和设立幼儿教育专项基金等方面给出发展幼儿教育事业的一些建议,以期为政府探索发展幼儿教育事业提供一些参考。

  13. Oscillator Strengths and Predissociation Rates for W-X Bands and the 4P5P Complex in 13C18O

    Eidelsberg, Michele; Lemaire, Jean Louis; Federman, Steven; Stark, Glenn; Heays, Alan; Gavilan, Lisseth; Lyons, James R.; Smith, Peter L.; de Oliveira, Nelson; Joyeux, Denis

    2015-06-01

    In our ongoing experiments on the DESIRS beam-line at the SOLEIL Synchrotron, we are acquiring the necessary data on oscillator strengths and predissociation rates for modeling CO photochemistry in astronomical environments. A VUV Fourier Transform Spectrometer with a resolving power of about 350,000 allows us to discern individual lines in electronic transitions. Here we focus on results obtained from absorption spectra of 13C18O, for the W ^1Π - X ^1σ^+ bands with v'=0, 2, {and} 3 and v''=0 and three resolved bands involving transitions to the upper levels 4pπ(2), 5pπ(0), and 5pσ(0) of the 4p(2) and 5p(0) complexes. We compare our results with earlier determinations for this isotopologue of CO, as well as with our SOLEIL measurements on 12C16O, 13C16O, and 12C18O.

  14. A Screen Identifies the Oncogenic Micro-RNA miR-378a-5p as a Negative Regulator of Oncogene-Induced Senescence

    Kooistra, Susanne Marije; Rudkjær, Lise Christine; Lees, Michael James; Steinhauer, Cornelia; Johansen, Jens Vilstrup; Helin, Kristian

    2014-01-01

    Oncogene-induced senescence (OIS) can occur in response to hyperactive oncogenic signals and is believed to be a fail-safe mechanism protecting against tumorigenesis. To identify new factors involved in OIS, we performed a screen for microRNAs that can overcome or inhibit OIS in human diploid......-associated β-galactosidase. Moreover, cells with ectopic expression of miR-378a-5p retain proliferative capacity even in the presence of an activated Braf oncogene. Finally, we identified several miR-378a-5p targets in diploid fibroblasts that might explain the mechanism by which the microRNA can delay OIS. We...... speculate that miR-378a-5p might positively influence tumor formation by delaying OIS, which is consistent with a known pro-oncogenic function of this microRNA....

  15. MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes

    Yan, Li; Cao, Rui; Liu, YuanBo; Wang, LianZhao; Pan, Bo; Lv, XiaoYan; Jiao, Hu; Zhuang, Qiang; Sun, XueJian; Xiao, Ran

    2016-01-01

    Keloid is the abnormal wound healing puzzled by the aggressive growth and high recurrence rate due to its unrevealed key pathogenic mechanism. MicroRNAs contribute to a series of biological processes including epithelial-mesenchymal transition (EMT) and cells stemness involved in fibrotic disease. Here, using microRNAs microarray analysis we found mir-21-5p was significantly up-regulated in keloid epidermis. To investigate the role of miR-21-5p in keloid pathogenesis, we transfected miR-21-5p mimic or inhibitor in keloid keratinocytes and examined the abilities of cell proliferation, apoptosis, migration and invasion, the expressions of EMT-related markers vimentin and E-cadherin and stem-like cells-associated markers CD44 and ALDH1, and the involvement of PTEN and the signaling of AKT and ERK. Our results demonstrated that up-regulation or knockdown of miR-21-5p significantly increased or decreased the migration, invasion and sphere-forming abilities of keloid keratinocytes, and the phenotype of EMT and cells stemness were enhanced or reduced as well. Furthermore, PTEN and p-AKT were shown to participate in the regulation of miR-21-5p on EMT phenotypes and stemness signatures of keloid keratinocytes, which might account for the invasion and recurrence of keloids. This molecular mechanism of miR-21-5p on keloid keratinocytes linked EMT with cells stemness and implicated novel therapeutic targets for keloids. PMID:27596120

  16. miR-150-5p and miR-133a suppress glioma cell proliferation and migration through targeting membrane-type-1 matrix metalloproteinase.

    Sakr, Moustafa; Takino, Takahisa; Sabit, Hemragul; Nakada, Mitsutoshi; Li, Zichen; Sato, Hiroshi

    2016-08-10

    Gliomas are the most frequent primary tumors of the brain, and there is no successful treatment for highly malignant gliomas. MicroRNAs (miRNAs) are involved in a variety of biological processes. Recent studies showed that miR-150-5p and miR-133a are downregulated in various human malignancies, and one of target mRNAs was shown to be membrane-type 1 matrix metalloproteinase (MT1-MMP) mRNA. However, their detailed role in the processes of cancer remains to be determined. Here we found that miR-150-5p and miR-133a expression was significantly downregulated in glioma tissues compared with normal tissues, and that MT1-MMP expression was inversely upregulated in glioma tissues. Knockdown of MT1-MMP by specific siRNAs in U87 and U251 glioma cells induced suppression of cell proliferation and invasion/migration. Transfection of miR-150-5p or miR-133a mimics into glioma cell lines reduced MT1-MMP expression and MMP-2 activation by these cells, and cell proliferation and invasion/migration were also suppressed by it. Co-transfection of specific inhibitor oligo DNA for miR-150-5p or miR-133a abrogated miR-150-5p or miR-133a mimic's actions, respectively. These results suggest that miR-150-5p and miR-133a may suppress malignancy of gliomas by targeting MT1-MMP, and could be used as an anti-metastatic therapy for glioma patients. PMID:27154818

  17. MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes.

    Yan, Li; Cao, Rui; Liu, YuanBo; Wang, LianZhao; Pan, Bo; Lv, XiaoYan; Jiao, Hu; Zhuang, Qiang; Sun, XueJian; Xiao, Ran

    2016-01-01

    Keloid is the abnormal wound healing puzzled by the aggressive growth and high recurrence rate due to its unrevealed key pathogenic mechanism. MicroRNAs contribute to a series of biological processes including epithelial-mesenchymal transition (EMT) and cells stemness involved in fibrotic disease. Here, using microRNAs microarray analysis we found mir-21-5p was significantly up-regulated in keloid epidermis. To investigate the role of miR-21-5p in keloid pathogenesis, we transfected miR-21-5p mimic or inhibitor in keloid keratinocytes and examined the abilities of cell proliferation, apoptosis, migration and invasion, the expressions of EMT-related markers vimentin and E-cadherin and stem-like cells-associated markers CD44 and ALDH1, and the involvement of PTEN and the signaling of AKT and ERK. Our results demonstrated that up-regulation or knockdown of miR-21-5p significantly increased or decreased the migration, invasion and sphere-forming abilities of keloid keratinocytes, and the phenotype of EMT and cells stemness were enhanced or reduced as well. Furthermore, PTEN and p-AKT were shown to participate in the regulation of miR-21-5p on EMT phenotypes and stemness signatures of keloid keratinocytes, which might account for the invasion and recurrence of keloids. This molecular mechanism of miR-21-5p on keloid keratinocytes linked EMT with cells stemness and implicated novel therapeutic targets for keloids. PMID:27596120

  18. Government Risk-Bearing

    1993-01-01

    The u.s. government bulks large in the nation's financial markets. The huge volume of government-issued and -sponsored debt affects the pricing and volume ofprivate debt and, consequently, resource allocation between competing alternatives. What is often not fully appreciated is the substantial influence the federal government wields overresource allocation through its provisionofcreditandrisk-bearing services to the private economy. Because peopleand firms generally seekto avoid risk, atsomeprice they are willing to pay another party to assume the risk they would otherwise face. Insurance companies are a class of private-sector firms one commonly thinks of as providing these services. As the federal government has expanded its presence in the U.S. economy during this century, it has increasingly developed programs aimed at bearing risks that the private sector either would not take on at any price, or would take on but atapricethoughtto besogreatthatmostpotentialbeneficiarieswouldnotpurchase the coverage. To...

  19. Managing e-government

    Rose, Jeremy; Persson, John Stouby; Heeager, Lise Tordrup;

    2015-01-01

    Public sector managers take much of the responsibility for selecting, commissioning, implementing and realising benefits from information technology (IT) projects. However, e-Government initiatives often suffer from complexity, vision failure, lack of goal clarity and insufficient commitment...

  20. Temperature-Dependent Electron Transport in In0.5Ga0.5P/GaAs Grown by MOVPE

    S. Acar; A. Yíldíz; M. Kasap; M. Bosi

    2007-01-01

    @@ Hall effect measurements in undoped In0.5Ga0.5P/GaAs alloy grown by metal organic vapour-phase epitaxy (MOVPE) have been carried out in the temperature range 15-350K. The experimental results are analysed using a two-band model including conduction band transport calculated using an iterative solution of the Boltzmann equation. A good agreement was obtained between theory and experiment. The impurity contents of In0.5Ga0.5P/GaAs alloy, such as donor density ND, acceptor density NA and donor activation energy εD, were also determined.

  1. Explaining governance outcomes

    Fawcett, Paul; Daugbjerg, Carsten

    2012-01-01

    network analysis school, which has focused on the relationship between processes of interest intermediation and their impact on policy-making outcomes.We examine how each school is underpinned by important epistemological differences between positivist, interpretivist and critical realist approaches...... as overarching measures of how governance outcomes vary between different governance arrangements. This provides the basis for a broader discussion of how these outcomes are conditioned by both a network’s structural characteristics and the way in which it is managed....

  2. Managerial Corporate Governance Communication

    Silvio M. Brondoni

    2006-01-01

    Corporate governance communication has steadily become more important as markets have globalised. On open markets, the specific report on economic-financial disclosures supplements the communication system of companies, whose policies are founded strongly on integration, in order to tackle an economic context that is characterised by strong competitive dynamics and growing managerial complexity. Globalisation tends to underline the importance of corporate governance communication designed to ...

  3. Governing Logistics Information Platforms

    Klievink, A.J.; Aldewereld, H.M.; Knol, A.; Tan, Y. H.

    2014-01-01

    The Extended Single Window (ESW) project aims to support goods flows by Information and Communication Technology (ICT). Specifically, the project takes the concept of Single Windows (often used in the sense that governments offer a single portal or interface to which businesses can submit information, supporting re-ruse by multiple agencies and coordination of government activities) and includes the business side; creating an Extended Single Window. An Extended Single Window includes business...

  4. Districting and Government Overspending

    Reza Baqir

    2001-01-01

    The common-pool problem is a central issue in the relationship between the political structure of jurisdictions and the size of public spending. Models predict that, other things being equal, greater political districting of a jurisdiction raises the scale of government. This paper presents new evidence on this and related predictions from a cross-section of city governments in the United States. The main finding is that one additional legislator is associated, on average, with 3 percent larg...

  5. Corporate Governance in China

    He, Yan

    2011-01-01

    China has become the world's second largest economic entity following its economic reform process begun over 30 years ago. Corporate governance plays an important role in China economic success, but it also has many problems. These include the concentration of state ownership, management accountability and shareholder rights. Economic reform has made the problems more apparent. This thesis studies the evolution of corporate governance with the China's economic reform process, and explores i...

  6. Minsky on "Big Government"

    Daniel de Santana Vasconcelos

    2014-03-01

    Full Text Available This paper objective is to assess, in light of the main works of Minsky, his view and analysis of what he called the "Big Government" as that huge institution which, in parallels with the "Big Bank" was capable of ensuring stability in the capitalist system and regulate its inherently unstable financial system in mid-20th century. In this work, we analyze how Minsky proposes an active role for the government in a complex economic system flawed by financial instability.

  7. Governing by planning inquiry

    This pamphlet presents a critique of planning inquiries as a method of formulating central government policies, using the Windscale and Sizewell ''B'' inquiries as particular examples. The author argues that government, not Inquiry Inspectors, should shoulder responsibility for policy recommendations on such serious issues. Further, he suggests that advocates and instigators of such schemes as those described may be obliged to offer evidence in support of their case and cross-examine opponents in areas completely outside their own sphere of knowledge. (UK)

  8. IT governance for SMEs

    Devos, Jan

    2010-01-01

    IT Governance is placing information technology (IT) and information systems (IS) on the agenda of CEOs. However research on the IT/IS value proposition is elaborate and strongly focused on large firms. Despite the numerous successes illustrating the advantages of IT Governance in organizations it is commonly accepted that the processes of developing and using IS are not straightforward. The focus of this research is the complex relation of IT/IS and small and medium-sized enterprises (SMEs) ...

  9. Corporate Governance. Case Studies

    Manuel, Eduardo

    2007-01-01

    This paper pretends to do a theoretical approach of Corporate Governance, having as support some case studies about companies like Coca-Cola, Nokia, Microsoft, and Amazon.com. The methodology adopted for this work is based in information from these companies available in their websites and annual reports. I concluded that both companies show the corporate governance components according to their core business and their environmental business.

  10. eGovernment

    Machačová, Eva

    2012-01-01

    Summary This thesis is concerned with the use of e-Government in civil services especially at the work of The Czech Telecommunication Office. First of all there are described the basics of e-Government, its history and the most important terms, that are connected with the electronic services. Above all it is focused on delivering documents. Nowadays there are coexisting two ways of delivering. The first possibility is delivering by electronic mailbox; the second one is the traditio...

  11. Municipal Climate Governance and Formation of Local Transition places

    Søndergård, Bent; Stauning, Inger; Holm, Jesper

    environment etc.) and of specific local actor constellations of transition (NGO´s, entrepreneurs, companies), which imply that there can be big potentials in defining and implementing local transition strategies • Local projects and experiments concerning the low carbon economy and climate mitigation...... are experimenting with new governance concepts directed towards the integration of citizens, enterprises and sector actors in long term transition processes. The paper discusses and characterizes innovative municipality practices and concepts of governance by analyzing governance concepts of...

  12. The emerging knowledge governance approach : challenges and characteristics

    Foss, Nicolai Juul

    2006-01-01

    The “knowledge governance approach” is characterized as a distinctive, emerging approach that cuts across the fields of knowledge management, organisation studies, strategy, and human resource management. Knowledge governance is taken up with how the deployment of governance mechanisms influences knowledge processes, such as sharing, retaining and creating knowledge. It insists on clear micro (behavioural) foundations, adopts an economizing perspective, and examines the links between knowledg...

  13. The Governance of Knowledge: Perspectives from Brunei Darussalam and Malaysia

    Purwaningrum, Farah; Evers, Hans-Dieter; Ariff Lim, Syamimi; Anthony Banyouko, Ndah

    2014-01-01

    The paper revisits the concept of knowledge governance by drawing on the experience of building knowledge clusters in two countries; Malaysia and Brunei Darussalam. It explores the strategies by which a country may take up the governance of knowledge, in the context of avoiding the knowledge trap drawing on experiences of Southeast Asian countries. We posit that an investigation of knowledge governance would require a study of the formal and informal institutional arrangements allowing knowle...

  14. The Role of Governance in Corporate Social Responsibility

    de Graaf, J.; Stoelhorst, W., J

    2013-01-01

    This article extends the corporate social performance (CSP) model by studying the role of governance structures and governance systems in shaping corporate social responsibility. The authors argue that a governance perspective offers a fruitful research strategy both to study empirically how firms balance the competing moral frameworks and political philosophies that are part and parcel of defining their role in society and to further the theoretical integration of the descriptive and normati...

  15. Open Government and (Linked (Open (Government (Data

    Christian Philipp Geiger

    2012-12-01

    Full Text Available This article explores the opening and the free usage of stored public sector data, supplied by state. In the age of Open Government and Open Data it’s not enough just to put data online. It should be rather weighed out whether, how and which supplied public sector data can be published. Open Data are defined as stored data which could be made accessible in a public interest without any restrictions for usage and distribution. These Open Data can possibly be statistics, geo data, maps, plans, environmental data and weather data in addition to materials of the parliaments, ministries and authorities. The preparation and the free access to existing data permit varied approaches to the reuse of data, discussed in the article. In addition, impulses can be given for Open Government – the opening of state and administration, to more transparency, participation and collaboration as well as to innovation and business development. The Open Data movement tries to get to the bottom of current publication processes in the public sector which could be formed even more friendly to citizens and enterprises.

  16. Shared Governance and Regional Accreditation: Institutional Processes and Perceptions

    McGrane, Wendy L.

    2013-01-01

    This qualitative single-case research study was conducted to gain deeper understanding of the institutional processes to address shared governance accreditation criteria and to determine whether institutional processes altered stakeholder perceptions of shared governance. The data collection strategies were archival records and personal…

  17. The Reform of the World Bank Governance Structure and China’ s strategies%世界银行治理结构改革与中国的应对策略∗

    叶扬; 张文

    2015-01-01

    The World Bank plays an important role in global economic governance. With the rise of emerging economies and frequent occurrence of financial crisis, institutional defects of the World Bank ’ s governance structure become more and more apparent. Therefore, corresponding reform is imperative. The biggest obstacle to reform is that the World Bank is not only public organization but also a corporation. The dual attributes lead to the disagreement on the reform direction. However, the conflict between the developed countries and the developing countries is not irreconcilable. They can cooperate on many issues, such as alleviating poverty. China should positively promote the reform of the World Bank governance structure. Firstly, China must clear the position of“responsible and capable power” and show a positive attitude to promote the reform. Secondly, closely focus on the theme of development and concern long⁃term interests. Thirdly, step up participation of personnel arrangements in the World Bank. Finally, actively build a formal coordination mechanism under which developing countries can communicate and cooperate with each other.%世界银行在全球经济治理中发挥着重要作用,但随着新兴经济体的崛起和近年来金融危机、债务危机频发,世界银行治理结构所存在的制度性缺陷显露无遗,相应改革势在必行。但是,由于世界银行具有公共组织与股份公司的双重属性,使得改革方向出现分歧,改革进程推进缓慢。从根本上说,世界银行改革中发达国家与发展中国家并不存在不可调和的利益冲突,在减贫等问题上双方存在着合作的基础。中国应积极推进世界银行治理结构改革:首先,必须明确“负责任、有作为的大国”定位,表现出推动改革的积极态度;其次,要紧密围绕“发展”主题,注重长远利益;再次,要加强对世界银行人事安排的参与;最后,要积极构

  18. 世界银行治理结构改革与中国的应对策略∗%The Reform of the World Bank Governance Structure and China’ s strategies

    叶扬; 张文

    2015-01-01

    世界银行在全球经济治理中发挥着重要作用,但随着新兴经济体的崛起和近年来金融危机、债务危机频发,世界银行治理结构所存在的制度性缺陷显露无遗,相应改革势在必行。但是,由于世界银行具有公共组织与股份公司的双重属性,使得改革方向出现分歧,改革进程推进缓慢。从根本上说,世界银行改革中发达国家与发展中国家并不存在不可调和的利益冲突,在减贫等问题上双方存在着合作的基础。中国应积极推进世界银行治理结构改革:首先,必须明确“负责任、有作为的大国”定位,表现出推动改革的积极态度;其次,要紧密围绕“发展”主题,注重长远利益;再次,要加强对世界银行人事安排的参与;最后,要积极构建世界银行框架下发展中国家沟通与合作的正式协调机制。%The World Bank plays an important role in global economic governance. With the rise of emerging economies and frequent occurrence of financial crisis, institutional defects of the World Bank ’ s governance structure become more and more apparent. Therefore, corresponding reform is imperative. The biggest obstacle to reform is that the World Bank is not only public organization but also a corporation. The dual attributes lead to the disagreement on the reform direction. However, the conflict between the developed countries and the developing countries is not irreconcilable. They can cooperate on many issues, such as alleviating poverty. China should positively promote the reform of the World Bank governance structure. Firstly, China must clear the position of“responsible and capable power” and show a positive attitude to promote the reform. Secondly, closely focus on the theme of development and concern long⁃term interests. Thirdly, step up participation of personnel arrangements in the World Bank. Finally, actively build a formal coordination mechanism

  19. Greenhouse gas strategy

    Because the overall effects of climate change will likely be more pronounced in the North than in other parts of the country, the Government of the Northwest Territories considers it imperative to support global and local actions to reduce greenhouse gas emissions. Government support is manifested through a coordinating role played by senior government representatives in the development of the NWT Greenhouse Gas Strategy, and by participation on a multi-party working committee to identify and coordinate northern actions and to contribute a northern perspective to Canada's National Climate Change Implementation Strategy. This document outlines the NWT Government's goals and objectives regarding greenhouse gas emission reduction actions. These will include efforts to enhance awareness and understanding; demonstrate leadership by putting the Government's own house in order; encouraging action across sectors; promote technology development and innovation; invest in knowledge and building the foundation for informed future decisions. The strategy also outlines the challenges peculiar to the NWT, such as the high per person carbon dioxide emissions compared to the national average (30 tonnes per person per year as opposed to the national average of 21 tonnes per person per year) and the increasing economic activity in the Territories, most of which are resource-based and therefore energy-intensive. Appendices which form part of the greenhouse gas strategy document, provide details of the potential climate change impact in the NWT, a detailed explanation of the proposed measures, an emission forecast to 2004 from industrial processes, fuel combustion and incineration, and a statement of the official position of the Government of the NWT on climate change

  20. One Size Does Not Fit All: Best Practices for Data Governance

    OTTO, Boris

    2011-01-01

    Data Governance defines roles and responsibilities for the management and use of corporate data. While the need for Data Governance is undoubted, companies often encounter difficulties in designing Data Governance in their organization. There is no one size fits all solution. As companies are different in terms of their business strategy, their diversification breadth, their industry, IT strategy and application system landscape, Data Governance must take into account this diversity. What wor...