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Sample records for 52-week treatment period

  1. Etoricoxib in the treatment of osteoarthritis over 52-weeks: a double-blind, active-comparator controlled trial [NCT00242489

    Olaleye Joseph

    2005-12-01

    Full Text Available Abstract Background The aim of this study was to evaluate the long-term efficacy and tolerability of etoricoxib, a COX-2 selective inhibitor, in osteoarthritis (OA patients. Methods A double-blind, randomized, multicenter study was conducted in 617 patients with OA of the knee. The base study was 14 weeks in duration and consisted of 2 parts; in Part I (6 weeks, patients were allocated to once daily oral etoricoxib 5, 10, 30, 60, 90 mg or placebo. In Part II (8 weeks; the placebo, etoricoxib 5 and 10 mg groups were reallocated to etoricoxib 30, 60, or 90 mg qd or diclofenac 50 mg t.i.d. Treatment was continued for consecutive 12 and 26 week extensions. Primary efficacy endpoints were the WOMAC VA 3.0 pain subscale and investigator global assessment of disease status. Safety and tolerability were assessed by collecting adverse events throughout the study. Results Compared with placebo, the etoricoxib groups displayed significant (p Conclusion In this extension study, etoricoxib, at doses ranging from 30 to 90 mg, demonstrated a maintenance of significant clinical efficacy in patients with OA through 52 weeks of treatment. Etoricoxib displayed clinical efficacy similar to diclofenac 150 mg and was generally well tolerated.

  2. Long-Term Treatment Outcome in Adult Male Prisoners With Attention-Deficit/Hyperactivity Disorder: Three-Year Naturalistic Follow-Up of a 52-Week Methylphenidate Trial.

    Ginsberg, Ylva; Långström, Niklas; Larsson, Henrik; Lindefors, Nils

    2015-10-01

    Despite high rates of attention-deficit/hyperactivity disorder (ADHD) among adult lawbreakers, particularly the long-term effects of ADHD pharmacotherapy remain unclear, not the least because of ethical challenges with preventing control subjects in randomized controlled trials from receiving medication over prolonged time. We followed up adult male prisoners with ADHD who completed a 5-week randomized, double-blind, placebo-controlled trial followed by a 47-week open-label extension of osmotic-release oral system methylphenidate in a Swedish high-security prison from 2007 to 2010 (ClinicalTrials.gov: NCT00482313). Twenty-five trial completers were prospectively followed up clinically 1 year (24/25, 96% participated fully or in part) and 3 years (20/25, 80% participation) after trial regarding ADHD symptoms (observer and self-reports), psychosocial functioning, substance misuse, and criminal reoffending. Methylphenidate-related improvements in ADHD symptoms and psychosocial functioning obtained during the 52-week trial were maintained at 1- and 3-year follow-ups. Specifically, after 3 years, 75% (15/20) of the respondents had been released from prison, and 67% of these (10/15) had employment, usually full time. In contrast, nonmedicated respondents at the 3-year follow-up (5/20) reported more ADHD symptoms, functional impairment, and substance misuse compared with currently medicated respondents (15/20). Further, 40% of the respondents self-reported reoffending, indicating a substantially lower relapse rate than expected (70%-80%).In summary, although these observations need validation from new and larger samples, positive effects were maintained after 4 years of methylphenidate treatment. Most study completers were employed and had no relapse in substance misuse or criminality. These results suggest that motivational support and continued medication are important for improved outcome in adult criminal offenders with ADHD. PMID:26284932

  3. Efficacy and safety of treatment with human insulin analogues in daily management of insulin naive patients with type 2 diabetes mellitus: results of multicenter 52-week observational study A1chive

    Marina Vladimirovna Shestakova

    2012-12-01

    Full Text Available Modern insulin analogues allow safe improvement of glycemic control (not accompanied with increase in body mass or rate of severe hypoglycemic events and its efficient maintenance during long period of time. In this paper we present results of multicenter 52-week prospective observational study A1chive (Russian cohort, n=9342, designed to assess safety and efficacy of treatment with human insulin analogues (Levemir®, NovoMix® 30 and NovoRapid® (Novo Nordisk in daily management of insulin naive patients with type 2 diabetes mellitus. Prescription of human insulin analogues resulted in clinically and statistically significant improvement of glycemic control irrespective of initial insulin regimen. Therapy by various regimens (Levemir®, NovoMix® 30 or Levemir® + NovoRapid® under conditions of daily clinical practice leads to marked improvement in glycemic control as measured by HbA1c (-2.9% in 12 month with no evidence for negative influence on tolerability and short-term safety of the treatment. Furthermore, decrease in HbA1c levels was associated with pronounced and stable decrease in fasting and postprandial glucose levels (-5.0 mmol/L and -5.7 mmol/L, respectively. By the end of the follow-up all regimen groups reported improvement of QoL by treatment satisfaction criterion.

  4. Hepatotoxicity in a 52-week randomized trial of short-term versus long-term treatment with buprenorphine/naloxone in HIV-negative injection opioid users in China and Thailand*

    Lucas, Gregory M.; Young, Alicia; Donnell, Deborah; Richardson, Paul; Aramrattana, Apinun; Shao, Yiming; Ruan, Yuhua; Liu, Wei; Fu, Liping; Ma, Jun; Celentano, David D.; Metzger, David; Jackson, J. Brooks; Burns, David

    2014-01-01

    Background Buprenorphine/naloxone (BUP/NX), an effective treatment for opioid dependence, has been implicated in hepatic toxicity. However, as persons taking BUP/NX have multiple hepatic risk factors, comparative data are needed to quantify the risk of hepatoxicity with BUP/NX. Methods We compared rates of alanine aminotransferase (ALT) elevation ≥ grade 3 (ALT ≥ 5.1 times the upper limit of normal) and graded bilirubin elevations in HIV-negative opioid injectors randomized to long-term (52 weeks) or short-term (18 days) medication assisted treatment (LT-MAT and ST-MAT, respectively) with BUP/NX in a multisite trial conducted in China and Thailand. ALT and bilirubin were measured at baseline, 12, 26, 40 and 52 weeks, times temporally remote from BUP/NX exposure in the ST-MAT participants. Results Among1036 subjects with at least one laboratory follow-up measurement, 76 (7%) participants experienced ALT elevation ≥ grade 3. In an intent-to-treat analysis, the risk of ALT events was similar in participants randomized to LT-MAT compared with ST-MAT (adjusted hazard ratio 1.25, 95% confidence interval 0.79 to 1.98). This finding was supported by an as-treated analysis, in which actual exposure to BUP/NX was considered. Hepatitis C seroconversion during follow-up was strongly associated with ALT events. Bilirubin elevations ≥ grade 2 occurred in 2% of subjects, with no significant difference between arms. Conclusions Over 52-week follow-up, the risk of hepatotoxicity was similar in opioid injectors receiving brief and prolonged treatment with BUP/NX. These data suggest that most hepatotoxic events observed during treatment with BUP/NX are due to other factors. PMID:24999060

  5. Long-term (52 weeks) safety and tolerability of umeclidinium in Japanese patients with chronic obstructive pulmonary disease.

    Yamagata, Eiji; Soutome, Toru; Hashimoto, Kenichi; Mihara, Kazuko; Tohda, Yuji

    2016-05-01

    Objective Umeclidinium bromide (UMEC) 62.5 μg is a long-acting muscarinic antagonist (LAMA) that is administered once daily via inhalation for chronic obstructive pulmonary disease (COPD) treatment. The objective of this study was to evaluate the safety and tolerability of long-term treatment with UMEC 125 μg in Japanese patients with COPD. Methods This was a 52 week, multicenter, open-label study to evaluate the safety and tolerability of UMEC 125 μg once daily delivered via a novel dry powder inhaler (nDPI) in Japanese patients with COPD. The primary endpoint was the incidence and severity of all adverse events (AEs) throughout the 52 week treatment period. Clinical trial registration number ClinicalTrials.gov identifier is NCT01702363. Results A total of 153 patients were enrolled in the study. Of these, 131 patients started treatment with UMEC 125 μg, and 111 patients (85%) completed the study. AEs did not differ greatly in incidence over the various time periods (Weeks 0 to 12, 13 to 24, 25 to 36, and 37 to 52 of treatment) and did not increase with continued treatment. The incidence of drug-related AEs associated with the pharmacological effects of LAMAs (including constipation, blurred vision, and thirst) was low. Serious adverse events (SAEs) during the treatment period were reported in 17 patients (13%). SAEs reported in more than one patient were COPD exacerbation and pneumonia (3 patients each, 2%). One SAE of angina pectoris was considered to be drug related. No fatalities were reported during this study. Conclusions No new AEs were identified beyond those attributable to the pharmacological effects of LAMAs. UMEC 125 μg was well tolerated over 52 weeks of treatment in Japanese patients with COPD. PMID:26782971

  6. Treatment for periodic paralysis

    Sansone, [No Value; Meola, G.; Links, T. P.; Panzeri, M.; Rose, M. R.

    2008-01-01

    Background Primary periodic paralyses are rare inherited muscle diseases characterised by episodes of flaccid weakness affecting one or more limbs, lasting several hours to several days, caused by mutations in skeletal muscle channel genes. Objectives The objective of this review was to systematical

  7. The Effects of 52 Weeks of Soccer or Resistance Training on Body Composition and Muscle Function in +65-Year-Old Healthy Males--A Randomized Controlled Trial.

    Thomas Rostgaard Andersen

    Full Text Available The effects of 52 weeks of soccer or resistance training were investigated in untrained elderly men. The subjects aged 68.1±2.1 yrs were randomised into a soccer (SG; n = 9, a resistance (RG; n = 9 and a control group (CG; n = 8. The subjects in SG and RG, respectively, trained 1.7±0.3 and 1.8±0.3 times weekly on average during the intervention period. Muscle function and body composition were determined before and after 16 and 52 weeks of the intervention period. In SG, BMI was reduced by 1.5% and 3.0% (p<0.05 after 16 and 52 weeks, respectively, unchanged in RG and 2% higher (p<0.05 in CG after 52 weeks of the intervention period. In SG, the response to a glucose tolerance test was 16% lower (p<0.05 after 16 wks, but not after 52 wks, compared to before the intervention period, and unchanged in RG and CG. In SG, superoxide dismutase-2 expression was 59% higher (p<0.05 after 52 wks compared to before the intervention period, and unchanged in RG and CG. In RG, upper body lean mass was 3 and 2% higher (p<0.05 after 16 and 52 wks, respectively, compared to before the intervention period, and unchanged in SG and CG. In RG, Akt-2 expression increased by 28% (p<0.01 and follistatin expression decreased by 38% (p<0.05 during the 52-wk intervention period, and was unchanged in SG and CG. Thus, long-term soccer training reduces BMI and improves anti-oxidative capacity, while long-term resistance training impacts muscle protein enzyme expression and increases lean body mass in elderly men. Trial Registration: ClinicalTrials.gov: NCT01530035.

  8. Role of psychological reference points in mergers and acquisitions: 52-week high as a reference price in European takeover activity

    Niinivaara, Timo

    2010-01-01

    This thesis examines the role of a target company’s 52-week high stock price as a psychological reference point in mergers and acquisitions. It builds on a new strand of M&A literature linking mergers and acquisitions to psychological considerations. The first objective of this thesis is to test whether the 52-week high acts a psychological reference point in European mergers and acquisitions. To provide added credibility to my findings and to alleviate any concerns for the results arising fr...

  9. Adding 5-hydroxytryptamine receptor type 3 antagonists may reduce drug-induced nausea in poor insight obsessive-compulsive patients taking off-label doses of selective serotonin reuptake inhibitors: a 52-week follow-up case report

    Martino Matteo

    2010-12-01

    Full Text Available Abstract Poor-insight obsessive-compulsive disorder (PI-OCD is a severe form of OCD where the 'typically obsessive' features of intrusive, 'egodystonic' feelings and thoughts are absent. PI-OCD is difficult to treat, often requiring very high doses of serotonergic drugs as well as antipsychotic augmentation. When this occurs, unpleasant side effects as nausea are common, eventually further reducing compliance to medication and increasing the need for pharmacological alternatives. We present the case of a PI-OCD patient who developed severe nausea after response to off-label doses of the selective serotonin reuptake inhibitor (SSRI, fluoxetine. Drug choices are discussed, providing pharmacodynamic rationales and hypotheses along with reports of rating scale scores, administered within a follow-up period of 52 weeks. A slight reduction of fluoxetine dose, augmentation with mirtazapine and a switch from amisulpride to olanzapine led to resolution of nausea while preserving the anti-OCD therapeutic effect. Mirtazapine and olanzapine have already been suggested for OCD treatment, although a lack of evidence exists about their role in the course of PI-OCD. Both mirtazapine and olanzapine also act as 5-hydroxytryptamine receptor type 3 (5-HT3 blockers, making them preferred choices especially in cases of drug-induced nausea.

  10. DURATION-1: Exenatide Once Weekly Produces Sustained Glycemic Control and Weight Loss Over 52 Weeks

    Buse, John B.; Drucker, Daniel J.; Taylor, Kristin L.; Kim, Terri; Walsh, Brandon; Hu, Hao; Wilhelm, Ken; Trautmann, Michael; Shen, Larry Z.; Porter, Lisa E.; ,

    2010-01-01

    OBJECTIVE In the Diabetes Therapy Utilization: Researching Changes in A1C, Weight and Other Factors Through Intervention with Exenatide Once Weekly (DURATION-1) study, the safety and efficacy of 30 weeks of treatment with the glucagon-like peptide-1 receptor agonist exenatide once weekly (exenatide QW; 2 mg) was compared with exenatide BID in 295 patients with type 2 diabetes. We now report the safety and efficacy of exenatide QW in 1) patients who continued treatment for an additional 22 wee...

  11. A 52-week safety study in cynomolgus macaques for genetically modified rice expressing Cry1Ab/1Ac protein.

    Mao, Jie; Sun, Xing; Cheng, Jian-Hua; Shi, Yong-Jie; Wang, Xin-Zheng; Qin, Jun-Jie; Sang, Zhi-Hong; He, Kun; Xia, Qing

    2016-09-01

    A 52-week feeding study in cynomolgus macaques was carried out to evaluate the safety of Bt rice Huahui 1 (HH1), a transgenic rice line expressing Cry1Ab/1Ac protein. Monkeys were fed a diet with 20% or 60% HH1 rice, 20% or 60% parental rice (Minghui 63, MH63), normal diet, normal diet spiked with purified recombinant Cry1Ab/1Ac fusion protein or bovine serum albumin (BSA) respectively. During the feeding trail, clinical observations were conducted daily, and multiple parameters, including body weight, body temperature, electrocardiogram, hematology, blood biochemistry, serum metabolome and gut microbiome were examined at regular intervals. Upon sacrifice, the organs were weighted, and the macroscopic, microscopic and electron microscopic examinations were performed. The results show no adverse or toxic effects of Bt rice HH1 or Cry1Ab/1Ac fusion protein on monkeys. Therefore, the present 52-week primate feeding study suggests that the transgenic rice containing Cry 1Ab/1Ac is equivalent to its parental rice line MH63. PMID:27338709

  12. Early and Periodic Screening, Diagnosis and Treatment

    U.S. Department of Health & Human Services — The Early and Periodic Screening, Diagnostic and Treatment (EPSDT) benefit provides comprehensive and preventive health care services for children under age 21 who...

  13. Safety and efficacy of teduglutide after 52 weeks of treatment in patients with short bowel intestinal failure

    O'Keefe, Stephen J D; Jeppesen, Palle B; Gilroy, Richard; Pertkiewicz, Marek; Allard, Johane P; Messing, Bernard

    2013-01-01

    Although home parenteral nutrition (PN) can save the lives of patients with massive bowel loss that results in short-bowel syndrome and intestinal failure, quality of life is impaired by PN and its complications. We examined the 12-month tolerability and efficacy of teduglutide to reduce PN...

  14. Characteristics and Experiences of Children and Young People with Severe Intellectual Disabilities and Challenging Behaviour Attending 52-Week Residential Special Schools

    Pilling, N.; McGill, P.; Cooper, V.

    2007-01-01

    Background: This study sought to gather information about the characteristics and experiences of children and young people with severe intellectual disabilities and severe challenging behaviour attending 52-week residential special schools. Method: Staff of nine schools completed postal questionnaires on the characteristics and experiences of 156…

  15. Efficacy and safety characteristics of mometasone furoate/formoterol fumarate fixed-dose combination in subjects with moderate to very severe COPD: findings from pooled analysis of two randomized, 52-week placebo-controlled trials

    Tashkin DP

    2012-02-01

    Full Text Available Donald P Tashkin1, Dennis E Doherty2, Edward Kerwin3, Carlos E Matiz-Bueno4, Barbara Knorr5, Tulin Shekar5, Davis Gates5, Heribert Staudinger51David Geffen School of Medicine at UCLA, Los Angeles, CA, 2Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky, Lexington, KY, 3Clinical Research Institute of Southern Oregon, Medford, OR, USA; 4Fundación Salud Bosque, Bogota, Colombia, 5Merck Sharp & Dohme Corp, Whitehouse Station, NJ, USABackground: The clinical efficacy and safety of a mometasone furoate/formoterol fumarate (MF/F fixed-dose combination formulation administered via a metered-dose inhaler was investigated in patients with moderate to very severe chronic obstructive pulmonary disease (COPD.Methods: Two 52-week, multicenter, double-blind, placebo-controlled trials with identical study designs were conducted in current or ex-smokers (aged ≥40 years, and pooled study results are presented herein. Subjects (n = 2251 were randomized to 26 weeks of twice-daily treatment with MF/F 400/10 µg, MF/F 200/10 µg, MF 400 µg, F 10 µg, or placebo. After the 26-week treatment period, placebo subjects completed the trial and 75% of subjects on active treatment entered a 26-week safety extension. Coprimary efficacy variables were mean changes in forced expiratory volume in one second (FEV1, area under the curve from 0 to 12 hours postdose (AUC0–12 h, and morning predose/trough FEV1 from baseline to the week 13 endpoint. Key secondary efficacy variables were St George’s Respiratory Questionnaire scores, symptom-free nights, time-to-first exacerbation, and partly stable COPD at the week 26 endpoint.Results: In the 26-week treatment period, significantly greater increases in FEV1 AUC0–12 h occurred with MF/F 400/10 versus MF 400 and placebo at the week 13 and week 26 endpoints (P ≤ 0.032. These increases were over three-fold greater with MF/F 400/10 than with MF 400. Also, significantly greater increases in morning

  16. Long-term efficacy and safety of oxycodone–naloxone prolonged release in geriatric patients with moderate-to-severe chronic noncancer pain: a 52-week open-label extension phase study

    Guerriero, Fabio; Roberto, Anna; Greco, Maria Teresa; Sgarlata, Carmelo; Rollone, Marco; Corli, Oscar

    2016-01-01

    Background Two-thirds of older people suffer from chronic pain and finding valid treatment options is essential. In this 1-yearlong investigation, we evaluated the efficacy and safety of prolonged-release oxycodone–naloxone (OXN-PR) in patients aged ≥70 (mean 81.7) years. Methods In this open-label prospective study, patients with moderate-to-severe noncancer chronic pain were prescribed OXN-PR for 1 year. The primary endpoint was the proportion of patients who achieved ≥30% reduction in pain intensity after 52 weeks of treatment, without worsening bowel function. The scheduled visits were at baseline (T0), after 4 weeks (T4), and after 52 weeks (T52). Results Fifty patients completed the study. The primary endpoint was achieved in 78% of patients at T4 and 96% at T52 (P<0.0001). Pain intensity, measured on a 0–10 numerical rating scale, decreased from 6.0 at T0 to 2.8 at T4 and to 1.7 at T52 (P<0.0001). Mean daily dose of oxycodone increased from 10 to 14.4 mg (T4) and finally to 17.4 mg (T52). Bowel Function Index from 35.1 to 28.7 at T52. No changes were observed in cognitive functions (Mini-Mental State Examination evaluation), while daily functioning improved (Barthel Index from 53.1 to 61.0, P<0.0001). The Screener and Opioid Assessment for Patients with Pain-Revised score at 52 weeks was 2.6 (standard deviation 1.6), indicating a low risk of aberrant medication-related behavior. In general, OXN-PR was well tolerated. Conclusion This study of the long-term treatment of chronic pain in a geriatric population with OXN-PR shows satisfying analgesic effects achieved with a stable low daily dose, coupled with a good safety profile and, in particular, with a reduction of constipation, often present during opioid therapy. Our findings support the indications of the American Geriatrics Society, suggesting the use of opioids to treat pain in older people not responsive to acetaminophen or nonsteroidal anti-inflammatory drugs. PMID:27143857

  17. Saxagliptin is non-inferior to glipizide in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: a 52-week randomised controlled trial

    Gause-Nilsson, Ingrid; Göke, Burkhard; Gallwitz, Baptist; Eriksson, Johan; Hellqvist, Asa

    2010-01-01

    Abstract Aim: Assess the efficacy and safety of saxagliptin vs. glipizide, as add-on therapy to metformin in patients with type 2 diabetes mellitus and inadequate glycaemic control on metformin alone. Methods and patients: A total of 858 patients (age ?18 years; glycated haemoglobin [HbA1c] >6.5?10.0%; on stable metformin doses ?1500mg/day) were randomised 1:1 to saxagliptin 5mg/day or glipizide up-titrated as needed from 5?20mg/day for 52 weeks. The primary objective wa...

  18. Long-term efficacy and safety of oxycodone–naloxone prolonged release in geriatric patients with moderate-to-severe chronic noncancer pain: a 52-week open-label extension phase study

    Guerriero F

    2016-04-01

    Full Text Available Fabio Guerriero,1,2 Anna Roberto,3 Maria Teresa Greco,4 Carmelo Sgarlata,1 Marco Rollone,2 Oscar Corli3 1Department of Internal Medicine and Medical Therapy, Section of Geriatrics, University of Pavia, 2Department of Geriatrics, Agency for Elderly People of Pavia, Santa Margherita Institute, Pavia, 3Department of Oncology, Pain and Palliative Care Research Unit, IRCCS-Mario Negri Institute for Pharmacological Research, 4Unit of Medical Statistics, Biometry and Epidemiology GA Maccacaro, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy Background: Two-thirds of older people suffer from chronic pain and finding valid treatment options is essential. In this 1-yearlong investigation, we evaluated the efficacy and safety of prolonged-release oxycodone–naloxone (OXN-PR in patients aged ≥70 (mean 81.7 years.Methods: In this open-label prospective study, patients with moderate-to-severe noncancer chronic pain were prescribed OXN-PR for 1 year. The primary endpoint was the proportion of patients who achieved ≥30% reduction in pain intensity after 52 weeks of treatment, without worsening bowel function. The scheduled visits were at baseline (T0, after 4 weeks (T4, and after 52 weeks (T52.Results: Fifty patients completed the study. The primary endpoint was achieved in 78% of patients at T4 and 96% at T52 (P<0.0001. Pain intensity, measured on a 0–10 numerical rating scale, decreased from 6.0 at T0 to 2.8 at T4 and to 1.7 at T52 (P<0.0001. Mean daily dose of oxycodone increased from 10 to 14.4 mg (T4 and finally to 17.4 mg (T52. Bowel Function Index from 35.1 to 28.7 at T52. No changes were observed in cognitive functions (Mini-Mental State Examination evaluation, while daily functioning improved (Barthel Index from 53.1 to 61.0, P<0.0001. The Screener and Opioid Assessment for Patients with Pain-Revised score at 52 weeks was 2.6 (standard deviation 1.6, indicating a low risk of aberrant medication

  19. Periodically operated bioreactors for the treatment of soils and leachates

    Limited contaminant bioavailability at concentrations above the required cleanup level reduces biodegradation rate and renders solid-phase bioremediation more cost effective than complete treatment in a bioslurry reactor. Slurrying followed by solid-phase bioremediation combines the advantages and minimizes the weaknesses of each treatment method when used alone. Periodic aeration during solid-phase bioremediation has the potential to lower treatment costs relative to continuous aeration. A biological treatment system consisting of slurrying followed by periodic aeration in solid-phase sequencing batch reactors (SP-SBRs) was developed and tested in the laboratory using a silty loam contaminated predominantly with the plasticizer bis(2-ethylhexyl)phthalate (BEHP) or (DEHP) and a silty clay loam contaminated with diesel fuel. The first experiment evaluated the effect of water content and mixing time during slurrying on subsequent treatment in continuously aerated solid-phase bioreactors. The second experiment compared treatment of slurried soil in SP-SBRs using three different periodic aeration strategies with continuous aeration

  20. Surgical treatment for thyrotoxic hypokalemic periodic paralysis: case report

    Lin Yi-Chu

    2012-01-01

    Full Text Available Abstract Thyrotoxic hypokalemic periodic paralysis (THPP is a rare, potentially life-threatening endocrine emergency. It is characterized by recurrent muscle weakness and hypokalemia. Because many THPP patients do not have obvious symptoms and signs of hyperthyroidism, misdiagnosis may occur. The published studies revealed that definitive therapy for THPP is control of hyperthyroidism by medical therapy, radioactive iodine or surgery, but the long-term post-operative follow-up result was not observed. We reported two cases of medically refractory THPP with recurrent paralysis of extremities and hypokalemia, and both were combined with thyroid nodules. Both patients were treated with total thyroidectomy; the pathology revealed that one is Graves' disease with thyroid papillary carcinoma, and the other is adenomatous goiter with papillary hyperplasia. No episode of periodic paralysis was noted and laboratory evaluation revealed normal potassium level during the post-operative follow up. Our experience suggests that total thyroidectomy by experienced surgeon is an appropriate and definite treatment for medically refractory THPP, especially in cases combined with thyroid nodules.

  1. Alveolar proteinosis: diagnosis and treatment over a 10-year period.

    du Bois, R M; McAllister, W A; Branthwaite, M A

    1983-01-01

    Ten years' experience of using bronchoalveolar lavage in the treatment of 10 patients with alveolar proteinosis is reported. The diagnosis was often missed. The interval between onset of symptoms and diagnosis varied from six weeks to six years (median 2 years), so that the start of treatment was often delayed. Some patients experienced severe progressive disability before they had treatment. Whole-lung lavage proved to be a safe, repeatable procedure which provided symptomatic, physiological...

  2. Periodization

    Lorenz, Daniel S.; Reiman, Michael P.; Walker, John C.

    2010-01-01

    Background: Clinicians are constantly faced with the challenge of designing training programs for injured and noninjured athletes that maximize healing and optimize performance. Periodization is a concept of systematic progression—that is, resistance training programs that follow predictable patterns of change in training variables. The strength training literature is abundant with studies comparing periodization schemes on uninjured, trained, and untrained athletes. The rehabilitation litera...

  3. Surgical treatment for thyrotoxic hypokalemic periodic paralysis: case report

    Lin Yi-Chu; Wu Che-Wei; Chen Hui-Chun; Chen Hsiu-Ya; Lu I-Cheng; Tsai Cheng-Jing; Kuo Wen-Rei; Chiang Feng-Yu

    2012-01-01

    Abstract Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare, potentially life-threatening endocrine emergency. It is characterized by recurrent muscle weakness and hypokalemia. Because many THPP patients do not have obvious symptoms and signs of hyperthyroidism, misdiagnosis may occur. The published studies revealed that definitive therapy for THPP is control of hyperthyroidism by medical therapy, radioactive iodine or surgery, but the long-term post-operative follow-up result was not...

  4. Familial gastric cancer: guidelines for diagnosis, treatment and periodic surveillance

    Kluijt, Irma; Sijmons, Rolf H; Hoogerbrugge, Nicoline; Plukker, John T.; de Jong, Daphne; van Krieken, J. Han; van Hillegersberg, Richard; Ligtenberg, Marjolijn; Bleiker, Eveline; Cats, Anemieke

    2012-01-01

    Hereditary diffuse gastric cancer (HDGC) is a relatively rare disorder, with a mutated CDH1 gene as the only known cause. Carriers of a germline mutation in CDH1 have a lifetime risk of > 80% of developing diffuse gastric cancer. As periodic gastric surveillance is of limited value in detecting early stages of HDGC, prophylactic gastrectomy is advised for this patient group. Little is known about other types of familial gastric cancer. The Dutch working group on hereditary gastric cancer has ...

  5. Periodicity in cell dynamics in some mathematical models for the treatment of leukemia

    Halanay, A.

    2012-11-01

    A model for the evolution of short-term hematopoietic stem cells and of leukocytes in leucemia under periodic treatment is introduced. It consists of a system of periodic delay differential equations and takes into consideration the asymmetric division. A guiding function is used, together with a theorem of Krasnoselskii, to prove the existence of a strictly positive periodic solution and its stability is investigated.

  6. Fluctuations induced extinction and stochastic resonance effect in a model of tumor growth with periodic treatment

    Li Dongxi, E-mail: lidongxi@mail.nwpu.edu.c [Department of Applied Mathematics, Northwestern Polytechnical University, Xi' an 710072 (China); Xu Wei; Guo, Yongfeng; Xu Yong [Department of Applied Mathematics, Northwestern Polytechnical University, Xi' an 710072 (China)

    2011-01-31

    We investigate a stochastic model of tumor growth derived from the catalytic Michaelis-Menten reaction with positional and environmental fluctuations under subthreshold periodic treatment. Firstly, the influences of environmental fluctuations on the treatable stage are analyzed numerically. Applying the standard theory of stochastic resonance derived from the two-state approach, we derive the signal-to-noise ratio (SNR) analytically, which is used to measure the stochastic resonance phenomenon. It is found that the weak environmental fluctuations could induce the extinction of tumor cells in the subthreshold periodic treatment. The positional stability is better in favor of the treatment of the tumor cells. Besides, the appropriate and feasible treatment intensity and the treatment cycle should be highlighted considered in the treatment of tumor cells.

  7. Fluctuations induced extinction and stochastic resonance effect in a model of tumor growth with periodic treatment

    We investigate a stochastic model of tumor growth derived from the catalytic Michaelis-Menten reaction with positional and environmental fluctuations under subthreshold periodic treatment. Firstly, the influences of environmental fluctuations on the treatable stage are analyzed numerically. Applying the standard theory of stochastic resonance derived from the two-state approach, we derive the signal-to-noise ratio (SNR) analytically, which is used to measure the stochastic resonance phenomenon. It is found that the weak environmental fluctuations could induce the extinction of tumor cells in the subthreshold periodic treatment. The positional stability is better in favor of the treatment of the tumor cells. Besides, the appropriate and feasible treatment intensity and the treatment cycle should be highlighted considered in the treatment of tumor cells.

  8. High-dose-rate interstitial brachytherapy for gynecologic malignancies. Dosimetric changes during treatment period

    The purpose of this study was to overcome cranio-caudal needle displacement in pelvic high-dose-rate interstitial brachytherapy (HDRIB), we have been utilizing a fullystretched elastic tape to thrust the template into the perineum. The purpose of the current study was to evaluate dosimetric changes during the treatment period using this thrusting method, and to explore reproducible planning methods based on the results of the dosimetric changes. Twenty-nine patients with gynecologic malignancies were treated with HDRIB at the Cancer Institute Hospital. Pre-treatment and post-treatment computed tomography (CT) scans were acquired and a virtual plan for post-treatment CT was produced by applying the dwell positions/times of the original plan. For the post-treatment plan, D90 for the clinical target volume (CTV) and D2cc for the rectum and bladder were assessed and compared with that for the original plan. Cranio-caudal needle displacement relative to CTV during treatment period was only 0.7±1.9 mm. The mean D90 values for the CTV in the pre- and post-treatment plans were stable (6.8 Gy vs. 6.8 Gy) and the post-treatment/pre-treatment D90 ratio was 1.00±0.08. The post-/pre-treatment D2cc ratio was 1.14±0.22 and the mean D2cc for the rectum increased for the post-treatment plan (5.4 Gy vs. 6.1 Gy), especially when parametrial infiltration was present. The mean D2cc for the bladder was stable (6.3 Gy vs. 6.6 Gy) and the ratio was 1.06±0.20. Our thrusting method achieved a stable D90 for the CTV, in contrast to previous prostate HDRIB reports displaying reductions of 35-40% for D90 during the treatment period. (author)

  9. Efficacy analysis of 131I in treatment of hyperthyroidism with periodic paralysis

    To evaluate therapeutic effect of 131I in thyrotoxic periodic paralysis (TPP), the serum TT3, TT4, FT3 and FT4 in TPP Patients before and after treatment with 131I were detected. The results showed that the serum potassium was decreased and serum TT3, TT4, FT3 and FT4 in those patients were increased. The cure rates in 8 TPP were 75% and 100% after 6 and 12 months treatment with 131I respectively. 131I treatment was a good therapeutic effect with short course and high cure rate. 131I is the first choice for the treatment of patients with TPP. (authors)

  10. Proliferation enhancement of budding yeast and mammalian cells with periodic oxygen radical treatment

    Mori, Yosuke; Kobayashi, Jun; Murata, Tomiyasu; Hahizume, Hiroshi; Hori, Masaru; Ito, Masafumi

    2015-09-01

    Recently, nonequilibrium atmospheric-pressure plasmas have been intensively studied for biological applications. However, the each effect of species in plasmas to biological tissue has not been clarified yet because various factors exist in the plasmas. Accordingly, we have studied effects of atomic oxygen dose on cell growth such as budding yeast and mouse NIH3T3 fibroblasts of mammalian cells. Both of cells were suspended with PBS, and treated using oxygen radical source. In order to prevent the radicals from reacting with the ambient air, the treatment region was surrounded by a plastic cover and purged with Ar. The proliferative effect of 15 % was observed at the O3Pj dose of around 1 . 0 ×1017 cm-3 in NIH3T3 cells as well as in yeast cells. Moreover, periodic oxygen treatment enhanced the effect in budding yeast cells. The best interval of periodic oxygen radical treatment was around 2 hours, which is almost the same period as that of their cell cycle. With the optimum interval time, we have investigated the effect of the number of the treatments. As the number of treatments increases, the growth rate of budding yeast cells was gradually enhanced and saturated at thrice treatments. This work was partly supported by JSPS KAKENHI Grant Numbers 26286072 and project for promoting Research Center in Meijo University.

  11. Analysis of incidence and treatment of pneumothorax in five-year period in Kragujevac

    Milisavljević Slobodan

    2012-01-01

    Full Text Available Introduction. Pneumothorax is a common clinical problem in thoracic surgery. Leading professional associations have adopted a number of guidelines and recommendations for the treatment of pneumothorax, but their clinical use is often insufficient. This study was aimed at analyzing the incidence of pneumothorax, profile of patients and surgical treatment of pneumothorax at the Clinical Center Kragujevac, in a five-year period. Material an methods. This retrospective, non-interventional study used data collected from the medical records and operative protocol of the Department of Thoracic Surgery, Clinical Centre Kragujevac in a fiveyear period. All data were statistically analyzed. Results. In the observed period, 492 patients with diagnosis of pneumothorax were hospitalized. The majority of patients were treated in 2009 (140, and the fewest in 2005 (68. Four-fifths of patients were male. Primary spontaneous pneumothorax was found in 25% and traumatic pneumothorax in 50%. Most patients were aged 21-30 years (83. The number of cases of secondary spontaneous and traumatic pneumothorax increased with the age of patients and the number of cases of primary and recurrent spontaneous pneumothorax decreased with their age. Drainage as a method of treatment was prevalent in all types of pneumothorax (p < 0.01. Conclusion. The results of study show similarities with other studies regarding both the incidence of certain forms of pneumothorax and the gender-age profile of patients and their treatment, taking into account the observed period and the target population.

  12. Application of pulse-periodical mode for improvement of laser treatment efficiency

    Apollonov, V. V.; O. G. Devoino; A. S. Kalinichenko

    2014-01-01

    The purpose of the paper is to estimate an application of pulse-periodical mode for improvement of laser treatment efficiency. Laser technologies have been widely used in the processes of material treatment with the purpose to provide them the required surface properties and also for high accuracy cutting of sheet materials. Application of complex treatment is of great interest and especially when it is used for worn-out surfaces with formation of a coating by gas-flame laying of powder mixtu...

  13. Effects of mometasone furoate/formoterol fumarate fixed-dose combination formulation on chronic obstructive pulmonary disease (COPD: results from a 52-week Phase III trial in subjects with moderate-to-very severe COPD

    Doherty DE

    2012-02-01

    Full Text Available Dennis E Doherty1, Donald P Tashkin2, Edward Kerwin3, Barbara A Knorr4, Tulin Shekar4, Sibabrata Banerjee4, Heribert Staudinger41Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky, Lexington, KY, 2David Geffen School of Medicine at UCLA, Los Angeles, CA, 3Clinical Research Institute of Southern Oregon, Medford, OR, 4Merck Sharp & Dohme Corp, Whitehouse Station, NJ, USARationale: The purpose of this study was to investigate the clinical efficacy and safety of a fixed-dose combination of mometasone furoate/formoterol fumarate (MF/F administered via a metered-dose inhaler in subjects with moderate-to-very severe chronic obstructive pulmonary disease (COPD.Methods: This multicenter, double-blind, placebo-controlled trial had a 26-week treatment period and a 26-week safety extension. Subjects (n = 1196, at least 40 years old, were current or ex-smokers randomized to twice-daily inhaled MF/F 400/10 µg, MF/F 200/10 µg, MF 400 µg, F 10 µg, or placebo. The trial’s co-primary endpoints were mean changes from baseline, as area under the curve (AUC, in forced expiratory volume (FEV1 over 0–12 hours (AUC0-12 h FEV1 with MF/F versus MF, and in morning (AM pre-dose (trough FEV1 with MF/F versus F after 13 weeks of treatment. Key secondary endpoints were the effects of MF/F on respiratory health status using the Saint George’s Respiratory Questionnaire (SGRQ, symptom-free nights, partly stable COPD at 26 weeks, and time to first COPD exacerbation.Results: The largest improvements in AUC0-12 h FEV1 were observed with MF/F 400/10 µg and MF/F 200/10 µg. Serial spirometry results demonstrated that bronchodilator effects with MF/F occurred rapidly (within 5 minutes, persisted for 12 hours after dosing, and were sustained over the 26-week treatment period. Similar findings were observed for AM pre-dose FEV1, for which effects were further investigated, excluding subjects whose AM FEV1 data were incorrectly collected after 2

  14. Efficacy and safety of a fixed-dose combination of mometasone furoate and formoterol fumarate in subjects with moderate to very severe COPD: results from a 52-week Phase III trial

    Tashkin DP

    2012-02-01

    Full Text Available Donald P Tashkin1, Dennis E Doherty2, Edward Kerwin3, Carlos E Matiz-Bueno4, Barbara Knorr5, Tulin Shekar5, Sibabrata Banerjee5, Heribert Staudinger51David Geffen School of Medicine at UCLA, Los Angeles, CA, 2Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky, Lexington, KY, 3Clinical Research Institute of Southern Oregon, Medford, OR USA; 4Fundación Salud Bosque, Bogota, Colombia; 5Merck Sharp & Dohme Corp, Whitehouse Station, NJ USABackground: A clinical trial of mometasone furoate/formoterol fumarate (MF/F administered via a metered-dose inhaler in subjects with moderate to very severe chronic obstructive pulmonary disease (COPD investigated the efficacy and safety of a fixed-dose combination of MF/F.Methods: This multicenter, double-blind, placebo-controlled trial had a 26-week treatment period and a 26-week safety extension. Subjects (n = 1055; ≥40 years were current or ex-smokers randomized to twice-daily treatment with inhaled MF/F 400/10 µg, MF/F 200/10 µg, MF 400 µg, F 10 µg, or placebo. The coprimary endpoints of the trial were mean changes from baseline in forced expiratory volume in 1 second (FEV1 over 0–12 hours (AUC0–12 FEV1 with MF/F versus MF, and in morning predose FEV1 with MF/F versus F. Key secondary endpoints were quality of life (Saint George’s Respiratory Questionnaire [SGRQ], symptom-free nights, and partly stable COPD at 26 weeks, as well as time to first COPD exacerbation.Results: Significant improvements in FEV1 AUC0–12 occurred at endpoint with MF/F 400/10 and MF/F 200/10 versus MF 400 (P ≤ 0.007. Significant bronchodilation occurred in 5 minutes with MF/F, and serial spirometry demonstrated sustained FEV1 improvements with MF/F over the treatment period. Significant improvements in morning predose FEV1 occurred with both MF/F doses, and these effects were further investigated by excluding results for subjects whose morning FEV1 data were collected >2 days after the last

  15. Combination quetiapine therapy in the long-term treatment of patients with bipolar I disorder

    Calabrese JR

    2005-07-01

    Full Text Available Abstract Objective Determine the long-term effectiveness of quetiapine in combination with standard treatments in preventing relapses for patients with bipolar I disorders Method Twenty-one outpatients with type I bipolar disorder who had inadequate responses to ongoing standard therapies were treated with add-on quetiapine in an open-label study. The quetiapine dose was increased until clinical response occurred. Illness response was assessed using the Clinical Global Impression (CGI scale. Relapse rates before and during quetiapine treatment were compared by calculating incidence risk ratios. Results Quetiapine was added to ongoing standard therapy for 26 to 78 weeks. Thirteen patients received combination therapy for at least 52 weeks. The mean quetiapine dose received was 518 ± 244 mg/day. There were highly significant improvements in overall relapse rate, manic/mixed relapse rate, and depression relapse rate in the period during quetiapine treatment compared with the period before quetiapine was initiated. The calculated relative risk of relapse in the absence of quetiapine treatment was 2.9 overall (95% confidence interval, 1.5~5.6, 3.3 for manic/mixed relapse (95% confidence interval, 1.5~7.1, and 2.4 for depressive relapse (95% confidence interval, 1.3~4.4. The mean Clinical Global Impression scores improved significantly from baseline during 26 weeks of quetiapine treatment in 21 patients (p = 0.002 and remained significantly better during a 52-week treatment period in 13 patients (p = 0.036. Conclusion Long-term treatment with quetiapine combination therapy reduced the probability of manic/mixed and depressive relapses and improved symptoms in patients with bipolar I disorder who had inadequate responses to ongoing standard treatment.

  16. APPLICATION OF PULSE-PERIODICAL MODE FOR IMPROVEMENT OF LASER TREATMENT EFFICIENCY

    V. V. Apollonov

    2014-01-01

    Full Text Available The purpose of the paper is to estimate an application of pulse-periodical mode for improvement of laser treatment efficiency. Laser technologies have been widely used in the processes of material treatment with the purpose to provide them the required surface properties and also for high accuracy cutting of sheet materials. Application of complex treatment is of great interest and especially when it is used for worn-out surfaces with formation of a coating by gas-flame laying of powder mixture of specific composition and subsequent laser fusion.Increase of laser unit capacity is very important task for higher efficiency of laser technology application in mechanical engineering. Nowadays technological processes using lasers with high average power (more than 100 W have been applying only sources that are working in two modes, namely: continuous and pulse- periodical (P-P with pulse repetition rate from some units to several hundred hertz and pulse duration within dozens to hundreds of microseconds and even within milliseconds. On the other hand, in some cases shielding effect of plasma cloud formed during laser alloying, cladding or welding reduces the efficiency of laser treatment up to 50 % depending on plasma composition and laser beam length. High frequency P-P laser systems with high average power working in mode of Q-factor modulation allow to realize principally other mechanism of irradiation interaction with materials that is an ablation. In this case it is possible to provide local energy release both in space and time.The performed analysis has revealed that P-P mode of laser operation for a majority of treatment processes is much better and more efficient from energetic point of view in comparison with the continuous mode. On the basis of the developments it is possible to make a conclusion that there is a possibility to create laser systems working in high frequency P-P mode with high average power above hundreds watt.

  17. Meaning of leprosy for people who have experienced treatment during the sulfonic and multidrug therapy periods

    Karen da Silva Santos

    2015-08-01

    Full Text Available AbstractObjective: to analyze the meanings of leprosy for people treated during the sulfonic and multidrug therapy periods.Method: qualitative nature study based on the Vigotski's historical-cultural approach, which guided the production and analysis of data. It included eight respondents who have had leprosy and were submitted to sulfonic and multidrug therapy treatments. The participants are also members of the Movement for Reintegration of People Affected by Leprosy.Results: the meanings were organized into three meaning cores: spots on the body: something is out of order; leprosy or hanseniasis? and leprosy from the inclusion in the Movement for Reintegration of People Affected by Leprosy.Conclusion: the meanings of leprosy for people submitted to both regimens point to a complex construction thereof, indicating differences and similarities in both treatments. Health professionals may contribute to the change of the meanings, since these are socially constructed and the changes are continuous.

  18. Evaluating the Efficacy of Primary Treatment for Graves’ Disease Complicated by Thyrotoxic Periodic Paralysis

    Rita Yuk-Kwan Chang

    2014-01-01

    Full Text Available Objective. Thyrotoxic periodic paralysis (TPP is a potentially life-threatening complication of Graves’ disease (GD. The present study compared the long-term efficacy of antithyroid drugs (ATD, radioactive iodine (RAI, and surgery in GD/TPP. Methods. Sixteen patients with GD/TPP were followed over a 14-year period. ATD was generally prescribed upfront for 12–18 months before RAI or surgery was considered. Outcomes such as thyrotoxic or TPP relapses were compared between the three modalities. Results. Eight (50.0% patients had ATD alone, 4 (25.0% had RAI, and 4 (25.0% had surgery as primary treatment. Despite being able to withdraw ATD in all 8 patients for 37.5 (22–247 months, all subsequently developed thyrotoxic relapses and 4 (50.0% had ≥1 TPP relapses. Of the four patients who had RAI, two (50% developed thyrotoxic relapse after 12 and 29 months, respectively, and two (50.0% became hypothyroid. The median required RAI dose to render hypothyroidism was 550 (350–700 MBq. Of the 4 patients who underwent surgery, none developed relapses but all became hypothyroid. Conclusion. To minimize future relapses, more definitive primary treatment such as RAI or surgery is preferred over ATD alone. If RAI is chosen over surgery, a higher dose (>550 MBq is recommended.

  19. Obsessive-compulsive disorder in the perinatal period: epidemiology, phenomenology, pathogenesis, and treatment

    Álvaro Frías

    2015-01-01

    Full Text Available The aim of this review is to describe the main theoretical findings and research conclusions about obsessive-compulsive disorder (OCD in the perinatal period. On one hand, epidemiological studies show that the risk of OCD onset and/or exacerbation could increase in this period, particularly in the puerperium. Phenomenologically, in this stage aggressive and contamination obsessions are very common and are related to the fetus or newborn. On the other hand, regarding OCD pathogenesis in this period, there is indirect evidence to suggest the participation of neuroendocrine (e.g. female gonadal steroids and oxytocin and cognitive behavioural variables (e.g. hyper-responsibility, threat overestimation, and mental control. In terms of research, more empirical studies are needed to contrast these specific vulnerability factors. Moreover, no empirically validated psychotherapeutic treatments (controlled trials adapted to this OCD sub-group were found, although some studies highlight the role of cognitive behavioural therapy (CBT as an effective intervention in the context of selective primary prevention.

  20. [Anemia and its treatment with peroral anti-anemia agents in women during the postpartum period].

    Mára, M; Eretová, V; Zivný, J; Kvasnicka, J; Umlaufová, A; Márová, E

    1999-06-01

    The prevalence of anaemia during pregnancy and post partum is according to the literature and many years clinical experience high. In the submitted work we investigated the incidence of sideropenic anaemia in women during the first three months after a spontaneous delivery, changes of clinical and laboratory indicators of anaemia during this period and the possible effect exerted by administration of iron and iron plus folic acid resp. Ninety pregnant women in the 35th to 39th week of pregnancy were at random divided into three equally sized groups and the following were assessed: haemogram, indicators of iron reserves, serum concentrations of folic acid, vitamin B12, erythropoetin and soluble transferrin receptor, liver tests, total protein + electrophoresis, acute stage proteins. In the first group (T) the women were given, starting on the 4th day after delivery 1 tablet of Tardyferon per day for two months. To the second group (F) for an equal period 1 tablet of Tardyferon Fol per day was administered. Women in the control group (K) had no medication. In the investigation women with medium and severe pregnancy anaemia were not included nor women taking during pregnancy or previously iron preparations or those treated in the past by blood transfusion. After spontaneous delivery (women who had Caesarean section or forceps delivery were eliminated from the study) the women were subjected to the same examinations as before delivery. These examinations were made on the fourth day after delivery and then after monthly intervals for a period of three months. At the same time the subjective condition of the mothers was evaluated after delivery, focused on the development of symptoms typical for anaemia and the possible effect of administered treatment. The investigation was completed by 60 women. During treatment no allergic or other serious side-reactions to the administered drugs calling for discontinuation of treatment were recorded. The results of the investigation

  1. Induction of ovarian activity in Bulgarian Murrah buffaloes by hormonal treatment in the early postpartum period

    Stanimir A Yotov; Anatoli S Atanasov; Yordanka Y Ilieva

    2013-01-01

    Objective: To determine the possibilities for induction of ovarian activity in Bulgarian Murrah buffaloes by hormonal treatment in the early postpartum period. Methods: Twenty six clinically healthy animals, weighing 480-520 kg, 3-5 years of age, with normal parturition, without clinical signs of endometritis during the entire experimental period were divided into 2 groups: control (n=10) and experimental (n=16). Primiparous and multiparous buffaloes were proportionally allotted into both groups. By 5, 21, and 28 postpartum days, control animals were intramuscularly treated with 2 mL physiological saline, whereas experimental buffaloes received 500 mg PGF2αby the 5th postpartum day, 100 μg GnRH by the 21st postpartum day and a second prostaglandin dose 7 days later. All buffaloes were submitted to transrectal ultrasound examination on days 5, 21 and 28 after calving. Evaluation of ovarian activity was made on the basis of follicle type and detection of a newly formed corpus luteum. The percentage of animals with small, medium or dominant follicle and corpus luteum after either spontaneous or induced ovulation was determined. Insemination management included introduction of two proven fertile bulls into the herd at the start of the treatment. Pregnancy ultrasound checks were performed on postpartum days 58, 68, 120 and 150. The proportion of buffaloes with clinical signs of spontaneous or induced oestrus until the 35th postpartum day, pregnancy rates by the 35th and 90th postpartum days and service periods 90 days were registered. Results: On the 5th day after calving, small follicles were predominating in the ovaries of buffaloes from both groups. Similar findings were established on the 21st day in the control group, whereas the share of experimental buffaloes with small follicles was significantly (P<0.01) lower. By the 21st day, there were no medium follicles in untreated animals, while in hormonally treated ones they were found out in 25% of cases. The

  2. Influence of winter wheat seed treatment by laser on vegetation period duration and harvest index of grain

    Influence of winter wheat seed stimulation by laser (cv. Radika) on the stages of development, duration of vegetation period and harvest index of grain was investigated. For dates of development stages advancing to heading, between cv. Radika and it's laser treatment weren't noticed significant differences. Noticable differences appear in stages of kernel filling and for duration of vegetation period. Treatments by laser were earlier in maturing from standard for 2-6 days depending of treatment and year. The harvest index of grain at laser treatments was significantly higher and depended from the conditions of year, too

  3. Determination of Rifaximin Treatment Period According to Lactulose Breath Test Values in Nonconstipated Irritable Bowel Syndrome Subjects

    Bae, Suhyun; Lee, Kwang Jae; Kim, Young-Sang; Kim, Kyu-Nam

    2015-01-01

    Small intestinal bacterial overgrowth (SIBO) can partly explain irritable bowel syndrome (IBS), and rifaximin has been observed to improve abdominal symptoms in nonconstipated IBS patients. However, there are few reports on the association of the rifaximin treatment periods with the results of a lactulose breath test (LBT). Therefore, we performed a retrospective review of patient charts to investigate the relation between the rifaximin treatment periods with LBT results in nonconstipated IBS...

  4. The Effectiveness of Life Skills Training on Enhancement of Self-Esteem and Marital Satisfaction among Addicts in Treatment Period

    R Nooripour; A ZadeMohammadi; M Dastras; M Sargolzai

    2014-01-01

    Objective: This study has been done to determine the impact of life skills training on enhancement of self-esteem and marital satisfaction among addicts in treatment period. Method: The research design was semi experimental pretest-posttest with witness group. For each group 12men addicts in treatment period in Qazvin city were selected by available sampling. Rosenberg self-esteem and Enrich marital satisfaction questionnaires were administered among selected samples. Training workshop was co...

  5. Interleukin-1 antagonists in the treatment of autoinflammatory syndromes, including cryopyrin-associated periodic syndrome

    Pierre Quartier

    2011-01-01

    Full Text Available Pierre QuartierUnité d'Immunologie-Hématologie et Rhumatologie pédiatriques, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, FranceAbstract: Cryopyrin-associated periodic syndrome (CAPS include a group of rare autoinflammatory disorders, the spectrum of which ranges from the mildest form, ie, familial cold autoinflammatory syndrome to more severe phenotypes, ie, Muckle-Wells syndrome, and chronic infantile neurological cutaneous and articular syndrome, also known as neonatal-onset multisystem inflammatory disease. Three interleukin (IL-1 antagonists have been tested in adults and children with CAPS, ie, anakinra, a recombinant homolog of the human IL-1 receptor antagonist; rilonacept, a fusion protein comprising the extracellular domains of IL-1 receptor I and the IL-1 adaptor protein, IL-1RAcP, attached to a human immunoglobulin G molecule; and canakinumab, the anti-IL-1β monoclonal antibody. Following rapid clinical development, rilonacept and canakinumab were approved by both the US Food and Drug Administration and the European Medicines Agency for use in adults and children. This review describes how the study of CAPS has helped us to understand better the way the innate immune system works, the pathogenesis of autoinflammatory syndromes, and the key role of IL-1. It also reviews the effects of IL-1 blockade in CAPS and other disorders, in particular systemic juvenile idiopathic arthritis, adult-onset Still's disease, and gout. Finally, this review covers some issues addressed by very recent and ongoing work regarding treatment indications, from orphan diseases to common disorders, continuous versus intermittent treatment, the pharmacokinetics, pharmacodynamics, and optimal dosages of the different drugs, as well as the need for Phase IV trials, exhaustive registries, and long-term follow-up of several patient cohorts.Keywords: inflammation, interleukin-1, cytokines, treatment

  6. Large-Sample Confidence Intervals for the Treatment Difference in a Two-Period Crossover Trial, Utilizing Prior Information

    Kabaila, Paul; Giri, Khageswor

    2008-01-01

    Consider a two-treatment, two-period crossover trial, with responses that are continuous random variables. We find a large-sample frequentist 1-alpha confidence interval for the treatment difference that utilizes the uncertain prior information that there is no differential carryover effect.

  7. Interleukin-1β inhibitors for the treatment of cryopyrin-associated periodic syndrome

    Eugen Dhimolea

    2011-01-01

    Full Text Available Eugen DhimoleaTufts University School of Medicine, Boston, MA, USAAbstract: Cryopyrin-associated periodic syndrome (CAPS comprises a group of rare, but severe, inherited autoinflammatory disorders associated with aberrant secretion of interleukin (IL-1. These distinct conditions of autoinflammatory origin include Muckle–Wells syndrome, familial cold autoinflammatory syndrome, and neonatal-onset multisystem inflammatory disease (NOMID, which is also referred to as chronic infantile neurologic cutaneous and articular syndrome. Recently, this group of diseases has been associated with mutations in the NLRP3 gene that encodes for the protein cryopyrin, a component of the inflammasome complex that regulates the maturation and secretion of inflammatory cytokine IL-1β. Immune cells from patients with NOMID secrete higher levels of active IL-1β compared with monocytes from healthy subjects. Overproduction of IL-1 is believed to promote aberrant inflammatory response in CAPS patients. Evidence supporting the clinical value of IL-1β in CAPS has been provided from the complete response of patients after treatment with IL-1 blocking agents.Keywords: CAPS, IL-1β, NLRP3, canakinumab, anakinra

  8. Monitoring noise-resonant effects in cancer growth influenced by spontaneous fluctuations and periodic treatment

    Fiasconaro, Alessandro; Spagnolo, Bernardo; Gudowska-Nowak, Ewa

    2007-01-01

    In the paper we investigate a mathematical model describing the growth of tumor in the presence of immune response of a host organism. The dynamics of tumour and immune cells is based on the generic Michaelis-Menten kinetics describing interaction and competition between the tumour and the immune system. The appropriate phenomenological equation modeling cell-mediated immune surveillance against cancer is of the predator-prey form and within a given choice of parameters exhibits bistability. Under the influence of spontaneous weak fluctuations, the model may be analyzed in terms of a stochastic differential equation bearing the form of an overdamped Langevin-like dynamics in the external quasi-potential represented by a double well. We analyze properties of the system within the range of parameters for which the potential wells are of the same depth and when the additional perturbation describing a periodic treatment is insufficient to overcome the barrier height and to cause cancer extinction. In this case t...

  9. Determination of rifaximin treatment period according to lactulose breath test values in nonconstipated irritable bowel syndrome subjects.

    Bae, Suhyun; Lee, Kwang Jae; Kim, Young-Sang; Kim, Kyu-Nam

    2015-06-01

    Small intestinal bacterial overgrowth (SIBO) can partly explain irritable bowel syndrome (IBS), and rifaximin has been observed to improve abdominal symptoms in nonconstipated IBS patients. However, there are few reports on the association of the rifaximin treatment periods with the results of a lactulose breath test (LBT). Therefore, we performed a retrospective review of patient charts to investigate the relation between the rifaximin treatment periods with LBT results in nonconstipated IBS patients. We also evaluated the time to achieve a symptomatic improvement in the IBS patients as compared to the changes in the LBT. We reviewed the charts for patients who showed IBS symptoms with documented positive results for LBT during their initial visit and who had a follow-up LBT after treatment with rifaximin. The LBT values were compared to the subjects' symptom scores. A total of 102 subjects had a follow-up LBT to assess LBT normalization. The subjects were divided into groups according to treatment periods of 4 weeks (n = 36), 8 weeks (n = 43), and 12 weeks (n = 23). The groups with a longer treatment exhibited an increase in the hydrogen gas value at 90 min and its sum during 90 min at the initial LBT. There were significant differences in hydrogen gas value at 90 min and in its sum during 90 min at the initial LBT between the groups treated for 4 and 12 weeks. The most significant treatment response was observed during the first 4 weeks for all treatment groups. Symptomatic improvement occurred earlier than LBT normalization in the treatment period over 4 weeks. The results indicate that different rifaximin treatment periods are needed in accordance with LBT levels to effectively eradicate SIBO. PMID:26028929

  10. Sleep-stage sequencing of sleep-onset REM periods in MSLT predicts treatment response in patients with narcolepsy.

    Drakatos, Panagis; Patel, Kishankumar; Thakrar, Chiraag; Williams, Adrian J; Kent, Brian D; Leschziner, Guy D

    2016-04-01

    Current treatment recommendations for narcolepsy suggest that modafinil should be used as a first-line treatment ahead of conventional stimulants or sodium oxybate. In this study, performed in a tertiary sleep disorders centre, treatment responses were examined following these recommendations, and the ability of sleep-stage sequencing of sleep-onset rapid eye movement periods in the multiple sleep latency test to predict treatment response. Over a 3.5-year period, 255 patients were retrospectively identified in the authors' database as patients diagnosed with narcolepsy, type 1 (with cataplexy) or type 2 (without) using clinical and polysomnographic criteria. Eligible patients were examined in detail, sleep study data were abstracted and sleep-stage sequencing of sleep-onset rapid eye movement periods were analysed. Response to treatment was graded utilizing an internally developed scale. Seventy-five patients were included (39% males). Forty (53%) were diagnosed with type 1 narcolepsy with a mean follow-up of 2.37 ± 1.35 years. Ninety-seven percent of the patients were initially started on modafinil, and overall 59% reported complete response on the last follow-up. Twenty-nine patients (39%) had the sequence of sleep stage 1 or wake to rapid eye movement in all of their sleep-onset rapid eye movement periods, with most of these diagnosed as narcolepsy type 1 (72%). The presence of this specific sleep-stage sequence in all sleep-onset rapid eye movement periods was associated with worse treatment response (P = 0.0023). Sleep-stage sequence analysis of sleep-onset rapid eye movement periods in the multiple sleep latency test may aid the prediction of treatment response in narcoleptics and provide a useful prognostic tool in clinical practice, above and beyond their classification as narcolepsy type 1 or 2. PMID:26541241

  11. ANALYSIS OF RANGE CONDITIONS OF CHILDREN WITH SPEECH DIFFICULTIES WITH SPEECH THERAPY TREATMENT AT PRE-SCHOOL PERIOD

    V. MIRAKOVSKA

    1997-12-01

    Full Text Available An analysis for range of children with speech difficulties in their development with speech therapy treatment is made for a period of 3 years ( 1993-1996 in the Institute for hearing, speech and voice in Skopje. The obtained results from the analysis show that “ for the time the children have to go to school, parent’s interest in their children’s speech is increased. About 90 % of the children ranged with speech therapy treatment, in that period they were at 5-7 years of age, and that shows that a part of the utmost period for development of the speech is missed.Also a great number of children with speech difficulties in their development were not ranged with speech therapy treatment. The reasons for that are the late directing of children, the social and cultural factor, economic condition of the family.

  12. Diarrheal Disease and its Treatment among Brazilian Children: Stagnation and Progress over a Ten-Year Period

    Narayan Sastry; Sarah Burgard

    2002-01-01

    In this paper, the authors examine trends and differentials in diarrhea prevalence and treatment in Brazil between 1986 and 1996. The results indicate that there was a very modest decline in diarrhea prevalence in Brazil over this ten year period. However, treatment with oral rehydration therapy (ORT) increased greatly. The rise in ORT use clearly did not reduce the prevalence of diarrhea. It suggests, however, that the focus on therapeutic care may have occurred at the cost of preventive car...

  13. Period of remission after treatment with UVA-1 in sclerodermic skin diseases.

    Kroft, E.B.M.; Kerkhof, P.C.M. van de; Gerritsen, M.J.P.; Jong, E.M.G.J. de

    2008-01-01

    BACKGROUND: Sclerodermic skin diseases can cause severe morbidity and disability. UVA-1 has shown to be an effective therapy for sclerodermic skin diseases. However, the period of remission in these patients is not clear. In this study, the effect and remission period of UVA-1 phototherapy in variou

  14. Use of antidepressants in the treatment of major depressive disorder in primary care during a period of economic crisis

    Sicras-Mainar A

    2015-12-01

    Full Text Available Antoni Sicras-Mainar,1 Ruth Navarro-Artieda2 1Research Unit, Badalona Serveis Assistencials SA, 2Medical Documentation Unit, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain Objective: To describe antidepressant (AD use in the treatment of major depressive disorder during a period of economic crisis.Patients and methods: This was a retrospective, observational study using population-based databases. Two periods were considered: 1 2008–2009, precrisis, and 2 2012–2013, economic crisis. Certain inclusion/exclusion criteria were taken into account for the study (initiation of AD treatment. Patients were followed up for 12 months. The main measures were use (defined daily doses, epidemiologic measures, strategies used and treatment persistence, referrals, and use of resources. Statistical significance was set at P<0.05.Results: In the precrisis period, 3,662 patients were enrolled, and 5,722 were enrolled in the period of economic crisis. Average age was 58.8 years and 65.4% were women. Comparing the two periods, major depressive disorder prevalence was 5.4% vs 8.1%, P<0.001. During the period of economic crisis, AD use rose by 35.2% and drug expenditures decreased by 38.7%. Defined daily dose per patient per day was 10.0 mg vs 13.5 mg, respectively, P<0.001. At 12-month follow-up, the majority of patients (60.8% discontinued the treatment or continued on the same medication as before, and in 23.3% a change of AD was made.Conclusion: Primary health care professionals are highly involved in the management of the illness; in addition, during the period of economic crisis, patients with major depressive disorder showed higher rates of prevalence of the illness, with increased use of AD drugs. Keywords: consumption, antidepressants, economic crisis

  15. Short and long period optimization of drug doses in the treatment of AIDS

    MARCO A. L. CAETANO

    2002-09-01

    Full Text Available Numerical optimization techniques are useful in solving problems of computing the best inputs for systems described by mathematical models and when the objectives can be stated in a quantitative form. This work concerns the problem of optimizing the drug doses in the treatment of AIDS in terms of achieving a balance between the therapeutic response and the side effects. A mathematical model describing the dynamics of HIV viruses and CD4 cells is used to compute the short term optimal drug doses in the treatments of patients with AIDS by a direct method of optimization using a cost function of Bolza type. The model parameters were fitted to actual published clinical data. In order to simplify the numerical procedures, the control law is expressed as a series and the sub-optimal control is obtained by truncating the higher terms. When the patient reaches a clinically satisfactory state, the LQR - Linear Quadratic Regulator technique is used to determine the long period maintenance doses for the drugs. The doses computed using the LQR technique tend to be smaller than equivalent constant-dose therapy in terms of increase in the counts of CD4+T cells and reduction of the density of free viruses.Técnicas de otimização numérica são úteis na solução de problemas de determinação da melhor entrada para sistemas descritos por modelos matemáticos e cujos objetivos podem ser expressos de uma maneira quantitativa. Este trabalho aborda o problema de otimizar as dosagens dos medicamentos no tratamento da AIDS em termos de um balanço entre a resposta terapêutica e os efeitos colaterais. Um modelo matemático para descrever a dinâmica do vírus HIV e células CD4 é utilizado para calcular a dosagem ótima do medicamento no tratamento a curto prazo de pacientes com AIDS por um método de otimização direta utilizando uma função custo do tipo Bolza. Os parâmetros do modelo foram ajustados com dados reais obtidos da literatura. Com o objetivo de

  16. The Effectiveness of Life Skills Training on Enhancement of Self-Esteem and Marital Satisfaction among Addicts in Treatment Period

    R Nooripour

    2014-11-01

    Full Text Available Objective: This study has been done to determine the impact of life skills training on enhancement of self-esteem and marital satisfaction among addicts in treatment period. Method: The research design was semi experimental pretest-posttest with witness group. For each group 12men addicts in treatment period in Qazvin city were selected by available sampling. Rosenberg self-esteem and Enrich marital satisfaction questionnaires were administered among selected samples. Training workshop was conducted on role playing, questioning and answering which was taught by psychology professors in experimental group. Results: Results showed life skills training improved self-esteem and marital satisfaction of addicts in treatment period. Conclusion: Life skills training have a positive impact on self-esteem and marital satisfaction of individuals especially on addicts in treatment period, also life skills training in the field of smoking prevention enhances individuals’ skills (such as self-esteem, marital satisfaction, etc…. Life skills training empower person to actualize his knowledge, attitudes and values, and enable him to have motivation for healthy behavior which this will have significant impact on his relationship with his wife.

  17. State estimation and optimal long period clinical treatment of HIV seropositive patients

    Juliana M. Grégio

    2009-03-01

    Full Text Available Optimal control theory provides a very interesting quantitative method that can be used to assist the decision making process in several areas of application, such as engineering, biology, economics and sociology. The main idea is to determine the values of the manipulated variables, such as drug doses, so that some cost function is minimized, subject to physical constraints. In this work, the cost function reflects the number of CD4+T cells, viral particles and the drug doses. It is worth noticing that high drug doses are related to more intense side-effects, apart from the impact on the actual cost of the treatment. In a previous paper by the authors, the LQR - Linear Quadratic Regulator approach was proposed for the computation of long period maintenance doses for the drugs, which turns out to be of state feedback form. However, it is not practical to determine all the components of the state vector, due to the fact that infected and uninfected CD4+T cells are not microscopically distinguishable. In order to overcome this difficulty, this work proposes the use of Extended Kalman Filter to estimate the state, even though, because of the nonlinear nature of the involved state equations, the separation principle may not be valid. Extensive simulations were then carried out to investigate numerically if the control strategy consisting of the feedback of estimated states yielded satisfactory clinical results.A teoria de controle ótimo apresenta um método quantitativo muito interessante que pode ajudar no processo de tomada de decisão em algumas áreas de aplicação, tais como engenharia, biologia, economia e sociologia. A principal idéia é determinar os valores das variáveis controladas, tais como doses de medicamentos, onde alguma função-custo é minimizada, sujeito às restrições físicas. Neste trabalho, a função-custo reflete o número de células CD4+T, partículas virais e doses de medicamentos. É fato que altas dosagens de

  18. Orthosurgical treatment of patients in the growth period: at what cost?

    Jonas Capelli Junior

    2012-02-01

    Full Text Available Awaiting growth to end prior to starting orthosurgical treatment is sometimes extremely difficult for patients suffering from severe facial deformities. In cases of substantial skeletal disharmonies surgery may be indicated during active growth phase when the patient is psychosocially, aesthetically and/or functionally compromised. To indicate this therapy, orthodontic criteria, such as mild intramaxillary discrepancy and the possibility of preoperative preparation without major dental repositioning, must be met. A second orthosurgical treatment will probably prove necessary after growth has ended. This treatment should not be considered as routine, but rather as a therapeutic option in carefully selected cases.

  19. Influence of temperature of the short-period heat treatment on mechanical properties of the NiTi alloy

    Jaroslav Čapek

    2014-01-01

    Full Text Available The equiatomic alloy of nickel and titanium, known as nitinol, possesses unique properties such as superelasticity, pseudoplasticity, shape memory, while maintaining good corrosion resistance and sufficient biocompatibility. Therefore it is used for production of various devices including surgery implants. Heat treatment of nickel-rich NiTi alloys can result in precipitation of nickel-rich phases, which strongly influence tensile and fatigue behaviour of the material.In this work we have studied influence of short-period heat treatment on tensile behaviour and fatigue life of the NiTi (50.9 at. % Ni wire intended for fabrication of surgery stents.

  20. Undesirable financial effects of head and neck cancer radiotherapy during the initial treatment period

    Helen Egestad

    2015-01-01

    Full Text Available Background: Healthcare cost and reforms are at the forefront of international debates. One of the current discussion themes in oncology is whether and how patients’ life changes due to costs of cancer care. In Norway, the main part of the treatment costs is supported by general taxpayer revenues. Objectives: The objective of this study was to clarify whether head and neck cancer patients (n=67 in northern Norway experienced financial health-related quality of life (HRQOL deterioration due to costs associated with treatment. Design: HRQOL was examined by the European Organization for Research and Treatment of Cancer (EORTC QLQ-C30 in the beginning and in the end of radiation treatment in patients treated at the University Hospital in Northern Norway. Changes in financial HRQOL were calculated and compared by paired sample T-tests. Multiple regression analyses were used to examine correlations among gender, marital status, age and treatment with or without additional chemotherapy and changes in the HRQOL domain of financial difficulties. Results: The majority of score results at both time points were in the lower range (mean 15–25, indicating limited financial difficulties. We observed no statistically significant differences by gender, marital status and age. Increasing financial difficulties during treatment were reported by male patients and those younger than 65, that is, patients who were younger than retirement age. The largest effect was seen in singles. However, differences were not statistically significant. Conclusions: During the initial phase of the disease trajectory, no significant increase in financial difficulties was found. This is in line with the aims of the Norwegian public healthcare model. However, long-term longitudinal studies should be performed, especially with regard to the trends we observed in single, male and younger patients.

  1. Spectroscopic characterization of bone tissue of experimental animals after glucocorticoid treatment and recovery period

    Mitić, Žarko J.; Najman, Stevo J.; Cakić, Milorad D.; Ajduković, Zorica R.; Ignjatović, Nenad L.; Nikolić, Ružica S.; Nikolić, Goran M.; Stojanović, Sanja T.; Vukelić, Marija Đ.; Trajanović, Miroslav D.

    2014-09-01

    The influence of glucocorticoids on the composition and mineral/organic content of the mandible in tested animals after recovery and healing phase was investigated in this work. The results of FTIR analysis demonstrated that bone tissue composition was changed after glucocorticoid treatment. The increase of calcium, magnesium, phosphorus content and mineral part of bones was statistically significant in recovery phase and in treatment phase that included calcitonin and thymus extract. Some changes also happened in the organic part of the matrix, as indicated by intensity changes for already present IR bands and the appearance of new IR bands in the region 3500-1300 cm-1.

  2. A new treatment for some periodic Schr\\"{o}dinger operators II: the wavefunction

    He, Wei

    2016-01-01

    Following the approach of our previous paper we continue to study the asymptotic solution of periodic Schr\\"{o}dinger operators. Using the eigenvalues obtained earlier the corresponding asymptotic wavefunctions are derived. This gives further evidence in favor of the monodromy relations for the Floquet exponent proposed in the previous paper. In particular, the large energy asymptotic wavefunctions are related to the instanton partition function of N=2 supersymmetric gauge theory with surface operator. A relevant number theoretic dessert is appended.

  3. Open-Label, Long-Term Safety Study of Cevimeline in the Treatment of Postirradiation Xerostomia

    Purpose: To assess the safety of long-term cevimeline treatment of radiation-induced xerostomia in patients with head-and-neck cancer; and to assess the efficacy of cevimeline in these patients. Methods and Materials: A total of 255 adults with head-and-neck cancer who had received more than 40 Gy of radiation 4 months or more before entry and had clinically significant salivary gland dysfunction received cevimeline hydrochloride 45 mg t.i.d. orally for 52 weeks. Adverse events (AEs), their severity, and their relationship to the study medication were assessed by each investigator. The efficacy assessment was based on subjects' global evaluation of oral dryness on a scale of 0 (none) to 3 (severe). Results: Overall, 175 subjects (68.6%) experienced expected treatment-related AEs, most mild to moderate. The most frequent was increased sweating (47.5%), followed by dyspepsia (9.4%), nausea (8.2%), and diarrhea (6.3%). Fifteen subjects (5.9%) experienced Grade 3 treatment-related AEs, of which the most frequent was increased sweating. Eighteen subjects (7.1%) reported at least one serious AE, and 45 subjects (17.6%) discontinued study medication because of an AE. The global efficacy evaluation at the last study visit showed that cevimeline improved dry mouth in most subjects (59.2%). Significant improvement was seen at each study visit in the mean change from baseline of the numeric global evaluation score (p < 0.0001). Conclusions: Cevimeline 45 mg t.i.d. was generally well tolerated over a period of 52 weeks in subjects with xerostomia secondary to radiotherapy for cancer in the head-and-neck region

  4. Comparison of the efficacy of dexmedetomidine and esmolol in the treatment of increased hemodynamic response during the recovery period

    GÜNAY, Hülya; Moğol, Elif Başağan; Kaya, Fatma Nur; Türker, Gürkan; Yavaşcaoğlu, Belgin; Ahun, Filiz; Bebek, Ayşe Neslihan; Yeniaydoğmuş, Tuba

    2012-01-01

    Objectives: Our aim was to compare effectiveness of esmolol and dexmedetomidine in the treatment of increased hemodynamic response during anesthesia recovery period. Materials and methods: 60 ASA I-II patients whom scheduled for elective surgery with endotracheal intubation were randomized before extubation according to their hemodynamic parameters that were increased 20% of their baseline values in order to receive 1mg/kg esmolol (Group Esmolol, n= 30) or 0.5 µg/kg dexmedetomid...

  5. EFFECTS OF UV-C TREATMENT ON KIWIFRUIT QUALITY DURING THE STORAGE PERIOD

    Erdinc BAL

    2010-06-01

    Full Text Available This experiment was conducted at Namik Kemal University, Agriculture Faculty and Department of Horticulture in Turkey and Actinidia deliciosa cv. Hayward was used for this aim. In this study, Kiwifruits were irradiated with different doses of UV-C treatment (50, 75 and 100 cm distance for 5, 10 and 15 min. Later, they were put in polyethylene container with packed polyethylene bags and stored under the conditions of cool air store (at 0-10C, 90-95 % relative humidity for 200 days. During the experiment, quality attributes of kiwifruit was assessed at 40 days intervals and UV-C treatment from 75 cm distance for 10 min was especially found to be more effective than the others.

  6. Our experiences in surgical treatment of thoracic echinococcosis during the period 1977-1986.

    Gashi, M; Beqiri, S B; Guguli, M; Recica, X; Ahmedi, E

    1988-01-01

    Our experience is based on 147 patients with thoracic echinococcosis (TE) who underwent surgery. Of these, 131 (89.1%) patients had pulmonary TE, 3 (2.1%) had extra-pulmonary TE, and 13 (8.8%) had pulmohepatic TE Ninety-nine (67.3%) patients had uncomplicated TE, and 48 (32.7%) had complicated TE. All patients underwent surgery. In 129 (87.8%) patients, we performed cystectomy with capitonage and in 18 (12.2%) cases we performed a lung resection (lobectomy or segmentectomy). Postoperative complications occurred in 2 (1.4%) patients, and recurrence in 2 (1.4%) patients who previously had complicated TE. On admission, there was no evidence of allergic reactions in patients with complicated TE. The average time of postoperative treatment was 13 days. The results of surgical treatment were excellent. The conclusion reached is that a cystectomy with capitonage is the treatment of choice for pulmonary echinococcosis, while lung resection may be necessary if lung tissue has been destroyed by prolonged compression or infection. PMID:3272249

  7. Comparison of clinical features in surgical treatment of lung cancer over two 10-year periods in Shinshu University Hospital

    Lung cancer is one of the most common fatal cancers. We retrospectively evaluated 949 resected cases of lung cancer from January 1985 to December 2004 by comparative analysis of the first (1985-1994) and second 10-year period (1995-2004) with reference to patient age, gender, chief complaint, histological type, tumor differentiation, tumor size, operative method, pathological stage, and survival rate. Surgical treatment for patients older than 75 years of age doubled in the second 10-year period. CT health screenings indicating lung cancer increased. The percentage of well-differentiated adenocarcinoma increased in both males and females. Cases of tumors less than 20 mm, especially those less than 10 mm, increased in the second 10-year period. The ratio of pneumonectomy decreased, and limited resection including partial resection and segmentectomy increased. The number of cases in pathological stage IA increased. The 5-year survival rates in stages IA, IIIA, IV, and overall in the second period were statistically higher than in the first period. An age of 70 years of more, being male, first medical contact other than CT health screening, carotid endarterectomy (CEA) elevation, histological type other than well-differentiated adenocarcinoma, tumor size, lymph node metastasis, and pneumonectomy were all considered factors impacting survival in resected cases of lung cancer. (author)

  8. Dark Period Following UV-C Treatment Enhances Killing of Botrytis cinerea Conidia and Controls Gray Mold of Strawberries.

    Janisiewicz, Wojciech J; Takeda, Fumiomi; Glenn, D Michael; Camp, Mary J; Jurick, Wayne M

    2016-04-01

    Strawberries are available throughout the year either from production in the field or from high and low tunnel culture. Diversity of production conditions results in new challenges in controlling diseases before and after harvest. Fungicides have traditionally been used to control these diseases; however, their limitations necessitate a search for new approaches. We found that UV-C irradiation of Botrytis cinerea, a major pathogen of strawberry, can effectively kill this fungus if a dark period follows the treatment. The inclusion of a 4-h dark period resulted in almost complete kill of B. cinerea conidia on agar media at a dose of 12.36 J/m2. The UV-C dose did not cause a reduction in photosynthesis in strawberry leaves or discoloration of sepals, even after exposing plants repeatedly (twice a week) for 7 weeks. Although irradiation of dry conidia of B. cinerea with this dose resulted in some survival, the conidia were not infective and not able to cause decay even when inoculated onto a highly susceptible mature apple fruit. Irradiation of strawberry pollen at 12.36 J/m2 did not affect pollen germination, tube growth and length in vitro, or germination and tube growth in the style of hand-pollinated emasculated strawberry flowers. No negative effect of the UV-C treatment was observed on fruit yield and quality in high tunnel culture. In the fruit and flower petal inoculation tests, the UV-C treatment was highly effective in reducing fruit decay and petal infection. This UV-C treatment with an exposure time of 60 s may be useful in controlling gray mold in tunnel production of strawberries and may also have the potential for use in intensive field and indoor production of other fruits and vegetables providing that a 4-h dark period follows the irradiation. PMID:26714103

  9. [Asthenic syndrome in clinical course of acute period of brain concussion during complex treatment using nootropic agents].

    Tkachov, A V

    2008-01-01

    The comparative analysis of a complex examination of 108 persons aged from 16 till 60 years in acute period of closed craniocerebral injury (CCCT) has been done. Every participants have been divided into 2 groups depending on a nootrop medication they receive in a complex treatment. A control group consisted of 30 practically healthy people. Objective examination by means of tests was done on the 1-st, 10-th that 30-th day of treatment. Patients of 1-st (37 persons) group received piracetam in complex treatment and patients of the 2-nd group (71 persons) pramistar. Patients of the first group received a base treatment (analgetics, tranquilizers, vitamins of group B, magnesium sulfate, diuretic preparations) as well as piracetam at dosage 0.2, two tablets three times per day. The Patients of the 2-nd group received a base treatment as well as pramistar at dosage 0.6, one tablet 2 times per day. Specially developed multiaspects scales and questionnaires, MRT of the brain and EEG have been used for objectification of patient, complaints. During a complex clinico-neuropsychological examination it was found that all cases of concussion of the brain are accompanied by those or other asthenic disorders. PMID:19145827

  10. Treatment for retinopathy of prematurity in Denmark in a ten-year period (1996-2005): Is the incidence increasing?

    Slidsborg, C.; Olesen, H.B.; Jensen, Peter Koch;

    2008-01-01

    OBJECTIVE. The objective of this study was to analyze the population incidence of retinopathy of prematurity treatment in Denmark in the 10-year period from 1996 to 2005. METHODS. Patient charts of infants treated for retinopathy of prematurity and the national birth registry provide information...... about neonatal parameters. These parameters, along with birth in the latter half of the period (2001-2005), were analyzed as risk factors for retinopathy of prematurity. The national registry for blind and visually impaired children was accessed to obtain information about visual impairment attributable...... to retinopathy of prematurity in both treated and untreated infants. RESULTS. The study population consisted of 5467 Danish preterm infants born in 1996 to 2005, with a gestational age of <32 weeks, who survived for >= 5 postnatal weeks; 2616 were born in 1996 to 2000, and 2851 were born in 2001 to...

  11. Performance of wetland systems in the treatment of sewage generated at an educational institution, after a recession period

    Paulo Fortes Neto

    2011-12-01

    Full Text Available Education institutions are potential generators of large volumes of domestic sewage. Studies of natural systems for effluent treatment have shown good efficiency and low cost compared to traditional systems. This makes them suitable for various segments of society, including educational institutions. A characteristic shared by most educational institutions is that they have the same academic calendars that include a long period of recess when, in many cases, the flow of sewage systems drops to almost zero, causing damage to both macrophytes in sewage bed and their associated microorganisms. This study aimed to evaluate the efficiency of a wetland system in an educational institution, after the recess period. It was observed for 45 days if there were signs of natural recovery, without any intervention. After this period, 15 seedlings of Thypha sp. were planted in the sewage bed, and analyses were performed for 45 additional days. The system efficiency in reducing turbidity, NH3, NO3- and phosphorus was, respectively, 63.0%, 21.7%, 31.1% and 20.3%, and for BOD, COD and thermotolerant coliforms, the average efficiency was 46.0%, 29.7% and 44.0%, respectively. If considered only the period after planting the results improved, with the following results: turbidity = 78.2%, 38.0% = NH3, NO3- = 53.2% = 25.6% phosphorus, BOD = 66, 2% = 36.5% COD and thermotolerant coliform = 60.7%. The results demonstrated the importance of vegetation bed for the efficiency of such treatment system.

  12. Fall in incidence of guinea-worm infection in western Nigeria after periodic treatment of infected persons

    Kale, O. O.

    1982-01-01

    Between 1971 and 1974 a series of drug trials was conducted in 17 rural communities in western Nigeria where guinea-worm is endemic. During these trials and in subsequent years treatment, in the form of chemotherapy and/or dressing of ulcers, was given to all infected persons. A longitudinal study of infection in these villages showed a marked fall in the annual incidence over an 8-year period. The aggregate reduction in incidence in the three sectors surveyed was from 15.5% to 0.5% in sector...

  13. [Complex pathogenetic treatment schemes of vascular dyscirculatory disorders in the remote period after exposure to low dose radiation].

    2013-01-01

    Complex studies including modern methods of investigation of structures and functions of nervous system: electroencephalograsphy (EEG), coherent analysis, neuropsychological study and methods of neuroimaging were performed in 517 participants in liquidation of consequences of the accident (LCA) at the Chernobyl NPP in 1986-1987. Dyscirculatory metabolic encephalopathy was revealed to be the main pathology with the etiological mechanism based on dyscirculatorhypoxic and metabolic disorders. Complexity of the revealed symptoms testified to an early organism aging in remote periods after exposure to low dose radiation. Pathogenetic schemes were developed for treatment of dyscirculatory encephalopathy in liquidators, which include drugs improving blood supply, antiaggregants, antioxidants and metabolites of the brains in various combinations. Taking into consideration that early appearance of vascular dyscirculatory disorders observed in liquidators is the sign of early aging of the organism, geroprotectors were added to treatment schemes. PMID:25507773

  14. Impact of periodic health examination on surgical treatment for uterine fibroids in Beijing: a case-control study

    Yang Ling-Ling

    2010-12-01

    Full Text Available Abstract Background During the past 2 decades, there has been a rapid proliferation of "health examination center (HEC" across China. The effects of their services on public's health have not been systemically investigated. This study aimed to assess the impact of periodic health examination (PHE at HEC on surgical treatment for uterine fibroids in Beijing residents. Methods We identified 224 patients with a primary diagnosis of uterine fibroids who had surgical treatment at four Level-1 general hospitals in Beijing, from June 1, 2009 to October 20, 2009. Controls were women who did not have surgery for uterine fibroids, matched (1:1 ratio for age (within 2 years. A standard questionnaire was used to inquire about whether participants had PHE at HEC during the previous 2 years. Results PHE at HEC within 2 years were associated with surgical treatment for uterine fibroids. Odds ratios was 4.05 (95% CI, 2.61-6.29 P Conclusions Our study showed PHE currently provided at HEC in China were associated with significantly increased use of surgical treatment for uterine fibroids in women. Further studies are needed to assess the effects of PHE on clinical as well as on broad societal outcomes in Chinese in contemporary medical settings.

  15. Apomorphine Penject – Emerging Evidence and Treatment Strategies for Delayed on and off Periods in Parkinson’s disease

    Olivier Rascol

    2014-07-01

    Full Text Available This educational symposium was held during the Joint Congress of European Neurology (EFNS–ENS, which took place from 31st May to 3rd June 2014 in Istanbul, Turkey, and was sponsored by Britannia Pharmaceuticals Limited. The symposium debated the problem of delayed ON and OFF periods in Parkinson’s disease that can occur even in patients optimised on oral medication. Emerging evidence for the rapid and effective resolution of such complications using apomorphine intermittent injection (penject was reviewed with particular reference to the positive results of the recent AM IMPAKT trial in patients with morning akinaesia. The discussions were illustrated with examples of ‘real life’ patient case studies to help determine which patients might be best suited for treatment with apomorphine injection.

  16. The treatment of restless legs syndrome and periodic limb movement disorder. An American Academy of Sleep Medicine Review.

    Hening, W; Allen, R; Earley, C; Kushida, C; Picchietti, D; Silber, M

    1999-11-01

    A task force consisting of six authors reviewed the published literature on the therapy of the restless legs syndrome or periodic limb movements in sleep available in indices through April, 1998. They selected the 45 articles for detailed review which presented original investigations of therapeutic impact on the restless legs syndrome (RLS) or periodic limb movements (PLM) and which met minimal standards. These articles dealt with a range of pharmacological and other treatment modalities, although most dealt with medications and almost half of those concentrated on dopaminergic agents, especially levodopa in various formulations. Almost half of the articles reviewed used controlled methodologies, most commonly cross-over methodologies with randomized allocation of subjects. Multi-center studies with large numbers of subjects and long-term controlled studies were not found. Information was extracted from the articles and study design, clinical definition, evaluative measures, side effects, and outcomes were tabulated in 6 evidence tables and summarized in the accompanying text. This literature was evaluated for the nature of the studies performed and its coverage of potential therapies. The review concludes with comments on possible future directions for therapeutic investigation based on the current state of the literature. PMID:10566916

  17. Comparison of the efficacy of dexmedetomidine and esmolol in the treatment of increased hemodynamic response during the recovery period

    Ayşe Neslihan Bebek

    2012-03-01

    Full Text Available Objectives: Our aim was to compare effectiveness of esmololand dexmedetomidine in the treatment of increasedhemodynamic response during anesthesia recovery period.Materials and methods: 60 ASA I-II patients whomscheduled for elective surgery with endotracheal intubationwere randomized before extubation according to theirhemodynamic parameters that were increased 20% oftheir baseline values in order to receive 1mg/kg esmolol(Group Esmolol, n= 30 or 0.5 μg/kg dexmedetomidine(Group Dexmedetomidine, n= 30. Heart rate (HR, systolicand diastolic blood pressures (SBP,DBP, peripheral oxygensaturation (SpO2, end tidal carbon dioxide (ETCO2values, extubation time, recovery time were recorded. Theduration till having pain requiring analgesic was recordedand cognitive functions were evaluated with short memoryorientation concentration test at 20th and 50th minutes.Results: After drug, HR reductions were significant at allperiods in group Dexmedetomidine (Z2-Z10: p<0.001,Z11:p=0.001, Z12, p=0.006. In group DexmedetomidineSBP value was high at 3rd min after drug (p<0.001, andSBP values were lower in all periods before and after extubation(Z6- Z10: p<0.001, Z11: p=0.02, Z12: p=0.04.In group Dexmedetomidine DBP value was higher at 1stmin after drug (p=0.001, DBP values were lower at 10thmin after drug and before extubation (p= 0.045, p=0.001.The duration of pain requiring analgesic and recoveryperiod were longer in dexmedetomidine group (p<0.001,p<0.001.Conclusions: Although esmolol and dexmedetotimidineattenuated hemodynamic response during recovery period,dexmedetotimidine was more effective in hemodynamicstabilization and the duration of pain requiring analgesicwas longer. Esmolol provided faster recovery time. JClin Exp Invest 2012; 3(1: 53-60

  18. Planetary populations in the mass-period diagram: A statistical treatment of exoplanet formation and the role of planet traps

    The rapid growth of observed exoplanets has revealed the existence of several distinct planetary populations in the mass-period diagram. Two of the most surprising are (1) the concentration of gas giants around 1 AU and (2) the accumulation of a large number of low-mass planets with tight orbits, also known as super-Earths and hot Neptunes. We have recently shown that protoplanetary disks have multiple planet traps that are characterized by orbital radii in the disks and halt rapid type I planetary migration. By coupling planet traps with the standard core accretion scenario, we showed that one can account for the positions of planets in the mass-period diagram. In this paper, we demonstrate quantitatively that most gas giants formed at planet traps tend to end up around 1 AU, with most of these being contributed by dead zones and ice lines. We also show that a large fraction of super-Earths and hot Neptunes are formed as 'failed' cores of gas giants—this population being constituted by comparable contributions from dead zone and heat transition traps. Our results are based on the evolution of forming planets in an ensemble of disks where we vary only the lifetimes of disks and their mass accretion rates onto the host star. We show that a statistical treatment of the evolution of a large population of planetary cores caught in planet traps accounts for the existence of three distinct exoplanetary populations—the hot Jupiters, the more massive planets around r = 1 AU, and the short-period super-Earths and hot Neptunes. There are very few populations that feed into the large orbital radii characteristic of the imaged Jovian planet, which agrees with recent surveys. Finally, we find that low-mass planets in tight orbits become the dominant planetary population for low-mass stars (M * ≤ 0.7 M ☉).

  19. Planetary populations in the mass-period diagram: A statistical treatment of exoplanet formation and the role of planet traps

    Hasegawa, Yasuhiro [Currently EACOA Fellow at Institute of Astronomy and Astrophysics, Academia Sinica (ASIAA), Taipei 10641, Taiwan. (China); Pudritz, Ralph E., E-mail: yasu@asiaa.sinica.edu.tw, E-mail: pudritz@physics.mcmaster.ca [Also at Origins Institute, McMaster University, Hamilton, ON L8S 4M1, Canada. (Canada)

    2013-11-20

    The rapid growth of observed exoplanets has revealed the existence of several distinct planetary populations in the mass-period diagram. Two of the most surprising are (1) the concentration of gas giants around 1 AU and (2) the accumulation of a large number of low-mass planets with tight orbits, also known as super-Earths and hot Neptunes. We have recently shown that protoplanetary disks have multiple planet traps that are characterized by orbital radii in the disks and halt rapid type I planetary migration. By coupling planet traps with the standard core accretion scenario, we showed that one can account for the positions of planets in the mass-period diagram. In this paper, we demonstrate quantitatively that most gas giants formed at planet traps tend to end up around 1 AU, with most of these being contributed by dead zones and ice lines. We also show that a large fraction of super-Earths and hot Neptunes are formed as 'failed' cores of gas giants—this population being constituted by comparable contributions from dead zone and heat transition traps. Our results are based on the evolution of forming planets in an ensemble of disks where we vary only the lifetimes of disks and their mass accretion rates onto the host star. We show that a statistical treatment of the evolution of a large population of planetary cores caught in planet traps accounts for the existence of three distinct exoplanetary populations—the hot Jupiters, the more massive planets around r = 1 AU, and the short-period super-Earths and hot Neptunes. There are very few populations that feed into the large orbital radii characteristic of the imaged Jovian planet, which agrees with recent surveys. Finally, we find that low-mass planets in tight orbits become the dominant planetary population for low-mass stars (M {sub *} ≤ 0.7 M {sub ☉}).

  20. CRYOGENIC TREATMENT FOR CANCER OF THE TONGUE AND ORAL CAVITY (ANALYSIS OF ITS EFFICIENCY ACCORDING TO SURVIVAL RATES IN THE PERIOD 1975–2009)

    T. D. Tabolinovskaya

    2013-01-01

    Case histories of 366 patients with cancer of the oral mucosa, tongue, and oropharynx who had received cryogenic treatment at the N.N. Blokhin Russian Cancer Research Center in the period 1975 to 2009 served as the material for the investigation. Analysis of the longterm results of cryogenic treatment for primary and recurrent cancers and tumors untreated after traditional treatments showed the efficiency of this method in 75.8 and 48.2 % of primary and recurrent cancer patients, respectively...

  1. Secular, Spiritual and religious Existential concerns during final diagnostics and treatment period – The lived experiences of women undergoing ovarian cancer surgery

    Hounsgaard, Lise; Seibæk, L.; Hvidt, N. C.

    2013-01-01

    a woman with ovarian cancer during her first treatment period. Although the women experienced their health to be seriously threatened, they also felt hope, will, and courage. The diagnostic procedures and treatment had comprehensive impact on their lives. However, hope and spirituality were important......Introduction. This paper deals with secular, spiritual, and religious existential concerns during severe illness. Materials and Methods. Qualitative research interviews were made before and after surgery with women who underwent final diagnostics, surgery, and chemotherapy for ovarian cancer...

  2. Changes in fecal microbiota and metabolomics in a child with juvenile idiopathic arthritis (JIA) responding to two treatment periods with exclusive enteral nutrition (EEN).

    Berntson, Lillemor; Agback, Peter; Dicksved, Johan

    2016-06-01

    The microbiome and immune system of the digestive tract are highly important in both health and disease. Exclusive enteral nutrition (EEN) is a common anti-inflammatory treatment in children with Crohn's disease in the European countries, and the mechanism is most likely linked to changes in the intestinal microbiome. In the present study, EEN was given in two treatment periods several months apart to a patient with very severe, disabling juvenile idiopathic arthritis (JIA), with a remarkable clinical response as the result. The aim of the present study was to study how the EEN treatment influenced the microbiome and metabolome of this patient. Fecal samples from before, during, and between treatments with EEN were studied. The microbiome was analyzed by sequencing of 16S rRNA amplicons using Illumina MiSeq, and the metabolome was analyzed using nuclear magnetic resonance. The microbiome changed markedly from treatment with EEN, with a strong reduction of the Bacteroidetes phylum. Metabolic profiles showed clear differences before, during, and between treatment with EEN, where butyrate, propionate, and acetate followed a cyclic pattern with the lowest levels at the end of each treatment period. This patient with JIA showed remarkable clinical improvement after EEN treatment, and we found corresponding changes in both the fecal microbiome and the metabolome. Further studies are needed to explore the pathophysiological role of the intestinal canal in children with JIA. PMID:27021336

  3. HEART RATE VARIABILITY IN PATIENTS WITH PREVIOUS Q-WAVE MYOCARDIAL INFARCTION IN DIFFERENT TREATMENT SCHEMES IN EARLY POSTINFARCTION PERIOD

    A. A. Abdullaev

    2016-01-01

    Full Text Available Aim. To evaluate influence of various drug combinations on heart rate variability (HRV in patients with previous Q-wave myocardial infarction (Q-MI in outpatient period of rehabilitation.Material and methods. A total of 316 patients with previous Q-MI were randomized into three groups. Patients of the control group (n=103 received standard therapy (acetylsalicylic acid, enalapril, metoprolol, simvastatin during 2 years after discharge from the hospital. Patients of the first studied group (n=107 were additionally treated with trimetazidine, and patients of the second group (n=106 received combined therapy with ramipril, carvedilol and trimetazidine. HRV parameters (derived from ECG 5-minute recording were registered at the beginning of the study, 6 and 24 months after the beginning of the study.Results. HRV parameters improvement was more significant in the second group compared to the first and to control groups. In the second group LF increased from 223.8±56.2 to 734±90.9 мs2 (p<0.001, in the first group – from 217.8±54.3 to 713±88.1 мs2, and in control group – from 225.4±49.0 to 589±72.0 мs2. HF increase was also more significant in the second group: from 189.5±54.4 to 801±97.5 мs2 (p<0.001 compared to the first and to control groups: from 176.6±47.3 to 579±91.2 мs2 and from 180.9±50.4 to 487±83.4 мs2, respectively. SDNN rose from 27.8±3.2 to 52.4±4.4 ms (p<0.05 in the second group, from 27.4±2.7 to 41.2±3.8 ms in control group, and from 26.7±3.0 to 46.5±4.0 ms in the first group. RRNN increased from 664.5±99.0 to 833±98.7 ms (p<0.05 in the second group, from 676.2±85.3 to 793±87.6 ms in control group, and from 658.1±97.2 to 826±92.8 ms in the first group.Conclusion. Two-year treatment with enalapril and metoprolol as a part of standard therapy improves HRV parameters of Q-MI patients. Addition of trimetazidine to this combination leads to even more significant improvement of HRV parameters in postinfarction

  4. Rationale and study design of a three-period, 58-week trial of ferric citrate as a phosphate binder in patients with ESRD on dialysis.

    Umanath, Kausik; Sika, Mohammed; Niecestro, Robert; Connelly, Carolyn; Schulman, Gerald; Koury, Mark J; Lewis, Julia B; Dwyer, Jamie P

    2013-01-01

    Chronic kidney disease associated mineral and bone disorders arise as a result of aberrant bone mineral metabolism in patients with advancing levels of renal dysfunction and end-stage renal disease. One of the cornerstones of treatment is the use of phosphate-binding agents. We describe the rationale and study design for a clinical trial to assess the safety and efficacy of ferric citrate as a phosphate binder. This trial is a three-period, international, multicenter, randomized, controlled clinical trial to assess the safety and efficacy of ferric citrate as a phosphate binder, consisting of a 2-week washout period, a 52-week safety assessment period in which subjects are randomized to ferric citrate or active control, and a 4-week efficacy assessment period in which subjects randomized to ferric citrate in the safety assessment period are randomized to ferric citrate or placebo. Eligible subjects include end-stage renal disease patients who have been treated with thrice-weekly hemodialysis or peritoneal dialysis for at least 3 months in dialysis clinics in the United States and Israel. Primary outcome measure will be the effect of ferric citrate vs. placebo on the change in serum phosphorus. Safety assessments will be performed by monitoring adverse events, concomitant medication use, and sequential blood chemistries (including iron parameters, phosphorus, and calcium). This three-period trial will assess the efficacy of ferric citrate as a phosphate binder. If proven safe and efficacious, ferric citrate will likely provide an additional phosphate binder to treat chronic kidney disease associated mineral and bone disorders. PMID:22702490

  5. Surgical treatment of partial atrioventricular septal defect: functional analysis of the mitral valve in the postoperative period

    Josué Viana Castro Neto

    2002-11-01

    Full Text Available OBJECTIVE: To study mitral valve function in the postoperative period after correction of the partial form of atrioventricular septal defect. METHODS: Fifty patients underwent surgical correction of the partial form of atrioventricular septal defect. Their mean age was 11.8 years and 62% of the patients were males. Preoperative echocardiography showed moderate and severe mitral insufficiency in 44% of the patients. The mitral valve cleft was sutured in 45 (90% patients (group II - GII. Echocardiographies were performed in the early postoperative period, and 6 and 12 months after hospital discharge. RESULTS: The patients who had some type of arrhythmia in the postoperative period had ostium primum atrial septal defect of a larger size (2.74 x 2.08 cm. All 5 patients in group I (GI, who did not undergo closure of the cleft, had a competent mitral valve or mild mitral insufficiency in the preoperative period. One of these patients began to have moderate mitral insufficiency in the postoperative period. On the other hand, in GII, 88.8% and 82.2% of the patients had competent mitral valve or mild mitral insufficiency in the early and late postoperative periods, respectively. CONCLUSION: The mitral valve cleft was repaired in 90% of cases. Echocardiography revealed competent mitral valve or mild mitral insufficiency in 88.8% and 82.2% of GII patients in the early and late postoperative periods, respectively.

  6. 经行风疹的中药周期性治疗%Periodical treatment of Chinese herbs for menstrual rubella

    李凌

    2012-01-01

    The mechanism of menstrual rubella formed to be different shapes, characterized by itchy welts and attacked patient recurrently, they frequently came before menstruation and through the menstrual period. The mechanism of menstrual rubella in Chinese theory is heat accumulated in Yangming meridian and fur offended by wind-heat. The treatment for menstrual rubella is periodical treatment according to menstrual cycle. The basic principal is abreacting wind, nourishing Wood and eliminating heat in the premenstrual period, driving wind and removing heat in the menstrual period, nourishing blood and calming wind after menstruation. After the treatment, the chronic urticaria was cured and never attacked the patients before or during menstruation days any more.%经行风疹块,每值临经或行经期间,全身皮肤突起疹块,疹形大小不一,瘙痒异常,甚则融合成片,经净渐退,常反复发作,迁延不愈.若经行风疹为阳明积热于内,风热外侵皮毛;治疗可按月经周期性治疗,经前疏风养血,清热除湿;经期祛风清热;经后主要予以养血熄风治疗为基本治疗原则.

  7. High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period

    W. Louis Cleveland

    2009-01-01

    Full Text Available This paper describes an individual who was diagnosed with obsessive-compulsive disorder (OCD and body dysmorphic disorder (BDD at age 17 when education was discontinued. By age 19, he was housebound without social contacts except for parents. Adequate trials of three selective serotonin reuptake inhibitors, two with atypical neuroleptics, were ineffective. Major exacerbations following ear infections involving Group A -hemolytic streptococcus at ages 19 and 20 led to intravenous immune globulin therapy, which was also ineffective. At age 22, another severe exacerbation followed antibiotic treatment for H. pylori. This led to a hypothesis that postulates deficient signal transduction by the N-methyl-D-aspartate receptor (NMDAR. Treatment with glycine, an NMDAR coagonist, over 5 years led to robust reduction of OCD/BDD signs and symptoms except for partial relapses during treatment cessation. Education and social life were resumed and evidence suggests improved cognition. Our findings motivate further study of glycine treatment of OCD and BDD.

  8. Effect of rehabilitation treatment during different period on recovery of patients with spinal cord injury%脊髓损伤患者不同时期介入康复治疗的效果观察

    马春山; 秦四遥

    2001-01-01

    Objective To investigate efficacy of rehabilitation treatment for patients with spinal cord injury(SCI) during different period.Methods 108 patients received rehabiltiation treatment during different period after SCI.Comparision study was performed retrospectively.Results ADL of patients recepting rehabilitation treatment 3 months after SCI was increased significantly.Conclusion Early rehabilitation interventions significantly accelerate functional recovery of patients with SCI.

  9. Beneficial effects of a neurotrophic peptidergic mixture persist for a prolonged period following treatment interruption in a transgenic model of Alzheimer's disease.

    Rockenstein, Edward; Ubhi, Kiren; Pham, Emiley; Michael, Sarah; Doppler, Edith; Novak, Philipp; Inglis, Chandra; Mante, Michael; Adame, Anthony; Alvarez, X Anton; Moessler, Herbert; Masliah, Eliezer

    2011-11-01

    Neurodegenerative disorders such as Alzheimer's disease (AD) are characterized by the loss of neurotrophic factors, and experimental therapeutical approaches to AD have investigated the efficacy of replacing or augmenting neurotrophic factor activity. Cerebrolysin, a peptide mixture with neurotrophic-like effects, has been shown to improve cognition in patients with AD and to reduce synaptic and behavioral deficits in transgenic (tg) mice overexpressing the amyloid precursor protein (APP). However, it is unclear how long-lasting the beneficial effects of Cerebrolysin are and whether or not behavioral and neuropathological alterations will reappear following treatment interruption. The objective of the present study was to investigate the consequences of interrupting Cerebrolysin treatment (washout effect) 3 and 6 months after the completion of a 3-month treatment period in APP tg mice. We demonstrate that, in APP tg mice, Cerebrolysin-induced amelioration of memory deficits in the water maze and reduction of neurodegenerative pathology persist for 3 months after treatment interruption; however, these effects dissipate 6 months following treatment termination. Immunohistochemical analysis demonstrated that the decrease in neocortical and hippocampal amyloid plaque load observed in Cerebrolysin-treated APP tg mice immediately after treatment was no longer apparent at 3 months after treatment interruption, indicating that the beneficial effects of Cerebrolysin at this time point were independent of its effect on amyloid-β deposition. In conclusion, the results demonstrate that the effects of Cerebrolysin persist for a significant period of time following treatment termination and suggest that this prolonged effect may involve the neurotrophic factor-like activity of Cerebrolysin. PMID:21793038

  10. Reduced gastric acid production in burn shock period and its significance in the prevention and treatment of acute gastric mucosal lesions.

    Zhu, Li; Yang, Zhong-Cheng; Li, Ao; Cheng, De-Chang

    2000-02-01

    AIM:To investigate the changes of gastric acid production and its mechanism in shock period of severe burn in rats.METHODS:A rat model with 30% TBSA full thickness burn injury was employed and the gastric acid production,together with gastric mucosal blood flow (GMBF) and energy charge (EC) were measured serially within 48h postburn.RESULTS:The gastric acid production in the acute shock period was markedly inhibited after severe burn injury.At the 3rd h postburn,the gastric juice volume, total acidity and acid output were already significantly decreased (P anti-acid drugs during burn shock period was unreasonable in some respects. Therefore, taking effective measures to improve gastric mucosal blood perfusion as early as possible postburn might be more preferable for the AGML prevention and treatment. PMID:11819529

  11. 围生期出血的治疗和护理%Treatment and care of hemorrhage in the prenatal period

    逯朝霞; 刘宽荣

    2014-01-01

    目的:探讨围生期出血的治疗和护理方法。方法回顾性分析2009年1月-2011年12月我院38例围生期出血患者的临床资料、治疗结果和护理方法。结果38例患者中急症子宫切除术3例,清宫术26例,剖宫产4例,助产分娩5例,6例输注血液制品。均痊愈出院。结论对孕产妇进行围生期全程心理干预和护理,能减少围生期出血的危险。%ObjectiveConclusion the treatment of hemorrhage in the perinatal period and nursing methods. MethodsOn between January 2009 and December 2009,the clinical data of 38 cases of hemorrhage in the perinatal period,the treatment and nursing methods were analyzed.ResultsEmergency hysterectomy 3 cases,26 cases of cesarean section 4 cases,the birth of midwifery in 5 cases. Infusion of 6 cases of blood products. Hospital were recovered.ConclusionTo the entire psychological intervention in the perinatal period and maternal care,can reduce the risk of hemorrhage in the perinatal period.

  12. Comparative evaluation of course and treatment of climacteric period in women living in radionuclide-contaminated territories

    The appearance of heavy forms of climacteric syndrome in territories with density of radioactive contamination up to 15 Ci/km2 is higher than in those living in territories with the level of contamination from 1 to 5 Ci/km2. At treatment of climacteric syndrome during menopause in women living in radionuclide-contaminated territory, preparations containing natural estrogen and gestagens are of higher priority. (Authors)

  13. Homeopathic treatment of elderly patients - a prospective observational study with follow-up over a two year period

    Willich Stefan N

    2010-02-01

    Full Text Available Abstract Background Very little is known about the range of diagnoses, course of treatment and long-term outcome in elderly patients who choose to receive homeopathic medical treatment. We investigated homeopathic practice in an industrialised country under everyday conditions. The aim of the study was to determine the spectrum of diagnoses and treatments, as well as to describe the course of illness over time among older patients who chose to receive homeopathic treatment. Methods In this subgroup analysis of a prospective, multicentre cohort study totally including 3981 patients treated by homeopathic physicians in primary care practices in Germany and Switzerland, data was analysed from all patients > 70 years consulting the physician for the first time. The main outcome measures were: assessment by patient of the severity of complaints (numeric rating scales and quality of life (SF-36 and by the physician of the severity of diagnoses (numeric rating scales at baseline, and after 3, 12, and 24 months. Results A total of 83 patients were included in the subgroup analysis (41% men, mean age 73.2 ± (SD 3.1 years; 59% women, 74.3 ± 3.8 years. 98.6 percent of all diagnoses were chronic with an average duration of 11.5 ± 11.5 years. 82 percent of the patients were taking medication at baseline. The most frequent diagnoses were hypertension (20.5%, 11.1 ± 7.5 years and sleep disturbances (15.7%, 22.1 ± 25.8 years. The severity of complaints decreased significantly between baseline and 24 months in both patients (from 6.3 (95%CI: 5.7-6.8 to 4.6 (4.0-5.1, p Conclusion The severity of disease showed marked and sustained improvements under homeopathic treatment, but this did not lead to an improvement of quality of life. Our findings might indicate that homeopathic medical therapy may play a beneficial role in the long-term care of older adults with chronic diseases and studies on comparative effectiveness are needed to evaluate this hypothesis.

  14. Time trends of cannabis use among treatment-seeking individuals at government de-addiction centers across India over a period of 7 years

    Yatan Pal Singh Balhara

    2016-01-01

    Full Text Available Background: Cannabis continues to be the most commonly used illicit psychoactive substance globally. The National Survey in India conducted in the year 2004 also reported it to be the most commonly used illicit substance in the country. Furthermore, it was reported to be the second most commonly used psychoactive substance by the treatment seekers at de-addiction centers in the country. Objectives: To assess time trends of cannabis use among treatment-seeking individuals at government de-addiction centers across India over a period of 7 years. Materials and Methods: The study utilized data collected through Drug Abuse Monitoring System across India. The data of treatment seekers from de-addiction centers established under the Drug De-addiction Program, Ministry of Health and Family Welfare, Government of India and supported by the Ministry of Social Justice and Empowerment, Government of India (122 in number across the country were analyzed. Results: A total of 107,469 individuals sought treatment from government de-addiction centers over the 7 years (2007–2013 period. With the exception of an aberration for the year 2012, there has been a steady decline in the proportion of treatment seekers who are not current cannabis users. A significantly greater proportion (Chi-square: 586.30, df: 1, P < 0.001 of individuals with current cannabis use alone or along with tobacco (20.4% tend to have a co-morbid psychiatric disorder as compared to treatment seekers with current use of substances other than cannabis (6.1%. Conclusions: It is important to focus on cannabis in clinical service delivery and research in the country.

  15. Consistent treatment of charged systems within periodic boundary conditions: The Projector Augmented-Wave and pseudopotential methods revisited

    Crocombette, Jean-Paul; Bruneval, Fabien; Gonze, Xavier; Dorado, Boris; Torrent, Marc; Jollet, Francois

    2014-03-01

    The ab initio calculation of charged defect properties in solids is not straightforward because of the delicate interplay between the long-range Coulomb interaction and the periodic boundary conditions. We derive the Projector Augmented-Wave (PAW) energy and hamiltonian with a special care on the potentials from Coulomb interaction. By explicitly treating the background compensation charge, we find a new term in the total energy of charged cells and in the potential. We show that this background term is needed to accurately reproduce all-electron calculations of the formation energy of a charged defect. In particular, the previous PAW expressions were spuriously sensitive to the pseudization conditions and this artifact is removed by the background term. This PAW derivation also provides insights into the norm-conserving pseudopotential framework. We propose then an alternative definition for the total energy of charged cells and for the potential within this framework.

  16. Mechanism of increasing the thermal effect zone thickness in pulse periodic treatment of a target by an electron beam

    The factors determining the layer thickness growth in the thermal effect zone of a target, made of steel 45, in pulse periodic impact by low-energy high-current electron beam in the mode of initial melting are analyzed on the basis of numerical modeling of temperature fields. Conclusion is made that thickness growth is conditioned by scattering of the energy pulse density from pulse to pulse and by the availability of individual pulses with increase in the energy value. It is shown that change of steel thermophysical properties occurring by irradiation on the account of saturation of target near-surface area by carbon leads to thickness growth only of those layers of thermal effect zone which are formed in the former melt area. The target temperature dependence on the irradiated pulse number is measured and numerically calculated

  17. Prolonged urinary leakage in the postoperative period of renal hydatic cyst treatment with oral desmopressin: a case report

    Ceylan Cavit

    2012-10-01

    Full Text Available Abstract Introduction Prolonged extravasation after renal and ureter surgeries is a bothersome situation for both the patient and the doctor. It is usually related to the suture line not being watertight. The contact between urine and the edges of the wound also delay healing of the wound. In this situation, the first thing to do is to break the contact between the wound and the urine by inserting an adequate stent. Sometimes, this process is not enough. We approached this problem with a different treatment method for a case involving prolonged drainage. Case presentation A 52-year-old Caucasian woman who presented at our clinic with right flank pain was operated on due to a renal hydatic cyst, and cyst removal was performed. On follow-up, prolonged urinary leakage was observed and a desmopressin treatment was started on the patient. Drainage was greatly reduced after desmopressin was started and there was no drainage on the fifth day. Conclusion Prolonged extravasation is a bothersome situation and there can be many reasons for this. Whenever traditional approaches are not enough, oral desmopressin therapy can be started reliably if there are no contraindications for the patient. Eventually, contact between urine and the suture site will cease and therefore the fever and healing time will be shortened.

  18. Cardiac atrial circadian rhythms in PERIOD2::LUCIFERASE and per1:luc mice: amplitude and phase responses to glucocorticoid signaling and medium treatment.

    Daan R van der Veen

    Full Text Available Circadian rhythms in cardiac function are apparent in e.g., blood pressure, heart rate, and acute adverse cardiac events. A circadian clock in heart tissue has been identified, but entrainment pathways of this clock are still unclear. We cultured tissues of mice carrying bioluminescence reporters of the core clock genes, period 1 or 2 (per1(luc or PER2(LUC and compared in vitro responses of atrium to treatment with medium and a synthetic glucocorticoid (dexamethasone [DEX] to that of the suprachiasmatic nucleus (SCN and liver. We observed that PER2(LUC, but not per1(luc is rhythmic in atrial tissue, while both per1(luc and PER2(LUC exhibit rhythmicity in other cultured tissues. In contrast to the SCN and liver, both per1(luc and PER2(LUC bioluminescence amplitudes were increased in response to DEX treatment, and the PER2(LUC amplitude response was dependent on the time of treatment. Large phase-shift responses to both medium and DEX treatments were observed in the atrium, and phase responses to medium treatment were not attributed to serum content but the treatment procedure itself. The phase-response curves of atrium to both DEX and medium treatments were found to be different to the liver. Moreover, the time of day of the culturing procedure itself influenced the phase of the circadian clock in each of the cultured tissues, but the magnitude of this response was uniquely large in atrial tissue. The current data describe novel entrainment signals for the atrial circadian clock and specifically highlight entrainment by mechanical treatment, an intriguing observation considering the mechanical nature of cardiac tissue.

  19. Cardiac Atrial Circadian Rhythms in PERIOD2::LUCIFERASE and per1:luc Mice: Amplitude and Phase Responses to Glucocorticoid Signaling and Medium Treatment

    Xi, Yang; Li, Lei; Duffield, Giles E.

    2012-01-01

    Circadian rhythms in cardiac function are apparent in e.g., blood pressure, heart rate, and acute adverse cardiac events. A circadian clock in heart tissue has been identified, but entrainment pathways of this clock are still unclear. We cultured tissues of mice carrying bioluminescence reporters of the core clock genes, period 1 or 2 (per1luc or PER2LUC) and compared in vitro responses of atrium to treatment with medium and a synthetic glucocorticoid (dexamethasone [DEX]) to that of the suprachiasmatic nucleus (SCN) and liver. We observed that PER2LUC, but not per1luc is rhythmic in atrial tissue, while both per1luc and PER2LUC exhibit rhythmicity in other cultured tissues. In contrast to the SCN and liver, both per1luc and PER2LUC bioluminescence amplitudes were increased in response to DEX treatment, and the PER2LUC amplitude response was dependent on the time of treatment. Large phase-shift responses to both medium and DEX treatments were observed in the atrium, and phase responses to medium treatment were not attributed to serum content but the treatment procedure itself. The phase-response curves of atrium to both DEX and medium treatments were found to be different to the liver. Moreover, the time of day of the culturing procedure itself influenced the phase of the circadian clock in each of the cultured tissues, but the magnitude of this response was uniquely large in atrial tissue. The current data describe novel entrainment signals for the atrial circadian clock and specifically highlight entrainment by mechanical treatment, an intriguing observation considering the mechanical nature of cardiac tissue. PMID:23110090

  20. Eyelid hygiene as a tool for prevention and treatment of complications due to ocular surface diseases in early post-LASIK period

    V. V. Kurenkov; A. V. Zhemchugova; L. G. Polunina; N. I. Martirosova

    2014-01-01

    Purpose: to analyze the effect of eyelid hygiene and therapy on early post-op period following excimer laser refractive surgery.Methods: 144 patients (288 eyes) aged 18-57 yrs who underwent excimer laser vision correction (LASIK) were followed. All patients were divided into two groups depending on therapy. In treatment group (70 patients/140 eyes), eyelid hygiene was prescribed 7 days before and 7 days again following refractive surgery for 1 or 2 months. In control group (74 patients/148 ey...

  1. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period

    Maria-Angeliki Gkini

    2014-01-01

    Full Text Available Background: Platelet-rich plasma (PRP is defined as an autologous concentration of plasma with a greater count of platelets than that of whole blood. Its action depends on the released growth factors from platelets. It has been investigated and used in numerous fields of medicine. Recently, PRP has received growing attention as a potential therapeutic tool for hair loss. Aims: To evaluate the efficacy and safety of PRP injections in the scalp of patients with androgenetic alopecia. Settings and Design: Prospective cohort study. Materials and Methods: 20 patients, 18 males and 2 females, with androgenetic alopecia were enrolled in the study. PRP was prepared using a single spin method (Regenlab SA. Upon activation, it was injected in the androgen-related areas of scalp. Three treatment sessions were performed with an interval of 21 days and a booster session at 6 months following the onset of therapy. Statistical Analysis: Statistical analysis of the data was performed using the Statistical Package for the Social Sciences (SPSS, version 19.0 (IBM, NY, USA. Results: Hair loss reduced and at 3 months it reached normal levels. Hair density reached a peak at 3 months (170.70 ± 37.81, P < 0.001. At 6 months and at 1 year, it was significantly increased, 156.25 ± 37.75 (P < 0.001 and 153.70 ± 39.92 (P < 0.001 respectively, comparing to baseline. Patients were satisfied with a mean result rating of 7.1 on a scale of 1-10. No remarkable adverse effects were noted. Conclusions: Our data suggest that PRP injections may have a positive therapeutic effect on male and female pattern hair loss without remarkable major side effects. Further studies are needed to confirm its efficacy.

  2. Mortality and loss-to-follow-up during the pre-treatment period in an antiretroviral therapy programme under normal health service conditions in Uganda

    Levin Jonathan

    2009-08-01

    Full Text Available Abstract Background In many HIV programmes in Africa, patients are assessed clinically and prepared for antiretroviral treatment over a period of 4–12 weeks. Mortality rates following initiation of ART are very high largely because patients present late with advanced disease. The rates of mortality and retention during the pre-treatment period are not well understood. We conducted an observational study to determine these rates. Methods HIV-infected subjects presenting at The AIDS Support Clinic in Jinja, SE Uganda, were assessed for antiretroviral therapy (ART. Eligible subjects were given information and counselling in 3 visits done over 4–6 weeks in preparation for treatment. Those who did not complete screening were followed-up at home. Survival analysis was done using poisson regression. Results 4321 HIV-infected subjects were screened of whom 2483 were eligible for ART on clinical or immunological grounds. Of these, 637 (26% did not complete screening and did not start ART. Male sex and low CD4 count were associated independently with not completing screening. At follow-up at a median 351 days, 181 (28% had died, 189 (30% reported that they were on ART with a different provider, 158 (25% were alive but said they were not on ART and 109 (17% were lost to follow-up. Death rates (95% CI per 100 person-years were 34 (22, 55 (n.18 within one month and 37 (29, 48 (n.33 within 3 months. 70/158 (44% subjects seen at follow-up said they had not started ART because they could not afford transport. Conclusion About a quarter of subjects eligible for ART did not complete screening and pre-treatment mortality was very high even though patients in this setting were well informed. For many families, the high cost of transport is a major barrier preventing access to ART.

  3. Brain metastases of solid tumour. Treatment distribution and analysis of survival in the period 1/01/2004 to 31/12/2008

    Objective: To retrospectively analyze the characteristics, treatments and survival analysis in patients with solid tumors with brain metastases (E IV) assisted in Unit Neuro-Oncology over a period of five years. Patients and methods: The records of patients (pts) with diagnosis of brain metastases from solid tumors assisted in Neuro-Oncology Unit, from 1/01/2004 and 31/12/2008. Results: 51 new patients carriers of brain metastases were treated with solid tumors. The median age at diagnosis was 57 years, ranging from 30 to 75. They corresponded to the male 37 and female 14 ratio 2.5 / 1. The majority was presented as metastases 31/51. The location was in the supratentorial region in 27 cases, posterior fossa in 11 and 13 were supra and infratentorial. In only 5 patients cranial MRI was performed in only one case and it changed the therapeutical strategy. In 35 patients he corresponded to the lung primary tumor (CBP), following cancer renal (5/51). Within the CBP, the most common histologic subtypes were to large cells and adenocarcinomas, 11 and 10, respectively. In 32 patients were not found dissemination elsewhere. Surgery + RT was performed in 30 cases, in 11 exclusive RT, exclusive surgery in 4 and 3 patients symptomatic treatment. In 39 cases did not Systemic treatment diagnosis. When a progression was only diagnosed It could make systemic treatment 5 pts. The median survival was 15.4 weeks (1-301 weeks). Conclusions: Lung cancer is the most common source of metastases brain, with a poor survival. The results of other characteristics patients, systemic treatments performed and survival according to the treatments performed will be presented during the congresss

  4. Comparison of different combined treatment processes to address the source water with high concentration of natural organic matter during snowmelt period

    Pengfei Lin; Xiaojian Zhang; Jun Wang; Yani Zeng; Shuming Liu; Chao Chen

    2015-01-01

    The source water in one forest region of the Northeast China had very high natural organic matter (NOM) concentration and heavy color during snowmelt period.The efficiency of five combined treatment processes was compared to address the high concentration of NOM and the mechanisms were also analyzed.Conventional treatment can hardly remove dissolved organic carbon (DOC) in the source water.KMnO4 pre-oxidization could improve the DOC removal to 22.0%.Post activated carbon adsorption improved the DOC removal of conventional treatment to 28.8%.The non-sufficient NOM removal could be attributed to the dominance of large molecular weight organic matters in raw water,which cannot be adsorbed by the micropore upon activated carbon.O3 + activated carbon treatment are another available technology for eliminating the color and UV254 in water.However,its performance of DOC removal was only 36.4%,which could not satisfy the requirement for organic matter.The limited ozone dosage is not sufficient to mineralize the high concentration of NOM.Magnetic ion-exchange resin combined with conventional treatment could remove 96.2% of color,96.0% of UV254 and 87.1% of DOC,enabling effluents to meet the drinking water quality standard.The high removal efficiency could be explained by the negative charge on the surface of NOM which benefits the static adsorption of NOM on the anion exchange resin.The results indicated that magnetic ion-exchange resin combined with conventional treatment is the best available technology to remove high concentration of NOM.

  5. Periodic functions with variable period

    Pryjmak, M. V

    2010-01-01

    The examples of rhythmical signals with variable period are considered. The definition of periodic function with the variable period is given as a model of such signals. The examples of such functions are given and their variable periods are written in the explicit form. The system of trigonometric functions with the variable period is considered and its orthogonality is proved. The generalized system of trigonometric functions with the variable period is also suggested; some conditions of it...

  6. ASME N511-19XX, Standard for periodic in-service testing of nuclear air treatment, heating, ventilating and air conditioning systems

    NONE

    1997-08-01

    A draft version of the Standard is presented in this document. The Standard covers the requirements for periodic in-service testing of nuclear safety-related air treatment, heating, ventilating, and air conditioning systems in nuclear facilities. The Standard provides a basis for the development of test programs and does not include acceptance criteria, except in cases where the results of one test influence the performance of other tests. The Standard covers general inspection and test requirements, reference values, inspection and test requirements, generic tests, acceptance criteria, in-service test requirements, testing following an abnormal incident, corrective action requirements, and quality assurance. Mandatory appendices provide a visual inspection checklist and four test procedures. Non-mandatory appendices provide additional information and guidance on mounting frame pressure leak test procedure, corrective action, challenge gas substitute selection criteria, and test program development. 8 refs., 10 tabs.

  7. Study of toxicity of Samarium-153-EDTMP in the treatment of painful skeletal metastasis. Final report for the period 15 December 1996 - 14 December 1997

    Favourable characteristics of Sm-153 EDTMP make it an effective agent for use in the palliative treatment of metastatic bone pain. It has also been postulated that Sm-153 might have some tumoricidal effect. But until today its mechanism of action in the treatment of skeletal metastasis is not known. This experimental study has been designed to study the cellular and molecular changes occurring in the bone tumour cells (osteosarcoma of femur of wister rats) following irradiation with different doses of Sm-153 EDTMP. Experimental osteosarcorna tumour cells were harvested and treated with Sm-153 EDTMP over different periods of time ranging from 1-24 hours. Electron microscope, fluorescence microscope, MTI assay and 3HTdR release assay studies were conducted to observe for effects of radiation. Sm-153 EDTMP irradiation of bone tumour cells resulted in significant nuclear fragmentation, margination of condensed chromatin, marked pyknosis and increased formation of membrane bounded apoptotic bodies formation. The quantification analysis of fragmented DNA for bone tumour cells induced by Sm-153 EDTMP showed that the DNA fragmentation was enhanced with prolongation of irradiation time. The inhibition rate of proliferation of bone tumour cells as well as DNA fragmentation in bone tumour cells after irradiation with Sm-153 EDTMP increased significantly and progressively with prolongation of irradiation time, reaching levels of 63% and 78% respectively by 24 hours. (author)

  8. Kerathocyst odontogenic tumor: Importance of selection the best treatment modality and a periodical follow-up to prevent from recurrence: A case report and literature review

    Nasim Jafaripozve

    2013-01-01

    Full Text Available The keratocystic odontogenic tumor (KCOT is a relatively common oral and maxillofacial lesion with specific characteristics such us rapid growth, extension into the surrounding tissues and high rates of recurrence. Various treatment modalities have been reported. Due to the very thin and friable lining characteristic of the tumor, enucleation can be difficult undertaken and for this reason it is associated with the highest recurrence rates. A 22-year-old male referred to our clinic due to a slight expansion in the right mandible from 2 years ago. He has a history of occurrence of KCOT in this region that was treated surgically by enucleation and curettage 5 years ago. Cone beam computed tomography showed a multilocular radiolucent lesion that extended from the angle of the mandible to the symphysis. Incisional biopsy showed a KCOT recurrence that surgically treated with resection of the right mandible by continuity preservation. Selection of the best treatment modality and also a periodical lifelong follow-up is very important to reduce the rate of recurrence and morbidity of the patient.

  9. Effect of estradiol, vitamin A, E and selenium treatment with varying sexual rest period on recovery rate in cross-bred cows with chronic endometritis

    Dipyaman Sengupta

    2013-04-01

    Full Text Available Aim:This work was done to study the effect of vitamin A, E and Se with varying sexual rest period in cross-bred cows with chronic endometritis. Materials and Methods: Cross-bred cows (n=396 from different villages of West Bengal with purulent or muco-purulent discharge with a history of infertility and repeat breeding for 3 to 6 months were chosen for the present study. These cows received uterine wash with lugol's iodine, intra-uterine and parenteral antibiotics and de-worming as general treatment. They were then divided into six groups viz. SR12 × EV (n=59, SR12 × Control (n=67, SR21 × EV (n=65, SR21 × Control (n=70, SR24 × EV (n=66, SR24 × Control (n=69 receiving sexual rest of 12 (SR12, 21 (SR21 and 24 (SR24 days with (EV group or without (control estradiol + vitamin A, E and Se. Results: The results indicate that the recovery rate of EV and control group was 76.27 % and 37.31 % respectively (P<0.01 in SR 12, 72.31 % and 47.14 % respectively (P<0.01 in SR 21 and 92.41 % and 63.77 % respectively (P<0.01 in SR 24. SR 24 showed significantly better (P<0.01 recovery rate compared to SR 12 and SR 21. Lowest recovery and conception rate of EV and control group in SR 12 might be due to insufficient time for the recovery of endometrium. Conclusion: The results indicate that parenteral and intra-uterine antibiotics had synergistic effect with estradiol, vitamin A, E and Se treatment in recovery from endometritis, though a minimum time interval is required for complete recovery of the endometrium for best conception rate. [Vet World 2013; 6(2.000: 106-108

  10. Analysis of rehabilitation treatment and nursing of stroke recovery period%中风恢复期的康复治疗及护理分析

    吴凤鸣

    2016-01-01

    目的:分析中风恢复期的康复治疗及护理方法。方法:选取我院在2012年3月~2014年3月收取的中风恢复期患者80例,并对其进行对应的康复治疗和护理。结果:康复治疗后,患者的生活自理能力明显提高,入院时患者生活自理能力评分是(1.3±1.1)分;入院后一个月,评分为(8.8±3.5)分;入院后半年,评分为(13.2±4.1)分。所以治疗的前后差异对比有统计学意义(P<0.05)。结论:对中风恢复期的患者实施对应的康复治疗和护理是必要的,可以加速提升患者的自理能力和生活质量。值得临床推广使用。%Objective To analyze the rehabilitation and nursing of stroke recovery. Methods Choose from March 2012 to March 2014 to collect 80 cases of patients with stroke recovery period, carry on the corresponding rehabilitation treatment and nursing.Results After rehabilitation, self-care ability of patients significantly improved patient admission daily living score was (1.3 ± 1.1) points; one month after admission, a score of (8.8 ± 3.5) points; six months after admission, scoring was (13.2 ± 4.1) points. So the difference before and after treatment was statistically significant comparison (P <0.05).Conclusion The implementation of recovery for stroke patients corresponding rehabilitation treatment and care is necessary, can be accelerated to enhance self-care ability and quality of life of patients. Worthy of clinical use.

  11. Radical hysterectomy in surgical treatment of invasive cervical cancer at the Department of gynecology and obstetrics in Novi Sad in the period 1993-2013.

    Đurđević Srđan

    2015-01-01

    Full Text Available Introduction. During the period from 1993 - 2013, 175 women with invasive cervical cancer underwent radical hysterectomy sec. Wertheim-Meigs at the Department of Gynecology and Obstetrics, Clinical Center of Vojvodina in Novi Sad. Indications for radical hysterectomy comprise histopathologically confirmed invasive cervical cancer in stages I B 1 - II B according to the International Federation of Gynecology and Obstetrics. Material and Methods. Stage of the disease or extent of the disease spread to the adjacent structures was assessed in accordance with the International Federation of Gynecology and Obstetrics staging system from 2009. Exclusion criteria were all other stages of this disease: I A and stages higher than II B, as well as the absence of definite histological confirmation of the cervical cancer (primary endometrial or vaginal cancer which infiltrates the uterine cervix. Prior the operation, the following had to be done: the imaging of pelvis and abdomen, chest X-ray in two directions, electrocardiography, internist and anesthesiological examination. Results. The patients’ age ranged from 24-79 years (x : 46 years, and the operation duration was 120-300 minutes (x : 210 min.. Stage I B 1 was found in 64.6% of operated patients, 14.8% of the patients were in stage I B 2, 9.1% were in stage II A and 11.4 % were in stage II B. Blood loss during the operation ranged from 50-800 ml (on average 300 ml, and the number of removed lymph nodes per operation was 14-75 (x : 32. Intraoperative and postoperative complications developed in 6.8% of and 17.7% of patients, respectively. Recurrence was reported in 22 (12.5% patients, most often in paraaortic lymph nodes (3.4% and parametria (2.8%, while the overall 5-year survival rate was 87% until 2008. Concluision. Wertheim-Meigs radical hysterectomy is a basic surgical technique for the treatment of initial stages of invasive cervical cancer.

  12. Surgical treatment of 137 cases with chronic subdural hematoma at the university clinical center of Kosovo during the period 2008–2012

    Mekaj, Agon Y.; Morina, Arsim A.; Mekaj, Ymer H.; Manxhuka-Kerliu, Suzana; Miftari, Ermira I.; Duci, Shkelzen B.; Hamza, Astrit R.; Gashi, Musli M.; Xhelaj, Mentor R.; Kelmendi, Fatos M.; Morina, Qamile Sh.

    2015-01-01

    Background: Chronic subdural hematoma (CSDH) is frequent pathology in neurosurgical practice. The aim of this study is to present the first series of patients with CSDH, who got surgically treated in Clinic of Neurosurgery, University Clinical Center of Kosovo. Materials and Methods: This is a retrospective study that included 137 patients with CSDH who had been treated during the period 2008–2012. The data were collected and analyzed from the archives and protocols of the University Clinical Center of Kosovo. Patients were analyzed in many aspects such as age, gender, etiological factors, clinical features, localization, diagnoses, methods of surgical interventions, recurrences and mortality of patients. Results: From 137 patients with CSDH, 106 (77.3%) were males and 31 (22.7%) females. Average age of patients was 62.85 years. Analyzed according to the decades, the highest number of causes with CSDH was between 70 and 79 years (46%). The head trauma has been responsible for CSDH in 88 patients (64.3%), while the main symptom was headache (92 patients or 67.1%). One burr-hole trepanation with closed drainage system has been used in majority of cases (in 101 patients or 73.7%). The recurrence of CSDH was 6.5%, whereas mortality 2.9%. Conclusion: CSDH is more common in elderly patients. The male-female ratio is 3.4:1. Like other authors we also think that treatment with one burr-hole and drainage is a method of choice, because of its simplicity and safety. PMID:25883478

  13. Surgical treatment of 137 cases with chronic subdural hematoma at the university clinical center of Kosovo during the period 2008-2012

    Agon Y Mekaj

    2015-01-01

    Full Text Available Background: Chronic subdural hematoma (CSDH is frequent pathology in neurosurgical practice. The aim of this study is to present the first series of patients with CSDH, who got surgically treated in Clinic of Neurosurgery, University Clinical Center of Kosovo. Materials and Methods: This is a retrospective study that included 137 patients with CSDH who had been treated during the period 2008-2012. The data were collected and analyzed from the archives and protocols of the University Clinical Center of Kosovo. Patients were analyzed in many aspects such as age, gender, etiological factors, clinical features, localization, diagnoses, methods of surgical interventions, recurrences and mortality of patients. Results: From 137 patients with CSDH, 106 (77.3% were males and 31 (22.7% females. Average age of patients was 62.85 years. Analyzed according to the decades, the highest number of causes with CSDH was between 70 and 79 years (46%. The head trauma has been responsible for CSDH in 88 patients (64.3%, while the main symptom was headache (92 patients or 67.1%. One burr-hole trepanation with closed drainage system has been used in majority of cases (in 101 patients or 73.7%. The recurrence of CSDH was 6.5%, whereas mortality 2.9%. Conclusion: CSDH is more common in elderly patients. The male-female ratio is 3.4:1. Like other authors we also think that treatment with one burr-hole and drainage is a method of choice, because of its simplicity and safety.

  14. Heavy Slow Resistance Versus Eccentric Training as Treatment for Achilles Tendinopathy

    Beyer, Rikke; Kongsgaard, Mads; Hougs Kjær, Birgitte;

    2015-01-01

    BACKGROUND: Previous studies have shown that eccentric training has a positive effect on Achilles tendinopathy, but few randomized controlled trials have compared it with other loading-based treatment regimens. PURPOSE: To evaluate the effectiveness of eccentric training (ECC) and heavy slow...... resistance training (HSR) among patients with midportion Achilles tendinopathy. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. METHODS: A total of 58 patients with chronic (>3 months) midportion Achilles tendinopathy were randomized to ECC or HSR for 12 weeks. Function and symptoms...... tendinopathy and that the latter tends to be associated with greater patient satisfaction after 12 weeks but not after 52 weeks....

  15. Postnatal development and neoplastic disease pattern in NMRI mice after combined treatment with ethylnitrosourea and X-irradiation on different days of the fetal period.

    Wiggenhauser, A; Schmahl, W

    1987-06-01

    Mice were X-irradiated on day 14, 15 or 16 of gestation with 1.0 Gy. This did not result in an increased tumour frequency in the offspring until 12 months. Mice treated with ethylnitrosourea (ENU) (45 mg/kg) on these gestation days developed a significantly increased tumour frequency in the lungs and liver, and in the ovaries after treatment on day 15 of gestation. Additionally this experiment was the first to show that ENU treatment on gestation day 14, 15 or 16 results in haemangiosarcomas of the subcutis at a low incidence (2.0, 2.4, 2.6 per cent). After combined treatment with these two agents in the sequence X+ENU and an interval of 4 h, a significantly increased incidence rate of animals with tumours was observed in the offspring treated on gestation day 14 or 16. Moreover, the treatment on gestation day 16 exhibited the highest tumour frequency per examined animal (5.7) of all treatment groups. This result is due to a relatively uniform increase of all tumor types. Within this pattern, the frequency of liver tumours was most marked. The diagnosed liver tumours were significantly augmented after X+ENU treatment on day 16. In the reverse sequence (ENU+X), the total tumour outcome was not significantly altered compared with the effects of ENU alone. However, detailed analysis also showed a significant augmentation of the liver tumour frequency with treatment on day 15. PMID:3496295

  16. Postnatal development and neoplastic disease pattern in NMRI mice after combined treatment with ethylnitrosourea and X-irradiation on different days of the fetal period

    Wiggenhauser, A.; Schmahl, W.

    1987-06-01

    Mice were X-irradiated on day 14, 15 or 16 of gestation with 1.0 Gy. This did not result in an increased tumour frequency in the offspring until 12 months. Mice treated with ethylnitrosourea (ENU) (45 mg/kg) on these gestation days developed a significantly increased tumour frequency in the lungs and liver, and in the ovaries after treatment on day 15 of gestation. Additionally this experiment was the first to show that ENU treatment on gestation day 14, 15 or 16 results in haemangiosarcomas of the subcutis at a low incidence (2.0, 2.4, 2.6%). After combined treatment with these two agents in the sequence X + ENU and an interval of 4 h, a significantly increased incidence rate of animals with tumours was observed in the offspring treated on gestation day 14 or 16. Moreover, the treatment on gestation day 16 exhibited the highest tumour frequency per examined animal (5.7) of all treatment groups. This result is due to a relatively uniform increase of all tumor types. Within this pattern, the frequency of liver tumours was most marked. The diagnosed liver tumours were significantly augmented after X + ENU treatment on day 16. In the reverse sequence (ENU + X), the total tumour outcome was not significantly altered compared with the effects of ENU alone. However, detailed analysis also showed a significant augmentation of the liver tumour frequency with treatment on day 15.

  17. A comparative study on the adverse effects of two anti-tuberculosis drugs regimen in initial two-month treatment period

    Begum Lutfun Nahar, A.K.M. Mosharrof Hossain, M. Monirul Islam and Dipti Rani Saha

    2006-01-01

    Tuberculosis (TB) is a leading cause of death throughout the world and Bangladesh stands 4th among high burden countries. Treatment of TB hampered with poor patient compliance and intolerance at least partly due to the adverse drug reactions.A prospective longitudinal non-randomized case study was conducted on 64 admitted patients in Chest Disease Hospital and Shahid Shamsuddin Hospital, Sylhet diagnosed as primary (Category I) and resistant or treatment failure (Category II) to compare adve...

  18. Surgical Treatment of 55 Patients with Pressure Ulcers at the Department of Plastic and Reconstructive Surgery Kosovo during the Period 2000–2010: A Retrospective Study

    Shkelzen B. Duci; Hysni M. Arifi; Selmani, Mimoza E.; Mekaj, Agon Y.; Musli M Gashi; Buja, Zejn A; Ismajli, Vildane H.; Kllokoqi, Adem N.; Enver T. Hoxha

    2013-01-01

    Objective. The objective of this study is to determine the incidence of PUs, the distribution of PUs, common injuries contributing to the occurrence of PUs in patients admitted to the Department of Plastic and Reconstructive Surgery Kosovo for surgical interventions of PUs, localization of PUs in body, the topical treatment of pressure ulcers before surgical intervention, the methods of surgical interventions, number of surgical interventions, duration of treatment, complications, and mortali...

  19. Effect of 131I in the treatment of hyperthyroidism at Hospital San Juan de Dios for the period from January 1, 2005 to December 31, 2007

    Radioactive iodine 131 (131I) is used for the treatment of hyperthyroidism at Hospital San Juan de Dios. The most common causes of hyperthyroidism have been Graves disease or diffuse goiter, toxic multinodular goiter and toxic nodular goiter, among others; but, the results are unknown and factors that have influenced the treatment with 131I. The study has included only patients with these causes, and have been administered radioactive iodine 131 as treatment. 180 cases have been treated with radioactive iodine, 75.0% have presented diffuse goiter, 22.2% multinodular goiter and 2.8% nodular goiter, where were been 144 female patients (80%) and 36 male patients (20%). Women have had predominance in the three groups that were analyzed pathologies, according to medical literature, an approximate incidence of 0.4 cases has existed per thousand women to year. A proportional relationship between clinical size of goiter and failure of therapy with 131I has been in diffuse goiter for the handling of hyperthyroidism. Likewise, male sex has been risk factor in the failure of such therapy. Multinodular goiter and nodular goiter have not had difference between the results according to sex and size of goiter. Most hyperthyroid patients with diffuse goiter, nodular and multinodular have received 131I as treatment, and previously this, they have received propylthiouracil; treatment outcome was unaffected. Treatment with 131I in hyperthyroid patients has managed to be effective for reduction in size of the thyroid gland in diffuse goiter, nodular goiter and multinodular

  20. Mortality by treatment in patients ≥80 years of age with gastroesophageal cancer seen in a 20-year period at a single medical center

    Mason, James; Maldonado, Yolanda Munoz; Wong, Lucas

    2015-01-01

    The treatment approach to patients 80 years of age and older with gastroesophageal cancer at Baylor Scott and White in Temple, Texas, has historically favored conservative measures in the form of palliation and observation. To evaluate this trend in practice, the administered treatments and subsequent patient outcomes of this group were retrospectively reviewed. The study group included all patients 80 years of age and older with a diagnosis of gastroesophageal cancer seen at our facility between 1991 and 2010. Of the 117 cases, 49% received none of the available treatment modalities. The median overall survival (OS) of patients who received treatment, however, was significantly longer than the OS of those who did not, regardless of modality. Specifically, surgical intervention offered an almost double median OS compared with no therapy (6.8 vs. 3.9 months, respectively; P = 0.02); chemotherapy, an almost 4-fold OS benefit (14.8 vs. 3.9 months; P = 0.03); and radiation therapy, a >3-fold OS benefit (11.1 vs. 3.5 months; P = 0.04). These results further substantiate chronological age as an inaccurate predictor of treatment benefit, and age alone should not dictate the administration or withholding of available treatment options. PMID:26130872

  1. Change in the direct cost of treatment for children and adolescents with hyperkinetic disorder in Germany over a period of four years

    Rothenberger Aribert

    2009-01-01

    Full Text Available Abstract Background In many developed countries, the treatment of hyperkinetic disorder (or ADHD consumes a considerable amount of resources. The primary aim of this study was to determine change in the direct cost of treatment for children and adolescents with hyperkinetic disorder in Germany over time, and compare the cost with the cost of treatment for two physical disorders: epilepsy and asthma. Methods The German Federal Statistical Office provided data on the direct cost of treating hyperkinetic disorder, epilepsy and asthma in Germany for 2002, 2004, and 2006. The direct costs of treatment incurred by hyperkinetic disorder in these years were compared with those incurred by epilepsy and asthma. Results The total direct cost of treatment for the hyperkinetic disorder was € 177 million in 2002, € 234 million in 2004, and € 341 million in 2006. The largest proportion of the cost was incurred by the age group Conclusion The direct cost of treatment for hyperkinetic disorder in the age group

  2. Thyrotoxic periodic paralysis

    A case of thyrotoxic periodic paralysis is reported in a Hispanic man with an unusual recurrence six weeks after radioactive iodine treatment. Thyrotoxic periodic paralysis has now been well characterized in the literature: it occurs primarily in Orientals with an overwhelming male preponderance and a higher association of specific HLA antigens. Clinical manifestations include onset after high carbohydrate ingestion or heavy exertion, with progressive symmetric weakness leading to flaccid paralysis of the extremities and other muscle groups, lasting several hours. If hypokalemia is present, potassium administration may help abort the attack. Although propranolol can be efficacious in preventing further episodes, the only definitive treatment is establishing a euthyroid state. The pathophysiology is still controversial, but reflects altered potassium and calcium dynamics as well as certain morphologic characteristics within the muscle unit itself

  3. Postnatal development and neoplastic disease pattern in NMRI-mice after combined treatment with ethylnitrosourea and X-irradiation on different days of the fetal period

    Mice were X-irradiated on either day 14, 15, or 16 of gestation with 1,0 Gy. This did not result in an increased tumor frequency in offspring until 12 months. Mice treated parallelly with ENU (45 mg/kg) on the same gestation days developed a significantly increased tumor frequency of the lungs and the liver in all treated groups, and of the ovaries after treatment on day 15 of gestation. This experiment was the first to show that ENU-treatment resulted in hemangiosarcomas of the subcutis at a low incidence. After combined treatment in the sequence X+ENU and an interval of 4 hours, increased tumor frequency was observed only in the offspring treated on gestation day 16. The diagnoses liver tumors and hemangiosarcomas were significantly augmented after X+ENU-treatment on day 15 and 16 and day 14 and 16, respectively. In the reverse sequence (ENU+X) the total tumor outcome was not significantly altered in comparison with the effects of ENU alone. However, detailed analysis also showed a synergistic action on liver tumor frequency on days 15 and 16. (orig./ECB)

  4. Clinical efficacy of recombinant human endostatin combined with FOLFOX4 in the treatment of later period episode patients of colorectal cancer

    Jie Zhang; Juan Wen; Yong-Gang Lu

    2015-01-01

    Objective:To observe the effects of recombinant human endostatin (recombinant human endostatin, Endostar) combined with FOLFOX4 regimen in the treatment of advanced node rectal cancer (colon and as cancer, CRC) of clinical efficacy and adverse reactions.Methods:253 patients with advanced colorectal cancer were randomly divided into observation group and control group, 126 cases in observation group and 127 cases in control group. The control group was treated with FOLFOX4, and the observation group was treated with recombinant human endostatin combined with FOLFOX4 regimen. To compare the short-term efficacy, quality of life and adverse reactions of the two groups.Results:the observation group and the control group total effective rate (ORR) were 60.32% and 43.31%, the difference was statistically significant; group two, disease control rate (DCR) were 81.75% and 70.87%, the difference was statistically significant; the first CRC patients, the observation group and the control group the PR rate was statistically significant; relapse patients, observation group and control group CR, PD, ORR and DCR rate were statistically significant;Conclusion: the use of recombinant human endostatin combined with FOLFOX4 regimen in the treatment of first-episode patients with advanced colorectal cancer, not obvious to improve curative effect; for patients with advanced relapsed, combination therapy is better than pure FOLFOX4 treatment; combination therapy in improving the quality of life and chemotherapy combined treatment had no significant difference; no serious adverse reaction, good safety, and has potential clinical application.

  5. Glycopyrronium bromide for the treatment of chronic obstructive pulmonary disease.

    Riario-Sforza, Gian Galeazzo; Ridolo, Erminia; Riario-Sforza, Edoardo; Incorvaia, Cristoforo

    2015-02-01

    Glycopyrronium bromide is a new long-acting muscarinic antagonist to be used once-daily, which is approved as a bronchodilator for the symptomatic maintenance treatment of adult patients with chronic obstructive pulmonary disease (COPD). In the Glycopyrronium bromide in chronic Obstructive pulmonary disease airWays trials, treatment with inhaled glycopyrronium bromide at 50 μg once daily achieved a significantly better lung function than placebo, as measured by the trough forced expiratory volume in 1 s in patients with moderate-to-severe COPD. The lung function improvement was maintained for up to 52 weeks. Other improved indexes were dyspnea scores, health status, exacerbation rates and time of exercise endurance. Studies comparing the efficacy of glycopyrronium versus tiotropium bromide found substantial equivalence of the two drugs. Glycopyrronium was generally well tolerated. These data add inhaled glycopyrronium bromide to the treatment of patients with moderate to severe COPD as an effective once-daily LAMA. PMID:25547422

  6. Effect of estradiol, vitamin A, E and selenium treatment with varying sexual rest period on recovery rate in cross-bred cows with chronic endometritis

    Dipyaman Sengupta; Pramod R. Nandi

    2013-01-01

    Aim:This work was done to study the effect of vitamin A, E and Se with varying sexual rest period in cross-bred cows with chronic endometritis. Materials and Methods: Cross-bred cows (n=396) from different villages of West Bengal with purulent or muco-purulent discharge with a history of infertility and repeat breeding for 3 to 6 months were chosen for the present study. These cows received uterine wash with lugol's iodine, intra-uterine and parenteral antibiotics and de-worming as general tr...

  7. The science conceptions of chemical textbooks addressed to the high school, in treatment of chemical kinetics during the period from 1929 to 2004

    Maria Eunice Ribeiro Marcondes

    2009-12-01

    Full Text Available This text is a part of the work that was developed based on the chemical kinetic theme and the target was how the scientific knowledge in this subject was used for high school textbooks, identifying the possible ideas about science related to these books. For that, based on the research developed by Níaz (1994 that used categories to represent the philosophical perspectives: the empirical/inductive and the rationalist, verifying which and how the concepts of science was inserted in the 20 Brazilians textbooks, edited in the period from 1929 to 2004.

  8. Impact of progesterone and estradiol treatment before the onset of the breeding period on reproductive performance of Bos indicus beef heifers.

    Sá Filho, M F; Nasser, L F T; Penteado, L; Prestes, R; Marques, M O; Freitas, B G; Monteiro, B M; Ferreira, R M; Gimenes, L U; Baruselli, P S

    2015-09-01

    The present aimed to develop a hormonal therapy based on the insertion of a progesterone (P4) insert (PI) during 10 d plus an estradiol injection (E2) at PI removal before the onset of breeding of beef heifers. In Exp. 1, the plasma P4 profile of prepubertal heifers showed that the insertion of a PI or 24 d previously used P4 insert (UPI) sustained plasma P4 above 1 ng/mL for at least the first 7 d of the treatment. In Exp. 2 there was no positive effect of additional estradiol benzoate (EB) administered at the insertion of UPI on the proportion of heifers with a corpus luteum (CL/Treated) 30 d after UPI removal [UPI + EB = 85.3%(a) (n = 134); EB + UPI + EB = 80.8%(a) (n = 125)]; however, both were greater (P heifer (P/Treated) following artificial insemination (AI) upon estrus detection was achieved when EC was applied [Control = 20.2%(b); UPI = 29.2%(ab); UPI + EB = 26.6%(b); UPI + EC = 36.7%(a)]. In Exp. 4, the treatment prior to the timed AI (TAI) tended to improve pregnancy per TAI [P/AI; Control 43.6% (n = 298) vs. UPI+EC 51.9% (n = 342); P = 0.08], but increased P/Treated [26.5% vs. 43.3%; P heifers. PMID:26169688

  9. Randomized, Double-Blind, Split-Face Study to Compare the Irritation Potential of Two Topical Acne Formulations Over a 21-Day Treatment Period.

    Kircik, Leon H; Bhatt, Varsha; Martin, Gina; Pillai, Radhakrishnan

    2016-02-01

    The use of fixed combinations in acne vulgaris (acne) is very common, however comparative clinical trial data are limited. Cutaneous tolerability can influence patient compliance, and concerns about skin irritation with topical acne treatments have lead to a number of comparative split-face studies. Recently, a new fixed combination product was introduced (clin 1.0%-BP 3.75% gel) that was shown to be effective in reducing both inflammatory and noninflammatory lesions in moderate to severe acne. Here, we assess the tolerability of clin 1.0%-BP 3.75% gel compared with adap 0.1%-BP 2.5% gel in healthy volunteers with no apparent facial redness or dryness over 21-days, using a split-face methodology. Especially over the first two weeks of treatment, clin 1.0%-BP 3.75% gel was more tolerable than adap 0.1%-BP 2.5% gel, with statistically significant differences in cumulative change from baseline starting as early as day 8 (dryness) and day 9 (erythema), and composite index on days 8-12 and 16. Transepidermal water loss was less with clin 1.0%-BP 3.75% gel, although the difference was not statistically significant. J Drugs Dermatol. 2016;15(2):178-182. PMID:26885785

  10. Treatment, therapy results and survival for non-small cell lung cancer in a period of new therapeutic modalities and cytotoxic substances

    During the last years considerable changes have been made in the treatment of non-small cell lung cancer. This retrospective study analyzed besides the common characteristics the treatment, response rates and overall survival of patients with non-small cell lung cancer in a central internistical and oncological outpatient department. 328 patients treated at the haematology-oncology outpatient department were included in this study. Requirements have been patients with histologically or cytologically verified non-small cell lung cancer, diagnosis between 1989 and 2001 and comprehensible courses of disease and treatment. Results: Most of the patients were men (72 %) and only 28 % were women. Median age at diagnosis was 61 years; 8.8 % of the patients were aged under 45 years. Adenocarcinoma (46 %) and squamous cell carcinoma (36 %) were the most frequent histologic types. At time of diagnosis 68 % of the patients have been in an already advanced stage IIIB or IV. Surprisingly the diagnosis resulted for 25 % of the patients by chance, 75 % of the patients were diagnosed due to symptoms. Only 8 % of the patients did not receive a specific therapy (surgery, radiation therapy, chemotherapy) due to their advanced disease. 21 patients were treated in a neoadjuvant setting and for 10 (48 %) surgery with curative intention could be performed. The most frequently given chemotherapy in the first-line palliative therapy were Cis-, Carboplatin/VP 16 (40 %) and Cis-, Carboplatin/Navelbine (27 %). The response rate was poor - six complete responses (2.5 %) and 34 (14.3 %) partial responses. 107 patients received a second-line chemotherapy. The overall median survival of all patients was 13.5 months. The stage at time of diagnosis was the most important prognostic factor. Interestingly enough also a survival benefit for women could be demonstrated (15.5 months vs. 13 months). The common characteristics of the analyzed patients correspond to the typical collective of patients in a

  11. Laser-induced interstitial thermotherapy (LITT) for treatment of uterine leiomyomas: 750 myomas were treated by LITT and the results over a five-year period are analyzed

    Chapman, Roxana

    1997-05-01

    Approximately 750 leiomyomas of 250 symptomatic patients were treated by LITT over a five-year period. Only 12% were lost to follow-up. Most were treated by a combination of the KTP/YAG laser, rarely by one or the other alone, and a few with the diode laser. The fiber optic was inserted 2 cm apart and, depending on the size of the tumor, 480 - 20,000 Joules were required. Most were treated laparoscopically but very large myomas were treated percutaneously under ultrasound control. Symptoms were nearly always relieved and the six failures were found to be due to unrecognized adenomyosis and other associated pathology. Half the patients complaining of infertility became pregnant and, in those whose only pathology had been leiomyomas it approached 90%. Vaginal delivery was not found to be contraindicated. Finally, oestrogen receptors and epidermal growth factor were found to be destroyed. It is concluded that LITT enables leiomyomas of all sizes and locations to be treated by a minimally invasive method with preservation of the uterus.

  12. 小城镇水污染治理设施建设期监管指标体系%Supervision Index System for Water Pollution Treatment Facilities during Construction Period in Small Towns

    方俊华; 陈薇; 邱忠莉

    2012-01-01

    With the increasing concerns of water pollution in small towns,the built rate of water pollution treatment facilities has increased in recent years,but the supervision of the water pollution treatment facilities during the construction period is often absent. Based on the analysis of the current situation and existing problems for the supervision of the water pollution treatment facilities, the paper developed the regulatory index system during the construction process using the empirical method, then determined the index system according to the expert advice, and finally obtained the order of the index weight using the analytic hierarchy process. The results showed that it is indispensable to conduct supervision during the construction period. Meanwhile, the development of the regulatory index system provides a definite supervision object for the water pollution treatment facilities during the construction period. The index weight provides guidance for determination of the key supervision object during the construction period.%随着我国小城镇水污染问题日趋严重,小城镇水污染治理设施的建成率在逐年提高,而对小城镇水污染治理设施建设过程的监管却存在缺失的问题.通过分析水污染治理设施监管现状及存在的问题,首先采用经验法对建设期监管指标体系进行构建,并通过征询专家意见确定指标体系,最后应用层次分析法确定各指标的权重排序.结果表明,对建设期进行监管是必要的,同时,监管指标体系的构建,使得水污染治理设施建设期的监管对象得以明确;指标权重的确定,对于管理者明确建设期的重点监管对象,具有一定的指导作用.

  13. 地榆粉辨证施治Ⅲ期压疮的效果分析%A clinical analysis of treating bedsore duringⅢ period by differential treatment with Diyu Fen

    周琳

    2016-01-01

    Objective: Clinical effects of Diyu Fen on bedsore duringⅢ period were investigated. Methods: 65 cases were randomly divided into two groups; the experimental group received Diyu Fen based on differential treatment; the control group was given conventional treatment. Clinical effcacy, healing time and cost of treatment in groups were compared. Results: In the experimental group, the cured was higher; the healing time was shorter; cost of treatment was lower; there were signiifcantly statistical differences (P<0.05). Conclusion: Treating bedsore duringⅢ period with Diyu Fen showed a good effect, was simple, inexpensive and worthy of promotion.%目的:探讨中药地榆粉辨证施治Ⅲ期压疮的临床疗效。方法:将65例Ⅲ期压疮患者随机分成两组,实验组采用地榆粉辨证施治;对照组采用常规治疗,比较两组在同一时间内的疗效、治愈时间及治疗费用。结果:实验组较对照组的治愈率高,治愈时间短,治疗费用低,两组比较差异有统计学意义(P<0.05)。结论:中药地榆粉辨证施治Ⅲ期压疮疗效好、方法简单、费用低,值得临床推广使用。

  14. Clindamycin Phosphate 1.2%/Tretinoin 0.025% Gel for the Treatment of Acne Vulgaris: Which Patients are Most Likely to Benefit the Most?

    Del Rosso, James Q.

    2015-01-01

    Clindamycin phosphate 1.2%/tretinoin 0.025% gel is a topical combination formulation used once daily for the treatment of acne vulgaris, with approval in the United States for patients >12 years of age. Three 12-week, randomized, vehicle-controlled, pivotal trials included > 1,800 actively treated subjects. In addition, an open-label, 52-week study was also completed with 442 subjects enrolled. The skin tolerability, safety, and efficacy of clindamycin phosphate 1.2%/tretinoin 0.025% gel appl...

  15. C linical observation of allylestrenol drug treatment of recurrent spontaneous abortion during different periods%烯丙雌醇在不同时期用药治疗复发性自然流产的效果观察

    叶飞雪; 田玉华

    2014-01-01

    Objective To analyze the clinical efficacy of allylestrenol treatment of recurrent spontaneous abortion during differ -ent periods .Mte hods Clinal data of 172 patients with recurrent spontaneous abortion were analyzed and the patients were divided into control group ( n =43 ) and the observation group ( n =129 ) according to different dosages .The control group was given ogesterone treatment,and the observation group was divided into three subgroups ( n =43,each)according to different drug treatment periods and received allylestrenol treatment .The drug giving periods of subgroup A , B, and C were after ovulation ,two weeks after conception ,three weeks after conception respectively .Clinical efficacy and term delivery rates of each group were compared .Results The total effective rate of observation subgroup A was higher than that of subgroup C ( P <0.01)and term delivery rates of observation group were higher than that of control group( P <0.01),term delivery rate of observation subgroup A was higher than that of subgroup B ( P <0.05)and C( P <0.01).Conclusion The best periods of allylestrenol treatment of recurrent spontaneous abortion is after ovulation ,which can improve clinical treatment outcomes and the success rate of term delivery .%目的:分析烯丙雌醇在不同时期用药治疗复发性自然流产的临床效果。方法选择172例复发性自然流产患者为研究对象,根据用药不同分为两组。对照组43例给予黄体酮治疗,观察组129例给予烯丙雌醇治疗。观察组又根据用药时间不同分为3组,各43例。观察A组、观察B组及观察 C组用药时间分别为排卵后、受孕后2周及受孕后3周。比较各组治疗效果及足月分娩率。结果观察A组总有效率高于对照组和观察C组( P <0.01);观察组足月分娩率高于对照组( P<0.01),其中观察A组足月分娩率高于观察B组( P <0.05)和观察C组( P <0.01)。结论烯丙雌醇治

  16. Benefit of intravenous antibiotic therapy in patients referred for treatment of neurologic Lyme disease

    Stricker RB

    2011-09-01

    Full Text Available Raphael B Stricker1,3, Allison K DeLong2, Christine L Green1,3, Virginia R Savely1,3, Stanley N Chamallas1,4, Lorraine Johnson1,31International Lyme and Associated Diseases Society, Bethesda, MD, USA; 2Center for Statistical Sciences, Brown University, Providence, RI, USA; 3California Lyme Disease Association, Marysville, CA, USA; 4QMedRx Inc, Maitland, FL, USABackground: We have shown previously that extended intravenous antibiotic therapy is associated with low morbidity and no mortality in patients referred for treatment of neurologic Lyme disease. In this study, we evaluated the benefit of extended intravenous antibiotic therapy in patients with symptoms of neurologic Lyme disease.Methods: Patients with significant neurologic symptoms and positive testing for Borrelia burgdorferi were treated with intravenous antibiotics, and biweekly evaluation of symptom severity was performed using a six-level ordinal scale. Four symptoms were selected a priori as primary outcome measures in the study, ie, fatigue, cognition, myalgias, and arthralgias. Patients were placed into five groups according to time on treatment (1–4, 5–8, 9–12, 13–24, and 25–52 weeks, and changes in the primary symptoms as a function of time on treatment were analyzed using a mixed-effects proportional odds model.Results: Among 158 patients with more than one follow-up visit who were monitored for up to 1 year, there were on average 6.7 visits per person (median 5, range 2–24. The last follow-up day was on average 96 days after enrollment (median 69, range 7–354 days, corresponding to the length of antibiotic therapy. Each primary symptom was significantly improved at one or more time points during the study. For cognition, fatigue, and myalgias, the greatest improvement occurred in patients on the longest courses of treatment (25–52 weeks with odds ratios (OR for improvement of 1.97 (P = 0.02, 2.22 (P < 0.01, and 2.08 (P = 0.01, respectively. In contrast

  17. Foot orthoses and physiotherapy in the treatment of patellofemoral pain syndrome: A randomised clinical trial

    Darnell Ross

    2008-02-01

    Full Text Available Abstract Background Patellofemoral pain syndrome is a highly prevalent musculoskeletal overuse condition that has a significant impact on participation in daily and physical activities. A recent systematic review highlighted the lack of high quality evidence from randomised controlled trials for the conservative management of patellofemoral pain syndrome. Although foot orthoses are a commonly used intervention for patellofemoral pain syndrome, only two pilot studies with short term follow up have been conducted into their clinical efficacy. Methods/design A randomised single-blinded clinical trial will be conducted to investigate the clinical efficacy and cost effectiveness of foot orthoses in the management of patellofemoral pain syndrome. One hundred and seventy-six participants aged 18–40 with anterior or retropatellar knee pain of non-traumatic origin and at least six weeks duration will be recruited from the greater Brisbane area in Queensland, Australia through print, radio and television advertising. Suitable participants will be randomly allocated to receive either foot orthoses, flat insoles, physiotherapy or a combined intervention of foot orthoses and physiotherapy, and will attend six visits with a physiotherapist over a 6 week period. Outcome will be measured at 6, 12 and 52 weeks using primary outcome measures of usual and worst pain visual analogue scale, patient perceived treatment effect, perceived global effect, the Functional Index Questionnaire, and the Anterior Knee Pain Scale. Secondary outcome measures will include the Lower Extremity Functional Scale, McGill Pain Questionnaire, 36-Item Short-Form Health Survey, Hospital Anxiety and Depression Scale, Patient-Specific Functional Scale, Physical Activity Level in the Previous Week, pressure pain threshold and physical measures of step and squat tests. Cost-effectiveness analysis will be based on treatment effectiveness against resource usage recorded in treatment logs and

  18. 3种处理方式对冬枣货架期品质的影响%Effects of Different Treatments on Storage Quality of Dongzao Jujube Fruits during Shelf-life Period

    武杰; 张引成; 李梅玲; 钱金

    2012-01-01

    In order to prolong the shelf life of Dongzao jujube fruits,the effects of three treatments were studied.Through the determination of respiration intensity,firmness,total soluble solids,vitamin C,ethylene release amount and ethanol production,effects of hot-water treatment,1-MCP and nano-package on the storage quality of Dongzao jujube fruits were studied during the shelf-life period.The results showed that all treatments could keep the storage quality of Dongzao jujube in some degree during the shelf-life period.The nano-package revealed the best effect on maintaining firmness,vitamin C content and fruit color,increasing total soluble solid amount,and inhibiting respiration rate,ethylene release amount and ethanol production.Therefore,nano-package could extend the shelf life of Dongzao jujube fruits up to 15 days.%以冬枣为试材,研究3种处理方式对其货架期品质的影响。通过测定冬枣的呼吸强度、硬度、总可溶性固形物、VC、乙烯释放量、乙醇积累等指标,研究热水浸泡、1-MCP熏蒸、纳米袋包装3种处理对冬枣果实的保鲜效果。结果表明:3种处理方法均不同程度保持了枣果货架期品质,其中纳米袋包装保鲜效果最佳,有效维持了冬枣果肉硬度和VC含量,延缓其色泽由绿到红的转变和总可溶性固形物上升,抑制了冬枣的呼吸强度及乙烯和乙醇的产生,货架期15d后,仍具有商品价值。

  19. 高压氧治疗各期糖尿病足间歇性跛行的疗效观察%Hyperbaric Oxygen Treatment of Diabetic Foot Every Period Curative Effect Observation of Intermittent Claudication

    于桂贤

    2015-01-01

    Objective To observe patients with hyperbaric oxygen treatment of diabetic foot every period of intermittent claudication.Methods Select 26 patients with diabetic foot, no burst but plantar skin dark purple 0 grade diabetic foot 7 cases, the foot has burst 19 cases, observation on foot pain. ResultsAfter hyperbaric oxygen therapy group, on foot pain signiifcantly prolong time data to compare the two groups have statistical signiifcance (P< 0.05). Ankle brachial index (ABI) and local skin temperature is improved. Blood glucose significantly lower after treatment. Ulcer healing in 11 cases, remaining signiifcant reduction, 8 cases of ulcer surface can avoid amputation. Resting at night sex signiifcantly reduce pain, show the sleep quality improved.Conclusion Hyperbaric oxygen treatment of diabetic foot every period all can obtain satisfactory curative effect.%目的:观测高压氧治疗各期糖尿病足患者间歇性跛行的疗效。方法选取糖尿病足患者26例,无破溃但足趾皮肤暗紫色的0级糖尿病足7例,足部破溃19例,观察步行引起疼痛的时间。结果经过高压氧治疗组,步行引起疼痛的时间明显延长,两组数据比较有统计学意义,P<0.05。踝肱指数(ABI)及局部皮温有所改善。治疗后血糖下降明显。溃疡面愈合11例,剩余8例溃疡面明显缩小,可以避免截肢。夜间静息性疼痛明显减轻,表现为睡眠质量改善。结论高压氧治疗各期糖尿病足均可获得满意疗效。

  20. Familial Periodic Paralyses

    ... two most common types of periodic paralyses are: Hypokalemic periodic paralysis is characterized by a fall in potassium levels ... chronic muscle weakness later in life. Hyperkalemic periodic paralysis is ... than the hypokalemic form. Muscle spasms are common. Is there any ...

  1. Dysmenorrhea: Painful Periods

    ... Management Education & Events Advocacy For Patients About ACOG Dysmenorrhea: Painful Periods Home For Patients Search FAQs Dysmenorrhea: ... Dysmenorrhea: Painful Periods FAQ046, January 2015 PDF Format Dysmenorrhea: Painful Periods Gynecologic Problems What is dysmenorrhea? How ...

  2. Algebraically periodic translation surfaces

    Calta, Kariane; Smillie, John

    2007-01-01

    Algebraically periodic directions on translation surfaces were introduced by Calta in her study of genus two translation surfaces. We say that a translation surface with three or more algebraically periodic directions is an algebraically periodic surface. We show that for an algebraically periodic surface the slopes of the algebraically periodic directions are given by a number field which we call the periodic direction field. We show that translation surfaces with pseudo-Anosov automorphisms...

  3. Treatment of diabetic polyneuropathy with the neurotrophic peptide ORG 2766.

    Valk, G D; Kappelle, A C; Tjon-A-Tsien, A M; Bravenboer, B; Bakker, K; Michels, R P; Groenhout, C M; Bertelsmann, F W

    1996-03-01

    The efficacy of the neurotrophic peptide ORG 2766 in diabetic patients with polyneuropathy was evaluated in a double-blind, placebo-controlled, multicentre trial. One hundred and twenty four patients were randomised in five groups to receive 0.1, 0.4, 2 or 5 mg ORG 2766 or placebo, once daily, administered subcutaneously 52 weeks. Thermal discrimination thresholds (TDT) and vibration perception thresholds (VPT), motor and sensory nerve conduction velocity, Hoffmann reflex, heart rate variation during deep breathing and heart rate response after standing up, neurological examination score and neuropathic symptom score were determined at baseline and after 17, 34 and 52 weeks of treatment. Of the nerve function indices studied, at week 52 the TDTwarmth of the hand in the ORG 2766 0.1, 0.4 and 5 mg groups and the TDTcold of the foot in the ORG 2766 0.1 and 0.4 mg groups significantly improved compared with placebo. Further significant improvement as compared with placebo was observed in the paraesthesia score at week 34 and week 52 in the ORG 2766 2 mg group. Only at week 34 had both the heartbeat variation during deep breathing and the VPT of the foot in the ORG 2766 0.1 mg group improved significantly, compared with placebo. No further statistically significant differences were observed at time for the other measures. No adverse reactions were observed. The only recorded drug-induced side effect was pain at the injection site. Taking all measures of efficacy into account, the statistically significant results observed did not show consistency within each measure. Therefore, it is concluded that ORG 2766, in contrast to earlier reports, is not effective in treating diabetic polyneuropathy. PMID:8936356

  4. Comparison of Buprenorphine Treatment for Opioid Dependence in Three Settings

    Hillhouse, Maureen; Donovick, Roger; Cunningham-Rathner, Jerry; Charuvastra, Charlie; Torrington, Matthew; Esagoff, Asher E.; Ling, Walter

    2011-01-01

    Although use of buprenorphine in the treatment of opioid dependence is expected to continue to increase, little is known about the optimal setting for providing the medical and psychosocial care required with buprenorphine pharmacotherapy. OBJECTIVE This study compared buprenorphine therapy delivered in three distinct treatment settings: an opioid-treatment program (OTP) offering individual counseling; a group counseling program utilizing the manualized Matrix Model (MMM) of cognitive-behavioral treatment; and a private clinic setting mirroring standard medical management for buprenorphine treatment provided specifically at a psychiatrist’s private practice (PCS). METHOD Participants were inducted on buprenorphine and provided with treatment over a 52-week study duration. All participants were scheduled for weekly treatment visits for the first 6 study weeks, and two sites reduced treatment to monthly visits for dispensing of medication and psychosocial counseling. Outcomes include opioid use, participant retention in treatment, and treatment participation. RESULTS Participants presenting for treatment at the sites differed only by race/ethnicity, and opioid use did not differ by site. Retention differed by treatment site, with the number of participants who stayed in the study until the end of 20 weeks significantly associated with treatment site. The mean number of minutes spent in each individual counseling session also differed by site. Although no difference in opioid use by treatment site was found, results document a significant association between opioid use and buprenorphine dose. DISCUSSION These results show some differences by treatment site, although the similarity and relative ease in which the sites were able to recruit participants for treatment with buprenorphine, and minor implementation problems reported suggests the feasibility of treatment with buprenorphine across various treatment settings. CONCLUSION Similar rates of continued opioid use

  5. Naltrexone/bupropion for the treatment of obesity and obesity with Type 2 diabetes.

    Apovian, Caroline M

    2016-03-01

    Contrave(®) is a combination of naltrexone hydrochloride extended release and bupropion hydrochloride extended release for the treatment of obesity, and is used with lifestyle modification. Its safety and efficacy were assessed in four randomized, double-blind, placebo-controlled, 56-week Phase III clinical trials in 4536 adult subjects: COR-1, COR-II, COR-BMOD and COR-DM. All four studies demonstrated statistically significant and clinically meaningful weight loss following up to 52 weeks of treatment with naltrexone/bupropion compared with placebo. The average weight loss from baseline across the four studies was approximately 11-22 lbs (5-9 kg). Results show the efficacy of Contrave for weight loss, as well as significant improvements in cardiometabolic markers. This review focuses on the four studies, their outcomes and the mechanism of action of Contrave. PMID:26679384

  6. 不同时间骨质疏松性椎体压缩骨折的经皮椎体成形治疗☆%Percutaneous vertebroplasty for the treatment of osteoporotic vertebral compression fractures with different fracture periods

    张其亮; 王峻; 林勇

    2013-01-01

      背景:近年来应用经皮椎体成形治疗老年骨质疏松性椎体压缩骨折的技术正在逐步开展,但其治疗不同骨折时间患者的疗效还存在争议。目的:对比经皮椎体成形治疗不同骨折时间骨质疏松性椎体压缩骨折的临床疗效。方法:回顾性分析随访资料完整的行经皮椎体成形治疗的骨质疏松性椎体压缩骨折病例91例(127节椎体)。按照受伤或疼痛发生到手术时间将病例分为3组:伤后3周内组、伤后3周-6个月组、伤后6个月以上组,比较3组经皮椎体成形治疗后疼痛缓解、日常生活能力恢复及椎体高度恢复情况。结果与结论:①3组治疗后疼痛明显缓解,且随着时间的延长疼痛逐渐减轻(P 伤后3周-6个月组>伤后6个月以上组(P 伤后3周-6个月组>伤后6个月以上组(P <0.01)。治疗前及治疗后3d各组椎体后缘高度差异无显著性意义。表明经皮椎体成形治疗对于伤后6个月以上陈旧性骨折的疗效较差。%BACKGROUND: In recent years, the technique of percutaneous vertebroplasty for the treatment of osteoporotic vertebral compression fractures is gradual y developed, but there is a controversy of the clinical effectiveness of percutaneous vertebroplasty for the treatment of osteoporotic vertebral compression fractures with different fracture periods. OBJECTIVE: To compare the effectiveness of percutaneous vertebroplasty for the treatment of osteoporotic vertebral compression fractures with different fracture periods METHODS: A retrospective study was conducted to review 91 cases receiving percutaneous vertebroplasty on 127 vertebral compression fractures. The patients were divided into three groups according to the time from fracture or pain occurrence to surgery: < 3 weeks group, 3 weeks-6 months group, ≥ 6 months group. The visual analogue scale, the Activity of Daily Living Scale and the height of vertebras were recorded and analyzed in the three

  7. Safety and Efficacy of Nucleic Acid Polymers in Monotherapy and Combined with Immunotherapy in Treatment-Naive Bangladeshi Patients with HBeAg+ Chronic Hepatitis B Infection

    Al-Mahtab, Mamun; Bazinet, Michel; Vaillant, Andrew

    2016-01-01

    Previous in vivo studies have suggested that nucleic acid polymers (NAPs) may reduce circulating levels of HBsAg in the blood by blocking its release from infected hepatocytes and that this effect may have clinical benefit. NAP treatment, was evaluated in two clinical studies in patients with HBeAg positive chronic HBV infection. The REP 101 study examined REP 2055 monotherapy in 8 patients and the REP 102 study examined REP 2139-Ca, in monotherapy in 12 patients, 9 of which transitioned to short term combined treatment with pegylated interferon alpha 2a or thymosin alpha 1. In both studies NAP monotherapy was accompanied by 2–7 log reductions of serum HBsAg, 3–9 log reductions in serum HBV DNA and the appearance of serum anti-HBsAg antibodies (10–1712 mIU / ml). Eight of the 9 patients transitioning to combined treatment with immunotherapy (pegylated interferon or thymosin alpha 1) in the REP 102 study experienced HBsAg loss and all 9 patients experienced substantial increases in serum anti-HBsAg antibody titers before withdrawal of therapy. For 52 weeks after removal of REP 2055 therapy, rebound of serum viremia (HBV DNA > 1000 copies / ml, HBsAg > 1IU / ml) was not observed in 3 / 8 patients. Suppression of serum virema was further maintained for 290 and 231 weeks in 2 of these patients. After withdrawal of all therapy in the 9 patients that transitioned to combination therapy in the REP 102 study, 8 patients achieved HBV DNA Viral rebound occurred over a period of 12 to 123 weeks in 7 patients but was still absent in two patients at 135 and 137 weeks of follow-up. Administration tolerability issues observed with REP 2055 were rare with REP 2139-Ca but REP 2139-Ca therapy was accompanied by hair loss, dysphagia and dysgeusia which were considered related to heavy metal exposure endemic at the trial site. These preliminary studies suggest that NAP can elicit important antiviral responses during treatment which may improve the effect of immunotherapy. NAPs

  8. Rest versus exercise as treatment for patients with low back pain and Modic changes. A randomised controlled clinical trial

    Jensen, Rikke Krüger; Leboeuf-Yde, Charlotte; Wedderkopp, Niels;

    2012-01-01

    pathology, Modic changes might be a diagnostic subgroup that does not benefit from exercise. The objective of this study was to compare the current state-of-the art treatment approach (exercise and staying active) with a new approach (load reduction and daily rest) for people with Modic changes using a......ABSTRACT: BACKGROUND: Clinical experience suggests that many patients with Modic changes have relatively severe and persistent low back pain (LBP), which typically appears to be resistant to treatment. Exercise therapy is the recommended treatment for chronic LBP, however due to their underlying...... or exercise therapy once a week for 10 weeks. Follow-up was at 10 weeks after recruitment and 52 weeks after intervention and the clinical outcome measures were pain, disability, general health and global assessment, supplemented by weekly information on low back problems and sick leave measured by...

  9. Preliminary report on use of CO2 laser treatment of traumatic pulpal exposure in dogs: a clinical study

    Wilder-Smith, Petra B. B.; Peavy, George M.; Nielsen, David; Arrastia-Jitosho, Anna-Marie A.; Berns, Michael W.

    1997-05-01

    The objective of this study was to evaluate carbon-dioxide laser surgical treatment of pulpal exposures in canine patients. Seventeen permanent teeth with exposures of less than or equal to 48 h were randomly allocated to receive either (1) localized laser pulp surgery to remove all compromised soft tissues or (2) localized pulp surgery using a large round sterile bur under sterile saline irrigation. Single laser pulses were used at 0.01 s pulse duration, 1.0 s pulse interval, a spot size of 0.004 cm2 and an energy density of 276 J/cm2. Exposures were dressed with CaOH and glass ionomer. Clinical and radiographic evaluations were performed by one blinded clinician 4, 12, 24 and 52 weeks after treatment using standard scales of 0-(-1). Fifteen/seventeen laser-treated teeth assessed over greater than or equal to 1 year post-treatment remained clinically and radiographically healthy.

  10. Periodic trajectories in TDHF

    A condition for the existence of a periodic TDHF trajectory of period T is derived. It takes a from very similar to the static H.F. equation and shows that associated to a periodic trajectory there is a static single particle hamiltonian which is a complicated functional of the time dependent density matrix. An explicit expansion for this functional is derived. It is shown that many properties of the static H.F. rest point are shared by periodic solutions. (Author)

  11. Potassium-Related Periodic Paralysis

    A Lesani; MH Moradi Nejad

    1995-01-01

    Potassium-related periodic paralysis may be associated with hypo, normo, or hyperkalemic disturbance of the Potassium level. Clinical features, laboratory findings and ECG as well as EMG changes are different in the 3 types of the disease. The treatment demands correction of the Potassium level of the blood serum. The disease is normally transferred as an autosomal dominant trait. In this article we present a 9-year old girl who suffered from hypokalemic paralysis since she was 4 years old.

  12. The Periodic Pyramid

    Hennigan, Jennifer N.; Grubbs, W. Tandy

    2013-01-01

    The chemical elements present in the modern periodic table are arranged in terms of atomic numbers and chemical periodicity. Periodicity arises from quantum mechanical limitations on how many electrons can occupy various shells and subshells of an atom. The shell model of the atom predicts that a maximum of 2, 8, 18, and 32 electrons can occupy…

  13. Painful menstrual periods

    ... you sexually active? Do you use birth control? What type? When was your last menstrual period? Was the flow of your last menstrual period a normal amount for you? Do your periods tend ... with menstruation? What have you done to try to relieve the ...

  14. 40 CFR 264.96 - Compliance period.

    2010-07-01

    ....96 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Releases From Solid Waste Management Units § 264.96 Compliance period. (a) The Regional Administrator...

  15. The epidemic of smallpox in Guangdong Province and its prevention and treatment in the Republican period%民国时期广东的天花流行与防治

    陈丽楠; 刘玲娣

    2014-01-01

    民国时期,广东几乎每年都有天花疫情发生.为了应对传染病,广东省建立了卫生行政及传染病防治机构,并自制牛痘疫苗;相关机构按周、月、年对疫情进行统计,并定期上报,以了解疫情进展.同时,还成立了传染病医院收容天花患者.港口检疫则将天花列为重点检查对象.为了推广牛痘接种,政府与社会合作,组织大规模的“种痘运动”,以儿童、学生和年轻人作为主要接种对象,并借助媒体积极宣传天花防治知识.%During the Republican period,the smallpox broke out in high frequency almost annually in Guangdong.In response to infectious diseases,the Guangdong government established the Health Administration and institutions for infectious disease's prevention and treatment,and prepared smallpox vaccine by themselves.In order to grasp the situation of the epidenmic,related institutions collected epidemic data weekly,monthly,and annually with the statistics reported regularly.Meanwhile,infectious diseasc hospital was established for smallpox patients.Harbor quarantine put smallpox as a key target of inspection.With the joint effort of the government and social organizations,massive "vaccination campaigns" was organized to promote vaccination,in which children,students and young people were the main subjects for inoculations.Prevention knowledge and anti-epidemic concept towards smallpox have been actively publicized and improved by media.

  16. Periodicity of chaotic solutions

    Berezowski, Marek

    2016-01-01

    The scope of the paper is the analysis of the impact of flow reversal on the dynamics of cascades of reactors. Periodic and chaotic oscillations occur in the analyzed system. There is a dependence between the oscillation period of the state variable of the system without flow reversal and the recurrence period of windows of chaos in the steady-state diagram of the system with flow reversal.

  17. Crystallography without periodicity

    A condition of physics stability, applied to materials with sharp Bragg peaks, leads to rules for a unified approach to their classification that make no use of periodicity, applying equally well to either periodic or quasiperiodic materials. Three-dimensional geometric intuition is the primary analytical tool for extracting the classification from the rules. Recognizing that periodicity is not required to formulate crystallography removes the need for an algebraic formalization of that intuition in a higher dimensional superspace, where the material can be embedded in a periodic supercrystal. Selected examples illustrate the simplicity of the resulting description of ordinary crystals, quasicrystals, modulated crystals, intergrowth crystals, or modulated quasicrystals. (Author) 9 refs

  18. 温度变化和1-MCP处理对青椒贮藏品质的影响%Effects of Temperature Variation and 1-MCP Treatment on Quality of Green Pepper during Storage Period

    侯田莹; 王福东; 寇文丽; 王博华; 郑淑芳

    2012-01-01

    以丰田新秀青椒为试材,模拟贮运过程中温度的变化,研究其对青椒品质的影响以及1-MCP处理在此过程中的保鲜效果.结果表明,贮运环境温度的变化容易导致青椒果实呼吸作用增强,失重率增加,可溶性固形物、可滴定酸、VC等营养成分消耗过快,硬度下降,造成衰败和腐烂;1-MCP处理可以显著抑制青椒由于温度变化而产生的代谢增强,从而较好地保持其可溶性固形物、可滴定酸、VC等营养成分,减少质量损失和腐败的发生,延缓果实的成熟和转红.10℃恒温结合1-MCP处理贮藏35d的青椒商品率可达90%以上;模拟青椒贮运条件,采用1μL/L浓度的1-MCP熏蒸24h,在10℃贮藏6d后,取出,盖上保温被在室温25℃条件下放置24h,再重新放入10℃冷库中贮藏28d时,青椒果实的商品率可达70%以上.%The green peppers of cultivar ' Fengtianxinxiu' were used as material to investigate the effect of temperature variation and dealing with 1 -MCP on quality of green pepper during storage period. The results showed that, temperature variation promoted the increase of respiration rate, weight loss rate, the consumption of some nutrition, such as soluble solids, titratable acidity, VC and so on, and the reduce of hardness, and might cause decay. However, 1-MCP treatment could significantly inhibit the increase of metabolism resulted from temperature, variation, and the nutrition was well maintained, reduced weight loss and delay, thereby, the maturity process from green peppers to red ones were delayed. The commodity rate of green pepper treated with 1-MCP at 10 ℃ storage temperature for 35 d was above 90%. The green peppers dealing with 1 |xL/L concentration of 1-MCP for 24 h, were taken out from the cold store after 6 days storage at 10 ℃ and then coated with polyurethane insulation for 24 h at room temperature (25 ℃), afterwards given back into the 10 ℃ cold store once again for 28 days storage , after

  19. Second Period Access Report

    Maisondieu, Christophe; Giebhardt, Jochen; Tetu, Amelie; Johnstone, Cameron; Healy, Mark

    The work described in this publication has received support from the European Community - Research Infrastructure Action under the FP7 “Capacities” Specific Programme through grant agreement number 262552, MaRINET. Project Periodic Report. 2nd Period: October 2012 – March 2014 inclusive....

  20. Historically defined autobiographical periods

    Brown, Norman R.; Hansen, Tia G. B.; Lee, Peter J.;

    2012-01-01

    The chapter reviews a research programme that has demonstrated the existence of historically defined autobiographical periods and identified the conditions that bring them about. Data from four samples of World War II-generation adults show that historically defined autobiographical periods endure...

  1. The Living Periodic Table

    Nahlik, Mary Schrodt

    2005-01-01

    To help make the abstract world of chemistry more concrete eighth-grade students, the author has them create a living periodic table that can be displayed in the classroom or hallway. This display includes information about the elements arranged in the traditional periodic table format, but also includes visual real-world representations of the…

  2. On some periodicity effects

    Sorokin, Sergey V.

    2015-01-01

    . In each case, special attention is paid to eigenfrequencies and eigenmodes of a single periodicity cell with appropriate boundary conditions. The influence of the amount of periodicity cells in a finite compound structure on its eigenfrequency spectrum is analyzed. Several features common for the......The talk is concerned with the modelling of wave propagation in and vibration of periodic elastic structures. Although analysis of wave-guide properties of infinite periodic structures is a well establish research subject, some issues have not yet been fully addressed in the literature. The aim of...... the talk is to illustrate these issues in simple examples and to discuss possible applications and generalisations. First, the eigenfrequency spectra of finite periodic structures are compared with the location of stop-bands for their infinite counterparts for a hierarchy of four mathematical models...

  3. Setting the Periodic Table.

    Saturnelli, Annette

    1985-01-01

    Examines problems resulting from different forms of the periodic table, indicating that New York State schools use a form reflecting the International Union of Pure and Applied Chemistry's 1984 recommendations. Other formats used and reasons for standardization are discussed. (DH)

  4. The Periodic Table CD.

    Banks, Alton J.; Holmes, Jon L.

    1995-01-01

    Describes the characteristics of the digitized version of The Periodic Table Videodisc. Provides details about the organization of information and access to the data via Macintosh and Windows computers. (DDR)

  5. Establishing contract periods

    The lead time for executing the Adjustable Fixed-Commitment (AFC) contract and exceptions which may be considered are discussed. The initial delivery period is also discussed. Delays, deferrals, and schedule adjustment charges are finally considered

  6. Painful periods (dysmenorrhea) (image)

    Primary dysmenorrhea is a normal cramping of the lower abdomen caused by hormone-induced uterine contractions before the period. Secondary dysmenorrhea may be caused by abnormal conditions such as ...

  7. Periodic solutions of periodically harvested lotka-volterra systems

    Hausrath, Alan R.; Manasevich, Raul F.

    2012-01-01

    We study a Lotka-Volterra system with periodic harvesting, find sufficient conditions for the existence of periodic solutions with the same period, and, under certain conditions, count the number of such periodic solutions.

  8. Combination treatment with methotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis

    Hetland, Merete Lund; Stengaard-Pedersen, Kristian; Junker, Peter;

    2006-01-01

    OBJECTIVE: To investigate whether disease control can be achieved in early active rheumatoid arthritis (RA) by treatment with methotrexate and intraarticular betamethasone, and whether the addition of cyclosporine to the regimen has any additional effect. METHODS: Patients (n = 160) were randomized...... to receive methotrexate 7.5 mg/week plus cyclosporine 2.5 mg/kg of body weight/day (combination therapy) or methotrexate plus placebo-cyclosporine (monotherapy). At weeks 0, 2, 4, 6, and 8 and every 4 weeks thereafter, betamethasone was injected into swollen joints (maximum 4 joints or 4 ml per visit......). Beginning at week 8, if synovitis was present, the methotrexate dosage was increased stepwise up to 20 mg/week, with a subsequent stepwise increase in the cyclosporine or placebo-cyclosporine dosage up to 4 mg/kg. RESULTS: At 52 weeks, 20% improvement according to the American College of Rheumatology...

  9. Combination treatment with metrotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis

    Hetland, Merete; Stengaard-Pedersen, Kristian; Junker, Peter;

    2006-01-01

    OBJECTIVE: To investigate whether disease control can be achieved in early active rheumatoid arthritis (RA) by treatment with methotrexate and intraarticular betamethasone, and whether the addition of cyclosporine to the regimen has any additional effect. METHODS: Patients (n = 160) were randomized...... to receive methotrexate 7.5 mg/week plus cyclosporine 2.5 mg/kg of body weight/day (combination therapy) or methotrexate plus placebo-cyclosporine (monotherapy). At weeks 0, 2, 4, 6, and 8 and every 4 weeks thereafter, betamethasone was injected into swollen joints (maximum 4 joints or 4 ml per visit......). Beginning at week 8, if synovitis was present, the methotrexate dosage was increased stepwise up to 20 mg/week, with a subsequent stepwise increase in the cyclosporine or placebo-cyclosporine dosage up to 4 mg/kg. RESULTS: At 52 weeks, 20% improvement according to the American College of Rheumatology...

  10. Periodic table of elements

    Following a recommendation by the International Union for Pure and Applied Chemistry (IUPAC), the groups of the periodic table shall be numbered from 1 to 18, instead of I to VIII as before. The recommendations has been approved of by the Committee on Nomenclature of the American Chemical Society. The new system abandons the distinction between main groups (a) and auxiliary groups (b), which in the past frequently has been the reason for misunderstandings between European and American chemists, due to different handling. The publishing house VCH Verlagsgesellschaft recently produced a new periodic table that shows the old and the new numbering system together at a glance, so that chemists will have time to get familiar with the new system. In addition the new periodic table represents an extensive data compilation arranged by elements. The front page lists the chemical properties of elements, the back page their physical properties. (orig./EF)

  11. Periodic safety analyses

    The IAEA Safety Guide 50-SG-S8 devoted to 'Safety Aspects of Foundations of Nuclear Power Plants' indicates that operator of a NPP should establish a program for inspection of safe operation during construction, start-up and service life of the plant for obtaining data needed for estimating the life time of structures and components. At the same time the program should ensure that the safety margins are appropriate. Periodic safety analysis are an important part of the safety inspection program. Periodic safety reports is a method for testing the whole system or a part of the safety system following the precise criteria. Periodic safety analyses are not meant for qualification of the plant components. Separate analyses are devoted to: start-up, qualification of components and materials, and aging. All these analyses are described in this presentation. The last chapter describes the experience obtained for PWR-900 and PWR-1300 units from 1986-1989

  12. Periodic Chandrasekhar recursions

    Aknouche, Abdelhakim; Hamdi, Fayçal

    2007-01-01

    This paper extends the Chandrasekhar-type recursions due to Morf, Sidhu, and Kailath "Some new algorithms for recursive estimation in constant, linear, discrete-time systems, IEEE Trans. Autom. Control 19 (1974) 315-323" to the case of periodic time-varying state-space models. We show that the S-lagged increments of the one-step prediction error covariance satisfy certain recursions from which we derive some algorithms for linear least squares estimation for periodic state-space models. The p...

  13. Periodically kicked turbulence

    Lohse

    2000-10-01

    Periodically kicked turbulence is theoretically analyzed within a mean-field theory. For large enough kicking strength A and kicking frequency f the Reynolds number grows exponentially and then runs into some saturation. The saturation level Re(sat) can be calculated analytically; different regimes can be observed. For large enough Re we find Re(sat) approximately Af, but intermittency can modify this scaling law. We suggest an experimental realization of periodically kicked turbulence to study the different regimes we theoretically predict and thus to better understand the effect of forcing on fully developed turbulence. PMID:11089041

  14. Complications of the surgical treatment early and tardy of supracondylar fractures of the humerus in children: a retrospective study of 111 patients treated at the Hospital Nacional de Ninos Carlos Saenz Herrera in the period January 2010 to January 2011

    Supracondylar fractures of the humerus up much of the emergency consultation of any pediatric orthopedic service, of them, Gartland III fractures are usually treated by closed reduction and percutaneous fixation with nails smooth. Often treatment has been delayed by factors such as the unavailability of an orthopedic specialist or local anesthesia or an operating room. At other times, the patient has come belatedly to consult. This retrospective study has analyzed whether a delay greater than 12 hours in the surgical treatment of supracondylar fractures of the humerus in children is associated with an increased risk of perioperative complications. Of 111 children who have been treated surgical in national children's hospital, underwent 59 surgeries before 12 hours from the trauma and 52 underwent surgery after 12 hours of trauma. The groups have developed without significant differences in terms of iatrogenic neurological injury, tract infection of the nails, vascular complications and compartment syndrome. Surgical time and hospital stay neither have had differences. In 2 cases of the tardy treatment group has been necessary to perform a opened reduction. As for the bad union, 9 cases (8%) have been of elbow varus radiological and clinical, of these 5 cases (4.5%) have occurred in the tardy treatment group and 4 cases (3,5) in the group early treatment. Findings of similar studies are confirmed in which the rate of perioperative complications is significantly unchanged if the surgical treatment is carried out before 12 hours or after 12 hours after the trauma. (author)

  15. A Modern Periodic Table.

    Herrenden-Harker, B. D.

    1997-01-01

    Presents a modern Periodic Table based on the electron distribution in the outermost shell and the order of filling of the sublevels within the shells. Enables a student to read off directly the electronic configuration of the element and the order in which filling occurs. (JRH)

  16. Periodic Table of Students.

    Johnson, Mike

    1998-01-01

    Presents an exercise in which an eighth-grade science teacher decorated the classroom with a periodic table of students. Student photographs were arranged according to similarities into vertical columns. Students were each assigned an atomic number according to their placement in the table. The table is then used to teach students about…

  17. Higher charge periodic monopoles

    Maldonado, Rafael

    2013-01-01

    We consider singly periodic solutions to the SU(2) Bogomolny equations and use the Nahm transform to generate a class of monopoles of charge k>2, thereby extending known results for lower charge chains. Some simple scattering processes are presented and a comparison made with geodesic motion of monopoles in $\\mathbb{R}^3$.

  18. Ayurveda during Abbasid's period.

    Husain, S A; Subhaktha, P K

    2000-01-01

    This is a historical paper which deals with a brief account of Abbasid's period. In this article the existence of Ayurveda in Arab countries, arrival of Ayurvedic physicians to Baghdad, their eminence, authenticity and literary additions in medical field has been studied and presented. PMID:12578013

  19. Periodic paralysis complicating malaria.

    Senanayake, N; Wimalawansa, S J

    1981-01-01

    Episodic muscular weakness, commonly associated with alterations of serum potassium, is the cardinal feature of periodic paralysis. The combination of transient hyperkalaemia and rigors occurring during febrile episodes of malaria is suggested as the underlying cause which precipitated the muscular paralysis. Three patients with malaria who developed a similar paralysis during the paroxysms of fever are described to illustrate this.

  20. Scheduling: Seven Period Day

    Williamson, Ronald

    2010-01-01

    Driven by stable or declining financial resources many school districts are considering the costs and benefits of a seven-period day. While there is limited evidence that any particular scheduling model has a greater impact on student learning than any other, it is clear that the school schedule is a tool that can significantly impact teacher…

  1. Almost periodic Schroedinger operators

    These lectures are devoted to recent developments in the theory of almost-periodic Schroedinger Operators. We specially describe the algebraic point of view, with applications to gap-labelling theorems. Particular models are also presented which exhibit various spectral properties. (orig.)

  2. SU-E-J-17: Intra-Fractional Prostate Movement Correction During Treatment Delivery Period for Prostate Cancer Using the Intra-Fractional Orthogonal KV-MV Image Pairs

    Zhang, J; Azawi, S; Cho-Lim, J; Wei, R; Williams, R; Frank, E [VA Long Beach Healthcare System, Long Beach, CA (United States)

    2015-06-15

    Purpose: To evaluate the intra-fractional prostate movement range during the beam delivery and implement new IGRT method to correct the prostate movement during the hypofractionated prostate treatment delivery. Methods: To evaluate the prostate internal motion range during the beam delivery, 11 conventional treatments were utilized. Two-arc RapidArc plans were used for the treatment delivery. Orthogonal KV imaging is performed in the middle of the treatment to correct intra-fractional prostate movement. However, it takes gantry-mounted on-board imaging system relative long time to finish the orthogonal KV imaging because of gantry rotation. To avoid gantry movement and accelerate the IGRT processing time, orthogonal KV-MV image pair is tested using the OBI daily QA Cube phantom. Results: The average prostate movement between two orthogonal KV image pairs was 0.38cm (0.20cm ∼ 0.85cm). And the interval time between them was 6.71 min (4.64min ∼ 9.22 min). 2-arc beam delivery time is within 3 minutes for conventional RapidArc treatment delivery. Hypofractionated treatment or SBRT need 4 partial arc and possible non-coplanar technology, which need much longer beam delivery time. Therefore prostate movement might be larger. New orthogonal KV-MV image pair is a new method to correct the prostate movement in the middle of the beam delivery if real time tracking method is not available. Orthogonal KV-MV image pair doesn’t need gantry rotation. Images were acquired quickly which minimized possible new prostate movement. Therefore orthogonal KV-MV image pair is feasible for IGRT. Conclusion: Hypofractionated prostate treatment with less PTV margin always needs longer beam delivery time. Therefore prostate movement correction during the treatment delivery is critical. Orthogonal KV-MV imaging pair is efficient and accurate to correct the prostate movement during treatment beam delivery. Due to limited fraction number and high dose per fraction, the MV imaging dose is

  3. SU-E-J-17: Intra-Fractional Prostate Movement Correction During Treatment Delivery Period for Prostate Cancer Using the Intra-Fractional Orthogonal KV-MV Image Pairs

    Purpose: To evaluate the intra-fractional prostate movement range during the beam delivery and implement new IGRT method to correct the prostate movement during the hypofractionated prostate treatment delivery. Methods: To evaluate the prostate internal motion range during the beam delivery, 11 conventional treatments were utilized. Two-arc RapidArc plans were used for the treatment delivery. Orthogonal KV imaging is performed in the middle of the treatment to correct intra-fractional prostate movement. However, it takes gantry-mounted on-board imaging system relative long time to finish the orthogonal KV imaging because of gantry rotation. To avoid gantry movement and accelerate the IGRT processing time, orthogonal KV-MV image pair is tested using the OBI daily QA Cube phantom. Results: The average prostate movement between two orthogonal KV image pairs was 0.38cm (0.20cm ∼ 0.85cm). And the interval time between them was 6.71 min (4.64min ∼ 9.22 min). 2-arc beam delivery time is within 3 minutes for conventional RapidArc treatment delivery. Hypofractionated treatment or SBRT need 4 partial arc and possible non-coplanar technology, which need much longer beam delivery time. Therefore prostate movement might be larger. New orthogonal KV-MV image pair is a new method to correct the prostate movement in the middle of the beam delivery if real time tracking method is not available. Orthogonal KV-MV image pair doesn’t need gantry rotation. Images were acquired quickly which minimized possible new prostate movement. Therefore orthogonal KV-MV image pair is feasible for IGRT. Conclusion: Hypofractionated prostate treatment with less PTV margin always needs longer beam delivery time. Therefore prostate movement correction during the treatment delivery is critical. Orthogonal KV-MV imaging pair is efficient and accurate to correct the prostate movement during treatment beam delivery. Due to limited fraction number and high dose per fraction, the MV imaging dose is

  4. Cells anticipate periodic events

    Nakagaki, Toshiyuki

    2009-03-01

    We show that an amoeboid organism can anticipate the timing of periodic events. The plasmodium of the true slime mold Physarum polycephalum moves rapidly under favourable conditions, but stops moving when transferred to less-favourable conditions. Plasmodia exposed to unfavourable conditions, presented in three consecutive pulses at constant intervals, reduced their locomotive speed in response to each episode. When subsequently subjected to favourable conditions, the plasmodia spontaneously reduced their locomotive speed at the time point when the next unfavourable episode would have occurred. This implied anticipation of impending environmental change. After this behaviour had been evoked several times, the locomotion of the plasmodia returned to normal; however, the anticipatory response could subsequently be induced by a single unfavourable pulse, implying recall of the memorized periodicity. We explored the mechanisms underlying these behaviours from a dynamical systems perspective. Our results hint at the cellular origins of primitive intelligence and imply that simple dynamics might be sufficient to explain its emergence.

  5. Notes on Periodic Solitons

    Bakas, Ioannis

    2002-01-01

    We consider static solutions of the sine-Gordon theory defined on a cylinder, which can be either periodic or quasi-periodic in space. They are described by the different modes of a simple pendulum moving in an inverted effective potential and correspond to its libration or rotation. We review the decomposition of the solutions into an oscillatory sum of alternating kinks and anti-kinks or into a monotonic train of kinks, respectively, using properties of elliptic functions. The two sectors are naturally related to each other by a modular transformation, whereas the underlying spectral curve of the model can be used to express the energy of the static configurations in terms of contour integrals \\`a la Seiberg-Witten in either case. The stability properties are also examined by means of supersymmetric quantum mechanics, where we find that the unstable configurations are associated to singular superpotentials, thus allowing for negative modes in the spectrum of small fluctuations.

  6. Hypokalemic periodic paralysis

    Abbas, Haider; Kothari, Nikhil; Bogra, Jaishri

    2012-01-01

    Hypokalemic periodic paralysis is a rare genetic disorder characterized by recurrent attacks of skeletal muscle weakness with associated hypokalemia which is precipitated by stress, cold, carbohydrate load, infection, glucose infusion, hypothermia, metabolic alkalosis, anesthesia, and steroids. We encountered one such incidence of prolonged recovery after general anesthesia, which on further evaluation revealed a case of hypokalemic paralysis. The key to successful management of such a patien...

  7. Scattering of periodic solitons

    Cova, R.J. [Carleton University, School of Mathematics and Statistics, 1125 Colonel by Drive, Ottawa, Ontario K1S 5B6 (Canada); Zakrzewski, W.J. [University of Durham, Dept. of Mathematical Sciences, Durham DH1 3LE (United Kingdom)]. e-mail: rcova@math.carleton.ca

    2004-07-01

    Through numerical simulations we study N-soliton scattering (N = 3, 4) in the (2 + 1)-dimensional CP{sup 1} model with periodic boundary conditions. Solitons colliding from symmetrical configurations scatter at {pi}/ N, as observed in the usual model with standard boundary conditions. When the initial configurations are not symmetric the angles differ from {pi}/ N. We describe our observed patterns based on a properly formulated geodesic approximation. (Author) 11 refs., 10 figs.

  8. 不同时期脑卒中后抑郁的心理分析治疗及护理对策%Psychoanalysis treatment on post-stroke depression in different periods and the nursing strategies

    邓华; 段勇

    2013-01-01

    Objective To study the psychoanalysis treatment on post-stroke depression in different periodsand the nursing strategies. Methods36 cases of patients with post-stroke depression were treated and nursed with the method of psychoanalysis, and prescribed with appropriate antidepressant treatment. To compare the changes of pre and post treatment with the scores of Hamilton Depression Rating Scale (HAMD). Results23 cases were cured (63.89%), 11 cases were getting better (30.56%), and 2 cases were ineffective (5.55%). The total effective rate is 94.44%. ConclusionThe method of proper psychoanalysis treatment and nursing, accompanying with appropriate antidepressant treatment , can notably relieve the depressive symptoms and improve the patients’ activities of daily living.%目的:探讨不同时期脑卒中后抑郁的心理分析治疗及护理对策方法。方法对36例脑卒中后抑郁的病人进行心理分析治疗和护理,并且适当给予抗抑郁药物治疗,治疗前后用汉密尔顿抑郁量表(HAMD)评分对比变化。结果治愈23例(63.89%),好转11例(30.56%),无效2例(5.55%),总有效率94.44%。结论对脑卒中后抑郁的病人进行正确的心理分析治疗及护理,并适当抗抑郁药物治疗,能明显改善患者的抑郁症状,提高患者日常生活活动能力。

  9. Tolvaptan and its potential in the treatment of hyponatremia

    Y Howard Lien

    2008-10-01

    Full Text Available Megan B Dixon, Y Howard LienDepartment of Medicine, University of Arizona, Arizona Kidney Disease and Hypertension Center, Tucson, Arizona, USAAbstract: Tolvaptan is a selective arginine vasopressin (AVP V2 receptor blocker used to induce free water diuresis in the treatment of euvolemic or hypervolemic hyponatremia. Currently the orally active medication is in the final stages prior to approval by the FDA for outpatient therapy. It appears to be safe and effective at promoting aquaresis and raising serum sodium levels in both short- and long-term studies. Tolvaptan is also effective for treatment of congestive heart failure (CHF exacerbation, but whether there are long standing beneficial effects on CHF is still controversial. Prolonged use of tolvaptan leads to increased endogenous levels of AVP and perhaps over-stimulation of V1A receptors. Theoretically this activation could lead to increased afterload and cardiac myocyte fibrosis, causing progression of CHF. However, after 52 weeks of tolvaptan therapy there was no worsening of left ventricular dilatation. In addition, tolvaptan is metabolized by the CYP3A4 system; thus physicians should be aware of the potential for increased interactions with other medications. Tolvaptan is a breakthrough in the therapy of hyponatremia as it directly combats elevated AVP levels associated with the syndrome of inappropriate secretion of antidiuretic hormone, congestive heart failure, and cirrhosis of the liver.Keywords: hyponatremia, arginine vasopressin, vasopressin receptors, syndrome of inappropriate antidiuretic hormone, congestive heart failure, liver cirrhosis

  10. Polysheroidal periodic functions

    Separation of variables in the Helmholtz N-dimensional (N≥4) equation in polyspheroidal coordinate systems leads to the necessity of solving equations going over into equations for polyspheroidal periodic functions used for solving the two-centre problem in quantum mechanics, the three-body problem with Coulomb interaction, etc. For these functions the expansions are derived in terms of the Jacobi polynomials and Bessel functions. Their basic properties, asymptotics are considered. The algorithm of their computer calculations is developed. The results of numerical calculations are given

  11. Periodic Mesoporous Organosilica Nanorice

    Mohanty Paritosh

    2008-01-01

    Full Text Available Abstract A periodic mesoporous organosilica (PMO with nanorice morphology was successfully synthesized by a template assisted sol–gel method using a chain-type precursor. The PMO is composed of D and T sites in the ratio 1:2. The obtained mesoporous nanorice has a surface area of 753 m2 g−1, one-dimensional channels, and a narrow pore size distribution centered at 4.3 nm. The nanorice particles have a length of ca. 600 nm and width of ca. 200 nm.

  12. Scattering of periodic solitons

    Cova, R J

    2003-01-01

    With the help of numerical simulations we study N-soliton scattering (N=3,4) in the (2+1)-dimensional CP^1 model with periodic boundary conditions. When the solitons are scattered from symmetrical configurations the scattering angles observed agree with the earlier \\pi/N predictions based on the model on R_2 with standard boundary conditions. When the boundary conditions are not symmetric the angles are different from \\pi/N. We present an explanation of our observed patterns based on a properly formulated geodesic approximation.

  13. RESULTS OF TREATMENT OF ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: DATA OF A RETROSPECTIVE, SINGLE-CENTER STUDY (IN-HOSPITAL PERIOD

    D. B. Nemick

    2015-12-01

    Full Text Available Myocardial infarction significantly contributes to mortality rates in patients with chronic obstructive pulmonary disease (COPD. The influence of COPD on the course of acute ST-segment elevation myocardial infarction (STEMI is controversial.Aim. To evaluate characteristics of coronary artery lesions and cardiovascular complications in STEMI patients with and without COPD depending on a reperfusion treatment method during in-hospital stay.Material and methods. A total of 1112 cases of STEMI treatment within the first 6 hours of the symptoms onset were analyzed. All of these patients have undergone reperfusion treatment: primary percutaneous coronary intervention (PPCI or pharmacoinvasive strategy (PIS methods. All the patients were divided into two groups: patients without COPD (952 persons; 83.2% and those with COPD (160 patients; 16.8%. COPD impact on in-hospital course of STEMI was assessed.Results. The presence of COPD had no influence on STEMI in-hospital mortality. Mortality rates in patients with COPD (12 subjects; 7.5% and without COPD (83 subjects; 8.7% did not differ significantly (p=0.2. The study has demonstrated the significant influence of COPD on the patients’ baseline characteristics and treatment results, which can have an impact on long-term prognosis. According to our data COPD presence was associated with more severe coronary artery lesions in both PPCI and PIS subgroups (p<0.001. This has determined more frequent transmural myocardial damage in STEMI patients with COPD regardless of reperfusion strategy and time factor (79% in patients with COPD and 50% in those without one, p<0.001. The incidence of hemorrhagic complications also didn’t depend on COPD presence and remained low in all groups.Conclusion. At COPD presence STEMI was associated with more severe coronary artery lesions and increased frequency of transmural myocardial damage and residual stenosis after thrombolytic therapy. COPD did not lead to the

  14. 中老年慢性骨病患者围手术期心理治疗的应用进展%The application and progress of psychological treatment for elderly patients with chronic osteopathia in perioperative period

    何明; 仲霄鹏; 朱锦宇; 朱庆生

    2012-01-01

    The operation can have significant impact on patients' mental states. Patients with degenerative bone and joint diseases tend to exhibit symptoms such as anxiety, depression, fear, insomnia and so on before the operation. At the same time, patients' personality traits may also cause mental problems that affect preoperative preparation and postoperative recovery. Previous literature has failed to provide consistent findings regarding this issue, which may be due to the differences in terms of the specific sampling, measures, and patients. Depression and anxiety can be influenced by the type of bone disease, social support, level of education, and prior surgical treatment. In order to understand patients' mental states, we need to apply measures derived from psychology, which complies with the majority of current studies on this topic. Other scholars also examined the mechanisms through which psychological problems developed. This study reviewed previous literature applying psychology to the surgical treatment of bone diseases. We discussed methods that may relieve patients' anxiety and depression, including medical and non-medical treatment. We found that medical treatment and non-medical treatment can be applied simultaneously, which can lead to better postoperative rehabilitation and recovery.%@@ 手术作为一种应激事件严重地影响着患者的精神状态.长期饱受骨病(如髋、膝退行性骨关节病或脊柱疾病)的中老年患者在面临手术时会出现不同程度的抑郁、焦虑、恐惧、失眠等症状.同时患者的人格特征以及慢性疾病对患者心理的影响,使得患者术前的心理问题更为突出,进而影响到术前准备和术后康复.本文就心理学在骨病外科治疗中的研究和应用做一综述.

  15. [THE ROLE OF MOTHER'S MILK AND BREAST FEEDING. MEDICAL PROBLEMS DURING THE LACTATION PERIOD LACTOBACILUS FERMENTUM--A NEW APPROACH TOWARDS THE PREVENTION AND THE TREATMENT OF ACUTE AND SUBACUTE MASTITIS].

    Popova, B; Mitev, D; Nikolov, A

    2016-01-01

    Breast feeding provides a lot of short and long-term benefits for the mother and the baby. It prevents the baby of gastrointestinal, urinary and respiratory infections, atopical conditions and assures long-term protection of cardiovascular and metabolic diseases. The breast feeding decreases the risk for the mother of ovary and breast carcinoma and creates a positive emotional bond between the mother and the baby Mother's milk is a species specific; its content is relatively stable regardless of mother's age race, way and place of living. Mother's milk is not sterile. There is a 10 year international trial held in Spanish and Finnish universities. It has identified and count all microorganisms in mother's milk (more than 700) and proved that their content and quantity varies according the age of the baby. Mother's milk is a source of lactobacillus for baby's intestines and most of them have probiotic potential. Lactobacillus fermentum Lc40 (hereditum) is isolated from mother's milk. It has a good viability in gastrointestinal system, high level of adhesion to intestinal epithelium cells, produces glutation--strong antioxidant, good antibacterial activity to entero-pathogens and potential of increasing the immunologic response. Clinical trials reveal that Lactobacillus fermentum plays important role to microflora balance of mother's milk in mastitis during lactation. Many trials estimating the efficiency of lactobacillus fermentum in prevention and treatment of acute and subacute mastitis have been carried out. The results of them open a new door in front of us in the treatment of these conditions--treatment with probiotics instead of antibiotics. PMID:27514147

  16. Varenicline in prevention of relapse to smoking: effect of quit pattern on response to extended treatment

    Hajek, Peter; Tønnesen, Philip; Arteaga, Carmen; Russ, Cristina; Tonstad, Serena

    2009-01-01

    achieve abstinence only later in the original course of treatment are more likely to benefit from having the course extended. METHODS: A total of 1208 patients abstinent for at least the last week of 12 weeks' treatment with varenicline were randomized to 3 months continued varenicline or placebo. Overall...... characteristics. RESULTS: With increasing delay in initial quitting, 12-month success rates declined. Participants who had their last cigarette at week 11 of open-label treatment had quit rates at 52 weeks of 5.7% compared with 54.9% in those who last smoked in week 1 [odds ratio (OR) 20.3 (6.3, 65.9); P < 0.......0001]. Patients who failed to initiate abstinence in the first week benefited more from extended treatment than patients continuously abstinent from week 1 [OR 1.7 (1.2, 2.4); P = 0.0015 versus OR 1.1 (0.8, 1.5); P = 0.6995, respectively; with the interaction of the quit pattern with treatment effect reaching...

  17. Periods and Superstring Amplitudes

    Stieberger, S

    2016-01-01

    Scattering amplitudes which describe the interaction of physical states play an important role in determining physical observables. In string theory the physical states are given by vibrations of open and closed strings and their interactions are described (at the leading order in perturbation theory) by a world-sheet given by the topology of a disk or sphere, respectively. Formally, for scattering of N strings this leads to N-3-dimensional iterated real integrals along the compactified real axis or N-3-dimensional complex sphere integrals, respectively. As a consequence the physical observables are described by periods on M_{0,N} - the moduli space of Riemann spheres of N ordered marked points. The mathematical structure of these string amplitudes share many recent advances in arithmetic algebraic geometry and number theory like multiple zeta values, single-valued multiple zeta values, Drinfeld, Deligne associators, Hopf algebra and Lie algebra structures related to Grothendiecks Galois theory. We review the...

  18. Periodic and limit-periodic discrete Schr\\"odinger operators

    Krueger, Helge

    2011-01-01

    The theory of discrete periodic and limit-periodic Schr\\"odinger operators is developed. In particular, the Floquet--Bloch decomposition is discussed. Furthermore, it is shown that an arbitrarily small potential can add a gap for even periods. In dimension two, it is shown that for coprime periods small potential terms don't add gaps thus proving a Bethe--Sommerfeld type statement. Furthermore limit-periodic potentials whose spectrum is an interval are constructed.

  19. Transition from non-periodic to periodic explosions.

    Cartes, Carlos; Descalzi, Orazio

    2015-12-13

    We show the existence of periodic exploding dissipative solitons. These non-chaotic explosions appear when higher-order nonlinear and dispersive effects are added to the complex cubic-quintic Ginzburg-Landau equation modelling soliton transmission lines. This counterintuitive phenomenon is the result of period-halving bifurcations leading to order (periodic explosions), followed by period-doubling bifurcations (or intermittency) leading to chaos (non-periodic explosions). PMID:26527807

  20. A 4-day critical period in corticosteroids treatment for traumatic optic neuropathy%皮质类固醇治疗外伤性视神经病变的四天关键时期

    Soon Lek Yap; Angeline Diong Ching Nga; Nadir Ah Mohamed AH; Visvaraj'a Subrayan

    2008-01-01

    目的:评估静脉注射甲基强的松龙(IVMP)对外伤性视神经病变患者的疗效.方法:回顾性分析2000-01至2007-06我院收治的16例外伤性视神经病变(TON)患者的临床资料.1g甲基强的松龙分3d静脉应用,然后口服泼尼松龙11d,并逐渐减量.记录从损伤开始到治疗开始的时间.视力变化是本研究结果的主要功能评价指标.在入院时,治疗后1,2,3d;1wk和1mo时,分别记录最佳矫正视力(BCVA).结果:共有16例患者纳入本研究,平均年龄为30岁,其中男性14例、女性2例.引起TON的主要原因有摩托车事故(占69%),打架斗殴(占19%)和体育运动(占12%).所有患者都表现有相对传入性瞳孔障碍.在损伤后4d内开始静脉注射甲基强的松龙,采用Snellen视力表检查视力,绝大部分(56%)患者视力提高超过3行或大于等于0.5(6/12).在损伤后5d以上才开始用类固醇治疗,视力则没有任何进步.结论:治疗TON,静脉注射中等到大剂量甲基强的松龙仍将起到重要作用.静脉注射甲基强的松龙治疗TON可能存在伤后4d的关键时期,超过了这个时期,该治疗可能就毫无效果.但还需要有更多的研究来为我们提供有明显统计学意义的数据.%·AIM: To evaluate the outcome of intravenous methyl-prednisolone ( IVMP) in patients with traumatic optic neuropathy (TON).·METHODS: Clinical data of 16 patients with TON who were admitted to our hospital from January 2000 to June 2006 were retrospectively analyzed. 1g of IVMP in divided doses for 3 days followed by a reducing dose of oral prednisolone for 11 days were given. Timing between the onset of injury and the initiation of treatment was noted.A change in visual acuity is the primary functional outcome measure of this study. Best corrected visual acuity (BCVA) was recorded at admission, on day 1, day 2, day 3, 1 week and 1 month after treatment.·RESULTS; Sixteen patients were included in this study with a mean age of 30. Fourteen of

  1. On solving periodic Riccati equations

    Varga, Andreas

    2008-01-01

    Numerically reliable algorithms to compute the periodic non-negative definite stabilizing solutions of the periodic differential Riccati equation (PRDE) and discrete-time periodic Riccati equation (DPRE) are proposed. For the numerical solution of PRDEs, a new multiple shooting-type algorithm is developed to compute the periodic solutions in an arbitrary number of time moments within one period by employing suitable discretizations of the continuous-time problems. In contrast to single shooti...

  2. 妊娠期输尿管结石并发顽固性肾绞痛的微创治疗%Minimally invasive treatment of ureteral calculi with period of refractory renal colic during pregnancy

    卢文武; 张建育; 刘榕臻; 李毅宁; 王明镑; 洪传芳

    2014-01-01

    Objective To evaluate the safety and efifcacy of treatment of refractory renal colic due to ureteric calculi during pregnancy. Methods In our hospital in September 2009 to June 2014, clinical data of 18 pregnant women with refractory renal colic due to ureteric calculi in my hospital were collected and retrospectively analyzed.13 cases received intra-ureteral double-J cannula alone. 5 cases received intra-ureteral double-J cannula after ureteroscopic pneumatic lithotripsy. Results Renal colic was relieved in 18 cases after operation. All the pregnant women had normal delivery and gave birth to healthy babies. Conclusion For pregnant women with refractory renal colic due to ureteric calculi, intra-ureteral cannula alone and intra-ureteral double-J cannula after ureteroscopic pneumatic lithotripsy treatment are safe and effective.%目的:探讨妊娠期输尿管结石并发顽固性肾绞痛的微创治疗的安全性及疗效。方法对我院2009年9月~2014年6月,共18例妊娠期输尿管结石并发顽固性肾绞痛的患者,进行回顾性分析。13例患者采用输尿管置管术,5例患者采用输尿管镜气压弹道碎石+输尿管置管术治疗。结果18例患者肾绞痛都得到有效缓解,均顺利生产,婴儿健康。结论对妊娠期输尿管结石并发顽固性肾绞痛患者采用输尿管置管术、输尿管镜气压弹道碎石+输尿管置管术等微创外科治疗技术,是安全有效的。

  3. El tratamiento mediático del dopaje en el periodo de transición democrática = Media treatment of doping during the democratic transition period

    Noemí García Arjona

    2013-04-01

    Full Text Available La actualidad deportiva no deja de mostrarnos el enorme impacto mediático del dopaje, y la importancia de cómo el deportista objeto de sospecha aparece expuesto, ya sea para alabarlo o para juzgarlo. Sin embargo, esta relación ya tiene sus precedentes en la historia reciente, siendo el periodo del tardofranquismo y la transición democrática clave para la sociedad y para el deporte en el contexto español, y que tomamos como referencia. A través de la prensa especializada (Marca, Mundo Deportivo, As, se va a analizar el papel histórico que los medios deportivos en España han desempeñado con relación al atleta sospechoso de dopaje: unas veces bajo la “ley del silencio”, otras bajo una aparente ingenuidad, y en ocasiones comprensivos con las vicisitudes del deportista.----------------------------------------------------------------------------Current sport situation continues to show the enormous media impact of doping, and the importance of how the athlete under suspicion appears exposed, either to praise or to judge. However, this relationship has its precedents in recent history, having as reference the period of the last years of Franco’s regime and early times of democratic transition, due to its importance for the society as well as for sport in the Spanish context. Through the specialized press (Marca, Mundo Deportivo, As, we will analyze the historical role played sports media in Spain related to the athlete suspected of doping: sometimes under the “law of silence”, sometimes under an apparent naivety, and in other cases, comprehensive to the difficulties of the athlete.

  4. The B-VITAGE trial: A randomized trial of homocysteine lowering treatment of depression in later life

    van Bockxmeer Frank

    2010-01-01

    Full Text Available Abstract Background Depression is a leading cause of disability worldwide and depressive symptoms are common in later life. Observational evidence suggests that depression is more prevalent among people with high plasma homocysteine (tHcy, but the results of randomized trials to date have been unable to show that lowering tHcy through the supplementation of vitamins B6, B12 and folate benefits depressive symptoms. We designed the B-VITAGE trial to determine whether adjunctive treatment with vitamins B6, B12 and folate increases the efficacy of standard antidepressant treatment. Methods/Design The B-VITAGE trial is a 12-month randomized, double-blind, placebo-controlled trial of daily citalopram (20 to 40 mg plus B12(0.4 mg, B6 (25 mg and folic acid (2 mg or citalopram (20 to 40 mg plus placebo for the treatment of depression in later life. The trial aims to recruit over 300 older adults with major depression (DSM-IV and has been powered to detect the impact of an intervention associated with moderate effect size. Depressive symptoms will be rated with the Montgomery-Åsberg Depression Rating Scale (MADRS. The trial has two main outcomes of interest: a reduction of 50% or more in the MADRS total score between baseline and week 12 and the remission of the depressive episode at weeks 12, 26 and 52 according to DSM-IV criteria. We hypothesize that subjects randomly allocated to the vitamin arm of the study will be more likely to show a clinically significant improvement and achieve and maintain remission of symptoms at 12, 26 and 52 weeks. Secondary outcomes of interest include compliance with treatment, reduction in the severity of depressive symptoms, switching to different antidepressants, the use of non-pharmacological antidepressant treatments, response to treatment according to MTHFRC677T genotype, and changes in cognitive function over 52 weeks. Conclusions The results of this trial will clarify whether the systematic use of B

  5. Influence of advancing age on clinical presentation, treatment efficacy and safety, and long-term outcome of pre-excitation syndromes: a retrospective cohort study of 961 patients included over a 25-year period

    Brembilla-Perrot, Béatrice; Olivier, Arnaud; Sellal, Jean-Marc; Manenti, Vladimir; Brembilla, Alice; Villemin, Thibaut; Admant, Philippe; Beurrier, Daniel; Bozec, Erwan; Girerd, Nicolas

    2016-01-01

    Objectives There are very little data on pre-excitation syndrome (PS) in the elderly. We investigated the influence of advancing age on clinical presentation, treatment and long-term outcome of PS. Setting Single-centre retrospective study of patient files. Participants In all, 961 patients (72 patients ≥60 years (mean 68.5±6), 889 patients <60 years (mean 30.5±14)) referred for overt pre-excitation and indication for electrophysiological study (EPS) were followed for 5.3±5 years. Usual care included 24 h Holter monitoring, echocardiography and EPS. Patients underwent accessory pathway (AP) ablation if necessary. Primary and secondary outcome measures Occurrence of atrial fibrillation (AF) or procedure-induced adverse event. Results Electrophysiological data and recourse to AP ablation (43% vs 48.5%, p=0.375) did not significantly differ between the groups. Older patients more often had symptomatic forms (81% vs 63%, p=0.003), history of spontaneous AF (8% vs 3%, p=0.01) or adverse presentation (poorly tolerated arrhythmias: 18% vs 7%, p=0.0009). In multivariable analysis, patients ≥60 years had a significantly higher risk of history of AF (OR=4.2, 2.1 to 8.3, p=0.001) and poorly tolerated arrhythmias (OR=3.8, 1.8 to 8.1, p=0.001). Age ≥60 years was associated with an increased major AP ablation complication risk (10% vs 1.9%, p=0.006). During follow-up, occurrence of AF (13.9% vs 3.6%, p<0.001) and incidence of poorly tolerated tachycardia (4.2% vs 0.6%, p=0.001) were more frequent in patients ≥60 years, although frequency of ablation failure or recurrence was similar (20% vs 15.5%, p=0.52). In multivariable analysis, patients ≥60 years had a significantly higher risk of AF (OR=2.9, 1.2 to 6.8, p≤0.01). Conclusions In this retrospective monocentre study, patients ≥60 years referred for PS work up appeared at higher risk of AF and adverse presentation, both prior and after the work up. These results suggest that, in elderly

  6. The redoubtable ecological periodic table

    Ecological periodic tables are repositories of reliable information on quantitative, predictably recurring (periodic) habitat–community patterns and their uncertainty, scaling and transferability. Their reliability derives from their grounding in sound ecological principle...

  7. A new characterization of periodic oscillations in periodic difference equations

    Al-Salman, Ahmad [Department of Mathematics and Statistics, Sultan Qaboos University, P.O. Box 36, PC 123, Al-Khod (Oman); AlSharawi, Ziyad, E-mail: alsha1zm@alsharawi.info [Department of Mathematics and Statistics, Sultan Qaboos University, P.O. Box 36, PC 123, Al-Khod (Oman)

    2011-11-15

    Highlights: > A characterization of periodic solutions of periodic difference equations is given. > The periods are classified as multiples and non-multiples of the phase-period. > Non-multiples of the phase-period depend on the intersections between the maps. > A refinement of Sharkovsky's theorem for periodic difference equations is given. - Abstract: In this paper, we characterize periodic solutions of p-periodic difference equations. We classify the periods into multiples of p and nonmultiples of p. We show that the elements of the set of multiples of p follow the well-known Sharkovsky's ordering multiplied by p. On the other hand, we show that the elements of the set {Gamma}{sub p} of nonmultiples of p are independent in their existence. Moreover, we show the existence of a p-periodic difference equation with infinite {Gamma}{sub p}-set in which the maps are defined on a compact domain and agree exactly on a countable set. Based on the proposed classification, we give a refinement of Sharkovsky's theorem for periodic difference equations.

  8. 两种术式治疗婴幼儿期舌系带过短的效果比较%Comparison of the Effects of Two Surgical Treatments on Short Lingual Frenulum in Infantile Period

    于在湖; 胡青芳; 杜衍晓

    2014-01-01

    目的:在临床上比较舌系带剪断术和舌系带矫正术治疗舌系带过短患儿的效果。方法选择的研究对象为在2007年2月-2014年2月期间,该院收治的200例舌系带过短的患儿,将这200例患儿随机分为给予舌系带矫正术治疗的对照组和给予舌系带剪断术实验组,每组100例,然后将对照组患儿与实验组患儿术后出血、感染以及发音等情况进行比较。结果实验组患儿在术后出现出血、感染发生率明显低于对照组患儿,组间差异有统计学意义(P0.05)。结论两种手术均可应用于舌系带过短的治疗,应用舌系带剪断术治疗舌系带过短的患儿,在术后出血、感染以及肿胀等方面的发生率上低于舌系带矫正术,但在患儿发音的改善上弱于上舌系带矫正术。%Objective To compare the clinical effect of treating children with too short tongue tie with tongue tie cut surgery and surgical correction of lingual frenum. Methods 200 children with too short lingual frenulum admitted in our hospital from February 2007 to February 2014 were selected as the subjects and randomly divided into two groups, the control group was treated by surgi-cal correction of lingual frenum, and the experimental group was treated by tongue tie cut surgery. Both groups had 100 children. And then the children in the control group and the experimental group were compared by postoperative bleeding, infection, and pronunciation and so on. Results The incidence of postoperative bleeding and infection of the experimental group was significantly lower than that of the control group, the difference between the groups was statistically significant (P0.05). Conclusion Both surgeries can be applied to the treatment of short tongue tie. Compared with surgical correc-tion of lingual frenum, children treated by tongue tie cut surgery have lower incidence of postoperative bleeding, infection and swelling, but weaker improvement of

  9. Periods and elementary real numbers

    Yoshinaga, Masahiko

    2008-01-01

    The periods, introduced by Kontsevich and Zagier, form a class of complex numbers which contains all algebraic numbers and several transcendental quantities. Little has been known about qualitative properties of periods. In this paper, we compare the periods with hierarchy of real numbers induced from computational complexities. In particular we prove that periods can be effectively approximated by elementary rational Cauchy sequences. As an application, we exhibit a computable real number wh...

  10. Periodic paralysis: clinical evaluation in 20 patients

    Célia Harumi Tengan; Acary S. Bulle de Oliveira; Alberto Alain Gabbai

    1994-01-01

    Twenty patients with periodic paralysis were evaluated and the aspects studied included epidemiological data, clinical manifestations, ancillary tests, treatment and evolution. Sixteen patients had the hypokalemic form (5 familiar, 5 sporadic, 5 thyrotoxic and 1 secondary). No patient with the normokalemic form was detected. Predominance of men was found (14 patients), especially in the cases with hyperthyroidism (5 patients). No thyrotoxic patient was of oriental origin. Only 4 patients had ...

  11. Clinical Profile in Hypokalemic Periodic Paralysis Cases

    Agrawal, Amit

    2014-01-01

    The present article was aimed to study demographic and clinical pattern, periodicity and precipitating events for hypokalemic paralysis and to assess the response to treatment both during acute attacks and as prophylaxis in comparison with available literature. Forty patients with hypokalemic paralysis were admitted in Narayana Medical College and Hospital during the last two years, in all the medical units and neurology wards. Patients were assessed clinically, with symptomatology and precip...

  12. Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis.

    Tawil, R; McDermott, M P; Brown, R; Shapiro, B C; Ptacek, L J; McManis, P G; Dalakas, M C; Spector, S A; Mendell, J R; Hahn, A F; Griggs, R C

    2000-01-01

    Although the carbonic anhydrase inhibitors have been used in the treatment of the primary periodic paralyses (PPs), their efficacy has not been demonstrated in double-blind, placebo-controlled trials. Therefore, we tested the efficacy of dichlorphenamide (DCP; Daranide), a potent carbonic anhydrase inhibitor, in the treatment of episodic weakness in the primary PPs. We performed two multicenter, randomized, double-blind, placebo-controlled crossover trials, one involving 42 subjects with hypokalemic periodic paralysis (HypoPP) and the other involving 31 subjects with potassium-sensitive periodic paralysis (PSPP). In each trial, two 8-week treatment periods were separated by an active washout period of at least 9 weeks. The primary outcome variable in the HypoPP trial was the occurrence of an intolerable increase in attack severity or frequency (end point). The primary outcome variable in the PSPP trial was the number of attacks per week. In the HypoPP trial, there were 13 subjects who exhibited a preference (in terms of the end point) for either DCP or placebo, and 11 of these preferred DCP. In the PSPP trial, DCP significantly reduced attack rates relative to placebo. DCP also significantly reduced attack rates relative to placebo in the HypoPP subjects. We conclude that DCP is effective in the prevention of episodic weakness in both HypoPP and PSPP. PMID:10632100

  13. Clinical effect of trichosanthes arctium lappa decoction combined with external application of mirabilite in the treatment of acute mastitis stagnation period%瓜蒌牛蒡汤加减联合芒硝外敷治疗急性乳腺炎郁滞期的临床观察

    李幸运

    2014-01-01

    目的:探讨瓜蒌牛蒡汤加减联合芒硝外敷治疗急性乳腺炎郁滞期的临床效果,进一步指导临床。方法选取2012年1月~2014年1月在本院门诊治疗的急性乳腺炎郁滞期患者60例,按照随机对照的原则,将患者分为观察组和对照组,每组各30例,观察组30例患者给予瓜蒌牛蒡汤加减联合芒硝外敷治疗,对照组30例患者给予单纯的硫酸镁湿热敷治疗,观察对比两组的临床治疗效果以及治疗时间。结果观察组治疗总有效率明显优于对照组,差异具有统计学意义(P<0.05),观察组的治疗时间明显少于对照组,差异具有统计学意义(P<0.05)。结论瓜蒌牛蒡汤加减联合芒硝外敷治疗急性乳腺炎郁滞期临床疗效显著,降低了脓肿的形成,有效的减轻患者的痛苦,保证母乳喂养率。%Objective To discuss the clinical effect of trichosanthes arctium lappa decoction combined with external application of mirabilite in the treatment of acute mastitis stagnation period for further clinical guide. Methods Choosing 60 patients with acute mastitis stagnation period from January 2012 to January 2014 in our hospital, outpatient treatment of patients, according to the principle of randomized controlled, the patients were divided into observation group and control group, 30 cases in each group, the observation group of 30 cases were treated with trichosanthes arctium lappa decoction combined with external application of mirabilite treatment, 30 cases in the control group were treated with magnesium sulfate wet compress simple treatment, the clinical therapeutic effect of two groups were compared and the treatment time. Results In observation group, the total efficiency of treatment was better than the control group, the difference was significant, with statistical significance(P<0.05), the treatment time of observation group was less than that of control group, the difference was significant, with

  14. Periodic waves in nonlinear metamaterials

    Periodic waves are presented in this Letter. With symbolic computation, equations for monochromatic waves are studied, and analytic periodic waves are obtained. Factors affecting properties of periodic waves are analyzed. Nonlinear metamaterials, with the continuous distribution of the dielectric permittivity obtained, are different from the ones with the discrete distribution. -- Highlights: ► Equations for the monochromatic waves in transverse magnetic polarization have been studied. ► Analytic periodic waves for the equations have been obtained. ► Periodic waves are theoretically presented and studied in the nonlinear metamaterials.

  15. Randomised controlled trial of counseling sessions, antidepressant medication, and combined treatment for major depression in primary care setting

    The study was made to determine whether counseling sessions using Egan's model combined with antidepressant medication is more effective than either treatment alone in the management of major depression in primary care. Patient aged 18 years and above with major depression on the research diagnostic criteria - a score of 13 or more on the 17 items. Hamilton rating scale for depression and a minimum duration of 4 weeks. Counseling sessions based on Egan's Model by research family physician or antidepressant medication or combination of both was performed. Hamilton rating scale for depression, Beck depression inventory, clinical interview schedule, and modified social adjustment schedule were used and assessed at 6 , 12 and 52 weeks. Patients in all groups showed a clear improvement after 12 weeks. The combination of counseling sessions and antidepressant medication is more effective than either treatment alone. Counseling sessions used by a trained family physician is an effective treatment for depressive disorders in primary care. The combination of this treatment with antidepressant medication is more effective than either treatment alone. (author)

  16. Nonparametric Inference for Periodic Sequences

    Sun, Ying

    2012-02-01

    This article proposes a nonparametric method for estimating the period and values of a periodic sequence when the data are evenly spaced in time. The period is estimated by a "leave-out-one-cycle" version of cross-validation (CV) and complements the periodogram, a widely used tool for period estimation. The CV method is computationally simple and implicitly penalizes multiples of the smallest period, leading to a "virtually" consistent estimator of integer periods. This estimator is investigated both theoretically and by simulation.We also propose a nonparametric test of the null hypothesis that the data have constantmean against the alternative that the sequence of means is periodic. Finally, our methodology is demonstrated on three well-known time series: the sunspots and lynx trapping data, and the El Niño series of sea surface temperatures. © 2012 American Statistical Association and the American Society for Quality.

  17. Positive periodic solutions of delayed periodic Lotka-Volterra systems

    Lin, Wei; Chen, Tianping

    2005-01-01

    In this Letter, for a general class of delayed periodic Lotka-Volterra systems, we prove some new results on the existence of positive periodic solutions by Schauder's fixed point theorem. The global asymptotical stability of positive periodic solutions is discussed further, and conditions for exponential convergence are given. The conditions we obtained are weaker than the previously known ones and can be easily reduced to several special cases.

  18. Positive periodic solutions of delayed periodic Lotka-Volterra systems

    Lin Wei [Laboratory of Nonlinear Mathematics Science, Institute of Mathematics, Fudan University, Shanghai 200433 (China)]. E-mail: weilin@fudan.edu.cn; Chen Tianping [Laboratory of Nonlinear Mathematics Science, Institute of Mathematics, Fudan University, Shanghai 200433 (China)]. E-mail: tchen@fudan.edu.cn

    2005-01-17

    In this Letter, for a general class of delayed periodic Lotka-Volterra systems, we prove some new results on the existence of positive periodic solutions by Schauder's fixed point theorem. The global asymptotical stability of positive periodic solutions is discussed further, and conditions for exponential convergence are given. The conditions we obtained are weaker than the previously known ones and can be easily reduced to several special cases.

  19. Fractional-period excitations in continuum periodic systems

    We investigate the generation of fractional-period states in continuum periodic systems. As an example, we consider a Bose-Einstein condensate confined in an optical-lattice potential. We show that when the potential is turned on nonadiabatically, the system explores a number of transient states whose periodicity is a fraction of that of the lattice. We illustrate the origin of fractional-period states analytically by treating them as resonant states of a parametrically forced Duffing oscillator and discuss their transient nature and potential observability

  20. Dynamics of Coulombic and gravitational periodic systems

    Kumar, Pankaj; Miller, Bruce N.

    2016-04-01

    We study the dynamics and the phase-space structures of Coulombic and self-gravitating versions of the classical one-dimensional three-body system with periodic boundary conditions. We demonstrate that such a three-body system may be reduced isomorphically to a spatially periodic system of a single particle experiencing a two-dimensional potential on a rhombic plane. For the case of both Coulombic and gravitational versions, exact expressions of the Hamiltonian have been derived in rhombic coordinates. We simulate the phase-space evolution through an event-driven algorithm that utilizes analytic solutions to the equations of motion. The simulation results show that the motion exhibits chaotic, quasiperiodic, and periodic behaviors in segmented regions of the phase space. While there is no evidence of global chaos in either the Coulombic or the gravitational system, the former exhibits a transition from a completely nonchaotic phase space at low energies to a mixed behavior. Gradual yet striking transitions from mild to intense chaos are indicated with changing energy, a behavior that differentiates the spatially periodic systems studied in this Rapid Communication from the well-understood free-boundary versions of the three-body problem. Our treatment of the three-body systems opens avenues for analysis of the dynamical properties exhibited by spatially periodic versions of various classes of systems studied in plasma and gravitational physics as well as in cosmology.

  1. Three cases of thyrotoxic periodic paralysis due to painless thyroiditis

    Debmalya Sanyal; Moutusi Raychaudhuri; Shakya Bhattacharjee

    2013-01-01

    We present three cases of thyrotoxic periodic paralysis (TPP) due to painless thyroiditis presenting as acute quadriparesis. All responded to potassium supplementation and propranolol. TPP may be due to thyrotoxicosis of any etiology, commonly Grave's disease. The absence of clinical signs of thyrotoxicosis can delay diagnosis and treatment. Thyroid function tests should be a routine evaluation in all cases of hypokalemic periodic paralysis.

  2. Periodic paralysis: clinical evaluation in 20 patients

    Célia Harumi Tengan

    1994-12-01

    Full Text Available Twenty patients with periodic paralysis were evaluated and the aspects studied included epidemiological data, clinical manifestations, ancillary tests, treatment and evolution. Sixteen patients had the hypokalemic form (5 familiar, 5 sporadic, 5 thyrotoxic and 1 secondary. No patient with the normokalemic form was detected. Predominance of men was found (14 patients, especially in the cases with hyperthyroidism (5 patients. No thyrotoxic patient was of oriental origin. Only 4 patients had the hyperkalemic form (3 familiar, 1 sporadic. Attacks of paralysis began during the first decade in the hyperkalemic form and up to the third decade in the hypokalemic. In both forms the attacks occurred preferentially in the morning with rest after exercise being the most important precipitating factor. Seventy five percent of the hyperkalemic patients referred brief attacks (<12 hours. Longer attacks were referred by 43% of the hypokalemic patients. The majority of the attacks manifested with a generalized weakness mainly in legs, and its frequency was variable. Creatinokinase was evaluated in 10 patients and 8 of them had levels that varied from 1,1 to 5 times normal. Electromyography was done in 6 patients and myotonic phenomenon was the only abnormality detected in 2 patients. Carbonic anhydrase inhibitors, especially acetazolamide, were used for prophylactic treatment in 9 pacients with good results in all. Although periodic paralysis may be considered a benign disease we found respiratory distress in 5 patients, permanent myopathy in 1, electrocardiographic abnormalities during crises in 4; death during paralysis occurred in 2. Therefore correct diagnosis and immediate treatment are crucial. This study shows that hyperthyroidism is an important cause of periodic paralysis in our country, even in non oriental patients. Hence endocrine investigation is mandatory since this kind of periodic paralysis will only be abated after return to the euthyroid state.

  3. Photolysis of Periodate and Periodic Acid in Aqueous Solution

    Sehested, Knud; Kläning, U. K.

    1978-01-01

    The photochemistry of periodate and periodic acid in aqueous solution was studied (i) by quantum yield measurements at low light intensity (ii) by flash photolysis, and (iii) by photolysis of glassy samples at 77 K. The photochemical studies were supplemented with pulse radiolysis studies of...

  4. From Periodic Properties to a Periodic Table Arrangement

    Besalú, Emili

    2013-01-01

    A periodic table is constructed from the consideration of periodic properties and the application of the principal components analysis technique. This procedure is useful for objects classification and data reduction and has been used in the field of chemistry for many applications, such as lanthanides, molecules, or conformers classification.…

  5. Repelling periodic points of given periods of rational functions

    CHANG; Jianming; FANG; Mingliang

    2006-01-01

    Let R(z) be a rational function of degree d ≥ 2. Then R(z) has at least one repelling periodic point of given period k ≥ 2, unless k = 4 and d=2, or k= 3 and d ≤ 3, or k=2 and d≤8. Examples show that all exceptional cases occur.

  6. Scaling limits of periodic monopoles

    Maldonado, Rafael

    2015-01-01

    The purpose of this note is to explore the structure of singly periodic monopoles for different values of the size to period ratio. The transition between a chain of small monopoles and the approximately two dimensional chain of large monopoles takes us through a region with an unintuitive dependence on the periodic direction. The focus is mainly on the smooth SU(2) monopole of charge 2.

  7. Scaling limits of periodic monopoles

    Maldonado, Rafael

    2014-01-01

    The purpose of this note is to explore the structure of singly periodic monopoles for different values of the size to period ratio. The transition between a chain of small monopoles and the approximately two dimensional chain of large monopoles takes us through a region with an unintuitive dependence on the periodic direction. The focus is mainly on the smooth SU(2) monopole of charge 2.

  8. Ap stars with variable periods

    Mikulášek, Zdeněk; Krtička, Jiří; Janík, Jan; Zejda, Miloslav; Henry, Gegory W.; Paunzen, Ernst; Žižňovský, Jozef; Zverko, Juraj

    2013-01-01

    The majority of magnetic chemically peculiar (mCP) stars exhibit periodic light, magnetic, radio, and spectroscopic variations that can be adequately modelled as a rigidly-rotating main-sequence star with persistent surface structures. Nevertheless, there is a small sample of diverse mCP stars whose rotation periods vary on timescales of decades while the shapes of their phase curves remain unchanged. Alternating period increases and decreases have been suspected in the hot CP stars CU Vir an...

  9. Holonomic systems for period mappings

    Chen, Jingyue, E-mail: jychen@brandeis.edu [Department of Mathematics, Brandeis University, Waltham, MA 02454 (United States); Huang, An, E-mail: anhuang@math.harvard.edu [Department of Mathematics, Harvard University, Cambridge, MA 02138 (United States); Lian, Bong H., E-mail: lian@brandeis.edu [Department of Mathematics, Brandeis University, Waltham, MA 02454 (United States)

    2015-09-15

    Period mappings were introduced in the sixties [4] to study variation of complex structures of families of algebraic varieties. The theory of tautological systems was introduced recently [7,8] to understand period integrals of algebraic manifolds. In this paper, we give an explicit construction of a tautological system for each component of a period mapping. We also show that the D-module associated with the tautological system gives rise to many interesting vanishing conditions for period integrals at certain special points of the parameter space.

  10. Clinical Observation of Low-dosage and Long-period Xeloda in Treatment of Advanced Triple Negative Breast Cancer%低剂量长周期希罗达治疗复发晚期三阴性乳腺癌的临床研究

    容景瑜; 张少贤; 黄景彬; 林清; 陈雁秋

    2015-01-01

    目的:观察低剂量长周期希罗达治疗复发晚期三阴性乳腺癌的有效性和安全性。方法将60例经含希罗达联合化疗8个周期后疾病达缓解或稳定的复发晚期三阴性乳腺癌患者随机分为两组,治疗组继续接受低剂量长周期希罗达维持治疗,期间进展或不能耐受毒副反应者停止化疗,对照组予以观察随诊。结果低剂量长周期希罗达维持治疗复发晚期三阴性乳腺癌有效率为73.3%,中位无进展生存期为413.7天,半数患者生存期为466.3天,化疗有效维持时间为209.3天;1年生存率70.0%,2年生存率46.6%;患者生存质量提高,肿瘤指标下降,与对照组比较,有显著性差异。主要毒副反应为手足综合征(36.67%),多为Ⅰ-Ⅱ度,其次为消化道反应(26.67%)及白细胞下降(23.3%),患者可耐受。结论低剂量长周期希罗达治疗复发晚期三阴性乳腺癌,患者的耐受性好,不良反应程度低,治疗有效,为治疗复发性三阴性乳腺癌的有效、低毒的可选方案。%Objective To observe the therapeutic effects, toxicity and side effects of low-dosage and long-period xeloda in the treatment of advanced triple negative breast cancer. Methods Sixty patients with advanced triple negative breast cancer were divided into two groups after treatment of 8 cycles’combination regimen including xeloda. 30 patients in control group then got no xeloda but follow-up clinic, and another 30 in treatment group were still treated by low-dosage and long-period xeloda. Results In the treatment group, the short-term therapeutic effect rate was 73.3%, the median progression-free sur-vival (PFS) was 413.7 days. The median survival time was 466.3 days, the effective chemotherapy-maintained time was 209.3 days, with 1-year survival of 70.0%, 2-year survival of 46.6%. The life quality of patients was improved and the level of tumor marker was decreased with

  11. Dyes Waste Treatments

    Siew-Teng Ong

    2011-02-01

    Full Text Available Dyes waste represent one of the problematic groups of pollutants because their presence can be easily identified by the human eye and they are not easily biodegradable. This literature review paper highlights and provides an overview of dyes waste treatments for 3 years period, from 2008–2010. The noteworthy treatment processes for dyes waste include biological treatment, catalytic oxidation, filtration, sorption process and combination treatments.

  12. Periodic and aperiodic synchronization in skilled action

    Fred Cummins

    2011-12-01

    Full Text Available Synchronized action is considered as a manifestation of shared skill. Most synchronized behaviors in humans and other animals are based on periodic repetition. Aperiodic synchronization of complex action is found in the experimental task of synchronous speaking, in which naive subjects read a common text in lock step. The demonstration of synchronized behavior without a periodic basis is presented as a challenge for theoretical understanding. A unified treatment of periodic and aperiodic synchronization is suggested by replacing the sequential processing model of cognitivist approaches with the more local notion of a task-specific sensorimotor coordination. On this view, skilled action is the imposition of constraints on the co-variation of movement and sensory flux such that the boundary conditions that define the skill are met. This non-cognitivist approach originates in the work of John Dewey. It allows a unification of the treatment of sensorimotor synchronization in simple rhythmic behavior and in complex skilled behavior and it suggests that skill sharing is a uniquely human trait of considerable import.

  13. Quasi-periodicity in relative quasi-periodic tori

    Fassò, Francesco; García-Naranjo, Luis C.; Giacobbe, Andrea

    2015-10-01

    At variance from the cases of relative equilibria and relative periodic orbits of dynamical systems with symmetry, the dynamics in relative quasi-periodic tori (namely, subsets of the phase space that project to an invariant torus of the reduced system on which the flow is quasi-periodic) is not yet completely understood. Even in the simplest situation of a free action of a compact and abelian connected group, the dynamics in a relative quasi-periodic torus is not necessarily quasi-periodic. It is known that quasi-periodicity of the unreduced dynamics is related to the reducibility of the reconstruction equation, and sufficient conditions for it are virtually known only in a perturbation context. We provide a different, though equivalent, approach to this subject, based on the hypothesis of the existence of commuting, group-invariant lifts of a set of generators of the reduced torus. Under this hypothesis, which is shown to be equivalent to the reducibility of the reconstruction equation, we give a complete description of the structure of the relative quasi-periodic torus, which is a principal torus bundle whose fibers are tori of a dimension which exceeds that of the reduced torus by at most the rank of the group. The construction can always be done in such a way that these tori have minimal dimension and carry ergodic flow.

  14. Clinical utility of dronabinol in the treatment of weight loss associated with HIV and AIDS

    Badowski, Melissa E; Perez, Sarah E

    2016-01-01

    Since the beginning of the HIV/AIDS epidemic, weight loss has been a common complaint for patients. The use of various definitions defining HIV wasting syndrome has made it difficult to determine its actual prevalence. Despite the use of highly active antiretroviral therapy, it is estimated that the prevalence of HIV wasting syndrome is between 14% and 38%. HIV wasting syndrome may stem from conditions affecting chewing, swallowing, or gastrointestinal motility, neurologic disease affecting food intake or the perception of hunger or ability to eat, psychiatric illness, food insecurity generated from psychosocial or economic concerns, or anorexia due to medications, malabsorption, infections, or tumors. Treatment of HIV wasting syndrome may be managed with appetite stimulants (megestrol acetate or dronabinol), anabolic agents (testosterone, testosterone analogs, or recombinant human growth hormone), or, rarely, cytokine production modulators (thalidomide). The goal of this review is to provide an in-depth evaluation based on existing clinical trials on the clinical utility of dronabinol in the treatment of weight loss associated with HIV/AIDS. Although total body weight gain varies with dronabinol use (–2.0 to 3.2 kg), dronabinol is a well-tolerated option to promote appetite stimulation. Further studies are needed with standardized definitions of HIV-associated weight loss and clinical outcomes, robust sample sizes, safety and efficacy data on chronic use of dronabinol beyond 52 weeks, and associated virologic and immunologic outcomes. PMID:26929669

  15. Superconductivity and the periodic table

    Compiled data on superconducting transition temperature Tc for pure metals (including amorphous and high-pressure phases) from the first, second, and third long periods of the Periodic Table and for their analogous compounds show that a significant regularity exists in the relative values of Tc

  16. Beyond the periodic orbit theory

    Cvitanovic, Predrag; Hansen, Kim; Rolf, Juri; Vattay, Gabor

    1997-01-01

    The global constraints on chaotic dynamics induced by the analyticity of smooth flows are used to dispense with individual periodic orbits and derive infinite families of exact sum rules for several simple dynamical systems. The associated Fredholm determinants are of particularly simple polynomial form. The theory developed suggests an alternative to the conventional periodic orbit theory approach to determining eigenspectra of transfer operators.

  17. Periodicities in gamma ray bursts

    Gamma ray burst models based on magnetic neutron stars face a problem of account for the scarcity of observed periods. Both this scarcity and the typical period found when any is detected are explained if the neutron stars are accreting in binary systems

  18. Obesity and exercise in adoloscent period

    Eda Mendeş

    2011-10-01

    Full Text Available Adolescence period is a special period during which fastest growth and development occur in humans and which includes transition from childhood to adulthood. World Health Organization (WHO define 10-19 age-group individuals as adolescence and 15- 24 age-group individuals as youthood. That today’s community lacks knowledge of workout, inadequate awareness of the benefits of workout to human health and acceptance of the continuity of sedentary life gives rise to the incidence of lots of chronic diseases such as high-blood pressure, cardio-pulmonary diseases, obesity and diabetes.In recent years, childhood and adolescence obesity has become an important health problem as a result of the decline in physical activities. In this context, workout along with balanced diet is one of the precautions that can be suggested in terms of the prevention of obesity. The purpose of this study (compilation is to provide information on keeping human health by means of an awareness of workout in adolescence period which is the most important stage preceding adulthood; to summarize the issue in relation to the written documents existing in the relevant literature, and to make suggestions about healthy future generations through workout in adolescence period.In conclusion, successful results regarding the treatment of obesity in adolescence can be achieved through aerobics along with low-calorie diet.

  19. Transition Period and Immunosuppression: Critical Period of Dairy Cattle Reproduction

    K. Simenew; M. Wondu

    2013-01-01

    This seminar study is prepared on the objectives of: revising important aspects of transition period of dairy cattle and highlighting some potential areas of research and challenges for the future. It has sufficiently been discussed that improved understanding of this frontier of the biology, immunology, nutrition and management of cows during the transition period will provide the largest gains in productivity and profitability of dairy farms. In the manuscript under each specific topic, tra...

  20. Optical Periodicity Analysis of 3C 446 using Period04

    Fei Guo; Hao Jing Zhang

    2014-09-01

    All the data of the blazar 3C446 at 8, 4.8, 14 and 22 GHz, presented in publications from 1977 to 2006, have been compiled to generate light curves. The light curves show violent activity of 3C446. Using Period04 analysis method, we have found that there is a period of 7.2 yr, which is consistent with the results that we found using wavelet analysis method. We get the instability region as = 123.83.

  1. Thyrotoxic Hypokalemic Periodic Paralysis: A Case Report

    Murat Atmaca

    2012-12-01

    Full Text Available Thyrotoxic hypokalemic periodic paralysis is a rare complication of thyrotoxicosis. This clinic condition is often encountered in Asian populations and male gender while thyrotoxicosis is frequently seen in women. The escape of potassium into cell is the mechanism responsible for this disease and its etiology is not completely known. Thyroid hormones, carbohydrate rich diet, alcohol consumption and excessive exercise are regarded as the precipitating factors. This clinical picture is generally difficult to define at first attack. Here, we report a forty-two-year-old male patient with Basedow-Graves disease who was diagnosed as having thyrotoxic hypokalemic periodic paralysis during the first paralytic attack. His symptoms improved after potassium replacement and treatment with beta-blocker and antithyroid drugs. The permanent cure was achieved with radioactive iodine ablation therapy. Turk Jem 2012; 16: 69-71

  2. Entanglement Entropy of Periodic Sublattices

    He, Temple; Vandoren, Stefan

    2016-01-01

    We study the entanglement entropy (EE) of Gaussian systems on a lattice with periodic boundary conditions, both in the vacuum and at nonzero temperatures. By restricting the reduced subsystem to periodic sublattices, we can compute the entanglement spectrum and EE exactly. We illustrate this for a free (1+1)-dimensional massive scalar field at a fixed temperature. Consistent with previous literature, we demonstrate that for a sufficiently large periodic sublattice the EE grows extensively, even in the vacuum. Furthermore, the analytic expression for the EE allows us probe its behavior both in the massless limit and in the continuum limit at any temperature.

  3. The Periodic Table in Croatia

    Raos, N.

    2011-12-01

    Full Text Available The Croatian (Yugoslav Academy of Sciences and Arts was the first academy to elect D. I. Mendeleev as its honorary member (1882, whereas the periodic table of the elements has been taught regularly at the Zagreb University since 1888. The early interest of Croatian chemists in the periodic table should be attributed primarily to their pan-Slavic attitude, particularly as proof that Slavic people were able to produce "their own Newtons" (M. V. Lomonosov and D. I. Mendeleev. Such enthusiastic views, however, did not help in analyzing the contribution of Mendeleev and other scientists to the discovery and development of the periodic table of the elements.

  4. Effect of Simo decoction,Clostridium butyricnm powder in treatment of neonatal asphyxia during perinatal period after feeding intolerance%四磨汤与酪酸梭菌活菌散治疗新生儿围生期窒息后喂养不耐受的观察

    卓文娟

    2012-01-01

    [目的]观察四磨汤、酪酸梭菌活菌散治疗新生儿围生期窒息后喂养不耐受的情况. [方法]选择本院有围生期窒息后喂养不耐受的新生儿68例为实验对象,并随机分为对照组(n=36)和治疗组(n=32),羊水有胎粪污染者,两组均予洗胃,洗胃后禁食6h才开奶,对照组予枯草杆菌二联活菌颗粒治疗,治疗组予四磨汤、酪酸梭菌活菌散治疗.每天记录呕吐的次数、呕吐量、进食的奶量、大便次数、腹胀消失的日龄、恢复出生体重的日龄等. [结果]实验组呕吐次数减少、呕吐及腹胀消失时间提前、达50 kCal/(kg·d)日龄,恢复出生体重的日龄均提前,差异有统计学意义(P<0.05).[结论]四磨汤、酪酸梭菌活菌散治疗新生儿围生期窒息后喂养不耐受,能促进胃肠功能成熟,提高喂养的耐受性,而且安全.%[Objective] To observe the effect of Simo decoction,the condition of intolerant infants under Clostridium butyricum powder in treatment of neonatal asphyxia during perinatal period after feeding. [Methods] 68 infants selected as cases and were randomly divided into the control group (n=36) and treatment group (n = 32) cases with amniotic fluid meconium pollution in two groups were treated with gastric lav-age,after gastric lavage they could not open the milk until fasting for 6 hours. The control group received the treatment of Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines,Live,and the treatment group was treated with the Simo decoction,Clostridium bulyricutn powder treatment,daily record of vomiting,amount of milk,stool frequency,abdominal distention disappeared days of age,the days of birth weight,such as age of recovery. [Results] The experimental group reduced frequency of vomiting ,and vomiting, abdominal distension disappeared ahead of time,up to 50 kCal/Ckg·) days in advance, to restore the birth weight of the days in advance,with statistically significant (P<0. 05

  5. Thyrotoxic periodic paralysis: a short clinical review

    Rashmi Aggarwal

    2015-06-01

    Full Text Available Thyrotoxic Periodic Paralysis (TPP is a potentially lethal manifestation of hyperthyroidism which is characterized by hypokalemia and muscular weakness. It mainly affects Asian men in the age group of 20 to 40 years. Immediate supplementation with oral or intravenous potassium will help to not only abort the acute attack of paralysis but will also prevent serious and life threatening cardiac arrhythmias. Non selective beta blockers like propranolol can also be used to ameliorate and prevent subsequent paralytic attack. Acetazolamide has no role in the treatment of TPP. [Int J Res Med Sci 2015; 3(3.000: 539-542

  6. Periodicities in photospheric magnetic flux

    2006-01-01

    Magnetic field plays an important role in solar structure and activity. In principle, the determination of magnetic flux would provide the best general-purpose index of solar activity. Currently, the periodicity studies corresponding to photospheric magnetic flux (PMF) are very few possibly due to the absence of a uniform flux sequence. In this paper, by using 383 NSO/Kitt Peak magnetic synoptic charts we reconstruct a flux sequence from February 1975 to August 2003 and perform a relatively systemic periodicity analysis with two methods of the Scargle periodogram and the Morlet wavelet transform. As a result, four periods are found at around 1050, 500, 300 and 160 days. We analyze these periods' temporal variabilities in detail and discuss their respective origins briefly.

  7. Modular forms and period polynomials

    Pasol, Vicentiu

    2012-01-01

    We study the space of period polynomials associated with modular forms for finite index subgroups of the modular group. For the full modular group, this space is endowed with a pairing, corresponding to the Petersson inner product on modular forms via a formula of Haberland, and with an action of Hecke operators, defined algebraically by Zagier. We extend Haberland's formula to arbitrary modular forms for finite index subgroups of the modular group, and we show that it conceals two stronger formulas. We extend the action of Hecke operators to \\Gamma_0(N) and \\Gamma_1(N), and we prove algebraically that the pairing on period polynomials appearing in Haberland's formula is Hecke equivariant. Two indefinite theta series identities follow from this proof. We give two ways of determining the extra relations satisfied by the even and odd parts of period polynomials associated with cusp forms, which are independent of the period relations.

  8. Periodicities in Aerosol Optical Depths

    Ramachandran, S; Verma, Amit; Panigrahi, Prasanta K

    2011-01-01

    We investigate the temporal and spatial variability in aerosol optical depth (AOD) over different geographic locations in India due to their important role in the earth-atmosphere radiation budget. The use of continuous wavelet transform pinpoints the spatio-temporal non-stationarity of the periodic variations in the AOD depending on local factors. The optimal time-frequency localization ability of Morlet wavelet accurately isolates the periodic features in the different frequency domains, to study the variations in the dominant periods due to local effects. The origin of the effects on the periodic modulations is then related to physical phenomena of regional nature, which throws considerable light on the observed variations in aerosol optical depths. We also find the phase relationship between different locations and to identify the possible correlations between different geographic locations and related environmental variations.

  9. AKTIVITAS PADA SKELET KRANIOFASIAL SELAMA PERIODE PERTUMBUHAN

    Magdalena Lesmana

    2015-07-01

    Full Text Available The human skull is a complicated structure made up from 20 constituent bones and it is thus not surprising that the pattern of growth is complicated. The fully grown skull is not simple a larger version of the infant form. The adult skull differs not only in size but also in shape, indicating that theremust be a process of differential growth. The differential growth process must be a different activity seen in the craniofacial skelet, during the growing period and it may be divided into four components. Knowledge of craniofacial growth provides a background to the understanding of the treatment planning process and to undertake suitable interceptive treatment, to hinder the stomatognathic function problems in the future.

  10. The Periodic Table in Croatia

    Raos, N.

    2011-01-01

    The Croatian (Yugoslav) Academy of Sciences and Arts was the first academy to elect D. I. Mendeleev as its honorary member (1882), whereas the periodic table of the elements has been taught regularly at the Zagreb University since 1888. The early interest of Croatian chemists in the periodic table should be attributed primarily to their pan-Slavic attitude, particularly as proof that Slavic people were able to produce "their own Newtons" (M. V. Lomonosov and D. I. Mendeleev). Such enthusiasti...