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Sample records for 510k blood establishment

  1. Premarket Notifications (510(k)s)

    U.S. Department of Health & Human Services — Medical device manufacturers are required to submit a premarket notification or 510(k) if they intend to introduce a device into commercial distribution for the...

  2. Blood Establishment Registration Database

    U.S. Department of Health & Human Services — This application provides information for active, inactive, and pre-registered firms. Query options are by FEI, Applicant Name, Establishment Name, Other Names,...

  3. 78 FR 26786 - 510(k) Device Modifications: Deciding When To Submit a 510(k) for a Change to an Existing Device...

    2013-05-08

    ..., the Quality System Regulation, at 61 FR 52620 (October 7, 1996), in the response to comment 83... HUMAN SERVICES Food and Drug Administration 510(k) Device Modifications: Deciding When To Submit a 510(k... Administration (FDA) is announcing the public meeting entitled ``510(k) Device ] Modifications: Deciding When...

  4. 75 FR 47307 - Center for Devices and Radiological Health 510(k) Working Group Preliminary Report and...

    2010-08-05

    ... Decision Making Preliminary Report and Recommendations; Availability; Request for Comments AGENCY: Food and... of Science in Regulatory Decision Making. Volume I is entitled ``510(k) Working Group Preliminary... Regulatory Decision Making Preliminary Report and Recommendations.'' The recommendations contained in...

  5. Specific heat of rhenium disulfide in 360-510 K temperature range

    Isobaric specific heat of rhenium disulfide was measured by the method of differential scanning calorimetry in the range of 360-510 K. Thermodynamic functions of rhenium disulfide were calculated using literature data on standard entropy of the compound for the range of 296.15-600 K. 3 refs., 1 fig., 2 tabs

  6. Adverse blood transfusion outcomes: establishing causation.

    Isbister, James P; Shander, Aryeh; Spahn, Donat R; Erhard, Jochen; Farmer, Shannon L; Hofmann, Axel

    2011-04-01

    The transfusion of allogeneic red blood cells (RBCs) and other blood components is ingrained in modern medical practice. The rationale for administering transfusions is based on key assumptions that efficacy is established and risks are acceptable and minimized. Despite the cliché that, "the blood supply is safer than ever," data about risks and lack of efficacy of RBC transfusions in several clinical settings have steadily accumulated. Frequentist statisticians and clinicians demand evidence from randomized clinical trials (RCTs); however, causation for the recognized serious hazards of allogeneic transfusion has never been established in this manner. On the other hand, the preponderance of evidence implicating RBC transfusions in adverse clinical outcomes related to immunomodulation and the storage lesion comes from observational studies, and a broad and critical analysis to evaluate causation is overdue. It is suggested in several circumstances that this cannot wait for the design, execution, and conduct of rigorous RCTs. We begin by examining the nature and definition of causation with relevant examples from transfusion medicine. Deductive deterministic methods may be applied to most of the well-accepted and understood serious hazards of transfusion, with modified Koch's postulates being fulfilled in most circumstances. On the other hand, when several possible interacting risk factors exist and RBC transfusions are associated with adverse clinical outcomes, establishing causation requires inferential probabilistic methodology. In the latter circumstances, the case for RBC transfusions being causal for adverse clinical outcomes can be strengthened by applying modified Bradford Hill criteria to the plethora of existing observational studies. This being the case, a greater precautionary approach to RBC transfusion is necessary and equipoise that justifying RCTs may become problematic. PMID:21345639

  7. Fixing a 510(K) Loophole: In Support of The Sound Devices Act of 2012

    Ho, Shuenn (Patrick)

    2014-01-01

    The current medical device regulatory system contains a dangerous loophole. While the voluntary recall of a harmful medical device removes it from the market, new devices that claim they are substantially equivalent to the recalled device can still reach the market through the 510(k) premarket notification process. Devices that have gained regulatory clearance in this fashion have caused considerable harm and are much more likely to be recalled for safety reasons as well. The recently propo...

  8. A rational framework for production decision making in blood establishments.

    Ramoa, Augusto; Maia, Salomé; Lourenço, Anália

    2012-01-01

    SAD_BaSe is a blood bank data analysis software, created to assist in the management of blood donations and the blood production chain in blood establishments. In particular, the system keeps track of several collection and production indicators, enables the definition of collection and production strategies, and the measurement of quality indicators required by the Quality Management System regulating the general operation of blood establishments. This paper describes the general scenario of blood establishments and its main requirements in terms of data management and analysis. It presents the architecture of SAD_BaSe and identifies its main contributions. Specifically, it brings forward the generation of customized reports driven by decision making needs and the use of data mining techniques in the analysis of donor suspensions and donation discards. PMID:22829575

  9. 78 FR 100 - Guidance for Industry and Food and Drug Administration Staff; Refuse To Accept Policy for 510(k)s...

    2013-01-02

    ... checklists for use by FDA review staff. In the Federal Register of August 13, 2012 (77 FR 48159), FDA...; Refuse To Accept Policy for 510(k)s; Availability AGENCY: Food and Drug Administration, HHS. ACTION... entitled ``Refuse to Accept Policy for 510(k)s.'' The purpose of this document is to explain the...

  10. 21 CFR 862.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act). 862.9 Section 862.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CLINICAL CHEMISTRY...

  11. 21 CFR 607.65 - Exemptions for blood product establishments.

    2010-04-01

    ... certified under the Clinical Laboratory Improvement Amendments of 1988 (42 U.S.C. 263a) and 42 CFR part 493... the profession of pharmacy including the business of dispensing and selling blood products at...

  12. 78 FR 18353 - Guidance for Industry: Blood Establishment Computer System Validation in the User's Facility...

    2013-03-26

    ... validation of computer systems in the user's facility, the guidance does not address the software... HUMAN SERVICES Food and Drug Administration Guidance for Industry: Blood Establishment Computer System... ``Guidance for Industry: Blood Establishment Computer System Validation in the User's Facility'' dated...

  13. The value to blood establishments of supplier quality audit and of adopting a European Blood Alliance collaborative approach

    Nightingale, Mark J.; Ceulemans, Jan; Ágoston, Stephanie; van Mourik, Peter; Marcou-Cherdel, Céline; Wickens, Betty; Johnstone, Pauline

    2014-01-01

    Background The assessment of suppliers of critical goods and services to European blood establishments is a regulatory requirement proving difficult to resource. This study was to establish whether European Blood Alliance member blood services could collaborate to reduce the cost of auditing suppliers without diminishing standards. Materials and method Five blood services took part, each contributing a maximum of one qualified auditor per audit (rather than the usual two). Four audits were completed involving eight auditors in total to a European Blood Alliance agreed policy and process using an audit scope agreed with suppliers. Results Audits produced a total of 22 observations, the majority relating to good manufacturing practice and highlighted deficiencies in processes, procedures and quality records including complaints’ handling, product recall, equipment calibration, management of change, facilities’ maintenance and monitoring and business continuity. Auditors reported that audits had been useful to their service and all audits prompted a positive response from suppliers with satisfactory corrective action plans where applicable. Audit costs totalled € 3,438 (average € 860 per audit) which is no more than equivalent traditional audits. The four audit reports have been shared amongst the five participating blood establishments and benefitted 13 recipient departments in total. Previously, 13 separate audits would have been required by the five blood services. Discussion Collaborative supplier audit has proven an effective and efficient initiative that can reduce the resource requirements of both suppliers and individual blood service’s auditing costs. Collaborative supplier audit has since been established within routine European Blood Alliance management practice. PMID:24553596

  14. [Establishing an umbilical cord blood bank for unrelated allogenic stem cell transplantation].

    Tichelli, A; Surbek, D; Huxol, H; Schmolck, C; John, L; Wicki, R; Hoffmann, T; Wodnar-Filipowicz, A; Passweg, J; Kühne, T; Imbach, P; Holzgreve, W; Gratwohl, A

    1998-10-17

    We report the establishment of a cord-blood bank in a routine hematological laboratory. Cord-blood collection was performed with placenta in utero by a trained team and immediately sent to the cord-blood bank. There, 6.8 ml cord-blood was used for analysis of nucleated cell counts, counts of CD34-positive cells, CFU's, complete HLA-typing, ABO and Rhesus blood groups, bacteriologic cultures and serology for HIV 1 and 2, HbsAg, HVC, CMV, syphilis and toxoplasmosis. The cord-blood collection was frozen and conserved at -192 degrees C. From each cord-blood vials of DNA, viable cells and plasma were cryopreserved. Between June 1997 and April 1998, 54 cord-bloods were collected. 40 of them were cryo-preserved, and 14 discarded because of low cell counts. The median volume was 109 ml with 1.4 x 10(9) nucleated cells. The in vitro capacity of proliferation of the cord-blood correlated well with the absolute counts of CD34-positive cells (r = 0.93), moderately with the relative counts of CD34 (r = 0.68) as well as the nucleated cells (r = 0.70), poorly with the volume (r = 0.44). Three of the 40 (7.5%) cord-blood products contained a bacterial contamination. This study shows that a cord-blood bank can be organised in a routine hematological laboratory, which is familiar with transplantation products. However, the procedure is time consuming, expensive and requires a highly qualified team and specialised technical equipment. PMID:9824889

  15. Quality management in European screening laboratories in blood establishments: A view of current approaches and trends.

    Pereira, Paulo; Westgard, James O; Encarnação, Pedro; Seghatchian, Jerard; de Sousa, Gracinda

    2015-04-01

    The screening laboratory has a critical role in the post-transfusion safety. The success of its targets and efficiency depends on the management system used. Even though the European Union directive 2002/98/EC requires a quality management system in blood establishments, its requirements for screening laboratories are generic. Complementary approaches are needed to implement a quality management system focused on screening laboratories. This article briefly discusses the current good manufacturing practices and good laboratory practices, as well as the trends in quality management system standards. ISO 9001 is widely accepted in some European Union blood establishments as the quality management standard, however this is not synonymous of its successful application. The ISO "risk-based thinking" is interrelated with the quality risk-management process of the EuBIS "Standards and criteria for the inspection of blood establishments". ISO 15189 should be the next step on the quality assurance of a screening laboratory, since it is focused on medical laboratory. To standardize the quality management systems in blood establishments' screening laboratories, new national and European claims focused on technical requirements following ISO 15189 is needed. PMID:25765135

  16. Establishment of a molecular tool for blood meal identification in Malaysia

    Ernieenor Faraliana Che Lah; Mariana Ahamad; Mohd Subail Haron; Ho Tze Ming

    2012-01-01

    Objective: To establish a polymerase chain reaction (PCR) technique based on cytochrome b (cytb) gene of mitochondria DNA (mtDNA) for blood meal identification. Methods: The PCR technique was established based on published information and validated using blood sample of laboratory animals of which their whole gene sequences are available in GenBank. PCR was next performed to compile gene sequences of different species of wild rodents. The primers used were complementary to the conserved region of the cytb gene of vertebrate’s mtDNA. A total of 100 blood samples, both from laboratory animals and wild rodents were collected and analyzed. The obtained unknown sequences were compared with those in the GenBank database using BLAST program to identify the vertebrate animal species. Results: Gene sequences of 11 species of wild animals caught in 9 localities of Peninsular Malaysia were compiled using the established PCR. The animals involved were Rattus (rattus) tanezumi, Rattus tiomanicus, Leopoldamys sabanus,Tupaia glis, Tupaia minor, Niviventor cremoriventor, Rhinosciurus laticaudatus, Callosciurus caniseps, Sundamys muelleri, Rattus rajah and Maxomys whiteheadi. The BLAST results confirmed the host with exact or nearly exact matches (>89% identity). Ten new gene sequences have been deposited in GenBank database since September 2010. Conclusions: This study indicates that the PCR direct sequencing system using universal primer sets for vertebrate cytb gene is a promising technique for blood meal identification.

  17. Establishment of rat model of opening blood-brain barrier with conventional whole-brain irradiation

    Objective: To establish a rat model of opening blood-brain barrier with conventional whole-brain irradiation. Methods: According to different dosage of irradiation, a hundred Sprague-Dowley rats were randomly assigned into five groups, the control group (no irradiation), and four irradiated groups at 10 grays, 20 grays, 30 grays and 40 grays. The rats were administered to conventional fraction irradiation (2 Gy/day and 5 days a week) with routine 60Co gamma-rays. The intake of feed and autonomic activities were observed every day. Changes in skin and hair in the irradiated field, body weight, and center nervous system symptoms and signs were examined and recorded every week during irradiation. The neurological status was ranked on a scale based on the Mickley's Scale. Ultrastructure changes of blood-brain barrier at 16 hours after the last irradiation were examined with electron microscope using lanthanum trace labeling. Results: Neither abnormal nervous sign, nor change of feed intake, skin and hair was observed in all the rats. No statistically significant difference of body weight was observed among the five groups (P>0.05). The effect that radiation can directly damage the function and structure of blood-brain barrier was proportional to irradiation doses. Conclusion: This rat model is a suitable for study on blood-brain barrier pathophysiology and molecular biology after conventional whole-brain irradiation. (authors)

  18. Establishment and performance assessment of preparation technology of internal quality control products for blood transfusion compatibility testing

    Yu, Yang; MA, CHUNYA; Feng, Qian; Chen, Xin; GUAN, XIAOZHEN; Zhang, Xiaojuan; Chen, Linfeng; Lin, Zilin; Pan, Jichun; Zhang, Ting; Luo, Qun; Wang, Deqing

    2013-01-01

    The aim of this study was to establish and to optimize the preparation technology of whole blood internal quality control (IQC) products for blood transfusion compatibility testing. Several B-type RhD-negative blood samples collected from healthy donors were mixed. Two groups of whole blood IQC products, namely, the preservative solution group (PS group) and the saline group, were prepared. The agglutination intensity of IQC sample red cells and anti-B antibody, IgM anti-A antibody and revers...

  19. 77 FR 46096 - Statistical Process Controls for Blood Establishments; Public Workshop

    2012-08-02

    ... Whole Blood and blood components; (2) statistical methods used for biologic product quality control; (3...: Statistical process control is the application of statistical methods to the monitoring, or quality control... monitors manufacturing procedures, validation summaries, and quality control data prior to licensure...

  20. Establishment of long-term monocyte suspension cultures from normal human peripheral blood

    1982-01-01

    The long-term suspension growth of normal, immature myeloid cells from fresh human cord blood was recently reported and required cells separated on supplemented discontinuous Percoll gradients, growth in media containing hydrocortisone and vitamins D3, and gentle, continuous agitation (13). When normal adult bone marrow (six donors) or blood from Epstein-Barr virus (EBV)-seropositive donors (nine donors) was used as a source of fresh human leukocytes, only short-term proliferation of myeloid ...

  1. Establishing a public umbilical cord blood stem cell bank for South Africa: an enquiry into public acceptability.

    Meissner-Roloff, Madelein; Pepper, Michael S

    2013-12-01

    South Africa (SA) faces a large unmet need for bone marrow (BM) transplantation, which could be alleviated in part by establishing a public umbilical cord blood stem cell bank (UCB SCB). Umbilical cord blood is an increasingly utilised source of hematopoietic stem cells for BM transplantation in addition to BM or mobilized peripheral blood stem cells. Establishing a public UCB SCB would therefore be a positive step towards improving the quality of health care in SA by providing for an important unmet need. This study takes the form of an enquiry into the acceptability of establishing a public bank through an interview with and questionnaire completed by mothers-to-be in the antenatal clinic of a large public hospital in SA. Initial results are positive, with 85 % of the participants in favour of establishing a public UCB SCB in SA. This initial probe will serve as a model for a more comprehensive national enquiry into public support and acceptability in different clinics, hospitals and provinces in SA. PMID:23943126

  2. In vitro model of the blood-brain barrier established by co-culture of primary cerebral microvascular endothelial and astrocyte cells

    Yan Wang; Ning Wang; Biao Cai; Guang-yun Wang; Jing Li; Xing-xing Piao

    2015-01-01

    Drugs for the treatment and prevention of nervous system diseases must permeate the blood-brain barrier to take effect. In vitro models of the blood-brain barrier are therefore important in the investigation of drug permeation mechanisms. However, to date, no unified method has been described for establishing a blood-brain barrier model. Here, we modified an in vitro model of the blood-brain barrier by seeding brain microvascular endothelial cells and astrocytes from newborn rats on a polyest...

  3. Blood supply of the insular cortex of Cercopithecus Aethiops: Another approach to establish non-human primate model for addiction

    Filipović Branislav

    2008-01-01

    Full Text Available The non-human primate model has already been applied in studies about alcoholism in the last decade, demonstrating a high confidence level of similarities between humans and non-human monkeys. Authors indented to establish the definitive model for addiction by investigating the insular blood supply in Cercopithecus Aethiops. In 23 out of 24 Latex injected adult brains, the insula received blood supplied by the M2 segment of the middle cerebral artery (MCA. The cortex was supplied by two separate trunks, while perforating branches originating directly from MCA, individually, or together with lateral striate (lenticulostriate arteries. Their average caliber was about 120 µm, and the number of its branches ranged from 2 to 9. No left - right asymmetries have been recorded. Similarities with the human vascular pattern have been studied. .

  4. In vitro model of the blood-brain barrier established by co-culture of primary cerebral microvascular endothelial and astrocyte cells

    Yan Wang

    2015-01-01

    Full Text Available Drugs for the treatment and prevention of nervous system diseases must permeate the blood-brain barrier to take effect. In vitro models of the blood-brain barrier are therefore important in the investigation of drug permeation mechanisms. However, to date, no unified method has been described for establishing a blood-brain barrier model. Here, we modified an in vitro model of the blood-brain barrier by seeding brain microvascular endothelial cells and astrocytes from newborn rats on a polyester Transwell cell culture membrane with 0.4-µm pores, and conducted transepithelial electrical resistance measurements, leakage tests and assays for specific blood-brain barrier enzymes. We show that the permeability of our model is as low as that of the blood-brain barrier in vivo. Our model will be a valuable tool in the study of the mechanisms of action of neuroprotective drugs.

  5. The Food and Drug Administration Is Now Preparing to Establish Tighter Performance Requirements for Blood Glucose Monitors

    Klonoff, David C.

    2010-01-01

    On March 16 and 17, 2010, the Food and Drug Administration (FDA) presented a public meeting about blood glucose monitoring at the Gaithersberg Hilton Hotel. The meeting was intended to present expert opinions and solicit input from the public about whether to develop new regulatory policies for blood glucose monitors. The meeting was divided into three sections: (1) Clinical Accuracy Requirements for Blood Glucose Monitors, (2) Interferences and Limitations of Blood Glucose Monitors, and (3) ...

  6. Cerebral blood flow SPECT may be helpful in establishing the diagnosis of progressive supranuclear palsy and corticobasal degeneration

    We present 4 cases, which illustrate the usefulness of neuroimaging studies in atypical forms of Parkinsonism. Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD) are rare neurodegenerative progressive disorders of the central nervous system of unknown cause. The clinical accuracy in this diagnosis is not very high even in centres specialising in movement disorders. Functional imaging can be helpful in diagnosing PSP and CBD. We present the results of cerebral blood flow (CBF) SPECT scanning in 2 patients with PSP and 2 patients with CBD. This was performed using a triple-head gammacamera and 99mTc-HMPAO. In PSP patients a diffuse frontal perfusion deficit was seen, eventually with striatal and occipital hypoperfusion. CT/MRI was either normal or showed a diffuse cortical-subcortical atrophy. In CBD patients left fronto-parieto-temporal cortex and a striatal hypoperfusion were shown. CT scanning was normal in one case and showed an asymmetrical temporo-parietal atrophy in second one. The pattern of diffuse frontal perfusions deficit in PSP and asymmetrical, contralateral to symptoms of CBD, cortico-subcortical hypoperfusion may be helpful in establishing the correct diagnosis. (author)

  7. HMSRP Hawaiian Monk Seal Blood Values (Establishing hematology and serum chemistry reference ranges for wild Hawaiian Monk Seals)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hematology and serum chemistry evaluations are essential to a patients comprehensive health exam by providing measures of organ function, blood cell volume and...

  8. Scientific and Organizational Problems Connected with the Establishment of Bone-Marrow and Blood-Component Banks

    The author describes the results of studies carried out with a view to devising rational means for the long-term preservation of bone-marrow and blood cells at ultra- low temperatures. Attention is especially directed to freezing conditions and cryoprotective agents. The paper stresses the significance of the apparatus that has been constructed for programmed freezing operations and analyses the data regarding bone-marrow donors. The present level of knowledge in regard to the preservation of bone-marrow and blood components makes it possible to organize banks for their long-term storage, thereby permitting more extensive clinical use of bone-marrow transplantation and haemotherapy. (author)

  9. Role of dental pulp in identification of the deceased individual by establishing ABO blood grouping and Rhesus factor

    Nalini Aswath

    2012-01-01

    Conclusion: As the teeth are the hardest, most stable biological material, resist adverse environmental conditions and the pulpal tissue inside the teeth is well protected, the blood group antigen from pulp remains stable for long. Thus, the high potential value of dental pulp tissue is highlighted in this study.

  10. Establishment of a real-time PCR for quantifying transforming growth factor beta1 in blood of hepatocellular carcinoma patients

    2008-01-01

    Background: The carcinogenesis of hepatocellular carcinoma (HCC) is a multi-factorial, multistep and complex process. Its prognosis is poor and early detection is of the utmost importance. Transforming growth factor β1 (TGF-β1) message RNA (mRNA) has been reported to be elevated in HCC patients using Northern blotting. However, little work has been done about the detection of TGF-β1 mRNA levels in peripheral blood of patients with HCC using the real-time polymerase chain reactions (PCR) method. Objective: To assess the prognostic value of quantitative levels of TGF-β1 mRNA in peripheral blood of patients with HCC, and to investigate the relationship between the expression of TGF-β1 mRNA in peripheral blood and many diagnostic and pathological factors. Methods: We developed an optimized Taqman real-time PCR to quantify TGF-β1 mRNA in peripheral blood of 53 patients with HCC and 44 healthy volunteers. In addition, blood was collected from patients with HCC for measuring levels of total bilirubin (TBil), prealbumin, albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyltranspeptidase (GGT), alpha-L-fucosidase (AFU), alpha fetoprotein (AFP), carcino-embryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), viral load and platelet counts. Statistical analysis was performed using the SPSS software system (SPSS 10.0). Results: In real-time PCR, fluorescence was detectable in all blood specimens from patients with HCC and healthy volunteers. The levels of TGF-β1 mRNA expression in patients with HCC were significantly higher compared to that in healthy volunteers (P<0.000 1), suggesting an association of the activated TGF-β1 gene transcription with hepatocarcinogenesis. Patients with HCC were divided into 2 groups according to their TGF-β1 mRNA above (group A, n=28) or below (group B, n=25) the mean level. Statistical results demonstrated that TGF-β1 mRNA expression level was correlated with patients age, serum levels of CEA

  11. The re-establishment of the normal blood lactate response to exercise in humans after prolonged acclimatization to altitude

    Van Hall, Gerrit; Calbet, J A; Søndergaard, H; Saltin, B

    1. One to five weeks of chronic exposure to hypoxia has been shown to reduce peak blood lactate concentration compared to acute exposure to hypoxia during exercise, the high altitude 'lactate paradox'. However, we hypothesize that a sufficiently long exposure to hypoxia would result in a blood...... lowlanders acclimatized for 9 weeks to an altitude of 5260 m, the arterial lactate concentration was similar at 0 m acute hypoxia and 5260 m chronic hypoxia. The net lactate release from the active leg was higher at 5260 m chronic hypoxia compared to 0 m acute hypoxia, implying an enhanced lactate...... utilization with prolonged acclimatization to altitude. The present study clearly shows the absence of a lactate paradox in lowlanders sufficiently acclimatized to altitude....

  12. Establishing baseline levels of trace elements in blood and skin of bottlenose dolphins in Sarasota Bay, Florida: Implications for non-invasive monitoring

    Bryan, Colleen E. [National Institute of Standards and Technology, Hollings Marine Laboratory, 331 Fort Johnson Road, Charleston, South Carolina 29412 (United States); College of Charleston, Grice Marine Laboratory, 205 Fort Johnson Road, Charleston, South Carolina 29412 (United States)], E-mail: colleen.bryan@nist.gov; Christopher, Steven J. [National Institute of Standards and Technology, Hollings Marine Laboratory, 331 Fort Johnson Road, Charleston, South Carolina 29412 (United States); Balmer, Brian C.; Wells, Randall S. [Chicago Zoological Society c/o Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, Florida 34236 (United States)

    2007-12-15

    Several major unusual mortality events occurring in recent years have increased the level of concern for the health of bottlenose dolphin populations along the United States Atlantic and Gulf of Mexico coasts. Trace element concentrations were examined in a population of free-ranging dolphins in Sarasota Bay, Florida, in order to develop a benchmark for future comparisons within and between populations. Whole blood (n = 51) and skin (n = 40) samples were collected through capture and release health assessment events during 2002-2004. Samples were analyzed for Al, V, Cr, Mn, Cu, Zn, As, Se, Rb, Sr, Mo, Cd, and Pb by inductively coupled plasma mass spectrometry (ICPMS) and Hg via atomic fluorescence spectrometry (AFS). Trace element concentrations (wet mass) in skin were 2 to 45 times greater than blood, except Cu was approximately 1.5 times higher in blood. Statistically strong correlations (p < 0.05) were found for V, As, Se, Rb, Sr, and Hg between blood and skin demonstrating that these tissues can be used as effective non-lethal monitoring tools. The strongest correlation was established for Hg (r = 0.9689) and concentrations in both blood and skin were above the threshold at which detrimental effects are observed in other vertebrate species. Female dolphins had significantly greater Hg concentrations in blood and skin and Pb concentrations in skin, relative to males. Calves exhibited significantly lower V, As, and Hg concentrations in blood and V and Hg concentrations in skin, relative to other age classes. Rubidium and Cu concentrations in skin were greatest in subadults and calves, respectively. In blood, V, Zn, and As concentrations were significantly greater in winter, relative to summer, and the opposite trend was observed for Rb and Sr concentrations. In skin, Cu and Zn concentrations were significantly greater in winter, relative to summer, and the opposite trend was observed for Mn, Rb, Cd, and Pb concentrations. The baseline concentrations and trends

  13. Establishing baseline levels of trace elements in blood and skin of bottlenose dolphins in Sarasota Bay, Florida: Implications for non-invasive monitoring

    Several major unusual mortality events occurring in recent years have increased the level of concern for the health of bottlenose dolphin populations along the United States Atlantic and Gulf of Mexico coasts. Trace element concentrations were examined in a population of free-ranging dolphins in Sarasota Bay, Florida, in order to develop a benchmark for future comparisons within and between populations. Whole blood (n = 51) and skin (n = 40) samples were collected through capture and release health assessment events during 2002-2004. Samples were analyzed for Al, V, Cr, Mn, Cu, Zn, As, Se, Rb, Sr, Mo, Cd, and Pb by inductively coupled plasma mass spectrometry (ICPMS) and Hg via atomic fluorescence spectrometry (AFS). Trace element concentrations (wet mass) in skin were 2 to 45 times greater than blood, except Cu was approximately 1.5 times higher in blood. Statistically strong correlations (p < 0.05) were found for V, As, Se, Rb, Sr, and Hg between blood and skin demonstrating that these tissues can be used as effective non-lethal monitoring tools. The strongest correlation was established for Hg (r = 0.9689) and concentrations in both blood and skin were above the threshold at which detrimental effects are observed in other vertebrate species. Female dolphins had significantly greater Hg concentrations in blood and skin and Pb concentrations in skin, relative to males. Calves exhibited significantly lower V, As, and Hg concentrations in blood and V and Hg concentrations in skin, relative to other age classes. Rubidium and Cu concentrations in skin were greatest in subadults and calves, respectively. In blood, V, Zn, and As concentrations were significantly greater in winter, relative to summer, and the opposite trend was observed for Rb and Sr concentrations. In skin, Cu and Zn concentrations were significantly greater in winter, relative to summer, and the opposite trend was observed for Mn, Rb, Cd, and Pb concentrations. The baseline concentrations and trends

  14. #DDOD: Establishment Registration & Device Listing

    U.S. Department of Health & Human Services — SUMMARY DDOD use case to request means on consolidating multiple data sources (MDR, PMA, 510(k), R&L) in order to build a list of all marketed medical devices....

  15. Establishing baseline levels of trace elements in blood and skin of bottlenose dolphins in Sarasota Bay, Florida: implications for non-invasive monitoring.

    Bryan, Colleen E; Christopher, Steven J; Balmer, Brian C; Wells, Randall S

    2007-12-15

    Several major unusual mortality events occurring in recent years have increased the level of concern for the health of bottlenose dolphin populations along the United States Atlantic and Gulf of Mexico coasts. Trace element concentrations were examined in a population of free-ranging dolphins in Sarasota Bay, Florida, in order to develop a benchmark for future comparisons within and between populations. Whole blood (n=51) and skin (n=40) samples were collected through capture and release health assessment events during 2002-2004. Samples were analyzed for Al, V, Cr, Mn, Cu, Zn, As, Se, Rb, Sr, Mo, Cd, and Pb by inductively coupled plasma mass spectrometry (ICPMS) and Hg via atomic fluorescence spectrometry (AFS). Trace element concentrations (wet mass) in skin were 2 to 45 times greater than blood, except Cu was approximately 1.5 times higher in blood. Statistically strong correlations (pdolphins had significantly greater Hg concentrations in blood and skin and Pb concentrations in skin, relative to males. Calves exhibited significantly lower V, As, and Hg concentrations in blood and V and Hg concentrations in skin, relative to other age classes. Rubidium and Cu concentrations in skin were greatest in subadults and calves, respectively. In blood, V, Zn, and As concentrations were significantly greater in winter, relative to summer, and the opposite trend was observed for Rb and Sr concentrations. In skin, Cu and Zn concentrations were significantly greater in winter, relative to summer, and the opposite trend was observed for Mn, Rb, Cd, and Pb concentrations. The baseline concentrations and trends established in this study will serve as a benchmark for comparison and aid in sampling design for future monitoring of this population and other coastal bottlenose dolphin populations. PMID:17870146

  16. In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches.

    Wolff, Anette; Antfolk, Maria; Brodin, Birger; Tenje, Maria

    2015-09-01

    The societal need for new central nervous system (CNS) medicines is substantial, because of the global increase in life expectancy and the accompanying increase in age-related CNS diseases. Low blood-brain barrier (BBB) permeability has been one of the major causes of failure for new CNS drug candidates. There has therefore been a great interest in cell models, which mimic BBB permeation properties. In this review, we present an overview of the performance of monocultured, cocultured, and triple-cultured primary cells and immortalized cell lines, including key parameters such as transendothelial electrical resistance values, permeabilities of paracellular flux markers, and expression of BBB-specific marker proteins. Microfluidic systems are gaining ground as a new automated technical platform for cell culture and systematic analysis. The performance of these systems was compared with current state-of-the-art models and it was noted that, although they show great promise, these systems have not yet reached beyond the proof-of-concept stage. In general, it was found that there were large variations in experimental protocols, BBB phenotype markers, and paracellular flux markers used. It is the author's opinion that the field may benefit greatly from developing standardized methodologies and initiating collaborative efforts on optimizing culture protocols. PMID:25630899

  17. Establishment of Age- and Gender-Specific Reference Ranges for 36 Routine and 57 Cell Population Data Items in a New Automated Blood Cell Analyzer, Sysmex XN-2000

    Park, Sang Hyuk; Lee, Bo-Ra; Kim, Mi-Jeong; Han, Min-Young; Cho, Young-Uk; Jang, Seongsoo

    2016-01-01

    We established age- and gender-specific reference ranges for the 36 routine complete blood cell (CBC) and 57 cell population data (CPD) items in the Sysmex XN-2000 (Sysmex, Japan). In total, 280 peripheral blood samples were obtained from an equal number of healthy adults. Values for 36 routine items and 57 CPD items were obtained for each sample, and the results were categorized into six subgroups (N>39 in each subgroup) according to patient age (20-40, 41-60, and >60 yr) and gender (male and female), and compared with respect to age and gender differences. The majority of data items (22 of 36 routine CBC items and 44 of 57 CPD items) exhibited significant differences (P≤0.05) in their results with respect to age or gender, and several red cell-, lymphocyte-, and platelet-related data tended to decrease in women or older adults. These results provide a basis for establishing age- and gender-specific reference ranges for routine and CPD items in Sysmex XN-2000. Furthermore, these reference ranges could be used to determine clinical significance for new items of Sysmex XN-2000 in further studies. PMID:26915613

  18. Establishment of blood glucose fluctuation diabetic rats model%大鼠糖尿病血糖波动模型的建立

    廖洁; 雷闽湘; 胡维

    2010-01-01

    目的 探讨利用胰岛素建立大鼠糖尿病血糖波动模型.方法 取60只SD大鼠随机分成正常组(n=20)和模型组(n=40),高糖高脂饲料喂养模型组SD大鼠6周后用小剂量链尿佐菌素(STZ)30 mg/KS腹腔注射诱导建立糖尿病模型,模型成功后将其随机分成持续高糖组(n=20)和血糖波动组(n=20).血糖波动组大鼠每日2次皮下注射普通胰岛素诱导血糖波动,从而建立糖尿病大鼠血糖波动模型.观察大鼠"三多一少"症状,血糖变化情况.结果 (1)血糖波动组和持续组的"三多一少"症状明显.(2)血糖波动组的SDBG,LAGE明显高于正常组[(8.56 ±0.49)mmol/L vs (0.69 ±0.05)mmol/L,(23.15±2.51)mmol/L vs(2.14±0.52)mmol/L]及持续组[(8.56±0.49)mmol/L vs(3.25±0.26)mmol/L,(23.15±2.51)mmol/L vs(9.45±2.46)mmol/L],持续组的MBG(24.66±3.32)mmol/L高于正常组(6.10±0.75)mmol/L及波动组(18.16±8.91)mmoL/L.(3)持续组和波动组的24 h尿蛋白均较普通组明显增加[(100.38±7.99)mg/24 h vs(18.13±1.41)mg/24h,(123.71±11.23)mg/24 h vg(18.13±1.41)mg/24 h],差异有统计学意义(P<0.01),波动组较持续组增加[(123.71±11.23)mg/24 h ys(100.38±7.99)mg/24 h],差异有统计学意义(P<0.05).结论 使用每日皮下注射两次胰岛素的方法能成功制作出糖尿病大鼠血糖波动模型,并可作为研究血糖波动及其并发症的理想动物模型.%Objective To establish the blood glucose fluctuation diabetic rat model by subcutaneous injecting insulin. Method The male Sprague-Dawley (SD) rats were randomly assigned into two groups, normal group ( n =20) and model group ( n =40). Normal group rats were fed with normal diet, model group rats were fed with a high-sucrose-high-fat diet. After 6 weeks, a low dose of streptozotocin ( STZ ,30mg/kg) was injected to induce hyperglycemia in model group rats. And then the model group rats were ran-dom divided into two subgroups, diabetic group ( n = 20) and blood glucose fluctuation group ( n = 20

  19. The short-to-mid-term blood gas changes after TIPS with the shunting established at different sites of portal vein for the treatment of hepatopulmonary syndrome

    Objective: To discuss the short-to-mid-term blood gas changes in patients with hepatopulmonary syndrome (HPS) after receiving TIPS with the shunting established at different sites of portal vein. Methods: During the period from July 2008 to May 2013, transjugular intrahepatic portosystemic shunting (TIPS) was employed in treating clinically - proved HPS at the hospital. A total of 81 cases had complete material, and their clinical data were retrospectively analyzed. Of the 81 cases, shunting was established at the main branch of portal vein in 30 (group A), at the left branch of portal vein in 24 (Group B) and at the right branch of portal vein in 27 (Group C). After TIPS all the patients were followed up for 3- 12 months. With the patients laying in horizontal position and receiving no oxygen inhalation, A-aPO2, PaO2 and SO2 levels were determined both before and after TIPS. The results were analyzed and compared between each other among the three groups by using paired t-test. Results: Half months after TIPS, A-aPO2, PaO2 and SO2 levels of group A and group B showed a significant improvement when compared with those determined before TIPS (P<0.05), while no significant differences in A-aPO2, PaO2 and SO2 levels were found in group C after TIPS (P>0.05). Three months after TIPS, A-aPO2, PaO2 and SO2 levels of group A and group B still showed an obvious improvement when compared with those determined before TIPS (P<0.05), while in group C only the A-aPO2 level showed a significant improvement when compared with that determined before TIPS (P<0.05). Twelve months after TIPS, A-aPO2, PaO2 and SO2 levels of group B still showed a significant improvement when compared with those determined before TIPS (P<0.05), while those of group A and group C showed no significant changes when compared with those determined before TIPS (P>0.05). Conclusion: In performing TIPS for the treatment of hepatopulmonary syndrome, to establish the shunting at the main branch of portal vein

  20. Establishment of Elevated Serum Levels of IL-10, IL-8 and TNF-β as Potential Peripheral Blood Biomarkers in Tubercular Lymphadenitis: A Prospective Observational Cohort Study

    Abhimanyu; Bose, Mridula; Varma-Basil, Mandira; Jain, Ashima; Sethi, Tavpritesh; Tiwari, Pradeep Kumar; Agrawal, Anurag; Banavaliker, Jayant Nagesh; Bhowmick, Kumar Tapas

    2016-01-01

    Background Tubercular lymphadenitis (TL) is the most common form of extra-pulmonary tuberculosis (TB) consisting about 15–20% of all TB cases. The currently available diagnostic modalities for (TL), are invasive and involve a high index of suspicion, having limited accuracy. We hypothesized that TL would have a distinct cytokine signature that would distinguish it from pulmonary TB (PTB), peripheral tubercular lymphadenopathy (LNTB), healthy controls (HC), other lymphadenopathies (LAP) and cancerous LAP. To assess this twelve cytokines (Tumor Necrosis Factor (TNF)—α, Interferon (IFN) -γ, Interleukin (IL)-2, IL-12, IL-18, IL-1β, IL-10, IL-6, IL-4, IL-1Receptor antagonist (IL-1Ra), IL-8 and TNF-β, which have a role in pathogenesis of tuberculosis, were tested as potential peripheral blood biomarkers to aid the diagnosis of TL when routine investigations prove to be of limited value. Methods and Findings A prospective observational cohort study carried out during 2010–2013. This was a multi-center study with three participating hospitals in Delhi, India where through random sampling cohorts were established. The subjects were above 15 years of age, HIV-negative with no predisposing ailments to TB (n = 338). The discovery cohort (n = 218) had LNTB (n = 50), PTB (n = 84) and HC (n = 84). The independent validation cohort (n = 120) composed of patients with cancerous LAP (n = 35), other LAP (n = 20) as well as with independent PTB (n = 30), LNTB (n = 15) and HC (n = 20). Eight out of twelve cytokines achieved statistical relevance upon evaluation by pairwise and ROC analysis. Further, variable selection using random forest backward elimination revealed six serum biosignatures including IL-12, IL-4, IL-6, IL-10, IL-8 and TNF-β as optimal for classifying the LNTB status of an individual. For the sake of clinical applicability we further selected a three analyte panel (IL-8, IL-10 and TNF-β) which was subjected to multinomial modeling in the independent

  1. Blood profile holds clues to role of infection in a premonitory state for idiopathic parkinsonism and of gastrointestinal infection in established disease

    Charlett André

    2009-11-01

    Full Text Available Abstract The two-stage neuroinflammatory process, containment and progression, proposed to underlie neurodegeneration may predicate on systemic inflammation arising from the gastrointestinal tract. Helicobacter infection has been described as one switch in the pathogenic-circuitry of idiopathic parkinsonism (IP: eradication modifies disease progression and marked deterioration accompanies eradication-failure. Moreover, serum Helicobacter-antibody-profile predicts presence, severity and progression of IP. Slow gastrointestinal-transit precedes IP-diagnosis and becomes increasingly-apparent after, predisposing to small-intestinal bacterial-overgrowth (SIBO. Although IP is well-described as a systemic illness with a long prodrome, there has been no comprehensive overview of the blood profile. Here, it is examined in relation to Helicobacter status and lactulose-hydrogen-breath-testing for SIBO. A robust finding of reduced lymphocyte count in 126 IP-probands and 79 spouses (without clinically-definite IP, compared with that in 381 controls (p Helicobacter-status or breath-hydrogen. This complements a previous report that spouses were 'down-the-pathway' to 'clinically-definite' disease. In 205 other controls without clinically-definite IP, there were strong associations between sporadic cardinal features and immunoglobulin class concentration, not explained by Helicobacter-status. Premonitory states for idiopathic parkinsonism associated with relative lymphopenia, higher serum immunoglobulin concentrations and evidence of enteric-nervous-system damage may prove viral in origin. Although only 8% of the above 79 spouses were urea-breath-test-positive for Helicobacter, all 8 spouses with clinically-definite IP were (p Helicobacter-colonised recipient might result in progression to the diagnostic threshold. Twenty-five percent of the 126 probands were seropositive for anti-nuclear autoantibody. In 20 probands, monitored before and serially after anti

  2. Establishing and evaluating bar-code technology in blood sampling system: a model based on human centered human-centered design method

    Chou, Shin-Shang; Yan, Hsiu-Fang; Huang, Hsiu-Ya; Tseng, Kuan-Jui; Kuo, Shu-Chen

    2012-01-01

    This study intended to use a human-centered design study method to develop a bar-code technology in blood sampling process. By using the multilevel analysis to gather the information, the bar-code technology has been constructed to identify the patient’s identification, simplify the work process, and prevent medical error rates. A Technology Acceptance Model questionnaire was developed to assess the effectiveness of system and the data of patient’s identification and sample errors were collec...

  3. Establishment of a microplate assay for flow cytometric assessment and it is use for the evaluation of age-related phenotypic changes in canine whole blood leukocytes.

    Reis, Alexandre B; Carneiro, Cláudia M; Carvalho, Maria das Graças; Teixeira-Carvalho, Andréa; Giunchetti, Rodolfo C; Mayrink, Wilson; Genaro, Odair; Corrêa-Oliveira, Rodrigo; Martins-Filho, Olindo A

    2005-02-10

    The effectiveness of flow cytometric assays for canine use is still requiring standardization. Despite several studies using purified mononuclear cells, no methodology or reference ranges are available for immunophenotyping of whole blood leukocytes (WBL). Fresh and pre-fixed WBL were used to identify cell-subsets, (Thy-1(+)/CD5(+)/CD4(+)/CD8(+)/CD21(+) and CD14(+)) and measure MHC-II, CD45RA/CD45RB expression. We described here an efficient method for fast quantification of canine-WBL, using pre-fix in a microplate assay, which allows long-term sample storage prior to phenotyping. Decreased percentage of CD5(+)-T-cells within the lymphocyte-gate and increased percentage of CD21(+)-B-cells were observed in young animals, which led to higher T/B cell ratios in middle-aged dogs. Lower numerical counts of Thy-1(+), CD4(+), CD8(+) and CD21(+) lymphocyte were observed when compared to young animals. In addition, we identified an age-related decline of MHC-II/CD45RA expression by lymphocytes. We proposed an improved method for phenotyping of canine peripheral blood mononuclear cells (PBMC) that has significant use for researchers and veterinary clinicians. The hematological changes of senescence previously identified on PBMC could be adequately reproduced on features identified by whole blood. Furthermore, this study supplies normal range references as baseline standards for clinical purposes, besides specific immunological parameters to monitor canine aging process. PMID:15621304

  4. Strategies for Establishing Policy, Environmental, and Systems-Level Interventions for Managing High Blood Pressure and High Cholesterol in Health Care Settings: A Qualitative Case Study

    Victoria V. Anwuri, MPH

    2008-07-01

    Full Text Available IntroductionPolicy, environmental, and systems-level interventions are part of a comprehensive approach to managing high blood pressure and high cholesterol, which are key risk factors for heart disease and stroke. In this qualitative case study, we identified clinical practices in health care organizations that used policy, environmental, or systems-level interventions to improve patient outcomes for these conditions. Our 4 objectives were to describe 1 policy, environmental, and systems-level interventions; 2 enabling factors and barriers that affected implementation; 3 methods for evaluating the success of the intervention; and 4 lessons learned from the health care practices that implemented these interventions.MethodsThrough literature review and expert guidance, we identified 34 health care practices that used policy, environmental, and systems-level interventions to manage high blood pressure and high cholesterol. In 2003, we conducted case study interviews with key informants for 9 health care practices that 1 demonstrated improved patient outcomes for blood pressure or cholesterol; 2 implemented the interventions for at least 1 year; and 3 remained committed to sustaining or institutionalizing interventions. We taped and transcribed the interviews and used Centers for Disease Control and Prevention EZ-Text software (www.cdc.gov/hiv/software/ez-text.htm to code, categorize, and analyze the responses.ResultsThe health care practices we studied implemented specialized lipid clinics, disease management programs, physician reminder systems, and participation in the Health Resources and Services Administration’s Bureau of Primary Care Health Disparities Collaboratives. All practices used comprehensive systems for patient care that were well-defined, measurable, and linked to desirable patient outcomes. Most relied on data systems to identify patients targeted for the interventions and practice areas that needed improvement, and to track the

  5. Cord Blood

    Saeed Abroun

    2014-05-01

    Full Text Available   Stem cells are naïve or master cells. This means they can transform into special 200 cell types as needed by body, and each of these cells has just one function. Stem cells are found in many parts of the human body, although some sources have richer concentrations than others. Some excellent sources of stem cells, such as bone marrow, peripheral blood, cord blood, other tissue stem cells and human embryos, which last one are controversial and their use can be illegal in some countries. Cord blood is a sample of blood taken from a newborn baby's umbilical cord. It is a rich source of stem cells, umbilical cord blood and tissue are collected from material that normally has no use following a child’s birth. Umbilical cord blood and tissue cells are rich sources of stem cells, which have been used in the treatment of over 80 diseases including leukemia, lymphoma and anemia as bone marrow stem cell potency.  The most common disease category has been leukemia. The next largest group is inherited diseases. Patients with lymphoma, myelodysplasia and severe aplastic anemia have also been successfully transplanted with cord blood. Cord blood is obtained by syringing out the placenta through the umbilical cord at the time of childbirth, after the cord has been detached from the newborn. Collecting stem cells from umbilical blood and tissue is ethical, pain-free, safe and simple. When they are needed to treat your child later in life, there will be no rejection or incompatibility issues, as the procedure will be using their own cells. In contrast, stem cells from donors do have these potential problems. By consider about cord blood potency, cord blood banks (familial or public were established. In IRAN, four cord blood banks has activity, Shariati BMT center cord blood bank, Royan familial cord blood banks, Royan public cord blood banks and Iranian Blood Transfusion Organ cord blood banks. Despite 50,000 sample which storage in these banks, but the

  6. Restrained cerebral hyperperfusion in response to superimposed acute hypoxemia in growth-restricted human fetuses with established brain-sparing blood flow.

    Fu, Jing; Olofsson, Per

    2006-01-01

    Objective: To investigate the cerebral circulatory response to superimposed acute hypoxemia in growth-restricted fetuses with established brain-sparing flow (BSF) during basal conditions. Material and methods: 76 term fetuses suspected of growth restriction were exposed to Doppler velocimetry in the umbitical artery (UA) and middle cerebral artery (MCA), and in 38-39 cases also in Galen's vein (GV), straight sinus (SS), and transverse sinus (TS), before and during an oxytocin challenge te...

  7. Establishing and evaluating bar-code technology in blood sampling system: a model based on human centered human-centered design method.

    Chou, Shin-Shang; Yan, Hsiu-Fang; Huang, Hsiu-Ya; Tseng, Kuan-Jui; Kuo, Shu-Chen

    2012-01-01

    This study intended to use a human-centered design study method to develop a bar-code technology in blood sampling process. By using the multilevel analysis to gather the information, the bar-code technology has been constructed to identify the patient's identification, simplify the work process, and prevent medical error rates. A Technology Acceptance Model questionnaire was developed to assess the effectiveness of system and the data of patient's identification and sample errors were collected daily. The average scores of 8 items users' perceived ease of use was 25.21(3.72), 9 items users' perceived usefulness was 28.53(5.00), and 14 items task-technology fit was 52.24(7.09), the rate of patient identification error and samples with order cancelled were down to zero, however, new errors were generated after the new system deployed; which were the position of barcode stickers on the sample tubes. Overall, more than half of nurses (62.5%) were willing to use the new system. PMID:24199057

  8. ACL-TOP700血凝仪凝血4项正常参考区间的建立%Establishment of normal reference interval for four items of blood coagulation on ACL-TOP Automatic coagulation analyzer

    陈锐; 鲁燕飞; 周志兰; 姚振国; 陈国强

    2015-01-01

    Objective To establish normal reference interval for four items of blood coagulation on ACL‐TOP Automatic coagu‐lation analyzer .Methods The fasting anti‐coagulation blood samples were collected from 1 268 inpatients and people conducted physical examination ,all subjects without liver disease ,history of blood disease and coagulation disfunction .The prothrombin time (PT) ,activated partical prothrombin time(APTT) ,thrombin time(TT) and serum levels of fibrinogen(FIB) were determined by u‐sing ACL‐TOP automatic coagulation analyzer which was producted by America IL company .And data of determination results were used to establish the normal reference intervals of indexes in this laboratory .Results The precision and accuracy of this analy‐zer was good .There were differences of normal reference intervals between which established in this laboratory and which provided by the manufacturer .Conclusion Each laboratory should establish its own normal reference interval ,not blindly refer to reference interval provided by regents manual .%目的:建立ACL‐TOP700全自动血凝分析仪本实验室凝血4项的正常参考区间。方法筛选1268住院患者及门诊体检者,均无肝病、血液病史及出凝血功能障碍,空腹采集其静脉抗凝血。采用美国IL公司生产的ACL‐TOP700全自动血凝分析仪进行凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)测定,建立本实验室 PT、APTT、TT、FIB的正常参考区间。结果该仪器精密度、正确度均良好,各参考区间与厂家提供的参考区间有一定的差异。结论各个实验室应建立自己的参考区间,不可盲目引用厂家试剂说明书上提供的正常参考区间。

  9. 建立POCT血糖检测质量管理体系的实践与思考%Practice and reflection on establishing the quality management system of POCT blood glucose measurement

    马钰香; 张莉; 顾民; 马建锋; 陈妍; 吴建国

    2014-01-01

    使用便携式血糖仪可实现对患者血糖水平的随时监测,为临床医师制定和调整治疗方案提供了客观依据。POCT血糖检测的优势和局限都很明显,其检测质量直接影响着临床诊疗质量,医院对POCT血糖检测的质量管理尚有许多困难,探索建立血糖检测质量管理体系,旨在保证血糖检测结果的准确和可靠,同时为其它即时检验项目的质量管理提供借鉴和启示。%The blood glucose levels of patients can be monitored at any time by using a portable blood glucose meter, which provides an objective basis for developing and adjusting the treatment plan for clinicians. The advantages and limitations of POCT glucose measurement are obvious, and the detection quality directly influences the quality of clinical diagnosis and treatment. In addition, hospitals still encounter many difficulties in quality management of POCT glucose measurement. The exploration and establishment of quality management system aim to ensure the accuracy and reliability of blood glucose test results, as well as to provide reference and inspiration for the quality management of other instant test projects.

  10. Patient and healthcare professional satisfaction with a new, high accuracy blood glucose meter with color range indicator and wireless connectivity.

    Katz, Laurence B; Grady, Mike; Stewart, Lorna; Cameron, Hilary

    2016-07-01

    Accurate self-monitoring of blood glucose is a key component of effective self-management of glycemic control. The OneTouch VerioFlex(™) (OTVF) blood glucose monitoring system (BGMS) was evaluated for accuracy in a clinical setting. Patients also used OTVF for a 1-wk trial period and reported their level of satisfaction with meter features. In a separate study, healthcare professionals used an on-line simulator of the BGMS and answered questions about its potential utility to their patients. OTVF was accurate over a wide glucose range and met lay user and system accuracy blood glucose standards described in ISO15197:2013 as well as the accuracy requirements to fulfill US FDA expectations for 510(k) clearance of BGMS. Patients and healthcare professionals felt the features of OTVF, which has the capability to connect wirelessly to mobile devices and interact wirelessly with diabetes management software, could provide significant benefits to them or their patients. PMID:27232211

  11. Blood Clots

    ... Index A-Z Blood Clots Blood clots are semi-solid masses of blood that can be stationary (thrombosis) ... treated? What are blood clots? Blood clots are semi-solid masses of blood. Normally, blood flows freely through ...

  12. Establishment and verification of blood cell analysis review criteria in women and children specialized hospital%妇儿专科医院血液分析复检规则的建立及验证

    王月芳; 江咏梅; 张鸽; 杜泽丽; 陈岚; 叶蕾; 陈琪

    2013-01-01

    目的 建立适合妇女儿童专科医院的血常规复检规则.方法 以“XE-2100血细胞分析复检标准制定协作组”制定的XE-2100血液分析仪复检规则为评估基础,根据妇女儿童专科医院自己独特的病种特点及儿童白细胞(WBC)分类存在生理性交叉现象完善相应规则.Sysmex XE-2100全自动血液分析仪检测1 120例标本,以涂片镜检为金标准,进行临床复检工作并进行规则优化.结果 初始复检规则复检率65.98%,根据妇儿医院特点,通过调整WBC、血小板(PLT)计数、WBC分类百分比进行第1次优化后,假阳性率40.71%;将未成熟粒细胞(IG)与WBC≥10×109/L组合、幼稚细胞(Blast)与WBC≤4×109/L或≥10×109/L组合、变异淋巴细胞(Atypical/Variant)与淋巴细胞(Lymph)%>50%组合进行第2次优化后,假阳性率为17.53%,假阴性率4.49%,造成假阴性的主要项目为Atypical/Variant Lymph(< 5%)、PLT >70×109/L,验证通过.最终制定出符合妇女儿童专科医院的专有复检规则.结论 血涂片复检规则在临床应用过程中,应注意收集、整理发现问题,及时根据自身医院特点对复检规则进行修改、完善,以提高血细胞分析质量和工作效率.%Objective To establish proper review criteria for blood cell analysis in women and children specialized hospital. Methods Based on the review criteria from the cooperation group of formulation for blood cell analysis by Sysmex XE-2100 hematology analyzer, as the women and children specialized hospital with the own unique disease characteristics and children white blood cell ( WBC ) physiological characteristics, the review criteria was optimized. The total 1120 samples were detected by Sysmex XE-2100 hematology analyzer, blood smear determination was as the golden standard, and the new review criteria was evaluated and optimized. Results The review rate of initial review criteria was 65.98%. According to the women and children

  13. Have You Given Blood Lately?

    ... testing: After donation, blood establishments are required to test each unit of donated blood for the following infectious disease agents: · Hepatitis B · Hepatitis C · Human immunodeficiency viruses (HIV) 1 and ...

  14. Blood pressure

    ... the walls of the arteries is called blood pressure. Blood pressure is measured both as the heart contracts, which ... as it relaxes, which is called diastole. Normal blood pressure is considered to be a systolic blood pressure ...

  15. Blood transfusions

    ... this page: //medlineplus.gov/ency/patientinstructions/000431.htm Blood transfusions To use the sharing features on this ... several sources of blood which are described below. Blood From the Public (Volunteer Blood Donation) The most ...

  16. Blood Basics

    ... Patient Group Links Advocacy Toolkit Home For Patients Blood Basics Blood is a specialized body fluid. It ... about 9 pints. Jump To: The Components of Blood and Their Importance Many people have undergone blood ...

  17. Blood Thinners

    If you have some kinds of heart or blood vessel disease, or if you have poor blood flow to your brain, your doctor may recommend that you take a blood thinner. Blood thinners reduce the risk of heart ...

  18. Blood culture

    Culture - blood ... A blood sample is needed . The site where blood will be drawn is first cleaned with an antiseptic such ... organism from the skin getting into (contaminating) the blood sample and causing a false-positive result (see ...

  19. Blood Types

    ... How Can I Help a Friend Who Cuts? Blood Types KidsHealth > For Teens > Blood Types Print A A ... or straight hair instead of curly. ...Make Eight Blood Types The different markers that can be found in ...

  20. Blood Types

    ... confidence to respond in emergency situations with the skills that can help to save a life. Learn more » Red Cross Information Donating Blood Learn About Blood Hosting a Blood Drive For Hospitals Engage with Us About Us Media ...

  1. Immunoelectrophoresis - blood

    IEP - serum; Immunoglobulin electrophoresis - blood; Gamma globulin electrophoresis; Serum immunoglobulin electrophoresis ... A blood sample is needed. For information on how this is done, see: Venipuncture

  2. 76 FR 50230 - Center for Devices and Radiological Health 510(k) Clearance Process; Recommendations Proposed in...

    2011-08-12

    ... August 5, 2010 (75 FR 47307). After reviewing public comment, CDRH issued a plan of action for.... Comments: Regardless of attendance at the public meeting, interested persons may submit either electronic... adequate information to inform the design of a new medical device regulatory framework for class II...

  3. 78 FR 69693 - Draft Guidance for Industry: Recommendations for Premarket Notification (510(k)) Submissions for...

    2013-11-20

    ... the draft guidance to the Office of Communication, Outreach and Development (HFM- 40), Center for... Research (HFM-17), Food and Drug Administration, 1401 Rockville Pike, Suite 200N, Rockville, MD...

  4. 75 FR 4402 - Strengthening the Center for Devices and Radiological Health's 510(k) Review Process; Public...

    2010-01-27

    ... will include no more than 10 non-FDA participants. Only one participant from an organization or company... substantial equivalence to the device's predicate(s)? If these documents are not sufficient, please describe... controls, and which risks are sufficient to make the device ineligible for de novo classification? 3. If...

  5. Fully portable blood irradiator

    A fully portable blood irradiator was developed using the beta emitter thulium-170 as the radiation source and vitreous carbon as the body of the irradiator, matrix for isotope encapsulation, and blood interface material. These units were placed in exteriorized arteriovenous shunts in goats, sheep, and dogs and the effects on circulating lymphocytes and on skin allograft retention times measured. The present work extends these studies by establishing baseline data for skin graft rejection times in untreated animals

  6. Artificial blood

    Sarkar Suman

    2008-01-01

    Full Text Available Artificial blood is a product made to act as a substitute for red blood cells. While true blood serves many different functions, artificial blood is designed for the sole purpose of transporting oxygen and carbon dioxide throughout the body. Depending on the type of artificial blood, it can be produced in different ways using synthetic production, chemical isolation, or recombinant biochemical technology. Development of the first blood substitutes dates back to the early 1600s, and the search for the ideal blood substitute continues. Various manufacturers have products in clinical trials; however, no truly safe and effective artificial blood product is currently marketed. It is anticipated that when an artificial blood product is available, it will have annual sales of over $7.6 billion in the United States alone.

  7. Blood smear

    ... osmotic fragility ) Deficiency of an enzyme called lecithin cholesterol acyl transferase Abnormalities of hemoglobin , the protein in ... sickle and Pappenheimer Red blood cells, target cells Formed elements of blood References Bain BJ. The peripheral ...

  8. 8岁以下儿童末梢血血红蛋白参考范围分析%Establishment of Reference Intervals for Peripheral Blood Hemoglobin Aiming at Children below 8 Years Old

    梁有勇

    2012-01-01

    目的 建立≤8岁儿童末梢血血红蛋白的参考范围.方法 选择2010年5月-2011年10月在我院健康体检的≤8岁儿童1 514例,按年龄分组:3~12个月组429例,1~3岁组462例,4~8岁组623例.均经体检证明生长、发育正常,无慢性病史,无血红蛋白疾病史和贫血史,无血吸虫、钩虫、疟疾等寄生虫感染的贫血,无蚕豆病.检查前未接受过铁剂和输血治疗.结果 1 514个血红蛋白测定值,偏度系数为0.401,峰度系数为-0.117,呈近似正态分布.3~12个月组、1~3岁组、4~8岁组男童、女童及男女合计血红蛋白水平比较差异均有统计学意义(P<0.05).3~12个月儿童血红蛋白参考范围为96~125 g/L,1~3岁儿童血红蛋白参考范围为100~129 g/L,4~8岁男童血红蛋白参考范围为101~137 g/L,4~8岁女童血红蛋白参考范围为103~131 g/L.结论 不同年龄段应采用不同的血红蛋白参考范围,不同实验室应建立适合自己的血红蛋白的参考范围.%Objective To determine the reference intervals for hemoglobin of peripheral blood aiming at children below 8 years old. Methods We selected 1 514 healthy children below 8, inclusive who came to our hospital for physical check -up from May 2010 to October 2011 and according to their ages divided them into three groups : 3 ~ 12 months group 429 cases, 1 ~ 3 year olds group 462 cases, 4 ~ 8 years old group 623 cases. All the subjects underwent physical examination and were con -firmed normal in their growth and development , without any chronic disease , hemoglobin disease , anemia, favism and anemia caused by schistosomiasis , hookworm, malaria and they didn 't receive iron supplements or any kind of transfusion therapy. Re-sults All subjects' hemoglobin level was approximately positively distributed with coefficient of skewness being 0. 401 and coeffi-cient of kurtosis being -0. 117. The differences between males , females, males and females together in the three

  9. Technical efficiency of blood component preparation in blood centres of 10 European countries

    Veihola, Marketta

    2008-01-01

    Various reasons, such as ethical issues in maintaining blood resources, growing costs, and strict requirements for safe blood, have increased the pressure for efficient use of resources in blood banking. The competence of blood establishments can be characterized by their ability to predict the volume of blood collection to be able to provide cellular blood components in a timely manner as dictated by hospital demand. The stochastically varying clinical need for platelets (PLTs) sets a specif...

  10. Blood / Money

    Strong, Thomas

    1997-01-01

    Marilyn Strathern has argued that "nature" in Euro-American culture has appeared as constraint; it has figured the givens of existence on which human artifice is seen to construct "society" or "culture."(5) Among those givens is the notion that human beings are naturally individuals. And blood, too, images individuality: "The very thought of blood, individual blood, touches the deepest feelings in man about life and death" ([RIchard Titmuss] 16.) Transfusion medicine, then, draws on a series ...

  11. 21 CFR 864.9700 - Blood storage refrigerator and blood storage freezer.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Blood storage refrigerator and blood storage freezer. 864.9700 Section 864.9700 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood...

  12. Understanding Blood Counts

    ... Lab and Imaging Tests Understanding Blood Counts Understanding Blood Counts Understanding Blood Counts SHARE: Print Glossary Blood cell counts give ... your blood that's occupied by red cells. Normal Blood Counts Normal blood counts fall within a range ...

  13. Blood donation

    GS Department

    2009-01-01

    A blood donation is organised by the Cantonal Hospital of Geneva On Thursday 19 March 2009 from 9 a.m. to 5 p.m. CERN RESTAURANT 2 Number of donations during the last blood donations :135 donors in July 2008 122 donors in November 2008 Let’s do better in 2009 !!! Give 30 minutes of your time to save lives...

  14. BLOOD DONATION

    SC Unit

    2008-01-01

    A blood donation, organized by EFS (Etablissement Français du Sang) of Annemasse will take place On Wednesday 12 November 2008, from 8:30 to 16:00, at CERN Restaurant 2 If possible, please, bring your blood group Card.

  15. Tainted blood

    Deleuran, Ida; Sheikh, Zainab Afshan; Hoeyer, Klaus

    2015-01-01

    study of the historical rise and current workings of safety practices in the Danish blood system. Here, we identify a strong focus on contamination in order to avoid 'tainted blood', at the expense of working with risks that could be avoided through enhanced blood monitoring practices. Of further...... significance to this focus are the social dynamics found at the heart of safety practices aimed at avoiding contamination. We argue that such dynamics need more attention, in order to achieve good health outcomes in transfusion medicine. Thus, we conclude that, to ensure continuously safe blood systems, we...... need to move beyond the bifurcation of the social and medical aspects of blood supply as two separate issues and approach social dynamics as key medical safety questions....

  16. Establishment Registration & Device Listing

    U.S. Department of Health & Human Services — This searchable database contains establishments (engaged in the manufacture, preparation, propagation, compounding, assembly, or processing of medical devices...

  17. Quality Management, Quality Assurance and Quality Control in Blood Establishments

    Bolbate, N

    2008-01-01

    Quality terms and the roots of the matter are analyzed according to European Committee’s recommendations. Essence of process and product quality control as well as essence of quality assurance is described. Quality system’s structure including quality control, quality assurance and management is justified in the article.

  18. Donating Blood

    ... And be sure to drink plenty of water, milk, or other liquids. Before donating, you'll need to answer some questions about your medical history, and have your temperature, pulse, blood pressure, and ...

  19. Blood smear

    ... of RBCs due to body destroying them ( immune hemolytic anemia ) Low number of RBCs due to some red ... of Heinz bodies may indicate: Alpha thalassemia Congenital hemolytic anemia Disorder in which red blood cells break down ...

  20. Amylase - blood

    Amylase is an enzyme that helps digest carbohydrates. It is made in the pancreas and the glands ... saliva. When the pancreas is diseased or inflamed, amylase releases into the blood. A test can be ...

  1. Moving blood.

    Pelis, K

    1997-01-01

    Our internationally acclaimed journalist Sanguinia has returned safely from her historic assignment. Travelling from Homeric Greece to British Romanticism, she was witness to blood drinking, letting, bathing, and transfusion. In this report, she explores connections between the symbolic and the sadistic; the mythic and the medical--all in an effort to appreciate the layered meanings our culture has given to the movement of blood between our bodies. PMID:9407636

  2. Blood Clotting and Pregnancy

    Full Text Available ... Blood Basics Blood Disorders Anemia Bleeding Disorders Blood Cancers Blood Clots Blood Clotting and Pregnancy Clots and ... Increased maternal age Other medical illness (e.g., cancer, infection) back to top How are Blood Clots ...

  3. Biology of Blood

    ... Mail Facebook TwitterTitle Google+ LinkedIn Home Blood Disorders Biology of Blood Overview of Blood Medical Dictionary Also ... Version. DOCTORS: Click here for the Professional Version Biology of Blood Overview of Blood Components of Blood ...

  4. Blood (For Parents)

    ... Story" 5 Things to Know About Zika & Pregnancy Blood KidsHealth > For Parents > Blood Print A A A ... about the mysterious, life-sustaining fluid called blood. Blood Basics Two types of blood vessels carry blood ...

  5. Blood Facts and Statistics

    ... About Blood > Blood Facts and Statistics Printable Version Blood Facts and Statistics Facts about blood needs Facts ... about American Red Cross Blood Services Facts about blood needs Every two seconds someone in the U.S. ...

  6. Catecholamine blood test

    Norepinephrine -- blood; Epinephrine -- blood; Adrenalin -- blood; Dopamine -- blood ... A blood sample is needed. ... the test. This is especially true if both blood and urine catecholamines are to be measured. You ...

  7. Establishment of WTGs

    This paper briefly outlines the reasons for establishing a wind turbine generator and the consequent disadvantages. Consideration is then given to the determining factors affecting the economics of wind turbine generators with special reference to Denmark. (UK)

  8. AN INDIAN ENTREPRENEUR ESTABLISHING

    Vaghela, Amit; Wang, Xiaoran

    2008-01-01

    Title: An Indian Entrepreneur Establishing Business in Europe Course: Master Thesis EFO705 in International Business and Entrepreneurship, Swedish credit points (15 ECTS) Authors: Xiaoran Wang and Amit Vaghela Tutor: Leif Linnskog Problem: How did Mr. Deepak Soni establish and develop his company Anora Pvt Ltd in Poland, a company operating in the branch of textile and clothing? From this research problem, the dissertation will be focused on the internationalization. Purpose: The aim of thesi...

  9. AUDIT OF BLOOD REQUISITION.

    Deb, P; Swarup, D; Singh, M M

    2001-01-01

    A total of 2793 requisition forms received by the blood banks of a Service zonal hospital, between June 1995 and December 1999, were analysed. 1697 (60.71%) forms were demand for single unit blood. Blood was collected against only 1099 forms (39.34%) out of which 713 (64.88%) were single unit issue. Urgency of requirement and blood group of patients was omitted in 56% cases. 104 forms were received without mention of the indications for transfusion. History of previous transfusion and pregnancy/HDN were omitted in 25.1% and 37.38% cases respectively. At an average 14.61% of the total collection was discarded. Of the 292 units discarded, 242 units were due to non utilisation. A transfusion committee should be established in all hospitals with a licensed blood bank. It should constitute definite objectives and conduct regular audits (prospective audit, concurrent review or retrospective review), in order to achieve utmost efficiency and numerous benefits, in terms of workload, cost, errors, risks of transfusion and ultimately increased customer satisfaction. It should strive to abolish single unit and inappropriate transfusion, and advocate autologous transfusion. PMID:27365575

  10. [Which place for physicians in blood supply?].

    Danic, B; Pelletier, B

    2013-05-01

    Historically, blood transfusion has been divised, enhanced and organized by physicians. The special status of blood led to ensure that collection of blood and its components were placed under the supervision of a physician. Throughout its history, blood transfusion organization in France has established an exclusive exercise of the collection of blood and its components entrusted to doctors, thus creating the concept of "medicine of donation". This view is changing, and programmed exercise of this activity by nurses led to question about this profession perimeter, its necessary evolution, and finally about the place of physicians in blood supply. PMID:23537956

  11. Blood Transfusion

    ... to infections including those we develop from our vaccinations (such as poliovirus antibodies, which are made by ... the Transfusion Medicine Unit, Blood Bank, and Stem Cell Storage Facility University of Rochester Medical ... and health educators who are available by phone Monday through Friday, 9 am to 9 pm ( ...

  12. Rare blood donors with irregular antibodies

    Krga-Milanović Mirjana

    2013-01-01

    Full Text Available Introduction. Blood groups are inherited biological characteristics that do not change throughout life in healthy people. Blood groups represent antigens found on the surface of red blood cells. Kell blood group system consists of 31 antigens. Kell antigen (K is present in 0.2% of the population (the rare blood group. Cellano antigen is present in more than 99% (the high-frequency antigen. These antigens have a distinct ability to cause an immune response in the people after blood transfusion or pregnancy who, otherwise, did not have them before. Case Report. This paper presents a blood donor with a rare blood group, who was found to have an irregular antibody against red blood cells by indirect antiglobulin test. Further testing determined the specificity of antibody to be anti-Cellano. The detected antibody was found in high titers (1024 with erythrocyte phenotype Kell-Cellano+. The blood donor was found to have a rare blood group KellKell. This donor was excluded from further blood donation. It is difficult to find compatible blood for a person who has developed an antibody to the high-frequency antigen. The donor’s family members were tested and Cellano antigen was detected in her husband and child. A potential blood donor was not found among the family members. There was only one blood donor in the Register of blood donors who was compatible in the ABO and Kell blood group system. Conclusion. For the successful management of blood transfusion it is necessary to establish a unified national register of donors of rare blood groups and cooperate with the International Blood Group Reference Laboratory in Bristol with the database that registers donors of rare blood groups from around the world.

  13. Secular Religious Establishment

    Lægaard, Sune

    2013-01-01

    Secularism as a political doctrine claims that religion and politics should be separated. The compatibility question is whether secularism can accept some forms of religious establishment in the form of institutional linkages between state and organised religion. I argue that the answer to the co...

  14. Establishing a robotics program.

    Steers, William D; LeBeau, Sam; Cardella, Joseph; Fulmer, Brant

    2004-11-01

    Establishing a successful robotics program requires consideration of several issues, including the surgical procedures to be performed, training and personnel, facilities, finance, and marketing. This article considers these factors from an academic health center standpoint and evaluates the benefits and risks of this new technology for urology departments. PMID:15474605

  15. Blood Culture (For Parents)

    ... KidsHealth in the Classroom What Other Parents Are Reading Upsetting News Reports? What to Say Vaccines: Which ... BMP) Blood Test: Complete Blood Count Basic Blood Chemistry Tests Getting a Blood Test (Video) Blood Test: ...

  16. High Blood Pressure (Hypertension)

    ... your doctor prescribes it, medicine. What Is Blood Pressure? Blood pressure is the force of blood flow inside ... Will I Know if I Have High Blood Pressure? High blood pressure is a silent problem — you won't ...

  17. Blood Pressure Quiz

    ... page please turn Javascript on. Feature: High Blood Pressure Blood Pressure Quiz Past Issues / Fall 2011 Table of Contents ... About High Blood Pressure / Treatment: Types of Blood Pressure Medications / Blood Pressure Quiz Fall 2011 Issue: Volume 6 Number ...

  18. Hypertension (High Blood Pressure)

    ... right away. continue How Do Doctors Measure Blood Pressure? Blood pressure readings are fast and painless. Blood pressure ... same age, height, and gender have lower blood pressure. Blood pressure between 90% and 95% of the normal ...

  19. Blood pressure measurement

    Diastolic blood pressure; Systolic blood pressure; Blood pressure reading; Measuring blood pressure ... or your health care provider will wrap the blood pressure cuff snugly around your upper arm. The ...

  20. Blood Transfusions (For Teens)

    ... How Can I Help a Friend Who Cuts? Blood Transfusions KidsHealth > For Teens > Blood Transfusions Print A ... United States get blood transfusions. A Bit About Blood As blood moves throughout the body, it carries ...

  1. Blood Count Tests

    Your blood contains red blood cells (RBC), white blood cells (WBC), and platelets. Blood count tests measure the number and types of cells in your blood. This helps doctors check on your overall health. ...

  2. Blood Clotting and Pregnancy

    Full Text Available ... About Awards Membership ASH Foundation Global Programs Newsroom facebook twitter youtube linkedin Research In This Section Agenda ... View all publications For Patients Blood Basics Blood Disorders Anemia Bleeding Disorders Blood Cancers Blood Clots Blood ...

  3. Blood Clotting and Pregnancy

    Full Text Available ... For Patients Blood Disorders Blood Clots Blood Clotting & Pregnancy If you are pregnant, or you have just ... The risk of developing a blood clot during pregnancy is increased by the following: Previous blood clots ...

  4. Bacterial contamination of blood components.

    Seghatchian, J

    2001-10-01

    Despite considerable advances in the safety of blood components, transfusion associated bacterial infection (TABI) remains an unresolved problem. As yet there are no perfect preventative, screening and/or detection methodologies for eliminating contaminated units. Until a practical, rapid, cost-effective and logistically acceptable test becomes available, we should be satisfied with the choice of various limited solutions that at least partially improve the bacterial safety of blood components. It is also necessary to establish standardised guidelines and agreed upon systematic procedures for the recognition and reporting of the laboratory and clinical evaluation of adverse reactions in recipients of contaminated blood components. PMID:11761277

  5. Establishment of Intestinal Bacteriology

    Mitsuoka, Tomotari

    2014-01-01

    Research on intestinal bacteria began around the end of the 19th century. During the last 5 decades of the 20th century, research on the intestinal microbiota made rapid progress. At first, in my work, I first developed a method of comprehensive analysis of the intestinal microbiota, and then I established classification and identification methods for intestinal anaerobes. Using these methods I discovered a number of ecological rules governing the intestinal microbiota and the role of the int...

  6. Managing your blood sugar

    Hyperglycemia - control; Hypoglycemia - control; Diabetes - blood sugar control ... Know how to: Recognize and treat low blood sugar (hypoglycemia) Recognize and treat high blood sugar (hyperglycemia) ...

  7. Establishing effective working relationships.

    Houghton, Trish

    2016-02-24

    This article, the second in a series of 11, provides support and offers advice to new and existing mentors and practice teachers to enable them to progress in their role and develop a portfolio of evidence. In particular, the article discusses how to establish effective working relationships and emphasises the importance of the student-mentor or student-practice teacher relationship. It examines the essential qualities, attributes and characteristics of an effective mentor or practice teacher. The article provides learning activities and suggests ways in which mentors and practice teachers can undertake various self-assessments, enabling them to gather relevant evidence to demonstrate how they can meet and maintain the requirements for these roles as stipulated by the Nursing and Midwifery Council. PMID:26907148

  8. 78 FR 14097 - Pulse Oximeters-Premarket Notification Submissions [510(k)s]; Guidance for Industry and Food and...

    2013-03-04

    ... Federal Register of July 19, 2007 (72 FR 39631), FDA announced the availability of the draft guidance... HUMAN SERVICES Food and Drug Administration Pulse Oximeters--Premarket Notification Submissions... availability of the guidance entitled ``Pulse Oximeters--Premarket Notification Submissions .'' This...

  9. 76 FR 44935 - Draft Guidance for Industry and Food and Drug Administration Staff; 510(k) Device Modifications...

    2011-07-27

    ... the Utilization of Science in Regulatory Decision Making Preliminary Report and Recommendations... Manufacturers, International, and Consumer Assistance, Center for Devices and Radiological Health, Food and Drug... legally marketed device. This draft guidance is not final nor is it in effect at this time....

  10. 76 FR 81510 - Draft Guidance for Industry and Food and Drug Administration Staff; the 510(k) Program...

    2011-12-28

    ... Communication, Outreach and Development (HFM-40), Center for Biologics Evaluation and Research (CBER), Food and...) Paradigm Guidance. FDA recognizes and supports efforts for global convergence of regulatory systems, and...

  11. Blood Clotting and Pregnancy

    Full Text Available ... 6, 2016, San Diego, CA Abstracts Registration Housing Travel Information Government Concierge View all meetings Publications Blood ... Blood Clots Blood Clotting and Pregnancy Clots and Travel DVT Myths vs. Facts Blood Detectives Find a ...

  12. Types of Blood Donations

    ... Double Red Cell Plasma Platelets Red Cells What blood donation type is best for me? **If you do not ... blood type, a whole blood donation is recommended** Blood Donation Types: Volunteer Donations The standard or most common type ...

  13. Blood Type Game

    ... Donor Community > Games > Blood Type Game Printable Version Blood Type Game This feature requires version 6 or later ... many points as possible by matching the appropriate blood type of a donor to the blood type of ...

  14. Understanding Blood Pressure Readings

    ... What is the AHA recommendation for healthy blood pressure? This blood pressure chart reflects categories defined by the American ... unusually low blood pressure readings. How is high blood pressure diagnosed? Your healthcare providers will want to get ...

  15. Blood Clotting and Pregnancy

    Full Text Available ... Research Programs and Awards View all Blood Current Issue First Edition Abstracts Collections Submit to Blood View ... Government Concierge View all meetings Publications Blood Current Issue First Edition Abstracts Blood: How I Treat A ...

  16. High Blood Pressure

    ... Connected Home » High Blood Pressure Heath and Aging High Blood Pressure What Is Blood Pressure? Do ... high blood pressure increases as you get older. Gender. Before age 55, men have a greater chance ...

  17. Blood donation before surgery

    ... this page: //medlineplus.gov/ency/patientinstructions/000367.htm Blood donation before surgery To use the sharing features ... vessels. Several sources of blood are described here. Blood From the Public (Volunteer Blood Donation) The most ...

  18. Blood Transfusion (For Parents)

    ... Story" 5 Things to Know About Zika & Pregnancy Blood Transfusions KidsHealth > For Parents > Blood Transfusions Print A ... and help put your child at ease. About Blood Transfusions Blood is like the body's transportation system. ...

  19. Blood donation before surgery

    ... choose to use a method called autologous blood donation. Autologous blood is blood donated by you, which you later receive if you need a transfusion during or after surgery. You can have blood ...

  20. High blood pressure

    ... you are at risk for: Bleeding from the aorta, the large blood vessel that supplies blood to ... tests Blood pressure check Blood pressure References American Diabetes Association. Standards of medical care in diabetes-2015 ...

  1. Blood Clotting and Pregnancy

    Full Text Available ... raise public awareness of these blood conditions and increase research on the causes, prevention, and treatment. Blood ... of developing a blood clot during pregnancy is increased by the following: Previous blood clots A genetic ...

  2. Blood Clotting and Pregnancy

    Full Text Available ... Housing Travel Information Government Concierge View all meetings Publications Blood Current Issue First Edition Abstracts Blood Advances ... reflect the most recent scientific research View all publications For Patients Blood Basics Blood Disorders Anemia Bleeding ...

  3. Blood safety in the world updated

    Silvano Wandel

    2010-01-01

    @@ Blood safety is of paramount importance in any medical context, given that it represents one of the most impor-tant supportive procedures in medicine. Nearly all medical fields that lead with very critical patients will depend on blood products as part of supporting medical strategies (both clinical and surgical). Thus, it is im-portant that every country in the world relies on a well established national blood program.

  4. Types of Blood Transfusions

    ... Home » Health Information for the Public » Health Topics » Blood Transfusion » Types of Blood Transfusions Explore Blood Transfusion What Is... ... Share this page from the NHLBI on Twitter. Types of Blood Transfusions Blood is transfused either as whole blood ( ...

  5. Cord blood testing

    ... to evaluate the oxygen, carbon dioxide, and pH levels) Blood sugar level Blood type and Rh Complete blood count ( ... means you have a blood infection (septicemia). High levels of blood sugar (glucose) in the cord blood may be found ...

  6. Blood and Diversity

    ... The Process Risks and Complications History of Blood Transfusion Iron and Blood Donation Iron Info. for All Donors Iron Info. for ... Donation Student Donors Donation Process Eligibility Blood FAQs Blood Donor ... of Blood Transfusion Hosting a Blood Drive What to Expect Hosting ...

  7. Autologous blood donation

    Goodnough, Lawrence T

    2004-01-01

    Although preoperative autologous blood donation is employed in elective surgery, this is declining because of the increasingly safe allogeneic blood supply. However, it continues to be used because of the public's perception of allogeneic blood risks and increasing blood shortages. Patients may donate a unit of blood (450 ± 45 ml) as often as twice weekly, up to 72 hours before surgery. Preoperative autologous blood is most beneficial in procedures that cause significant blood loss. It has be...

  8. 21 CFR 864.9160 - Blood group substances of nonhuman origin for in vitro diagnostic use.

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Blood group substances of nonhuman origin for in... Used In Establishments That Manufacture Blood and Blood Products § 864.9160 Blood group substances of nonhuman origin for in vitro diagnostic use. (a) Identification. Blood group substances of nonhuman...

  9. Medications and Blood Pressure

    ... Blood Pressure Tools & Resources Stroke More Medications and Blood Pressure Updated:Jul 6,2016 When your blood pressure ... was last reviewed on 08/04/2014. High Blood Pressure • Home • About High Blood Pressure (HBP) • Why HBP ...

  10. Alternatives to Blood Transfusion

    ... saved articles window. My Saved Articles » My ACS » Blood Transfusion and Donation + - Text Size Download Printable Version [PDF] » TOPICS Document ... Possible risks of blood transfusions Alternatives to blood transfusions Donating blood Blood donation by cancer survivors To learn more References Previous ...

  11. Drug Establishments Current Registration Site

    U.S. Department of Health & Human Services — The Drug Establishments Current Registration Site (DECRS) is a database of current information submitted by drug firms to register establishments (facilities) which...

  12. [Blood transfusion and supply chain management safety].

    Quaranta, Jean-François; Caldani, Cyril; Cabaud, Jean-Jacques; Chavarin, Patricia; Rochette-Eribon, Sandrine

    2015-02-01

    The level of safety attained in blood transfusion now makes this a discipline better managed care activities. This was achieved both by scientific advances and policy decisions regulating and supervising the activity, as well as by the quality system, which we recall that affects the entire organizational structure, responsibilities, procedures, processes and resources in place to achieve quality management. So, an effective quality system provides a framework within which activities are established, performed in a quality-focused way and continuously monitored to improve outcomes. This system quality has to irrigate all the actors of the transfusion, just as much the establishments of blood transfusion than the health establishments. PMID:25578550

  13. High Blood Pressure

    ... normal blood pressure 140/90 or higher is high blood pressure Between 120 and 139 for the top number, ... prehypertension. Prehypertension means you may end up with high blood pressure, unless you take steps to prevent it. High ...

  14. Postpartum Blood Clots

    ... Infection Postpartum Blood Clots Postpartum Thyroid Disorders Postpartum Depression The risk of developing blood clots (thrombophlebitis) is increased for about 6 to 8 weeks after delivery (see Thromboembolic Disorders During Pregnancy ). Typically, blood clots occur in the deep veins ...

  15. Blood Type Puzzle.

    Kelly, Janet

    1997-01-01

    Presents a blood type puzzle that provides a visual, hands-on mechanism by which students can examine blood group reactions. Offers students an opportunity to construct their own knowledge about blood types. (JRH)

  16. High blood pressure - infants

    National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics . ...

  17. Low Blood Glucose (Hypoglycemia)

    ... Other Dental Problems Diabetic Eye Disease Low Blood Glucose (Hypoglycemia) What is hypoglycemia? Hypoglycemia, also called low ... actions can also help prevent hypoglycemia: Check blood glucose levels Knowing your blood glucose level can help ...

  18. What Is Blood?

    ... Our Member Blood Centers Our Partners What is blood? PUBLICATIONS EDUCATION PRESS ROOM BLOG CAREERS CONTACT ABC ... for patients who need it. One unit of blood can be separated into the following components: Nearly ...

  19. Ketones blood test

    ... Ketones - serum; Nitroprusside test; Ketone bodies - serum; Ketones - blood ... A blood sample is needed. ... When the needle is inserted to draw blood, some people feel slight ... there may be some throbbing or a slight bruise. This soon ...

  20. Magnesium blood test

    Magnesium - blood ... A blood sample is needed. ... When the needle is inserted to draw blood, some people feel slight pain. Others feel a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon ...

  1. High Blood Pressure Facts

    ... Heart Disease Cholesterol Salt Million Hearts® WISEWOMAN High Blood Pressure Facts Recommend on Facebook Tweet Share Compartir ... facts about high blood pressure [PDF-255K] . High Blood Pressure in the United States About 70 million ...

  2. Managing your blood sugar

    ... medlineplus.gov/ency/patientinstructions/000086.htm Managing your blood sugar To use the sharing features on this page, ... way your doctor or nurse recommends. Check your Blood Sugar Often Checking your blood sugar levels often and ...

  3. High blood sugar

    ... page: //medlineplus.gov/ency/patientinstructions/000332.htm High blood sugar To use the sharing features on this page, ... later when energy is needed. Symptoms of High Blood Sugar Symptoms of high blood sugar can include: Being ...

  4. Home blood sugar testing

    ... page: //medlineplus.gov/ency/patientinstructions/000324.htm Home blood sugar testing To use the sharing features on this ... with their nutrition and activity plans. Check Your Blood Sugar Often Usual times to test your blood sugar ...

  5. Hyperglycemia (High Blood Glucose)

    Full Text Available ... Blood Pressure Physical Activity High Blood Glucose My Health Advisor Tools To Know Your Risk Alert Day ... DKA (Ketoacidosis) & Ketones Kidney Disease (Nephropathy) Gastroparesis Mental Health Step On Up Treatment & Care Blood Glucose Testing ...

  6. Blood Clotting and Pregnancy

    Full Text Available ... back to top How are Blood Clots in Pregnant Women Treated? Typically, blood clots are treated with ... you think you have one. If you are pregnant and have concerns about blood clots, talk with ...

  7. Hyperglycemia (High Blood Glucose)

    Full Text Available ... symptoms include the following: High blood glucose High levels of sugar in the urine Frequent urination Increased ... you should check and what your blood glucose levels should be. Checking your blood and then treating ...

  8. High Blood Pressure

    ... pressure and should be taken seriously. Over time, consistently high blood pressure weakens and damages ... of landmark NIH blood pressure study confirm that lower blood pressure target can reduce ...

  9. Blood stain pattern analysis.

    Peschel, O; Kunz, S N; Rothschild, M A; Mützel, E

    2011-09-01

    Bloodstain pattern analysis (BPA) refers to the collection, categorization and interpretation of the shape and distribution of bloodstains connected with a crime. These kinds of stains occur in a considerable proportion of homicide cases. They offer extensive information and are an important part of a functional, medically and scientifically based reconstruction of a crime. The following groups of patterns can essentially be distinguished: dripped and splashed blood, projected blood, impact patterns, cast-off stains, expirated and transferred bloodstains. A highly qualified analysis can help to estimate facts concerning the location, quality and intensity of an external force. A sequence of events may be recognized, and detailed questions connected with the reconstruction of the crime might be answered. In some cases, BPA helps to distinguish between accident, homicide and suicide or to identify bloodstains originating from a perpetrator. BPA is based on systematic training, a visit to the crime scene or alternatively good photographic documentation, and an understanding and knowledge of autopsy findings or statements made by the perpetrator and/or victim. A BPA working group has been established within the German Society of Legal Medicine aiming to put the knowledge and practical applications of this subdiscipline of forensic science on a wider basis. PMID:21069481

  10. Blood Clotting and Pregnancy

    Full Text Available ... these blood conditions and increase research on the causes, prevention, and treatment. Blood clots are also potentially ... immobility (e.g., bedrest, long distance travel) ...

  11. 脑微血管内皮细胞与周细胞共培养构建体外血脑屏障模型%Establishment of an in vitro blood-brain harrier modal by coculturing brain microvascular endothelial cells and pericytes

    鹿文葆; 秦伟伟; 张秋菊; 李宏伟; 刘淑英; 修瑞娟

    2012-01-01

    目的 应用原代培养的大鼠脑微血管内皮细胞(brain microvascular endothelial cell,BMVEC)与脑周细胞共培养建立可模拟在体状态的稳定体外血脑屏障(blood-brain barrier,BBB)模型.方法 原代分离、纯化培养大鼠BMVEC和周细胞,通过免疫细胞化学染色方法鉴定分离的细胞,应用Transwell插槽(孔径0.4μm)共培养构建体外BBB模型,经4h渗漏试验、紧密连接蛋白鉴定、跨内皮电阻检测以及通透性试验评价其屏障功能,比较共培养模型与单纯BMVEC模型膜两侧电阻值差异以及对小分子荧光素钠(sodium fluorescein,Na-F)通透性的差异.结果 融合的BMVEC单层呈现典型的鹅卵石样外观,脑周细胞呈典型的不规则外形并具有重叠生长等特性.免疫双标法鉴定显示,脑周细胞阳性表达α-平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)和神经元-胶质抗原2(neuron-glial antigen2,NG2);共培养模型内皮细胞融合后,液面渗漏试验呈阳性;免疫细胞化学染色显示,内皮细胞间形成连续而致密的紧密连接;与BMVEC模型相比,共培养模型跨内皮细胞电阻[( 190.762±10.326)Ω/cm2对(96.503±8.012)Ω/cm2;t=- 24.489,P<0.01]显著增高,通透性显著降低(为单内皮模型的56.149% ±3.572%;t=19.330,P<0.01).结论 原代分离大鼠BMVEC 和周细胞共培养体外模型的形态、结构及屏障功能具备BBB的基本特征,为研究BBB提供了一种有用工具.%Objective To establish a stable in vitro model of blood-brain barrier (BBB) simulating in vivo state using the primary-cultured rat brain microvascular endothelial cells (BMVECs) and pericytes.Methods The primary rat BMVECs and pericytes were isolated,purified and cultured.The isolated cells were identified by immunocytochemical staining method.An in vitro model of BBB was constructed using Transwell inserts (pore size 0.4 μm) coculture.Its barrier function was evaluated by the 4-hour leakage test,tight junction

  12. Factors affecting forage stand establishment

    Sulc R.M.

    1998-01-01

    Significant advances have been made in our knowledge of forage seed physiology, technology, and stand establishment practices; however, stand establishment continues to be one of the most common production problems affecting forage crops in the USA. There is a need for research on stand establishment of forage crops under abiotic and biotic stress. Although the forage seed industry produces and markets seed of high quality, new methods of assessing seed vigor are needed and their use should b...

  13. Hyperglycemia (High Blood Glucose)

    Full Text Available ... how often you should check and what your blood glucose levels should be. Checking your blood and then treating ... I Treat Hyperglycemia? You can often lower your blood glucose level by exercising. However, if your blood glucose is ...

  14. BUN - blood test

    Blood urea nitrogen ... A blood sample is needed. Most of the time blood is drawn from a vein located on the inside ... Many medicines can interfere with blood test results. Your health ... if you need to stop taking any medicines before you have this ...

  15. Introduction to Iranian Blood Transfusion Organization and Blood Safety in Iran

    H Abolghasemi

    2009-03-01

    Full Text Available "nCurrently, in Iran blood transfusion is an integral part of the national health system and blood donation is voluntary and non­remu­nerated and blood and its components may not be a source of profit. In 1974 and following establishment of Iranian Blood Transfusion Organization (IBTO all blood transfusion activities from donor recruitment to production of blood com­po­nents and delivery of blood and blood products were centralized. The activities of IBTO are followed the laws and regu­la­tions of Ministry of Health and criteria of Iran National Regulatory Authority. In order to meet the country's demand in 2007 IBTO collected about 1.7 millions units of blood from the population of 70 millions. In 1979 coincided with the Is­lamic revolution the number of  blood units collected throughout the country were 124,000 units or 3.4 unit per 1000 popu­la­tion whereas after about 30 years this increased to about 25 unit per 1000 population. With improving the pool of vol­un­tary donors, IBTO has been successful in excluding "family replacement" donation since 2007 and reached to 100% volun­tary and nonremunerated blood donation. Currently more than 92% of blood donors in Iran are male and contribution of fe­male in blood donation is less than 8%. Although all donated blood in Iran screened for HBsAg since 1974, screening of blood units for HIV and HCV started since 1989 and 1996, respectively. The frequency of HBV infection in blood do­nors showed a significant decline from 1.79% in 1998 to 0.4% in 2007. The overall frequency of HCV and HIV infection are 0.13% and 0.004% respectively.

  16. 慢性心力衰竭心气虚兼血瘀水肿证大鼠模型的建立与整合判定%Establishment of Chronic Heart Failure Rat Model of Xin-qi Deficiency Complicated Blood Stasis and Edema Syndrome and Judgment of Diagnosis Information Integration

    林家茂; 郭伟星; 王营; 刘颖; 李亚茹; 李珩; 周杰

    2014-01-01

    血瘀水肿证的SD大鼠模型.%Objective To establish and evaluate chronic heart failure (CHF) rat model of Xin-qi deficiency complicated blood stasis and edema syndrome (XQD-BSES).Methods Totally 40 SD rats were randomly divided into the normal control group (Control),the propylthiouracil (PTU) group,the adriamycin (ADR),and the ADR + PTU group.Normal saline was used as equivalent solvent of each group.Rats in the Control group were intragastrically and intraperitoneally injected with normal saline.Rats in the PTU group were intragastrically injected with PTU suspension and intraperitoneally injected with normal saline.Rats in the ADR group were intragastrically injected with ADR solution and intraperitoneally injected with normal saline.And rats in the ADR + PTU group were intragastrically injected with PTU suspension and intraperitoneally injected with ADR solution.The dose of PTU was 0.2% of daily forage weight,once daily.The dose of ADR was 3.5 mg/kg,once per week.The modeling lasted for 6 weeks.Left ventricular ejection fraction (LVEF),left ventricular fraction shortening (LVFS),brain natriuretic peptide (BNP),heart rate (HR),respiratory rate (RR),urine output,ear temperature,exhaustive swimming test (EST),Tri-iodothyronine (T3),tetra-iodothyronine (T4),thyroid stimulating hormone (TSH) as well as heart,lung,liver weight indices and their pathological sections were integrated and compared.Results Compared with the Control group,LVEF,LVFS,BNP,HR,RR,heart,lung,liver weight indices,urine output,ear temperature,EST,and T3,T4,and TSH changed significantly in the ADR group,the PTU group,and the ADR + PTU group with statistical significance (P <0.05),and pathological changes of heart failure occurred in pathological sections of heart,lung,and liver.Compared with the ADR group,LVEF,LVFS,BNP,and lung,liver weight indices,urine output,ear temperature,T3,T4,and TSH changed significantly in the ADR + PTU group with statistical significance (P < 0.05),and

  17. Establishment of FMEA risk management procedures for blood coagulation tests in clinical laboratories%临床实验室按照 FM EA 模式构建凝血功能检测项目的风险管理程序

    牛广华; 高玉洁; 崔百慧

    2016-01-01

    使用FMEA模型确定检验医学中心风险管理工作流程和关键环节。根据IS015189认可准则、CAP实验室认可检查条款等的相关标准,识别出实验室凝血功能检测工作流程中关键环节的风险。针对凝血功能检测的评价活动,采取积极的纠正措施,通过监测系统周期性地审核性能数据,可以对凝血功能检测的质量持续改进。(中华检验医学杂志,2016,39:13-17)%Definiting the workflow and key link of the risk management in medical laboratory by FMEA.Identifying risk factors of the workflow and key link of blood coagulation test by the criteria for laboratory accreditation , such as ISO15189 recognition criteria and CAP laboratory accreditation inspection . Through the evaluation of the blood coagulation test , effective corrective actions and examining performance data periodically , the quality of the blood coagulation test can be improved continuously.

  18. 大鼠高血流性肺动脉高压模型建立及病理生理改变%Establishment and pathophysiological changes of a rat model of increased blood flow-induced pulmonary arterial hypertension by anastomosis of the left common carotid artery to left external jugular vein

    赵科研; 李红岩; 王辉山; 佟昌慈; 张玉彪; 施琳; 侯明晓

    2015-01-01

    test using SPSS 16.0.Results There was no significant difference in body weight gains between the groups .The patency rate of shunt was 84.6%.The heart was enlarged in the group shunt .Cardiac output increased significantly in the shunt group than that in the other two groups [(309.8 ±33.1) mL/min・kg vs.(245.6 ±31.9) mL/min・kg, (240.8 ±30.9)mL/min・kg, respectively, P<0.05].In the shunt group Qp/Qs was 2.16 ±0.38 and RVSP increased to (35.8 ±4.9) mmHg, RVHI was 0.3263 ± 0.0342, significantly higher than that of the other groups .The pulmonary arteriolar wall was evidently thickened in contrast to that in the sham group [ ( 22.3 ±1.7 )% vs.( 10.6 ±1.7 )%, P <0.05 ) .Conclusions Anastomosis of the left common carotid artery to left external jugular vein can successfully establish pulmonary arterial hypertension model induced by high blood flow in rats .

  19. Cancer diagnosis by autofluorescence of blood components

    Masilamani, V. E-mail: masilamaniv@yahoo.com; Al-Zhrani, K.; Al-Salhi, M.; Al-Diab, A.; Al-Ageily, M

    2004-09-01

    The autofluorescence of blood components of healthy volunteers and cancer patients of different etiology were analyzed using a steady-state spectrofluorometer. A significant contrast between healthy and diseased blood could be established. Blood components of patients of gastric cancer, breast cancer and Hodgkin's lymphoma showed distinct and enhanced fluorescence band (around 630 nm) due to the porphyrin fluorophore. From the ratio fluorometry, a correlation to the stages of cancer could be also brought forth. We could indicate reasonably well the features of early stages and the growth rate of a few cancers and benign tumors.

  20. Effect of perioperative blood transfusions on long term graft outcomes in renal transplant patients.

    O'Brien, Frank J

    2012-06-01

    It is established that blood transfusions will promote sensitization to human leucocyte antigen (HLA) antigens, increase time spent waiting for transplantation and may lead to higher rates of rejection. Less is known about how perioperative blood transfusion influence patient and graft outcome. This study aims to establish if there is an association between perioperative blood transfusion and graft or patient survival.

  1. High Blood Pressure (Hypertension)

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  2. High blood pressure medications

    ... this page: //medlineplus.gov/ency/article/007484.htm High blood pressure medicines To use the sharing features on this page, please enable JavaScript. Treating high blood pressure will help prevent problems such as heart disease, ...

  3. Blood Clotting and Pregnancy

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  4. Blood Clotting and Pregnancy

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    ... Home > Donating Blood > Donation Process Printable Version Donation Process View Video Getting Ready for Your Donation The ... worry about. Make a Donation Appointment The Donation Process Step by Step Donating blood is a simple ...

  6. Hyperglycemia (High Blood Glucose)

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  8. Blood Pressure Medicines

    High blood pressure, also called hypertension, usually has no symptoms. But it can cause serious problems such as stroke, heart ... kidney failure. If you cannot control your high blood pressure through lifestyle changes such as losing weight and ...

  9. Blood Clotting and Pregnancy

    Full Text Available ... ASH Apps Share Your Idea Donate My Account Search Show Main Menu + About Awards Membership ASH Foundation ... help: Results of Clinical Studies Published in Blood Search Blood , the official journal of ASH, for the ...

  10. Hyperglycemia (High Blood Glucose)

    Full Text Available ... and eAG Hypoglycemia (Low blood glucose) Hyperglycemia (High blood glucose) Dawn Phenomenon Checking for Ketones Tight Diabetes Control donate en -- Diabetes Must Be Stopped - 2016-06-donation- ...

  11. Genetics Blood Card Use

    US Fish and Wildlife Service, Department of the Interior — SOP guiding collection of blood for genetics analysis. Provides stepwise instructions and guidance on how to collect DNA sample using a whole blood blot card

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  13. Blood Sugar and Fats

    ... hyperglycemia) can be a sign of the disease diabetes mellitus. High blood sugar levels can eventually damage ... treated with the same medications used to treat diabetes. There is no simple blood test for insulin ...

  14. America's Blood Centers

    ... or less. Please donate now! Full Stoplight Report America's Blood Centers is... FEATURED TODAY Support the Foundation ... purchase will be donated to the Foundation for America's Blood Centers! Simply Click Here! "We Are" This ...

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    Full Text Available ... blood clots A genetic predisposition to blood clots Obesity Prolonged immobility (e.g., bedrest, long distance travel) ... Programs and Awards ASH Agenda for Hematology Research Education For Clinicians For Trainees For Educators For Patients ...

  16. Hypertension (High Blood Pressure)

    ... blood pressure with the development of a practical method to measure it. Physicians began to note associations between hypertension and risk of heart failure, stroke, and kidney failure. Although scientists had yet to prove that lowering blood pressure ...

  17. Hyperglycemia (High Blood Glucose)

    Full Text Available ... Risk Healthy Eating Overweight Smoking High Blood Pressure Physical Activity High Blood Glucose My Health Advisor Tools To ... Index Low-Calorie Sweeteners Sugar and Desserts Fitness Exercise & Type 1 Diabetes Get Started Safely Get And ...

  18. Blood Clotting and Pregnancy

    Full Text Available ... harming your baby. Jump To: Am I at Risk? The risk of developing a blood clot during pregnancy is ... prevent blood clots during pregnancy: Be aware of risk factors. Know your family history. Make sure your ...

  19. Symptoms of Blood Disorders

    ... 2 Diabetes, Heart Disease a Dangerous Combo Are 'Workaholics' Prone to OCD, Anxiety? ALL NEWS > Resources First ... Blood Disorders Bone Marrow Examination Blood disorders can cause various symptoms in almost any area of the ...

  20. Blood Clotting and Pregnancy

    Full Text Available ... Advances A peer-reviewed, online only, open access journal with a unique focus on scholarly and educational ... Studies Published in Blood Search Blood , the official journal of ASH, for the results of the latest ...

  1. Blood Clotting and Pregnancy

    Full Text Available ... Hematologist Clinical Trials Talking with Your Doctor Patient Group Links Advocacy Toolkit Home For Patients Blood Disorders ... a request to the Blood Publishing Office . Patient Groups A list of Web links to patient groups ...

  2. Blood Culture Test

    ... difficult to grow in culture, and additional blood cultures using special nutrient media may be done to try to grow and identify the pathogen . Viruses cannot be detected using blood culture bottles designed to grow bacteria. If the health ...

  3. National Blood Clot Alliance

    ... Navigation Home About Us Mission & Vision Board of Directors and Officers Medical & Scientific Advisory Board (MASAB) NBCA Operations Programs & Services About Clots Know Your Risk for Blood Clots Signs and Symptoms of Blood ...

  4. Home blood sugar testing

    Check your blood sugar level as often as instructed by your health care provider. Write down the results. This will tell you how ... everyone with diabetes needs to check their blood sugar every day. Some people need to check it ...

  5. Ferritin blood test

    Serum ferritin level ... The amount of ferritin in the blood (serum ferritin level) is directly related to the amount of iron stored in your body. Iron is important for red blood cell production. Your doctor ...

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    Full Text Available ... Blood: How I Treat A compendium of Blood articles that have been updated to reflect the most ... Sixth Edition Hematology 2015 A collection of review articles from the Education Program at the 2015 ASH ...

  7. Anthrax - blood test

    ... The best test for diagnosing anthrax is a culture of affected tissue or blood. Alternative Names Anthrax serology test; Antibody test for anthrax; Serologic test for B anthracis Images Blood test Bacillus anthracis References Hall GS, Woods GL. Medical bacteriology. ...

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    Full Text Available ... pregnancy: Be aware of risk factors. Know your family history. Make sure your doctor knows about any ... blood clots or blood clotting disorders in your family. Remain active, with your doctor's approval. Be aware ...

  9. Blood and Lymph Diseases

    ... in direct contact with the external environment, the circulatory system acts as a transport system for these cells. Two distinct fluids move through the circulatory system: blood and lymph. Blood carries oxygen and nutrients ...

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    Full Text Available ... Health Step On Up Treatment & Care Blood Glucose Testing Medication Doctors, Nurses & More Oral Health & Hygiene Women ... Living With Diabetes > Treatment and Care > Blood Glucose Testing Share: Print Page Text Size: A A A ...

  11. Blood Clotting and Pregnancy

    Full Text Available ... Patients Resources for Industry Professionals View all Guidelines & Quality Care Resources to help practitioners improve patient care ... Concierge View all meetings Publications Blood Current Issue First Edition Abstracts Blood: How I Treat A compendium ...

  12. Blood groups systems

    Ranadhir Mitra; Nitasha Mishra; Girija Prasad Rath

    2014-01-01

    International Society of Blood Transfusion has recently recognized 33 blood group systems. Apart from ABO and Rhesus system, many other types of antigens have been noticed on the red cell membranes. Blood grouping and cross-matching is one of the few important tests that the anaesthesiologist orders during perioperative period. Hence, a proper understanding of the blood group system, their clinical significance, typing and cross-matching tests, and current perspective are of paramount importa...

  13. Blood Donation Management System

    K M Akkas Ali; Israt Jahan; Md. Ariful Islam; Md. Shafa-at Parvez

    2015-01-01

    This paper is focused on Blood Donation Management System which is a web application with supporting mobile application aimed to serve as a communication tool between patients (who need blood) and blood donor. To become members of the system, donors need to create their profiles by providing fundamental information like name, blood group, email address, password, and exact location from “Google Map”. In order to find out the exact location of a donor, Google Map is integrated with this app...

  14. The determination of chromium-50 in human blood and its utilization for blood volume measurements

    Possible relationships between insufficient blood volume increases during pregnancy and infant mortality could be established with an adequate measurement procedure. An accurate and precise technique for blood volume measurements has been found in the isotope dilution technique using chromium-51 as a label for red blood cells. However, in a study involving pregnant women, only stable isotopes can be used for labeling. Stable chromium-50 can be determined in total blood samples before and after dilution experiments by neutron activation analysis (NAA) or mass spectrometry. However, both techniques may be affected by insufficient sensitivity and contamination problems at the inherently low natural chromium concentrations to be measured in the blood. NAA procedures involving irradiations with highly thermalized neutrons at a fluence rate of 2x1013 n/cm2xs and low background gamma spectrometry are applied to the analysis of total blood. Natural levels of chromium-50 in human and animal blood have been found to be <0.1 ng/mL; i.e., total chromium levels of <3 ng/mL. Based on the NAA procedure, a new approach to the blood volume measurement via chromium-50 isotope dilution has been developed which utilizes the ratio of the induced activities of chromium-51 to the iron-59 in three blood samples taken from each individual, namely blank, labeled and diluted labeled blood. (author)

  15. Monitor blood glucose - slideshow

    ... medlineplus.gov/ency/presentations/100220.htm Monitoring blood glucose - Series—Monitoring blood glucose: Using a self-test meter To use the ... A.M. Editorial team. Related MedlinePlus Health Topics Blood Sugar A.D.A.M., Inc. is accredited by ...

  16. Blood Test: Glucose

    ... Things to Know About Zika & Pregnancy Blood Test: Glucose KidsHealth > For Parents > Blood Test: Glucose Print A A A Text Size What's in ... de sangre: glucosa What It Is A blood glucose test measures the amount of glucose (the main ...

  17. Right patient, Right blood

    Selberg, Hanne; Madsen, Trine Stougaard

    2014-01-01

    Right patient, Right Blood Simulation based training in blood transfusion practice in nursing education Background: In spite of strict checking procedures to handling transfusion of blood severe adverse reactions are likely to happen and the major cause of morbidity occurs to be liable to human...

  18. Hyperglycemia (High Blood Glucose)

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  19. Hyperglycemia (High Blood Glucose)

    ... by Mail Close www.diabetes.org > Living With Diabetes > Treatment and Care > Blood Glucose Testing Share: Print Page Text Size: ... and-how-tos, In this section Living With Diabetes Treatment and Care Blood Glucose Testing Checking Your Blood Glucose A1C ...

  20. Examining blood vessels

    This patent specification relates to an invention concerned with improvements in or relating to the examination of blood vessels of interest. Particles of dimensions not greater than 8 microns capable of providing detectable signals, are introduced into the blood for examination of a blood vessel. The particles may be sources of radiation, e.g. Ga68. (author)

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    Full Text Available ... by Mail Close www.diabetes.org > Living With Diabetes > Treatment and Care > Blood Glucose Testing Share: Print Page ... and-how-tos, In this section Living With Diabetes Treatment and Care Blood Glucose Testing Checking Your Blood ...

  2. What Is a Blood Transfusion?

    ... see "What Are the Risks of a Blood Transfusion?" ) Blood bank staff also screen each blood donation to find out whether it's type A, B, AB, or O and whether it's Rh-positive or Rh-negative. Getting a blood type that ... blood for a transfusion, some blood banks remove white blood cells. This ...

  3. Cord blood transplantation: can we make it better?

    Leland eMetheny

    2013-09-01

    Full Text Available Umbilical cord blood is an established source of hematopoietic stem cells for transplantation. It enjoys several advantages over bone marrow or peripheral blood, including increased tolerance for Human Leukocyte Antigen mismatches, decreased incidence of graft-versus-host disease, and easy availability. Unrelated cord blood does have limitations, however, especially in the treatment of adults. In the 24 years since the first umbilical cord blood transplant was performed, significant progress has been made, but delayed hematopoietic engraftment and increased treatment related mortality remain obstacles to widespread use. Here we summarize the latest results of unrelated cord blood transplants, and review strategies under investigation to improve clinical outcomes.

  4. Atomic Weapons Establishment Bill [Money

    The debate concerns the authorisation of payment of the money required to reorganise the atomic weapons establishment in the United Kingdom provided for in the Atomic Weapons Establishment Bill in progress through Parliament. In the Bill the contractorisation of the establishment is recommended and some sort of Government owned company operated scheme set up. The debate lasted about half an hour and is reported verbatim. The issues raised concerned the actual sums likely to be incurred in the formation of a Company to carry out the designated activities of the Bill. These are connected with the research, development, production or maintenance of nuclear devices and the premises needed. The government spokesman suggested the sums required to support the Bill would not be large and the resolution was agreed to without a vote. (UK)

  5. Blood Component Therapy

    Kelton, J. G.

    1984-01-01

    Human blood has been transfused for about 60-70 years. Over this time, the practice of blood transfusion has changed dramatically. One major change is the separation of blood into its various components. As a result, the patient can receive only the blood component in which he is deficient. In this way, the risk of side effects—particularly hepatitis—is lessened. This article briefly reviews the various blood products, the indications for their use, and some associated risks. These products i...

  6. BLOOD SERVICE IN FINLAND

    TASHTEMIROV K.K.; LATVALA E.; IMANGAZINOV S.B.

    2016-01-01

    The goal of the post is to summarize the experience of blood service in Finland by the result of the business move and examination of the service activities at the point.The research materials indicate that the blood service in Finland is a non-profit organization and is an independent part of the Finnish Red Cross (FRC). All expenses and development of Blood Service are covered by the sale of blood and blood products and expert services in the Finnish health care system. It is responsible fo...

  7. Methods to establish flaw tolerances

    Three conventional methods used to establish flaw tolerances are compared with new approaches using fracture mechanics. The conventional methods are those based on (a) non-destructive testing methods; (b) fabrication and quality assurance experience; and (c) service and damage experience. Pre-requisites of fracture mechanics methods are outlined, and summaries given of linear elastic mechanics (LEFM) and elastoplastic fracture mechanics (EPFM). The latter includes discussion of C.O.D.(crack opening displacement), the J-integral and equivalent energy. Proposals are made for establishing flaw tolerances. (U.K.)

  8. Blood Donation Management System

    K M Akkas Ali

    2015-06-01

    Full Text Available This paper is focused on Blood Donation Management System which is a web application with supporting mobile application aimed to serve as a communication tool between patients (who need blood and blood donor. To become members of the system, donors need to create their profiles by providing fundamental information like name, blood group, email address, password, and exact location from “Google Map”. In order to find out the exact location of a donor, Google Map is integrated with this application. The mobile application always updates the location of a donor. As a result, the system can automatically find a registered donor wherever he/she goes. Visitors can search blood donors from the home page by blood group and the place where blood is needed. The system will show the available donors along with their phone number, email address and mailing address through arranging them by nearest place and blood donation expire date. Visitors can send message to all donors through email but a member can send message using email and mobile phone. An appointment will be created only whenever a donor confirms that he/she will donate blood. Then the system will alert the donor before 12 hours of donation. Blood donors can also be searched from the mobile application, but this is only accessible for registered members. The goal of this paper is to reduce the complexity of the system to find blood donors in an emergency situation.

  9. Blood groups systems

    Ranadhir Mitra

    2014-01-01

    Full Text Available International Society of Blood Transfusion has recently recognized 33 blood group systems. Apart from ABO and Rhesus system, many other types of antigens have been noticed on the red cell membranes. Blood grouping and cross-matching is one of the few important tests that the anaesthesiologist orders during perioperative period. Hence, a proper understanding of the blood group system, their clinical significance, typing and cross-matching tests, and current perspective are of paramount importance to prevent transfusion-related complications. Nonetheless, the knowledge on blood group system is necessary to approach blood group-linked diseases which are still at the stage of research. This review addresses all these aspects of the blood groups system.

  10. Blood groups systems.

    Mitra, Ranadhir; Mishra, Nitasha; Rath, Girija Prasad

    2014-09-01

    International Society of Blood Transfusion has recently recognized 33 blood group systems. Apart from ABO and Rhesus system, many other types of antigens have been noticed on the red cell membranes. Blood grouping and cross-matching is one of the few important tests that the anaesthesiologist orders during perioperative period. Hence, a proper understanding of the blood group system, their clinical significance, typing and cross-matching tests, and current perspective are of paramount importance to prevent transfusion-related complications. Nonetheless, the knowledge on blood group system is necessary to approach blood group-linked diseases which are still at the stage of research. This review addresses all these aspects of the blood groups system. PMID:25535412

  11. Monitoring Blood Sugar: The Importance of Checking Blood Sugar Levels

    ... 5 Things to Know About Zika & Pregnancy Monitoring Blood Sugar KidsHealth > For Parents > Monitoring Blood Sugar Print ... Other Tests Record Keeping The Importance of Checking Blood Sugar Levels Besides helping to keep blood sugar ...

  12. Methods for improving PGPR establishment

    Plant growth-promoting rhizobacteria (PGPR) are often touted as a useful means to improve crop productivity and sustainability. However, field studies with PGPR inoculants often result in limited PGPR establishment and colonization, highlighting the need to better understand the factors involved in...

  13. Establishing a Suicide Prevention Program.

    Vidal, John A.

    1986-01-01

    Outlines important considerations for establishing suicide prevention programs in high schools. Teenage suicide rate has doubled since 1970. To deal with this crisis schools must develop procedures for detecting potential victims and for helping students and staff cope after a suicide. Schools must not be afraid to talk about suicide; avoiding the…

  14. A well-established profession

    Braae, Ellen Marie; Hare, Richard Andrew

    2011-01-01

    It was during the economic boom of the 1960s that the demand for landscape architects began to explode in Denmark as the expanding welfare state brought about rapid physical changes. At this time the country’s first specific education for landscape architects was established and 2010 marked the 5...

  15. Statins improve the resolution of established murine venous thrombosis

    Kessinger, Chase W; Kim, Jin Won; Henke, Peter K;

    2015-01-01

    significantly reduced stasis venous thrombus burden by 25% without affecting lipid levels, blood coagulation parameters, or blood cell counts. Statin-driven reductions in VT burden (thrombus mass for stasis thrombi, intravital microscopy thrombus area for non-stasis thrombi) compared similarly to the......-lipid-lowering agents with anti-thrombotic and anti-inflammatory properties-in decreasing thrombus burden and decreasing vein wall injury, mediators of PTS, in established murine stasis and non-stasis chemical-induced venous thrombosis (N = 282 mice). Treatment of mice with daily atorvastatin or rosuvastatin...... therapeutic anticoagulant effects of low molecular weight heparin. Blood from statin-treated mice showed significant reductions in platelet aggregation and clot stability. Statins additionally reduced thrombus plasminogen activator inhibitor-1 (PAI-1), tissue factor, neutrophils, myeloperoxidase, neutrophil...

  16. Use of blood and blood products.

    Hunt, E; Wood, B

    1999-11-01

    It is sometimes necessary for the practitioner to transfuse the ruminant with whole blood or plasma. These techniques are often difficult to perform in practice, are time-consuming, expensive, and stressful to the animal. Acute loss of 20% to 25% of the blood volume will result in marked clinical signs of anemia, including tachycardia and maniacal behavior. The PCV is only a useful tool with which to monitor acute blood loss after intravascular equilibration with other fluid compartments has occurred. An acutely developing PCV of 15% or less may require transfusion. Chronic anemia with PCV of 7% to 12% can be tolerated without transfusion if the animal is not stressed and no further decline in erythrocyte mass occurs. Seventy-five percent of transfused bovine erythrocytes are destroyed within 48 hours of transfusion. A transfusion rate of 10 to 20 mL/kg recipient weight is necessary to result in any appreciable increase in PCV. A nonpregnant donor can contribute 10 to 15 mL of blood/kg body weight at 2- to 4-week intervals. Sodium citrate is an effective anticoagulant, but acid citrate dextrose should be used if blood is to be stored for more than a few hours. Blood should not be stored more than 2 weeks prior to administration. Heparin is an unsuitable anticoagulant because the quantity of heparin required for clot-free blood collection will lead to coagulation defects in the recipient. Blood cross-matching is only rarely performed in the ruminant. In field situations, it is advisable to inject 200 mL of donor blood into the adult recipient and wait 10 minutes. If no reaction occurs, the rest of the blood can probably be safely administered as long as volume overload problems do not develop. Adverse reactions are most commonly seen in very young animals or pregnant cattle. Signs of blood or plasma transfusion reaction include hiccoughing, tachycardia, tachypnea, sweating, muscle tremors, pruritus, salivation, cough, dyspnea, fever, lacrimation, hematuria

  17. Ancestry informative markers and complete blood count parameters in Brazilian blood donors

    Gabriela E. S. Felix; Kiyoko Abe-Sandes; Taísa M. Bonfim; Maria T. Bendicho; Patrícia Cisneiros; Rosalina Guedes; Cláudio J. F. Brandão; Alex J. L. Torres; Carlos Brites; Eduardo M. Netto; Roberto Meyer; Songeli M. Freire

    2010-01-01

    A complete blood count is very useful in clinical diagnoses when reference ranges are well established for the population. Complete blood counts and allele frequencies of Ancestry Informative Markers (AIMs) were analyzed in Brazilians with the aim of characterizing the hematological values of an admixed population. Positive associations were observed between gender and neutrophils, monocytes, eosinophils, erythrocytes, hemoglobin, hematocrit, MCV, MCHC and platelet counts. No significant diff...

  18. A new donor system for the patients with thalassemia: "Blood mother and blood father"

    Canatan Duran; Ozsancak Ahmet

    2010-01-01

    Background : Donor recruitment programs differ in countries depending on local conditions and causes. Regularly voluntary blood donation rate should be 5% of the population but it is extremely low in Turkey. In 1998, "Thalassemia flowers don′t fade" campaigning was started to get regular voluntary blood for patients with thalassemia. We would like to present results of our campaigning. Materials and Methods: The Thalassemia center was established in Antalya on the 1 st June 1994...

  19. What Causes High Blood Pressure?

    ... whether imbalances in this system cause high blood pressure. Blood Vessel Structure and Function Changes in the structure ... can affect blood pressure. Genetic Causes of High Blood Pressure Much of the understanding of the body systems ...

  20. Controlling your high blood pressure

    ... that is healthy for you. Checking Your Blood Pressure Your blood pressure can be measured at many places, including: ... Alternative Names Controlling hypertension Images Taking your blood pressure at home Blood pressure check Low sodium diet References American Diabetes ...

  1. What Is High Blood Pressure?

    ... also known as blood vessels and capillaries. The pressure --- blood pressure --- is the result of two forces. The ... was last reviewed on 08/04/2014. High Blood Pressure • Home • About High Blood Pressure (HBP) Introduction What ...

  2. High Blood Pressure Fact Sheet

    ... much alcohol. Signs and Symptoms of High Blood Pressure High blood pressure usually has no warning signs or symptoms , ... they are at high risk for high blood pressure . Blood Pressure Levels Normal systolic: less than 120 mmHg ...

  3. A new donor system for the patients with thalassemia: "Blood mother and blood father"

    Canatan Duran

    2010-01-01

    Full Text Available Background : Donor recruitment programs differ in countries depending on local conditions and causes. Regularly voluntary blood donation rate should be 5% of the population but it is extremely low in Turkey. In 1998, "Thalassemia flowers don′t fade" campaigning was started to get regular voluntary blood for patients with thalassemia. We would like to present results of our campaigning. Materials and Methods: The Thalassemia center was established in Antalya on the 1 st June 1994 by Ministry of Health, Turkey, because the incidence of thalassemia is very high in the Antalya region. A total of 388 patients with thalassemia were followed up regularly in the center. The annually blood requirement was approximately 5000 units per year. In 1998, a new program of blood donation for patients with thalassemia called "BLOOD MOTHER and BLOOD FATHER" was started with the support of Governor of Antalya and health management system in Antalya. Results : Between year 1998 and 2006, a total 3000 voluntary blood donors between age 18 and 65 years, of which 2160 males (72% and 840 were females (28%, had participated in this program. Conclusion: "Blood Mother and Blood Father" campaign was successful donor recruitment program for thalassemic care. After 2006, this program is now adopted and run by Turkish Red Crescent and Thalassemia Federation of Turkey for all thalassemics in Turkey.

  4. Blood donation and risk of polycythemia vera

    Edgren, Gustaf; Nyrén, Olof; Hultcrantz, Malin; Nielsen, Kaspar Rene; Pedersen, Ole B V; Björkholm, Magnus; Rostgaard, Klaus; Hjalgrim, Henrik

    2016-01-01

    BACKGROUND: It has been suggested that blood donors could have an increased risk of polycythemia vera (PV). However, no study has assessed whether frequent donors have a higher PV risk than less frequent donors. STUDY DESIGN AND METHODS: From the Scandinavian Donations and Transfusions (SCANDAT2......) database, we established a cohort of blood donors who had donated whole blood at least once between 1980 and 2012. Within this cohort we first assessed the risk of PV, comparing the donors to the general population using standardized incidence ratios (SIRs) with corresponding 95% confidence intervals (CIs......). To assess the association between frequency of blood donation and risk of PV we then conducted a case-control study nested within the cohort, where we compared prior donation activity among donors who were diagnosed with PV and matched controls. Here odds ratios (ORs) were used as measures of...

  5. Blood porphyrin luminescence and tumor growth correlation

    Courrol, Lilia Coronato; Silva, Flávia Rodrigues de Oliveira; Bellini, Maria Helena; Mansano, Ronaldo Domingues; Schor, Nestor; Vieira, Nilson Dias, Jr.

    2007-02-01

    Fluorescence technique appears very important for the diagnosis of cancer. Fluorescence detection has advantages over other light-based investigation methods: high sensitivity, high speed, and safety. Renal cell carcinoma (RCC) accounts for approximately 3% of new cancer incidence and mortality in the United States. Unfortunately many RCC masses remain asymptomatic and nonpalpable until they are advanced. Diagnosis and localization of early carcinoma play an important role in the prevention and curative treatment of RCC. Certain drugs or chemicals such as porphyrin derivatives accumulate substantially more in tumors than normal tissues. The autofluorescence of blood porphyrin of healthy and tumor induced male SCID mice was analyzed using fluorescence and excitation spectroscopy. A significant contrast between normal and tumor blood could be established. Blood porphyrin fluorophore showed enhanced fluorescence band (around 630 nm) in function of the tumor growth. This indicates that either the autofluorescence intensity of the blood fluorescence may provide a good parameter for the "first approximation" characterization of the tumor stage.

  6. Arterial Blood Carbonic Acid Inversely Determines Lactic and Organic Acids

    Aiken, Christopher Geoffrey Alexander

    2013-01-01

    Objective: To establish that arterial blood carbonic acid varies inversely with lactic acid in accordance with bicarbonate exchanging for lactate across cell membranes through the anion exchange mechanism to maintain the Gibbs-Donnan equilibrium.

  7. The effects of blood pressure reduction and of different blood pressure-lowering regimens on major cardiovascular events according to baseline blood pressure : meta-analysis of randomized trials

    Czernichow, Sebastien; Zanchetti, Alberto; Turnbull, Fiona; Barzi, Federica; Ninomiya, Toshiaru; Kengne, Andre-Pascal; Lambers Heerspink, Hiddo J.; Perkovic, Vlado; Huxley, Rachel; Arima, Hisatomi; Patel, Anushka; Chalmers, John; Woodward, Mark; MacMahon, Stephen; Neal, Bruce

    2011-01-01

    Background The benefits of reducing blood pressure are well established, but there remains uncertainty about whether the magnitude of the effect varies with the initial blood pressure level. The objective was to compare the risk reductions achieved by different blood pressure-lowering regimens among

  8. Establishment of ITER: Relevant documents

    At the Geneva Summit Meeting in November, 1985, a proposal was made by the Soviet Union to build a next-generation tokamak experiment on a collaborative basis involving the world's four major fusion blocks. In October, 1986, after consulting with Japan and the European Community, the United States responded with a proposal on how to implement such an activity. Ensuing diplomatic and technical discussions resulted in the establishment, under the auspices of the IAEA, of the International Thermonuclear Experimental Reactor Conceptual Design Activities. This tome represents a collection of all documents relating to the establishment of ITER, beginning with the initial meeting of the ITER Quadripartite Initiative Committee in Vienna on 15-16 March, 1987, through the meeting of the Provisional ITER Council, also in Vienna, on 8-9 February, 1988

  9. Blood histamine release: A new allergy blood test

    Allergen-mediated histamine release from human leukocytes represents an important model for in vitro studies of allergic reactions. The purpose of this study was to determine whether the measurement of histamine released in allergic patients (pts) by radioenzymatic assay following mixing of their blood with common allergens represents a reliable index for diagnosis of atopic allergy. Three categories of allergies were used: (1) housedust and mite; (2) cat and dog dander; (3) trees and grasses and ragweed mixture. The presence of allergy was established by intradermal skin testing in the study group of 82 pts. Significant atopy was defined as ≥ 3+ (overall range 0-4 +, negative to maximum) on skin testing. The test was carried out in tubes with 0.5 ml heparinized blood, 0.5 ml tris albumin buffer, and one of the allergens (60-100 PNU/ml). In 20 controls without allergy, there always was ≤ 4% histamine release (normal response). A significant allergen-mediated histamine release, ranging from 12 to 30% of the total blood histamine content, was observed in 96% of the pts with skin test sensitivity of ≥ 3+. There was good agreement between skin testing and histamine release in terms of the allergen causing the response. Thus, measurement of histamine release in blood in response to allergen challenge represents a clinically useful in vitro test for the diagnosis of atopic allergy. Because data can be obtained from a single sample and are highly quantitative, this new method should have application to the longitudinal study of allergic pts and to the assessment of interventions

  10. Factors affecting forage stand establishment

    Sulc R.M.

    1998-01-01

    Full Text Available Significant advances have been made in our knowledge of forage seed physiology, technology, and stand establishment practices; however, stand establishment continues to be one of the most common production problems affecting forage crops in the USA. There is a need for research on stand establishment of forage crops under abiotic and biotic stress. Although the forage seed industry produces and markets seed of high quality, new methods of assessing seed vigor are needed and their use should be expanded in the industry to enable matching seed lot performance to specific environmental conditions where performance can be maximized. Seed treatment and seed coating are used in the forage seed industry, and studies have shown they are of benefit in some environments. There is an increase in no-tillage seeding of forage crops, but improvements in the no-tillage planting equipment are needed to make them better suited to small seeds. Other recent developments in seeding techniques include broadcasting seed with dry granular and fluid fertilizers, which improves the efficiency of the seeding operation.

  11. Prevalence of hepatitis B & hepatitis C virus infections in potential blood donors in rural Vietnam

    Viet, Le; Le, Van Viet; Nguyen, Thi Ngoc Lan; Ty, Phung Xuan; Bjørkvoll, Bjørn; Hoel, Hedda B; Gutteberg, Tore Jarl; Husebekk, Anne; Larsen,Stig; Skjerve, Eystein; Husum, Hans

    2012-01-01

    Background & objectives: Safe blood and blood products should be offered to all patients in need for blood transfusion. The objectives of the present study were to establish prevalence estimates for hepatitis B and hepatitis C virus infections as a foundation for safe blood transfusion in rural Vietnam, and to check the accuracy of the laboratory analysis used for hepatitis testing of blood donors in Vietnam. Methods: A cross-sectional study was conducted in two rural communities in Quang Tri...

  12. Model 1: Blood

    Because most radiopharmaceuticals are introduced into the body via the vascular system and may remain in the circulation for prolonged periods of time, it is useful to have a model of the blood as an aid in the estimation of radiation dose. It is extremely difficult to devise a precise blood model; the geometry is complex and distribution of blood may vary with position, physiological state and disease process. Estimates of blood volume distribution vary among investigators. Furthermore, the regional hematocrit varies throughout the body, thus affecting distribution of the labeled material according to whether it is attached to cellular elements or in the plasma. The size of the blood pool volumes range from the heart to the capillaries. Variable amounts of non-penetrating radiation contributions to organs depend on the volume of blood in the various sized vessels and the energy of the electrons which may penetrate into tissue from the blood vessel. The present model represents an advance in that it takes into account to some extent the distribution of significant blood pools in the body. Further refinement of the macro-geometry is possible with data which can now be obtained from modern radionuclide imaging equipment. A more difficult problem is definging the micro-geometry relative to the distribution of blood in capillaries and sinusoids, and their relationship to one another

  13. Hyperglycemia (High Blood Glucose)

    Full Text Available ... Nephropathy) Gastroparesis Mental Health Step On Up Treatment & Care Blood Glucose Testing Medication Doctors, Nurses & More Oral Health & Hygiene Women A1C Insulin Pregnancy ...

  14. Hyperglycemia (High Blood Glucose)

    Full Text Available ... Disease (Nephropathy) Gastroparesis Mental Health Step On Up Treatment & Care Blood Glucose Testing Medication Doctors, Nurses & More Oral Health & Hygiene Women A1C Insulin ...

  15. Establishment of Glycosaminoglycan Assays for Mucopolysaccharidoses

    Shunji Tomatsu

    2014-08-01

    Full Text Available Mucopolysaccharidoses (MPS are a group of lysosomal storage disorders caused by deficiency of the lysosomal enzymes essential for catabolism of glycosaminoglycans (GAGs. Accumulation of undegraded GAGs results in dysfunction of multiple organs, resulting in distinct clinical manifestations. A range of methods have been developed to measure specific GAGs in various human samples to investigate diagnosis, prognosis, pathogenesis, GAG interaction with other molecules, and monitoring therapeutic efficacy. We established ELISA, liquid chromatography tandem mass spectrometry (LC-MS/MS, and an automated high-throughput mass spectrometry (HT-MS/MS system (RapidFire to identify epitopes (ELISA or disaccharides (MS/MS derived from different GAGs (dermatan sulfate, heparan sulfate, keratan sulfate, and/or chondroitin sulfate. These methods have a high sensitivity and specificity in GAG analysis, applicable to the analysis of blood, urine, tissues, and cells. ELISA is feasible, sensitive, and reproducible with the standard equipment. HT-MS/MS yields higher throughput than conventional LC-MS/MS-based methods while the HT-MS/MS system does not have a chromatographic step and cannot distinguish GAGs with identical molecular weights, leading to a limitation of measurements for some specific GAGs. Here we review the advantages and disadvantages of these methods for measuring GAG levels in biological specimens. We also describe an unexpected secondary elevation of keratan sulfate in patients with MPS that is an indirect consequence of disruption of catabolism of other GAGs.

  16. Acoustic comfort in eating establishments

    Svensson, David; Jeong, Cheol-Ho; Brunskog, Jonas

    2014-01-01

    The subjective concept of acoustic comfort in eating establishments has been investigated in this study. The goal was to develop a predictive model for the acoustic comfort, by means of simple objective parameters, while also examining which other subjective acoustic parameters could help explain...... the feeling of acoustic comfort. Through several layers of anal ysis, acoustic comfort was found to be rather complex, and could not be explained entirely by common subjective parameters such as annoyance, intelligibility or privacy. A predictive model for the mean acoustic comfort for an eating...

  17. Hospitals and health care establishments

    These guidelines have been drown up to assist all those involved in the management and maintenance of hospitals and health care establishments. Compliance with this guidance should minimise the risk of pollution occurring. The guidelines are jointly produced by the Environment Agency for England and Wales, the Scottish Environment Protection Agency and the Environment and Heritage Service for Northern Ireland, referred to as the Agency or Agencies. It includes guidelines on site drainage, sewage and waste water disposal, treatment of surface water drainage and waste management

  18. Fresh Whole Blood Transfusion: Military and Civilian Implications.

    Goforth, Carl W; Tranberg, John W; Boyer, Phillip; Silvestri, Peter J

    2016-06-01

    Uncontrolled hemorrhage and exsanguination are the leading cause of preventable death, and resuscitative therapy is a critical component for survival. In various combinations, fresh whole blood, blood components, colloids, and crystalloids have all been staples of trauma care. The use of fresh whole blood is a well-established military practice that has saved the lives of thousands of American and coalition military personnel. Civilian use of fresh whole blood is far less established owing to the wide availability of individual blood components. However, this highly tailored blood supply is vulnerable to both natural and man-made disasters. In the event of such disruption, such as a major hurricane, it may be necessary for civilian hospitals to rapidly enact a fresh whole blood program. Therefore, the aim of this article is to review the current use of blood therapy for trauma resuscitation, the US military's approach to fresh whole blood, and how maintaining a civilian capacity for fresh whole blood collection in the event of future man-made and natural disasters is key to promoting survival from trauma. PMID:27252101

  19. Preventing High Blood Pressure

    ... Heart Disease Cholesterol Salt Million Hearts® WISEWOMAN Preventing High Blood Pressure: Healthy Living Habits Recommend on Facebook Tweet Share ... meal and snack options can help you avoid high blood pressure and its complications. Be sure to eat plenty ...

  20. Give blood at CERN

    SC Unit

    2008-01-01

    ACCIDENTS and ILLNESSES don’t take a break! DO SOMETHING AMAZING - GIVE BLOOD! IT’S IN ALL OUR INTERESTS. 30 July 2008 from 9.30 a.m. to 4 p.m. CERN RESTAURANT NOVAE First floor - Salle des Pas Perdus After you have given blood, you are invited to partake of refreshments kindly offered by NOVAE.

  1. BLOOD DONORS CAMPAIGN

    2002-01-01

    Wednesday 13 November 2002 in restaurant nr 2, from 8.30 to 16.30 hrs will be held a blood donors campaign, organized by the Etablissement de Transfusion de Haute-Savoie If you already have a card giving your blood group, please bring this with you.

  2. BLOOD DONORS CAMPAIGN

    2001-01-01

    A blood donors campaign, organized by the Centre de Transfusion d'Annemasse will be held at CERN on Tuesday 14 November 2001 in restaurant nr 2, from 9.00 to 16.30 hrs If you already have a card giving your blood group, please bring this with you.

  3. BLOOD DONORS CAMPAIGN

    2002-01-01

    Tuesday 19 March 2002 in restaurant nr 2, from 9.00 to 16.30 hrs A blood donors campaign, organized by the Centre de Transfusion sanguine of Geneva If you already have a card giving your blood group, please bring this with you.

  4. BLOOD DONORS CAMPAIGN

    2000-01-01

    A blood donors campaign, organized by the Établissement de Transfusion de Rhône-Alpes will be held at CERN on Tuesday 14 November 2000 in restaurant nr 2, from 8.30 to 16.30 hrs If you already have a card giving your blood group, please bring this with you.

  5. BLOOD DONORS CAMPAIGN

    2001-01-01

    A blood donors campaign, organized by the Centre de Transfusion Sanguine of Geneva will be held at CERN on Tuesday 13 March 2001 in restaurant nr 2, from 9.00 to 16.30 hrs If you already have a card giving your blood group, please bring this with you.

  6. Virtual blood bank

    Kit Fai Wong

    2011-01-01

    Full Text Available Virtual blood bank is the computer-controlled, electronically linked information management system that allows online ordering and real-time, remote delivery of blood for transfusion. It connects the site of testing to the point of care at a remote site in a real-time fashion with networked computers thus maintaining the integrity of immunohematology test results. It has taken the advantages of information and communication technologies to ensure the accuracy of patient, specimen and blood component identification and to enhance personnel traceability and system security. The built-in logics and process constraints in the design of the virtual blood bank can guide the selection of appropriate blood and minimize transfusion risk. The quality of blood inventory is ascertained and monitored, and an audit trail for critical procedures in the transfusion process is provided by the paperless system. Thus, the virtual blood bank can help ensure that the right patient receives the right amount of the right blood component at the right time.

  7. Blood Clotting and Pregnancy

    Full Text Available ... Publications Blood Current Issue First Edition Abstracts Blood Advances A peer-reviewed, online only, open access journal with a unique focus on scholarly and educational content The Hematologist Features Diffusion President's Column ASH Clinical News Society News Clinical News Features ASH Self- ...

  8. Blood Clotting and Pregnancy

    Full Text Available ... Myths vs. Facts Blood Detectives Find a Hematologist Clinical Trials Talking with Your Doctor Patient Group Links Advocacy ... on Genome Editing Publications Blood The Hematologist ASH Clinical News ASH Self-Assessment ... Copyright © 2016 by American Society of Hematology Privacy Policy | Terms of Service | Contact Us

  9. ORANGE JUICE AND BLOOD PRESSURE

    M. F. VALIM; Barros, S.

    2009-01-01

    Blood pressure is the force of blood against artery walls. It is measured in millimeters of mercury (mm Hg) and recorded as two numbers: systolic pressure (as the heart contracts) over diastolic pressure (as the heart relaxes between beats). High blood pressure (hypertension) is defined as chronically elevated high blood pressure, with systolic blood pressure (SBP) of 140 mm Hg or greater, and diastolic blood pressure (DBP) of 90 mm Hg or greater. High blood pressure ...

  10. Quality of transfusion products in blood banking.

    Franchini, Massimo; Capuzzo, Enrico; Turdo, Rosalia; Glingani, Claudia

    2014-03-01

    The primary goal in transfusion medicine and cellular therapies is to promote high standards of quality and produce ever safer and more efficacious products. The establishment of a transfusion service quality management system, which includes several organizational structures, responsibilities, policies, processes, procedures, and resources, is now mandatory and widely regulated worldwide. In this review, we summarize the current knowledge on the quality system in transfusion medicine as applied to the production of blood components, including red blood cells, platelets, and fresh frozen plasma. PMID:24474089

  11. Establishment for Nuclear Equipment -Overview

    Research and development works conducted in the Establishment for Nuclear Equipment (ZdAJ) were focused around 3 subject areas: an accelerator for cancer treatment, therapeutical tables, systems and methods for controlling objects that cross international borders. The new, medium energy accelerator for cancer therapy cases is being designed in the Establishment for several years. In 2005 progress was achieved. A physical part, containing an electron beam has been completed and the parameters of that beam make it useful for therapeutical purposes. Consequently, the work on designing and testing of beam control systems, ensuring its high stability, repetition of irradiation parameters and accuracy of dosage have been started. Results of these tests make it very probable that 2006 will be the final year of scientific works and in 2007 the new apparatus will be ready for sales. Therapeutical tables have become a leading product of ZdAJ IPJ. Their technical parameters, reliability and universality in uses are appreciated by many customers of ZdAJ. In 2005, the table Polkam 16 was registered by the national Office for Registration of Medical Equipment as the first product of ZdAJ that meets all technical and formal requirements of the safety mark CE. This allows sales of the product on the market of the European Union. The research and development part of designing a therapeutical table for uses in the total body irradiation technique was also concluded in 2005. After the September 11 terrorist attacks on WTC a matter of controlling international borders have become a priority for many countries. In 2005 in ZdAJ IPJ, we conducted many preliminary calculations and experiments analyzing systems of irradiation sources, both photon and neutron as well as systems of detection and designing of signals triggered by controlling objects crossing the border. The results so far have enabled us to formulate a research project which has been positively evaluated by experts and found

  12. Establishing an ethanol production business

    Many Saskatchewan communities are interested in the potential benefits of establishing an ethanol production facility. A guide is presented to outline areas that communities should consider when contemplating the development of an ethanol production facility. Political issues affecting the ethanol industry are discussed including environmental impacts, United States legislation, Canadian legislation, and government incentives. Key success factors in starting a business, project management, marketing, financing, production, physical requirements, and licensing and regulation are considered. Factors which must be taken into consideration by the project manager and team include markets for ethanol and co-products, competent business management staff, equity partners for financing, production and co-product utilization technologies, integration with another facility such as a feedlot or gluten plant, use of outside consultants, and feedstock, water, energy, labour, environmental and site size requirements. 2 figs., 2 tabs

  13. AWRE: Atomic Weapons Research Establishment

    This reviews the work of AWRE at Aldermaston and Foulness. The main programme is nuclear and is concerned with the design and development of warheads for strategic and tactical nuclear weapons for the British nuclear deterrent, including those for the Royal Navy's missile carrying submarine fleet. The work is described grouped as design physics, development and materials. Services to these groups and to the whole establishment are provided by Engineering, Safety and Administration. The work ranges from long-term fundamental research, the development of technology, design, prototype development to the environmental testing of engineered products. In materials research the emphasis is on plutonium, uranium and beryllium, on high explosives and a wide range of inorganic and organic materials. The physics of the earth's crust is studied to aid detection of underground nuclear explosions. Reactor research facilities include the two reactors, Herald and Viper. (U.K.)

  14. Sociological establishment of 'normative facts'

    Vukićević Slobodan

    2002-01-01

    Full Text Available Every science is searching for 'it's facts', it's concept and categorical decree, and by this defines specific subject of it's science researching. Here, the researching is steered on identification of ontological contents of 'normative fact' in the aim of comprehension of it's categorical entity and conceptual disposition.'The normative fact' refers to importance, significance and sense which norm has, in other words, which is attributed to the norm by man and society, and which in the air of importance influence on it's behavior. Exclusive term of sociological science is 'normative fact' as behavior of an individual, groups, institutions and society with regard to establishment, application and changes of social norms.

  15. 干血滤纸片和白细胞酸性α-葡萄糖苷酶活性测定平台的建立及临床应用%Establishment and clinical application of dried blood spots and mixed leukocytes for determination of acid α-glucosidase activity

    邱文娟; 王霞; 王瑜; 叶军; 韩连书; 张惠文; 顾学范

    2010-01-01

    目的 建立干血滤纸片和门细胞酸性α-葡萄糖苷酶(GAA)活性测定方法 及正常参考值,用于糖原累积病Ⅱ型(GSD Ⅱ)患者的酶学诊断.方法 利用GAA特异性水解荧光底物4-MUG的原理,采用阿卡波糖抑制其同工酶,建立干血滤纸片(DBS)和白细胞测定GAA活性方法 .取700例DBS样本和100例白细胞样本作为正常对照建立DBS和白细胞测定GAA活性正常参考值,并对临床疑诊4例患者及其父母进行GAA活性测定.结果 DBS法具有良好的精密度,室温或低于室温保存至少4周时DBS GAA活性无明显影响.正常新生儿和儿童-成人DBS的GAA参考范围分别为8.92~60.03 pmol/(punch·h)和8.00~37.43 pmol/(punch·h);正常人白细胞GAA参考范围:12.56~50.26 nmol/(mg蛋白·h),共检出4例GSD Ⅱ型患者.结论 DBS法测定GAA活性具有敏感、快速、高通量等特点,适于GSD Ⅱ型高危人群筛查和诊断;白细胞法测定GAA活性也具有快速、特异性高等特点,适于患者的确诊.%Objective Glycogen storage disease type Ⅱ(GSD Ⅱ,Pompe disease)is caused by the deficiency of acid α-glucosidase(GAA)that leads to lysosomal glycogen accumulation.Early diagnosis and treatment of GSD Ⅱ are considered to be critical for maximum efficacy of the enzyme replacement therapy.The aim of this study was to introduce two reliable methods and to generate the reference range of GAA activitv.Method The assay of GAA activity was performed in dried blood spots(DBS)and mixed leukocytes with acarbose to eliminate isoenzyme interference and to generate the reference range.GAA activitv was assayed in 700 specimens for DBS from normal subjects and 100 specimens for mixed leukocytes from normal subjects to set up reference range.GAA activity in the samples of 4 patients who were clinically suspected of GSD Ⅱ and their parents were also assayed.Result The intra-run and inter-run precision of the DBS method wag less than 10%.GAA activity tested by DBS was

  16. Establishment of a nonmyeloablative allogeneic peripheral blood stem cell transplantation model in mice and its related study%非清髓同种异基因小鼠外周血造血干细胞移植模型的建立及其相关研究

    张琰; 孙宁; 汤唯艳; 朱华云; 刘雅恬; 赵刚; 吴剑秋

    2011-01-01

    . CD4 + CD25 + obviously declined in IV - PBSCT - DLI group while rose in the IBM - PBSCT or IBM - PBSCT - DLI group. Conclusion Mixed - chimerism can be achieved by using a nonmyeloabla-tive TBI and CTX - based conditioning regimen in combination with infusion of peripheral blood stem cells mobilized by rhG - CSF in fully H - 2 - mismatched recipient mice. DLI evidently pro motes the donor chimers and the incidence of GVHD is reduced remarkably. Additionally, the mechanism involved in this process is probably associated with the changes of T-cell sub-group.

  17. A question of blood, race, and politics.

    Kenny, Michael G

    2006-10-01

    This article explores the political and intellectual context of a controversy arising from a proposal made at the 1959 meetings of the American Society of Blood Banks to divide the blood supply by race. The authors, a group of blood-bankers and surgeons in New York, outlined difficulties in finding compatible blood for transfusion during open-heart surgery, which they attributed to prior sensitization of their patient, a Caucasian, by a previous transfusion from an African American donor. Examining the statistical distribution of blood-group antigens among the various races, they concluded that risk of adverse hemolytic reactions and the cost of testing could be reduced by establishing separate donor pools. The media reported the suggestion, which, given the political climate of the day, rapidly became a public issue involving geneticists, blood-bankers, physical anthropologists, and the African American medical community. Liberals condemned it, whereas eugenically inclined segregationists used the finding to support their views concerning evolutionary distance between the races and the dangers of miscegenation. Here we examine the contribution of comparative racial serology to this affair, the arguments and background of the main players, and the relevance of the debate to discussions about the role of "race" in post-genomic medicine. PMID:16788092

  18. Pancreatic blood flow in experimental acute pancreatitis

    The etiology and pathogenesis of acute necrotizing hemorrhagic pancreatitis remain controversial. Recent work has suggested that an early fall in pancreatic blood flow, causing ischemia, may be the initiating factor. Using an established rat model of hemorrhagic pancreatitis and the fractional indicator distribution technique with 86RbCl, pancreatic blood flow and tissue perfusion have been measured at various times in the condition. Six groups of ten rats were studied: control sham operation and pancreatitis groups were sacrificed at 1, 6, and 24 hr. Pancreatic blood flow (% of cardiac output) and perfusion (blood flow/g tissue) were measured. Blood flow was increased by a maximum of 53% at 1 hr (P less than 0.001) and remained elevated for 24 hr, and perfusion was increased by a maximum of 70% (P less than 0.001) at 1 hr and remained elevated at 6 hr. Pancreatic perfusion declines after 6 hr due to increasing gland edema. The results demonstrate a significant increase in pancreatic blood flow and perfusion in experimentally induced acute pancreatitis, suggesting a primary inflammatory response, and refute the ischemic etiological theory

  19. 基于EP-17 A2的胶体金法检测粪便隐血的空白限、检出限及定量限的建立及评价%Establishment and Evaluation of Blank Limit,Detection Limint and Quantitation Limit of Fecal Occult Blood Tests with Colloidal Gold Method Based on the Document of EP-1 7A2

    郭绪晓; 柏淑美; 张春来; 袁长金; 李金星

    2015-01-01

    目的:参考美国临床实验室标准化委员会(CLSI)发布的《临床实验室检验程序检测能力评价指南(第二版)》(EP-17A2)文件,探讨粪便隐血(FOB)胶体金法检测能力,建立该实验室的空白限(LOB)、检出限(LOD)及定量限(LOQ),减少弱阳性标本漏检率,并为胶体金法的检测限提供定量评价方法。方法使用人游离血红蛋白(f-Hb)ELISA试剂盒检测新鲜全血制备的系列低浓度的血红蛋白溶液,制定校准曲线,将粪便隐血的空白样本及一系列的血红蛋白低浓度样本使用胶体金试纸条进行检测,利用 Nato Checker710对显色带进行定量检测,并对定量结果进行统计分析,建立胶体金法检测粪便隐血的空白限、检出限及定量限。结果空白限为99.01 ng/ml,检出限为340.48 ng/ml,定量限为354.9 ng/ml。结论参考CLSI EP17-A2文件建立的检测限比常规方法建立的检测限科学合理,优于肉眼判断结果,更能满足临床实验室的质量要求和临床早期诊疗的需求;为提高实验室质量管理水平,每批次粪便隐血应根据此方法建立检测限,以及应用于其它项目胶体金法检出限的建立。%Objective To explore colloidal gold method used to detect fecal occult blood tests(FOB)detection capability and establish the laboratory standard operation of detecting FOB limit of blank(LOB),limit of detection (LOD)and quantifica-tion limit (LOQ)according to the CLSI document《Evaluation of Detection Capability for Clinical Laboratory Measurement Procedures;Approved Guideline-Second Edition》(EP17-A2),in order to reduce the false negative rate of the weakly positive samples,and to provide a way of quantitative detection for qualitative detection of colloidal gold method.Methods Detected series of solution of hemoglobin made of dissolved fresh whole blood with the ELISA kit of human free hemoglobin,and es-tablished the

  20. Home monitoring of blood pressure

    McGrath, Barry P

    2015-01-01

    Home blood pressure monitoring is the self-measurement of blood pressure by patients. In the diagnosis and management of high blood pressure it is complementary to 24-hour ambulatory blood pressure monitoring and clinic blood pressure measurements. Home monitoring can also help to identify white-coat and masked hypertension.

  1. Blood Pressure vs. Heart Rate

    ... Pressure High Blood Pressure Tools & Resources Stroke More Blood Pressure vs. Heart Rate Updated:Aug 30,2016 Blood ... was last reviewed on 08/04/2014. High Blood Pressure • Home • About High Blood Pressure (HBP) Introduction What ...

  2. Possible Risks of Blood Transfusions

    ... saved articles window. My Saved Articles » My ACS » Blood Transfusion and Donation + - Text Size Download Printable Version [PDF] » TOPICS Document ... Possible risks of blood transfusions Alternatives to blood transfusions Donating blood Blood donation by cancer survivors To learn more References Previous ...

  3. A VARIATIONAL MODEL FOR 2-D MICROPOLAR BLOOD FLOW

    He Ji-huan

    2003-01-01

    The micropolar fluid model is an essential generalization of the well-established Navier-Stokes model in the sense that it takes into account the microstructure of the fluid.This paper is devolted to establishing a variational principle for 2-D incompressible micropolar blood flow.

  4. Survival after blood transfusion

    Kamper-Jørgensen, Mads; Ahlgren, Martin; Rostgaard, Klaus;

    2008-01-01

    of transfusion recipients in Denmark and Sweden followed for up to 20 years after their first blood transfusion. Main outcome measure was all-cause mortality. RESULTS: A total of 1,118,261 transfusion recipients were identified, of whom 62.0 percent were aged 65 years or older at the time of their...... 17 years the SMR remained significantly 1.3-fold increased. CONCLUSION: The survival and relative mortality patterns among blood transfusion recipients were characterized with unprecedented detail and precision. Our results are relevant to assessments of the consequences of possible transfusion......-transmitted disease as well as for cost-benefit estimation of new blood safety interventions....

  5. Infections Transmitted By the Transfusion of Blood and Blood Products

    Tekin A.

    2011-01-01

    Especially viral hepatitis viruses and human immunodeficiency virus(HIV) which were transmitted by the transfusion of blood and blood products have been an important public health problem for a long time on the world. Transfusion of blood and blood products is an ideal and an easiest and a simplest route for transmission of infectious diseases. It is known that many infectious agents, either bacterial, viral, parasitic and fungal agents may be transmitted by the transfusion of blood and blood...

  6. Establishment for Nuclear Equipment: Overview

    Full text: The year 2003 was full of events in the Establishment for Nuclear Equipment (ZdAJ IPJ). The most important achievement of the Department in 2003 was the implementation of a new quality management system based on the EN/PN ISO 9000/2001 standard and medical equipment standard EN/PN ISO 13485. This duality management system covers all the activities of ZdAJ IPJ from design, construction, production, to supervision of the use of the manufactured products. The implementation of the new quality control system required much preparation. In particular, it was essential to: - define all the principal and auxiliary processes, - prepare specific maps of these processes, - define their measures and goals, - implement the systems and introduce any adjustments that proved to be necessary during its practical operation. In addition, in view of the growing number of contracts for customers abroad, it became desirable to implement an Internal System of Control for exports of strategic equipment. The result of this organizational work was a positive audit of the 3 systems of quality management done by Polish Centre for Testing and Certification member of IQnet. Among the most important activities in the research and development field was the construction of a new model of the therapeutical table - POLKAM 16. The construction of the prototype has been finished and the production process has already started. Another remarkable work concerns a 15 MeV electron accelerator. At present the main effort is being put in experimental test and accelerating system calculations. (author)

  7. Petten establishment. Annual report 1978

    1978 was the second year in the Joint Research Centre's 1977-1980 multiannual research programme. Since the following exercise is intended to run from 1980 to 1983 with a one year overlap, new proposals will be placed before the Council of Ministers in 1979. To this end, a considerable part of the programme and project management staff activities has been devoted to the peliminary preparation of future plans. In general it is expected that the Establishment's three research activities will continue along the lines already proceeding successfully in the present programme in the materials testing reactor (HFR), high temperature materials and organic chemistry spheres with some updating and refocussing where necessary. Consultation with the appropriate Advisory Committees for Programme Management has been contributed to these processes. Another important development has been the question of site security, following decisions of the European Commission and the Dutch Government to apply International Atomic Agency regulations. The work to apply the necessary measures has had to be executed in the shortest possible time. We have endeavoured to maintain and increase for all three programmes the already intensive contacts with research institutes and industry in the Member States. Important in this connection are the international conferences, 'Alloy 800' held in March and 'Ramping and Load following Behaviour of Reactor Fuel' in December, as well as an international meeting of the 'irradiation Devices Working Party' which took place in May

  8. Institute for Rock Magnetism established

    Banerjee, Subir K.

    There is a new focal point for cooperative research in advanced rock magnetism. The University of Minnesota in Minneapolis has established an Institute for Rock Magnetism (IRM) that will provide free access to modern equipment and encourage visiting fellows to focus on important topics in rock magnetism and related interdisciplinary research. Funding for the first three years has been secured from the National Science Foundation, the W.M. Keck Foundation, and the University of Minnesota.In the fall of 1986, the Geomagnetism and Paleomagnetism (GP) section of the AGU held a workshop at Asilomar, Calif., to pinpoint important and emerging research areas in paleomagnetism and rock magnetism, and the means by which to achieve them. In a report of this workshop published by the AGU in September 1987, two urgent needs were set forth. The first was for interdisciplinary research involving rock magnetism, and mineralogy, petrology, sedimentology, and the like. The second need was to ease the access of rock magnetists and paleomagnetists around the country to the latest equipment in modern magnetics technology, such as magneto-optics or electronoptics. Three years after the publication of the report, we announced the opening of these facilities at the GP section of the AGU Fall 1990 Meeting. A classified advertisement inviting applications for visiting fellowships was published in the January 22, 1991, issue of Eos.

  9. Blood Clotting and Pregnancy

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  10. Blood Clotting and Pregnancy

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  11. High Blood Pressure Medicines

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  13. Lead levels - blood

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  14. Blood Clotting and Pregnancy

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  15. Blood Test: Bilirubin

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  5. Order of blood draw

    Cornes, Michael; van Dongen-Lases, Edmée; Grankvist, Kjell;

    2016-01-01

    Medicine Working Group for the Preanalytical Phase (EFLM WG-PRE) provides an overview and summary of the literature with regards to order of draw in venous blood collection. Given the evidence presented in this article, the EFLM WG-PRE herein concludes that a significant frequency of sample contamination......, CLSI) guidelines recommend that the order of draw of blood during phlebotomy should be blood culture/sterile tubes, then plain tubes/gel tubes, then tubes containing additives. This prevents contamination of sample tubes with additives from previous tubes that could cause erroneous results. There have...... does occur if order of draw is not followed during blood collection and when performing venipuncture under less than ideal circumstances, thus putting patient safety at risk. Moreover, given that order of draw is not difficult to follow and knowing that ideal phlebotomy conditions and protocols...

  6. Hyperglycemia (High Blood Glucose)

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  9. Microbes and blood transfusion

    Narayan S

    2001-01-01

    Full Text Available Transfusion medicine has been constantly evolving through the years with improved technologies that enhance the capability of identifying existing and newer emerging transfusion transmissible infections (TTI. In spite of the efforts made by blood banks the risk of TTI remains. This article deals with the various steps involved in ensuring blood safety, i.e. donor selection, role of screening donated blood for known and emerging infections, issues and assessment of threat posed by the risk, methodologies employed for testing and possible suggestions to improve transfusion services. While the threat of TTI remains, with a concerted effort of private and government organisations, and co-operation from the diagnostic companies, it is possible to raise the levels of blood safety. A surveillance system is also essential to identify any new agents that might pose a threat in a geographic area and to include them too in the screening process.

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  11. Cord-Blood Banking

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  12. Special Blood Donation Procedures

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  13. Vitamin A blood test

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  19. Luteinizing hormone (LH) blood test

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  20. Manage your blood sugar (image)

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    Full Text Available ... providers diagnose high blood pressure when blood pressure readings are consistently 140/90 mmHg or above. Confirming ... minutes before the test. To track blood pressure readings over a period of time, the health care ...

  8. Multi-element analysis of blood plasma

    Two examples of multi-element analysis (MA) - semiconductor gamma spectrometry of natural and artificial radionuclides, and neutron activation analysis - of eight samples of lyophilized pooled plasma (a total of 124 subjects) from four localities of the regions Central Bohemia and Prague, show the scope for its use, e.g., in transfusion services. This consists in the use of ecological screening made up of five stages: preliminary rating of the intensity of ecological interactions in an individual or a group of blood donors; sample taking with the date and hour of sampling; determination of ecological interaction intensity tracers for an individual or for groups of blood donors using the appropriate MA method; comparisons of pre-rated and MA-established intensity of ecological interactions of an individual or a group of blood donors; standardization of MA results according to the date and hour of sampling. (author)

  9. A blood chemistry profile for lake trout

    Edsall, Carol Cotant

    1999-01-01

    A blood chemistry profile for lake trout Salvelinus namaycush was developed by establishing baseline ranges for several clinical chemistry tests (glucose, total protein, amylase, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, creatine kinase, calcium, and magnesium). Measurements were made accurately and rapidly with a Kodak Ektachem DT60 Analyzer and the Ektachem DTSC Module. Blood serum was collected from both laboratory-reared lake trout (1978 and 1986 year-classes) and feral spawning trout from Lake Michigan and then analyzed in the laboratory. No clinically significant differences were found between samples analyzed fresh and those frozen for 1 or 6 weeks. The ranges in chemistry variables for feral lake trout were generally wider than those for laboratory-reared lake trout, and significant differences existed between male and female feral lake trout for several tests. Blood chemistry profiles also varied seasonally on fish sampled repeatedly.

  10. Blood Screening for Influenza

    Hourfar, Michael Kai; Themann, Anna; Eickmann, Markus; Puthavathana, Pilaipan; Laue, Thomas; Seifried, Erhard; Schmidt, Michael

    2007-01-01

    Influenza viruses, including highly pathogenic avian influenza virus (H5N1), could threaten blood safety. We analyzed 10,272 blood donor samples with a minipool nucleic acid amplication technique. Analytical sensitivity of the method was 804 geq/mL and 444 geq/mL for generic influenza primers and influenza (H5N1) subtype–specific primers. This study demonstrates that such screening for influenza viruses is feasible.

  11. Medium of Blood

    Eddie Glenn

    2012-06-01

    Full Text Available Blood quantum, the measurement of American Indian ancestry possessed by members of America’s Indigenous nations, is most often considered a rubric utilized by the federal government in an oppressive form, or by tribal nations themselves as standards of tribal citizenship requirements. In this essay, the authors recontextualize blood as a medium of national identity within the context of the Cherokee Nation of Oklahoma. Such decentering, as presented here, illuminates Cherokee nationhood in ways that have significant political import.

  12. Integrated Blood Barcode Chips

    Fan, Rong; Vermesh, Ophir; Srivastava, Alok; Yen, Brian K.H.; Qin, Lidong; Ahmad, Habib; Kwong, Gabriel A.; Liu, Chao-Chao; Gould, Juliane; Hood, Leroy; Heath, James R.

    2008-01-01

    Blood comprises the largest version of the human proteome1. Changes of plasma protein profiles can reflect physiological or pathological conditions associated with many human diseases, making blood the most important fluid for clinical diagnostics2-4. Nevertheless, only a handful of plasma proteins are utilized in routine clinical tests. This is due to a host of reasons, including the intrinsic complexity of the plasma proteome1, the heterogeneity of human diseases and the fast kinetics assoc...

  13. Blood cell labelling

    The labelling of blood cells in vitro for subsequent in vivo studies was one of the earliest applications of radioactive tracers in clinical medicine and laid the foundations for many important contributions to the advancement of knowledge of human blood cell pathophysiology. The characteristics required for satisfactory clinical studies, the mechanisms of cell labelling, the problems of radiation or chemical damage to the labelled cells and some examples of modern clinical applications are described and discussed. (Author)

  14. Questions and Answers about High Blood Pressure

    ... Blood Pressure Page Content What is high blood pressure? Blood pressure is the force of blood against the ... do I know if I have high blood pressure? High blood pressure is often called "the silent killer" because ...

  15. Classification & Structure of Blood Vessels

    ... Thyroid & Parathyroid Glands Adrenal Gland Pancreas Gonads Other Endocrine Glands Review Quiz Cardiovascular System Heart Structure of the Heart Physiology of the Heart Blood Classification & Structure of Blood ...

  16. A survey of blood pressure in Lebanese children and adolescence

    Bassem Abou Merhi

    2011-01-01

    Full Text Available Background: Blood pressure varies between populations due to ethnic and environmental factors. Therefore, normal blood pressure values should be determined for different populations. Aims: The aim of this survey was to produce blood pressure nomograms for Lebanese children in order to establish distribution curves of blood pressure by age and sex. Subjects and Methods: We conducted a survey of blood pressure in 5710 Lebanese schoolchildren aged 5 to 15 years (2918 boys and 2792 girls, and studied the distribution of systolic and diastolic blood pressure in these children and adolescents. Blood pressure was measured with a mercury sphygmomanometer using a standardized technique. Results: Both systolic and diastolic blood pressure had a positive correlation with weight, height, age, and body mass index (r= 0.648, 0.643, 0.582, and 0.44, respectively (P < .001. There was no significant difference in the systolic and diastolic blood pressure in boys compared to girls of corresponding ages. However, the average annual increase in systolic blood pressure was 2.86 mm Hg in boys and 2.63 mm Hg in girls, whereas the annual increase in diastolic blood pressure was 1.72 mm Hg in boys and 1.48 mm Hg in girls. The prevalence of high and high-normal blood pressure at the upper limit of normal (between the 90th and 95th percentile, at risk of future hypertension if not managed adequately, was 10.5% in boys and 6.9% in girls, with similar distributions among the two sexes. Conclusions: We present the first age-specific reference values for blood pressure of Lebanese children aged 5 to 15 years based on a good representative sample. The use of these reference values should help pediatricians identify children with normal, high-normal and high blood pressure.

  17. A survey of blood pressure in Lebanese children and adolescence

    Bassem Abou Merhi

    2011-01-01

    Full Text Available Background: Blood pressure varies between populations due to ethnic and environmental factors. Therefore, normal blood pressure values should be determined for different populations. Aims : The aim of this survey was to produce blood pressure nomograms for Lebanese children in order to establish distribution curves of blood pressure by age and sex. Subjects and Methods: We conducted a survey of blood pressure in 5710 Lebanese schoolchildren aged 5 to 15 years (2918 boys and 2792 girls, and studied the distribution of systolic and diastolic blood pressure in these children and adolescents. Blood pressure was measured with a mercury sphygmomanometer using a standardized technique. Results: Both systolic and diastolic blood pressure had a positive correlation with weight, height, age, and body mass index (r= 0.648, 0.643, 0.582, and 0.44, respectively (P < .001. There was no significant difference in the systolic and diastolic blood pressure in boys compared to girls of corresponding ages. However, the average annual increase in systolic blood pressure was 2.86 mm Hg in boys and 2.63 mm Hg in girls, whereas the annual increase in diastolic blood pressure was 1.72 mm Hg in boys and 1.48 mm Hg in girls. The prevalence of high and high-normal blood pressure at the upper limit of normal (between the 90 th and 95 th percentile, at risk of future hypertension if not managed adequately, was 10.5% in boys and 6.9% in girls, with similar distributions among the two sexes. Conclusions: We present the first age-specific reference values for blood pressure of Lebanese children aged 5 to 15 years based on a good representative sample. The use of these reference values should help pediatricians identify children with normal, high-normal and high blood pressure.

  18. Profiles of blood and blood component transfusion recipients in Zimbabwe

    Mafirakureva, Nyashadzaishe; Khoza, Star; Hassall, Oliver; Faragher, Brian E.; Kajja, Isaac; Mvere, David A.; Emmanuel, Jean C.; Postma, Maarten J.; van Hulst, Marinus

    2015-01-01

    Background. There are limited published data on the characteristics of blood transfusion recipients in sub-Saharan Africa. This study describes the demographic characteristics of blood transfusion recipients and patterns of blood and blood component use in Zimbabwe. Materials and methods. Data on th

  19. Infections Transmitted By the Transfusion of Blood and Blood Products

    Tekin A.

    2011-05-01

    Full Text Available Especially viral hepatitis viruses and human immunodeficiency virus(HIV which were transmitted by the transfusion of blood and blood products have been an important public health problem for a long time on the world. Transfusion of blood and blood products is an ideal and an easiest and a simplest route for transmission of infectious diseases. It is known that many infectious agents, either bacterial, viral, parasitic and fungal agents may be transmitted by the transfusion of blood and blood products. In present study, we reviewed infection diseases that transmitted by the transfusion of blood and blood products.Additionally, we were aimed to emphasize a rare but a very important complication of transfusion of blood and blood products.

  20. Rotary blood pump

    Benkowski, Robert J. (Inventor); Kiris, Cetin (Inventor); Kwak, Dochan (Inventor); Rosenbaum, Bernard J. (Inventor); Bacak, James W. (Inventor); DeBakey, Michael E. (Inventor)

    1999-01-01

    A blood pump that comprises a pump housing having a blood flow path therethrough, a blood inlet, and a blood outlet; a stator mounted to the pump housing, the stator having a stator field winding for producing a stator magnetic field; a flow straightener located within the pump housing, and comprising a flow straightener hub and at least one flow straightener blade attached to the flow straightener hub; a rotor mounted within the pump housing for rotation in response to the stator magnetic field, the rotor comprising an inducer and an impeller; the inducer being located downstream of the flow straightener, and comprising an inducer hub and at least one inducer blade attached to the inducer hub; the impeller being located downstream of the inducer, and comprising an impeller hub and at least one impeller blade attached to the impeller hub; and preferably also comprising a diffuser downstream of the impeller, the diffuser comprising a diffuser hub and at least one diffuser blade. Blood flow stagnation and clot formation within the pump are minimized by, among other things, providing the inducer hub with a diameter greater than the diameter of the flow straightener hub; by optimizing the axial spacing between the flow straightener hub and the inducer hub, and between the impeller hub and the diffuser hub; by optimizing the inlet angle of the diffuser blades; and by providing fillets or curved transitions between the upstream end of the inducer hub and the shaft mounted therein, and between the impeller hub and the shaft mounted therein.

  1. Sufficient blood, safe blood: can we have both?

    Bönig Halvard; Schmidt Michael; Hourfar Kai; Schüttrumpf Jörg; Seifried Erhard

    2012-01-01

    Abstract The decision in September 2011 in the UK to accept blood donations from non-practicing men who have sex with men (MSM) has received significant public attention. Will this rule change substantially boost the number of blood donations or will it make our blood less safe? Clearly, most European countries have a blood procurement problem. Fewer young people are donating, while the population is aging and more invasive therapies are requiring more blood. Yet if that was the reason for al...

  2. Context-aware patient guidance during blood pressure self-measurement

    Sandager, Puk; Lindahl, Camilla; Schlütter, Jacob Mørup;

    2013-01-01

    The importance of accurate measurement of blood pressure in the screening and management of hypertension during pregnancy is well established. Blood pressure levels can be measured manually by healthcare staff or by using a blood pressure self-measurement device, either at home or in the clinic. In...... blood pressure self-measurement process. Preliminary results indicate that such active and context-aware guidance leads to more reliable measurements by inhibiting non-adherent patient behavior...

  3. 21 CFR 878.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    2010-04-01

    ... the Federal Food, Drug, and Cosmetic Act (the act). 878.9 Section 878.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY..., and Cosmetic Act (the act). The exemption from the requirement of premarket notification (section...

  4. 21 CFR 864.9 - Limitations of exemptions from section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act).

    2010-04-01

    ... ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY...) For assessing the risk of cardiovascular diseases; (5) For use in diabetes management; (6)...

  5. Types of Blood Pressure Medications

    ... Blood Pressure Tools & Resources Stroke More Types of Blood Pressure Medications Updated:Aug 26,2016 Many medications known ... was last reviewed on 08/04/2014. High Blood Pressure • Home • About High Blood Pressure (HBP) • Why HBP ...

  6. High Blood Pressure and Women

    ... High Blood Pressure Tools & Resources Stroke More High Blood Pressure and Women Updated:Aug 13,2014 Many people ... was last reviewed on 08/04/14. High Blood Pressure • Home • About High Blood Pressure (HBP) • Why HBP ...

  7. Manual versus automated blood sampling

    Teilmann, A C; Kalliokoski, Otto; Sørensen, Dorte B;

    2014-01-01

    corticosterone metabolites, and expressed more anxious behavior than did the mice of the other groups. Plasma corticosterone levels of mice subjected to tail blood sampling were also elevated, although less significantly. Mice subjected to automated blood sampling were less affected with regard to the parameters......Facial vein (cheek blood) and caudal vein (tail blood) phlebotomy are two commonly used techniques for obtaining blood samples from laboratory mice, while automated blood sampling through a permanent catheter is a relatively new technique in mice. The present study compared physiological parameters......, glucocorticoid dynamics as well as the behavior of mice sampled repeatedly for 24 h by cheek blood, tail blood or automated blood sampling from the carotid artery. Mice subjected to cheek blood sampling lost significantly more body weight, had elevated levels of plasma corticosterone, excreted more fecal...

  8. Management of Young Blood Donors

    Newman, Bruce H.

    2014-01-01

    The emphasis on high-school blood drives and acceptance of 16-year-old blood donors led to more research on physiologic and psychological ways to decrease vasovagal reaction rates in young blood donors and to increase donor retention. Research on how to accomplish this has been advantageous for the blood collection industry and blood donors. This review discussed the current situation and what can be done psychologically, physiologically, and via process improvements to decrease vasovagal rea...

  9. 75 FR 75483 - Guidance for Industry: Recommendations for Blood Establishments: Training of Back-Up Personnel...

    2010-12-03

    ... approved license application to FDA. In the Federal Register of November 19, 2009 (74 FR 59982), FDA... for single copies of the guidance to the Office of Communication, Outreach and Development (HFM-40... and Research (HFM-17), Food and Drug Administration, 1401 Rockville Pike, Suite 200N, Rockville,...

  10. 21 CFR 607.37 - Inspection of establishment registrations and blood product listings.

    2010-04-01

    ..., Office of Communication, Training and Manufacturers' Assistance (HFM-40), Center for Biologics Evaluation... Administration, Office of Communication, Training and Manufacturers' Assistance (HFM-40), Center for...

  11. Hyperglycemia (High Blood Glucose)

    Full Text Available ... In Memory In Honor Become a Member En Español Type 1 Type 2 About Us Online Community ... Page Text Size: A A A Listen En Español Hyperglycemia (High Blood Glucose) Hyperglycemia is the technical ...

  12. Nanosized blood microparticles

    Yuana, Yuana

    2011-01-01

    Microparticles (MPs) have important physiological and pathological roles in blood coagulation, inflammation and tumor progression. In recent years MPs also have been recognized to participate in important biological processes, such as in signaling and in the horizontal transfer of their specific pro

  13. Chemistry of Blood Type

    Coleman, William F.

    2005-01-01

    The molecule of December 2005 comes from the paper by Rose, Palcic and Evans on structural factors determining the blood type. The structure was previously reported by Palcic and Evans and is presented without the water molecule that is determined in the crystal structure.

  14. Hyperglycemia (High Blood Glucose)

    Full Text Available ... and-a1c-hyperglycemia,tips-and-how-tos, In this section Living With Diabetes Treatment and Care Blood ... ensureArray(data.submitSurveyResponse.errors); $.each(surveyErrors, function () { if (this.errorField) { $('input[name="' + this.errorField + '"]').closest('.form-group') . ...

  15. Blood pressure and atherosclerosis

    2010-01-01

    2010319 Effects of combined application of Xuezhikang capsule with hypotensive drugs on arterial compliance and smoothness of the dynamic blood pressure. ZHU Zongtao(朱宗涛),et al. Dept Cardiol, Centr People’s Hosp, Tengzhou 277500.Chin J Integr Tradit & West Med 2010;30

  16. Hyperglycemia (High Blood Glucose)

    Full Text Available ... produces daily around 4:00 a.m. to 5:00 a.m.). What are the Symptoms of Hyperglycemia? The signs and symptoms include the following: High blood glucose High levels of sugar in the urine Frequent urination Increased ...

  17. Blood transfusion and dermatology:

    Al Aboud, Ahmad; Al Aboud, Khalid; Al Hawsawi, Khalid; Jain, Nipun; Ramesh, V.

    2006-01-01

    Blood transfusion is an accepted therapeutic procedure in all specialties of medicine. In dermatology, specialized techniques like plasmapheresis and extracorporeal photochemotherapy have provided a good treatment option in immune-mediated disorders like bullous dermatoses, collagen vascular diseases and cutaneous lymphomas. Other anecdotal and less substantiated reports point to its use in chronic disorders like atopic dermatitis and psoriasis. Untowarddermatological manifestations include m...

  18. Hyperglycemia (High Blood Glucose)

    Full Text Available ... Complications DKA (Ketoacidosis) & Ketones Kidney Disease (Nephropathy) Gastroparesis Mental Health Step On Up Treatment & Care Blood Glucose Testing ... html Learn More Join Ryan Reed & Drive Your Health Access tools to help actively manage your diabetes. ... .survey-alert-wrap').remove(); if (data.submitSurveyResponse.success == 'false') { $('.survey-form'). ...

  19. Teaching "In Cold Blood."

    Berbrich, Joan D.

    1967-01-01

    The Truman Capote nonfiction novel, "In Cold Blood," which reflects for adolescents the immediacy of the real world, illuminates (1) social issues--capital punishment, environmental influence, and the gap between the "haves" and "have-nots," (2) moral issues--the complexity of man's nature, the responsibility of one man for another, and the place…

  20. CO2 blood test

    Bicarbonate test; HCO3-; Carbon dioxide test; TCO2; Total CO2; CO2 test - serum ... Many medicines can interfere with blood test results. Your health care provider will tell you if you need to stop taking any medicines before you have this test. DO ...

  1. Blood Clotting and Pregnancy

    Full Text Available ... Submit to Blood View all Annual Meeting Abstracts 2016 Call for Abstracts 2016 Abstract Review Categories Abstracts Archive View all Education ... ASH Workshop on Genome Editing July 14-15, 2016 Learn new techniques in the clinical application of ...

  2. Blood Clotting and Pregnancy

    Full Text Available ... your members of Congress to support continued medical research funding Take Action Meetings ASH Workshop on Genome Editing July 14- ... U.S. Surgeon General has issued a Call to Action on DVT and PE to raise public ... research on the causes, prevention, and treatment. Blood clots ...

  3. Blood Clotting and Pregnancy

    Full Text Available ... Edition Abstracts Collections Submit to Blood View all Annual Meeting Abstracts 2016 Call for Abstracts 2016 Abstract Review ... Abstracts Registration Housing Schedule and Program 58th ASH ® Annual Meeting & Exposition December 3-6, 2016, San Diego, CA ...

  4. Blood glucose monitoring.

    Davey, Sarah

    2014-06-10

    I found the CPD article on blood glucose monitoring and management in acute stroke care interesting and informative. As I am a mental health nursing student, my knowledge of chronic physical conditions is limited, so I learned a lot. PMID:24894257

  5. Hyperglycemia (High Blood Glucose)

    Full Text Available ... Size: A A A Listen En Español Hyperglycemia (High Blood Glucose) Hyperglycemia is the technical term for ... diabetes. Learn More: Stories of Courage, Love and Resilience - 2016-08-blog.html Learn More Stories of ...

  6. 21 CFR 640.1 - Whole Blood.

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Whole Blood. 640.1 Section 640.1 Food and Drugs... STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Whole Blood § 640.1 Whole Blood. The proper name of this product shall be Whole Blood. Whole Blood is defined as blood collected from human donors for...

  7. Toward a patient-based paradigm for blood transfusion

    Farrugia A

    2014-01-01

    Full Text Available Albert Farrugia,1,2 Eleftherios Vamvakas31College of Medicine, Biology and Environment, Australian National University, Acton, ACT, Australia; 2Centre for Orthopaedic Research, Department of Surgery, Faculty of Medicine and Surgery, University of Western Australia, Perth, WA, Australia; 3Cedars-Sinai Medical Center, Los Angeles, CA, USAAbstract: The current "manufacturing paradigm" of transfusion practice has detached transfusion from the clinical environment. As an example, fresh whole blood in large-volume hemorrhage may be superior to whole blood reconstituted from multiple components. Multicomponent apheresis can overcome logistical difficulties in matching patient needs with fresh component availability and can deliver the benefits of fresh whole blood. Because of the different transfusion needs of patients in emerging economies and the vulnerability of these blood systems to emerging infections, fresh whole blood and multicomponent apheresis can better meet patient needs when compared with transplants of the "manufacturing paradigm". We propose that patient blood management, along with panels of repeat, paid, accredited apheresis and fresh whole-blood donors can be used in emerging economies to support decentralized blood services. This alternative transfusion–medicine paradigm could eventually also be adopted by established economies to focus transfusion medicine on local patient needs and to alleviate the problem of the aging volunteer donor base.Keywords: indications, emerging countries, patient blood management

  8. High Blood Pressure and Kidney Disease

    ... to Remember Clinical Trials What is high blood pressure? Blood pressure is the force of blood pushing against ... filtering units called nephrons. [ Top ] How does high blood pressure affect the kidneys? High blood pressure can damage ...

  9. High Blood Pressure (Hypertension) (For Parents)

    ... lead an active, normal life. What Is Blood Pressure? Blood pressure is the force that blood puts on ... and medications. continue Long-Term Effects of High Blood Pressure When someone has high blood pressure, the heart ...

  10. Dengue viremia in blood donors in Northern India: Challenges of emerging dengue outbreaks to blood transfusion safety

    Sadhana Mangwana

    2015-01-01

    Backdround: Emerging infectious diseases pose threats to the general human population; including recipients of blood transfusions. Dengue is spreading rapidly to new areas and with increasing frequency of major outbreaks. Screening blood for dengue antigens in dengue-endemic countries would be costly and should, therefore, be recommended only after careful assessment of risk for infection and cost. Aim: A prospective study was conducted to establish the magnitude of the threat that dengue pos...

  11. Processing and storage of blood components: strategies to improve patient safety

    Pietersz RNI

    2015-08-01

    Full Text Available Ruby NI Pietersz, Pieter F van der Meer Department of Product and Process Development, Sanquin Blood Bank, Amsterdam, the Netherlands Abstract: This review focuses on safety improvements of blood processing of various blood components and their respective storage. A solid quality system to ensure safe and effective blood components that are traceable from a donor to the patient is the foundation of a safe blood supply. To stimulate and guide this process, National Health Authorities should develop guidelines for blood transfusion, including establishment of a quality system. Blood component therapy enabled treatment of patients with blood constituents that were missing, only thus preventing reactions to unnecessarily transfused elements. Leukoreduction prevents many adverse reactions and also improves the quality of the blood components during storage. The safety of red cells and platelets is improved by replacement of plasma with preservative solutions, which results in the reduction of isoantibodies and plasma proteins. Automation of blood collection, separation of whole blood into components, and consecutive processing steps, such as preparation of platelet concentrate from multiple donations, improves the consistent composition of blood components. Physicians can better prescribe the number of transfusions and therewith reduce donor exposure and/or the risk of pathogen transmission. Pathogen reduction in cellular blood components is the latest development in improving the safety of blood transfusions for patients. Keywords: blood components, red cell concentrates, platelet concentrates, plasma, transfusion, safety 

  12. Globalisation and blood safety.

    Farrugia, Albert

    2009-05-01

    Globalisation may be viewed as the growing interdependence of countries worldwide through the increasing volume and variety of cross-border transactions in goods and services, and also through the more rapid and widespread diffusion of technology. Globalisation is not just an economic phenomenon, although it is frequently described as such, but includes commerce, disease and travel, and immigration, and as such it affects blood safety and supply in various ways. The relatively short travel times offered by modern aviation can result in the rapid spread of blood-borne pathogens before measures to counteract transmission can be put in place; this would have happened with SARS if the basic life cycle of the SARS virus included an asymptomatic viraemia. This risk can be amplified by ecological factors which effect the spread of these pathogens once they are transferred to a naïve ecosystem, as happened with West Nile Virus (WNV) in North America. The rationalization and contraction of the plasma products industry may be viewed as one aspect of globalisation imposed by the remorseless inevitability of the market; the effect of this development on the safety and supply of products has yet to be seen, but the oversight and assurance of a shrinking number of players will present particular challenges. Similarly, the monopolization of technology, through patent enforcement which puts access beyond the reach of developing countries, can have an effect on blood safety. The challenges presented to blood safety by globalisation are heightening the tensions between the traditional focus on the product safety - zero risk paradigm and the need to view the delivery of safe blood as an integrated process. As an illustration of this tension, donor deferral measures imposed by globalisation-induced risks such as vCJD and WNV have resulted in the loss of the safest and most committed portion of the blood donor population in many Western countries, leading to an increased risk to

  13. The magnesium reference value in whole blood using nuclear activation

    The aim of the present study is to establish an indicative interval for reference value for Mg in whole blood, using the Absolute Neutron Activation Analysis Technique. The necessity of this measurement is related to the fact that the conventional clinical analysis for Mg quantification is performed using plasma, so there is no reference values established for Mg in whole blood for Brazilian population. Ours results provide information which can help in diagnosis of patients and permit to perform a discussion about the advantages and limitations of using this nuclear methodology in hematological examinations. (author)

  14. A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development

    Sugimoto Masahiko

    2010-07-01

    Full Text Available Abstract Background Development and maintenance of the blood-brain and blood-retinal barrier is critical for the homeostasis of brain and retinal tissue. Despite decades of research our knowledge of the formation and maintenance of the blood-brain (BBB and blood-retinal (BRB barrier is very limited. We have established an in vivo model to study the development and maintenance of these barriers by generating a transgenic zebrafish line that expresses a vitamin D-binding protein fused with enhanced green fluorescent protein (DBP-EGFP in blood plasma, as an endogenous tracer. Results The temporal establishment of the BBB and BRB was examined using this transgenic line and the results were compared with that obtained by injection of fluorescent dyes into the sinus venosus of embryos at various stages of development. We also examined the expression of claudin-5, a component of tight junctions during the first 4 days of development. We observed that the BBB of zebrafish starts to develop by 3 dpf, with expression of claudin-5 in the central arteries preceding it at 2 dpf. The hyaloid vasculature in the zebrafish retina develops a barrier function at 3 dpf, which endows the zebrafish with unique advantages for studying the BRB. Conclusion Zebrafish embryos develop BBB and BRB function simultaneously by 3 dpf, which is regulated by tight junction proteins. The Tg(l-fabp:DBP-EGFP zebrafish will have great advantages in studying development and maintenance of the blood-neural barrier, which is a new application for the widely used vertebrate model.

  15. Thrombocytopenia model with minimal manipulation of blood cells allowing whole blood assessment of platelet function.

    Tiedemann Skipper, Mette; Rubak, Peter; Halfdan Larsen, Ole; Hvas, Anne-Mette

    2016-06-01

    In vitro models of thrombocytopenia are useful research tools. Previously published models have shortcomings altering properties of platelets and other blood components. The aim of the present study was to develop a whole blood method to induce thrombocytopenia with minimal manipulation, and to describe platelet function in induced thrombocytopenia in individuals with healthy platelets. Hirudin anticoagulated blood was obtained from 20 healthy volunteers. One part of the blood was gently centrifuged at 130g for 15 minutes. The platelet-rich plasma was replaced with phosphate-buffered saline to establish thrombocytopenia. Various levels of thrombocytopenia were achieved by combining different volumes of baseline whole blood and thrombocytopenic blood. Platelet counts were measured by flow cytometry (Navios, Beckman Coulter) and routine haematological analyser (Sysmex XE-5000). Platelet function was analysed by impedance aggregometry (Multiplate® Analyzer, Roche) and by flow cytometry (Navios, Beckman Coulter) using collagen, adenosine diphosphate, thrombin receptor activating peptide-6 and ristocetin as agonists. Median baseline platelet count was 227×10(9)/l. The in vitro model yielded median platelet counts at 51×10(9)/l (range 26-93×10(9)/l). We observed minor, yet significant, changes in platelet size and maturity from baseline to modelled thrombocytopenia. In the thrombocytopenic samples, significant and positive linear associations were found between platelet count and platelet aggregation across all agonists (all p-valuesblood-based model of thrombocytopenia was established and validated. This new model serves as a useful future tool, particularly to explore platelet function in patients with thrombocytopenia. PMID:26555800

  16. Cigarette smoking increases white blood cell aggregation in whole blood.

    Bridges, A B; Hill, A; Belch, J J

    1993-01-01

    We studied the effect of chronic cigarette smoking on white blood cell aggregation, increased aggregation predisposes to microvascular occlusion and damage. Current smokers had significantly increased white blood cell aggregation when compared with non smokers. The presence of chronically activated white blood cells in current smokers may be relevant in the pathogenesis of ischaemic vascular disease.

  17. Complete blood count reference intervals for healthy Han Chinese adults.

    Xinzhong Wu

    Full Text Available Complete blood count (CBC reference intervals are important to diagnose diseases, screen blood donors, and assess overall health. However, current reference intervals established by older instruments and technologies and those from American and European populations are not suitable for Chinese samples due to ethnic, dietary, and lifestyle differences. The aim of this multicenter collaborative study was to establish CBC reference intervals for healthy Han Chinese adults.A total of 4,642 healthy individuals (2,136 males and 2,506 females were recruited from six clinical centers in China (Shenyang, Beijing, Shanghai, Guangzhou, Chengdu, and Xi'an. Blood samples collected in K2EDTA anticoagulant tubes were analyzed. Analysis of variance was performed to determine differences in consensus intervals according to the use of data from the combined sample and selected samples.Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers. Red blood cell count (RBC, hemoglobin (HGB, and hematocrit (HCT values were higher in males than in females at all ages. Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference. Thalassemia carriers were found to affect the lower or upper limit of different RBC profiles.We were able to establish consensus intervals for CBC parameters in healthy Han Chinese adults. RBC, HGB, and HCT intervals were established for each sex. The reference interval for platelets for the Chengdu center should be established independently.

  18. Diagnosis of Carrion’s Disease by Direct Blood PCR in Thin Blood Smear Negative Samples

    del Valle Mendoza, Juana; Silva Caso, Wilmer; Tinco Valdez, Carmen; Pons, Maria J.; del Valle, Luis J.; Oré, Verónica Casabona; Michelena, Denisse Champin; Mayra, Jorge Bazán; Gavidea, Víctor Zavaleta; Vargas, Martha; Ruiz, Joaquim

    2014-01-01

    Bartonella bacilliformis is the etiologic agent of Carrion's disease. This disease has two well established phases, the most relevant being the so called Oroya Fever, in which B. bacilliformis infect the erythrocytes resulting in severe anemia and transient immunosuppression, with a high lethality in the absence of adequate antibiotic treatment. The presence of B. bacilliformis was studied in 113 blood samples suspected of Carrion’s disease based on clinical criteria, despite the absence of a...

  19. Blood rheology and aging

    Başkurt, Oğuz K.; Simmonds, Michael J. ; Meiselman, Herbert J.

    2013-01-01

    Journal of Geriatric Cardiology (2013) 10: 291301 ©2013 JGC All rights reserved; www.jgc301.com http://www.jgc301.com; | Journal of Geriatric Cardiology Review  Open Access  Blood rheology and aging Michael J. Simmonds1, Herbert J. Meiselman2, Oguz K. Baskurt3 1Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Gold Coast, QLD 4222, Australia 2Department of Physiology and Biophysics, Keck School of Medicine, University of S...

  20. Human blood glucose dynamics

    Rahaghi, Farbod N.

    2007-01-01

    The control of blood glucose concentration has become central to the prevention of morbidity in diabetes. Currently sensors are becoming available to make available near continuous measurements of tissue glucose concentrations. Frequently measured values provide an opportunity to analyze the dynamics of these measurements in addition to statistical analysis. The dynamics can be used to verify sensor validity, to provide a physiologic control target, and serve as a tool to diagnose and monitor...

  1. Blood Flow Multiscale Phenomena

    Agić, Ante; Mijović, Budimir; Nikolić, Tatjana

    2007-01-01

    The cardiovascular disease is one of most frequent cause deaths in modern society. The objective of this work is analyse the effect of dynamic vascular geometry (curvature, torsion,bifurcation) and pulsatile blood nature on secondary flow, wall shear stress and platelet deposition. The problem was examined as multi-scale physical phenomena using perturbation analysis and numerical modelling. The secondary flow determined as influence pulsatile pressure, vascular tube time-dependen...

  2. India’s first public cord blood repository — looking back and moving forward

    Viswanathan, Chandra; Kabra, Preeti; Nazareth, Vanita; Kulkarni, Manisha; Roy, Arunava

    2009-01-01

    Umbilical cord blood is an established source of stem cells useful for hematopoetic reconstitution. The first clinical transplantation in France by Eliane Gluckman in 1988 using HLA matched umbilical cord blood from a sibling on a 6-year-old boy with Fanconi’s anemia is an example of a successful transplantation. So far, more than 8,000 patients worldwide have been treated for malignant and inherent blood disorders [1, 2]. Our cord blood repository (CBR) was established as the part of the Lif...

  3. Diagnosis of High Blood Pressure

    Full Text Available ... above. Confirming High Blood Pressure A blood pressure test is easy and painless and can be done ... provider’s office or clinic. To prepare for the test: Don’t drink coffee or smoke cigarettes for ...

  4. High blood pressure and diet

    ... this page: //medlineplus.gov/ency/article/007483.htm High blood pressure and diet To use the sharing features on ... diet is a proven way to help control high blood pressure . These changes can also help you lose weight ...

  5. Diagnosis of High Blood Pressure

    Full Text Available ... track blood pressure readings over a period of time, the health care provider may ask you to ... the office on different days and at different times to take your blood pressure. The health care ...

  6. Diagnosis of High Blood Pressure

    Full Text Available ... visit the health care provider, he or she should tell you what your blood pressure numbers are; if he or she does not, you should ask for your readings. Blood Pressure Severity and ...

  7. Know Your Blood Sugar Numbers

    ... with your health care team. What are target blood sugar levels for people with diabetes? A target is something ... gly- see -mee-uh). It means that your blood sugar level is higher than your target level or over ...

  8. What Happens to Donated Blood?

    ... Blood? Step 1: The Donation Donor registers Health history and mini physical are completed About 1 pint of blood and several small test tubes are collected from each donor The bag, test tubes and the donor record are labeled ...

  9. Low blood sugar symptoms (image)

    ... nervousness and irritability are signs that a person's blood sugar is getting dangerously low. A person showing any of these symptoms should check their blood sugar. If the level is low (70 mg/dl), ...

  10. What Causes High Blood Cholesterol?

    ... the NHLBI on Twitter. What Causes High Blood Cholesterol? Many factors can affect the cholesterol levels in your blood. You can control some ... but not others. Factors You Can Control Diet Cholesterol is found in foods that come from animal ...

  11. Aspartate aminotransferase (AST) blood test

    ... Saunders; 2016:chap 73. Read More Acute kidney failure Acute pancreatitis Alanine transaminase (ALT) blood test ALP - blood test Burns Cardiac catheterization Enzyme Heart attack Hemolytic anemia Hepatic Liver cancer - hepatocellular carcinoma Liver disease Mononucleosis Muscular ...

  12. High Blood Pressure in Pregnancy

    ... of the baby. Controlling your blood pressure during pregnancy and getting regular prenatal care are important for ... your baby. Treatments for high blood pressure in pregnancy may include close monitoring of the baby, lifestyle ...

  13. Genes That Influence Blood Pressure

    ... Research Matters NIH Research Matters September 26, 2011 Genes that Influence Blood Pressure In one of the ... 16 previously unknown variations. Six were found in genes already suspected of regulating blood pressure. The remaining ...

  14. Oscillometric blood pressure measurements: A signal analysis

    Barbé, K.; Van Moer, W.; Lauwers, L.

    2010-07-01

    In this paper, the oscillometric waveform measured by automatic non-invasive blood pressure meters (NIBP) is analyzed by transforming the data from the time domain to the frequency domain. The signal's spectrum of the oscillometric waveform is in current literature badly understood or explored. The only known link between the oscillometric waveform and the blood pressure is the maximum of the oscillometry's envelope equalling the mean arterial pressure (MAP). This link is established under the assumption that the oscillometry is an AM-signal. Unfortunately, computing the MAP is difficult in practice due to the non-sinusoidal nature of the actual measured signals. In this paper, we construct the best AM-signal approximation of the oscillometry and explore its use to compute the MAP.

  15. Nursing Education in High Blood Pressure Control. Report of the Task Force on the Role of Nursing in High Blood Pressure Control.

    National Institutes of Health (DHEW), Bethesda, MD. High Blood Pressure Information Center.

    This curriculum guide on high blood pressure (hypertension) for nursing educators has five sections: (1) Introduction and Objectives provides information regarding the establishment and objectives of the National Task Force on the Role of Nursing in High Blood Pressure Control and briefly discusses nursing's role in hypertension control; (2) Goals…

  16. Transfusions of blood and blood products and viral infections

    Marta Wróblewska

    2002-06-01

    Full Text Available Transfusions of blood and blood products are commonly used in medicine, but being biological materials they carry a risk of transmitting infections--viral, bacterial, parasitic, as well as prions. Laboratory tests used for screening of donated blood for viral infections at present cannot detect all infectious units. Criteria for selection of blood donors therefore must be very strict, while methods of inactivation of viruses and laboratory assays for detection of their presence must be improved. Indications for blood transfusion should be restricted.

  17. Ancestry informative markers and complete blood count parameters in Brazilian blood donors

    Gabriela E. S. Felix

    2010-01-01

    Full Text Available A complete blood count is very useful in clinical diagnoses when reference ranges are well established for the population. Complete blood counts and allele frequencies of Ancestry Informative Markers (AIMs were analyzed in Brazilians with the aim of characterizing the hematological values of an admixed population. Positive associations were observed between gender and neutrophils, monocytes, eosinophils, erythrocytes, hemoglobin, hematocrit, MCV, MCHC and platelet counts. No significant differences were found for age, alcohol consumption, educational status, ethnicity, smoking in respect to the complete blood count values. In general, men had higher red blood cell values, while women had higher values for white blood cells and platelets. The study of the population was highly heterogeneous with mean proportions (± SE of African, European and Amerindian ancestry being 49.0 ± 3.0%, 44.0 ± 9.0% and 7.0 ± 9.0%, respectively. Amerindian ancestry showed limited contribution to the makeup of the population, but estimated ancestral proportions were statistically significant (r = 0.9838; P<0.001. These hematologic values are similar to Afro-Americans, another admixed population.

  18. Measurement of limb blood flow using technetium-labelled red blood cells

    Parkin, A; Robinson, P.J.; Wiggins, P.A.; Leveson, S.H.; Salter, M.C.P.; Matthews, I.F.; Ware, F.M.

    1986-05-01

    A method for measuring blood flow below the knee during reactive hyperaemia induced by 3 min of arterial occlusion has been developed. Subjects are positioned with lower limbs within the field of view of a gamma camera and pneumatic cuffs are placed below the knees to isolate the blood and induce a hyperaemic response. The remaining blood pool is labelled with /sup 99/Tcsup(m)-labelled red cells. Blood flows have been derived from the initial gradients of time-activity curves and from equilibrium blood sampling. The technique has been validated using a tissue-equivalent leg phantom and peristaltic pump. The method has been applied to a small group of patients with peripheral vascular disease and to normal controls. The mean value (+-SD) of limb perfusion for normal controls was found to be 16.4 +- 3.0 ml/100 ml/min and for patients with intermittent claudication was 5.1 +- 2.6 ml/100 ml/min. Flow measurements are found to correlate with clinical findings and with symptoms. Reproducibility (established by repeated measurements) is high. The method is well tolerated even by patients suffering from rest pain.

  19. The measurement of limb blood flow using technetium-labelled red blood cells

    A method for measuring blood flow below the knee during reactive hyperaemia induced by 3 min of arterial occlusion has been developed. Subjects are positioned with lower limbs within the field of view of a gamma camera and pneumatic cuffs are placed below the knees to isolate the blood and induce a hyperaemic response. The remaining blood pool is labelled with 99Tcsup(m)-labelled red cells. Blood flows have been derived from the initial gradients of time-activity curves and from equilibrium blood sampling. The technique has been validated using a tissue-equivalent leg phantom and peristaltic pump. The method has been applied to a small group of patients with peripheral vascular disease and to normal controls. The mean value (+-SD) of limb perfusion for normal controls was found to be 16.4+-3.0 ml/100 ml/min and for patients with intermittent claudication was 5.1+-2.6 ml/100 ml/min. Flow measurements are found to correlate with clinical findings and with symptoms. Reproducibility (established by repeated measurements) is high. The method is well tolerated even by patients suffering from rest pain. (author)

  20. Diagnosis of High Blood Pressure

    Full Text Available ... Diagnosis of High Blood Pressure For most patients, health care providers diagnose high blood pressure when blood pressure ... and painless and can be done in a health care provider’s office or clinic. To prepare for the ...

  1. Diagnosis of High Blood Pressure

    Full Text Available ... page from the NHLBI on Twitter. Diagnosis of High Blood Pressure For most patients, health care providers diagnose high ... are consistently 140/90 mmHg or above. Confirming High Blood Pressure A blood pressure test is easy and painless ...

  2. Stroke and High Blood Pressure

    ... Pressure Tools & Resources Stroke More Stroke and High Blood Pressure Updated:Jan 6,2015 Stroke is a leading ... heart disease and stroke. Start exploring today ! High Blood Pressure • Home • About High Blood Pressure (HBP) • Why HBP ...

  3. Living with High Blood Pressure

    ... from the NHLBI on Twitter. Living With High Blood Pressure If you have high blood pressure, the best thing to do is to talk ... care provider and take steps to control your blood pressure by making healthy lifestyle changes and taking medications, ...

  4. Potassium and High Blood Pressure

    ... Pressure Tools & Resources Stroke More Potassium and High Blood Pressure Updated:Mar 1,2016 A diet that includes ... was last reviewed on 08/04/2014. High Blood Pressure • Home • About High Blood Pressure (HBP) • Why HBP ...

  5. Myths about High Blood Pressure

    ... Pressure Tools & Resources Stroke More Myths About High Blood Pressure Updated:Aug 12,2014 You CAN manage your ... was last reviewed on 08/04/2014. High Blood Pressure • Home • About High Blood Pressure (HBP) Introduction What ...

  6. Know Your Blood Sugar Numbers

    Know Your Blood Sugar Numbers If you have diabetes, keeping your blood sugar (glucose) numbers in your target range can help you feel ... Prevention There are two ways to measure blood sugar. 1 The A1C is a lab test that ...

  7. Diagnosis of High Blood Pressure

    Full Text Available ... pressure. Using the results of your blood pressure test, your health care provider will diagnose prehypertension or high blood pressure ... same age, gender, and height . Once your health care provider ... he or she can order additional tests to determine if your blood pressure is due ...

  8. Sero prevalence of hepatitis -C antibodies in blood donors

    Objective: To assess the prevalence of anti HCV antibodies in blood donors. Design: The retrospective sero-epidemiological data of the institute of Hematology and Blood Transfusion Service, Punjab over a period of one year after starting HCV screening, was analyzed to estimate the percentage prevalence. Setting; The data was obtained regularly from the blood units established by this institute at the pablic sector hospitals and retesting on initially reactive serum sample by EIA was done at the Institute. Subjects: A total of 166183 directed first time donors or replacement blood donors aged 18-60 years who donated blood at these blood banks or at mobile sessions have been included in the study. All initially reactive donors who tested non-reactive on EIA were excluded from the study. Main outcome Measures: Assessment of prevalence of HCV in blood donors. Results: 4.45% of the total donors intially tested reactive of these 0.36 % were atsety reactive on intial screening. Further testing by EIA, 4.1%. Conclusions: The blood transfusion service started screening for HCV in April 2000 and the prevalence of HCV, amongst the transfusion transmitted infections (TTIs) being screened for in the Punjab, is the highest. It is almost double the prevalence of HBV and several thousand time that of HIV. Meticulous and total screening coverage is needed to curtail impending catastrophe. With experience, the choice of testing methodology might have to be reviewed. (author)

  9. Blood distribution measurements

    The necessity of employing a vascular exploration technique, which is non-aggressive and repetitive, and which gives total and quantitative results led to the exploitation of a rheo-graphic method. An apparatus was constructed for making such measurements. Some appropriate statistics were subsequently determined which allowed the law concerning the establishment of a circulatory index to be determined as well as its statistical distribution and pathological threshold. The results of an examination, which are presented graphically, led to the establishment of a technique (known as cartography) giving the state of the circulation in a member. The application of this technique to persons affected with arteritis allowed the validity of the law and the previously established thresholds to be verified. The apparatus was completely automated and thus gives results which are entirely objective. (author)

  10. Blood Borne Hepatitis at Hajj

    Harunor Rashid

    2006-06-01

    Full Text Available An pilgrims estimated 2.5 million Muslims from all over the world are expected to converge in Mecca, Saudi Arabia by the end of this December for Hajj pilgrimage. Overcrowding during the largest annual mass gathering of such enormous proportions inevitably increases exposure to and risk of a variety of infections, some with pandemic potential (1. Adopting simple measures and offering appropriate immunisations to the pilgrims can prevent many of these infections. Knowledge of the nature and extent of infections however is important to implement the effective protective measures.As part of the rites of Hajj, men shave their heads although trimming the hair is also acceptable; women cut a lock of their hair. Communal use of razors or blades carries the risk of blood borne infections such as Hepatitis B, hepatitis C or HIV(2. To minimise this risk the Saudi authorities require all barbers looking after the pilgrims to be licensed but many pilgrims use the services of opportunistic makeshift barbers or help by shaving each other, often reusing their razors at the risk of transmitting blood borne virus infections. Unlike the respiratory infections that have a short incubation, infection with blood borne viruses takes much longer to manifest or indeed may remain undetected for many years while it may progress to chronic liver disease.Studies on barbers have shown a high prevalence of carriage and disease among barbers. Extrapolating from various studies Memish et al. (2003 estimated that about 10% of the barbers are carriers of hepatitis C and 4% carry hepatitis B, over a tenth of whom are in active carrier stage (3. Many pilgrims will come from areas of the world with a high endemicity of blood borne infections such as hepatitis B and/or C. To our knowledge there have not been any studies to establish the exact incidence of viral hepatitis among the pilgrims. There is an urgent need to understand the true epidemiology and to measure the burden of

  11. Quantitative blood group typing using surface plasmon resonance.

    Then, Whui Lyn; Aguilar, Marie-Isabel; Garnier, Gil

    2015-11-15

    The accurate and reliable typing of blood groups is essential prior to blood transfusion. While current blood typing methods are well established, results are subjective and heavily reliant on analysis by trained personnel. Techniques for quantifying blood group antibody-antigen interactions are also very limited. Many biosensing systems rely on surface plasmon resonance (SPR) detection to quantify biomolecular interactions. While SPR has been widely used for characterizing antibody-antigen interactions, measuring antibody interactions with whole cells is significantly less common. Previous studies utilized SPR for blood group antigen detection, however, showed poor regeneration causing loss of functionality after a single use. In this study, a fully regenerable, multi-functional platform for quantitative blood group typing via SPR detection is achieved by immobilizing anti-human IgG antibody to the sensor surface, which binds to the Fc region of human IgG antibodies. The surface becomes an interchangeable platform capable of quantifying the blood group interactions between red blood cells (RBCs) and IgG antibodies. As with indirect antiglobulin tests (IAT), which use IgG antibodies for detection, IgG antibodies are initially incubated with RBCs. This facilitates binding to the immobilized monolayer and allows for quantitative blood group detection. Using the D-antigen as an example, a clear distinction between positive (>500 RU) and negative (anti-D IgG. Complete regeneration of the anti-human IgG surface is also successful, showing negligible degradation of the surface after more than 100 regenerations. This novel approach is validated with human-sourced whole blood samples to demonstrate an interesting alternative for quantitative blood grouping using SPR analysis. PMID:26047997

  12. Zinc oxide nanoflowers make new blood vessels

    Barui, Ayan Kumar; Veeriah, Vimal; Mukherjee, Sudip; Manna, Joydeb; Patel, Ajay Kumar; Patra, Sujata; Pal, Krishnendu; Murali, Shruthi; Rana, Rohit K.; Chatterjee, Suvro; Patra, Chitta Ranjan

    2012-11-01

    It is well established that angiogenesis is the process of formation of new capillaries from pre-existing blood vessels. It is a complex process, involving both pro- and anti-angiogenic factors, and plays a significant role in physiological and pathophysiological processes such as embryonic development, atherosclerosis, post-ischemic vascularization of the myocardium, tumor growth and metastasis, rheumatoid arthritis etc. This is the first report of zinc oxide (ZnO) nanoflowers that show significant pro-angiogenic properties (formation of new capillaries from pre-existing blood vessels), observed by in vitro and in vivo angiogenesis assays. The egg yolk angiogenesis assay using ZnO nanoflowers indicates the presence of matured blood vessels formation. Additionally, it helps to promote endothelial cell (EA.hy926 cells) migration in wound healing assays. Formation of reactive oxygen species (ROS), especially hydrogen peroxide (H2O2)--a redox signaling molecule, might be the plausible mechanism for nanoflower-based angiogenesis. Angiogenesis by nanoflowers may provide the basis for the future development of new alternative therapeutic treatment strategies for cardiovascular and ischemic diseases, where angiogenesis plays a significant role.It is well established that angiogenesis is the process of formation of new capillaries from pre-existing blood vessels. It is a complex process, involving both pro- and anti-angiogenic factors, and plays a significant role in physiological and pathophysiological processes such as embryonic development, atherosclerosis, post-ischemic vascularization of the myocardium, tumor growth and metastasis, rheumatoid arthritis etc. This is the first report of zinc oxide (ZnO) nanoflowers that show significant pro-angiogenic properties (formation of new capillaries from pre-existing blood vessels), observed by in vitro and in vivo angiogenesis assays. The egg yolk angiogenesis assay using ZnO nanoflowers indicates the presence of matured blood

  13. Biochemical changes in blood under Cr6+

    Kuzenko E.V.

    2013-01-01

    Full Text Available Background. For the manufacture of dentures many different alloys containing chromium are used. Interaction with oral fluid, organic acids and food, results in formation of Cr3+, Cr6+ ions, but their influence on the whole organism is poorly investigated. Objective. To analyze the biochemical changes in blood plasma during the influence of Cr6+ ions. Methods. 15 animals of experimental group were receiving drinking water with potassium dichromate in a dose of 0,2 mol/l. Rats of control group (5 individuals drank usual drinking water. Animals were led out of experiment on the 20th, 40th and 60th days after the beginning of introduction of potassium dichromate. Results. It was established that at the beginning of experiment the blood biochemical indicators of control and the 1st experimental groups differed by its content. Increase of urea concentration led to suspicion about violation of a glomerular filtration, damage of a kidney parenchyma and tissue disintegration. On the 20th and 40th days of experiment the symptoms of acidosis and increase of potassium ions concentration in blood plasma were defined. Continuous and dynamic increase of creatin-phosphokinase was observed during 60 days of experiment. Conclusion. Biochemical changes in blood under the influence of Cr6+ ions evidence their toxic action on an organism. Especial concern is caused by changes of ionic composition and increase of the atherogenic index of blood plasma on the 40th day of experiment. Substantial increase of the creatin-phosphokinase level indicates general somatic influence of chromium ions.

  14. Blood Pump Bearing System

    Aber, Gregory S. (Inventor)

    2000-01-01

    An apparatus is provided for a blood pump bearing system within a pump housing to support long-term highspeed rotation of a rotor with an impeller blade having a plurality of individual magnets disposed thereon to provide a small radial air gap between the magnets and a stator of less than 0.025 inches. The bearing system may be mounted within a flow straightener, diffuser, or other pump element to support the shaft of a pump rotor. The bearing system includes a zirconia shaft having a radiused end. The radiused end has a first radius selected to be about three times greater than the radius of the zirconia shaft. The radiused end of the zirconia shaft engages a flat sapphire endstone. Due to the relative hardness of these materials a flat is quickly produced during break-in on the zirconia radiused end of precisely the size necessary to support thrust loads whereupon wear substantially ceases. Due to the selection of the first radius, the change in shaft end-play during pump break-in is limited to a total desired end-play of less than about 0.010 inches. Radial loads are supported by an olive hole ring jewel that makes near line contact around the circumference of the Ir shaft to support big speed rotation with little friction. The width of olive hole ring jewel is small to allow heat to conduct through to thereby prevent heat build-up in the bearing. A void defined by the bearing elements may fill with blood that then coagulates within the void. The coagulated blood is then conformed to the shape of the bearing surfaces.

  15. Radiolabelled Cellular Blood Elements

    This volume contains the abstracts of the 5th International Symposion on Radiolabelling of Cellular Blood Elements to be held in Vienna, Austria, September 10-14, 1989. The Meeting is the fifth in a series of meetings designed to discuss the basics and clinical application of radiolabelling techniques. In these days, beside the search for new labelling agents and extending the knowledge in clinical use, the use of monoclonal antibodies is a big new challenge. All reviewed contributions that have been accepted for presentation are contained in this volume. (authors) 58 of them are of INIS scope

  16. Development of blood irradiators

    Over a period of several years, a small, fully portable blood irradiator has been developed for ultimate use in suppressing early rejection of organ transplants in humans. It could also be useful for other medical problems, e.g., treating some forms of leukemia or arthritis. The units have been successfully evaluated in several animal species, resulting in sharply reduced lymphocyte levels and prolonged skin-graft retention. Work during the past year was directed toward development of hardware in anticipation of kidney transplant studies, to be performed in dogs in FY 1982, and identifying whether dose fractionation significantly changed lymphocyte response

  17. Doppler blood flow indicator

    Byrtus, David

    2014-01-01

    This bachelor´s thesis deals with basis of ultra-acoustics. The project presents basic information about Doppler effect. It describes the methods of processing and analyzing of velocity and direction of blood at doppler’s systems with modulated and unmodulated carrier wave. The project presents the system design of non-directional doppler indicator with unmodulated carrier wave for 8 MHz frequency, generating intensity of ultrasound 100 mW/cm2 and diameter D-shaped transmitting transducer 8 m...

  18. Establishing of Quality Assurance System of VATESI

    Decision to establish VATESI quality assurance system (QAS) was made in October 2000. QAS aims and procedures to be improved are listed. Description of the plan how QAS will be established is presented. VATESI counts on Finland's assistance in training on document management and developing safety regulations

  19. Establishing Quality Assurance System of VATESI

    Decision to establish VATESI quality assurance system (QAS) was made in October 2000. Experts representing Licensing Assistance Project countries have been providing support in establishing the QAS, especially specialists from France, Sweden. QAS aims and procedures to be improved are listed. In 2002 two procedures were drafted: Inspections and enforcement measures and Safety assessment

  20. ORANGE JUICE AND BLOOD PRESSURE

    M. F. VALIM

    2009-01-01

    Full Text Available

    Blood pressure is the force of blood against artery walls. It is measured in millimeters of mercury (mm Hg and recorded as two numbers: systolic pressure (as the heart contracts over diastolic pressure (as the heart relaxes between beats. High blood pressure (hypertension is defined as chronically elevated high blood pressure, with systolic blood pressure (SBP of 140 mm Hg or greater, and diastolic blood pressure (DBP of 90 mm Hg or greater. High blood pressure (HBP, smoking, abnormal blood lipid levels, obesity and diabetes are risk factors for coronary heart disease, the leading cause of death in the US. Lifestyle modifications such as engaging in regular physical activity, quitting smoking and eating a healthy diet (limiting intake of saturated fat and sodium and increasing consumption of fiber, fruits and vegetables are advocated for the prevention, treatment, and control of HBP. As multiple factors influence blood pressure, the effects of each factor are typically modest, particularly in normotensive subjects, yet the combined effects can be substantial. Nutrition plays an important role in influencing blood pressure. Orange juice should be included as part of any low sodium diet and/or any blood pressure reducing eating plan, as it is sodium free, fat-free and can help meet recommended levels of potassium intake that may contribute to lower BP.

  1. Blood donor management in china.

    Shi, Ling; Wang, Jingxing; Liu, Zhong; Stevens, Lori; Sadler, Andrew; Ness, Paul; Shan, Hua

    2014-07-01

    Despite a steady increase in total blood collections and voluntary non-remunerated blood donors, China continues to have many challenges with its blood donation system. The country's donation rate remains low at 9%o, with over 60% of donors being first-time donors. Generally there is a lack of adequate public awareness about blood donation. The conservative donor selection criteria, the relatively long donation interval, and the small donation volume have further limited blood supply. To ensure a sufficient and safe blood supply that meets the increasing clinical need for blood products, there is an urgent need to strengthen the country's blood donor management. This comprehensive effort should include educating and motivating more individuals especially from the rural areas to be involved in blood donation, developing rational and evidence-based selection criteria for donor eligibility, designing a donor follow-up mechanism to encourage more future donations, assessing the current donor testing strategy, improving donor service and care, building regional and national shared donor deferral database, and enhancing the transparency of the blood donation system to gain more trust from the general public. The purpose of the review is to provide an overview of the key process of and challenges with the blood donor management system in China. PMID:25254023

  2. Blood transfusion economics in Greece.

    Kyriopoulos, J E; Michail-Merianou, V; Gitona, M

    1995-01-01

    This paper describes the organizational structure and the economic impact of blood donation and transfusion in Greece and discusses some alternative aspects of its financing and its costing policy. The cost of blood transfusion is rising in Greece and amounts to nearly 15 billion drachmas per year due to the constant increase in demand and consequently, the price of each unit of blood. The production and distribution of blood on national scale involves meeting the demand for 500.000 units. Blood is mostly given by the friends and relatives of patients (55%) and by voluntary blood donation (30%). Approximately 50% of the blood produced is used in surgery, 20% for cases of beta-thalassaemia, 10% for emergencies and 20% for internal medicine cases. The blood transfusion system is totally funded by the state budget and the value to users is free of charge. The way in which blood is collected and processed differs from one geographical area to another and the unit cost depends on the size of the department concerned, ranging from 60-150 $. The need to control costs and restrain expenditure, in conjunction with guarantees of sufficiency and quality, makes it essential that measures should be taken to introduce economies of scale and encourage competition among blood providers, for increased production, components preparation and rational usage of blood. The introduction of a costing policy becomes necessary in this effort to achieve cost-containment techniques. PMID:8581182

  3. How to monitor blood glucose.

    Dunning, Trisha

    2016-01-27

    Rationale and key points Capillary blood glucose monitoring is an essential component of diabetes care. Blood glucose tests provide important information about how the body is controlling blood glucose metabolism, and the effect of glucose-lowering medicines, illness and stress. ▶ The nurse should consider the rationale for testing blood glucose each time they perform a test, and reflect on the result, taking into consideration the patient's blood glucose target range and recommended care guidelines. ▶ Blood glucose testing times and testing frequency should be planned to suit the glucose-lowering medicine regimen and the clinical situation. Reflective activity Clinical skills articles can help update your practice and ensure it remains evidence based. Apply this article to your practice. Reflect on and write a short account of: 1. What you have gained from this article. 2. How this article will influence your practice when monitoring blood glucose. Subscribers can upload their reflective accounts at: rcni.com/portfolio . PMID:26967884

  4. New blood flow radiopharmaceutical

    Our program for research into the causes of mental disorders such as schizophrenia, manic depressive illness and senile dementia has led us to the development of a new radiopharmaceutical agent, IDNNA (4-iodo-2,5-dimethoxy-N,N-dimethylamphetamine). A series of some 15 different 131I labeled molecules with various substitutions on the amine were synthesized and tested, and the uptake of the 131I labeled conpounds in rats was measured. The dimethyl amine (IDNNA) had the best brain uptake and brain/blood ratio. When injected into a dog and scanned with a whole-body scanner, the uptake in the brain could be clearly seen and quantified. Plasma sampling at the same time showed that the maximum brain/blood ratio of 8.7 occurred at 8 min after injection, and the concentration in brain remained high for at least 15 min. Labeling is achieved by reacting 131ICl and the precursor, 2,5-dimethoxy-N,N-dimethyl amphetamine, in glacial acetic acid; the reaction is complete in less than one minute

  5. Quality control for handling of accidental blood exposures.

    Wijk, P.T. van; Pelk-Jongen, M.; Wijkmans, C.; Voss, A.; Schneeberger, P.M.

    2006-01-01

    A regional counselling service was established to handle all accidental blood exposures using a standardized protocol. Levels of risk were assessed using an algorithm. Accidents that posed a risk for the transmission of hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV) were

  6. Sodium intake and blood pressure in renal transplant recipients

    van den Berg, Else; Geleijnse, Johanna M.; Brink, Elizabeth J.; van Baak, Marleen A.; van der Heide, Jaap J. Homan; Gans, Rijk O. B.; Navis, Gerjan; Bakker, Stephan J. L.

    2012-01-01

    Hypertension is common among renal transplant recipients (RTR) and a risk factor for graft failure and mortality. Sodium intake is a well-established determinant of blood pressure (BP) in the general population. However, data in RTR are limited. International guidelines recommend a maximum daily sod

  7. Sodium intake and blood pressure in renal transplant recipients

    Berg, van den E.; Geleijnse, J.M.; Brink, E.J.; Baak, van M.A.; Homan van der Heide, van der J.J.; Gans, R.O.B.; Navis, G.; Bakker, S.J.L.

    2012-01-01

    Background - Hypertension is common among renal transplant recipients (RTR) and a risk factor for graft failure and mortality. Sodium intake is a well-established determinant of blood pressure (BP) in the general population. However, data in RTR are limited. International guidelines recommend a maxi

  8. Establishing a model of supratentorial hemorrhage in the piglet

    The most common site of hemorrhage is the basal ganglia, which exhibits the obvious neurological deficits. In the present study, we aimed to develop a model of supratentorial intracerebral hemorrhage (ICH) with neurological deficits in piglets (6.0 to 8.8 kg). A pediatric urinary catheter with two passages and one balloon was introduced through a burr hole into the right striatum. All the animals received balloon inflation, which was performed by injecting 2.5 ml saline into the balloon through one passage. Then each piglet in experimental group (n=18) received an injection of 1.0-ml autologous arterial blood through the other passage over 2 min and maintained for 5 min. Then, additional 1.5-ml blood was injected over 15 min. Piglets in control group (n=6) received only balloon inflation without blood injection. CT scanning was performed immediately after surgery. A deep hematoma was successfully induced in 16 out of 18 piglets and the hematoma volume was 1.74±0.22 ml (n=5) at 24 hours after surgery. All the piglets with hematoma had behavioral deficits (lame or could not walk) at 24 hours. Tissue damages, such as cell swelling, necrosis and demyelination, appeared at 24 hours in the brain tissues, adjacent to the hematoma, and was aggravated at 48 hours and ameliorated at 7 days after hematoma induction. In conclusion, we have established a simple model of supratentorial ICH in piglets with marked neurological deficits, which is suitable for study of the pathophysiology and treatment of ICH. (author)

  9. Establishment of a Learning Management System

    A web-based learning management system (LMS) has been established to address the need of customized education and training of Nuclear Training Center (NTC) of KAERI. The LMS is designed to deal with various learning types (e.g. on-line, off-line and blended) and a practically comprehensive learning activity cycle (e.g. course preparation, registration, learning, and postlearning) as well as to be user-friendly. A test with an example course scenario on the established system has shown its satisfactory performance. This paper discusses details of the established webbased learning management system in terms of development approach and functions of the LMS

  10. [Blood donation in urban areas].

    Charpentier, F

    2013-05-01

    Medical and technical developments increase the difficulty to provide sufficient safe blood for all patients in developed countries and their sociodemographic and societal changes. Sufficient national blood supply remains a reached, however still actual, challenge. Tomorrow is prepared today: the management of blood donation programs both in line with these developments and with social marketing strategies is one of the keys to success. If the main components of this organization are well known (mobile blood drives in various appropriate environments, and permanent blood donation centers) their proportions in the whole process must evolve and their contents require adaptations, especially for whole blood donation in urban areas. We have to focus on the people's way of life changes related to increasing urbanization of the society and prominent position taken by very large cities. This requires targeting several goals: to draw the attention of the potential blood-giving candidate, to get into position to collect him when he will decide it, to give meaning and recognition to his "sacrifice" (give time rather than donate blood) and to give him desire and opportunity to come back and donate one more time. In this strategy, permanent blood centers in urban areas have significant potential for whole blood collection, highlighted by the decrease of apheresis technology requirements. This potential requires profound changes in their location, conception and organization. The concept of Maison Du Don (MDD) reflects these changes. PMID:23597586

  11. Cadmium in blood and hypertension

    Eum, Ki-Do; Lee, Mi-Sun [Department of Environmental Health, Graduate School of Public Health and Institute of Health and Environment, Seoul National University, Seoul (Korea, Republic of); Paek, Domyung [Department of Environmental Health, Graduate School of Public Health and Institute of Health and Environment, Seoul National University, Seoul (Korea, Republic of)], E-mail: paekdm@snu.ac.kr

    2008-12-15

    Objectives:: This study is to examine the effect of cadmium exposure on blood pressure in Korean general population. Methods:: The study population consisted of 958 men and 944 women who participated in the 2005 Korean National Health and Nutrition Examination Survey (KNHANES), in which blood pressure and blood cadmium were measured from each participant. Results:: The mean blood cadmium level was 1.67 {mu}g/L (median level 1.55). The prevalence of hypertension was 26.2%. The blood cadmium level was significantly higher among those subjects with hypertension than those without (mean level 1.77 versus 1.64 {mu}g/dL). After adjusting for covariates, the odds ratio of hypertension comparing the highest to the lowest tertile of cadmium in blood was 1.51 (95% confidence interval 1.13 to 2.05), and a dose-response relationship was observed. Systolic, diastolic, and mean arterial blood pressure were all positively associated with blood cadmium level, and this effect of cadmium on blood pressure was markedly stronger when the kidney function was reduced. Conclusions:: Cadmium exposures at the current level may have increased the blood pressure of Korean general population.

  12. Cadmium in blood and hypertension

    Objectives:: This study is to examine the effect of cadmium exposure on blood pressure in Korean general population. Methods:: The study population consisted of 958 men and 944 women who participated in the 2005 Korean National Health and Nutrition Examination Survey (KNHANES), in which blood pressure and blood cadmium were measured from each participant. Results:: The mean blood cadmium level was 1.67 μg/L (median level 1.55). The prevalence of hypertension was 26.2%. The blood cadmium level was significantly higher among those subjects with hypertension than those without (mean level 1.77 versus 1.64 μg/dL). After adjusting for covariates, the odds ratio of hypertension comparing the highest to the lowest tertile of cadmium in blood was 1.51 (95% confidence interval 1.13 to 2.05), and a dose-response relationship was observed. Systolic, diastolic, and mean arterial blood pressure were all positively associated with blood cadmium level, and this effect of cadmium on blood pressure was markedly stronger when the kidney function was reduced. Conclusions:: Cadmium exposures at the current level may have increased the blood pressure of Korean general population

  13. Viral metagenomics and blood safety.

    Sauvage, V; Eloit, M

    2016-02-01

    The characterization of the human blood-associated viral community (also called blood virome) is essential for epidemiological surveillance and to anticipate new potential threats for blood transfusion safety. Currently, the risk of blood-borne agent transmission of well-known viruses (HBV, HCV, HIV and HTLV) can be considered as under control in high-resource countries. However, other viruses unknown or unsuspected may be transmitted to recipients by blood-derived products. This is particularly relevant considering that a significant proportion of transfused patients are immunocompromised and more frequently subjected to fatal outcomes. Several measures to prevent transfusion transmission of unknown viruses have been implemented including the exclusion of at-risk donors, leukocyte reduction of donor blood, and physicochemical treatment of the different blood components. However, up to now there is no universal method for pathogen inactivation, which would be applicable for all types of blood components and, equally effective for all viral families. In addition, among available inactivation procedures of viral genomes, some of them are recognized to be less effective on non-enveloped viruses, and inadequate to inactivate higher viral titers in plasma pools or derivatives. Given this, there is the need to implement new methodologies for the discovery of unknown viruses that may affect blood transfusion. Viral metagenomics combined with High Throughput Sequencing appears as a promising approach for the identification and global surveillance of new and/or unexpected viruses that could impair blood transfusion safety. PMID:26778104

  14. Risk Factors for High Blood Pressure

    ... the NHLBI on Twitter. Risk Factors for High Blood Pressure Anyone can develop high blood pressure; however, age, ... can increase your risk for developing high blood pressure. Age Blood pressure tends to rise with age. About 65 ...

  15. Blood Pressure Matters: Keep Hypertension in Check

    ... cuff, or an automatic device may measure the pressure. Blood pressure is given as 2 numbers. The first ... described above. High Blood Pressure NIHSeniorHealth: High Blood Pressure High Blood Pressure and Kidney Disease Heart and Vascular Diseases ...

  16. Healthy Blood Pressure: "It's Worth the Effort!"

    ... please turn Javascript on. Special Section: Healthy Blood Pressure Healthy Blood Pressure: "It's worth the effort!" Past Issues / Winter 2010 ... Numbers: What They Mean / Treatment: Types of Blood Pressure Medications / Healthy Blood Pressure: "It's worth the effort!" / Keep the Beat ...

  17. High blood pressure and eye disease

    ... page: //medlineplus.gov/ency/article/000999.htm High blood pressure and eye disease To use the sharing features ... are sent to the brain. Causes High blood pressure can damage blood vessels in the retina. The higher the blood ...

  18. When Blood Sugar Is Too High

    ... Can I Help a Friend Who Cuts? When Blood Sugar Is Too High KidsHealth > For Teens > When Blood ... it often can be unhealthy. What Is High Blood Sugar? The blood glucose level is the amount of ...

  19. Middle cerebral artery blood velocity during rowing

    Secher, Niels Henry; Pott, F; Knudsen, L.;

    1997-01-01

    original,arterial blood pressure,central venous pressure,cerebral blood flow, exercise, transcranial Doppler......original,arterial blood pressure,central venous pressure,cerebral blood flow, exercise, transcranial Doppler...

  20. Code development of the national hemovigilance system and expansion strategies for hospital blood banks

    Kim Jeongeun

    2012-01-01

    Full Text Available Objectives : The aims of this study were to develop reportable event codes that are applicable to the national hemovigilance systems for hospital blood banks, and to present expansion strategies for the blood banks. Materials and Methods : The data were obtained from a literature review and expert consultation, followed by adding to and revising the established hemovigilance code system and guidelines to develop reportable event codes for hospital blood banks. The Medical Error Reporting System-Transfusion Medicine developed in the US and other codes of reportable events were added to the Korean version of the Biologic Products Deviation Report (BPDR developed by the Korean Red Cross Blood Safety Administration, then using these codes, mapping work was conducted. We deduced outcomes suitable for practice, referred to the results of the advisory councils, and conducted a survey with experts and blood banks practitioners. Results : We developed reportable event codes that were applicable to hospital blood banks and could cover blood safety - from blood product safety to blood transfusion safety - and also presented expansion strategies for hospital blood banks. Conclusion : It was necessary to add 10 major categories to the blood transfusion safety stage and 97 reportable event codes to the blood safety stage. Contextualized solutions were presented on 9 categories of expansion strategies of hemovigilance system for the hospital blood banks.

  1. Mechanisms Linking Red Blood Cell Disorders and Cardiovascular Diseases

    Ioana Mozos

    2015-01-01

    Full Text Available The present paper aims to review the main pathophysiological links between red blood cell disorders and cardiovascular diseases, provides a brief description of the latest studies in this area, and considers implications for clinical practice and therapy. Anemia is associated with a special risk in proatherosclerotic conditions and heart disease and became a new therapeutic target. Guidelines must be updated for the management of patients with red blood cell disorders and cardiovascular diseases, and targets for hemoglobin level should be established. Risk scores in several cardiovascular diseases should include red blood cell count and RDW. Complete blood count and hemorheological parameters represent useful, inexpensive, widely available tools for the management and prognosis of patients with coronary heart disease, heart failure, hypertension, arrhythmias, and stroke. Hypoxia and iron accumulation cause the most important cardiovascular effects of sickle cell disease and thalassemia. Patients with congenital chronic hemolytic anemia undergoing splenectomy should be monitored, considering thromboembolic and cardiovascular risk.

  2. Transfusion management of patients with red blood cell antibodies

    Bujandrić Nevenka B.

    2013-01-01

    Full Text Available Introduction. Red blood cell antibodies may cause a positive result of pre-transfusion blood compatibility testing (crossmatch test. It can be a problem to provide suitable blood units for patients with clinically significant antibodies to high-frequency antigens as well as for those with multiple alloantibody specificities. This study was aimed at identifying transfused patients in the population of South-Backa who had developed clinically significant red blood cell alloantibodies. Material and methods. We analyzed the records of crossmatch results and antibody screening performed at the Blood Transfusion Institute of Vojvodina during 2012. Results. Antibodies were found in 103 patients: A 63 patients with single antibodies: 1 16 with antibodies of unknown specificity (3 autoantibodies, 13 alloantibodies; 2 39 with clinically significant antibodies (23 from Rh system (2 anti-C, 2 anti-D, 12 anti-E, 7 anti-c, 4 anti-K, 3 anti-Fya, 7 anti-Jka, 2 anti-S; 3 8 with usually not significant antibodies (6 anti-M, 1 anti-A1, 1 anti- Cw; B 40 patients developed multiple antibodies: 1 all patients had at least one clinically significant antibody from various blood group system (44 Rh, 13 Kell, 7 Kidd, 7 MNSs (S, s; 2 3 patients had usually not significant antibodies (1 Lewis, 2 Lutheran; 3 3 patients occasionally had clinically significant antibody (3 anti- Yta; 4 3 patients had antibodies of unknown specificity (2 autoantibodies, 1alloantibody. Antibodies detected in the majority of patients (65-63.1% had a specificity of Rh and/or the Kell system. Conclusions. The main goal of pre-transfusion blood compatibility testing is to detect clinically significant antibodies. The provision of antigen negative blood units for those patients is a special challenge for blood establishments. Database with a sufficient number of typed blood donors can help to resolve this problem.

  3. Sufficient blood, safe blood: can we have both?

    Bönig Halvard

    2012-03-01

    Full Text Available Abstract The decision in September 2011 in the UK to accept blood donations from non-practicing men who have sex with men (MSM has received significant public attention. Will this rule change substantially boost the number of blood donations or will it make our blood less safe? Clearly, most European countries have a blood procurement problem. Fewer young people are donating, while the population is aging and more invasive therapies are requiring more blood. Yet if that was the reason for allowing non-practicing MSM to donate, clearly re-admission of some other, much larger populations that are currently deferred from donation should likewise be considered. As far as risks for blood safety are concerned, evidence has been provided that the current quality of infectious disease marker testing significantly mitigates against, although does not completely eradicate, risks associated with admission of donors with a high risk of carrying certain blood-transmissible agents. However, it could be argued that more effective recruitment of the non-donor pool, which is substantially larger than the group of currently ineligible donors, would be a better strategy. Recruitment of this group will benefit the availability of blood without jeopardizing the current excellent safety profile of blood.

  4. Effect of blood storage and nutrient medium on the yield of chromosome aberrations under subsequent X-irradiation

    Conducted are cytogenetic investigations on studing of chromosomal aberrations frequency depending on storage time (0, 24, 48, 72 h) of nonirradiated and X-irradiated blood and nutrient medium in glass and plastic vessels at the temperature of 20 deg C. It is established that it is not advisable to store blood in plastic vessels for biological dosimetry purposes. It is recommended to use either fresh blood or blood stored in vessels from neutral glass

  5. Time to positivity in blood cultures of adults with Streptococcus pneumoniae bacteremia

    Ansorena Luis; Garrido Jose; Rodríguez-Lera María; Peralta Galo; Roiz María

    2006-01-01

    Abstract Background previous studies have established that bacterial blood concentration is related with clinical outcome. Time to positivity of blood cultures (TTP) has relationship with bacterial blood concentration and could be related with prognosis. As there is scarce information about the usefulness of TTP, we study the relationship of TTP with clinical parameters in patients with Streptococcus pneumoniae bacteremia. Methods TTP of all cases of Streptococcus pneumoniae bacteremia, detec...

  6. Growth capacity of thermotolerant campylobacters in culture media supplemented with pig and cow blood

    Álvaro Tresierra-Ayala; Manuel Navas; Josué Flores; Ramsés Perea; Juan Huanaquiri; María Bendayán; Heriberto Fernández

    2010-01-01

    In this work 60 thermotolerant Campylobacter strains (37 C. jejuni and 23 C. coli) isolated from the cows, pigs, chickens and ducks (15 strains of each type of animal) were used to establish their growth capacity on media containing cow or swine blood as potential substitutes of sheep or horse blood. The growth capacity was assessed by viable counts on cow and swine blood media, using the modified Miles and Misra method. Campylobacter strains showed better growth in the media supplemented wit...

  7. Measurement of interaction forces between red blood cells in aggregates by optical tweezers

    Maklygin, A Yu; Priezzhev, A V; Karmenian, A; Nikitin, Sergei Yu; Obolenskii, I S; Lugovtsov, Andrei E; Kisun Li

    2012-06-30

    We have fabricated double-beam optical tweezers and demonstrated the possibility of their use for measuring the interaction forces between red blood cells (erythrocytes). It has been established experimentally that prolonged trapping of red blood cells in a tightly focused laser beam does not cause any visible changes in their shape or size. We have measured the interaction between red blood cells in the aggregate, deformed by optical tweezers.

  8. [Establishment of Arapaho National Wildlife Refuge

    US Fish and Wildlife Service, Department of the Interior — This document contains information relating to the establishment of Arapaho NWR. It contains 1 letter to the house of representatives stating the approval for the...

  9. Food Service Establishment Inspections: Beginning 2005 (ACTIVE)

    U.S. Department of Health & Human Services — This data includes the name and location of active food service establishments and the violations that were found at the time of the inspection. Active food service...

  10. [Marketing in the world of blood donation].

    Daigneault, Sylvie

    2007-05-01

    Public and non-profit organizations have long debated how marketing concepts and management styles apply to their sector of activity as they are largely derived from principles of consumerism and economic decision-making proper to the private sector. The arrival of marketing in the world of blood donation is no exception. The purpose of this article is to illustrate concretely how marketing techniques can contribute in achieving the objectives of a blood donation program: a marketing model that is adapted to the realities of blood donation in Quebec. Although types of marketing are as varied as the fields they are used in, the major marketing activities of this program fall under positioning, operational or relationship marketing. The process is presented in the form of a cycle that includes four major phases containing all marketing functions, that is, raising public awareness, acquiring a clientele, client retention and loyalty building, and establishing the relationship. Finally, the information and effective management of information are at the heart of the marketing process. In fact, research, understanding our customers and their expectations, and measuring our performance are essential for the success of any marketing initiative. PMID:17524694

  11. Red blood cell in simple shear flow

    Chien, Wei; Hew, Yayu; Chen, Yeng-Long

    2013-03-01

    The dynamics of red blood cells (RBC) in blood flow is critical for oxygen transport, and it also influences inflammation (white blood cells), thrombosis (platelets), and circulatory tumor migration. The physical properties of a RBC can be captured by modeling RBC as lipid membrane linked to a cytoskeletal spectrin network that encapsulates cytoplasm rich in hemoglobin, with bi-concave equilibrium shape. Depending on the shear force, RBC elasticity, membrane viscosity, and cytoplasm viscosity, RBC can undergo tumbling, tank-treading, or oscillatory motion. We investigate the dynamic state diagram of RBC in shear and pressure-driven flow using a combined immersed boundary-lattice Boltzmann method with a multi-scale RBC model that accurately captures the experimentally established RBC force-deformation relation. It is found that the tumbling (TU) to tank-treading (TT) transition occurs as shear rate increases for cytoplasm/outer fluid viscosity ratio smaller than 0.67. The TU frequency is found to be half of the TT frequency, in agreement with experiment observations. Larger viscosity ratios lead to the disappearance of stable TT phase and unstable complex dynamics, including the oscillation of the symmetry axis of the bi-concave shape perpendicular to the flow direction. The dependence on RBC bending rigidity, shear modulus, the order of membrane spectrin network and fluid field in the unstable region will also be discussed.

  12. Establishment of reference standards in biosimilar studies

    2013-01-01

    When an innovative biological product goes off-patent, biopharmaceutical or biotechnological companies may file an application for regulatory approval of biosimilar products. In practice, however, important information on the innovative (reference) product may not be available for assessment. Thus, it is important to first establish a reference standard while assessing biosimilarity between a biosimilar product and the reference product. In this paper, reference standard is established throug...

  13. Establishment of a Statistical Consulting Business

    S.M. Seeletse

    2001-01-01

    In establishing a statistical consultancy, the baseline is that it is a service business organisation that is being established. The essentials of a business should be incorporated, as well as the set of skills that are being marketed and sold In particular, skills in the discipline of statistics are a definite prerequisite. It also helps to understand the requirements of consulting. Knowledge of marketing and selling is also required. Competitive edge is important for sustainability within t...

  14. Effects of cultural diversity on individual establishments

    Brunow, Stephan; Blien, Uwe

    2011-01-01

    International immigration affects the degree of cultural diversity present in a labour force. This paper focuses on the consequences of immigration with respect to the level of cultural diversity by estimating employment functions for individual establishments. The theory behind the empirical analyses is based on a 'turned around' New Economic Geography model. The data basis used is a linked employer -- employee data set generated by a fusion of the IAB Establishment Panel with the Employment...

  15. An elapsed time-temperature monitor for blood storage.

    Harris, G E; Cloud, S; Myhre, B A

    1977-01-01

    Blood should not be allowed to exceed 10 C while being stored or transported. However, one cannot test the internal temperature of a unit of blood without contaminating it. Most blood banks have established an arbitrary time limit beyond which a blood unit cannot be kept out of the refrigerator. This method is ineffective if blood is stored in a satellite refrigerator, since the blood may be moved in and out of the refrigerator and the blood bank personnel will be unaware of it. An elapsed time indicator is described which employs a small condenser (E-Cell-Plessey Electronics) charged with a known amount of electricity. If the device is removed from the refrigerator, it begins to discharge at a known rate. The amount of time subsequently can be determined by the loss of charge. The prototype of this instrument has been found to be quite accurate and small (2 inches X 2 inches X 1 inch). It would be rather inexpensive if made in considerable numbers. PMID:867474

  16. Tumor Blood Vessel Dynamics

    Munn, Lance

    2009-11-01

    ``Normalization'' of tumor blood vessels has shown promise to improve the efficacy of chemotherapeutics. In theory, anti-angiogenic drugs targeting endothelial VEGF signaling can improve vessel network structure and function, enhancing the transport of subsequent cytotoxic drugs to cancer cells. In practice, the effects are unpredictable, with varying levels of success. The predominant effects of anti-VEGF therapies are decreased vessel leakiness (hydraulic conductivity), decreased vessel diameters and pruning of the immature vessel network. It is thought that each of these can influence perfusion of the vessel network, inducing flow in regions that were previously sluggish or stagnant. Unfortunately, when anti-VEGF therapies affect vessel structure and function, the changes are dynamic and overlapping in time, and it has been difficult to identify a consistent and predictable normalization ``window'' during which perfusion and subsequent drug delivery is optimal. This is largely due to the non-linearity in the system, and the inability to distinguish the effects of decreased vessel leakiness from those due to network structural changes in clinical trials or animal studies. We have developed a mathematical model to calculate blood flow in complex tumor networks imaged by two-photon microscopy. The model incorporates the necessary and sufficient components for addressing the problem of normalization of tumor vasculature: i) lattice-Boltzmann calculations of the full flow field within the vasculature and within the tissue, ii) diffusion and convection of soluble species such as oxygen or drugs within vessels and the tissue domain, iii) distinct and spatially-resolved vessel hydraulic conductivities and permeabilities for each species, iv) erythrocyte particles advecting in the flow and delivering oxygen with real oxygen release kinetics, v) shear stress-mediated vascular remodeling. This model, guided by multi-parameter intravital imaging of tumor vessel structure

  17. Effect of a whole-body gamma irradiation on glycemia and ATP blood level in rats

    An attempt was made to establish possible correlations, during gamma irradiation, between glucose and ATP. The variations in their blood levels were studied, using specific enzymatic methods. The results obtained after a low dose irradiation (150 roentgens) demonstrated an increase of glycemia during the hours following the irradiation and a parallel decrease of ATP blood level

  18. 78 FR 54257 - Advisory Council on Blood Stem Cell Transplantation; Request for Nominations for Voting Members

    2013-09-03

    ... was established to implement a statutory requirement of the Stem Cell Therapeutic and Research Act of... regarding research on emerging therapies using cells from bone marrow and cord blood. The ACBSCT consists of... HUMAN SERVICES Health Resources and Services Administration Advisory Council on Blood Stem...

  19. Establishing community trust at radioactively contaminated sites

    Establishing community trust is an essential element in the successful remediation of a radioactively contaminated site. The US Environmental Protection Agency (EPA), Region 2 has been involved in the clean up of numerous radioactively contaminated Comprehensive Environmental Response, Compensation and Liability Act (CERCLA), Resource Conservation Recovery Act (RCRA), and Formerly Utilized Site Remedial Action Program (FUSRAP) sites in New Jersey and New York. Each site presented a unique challenge which centered around establishing and, often, re-establishing the trust of the surrounding community. Thanks to the United States government's history regarding the use of radioactive materials, people question whether governmental regulators could possibly have the public's best interests in mind when it comes to addressing radioactively contaminated sites. It has been our experience that EPA can use its position as guardian of the environment to help establish public confidence in remedial actions. The EPA can even use its position to lend credibility to remedial activities in situations where it is not directly responsible for the clean-up. Some ways that we have found to instill community confidence are: establishing radioanalytical cross-check programs using EPA's National Air and Radiation Environmental Laboratory to provide analytical quality assurance; and establishing an environmental radiation monitoring program for the contaminated site and surrounding community. (author)

  20. Blood mixtures: impact of puncture site on blood parameters.

    Bonnet, X; El Hassani, M S; Lecq, S; Michel, C L; El Mouden, E H; Michaud, B; Slimani, T

    2016-08-01

    Various puncture routes, veins, arteries, heart, are used to take blood in animals. For anatomical reasons, differences in blood composition are expected among puncture sites. However, this issue has been rarely assessed and contrasted results have been reported: strong effects of puncture site versus a lack of effect. We captured free-ranging freshwater turtles from different locations to compare the mean concentrations of 12 blood parameters (metabolites, hormone, ions, and enzyme) among three puncture sites: (1) a lateral branch of the jugular vein, (2) a dorsal subcarapacial cervical plexus (sometimes incorrectly referred as the 'cervical sinus' in the literature), and (3) a caudal plexus site (sometimes incorrectly referred as the 'caudal sinus'). Because we used very small syringes (27-30G), we were able to separate lymph, blood, or blood-lymph mixtures. Our results show very strong effects of puncture site and of mixture level (mean maximal difference between sites was 250 %). We also found strong sex and geographical effects. Typically, there were differences in concentrations of blood solutes sampled from the lateral jugular vein and subcarapacial plexus, mainly due to sampling a mixture of blood and lymph from the 'blood' at the subcarapacial site and pure blood from the lateral jugular site, and likewise, samples from the caudal site were highly variable due to often sampling a mixture of blood and lymph. These results have technical and fundamental implications, especially when performing comparative analyses. Further, by selecting precise puncture sites, physiological differences between lymph and blood compartments could be investigated. PMID:27146147

  1. Establishment of extracorporeal circulation of artificial liver support system in high altitude region

    Ming-sen ZHANG

    2011-01-01

    Full Text Available Objective To establish extracorporeal circulation in big animal suitable for the research on artificial liver support system in high altitude region.Methods Under the anesthesia of ketamine hydrochloride/diazepam IV,cannulation of common carotid artery/external jugular vein(n=3 and inferior vena cava via the left external jugular vein/right external jugular vein(n=3,was respectively performed on six healthy Chang-Bai piglets adapted to native environment(altitude 3700m.One day after that,the extracorporeal circulation was performed at a progressively elevated blood current velocity,and the general condition of the animals,blood pressure,HR,bleeding tendoncy of the experimental pigs and coagulation in the cannulae were observed.Results On the premise that the hemodynamics was not influenced,the highest blood current velocity was 133.33±28.87ml/min,the lowest heparin maintaining speed amounted to 138.67±12.22mg/h,and the bleeding tendency and blood coagulation in the cannula was significant in the group of common carotid artery/external jugular vein intubation.While the highest blood current velocity was 400ml/min,the lowest heparin maintaining speed was 26.67±9.24mg/h,no bleeding tendency or obvious cannular blood coagulation were observed in the group of cannulation of inferior vena cava via the left external jugular vein/right external jugular vein.These untoward results were significantly less or slight than that of the former group(P < 0.01.Conclusion It is suitable to perform research of artificial liver support system on piglets in high altitude region by establishing extracorporeal circulation by the way of inferior vena cava with cannulation passing through the left external jugular vein/right external jugular vein with the blood current velocity of 400ml/min.

  2. Blood-brain barrier and blood-cerebrospinal fluid barrier in normal and pathological conditions.

    Ueno, Masaki; Chiba, Yoichi; Murakami, Ryuta; Matsumoto, Koichi; Kawauchi, Machi; Fujihara, Ryuji

    2016-04-01

    Blood-borne substances can invade into the extracellular spaces of the brain via endothelial cells in sites without the blood-brain barrier (BBB), and can travel through the interstitial fluid (ISF) of the brain parenchyma adjacent to non-BBB sites. It has been shown that cerebrospinal fluid (CSF) drains directly into the blood via the arachnoid villi and also into lymph nodes via the subarachnoid spaces of the brain, while ISF drains into the cervical lymph nodes through perivascular drainage pathways. In addition, the glymphatic pathway of fluids, characterized by para-arterial pathways, aquaporin4-dependent passage through astroglial cytoplasm, interstitial spaces, and paravenous routes, has been established. Meningeal lymphatic vessels along the superior sagittal sinus were very recently discovered. It is known that, in mice, blood-borne substances can be transferred to areas with intact BBB function, such as the medial regions of the hippocampus, presumably through leaky vessels in non-BBB sites. In the present paper, we review the clearance mechanisms of interstitial substances, such as amyloid-β peptides, as well as summarize models of BBB deterioration in response to different types of insults, including acute ischemia followed by reperfusion, hypertension, and chronic hypoperfusion. Lastly, we discuss the relationship between perivascular clearance and brain disorders. PMID:26920424

  3. Dengue viremia in blood donors in Northern India: Challenges of emerging dengue outbreaks to blood transfusion safety

    Sadhana Mangwana

    2015-01-01

    Full Text Available Backdround: Emerging infectious diseases pose threats to the general human population; including recipients of blood transfusions. Dengue is spreading rapidly to new areas and with increasing frequency of major outbreaks. Screening blood for dengue antigens in dengue-endemic countries would be costly and should, therefore, be recommended only after careful assessment of risk for infection and cost. Aim: A prospective study was conducted to establish the magnitude of the threat that dengue poses to blood safety where it is sporadic with seasonal variations, to quantify risk and to assess that whether screening is feasible and cost-effective. Materials and Methods: Nonstructural protein 1 (NS1 antigen test was done on 1709 donations during dengue outbreak in the months August to November 2013 as an additional test using Bio-Rad Platelia Dengue NS1AG test kit which is one step sandwich format microplate enzyme immunoassay using murine monoclonal antibodies for capture and revelation. Chi-square test was used to find statistical significance. Results and Conclusions: Majority cases were whole blood, replacement, male donors with 76.10% donors in <35 years age group. About 17.85% were single donor platelet donations. NS1 antigen in all donors was negative. In the past, dengue affected mainly children who do not donate blood. With the changing trend, mean age of infection increased affecting the population that does donate blood, further reducing blood donation pool. Further studies need to be done in different geographic regions of the country during dengue transmission season to establish maximum incidence of viremic donations, rates of transfusion transmission and clinical consequences in recipients. If risk is found to be substantial, decision will be taken by the policymakers at what threshold screening should be instituted to ensure safe blood transfusion.

  4. Cerebral blood flow velocities after subarachnoid haemorrhage in relation to the amount of blood clots in the initial computed tomography

    In 72 patients with acute subarachnoid haemorrhage (SAH) the relationship between the amount of subarachnoid blood clots detected by initial cranial computed tomography (CCT) up to 48 hours after bleeding and the later development of vasospasm, established by blood flow velocity measurement with transcranial Doppler ultrasound (TCD) was investigated. The serial Doppler examinations started within the first 72 hours after SAH and were carried out every second day up to three weeks. Each Doppler recording was accompanied by a neurological examination. Patients classified as Hunt and Hess grade V were excluded from the study. All patients with remarkable brain oedema in CCT or with intracranial pressure above 25 mmHg were also excluded. Because of the well known agedependence of vasospasm after SAH, two age groups were formed. A statistically significant correlation (p > 0.05) between blood flow velocities and blood load after SAH was not found. The mean age of the investigated 72 individuals was 48.9 years (14 up to 76 years). 47 patients were younger than 56 years. Linear regression analysis indicated a correlation with a quite low significance level (r = 0.350, p 0.05) between these two variables could be established in the 25 patients older than 55 years. In a second step an intra-individual comparison of side-to-side differences in TCD and CCT was made. There were no significant differences in blood flow velocities between subjects with or without side-to-side differences in cisternal blood load. It is concluded that the amount of blood visible on initial CCT after SAH is not a powerful predictor of cerebral blood flow velocities measured by TCD. (author)

  5. The blood-tendon barrier: identification and characterisation of a novel tissue barrier in tendon blood vessels.

    Lehner, C; Gehwolf, R; Ek, J C; Korntner, S; Bauer, H; Bauer, H C; Traweger, A; Tempfer, H

    2016-01-01

    Tissue barriers function as "gate keepers" between different compartments (usually blood and tissue) and are formed by specialised membrane-associated proteins, localising to the apicolateral plasma membrane domain of epithelial and endothelial cells. By sealing the paracellular space, the free diffusion of solutes and molecules across epithelia and endothelia is impeded. Thereby, tissue barriers contribute to the establishment and maintenance of a distinct internal and external environment, which is crucial during organ development and allows maintenance of an organ-specific homeostatic milieu. So far, various epithelial and endothelial tissue barriers have been described, including the blood-brain barrier, the blood-retina barrier, the blood-testis barrier, the blood-placenta barrier, and the cerebrospinal fluid (CSF)-brain barrier, which are vital for physiological function and any disturbance of these barriers can result in severe organ damage or even death. Here, we describe the identification of a novel barrier, located in the vascular bed of tendons, which we term the blood-tendon barrier (BTB). By using immunohistochemistry, transmission electron microscopy, and tracer studies we demonstrate the presence of a functional endothelial barrier within tendons restricting the passage of large blood-borne molecules into the surrounding tendon tissue. We further provide in vitro evidence that the BTB potentially contributes to the creation of a distinct internal tissue environment impacting upon the proliferation and differentiation of tendon-resident cells, effects which might be fundamental for the onset of tendon pathologies. PMID:27227787

  6. Whole blood pathogen reduction technology and blood safety in sub-Saharan Africa: A systematic review with regional discussion

    Asa'ah Nkohkwo

    2016-02-01

    Full Text Available Background: Despite vast improvements in transfusion services in sub-Saharan Africa over the last decade, there remain serious concerns on the safety and adequacy of the blood supply across the region.Objective: This review paper ascertains the role of pathogen reduction technology (PRT in improving blood safety and supply adequacy in the region.Method: The state of blood safety in sub-Saharan Africa was reviewed. Meetings, seminars and correspondence were undertaken with key clinicians, scientists and professional bodies in the region, including the World Health Organization’s Regional Office for Africa, to examine the suitability of PRT for improving the safety of whole blood transfusion, a prevalent transfusion format in the region.Results: Existing literature suggests that combining PRT with current blood safety measures (such as serology would improve the safety and adequacy of the blood supply for transfusions in sub-Saharan Africa. This was echoed by the findings of the stakeholder meetings.Conclusion: Following a detailed appraisal of two leading PRT systems, the Mirasol® PRT System and the Cerus S-303 System, we suggest that companies conduct comprehensive toxicological evaluation of the agents used for PRT and publish this in the scientific literature. We also recommend that the safety and efficacy of these technologies should be established in a randomised clinical trial conducted in sub-Saharan Africa.Keywords: Pathogen Reduction/ Inactivation, Transfusion-Transmitted Infections, Blood Safety, Sub-Saharan Africa

  7. Establishment of unilateral renovascular hypertension in dogs and mark monitoring

    Objective: To evaluate the efficacy of the renovascular hypertension model by cannula ligation of unilateral renal artery of dogs. Methods: The experimental animals (dogs) were divided randomly into four groups including normal control group, stenosis control group, nephrectomy group and renal arterial embolization group. The unilateral renal arteries of latter three groups were ligated. The mean arterial pressure was obtained by measuring through carotid artery sheath. The authors estimate and discuss the established hypertension by monitoring marker-blood pressure, renin-angiotensin, creatinine, urea and angiography. Results: Normal control group mean arterial pressure and other groups normal mean arterial pressure (before ligating operation) were (142.5 +- 2.6)/(87.6 +- 2.5) mmHg. After ligation within one to three days, the mean arterial pressure began to elevate and after six days reached a steady high level [(195.6 +- 14.7)/(135.6 +- 10.5) mmHg. After ligation the mean arterial pressure of dogs was significant higher than the normal (P < 0.01). The average stenotic degree of renal artery was more than 80% in angiography. Conclusions: To establish renovascular hypertension experimental animal model by cannula ligation of unilateral renal artery is feasible simulating that in human being, easy for reduplication are success

  8. Establishment of selected acute pulmonary thromboembolism model in experimental sheep

    Objective: To establish a selected acute pulmonary thromboembolism model in experimental sheep suitable for animal experiment. Methods: By using Seldinger's technique the catheter sheath was placed in both the femoral vein and femoral artery in ten sheep. Under C-arm DSA guidance the catheter was inserted through the catheter sheath into the pulmonary artery. Via the catheter appropriate amount of sheep autologous blood clots was injected into the selected pulmonary arteries. The selected acute pulmonary thromboembolism model was thus established. Pulmonary angiography was performed to check the results. The pulmonary arterial pressure, femoral artery pressure,heart rates and partial pressure of oxygen in arterial blood (PaO2) were determined both before and after the treatment. The above parameters obtained after the procedure were compared with the recorded parameters measured before the procedure, and the sheep model quality was evaluated. Results: The baseline of pulmonary arterial pressure was (27.30 ± 9.58) mmHg,femoral artery pressure was (126.4 ± 13.72) mmHg, heart rate was (103 ± 15) bpm and PaO2 was (87.7 ± 12.04) mmHg. Sixty minutes after the injection of (30 ± 5) ml thrombotic agglomerates, the pulmonary arterial pressures rose to (52 ± 49) mmHg, femoral artery pressures dropped to (100 ± 21) mmHg. The heart rates went up to (150 ± 26) bpm. The PaO2 fell to (25.3 ± 11.2) mmHg. After the procedure the above parameters were significantly different from that measured before the procedure in all ten animals (P < 0.01). The pulmonary arteriography clearly demonstrated that the selected pulmonary arteries were successfully embolized. Conclusion: The anatomy of sheep's femoral veins,vena cava system, pulmonary artery and right heart system are suitable for the establishment of the catheter passage, for this reason, selected acute pulmonary thromboembolism model can be easily created in experimental sheep. The technique is feasible and the model has

  9. Chapter 19. Blood and bone marrow. C. Blood platelet kinetics

    The blood platelet life span was measured by labelling the circulating population in vivo and in vitro. DF32P labelling in vivo: DFP is a specific inhibitor of acetyl-cholinesterase and hence in vivo labels blood platelets in the same way as the red cells and white cells which contain this enzyme. Sodium chromate 51Cr: this is the method used almost universally and the various stages were described. Several parameters were studied: the percentage of blood platelets in circulation, the aspect of the radioactivity decay curve, blood platelet production. Results obtained by the use of a medulla tracer, 75Se selenomethionine, were also reported. Finally the practical use of the blood platelet kinetics measurements were demonstrated

  10. Establishment and Operation of User Facilities

    PEFP(Proton Engineering Frontier Project) has launched on a new enterprise to develop the technologies for the future relating to the proton beam and spin-off technologies in 2002. PEFP planned to supply 20MeV and 100MeV proton beam by the development of the 100MeV, 20mA linear accelerator during ten years from 2002 to 2012. The final goal of this project is establishment of 20MeV and 100MeV user facilities. To do this, we must develop the key technologies for establishing user facilities. Before the main facilities are normally operated, we have established the test user facilities to support various kinds of users' basic experiments and pilot studies. The necessity of this research are as follows; - Domestic achievement of key technologies for the development and design of the user facilities for the several tens to hundreds MeV class high current proton beam - Beam application researches can be revitalized and improved the efficiency by the establishment and operation of user facilities and test facilities. - Ion implantation facilities have contributed to increase Industrial applications - It is more effective in saving money that users use the PEFP's user facility than other country's user facilities. - It is possible to contribute to the local society and commercialize the beam application technologies by the establishment of PEFP's research branch in Kyungju

  11. Purpose and Criteria for Blood Smear Scan, Blood Smear Examination, and Blood Smear Review

    Gulati, Gene; Song, Jinming; Florea, Alina Dulau; Gong, Jerald

    2012-01-01

    A microscopic examination of an appropriately prepared and well-stained blood smear by a knowledgeable laboratory professional is necessary and clinically useful in a number of circumstances and for a variety of reasons. In this article, an attempt is made to delineate the purpose and criteria for blood smear examination in a variety of circumstances that are encountered in everyday laboratory hematology practice. A blood smear scan serves to at least (a) verify the flagged automated hematolo...

  12. Good manufacturing practices (GMP utilized on human blood irradiation process

    Cláudio Boghi

    2008-01-01

    Full Text Available Irradiation of human blood is used to avoid the TA-GVHD (transfusion-associated graft-versus-host-disease, a rare but devastating adverse effect of leukocytes present in blood components for immunocompetent transfusion recipients. Usually this irradiation practice is performed to a physical elimination of lymphocytes. The implementation of the GMP will assure that the properly dose in a range of 25Gy to 50Gy will be delivered to the blood in the bag collected in a blood tissue bank. The studies to establish the GMP were developed under the guidelines of the standard ISO 11137 - Sterilization of health care products - Requirements for validation and routine control - Radiation sterilization. In this work, two dosimetric systems were used for dose mapping during the studies of irradiator qualification, loading pattern, irradiation process validation and auditing. The CaSO4: Dy dosimeter presented difficulties concerning to uncertainty on dose measurement, stability, trace ability and calibration system. The PMMA and gafchromic dosimetric systems have shown a better performance and were adopted on establishment of GMP procedures. The irradiation tests have been done using a Gammacell 220 Irradiator. The developed GMP can be adapted for different types of gamma irradiators, allowing to set up a quality assurance program for blood irradiation.

  13. Implementation of good manufacturing practices (GMP) on human blood irradiation

    Boghi, Claudio; Napolitano, Celia M.; Ferreira, Danilo C.; Rela, Paulo Roberto [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)]. E-mails: cboghi@uol.com.br; cmnapoli@ipen.br; dancarde@ig.com.br; prela@ipen.br; Zarate, Herman S. [Comission Chilena de Energia Nuclear, Santiago (Chile)]. E-mail: hzarate@cchen.cl

    2007-07-01

    The irradiation of human blood is used to avoid the TA-GVHD (transfusion-associated graft-versus-host-disease), a rare but devastating adverse effect of leukocytes present in blood components for a immuno-competent transfusion recipients. Usually this irradiation practice is performed to a physical elimination of lymphocytes. The implementation of the GMP will assure that the properly dose in a range of 25 Gy to 50 Gy will be delivered to the blood in the bag collected in a blood tissue bank. The studies to establish the GMP were developed under the guidelines of the standard ISO 11137 - Sterilization of health care products - Requirements for validation and routine control - Radiation sterilization. In this work, two dosimetric systems were used for dose mapping during the studies of irradiator qualification, loading pattern, irradiation process validation and auditing. The CaSO{sub 4}: Dy dosimeter presented difficulties concerning to uncertainty on dose measurement, stability, trace ability and calibration system. The PMMA and gafchromic dosimetric systems have shown a better performance and were adopted on establishment of GMP procedures. The irradiation tests have been done using a Gammacell 220 Irradiator. The developed GMP can be adapted for different types of gamma irradiators, allowing to set up a quality assurance program for blood irradiation. (author)

  14. Implementation of good manufacturing practices (GMP) on human blood irradiation

    The irradiation of human blood is used to avoid the TA-GVHD (transfusion-associated graft-versus-host-disease), a rare but devastating adverse effect of leukocytes present in blood components for a immuno-competent transfusion recipients. Usually this irradiation practice is performed to a physical elimination of lymphocytes. The implementation of the GMP will assure that the properly dose in a range of 25 Gy to 50 Gy will be delivered to the blood in the bag collected in a blood tissue bank. The studies to establish the GMP were developed under the guidelines of the standard ISO 11137 - Sterilization of health care products - Requirements for validation and routine control - Radiation sterilization. In this work, two dosimetric systems were used for dose mapping during the studies of irradiator qualification, loading pattern, irradiation process validation and auditing. The CaSO4: Dy dosimeter presented difficulties concerning to uncertainty on dose measurement, stability, trace ability and calibration system. The PMMA and gafchromic dosimetric systems have shown a better performance and were adopted on establishment of GMP procedures. The irradiation tests have been done using a Gammacell 220 Irradiator. The developed GMP can be adapted for different types of gamma irradiators, allowing to set up a quality assurance program for blood irradiation. (author)

  15. Establishment for quality control of experimental animal

    Until now, because we have imported experimental animal from foreign experimental animal corporation, we could have saved money by establishing the quality control of animal in barrier system. In order to improve the quality of animal experiment and efficiency of biomedical study, it is indispensable to control many factors that effect in the experiment. Therefore, it is essential to organize the system of laboratory animal care for enhancing reliability and revivability of experimental results. The purpose of the present investigation was to establish the quality control system of experimental animals that we can provide good quality animals according to the experimental condition of each investigator although the exact quality control system to estimate the infection of bacteria and virus easily remains ill-defined yet. Accordingly, we established the useful quality control system for microbiologic monitoring and environmental monitoring to protect experimental animal from harmful bacteria and virus

  16. Establishment for quality control of experimental animal

    Kim, Tae Hwan; Kim, Soo Kwan; Kim, Tae Kyoung

    1999-06-01

    Until now, because we have imported experimental animal from foreign experimental animal corporation, we could have saved money by establishing the quality control of animal in barrier system. In order to improve the quality of animal experiment and efficiency of biomedical study, it is indispensable to control many factors that effect in the experiment. Therefore, it is essential to organize the system of laboratory animal care for enhancing reliability and revivability of experimental results. The purpose of the present investigation was to establish the quality control system of experimental animals that we can provide good quality animals according to the experimental condition of each investigator although the exact quality control system to estimate the infection of bacteria and virus easily remains ill-defined yet. Accordingly, we established the useful quality control system for microbiologic monitoring and environmental monitoring to protect experimental animal from harmful bacteria and virus.

  17. Establishing a Comprehensive Wind Energy Program

    Fleeter, Sanford [Purdue University

    2012-09-30

    This project was directed at establishing a comprehensive wind energy program in Indiana, including both educational and research components. A graduate/undergraduate course ME-514 - Fundamentals of Wind Energy has been established and offered and an interactive prediction of VAWT performance developed. Vertical axis wind turbines for education and research have been acquired, instrumented and installed on the roof top of a building on the Calumet campus and at West Lafayette (Kepner Lab). Computational Fluid Dynamics (CFD) calculations have been performed to simulate these urban wind environments. Also, modal dynamic testing of the West Lafayette VAWT has been performed and a novel horizontal axis design initiated. The 50-meter meteorological tower data obtained at the Purdue Beck Agricultural Research Center have been analyzed and the Purdue Reconfigurable Micro Wind Farm established and simulations directed at the investigation of wind farm configurations initiated. The virtual wind turbine and wind turbine farm simulation in the Visualization Lab has been initiated.

  18. Highly sensitive detection of Staphylococcus aureus directly from patient blood.

    Padmapriya P Banada

    Full Text Available BACKGROUND: Rapid detection of bloodstream infections (BSIs can be lifesaving. We investigated the sample processing and assay parameters necessary for highly-sensitive detection of bloodstream bacteria, using Staphylococcus aureus as a model pathogen and an automated fluidic sample processing-polymerase chain reaction (PCR platform as a model diagnostic system. METHODOLOGY/PRINCIPAL FINDINGS: We compared a short 128 bp amplicon hemi-nested PCR and a relatively shorter 79 bp amplicon nested PCR targeting the S. aureus nuc and sodA genes, respectively. The sodA nested assay showed an enhanced limit of detection (LOD of 5 genomic copies per reaction or 10 colony forming units (CFU per ml blood over 50 copies per reaction or 50 CFU/ml for the nuc assay. To establish optimal extraction protocols, we investigated the relative abundance of the bacteria in different components of the blood (white blood cells (WBCs, plasma or whole blood, using the above assays. The blood samples were obtained from the patients who were culture positive for S. aureus. Whole blood resulted in maximum PCR positives with sodA assay (90% positive as opposed to cell-associated bacteria (in WBCs (71% samples positive or free bacterial DNA in plasma (62.5% samples positive. Both the assays were further tested for direct detection of S. aureus in patient whole blood samples that were contemporaneous culture positive. S. aureus was detected in 40/45 of culture-positive patients (sensitivity 89%, 95% CI 0.75-0.96 and 0/59 negative controls with the sodA assay (specificity 100%, 95% CI 0.92-1. CONCLUSIONS: We have demonstrated a highly sensitive two-hour assay for detection of sepsis causing bacteria like S. aureus directly in 1 ml of whole blood, without the need for blood culture.

  19. [Toxicologic blood emergency screening].

    Cohen, Sabine; Manat, Aurélie; Dumont, Benoit; Bévalot, Fabien; Manchon, Monique; Berny, Claudette

    2010-01-01

    In order to overcome the stop marketing by Biorad company of automated high performance liquid chromatograph with UV detection (Remedi), we developed a gas chromatography-mass spectrometry (GC-MS) to detect and to give an approximation of the overdose of molecules frequently encountered in drug intoxications. Therefore two hundred eighty seventeen blood samples were collected over a period of one year and allowed us to evaluate and compare the performance of these two techniques. As identification, GC-MS does not identify all molecules detected by Remedi in 24.2% of cases; there is a lack of sensitivity for opiates and the systematic absence of certain molecules such as betablockers. However, in 75.8% of cases the GC-MS detects all molecules found by Remedi and other molecules such as meprobamate, paracetamol, benzodiazepines and phenobarbital. The concentrations obtained are interpreted in terms of overdose showed 15.7% of discrepancy and 84.3% of concordance between the two techniques. The GC-MS technique described here is robust, fast and relatively simple to implement; the identification is facilitated by macro commands and the semi quantification remains manual. Despite a sequence of cleaning the column after each sample, carryover of a sample to the next remains possible. This technique can be used for toxicologic screening in acute intoxications. Nevertheless it must be supplemented by a HPLC with UV detection if molecules such as betablockers are suspected. PMID:20348049

  20. Blood Test: Lead (For Parents)

    ... Things to Know About Zika & Pregnancy Blood Test: Lead KidsHealth > For Parents > Blood Test: Lead Print A A A Text Size What's in ... Análisis de sangre: plomo What It Is A lead test is used to determine the amount of ...

  1. Diagnosis of High Blood Pressure

    Full Text Available ... does not, you should ask for your readings. Blood Pressure Severity and Type Your health care provider usually takes 2–3 ... any other location. Health care providers diagnose this type of high blood pressure by reviewing readings in the office and ...

  2. BIOMATERIALS FOR ROTARY BLOOD PUMPS

    VANOEVEREN, W

    1995-01-01

    Rotary blood pumps are used for cardiac assist and cardiopulmonary support since mechanical blood damage is less than with conventional roller pumps. The high shear rate in the rotary pump and the reduced anticoagulation of the patient during prolonged pumping enforces high demands on the biocompati

  3. Diabetes and blood pressure (image)

    People with diabetes have a higher risk for heart attacks and strokes. Your doctor or nurse should check your blood pressure ... People with diabetes have a higher risk for heart attacks and strokes. Your doctor or nurse should check your blood pressure ...

  4. High Blood Pressure in Pregnancy

    ... Talk to your doctor about any over-the-counter medications you are taking or are thinking about taking. Does Hypertension or Preeclampsia During Pregnancy Cause Long-Term Heart and Blood Vessel Problems? The effects of high blood pressure during pregnancy vary depending on the disorder and ...

  5. Local Control of Blood Flow

    Clifford, Philip S.

    2011-01-01

    Organ blood flow is determined by perfusion pressure and vasomotor tone in the resistance vessels of the organ. Local factors that regulate vasomotor tone include myogenic and metabolic autoregulation, flow-mediated and conducted responses, and vasoactive substances released from red blood cells. The relative importance of each of these factors…

  6. Diagnosis of High Blood Pressure

    Full Text Available ... Entire Site Health Topics News & Resources Intramural Research Public Health Topics Education & Awareness Resources Contact The Health Information ... Contact Us FAQs Home » Health Information for the Public » Health Topics » High Blood Pressure » Diagnosis of High Blood ...

  7. Classification of positive blood cultures

    Gradel, Kim Oren; Knudsen, Jenny Dahl; Arpi, Magnus;

    2012-01-01

    ABSTRACT: BACKGROUND: Information from blood cultures is utilized for infection control, public health surveillance, and clinical outcome research. This information can be enriched by physicians assessments of positive blood cultures, which are, however, often available from selected patient groups...... or pathogens only. The aim of this work was to determine whether patients with positive blood cultures can be classified effectively for outcome research in epidemiological studies by the use of administrative data and computer algorithms, taking physicians assessments as reference. METHODS: Physicians...... assessments of positive blood cultures were routinely recorded at two Danish hospitals from 2006 through 2008. The physicians assessments classified positive blood cultures as: a) contamination or bloodstream infection; b) bloodstream infection as mono- or polymicrobial; c) bloodstream infection as community...

  8. Autologous blood storage in obstetrics.

    Herbert, W N; Owen, H G; Collins, M L

    1988-08-01

    Autologous transfusion, storage of one's own blood for subsequent infusion if needed, is safe and effective in a variety of scheduled operative procedures. Obstetric involvement in such programs is very limited, however. Thirty pregnant women with placenta previa or other potential complications underwent 55 phlebotomies in an autologous transfusion program. Phlebotomies were performed at an average gestational age of 32.4 weeks (range 13-40). Changes in mean diastolic blood pressure and pulse were minimal. Electronic fetal monitoring tracings were normal during the 34 procedures in which it was used. The frequency of mild donor reactions (4%) was consistent with that in nonpregnant donors. After entry into this program, 15 patients received a total of 29 U of packed red blood cells (23 autologous; six homologous). Homologous transfusion was avoided in 86.7% of patients receiving blood. Selected pregnant women can participate safely in autologous blood collection programs, minimizing the need, and therefore the risks, of homologous transfusion. PMID:3292974

  9. Gastric mucosal blood flow measurement

    Pertechnetate clearance (C/sub Tc/) by the stomach before and after betazole stimulation was compared to regional measurements of gastric blood flow utilizing nuclide (Chromium-51 and Cerium-141)-labeled microspheres in five piglets. Pertechnetate clearance closely correlated (correlation coefficient 0.926) with mucosal blood flow in the gastric corpus measured by the microsphere technique. Betazole increased blood flow in the corpus region by 100 percent but did not alter this relationship. Except in one experiment, microsphere blood flow valves in the antrum and fundus were unchanged by betazole and did not significantly correlate with pertechnetate clearance. Pertechnetate clearance appears to be a reliable method of determining gastric mucosal blood flow in experimental animals and may be considered as a noninvasive method for measuring such flow in humans. (U.S.)

  10. Establishment of a local psychiatric service

    Wang, A G

    1981-01-01

    The Faroe Islands are a group of islands in the North Atlantic Ocean between Norway and Iceland inhabited by about 42,000 people. They are considered a nation with home rule within the Danish Kingdom. A Psychiatric Department was not established on the islands until 1969. Before this, psychiatric...

  11. Establishing rigour in qualitative radiography research

    Murphy, F.J. [School of Healthcare Professions, University of Salford, Salford M6 6PU (United Kingdom)], E-mail: f.j.murphy@salford.ac.uk; Yielder, J. [Medical Imaging, School of Health Sciences, Unitec, Auckland (New Zealand)

    2010-02-15

    The vast majority of radiography research is subject to critique and evaluation from peers in order to justify the method and the outcome of the study. Within the quantitative domain, which the majority of medical imaging publications tend to fall into, there are prescribed methods for establishing scientific rigour and quality in order to critique a study. However, researchers within the qualitative paradigm, which is a developing area of radiography research, are often unclear about the most appropriate methods to measure the rigour (standards and quality) of a research study. This article considers the issues related to rigour, reliability and validity within qualitative research. The concepts of reliability and validity are briefly discussed within traditional positivism and then the attempts to use these terms as a measure of quality within qualitative research are explored. Alternative methods for research rigour in interpretive research (meanings and emotions) are suggested in order to compliment the existing radiography framework that exists for qualitative studies. The authors propose the use of an established model that is adapted to reflect the iterative process of qualitative research. Although a mechanistic approach to establishing rigour is rejected by many qualitative researchers, it is argued that a guide for novice researchers within a developing research base such as radiography is appropriate in order to establish the credibility and trustworthiness of a qualitative study.

  12. 40 CFR 255.30 - Responsibilities established.

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Responsibilities established. 255.30 Section 255.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... waste should be an identified responsibility throughout the State. In the event that no local...

  13. Establishing rigour in qualitative radiography research

    The vast majority of radiography research is subject to critique and evaluation from peers in order to justify the method and the outcome of the study. Within the quantitative domain, which the majority of medical imaging publications tend to fall into, there are prescribed methods for establishing scientific rigour and quality in order to critique a study. However, researchers within the qualitative paradigm, which is a developing area of radiography research, are often unclear about the most appropriate methods to measure the rigour (standards and quality) of a research study. This article considers the issues related to rigour, reliability and validity within qualitative research. The concepts of reliability and validity are briefly discussed within traditional positivism and then the attempts to use these terms as a measure of quality within qualitative research are explored. Alternative methods for research rigour in interpretive research (meanings and emotions) are suggested in order to compliment the existing radiography framework that exists for qualitative studies. The authors propose the use of an established model that is adapted to reflect the iterative process of qualitative research. Although a mechanistic approach to establishing rigour is rejected by many qualitative researchers, it is argued that a guide for novice researchers within a developing research base such as radiography is appropriate in order to establish the credibility and trustworthiness of a qualitative study.

  14. CNPC Hong Kong (Holdings) Ltd. Established

    Wu Yaowen; Yang Hanfeng

    1997-01-01

    @@ On the occasion of the return of Hong Kong to the motherland, CNPC Hong Kong (Holdings) Ltd. is formally established in April, 1997 in Hong Kong. This important event marks the beginning of a new and prosperous stage in the trade and economic cooperation currently forged between the mainland petroleum industry and Hong Kong's financial,industrial and commercial circles.

  15. China's High Performance Computer Standard Commission Established

    2007-01-01

    @@ China's High Performance Computer Standard Commission was established on March 28, 2007, under the guidance of the Science and Technology Bureau of the Ministry of Information Industry. It will prepare relevant professional standards on high performance computers to break through the monopoly in the field by foreign manufacturers and vendors.

  16. China Establishes First Space Debris Observation Center

    HeYing

    2005-01-01

    At the beginning of March 2005, China established its first space debris observation center, Space Object and Debris Observation and Research Center of the Chinese Academy of Sciences (CAS) at the CAS Purple Mountain Observatory (PMO) in Nanjing, Jiangsu Province. The center would set up an earlywarning system for China's space flight.

  17. Blood composition of the reindeer . II. Blood chemistry

    Mauri Nieminen; Jouni Timisjärvi

    1983-01-01

    The blood chemical composition of 578 semi-domestic reindeer were investigated in respect to age, season, calving and nutrition in Northern Finland during 1973-79. The weight gain was maximally 400 g/day at an age of 4-8 weeks as also reflected by high serum thyroxine (T4), alkaline phosphatase (SAP), creatine phosphokinase (CPK) and blood glucose values. Low SAP activity in winter indicated a cessation of growth. The pH of the venous blood was 7.35 and the clotting activity very high (21 sec...

  18. Ratio of blood serum ferritin and ferritin-bearing lymphocytes in breast cancer

    The ratio of the blood serum ferritin level and the amount of ferritin-bearing lymphocytes was determined in breast cancer patients and mastopathy patients. Direct relation between a rise of blood serum ferritin concentration, a drop in the amount of ferritin-bearing cells and tumor spreading was established in breast cancer. The maximum amount of ferritin-bearing cells was present in the blood of the patients with Stage I-IIA disease. Radical mastectomy in such patients returned the blood serum ferritin level and the amount of ferritin-bearing cells to normal

  19. Improvements of Surgical Technique in Establishment of Rat Orthotopic Pulmonary Transplantation Model Using Cuffs

    2006-01-01

    In order to establish more simple and effective rat orthotopic lung transplantation models, 20 rats were divided into donor and recipient groups. Rat lung transplantation models were established by using improved cuff technique. All the 10 operations were accomplished successfully.The mean operative time of recipients was 45±4 min. The survival time was over 30 days after lung transplantation. The checks of X-ray were almost ncrmal. There was no significant difference in the blood gas analysis before and after clipping the right hilum (P>. 05). This method is more simple,applicable and requires less time.

  20. Microfluidic Devices for Blood Fractionation

    Chwee Teck Lim

    2011-07-01

    Full Text Available Blood, a complex biological fluid, comprises 45% cellular components suspended in protein rich plasma. These different hematologic components perform distinct functions in vivo and thus the ability to efficiently fractionate blood into its individual components has innumerable applications in both clinical diagnosis and biological research. Yet, processing blood is not trivial. In the past decade, a flurry of new microfluidic based technologies has emerged to address this compelling problem. Microfluidics is an attractive solution for this application leveraging its numerous advantages to process clinical blood samples. This paper reviews the various microfluidic approaches realized to successfully fractionate one or more blood components. Techniques to separate plasma from hematologic cellular components as well as isolating blood cells of interest including certain rare cells are discussed. Comparisons based on common separation metrics including efficiency (sensitivity, purity (selectivity, and throughput will be presented. Finally, we will provide insights into the challenges associated with blood-based separation systems towards realizing true point-of-care (POC devices and provide future perspectives.