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Sample records for 5-year longitudinal study

  1. Natural course of behavioral addictions: a 5-year longitudinal study

    Konkolÿ Thege, Barna; Woodin, Erica M; Hodgins, David C.; Williams, Robert J.

    2015-01-01

    Background Resolving the theoretical controversy on the labeling of an increasing number of excessive behaviors as behavioral addictions may also be facilitated by more empirical data on these behavioral problems. For instance, an essential issue to the classification of psychiatric disorders is information on their natural course. However, longitudinal research on the chronic vs. episodic nature of behavioral addictions is scarce. The aim of the present study, therefore, was to provide data ...

  2. A 5-Year Longitudinal Study of Fatigue in Patients With Late-Onset Sequelae of Poliomyelitis

    I.M. Tersteeg; F.S. Koopman; J.M. Stolwijk-Swüste; A. Beelen; F. Nollet

    2011-01-01

    Tersteeg IM, Koopman FS, Stolwijk-Swuste JM, Beelen A, Nollet F, on behalf of the CARPA Study Group. A 5-year longitudinal study of fatigue in patients with late-onset sequelae of poliomyelitis. Arch Phys Med Rehabil 2011; 92:899-904. Objectives: To study the severity and 5-year course of fatigue in

  3. Participation in an Intensive Longitudinal Study with Weekly Web Surveys Over 2.5 Years

    Barber, Jennifer; Kusunoki, Yasamin; Schulz, Paul

    2016-01-01

    Background Technological advances have made it easier for researchers to collect more frequent longitudinal data from survey respondents via personal computers, smartphones, and other mobile devices. Although technology has led to an increase in data-intensive longitudinal studies, little is known about attrition from such studies or the differences between respondents who complete frequently administered surveys in a timely manner, and respondents who do not. Objective We examined respondent characteristics and behaviors associated with continued and on-time participation in a population-based intensive longitudinal study, using weekly web-based survey interviews over an extended period. Methods We analyzed data from the Relationship Dynamics and Social Life study, an intensive longitudinal study that collected weekly web-based survey interviews for 2.5 years from 1003 18- and 19-year-olds to investigate factors shaping the dynamics of their sexual behavior, contraceptive use, and pregnancies. Results Ordinary least squares and logistic regression analyses showed background respondent characteristics measured at baseline were associated with the number of days respondents remained enrolled in the study, the number of interviews they completed, and the odds that they were late completing interviews. In addition, we found that changes in pregnancy-related behaviors reported in the weekly interviews were associated with late completion of interviews. Specifically, after controlling for sociodemographic, personality, contact information, and prior experience variables, we found that weekly reports such as starting to have sex (odds ratio [OR] 1.17, 95% CI 1.03-1.32, P=.01), getting a new partner (OR 1.76, 95% CI 1.53-2.03, P<.001), stopping the use of contraception (OR 1.28, 95% CI 1.10-1.49, P=.001), and having a new pregnancy (OR 5.57, 95% CI 4.26-7.29, P<.001) were significantly associated with late survey completion. However, young women who reported changes in

  4. Predictors and consequences of childhood depressive symptoms: a 5-year longitudinal study.

    Nolen-Hoeksema, S; Girgus, J S; Seligman, M E

    1992-08-01

    A 5-year longitudinal study investigated the interrelationships among children's experiences of depressive symptoms, negative life events, explanatory style, and helplessness behaviors in social and achievement situations. The results revealed that early in childhood, negative events, but not explanatory style, predicted depressive symptoms; later in childhood, a pessimistic explanatory style emerged as a significant predictor of depressive symptoms, alone and in conjunction with negative events. When children suffered periods of depression, their explanatory styles not only deteriorated but remained pessimistic even after their depression subsided, presumably putting them at risk for future episodes of depression. Some children seem repeatedly prone to depressive symptoms over periods of at least 2 years. Depressed children consistently showed helpless behaviors in social and achievement settings. PMID:1500598

  5. A 5-year longitudinal study of fatigue in patients with late-onset sequelae of poliomyelitis.

    Tersteeg, I.M.; Koopman, F.S.; Stolwijk-Swuste, J.M.; Beelen, A.; Nollet, F.

    2011-01-01

    Objectives: To study the severity and 5-year course of fatigue in patients with late-onset sequelae of poliomyelitis (LOSP) and to identify physical and psychosocial determinants of fatigue. Design: Prospective cohort study with 5 measurements over 5 years. Setting: University hospital.Participants:

  6. Evaluation of 5-Year Trends in Knee Society Scores Stratified by Comorbidities: A Prospective, Longitudinal Study.

    Jauregui, Julio J; Issa, Kimona; Cherian, Jeffrey J; Harwin, Steven F; Given, Kristin; Mont, Michael A

    2016-01-01

    Total knee arthroplasties (TKAs) are reliable procedures for treating end-stage knee osteoarthritis with excellent long-term outcomes. The purpose of this study was to longitudinally evaluate temporal trends of Knee Society Scores (KSS) after TKA and to identify potential demographic and comorbid factors that affect these outcomes. This prospective study evaluated 281 patients (108 men and 173 women) with a mean age of 66 years (range, 39-80 years) who underwent primary TKA (minimum follow-up 5 years). During each follow-up visit, KS objective, function, and total scores were evaluated. The effects of different demographics and comorbidities on outcomes were further analyzed using multivariate regression analysis. Following TKA, peak mean KSS were observed at 1-year follow-up (mean, 92 points), after which there was no significant difference in scores at 5 years compared with 1-year follow-up (mean, 92 points). KS function scores were observed to be unchanged from preoperative levels (mean, 53 points) and at 6 weeks (mean, 56 points). These were significantly higher at 3 months (mean, 78 points) and reached a maximum mean peak at 1 year (mean, 85 points). KS objective scores increased earlier than function scores. The demographic variables and comorbidities that demonstrated a significantly negative impact in KS function scores were increased age, female gender, higher body mass index, and several medical comorbidities including immunological and neurological disease, and neoplasm. Race was the only variable that significantly decreased the KS objective scores. KSS after TKA follow temporal trends with scores initially unchanged from preoperative levels for the objective component, but the scores increased for the functional component. All components demonstrated higher levels compared with preoperative scores by 3 months and peaked at 1-year follow-up. At 5-year follow-up, all mean KSS were unchanged relative to peak scores seen at 1 year. Various patient

  7. Surveillance of broad-spectrum antibiotic prescription in Singaporean hospitals: a 5-year longitudinal study.

    Yi-Xin Liew

    Full Text Available BACKGROUND: Inappropriate prescription of antibiotics may contribute towards higher levels antimicrobial resistance. A key intervention for improving appropriate antibiotic prescription is surveillance of prescription. This paper presents the results of a longitudinal surveillance of broad-spectrum antibiotic prescription in 5 public-sector hospitals in Singapore from 2006 to 2010. METHODOLOGY/PRINCIPAL FINDINGS: Quarterly antibiotic prescription data were obtained and converted to defined daily doses (DDDs per 1,000 inpatient-days. The presence of significant trends in antibiotic prescription over time for both individual and combined hospitals was tested by regression analysis and corrected for autocorrelation between time-points. Excluding fluoroquinolones, there was a significant increase in prescription of all monitored antibiotics from an average of 233.12 defined daily doses (DDD/1,000 inpatient-days in 2006 to 254.38 DDD/1,000 inpatient-days in 2010 (Coefficient = 1.13, 95%CI: 0.16-2.09, p = 0.025. Increasing utilization of carbapenems, piperacillin/tazobactam, and Gram-positive agents were seen in the majority of the hospitals, while cephalosporins were less prescribed over time. The combined expenditure for 5 hospitals increased from USD9.9 million in 2006 to USD16.7 million in 2010. CONCLUSIONS/SIGNIFICANCE: The rate of prescription of broad-spectrum antibiotics in Singaporean hospitals is much higher compared to those of European hospitals. This may be due to high rates of antimicrobial resistance. The increase in expenditure on monitored antibiotics over the past 5 years outstripped the actual increase in DDD/1,000 inpatient-days of antibiotics prescribed. Longitudinal surveillance of antibiotic prescription on a hospital and countrywide level is important for detecting trends for formulating interventions or policies. Further research is needed to understand the causes for the various prescription trends and to act on these where

  8. Longitudinal pulmonary functional loss in cotton textile workers: A 5-year follow-up study

    Kahraman, Hasan; Sucakli, Mustafa Haki; Kilic, Talat; Celik, Mustafa; Koksal, Nurhan; Ekerbicer, Hasan Cetin

    2013-01-01

    Background Occupational exposure to cotton dust causes several diseases affecting the lungs, but only limited information is available on effects of long-term exposure. In this study, we aimed to evaluate longitudinal changes in selected parameters of pulmonary function in textile workers. Material/Methods This prospective cohort study began with 196 textile workers in 2006 and was completed in 2011 with 49 workers. We used standardized tests for pulmonary function on participants on the firs...

  9. The developmental relationship between language and motor performance from 3 to 5 years of age: a prospective longitudinal population study

    Wang, Mari Vaage; Lekhal, Ratib; Aarø, Leif Edvard; Holte, Arne; Schjølberg, Synnve

    2014-01-01

    Background: Previous research has found that language and motor skills are closely interrelated developmental areas. This observation has led to questions about the specificity of these domains, and the nature of the associations. In this study, we investigated the longitudinal relationship between language and gross and fine motor performance from 3 to 5 years of age. Methods: We tested the prediction across and within developmental domains using cross-lagged panel models. In ...

  10. Course of intelligence deficits in early onset, first episode schizophrenia: a controlled, 5-year longitudinal study

    Jepsen, Jens Richardt Moellegaard; Fagerlund, Birgitte; Pagsberg, Anne Katrine;

    2010-01-01

    predominantly been characterized as relatively stable in these studies. However, comparisons of IQs from different test versions based on the different norms may not permit unequivocal interpretations. The objective of the current study was to compare the development of intelligence in EOS patients (N = 10......, and the same norms were used to derive IQs at baseline and follow-up. Significantly smaller change in mean full scale intelligence quotient (FSIQ) was found in diagnostically stable EOS patients compared with healthy controls during the follow-up period. However, no statistically significant...

  11. Associations between Teacher Emotional Support and Depressive Symptoms in Australian Adolescents: A 5-Year Longitudinal Study

    Pössel, Patrick; Rudasill, Kathleen Moritz; Sawyer, Michael G.; Spence, Susan H.; Bjerg, Annie C.

    2013-01-01

    Approximately 1/5 of adolescents develop depressive symptoms. Given that youths spend a good deal of their lives at school, it seems plausible that supportive relationships with teachers could benefit their emotional well-being. Thus, the purpose of this study is to examine the association between emotionally supportive teacher relationships and…

  12. Prospective longitudinal cohort study on cumulative 5-year delivery and adoption rates among 1338 couples initiating infertility treatment

    Pinborg, A; Hougaard, C O; Andersen, Anders Nyboe;

    2009-01-01

    BACKGROUND The objective was to assess crude 5-year delivery rates after assisted reproductive technology (ART) treatment, intrauterine inseminations (IUI), spontaneous conceptions (SC) and adoptions in a large infertile cohort. METHODS A prospective longitudinal survey comprised 1338 infertile...... couples starting public infertility programmes offering IUIs and three free ART cycles during 2000-2001. The cohort was cross-linked with the National Medical Birth Register to obtain delivery rates for all 1338 couples. More detailed data were available from 817 women responding to a 5-year follow...

  13. The role of cell transplantation in modifying the course of limb girdle muscular dystrophy: a longitudinal 5-year study

    Sharma A

    2015-09-01

    Full Text Available Alok Sharma,1 Hemangi Sane,2 Nandini Gokulchandran,1 Sushant Gandhi,3 Pradnya Bhovad,3 Dipti Khopkar,2 Amruta Paranjape,2 Khushboo Bhagwanani,3 Prerna Badhe1 1Department of Medical Services and Clinical Research, 2Department of Research and Development, 3Department of Neurorehabilitation, NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Centre, Nerul, Navi Mumbai, Maharashtra, India Abstract: Limb girdle muscular dystrophy (LGMD, a group of progressive degenerative disorders, causes functional limitation affecting the quality of life. Cell therapy is being widely explored and preliminary studies have shown beneficial effects. Cell therapy induces trophic-factors release, angiogenesis, anti-inflammation, and protein synthesis, which helps in the reparative process at the microcellular level. In this 5-year longitudinal study, the effect of autologous bone marrow mononuclear cells is studied on the natural course of 65 patients with LGMD. Functional Independence Measure and manual muscle testing showed statistically significant improvement, post-cell transplantation. The key finding of this study was demonstration of a plateau phase in the disease progression of the patients. No adverse events were noted. Autologous bone marrow mononuclear cells may be a novel, safe, and effective treatment approach to control the rate of progression of LGMD, thus improving the functional outcomes. Further randomized controlled trials are required. Keywords: cell therapy, autologous, bone marrow

  14. Asperger Syndrome and Autism: A Comparative Longitudinal Follow-Up Study More than 5 Years after Original Diagnosis

    Cederlund, Mats; Hagberg, Bibbi; Billstedt, Eva; Gillberg, I. Carina; Gillberg, Christopher

    2008-01-01

    Prospective follow-up study of 70 males with Asperger syndrome (AS), and 70 males with autism more than 5 years after original diagnosis. Instruments used at follow-up included overall clinical assessment, the Diagnostic Interview for Social and Communication Disorders, Wechsler Intelligence Scales, Vineland Adaptive Behavior Scales, and Global…

  15. Second Language Acquisition at the Early Childhood Level: A 5-Year Longitudinal Case Study of Pre-Kindergarten through First-Grade Students

    Billak, Bonnie

    2013-01-01

    This 5-year longitudinal study investigated the English language acquisition and development of students in pre-Kindergarten through Grade 1 at a U.S.-accredited international school. Of the 1,509 students tested, the overwhelming majority were nonnative English speakers. The data provide valuable insight into the rate of second language…

  16. The Course of Pain Intensity in Patients Undergoing Herniated Disc Surgery: A 5-Year Longitudinal Observational Study

    Dorow, Marie; Löbner, Margrit; Stein, Janine; Pabst, Alexander; Konnopka, Alexander; Meisel, Hans J.; Günther, Lutz; Meixensberger, Jürgen; Stengler, Katarina; König, Hans-Helmut; Riedel-Heller, Steffi G.

    2016-01-01

    Objectives The aims of this study are to answer the following questions (1) How does the pain intensity of lumbar and cervical disc surgery patients change within a postoperative time frame of 5 years? (2) Which sociodemographic, medical, work-related, and psychological factors are associated with postoperative pain in lumbar and cervical disc surgery patients? Methods The baseline survey (T0; n = 534) was conducted 3.6 days (SD 2.48) post-surgery in the form of face-to-face interviews. The follow-up interviews were conducted 3 months (T1; n = 486 patients), 9 months (T2; n = 457), 15 months (T3; n = 438), and 5 years (T4; n = 404) post-surgery. Pain intensity was measured on a numeric rating-scale (NRS 0–100). Estimated changes to and influences on postoperative pain by random effects were accounted by regression models. Results Average pain decreased continuously over time in patients with lumbar herniated disc (Wald Chi² = 25.97, pdepression (pdepressive symptoms were associated with postoperative pain. The findings may promote multimodal rehabilitation concepts including psychological and work-related support. PMID:27243810

  17. Multiple births and maternal mental health from pregnancy to 5 years after birth: A longitudinal population-based cohort study

    Eivind Ystrom

    2014-12-01

    Full Text Available Background: There is a lack of population-based studies on multiple births and maternal mental health. Having a high-risk pregnancy by bearing two or more children is a stressful life event, and the challenges of parenting two or more children probably also lead to a high level of parental stress. There are a few results on multiple births and maternal mental health from studies on in vitro fertilization samples. The only previous cohort study on multiple birth and maternal mental health included a single measure of depressive symptoms at 9 months postpartum. We aim to estimate the relative risk for depression and anxiety after multiple birth in a population-based prospective cohort study while adjusting for factors prior and subsequent to fertilization.Methods: We used data from 87,807 pregnancies included in the Norwegian Mother and Child Cohort study. Information on multiple birth was retrieved from the Norwegian Medical Birth Registry, and maternal mental health was assessed at 17th and 30th week of gestation and 0.5, 1.5, 3, and 5 years postpartum. There were 1,842 plural births included in the study (i.e. 1,821 twin births and 21 higher order births. We predicted maternal mental health at each time point, subsequently adjusting for 1 factors prior to fertilization (e.g. maternal age and in vitro fertilization; 2 factors during pregnancy (e.g. hypertensive states; 3 factors at delivery (e.g. cesarean section; 4 child-related postnatal complications (e.g. intracranial hemorrhage; and 5 concurrent depression or anxiety after pregnancy.Results: Adjusted for antecedents of plural birth, mothers expecting a plural birth had a normal risk for anxiety (RR=1.05; 95% CI 0.92-1.20 and depression (RR=1.02; 95% CI 0.89-1.16 at 17th week of gestation. However, plural birth was associated with maternal depression at 1.5, 3, and 5 years postpartum and maternal anxiety at 3 years postpartum. The trend was for the association to increase across time, and

  18. The Course of Pain Intensity in Patients Undergoing Herniated Disc Surgery: A 5-Year Longitudinal Observational Study.

    Marie Dorow

    Full Text Available The aims of this study are to answer the following questions (1 How does the pain intensity of lumbar and cervical disc surgery patients change within a postoperative time frame of 5 years? (2 Which sociodemographic, medical, work-related, and psychological factors are associated with postoperative pain in lumbar and cervical disc surgery patients?The baseline survey (T0; n = 534 was conducted 3.6 days (SD 2.48 post-surgery in the form of face-to-face interviews. The follow-up interviews were conducted 3 months (T1; n = 486 patients, 9 months (T2; n = 457, 15 months (T3; n = 438, and 5 years (T4; n = 404 post-surgery. Pain intensity was measured on a numeric rating-scale (NRS 0-100. Estimated changes to and influences on postoperative pain by random effects were accounted by regression models.Average pain decreased continuously over time in patients with lumbar herniated disc (Wald Chi² = 25.97, p<0.001. In patients with cervical herniated disc a reduction of pain was observed, albeit not significant (Chi² = 7.02, p = 0.135. Two predictors were associated with postoperative pain in lumbar and cervical disc surgery patients: the subjective prognosis of gainful employment (p<0.001 and depression (p<0.001.In the majority of disc surgery patients, a long-term reduction of pain was observed. Cervical surgery patients seemed to benefit less from surgery than the lumbar surgery patients. A negative subjective prognosis of gainful employment and stronger depressive symptoms were associated with postoperative pain. The findings may promote multimodal rehabilitation concepts including psychological and work-related support.

  19. Growth in Reading Skills of Children from Diverse Linguistic Backgrounds: Findings from a 5-Year Longitudinal Study

    Lesaux, Nonie K.; Rupp, Andre A.; Siegel, Linda S.

    2007-01-01

    This article reports on the results of a longitudinal investigation of the reading development of a sample of 824 children (406 girls, 418 boys). The sample included 689 native English-speaking (L1) children and 135 English-language learners (ELLs) representing 33 different native languages. In kindergarten and 4th grade, children's word reading,…

  20. Multiple births and maternal mental health from pregnancy to 5 years after birth: a longitudinal population-based cohort study

    Eivind Ystrom; Ted Reichborn-Kjennerud; Kristian Tambs; Per Magnus; Anne Mari Torgersen; Kristin Gustavson

    2014-01-01

    Background: There is a lack of population-based studies on multiple births and maternal mental health. Having a high-risk pregnancy by bearing two or more children is a stressful life event, and the challenges of parenting two or more children probably also lead to a high level of parental stress. There are a few results on multiple births and maternal mental health from studies on in vitro fertilization samples. The only previous cohort study on multiple birth and maternal mental health incl...

  1. Ability Emotional Intelligence, Trait Emotional Intelligence, and Academic Success in British Secondary Schools: A 5 Year Longitudinal Study

    Qualter, Pamela; Gardner, Kathryn J.; Pope, Debbie J.; Hutchinson, Jane M.; Whiteley, Helen E.

    2012-01-01

    This study examines the long-term effects of ability- and trait EI on academic performance for British adolescents. The sample comprised 413 students from three secondary schools in the North-West of England. Students completed tests of ability EI, trait EI, personality, and cognitive ability in Year 7 (mean age = 11 years 2 months). Performance…

  2. Long-Term Effects of the Life Skills Program IPSY on Substance Use: Results of a 4.5-Year Longitudinal Study.

    Weichold, Karina; Blumenthal, Anja

    2016-01-01

    This study investigated the long-term effectiveness of a Life Skills program with regard to use and proneness to legal and illicit drug use across a 4.5-year study interval. The universal school-based Life Skills program IPSY (Information + Psychosocial Competence = Protection) against adolescent substance use was implemented over 3 years (basic program in grade 5 and booster sessions in grades 6 and 7). Over the same time period, it was evaluated based on a longitudinal quasi-experimental design with intervention and control group, including two follow-up assessments after program completion [six measurement points; N (T1) = 1657 German students; M age (T1) = 10.5 years]. Applying an HLM approach, results showed that participation in IPSY had a significant effect on the frequency of smoking, and proneness to illicit drug use, across the entire study period. In addition, shorter-term effects were found for the frequency of alcohol use in that intervention effects were evident until the end of program implementation but diminished 2 years later. Thus, IPSY can be deemed an effective intervention against tobacco use and proneness to and use of illicit drugs during adolescence; however, further booster sessions may be necessary in later adolescence to enhance youths' resistance skills when alcohol use becomes highly normative among peers. PMID:26202801

  3. Transverse development of the human jaws between the ages of 8.5 and 15.5 years, studied longitudinally with use of implants.

    Korn, E L; Baumrind, S

    1990-06-01

    We report longitudinal data on the transverse widening of the maxilla and mandible from a sample of normal subjects (11 males and 20 females) with metallic implants of the Bjork type. Data were from measurements on lateral and frontal (posterior-anterior) cephalograms generated at annual intervals between the ages of 8.5 and 15.5 years (although data were not available for all subjects at all time points). The maxillary data were, in general, similar to those reported by Bjork and Skieller (1974, 1977) for a smaller sample of slightly younger boys. During the age interval studied, transverse widening was greater in the more posterior part of the palate. [The mean annual rate of change in the posterior-most (zygomatic) region was 0.43 mm, sd = 0.18 mm; p less than 0.001.] Although the rate of palatal widening was not large in absolute terms, widening appeared to continue throughout the age interval under study, and there was no evidence to support the conventionally accepted idea that palatal growth in the transverse dimension tapers off substantially or even ceases during the age interval under observation. Evidence of statistically significant widening of the mandibular arch by means of transverse rotation of the osseous matrix was noted in nine of the 29 subjects for whom three-dimensional mandibular information was available. For these nine subjects, the estimated annual increase in mandibular arch angle ranged from 0.52 degrees to 1.40 degrees. As far as we are aware, this is the first report of mandibular matrix rotation in the transverse direction from a sample of subjects with metallic implants. The finding that spontaneous changes in this dimension are relatively common raises the possibility that classical attitudes concerning the immutability of osseous relationships in the symphyseal region during growth may be inappropriate. PMID:2355125

  4. Information Systems in Teacher Preparation Programs: What Can We Learn from a 5-Year Longitudinal Case Study of an Electronic Portfolio Database?

    Swan, Gerry

    2009-01-01

    In 2003, a portfolio system was implemented to manage the data associated with the field experiences in a teacher education program at a research institution in the southeast region of the United States. In this longitudinal study, the implementation trends from usage data extracted from the system are used to discuss the implications for the use…

  5. Dietary diversity, animal source food consumption and linear growth among children aged 1-5 years in Bandung, Indonesia: a longitudinal observational study.

    Muslimatun, Siti; Wiradnyani, Luh Ade Ari

    2016-07-01

    Dietary diversity involves adequate intake of macronutrient and micronutrient. The inclusion of animal source foods (ASF) in the diet helps prevent multiple nutrient deficiencies and any resultant, linear growth retardation. The objective of the current study was to assess the relationship between dietary diversity, ASF consumption and height-for-age z-score (HAZ) among children aged 12-59 months old across a 1-year observation. This longitudinal observational study without controls was conducted among four age groups: 12-23 months (n 57), 24-35 months (n 56), 36-47 months (n 58) and 48-59 months (n 56). Anthropometry and dietary intake were measured during each of four visits at 16-20-week intervals. The general characteristics and other observations were only collected at baseline and endline. During the year-long study period, approximately 27 % of the children ate a diverse diet (consumed ≥6 out of 9 food groups) according to ≥3 visits. ASF consumption was high, particularly for eggs, poultry, processed meats and liquid milk. Yet, micronutrient intake inadequacy, especially of Zn, Ca, Fe and vitamin A, was highly prevalent. A multivariate regression analysis showed that the consumption of a diverse diet and ASF was not significantly associated with the HAZ at endline, after controlling for demographic characteristics and the baseline HAZ. The consumption of a diverse diet was significantly associated with Ca intake adequacy. Moreover, ASF consumption was significantly associated with adequate intake of protein and micronutrients, particularly vitamin A, Ca and Zn. Thus, the recommendation is to continue and strengthen the promotion of consuming a diverse diet that includes ASF in supporting the linear growth of young children. PMID:26817493

  6. A 5-year longitudinal study of schistosomiasis transmission in Shian village, the Anning River Valley, Sichuan Province, the Peoples' Republic of China

    Li Yue-Sheng

    2011-03-01

    Full Text Available Abstract Background Schistosoma japonicum is a major public health concern in the Peoples' Republic of China (PRC, with over one million people infected and another 50 million living in areas at risk of infection. Based on ecological, environmental, population genetic and molecular factors, schistosomiasis transmission in PRC can be categorised into four discrete ecosystems or transmission modes. It is predicted that the Three Gorges Dam (TGD will impact upon the transmission of schistosomiasis in the PRC, with varying degree across the four transmission modes. We undertook longitudinal surveillance from 2002 to 2006 in sentinel villages both above and below the TGD across five provinces (Hunan, Jiangxi, Hubei, Anhui and Sichuan to determine whether there was any impact of the TGD on schistosomiasis transmission during its construction. Here we present the results from a schistosomiasis-endemic village located above the dam in Sichuan Province. Results Baseline results showed a human S. japonicum prevalence of 42.0% (95% CI: 36.6-47.5. At follow-up, results showed that the incidence of S. japonicum infection in the selected human cohort in Shian decreased by three quarters from 46% in 2003 to 11.3% in 2006. A significant (P S. japonicum infection in bovines declined from 11.8% in the first year to zero in the final year of follow-up. Conclusions The substantial decrease in human (75% and bovine (100% incidence observed in Shian village can probably be attributed to the annual human and bovine PZQ treatment of positives; as seen in drug (PZQ intervention studies in other parts of PRC. If an increase in schistosome transmission had occurred as a result of the TGD, it would be of negligible size compared to the treatment induced decline seen here. It appears therefore that the construction of the TGD had virtually no impact on schistosomiasis transmission in Shian village over the period of study. Furthermore, contrary to previous reports from

  7. Erythema Nodosum Epidemiology: 5-Years Retrospective Study

    Arife Öz

    2012-09-01

    Full Text Available Objective: Erythema nodosum (EN is the most common type of septal panniculitis. Although triggering factors of EN are drugs, infections, malignancies, inflammatory diseases however disease is idiopathic in 32-72%. Factors are changing from region to region and from country to country. In this study, our aim was to investigate the etiologic factors and to evaluate the clinic and laboratory findings of EN. Methods: Sixty-six patients who were histopathologically diagnosed as EN in our department between 2005 and 2010 were included to this study. Demographic data and treatment were evaluated. Results: Fifty-two of 66 patients had underlying etiologic factors (Group 1 and 14 of were idiopatic (Group 2. Most common etiologic factor was Behçet’s disease (n=15, and followed by drug (n=13, sarcoidosis (n=10, upper respiratory tract infection (n=6, autoimmune disease (n=4, pregnancy (n=2, tuberculosis (n=2 in decreasing frequencies. In our study malignancy and inflammatory bowel disease are not appointed. Conclusion: Behcet’s disease is a rare cause of EN. In other studies in our country the idiopatic group was in majority. In our study because of finding the common etiologic factor as Behçet’s disease due to being of Behçet’s disease high prevalance (11-42/10000 in our country and existence of Behçet’s disease center in our faculty (Turk J Dermatol 2012; 6: 87-90

  8. Erythema Nodosum Epidemiology: 5-Years Retrospective Study

    Arife Öz; Kenan Aydoğan; Şaduman Balaban Adım; Belçin İzol; Hayriye Sarıcaoğlu; Emel Bülbül Başkan; Şükran Tunalı

    2012-01-01

    Objective: Erythema nodosum (EN) is the most common type of septal panniculitis. Although triggering factors of EN are drugs, infections, malignancies, inflammatory diseases however disease is idiopathic in 32-72%. Factors are changing from region to region and from country to country. In this study, our aim was to investigate the etiologic factors and to evaluate the clinic and laboratory findings of EN. Methods: Sixty-six patients who were histopathologically diagnosed as EN in our depar...

  9. The Feeding Practices and Structure Questionnaire (FPSQ-28): A parsimonious version validated for longitudinal use from 2 to 5 years.

    Jansen, Elena; Williams, Kate E; Mallan, Kimberley M; Nicholson, Jan M; Daniels, Lynne A

    2016-05-01

    Prospective studies and intervention evaluations that examine change over time assume that measurement tools measure the same construct at each occasion. In the area of parent-child feeding practices, longitudinal measurement properties of the questionnaires used are rarely verified. To ascertain that measured change in feeding practices reflects true change rather than change in the assessment, structure, or conceptualisation of the constructs over time, this study examined longitudinal measurement invariance of the Feeding Practices and Structure Questionnaire (FPSQ) subscales (9 constructs; 40 items) across 3 time points. Mothers participating in the NOURISH trial reported their feeding practices when children were aged 2, 3.7, and 5 years (N = 404). Confirmatory Factor Analysis (CFA) within a structural equation modelling framework was used. Comparisons of initial cross-sectional models followed by longitudinal modelling of subscales, resulted in the removal of 12 items, including two redundant or poorly performing subscales. The resulting 28-item FPSQ-28 comprised 7 multi-item subscales: Reward for Behaviour, Reward for Eating, Persuasive Feeding, Overt Restriction, Covert Restriction, Structured Meal Setting and Structured Meal Timing. All subscales showed good fit over 3 time points and each displayed at least partial scalar (thresholds equal) longitudinal measurement invariance. We recommend the use of a separate single item indicator to assess the family meal setting. This is the first study to examine longitudinal measurement invariance in a feeding practices questionnaire. Invariance was established, indicating that the subscales of the shortened FPSQ-28 can be used with mothers to validly assess change in 7 feeding constructs in samples of children aged 2-5 years of age. PMID:26911263

  10. Sexual function in multiple sclerosis. A 5-year follow-up study

    Stenager, E; Stenager, E N; Jensen, K

    1996-01-01

    Sexual dysfunction is known to occur in multiple sclerosis (MS). The purpose of the study is to describe the change in sexual function and symptoms in a longitudinal study. Forty-nine patients (27 females, 22 males) with definite MS were interviewed and examined with 5 years interval. The number of...

  11. A 5-year retrospective clinical study of the Dentium implants

    Lee, Jeong-Yol; Park, Hyo-Jin; Kim, Jong-Eun; Choi, Yong-Geun; Kim, Young-Soo; Huh, Jung-Bo; Shin, Sang-Wan

    2011-01-01

    PURPOSE The aim of this retrospective study was to evaluate cumulative survival rate (CSR) of Implantium implants followed for 5 years and association between risk factors and the CSR. MATERIALS AND METHODS A total of two hundred forty-nine Implantium Implants System (Dentium, Seoul, Korea) placed in ninety-five patients from 2004 to 2009 were investigated with several identified risk factors (sex, systemic disease, smoking, alchohol, reason of tooth loss, length, arch (maxilla or mandible), ...

  12. Reconsidering the Effects of Poverty and Social Support on Health: A 5-Year Longitudinal Test of the Stress-Buffering Hypothesis

    Moskowitz, David; Vittinghoff, Eric; Schmidt, Laura

    2012-01-01

    Prior research in the general population has found that social support can buffer the adverse effects of stressors on health. However, both stressors and social support may be qualitatively different for those living in urban poverty. We examined the effects of social support and poverty-specific stressors on self-rated health. We used data from the Welfare Client Longitudinal Survey (WCLS), a 5-year longitudinal study of 718 public aid recipients. We measured received social support and “net...

  13. Cytokines and bone loss in a 5-year longitudinal study--hormone replacement therapy suppresses serum soluble interleukin-6 receptor and increases interleukin-1-receptor antagonist: the Danish Osteoporosis Prevention Study

    Abrahamsen, Bo; Bonnevie-Nielsen, V; Ebbesen, E N; Gram, J; Beck-Nielsen, H

    2000-01-01

    The proinflammatory cytokines interleukin-1 beta (IL-1 beta) and IL-6 may play a central role in the acceleration of postmenopausal bone loss, but observational studies have led to contradictory results. Estrogen-dependent changes in the production of IL-1 receptor antagonist (IL-1ra) and the.......16; p = 0.17). In conclusion, serum IL-1ra and sIL-6R are influenced by HRT and are associated with the rate of bone loss in perimenopausal women....

  14. Planned and unplanned complex suicides: a 5-year retrospective study.

    Racette, Stéphanie; Sauvageau, Anny

    2007-03-01

    The notion of planned and unplanned complex suicides first appeared in 1974 by Marcinkowski and, since then, no systematic study of complex suicides has been published in the English forensic literature. Here, the authors present a 5-year retrospective study of complex suicides. Nineteen complex suicides were reviewed: five unplanned and 14 planned, including the first case of an unplanned complex suicide in a woman. All cases were analyzed in terms of gender, age, methods of suicide, the presence of a suicide note, and past suicide attempts, and statistically compared with a 50-case sample of simple suicides. A further comparison was established with compiled data from the literature. Similarities were revealed regarding incidence of complex suicides, male gender predominance, and types of methods used. In contrast, results showed a higher average age for planned complex suicide victims. Finally, the authors discuss the application of the complex suicide definition. PMID:17316249

  15. Multiple Determinants of Externalizing Behavior in 5-Year-Olds: A Longitudinal Model

    Smeekens, Sanny; Riksen-Walraven, J. Marianne; van Bakel, Hedwig J. A.

    2007-01-01

    In a community sample of 116 children, assessments of parent-child interaction, parent-child attachment, and various parental, child, and contextual characteristics at 15 and 28 months and at age 5 were used to predict externalizing behavior at age 5, as rated by parents and teachers. Hierarchical multiple regression analysis and path analysis yielded a significant longitudinal model for the prediction of age 5 externalizing behavior, with independent contributions from the following predicto...

  16. A Study on Mental Disorders: 5-year Retrospective Study

    Celine, Thalappillil Mathew; Antony, Jimmy

    2014-01-01

    Background: “Mental disorder” is the most common used term in the modern life and the main reason behind this may be the mechanical way of life or stress and strain among youth. Aim: To find the pattern of mental disorders of hospitalized patients in a medical college hospital from 1st April 2005 to 31st March 2010. Settings and Design: A retrospective study conducted among the patients admitted with mental disorders in a medical college hospital from 1st April 2005 to 31st March 2010. Materi...

  17. Clustering of energy balance-related behaviors in 5-year-old children: Lifestyle patterns and their longitudinal association with weight status development in early childhood

    Gubbels Jessica S; Kremers Stef PJ; Stafleu Annette; Goldbohm R; de Vries Nanne K; Thijs Carel

    2012-01-01

    Abstract Background This study identified lifestyle patterns by examining the clustering of eating routines (e.g. eating together as a family, having the television on during meals, duration of meals) and various activity-related behaviors (i.e. physical activity (PA) and sedentary screen-based behavior) in 5-year-old children, as well as the longitudinal association of these patterns with weight status (BMI and overweight) development up to age 8. Methods Data originated from the KOALA Birth...

  18. Clustering of energy balance-related behavioural in 5-year-old children: lifestyle patterns and their longitudinal association with weight status development in early childhood

    J. S. Gubbels; Kremers, S.P.; Stafleu, A.; Goldbohm, R.A.; de Vries, N. K.; Thijs, C.

    2012-01-01

    Background: This study identified lifestyle patterns by examining the clustering of eating routines (e.g. eating together as a family, having the television on during meals, duration of meals) and various activity-related behaviors (i.e. physical activity (PA) and sedentary screen-based behavior) in 5-year-old children, as well as the longitudinal association of these patterns with weight status (BMI and overweight) development up to age 8. Methods: Data originated from the KOALA Birth Cohort...

  19. Neurodevelopmental Outcomes at 5 Years in Children Exposed Prenatally to Maternal Dental Amalgam: The Seychelles Child Development Nutrition Study

    Watson, Gene E.; van Wijngaarden, Edwin; Love, Tanzy M. T.; McSorley, Emeir M; Bonham, Maxine P; Mulhern, Maria S.; Yeates, Alison J; Davidson, Philip W; Shamlaye, Conrad F.; Strain, J.J.; Thurston, Sally W.; Harrington, Donald; Zareba, Grazyna; Wallace, Julie M. W.; Myers, Gary J.

    2013-01-01

    Limited human data are available to assess the association between prenatal mercury vapor (Hg0) exposure from maternal dental amalgam restorations and neurodevelopment of children. We evaluated the association between maternal dental amalgam status during gestation and children’s neurodevelopmental outcomes at 5 years in the Seychelles Child Development Nutrition Study (SCDNS). Maternal amalgam status was determined prospectively in a longitudinal cohort study examining the associations of pr...

  20. Prognosis for Emergency Physician with Substance Abuse Recovery: 5-year Outcome Study

    John S. Rose

    2014-02-01

    Full Text Available Introduction: Emergency physicians (EPs are reported to have a higher rate of substance use disorder (SUD than most specialties, although little is known about their prognosis. We examined the outcomes of emergency physician compared to other physicians in the treatment of substance use disorders in Physician Health Programs (PHP. Methods: This study used the dataset from a 5-year, longitudinal, cohort study involving 904 physicians with diagnoses of SUD consecutively admitted to one of 16 state PHPs between 1995 and 2001. We compared 56 EPs to 724 other physicians. Main outcome variables were rates of relapse, successful completion of monitoring, and return to clinical practice. Results: EPs had a higher than expected rate of SUD (odds ratio [OR] 2.7 confidence interval [CI]: 2.1–3.5, p,0.001. Half of each group (49% of EPs and 50% of the others enrolled in a PHP due to alcohol-related problems. Over a third of each group (38% of EPs and 34% of the others enrolled due to opioid use. During monitoring by the PHPs, 13% of EPs had at least one positive drug test compared to 22% of the other physicians; however, this difference was not significant (p¼0.13. At the end of the 5-year follow-up period, 71% of EPs and 64% of other physicians had completed their contracts and were no longer required to be monitored (OR 1.4 [CI: 0.8-2.6], p ¼ 0.31. The study found that the proportion of EPs (84% continuing their medical practice was generally as high as that of other physicians (72% (OR 2.0 [CI: 1.0–4.1], p ¼ 0.06. Conclusion: In the study EPs did very well in the PHPs with an 84% success rate in completion and return to clinical practice at 5 years. Of the 3 outcome variables measured, rates of relapse, successful completion of monitoring, and return to clinical practice, EPs had a high rate of success on all variables compared to the other physician cohort. These data support the conclusion that EM physicians do well following treatment of SUD

  1. Pathways of Pb and Mn observed in a 5-year longitudinal investigation in young children and environmental measures from an urban setting

    We monitored 108 children ≤5 years on a 6-month basis for up to 5 years in a major urban setting. Samples (n ∼ 7000) included blood, urine, handwipes (interior, and after exterior playing), 6-day duplicate diet, drinking water, interior house and day care dust-fall accumulation using petri dishes, exterior dust-fall accumulation, exterior dust sweepings, paint, soil and urban air. The geometric mean blood Pb (PbB) was 2.1 μg/dL and blood Mn (MnB) was 10.0 μg/L. Following a path modelling approach, mixed model analyses for a fully adjusted model showed the strongest associations for PbB were with interior house dust and soil; for MnB there were no significant associations with any predictors. Predictor variables only explained 9% of the variance for Pb and 0.7% for Mn. Relationships between environmental measures and PbB in children are not straightforward; soil and dust sweepings contribute only about 1/5th of the amounts to PbB found in other studies. - Highlights: • 5-year longitudinal study of young children in urban setting. • Samples analysed for Pb and Mn in blood and environmental samples. • Modified structural equation modelling. • Strongest associations for blood Pb with house dust and soil. • Soil and dust contribute very small amounts to blood Pb. - This study provides useful insights about the environmental pathways leading to Pb and Mn exposure in young children

  2. Insight, psychopathology, explanatory models and outcome of schizophrenia in India: a prospective 5-year cohort study

    Johnson Shanthi

    2012-09-01

    Full Text Available Abstract Background The sole focus of models of insight on bio-medical perspectives to the complete exclusion of local, non-medical and cultural constructs mandates review. This study attempted to investigate the impact of insight, psychopathology, explanatory models of illness on outcome of first episode schizophrenia. Method Patients diagnosed to have DSM IV schizophrenia (n = 131 were assessed prospectively for insight, psychopathology, explanatory models of illness at baseline, 6, 12 and 60 months using standard instruments. Multiple linear and logistic regression and generalized estimating equations (GEE were employed to assess predictors of outcome. Results We could follow up 95 (72.5% patients. Sixty-five of these patients (68.4% achieved remission. There was a negative relationship between psychosis rating and insight scores. Urban residence, fluctuating course of the initial illness, and improvement in global functioning at 6 months and lower psychosis rating at 12 months were significantly related to remission at 5 years. Insight scores, number of non-medical explanatory models and individual explanatory models held during the later course of the illness were significantly associated with outcome. Analysis of longitudinal data using GEE showed that women, rural residence, insight scores and number of non-medical explanatory models of illness held were significantly associated with BPRS scores during the study period. Conclusions Insight, the disease model and the number of non-medical model positively correlated with improvement in psychosis arguing for a complex interaction between the culture, context and illness variables. These finding argue that insight and explanatory models are secondary to psychopathology, course and outcome of the illness. The awareness of mental illness is a narrative act in which people make personal sense of the many challenges they face. The course and outcome of the illness, cultural context

  3. Clustering of energy balance-related behaviors in 5-year-old children: Lifestyle patterns and their longitudinal association with weight status development in early childhood

    Gubbels Jessica S

    2012-06-01

    Full Text Available Abstract Background This study identified lifestyle patterns by examining the clustering of eating routines (e.g. eating together as a family, having the television on during meals, duration of meals and various activity-related behaviors (i.e. physical activity (PA and sedentary screen-based behavior in 5-year-old children, as well as the longitudinal association of these patterns with weight status (BMI and overweight development up to age 8. Methods Data originated from the KOALA Birth Cohort Study (N = 2074 at age 5. Principal component analysis (PCA was used to identify lifestyle patterns. Backward regression analyses were used to examine the association of lifestyle patterns with parent and child background characteristics, as well as the longitudinal associations between the patterns and weight status development. Results Four lifestyle patterns emerged from the PCA: a ‘Television–Snacking’ pattern, a ‘Sports–Computer’ pattern, a ‘Traditional Family’ pattern, and a “Fast’ Food’ pattern. Child gender and parental educational level, working hours and body mass index were significantly associated with the scores for the patterns. The Television–Snacking pattern was positively associated with BMI (standardized regression coefficient β = 0.05; p p = 0.06. In addition, the Sports–Computer pattern was significantly positively associated with an increased risk of becoming overweight at age 7 (OR = 1.28, p  Conclusions The current study showed the added value of including eating routines in cross-behavioral clustering analyses. The findings indicate that future interventions to prevent childhood overweight should address eating routines and activity/inactivity simultaneously, using the synergy between clustered behaviors (e.g. between television viewing and snacking.

  4. A 5 year prospective study of patient-relevant outcomes after total knee replacement

    Nilsdotter, A-K; Toksvig-Larsen, S; Roos, E M

    2008-01-01

    men, mean age 71 (51-86) assigned for TKR at the Department of Orthopaedics at Lund University Hospital were included in the study. The self-administered questionnaires Knee injury and Osteoarthritis Outcome Score (KOOS) and SF-36 were mailed preoperatively and 6 months, 12 months and at 5 years......OBJECTIVE: To prospectively describe self-reported outcomes up to 5 years after total knee replacement (TKR) in Osteoarthritis (OA) and to study which patient-relevant factors may predict outcomes for pain and physical function (PF). METHODS: 102 consecutive patients with knee OA, 63 women and 39...

  5. Population-based 5-year follow-up study in Taiwan of dementia and risk of stroke.

    Mu-En Liu

    Full Text Available BACKGROUND: This study estimates the risk of stroke within 5 years of newly diagnosed dementia among elderly persons aged 65 and above. We examined the relationship between antipsychotic usage and development of stroke in patients with dementia. METHODS: We conducted a nationwide 5-year population-based study using data retrieved from the Longitudinal Health Insurance Database 2005 (LHID2005 in Taiwan. The study cohort comprised 2243 patients with dementia aged ≥65 years who had at least one inpatient service claim or at least 2 ambulatory care claims, whereas the comparison cohort consisted of 6714 randomly selected subjects (3 for every dementia patient and were matched with the study group according to sex, age, and index year. We further classified dementia patients into 2 groups based on their history of antipsychotic usage. A total of 1450 patients were classified into the antipsychotic usage group and the remaining 793 patients were classified into the non-antipsychotic usage group. Cox proportional-hazards regressions were performed to compute the 5-year stroke-free survival rates after adjusting for potentially confounding factors. RESULTS: The dementia patients have a 2-fold greater risk of developing stroke within 5 years of diagnosis compared to non-dementia age- and sex-matched subjects, after adjusting for other risk factors (95% confidence interval (CI = 2.58-3.08; P<.001. Antipsychotic usage among patients with dementia increases risk of stroke 1.17-fold compared to patients without antipsychotic treatment (95% CI = 1.01-1.40; P<.05. CONCLUSIONS: Dementia may be an independent risk factor for stroke, and the use of antipsychotics may further increase the risk of stroke in dementia patients.

  6. Masticatory function and patient satisfaction with implant-supported mandibular overdentures: a prospective 5-year study

    Bakke, Merete; Holm, Betty; Gotfredsen, Klaus

    2002-01-01

    PURPOSE: The aim of this study was to assess the outcome of treatment with implant-supported mandibular overdentures in terms of biting and chewing, in entirely satisfied and not fully satisfied patients. MATERIALS AND METHODS: Twelve edentulous patients who had worn dentures for at least 5 years...

  7. Clinical Evaluation of Small Diameter Straumann Implants in Partially Edentulous Patients: A 5-Year Retrospective Study

    S. OZER

    2011-06-01

    Full Text Available Objective: The aim of the present study was to retrospectively evaluate small-diameter (3.3 mm Straumann® dental implants placed in the maxilla or the mandible over a period of 5 years in function.Materials and Methods: Twenty- eight partially edentulous patients received a total of 48 implants over a 5-year period. After the standard healing period (3 to 6 months, the implants were restored with single-tooth prostheses or fixed partial dentures. All patients were followed according to a strict maintenance program with regular recalls. The cumulative survival rates of implants were analyzed and prosthetic complications were assessed.Results: After 5 years of function, one single 10-mm-long implant in the maxillary premolar region was lost because of recurrent peri-implant infection in a female patient. Two single 10-mm-long maxillary implants placed in the posterior region were lost due to body fracture. The cumulative 5-year survival rate of the implants was 93.75 %. The most common prosthetic complication was loosening of the occlusal screw.Conclusion: Within the limited observation period and the number of patients included in this study, it may be concluded that the use of small-diameter implants appears to be predictable if clinical guidelines are followed and appropriate prosthetic restorations are provided. However, it should be noted that fatigue fracture may occur.

  8. Under-5 Year Mortality: Result of In-Hospital Study, Tehran, Iran

    Nojomi Marzieh

    2009-10-01

    Full Text Available In July 2003, the Bellagio Study Group on Child Survival estimated that the lives of 6 million children could be saved each year if 23 proven interventions were universally available in the 42 countries re-sponsible for 90% of child deaths in 2000. The aim of this study was to determine frequency of important causes of mortality among under-5 year old children in hospitals, Tehran, Iran. Information about Mortality data of under-5 year old children from 16 hospitals in the West of Tehran was collected. The study period was conducted from 1 October 2005 to 30 March 2006. Educated health personnel in each hospital interviewed parents of children who died in hospital and filled out a checklist. 142 under-5 year old children died over the course of study, of whom, 118 (83% were neonates (under 28 days-old, 53.5% had low birth weights (< 2500 Kg, 62 (43% were girls and 80 (57% boys. The most common cause of under-5 year death was due to certain conditions originating in the perinatal period (ICD-10: P00-P96 (68%. Congenital abnormalities (12% and pneumonia (5% were the second and third most common causes respectively. Among 28-day to one-year old children, the leading cause of death was pneumonia (27.3%, while for children being 1 to 5 years of age, this included pneumonia and chronic hepatitis (about 30%. Overall, the most common causes of death were disorders related to short gestation and low birth weight. Therefore, achievement of the millennium development goal of reducing child mortality by two-thirds from 1990 rate will depend on renewed efforts to prevent and control low birth weight, preterm delivery, pneumonia, and infectious diseases in our setting.

  9. 5-year Mortality in Hemodialysis Patients: A Single Center Study in Tripoli

    Buargub Mahdia

    2008-01-01

    Full Text Available To investigate the 5-year mortality of patients undergoing maintenance hemo-dialysis (HD at Al-Shat center Tripoli, we reviewed during June 2007 the records of all the HD patients initiated on HD from Jun 2000 and Jan 2002.There were 124 patients in the study, 77 males (63.6% and 47 (36.4% females, with a mean age of 49 ± 14 years. Diabetic nephropathy (DN was the underlying kidney disease in 34 (27.4% patients. After 5 years; 3 patients were transferred to other centers, 18 (14.9% patients underwent kidney transplan-tation. Out of the 103 patients who continued on hemodialysis, 53 (51.4% expired during the 5-year follow-up. Mortality was associated with older age (p< 0.001 and odd ratio (OR of 4.2 for age > 50 years and DN (p< 0.002 and OR of 3.9. Mortality rate in diabetics was 74.1% and significantly associated with male sex (p< 0.0067 and OR of 2.4, older age (p< 0.004, presence of hypertension (p< 0.003 and OR of 3.9, type 1 diabetes (OR 1.6, and elevated mean body weight (p< 0.046. Mortality was also relatively higher in black patients (OR of 2.0 and smokers (OR of 1.39. In conclusion, the overall 5- year mortality for dialysis patients was elevated and higher in the diabetics.

  10. Fertility issues in Simmental cows in Central Croatia: a 5-year study

    Zobel, Robert; TKALCIC, Suzana; COLE, Wendell

    2013-01-01

    The purpose of this study was to establish the fertility trends in dairy cows in Central Croatia and compare the trends and causes of infertility and subfertility during a 5-year period. A total of 12,060 Simmental cows and heifers were included in the study. The animals were examined by vaginoscopy, transrectal palpation, and ultrasonography on a regular basis. Fertility problems that included infertility and subfertility were diagnosed in 56.61% of all observed animals. The total number of ...

  11. Endocrine dysfunction following traumatic brain injury: a 5-year follow-up nationwide-based study

    Yang, Wei-Hsun; Chen, Pau-Chung; Wang, Ting-Chung; Kuo, Ting-Yu; Cheng, Chun-Yu; Yang, Yao-Hsu

    2016-01-01

    Post-traumatic endocrine dysfunction is a complication of traumatic brain injury (TBI). However, there is lack of long-term follow-up and large sample size studies. This study included patients suffering from TBI registered in the Health Insurance Database. Endocrine disorders were identified using the ICD codes: 244 (acquired hypothyroidism), 253 (pituitary dysfunction), 255 (disorders of the adrenal glands), 258 (polyglandular dysfunction), and 259 (other endocrine disorders) with at least three outpatient visits within 1 year or one admission diagnosis. Overall, 156,945 insured subjects were included in the final analysis. The 1- and 5-year incidence rates of post-traumatic endocrinopathies were 0.4% and 2%, respectively. The risks of developing a common endocrinopathy (p endocrine dysfunction after TBI increased during the entire 5-year follow-up period. Skull bone fracture and intracranial hemorrhage may be associated with short and long-term post-traumatic pituitary dysfunction, respectively. PMID:27608606

  12. Fasting Plasma Insulin at 5 Years of Age Predicted Subsequent Weight Increase in Early Childhood over a 5-Year Period-The Da Qing Children Cohort Study.

    Yan Yan Chen

    Full Text Available The association between hyperinsulinemia and obesity is well known. However, it is uncertain especially in childhood obesity, if initial fasting hyperinsulinemia predicts obesity, or obesity leads to hyperinsulinemia through insulin resistance.To investigate the predictive effect of fasting plasma insulin on subsequent weight change after a 5-year interval in childhood.424 Children from Da Qing city, China, were recruited at 5 years of age and followed up for 5 years. Blood pressure, anthropometric measurements, fasting plasma insulin, glucose and triglycerides were measured at baseline and 5 years later.Fasting plasma insulin at 5 years of age was significantly correlated with change of weight from 5 to 10 years (ΔWeight. Children in the lowest insulin quartile had ΔWeight of 13.08±0.73 kg compare to 18.39±0.86 in the highest insulin quartile (P<0.0001 in boys, and similarly 12.03±0.71 vs 15.80±0.60 kg (P<0.0001 in girls. Multivariate analysis showed that the predictive effect of insulin at 5 years of age on subsequent weight gain over 5 years remained statistically significant even after the adjustment for age, sex, birth weight, TV-viewing time and weight (or body mass index at baseline. By contrast, the initial weight at 5 years of age did not predict subsequent changes in insulin level 5 years later. Children who had both higher fasting insulin and weight at 5 years of age showed much higher levels of systolic blood pressures, fasting plasma glucose, the homeostasis model assessment for insulin resistance (HOMA-IR and triglycerides at 10 years of age.Fasting plasma insulin at 5 years of age predicts weight gain and cardiovascular risk factors 5 year later in Chinese children of early childhood, but the absolute weight at 5 years of age did not predict subsequent change in fasting insulin.

  13. MYOCARDIAL BRIDGING - CLINICAL AND ANGIOGRAPHIC PROFILE IN LAST 5 YEARS; A STUDY OF 129 CASES

    Abhilash S P; Krishna Kumar B; Praveen Velappan; PrabhaniniGupta; Sunita Viswanathan; A. George Koshy

    2010-01-01

    Aims of study : To assess the clinical and angiographical profile of myocardial bridging from consecutive coronary angiograms done over last 5 years at Medical college, Thiruvananthapuram. To assess the risk of cardiovascular events and the risk of accelerated atherosclerosis in isolated myocardial bridging. Methods : Consecutive coronary angiograms done at Medical college Thiruvananthapuram from 04/02/2005 to 31/03/2010 were reviewed for myocardial bridging. A total of 10492 coronary angiogr...

  14. Timing and risk factors for clinical fractures among postmenopausal women: a 5-year prospective study

    Rinkens Paula ELM

    2006-10-01

    Full Text Available Abstract Background Many risk factors for fractures have been documented, including low bone-mineral density (BMD and a history of fractures. However, little is known about the short-term absolute risk (AR of fractures and the timing of clinical fractures. Therefore, we assessed the risk and timing of incident clinical fractures, expressed as 5-year AR, in postmenopausal women. Methods In total, 10 general practice centres participated in this population-based prospective study. Five years after a baseline assessment, which included clinical risk factor evaluation and BMD measurement, 759 postmenopausal women aged between 50 and 80 years, were re-examined, including undergoing an evaluation of clinical fractures after menopause. Risk factors for incident fractures at baseline that were significant in univariate analyses were included in a multivariate Cox survival regression analysis. The significant determinants were used to construct algorithms. Results In the total group, 12.5% (95% confidence interval (CI 10.1–14.9 of the women experienced a new clinical fracture. A previous clinical fracture after menopause and a low BMD (T-score Conclusion In postmenopausal women, clinical fractures cluster in time. One in two women with a recent clinical fracture had a new clinical fracture within 5 years, regardless of BMD. The 5-year AR for a first clinical fracture was much lower and depended on BMD.

  15. A study of mandibular fractures over a 5-year period of time: A retrospective study

    Ashish Vyas

    2014-01-01

    Full Text Available Objective: This study aims to evaluate and compare with the existing literature on the etiology, pattern, gender, and anatomical distribution of mandibular fractures. Materials and Methods: The data of 225 cases were analyzed over a period of 5 years between March 2009 and November 2013. Of this 110 were unilateral, 23 bilateral, 18 symphysis and 74 multiple fractures. Results: Males are more affected than females.The peak incidence rate is occurring in 30-35 years of age group. The most common fracture site is parasymphysis and least common site is ramus of mandible. The most common etiological factor is road traffic accident (RTA (45.3% followed by falls (42.6%, assaults (8.9%, sport injuries (2.2%, and gunshot wounds (0.89%. Conclusion: Thus, we conclude that RTA is the leading cause of mandibular fractures and males are more affected. The most common site is parasymphysis fracture in association with angle fracture. We observed that gender was significantly associated with body and angle fracture (P = 0.04 and significant relationship between etiology with multiple site fracture such as (parasymphysis-angle, (body-condyle, (body-angle, and (symphysis-condyle was observed (P ≤ 0.05.

  16. Study visit carbon sinks Peugeot. Evaluation after 5 years and perspectives

    In the framework of its project of the climatic change control, PSA Peugeot Citroen, decided to involve in the decrease of the carbon dioxide emissions. In parallel to the vehicles consumption decrease and the biofuels utilization, the group developed since 5 years a pilot project of carbon sink. This project aims to study the impact of a trees plantation, at a big scale, on the atmospheric carbon dioxide fixation. This document is a first evaluation after the phase of trees plantation. (A.L.B.)

  17. Gestational Age at Birth and 'Body-Mind' Health at 5 Years of Age: A Population Based Cohort Study.

    Cronin, Frances M; Segurado, Ricardo; McAuliffe, Fionnuala M; Kelleher, Cecily C; Tremblay, Richard E

    2016-01-01

    Numerous studies have identified the effects of prematurity on the neonate's physical health, however few studies have explored the effects of prematurity on both the physical and mental health of the child as they develop. Secondary analysis of data from the Millennium Cohort Study, a longitudinal study of infants (n = 18 818, born 2000-2002 in the United Kingdom) was performed. Effects of gestational age at birth on health outcomes at 5 years were measured using parental rating of their children's general health and severity of behavior problems. The association between parent's general health ratings and behavior problem ratings was low: 86% of those reporting serious behavior problems (5% of the sample, n = 764) rated their child as being in excellent, very good, or good health. Still, a gradient of increasing risk of poorer outcome with decreasing gestational age was observed for a composite health measure (poor/fair health and/or serious behavior problems), suggesting an association with prematurity for this composite assessment of health status. The greatest contribution to the childhood composite health measure at 5 years was for children born at 32-36 weeks gestation: population attributable fractions for having poor outcomes was 3.4% (Bonferroni-adjusted 95% confidence interval 1.1%-6.2%), compared to 1% (0.2-2.3) for birth at less than 32 weeks. Results suggest that preterm children, by school entry, are not only at high risk of physical health problems, but also of behavioral health problems. The recognition of, and response to comprehensive health and well-being outcomes related to prematurity are important in order to correctly plan and deliver adequate paediatric health services and policies. PMID:26975048

  18. Gestational Age at Birth and ‘Body-Mind’ Health at 5 Years of Age: A Population Based Cohort Study

    Segurado, Ricardo; McAuliffe, Fionnuala M.; Kelleher, Cecily C.

    2016-01-01

    Numerous studies have identified the effects of prematurity on the neonate’s physical health, however few studies have explored the effects of prematurity on both the physical and mental health of the child as they develop. Secondary analysis of data from the Millennium Cohort Study, a longitudinal study of infants (n = 18 818, born 2000–2002 in the United Kingdom) was performed. Effects of gestational age at birth on health outcomes at 5 years were measured using parental rating of their children’s general health and severity of behavior problems. The association between parent’s general health ratings and behavior problem ratings was low: 86% of those reporting serious behavior problems (5% of the sample, n = 764) rated their child as being in excellent, very good, or good health. Still, a gradient of increasing risk of poorer outcome with decreasing gestational age was observed for a composite health measure (poor/fair health and/or serious behavior problems), suggesting an association with prematurity for this composite assessment of health status. The greatest contribution to the childhood composite health measure at 5 years was for children born at 32–36 weeks gestation: population attributable fractions for having poor outcomes was 3.4% (Bonferroni-adjusted 95% confidence interval 1.1%–6.2%), compared to 1% (0.2–2.3) for birth at less than 32 weeks. Results suggest that preterm children, by school entry, are not only at high risk of physical health problems, but also of behavioral health problems. The recognition of, and response to comprehensive health and well-being outcomes related to prematurity are important in order to correctly plan and deliver adequate paediatric health services and policies. PMID:26975048

  19. Assessment of dental caries predictors in 6-year-old school children - results from 5-year retrospective cohort study

    Masood Mohd; Yusof Norashikin; Hassan Mohamed Ibrahim; Jaafar Nasruddin

    2012-01-01

    Abstract Background This was a retrospective cohort study undertaken to assess the rate and pattern of dental caries development in 6-year-old school children followed-up for a period of 5 years, and to identify baseline risk factors that were associated with 5 years caries experience in Malaysian children. Methods This 5-years retrospective cohort study comprised primary school children initially aged 6 years in 2004. Caries experience of each child was recorded annually using World Health O...

  20. "Growth Chart Study in Children Under 5 Years Old in Rural Area of Khoramabad Province"

    F Majlesi

    2001-09-01

    Full Text Available Growth chart is the best measure for weight monitoring of children. Most factors that affect child heath show their effect on child weight. This cross sectional and descriptive analytical study was achieved to estimate malnutrition prevalence and effective factors in children under 5 years old in rural area of Khoramabad province. 555 girls and 570 boys were chosen from health houses by cluster sampling. Data were gathered through questionnaires. verbal interviews and child weighing. Nutritional status was estimated via weight/age index and the data were analysed by chi-square test. The results show 7.7% malnutrition among the children in this area. Factors that influence the nutritional status were: Frequency of diarrhea and acute respiratory infection, birth weight, duration of breast feeding and milk formula.

  1. Antenatal hydronephrosis: Negative predictive value of normal postnatal ultrasound - a 5-year study

    Moorthy, I.; Joshi, N.; Cook, J.V. E-mail: jcook@epsom-sthelier.nhs.uk; Warren, M

    2003-12-01

    AIM: To determine whether normal postnatal ultrasound, as part of a strict screening protocol for the detection and follow-up of antenatal hydronephrosis, effectively excludes the majority of babies with congenital urinary tract abnormalities that would otherwise present with a urinary tract infection. MATERIALS AND METHODS: We retrospectively reviewed all babies who had postnatal follow-up of antenatally detected hydronephrosis over a 5-year period at our institution, a district general Trust with a specialist paediatric unit. We then studied all babies presenting with urinary tract infection before their first birthday to our institution over the same period. By cross-referencing these two study groups we were able to determine which babies developed a urinary tract infection having been previously discharged after normal postnatal ultrasound. RESULTS: Four hundred and twenty-five babies had postnatal follow-up of antenatal hydronephrosis. Of these, 284 were investigated with ultrasound alone. In the same 5-year period, 230 babies presented with urinary tract infection before their first birthday. Only three of these babies had been previously discharged after normal postnatal ultrasound. The negative predictive value of a normal postnatal ultrasound was therefore 98.9% (281/284) for babies who subsequently presented with a urinary tract infection before their first birthday. CONCLUSION: Careful antenatal and postnatal ultrasound with strict protocols is effective in detecting congenital renal tract abnormalities. Infants discharged after normal postnatal ultrasound are highly unlikely to still have an undetected urinary tract abnormality. We suggest that all babies with antenatal hydronephrosis are started on prophylactic antibiotics at birth, pending further investigation. All babies without features of severe obstruction antenatally should have their postnatal ultrasound delayed for a month. We recommend selective use of micturating cystourethrogram (MCUG

  2. Antenatal hydronephrosis: Negative predictive value of normal postnatal ultrasound - a 5-year study

    AIM: To determine whether normal postnatal ultrasound, as part of a strict screening protocol for the detection and follow-up of antenatal hydronephrosis, effectively excludes the majority of babies with congenital urinary tract abnormalities that would otherwise present with a urinary tract infection. MATERIALS AND METHODS: We retrospectively reviewed all babies who had postnatal follow-up of antenatally detected hydronephrosis over a 5-year period at our institution, a district general Trust with a specialist paediatric unit. We then studied all babies presenting with urinary tract infection before their first birthday to our institution over the same period. By cross-referencing these two study groups we were able to determine which babies developed a urinary tract infection having been previously discharged after normal postnatal ultrasound. RESULTS: Four hundred and twenty-five babies had postnatal follow-up of antenatal hydronephrosis. Of these, 284 were investigated with ultrasound alone. In the same 5-year period, 230 babies presented with urinary tract infection before their first birthday. Only three of these babies had been previously discharged after normal postnatal ultrasound. The negative predictive value of a normal postnatal ultrasound was therefore 98.9% (281/284) for babies who subsequently presented with a urinary tract infection before their first birthday. CONCLUSION: Careful antenatal and postnatal ultrasound with strict protocols is effective in detecting congenital renal tract abnormalities. Infants discharged after normal postnatal ultrasound are highly unlikely to still have an undetected urinary tract abnormality. We suggest that all babies with antenatal hydronephrosis are started on prophylactic antibiotics at birth, pending further investigation. All babies without features of severe obstruction antenatally should have their postnatal ultrasound delayed for a month. We recommend selective use of micturating cystourethrogram (MCUG

  3. A 5 Year Study of Carbon Fluxes from a Restored English Blanket Bog

    Worrall, F.; Dixon, S.; Evans, M.

    2014-12-01

    This study aimed to measure the effects of ecological restoration on blanket peat water table depths, DOC concentrations and CO2 fluxes. In April 2003 the Bleaklow Plateau, an extensive area of deep blanket peat in the Peak District National Park, northern England, was devegetated by a wildfire. As a result the area was selected for large scale restoration. In this study we considered a 5-year study of four restored sites in comparison to both an unrestored, bare peat control and to vegetated control that did not require restoration. Results suggested that sites with revegetation alongside slope stabilisation had the highest rates of photosynthesis and were the largest net (daylight hours) sinks of CO2. Bare sites were the largest net sources of CO2 and had the deepest water table depths. Sites with gully wall stabilisation were between 5-8 times more likely to be net CO2 sinks than the bare sites. Revegetation without gully flow blocking using plastic dams did not have a large effect on water table depths in and around the gullies investigated whereas a blocked gully had water table depths comparable to a naturally revegetating gully. A ten centimetre lowering in water table depth decreased the probability of observing a net CO2 sink, on a given site, by up to 30%. With respect to DOC the study showed that the average soil porewater DOC concentration on the restored sites rose significantly over the 5 year study representing a 34% increase relative to the vegetated control and an 11% increase relative to the unrestored, bare control. Soil pore water concentrations were not significantly different from surface runoff DOC concentrations and therefore restoration as conducted by this study would have contributed to water quality deterioration in the catchment. The most important conclusion of this research was that restoration interventions were apparently effective at increasing the likelihood of net CO2 sink behaviour and raising water tables on degraded

  4. What happens to cavitated primary teeth over time? A 3.5-year prospective cohort study in China

    Hu, X.; Chen, X.; Fan, M.; Mulder, J.; Frencken, J.E.F.M.

    2013-01-01

    OBJECTIVES: Data showed that among 5-year-old Chinese, 96.7% of cavitated primary teeth were left untreated. The study aimed to report on the course of cavitated primary teeth within the Chinese health-care system over a period of 3.5 years. METHODS: Selection of high caries risk children for inclus

  5. Survival Rate of Short, Locking Taper Implants with a Plateau Design: A 5-Year Retrospective Study

    Kemal Özgür Demiralp

    2015-01-01

    Full Text Available Background. Short implants have become popular in the reconstruction of jaws, especially in cases with limited bone height. Shorter implants, those with locking tapers and plateau root shapes, tend to have longer survival times. We retrospectively investigated the cumulative survival rates of Bicon short implants (<8 mm according to patient variables over a 5-year period. Materials and Methods. This study included 111 consecutively treated patients with 371 implants supporting fixed or removable prosthetics. Data were evaluated to acquire cumulative survival rates according to gender, age, tobacco use, surgical procedure, bone quality, and restoration type. Statistics were performed using chi-square, Mann-Whitney, and Kruskal Wallis H tests. Results. The survival rate was 97.3% with, on average, 22.8 months of follow-up. Patients older than 60 years had higher failure rate than the other age groups (P<0.05. Placed region, age, and bone quality had adverse effects on survival rate in the <8 mm implant group with statistically significant difference (P<0.05. Conclusions. Approximately 23-month follow-up data indicate that short implants with locking tapers and plateau-type roots have comparable survival rates as other types of dental implants. However, due to limitations of study, these issues remain to be further investigated in future randomized controlled clinical trials.

  6. A 5-year follow-up study of an atypical case of myotonic dystrophy.

    Macniven, J A B; Graham, N L; Davies, R R; Wilson, B A

    2005-12-20

    This study presents 5-year follow-up data on NG, a woman with adult onset myotonic dystrophy and progressive cognitive decline who was first described by Wilson et al. The extent of the cognitive impairment is atypical of symptom-onset in adulthood and of paternal inheritance, both of which apply to this case. Together, the present and earlier studies report the results of regular neuropsychological assessments over a 16-year period. Severe impairment in executive functioning, episodic and semantic memory were apparent early in the history, while visuospatial skills and working memory were only mildly impaired after 16 years of follow-up. There was also a progressive dyslexia, initially characterized by the regularization errors typical of surface dyslexia, but subsequently dominated by visual/phonological reading errors. This pattern of impairment is not typical of myotonic dystrophy but resembles semantic dementia. Whilst the deficits may be attributable wholly to myotonic dystrophy pathology, the co-existence of a form of semantic dementia is also possible. It is noted that the aggregation of tau protein is a neuropathological feature common to both diseases. PMID:16286337

  7. Posterior bulk-filled resin composite restorations. A 5-year randomized controlled clinical study

    Dijken, Jan WVvan; Pallesen, Ulla

    2016-01-01

    as needed to fill the cavity 2mm short of the occlusal cavosurface. The occlusal part was completed with the nano-hybrid resin composite (Ceram X mono+). In the other cavity, the resin composite-only (Ceram X mono+) was placed in 2mm increments. The restorations were evaluated using slightly modified......OBJECTIVE: To evaluate in a randomized controlled study the 5-year clinical durability of a flowable resin composite bulk-fill technique in Class I and Class II restorations. MATERIAL AND METHODS: 38 pairs Class I and 62 pairs Class II restorations were placed in 44 male and 42 female (mean age 52.......4 years). Each patient received at least two, as similar as possible, extended Class I or Class II restorations. In all cavities, a 1-step self-etch adhesive (Xeno V+) was applied. Randomized, one of the cavities of each pair received the flowable bulk-filled resin composite (SDR), in increments up to 4mm...

  8. Implications of Foot Ulceration in Hemodialysis Patients: A 5-Year Observational Study

    Hassan Al-Thani

    2014-01-01

    Full Text Available Foot ulceration (FU remains a serious concern for patients worldwide. We analyzed the incidence, risk factors, and outcome of FU in hemodialysis (HD patients. A retrospective cohort study was conducted for 252 HD patients who were followed up for 5 years. Patients were categorized according to whether they developed FU or not. The FU group (17% was older and had significantly higher incidence of nephropathy, retinopathy, peripheral (PAD, coronary artery disease (CAD, and diabetes mellitus (DM as compared to no-FU group. FU group had higher frequency of major amputation (P=0.001 and HD vascular access (P=0.01. Patients with combined DM and PAD had a 10-fold increased risk of FU in comparison to those who had DM alone. Presence of PAD was the main independent predictor for development of FU in HD with an adjusted odd ratio (aOR of 16.0 (95% CI: 4.41–62.18; P=0.001. After adjusting for age, sex, and CAD, predictors for mortality were PAD (aOR 4.3, FU (aOR 3.6, and DM (aOR 2.6. FU is common in HD patients regardless of DM. However, the presence of PAD is significantly associated with more FU and mortality in HD. HD patients need intensive foot care and warrant progressive modification of vascular risk factors.

  9. PERIPARTUM HY STERECTOMY: A LIMITING FACTOR FOR PROCREATIVE POTENTIAL & SAFE - MOTHERHOOD: A 5 YEARS RETROSPECTIVE STUDY

    Agnes Vijaya

    2015-09-01

    Full Text Available BACKGROUND : The term hysterectomy means surgical removal of uterus it can be either along with cervix or adnexae through different routes. The most commonly performed major elective gynecological surgery. The term Peripartum hysterectomy is used when performed either mostly by emergency as a maternal life saving measure within 24 hours after vaginal or abdominal delivery or as electively when indicated. OBJECTIVE : To study the incidence of peripartum hysterectomy ; to analyze its causes, risk factors, complications and feto - maternal morbidity and mortality at newly established tertiary care teaching hospital. PLACE OF STUDY : Rajiv Gandhi Institute of Medical Sciences (RIMS, Kadapa, YSR district, Andhra Pradesh, South India. DESIGN AND DURATION : Retrospective study of 5 years period, Jan . ’2010 to Dec . ’2014. MATERIALS AND METHODS : 42 cases of peripartum hysterectomised patients medical records reviewed for characteristics of current pregnancy and delivery, indications for peripartum hysterectomy, operative and post - operative complications, maternal and perinatal outcome evaluated. RESULTS : 42 cases of peripartum hysterectomy identified out of 32398 total deliveries (1.3 in 1000. Among them 23 cases was Laparotomy for rupture uterus, Caesarean hysterectomy in 12 cases, followed by vaginal delivery in 6 cases and for chronic ectopic pregnancy with bilateral T.O. mass in 1 case (P2 L2 +Bil. T. with chronic ectopic for failed tubectomy. No Live Children in 9 cases & 1 Live Child in 19 cases were identified and 2 or more Live Children in 14 cases. CONCLUSIONS : The incidence of peripartum hysterectomy is similar to the data found in studies of other Asian countries. Most frequent indication being rupture uterus leading to high perinatal, maternal mortality and morbidity limiting the child bearing capacity (Procreative Potential. To reduce this high incidence of peripartum hysterectomy effective MCH services to be exercised at all the

  10. A study of profile of disability certificate seeking patients with schizophrenia over a 5 year period

    Yatan Pal Singh Balhara

    2013-01-01

    Full Text Available Background: Schizophrenia has been identified as one of the most disabling condition known to mankind. Until recently there was no published literature on disability certification seeking behavior of patients diagnosed with schizophrenia. The current study aimed at understanding the profile of patients diagnosed with schizophrenia seeking disability certification for a tertiary level multispecialty hospital in India. Materials a nd Methods: The study was carried out at the Psychiatry department for a tertiary care hospital in India. The evaluation of the subjects was carried out in the presence of a primary care giver. First, the diagnosis was established using International Statistical Classification of Diseases and Related Health Conditions (ICD-10. Subsequently, the disability was assessed using Indian Disability Evaluation Assessment Scale (IDEAS. Data were analyzed using SPSS (Statistical Package for Social Sciences software version 17. Results: A total of 169 subjects seeking disability certification over the study period of 5 years were diagnosed with schizophrenia. Out of 169 subjects 132 (78.1% were male and 37 (21.9% were female. There was a statistically significant difference in the marital status of the male and female study subjects. Family history of psychiatric illness was positive in 9.8% of male subjects and 10.8% of female subjects. There was no significant difference between male and female subjects for the duration of illness and duration of being on treatment. Male and female subjects did not differ significantly on the IDEAS global score, personal care, interpersonal interaction, and understanding and communication domains of IDEAS. The two groups differed significantly on the work domain. Conclusions: Majority of patients with schizophrenia seeking disability certificate continue to be male. However, male and female subjects tend to differ very little on various socio-demographic and illness related variables. The levels

  11. Leprosy scenario at a tertiary level hospital in Delhi: A 5-year retrospective study

    Namrata Chhabra

    2015-01-01

    Full Text Available Background: Leprosy has been officially eliminated from India since December, 2005; still, there are districts and blocks reporting high prevalence indicating ongoing transmission. The present study aimed at determining the current clinical profile of leprosy from a tertiary level hospital in Delhi. Materials and Methods: A retrospective, record-based study was carried out on patients diagnosed and registered in the leprosy clinic of a tertiary level teaching hospital in East district of Delhi (April 2007 to March 2012. Data regarding demographic details, clinical features, treatment started and complications was analyzed. Results: A total of 849 patients were registered over a 5-year period, with M: F ratio of 2.3:1. 9.3% were children (ͳ14 years. 54.3% patients were immigrants from adjoining states. Multibacillary leprosy was the most common clinical type (86.9%. Borderline tuberculoid leprosy was the most frequent morphologic type, seen in 56.3% followed by borderline-borderline (1.5%, borderline lepromatous (24.9%, lepromatous leprosy (8.1%, pure neuritic (8.1%, histoid and indeterminate leprosy (0.5% each. 37.4% patients presented in reaction (Type I in 30.4% cases and Type II in 7% cases. WHO grade II deformities were diagnosed in 37.9% with claw hand being the most common paralytic deformity (23.3% cases. Conclusion: Our study offers insight into the current status of the disease in an area of otherwise low prevalence. It is seen that despite statistical elimination, multibacillary disease, leprosy reactions and deformities are commonly seen as presenting manifestations, in contrast to national projected trends. Delhi′s unique demography with a high degree of migrant workers, presenting to our center (near border location could be a possible contributing factor towards these aberrations. It highlights the need for continuation of targeted leprosy control activities and active case detection.

  12. A Multidimensional Scaling Study of Visual Memory of 5-Year Olds and Adults

    Arabie, Phipps; And Others

    1975-01-01

    An investigation of memory development using nonmetric multidimensional scaling. Judgments of similarities between complex objects were obtained from 5-year-olds and adults under two conditions: (1) when objects were simultaneously present at the time of comparison, and (2) when the objects were not simultaneously present and had to be compared on…

  13. Efficacy and safety of raltegravir for treatment of HIV for 5 years in the BENCHMRK studies

    Eron, Joseph J; Cooper, David A; Steigbigel, Roy T; Clotet, Bonaventura; Gatell, Jose M; Kumar, Princy N; Rockstroh, Jurgen K; Schechter, Mauro; Markowitz, Martin; Yeni, Patrick; Loutfy, Mona R; Lazzarin, Adriano; Lennox, Jeffrey L; Strohmaier, Kim M; Wan, Hong; Barnard, Richard Jo; Nguyen, Bach-Yen T; Teppler, Hedy; Pedersen, Court

    2013-01-01

    Two randomised, placebo-controlled trials-BENCHMRK-1 and BENCHMRK-2-investigated the efficacy and safety of raltegravir, an HIV-1 integrase strand-transfer inhibitor. We report final results of BENCHMRK-1 and BENCHMRK-2 combined at 3 years (the end of the double-blind phase) and 5 years (the end ...

  14. MYOCARDIAL BRIDGING - CLINICAL AND ANGIOGRAPHIC PROFILE IN LAST 5 YEARS; A STUDY OF 129 CASES

    Abhilash S P

    2010-11-01

    Full Text Available Aims of study : To assess the clinical and angiographical profile of myocardial bridging from consecutive coronary angiograms done over last 5 years at Medical college, Thiruvananthapuram. To assess the risk of cardiovascular events and the risk of accelerated atherosclerosis in isolated myocardial bridging. Methods : Consecutive coronary angiograms done at Medical college Thiruvananthapuram from 04/02/2005 to 31/03/2010 were reviewed for myocardial bridging. A total of 10492 coronary angiograms were reviewed. Myocardial bridges with systolic lumen reduction of more than 50% were considered for analysis. Quantitative coronary angiography (QCA was used for analysis. Clinical presentation as well as correlation with structural heart disease and coronary heart disease was assessed. Results: Incidence of myocardial bridges was 1.23%. Of the 129 patients with myocardial bridges 63 ( 48.8% had associated significant coronary artery disease. Remaining 66 (51.2% patients presented with isolated bridges. Out of these 66 patients with isolated myocardial bridges, 7 (10.6% patients presented with acute myocardial infarction and 3 (4.5% presented with cardiac arrhythmias. Of the 63 patients with significant coronary disease 11 (17.5% patients had single vessel disease and they had the culprit lesion and myocardial bridge seen in the same vessel. Most common location of myocardial bridge was mid LAD (64.9% followed by distal LAD (23.8%. Length of bridge was 20 mm in 35.7%. Mean percentage of systolic obliteration by the bridge was 74.5%. 100% systolic obliteration was seen in 7.79% of isolated bridges and in 9.79% of bridges with CAD. Among 120 rhuematic heart disease patients who underwent coronary angiogram, 10 (8.3% patients had myocardial bridging. 12.1% of all HCM patients who underwent coronary angiograms had myocardial bridging. Conclusion: Myocardial bridging can be lethal- can accelerate atherosclerosis, can precipitate acute MIs and life

  15. Granulomatous reaction - a histopathological study: a retrospective and prospective study of 5 years

    Khyati Ranchhodbhai Babaria; Amit H Agravat; Gauravi A Dhruva

    2015-01-01

    Background: The present study was done to investigate the prevalence of granulomatous infection among the patients. The study was conducted from the time period of July 2008 to June 2013. The study was conducted at the histopathology laboratory, pathology department, P. D. U. government medical college, Rajkot (Gujarat, India). Methods: In the present study, total 300 cases were studied. Specimens for study were received from various departments like surgery, ENT, medicine, pediatrics etc...

  16. Ethnic Background and Overweight among 5-Year-Old Children: The “Be Active, Eat Right” Study

    Lydian Veldhuis; Mara van Dooremaal; Willemieke Kroeze; Renders, Carry M; Hirasing, Remy A.; Hein Raat

    2013-01-01

    Introduction. This study investigates the association between ethnic background and overweight (obesity included) among 5 year olds. Methods. We used baseline data from 5 year olds (n = 7801) and their parents collected for the “Be active, eat right” study. A child was considered to be of non-Dutch ethnic background when at least one of the parents was born abroad. Odds ratios (ORs) were adjusted for sociodemographic characteristics. Results. Compared to children of Dutch ethnic background, f...

  17. A 5-year follow-up study of Alfredson's heel-drop exercise programme in chronic midportion Achilles tendinopathy

    2011-01-01

    Background Eccentric exercises have the most evidence in conservative treatment of midportion Achilles tendinopathy. Although short-term studies show significant improvement, little is known of the long-term (>3 years) results. Aim To evaluate the 5-year outcome of patients with chronic midportion Achilles tendinopathy treated with the classical Alfredson's heel-drop exercise programme. Study design Part of a 5-year follow-up of a previously conducted randomised controlled trial. Methods 58 p...

  18. A 5-year follow-up study of Alfredson's heel-drop exercise programme in chronic midportion Achilles tendinopathy

    Plas, J.F.A.N.; Jonge, Suzan; Vos, Robert-Jan; Van der Heide, H.J.L.; Verhaar, Jan; Weir, Adam; Tol, Johannes

    2012-01-01

    textabstractBackground: Eccentric exercises have the most evidence in conservative treatment of midportion Achilles tendinopathy. Although short-term studies show significant improvement, little is known of the long-term (>3 years) results. Aim: To evaluate the 5-year outcome of patients with chronic midportion Achilles tendinopathy treated with the classical Alfredson's heel-drop exercise programme. Study design: Part of a 5-year follow-up of a previously conducted randomised controlled tria...

  19. Granulomatous reaction - a histopathological study: a retrospective and prospective study of 5 years

    Khyati Ranchhodbhai Babaria

    2015-01-01

    Conclusion: Our study confirms that the most common granulomatous reaction is tuberculosis, mainly found in skin and more common among the population of lower socioeconomic class and rural population, signifying increasing incidence of granulomation infection. The present study is a comprehensive comparative study of granulomatous reactions done in correlation with the age, sex, involved sites and clinical profile of the patients. This information is valuable in policy formation for the control and specific treatment and outcome of granulomatous infection. [Int J Res Med Sci 2015; 3(1.000: 201-206

  20. A Comparative Study on Motor Skills in 5-Year-Old Children with Phonological and Phonetic Disorders

    Fatemeh Hasanati; Ahmad Reza Khatoonabadi; Mehdi Abdolvahab

    2011-01-01

    Background and Aim: Speech as a motor phenomenon requires repetitive and rapid function of articulatory organs performing extremely fine movements. Practice on motor skills results in facilitation in treatment progress of children with phonological disorders. The purpose of this study was to compare motor skills in 5-year-old children with phonological and phonetic disorders.Methods: Thirty-two children age 5 years, 16 with phonemical speech sound disorders and 16 with difficulty at a phoneti...

  1. A 5-year prospective observational study of the outcomes of international treatment guidelines for Crohn's disease.

    Cullen, Garret

    2012-02-01

    BACKGROUND & AIMS: Therapeutic strategies for patients with Crohn\\'s disease are based on American and European guidelines. High rates of corticosteroid dependency and low remission rates are identified as weaknesses of this therapy and as justification for early introduction of biologic agents (top-down treatment) in moderate\\/severe Crohn\\'s disease. We reviewed outcomes and corticosteroid-dependency rates of patients with moderate-to-severe disease who were treated according to the international guidelines. METHODS: Consecutive patients (102) newly diagnosed with Crohn\\'s disease in 2000-2002 were identified from a prospectively maintained database. Severity of disease was scored using the Harvey-Bradshaw Index (HBI). Disease was classified by Montreal classification. Five-year follow-up data were recorded. RESULTS: Seventy-two patients had moderate\\/severe disease at diagnosis (HBI >8). Fifty-four (75%) had nonstricturing, nonpenetrating disease (B1). Sixty-four (89%) received corticosteroids, and 44 (61%) received immunomodulators. Twenty-one patients (29%) received infliximab. Thirty-nine patients (54%) required resection surgery. At a median of 5 years, 66 of 72 (92%) patients with moderate\\/severe disease were in remission (median HBI, 1). Twenty-five patients (35%) required neither surgery nor biologic therapy. CONCLUSIONS: When international treatment guidelines are strictly followed, Crohn\\'s disease patients can achieve high rates of remission and low rates of morbidity at 5 years. Indiscriminate use of biologic agents therefore is not appropriate for all patients with moderate-to-severe disease.

  2. Stable glomerular filtration rate in normotensive IDDM patients with stable microalbuminuria. A 5-year prospective study

    Mathiesen, E R; Feldt-Rasmussen, B; Hommel, E; Deckert, T; Parving, H H

    1997-01-01

    patients with persistent microalbuminuria (mean urinary albumin excretion [UAE] 84 mg/24 h [range 30-300]) were followed prospectively for 5 years of clinical examinations that included the measurement of GFR (51Cr-labeled EDTA clearance) at least once a year. The mean GFR at baseline was 120 +/- 18 ml x...... min-1.1 x 73 m-2. RESULTS: Using multiple regression analysis, the rate of decline in GFR was independently correlated to onset of diabetic nephropathy (P < 0.001) and systolic blood pressure (sBP) at baseline (P < 0.05). Increase in UAE was correlated to the mean HbA1c during the observation period...

  3. Superselective radioembolization of hepatocellular carcinoma: 5-year results of a prospective study.

    Rösler, H; Triller, J; Baer, H U; Geiger, L; Beer, H F; Becker, C; Blumgart, L H

    1994-10-01

    Twenty patients with unresectable hepatocellular carcinoma (HCC) were followed up to 5 years after transarterial radiotherapy with 90Y-resin particles. Diagnostic radioembolizations of 99mTc-macroaggregates facilitated scintigraphic assessment of activity distribution, dose evaluation and final procedural verification. The overall survival rates were 56, 38 and 14% (after 1, 2 and 3 years, resp.). Patients with unifocal HCC and a single feeding artery (n = 7) even presented 83, 67 and 40% (2 alive after 2.75 and 4 years). With multiple arteries (n = 7), the longest survival was 26 months. Patients with multifocal HCC survived up to 33 months after selective radioembolization. Quality of life was improved in all. Survival was positively correlated with absorbed dose but residual/recurrent tumour occurred even after > or = 300 Gy. Post-treatment symptoms were minimal (35 applications), pulmonary shunt rates were correctly predicted and pulmonary complications avoided. PMID:7997379

  4. Superselective radioembolization of hepatocellular carcinoma: 5-year results of a prospective study

    Roesler, H. (Dept. of Nuclear Medicine, Paul Scherrer-Inst., Villigen (Switzerland)); Triller, J. (Dept. of Diagnostic Radiology, Paul Scherrer-Inst., Villigen (Switzerland)); Baer, H.U. (Clinic of Visceral Surgery, Paul Scherrer-Inst., Villigen (Switzerland)); Geiger, L. (Dept. of Nuclear Medicine, Paul Scherrer-Inst., Villigen (Switzerland)); Beer, H.F. (Paul Scherrer-Inst., Villigen (Switzerland)); Becker, C. (Dept. of Diagnostic Radiology, Paul Scherrer-Inst., Villigen (Switzerland)); Blumgart, L.H. (Clinic of Visceral Surgery, Paul Scherrer-Inst., Villigen (Switzerland))

    1994-10-01

    Twenty patients with unresectable hepatocellular carcinoma (HCC) were followed up to 5 years after transarterial radiotherapy with [sup 90]Y-resin particles. Diagnostic radioembolizations of [sup 99m]Tc-macroaggregates facilitated scintigraphic assessment of activity distribution, dose evaluation and final procedural verification. The overall survival rates were 56, 38 and 14% (after 1, 2 and 3 years, resp.). Patients with unifocal HCC and a single feeding artery (n = 7) even presented 83, 67 and 40% (2 alive after 2.75 and 4 years). With multiple arteries (n = 7), the longest survival was 26 months. Patients with multifocal HCC survived up to 33 months after selective radioembolization. Quality of life was improved in all. Survival was positively correlated with absorbed dose but residual/recurrent tumor occurred even after [>=]300 Gy. Post-treatment symptoms were minimal (35 applications), pulmonary shunt rates were correctly predicted and pulmonary complications avoided. (orig.)

  5. Cardiovascular risk factors and 5-year mortality in the Copenhagen Stroke Study

    Kammersgaard, Lars Peter; Olsen, Tom Skyhøj

    2005-01-01

    Cox proportional hazards analyses adjusted for age, gender, stroke severity, and risk factor profile. RESULTS: In Kaplan-Meier analyses atrial fibrillation (AF), ischemic heart disease, diabetes, and previous stroke were associated with increased mortality, while smoking and alcohol intake were...... associated with decreased mortality. No association was found for hypertension or intermittent claudication. In the final Cox proportional hazard model predictors of 5-year mortality were AF (hazard ratio, HR 1.4; 95% CI 1.1-1.7), diabetes (HR 1.3; 95% CI 1.0-1.6), smoking (HR 1.2; 95% CI 1.0-1.4), and...... previous stroke (HR 1.4; 95% CI 1.1-1.7), after adjustment for age, gender, and stroke severity. CONCLUSIONS: AF, diabetes, smoking, and previous stroke significantly affect long-term survival. Although smoking and daily alcohol consumption appeared to be associated with improved survival in the univariate...

  6. STUDY OF THE CAUSES OF MORTALITY IN CHILDREN UNDER 5 YEARS OF AGE IN CHAHARMAHAL AND BAKHTIYARI PROVINCE, IRAN

    F. Majlessi

    2000-12-01

    Full Text Available In this study the causes of mortality in children less than 5 years of age has been investigated. In this retrospective cross-sectional study, results were analysed by a descriptive analytic method. The investigation was carried out among 597 children less than 5 years including 296 boys and 301 girls. The sample was selected by census method and the necessary information was collected using questionnaire and documented family records in the local health houses. The results of interviews and filed records showed that the prevalent causes of mortality in children under 5 years in this area were prematurely in order of decreasing, low birth weight, respiratory infections, accidents, non-contiguous and diarrhoeal diseases. About one-fourth of the causes of mortality still remain unknown.

  7. Implant-supported mandibular overdentures retained with ball or bar attachments: a randomized prospective 5-year study

    Gotfredsen, K; Holm, B

    2001-01-01

    PURPOSE: The aim of the present study was to evaluate the periimplant conditions and the maintenance requirements for implant-supported overdentures in the mandible retained with ball or bar attachments during a 5-year period. MATERIALS AND METHODS: Twenty-six completely edentulous patients had two...... Astra Tech dental implants placed in the anterior part of the mandible. The denture attachment system for the patients was chosen randomly by drawing lots. Eleven patients drew the bar attachment system and fifteen patients drew the ball attachment system. Plaque Index, Gingival Index, and probing...... differences were registered. The mean frequency of complications/repairs per patient per year was 1.0 in the bar group and 0.6 in the ball group during the 5-year observation period. CONCLUSION: Two implants with ball or bar attachment supported an overdenture in the mandible for 5 years with a 100% survival...

  8. Aging in Rett syndrome: a longitudinal study.

    Halbach, N S J; Smeets, E E J; Steinbusch, C; Maaskant, M A; van Waardenburg, D; Curfs, L M G

    2013-09-01

    Little is known about the aging process of people with specific syndromes, like Rett syndrome (RTT). Recognition of the clinical and behavioral characteristics of the adult RTT is needed in order to improve future management of the RTT girl and counseling of parents. In association with the Dutch RTT parent association, a 5-year longitudinal study was carried out. The study population consisted of 53 adult women with a clinical diagnosis of RTT. Postal questionnaires were sent, including demographic features, skills, physical and psychiatric morbidity. At the time of the second measurement seven women had died. In 2012, 80% of the questionnaires (37/46) were returned. Mean age of the women was 31.4 years. Molecular confirmation was possible for 83% of the women for whom analyses were carried out. The adult RTT woman has a more or less stable condition. The general disorder profile is that of a slow on-going deterioration of gross motor functioning in contrast to a better preserved cognitive functioning, less autonomic and epileptic features and good general health. This is the first longitudinal cohort study about aging in RTT. Continuing longitudinal studies are needed to gain more insight into the aging process in RTT. PMID:23167724

  9. A 5-year prospective study of single-tooth replacements supported by the Astra Tech implant: a pilot study

    Gotfredsen, Klaus

    2004-01-01

    BACKGROUND: Implant-supported single-tooth replacements are an increasingly used method to replace teeth, especially in young patients. Therefore, long-term validation of different treatment modalities with different implant systems is of great importance. PURPOSE: The aim of the present study wa......: Implant-supported single-tooth replacement with the Astra Tech system is a reliable treatment resulting in a good 5-year prognosis and only few complications.......BACKGROUND: Implant-supported single-tooth replacements are an increasingly used method to replace teeth, especially in young patients. Therefore, long-term validation of different treatment modalities with different implant systems is of great importance. PURPOSE: The aim of the present study was...... bone adjacent to implants and neighboring teeth was less than 0.5 mm during the 5-year period, and there was no significant difference after crown placement between the treatment modality for group A and that for B. There were fewer clinical complications and repairs in group B than in group A. Soft...

  10. Parenting style, the home environment, and screen time of 5-year-old children; the 'be active, eat right' study

    Veldhuis, Lydian; van Grieken, Amy; Renders, Carry; HiraSing, Remy; Raat, Hein

    2014-01-01

    textabstractIntroduction: The global increase in childhood overweight and obesity has been ascribed partly to increases in children's screen time. Parents have a large influence on their children's screen time. Studies investigating parenting and early childhood screen time are limited. In this study, we investigated associations of parenting style and the social and physical home environment on watching TV and using computers or game consoles among 5-year-old children. Methods: This study us...

  11. Does Parenting Shield Youth from Exposure to Violence during Adolescence? A 5-Year Longitudinal Test in a High-Poverty Sample of Minority Youth

    Spano, Richard; Rivera, Craig; Bolland, John M.

    2011-01-01

    Five waves of longitudinal data collected from 349 African American youth living in extreme poverty were used to determine if parental monitoring shielded youth from exposure to violence during adolescence. Semiparametric group-based modeling was used to identify trajectories of parental monitoring and exposure to violence from T1 to T5. Results…

  12. Assessment of dental caries predictors in 6-year-old school children - results from 5-year retrospective cohort study

    Masood Mohd

    2012-11-01

    Full Text Available Abstract Background This was a retrospective cohort study undertaken to assess the rate and pattern of dental caries development in 6-year-old school children followed-up for a period of 5 years, and to identify baseline risk factors that were associated with 5 years caries experience in Malaysian children. Methods This 5-years retrospective cohort study comprised primary school children initially aged 6 years in 2004. Caries experience of each child was recorded annually using World Health Organization criteria. The rates of dental caries were recorded in prevalence and incidence density of carious lesions from baseline to final examination. Risk assessment was done to assess relative risk for caries after 5 years in children with baseline caries status. Simple and multiple logistic regression analysis were performed to identify significant independent risk factors for caries. Results The sample consisted of 1830 school children. All components of DMFT showed significant differences between baseline and final examination. Filled teeth (FT component of the DMFT showed the greatest increases. Results revealed the initial baseline caries level in permanent dentition was a strong predictor for future caries after 5 years (RR=3.78, 95% CI=3.48-4.10, P0.001. Logistic regression analysis showed significant association between caries occurrence and residence (urban/rural (OR=1.80, Pp observed from baseline and after 5 years was 5.80 persons/100 person-year of observation. The rate of new caries-affected tooth (IDt in the period from baseline and after 5-years was 0.76 teeth/100 teeth-year of observation. Conclusion The majority of 12-year-old school children (70% were caries-free and most of the caries were concentrated in only a small proportion (30% of them. We found that the presence of caries in permanent teeth at the age of 6 years was a strong predictor of future caries development in this population. The strong evidence of early permanent teeth

  13. Observational clinical study of 22 adult-onset Pompe disease patients undergoing enzyme replacement therapy over 5years.

    Stepien, Karolina M; Hendriksz, Christian J; Roberts, Mark; Sharma, Reena

    2016-04-01

    Pompe disease is an autosomal recessive disease resulting from deficiency of the acid alpha-glucosidase (GAA). The late-onset Pompe Disease (LOPD) patients develop muscular and respiratory complications later in life. We describe a retrospective observational cohort study including 22 patients with LOPD. The cohort was assessed at baseline before Enzyme Replacement Therapy (ERT) with alglucosidase alpha (20mg/kg biweekly) was commenced and subsequently relevant information was collected at 2, 4 and 5years later. The median age of the patients at study entry was 44years (16-64years), with median disease duration of 11.5years (4-31years). At baseline, 10 patients (45%) could walk without support, 12 (55%) could walk with unilateral or bilateral support including 3/12 were wheelchair bound. Mean predicted FVC % was 55.7 (95% CI 45-66) of predicted normal at baseline and showed no significant change after 5years (54.6 (95% CI 43-66)), (all p=0.9815). Mean FVC % supine was 41.8 (95% CI 33.8-49) of predicted normal at baseline and remained significantly unchanged at 5years (48.4 (95% CI 37-59.6)), (all p=0.8680). The overnight non-invasive ventilator dependence increased by 18.2% as compared with baseline and requirement of mobility aids increased during this period by 5.2% as compared with the baseline. Mean walking distance at 6min walk test was 411.5 (95% CI 338-485) at baseline, 266.5 (95% CI 187-346) m at 2years, 238.6 (95% CI 162-315) m at 4years and 286.8 (95% CI 203-370) m at 5years (p=0.1981; ANOVA was completed only for 14 patients). A gradual decline in FVC% predicted was noted only in four cases and a decline in FVC% supine in two other. Only one patient showed a decline in both pulmonary function tests. In all remaining cases (17/22) respiratory function remains stable. In conclusion overall pulmonary function tests and mobility remained stable for 5years in majority of patients on ERT. However, in some patients they continued to decline in spite of ERT

  14. Calcification of intervertebral discs in the dachshund: a radiographic study of 115 dogs at 1 and 5 years of age

    The vertebral columns of 115 dachshunds were x-rayed at 1 and 5 years of age. This sample represented 5.7% of all dachshunds registered with the Norwegian Kennel Club in the period 1986-1988. All dogs were clinically normal at the commencement of the study. At 1 year of age calcified intervertebral discs were identified in 34 (29.6%) of the dogs and the number of calcified discs in each individual varied from 1 to 7 with a mean of 2.7. At 5 years of age calcified discs were identified in 66 (57.4%) of the dogs and the number of calcified discs in each individual varied from 1 to 11 with a mean of 3.2. Of all dogs in which calcified discs were identified at 1 year of age, 33 (97.1%) were found to have calcified discs also at 5 years of age. Of 92 calcified discs identified in the dogs at 1 year of age, 29 (31.5%) were not calcified 4 years later. Of 211 calcified discs identified in the dogs at 5 years of age, 148 (70.1%) were not calcified 4 years before. From 1 to 5 years of age, signs of spinal disease were registered in 12 (35.3%) of the dogs in which calcified discs were identified at 1 year of age, and in 7 (8.6%) of the dogs in which calcified discs were not identified at 1 year of age. Of all dogs in which one or more calcified discs had disappeared during the study-period, signs of spinal disease were registered in 9 (75.0%)

  15. Jumper's knee paradox—jumping ability is a risk factor for developing jumper's knee: A 5-year prospective study

    Visnes, Håvard; Aandahl, Hans Åge; Bahr, Roald

    2012-01-01

    Background The ‘jumper's knee paradox’, where symptomatic athletes appear to perform better in a counter movement jump (CMJ) compared to asymptomatic controls in previous case–control studies is not fully understood. Aim The aim was to examine the relationship between jumping ability and change of jumping ability as potential risk factors for developing jumper's knee. Methods A 5-year prospective cohort study among elite volleyball players, aged 16–18. Jump tests were done on a portab...

  16. Irritable bowel syndrome--prognosis and diagnostic safety. A 5-year follow-up study

    Svendsen, Jesper Hastrup; Munck, L K; Andersen, J R

    1985-01-01

    The irritable bowel syndrome is the commonest diagnosis in gastroenterological clinics, although diagnostic criteria and investigatory programs vary. To elucidate the diagnostic safety and prognosis of the syndrome, a retrospective study was conducted. One hundred and twelve consecutive patients ...

  17. Midterm survivorship and clinical outcome of INDUS knee prosthesis: 5 year followup study

    Sancheti, Kantilal H; Sancheti, Parag K; Rajeev S Joshi; Kailash R Patil; Shyam, Ashok K; Bhaskar, Raja R

    2016-01-01

    Background: INDUS knee implant has been designed as per the anatomical morphology of the Indian population and has shown good clinical outcome in short term studies. The purpose of the present study was to report the midterm survivorship and clinical outcome of this implant. Materials and Methods: Two hundred and twenty three primary total knee arthroplasties in 209 consecutive patients using the INDUS knee prosthesis were prospectively enrolled. There were 145 females (155 knees) and 64 male...

  18. Electrocution-related mortality in northern India – A 5-year retrospective study

    Sachil Kumar

    2014-03-01

    Conclusion: Death rates from electrocution among all medico-legal deaths were found to be lower in this study than in previous reports, most of them were work-related and preventable. Workers and their employers should be educated to avoid such accidents with safety measures.

  19. Treatment and rehabilitation on a stroke unit improves 5-year survival. A community-based study

    Jørgensen, H S; Kammersgaard, L P; Nakayama, H; Raaschou, H O; Larsen, K; Hübbe, P; Olsen, T S

    1999-01-01

    We have previously reported a marked reduction in mortality up to 1 year after treatment and rehabilitation on a stroke unit versus on general neurological and medical wards in unselected stroke patients. In the present study we wanted to test the hypothesis that this mortality-reducing effect is...

  20. Viral infections, prevalence and costs: A5-year, hospital based, retrospective observational study in shiraz, iran

    Many patients suffering from viral infections attend to health care centers. Data gathered from viral infections is limited to specific cases such as AIDS, viral hepatitis and Influenza. There is a significant lack of reliable documentation about other viral infections. In this study the prevalence and related costs of viral infections in hospitals of Shiraz University of Medical Sciences were reviewed. In this cross-sectional study the data were extracted from files of 1319 patients with viral infection admitted in two university hospitals during a five year period (1999-2004). The frequencies of different viral infections along with their demographic data were analyzed. The mean age of the patients was 29.24 with the range of 90 years. Hospitalization days were 8636 in 40 different wards in two hospitals. US$ 30.84 was the daily mean cost for each admitted patient. Viral meningitis was most frequent (14.2%) and 8.4% of patients died during hospitalization. This study confirms the necessity of expanding management programs for viral infections especially hepatitis B in youths in Iran. Unspecified viral infections cost much more than specified viral diseases. Viral infection costs can be reduced by finding more sensitive and specific diagnostic methods. (author)

  1. Severe idiosyncratic drug reactions with epidermal necrolysis: A 5-year study

    I O Fadeyibi

    2011-01-01

    Full Text Available Introduction: Idiosyncratic drug reactions (IDRs are unexpected responses to a drug. The spectrums of severe cutaneous reactions include Stevens-Johnson Syndrome (SJS, SJS/Lyell Syndrome and Toxic Epidermal Necrolysis (TEN. The conditions are associated with high mortality. This study was designed to determine the causal agents, patterns of presentations, review the management and make recommendations to reduce the incidence and mortality of this class of drug reactions. Materials and Methods: A retrospective study was made of patients seen with IDR in the Lagos State University Teaching Hospital, LASUTH, between January, 2004 and December, 2008. They were cases admitted with bullous skin eruptions with associated systemic symptoms. Results: Sixty-seven patients were seen, with 45 (67.2% satisfying the inclusion criteria. Fifteen males and 30 females were involved, giving a male to female (M:F ratio of 1:2. Their ages ranged from 7 to 79 years (mean, 40.02 ± 17.89 years. Peak incidences occurred among the 20-24 and 30-34 year age groups. The causal agents were antibiotics (48.89%, sulphonamides (24.44%, herbal preparations (17.78% and artemisinin drugs (8.89%. Conclusions: The age groups with the peak incidence are the most likely to indulge more in drug abuse in environments with poor drug control. Diagnosis of SJS, SJS/TEN and TEN were missed in many patients at first contact due to the progressive nature of the conditions. Patients needed reviews at regular intervals when IDR was suspected. Health education to prevent drug abuse is important and herbal preparations should be scientifically studied to determine the efficacy and side-effects.

  2. Victims' time discounting 2.5 years after the Wenchuan earthquake: an ERP study.

    Jin-Zhen Li

    Full Text Available BACKGROUND: Time discounting refers to the fact that the subjective value of a reward decreases as the delay until its occurrence increases. The present study investigated how time discounting has been affected in survivors of the magnitude-8.0 Wenchuan earthquake that occurred in China in 2008. METHODOLOGY: Nineteen earthquake survivors and 22 controls, all school teachers, participated in the study. Event-related brain potentials (ERPs for time discounting tasks involving gains and losses were acquired in both the victims and controls. FINDINGS: The behavioral data replicated our previous findings that delayed gains were discounted more steeply after a disaster. ERP results revealed that the P200 and P300 amplitudes were increased in earthquake survivors. There was a significant group (earthquake vs. non-earthquake × task (gain vs. loss interaction for the N300 amplitude, with a marginally significantly reduced N300 for gain tasks in the experimental group, which may suggest a deficiency in inhibitory control for gains among victims. CONCLUSIONS: The results suggest that post-disaster decisions might involve more emotional (System 1 and less rational thinking (System 2 in terms of a dual-process model of decision making. The implications for post-disaster intervention and management are also discussed.

  3. Outcome of in vitro fertilization in endometriosis-associated infertility: a 5-year database cohort study

    LIN Xiao-na; WEI Min-ling; TONG Xiao-mei; XU Wei-hai; ZHOU Feng; HUANG Qiong-xiao; WEN Guo-feng; ZHANG Song-ying

    2012-01-01

    Background Endometriosis affects natural fertility through various approaches,and in vitro fertilization (IVF) is a good treatment.But the IVF result of endometriosis patients is still under debate.We investigated the effect of endometriosis on IVF by analyzing the data from a single reproductive center.Methods A retrospective,database-searched cohort study was performed.Relevant information was collected from the electronic records of women who underwent IVF/intracytoplasmic sperm injection between January 2006 and December 2010 in the Assisted Reproductive Unit of Sir Run Run Shaw Hospital.Patients with endometriosis were enrolled the study group.The rest of the women formed the control group.The main outcome was the clinical pregnancy rate.Secondary outcomes were oocytes retrieved number,fertilization rate,high-quality embryo rate,number of high-quality embryo for embryo transplantation,and implantation embryo/high-quality embryo ratio (IE/HQE ratio).Comparisons were performed by the x2-test and independent t-test.Results The endometriosis group (n=177) had a markedly lower oocytes retrieved number,fertilization rate,implantation rate,and clinical pregnancy rate (7.6±5.1,63.6%,27.7%,and 45.2%,respectively) compared with the non-endometriosis group (n=4267; 11.8±7.3,68.4%,36.2%,and 55.2%,respectively).Stratified analysis showed that this difference was found in the subgroup younger than 35-years old,while only fertilization rate and implantation rate were different in the elder subgroup.The ratio of high-quality embryos transferred is lower in endometriosis group (53.7% vs.71.8%,P <0.05),but there is no difference in IE/HQE ratio between two groups.There is no significant difference in fertilization rate,implantation rate,and clinical pregnancy rate between mild and severe endometriosis patients.Conclusions Endometriosis patients suffer a decreasing IVF pregnancy rates mainly caused by reducing oocytes number and fertilization rate

  4. A RETROSPECTIVE 5 YEAR STUDY OF PPTCT PROGRAMME AT TERTIARY CARE CENTRE

    Saritha

    2015-06-01

    Full Text Available BACKGROUND: Mother to child transmission of HIV is a major cause of paediatric HIV. MTCT prevention strategies include comprehensive antenatal, postnatal and paediatric health services, voluntary counselling and testing (VCT, antiretroviral prophylaxis; counselling and support for safe infant feeding and optimal obstetrical practices. OBJECTIVES: The present retrospective study is undertaken to evaluate the effectiveness of implementation of PPTCT Programme in a tertiary care hospital. METHODOLOGY: All pregnant women attending antenatal OP and labour room were counselled and tested for HIV. All positive patients were again counselled and ART therapy started. Spouses of all positive women counselled and tested. Modification of labour and delivery practices was followed . All the babies born to positive mothers received Nevirapine prophylaxis and babies were tested at 6, 12 and 18 months. Mothers were counselled regarding breast feeding and tubectomy was advised for all patients. RESULTS: A total number of 36113 antenatal women counselled and 97.90% of them gave consent for testing. Seropositivity in these women was 0.91%. Most of these patients were primi or second gravida, majority of them were young, belonging to age group of 20 - 24 yrs. 61.84% of spouses were found to b e seropositive. Most of these women (67.72% were delivered through vaginal route. LSCS was done for obstetric indication in 32.27% of cases. Majority of mothers opted for replacement feeding (78.96%. Seropositivity of babies born to these mothers was 3.0 7%.This has shown downward trend from 2010 to 2015. CONCLUSIONS: The PPTCT programme is effective and has reduced the rate of transmission from mother to child and with present triple drug therapy a further reduction is expected.

  5. Oral health status of 5 years and 12 years old school going children in rural Gurgaon, India: An epidemiological study

    Meenu Mittal

    2014-01-01

    Full Text Available Background and Aims: Oral health is an essential component of health throughout life. Hardly any information is available on the oral health status of children in Gurgaon. Thus, the present study was conducted among 5-year-old and 12-years-old children in schools in rural Gurgaon. Materials and Methods: A total of 1003 children were examined of which 619 were in 5 years age group and 384 in 12 years group. The prevalence of dental caries was studied using dentition status and treatment needs index. For dental calculus criteria of Community Periodontal and for dental fluorosis Dean′s index was used. Results: In 5 years age group prevalence of dental caries was 68.5%, dental fluorosis was 22.5% and treatment needs were 63.7%. In 12 year age group prevalence of dental caries was 37.5%, dental fluorosis was 76.04%, highest community periodontal index score was 2, seen in 80.2% and overall treatment needs were 44.3%. Conclusion: Preventive approaches seem to be a viable alternative to tackle the overwhelming problem of dental caries and other oral diseases. Provision of oral health education in schools and school based preventive programs are important for improvement of this situation.

  6. Alveolar Ridge Contouring with Free Connective Tissue Graft at Implant Placement: A 5-Year Consecutive Clinical Study.

    Hanser, Thomas; Khoury, Fouad

    2016-01-01

    This study evaluated volume stability after alveolar ridge contouring with free connective tissue grafts at implant placement in single-tooth gaps. A total of 52 single-tooth gaps with labial volume deficiencies in the maxilla (incisors, canines, and premolars) were consecutively treated with implants and concomitant free palatal connective tissue grafts in 46 patients between 2006 and 2009. Implants had to be covered with at least 2 mm peri-implant local bone after insertion. At implant placement, a free connective tissue graft from the palate was fixed inside a labial split-thickness flap to form an existing concave buccal alveolar ridge contour due to tissue volume deficiency into a convex shape. Standardized volumetric measurements of the labial alveolar contour using a template were evaluated before connective tissue grafting and at 2 weeks, 1 year, and 5 years after implantprosthetic incorporation. Tissue volume had increased significantly (P .05) kept their volume from baseline to 1 year after prosthetic incorporation and from baseline to 5 years after prosthetic incorporation, respectively, whereas reference points located within the area of the implant sulcus showed a significant (P < .05) decrease in volume. Clinically, 5 years after prosthetic incorporation the originally concave buccal alveolar contour was still convex in all implants, leading to a continuous favorable anatomical shape and improved esthetic situation. Intraoral radiographs confirmed osseointegration and stable peri-implant parameters with a survival rate of 100% after a follow-up of approximately 5 years. Implant placement with concomitant free connective tissue grafting appears to be an appropriate long-term means to contour preexisting buccal alveolar volume deficiencies in single implants. PMID:27333003

  7. The Importance of Longitudinal Studies

    Knezek, Patricia

    2014-01-01

    It has been eight years since the AAS Council unanimously endorsed the document, known as "Equity Now: The Pasadena Recommendations for Gender Equality in Astronomy," in January 2005. This document was the main product of the conference entitled “Women in Astronomy II: Ten Years After” (WIA II), held in June 2003 in Pasadena, CA. One of the key recommendations represented in that document was the need for a longitudinal study of astronomers. It was recognized that in order to understand our own field, how it is evolving, and the impact on individuals, we need to track people over time. I will discuss the fundamental questions that led to the recommendation, and set the stage for the current (ongoing) longitudinal study.

  8. Parenting style, the home environment, and screen time of 5-year-old children; the 'be active, eat right' study.

    Lydian Veldhuis

    Full Text Available INTRODUCTION: The global increase in childhood overweight and obesity has been ascribed partly to increases in children's screen time. Parents have a large influence on their children's screen time. Studies investigating parenting and early childhood screen time are limited. In this study, we investigated associations of parenting style and the social and physical home environment on watching TV and using computers or game consoles among 5-year-old children. METHODS: This study uses baseline data concerning 5-year-old children (n = 3067 collected for the 'Be active, eat right' study. RESULTS: Children of parents with a higher score on the parenting style dimension involvement, were more likely to spend >30 min/day on computers or game consoles. Overall, families with an authoritative or authoritarian parenting style had lower percentages of children's screen time compared to families with an indulgent or neglectful style, but no significant difference in OR was found. In families with rules about screen time, children were less likely to watch TV>2 hrs/day and more likely to spend >30 min/day on computers or game consoles. The number of TVs and computers or game consoles in the household was positively associated with screen time, and children with a TV or computer or game console in their bedroom were more likely to watch TV>2 hrs/day or spend >30 min/day on computers or game consoles. CONCLUSION: The magnitude of the association between parenting style and screen time of 5-year-olds was found to be relatively modest. The associations found between the social and physical environment and children's screen time are independent of parenting style. Interventions to reduce children's screen time might be most effective when they support parents specifically with introducing family rules related to screen time and prevent the presence of a TV or computer or game console in the child's room.

  9. A Comparative Study on Motor Skills in 5-Year-Old Children with Phonological and Phonetic Disorders

    Fatemeh Hasanati

    2011-06-01

    Full Text Available Background and Aim: Speech as a motor phenomenon requires repetitive and rapid function of articulatory organs performing extremely fine movements. Practice on motor skills results in facilitation in treatment progress of children with phonological disorders. The purpose of this study was to compare motor skills in 5-year-old children with phonological and phonetic disorders.Methods: Thirty-two children age 5 years, 16 with phonemical speech sound disorders and 16 with difficulty at a phonetic level participated in this study. TOLD Test was performed for linguistic skills investigation among children. Phonetic test, Wepman test, diadochokinesis and oral assessment was used for diagnosis between phonological and phonetic disorders. The children were also evaluated with Oseretsky motor developmental scale .Results: In comparison, mean scores of movement skills between both groups showed significant difference (p=0.006 and children with phonetic disorder got significantly higher scores on all part of this test.Conclusions: The findings of this study support the idea that speech sound disorders are frequently associated with motor problems, and that type of articulation disorder affects the motor performance in a different way. Phonological disorders seem to have more impact on motor performance than phonetic disorders. The results authenticate the need to pay more attention to the motor skills of children with articulation disorders.

  10. Outcomes and indications for intervention in non-operative management of paediatric liver trauma: A 5 year retrospective study

    Aim: To determine the applicability of accurate computed tomography (CT) evaluation and embolization as non-operative management for liver trauma in a paediatric population. Material and methods: A retrospective observational study of 37 children (mean age 10.5 years) with hepatic trauma (28 blunt, 9 penetrating) admitted to a trauma referral centre over a 5 year period. All patients were evaluated with CT and scored with an Association for the Surgery of Trauma score. Inpatient information was reviewed for demographics, associated injuries, modes of management, efficacy and complications of management, and outcome. Statistical analysis was performed. Results: There were seven contusions, two grade I, two grade II, nine grade III, and 17 grade IV liver lacerations. Only two patients (grade IV, penetrating) underwent surgery for the management of bowel perforation. All children had non-surgical treatment of their liver trauma: three cases (grade IV) had primary angiography due to CT evidence of active bleeding and embolization was performed in two of these. Seven patients (two grade III, five grade IV) had angiography during the follow-up for evidence of a complicating pseudoaneurysm and embolization was performed in six of them. Embolization was successful in all the children; one minor complication occurred (cholecystitis). Endoscopic retrograde cholangiopancreatography (ERCP) plus stenting was performed in two cases for a bile leak. All 37 children had a positive outcome. Conclusion: The present study demonstrates that non-operative management of hepatic trauma is applicable to children and may have a higher success rate than in adults

  11. Developmental neuropsychological assessment of 4- to 5-year-old children born following Preimplantation Genetic Diagnosis (PGD): A pilot study.

    Sacks, Gilat Chaya; Altarescu, Gheona; Guedalia, Judith; Varshaver, Irit; Gilboa, Tal; Levy-Lahad, Ephrat; Eldar-Geva, Talia

    2016-01-01

    The purpose of this pilot study was to evaluate developmental neuropsychological profiles of 4- to 5-year-old children born after Preimplantation Genetic Diagnosis (PGD). Twenty-seven participants received a neurological examination and a battery of neuropsychological assessments including Wechsler Preschool & Primary Scale of Intelligence - Third Edition (WPPSI-III; cognitive development), Preschool Language Scale, Fourth Edition (PLS-4; language development), Wide Range Assessment of Visual Motor Abilities (visual motor abilities), Childhood Autism Rating Scales II (a screening test for autistic spectrum disorders), and the Miles ABC Test (ocular dominance). Parental questionnaires included the Behavior Rating Inventory of Executive Function Preschool Version (BRIEF-P; executive function), Child Behavior Checklist (CBCL) and the Carey Temperament Scales Behavioral Style Questionnaire (socioemotional development and temperament), and the Vineland Adaptive Behavior Scales, Interview Edition, Second Edition (general adaptive behavior). Subjects' tests results were compared to each test's norms. Children born after PGD demonstrated scores within the normal or above-normal ranges for all developmental outcomes (mean ± SD): WPPSI-III-VIQ 107.4 ± 14.4 (p = .013), PLS-4-Total 113.2 ± 12.4, p children had a significant difference between their VIQ and PIQ scores (compared to 27% in the general population). One subject was found to show possible signs of autistic spectrum disorder, although a family history of autism was noted. In conclusion, in this pilot study, children assessed at age 4-5 years and conceived after PGD displayed developmental neuropsychological outcomes within normal limits as compared to their chronologic peers. A larger study is needed to evaluate and follow the neuropsychological development of children born after PGD. PMID:25774437

  12. Job stress and the use of antidepressant medicine: a 3.5-year follow-up study among Danish employees

    Thielen, Karsten; Nygaard, Else; Rugulies, Reiner;

    2011-01-01

    ABSTRACT Objectives To investigate if exposure to adverse psychological job characteristics predicts incident use of antidepressants, taking into account differential misclassification and residual confounding. Methods A prospective cohort study with a 3.5-year follow-up of 4661 Danish employees...... high demands was found for high anticipated private social support and living with children. Among women, no effect of job characteristics on antidepressant use was found. Conclusion Among men, but not among women, high quantitative demands and low social support from colleagues were predictive of...... incident use of antidepressants, indicating incident depressive episodes, even after taking into account differential misclassification and residual confounding. The effects were buffered for those with high anticipated private social support and for those having children....

  13. Implant-supported overdentures, a prevention of bone loss in edentulous mandibles? A 5-year follow-up study

    von Wowern, N; Gotfredsen, K

    2001-01-01

    minimizes the physiologic age-related mandibular BMC loss, 2) this effect seems to be independent of attachment system and 3) mandibular osteoporosis prior to implant treatment may be a risk factor for bone loss around implants. However, this treatment can be recommended also in osteoporotic persons.......The purpose of this study were to analyse 1) the changes in the bone mineral content (BMC) in mandibles with implant-supported overdentures when compared with the physiologic age-related mandibular BMC loss, 2) whether the BMC changes were different in groups without or with a bar connecting the...... in half of the patients. BMC measurements were performed in vivo by dual-photon scanner at baseline, just after attachment insertion, at 2-year and 5-year visits. Mandibular osteoporosis was estimated by comparing baseline BMC values with normal mandibular BMC values for young adults of same gender...

  14. Congenital cystic lesions of lung in the paediatric population: A 5-year single institutional study with review of literature

    Shibsankar Barman

    2015-01-01

    Full Text Available Background: The aim was to evaluate the clinical presentation, investigation modalities, operative management, pathology, outcome (morbidity and mortality and short term follow-up of congenital cystic lesions of the lung. Materials and Methods: This is a retrospective study. Study period was 5 years (December 2008-November 2013 in the Department of paediatric surgery, Nil Ratan Sircar Medical College. Study population: Total number = 10 patients. Age range: 2 days-7 years. (Neonate-4. Male and female ratio = 1:1. Result: Among 10 cases of lung cyst four having congenital lobar emphysema, four having congenital pulmonary airway malformation, one sequestration and one teratoma. All patients have undergone surgical excision in terms of lobectomy or excision of the lesion. Post-operative histopathology confirmed the diagnosis. Recovery was uneventful. Conclusion: Although our experience is limited, operative management of lung cysts seems to be safe with rewarding results. However we are yet to encounter many of the other varieties of the cysts found in the lung, which may be associated with other congenital anomalies and have an impact on prognosis.

  15. Valvular Abnormalities Detected by Echocardiography in 5-Year Survivors of Childhood Cancer: A Long-Term Follow-Up Study

    Purpose: To determine the prevalence of valvular abnormalities after radiation therapy involving the heart region and/or treatment with anthracyclines and to identify associated risk factors in a large cohort of 5-year childhood cancer survivors (CCS). Methods and Materials: The study cohort consisted of all 626 eligible 5-year CCS diagnosed with childhood cancer in the Emma Children's Hospital/Academic Medical Center between 1966 and 1996 and treated with radiation therapy involving the heart region and/or anthracyclines. We determined the presence of valvular abnormalities according to echocardiograms. Physical radiation dose was converted into the equivalent dose in 2-Gy fractions (EQD2). Using multivariable logistic regression analyses, we examined the associations between cancer treatment and valvular abnormalities. Results: We identified 225 mainly mild echocardiographic valvular abnormalities in 169 of 545 CCS (31%) with a cardiac assessment (median follow-up time, 14.9 years [range, 5.1-36.8 years]; median attained age 22.0 years [range, 7.0-49.7 years]). Twenty-four CCS (4.4%) had 31 moderate or higher-graded abnormalities. Most common abnormalities were tricuspid valve disorders (n=119; 21.8%) and mitral valve disorders (n=73; 13.4%). The risk of valvular abnormalities was associated with increasing radiation dose (using EQD2) involving the heart region (odds ratio 1.33 per 10 Gy) and the presence of congenital heart disease (odds ratio 3.43). We found no statistically significant evidence that anthracyclines increase the risk. Conclusions: Almost one-third of CCS treated with potentially cardiotoxic therapy had 1 or more asymptomatic, mostly mild valvular abnormalities after a median follow-up of nearly 15 years. The most important risk factors are higher EQD2 to the heart region and congenital heart disease. Studies with longer follow-up are necessary to investigate the clinical course of asymptomatic valvular abnormalities in CCS

  16. Valvular Abnormalities Detected by Echocardiography in 5-Year Survivors of Childhood Cancer: A Long-Term Follow-Up Study

    Pal, Helena J. van der, E-mail: h.j.vanderpal@amc.uva.nl [Department of Medical Oncology, Emma Children' s Hospital/Academic Medical Center, Amsterdam (Netherlands); Department of Pediatric Oncology, Emma Children' s Hospital/Academic Medical Center, Amsterdam (Netherlands); Dijk, Irma W. van [Department of Radiation Oncology, Emma Children' s Hospital/Academic Medical Center, Amsterdam (Netherlands); Geskus, Ronald B. [Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Emma Children' s Hospital/Academic Medical Center, Amsterdam (Netherlands); Kok, Wouter E. [Department of Cardiology, Emma Children' s Hospital/Academic Medical Center, Amsterdam (Netherlands); Koolen, Marianne; Sieswerda, Elske [Department of Pediatric Oncology, Emma Children' s Hospital/Academic Medical Center, Amsterdam (Netherlands); Oldenburger, Foppe; Koning, Caro C. [Department of Radiation Oncology, Emma Children' s Hospital/Academic Medical Center, Amsterdam (Netherlands); Leeuwen, Flora E. van [Department of Epidemiology, Netherlands Cancer Institute, Amsterdam (Netherlands); Caron, Huib N.; Kremer, Leontien C.; Dalen, Elvira C. van [Department of Pediatric Oncology, Emma Children' s Hospital/Academic Medical Center, Amsterdam (Netherlands)

    2015-01-01

    Purpose: To determine the prevalence of valvular abnormalities after radiation therapy involving the heart region and/or treatment with anthracyclines and to identify associated risk factors in a large cohort of 5-year childhood cancer survivors (CCS). Methods and Materials: The study cohort consisted of all 626 eligible 5-year CCS diagnosed with childhood cancer in the Emma Children's Hospital/Academic Medical Center between 1966 and 1996 and treated with radiation therapy involving the heart region and/or anthracyclines. We determined the presence of valvular abnormalities according to echocardiograms. Physical radiation dose was converted into the equivalent dose in 2-Gy fractions (EQD{sub 2}). Using multivariable logistic regression analyses, we examined the associations between cancer treatment and valvular abnormalities. Results: We identified 225 mainly mild echocardiographic valvular abnormalities in 169 of 545 CCS (31%) with a cardiac assessment (median follow-up time, 14.9 years [range, 5.1-36.8 years]; median attained age 22.0 years [range, 7.0-49.7 years]). Twenty-four CCS (4.4%) had 31 moderate or higher-graded abnormalities. Most common abnormalities were tricuspid valve disorders (n=119; 21.8%) and mitral valve disorders (n=73; 13.4%). The risk of valvular abnormalities was associated with increasing radiation dose (using EQD{sub 2}) involving the heart region (odds ratio 1.33 per 10 Gy) and the presence of congenital heart disease (odds ratio 3.43). We found no statistically significant evidence that anthracyclines increase the risk. Conclusions: Almost one-third of CCS treated with potentially cardiotoxic therapy had 1 or more asymptomatic, mostly mild valvular abnormalities after a median follow-up of nearly 15 years. The most important risk factors are higher EQD{sub 2} to the heart region and congenital heart disease. Studies with longer follow-up are necessary to investigate the clinical course of asymptomatic valvular abnormalities

  17. Musculoskeletal extremity injuries in a cohort of schoolchildren aged 6-12: a 2.5-year prospective study.

    Jespersen, E; Rexen, C T; Franz, C; Møller, N C; Froberg, K; Wedderkopp, N

    2015-04-01

    The objectives of this prospective school cohort study were to describe the epidemiology of diagnosed musculoskeletal extremity injuries and to estimate the injury incidence rates in relation to different settings, different body regions and injury types. In all, 1259 schoolchildren, aged 6-12, were surveyed weekly during 2.5 years using a new method of automated mobile phone text messaging asking questions on the presence of any musculoskeletal problems. All injuries were clinically diagnosed. Physical activity was measured from text messaging and accelerometers. A total number of 1229 injuries were diagnosed; 180 injuries in the upper extremity and 1049 in the lower extremity, with an overall rate of 1.59 injuries per 1000 physical activity units [95% confidence interval (CI) 1.50-1.68]. Upper extremities accounted for a rate of 0.23 (95% CI 0.20-0.27) and lower extremities accounted for 1.36 (95% CI 1.27-1.44). This study has added a wide overall perspective to the area concerning incidence and incidence rates of musculoskeletal extremity injuries in schoolchildren aged 6-12 years, including severe and less severe, traumatic, and overuse injuries. The understanding of injury epidemiology in children is fundamental to the acknowledgement and insurance of the appropriate prevention and treatment. PMID:24472003

  18. Cancer-Related Fatigue in Women With Breast Cancer: Outcomes of a 5-Year Prospective Cohort Study.

    Goldstein, David

    2012-04-16

    PURPOSEProlonged and disabling fatigue is prevalent after cancer treatment, but the early natural history of cancer-related fatigue (CRF) has not been systematically examined to document consistent presence of symptoms. Hence, relationships to cancer, surgery, and adjuvant therapy are unclear. PATIENTS AND METHODSA prospective cohort study of women receiving adjuvant treatment for early-stage breast cancer was conducted. Women (n = 218) were enrolled after surgery and observed at end treatment and at 1, 3, 6, 9, and 12 months as well as 5 years. Structured interviews and self-report questionnaires were used to record physical and psychologic health as well as disability and health care utilization. Patients with CRF persisting for 6 months were assessed to exclude alternative medical and psychiatric causes of fatigue. Predictors of persistent fatigue, mood disturbance, and health care utilization were sought by logistic regression.ResultsThe case rate for CRF was 24% (n = 51) postsurgery and 31% (n = 69) at end of treatment; it became persistent in 11% (n = 24) at 6 months and 6% (n = 12) at 12 months. At each time point, approximately one third of the patients had comorbid mood disturbance. Persistent CRF was predicted by tumor size but not demographic, psychologic, surgical, or hematologic parameters. CRF was associated with significant disability and health care utilization. CONCLUSIONCRF is common but generally runs a self-limiting course. Much of the previously reported high rates of persistent CRF may be attributable to factors unrelated to the cancer or its treatment.

  19. A unique trend of murder-suicide in the Jamnagar region of Gujarat, India (a retrospective study of 5 years).

    Gupta, B D; Gambhir Singh, O

    2008-05-01

    Jamnagar region, Gujarat state, enjoys a relatively low incidence of homicide in India. In the 5 year period from 2000 to 2004, 8 mothers committed 13 murders involving 3 male and 10 female victims and in every case it was followed by suicide of the assailant mothers. During the study the annual incidence of murder-suicide was about 1.8 cases. All the assailants were mothers and the victims were their small children in the age group of 6 months to 7 years. Five incidents took place in rural areas and three in urban areas. It was prevalent only in low socio-economic families. Methods both for killing and suicide were either burning or drowning. All the mothers were legally married and living with the family. Family and family related matters were the main motives for killing. In one case there was history of depression of the mother due to her previous miscarriage. Alcohol consumption or drug abuse was not seen even in a single case. All cases fell in the altruistic category of filicide-suicide. PMID:18423359

  20. Back injuries in a cohort of schoolchildren aged 6-12: A 2.5-year prospective study.

    Franz, C; Jespersen, E; Rexen, C T; Leboeuf-Yde, C; Wedderkopp, N

    2016-08-01

    The aims of this prospective school cohort study were to describe the epidemiology of diagnosed back pain in childhood, classified as either nontraumatic or traumatic back injury, and to estimate the association with physical activity in different settings. Over 2.5 years, 1240 children aged 6-12 years were surveyed weekly using mobile text messages to ask about the presence or absence of back pain. Pain was clinically diagnosed and injuries were classified using the International Classification of Diseases version 10. Physical activity data were obtained from text messages and accelerometers. Of the 315 back injuries diagnosed, 186 injuries were nontraumatic and 129 were traumatic. The incidence rate ratio was 1.5 for a nontraumatic back injury compared with a traumatic injury. The overall estimated back injury incidence rate was 0.20 per 1000 physical activity units (95% confidence interval 0.18-0.23). The back injury incidence rates were higher for sports when exposure per 1000 physical activity units was taken into consideration and especially children horse-riding had a 40 times higher risk of sustaining a traumatic back injury compared to the risk during non-organized leisure time physical activity. However, the reasonably low injury incidence rates support the recommendations of children continuously being physically active. PMID:26130046

  1. Long-term Efficacy of Subthalamic Nucleus Deep Brain Stimulation in Parkinson′s Disease: A 5-year Follow-up Study in China

    Lu-Lu Jiang

    2015-01-01

    Conclusions: STN DBS is an effective intervention for PD, although associated with a slightly diminished efficacy after 5 years. Compared with other studies, patients in our study required lower voltage and medication for satisfactory symptom control.

  2. Prognosis of HIV-1-infected patients up to 5 years after initiation of HAART: collaborative analysis of prospective studies

    May, M; Sterne, JAC; Sabin, C;

    2007-01-01

    OBJECTIVE: To estimate the prognosis over 5 years of HIV-1-infected, treatment-naive patients starting HAART, taking into account the immunological and virological response to therapy. DESIGN: A collaborative analysis of data from 12 cohorts in Europe and North America on 20,379 adults who started...... HAART between 1995 and 2003. METHODS: Parametric survival models were used to predict the cumulative incidence at 5 years of a new AIDS-defining event or death, and death alone, first from the start of HAART and second from 6 months after the start of HAART. Data were analysed by intention...

  3. Risk for high depressive symptoms in diagnosed and previously undetected diabetes: 5-year follow-up results of the Heinz Nixdorf Recall study.

    Andrea Icks

    Full Text Available OBJECTIVE: The objective of this study was to determine the risk for the development of high depressive symptoms in study participants with diagnosed and previously undetected diabetes mellitus compared to those without diabetes in a prospective population-based cohort study in Germany. METHODS: We estimated the 5-year cumulative incidence of high depressive symptoms in participants without high depressive symptoms at baseline (n = 3,633, 51.4% men, mean age (SD 59.1 (7.6 years, 7.0% diagnosed diabetes, 5.3% previously undetected diabetes from the population-based Heinz Nixdorf Recall study. Diabetes was assessed by self-report, medication, and blood glucose. High depressive symptoms were assessed using CES-D. We calculated odds ratios and their corresponding 95% confidence interval, using multiple logistic regression analyses. RESULT: Cumulative 5-year incidences (95% CI of high depressive symptoms in participants with diagnosed, undetected, and without diabetes were 7.1 (4.2-10.9, 4.1 (1.8-8.0, and 6.5 (5.6-7.4, respectively. The age-sex-adjusted OR for developing high depressive symptoms was 1.22 (0.74-2.03 in participants with diagnosed compared to those without diabetes, and 1.00 (0.59-1.68 after adjustment for BMI, physical activity, education, stroke, and myocardial infarction. The age-sex adjusted OR for developing high depressive symptoms in participants with previously undetected diabetes compared to those without diabetes was 0.72; 0.35-1.48; and fully adjusted 0.62; 0.30-1.30. CONCLUSION: We found no significant associations, maybe due to low power. However, our results are in line with a recent meta-analysis suggesting that risk of developing high depressive symptoms in patients with diagnosed diabetes may be moderately higher than in those without diabetes, and that comorbidity may explain in part this association. In participants with previously undetected diabetes, this first longitudinal study indicates that the risk is not

  4. Characteristics of highly impaired children with severe chronic pain: a 5-year retrospective study on 2249 pediatric pain patients

    Zernikow Boris

    2012-05-01

    Full Text Available Abstract Background Prevalence of pain as a recurrent symptom in children is known to be high, but little is known about children with high impairment from chronic pain seeking specialized treatment. The purpose of this study was the precise description of children with high impairment from chronic pain referred to the German Paediatric Pain Centre over a 5-year period. Methods Demographic variables, pain characteristics and psychometric measures were assessed at the first evaluation. Subgroup analysis for sex, age and pain location was conducted and multivariate logistic regression applied to identify parameters associated with extremely high impairment. Results The retrospective study consisted of 2249 children assessed at the first evaluation. Tension type headache (48%, migraine (43% and functional abdominal pain (11% were the most common diagnoses with a high rate of co-occurrence; 18% had some form of musculoskeletal pain disease. Irrespective of pain location, chronic pain disorder with somatic and psychological factors was diagnosed frequently (43%. 55% of the children suffered from more than one distinct pain diagnosis. Clinically significant depression and general anxiety scores were expressed by 24% and 19% of the patients, respectively. Girls over the age of 13 were more likely to seek tertiary treatment compared to boys. Nearly half of children suffered from daily or constant pain with a mean pain value of 6/10. Extremely high pain-related impairment, operationalized as a comprehensive measure of pain duration, frequency, intensity, pain-related school absence and disability, was associated with older age, multiple locations of pain, increased depression and prior hospital stays. 43% of the children taking analgesics had no indication for pharmacological treatment. Conclusion Children with chronic pain are a diagnostic and therapeutic challenge as they often have two or more different pain diagnoses, are prone to misuse of

  5. Environmental exposure of lead and iron deficit anemia in children age ranged 1-5 years: A cross sectional study

    Iron (Fe) deficiency is the most common nutritional problem among children and lead (Pb) toxicity is the most common environmental health threat to children all over the world. The objective of this study was to determine blood lead (BPb) levels and prevalence of Fe deficient anemia among 1 to 5 year old children attending day care clinic in pediatric ward of civil hospital Karachi, Pakistan. A total of 340 children of both genders participating in this study, were screened for anemia. Among them 215 were anemic and 125 non-anemic. The anemic group was further divided in two groups on the basis of % hemoglobin (Hb), mild (Hb 10 g/dL). The blood samples were analysed for Pb and Fe, along with hematological parameters. The result indicated that anemic children had a higher mean values of Pb in blood than referent children with Hb > 10 g/dL. The Pb levels 10 μg/dL. The BPb concentration in severe anemic children (53%) was found in the range of 100-200 μg/L, whereas 47% had > 200 μg/L. The significant negative correlations of BPb level with % Hb (r = -0.514 and r = -0.685) and Fe contents (r = -0.522, r = -0.762, p < 0.001) were observed in mild and severe anemic children respectively. While positive correlation was observed between BPb and age of both group and genders (r = 0.69, p < 0.01). The BPb levels were significantly associated with biochemical indices in the blood which have the potential to be used as biomarkers of Pb intoxication and Fe deficient anemia.

  6. Environmental exposure of lead and iron deficit anemia in children age ranged 1-5 years: A cross sectional study

    Shah, Faheem; Kazi, Tasneem Gul; Afridi, Hassan Imran; Baig, Jameel Ahmed; Khan, Sumaira, E-mail: skhanzai@gmail.com; Kolachi, Nida Fatima; Wadhwa, Sham Kumar; Shah, Abdul Qadir, E-mail: shah_ceac@yahoo.com, E-mail: tgkazi@yahoo.com, E-mail: hassanimranafridi@yahoo.com, E-mail: jab_mughal@yahoo.com, E-mail: nidafatima6@gmail.com [National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080 (Pakistan)

    2010-10-15

    Iron (Fe) deficiency is the most common nutritional problem among children and lead (Pb) toxicity is the most common environmental health threat to children all over the world. The objective of this study was to determine blood lead (BPb) levels and prevalence of Fe deficient anemia among 1 to 5 year old children attending day care clinic in pediatric ward of civil hospital Karachi, Pakistan. A total of 340 children of both genders participating in this study, were screened for anemia. Among them 215 were anemic and 125 non-anemic. The anemic group was further divided in two groups on the basis of % hemoglobin (Hb), mild (Hb < 10 g/dL) and severe anemic group (Hb < 8 g/dL), while non-anemic as referent children (Hb > 10 g/dL). The blood samples were analysed for Pb and Fe, along with hematological parameters. The result indicated that anemic children had a higher mean values of Pb in blood than referent children with Hb > 10 g/dL. The Pb levels < 100 {mu}g/L were detected in 40% referent children while 60% of them had > 10 {mu}g/dL. The BPb concentration in severe anemic children (53%) was found in the range of 100-200 {mu}g/L, whereas 47% had > 200 {mu}g/L. The significant negative correlations of BPb level with % Hb (r = -0.514 and r = -0.685) and Fe contents (r = -0.522, r = -0.762, p < 0.001) were observed in mild and severe anemic children respectively. While positive correlation was observed between BPb and age of both group and genders (r = 0.69, p < 0.01). The BPb levels were significantly associated with biochemical indices in the blood which have the potential to be used as biomarkers of Pb intoxication and Fe deficient anemia.

  7. Advanced life support provider course in Italy: A 5-year nationwide study to identify the determinants of course success

    F. Semeraro; A. Scapigliati; G. Tammaro; U. Olcese; E.L. Cerchiari; G. Ristagno

    2015-01-01

    INTRODUCTION: The advanced life support (ALS) provider course is the gold standard for teaching and assessing competence in advanced resuscitation. Outcomes over a 5-year period of European Resuscitation (ERC)/IRC ALS provider courses in Italy were investigated, and the factors associated with cours

  8. Morbidity and mortality in the antiphospholipid syndrome during a 5-year period: a multicentre prospective study of 1000 patients

    Cervera, R; Khamashta, M A; Shoenfeld, Y; Camps, M T; Jacobsen, S; Kiss, E; Zeher, M M; Tincani, A; Kontopoulou-Griva, I; Galeazzi, M; Bellisai, F; Meroni, P L; Derksen, R H W M; de Groot, P G; Gromnica-Ihle, E; Baleva, M; Mosca, M; Bombardieri, S; Houssiau, F; Gris, J-C; Quéré, I; Hachulla, E; Vasconcelos, C; Roch, B; Fernández-Nebro, A; Piette, J-C; Espinosa, G; Bucciarelli, S; Pisoni, C N; Bertolaccini, M L; Boffa, M-C; Hughes, G R V

    2008-01-01

    OBJECTIVES: To identify the main causes of morbidity and mortality in patients with antiphospholipid syndrome (APS) during a 5-year period and to determine clinical and immunological parameters with prognostic significance. METHODS: The clinical and immunological features of a cohort of 1000...

  9. Fears in Czech Adolescents: A Longitudinal Study

    Michalcáková, Radka; Lacinová, Lenka; Kyjonková, Hana; Bouša, Ondrej; Jelínek, Martin

    2013-01-01

    The present study investigates developmental patterns of fear in adolescence. It is based on longitudinal data collected as a part of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) project. A total of 186 Czech adolescents (43% girls) were assessed repeatedly at the age of 11, 13, and 15 years. The free-response method was…

  10. Optic neuritis: a 5-year follow-up study of Chinese patients based on aquaporin-4 antibody status and ages.

    Zhou, Huanfen; Zhao, Shuo; Yin, Dongfang; Chen, Xiaofei; Xu, Quangang; Chen, Tingjun; Li, Xiaoyan; Wang, Junqing; Li, Hongyang; Peng, Chunxia; Lin, Dahe; Wei, Shihui

    2016-07-01

    Little work has been performed on the long-term outcome of optic neuritis (ON) according to the status of aquaporin-4 antibody (AQP4-Ab) and long-term prognosis in older patients in China. This study retrospectively analyzed medical records in a cohort of Chinese patients with 5-year follow-up according to AQP4-Ab status and ages from January 2009 to December 2010. The clinical features, laboratory findings and risk factors for prognosis were analyzed. A total of 128 ON patients were included, 66.4 % of whom were female. The median age at onset was 36.8 years (range 18-73). Serum AQP4-Ab was positive in 45 (35.2 %) patients, with greater frequency in the female, bilateral, and recurrent ON groups (48.2, 42.5 and 53.6 %, respectively). Seropositive AQP4-Ab ON patients had worse visual recovery compared to seronegative patients (p = 0.033). The average and four quadrants of retinal nerve fiber layer (RNFL) thickness were significantly thinner in the seropositive group than in the seronegative group (p transverse myelitis (TM) episode were ocular pain and recurrence within 1 year. The older patients had worse visual outcome after the first episode of ON than the younger patients (p = 0.007). However, the two groups did not differ significantly with regard to prevalence of AQP4-Ab, long-term visual recovery and the risk of developing to NMO/MS. PMID:27159992

  11. The Study of Risk Factors of Malnutrition in Children under 5 Years Attending to Health Centers in Zahedan City

    F. Montazerifar

    2003-07-01

    Full Text Available Malnutrition is one of the most important factors of prevalence of diseases and mortality in children. On the other hand , identification of causative agents of malnutrition and prevention and control of disease is very crucial . This study was done for evaluation of risk factors in malnourished children under 5 years old in Zahedan. For this purpose , 1050 children attending to health centers of Zahedan who had malnutrition selected randomly in a descriptive cross sectional study and a questionnaire with demographic characteristics of mothers and children completed by interviewing. Then , collected data was analyzed by SPSS software and descriptive statistics. Results of the study showed that malnutrition in girls was more prevalent than boys (60.1% and 39.9% respectively. Also it was cleared that malnutrition in 6–24 months children was more prevalent than other age groups. In majority of cases interval of consecutive pregnancies was less than 24 month(35.2% and number of family members was more than 5 persons (47%. In 54.3% of children the age of beginning food supplement was after 6 month. Most of the parents were uneducated (38.5% fathers and 52.0% mothers. Although 97.1% of mothers were house-wives but 51.9% of them were house-wives and uneducated . In 69% , weight gain of mothers during pregnancy was less than 7 Kg total studied cases 58.4% of mothers had attended to health centers during pregnancy but in 65.9% , the number of attending during this period was less than 4 times. From above results it was concluded that malnutrition in children is more due to defect in preparation procedure and using food supplement and the time of beginning food supplement , illiteracy and low education of mother and lack of family planning. So, training mothers for increasing their knowledge making more efforts for changing culture view point of people for family planning , keeping enough proper interval in pregnancies , equal oportunity for boys and

  12. A Clinical Algorithm to Identify HIV Patients at High Risk for Incident Active Tuberculosis: A Prospective 5-Year Cohort Study.

    Susan Shin-Jung Lee

    Full Text Available Predicting the risk of tuberculosis (TB in people living with HIV (PLHIV using a single test is currently not possible. We aimed to develop and validate a clinical algorithm, using baseline CD4 cell counts, HIV viral load (pVL, and interferon-gamma release assay (IGRA, to identify PLHIV who are at high risk for incident active TB in low-to-moderate TB burden settings where highly active antiretroviral therapy (HAART is routinely provided.A prospective, 5-year, cohort study of adult PLHIV was conducted from 2006 to 2012 in two hospitals in Taiwan. HAART was initiated based on contemporary guidelines (CD4 count < = 350/μL. Cox regression was used to identify the predictors of active TB and to construct the algorithm. The validation cohorts included 1455 HIV-infected individuals from previous published studies. Area under the receiver operating characteristic (ROC curve was calculated.Seventeen of 772 participants developed active TB during a median follow-up period of 5.21 years. Baseline CD4 < 350/μL or pVL ≥ 100,000/mL was a predictor of active TB (adjusted HR 4.87, 95% CI 1.49-15.90, P = 0.009. A positive baseline IGRA predicted TB in patients with baseline CD4 ≥ 350/μL and pVL < 100,000/mL (adjusted HR 6.09, 95% CI 1.52-24.40, P = 0.01. Compared with an IGRA-alone strategy, the algorithm improved the sensitivity from 37.5% to 76.5%, the negative predictive value from 98.5% to 99.2%. Compared with an untargeted strategy, the algorithm spared 468 (60.6% from unnecessary TB preventive treatment. Area under the ROC curve was 0.692 (95% CI: 0.587-0.798 for the study cohort and 0.792 (95% CI: 0.776-0.808 and 0.766 in the 2 validation cohorts.A validated algorithm incorporating the baseline CD4 cell count, HIV viral load, and IGRA status can be used to guide targeted TB preventive treatment in PLHIV in low-to-moderate TB burden settings where HAART is routinely provided to all PLHIV. The implementation of this algorithm will avoid unnecessary

  13. A Cross-sectional Study for Determinations of Prevention Behaviors of Domestic Accidents in Mothers with Children Less than 5- year

    Farbod Ebadi Fardazar; Kamyar Mansori; Mahnaz Solhi; Syyedeh Shahrbanou Hashemi; Erfan Ayubi; Fatemeh Khosravi Shadmani; Salman Khazaei; Shiva Mansouri hanis

    2016-01-01

    Background: Accidents are the first cause of death in children under 5- year, especially in low- and middle-income countries. The aim of this study was to identify the determinants of prevention behavior of domestic accidents in mothers of children fewer than 5 years old based on protection motivation theory )PMT(. Materials and Methods: In this cross-sectional descriptive-analytic study, 190 mothers were randomly selected. The data collection tool was researcher made questionnaire about prev...

  14. Association of Diabetes in Pregnancy with Child Weight at Birth, Age 12 Months and 5 Years – A Population-Based Electronic Cohort Study

    Morgan, Kelly; Rahman, Mohammed; Atkinson, Mark; Zhou, Shang-Ming; Hill, Rebecca; Khanom, Ashrafunnesa; Paranjothy, Shantini; Brophy, Sinead

    2013-01-01

    Background This study examines the effect of diabetes in pregnancy on offspring weight at birth and ages 1 and 5 years. Methods A population-based electronic cohort study using routinely collected linked healthcare data. Electronic medical records provided maternal diabetes status and offspring weight at birth and ages 1 and 5 years (n = 147,773 mother child pairs). Logistic regression models were used to obtain odds ratios to describe the association between maternal diabetes status and offs...

  15. Predictive risk factors for chronic regional and multisite musculoskeletal pain: a 5-year prospective study in a working population.

    Herin, Fabrice; Vézina, Michel; Thaon, Isabelle; Soulat, Jean-Marc; Paris, Christophe

    2014-05-01

    The role of psychosocial and physical factors in the development of musculoskeletal pain (MSP) has now been clearly demonstrated. However, it is unclear whether these factors contribute to specific regional MSP or to multisite pain. The main goal of this study was to assess the impact of work-related factors according to gender on the development of regional and multisite MSP. A total of 12,591 subjects (65% men and 35% women) who were born in 1938, 1943, 1948, and 1953 and were participating in a French longitudinal prospective epidemiological survey (ESTEV) in 1990 to 1995 were eligible. Personal factors and work exposure were assessed by self-administered questionnaires. Statistical associations between chronic MSP (regional body site or multisite), personal factors, and occupational factors were analyzed using logistic regression modeling. The incidence of regional MSP and multisite pain in 1995 were, respectively, 17% and 25.6%. For women, highly repetitive movements predicted neck/shoulder pain; posture and vibrations predicted arm and low back pain; and effort with tools predicted arm pain. For men, forceful effort and vibrations predicted neck/shoulder pain; posture and forceful effort predicted lower limb and low back pain; and forceful effort and effort with tools predicted arm pain. Physical constraints (ie, forceful effort or vibrations) were associated with multisite pain in both genders. Only for women, psychological factors were risk factors predictive of upper limb pain and in 3 or 4 painful anatomical sites. These results support the hypothesis that some physical and psychological work-related factors are predictive of regional or multisite MSP but differ according to gender. Gender differences and risk factors for work-related musculoskeletal pain should be also taken into account to more effectively target preventive measures. PMID:24561229

  16. Longitudinal MRI Study of Cortical Development through Early Childhood in Autism

    Schumann, C.M.; Bloss, C.S.; Barnes, C. Carter; Wideman, G.M.; Carper, R.A.; Akshoomoff, N.; Pierce, K; Hagler, D.; Schork, N; Lord, C; Courchesne, E

    2010-01-01

    Cross-sectional MRI studies have long hypothesized that the brain in children with autism undergoes an abnormal growth trajectory that includes a period of early overgrowth; however this has never been confirmed by a longitudinal study. We carried out the first longitudinal study of brain growth in toddlers at the time symptoms of autism are becoming clinically apparent utilizing structural MRI scans at multiple time points beginning at 1.5 years up to 5 years of age. We collected 193 scans o...

  17. Cardio-metabolic risk in 5-year-old children prenatally exposed to maternal psychosocial stress: the ABCD study

    Stronks Karien

    2010-05-01

    Full Text Available Abstract Background Recent evidence, both animal and human, suggests that modifiable factors during fetal and infant development predispose for cardiovascular disease in adult life and that they may become possible future targets for prevention. One of these factors is maternal psychosocial stress, but so far, few prospective studies have been able to investigate the longer-term effects of stress in detail, i.e. effects in childhood. Therefore, our general aim is to study whether prenatal maternal psychosocial stress is associated with an adverse cardio-metabolic risk profile in the child at age five. Methods/design Data are available from the Amsterdam Born Children and their Development (ABCD study, a prospective birth cohort in the Netherlands. Between 2003-2004, 8,266 pregnant women filled out a questionnaire including instruments to determine anxiety (STAI, pregnancy related anxiety (PRAQ, depressive symptoms (CES-D, parenting stress (PDH scale and work stress (Job Content Questionnaire. Outcome measures in the offspring (age 5-7 are currently collected. These include lipid profile, blood glucose, insulin sensitivity, body composition (body mass index, waist circumference and bioelectrical impedance analysis, autonomic nervous system activity (parasympathetic and sympathetic measures and blood pressure. Potential mediators are maternal serum cortisol, gestational age and birth weight for gestational age (intrauterine growth restriction. Possible gender differences in programming are also studied. Discussion Main strengths of the proposed study are the longitudinal measurements during three important periods (pregnancy, infancy and childhood, the extensive measurement of maternal psychosocial stress with validated questionnaires and the thorough measurement of the children's cardio-metabolic profile. The availability of several confounding factors will give us the opportunity to quantify the independent contribution of maternal stress during

  18. The use of non-medical/alternative treatment in multiple sclerosis. A 5 year follow-up study

    Stenager, Egon; Stenager, E N; Knudsen, Lone;

    1995-01-01

    Forty-nine patients (22 males, 27 females) were examined and interviewed with 5 years interval in order to determine the extent of the use of non-medical (alternative) treatment and whether the use influenced the natural course of multiple sclerosis (MS). Using clinical course, Kurtzke Disability...... Status scale, bladder and bowel function, neuropsychological tests, psychological tests, divorce and self-assessment score as parameters, it was found that non-medical treatment did not alter the course of MS. To confirm this result a clinical trial in a controlled design is needed. The use of non-medical...... treatment declined over the 5 years from 55% to 27%. The use of non-medical treatment could be interpreted as an indicator of psycho-social difficulties in MS patients....

  19. Maternal Pre-Pregnancy BMI and Intelligence Quotient (IQ) in 5-Year-Old Children: A Cohort Based Study

    Bliddal, Mette; Olsen, Jørn; Støvring, Henrik; Eriksen, Hanne-Lise F.; Kesmodel, Ulrik S.; Sørensen, Thorkild I A; Nøhr, Ellen A.

    2014-01-01

    Background An association between maternal pre-pregnancy BMI and childhood intelligence quotient (IQ) has repeatedly been found but it is unknown if this association is causal or due to confounding caused by genetic or social factors. Methods We used a cohort of 1,783 mothers and their 5-year-old children sampled from the Danish National Birth Cohort. The children participated between 2003 and 2008 in a neuropsychological assessment of cognitive ability including IQ tests taken by both the mo...

  20. Psychiatric disorders and suicide attempts in Swedish survivors of the 2004 southeast Asia tsunami : a 5 year matched cohort study

    Arnberg, Filip K.; Gudmundsdóttir, Ragnhildur; Butwicka, Agnieszka; Fang, Fang; Lichtenstein, Paul; Hultman, Christina M; Valdimarsdóttir, Unnur A.

    2015-01-01

    Background Survivors of natural disasters are thought to be at an increased risk of psychiatric disorders, however the extent of this risk, and whether it is linked to pre-existing psychopathology, is not known. We aimed to establish whether Swedish survivors of tsunamis from the 2004 Sumatra–Andaman earthquake had increased risks of psychiatric disorders and suicide attempts 5 years after repatriation. Methods We identified Swedish survivors repatriated from southeast Asia (8762 adults and 3...

  1. Longitudinal Phase Space Studies at PITZ

    Roensch, J R

    2005-01-01

    The main goal of the Photo Injector Test facility at DESY Zeuthen (PITZ) is to test and to optimize photo injectors for Free-Electron Lasers (FELs). The demands on such a photo injector are small transverse emittances, short bunches and a high bunch charge. A FEL is driven by an accelerator which consists of a rf gun followed by an acceleration section and a magnetic bunch compressor. For the effective bunch compression detailed studies of the longitudinal phase space have to be performed. The correlation between the positions of the particles in the bunch and their longitudinal momenta has to be understood and the non-linearities of the longitudinal phase space have to be analysed. A special apparatus for longitudinal phase space tomography at 5 MeV using a dipole, a Cherenkov radiator, an optical transmission line and a streak camera was developed. Results of longitudinal phase space measurements are presented and compared with simulations.

  2. Effects of up to 5 years of denosumab treatment on bone histology and histomorphometry: the FREEDOM study extension.

    Brown, Jacques P; Reid, Ian R; Wagman, Rachel B; Kendler, David; Miller, Paul D; Jensen, Jens-Erik Beck; Bolognese, Michael A; Daizadeh, Nadia; Valter, Ivo; Zerbini, Cristiano A F; Dempster, David W

    2014-09-01

    Denosumab reduced bone resorption, increased bone mineral density (BMD), and decreased new vertebral, hip, and nonvertebral fracture risk in postmenopausal women with osteoporosis in the FREEDOM trial. Consistent with its mechanism of action, transiliac crest bone biopsies from subjects treated with denosumab for 1 to 3 years demonstrated reduced bone turnover that was reversible upon treatment cessation. Long-term denosumab treatment for up to 6 years in the FREEDOM extension provides sustained bone turnover reduction and continued low fracture incidence. Here, we evaluate 5 years of denosumab treatment on bone remodeling at the tissue level. Transiliac crest bone biopsies were obtained from 41 subjects (13 cross-over and 28 long-term from the FREEDOM placebo and denosumab groups, respectively) at year 2 of the FREEDOM extension, representing up to 5 years of denosumab treatment. Demographics for this subset were comparable to the overall extension cohort. The mean (SD) duration from the last denosumab dose to the first dose of tetracycline was 5.7 (0.5) months. Qualitative bone histology assessed in all biopsy samples was unremarkable, showing normally mineralized lamellar bone. Structural indices, including trabecular bone volume, number, and surface, were similar between cross-over and long-term groups. Bone resorption was decreased as reflected by eroded surface in cross-over and long-term subjects. A total of 11 of 13 (85%) cross-over subjects and 20 of 28 (71%) long-term subjects had specimens with double or single tetracycline label in trabecular and/or cortical compartments; specimens from 5 cross-over subjects and 10 long-term subjects were evaluable for dynamic trabecular bone parameters. Dynamic remodeling indices were low for both groups and consistent with reduced bone turnover with denosumab. In conclusion, denosumab treatment through 5 years resulted in normal bone quality with reduced bone turnover. These observations are consistent with its

  3. Effects of a Randomized Reading Intervention Study Aimed at 9-Year-Olds: A 5-Year Follow-up.

    Wolff, Ulrika

    2016-05-01

    The present paper reports on a 5-year follow-up of a randomized reading intervention in grade 3 in Sweden. An intervention group (n = 57) received daily training for 12 weeks in phoneme/grapheme mapping, reading comprehension and reading speed, whereas a control group (n = 55) participated in ordinary classroom activities. The main aim was to investigate if there were remaining effects of the intervention on reading-related skills. Previous analyses showed that the intervention group performed significantly better than the control group on spelling, reading speed, reading comprehension and phoneme awareness at the immediate post-test with sustained effects 1 year later. Results from the 5-year follow-up show that the only significant difference between the intervention (n = 47) and the control group (n = 37) was on word decoding. There was also a significant interaction effect of group assignment and initial word decoding, in the way that the lowest-performing students benefitted the most from the intervention. Another aim was to examine if the children identified in a screening (n = 2212) as poor readers in grade 2 still performed worse than typical readers. The analyses showed that the typically developing students (n = 66) outperformed the students identified as poor readers in grade 2 on working memory, spelling, reading comprehension and word decoding. Copyright © 2016 John Wiley & Sons, Ltd. PMID:27146373

  4. Fukushima, 5 years after

    This publication proposes an overview of the situation in Fukushima (in the plant and in its region), 5 years after the accident. As far as the plant is concerned, several issues are addressed: the withdrawal of fuel from decay pools, the management of contaminated waters, and the situation of reactors 1, 2 and 3. The radiological impact for operators is discussed in terms of radioactivity level, of occurrence of leukaemia, and of storage of radioactive wastes. The next part comments the slow return of populations and the recovery of agriculture, notably with respect to decontamination advances, and to waste management. Current perspectives for the Japanese nuclear industry are then addressed: creation of a new and stronger safety authority, and situation of the various other reactors (some are planned to be restarted, some will be dismantled, and new reactors are still being built). The last part addresses the rehabilitation of areas devastated by the tsunami, with temporary housing, urban planning comprising possibilities for the population to quickly find a shelter, and works on the coast for a better protection against tsunamis

  5. Maternal Pre-Pregnancy BMI and Intelligence Quotient (IQ) in 5-Year-Old Children: A Cohort Based Study

    Bliddal, Mette; Olsen, Jørn; Støvring, Henrik;

    2014-01-01

    -old children sampled from the Danish National Birth Cohort. The children participated between 2003 and 2008 in a neuropsychological assessment of cognitive ability including IQ tests taken by both the mother and the child. Linear regression analyses were used to estimate the associations between parental BMI......BACKGROUND: An association between maternal pre-pregnancy BMI and childhood intelligence quotient (IQ) has repeatedly been found but it is unknown if this association is causal or due to confounding caused by genetic or social factors. METHODS: We used a cohort of 1,783 mothers and their 5-year...... and child IQ adjusted for a comprehensive set of potential confounders. Child IQ was assessed with the Wechsler Primary and Preschool Scales of Intelligence--Revised (WPPSI-R). RESULTS: The crude association between maternal BMI and child IQ showed that BMI was adversely associated with child IQ with...

  6. A database study that identifies genes whose expression correlates, negatively or positively, with 5-year survival of cancer patients

    Stein, Wilfred D; Litman, Thomas; Fojo, Tito;

    2007-01-01

    A published microarray gene expression database containing data on 174 tumor samples from ten tissues was mined, enabling the identification of classes of genes whose expression correlates significantly with the intractability, or tractability, to therapy of tumors derived from such tissues. As a...... measure of tractability, the 5-year survival of patients presenting with distant (metastatic) tumors was used. Genes that encode proteins related to cell adhesion, and enzymes involved in metabolic oxidation or reduction, were upregulated in intractable cancers. Genes that encode proteins implicated in...... the control of DNA transcription were downregulated in the intractable cancers. We describe hypotheses with regard to cell functions that may help in designing new therapeutic modalities, aimed at improving survival of cancer patients....

  7. Longitudinal study on osteoarthritis and bone metabolism

    L Postiglione; Savastano, S; A. Scognamiglio; G. Nutile; Carpinelli, A; Esposito, A.; del Puente, A; Padula, S.; Oriente, P

    2011-01-01

    Objective: The relationship between Osteoarthritis (OA) and Osteoporosis (OP) is not well defined due to lacking in longitudinal data, mainly regarding correlations between biochemical factors and OA incidence. Aim of this paper was to investigate the predictive value for OA incidence of bone mass variations and of selected biochemical markers in healthy women participating in a population-based longitudinal study carried out in Naples (Italy). Subjects and Methods: High completion rate (85.2...

  8. Prevalence of respiratory diseases in hospitalized patients in Saudi Arabia: A 5 years study 1996-2000

    Alamoudi Omer

    2006-01-01

    Full Text Available OBJECTIVES: 1 To determine the prevalence of respiratory diseases and the length of stay among hospitalized patients with respiratory disorders 2 To detect the medical disorders commonly associated with respiratory diseases. MATERIALS AND METHODS: A retrospective review was done for 810 patients hospitalized with respiratory diseases in King Abdulaziz University Hospital, Jeddah, Saudi Arabia, over 5 years (January 1996 to December 2000. A special form was used to collect information from patient medical records including demographic data (such as age, sex and nationality, discharge diagnosis with other associated diseases and length of stay during hospitalization. RESULTS: Fifty-five percent of patients were males and 56.3% were Saudis. The mostly affected age group was 46-65 years (41.8%. Asthma (38.6%, chronic obstructive pulmonary disease (COPD (17.2%, pneumonia (11.5%, lung cancer (8.4% and tuberculosis (TB (7.2% had the highest prevalence among hospitalized patients. Asthma was higher among females (63.3% than males (36.7%. In contrast, lung cancer, COPD and TB were higher among males (88.2, 66.9 and 74.1% than females (11.8, 33.1 and 25.9% respectively ( P P CONCLUSION: Asthma, COPD and pneumonia were the leading causes of hospitalization among patients with respiratory disorders, while diabetes and hypertension were the most commonly associated diseases.

  9. The Effect of Correctional Education on Postrelease Employment and Recidivism: A 5-Year Follow-Up Study in the State of Indiana

    Lockwood, Susan; Nally, John M.; Ho, Taiping; Knutson, Katie

    2012-01-01

    Research has consistently revealed that released offenders, if unemployed and uneducated, would likely become recidivist offenders. This study was a 5-year follow-up study (2005-2009) of 6,561 offenders who were released from the Indiana Department of Correction (IDOC) to five metropolitan counties during the calendar year 2005. It examined the…

  10. Mood reactivity rather than cognitive reactivity is predictive of depressive relapse : a randomized study with 5.5-year follow-up

    van Rijsbergen, Gerard D; Bockting, Claudi L H; Burger, Huibert; Spinhoven, Philip; Koeter, Maarten W J; Ruhe, Eric; Hollon, Steven D; Schene, Aart H

    2013-01-01

    OBJECTIVE: The current study examined whether cognitive reactivity, cognitive extremity reactivity, and mood reactivity following mood provocation predicted relapse in depression over 5.5 years. Additionally, this study was the 1st to examine whether changes in cognitive reactivity and mood reactivi

  11. Mood Reactivity Rather than Cognitive Reactivity Is Predictive of Depressive Relapse: A Randomized Study with 5.5-Year Follow-Up

    van Rijsbergen, Gerard D.; Bockting, Claudi L. H.; Burger, Huibert; Spinhoven, Philip; Koeter, Maarten W. J.; Ruhe, Henricus G.; Hollon, Steven D.; Schene, Aart H.

    2013-01-01

    Objective: The current study examined whether cognitive reactivity, cognitive extremity reactivity, and mood reactivity following mood provocation predicted relapse in depression over 5.5 years. Additionally, this study was the 1st to examine whether changes in cognitive reactivity and mood reactivity following preventive cognitive therapy (PCT)…

  12. A prospective 5-year study of fixed partial prostheses supported by implants with machined and TiO2-blasted surface

    Gotfredsen, K; Karlsson, U

    2001-01-01

    PURPOSE: The aim of the present study was to evaluate whether there was a difference between machined and TiO(2)-blasted implants regarding survival rate and marginal bone loss during a 5-year observation period. MATERIALS AND METHODS: A total of 133 implants (Astra Tech Dental Implants; Astra Tech...... 1 TiO(2)-blasted implant. The implant-supported fixed partial prostheses (ISFPP) were fabricated within 2 months after postoperative healing. A total of 52 ISFPP (17 maxillary, 35 mandibular) were inserted. The patients were clinically examined once a year for 5 years. At the annual follow......-up, biological as well as technical complications were recorded. RESULTS: Of the 133 implants placed, 3 were reported as failed after 5 years of follow-up, resulting in an overall cumulative survival rate of 97.6%. The cumulative implant survival rates were 100% for the TiO(2)-blasted implants and 95.1% for the...

  13. Longitudinal HIV Risk Behavior among the Drug Abuse Treatment Outcome Studies (DATOS) Adult Sample

    Murphy, Debra A.; Brecht, Mary-Lynn; Herbeck, Diane; Evans, Elizabeth; Huang, David; Hser, Yih-Ing

    2008-01-01

    Longitudinal trajectories for HIV risk were examined over 5 years following treatment among 1,393 patients who participated in the nationwide Drug Abuse Treatment Outcome Studies. Both injection drug use and sexual risk behavior declined over time, with most of the decline occurring between intake and the first-year follow-up. However, results of…

  14. Maternal pre-pregnancy BMI and intelligence quotient (IQ in 5-year-old children: a cohort based study.

    Mette Bliddal

    Full Text Available BACKGROUND: An association between maternal pre-pregnancy BMI and childhood intelligence quotient (IQ has repeatedly been found but it is unknown if this association is causal or due to confounding caused by genetic or social factors. METHODS: We used a cohort of 1,783 mothers and their 5-year-old children sampled from the Danish National Birth Cohort. The children participated between 2003 and 2008 in a neuropsychological assessment of cognitive ability including IQ tests taken by both the mother and the child. Linear regression analyses were used to estimate the associations between parental BMI and child IQ adjusted for a comprehensive set of potential confounders. Child IQ was assessed with the Wechsler Primary and Preschool Scales of Intelligence--Revised (WPPSI-R. RESULTS: The crude association between maternal BMI and child IQ showed that BMI was adversely associated with child IQ with a reduction in IQ of -0.40 point for each one unit increase in BMI. This association was attenuated after adjustment for social factors and maternal IQ to a value of -0.27 (-0.50 to -0.03. After mutual adjustment for the father's BMI and all other factors except maternal IQ, the association between paternal BMI and child IQ yielded a regression coefficient of -0.26 (-0.59 to 0.07, which was comparable to that seen for maternal BMI (-0.20 (-0.44 to 0.04. CONCLUSION: Although maternal pre-pregnancy BMI was inversely associated with the IQ of her child, the similar association with paternal BMI suggests that it is not a specific pregnancy related adiposity effect.

  15. Multi-disciplinary management for patients with oligometastases to the brain: results of a 5 year cohort study

    The incidence of oligometastases to the brain in good performance status patients is increasing due to improvements in systemic therapy and MRI screening, but specific management pathways are often lacking. We established a multi-disciplinary brain metastases clinic with specific referral guidelines and standard follow-up for good prognosis patients with the view that improving the process of care may improve outcomes. We evaluated patient demographic and outcome data for patients first seen between February 2007 and November 2011. The clinic was feasible to run and referrals were appropriate. 87% of patients referred received a localised therapy during their treatment course. 114 patients were seen and patient numbers increased during the 5 years that the clinic has been running as relationships between clinicians were developed. Median follow-up for those still alive was 23.1 months (6.1-79.1 months). Primary treatments were: surgery alone 52%, surgery plus whole brain radiotherapy (WBRT) 9%, radiosurgery 14%, WBRT alone 23%, supportive care 2%. 43% received subsequent treatment for brain metastases. 25%, 11% and 15% respectively developed local neurological progression only, new brain metastases only or both. Median overall survival following brain metastases diagnosis was 16.0 months (range 1–79.1 months). Breast (32%) and NSCLC (26%) were the most common primary tumours with median survivals of 26 and 16.9 months respectively (HR 0.6, p=0.07). Overall one year survival was 55% and two year survival 31.5%. 85 patients died of whom 37 (44%) had a neurological death. Careful patient selection and multi-disciplinary management identifies a subset of patients with oligometastatic brain disease who benefit from aggressive local treatment. A dedicated joint neurosurgical/ neuro-oncology clinic for such patients is feasible and effective. It also offers the opportunity to better define management strategies and further research in this field. Consideration should be

  16. Corporal Punishment and Child Behavioural and Cognitive Outcomes through 5?Years of Age: Evidence from a Contemporary Urban Birth Cohort Study

    MacKenzie, Michael J.; Nicklas, Eric; Waldfogel, Jane; Brooks-Gunn, Jeanne

    2012-01-01

    This study examined the prevalence and determinants of spanking of children at 3?years of age and the associations between spanking and externalizing behaviour and receptive verbal ability at age 5?years. Overall, we find maternal spanking rates of 55.2% and paternal rates of 43.2% at age 3?years. Mothers facing greater stress and those who…

  17. Do energy density and dietary fiber influence subsequent 5-year weight changes in adult men and women?

    Iqbal, Sofia I; Helge, Jørn W; Heitmann, Berit L

    2006-01-01

    OBJECTIVE: We examined whether associations between dietary components and, in particular, energy density (ED) predicted subsequent 5-year weight changes. RESEARCH METHODS AND PROCEDURES: The present longitudinal population study was part of the Danish World Health Organization Multinational Moni...

  18. Relationship between indication for tooth extraction and outcome of immediate implants: a retrospective study with 5 years of follow-up

    Tarazona Alvarez, Beatriz; Tarazona Álvarez, Pablo; Peñarrocha Oltra, David; Peñarrocha Diago, María

    2014-01-01

    Objectives: The aims of this retrospective study were to evaluate the survival rate of a series of immediate implants after 3 years of follow-up and to study the relationship between survival and indication for tooth extraction. Study Design: A retrospective study of patients treated with immediate implants between January 2003 and December 2008 was carried out. All patients receiving at least one post-extraction implant and a minimum follow-up of 5 years were included. Results: After 60 mont...

  19. Study of CSR longitudinal bunch compression cavity

    The scheme of longitudinal bunch compression cavity for the Cooling Storage Ring (CSR)is an important issue. Plasma physics experiments require high density heavy ion beam and short pulsed bunch,which can be produced by non-adiabatic compression of bunch implemented by a fast compression with 90 degree rotation in the longitudinal phase space. The phase space rotation in fast compression is initiated by a fast jump of the RF-voltage amplitude. For this purpose, the CSR longitudinal bunch compression cavity, loaded with FINEMET-FT-1M is studied and simulated with MAFIA code. In this paper, the CSR longitudinal bunch compression cavity is simulated and the initial bunch length of 238U72+ with 250 MeV/u will be compressed from 200 ns to 50 ns.The construction and RF properties of the CSR longitudinal bunch compression cavity are simulated and calculated also with MAFIA code. The operation frequency of the cavity is 1.15 MHz with peak voltage of 80 kV, and the cavity can be used to compress heavy ions in the CSR. (authors)

  20. A STUDY OF RELATIONSHIP BETWEEN WEIGHT, HEIGHT, HEAD & CHEST CIRCUMFERENCE IN CHILDREN BETWEEN 3 TO 5 YEARS IN THE MALWA REGION OF MADHYA PRADESH

    Wankhede

    2015-04-01

    Full Text Available INTRODUCTION : The growth & development are the important attributes of childhood. The studies on physical development & growth of infants & children are important as they are determinants of a nation’s health. The appr eciation of progress of any country in the field of health can be made from time to time with the help of such studies. The principal aim of the nutritional assessment of a community is to map out the magnitude & geographic distribution of malnutrition & a public health problem to find out the ecological factor & where possible to suggest appropriate corrective measures. AIMS & OBJECTIVES : To determine the anthropometric measurements of the pre - school age children in both sexes, to study the growth spurt & velocity of growth in the children between 3 & 5 years, to construct selected percentiles of the various measurements for boys & girls in Malwa region & to compare the figures obtained by anthropometric studies with those determined by other workers in th e different regions. MATERIALS & METHOD: A cross sectional study of weight, height, circumference of head, chest & arm of school going children ranging from 3 to 5 years in age was carried out in the city of Indore. Total 1, 000 children, belonging to both low & high socio - economic status, were examined. OBSERVATIONS: The mean values of head & chest circumferences shows a gradual increase with in both sexes. The mean value of the mid - arm circumference also shows an increase with increasing age on both sexes . As regards the height, the mean value is a bit higher in females at 3 . 5 years & 4 . 5 years as compared to Males at 3, 3 . 5, 4 & 5 years of age. The mean values of weight are more in females than males at the age of 4, 4 . 5 & 5 years. SUMMARY & CONCLUSION : A nthropometric studies were carried out in all children uniformly by determining weight, height and circumferences of head, chest & mid - arm. The head & chest circumferences equalizes at the age of 3

  1. Predictors of heroin relapse: Personality traits, impulsivity, COMT gene Val158met polymorphism in a 5-year prospective study in Shanghai, China.

    Su, Hang; Li, Zhibin; Du, Jiang; Jiang, Haifeng; Chen, Zhikang; Sun, Haiming; Zhao, Min

    2015-12-01

    Relapse is a typical feature of heroin addiction and rooted in genetic and psychological determinants. The aim of this study was to evaluate the effect of personality traits, impulsivity, and COMT gene polymorphism (rs4680) on relapse to heroin use during 5-year follow up. 564 heroin dependent patients were enrolled in compulsory drug rehabilitation center. 12 months prior to their release, personality traits were measured by BIS-11 (Barratt Impulsiveness Scale-11) and Temperament and Character Inventory (TCI). The COMT gene rs4680 polymorphism was genotyped using a DNA sequence detection system. The heroin use status was evaluated for 5 years after discharged. Among the 564 heroin-dependent patients, 500 were followed for 5 years after discharge and 53.0% (n = 265) were considered as relapsed to heroin use according to a strict monitor system. Univariate analysis showed that age, having ever been in methadone maintenance treatment (MMT), the total scores and non-planning scores of BIS-11, and the COMT rs4680 gene variants were different between relapse and abstinent groups. Logistic regression analysis showed higher BIS total score, having ever been in MMT and younger first heroin use age are the predictors of relapse to heroin use during 5 years follow-up, and the COMT rs4680 gene had an interaction with BIS scores. Our findings indicated that the impulsive personality traits, methadone use history, and onset age could predict relapse in heroin-dependent patients during 5 year's follow up. The COMT gene showed a moderational effect in part the relationship of impulsivity with heroin relapse. PMID:26345603

  2. Interracial contact and racial constancy: A multi-site study of racial intergroup bias in 3-5 year old Anglo-British children

    Rutland, Adam; Cameron, Lindsey; Bennett, Laura; Ferrell, Jennifer M.

    2005-01-01

    This paper examined the influence of interracial contact and racial constancy on the racial intergroup bias of young Anglo-British children. This multi-site study was conducted in areas of Great Britain that varied in terms of racial diversity. The study also investigated whether preschool children express bias on positive, but not negative, valence attributions. Anglo-British children (N = 136) between 3 and 5 years of age with different levels of interracial contact undertook a racial stere...

  3. Response rates to oestrogen treatment in perimenopausal women: 5-year data from the Danish Osteoporosis Prevention Study (DOPS)

    Rejnmark, Lars; Vestergaard, P; Tofteng, Charlotte; Jensen, L B; Bärenholdt, O; Pors Nielsen, S; Abrahamsen, Bo; Brixen, K; Mosekilde, Leif

    2004-01-01

    OBJECTIVE: To characterise women with no response or with a good response to hormone replacement therapy (HRT), evaluated by change in bone mineral density (BMD). Design: Nested case-control study within a comprehensive cohort study. SUBJECTS AND METHODS: In the Danish Osteoporosis Prevention Stu...

  4. Sex differences in 30-day and 5-year outcomes after endovascular repair of abdominal aortic aneurysms in the EUROSTAR study

    Grootenboer, Nathalie; Hunink, M G Myriam; Hendriks, Johanna M; van Sambeek, Marc R H M; Buth, Jaap

    2013-01-01

    The purpose of this study was to determine the effect of sex on 30-day and long-term outcomes after elective endovascular aneurysm repair.......The purpose of this study was to determine the effect of sex on 30-day and long-term outcomes after elective endovascular aneurysm repair....

  5. Self-experience in the early phases of schizophrenia: 5-year follow-up of the Copenhagen Prodromal Study

    Parnas, Josef; Raballo, Andrea; HANDEST, PETER; Jansson, Lennart; VOLLMER-LARSEN, ANNE; Saebye, Ditte

    2011-01-01

    Despite the avalanche of empirical data on prodromal/”at risk” conditions, the essential aspects of the vulnerability to the schizophrenia spectrum remain largely unaddressed. We report here the results of the Copenhagen Schizophrenia Prodromal Study, a prospective, observational study of first admission patients in putative state of beginning psychosis (N=151) with a follow-up length of 60 months. At follow-up, the rate of conversion to schizophrenia spectrum diagnosis was ...

  6. Parenting style, the home environment, and screen time of 5-year-old children; the 'be active, eat right' study

    L. Veldhuis (Lydian); A. van Grieken (Amy); C.M. Renders (Carry); R.A. Hirasing (Remy); H. Raat (Hein)

    2014-01-01

    textabstractIntroduction: The global increase in childhood overweight and obesity has been ascribed partly to increases in children's screen time. Parents have a large influence on their children's screen time. Studies investigating parenting and early childhood screen time are limited. In this stud

  7. Mandibular overdentures supported by two Bra°nemark, IMZ or ITI implants : a 5-year prospective study

    Meijer, Henny J.A.; Batenburg, Rutger H.K.; Raghoebar, Gerry M.; Vissink, Arjan

    2004-01-01

    Objectives: The aim of this prospective comparative study was to evaluate the survival rate and the condition of the peri-implant tissues of the IMZ implant system (two-stage cylindertype), the Bra°nemark implant system (two-stage screwtype) and the ITI implant system (one-stage screwtype) supportin

  8. A Cross-sectional Study for Determinations of Prevention Behaviors of Domestic Accidents in Mothers with Children Less than 5- year

    Farbod Ebadi Fardazar

    2016-05-01

    Full Text Available Background: Accidents are the first cause of death in children under 5- year, especially in low- and middle-income countries. The aim of this study was to identify the determinants of prevention behavior of domestic accidents in mothers of children fewer than 5 years old based on protection motivation theory PMT(. Materials and Methods: In this cross-sectional descriptive-analytic study, 190 mothers were randomly selected. The data collection tool was researcher made questionnaire about prevention behaviors of home accidents in children less than five years based on the structures of protection motivation theory.then collected data entered in the software SPSS-22 and were analyzed using descriptive and analytical statistical tests. Results: Mean of perceived response efficacy was in good level and mean of other structures of PMT were in moderate level. There was a significant correlations between the scores of perceived vulnerability (r=.39, P

  9. Self-experience in the early phases of schizophrenia: 5-year follow-up of the Copenhagen Prodromal Study

    Parnas, Josef; Raballo, Andrea; Handest, Peter;

    2011-01-01

    admission patients in putative state of beginning psychosis (N=151) with a follow-up length of 60 months. At follow-up, the rate of conversion to schizophrenia spectrum diagnosis was 37%, whereas the conversion rate from schizotypal disorder to schizophrenia was 25%. High levels of perplexity and self......Despite the avalanche of empirical data on prodromal/"at risk" conditions, the essential aspects of the vulnerability to the schizophrenia spectrum remain largely unaddressed. We report here the results of the Copenhagen Schizophrenia Prodromal Study, a prospective, observational study of first......-disorders baseline scores yielded the best prediction of the subsequent development of schizophrenia spectrum disorders. Escalating transitions within the spectrum (i.e., from schizotypal disorder to schizophrenia) were not associated to any candidate psychopathological predictor....

  10. Impact of a pharmaceutical care program on clinical evolution and antiretroviral treatment adherence: a 5-year study

    Hernández Arroyo MJ

    2013-08-01

    Full Text Available María Jesús Hernández Arroyo,1 Salvador Enrique Cabrera Figueroa,2 Rosa Sepúlveda Correa,3 María de la Paz Valverde Merino,1 Alicia Iglesias Gómez,4 Alfonso Domínguez-Gil Hurlé5 On behalf of the Tormes Team 1Pharmacy Service, University Hospital of Salamanca, Salamanca, Spain; 2Pharmacy Institute, University Austral of Chile, Valdivia, Chile; 3Department of Statistics, University of Salamanca, Salamanca, Spain; 4Infectious Disease Service, University Hospital of Salamanca, Salamanca, Spain; 5Department of Pharmacy and Pharmaceutical Technology, University of Salamanca, Salamanca, Spain Background: Antiretroviral treatments (ART form the basis of adequate clinical control in human immunodeficiency virus-infected patients, and adherence plays a primary role in the grade and duration of the antiviral response. The objectives of this study are: (1 to determine the impact of the implementation of a pharmaceutical care program on improvement of ART adherence and on the immunovirological response of the patients; and (2 to detect possible correlations between different adherence evaluation measurements. Methods: A 60-month long retrospective study was conducted. Adherence measures used were: therapeutic drug monitoring, a simplified medication adherence questionnaire, and antiretroviral dispensation records (DR. The number of interviews and interventions related to adherence made for each patient in yearly periods was related to the changes in the adherence variable (measured with DR in these same yearly periods. The dates when the laboratory tests were drawn were grouped according to proximity with the study assessment periods (February–May, 2005–2010. Results: A total of 528 patients were included in the study. A significant relationship was observed between the simplified medication adherence questionnaire and DR over the 60-month study period (P < 0.01. Improvement was observed in the mean adherence level (P < 0.001, and there was a

  11. Longitudinal study of fingerprint recognition

    Yoon, Soweon; Anil K Jain

    2015-01-01

    Fingerprint recognition, which is considered to be a reliable means for human identification, has been used in many applications ranging from law enforcement and forensics to unlocking mobile phones. Despite its successful deployment, the fundamental premise of fingerprint-based identification—persistence and uniqueness of fingerprints—has not yet been well studied, resulting in challenges to the admissibility of friction ridge evidence in courts of law. This study investigates the tendency o...

  12. Do the more caries in early primary dentition indicate the more caries in permanent dentition? Results of a 5-years follow-up study in rural-district

    Dülgergil, C. T.; Çolak, H.

    2012-01-01

    Aim: In the deprived communities with high caries incidence, determination of high-risk children in early age is a valuable tool to apply the individual and/or community-level preventive measures. The purpose of this 5-years follow-up study was to examine the relationship between early caries occurrence on primary incisors and the future caries occurrence on both first permanent molars and all permanent dentition in the children living in rural Turkey. Materials and Methods: Total 34 children...

  13. Better off in the community? A 5-year follow up study of long-term psychiatric patients discharged into the community.

    McInerney, Shane J

    2010-04-01

    The quality of life of long-term psychiatric inpatients relocated to the community was investigated in this study. The aim was to investigate what changes, if any occurred, on standardised quality of life related instruments between discharge from hospital and at 1 year after discharge into the community. We were also interested to see if these changes continued 5 years after discharge into the community.

  14. Quality of life impact of treatments for localized prostate cancer: Cohort study with a 5 year follow-up

    Purpose: To assess long-term quality of life (QoL) impact of treatments in localized prostate cancer patients treated with radical prostatectomy, external beam radiotherapy or brachytherapy. Material and methods: Observational, prospective cohort study with pre-treatment QoL evaluation and follow-up until five years after treatment. 704 patients with low or intermediate risk localized prostate cancer were consecutively recruited in 2003–2005. QoL was measured by the EPIC questionnaire, with urinary irritative–obstructive, incontinence, bowel, sexual, and hormonal scores (ranging 0–100). Results: Brachytherapy’s QoL impact was restricted to the urinary domain, Generalized Estimating Equation models showed score changes at five years of −12.0 (95% CI = −15.0, −9.0) in incontinence and −5.3 (95% CI = −7.5, −3.1) in irritative–obstructive scales. Compared to brachytherapy, radical prostatectomy fared +3.3 (95% CI = +0.0, +6.5) points better in irritative–obstructive but −17.1 (95% CI = −22.7, −11.5) worse in incontinence. Sexual deterioration was observed in radical prostatectomy (−19.1; 95% CI = −25.1, −13.1) and external radiotherapy groups (−7.5; 95% CI = −12.5, −2.5). Conclusions: Brachytherapy is the treatment causing the least impact on QoL except for moderate urinary irritative–obstructive symptoms. Our study provides novel long-term valuable information for clinical decision making, supporting brachytherapy as a possible alternative to radical prostatectomy for patients seeking an attempted curative treatment, while limiting the risk for urinary incontinence and sexual impact on QoL

  15. Clinical outcome of 215 transmucosal implants with a conical connection: a retrospective study after 5-year follow-up.

    Lopez, M A; Andreasi Bassi, M; Confalone, L; Gaudio, R M; Lombardo, L; Lauritano, D

    2016-01-01

    The purpose of this retrospective clinical study was to evaluate the survival rate (i.e. SVR – fixtures still in place at the end of the observation period) and success rate (i.e. SCR - bone resorption around implant neck) of an implant system characterized by cylindrical and tapered implants, both types of implant being equipped with a conical connection with an internal octagon (COC), both implant types having a 1.8 mm smooth neck, positioned above the bone crest level. A total of 65 subjects received 215 COCs between January 1996 and October 2011. All COCs were placed and restored by three experienced dental surgeons. The mean follow-up was 84±44 months. The patients involved in the study were both male (30) and female (35), of whom 30 were smokers (less than 20 cigarettes/day) and none was diabetic. The implants differed in terms of diameter and length, and were inserted both in the mandible (97) and in the maxilla (118). Sixty-seven implants were single tooth rehabilitations, and 148 prosthetic bridges. Fourteen had guided bone regeneration (GBR), and 10 were placed in post-extractive sites. Forty of the implants were provided with passing-screw abutments and 175 with full-screw abutments. The data were analyzed using descriptive statistics. None of the implants failed before prosthetic restoration, resulting in an SVR=100% after loading. The radiographic and clinical data revealed well-maintained, hard and soft tissue around the COCs, with an SCR=92.6%. Cox regression analyses did not detect any variables with statistical impact on the clinical outcome. In conclusion, Shiner XT implants are reliable tools for oral rehabilitation. PMID:27469549

  16. Prevalence of anterior dental trauma and its associated factors among children aged 3-5 years in Jaipur City, India – A cross sectional study

    Chalissery, Vemina P.; Marwah, Nikhil; Jafer, Mohammed; Chalisserry, Elna P.; Bhatt, Tanmay; Anil, Sukumaran

    2016-01-01

    Objective: To study the prevalence of anterior dental trauma and its associated factors among 800 preschool children aged 3 to 5 years in Jaipur City, Rajasthan, India. Materials and Methods: A cross-sectional survey was conducted among children aged 3-5 years, who were enrolled in various private and public schools in Jaipur. Parents were asked to fill a form addressing socio-demographic data and clinical examinations were performed by a single dentist. Traumatic dental injuries (TDI) were assessed and recorded based on Andreasen's classification. Associated factors such as sex, socioeconomic status (SES), and the type of injury were also analyzed. The data were analyzed statistically using Statistical Package for the Social Sciences software (version 20). Results: An overall 10.2% prevalence of TDI was observed among the study population. TDI were reported to be more among male children (11.87%) compared to female children (8.14%). Enamel fractures (69%) were the most prevalent type of anterior dental trauma. Upper central incisors were the most frequently affected. The SES of the parents had little influence on the prevalence of TDI. Conclusions: The prevalence rate of dental trauma among children aged 3-5 years was 10.2%. Associated factors, such as SES, were observed to be not significantly correlated to dental trauma among the studied preschoolers. PMID:27195225

  17. A 5-year retrospective study of demographic, anamnestic, and clinical factors related to psychiatric hospitalizations of adolescent patients

    Di Lorenzo R

    2016-01-01

    Full Text Available Rosaria Di Lorenzo,1 Nina Cimino,2 Elena Di Pietro,3 Gabriella Pollutri,4 Vittoria Neviani,5 Paola Ferri2 1Service of Psychiatric Diagnosis and Treatment, Department of Mental Health, AUSL Modena, Modena, 2School of Nursing, University of Modena and Reggio Emilia, 3School of Neuro-Psychiatry, 4School of Psychiatry, University of Modena and Reggio Emilia, 5 “The Medlar”, Villa Igea Hospital, Modena, Italy Background: Psychiatric emergencies of children and adolescents have greatly increased during the last years, but this phenomenon has not been studied in detail. The aim of this study was to analyze the correlation between acute psychiatric hospitalizations of adolescents and selected variables to highlight risk factors for psychiatric emergencies. Methods: This retrospective research was conducted in the acute psychiatric public ward, Service of Psychiatric Diagnosis and Treatment (SPDT, and in the residential facility for adolescents, “The Medlar”, located in Modena. The sample was constituted by all adolescent patients (n=101, age range 14–18 who had acute hospitalizations (n=140 in SPDT and had been successively transferred to “The Medlar” (n=83, from February 2, 2010 to January 31, 2015. From clinical charts, we extracted demographic and anamnestic characteristics of patients and clinical variables related to hospitalizations. Data were statistically analyzed. Results: Sixty-one percent of our patients lived with one divorced parent, with adoptive or immigrant family, or in institutions; 51% had experienced stressful events during childhood; 81% had a normal intellective level, but only 6% presented regular school performance. Parental psychiatric illness was negatively related, in a statistically significantly way, with onset age of adolescent mental disorders (coefficient -2.28, 95% confidence interval [CI]: -3.53 to 1.01, P<0.001, single linear regression; odds ratio: 4.39, 95% CI: 1.43–13.47, P<0.010, single logistic

  18. Sick Leave within 5 Years of Whiplash Trauma Predicts Recovery: A Prospective Cohort and Register-Based Study

    Carstensen, Tina Birgitte Wisbech; Fink, Per; Oernboel, Eva; Kasch, Helge; Jensen, Troels Staehelin; Frostholm, Lisbeth

    2015-01-01

    Background 10–22% of individuals sustaining whiplash trauma develop persistent symptoms resulting in reduced working ability and decreased quality of life, but it is poorly understood why some people do not recover. Various collision and post-collision risk factors have been studied, but little is known about pre-collision risk factors. In particular, the impact of sickness and socioeconomic factors before the collision on recovery is sparsely explored. The aim of this study was to examine if welfare payments received within five years pre-collision predict neck pain and negative change in provisional situation one year post-collision. Methods and Findings 719 individuals with acute whiplash trauma consecutively recruited from emergency departments or primary care after car accidents in Denmark completed questionnaires on socio-demographic and health factors immediately after the collision. After 12 months, a visual analogue scale on neck pain intensity was completed. 3595 matched controls in the general population were sampled, and national public register data on social benefits and any other welfare payments were obtained for participants with acute whiplash trauma and controls from five years pre-collision to 15 months after. Participants with acute whiplash trauma who had received sickness benefit for more than 12 weeks pre-collision had increased odds for negative change in future provisional situation (Odds Ratio (OR) (95% Confidence Interval (CI) = 3.8 (2.1;7.1)) and future neck pain (OR (95%CI) = 3.3 (1.8;6.3)), controlling for other known risk factors. Participants with acute whiplash trauma had weaker attachment to labour market (more weeks of sick leave (χ2(2) = 36.7, p < 0.001) and unemployment (χ2(2) = 12.5, p = 0.002)) pre-collision compared with controls. Experiencing a whiplash trauma raised the odds for future negative change in provisional situation (OR (95%CI) = 3.1 (2.3;4.4)) compared with controls. Conclusions Sick leave before the

  19. Sick Leave within 5 Years of Whiplash Trauma Predicts Recovery: A Prospective Cohort and Register-Based Study.

    Tina Birgitte Wisbech Carstensen

    Full Text Available 10-22% of individuals sustaining whiplash trauma develop persistent symptoms resulting in reduced working ability and decreased quality of life, but it is poorly understood why some people do not recover. Various collision and post-collision risk factors have been studied, but little is known about pre-collision risk factors. In particular, the impact of sickness and socioeconomic factors before the collision on recovery is sparsely explored. The aim of this study was to examine if welfare payments received within five years pre-collision predict neck pain and negative change in provisional situation one year post-collision.719 individuals with acute whiplash trauma consecutively recruited from emergency departments or primary care after car accidents in Denmark completed questionnaires on socio-demographic and health factors immediately after the collision. After 12 months, a visual analogue scale on neck pain intensity was completed. 3595 matched controls in the general population were sampled, and national public register data on social benefits and any other welfare payments were obtained for participants with acute whiplash trauma and controls from five years pre-collision to 15 months after. Participants with acute whiplash trauma who had received sickness benefit for more than 12 weeks pre-collision had increased odds for negative change in future provisional situation (Odds Ratio (OR (95% Confidence Interval (CI = 3.8 (2.1;7.1 and future neck pain (OR (95%CI = 3.3 (1.8;6.3, controlling for other known risk factors. Participants with acute whiplash trauma had weaker attachment to labour market (more weeks of sick leave (χ2(2 = 36.7, p < 0.001 and unemployment (χ2(2 = 12.5, p = 0.002 pre-collision compared with controls. Experiencing a whiplash trauma raised the odds for future negative change in provisional situation (OR (95%CI = 3.1 (2.3;4.4 compared with controls.Sick leave before the collision strongly predicted prolonged recovery

  20. Emotion and cognitive function assessment of patients with central neurocytoma resection through transcortical frontal approach: a 5-year postoperative follow-up study

    SHI Zhi-feng; SUN Da-liang; SONG Jian-ping; YAO Yu; MAO Ying

    2011-01-01

    Background Central neurocytoma accounts for 0.1% of primary brain tumor that often occurs in young adults.Surgery is the main treatment for central neurocytoma and the rate of 5-year survival reaches up to over 90%.This study aimed to assess the effect of transcortical frontal approach to surgical resection of central neurocytoma on emotion and cognitive function 5 years after surgery.Methods Telephone following-up visits were used in this study.By means of neuropsychological testing,assayed emotion,memory and abstract thinking ability of 18 patients undergoing central neurocytoma resection by transcortical frontal approach for 5 years or more,with another 21 normal cases as control group were enrolled.The data were analyzed statistically by paired t test with SPSS11.5.Results Patients whose central neurocytoma was removed by transcortical frontal approach were not affected on calculating ability 5 years after operation while ability of memory declined sharply (P=0.000),the older,the more sharply (P=0.036).Ability of abstract thinking was significantly reduced (P=0.000),the older,the more significantly as well (P=0.012);additionally,anxiety and depression occurred in patients rather more than those of control group (P=0.000),especially cognitive impairment.Conclusions Transcortical frontal approach for surgical resection of central neurocytoma has certain long-term influence on patients' life quality,vulnerable to anxiety,depression and cognitive impairment,the severity of which was correlated to age.Therefore,improving surgical approach will be of value for better long-term life quality of patients.

  1. Risk for High Depressive Symptoms in Diagnosed and Previously Undetected Diabetes: 5-Year Follow-Up Results of the Heinz Nixdorf Recall Study

    Andrea Icks; Bernd Albers; Burkhard Haastert; Sonali Pechlivanis; Noreen Pundt; Uta Slomiany; Raimund Erbel; Karl-Heinz Jöckel; Johannes Kruse; Bernd Kulzer; Bettina Nowotny; Christian Herder; Guido Giani; Susanne Moebus

    2013-01-01

    OBJECTIVE: The objective of this study was to determine the risk for the development of high depressive symptoms in study participants with diagnosed and previously undetected diabetes mellitus compared to those without diabetes in a prospective population-based cohort study in Germany. METHODS: We estimated the 5-year cumulative incidence of high depressive symptoms in participants without high depressive symptoms at baseline (n = 3,633, 51.4% men, mean age (SD) 59.1 (7.6) years, 7.0% diagno...

  2. Right and left cardiac function in HIV-infected patients investigated using radionuclide ventriculography and brain natriuretic peptide: a 5-year follow-up study

    Kristoffersen, U S; Lebech, A M; Gerstoft, J;

    2008-01-01

    ventricular ejection fraction (RVEF) and left ventricular ejection fraction (LVEF), as well as measurement of brain natriuretic peptide (BNP). Between July 2005 and January 2007, 63 patients (69%) agreed to participate in a follow-up study with a mean follow-up of 4.5 years. RESULTS: All patients had normal...... mean RVEF was found. No patients had increased BNP and no change in mean plasma BNP was found. CONCLUSIONS: HIV-related cardiomyopathy appears not to constitute a problem in closely monitored, well-treated HIV-infected patients. Compared with pre-highly active antiretroviral therapy (HAART) studies, it...

  3. Longitudinal studies of trauma in police officers

    Charles Marmar

    2012-01-01

    Background : Results will be presented on a prospective longitudinal study of risk and resilience for post-traumatic stress disorder (PTSD) symptoms in 400 police academy recruits, assessed during academy training and followed during the first 7 years of police service. Methods : Utilizing Latent Growth Mixture Modeling (LGMM) we have established three symptom trajectories, highly resilient, initially distressed with gradual improvement, and increasing distress. Results : We will present find...

  4. Parenting Style, the Home Environment, and Screen Time of 5-Year-Old Children; The ‘Be Active, Eat Right’ Study

    Veldhuis, Lydian; van Grieken, Amy; Renders, Carry M.; HiraSing, Remy A.; Raat, Hein

    2014-01-01

    Introduction The global increase in childhood overweight and obesity has been ascribed partly to increases in children's screen time. Parents have a large influence on their children's screen time. Studies investigating parenting and early childhood screen time are limited. In this study, we investigated associations of parenting style and the social and physical home environment on watching TV and using computers or game consoles among 5-year-old children. Methods This study uses baseline data concerning 5-year-old children (n = 3067) collected for the ‘Be active, eat right’ study. Results Children of parents with a higher score on the parenting style dimension involvement, were more likely to spend >30 min/day on computers or game consoles. Overall, families with an authoritative or authoritarian parenting style had lower percentages of children's screen time compared to families with an indulgent or neglectful style, but no significant difference in OR was found. In families with rules about screen time, children were less likely to watch TV>2 hrs/day and more likely to spend >30 min/day on computers or game consoles. The number of TVs and computers or game consoles in the household was positively associated with screen time, and children with a TV or computer or game console in their bedroom were more likely to watch TV>2 hrs/day or spend >30 min/day on computers or game consoles. Conclusion The magnitude of the association between parenting style and screen time of 5-year-olds was found to be relatively modest. The associations found between the social and physical environment and children's screen time are independent of parenting style. Interventions to reduce children's screen time might be most effective when they support parents specifically with introducing family rules related to screen time and prevent the presence of a TV or computer or game console in the child's room. PMID:24533092

  5. Study visit carbon sinks Peugeot. Evaluation after 5 years and perspectives; Visite d'etude Puits de Carbone Peugeot. Bilan a 5 ans et perspectives

    Grosso, M.; Sao Nicolau, F

    2005-07-01

    In the framework of its project of the climatic change control, PSA Peugeot Citroen, decided to involve in the decrease of the carbon dioxide emissions. In parallel to the vehicles consumption decrease and the biofuels utilization, the group developed since 5 years a pilot project of carbon sink. This project aims to study the impact of a trees plantation, at a big scale, on the atmospheric carbon dioxide fixation. This document is a first evaluation after the phase of trees plantation. (A.L.B.)

  6. Tea consumption is inversely related to 5-year blood pressure change among adults in Jiangsu, China: a cross-sectional study

    Tong, Xiaoliang; Taylor, Anne W.; Giles, Lynne; Wittert, Gary A.; Shi, Zumin

    2014-01-01

    Background Data relating to the association between tea consumption and blood pressure change are inconsistent. The aim of this analysis was to investigate the association between tea consumption and the change in blood pressure (BP) in Chinese adults over a 5-year period. Methods Data from 1109 Chinese men (N= 472) and women (N= 637) who participated in the Jiangsu Nutrition Study (JIN) were analysed. BP was measured in 2002 and 2007. Tea (green, black and total tea) consumption was quantita...

  7. Developmental milestones record - 5 years

    ... view (but may not understand them) Has improved math skills Questions others, including parents Strongly identifies with ... milestones for children - 5 years References Feigelman S. The preschool years. In: Kliegman RM, Behrman RE, Jenson HB, ...

  8. Negative predictive value of multiparametric MRI for prostate cancer detection: Outcome of 5-year follow-up in men with negative findings on initial MRI studies

    Highlights: • We assess the negative predictive value of multiparametric MRI for prostate cancer. • Patients with positive prostate biopsy findings were defined as false-negative. • Patients with negative initial prostate biopsy findings were followed up for 5 years. • The negative predictive value was 89.6% for significant prostate cancer. • MRI is a useful tool to rule out significant prostate cancer before biopsy. - Abstract: Objective: To assess the clinical negative predictive value (NPV) of multiparametric MRI (mp-MRI) for prostate cancer in a 5-year follow-up. Materials and methods: One hundred ninety-three men suspected of harboring prostate cancer with negative MRI findings were included. Patients with positive transrectal ultrasound (TRUS)-guided biopsy findings were defined as false-negative. Patients with negative initial TRUS-guided biopsy findings were followed up and only patients with negative findings by digital rectal examination, MRI, and repeat biopsy and no increase in PSA at 5-year follow-up were defined as “clinically negative”. The clinical NPV of mp-MRI was calculated. For quantitative analysis, mean signal intensity on T2-weighted images and the mean apparent diffusion coefficient value on ADC maps of the initial MRI studies were compared between peripheral-zone (PZ) cancer and the normal PZ based on pathologic maps of patients who had undergone radical prostatectomy. Results: The clinical NPV of mp-MRI was 89.6% for significant prostate cancer. Small cancers, prostatitis, and benign prostatic hypertrophy masking prostate cancer returned false-negative results. Quantitative analysis showed that there was no significant difference between PZ cancer and the normal PZ. Conclusion: The mp-MRI revealed a high clinical NPV and is a useful tool to rule out clinically significant prostate cancer before biopsy

  9. Negative predictive value of multiparametric MRI for prostate cancer detection: Outcome of 5-year follow-up in men with negative findings on initial MRI studies

    Itatani, R., E-mail: banguliao@gmail.com [Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto 860-8556 (Japan); Department of Radiology, Kumamoto Chuo Hospital, 1-5-1, Tainoshima, Kumamoto 862-0965 (Japan); Namimoto, T. [Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto 860-8556 (Japan); Atsuji, S.; Katahira, K.; Morishita, S. [Department of Radiology, Kumamoto Chuo Hospital, 1-5-1, Tainoshima, Kumamoto 862-0965 (Japan); Kitani, K.; Hamada, Y. [Department of Urology, Kumamoto Chuo Hospital, 1-5-1, Tainoshima, Kumamoto 862-0965 (Japan); Kitaoka, M. [Department of Pathology, Kumamoto Chuo Hospital, 1-5-1, Tainoshima, Kumamoto 862-0965 (Japan); Nakaura, T. [Department of Diagnostic Radiology, Amakusa Medical Center, Kameba 854-1, Amakusa, Kumamoto 863-0046 (Japan); Yamashita, Y. [Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Kumamoto 860-8556 (Japan)

    2014-10-15

    Highlights: • We assess the negative predictive value of multiparametric MRI for prostate cancer. • Patients with positive prostate biopsy findings were defined as false-negative. • Patients with negative initial prostate biopsy findings were followed up for 5 years. • The negative predictive value was 89.6% for significant prostate cancer. • MRI is a useful tool to rule out significant prostate cancer before biopsy. - Abstract: Objective: To assess the clinical negative predictive value (NPV) of multiparametric MRI (mp-MRI) for prostate cancer in a 5-year follow-up. Materials and methods: One hundred ninety-three men suspected of harboring prostate cancer with negative MRI findings were included. Patients with positive transrectal ultrasound (TRUS)-guided biopsy findings were defined as false-negative. Patients with negative initial TRUS-guided biopsy findings were followed up and only patients with negative findings by digital rectal examination, MRI, and repeat biopsy and no increase in PSA at 5-year follow-up were defined as “clinically negative”. The clinical NPV of mp-MRI was calculated. For quantitative analysis, mean signal intensity on T2-weighted images and the mean apparent diffusion coefficient value on ADC maps of the initial MRI studies were compared between peripheral-zone (PZ) cancer and the normal PZ based on pathologic maps of patients who had undergone radical prostatectomy. Results: The clinical NPV of mp-MRI was 89.6% for significant prostate cancer. Small cancers, prostatitis, and benign prostatic hypertrophy masking prostate cancer returned false-negative results. Quantitative analysis showed that there was no significant difference between PZ cancer and the normal PZ. Conclusion: The mp-MRI revealed a high clinical NPV and is a useful tool to rule out clinically significant prostate cancer before biopsy.

  10. External Beam Accelerated Partial-Breast Irradiation Using 32 Gy in 8 Twice-Daily Fractions: 5-Year Results of a Prospective Study

    Pashtan, Itai M. [Harvard Radiation Oncology Program, Boston, Massachusetts (United States); Recht, Abram [Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (United States); Ancukiewicz, Marek [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Brachtel, Elena [Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts (United States); Abi-Raad, Rita F. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); D' Alessandro, Helen A. [Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts (United States); Levy, Antonin; Wo, Jennifer Y. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Hirsch, Ariel E. [Department of Radiation Oncology, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts (United States); Kachnic, Lisa A. [Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts (United States); Goldberg, Saveli [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Specht, Michelle; Gadd, Michelle; Smith, Barbara L. [Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts (United States); Powell, Simon N. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Taghian, Alphonse G., E-mail: ataghian@partners.org [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)

    2012-11-01

    Purpose: External beam accelerated partial breast irradiation (APBI) is an increasingly popular technique for treatment of patients with early stage breast cancer following breast-conserving surgery. Here we present 5-year results of a prospective trial. Methods and Materials: From October 2003 through November 2005, 98 evaluable patients with stage I breast cancer were enrolled in the first dose step (32 Gy delivered in 8 twice-daily fractions) of a prospective, multi-institutional, dose escalation clinical trial of 3-dimensional conformal external beam APBI (3D-APBI). Median age was 61 years; median tumor size was 0.8 cm; 89% of tumors were estrogen receptor positive; 10% had a triple-negative phenotype; and 1% had a HER-2-positive subtype. Median follow-up was 71 months (range, 2-88 months; interquartile range, 64-75 months). Results: Five patients developed ipsilateral breast tumor recurrence (IBTR), for a 5-year actuarial IBTR rate of 5% (95% confidence interval [CI], 1%-10%). Three of these cases occurred in patients with triple-negative disease and 2 in non-triple-negative patients, for 5-year actuarial IBTR rates of 33% (95% CI, 0%-57%) and 2% (95% CI, 0%-6%; P<.0001), respectively. On multivariable analysis, triple-negative phenotype was the only predictor of IBTR, with borderline statistical significance after adjusting for tumor grade (P=.0537). Conclusions: Overall outcomes were excellent, particularly for patients with estrogen receptor-positive disease. Patients in this study with triple-negative breast cancer had a significantly higher IBTR rate than patients with other receptor phenotypes when treated with 3D-APBI. Larger, prospective 3D-APBI clinical trials should continue to evaluate the effect of hormone receptor phenotype on IBTR rates.

  11. External Beam Accelerated Partial-Breast Irradiation Using 32 Gy in 8 Twice-Daily Fractions: 5-Year Results of a Prospective Study

    Purpose: External beam accelerated partial breast irradiation (APBI) is an increasingly popular technique for treatment of patients with early stage breast cancer following breast-conserving surgery. Here we present 5-year results of a prospective trial. Methods and Materials: From October 2003 through November 2005, 98 evaluable patients with stage I breast cancer were enrolled in the first dose step (32 Gy delivered in 8 twice-daily fractions) of a prospective, multi-institutional, dose escalation clinical trial of 3-dimensional conformal external beam APBI (3D-APBI). Median age was 61 years; median tumor size was 0.8 cm; 89% of tumors were estrogen receptor positive; 10% had a triple-negative phenotype; and 1% had a HER-2-positive subtype. Median follow-up was 71 months (range, 2-88 months; interquartile range, 64-75 months). Results: Five patients developed ipsilateral breast tumor recurrence (IBTR), for a 5-year actuarial IBTR rate of 5% (95% confidence interval [CI], 1%-10%). Three of these cases occurred in patients with triple-negative disease and 2 in non-triple-negative patients, for 5-year actuarial IBTR rates of 33% (95% CI, 0%-57%) and 2% (95% CI, 0%-6%; P<.0001), respectively. On multivariable analysis, triple-negative phenotype was the only predictor of IBTR, with borderline statistical significance after adjusting for tumor grade (P=.0537). Conclusions: Overall outcomes were excellent, particularly for patients with estrogen receptor-positive disease. Patients in this study with triple-negative breast cancer had a significantly higher IBTR rate than patients with other receptor phenotypes when treated with 3D-APBI. Larger, prospective 3D-APBI clinical trials should continue to evaluate the effect of hormone receptor phenotype on IBTR rates.

  12. Children of Immigrants Longitudinal Study (CILS)

    Rumbaut, RG; Portes, A.

    2006-01-01

    Children of Immigrants Longitudinal Study (CILS) was designed to study the adaptation process of the immigrant second generation which is defined broadly as United States-born children with at least one foreign-born parent or children born abroad but brought at an early age to the United States. The original survey was conducted with large samples of second-generation immigrant children attending the 8th and 9th grades in public and private schools in the metropolitan areas of Miami/Ft. Laude...

  13. Early risk indicators of internalizing problems in late childhood: A 9-year longitudinal study

    Ashford, J.; Smit, H.F.E.; Van, Lier, G; Cuijpers, P.; Koot, H.M.

    2008-01-01

    Background: Longitudinal studies on risk indicators of internalizing problems in childhood are in short supply, but could be valuable to identify target groups for prevention. Methods: Standardized assessments of 294 children’s internalizing problems at the age of 2–3 years (parent report), 4–5 years (parent and teacher report) and 11 years (parent and teacher) were available in addition to risk indicators from the child, family and contextual domain. Results: Low socioeconomic status, family...

  14. Progressive changes in arch width from primary to early mixed dentition period: A longitudinal study

    S Sangwan; Chawla, H S.; Goyal, A.; Gauba, K.; Mohanty, U.

    2011-01-01

    Objective: The present study was conducted to evaluate, on a longitudinal basis, the changes in intercanine and intermolar widths form the primary to the early mixed dentition periods. Materials and Methods: A total of 38 children aged 4-5 years, with normal occlusion without any proximal caries or any dental anomalies, were selected. The impressions were recorded and casts were prepared. Intercanine and intermolar widths were measured on these dental casts with the help of a digital vernier ...

  15. A short-term longitudinal study of relational aggression and social skills of preschool children

    Isobe, Miyoshi

    2003-01-01

    This short-term longitudinal study was designed to examine relational aggression associated with social skills and anxiety-withdrawn behavior of preschool children. Relational aggression, social skills (self-control skills, friendship making skills, and assertion skills), and anxiety-withdrawn behavior of one hundred and twenty 5-year old children were assessed two times across a 6-months period by using teacher rating measures. For the data analysis, the children were divided according to th...

  16. Short-Term Longitudinal Study of Central Auditory Function in Alzheimer's Disease and Mild Cognitive Impairment

    Idrizbegovic, Esma; Hederstierna, Christina; Dahlquist, Martin; Rosenhall, Ulf

    2013-01-01

    Background/Aims Central auditory function can be studied to monitor the progression of mild cognitive impairment to dementia. Our aim was to address this issue in a prospective longitudinal setting. Methods Tests of central hearing function were performed on 70 subjects with either Alzheimer's disease (AD) or mild cognitive impairment, and in controls with subjective memory complaints but normal cognition. The time span until follow-up was 1.5 years. Results The dichotic digit free recall tes...

  17. Longitudinal study on osteoarthritis and bone metabolism

    L. Postiglione

    2011-09-01

    Full Text Available Objective: The relationship between Osteoarthritis (OA and Osteoporosis (OP is not well defined due to lacking in longitudinal data, mainly regarding correlations between biochemical factors and OA incidence. Aim of this paper was to investigate the predictive value for OA incidence of bone mass variations and of selected biochemical markers in healthy women participating in a population-based longitudinal study carried out in Naples (Italy. Subjects and Methods: High completion rate (85.2% and statistically adequate sample size were obtained: 139 women (45 to 79 years of age were examined and follow up visit was performed after two years (24±2 months, following the same protocol. Patients underwent medical examination, questionnaire, anthropometric measurements, blood sampling and urine collection. Bone mineral density (BMD measurement was performed by dual energy X-ray absorptiometry (DEXA at the lumbar spine (L1-L4 and femoral neck. Radiographs of dorsal and lumbar spine in lateral view were performed at basal and at 24 months visits; a team of three experts scored radiographs using Kellegren and Lawrence grading. Results: The score was calculated for two individual radiographic features (narrowing of the joint space, presence of osteophytes and as a global score. Results show a relevant percentage, 23% up, of subjects presenting both OA and OP. In the cross-sectional study the presence of osteophytosis correlates with anthropometric variables and PTH levels. In the longitudinal study results show a correlation between serum vitamin D and delta score for osteophytosis (β=0.02 p<0.05. Conclusions: Data obtained outline the importance of further studies on the pathogenetic link between OA and bone metabolism.

  18. DELINQUENCY PRONE YOUTH--LONGITUDINAL AND PREVENTIVE RESEARCH, EAU CLAIRE COUNTY YOUTH STUDY, PHASE III, 1965-68.

    BENNING, JAMES J.; AND OTHERS

    A FIVE-YEAR LONGITUDINAL STUDY WAS CONDUCTED OF 1550 CHILDREN, 384 OF WHOM WERE INTENSIVELY STUDIED AFTER BEING IDENTIFIED BY THEIR TEACHERS AS DEMONSTRATING SOCIALLY APPROVED OR SOCIALLY DISAPPROVED BEHAVIOR. AFTER 5 YEARS, THE SOCIALLY DISRUPTIVE GROUP OF 192 STUDENTS WAS LOWER IN ACADEMIC ACHIEVEMENT AND SOCIAL ADJUSTMENT THAN THEIR APPROVED…

  19. Code-Switching and Gender: A Longitudinal Study of Spanish/English Speaking Fraternal Boy-Girl Twins

    Robinson, Colin

    2015-01-01

    Researchers from Jean Piaget (1932) to Sehlauoi (2008) have utilized small case studies to intensively examine naturally occurring child language production in the home environment. This qualitative, 5-year longitudinal, five-year case study continues the focus of previous research on child bilingualism and code-switching; however, it aims to…

  20. Hospital Based Prospective Observational Study to Audit the Prescription Practices and Outcomes of Paediatric Patients (6 months to 5 years age group) Presenting with Acute Diarrhea

    Kondekar, Santosh; Rathi, Surbhi

    2016-01-01

    Introduction Diarrhea is a leading killer of children, accounting for 9% of all deaths among under-five children worldwide. WHO protocol deviation in management of diarrheas in children is likely due to various reasons. Aim To study the prescription practices, regarding adherence to WHO protocol and deviations, in the management of acute diarrhea in children presenting at a tertiary care hospital and its impact on the outcome. Materials and Methods This was a prospective observational hospital based study at a tertiary care carried out over a 12-month period including all cases of acute diarrhea (defined as 3 or more loose stools in last 24 hours) in children belonging to the age group of 6 months to 5 years. Patients were followed up on day 3,7,14 and 28 from the day of presentation. Software SPSS Version 17.0 was used for analysis. Correlation regression analysis was used to study predictiveness of different variables affecting outcome. Results In this study, 447 children aged between 6 months and 5 years were enrolled, of which 45 cases were lost in follow-up and excluded. The median age was 14 months. Some deviation from WHO protocol was noted in 78.4% of the cases. Most common deviations from WHO protocol were addition of probiotics (78.1% of cases) and addition of race cadotril (15.9% of cases). Inadvertent use of antibiotics in diarrhea was noted in 12.2% of cases. Presence of fever was strong predictor for use of antibiotics. Cases of early recovery within 3 days of presentation were higher in WHO protocol deviation group. Use of probiotics had statistically significant association with early recovery. Conclusion In diarrhea management, WHO protocol deviation is common. Probiotics are likely to help in early recovery. PMID:27437317

  1. Comparative study using oral solutions of bambuterol once daily or terbutaline three times daily in 2-5-year-old children with asthma. Bambuterol Multicentre Study Group.

    Kuusela, A L; Marenk, M; Sandahl, G; Sanderud, J; Nikolajev, K; Persson, B

    2000-03-01

    The aim of this study was to compare safety and efficacy of bambuterol hydrochloride (10 mg) oral solution administered once daily in the evening with terbutaline sulphate (0.075 mg/kg body weight) oral solution administered three times daily in 2-5-year-old children with asthma. There were two treatment groups: (2/3) of the patients received bambuterol and (1/3) received terbutaline. The study was double-blind, randomized, and of a parallel group design, and it lasted for 3 months after a 2-week run-in period. The primary objective was to evaluate safety (adverse events, and changes in blood pressure, pulse rate, hematology, and clinical chemistry parameters). Plasma concentrations of terbutaline and/or bambuterol were also measured. Evaluation of efficacy (diary card data) was a secondary objective. A total of 155 patients (range, 2-6 years; 3 patients were 6 years old at randomization) were treated with the study drugs; 104 patients received bambuterol and 51 patients received terbutaline. Both treatments showed a good safety profile with respect to clinical and laboratory tests, and they were generally well tolerated. Reported adverse events were mild to moderate. There were no statistically significant differences between treatment groups in any of the efficacy variables (diary variables: peak expiratory flow (PEF), asthma symptoms, restlessness, other reported symptoms, use of inhaled bronchodilators, and nighttime awakenings). For morning PEF, the mean increase from run-in to treatment was 16.9 L/min in the terbutaline group and 23.3 L/min in the bambuterol group. For evening PEF, the mean increase was 20.2 L/min in the terbutaline group and 20.6 L/min in the bambuterol group. In conclusion, once-daily bambuterol is as safe and effective as terbutaline given three times daily. The study also confirmed that bambuterol has a 24-hr duration of action, and therefore its once daily administration, makes it a preferred bronchodilator agent. Pediatr Pulmonol. 2000

  2. Colorado longitudinal twin study of reading disability.

    Wadsworth, Sally J; DeFries, John C; Olson, Richard K; Willcutt, Erik G

    2007-12-01

    The primary objectives of the present study are to introduce the Colorado Longitudinal Twin Study of Reading Disability, the first longitudinal twin study in which subjects have been specifically selected for having a history of reading difficulties, and to present some initial assessments of the stability of reading performance and cognitive abilities in this sample. Preliminary examination of the test scores of 124 twins with a history of reading difficulties and 154 twins with no history of reading difficulties indicates that over the 5- to 6-year interval between assessments, cognitive and reading performance are highly stable. As a group, those subjects with a history of reading difficulties had substantial deficits relative to control subjects on all measures at initial assessment, and significant deficits remained at follow-up. The stability noted for all cognitive and achievement measures was highest for a composite measure of reading, whose average stability correlation across groups was 0.80. Results of preliminary behavior genetic analyses for this measure indicated that shared genetic influences accounted for 86% and 49% of the phenotypic correlations between the two assessments for twin pairs with and without reading difficulties, respectively. In addition, genetic correlations reached unity for both groups, suggesting that the same genetic influences are manifested at both time points. PMID:18060583

  3. EVALUATION OF IRON STATUS IN 9-MONTH TO 5-YEAR-OLD CHILDREN WITH FEBRILE SEIZURES: A CASE-CONTROL STUDY IN THE SOUTH WEST OF IRAN

    Ali Akbar MOMEN

    2010-10-01

    Full Text Available ObjectiveFebrile convulsions are prevalent in children aged between 9 months and 5 years, with an incidence of 2-5%. On the other hand, iron deficiency anemia is the most common hematologic disease of infancy and childhood with a period of incidence that coincides with the time of developing febrile convulsions.Therefore, it is hypothesized that there is a possible association between these conditions. This study was designed to elucidate this association.Materials & MethodsTwo sex and age matched groups (n=50 in each of 9-month to 5-year-old febrile children who were admitted to Abuzar Hospital between September 2003 and October 2004 were selected. The first group, or the case group, included children with the first attack of febrile seizure and the second group, or the control group, included febrile children without seizure. Blood samples were collected for measuring complete blood count (CBC indices, serum Iron,ferritin and total iron binding capacity (TIBC levels.ResultsBoth groups were comparable for age, sex, and the type of febrile illness at admission, except for seizure. There was no significant difference in CBC, Iron and TIBC between two groups but a signicant difference was seen in MCV (Mean Corpuscular Volume, especially in females (P= 0.017. The ferritin level in the case group was significantly lower (30.3 ±16.5 µg/dl than the control group (84.2 ±28.5 µg /dl (P= 0.000.ConclusionThe findings of this study suggested a positive association between iron deficiency and the first febrile seizure in children. Supplemental iron may prevent the recurrence of febrile seizure. Prudently, further studies with larger sample sizes and longer follow-up periods need to be undertaken to substantiate this hypothesis.Keywords: Febrile seizure, Iron, ferritin level, Anemia, Children

  4. An integrated surveillance system of road traffic injuries in the Lazio region of Italy: results of a 5-year study (2001-2005).

    Chini, Francesco; Farchi, Sara; Giorgi Rossi, Paolo; Camilloni, Laura; Borgia, Piero

    2010-09-01

    Road traffic injuries represent a relevant public-health problem. In the Lazio region of Italy, a surveillance system was activated. The aim of this work is to describe the surveillance system and report the health information in terms of temporal trends for the 5-year period 2001-2005. We identified all emergency department (ED) visits in the emergency database and then linked them with hospital discharges and mortality registry. From the integrated database, we calculated the rates of emergency room visits, of hospital admissions, and of mortality, reporting the temporal trends. Between 2001 and 2005 the rate of ED visits was 3151 per 100,000 inhabitants. Hospitalisation rates showed a significant decreasing trend. The surveillance identified 22% more deaths in the study period than reported by the official statistics. The surveillance revealed a decreasing trend for hospital admissions and a decline in deaths in 2003 concurrent to the introduction of the driver's licence point system. PMID:20352552

  5. Working conditions, health and productivity among dentists in Swedish public dental care - a prospective study during a 5-year period of rationalisation

    Rolander, B.; Jonker, D.; Winkel, Jørgen;

    2013-01-01

    In recent decades, comprehensive rationalisations have been implemented in public dentistry in Sweden. How rationalisations affect working conditions, health and production from a long-term perspective has been poorly investigated. This study aims to analyse changes and associations in dentists......' working conditions, health and productivity during a 5-year period. In 2003 and 2008, 65 dentists responded to questionnaires measuring work conditions and health. Treatment times for patients and productivity were tracked in electronic registers. Paired t-tests showed that the number of treated adult...... patients per dentist increased, and perceived physical working conditions improved while perceived work control and leadership deteriorated. Structural equation modelling showed that physical factors were important for health and productivity. When assessing risks in the work environment, there is a need...

  6. Rates and predictors of remission, recurrence and conversion to bipolar disorder after the first lifetime episode of depression - a prospective 5-year follow-up study

    Bukh, Jens Drachmann; Andersen, P K; Kessing, L V

    2016-01-01

    and 8.6% converted to bipolar disorder (6.3% within the first 2 years). Non-remission increased with younger age, co-morbid anxiety and suicidal ideations. Recurrence increased with severity and treatment resistance of the first depression, and conversion to bipolar disorder with treatment resistance......BACKGROUND: In depression, non-remission, recurrence of depressive episodes after remission and conversion to bipolar disorder are crucial determinants of poor outcome. The present study aimed to determine the cumulative incidences and clinical predictors of these long-term outcomes after the first...... lifetime episode of depression. METHOD: A total of 301 in- or out-patients aged 18-70 years with a validated diagnosis of a single depressive episode were assessed from 2005 to 2007. At 5 years of follow-up, 262 patients were reassessed by means of the life chart method and diagnostic interviews from 2011...

  7. A retrospective study of 5-year outcomes of radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma refractory to Helicobacter pylori eradication therapy

    The favorable response rate of radiotherapy for localized gastric mucosa-associated lymphoid tissue lymphoma refractory to Helicobacter pylori eradication has been demonstrated. However, there are limited data available on the long-term outcomes. The aim of this retrospective study was to evaluate the long-term outcomes of radiotherapy for localized gastric mucosa-associated lymphoid tissue lymphoma refractory to Helicobacter pylori eradication. Thirty-four consecutive patients with localized gastric mucosa-associated lymphoid tissue lymphoma that were refractory to eradication were treated with radiotherapy (a total dose of 30 Gy). The response and adverse events of radiotherapy were retrospectively analyzed as short-term outcomes, and recurrence-free, overall and disease-specific survival rates were calculated as long-term outcomes. Thirty-three (97.1%) patients achieved complete remission and radiotherapy was well tolerated. One patient underwent emergency gastrectomy due to severe hematemesis. Of the 34 patients during the median follow-up period of 7.5 (1.2-13.0) years, one patient had local recurrence after 8.8 years, one patient underwent surgery for bowel obstruction secondary to small bowel metastasis after 5.1 years and one patient had pulmonary metastasis after 10.9 years. Pathologically, all three recurrences revealed mucosa-associated lymphoid tissue lymphoma without any transformation to high-grade lymphoma. None died of gastric mucosa-associated lymphoid tissue lymphoma. The 5-year recurrence-free survival rate was 97.0%. The 5-year overall survival rates and disease-specific survival rates were 97.0 and 100%, respectively. Radiotherapy in patients with localized gastric mucosa-associated lymphoid tissue lymphoma refractory to Helicobacter pylori eradication can achieve excellent overall survival. However, long-term surveillance is necessary to identify late recurrences. (author)

  8. Psychosocial adjustment to ALS: a longitudinal study

    Tamara eMatuz

    2015-09-01

    Full Text Available For the current study the Lazarian stress-coping theory and the appendant model of psychosocial adjustment to chronic illness and disabilities (Pakenham 1999 has shaped the foundation for identifying determinants of adjustment to ALS. We aimed to investigate the evolution of psychosocial adjustment to ALS and to determine its long-term predictors. A longitudinal study design with four measurement time points was therefore, used to assess patients’ quality of life, depression, and stress-coping model related aspects, such as illness characteristics, social support, cognitive appraisals and coping strategies during a period of two years. Regression analyses revealed that 55% of the variance of severity of depressive symptoms and 47% of the variance in quality of life at T2 was accounted for by all the T1 predictor variables taken together. On the level of individual contributions, protective buffering and appraisal of own coping potential accounted for a significant percentage in the variance in severity of depressive symptoms, whereas problem management coping strategies explained variance in quality of life scores. Illness characteristics at T2 did not explain any variance of both adjustment outcomes. Overall, the pattern of the longitudinal results indicated stable depressive symptoms and quality of life indices reflecting a successful adjustment to the disease across four measurement time points during a period of about two years.Empirical evidence is provided for the predictive value of social support, cognitive appraisals, and coping strategies, but not illness parameters such as severity and duration for adaptation to ALS. The current study contributes to a better conceptualization of adjustment, allowing us to provide evidence-based support beyond medical and physical intervention for people with ALS.

  9. Self-Reported Periodontitis and Incident Type 2 Diabetes among Male Workers from a 5-Year Follow-Up to MY Health Up Study

    Miyawaki, Atsushi; Toyokawa, Satoshi; Inoue, Kazuo; Miyoshi, Yuji; Kobayashi, Yasuki

    2016-01-01

    Aims The purpose of this study was to examine whether periodontitis is associated with incident type 2 diabetes in a Japanese male worker cohort. Methods The study participants were Japanese men, aged 36–55 years, without diabetes. Data were extracted from the MY Health Up study, consisting of self-administered questionnaire surveys at baseline and following annual health examinations for an insurance company in Japan. The oral health status of the participants was classified by two self-reported indicators: (1) gingival hemorrhage and (2) tooth loosening. Type 2 diabetes incidence was determined by self-reporting or blood test data. Modified Poisson regression approach was used to estimate the relative risks and the 95% confidence intervals of incident diabetes with periodontitis. Covariates included age, body mass index, family history of diabetes, hypertension, current smoking habits, alcohol use, dyslipidemia, and exercise habits. Results Of the 2895 candidates identified at baseline in 2004, 2469 men were eligible for follow-up analysis, 133 of whom were diagnosed with diabetes during the 5-year follow-up period. Tooth loosening was associated with incident diabetes [adjusted relative risk = 1.73, 95% confidence interval = 1.14–2.64] after adjusting for other confounding factors. Gingival hemorrhage displayed a similar trend but was not significantly associated with incident diabetes [adjusted relative risk = 1.32, 95% confidence interval = 0.95–1.85]. Conclusions Tooth loosening is an independent predictor of incident type 2 diabetes in Japanese men. PMID:27115749

  10. The economic impact of surgically treated peri-prosthetic hip fractures on a university teaching hospital in Wales 7.5-year study.

    Jones, Andrew R; Williams, Tim; Paringe, Vishal; White, Simon P

    2016-02-01

    The number of total hip replacements taking place across the UK continues to grow. In an ageing population, with people placing greater demands on their prostheses, the number of peri-prosthetic fractures is increasing. We studied the economic impact this has on a large teaching hospital. All patients with peri-prosthetic femoral fracture in a 7.5 year period were identified. Radiographic and case note analysis was performed. Costings from the finance departments were obtained. 90 cases were identified, 58 female and 32 male, with a mean age of 76 (range: 38-91). 89 of the cases were managed surgically, 66% undergoing revision and 33% receiving open reduction and internal fixation. According to the Vancouver Classification, 3% were Type A, 79% Type B and 18% Type C. The mean length of stay was 43 days. The mean cost of management was £31,370 (range: £6885-£112,327). Patients with type C fractures had the highest mean length of stay at 53 days and mean cost of £33,417. Including rehabilitation costs, our study illustrated a mean cost of £31,370, roughly four times the current basic NHS tariff of £8552. Although implant costs are greater, treatment with revision where appropriate allows earlier weight bearing, reduced length of stay and lower overall cost. PMID:26689495

  11. Risk factors for death among children less than 5 years old hospitalized with diarrhea in rural western Kenya, 2005-2007: a cohort study.

    Ciara E O'Reilly

    Full Text Available BACKGROUND: Diarrhea is a leading cause of childhood morbidity and mortality in sub-Saharan Africa. Data on risk factors for mortality are limited. We conducted hospital-based surveillance to characterize the etiology of diarrhea and identify risk factors for death among children hospitalized with diarrhea in rural western Kenya. METHODS AND FINDINGS: We enrolled all children <5 years old, hospitalized with diarrhea (≥3 loose stools in 24 hours at two district hospitals in Nyanza Province, western Kenya. Clinical and demographic information was collected. Stool specimens were tested for bacterial and viral pathogens. Bivariate and multivariable logistic regression analyses were carried out to identify risk factors for death. From May 23, 2005 to May 22, 2007, 1,146 children <5 years old were enrolled; 107 (9% children died during hospitalization. Nontyphoidal Salmonella were identified in 10% (118, Campylobacter in 5% (57, and Shigella in 4% (42 of 1,137 stool samples; rotavirus was detected in 19% (196 of 1,021 stool samples. Among stools from children who died, nontyphoidal Salmonella were detected in 22%, Shigella in 11%, rotavirus in 9%, Campylobacter in 5%, and S. Typhi in <1%. In multivariable analysis, infants who died were more likely to have nontyphoidal Salmonella (adjusted odds ratio [aOR] = 6·8; 95% CI 3·1-14·9, and children <5 years to have Shigella (aOR = 5·5; 95% CI 2·2-14·0 identified than children who survived. Children who died were less likely to be infected with rotavirus (OR = 0·4; 95% CI 0·2-0·8. Further risk factors for death included being malnourished (aOR = 4·2; 95% CI 2·1-8·7; having oral thrush on physical exam (aOR = 2·3; 95% CI 1·4-3·8; having previously sought care at a hospital for the illness (aOR = 2·2; 95% CI 1·2-3·8; and being dehydrated as diagnosed at discharge/death (aOR = 2·5; 95% CI 1·5-4·1. A clinical diagnosis of malaria, and malaria parasites seen on

  12. Risk Factors for Long-Term Mortality after Hospitalization for Community-Acquired Pneumonia: A 5-Year Prospective Follow-Up Study

    Holter, Jan C.; Ueland, Thor; Jenum, Pål A.; Müller, Fredrik; Brunborg, Cathrine; Frøland, Stig S.; Aukrust, Pål; Husebye, Einar; Heggelund, Lars

    2016-01-01

    Background Contributors to long-term mortality in patients with community-acquired pneumonia (CAP) remain unclear, with little attention paid to pneumonia etiology. We examined long-term survival, causes of death, and risk factors for long-term mortality in adult patients who had been hospitalized for CAP, with emphasis on demographic, clinical, laboratory, and microbiological characteristics. Methods Two hundred and sixty-seven consecutive patients admitted in 2008–2011 to a general hospital with CAP were prospectively recruited and followed up. Patients who died during hospital stay were excluded. Demographic, clinical, and laboratory data were collected within 48 hours of admission. Extensive microbiological work-up was performed to establish the etiology of CAP in 63% of patients. Mortality data were obtained from the Norwegian Cause of Death Registry. Cox regression models were used to identify independent risk factors for all-cause mortality. Results Of 259 hospital survivors of CAP (median age 66 years), 79 (30.5%) died over a median of 1,804 days (range 1–2,520 days). Cumulative 5-year survival rate was 72.9% (95% CI 67.4–78.4%). Standardized mortality ratio was 2.90 for men and 2.05 for women. The main causes of death were chronic obstructive pulmonary disease (COPD), vascular diseases, and malignancy. Independent risk factors for death were the following (hazard ratio, 95% CI): age (1.83 per decade, 1.47–2.28), cardiovascular disease (2.63, 1.61–4.32), COPD (2.09, 1.27–3.45), immunocompromization (1.98, 1.17–3.37), and low serum albumin level at admission (0.75 per 5g/L higher, 0.58–0.96), whereas active smoking was protective (0.32, 0.14–0.74); active smokers were younger than non-smokers (P < 0.001). Microbial etiology did not predict mortality. Conclusions Results largely confirm substantial comorbidity-related 5-year mortality after hospitalization for CAP and the impact of several well-known risk factors for death, and extend

  13. Longitudinal study of leptin levels in chronic hemodialysis patients

    Averbukh Zhan

    2011-06-01

    Full Text Available Abstract Background The influence of serum leptin levels on nutritional status and survival in chronic hemodialysis patients remained to be elucidated. We conducted a prospective longitudinal study of leptin levels and nutritional parameters to determine whether changes of serum leptin levels modify nutritional status and survival in a cohort of prevalent hemodialysis patients. Methods Leptin, dietary energy and protein intake, biochemical markers of nutrition and body composition (anthropometry and bioimpedance analysis were measured at baseline and at 6, 12, 18 and 24 months following enrollment, in 101 prevalent hemodialysis patients (37% women with a mean age of 64.6 ± 11.5 years. Observation of this cohort was continued over 2 additional years. Changes in repeated measures were evaluated, with adjustment for baseline differences in demographic and clinical parameters. Results Significant reduction of leptin levels with time were observed (linear estimate: -2.5010 ± 0.57 ng/ml/2y; p Conclusions Thus leptin levels reflect fat mass depots, rather than independently contributing to uremic anorexia or modifying nutritional status and/or survival in chronic hemodialysis patients. The importance of such information is high if leptin is contemplated as a potential therapeutic target in hemodialysis patients.

  14. Increasing incidence of Clostridium difficile infections: results from a 5-year retrospective study in a large teaching hospital in the Italian region with the oldest population.

    Alicino, C; Giacobbe, D R; Durando, P; Bellina, D; DI Bella, A M; Paganino, C; Del Bono, V; Viscoli, C; Icardi, G; Orsi, A

    2016-09-01

    Limited information is available on the incidence of Clostridium difficile infections (CDIs) in Italian hospitals. In this study, we assessed the changes in the incidence of CDI over a 5-year period in a teaching hospital in Liguria, the Italian region with the oldest population. Secondary endpoints were the development of severe CDI and 30-day mortality. The annual incidence of CDI/10000 patient-days significantly increased from 0·54 in 2010 to 3·04 in 2014 (χ 2 for trend, P < 0·001). The median age of patients with CDI was 81 years. As many as 81% and 89% of these patients had comorbid conditions and previous exposure to antibiotics, respectively. In the multivariate analysis of risk factors for severe CDI, previous therapy with histamine 2 blockers and low serum albumin were associated with severe CDI, while diabetes appeared to be protective. In the multivariate model of risk factors for 30-day mortality, high leukocyte count, low serum albumin, and increased serum creatinine were unfavourably associated with outcome. Strict adherence to infection control measures was of utmost importance to counteract the increasing incidence of CDI in our hospital, particularly because of the advanced age of the patients and their very high frequency of chronic conditions and use of antibiotics, which readily predispose them to the development of CDI. PMID:27193828

  15. TAILOR THE LONGITUDINAL ANAYSIS FOR NIH LONGITUDINAL NORMAL BRAIN DEVELOPMENTAL STUDY

    Chen, Yasheng; An, Hongyu; Shen, Dinggang; Zhu, Hongtu; Lin, Weili

    2014-01-01

    There are imminent needs for longitudinal analysis to make physiological inferences on NIH MRI study of normal brain development. But up to date, two critical aspects for longitudinal analysis, namely the selections of mean and covariance structures have not been addressed by the neuroimaging community. For the mean structure, we employed a linear free-knot B-spline regression in combination with quasi-least square estimating equations to approximate a nonlinear growth trajectory with piecewi...

  16. Changes in bone mineral density (BMD) around the cemented Exeter stem: a prospective study in 18 women with 5 years follow-up

    Damborg, Frank; Nissen, Nis; Jørgensen, Hans R I;

    2008-01-01

    BACKGROUND AND PURPOSE: THA changes the pattern of strain distribution in the proximal femur. We quantified the changes in BMD for 5 years after insertion of the cemented Exeter stem in women. METHODS: 18 women aged 55-79 years, undergoing unilateral THA with the cemented Exeter stem, were included...

  17. Early Predictors of Adolescent Depression: A 7-Year Longitudinal Study

    Mazza, James J.; Abbott, Robert D.; Fleming, Charles B.; Harachi, Tracy W.; Cortes, Rebecca C.; Park, Jisuk; Haggerty, Kevin P.; Catalano, Richard F.

    2009-01-01

    This study examined the longitudinal relationship of early elementary predictors to adolescent depression 7 years later. The sample consisted of 938 students who have been part of a larger longitudinal study that started in 1993. Data collected from parents, teachers, and youth self-reports on early risk factors when students were in 1st and 2nd…

  18. 精神病人自杀行为的随访研究%A 5-year follow-up study of suicide attempts

    周建初; 邓永清; 张德源

    2001-01-01

    Objective This was a follow-up study of suicidal patients to assess the influence over time of different risk factors.Method A cohort of 73 patients admitted to a psychiatric department after a suicide attempt was followed-up for 5 years.Results In total,61.6% reattemped,15.1% of which had committed suicide during the follow-up.The rist factors for suicide included history of family psychiatric or suicide,and a poor social support,et al.Conclusion The results suggest a high repetition rate of suicide attempters in the psychotic patients who had previous suicidal behaviour and them positive family history.The preventive strategy to suicide in patients,such as set up good social network and should pay mroe attention to psyciologic rehabilitation period after discharge.%目的探讨精神病人自杀行为的危险因素。方法对73例有自杀行为的精神病人出院后进行5年跟踪随访研究。结果出院后5年内有61.6%的病人再次出现自杀行为,其中15.1%的病人自杀身亡。再次出现自杀的因素有阳性家族史、社会支持状态较差等。结论有精神病和自杀家族史且有自杀行为者再次发生自杀的机率较大,病人出院后的心理康复治疗和建立良好的社会环境是防止自杀的重要措施。

  19. Prevalence and cumulative incidence of abnormal cervical cytology among HIV-infected Thai women: a 5.5-year retrospective cohort study

    Thamkhantho Manopchai

    2011-01-01

    Full Text Available Abstract Background Cervical cancer is one of the most common AIDS-related malignancies in Thailand. To prevent cervical cancer, The US Public Health Service and The Infectious Disease Society of America have recommended that all HIV-infected women should obtain 2 Pap smears 6 months apart after the initial HIV diagnosis and, if results of both are normal, should undergo annual cytological screening. However, there has been no evidence in supporting whether this guideline is appropriate in all settings - especially in areas where HIV-infected women are living in resource-constrained condition. Methods To determine the appropriate interval of Pap smear screenings for HIV-infected Thai women and risk factors for subsequent abnormal cervical cytology, we assessed the prevalence, cumulative incidence and associated factors of cervical cell abnormalities (atypical squamous cell of undetermined significance or higher grades, ASCUS+ among this group of patients. Results The prevalence of ASCUS+ was 15.4% at the first visit, and the cumulative incidence of ASCUS+ gradually increased to 37% in the first 3.5 years of follow-up appointments (first 7 times, and tended to plateau in the last 2 years. For multivariate correlation analysis, women with a CD4 count P = 0.043. There were no associations of subsequent ASCUS+ with age, pregnancy, contraceptive method, highly active anti-retroviral treatment, assumed duration of infection, or the CD4 count nadir level. Conclusion There are high prevalence and cumulative incidence of ASCUS+ in HIV-infected Thai women. With a high lost-to-follow-up rate, an appropriate interval of Pap smear screening cannot be concluded from the present study. Nevertheless, the HIV-infected Thai women may require more than two normal semi-annual Pap smears before shifting to routinely annual cytologic screening.

  20. Net global warming potential and greenhouse gas intensity in rice agriculture driven by high yields and nitrogen use efficiency: a 5 year field study

    Zhang, X.; Zhou, Z.; Liu, Y.; Xu, X.; Wang, J.; Zhang, H.; Xiong, Z.

    2015-11-01

    Our understanding of how net global warming potential (NGWP) and greenhouse gas intensity (GHGI) is affected by management practices aimed at food security with respect to rice agriculture remains limited. In the present study, a 5 year field experiment was conducted in China to evaluate the effects of integrated soil-crop system management (ISSM) on NGWP and GHGI after accounting for carbon dioxide (CO2) emissions from all sources (methane, CH4, and nitrous oxide, N2O, emissions, agrochemical inputs, Ei, and farm operations, Eo) and sinks (i.e., soil organic carbon, SOC, sequestration). For the improvement of rice yield and agronomic nitrogen use efficiency (NUE), four ISSM scenarios consisting of different nitrogen (N) fertilization rates relative to the local farmers' practice (FP) rate were carried out, namely, N1 (25 % reduction), N2 (10 % reduction), N3 (FP rate) and N4 (25 % increase). The results showed that compared with the FP, the four ISSM scenarios, i.e., N1, N2, N3 and N4, significantly increased the rice yields by 10, 16, 28 and 41 % and the agronomic NUE by 75, 67, 86 and 82 %, respectively. In addition, compared with the FP, the N1 and N2 scenarios significantly reduced the GHGI by 14 and 18 %, respectively, despite similar NGWPs. The N3 and N4 scenarios remarkably increased the NGWP and GHGI by an average of 67 and 36 %, respectively. In conclusion, the ISSM strategies are promising for both food security and environmental protection, and the ISSM scenario of N2 is the optimal strategy to realize high yields and high NUE together with low environmental impacts for this agricultural rice field.

  1. Factors Affecting Access to Healthcare: An Observational Study of Children under 5 Years of Age Presenting to a Rural Gambian Primary Healthcare Centre

    Hawkesworth, Sophie; Moore, Sophie E.; Dondeh, Bai L.; Unger, Stefan A.

    2016-01-01

    Main Objective Prompt access to primary healthcare before onset of severe illness is vital to improve morbidity and mortality rates. The Gambia has high rates of child mortality and research is needed to investigate contributing factors further. This study aimed to identify factors affecting access to primary healthcare for children <5 years (y) in rural Gambia focusing on delayed presentation and severe illness at presentation as indicators in a setting where primary healthcare is delivered free of charge. Methods Data were extracted from an electronic medical records system at a rural primary healthcare clinic in The Gambia for children (0–5y) between 2009 and 2012. First clinic attendances with malaria, lower respiratory tract infections (LRTI) and diarrhoeal disease, the main contributors to mortality in this setting, were identified and categorized as delayed/non-delayed and severe/non-severe representing our two main outcome measures. Potential explanatory variables, identified through a comprehensive literature review were obtained from an ongoing demographic surveillance system for this population. Variables associated with either delayed/non-delayed and/or with severe/non-severe presentations identified by univariate analysis (p<0.1) were assessed in multivariate models using logistic regression (p<0.05). Results Out of 6554 clinic attendances, 571 relevant attendances were identified. Delayed presentation was common (45% of all presentations) and there was a significantly reduced risk associated with being from villages with free regular access to transport (OR 0.502, 95%CI[0.310, 0.814], p = 0.005). Children from villages with free regular transport were also less likely to present with severe illness (OR 0.557, 95%CI[0.325, 0.954], p = 0.033). Conclusions Transport availability rather than distance to health clinic is an important barrier to accessing healthcare for children in The Gambia, and public health interventions should aim to reduce this

  2. Longitudinal morphometric MRI study of Alzheimer's disease

    A longitudinal morphometric MRI study of Alzheimer's disease (AD) was conducted to determine the relationship between the progression of the symptoms and the progression of the brain atrophy. The Voxel-based Specific Regional Analysis System for Alzheimer's Disease (VSRAD), developed by Matsuda et al. was used as a method of morphometry to perform the statistical MR image analysis. Thirty-eight patients of AD patients were investigated with VSRAD. These patients were divided into two groups according to the progression of symptoms based on a clinical evaluation. One group was the progress group (20 patients), while the other group was the stable group (18 patients) for comparison. The relationship was investigated between the speed of the symptomatic progression and the change in each VSRAD indicator. Consequently, the entorhinal Z-score and the entorhinal atrophy rate showed a correlation with the speed of the symptomatic progression. The increase of the entorhinal Z-score in the follow-up was larger in the progress group than that in the stable group (0.65/1.28 years in the progress group and 0.05/1.26 years in the stable group.). These results suggest that a rapid symptomatic progression in an AD patient accompanies the rapid progression of atrophy in the entorhinal cortex. (author)

  3. NASA Planetary Science Summer School: Longitudinal Study

    Giron, Jennie M.; Sohus, A.

    2006-12-01

    NASA’s Planetary Science Summer School is a program designed to prepare the next generation of scientists and engineers to participate in future missions of solar system exploration. The opportunity is advertised to science and engineering post-doctoral and graduate students with a strong interest in careers in planetary exploration. Preference is given to U.S. citizens. The “school” consists of a one-week intensive team exercise learning the process of developing a robotic mission concept into reality through concurrent engineering, working with JPL’s Advanced Project Design Team (Team X). This program benefits the students by providing them with skills, knowledge and the experience of collaborating with a concept mission design. A longitudinal study was conducted to assess the impact of the program on the past participants of the program. Data collected included their current contact information, if they are currently part of the planetary exploration community, if participation in the program contributed to any career choices, if the program benefited their career paths, etc. Approximately 37% of 250 past participants responded to the online survey. Of these, 83% indicated that they are actively involved in planetary exploration or aerospace in general; 78% said they had been able to apply what they learned in the program to their current job or professional career; 100% said they would recommend this program to a colleague.

  4. Assessment of the effect of iris colour and having children on 5-year risk of death after diagnosis of uveal melanoma: a follow-up study

    Schmidt-Pokrzywniak, Andrea; Kalbitz, Sven; Kuss, Oliver; Jöckel, Karl-Heinz; Bornfeld, Norbert; Stang, Andreas

    2014-01-01

    Background To examine the all-cause mortality and uveal melanoma specific mortality among newly diagnosed uveal melanoma patients after five years. Furthermore, we assess of the effect of iris colour and having children on 5-year risk of death after diagnosis of uveal melanoma. Therefore, we assess the performance of an individual prediction model of survival from uveal melanoma. Methods A cohort of 459 patients aged 45 to 79 years with newly diagnosed uveal melanoma was recruited between 200...

  5. Risk Factors for Death among Children Less than 5 Years Old Hospitalized with Diarrhea in Rural Western Kenya, 2005–2007: A Cohort Study

    O'Reilly, Ciara E.; Jaron, Peter; Ochieng, Benjamin; Nyaguara, Amek; Tate, Jacqueline E; Parsons, Michele B.; Bopp, Cheryl A.; Williams, Kara A.; Vinjé, Jan; Blanton, Elizabeth; Wannemuehler, Kathleen A.; Vulule, John; Kayla F. Laserson; Breiman, Robert F.; Feikin, Daniel R.

    2012-01-01

    Editors' Summary Background Diarrhea—passing three or more loose or liquid stools per day—kills about 1.5 million young children every year, mainly in low- and middle-income countries. Globally, it is the second leading cause of death in under-5-year olds, causing nearly one in five child deaths. Diarrhea, which can lead to life-threatening dehydration, is a common symptom of gastrointestinal infections. The pathogens (viruses, bacteria, and parasites) that cause diarrhea spread through conta...

  6. Etiology and Factors Associated with Pneumonia in Children under 5 Years of Age in Mali: A Prospective Case-Control Study.

    Thomas Bénet

    Full Text Available There are very limited data on children with pneumonia in Mali. The objective was to assess the etiology and factors associated with community-acquired pneumonia in hospitalized children <5 years of age in Mali.A prospective hospital-based case-control study was implemented in the Pediatric department of Gabriel Touré University Hospital at Bamako, Mali, between July 2011-December 2012. Cases were children with radiologically-confirmed pneumonia; Controls were hospitalized children without respiratory features, matched for age and period. Respiratory specimens, were collected to identify 19 viruses and 5 bacteria. Whole blood was collected from cases only. Factors associated with pneumonia were assessed by multivariate logistic regression.Overall, 118 cases and 98 controls were analyzed; 44.1% were female, median age was 11 months. Among pneumonia cases, 30.5% were hypoxemic at admission, mortality was 4.2%. Pneumonia cases differed from the controls regarding clinical signs and symptoms but not in terms of past medical history. Multivariate analysis of nasal swab findings disclosed that S. pneumoniae (adjusted odds ratio [aOR] = 3.4, 95% confidence interval [95% CI]: 1.6-7.0, human metapneumovirus (aOR = 17.2, 95% CI: 2.0-151.4, respiratory syncytial virus [RSV] (aOR = 7.4, 95% CI: 2.3-23.3, and influenza A virus (aOR = 10.7, 95% CI: 1.0-112.2 were associated with pneumonia, independently of patient age, gender, period, and other pathogens. Distribution of S. pneumoniae and RSV differed by season with higher rates of S. pneumoniae in January-June and of RSV in July-September. Pneumococcal serotypes 1 and 5 were more frequent in pneumonia cases than in the controls (P = 0.009, and P = 0.04, respectively.In this non-PCV population from Mali, pneumonia in children was mainly attributed to S. pneumoniae, RSV, human metapneumovirus, and influenza A virus. Increased pneumococcal conjugate vaccine coverage in children could significantly reduce the

  7. Early Developmental Assessment of Children with Major Non-Cardiac Congenital Anomalies Predicts Development at the Age of 5 Years

    Mazer, Petra; Gischler, Saskia J.; van der Cammen-van Zijp, Monique H. M.; Tibboel, Dick; Bax, Nicolaas M. A.; Ijsselstijn, Hanneke; van Dijk, Monique; Duivenvoorden, Hugo J.

    2010-01-01

    Aim: The aim of this study was to evaluate cognitive and motor development in children with major congenital anomalies and the predictability of development at age 5 years. Method: A prospective, longitudinal follow-up study was undertaken. The Dutch version of the Bayley Scales of Infant Development--Mental Developmental Index (MDI) and…

  8. Practice and drop-out effects during a 17-year longitudinal study of cognitive aging.

    Rabbitt, Patrick; Diggle, Peter; Holland, Fiona; McInnes, Lynn

    2004-03-01

    Interpretations of longitudinal studies of cognitive aging are misleading unless effects of practice and selective drop-out are considered. A random effects model taking practice and drop-out into account analyzed data from four successive presentations of each of two intelligence tests, two vocabulary tests, and two verbal memory tests during a 17-year longitudinal study of 5,899 community residents whose ages ranged from 49 to 92 years. On intelligence tests, substantial practice effects counteracted true declines observed over 3 to 5 years of aging and remained significant even with intervals of 7 years between successive assessments. Adjustment for practice and drop-out revealed accelerating declines in fluid intelligence and cumulative learning, linear declines in verbal free recall, and no substantial change in vocabulary. Socioeconomic status and basal levels of general fluid ability did not affect rates of decline. After further adjustment for demographics, variability between individuals was seen to increase as the sample aged. PMID:15014091

  9. PREVENTION OF PARENT TO CHILD TRANSMISSION OF HIV : A RETROSPECTIVE STUDY OF 5 YEARS IN A TERTIARY CENTRE , GUNTUR, SOUTH INDIA

    Potharaju

    2015-02-01

    Full Text Available OBJECTIVE: Mother to child transmission of HIV is a major route of HIV infection in children. The objective of this study is to analyze the response to implementation of PPTCT programme, the response of the spouses of the seropositive antenatal women to undergo HIV testing, mode of delivery and breast feeding practices adopted by the ser o positive postnatal women and the status of infants after delivery at 18 months. METHODS : This retrospective study was done in the Department Of Obstetrics and Gynecology, Guntur Medical College, Guntur, A.P, India and data collected from April 2009 to march 2014, a period of 5 years was studied. PPTCT centre was established in our institution in 2003. The practice in our institution is that all pregnant women attending the Antenatal clinic or Labour Room are counseled for HIV testing, and tested as per NACO guidelines. Babies born to HIV s e ropositive women are followed up to 18 months for confirmatory testing. RESULTS : The number of antenatal women counseled who opted for HIV testing were 99.4% and women who tested seropositive was 1.6 %, 1.3%, 0.9%, 0.84%, 0.6% for the years 2009 - 10, 10 - 11, 11 - 12, 12 - 13, 13 - 14 respectively showing a declining trend in the prevalence of HIV in antenatal women. 94.6% of women attended the post - test counseling . Spouses of ser o positive antenatal women who opted for testing was 52.5% and seropositivity in the spouses tested was 65.87% during the study period. Of the 767 seropositive women who delivered, 542(70.66% had vaginal delivery 225(29.33% had LSCS for obstetric indication. Of the 767 seropositive women who delivered 719(93.7% had live births, 28(3.65% had intrauterine fetal demise and 20(2.6% newborns died in the perinatal period. The number of seropositive women opting for exclusive replacement feeding was 54.4% during the study period April 2009 to March 2014. Confirmatory test for infants was done at 18 months and of the 136 infants tested, 14 were

  10. Causal Inference from Longitudinal Studies with Baseline Randomization

    2008-01-01

    We describe analytic approaches for study designs that, like large simple trials, can be better characterized as longitudinal studies with baseline randomization than as either a pure randomized experiment or a purely observational study. We (i) discuss the intention-to-treat effect as an effect measure for randomized studies, (ii) provide a formal definition of causal effect for longitudinal studies, (iii) describe several methods -- based on inverse probability weighting and g-estimation --...

  11. 78 FR 44553 - Agency Information Collection Activities; Comment Request; Early Childhood Longitudinal Study...

    2013-07-24

    ... Agency Information Collection Activities; Comment Request; Early Childhood Longitudinal Study... notice will be considered public records. Title of Collection: Early Childhood Longitudinal Study... sister study, the Early Childhood Longitudinal Study, Kindergarten Class of 1998-99 (ECLS-K), the...

  12. Spatial distribution of the persistent organic pollutants across the Tibetan Plateau and its linkage with the climate systems: a 5-year air monitoring study

    Wang, Xiaoping; Ren, Jiao; Gong, Ping; Wang, Chuanfei; Xue, Yonggang; Yao, Tandong; Lohmann, Rainer

    2016-06-01

    The Tibetan Plateau (TP) has been contaminated by persistent organic pollutants (POPs), including legacy organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) through atmospheric transport. The exact source regions, transport pathways and time trends of POPs to the TP are not well understood. Here polystyrene-divinylbenzene copolymer resin (XAD)-based passive air samplers (PASs) were deployed at 16 Tibetan background sites from 2007 to 2012 to gain further insight into spatial patterns and temporal trends of OCPs and PCBs. The southeastern TP was characterized by dichlorodiphenyltrichloroethane (DDT)-related chemicals delivered by Indian monsoon air masses. The northern and northwestern TP displayed the greatest absolute concentration and relative abundance of hexachlorobenzene (HCB) in the atmosphere, caused by the westerly-driven European air masses. The interactions between the DDT polluted Indian monsoon air and the clean westerly winds formed a transition zone in central Tibet, where both DDT and HCB were the dominant chemicals. Based on 5 years of continuous sampling, our data indicated declining concentrations of HCB and hexachlorocyclohexanes (HCHs) across the Tibetan region. Inter-annual trends of DDT class chemicals, however, showed less variation during this 5-year sampling period, which may be due to the ongoing usage of DDT in India. This paper demonstrates the possibility of using POP fingerprints to investigate the climate interactions and the validity of using PAS to derive inter-annual atmospheric POP time trends.

  13. Study protocol: the JEU cohort study – transversal multiaxial evaluation and 5-year follow-up of a cohort of French gamblers

    Challet-Bouju, Gaëlle; Hardouin, Jean-Benoit; Vénisse, Jean-Luc; Romo, Lucia; Valleur, Marc; Magalon, David; Fatséas, Mélina; Chéreau-Boudet, Isabelle; Gorsane, Mohamed-Ali; . .; Grall-Bronnec, Marie

    2014-01-01

    Background There is abundant literature on how to distinguish problem gambling (PG) from social gambling, but there are very few studies of the long-term evolution of gambling practice. As a consequence, the correlates of key state changes in the gambling trajectory are still unknown. The objective of the JEU cohort study is to identify the determinants of key state changes in the gambling practice, such as the emergence of a gambling problem, natural recovery from a gambling problem, resolut...

  14. Allergies and major depression: a longitudinal community study

    Lavorato Dina H; Williams Jeanne VA; Patten Scott B; Eliasziw Michael

    2009-01-01

    Abstract Background Cross-sectional studies have reported associations between allergies and major depression but in the absence of longitudinal data, the implications of this association remain unclear. Our goal was to examine this association from a longitudinal perspective. Methods The data source was the Canadian National Population Health Survey (NPHS). This study included a short form version of the Composite International Diagnostic Interview (CIDI-SF) to assess major depression and al...

  15. Gender differences in postpartum depression. A longitudinal cohort study

    Escribà-Agüir, Vicenta; Artazcoz, Lucía

    2010-01-01

    Abstract Background: The course of depression from pregnancy to one year postpartum and their risk factors among mothers and fathers are not known. This study has two aims: 1) To report the longitudinal patterns of depression from third trimester of pregnancy to one year after childbirth and 2) to determine gender differences between women and their partners in the effect of psychosocial and personal factors on postpartum depression. Methods: A longitudinal cohort study was carr...

  16. Do television and electronic games predict children's psychosocial adjustment? Longitudinal research using the UK Millennium Cohort Study

    Parkes, A.; Sweeting, H.; Wight, D.; M. Henderson

    2013-01-01

    Background: Screen entertainment for young children has been associated with several aspects of psychosocial adjustment. Most research is from North America and focuses on television. Few longitudinal studies have compared the effects of TV and electronic games, or have investigated gender differences. Purpose: To explore how time watching TV and playing electronic games at age 5 years each predicts change in psychosocial adjustment in a representative sample of 7 year-olds from the UK. ...

  17. Influence of Maternal and Child Lifestyle-Related Characteristics on the Socioeconomic Inequality in Overweight and Obesity among 5-year-old Children; The “Be Active, Eat Right” Study

    Lydian Veldhuis; Ineke Vogel; Lenie van Rossem; Renders, Carry M.; HiraSing, Remy A; Mackenbach, Johan P; Hein Raat

    2013-01-01

    It is unclear whether the socioeconomic inequality in prevalence of overweight and obesity is already present among very young children. This study investigates the association between overweight and socioeconomic status (SES, with maternal educational level as an indicator of SES) among 5-year-old children. This cross-sectional study uses baseline data from 5-year-olds of Dutch ethnicity (n = 5,582) and their mothers collected for the “Be active, eat right” study. Compared to children of mot...

  18. Neuropathologic Studies of the Baltimore Longitudinal Study of Aging (BLSA)

    O’Brien, Richard J.; Susan M. Resnick; Zonderman, Alan B; Ferrucci, Luigi; Crain, Barbara J.; Pletnikova, Olga; Rudow, Gay; Iacono, Diego; Riudavets, Miguel A.; Driscoll, Ira; Price, Donald L.; Martin, Lee J.; Troncoso, Juan C.

    2009-01-01

    The Baltimore Longitudinal Study of Aging (BLSA) was established in 1958 and is one the oldest prospective studies of aging in the USA and the world. The BLSA is supported by the National Institute of Aging (NIA) and its mission is to learn what happens to people as they get old and how to sort out changes due to aging and from those due to disease or other causes. In 1986, an autopsy program combined with comprehensive neurologic and cognitive evaluations was established in collaboration wit...

  19. Longitudinal bunch compression study with induction voltage modulator

    Nakayama Akira; Sakai Yasuo; Miyazaki Yoshifumi; Kikuchi Takashi; Nakajima Mitsuo; Horioka Kazuhiko

    2013-01-01

    For the beam driver of inertial confinement fusion, the technology to compress a charged particle beam in longitudinal direction is crucially important. However, the quality of the beam is expected to be deteriorated when the beam is rapidly compressed in longitudinal direction. In order to investigate the beam dynamics during bunch compression, we made a compact beam compression system and carried out beam compression experiments. In this paper, we show the background of our study and recent...

  20. MALOCCLUSIONS AND QUALITY OF LIFE. Cross-sectional and longitudinal studies in children.

    Dimberg, Lillemor

    2015-01-01

    There are few longitudinal studies of the prevalence of malocclusions and possible self-correction of malocclusions during the development of the dentition. Early intervention might be unnecessary if self-correction of the malocclusion occurs during the transition from the primary to the permanent dentition. Most studies are cross-sectional and in those of longitudinal design, the results are inconsistent and difficult to interpret. Malocclusions may or may not influence the quality of life in children and adolescents. Thus, evaluations of the influence of different malocclusions on quality of life will certainly underpin a broader understanding and knowledge about how malocclusions affect the daily life of young patients. This information may also be important when it comes to assessing the most appropriate time for starting orthodontic treatment, not only from a professional point of view, but also, most importantly, from the patients' perspective. The overall aim of this thesis was therefore to evaluate the prevalence of malocclusions, and to document changes occurring during the development of the dentition, from the primary dentition stage at age 3, through the mixed dentition at age 7, to the early permanent dentition at age 11.5 years. Further aims were to review the current state of knowledge about the impact of malocclusions on oral health related quality of life (OHRQoL) and to investigate how malocclusions affect the quality of life in a cohort of children, aged 11.5 years, whose dental care is provided by the Swedish Public Dental Service. PMID:26642595

  1. The F-GAMMA program: Multi-frequency study of Active Galactic Nuclei in the Fermi era. Program description and the first 2.5 years of monitoring

    Fuhrmann, L; Zensus, J A; Nestoras, I; Marchili, N; Pavlidou, V; Karamanavis, V; Ungerechts, H; Krichbaum, T P; Larsson, S; Lee, S S; Max-Moerbeck, W; Myserlis, I; Pearson, T J; Readhead, A C S; Richards, J L; Sievers, A; Sohn, B W

    2016-01-01

    To fully exploit the scientific potential of the Fermi mission, we initiated the F-GAMMA program. Between 2007 and 2015 it was the prime provider of complementary multi-frequency monitoring in the radio regime. We quantify the radio variability of gamma-ray blazars. We investigate its dependence on source class and examine whether the radio variability is related to the gamma-ray loudness. Finally, we assess the validity of a putative correlation between the two bands. The F-GAMMA monitored monthly a sample of about 60 sources at up to twelve radio frequencies between 2.64 and 228.39 GHz. We perform a time series analysis on the first 2.5-year dataset to obtain variability parameters. A maximum likelihood analysis is used to assess the significance of a correlation between radio and gamma-ray fluxes. We present light curves and spectra (coherent within ten days) obtained with the Effelsberg 100-m and IRAM 30-m telescopes. All sources are variable across all frequency bands with amplitudes increasing with freq...

  2. Analysis of repeated outcome measures from longitudinal studies

    Yuanjia WANG; Naihua DUAN

    2011-01-01

    @@ In many clinical studies repeated measurements of an outcome are collected over time.For example,in an 8-week study of treatment for obsessive compulsive disorder,the severity of the disorder may be measured weekly using the Yale-Brown-Obsessive-Compulsive-Disorder-Scale (YBOCS).For each study participant who completes the study,there will be nine repeated measures of YBOCS (a baseline assessment plus eight assessments during the course of treatment).Such a study in which participants are followed and measured repeatedly over time is called a longitudinal study and the resulting data are called longitudinal data.

  3. Social Isolation and Mental Health at Primary and Secondary School Entry: A Longitudinal Cohort Study

    Matthews, Timothy; Danese, Andrea; Wertz, Jasmin; Ambler, Antony; Kelly, Muireann; Diver, Ashleen; Caspi, Avshalom; Moffitt, Terrie E.; Arseneault, Louise

    2015-01-01

    Objective We tested whether children who are socially isolated early in their schooling develop mental health problems in early adolescence, taking into account their mental health and family risk at school entry. Method We used data from the Environmental Risk (E-Risk) Longitudinal Twin Study, a birth cohort of 2,232 children born in England and Wales in 1994 and 1995. We measured social isolation using mothers’ and teachers’ reports at ages 5 and 12 years. We assessed mental health symptoms via mothers’ and teachers’ ratings at age 5 and self-report measures at age 12. We collected mother-reported information about the family environment when children were 5 years old. We conducted regression analyses to test concurrent and longitudinal associations between early family factors, social isolation, and mental health difficulties. Results At both primary and secondary school, children who were socially isolated experienced greater mental health difficulties. Children with behavioral problems or attention-deficit/hyperactivity disorder (ADHD) symptoms at age 5 years had an elevated risk of becoming more socially isolated at age 12. However, children who were isolated at age 5 did not have greater mental health symptoms at age 12, over and above pre-existing difficulties. Conclusion Although social isolation and mental health problems co-occur in childhood, early isolation does not predict worse mental health problems later on. However, children who exhibit problematic behaviors may struggle to cope with the social challenges that accompany their progression through the early school years. PMID:25721188

  4. Does Theory of Mind in Pre-Kindergarten Predict the Ability to Think about a Reader's Mind in Elementary School Compositions? A Longitudinal Study

    Peskin, Joan; Comay, Julie; Chen, Xi; Prusky, Carly

    2016-01-01

    A critical skill in emergent writing is the developing ability to take the perspective of different readers; however, the precursors of this skill have not yet been identified. In this longitudinal study, 105 children (90 after attrition) were tested at 3 time points: pre-kindergarten (3-4 years old, n = 105), kindergarten (5 years old, n = 97),…

  5. Retrospective Cohort Study Comparing Neonatal Outcomes of Women Treated with Glyburide or Insulin in Gestational Diabetes: A 5-Year Experience in a South Indian Teaching Hospital

    Jiji Elizabeth Mathews

    2011-01-01

    Full Text Available Objective: To assess the effectiveness of glyburide in preventing complications of gestational diabetes in neonates as compared to insulin. Materials and Methods: Information from birth register, maternal and neonatal records were obtained. Five hundred and seventy-seven gestational diabetics with moderate hyperglycemia i.e., with highest fasting plasma glucose value of ≤130 mg/dl and/or highest post-prandial value of ≤250 mg/dl treated with insulin or glyburide were included from a cohort of 769 women needing additional therapy to initial diet therapy during a 5-year period. Thus neonatal outcomes of 303 women treated with insulin and 274 women treated with glyburide were compared. Results: Baseline plasma glucose levels in the group treated with insulin were higher. The mean birth weight (SD of the neonates in women treated with insulin was 3021.3 g (604.19 as compared to 3104.6 g (499.35, P = 0.07 in the group treated with glyburide. Neonatal outcomes such as hypoglycemia (4.9%, 3.6%, P = 0.44, hypocalcemia (1.3%, 0.7%, P = 0.48, polycythemia (1.7%, 0.7%, P = 0.31, macrosomia (11.6%, 8.7%, P = 0.26, congenital anomalies (2.1%, 2.3%, P = 0.87, birth trauma (1.4%, 1.2%, P = 0.79 were similar in both groups. Neonates of women treated with insulin were more likely to have hyperbilirubinemia (11.5%, 6.5%, P = 0.03. Conclusion: Neonatal outcomes of women treated with glyburide were comparable to those in women treated with insulin. More number of neonates of mothers treated with insulin had hyperbilirubinemia compared to neonates of mothers treated with glyburide (11.5%, 6.5% P = 0.03.

  6. Separation-Individuation of Late Adolescents : A Longitudinal Study

    Aslan, Sevda; Gelbal, Selahattin

    2016-01-01

    The aim of this study was to demonstrate the change in separation-individuation between late adolescents in the first, second, third and fourth year of higher education. The study sample used for this longitudinal study consisted of 148 students attending class studies, computer education and science education departments of Kirikkale University.…

  7. Towards personalized diagnostics via longitudinal study of the human plasma N-glycome.

    Hennig, René; Cajic, Samanta; Borowiak, Matthias; Hoffmann, Marcus; Kottler, Robert; Reichl, Udo; Rapp, Erdmann

    2016-08-01

    Facilitated by substantial advances in analytical methods, plasma N-glycans have emerged as potential candidates for biomarkers. In the recent years, several investigations could link aberrant plasma N-glycosylation to numerous diseases. However, due to often limited specificity and sensitivity, only a very limited number of glycan biomarkers were approved by the authorities up to now. The inter-individual heterogeneity of the plasma N-glycomes might mask disease related changes in conventional large cross-sectional cohort studies, with a one-time sampling approach. But, a possible benefit of longitudinal sampling in biomarker discovery could be, that already small changes during disease progression are revealed, by monitoring the plasma N-glycome of individuals over time. To evaluate this, we collected blood plasma samples of five healthy donors over a time period of up to six years (min. 1.5years). The plasma N-glycome was analyzed by xCGE-LIF, to investigate the intra-individual N-glycome variability over time. It is shown, that the plasma N-glycome of an individual is remarkably stable over a period of several years, and that observed small longitudinal changes are independent from seasons, but significantly correlated with lifestyle and environmental factors. Thus, the potential of future longitudinal biomarker discovery studies could be demonstrated, which is a further step towards personalized diagnostics. This article is part of a Special Issue entitled "Glycans in personalised medicine" Guest Editor: Professor Gordan Lauc. PMID:27038647

  8. Goal Setting and Student Achievement: A Longitudinal Study

    Moeller, Aleidine J.; Theiler, Janine M.; Wu, Chaorong

    2012-01-01

    The connection between goals and student motivation has been widely investigated in the research literature, but the relationship of goal setting and student achievement at the classroom level has remained largely unexplored. This article reports the findings of a 5-year quasi-experimental study examining goal setting and student achievement in…

  9. LONGITUDINAL STUDIES OF MUSICALLY GIFTED SCHOOLGIRLS

    Svetlana N. Loseva

    2016-01-01

    Full Text Available The aim of the article is to consider the empirical aspects of the development of musical gifted schoolgirls in vocal and choral activities.Methods. Scientific methods of research (observation, questionnaire, interview, formative experiment, longitude, testing are used. Data are analyzed using a complex of psychodiagnostic techniques: culture and free intelligence test by R. Cattell; the modified creative test by F. Williams; personal multifactorial questionnaire by R. Cattell. The reliability of the results and the validity of the findings is provided by the use of reliable and proven in the domestic and foreign psychology methods and techniques, using different statistical methods of data processing, the definition of parametric and non-parametric statistical tests (Student’s t-criterion, Spearman’s rank correlation, criterion U-Mann – Whitney, criterion T-Wilcoxon, L-criterion trends Page.Results and scientific novelty. Results of longitudinal research of development of musical aptitude are presented. Experimental work in which schoolgirls of 8–15 years participated, was carried out on the basis of creative choral collectives of Irkutsk within three years. Features of development of the pupils who are engaged in singing are revealed. It is established that in process of development of specially developed program (comprehension of emotional and semantic aspects of perception of a piece of music, finding of ability to distinguish musical timbres and the general coloring of sounding etc. analytical and intonation hearing improves under pupils’ age. Regular long singing trainings promote formation of cogitative operations: active development of divergent, rational and logical thinking and intelligence in general, and also acquisition of skills of a self-assessment. Besides, such occupations dispose children and teenagers to emotional responsiveness and spiritual self-improvement.Practical significance. The research

  10. Unemployment and psychological distress among graduates: A longitudinal study

    Schaufeli, Wilmar B.; Van Yperen, Nico W.

    1992-01-01

    A longitudinal study which addresses the relationship between unemployment and psychological distress in Dutch technical college graduates is presented. Two samples were studied: sample 1 (N = 635) consisted of students leaving technical college and sample 2 (N = 487) consisted of technical college

  11. Homeschooling Education: Longitudinal Study of Methods, Materials, and Curricula

    Hanna, Linda G.

    2012-01-01

    In a comprehensive study of two-hundred fifty homeschooling families in urban, rural and suburban areas of the Commonwealth of Pennsylvania, the researcher examined all aspects of the instruction, materials and curricula employed by the families in a ten-year longitudinal study from 1998 through 2008. The researcher conducted interviews and…

  12. English as a Foreign Language Spelling Development: A Longitudinal Study

    Kahn-Horwitz, Janina; Sparks, Richard L.; Goldstein, Zahava

    2012-01-01

    English as a foreign language (EFL) spelling was examined longitudinally three times (4th, 9th, 12th grades) during 9 years of EFL study among Hebrew first language (L1) students. The study examined the impact of L1 literacy variables including phonemic awareness, word attack, and spelling on EFL spelling and the relationship between EFL literacy…

  13. Suprasegmental Phonology Development and Reading Acquisition: A Longitudinal Study

    Calet, Nuria; Gutiérrez-Palma, Nicolás; Simpson, Ian C.; González-Trujillo, M. Carmen; Defior, Sylvia

    2015-01-01

    Previous studies implicate suprasegmental phonology in reading acquisition. However, little is known about how suprasegmental sensitivity develops or how it contributes to reading. Here, 130 Spanish primary-school children participated in this 2-year longitudinal study. Nonlinguistic rhythm, lexical-stress sensitivity and metrical-stress…

  14. Evidence of functional declining and global comorbidity measured at baseline proved to be the strongest predictors for long-term death in elderly community residents aged 85 years: a 5-year follow-up evaluation, the OCTABAIX study

    Formiga, Francesc; Ferrer, Assumpta; Padros, Gloria; Montero, Abelardo; Gimenez-Argente, Carme; Corbella, Xavier

    2016-01-01

    Objective To investigate the predictive value of functional impairment, chronic conditions, and laboratory biomarkers of aging for predicting 5-year mortality in the elderly aged 85 years. Methods Predictive value for mortality of different geriatric assessments carried out during the OCTABAIX study was evaluated after 5 years of follow-up in 328 subjects aged 85 years. Measurements included assessment of functional status comorbidity, along with laboratory tests on vitamin D, cholesterol, CD4/CD8 ratio, hemoglobin, and serum thyrotropin. Results Overall, the mortality rate after 5 years of follow-up was 42.07%. Bivariate analysis showed that patients who survived were predominantly female (P=0.02), and they showed a significantly better baseline functional status for both basic (P<0.001) and instrumental (P<0.001) activities of daily living (Barthel and Lawton index), better cognitive performance (Spanish version of the Mini-Mental State Examination) (P<0.001), lower comorbidity conditions (Charlson) (P<0.001), lower nutritional risk (Mini Nutritional Assessment) (P<0.001), lower risk of falls (Tinetti gait scale) (P<0.001), less percentage of heart failure (P=0.03) and chronic obstructive pulmonary disease (P=0.03), and took less chronic prescription drugs (P=0.002) than nonsurvivors. Multivariate Cox regression analysis identified a decreased score in the Lawton index (hazard ratio 0.86, 95% confidence interval: 0.78–0.91) and higher comorbidity conditions (hazard ratio 1.20, 95% confidence interval: 1.08–1.33) as independent predictors of mortality at 5 years in the studied population. Conclusion The ability to perform instrumental activities of daily living and the global comorbidity assessed at baseline were the predictors of death, identified in our 85-year-old community-dwelling subjects after 5 years of follow-up. PMID:27143867

  15. Theoretical study of transverse-longitudinal emittance coupling

    Qin, H; Davidson, R C; Chung, M; Barnard, J J; Wang, T F

    2011-04-14

    The effect of a weakly coupled periodic lattice in terms of achieving emittance exchange between the transverse and longitudinal directions is investigated using the generalized Courant-Snyder theory for coupled lattices. Recently, the concept and technique of transverse-longitudinal emittance coupling have been proposed for applications in the Linac Coherent Light Source and other free-electron lasers to reduce the transverse emittance of the electron beam. Such techniques can also be applied to the driver beams for the heavy ion fusion and beam-driven high energy density physics, where the transverse emittance budget is typically tighter than the longitudinal emittance. The proposed methods consist of one or several coupling components which completely swap the emittances of one of the transverse directions and the longitudinal direction at the exit of the coupling components. The complete emittance exchange is realized in one pass through the coupling components. In the present study, we investigate the effect of a weakly coupled periodic lattice in terms of achieving emittance exchange between the transverse and longitudinal directions. A weak coupling component is introduced at every focusing lattice, and we would like to determine if such a lattice can realize the function of emittance exchange.

  16. Longitudinal bunch compression study with induction voltage modulator

    Nakayama Akira

    2013-11-01

    Full Text Available For the beam driver of inertial confinement fusion, the technology to compress a charged particle beam in longitudinal direction is crucially important. However, the quality of the beam is expected to be deteriorated when the beam is rapidly compressed in longitudinal direction. In order to investigate the beam dynamics during bunch compression, we made a compact beam compression system and carried out beam compression experiments. In this paper, we show the background of our study and recent progress of the beam compression experiments.

  17. Interracial Contact and Racial Constancy: A Multi-Site Study of Racial Intergroup Bias in 3-5 Year Old Anglo-British Children

    Rutland, Adam; Cameron, Lindsey; Bennett, Laura; Ferrell, Jennifer

    2005-01-01

    This paper examined the influence of interracial contact and racial constancy on the racial intergroup bias of young Anglo-British children. This multi-site study was conducted in areas of Great Britain that varied in terms of racial diversity. The study also investigated whether preschool children express bias on positive, but not negative,…

  18. Job insecurity and the use of antidepressant medication among Danish employees with and without a history of prolonged unemployment: a 3.5-year follow-up study

    Rugulies, R; Thielen, K; Nygaard, E;

    2010-01-01

    A study was undertaken to investigate whether job insecurity predicts incident use of antidepressant medication and whether the association is modified by a history of prolonged unemployment.......A study was undertaken to investigate whether job insecurity predicts incident use of antidepressant medication and whether the association is modified by a history of prolonged unemployment....

  19. C-Reactive Protein Predicts Progression of Peripheral Arterial Disease in Patients with Type 2 Diabetes: A 5-Year Follow-Up Study

    Popović Ljiljana

    2014-09-01

    Full Text Available Background: Previous studies have indicated that high sensitivity C-reactive protein (hs-CRP is a risk factor for the peripheral arterial disease (PAD in diabetes. This study aimed to evaluate the possible predictive significance of hs-CRP for the development and progression of PAD in patients with type 2 diabetes (T2D.

  20. A STUDY OF RELATIONSHIP BETWEEN WEIGHT, HEIGHT, HEAD & CHEST CIRCUMFERENCE IN CHILDREN BETWEEN 3 TO 5 YEARS IN THE MALWA REGION OF MADHYA PRADESH

    Wankhede,, Mahendra; Bhandari; Ravi

    2015-01-01

    INTRODUCTION : The growth & development are the important attributes of childhood. The studies on physical development & growth of infants & children are important as they are determinants of a nation’s health. The appr eciation of progress of any country in the field of health can be made from time to time with the help of such studies. The principal aim of the nutritional assessment of a community is to map out the magnitude & geographic distribution of malnutrition & ...

  1. CORRELATION OF MRI GRADING OF BONE STRESS INJURIES WITH CLINICAL RISK FACTORS AND RETURN TO PLAY: A 5-YEAR PROSPECTIVE STUDY IN COLLEGIATE TRACK AND FIELD ATHLETES

    Nattiv, A; Kennedy, G; Barrack, MT; Abdelkerim, A; Goolsby, MA; Arends, JC; Seeger, LL

    2013-01-01

    Background: Bone stress injuries are common in track and field athletes. Knowledge of risk factors and correlation of these to magnetic resonance imaging (MRI) grading could be helpful in determining recovery time. Purpose: To examine the relationships between MRI grading of bone stress injuries with clinical risk factors and time to return to sport in collegiate track and field athletes. Study Design: Cohort study (prognosis); Level of evidence, 2. Methods: A total of 211 male and female col...

  2. Measuring medial longitudinal arch deformation during gait. A reliability study

    Bencke, Jesper; Christiansen, Ditte; Jensen, Anne Kathrine Bendrup; Okholm, Anne; Sonne-Holm, Stig; Bandholm, Thomas

    2012-01-01

    Clinical evaluation of medial longitudinal arch deformation (MLAD) during walking gait is often estimated from static measures of e.g. navicular drop (ND) measured during quiet standing. The aim of the present study was to test the reliability of a new three-dimensional method of measuring the MLAD...

  3. A Longitudinal Study of Principals' Activities and Student Performance

    May, Henry; Huff, Jason; Goldring, Ellen

    2012-01-01

    Although a substantial amount of research on school leadership has focused on what principals may do to improve teaching and learning, little of this research has explored how principals' time spent on leadership activities may relate to and possibly affect student performance. This article presents results from a 3-year longitudinal study of…

  4. A Longitudinal Study of Pretend Play in Autism

    Rutherford, M. D.; Young, Gregory S.; Hepburn, Susan; Rogers, Sally J.

    2007-01-01

    This study describes a longitudinal design (following subjects described in Rutherford & Rogers [2003, "Journal of Autism and Developmental Disorder", 33, 289-302]) to test for predictors of pretend play competence in a group of children with autism. We tested the hypothesis that developmental change in pretend play performance can be predicted by…

  5. Pain Perceptions of the Oldest Old: A Longitudinal Study

    Zarit, Steven H.; Griffiths, Patricia C.; Berg, Stig

    2004-01-01

    Purpose: This study assessed self-reported pain in the oldest old and examined its changes over time and in relation to other measures of health and functioning. Design and Methods: A population-based sample of the oldest old (86-92 years of age) residing in Sweden who were participating in a multiwave longitudinal investigation were interviewed…

  6. Minor Delinquency and Immigration: A Longitudinal Study among Male Adolescents

    Titzmann, Peter F.; Silbereisen, Rainer K.; Mesch, Gustavo

    2014-01-01

    On the basis of general theories of delinquency and the specific situation of immigrants, this longitudinal study investigated predictors of initial levels and rates of change in delinquency among 188 male ethnic German Diaspora immigrants from the former Soviet Union (FSU) in Germany, 237 male native German adolescents, and 182 male Jewish…

  7. Anxiety Sensitivity and Panic Attacks: A 1-Year Longitudinal Study

    Li, Wen; Zinbarg, Richard E.

    2007-01-01

    The hypothesis that anxiety sensitivity (AS) is a risk factor for panic genesis has obtained compelling support, but the clinical/practical importance of AS in panic genesis has been questioned. In addition, the association between panic experience and AS increase has not been clearly demonstrated. Through this 1-year longitudinal study among…

  8. Predictors of career orientation: 50-year longitudinal study

    Millová, Katarína; Blatný, Marek; Jelínek, Martin

    Istanbul: Turkish Psychological Association, 2011. s. 953-953. [European Congress of Psychology /12./. 04.07.2011-08.07.2011, Istanbul] R&D Projects: GA ČR GAP407/10/2410 Institutional research plan: CEZ:AV0Z70250504 Keywords : career orientation * middle adulthood * longitudinal study Subject RIV: AN - Psychology

  9. Longitudinal Study on Reciprocity between Personality Traits and Parenting Stress

    Rantanen, Johanna; Tillemann, Kati; Metsäpelto, Riitta-Leena; Kokko, Katja; Pulkkinen, Lea

    2015-01-01

    Reciprocal associations between the Big Five personality traits and parenting stress--including both parents' feelings of their distress and perception of their incompetence as parents--were studied with 248 participants (49% of which were males). Longitudinal data, collected at ages 33/36, 42 and 50 years, were used. Cross-lagged path…

  10. Accelerated brain aging in schizophrenia : A longitudinal pattern recognition study

    Schnack, Hugo G.; Van Haren, Neeltje E M; Nieuwenhuis, Mireille; Pol, Hilleke E Hulshoff; Cahn, Wiepke; Kahn, René S.

    2016-01-01

    OBJECTIVE: Despite the multitude of longitudinal neuroimaging studies that have been published, a basic question on the progressive brain loss in schizophrenia remains unaddressed: Does it reflect accelerated aging of the brain, or is it caused by a fundamentally different process? The authors used

  11. A Longitudinal Study on Internship Effectiveness in Vocational Higher Education

    Wan, Chin-Sheng; Yang, Jen-te; Cheng, Shu-yun; Su, Chiakai

    2013-01-01

    A cooperative education experience (or internship placement) is an essential component of the curricula of vocational higher education. The efficacy of internship placements has become one of the major concerns facing those who develop education curricula. The purpose of this longitudinal study was to explore the relationships among the…

  12. A Longitudinal Study of Early Adolescent Precursors to Running Away

    Tyler, Kimberly A.; Bersani, Bianca E.

    2008-01-01

    Although previous research has examined correlates of running away among samples of currently homeless and runaway adolescents, little is known about what factors will predict the likelihood that a housed adolescent with no prior history of running away will leave home. As such, the current study uses the National Longitudinal Survey of Youth to…

  13. Criminal Victimization and Crime Risk Perception: A Multilevel Longitudinal Study

    Russo, Silvia; Roccato, Michele; Vieno, Alessio

    2013-01-01

    In a national sample of the Italian population, surveyed four times between October 2002 and January 2007 (N = 2,008), we performed a multilevel longitudinal study aimed at predicting the increase in crime risk perception as a function of three families of independent variables, respectively lying at the within individual level (direct…

  14. The Colorado Longitudinal Twin Study of Reading Difficulties and ADHD: Etiologies of Comorbidity and Stability.

    Wadsworth, Sally J; DeFries, John C; Willcutt, Erik G; Pennington, Bruce F; Olson, Richard K

    2015-12-01

    Approximately 60% of children with reading difficulties (RD) meet criteria for at least one co-occurring disorder. The most common of these, attention deficit-hyperactivity disorder (ADHD), occurs in 20-40% of individuals with RD. Recent studies have suggested that genetic influences are responsible. To assess the genetic etiologies of RD and the comorbidity of RD and two ADHD symptom dimensions -- inattention (IN) and hyperactivity/impulsivity (H/I) -- we are conducting the first longitudinal twin study of RD and ADHD. Data from twin pairs in which at least one member of the pair met criteria for proband status for RD at initial assessment, and were reassessed 5 years later, were subjected to DeFries-Fulker (DF) analysis. Analyses of reading composite data indicated that over 60% of the proband deficit at initial assessment was due to genetic influences, and that reading deficits at follow-up were due substantially to the same genetic influences. When a bivariate DF model was fitted to reading performance and IN data, genetic influences accounted for 60% of contemporaneous comorbidity and over 60% of the longitudinal relationship. In contrast, analysis of the comorbidity between reading performance and H/I indicated that common genetic influences accounted for only about 20% of the contemporaneous and about 10% of the longitudinal relationships. Results indicate that (1) genetic influences on RD are substantial and highly stable; (2) the comorbidity between RD and IN is due largely to genetic influences, both contemporaneously and longitudinally; and (3) genetic influences contribute significantly less to the comorbidity between RD and H/I. PMID:26537134

  15. The relative incidence of fracture non-union in the Scottish population (5.17 million):A 5-year epidemiological study

    Mills, Leanora Anne; Simpson, Hamish

    2013-01-01

    OBJECTIVES: In the UK there are approximately 850 000 new fractures seen each year. Rates of non-union of 5-10% of fractures have been suggested, the cost to the National Health Service of treating non-union has been reported to range between £7000 and £79 000 per person yet there are little actual data available. The objective of this epidemiological study therefore is for the first time to report the rates of fracture non-union.DESIGN: A cross-sectional epidemiological study.SETTING: The po...

  16. The development of polypharmacy. A longitudinal study

    Veehof, LJG; Stewart, RE; Haaijer-Ruskamp, FM; Meyboom-de Jong, B

    2000-01-01

    Background. To date, only a few studies have been carried out on the development and progress of polypharmacy in relation to morbidity in general practices in The Netherlands. Objective. The aim of this study was to investigate the relationship between an increase in long-term drug use and the incid

  17. Sexual and urinary functioning after rectal surgery: A prospective comparative study with a median follow-up of 8.5 years

    A. Doeksen (Annemiek); J.A.H. Gooszen (Jan); P. van Duijvendijk (Peter); P.J. Tanis (Pieter); R. Bakx (Roel); J.F.M. Slors (Frederik); J.J-B. van Lanschot (Jan)

    2011-01-01

    textabstractPurpose: The purpose of this study was to prospectively compare rectal resection (RR) with colonic resection on sexual, urinary and bowel function and quality of life in both short-term and long-term. Methods: Eighty-three patients who underwent RR were compared to 53 patients who underw

  18. RETROSPECTIVE AND PROSPECTIVE STUDY OF MANAGEMENT AND OUTCOME OF BLUNT ABDOMEN TRAUMA IN TERTIARY HEALTH CENTER IN LAST 5 - YEAR 2009 - 2014

    Raikwar

    2015-05-01

    Full Text Available AIMS: 1. To study the incidence of various intra - abdominal and extra - abdominal injuries in blunt abdominal trauma in tertiary health care center in five year (2009 - 14 . 2 . To study the relationship between mode of injury , severity of injury and clinical presentation and its outcome , mortality and morbidity. 3 . To study modalities for evaluating the abdomen after blunt abdominal trauma. 4 . To evaluate the major indication for operation in each cases . 5 . To study of outcome , mortality and morbidity . SETTINGS AND DESIGN: This study carried out in the Department of Surgery , MGM Medical College , M.Y. Hospital Indore and Trauma Department , M.Y. Hospital Indore both retrospectively and prospectively in patients with Blunt abdominal trauma over the period of from 2009 to 2014 with co - operation of the staff of Medicolegal section , Central record room and residents looking after the admitted pat ients. MATERIALS AND METHODS: On admission to hospital patient’s name , age , sex , address , registration number and date and time of admission , length of delay in treatment taken noted and mode of trauma also noted. Patient’s presenting complaint , detail his tory and time of trauma noted. RESULTS: During this study total 250 admission were included 170 ( P rospective and 80 ( R etrospective. There were over all 201 males (80.4% and 49 female (19.6%. Mortality was maximum due to RTA 64.52%. Highest number of ca ses (65 in the third decade i.e. 26%. Among these injuries hemoperitoneum was found in 94 cases i.e.37.6%. Small intestine (ileal>jejunal injury 45 cases i.e. , 18% was most common hollow viscous injury. In solid organ injury there was maximum incidence o f liver injury 34 cases. i.e. , 13.6% . CONCLUSION: This study concludes that young males are more prone to trauma and maximum blunt trauma is asso ciated with RTA. Almost half of patients required laparotomy and found injury to liver and small intestine in max cases. Overall

  19. A clinico-pathological study of orbito-ocular tumors at Ahmadu Bello University Teaching Hospital, Shika-Zaria, Nigeria: A 5-year review

    Dominic Chinda

    2012-01-01

    Full Text Available Background: Orbito-ocular tumors are a common cause of morbidity and mortality in our environment. Patients often present late with unsightly fungating tumors resulting in difficult management and poor outcome. The aim of the study was to determine the clinical profile, diagnostic work-up, treatment and histo-pathological types of orbito-ocular tumors seen at Ahmadu Bello University Teaching Hospital, Shika-Zaria from June 2006 to June 2011. Materials and Methods: A retrospective analysis of all patients who presented to the eye clinic with orbito-ocular tumors during the study period was made. Information extracted incwudes patient demographics, clinical diagnoses, radiological and sonological reports, surgery performed, and histology reports as well as adjuvant chemotherapy and radiotherapy where indicated. Results: A total of 54 patients were managed during the study period. Those without histology reports were excluded from the study. Forty-nine patients were included for analysis. There were 29 male and 20 female patients giving a male to female ratio of 1.8:1. Their age range was 1.5-74 years with a mean of 22 years. Eighteen of the patients had retinoblastoma, eleven had squamous cell carcinoma, two had Kaposi′ sarcoma, and one case of nasopharyngeal carcinoma. There were 2 patients with pre-malignant conditions and 10 patients with benign lesions. Thirty-two of the patients had exenterations, sixteen had excisional biopsies, and one had enucleation. Seventy eight percent of the tumors were malignant. Conclusion: Most of the orbito-ocular tumors seen in this study were malignant. Delayed hospital presentation is a characteristic feature. Retinoblastoma and squamous cell carcinoma are the most common orbito-ocular tumors.

  20. The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma

    Busse, William W; Pedersen, Søren; Pauwels, Romain A;

    2008-01-01

    reference group. Moreover, patients in the reference group used more additional asthma medications during both the open-label and double-blind phases. CONCLUSIONS: In mild persistent asthma early intervention with inhaled budesonide was associated with improved asthma control and less additional asthma......BACKGROUND: The Inhaled Steroid Treatment as Regular Therapy in Early Asthma (START) study enrolled 7241 patients aged 5 to 66 years with recent-onset, mild persistent asthma to assess early intervention with the inhaled corticosteroid budesonide on long-term asthma control. OBJECTIVE: The open......-label phase of the START study was included to determine the effect on lung function and asthma control of adding budesonide to the reference group patients who had not initially received inhaled corticosteroids. METHODS: Patients were randomized to double-blind treatment with budesonide, 200 mug (those aged...

  1. Roll of the adjuvant radiotherapy. Kidney cancer. Stage III. Results to 5 years. Observational, descriptive, retrospective, quantitative and comparative study with data numerical description

    Kidney cancer represents 3 % of the tumors in adults. In the United States, the 45% is diagnosed in early stages. Its natural history is characterized for being absolutely unpredictable and probably related to hormonal, immunologic and unknown factors. There are patients in advanced stage with prolonged or low average survival and even with metastasis declination. These particularities along with the lack of prospective random studies make difficult to establish which is the roll of the adjuvant radiotherapy, being considered not standard since 1997

  2. Right and left cardiac function in HIV-infected patients investigated using radionuclide ventriculography and brain natriuretic peptide: a 5-year follow-up study

    Kristoffersen, U.S.; Lebech, A.M.; Gerstoft, J.;

    2008-01-01

    OBJECTIVE: The aim of the study was to determine the incidence of myocardial dysfunction in an HIV-infected population receiving state-of-the-art treatment. METHODS: Between April 2001 and July 2002, 91 HIV-infected patients had a radionuclide ventriculography performed with determination of righ...... seems that the improvement in immunocompetency and viral load has removed the problem of HIV-related cardiomyopathy. Although HAART has been suggested as a possible new cause of cardiomyopathy, we did not find any evidence of this Udgivelsesdato: 2008/3......OBJECTIVE: The aim of the study was to determine the incidence of myocardial dysfunction in an HIV-infected population receiving state-of-the-art treatment. METHODS: Between April 2001 and July 2002, 91 HIV-infected patients had a radionuclide ventriculography performed with determination of right...... mean RVEF was found. No patients had increased BNP and no change in mean plasma BNP was found. CONCLUSIONS: HIV-related cardiomyopathy appears not to constitute a problem in closely monitored, well-treated HIV-infected patients. Compared with pre-highly active antiretroviral therapy (HAART) studies, it...

  3. Corporal punishment and child behavioral and cognitive outcomes through 5 years-of-age: Evidence from a contemporary urban birth cohort study

    MacKenzie, Michael J.; Nicklas, Eric; Waldfogel, Jane; Brooks-Gunn, Jeanne

    2012-01-01

    This study examined the prevalence and determinants of spanking of children at 3 years-of-age, and the associations between spanking and externalizing behavior and receptive verbal ability at age 5. Overall, we find maternal spanking rates of 55.2% and paternal rates of 43.2% at age 3. Mothers facing greater stress and those who spanked earlier are more likely to spank at age 3, whereas those who report a supportive partner during pregnancy and those who were not U.S. born were less likely to...

  4. Serum ferritin levels and the development of metabolic syndrome and its components: a 6.5-year follow-up study

    Hämäläinen, Päivi; Saltevo, Juha; Kautiainen, Hannu; Mäntyselkä, Pekka; Vanhala, Mauno

    2014-01-01

    Background The aim of this study was to investigate the relationship between changes in serum ferritin concentrations and the development of metabolic syndrome (MetS) and its components over a 6.5 year follow-up period in Finnish adults. Methods Adults born in Pieksämäki, Finland, in 1942, 1947, 1952, 1957, and 1962 (n = 1294) were invited to health checkups between 1997 and 1998 and 2003 and 2004. All of the required variables for both checkups were available from 691 (53%) subjects (289 men...

  5. SPECTRUM OF CERVICAL LESIONS IN CIMS, BILASPUR: A 5 YEAR RETROSPECTIVE STUDY OF 215 CASES IN A TERTIARY HOSPITAL OF CENTRAL INDIA

    Sadhna

    2015-10-01

    Full Text Available BACKGROUND AND OBJEC TIVE: Cancer of the cervix is a leading cause of morbidity and mortality among women W orld W ide. Therefore to curb the disease there is need of awareness of this disease. This study is aimed to categorize the premalignant and malignant lesions at the earliest, to reduce the mortality and morbidity. It also aimed to know the incidence of malignancies at our set up and to calculate distribution of patient in relation to parity and symptoms. DESIGN AND SETTING: Study included 215 patients with complain of white dis charge per vagina, per vaginal bleeding and backache attending the gynecology OPD over a period of 05 years. PATIENT AND METHODS: Patients were subjected to cervical biopsy and biopsies were sent to pathology department. Detailed clinical history, age, age at marriage, parity and socio - economic status was obtained. RESULT: Result were classified histopathological l y as inflammatory lesions 70 cases, polypoidal lesion were 30, LSIL accounted for 32 cases and HSIL were 20 cases and 30 were malignant lesions. U nder malignant category moderately differentiated squamous cell carcinoma was the commonest. Maximum numbers of patients were subjected to cervical biopsies in 3 rd decade of life. Malignancies were common in 3 rd & 4 th decade of life. Most of the cases were of parity 4. CONCLUSION : Tissue biopsy is a valuable diagnostic procedure on which surgeons and radiologists still rely.

  6. Minimum 5-year follow-up study on the effects of the Wallis dynamic stabilization system in the treatment of lumbar degenerative disease

    Chen Zheng; Peng Baogan; Li Duanming; Pang Xiaodong; Yang Hong

    2014-01-01

    Background Short-term outcomes of the Wallis system in the treatment of lumbar degenerative disease (LDD) have been shown to be effective,whereas there is a paucity of studies on the mid-long-term effects of the treatment of the Wallis system.This study was to evaluate the mid-long-term effects of the Wallis dynamic stabilization system in the treatment of LDD.Methods A total of 26 patients who received the treatment of the Wallis system between February 2008 and January 2009 were included in the study,with 14 patients (Group 1) with L4/5 disc herniation and 12 patients (Group 2) with L5/S1 disc herniation and L4/5 intervertebral disc degeneration (IDD).Visual analog scale (VAS) and Oswestry Disability Index (ODI) were used to evaluate the clinical outcomes and lumbar x-rays and MRI were obtained to observe imaging changes before and after operation.Results The mean follow-up period was (63.50±2.12) months.The mean ODI and VAS scores decreased obviously three months and five years after operation (P <0.05).In Groups 1 and 2,L4/5 Cobb angle and range of motion (ROM) decreased and L4/5 posterior disc height increased at the last follow-up (P <0.05).There were no statistically significant changes in L4/5 anterior disc height and L3/4 University of California at Los Angeles grading before and after operation.There was no statistically significant change in Pfirrmann grading system of L4/5 IDD in Group 2 before and after operation.Adjacent segment degeneration at the last follow-up was found in two patients (2/26,7.69%) and Modic changes in L4/5 endplates were detected in one patient (1/26,3.85%).Conclusions The mid-long-term effects of the Wallis system in the treatment of LDD were satisfied.The Wallis system,as a dynamic stabilization system,which can preserve some ROM of the fixed segment,sustain the lumbar stabilization,and prevent adjacent segment disease and fixed segment degeneration,is an effective instrument to treat LDD.

  7. SU-E-J-265: Feasibility Study of Texture Analysis for Prognosis of Local Tumor Recurrence Within 5-Years for Pharyngeal-Laryngeal Carcinoma Patients Received Radiotherapy Treatment

    Huang, W; Tu, S [Chang Gung University, Kwei-shan, Tao-Yuan, Taiwan (China)

    2015-06-15

    Purpose: Pharyngeal and laryngeal carcinomas (PLC) are among the top leading cancers in Asian populations. Typically the tumor may recur and progress in a short period of time if radiotherapy fails to deliver a successful treatment. Here we used image texture features extracted from images of computed tomography (CT) planning and conducted a retrospective study to evaluate whether texture analysis is a feasible approach to predict local tumor recurrence for PLC patients received radiotherapy treatment. Methods: CT planning images of 100 patients with PLC treated by radiotherapy at our facility between 2001 and 2010 are collected. These patients were received two separate CT scans, before and mid-course of the treatment delivery. Before the radiotherapy, a CT scanning was used for the first treatment planning. A total of 30 fractions were used in the treatment and patients were scanned with a second CT around the end of the fifteenth delivery for an adaptive treatment planning. Only patients who were treated with intensity modulated radiation therapy and RapidArc were selected. Treatment planning software of Eclipse was used. The changes of texture parameters between two CT acquisitions were computed to determine whether they were correlated to the local tumor recurrence. The following texture parameters were used in the preliminary assessment: mean, variance, standard deviation, skewness, kurtosis, energy, entropy, inverse difference moment, cluster shade, inertia, cluster prominence, gray-level co-occurrence matrix, and gray-level run-length matrix. The study was reviewed and approved by the committee of our institutional review board. Results: Our calculations suggested the following texture parameters were correlated with the local tumor recurrence: skewness, kurtosis, entropy, and inertia (p<0.0.05). Conclusion: The preliminary results were positive. However some works remain crucial to be completed, including addition of texture parameters for different image

  8. SU-E-J-265: Feasibility Study of Texture Analysis for Prognosis of Local Tumor Recurrence Within 5-Years for Pharyngeal-Laryngeal Carcinoma Patients Received Radiotherapy Treatment

    Purpose: Pharyngeal and laryngeal carcinomas (PLC) are among the top leading cancers in Asian populations. Typically the tumor may recur and progress in a short period of time if radiotherapy fails to deliver a successful treatment. Here we used image texture features extracted from images of computed tomography (CT) planning and conducted a retrospective study to evaluate whether texture analysis is a feasible approach to predict local tumor recurrence for PLC patients received radiotherapy treatment. Methods: CT planning images of 100 patients with PLC treated by radiotherapy at our facility between 2001 and 2010 are collected. These patients were received two separate CT scans, before and mid-course of the treatment delivery. Before the radiotherapy, a CT scanning was used for the first treatment planning. A total of 30 fractions were used in the treatment and patients were scanned with a second CT around the end of the fifteenth delivery for an adaptive treatment planning. Only patients who were treated with intensity modulated radiation therapy and RapidArc were selected. Treatment planning software of Eclipse was used. The changes of texture parameters between two CT acquisitions were computed to determine whether they were correlated to the local tumor recurrence. The following texture parameters were used in the preliminary assessment: mean, variance, standard deviation, skewness, kurtosis, energy, entropy, inverse difference moment, cluster shade, inertia, cluster prominence, gray-level co-occurrence matrix, and gray-level run-length matrix. The study was reviewed and approved by the committee of our institutional review board. Results: Our calculations suggested the following texture parameters were correlated with the local tumor recurrence: skewness, kurtosis, entropy, and inertia (p<0.0.05). Conclusion: The preliminary results were positive. However some works remain crucial to be completed, including addition of texture parameters for different image

  9. Tourism Degree Internships: A Longitudinal Study

    Busby, Graham

    2003-01-01

    This case study briefly reviews the development of tourism degrees in the United Kingdom before considering the experiences obtained by students on year-long internship programmes over a period of 8 years. Verbatim confidential comments, from students, are provided and specific transferable skills discussed. Whilst some skills can be developed…

  10. Corporal punishment and child behavioral and cognitive outcomes through 5 years-of-age: Evidence from a contemporary urban birth cohort study.

    MacKenzie, Michael J; Nicklas, Eric; Waldfogel, Jane; Brooks-Gunn, Jeanne

    2012-01-01

    This study examined the prevalence and determinants of spanking of children at 3 years-of-age, and the associations between spanking and externalizing behavior and receptive verbal ability at age 5. Overall, we find maternal spanking rates of 55.2% and paternal rates of 43.2% at age 3. Mothers facing greater stress and those who spanked earlier are more likely to spank at age 3, whereas those who report a supportive partner during pregnancy and those who were not U.S. born were less likely to spank. Mothers and fathers in communities where spanking was more normative were more likely to spank. Fathers were less likely to spank daughters at age 3. Frequent maternal spanking at age 3 was associated with externalizing behavior and receptive vocabulary at age 5, controlling for an array of ecological risks, earlier behavior, and verbal capacity. Taking advantage of the large and diverse sample we explored potential interactions and found no evidence that race, parental warmth, normativeness, or child gender moderated the association between spanking and externalizing or receptive vocabulary. These findings add to the literature on negative consequences associated with a widely endorsed parenting practice, and highlight the need for research that explores alternative effective discipline practices and addresses parent questions of what else they could, or even should, be doing. PMID:24839402

  11. The use of covered stents for the endovascular treatment of extracranial internal carotid artery stenosis: a prospective study with a 5-year follow-up

    To evaluate the safety and feasibility of the use of covered stents for the treatment of extracranial carotid artery stenosis caused by highly embologenic plaques, and to study the long-term outcome of patients receiving such covered stents. Between 2002 and 2007, 46 patients (63% symptomatic, 78.3% male, 67 ± 8.6 years old) with internal carotid artery stenosis caused by embologenic plaques or restenosis were treated with self-expanding covered stents (Symbiot, Boston Scientific). Pre-dilatation or protecting devices were not used. Post-dilatation was applied in every patient. Each patient was followed long-term. The outcome measures were the occurrence of neurological events, and the development of in-stent restenosis, as detected by clinical examination and duplex ultrasound. The technical success rate of stenting was 100%. There were no neurological complications in the peri-procedural period. The mean follow-up period was 34.3 ± 27.7 months (the rate of patients lost to follow-up was 15.2%) during which no stroke or stroke-related deaths occurred. Restenosis was detected in 3 patients (6.5%). Covered stents provide efficient peri- and post-procedural protection against neurological complications due to embolisation from high-risk plaques during carotid artery stenting. Restenosis of covered stents appears to be infrequent during long-term follow-up. (orig.)

  12. A longitudinal study of Campylobacter distribution in a turkey

    Perko-MÀkelÀ, PÀivikki; Isohanni, Pauliina; Katzav, Marianne; Lund, Marianne; HÀnninen, Marja-Liisa; Lyhs, Ulrike

    2009-01-01

    Background: Campylobacter is the most common cause of bacterial enteritis worldwide. Handling and eating of contaminated poultry meat has considered as one of the risk factors for human campylobacteriosis.Campylobacter contamination can occur at all stages of a poultry production cycle. The objective of this study was to determine the occurrence of Campylobacter during a complete turkey production cycle which lasts for 1,5 years of time. For detection of Campylobacter, a conven...

  13. Social inequalities in injury occurrence and in disability retirement attributable to injuries: a 5 year follow-up study of a 2.1 million gainfully employed people

    Tüchsen Finn

    2007-08-01

    Full Text Available Abstract Background Inequalities in injury related disability retirement may be due to differences in injury risk and or differences in retirement given injury. The aim of the present study was to measure social inequalities in injury occurrence and injury related disability retirement. Methods All people in the Danish labour force aged 20–59 years 1 January 1997 were followed for injury related hospital contacts during 1997 and all people in the Danish labour force aged 21–54 years 1 January 1998 were followed for injury related hospital contacts during 1997 and for disability retirements during 1998–2002. As inequality indices we used excess fractions (EF i.e. the proportions of the cases that would not have occurred if the risks in each social group had been as low as they were in the occupational group with the highest skill requirements. Results With regard to the risk that an injury will occur, the EF was 36% among men and 10% among women. With regard to the risk that an injury will lead to disability retirement, the EF was 43% among men and 47% among women. The combined effect of the two types of inequalities rendered an EF for injury related disability retirement of 64% among men and 53% among women. The correlation between the case disability rate ratios among men and those among women was low (r = -0.110, P = 0.795. Conclusion The social inequality in injury related disability retirement lies only to some degree in the differences in the injury risk. More important are differences in the consequences of an injury. This was especially pronounced among the women.

  14. The Seattle Longitudinal Study: Relationship Between Personality and Cognition

    Schaie, K. Warner; Willis, Sherry L.; Caskie, Grace I. L.

    2004-01-01

    This article reviews the history, measures and principal findings of the Seattle Longitudinal Study. This study began in 1956 focusing upon age differences and age changes in cognitive abilities. Its sampling frame is a large HMO in the Pacific Northwest. The study has been expanded to investigate various influences on cognitive aging including, cognitive styles, personality traits, life styles, and family environment. Current interest is also in the early detection of risk for dementia. In a...

  15. Becoming a mental health nurse: a three year longitudinal study

    Harvey Wells; Cathy Bernal; Daniel Bressington

    2015-01-01

    This longitudinal case series study explores how students’ conceptions of ‘mental health nursing’ changed whilst on a three-year pre-registration Mental Health Nursing programme. The study was carried out in two university nursing schools in the South East of England and this paper reports a detailed analysis of 6 individual case studies. The researchers utilised Novak’s approach to concept mapping to elicit students’ personal knowledge structures, which were explored further using semi-struc...

  16. Longitudinal MRI studies of brain morphometry

    Skimminge, Arnold Jesper Møller

    the accompanying deformation field. Deformation fields from high dimensional warping founds tensor based morphometry (TBM), and provides unique opportunities to study human brain morphology and plasticity. In this thesis, specially adapted image processing streams utilizing several image registration......High resolution MR images acquired at multiple time points of the brain allow quantification of localized changes induced by external factors such as maturation, ageing or disease progression/recovery. High-dimensional warping of such MR images incorporates changes induced by external factors into...

  17. A CAD-CAM-prototyped temporomandibular condyle connected to a bony plate to support a free fibula flap in patients undergoing mandiblectomy: A pilot study with 5 years of follow up.

    Ciocca, Leonardo; Tarsitano, Achille; Marchetti, Claudio; Scotti, Roberto

    2016-07-01

    Reconstruction of the condyle after an ablative procedure with the aim of cancer elimination remains surgically challenging. This pilot study focused on mandibular condylar replacement using CAD-CAM temporomandibular prostheses connected to customized reconstructive plates to support free fibula flaps in oncological patients. Five patients underwent mandibular disarticulation resection, and two of them completed their 5-year follow ups. The condylar anatomy, the position of the condyle within the glenoid fossa, and glenoid anatomy were measured by superimposing pre- and postoperative CT images (obtained after 6 months and 5 years of follow up). When comparing condyle anatomy, the shift was no more than 0.19 mm; when calculating condyle downward displacement the values were inferior to 2.92 mm; when analyzing glenoid fossa thickness, in case #1, glenoid fossa thickness increased by 0.62 and 0.48 mm at the 6-month and 5-year follow ups, respectively, and in case #2 were 0.50 and -0.11 mm, respectively. The hypothesis that the absence of anatomical change would prevent biodynamic alteration of tissues of the articulation chamber (the glenoid fossa, the synovial liquid, and the disc) was confirmed by the preliminary findings of this study. PMID:27235153

  18. Urinary phthalates from 168 girls and boys measured twice a year during a 5-year period

    Mouritsen, A; Frederiksen, H; Sørensen, K;

    2013-01-01

    . Methods: This was a longitudinal study of 168 healthy children (84 girls) examined every 6 months for 5 years. Serum levels of dehydroepiandrostenedione sulfate (DHEAS), Δ4-androstenedione, testosterone, and urinary morning excretion of 14 phthalate metabolites, corresponding to 7 different phthalate......Background: Little is known about the possible deleterious effects of phthalate exposure on endogenous sex steroid levels in children. Objective: Our objective was to investigate whether urinary phthalate metabolite levels are associated with circulating adrenal androgen levels and age at puberty...

  19. A Longitudinal Study of Uremic Pruritus in Hemodialysis Patients

    Mathur, Vandana S.; Lindberg, Jill; Germain, Michael; Block, Geoffrey; Tumlin, James; Smith, Mark; Grewal, Mandeep; McGuire, Dawn

    2010-01-01

    Background and objectives: Although uremic pruritus (UP) is a highly prevalent complication of chronic kidney disease, it remains poorly characterized. There have been no longitudinal studies of natural history, and no health-related quality of life (HR-QOL) instruments have been developed for UP. The objectives of this study were to describe the natural history of UP, to compare rating scales of itching intensity, and to assess usefulness and validity of HR-QOL instruments for UP.

  20. Marital status and suicide in the National Longitudinal Mortality Study

    Kposowa, A.

    2000-01-01

    OBJECTIVES—The purpose of the study was to examine the effect of marital status on the risk of suicide, using a large nationally representative sample. A related objective was to investigate the association between marital status and suicide by sex.
METHODS—Cox proportional hazards regression models were applied to data from the National Longitudinal Mortality Study, based on the 1979-1989 follow up. In estimating the effect of marital status, adjustments were made for age, sex, race, educati...

  1. Visual Impairment, Hearing Loss and Cognitive Function in an Older Population: Longitudinal Findings from the Blue Mountains Eye Study

    Hong, Thomas; Mitchell, Paul; Burlutsky, George; Liew, Gerald; Wang, Jie Jin

    2016-01-01

    The presence of visual impairment (VI) and hearing loss (HL) with may be a marker for subsequent cognitive decline over time in older people. A prospective, longitudinal population-based study of the 3654 participants of the Blue Mountains Eye Study were assessed for the associations between VI and HL and a decline in mini-mental state examination (MMSE) scores over a duration of 10 years from the 5-year (baseline of this report) to the 15-year follow-up visits. MMSE was assessed at the 5-, 1...

  2. Cohort Profile: Footprints in Time, the Australian Longitudinal Study of Indigenous Children.

    Thurber, Katherine A; Banks, Emily; Banwell, Cathy

    2015-06-01

    Indigenous Australians experience profound levels of disadvantage in health, living standards, life expectancy, education and employment, particularly in comparison with non-Indigenous Australians. Very little information is available about the healthy development of Australian Indigenous children; the Longitudinal Study of Indigenous Children (LSIC) is designed to fill this knowledge gap.This dataset provides an opportunity to follow the development of up to 1759 Indigenous children. LSIC conducts annual face-to-face interviews with children (aged 0.5-2 and 3.5-5 years at baseline in 2008) and their caregivers. This represents between 5% and 10% of the total population of Indigenous children in these age groups, including families of varied socioeconomic and cultural backgrounds. Study topics include: the physical, social and emotional well-being of children and their caregivers; language; culture; parenting; and early childhood education.LSIC is a shared resource, formed in partnership with communities; its data are readily accessible through the Australian Government Department of Social Services (see http://dss.gov.au/lsic for data and access arrangements). As one of very few longitudinal studies of Indigenous children, and the only national one, LSIC will enable an understanding of Indigenous children from a wide range of environments and cultures. Findings from LSIC form part of a growing infrastructure from which to understand Indigenous child health. PMID:25011454

  3. Moderate agreement between body mass index and measures of waist circumference in the identification of overweight among 5-year-old children; the ‘Be active, eat right’ study

    Veldhuis, Lydian; Vogel, Ineke; Jansen, Wilma; Renders, Carry M; Hirasing, Remy A.; Raat, Hein

    2013-01-01

    Background Body mass index (BMI) is a common indirect method to assess weight status among children. There is evidence that BMI data alone can underestimate overweight-related health risk and that waist circumference (WC) should also be measured. In this study we investigated the agreement between BMI and WC and BMI and the waist-height ratio (WHtR) when used to identify overweight among children. Methods This cross-sectional population-based study uses baseline data from 5-year-olds (n = 770...

  4. Parent-Offspring Similarity for Drinking: A Longitudinal Adoption Study

    McGue, Matt; Malone, Steve; Keyes, Margaret; Iacono, William G.

    2014-01-01

    Parent-offspring resemblance for drinking was investigated in a sample of 409 adopted and 208 non-adopted families participating in the Sibling Interaction and Behavior Study (SIBS). Drinking data was available for 1229 offspring, assessed longitudinally up to three times in the age range from 10 to 28 years. A single drinking index was computed from four items measuring quantity, frequency and density of drinking. As expected, the mean drinking index increased with age, was greater in males ...

  5. Skin Conductance Fear Conditioning Impairments and Aggression: A Longitudinal Study

    Gao, Yu; Tuvblad, Catherine; Schell, Anne; Baker, Laura; Raine, Adrian

    2014-01-01

    Autonomic fear conditioning deficits have been linked to child aggression and adult criminal behavior. However, it is unknown if fear conditioning deficits are specific to certain subtypes of aggression, and longitudinal research is rare. In the current study, reactive and proactive aggression were assessed in a sample of males and females when aged 10, 12, 15, and 18 years old. Skin conductance fear conditioning data were collected when they were 18 years old. Individuals who were persistent...

  6. Weaving leadership longitudinally: a qualitative study on faculty development

    Joyce, Pauline

    2015-01-01

    Purpose The purpose of this study was to explore if faculty who undertake teacher preparation, which has a leadership intervention across each module, are better prepared to take on educational leadership roles. Methods A cross sectional qualitative approach was used as part of a longitudinal evaluation of a program. The aim was to explore the perceptions of a purposive sample across three cohorts of students. Data was collected via semi-structured interviews and were analyzed by thema...

  7. Health behaviors, affect, and academic performance : three longitudinal studies

    Flückiger, Lavinia Heidy

    2015-01-01

    Objective: Health behaviors are a fundamental and highly fluctuating component of everyday life. Evidence capturing these natural daily fluctuations is limited. Therefore, this dissertation investigates how these daily dynamics in health behaviors are associated with other important aspects of young adults’ everyday lives and bridges separate research strands by integrating health behaviors, affect, stress, and academic performance in three intensive longitudinal studies. Method: These three ...

  8. QOLOP: Quality of Life Longitudinal Study of Paediatric Oncology Patients

    Koutná, Veronika; Blažková, T.; Blatný, Marek; Kepák, T.; Jelínek, Martin

    Vol. 24. Hoboken: WILEY-BLACKWELL, 2015. s. 260-261. ISSN 1057-9249. [World Congress of Psycho - Oncology . 28.07.2015-01.08.2015, Washington, DC] R&D Projects: GA ČR(CZ) GAP407/11/2421 Institutional support: RVO:68081740 Keywords : quality of life * childhood cancer survivors * longitudinal study Subject RIV: AN - Psycho logy http://onlinelibrary.wiley.com/doi/10.1002/pon.3874/epdf

  9. Phenol Reduces Hypertonia and Enhances Strength: A Longitudinal Case Study

    McCrea, Patrick H; Eng, Janice J.; Willms, Rhonda

    2004-01-01

    Phenyl alcohol blocks are used to relieve spasticity. Such nerve conduction blocks result from phenol-induced axonotmesis and could potentially affect muscle properties related to the ability to generate, maximize, and reduce force. This study assessed the 12-week longitudinal effect of phenol on position (stiffness) and velocity (damping) components of hypertonia, in addition to strength (peak torque and times to generate and reduce torque) in an individual with chronic elbow flexor spastici...

  10. Longitudinal study on reciprocity between personality traits and parenting stress

    Rantanen, Johanna; Tillemann, Kati; Metsäpelto, Riitta-Leena; Kokko, Katja; Pulkkinen, Lea

    2014-01-01

    Reciprocal associations between the Big Five personality traits and parenting stress—including both parents’ feelings of their distress and perception of their incompetence as parents—were studied with 248 participants (49% of which were males). Longitudinal data, collected at ages 33/36, 42 and 50 years, were used. Cross-lagged path analysis revealed that in case of both mothers and fathers, neuroticism at age 33 predicted high parenting stress, and extraversion at age 33 predicted low paren...

  11. QOLOP: Quality of Life Longitudinal Study of Paediatric Oncology Patients

    Koutná, Veronika; Blažková, T.; Blatný, Marek; Kepák, T.; Jelínek, Martin

    Vol. 24. Hoboken : WILEY-BLACKWELL, 2015. s. 260-261. ISSN 1057-9249. [World Congress of Psycho-Oncology. 28.07.2015-01.08.2015, Washington, DC] R&D Projects: GA ČR(CZ) GAP407/11/2421 Institutional support: RVO:68081740 Keywords : quality of life * childhood cancer survivors * longitudinal study Subject RIV: AN - Psychology http://onlinelibrary.wiley.com/doi/10.1002/pon.3874/epdf

  12. The first 5 years after the dissertation.

    Hodges, L C; Poteet, G W

    1992-01-01

    To succeed in academia, nursing faculty members must devote the first 5 years following the dissertation to achieving a standard to tenure characteristic of the profession. Most institutions in the country adhere to the American Association of University Professors' guidelines for tenure. These guidelines mandate excellence in teaching, scholarship, and service. A fourth characteristic, leadership, is increasingly considered in tenure decisions. The expectations of an academic career in nursing serve as the foundation for a framework to evaluate the likelihood of success in a particular setting. A detailed 5-year plan for achieving tenure is proposed. PMID:1634654

  13. Influence of Maternal and Child Lifestyle-Related Characteristics on the Socioeconomic Inequality in Overweight and Obesity among 5-year-old Children; The “Be Active, Eat Right” Study

    Lydian Veldhuis

    2013-06-01

    Full Text Available It is unclear whether the socioeconomic inequality in prevalence of overweight and obesity is already present among very young children. This study investigates the association between overweight and socioeconomic status (SES, with maternal educational level as an indicator of SES among 5-year-old children. This cross-sectional study uses baseline data from 5-year-olds of Dutch ethnicity (n = 5,582 and their mothers collected for the “Be active, eat right” study. Compared to children of mothers with the highest educational level, for children of mothers with the lowest educational level the odds ratio (adjusted for demographic characteristics for having overweight was 2.10 (95% confidence interval: 1.57–2.82, and for having obesity was 4.18 (95% confidence interval: 2.32–7.55. Addition of maternal and child lifestyle-related characteristics decreased the odds ratios for overweight and obesity by 26.4% and 42.1%, respectively. The results show that an inverse SES-overweight/obesity association is already present at elementary school entry, and that watching TV by mother and child, the child consuming breakfast and, especially maternal weight status, are contributing factors in this association. These results should be taken into account when developing policies to reduce inequalities in (childhood health.

  14. Predicting Risk of Motor Vehicle Collisions in Patients with Glaucoma: A Longitudinal Study.

    Carolina P B Gracitelli

    Full Text Available To evaluate the ability of longitudinal Useful Field of View (UFOV and simulated driving measurements to predict future occurrence of motor vehicle collision (MVC in drivers with glaucoma.Prospective observational cohort study.117 drivers with glaucoma followed for an average of 2.1 ± 0.5 years.All subjects had standard automated perimetry (SAP, UFOV, driving simulator, and cognitive assessment obtained at baseline and every 6 months during follow-up. The driving simulator evaluated reaction times to high and low contrast peripheral divided attention stimuli presented while negotiating a winding country road, with central driving task performance assessed as "curve coherence". Drivers with MVC during follow-up were identified from Department of Motor Vehicle records.Survival models were used to evaluate the ability of driving simulator and UFOV to predict MVC over time, adjusting for potential confounding factors.Mean age at baseline was 64.5 ± 12.6 years. 11 of 117 (9.4% drivers had a MVC during follow-up. In the multivariable models, low contrast reaction time was significantly predictive of MVC, with a hazard ratio (HR of 2.19 per 1 SD slower reaction time (95% CI, 1.30 to 3.69; P = 0.003. UFOV divided attention was also significantly predictive of MVC with a HR of 1.98 per 1 SD worse (95% CI, 1.10 to 3.57; P = 0.022. Global SAP visual field indices in the better or worse eye were not predictive of MVC. The longitudinal model including driving simulator performance was a better predictor of MVC compared to UFOV (R2 = 0.41 vs R2 = 0.18.Longitudinal divided attention metrics on the UFOV test and during simulated driving were significantly predictive of risk of MVC in glaucoma patients. These findings may help improve the understanding of factors associated with driving impairment related to glaucoma.

  15. Whole grain intake: The Baltimore Longitudinal Study of Aging

    Maras, Janice E.; Newby, P.K.; Bakun, Peter J.; Ferrucci, Luigi; Tucker, Katherine L.

    2009-01-01

    Our objective was to identify major dietary sources of whole grains and to describe the construction of a database of whole grain content of foods. Dietary information was collected with 7-d food records from men and women in the Baltimore Longitudinal Study of Aging, mean age 62.1 ± 16.0 years, who participated in the dietary assessment portion of the study (n = 1516), and estimates of whole grain intake were obtained from a newly developed database. The Pyramid Servings database and 1994–19...

  16. Study of longitudinal dynamics in space-charge dominated beams

    Tian, Kai

    Modern accelerator applications, such as heavy ion fusion drivers, pulsed neutron sources, electron injectors for high-energy linear colliders, and X-ray Free Electron Lasers, demand beams with high intensity, low emittance and small energy spread. At low (non-relativistic) energies, the "electrostatic", collective interactions from space-charge forces existing in such intense beams play the dominant role; we characterize these beams as space-charge dominated beams. This dissertation presents numerous new findings on the longitudinal dynamics of a space-charge dominated beam, particularly on the propagation of density perturbations. In order to fully understand the complex physics of longitudinal space-charge waves, we combine the results of theory, computer simulation, and experiment. In the Long Solenoid Experimental system (LSE), with numerous diagnostic tools and techniques, we have, for the first time, experimentally measured the detailed energy profiles of longitudinal space-charge waves at different locations, both near the beam source and at the end of the transport system. Along with the current profiles, we have a complete set of experimental data for the propagation of space-charge waves. We compare these measured results to a 1-D theory and find better agreement for beams with perturbations in the linear regime, where the perturbation strength is less than 10%, than those with nonlinear perturbations. Using fast imaging techniques that we newly developed, we have, for the first time, obtained the progressive time-resolved images of longitudinal slices of a space-charge dominated beam. These images not only provide us time-resolved transverse density distribution of the beam, but also enable us to take time-resolved transverse phase space measurement using computerized tomography. By combining this information with the longitudinal energy measurement, we have, for the first time, experimentally constructed the full 6-D phase space. Part of the results

  17. Integrating Prospective Longitudinal Data: Modeling Personality and Health in the Terman Life Cycle and Hawaii Longitudinal Studies

    Kern, Margaret L.; Hampson, Sarah E.; Goldberg, Lewis R.; Friedman, Howard S.

    2014-01-01

    The present study used a collaborative framework to integrate 2 long-term prospective studies: the Terman Life Cycle Study and the Hawaii Personality and Health Longitudinal Study. Within a 5-factor personality-trait framework, teacher assessments of child personality were rationally and empirically aligned to establish similar factor structures…

  18. Cohort profile: the English longitudinal study of ageing.

    Steptoe, Andrew; Breeze, Elizabeth; Banks, James; Nazroo, James

    2013-12-01

    The English Longitudinal Study of Ageing (ELSA) is a panel study of a representative cohort of men and women living in England aged ≥50 years. It was designed as a sister study to the Health and Retirement Study in the USA and is multidisciplinary in orientation, involving the collection of economic, social, psychological, cognitive, health, biological and genetic data. The study commenced in 2002, and the sample has been followed up every 2 years. Data are collected using computer-assisted personal interviews and self-completion questionnaires, with additional nurse visits for the assessment of biomarkers every 4 years. The original sample consisted of 11 391 members ranging in age from 50 to 100 years. ELSA is harmonized with ageing studies in other countries to facilitate international comparisons, and is linked to financial and health registry data. The data set is openly available to researchers and analysts soon after collection (http://www.esds.ac.uk/longitudinal/access/elsa/l5050.asp). PMID:23143611

  19. Evidence of functional declining and global comorbidity measured at baseline proved to be the strongest predictors for long-term death in elderly community residents aged 85 years: a 5-year follow-up evaluation, the OCTABAIX study

    Formiga F

    2016-04-01

    Full Text Available Francesc Formiga,1,2 Assumpta Ferrer,3 Gloria Padros,4 Abelardo Montero,1,2 Carme Gimenez-Argente,1 Xavier Corbella1,2,5 On behalf of the Octabaix study members 1Internal Medicine Department, Geriatric Unit, Hospital Universitari de Bellvitge, Institut Català de la Salut, 2Bellvitge Biomedical Research Institute, IDIBELL, L’Hospitalet de Llobregat, 3Primary Care Centre “El Plà”, Direcció d’Atenció Primària Costa de Ponent, Institut Català de la Salut, Sant Feliu de Llobregat, 4South Metropolitan Clinical Laboratory, Direcció d’Atenció Primària Costa de Ponent, Institut Català de la Salut, L’Hospitalet de Llobregat, 5Albert J Jovell Institute of Public Health and Patients, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain Objective: To investigate the predictive value of functional impairment, chronic conditions, and laboratory biomarkers of aging for predicting 5-year mortality in the elderly aged 85 years.Methods: Predictive value for mortality of different geriatric assessments carried out during the OCTABAIX study was evaluated after 5 years of follow-up in 328 subjects aged 85 years. Measurements included assessment of functional status comorbidity, along with laboratory tests on vitamin D, cholesterol, CD4/CD8 ratio, hemoglobin, and serum thyrotropin.Results: Overall, the mortality rate after 5 years of follow-up was 42.07%. Bivariate analysis showed that patients who survived were predominantly female (P=0.02, and they showed a significantly better baseline functional status for both basic (P<0.001 and instrumental (P<0.001 activities of daily living (Barthel and Lawton index, better cognitive performance (Spanish version of the Mini-Mental State Examination (P<0.001, lower comorbidity conditions (Charlson (P<0.001, lower nutritional risk (Mini Nutritional Assessment (P<0.001, lower risk of falls (Tinetti gait scale (P<0.001, less percentage of heart failure (P=0

  20. Soviet business chaos seen lasting 5 years

    This paper reports that companies seeking work in the collapsing Soviet Union can expect political uncertainty for another 5 years. PW discussed changes in the Soviet Union and offered advice on dealing with officials of the central government and Soviet republics at a recent meeting in Houston with executives of oil field service companies. That meeting preceded reports of the Russian federation, Ukraine, and Byelorussia agreeing to form a Slavic commonwealth

  1. Histo-topographic study of the longitudinal anal muscle.

    Macchi, Veronica; Porzionato, Andrea; Stecco, Carla; Vigato, Enrico; Parenti, Anna; De Caro, Raffaele

    2008-07-01

    The longitudinal anal muscle (LAM) has been described as a vertical layer of muscular tissue interposed between the circular layers of the internal (IAS) and external (EAS) anal sphincters. There is, however, no general agreement in the literature on its composition and attachments. The aim of this study was to investigate the histological structure, attachments, and topography of the LAM in order to evaluate its role in continence and defecation, thus enhancing knowledge of the surgical anatomy of this region. After in situ formalin fixation, the pelvic viscera were removed from eight male and eight female cadavers (age range: 52-72 years). Serial macrosections of the bladder base, lower rectum and anal canal, cervix and pelvic floor complex, cut in the transverse (six specimens) and coronal (six specimens) planes, underwent histological and immunohistochemical studies. Four specimens were studied using the E12 sheet plastination technique. The LAM was identified in 10/12 specimens (83%). Transverse and coronal sections made clear that it is a longitudinal layer of muscular tissue, marking the boundary between the internal and external anal sphincters. From the anorectal junction it extends along the anal canal, receives fibers from the innermost part of the puborectalis and the puboanalis muscles, and terminates with seven to nine fibro-elastic septa, which traverse the subcutaneous part of the external anal sphincter, reaching the perianal dermis. In the transverse plane, the mean thickness of the LAM was 1.68 +/- 0.27 mm. Immunohistochemical staining showed that the LAM consists of predominantly outer striated muscle fibers and smaller numbers of inner smooth muscle fibers, respectively coming from the levator ani muscle and from the longitudinal muscular layer of the rectum. The oblique fibers suggest that the LAM may represent the intermediate longitudinal course of small bridging muscle bundles going reciprocally from the striated EAS to the smooth IAS and

  2. Secondary Science Teachers' Beliefs and Persistence: A Longitudinal Mixed-Methods Study

    Wong, Sissy S.; Luft, Julie A.

    2015-11-01

    While many studies focus on why teachers leave the classroom, there remains a need to study why teachers persist in teaching. One area to study is the beliefs of teachers, which may impact persistence in the field. This 5-year mixed-methods study explored whether 35 beginning secondary science teachers' beliefs were related to their persistence in teaching. Quantitative analysis of the teachers' responses to annual semi-structured interviews revealed that teachers with more student-centered beliefs were more likely to persist at the end of the third year of teaching. Additionally, the teaching beliefs of teachers were more teacher-centered, while the learning beliefs of teachers were more student-centered. A case study of one persisting teacher and one non-persisting teacher revealed that personal experiences and knowledge impacted beliefs about teaching and learning. Bruce, who had extensive inquiry-based school experiences, believed in teaching via student-centered methods. Oscar, who underwent mostly direct instruction during his school experiences, believed in teacher-centered instruction and focused on classroom management. This longitudinal study contributes to the field of science education by examining beginning secondary science teacher persistence over time. Implications from this study call for challenging teacher beliefs during the induction period, proper placement of new teachers into their first teaching positions, and understanding the impact of prior experiences on teachers' beliefs.

  3. "Old Age and Loneliness: Cross-Sectional and Longitudinal Analyses in the Tampere Longitudinal Study on Aging"

    Jylha, Marja

    2004-01-01

    The purpose of this study was to examine whether older age is associated with increasing loneliness in people aged 60 and over. Data came from TamELSA, a population-based prospective longitudinal study in Tampere, Finland. The followup time was 20 years. Loneliness was measured by a single question--"Do you feel lonely?"--with the possible answers…

  4. Insight dimensions and cognitive function in psychosis: a longitudinal study

    Peralta Victor

    2006-05-01

    Full Text Available Abstract Background It has been reported that lack of insight is significantly associated with cognitive disturbance in schizophrenia. This study examines the longitudinal relationships between insight dimensions and cognitive performance in psychosis. Methods Participants were 75 consecutively admitted inpatients with schizophrenia, affective disorder with psychotic symptoms or schizoaffective disorder. Assessments were conducted at two time points during the study: at the time of hospital discharge after an acute psychotic episode and at a follow-up time that occurred more than 6 months after discharge. A multidimensional approach of insight was chosen and three instruments for its assessment were used: the Scale to Assess Unawareness of Mental Disorder (SUMD, three items concerning insight on the Assessment and Documentation in Psychopathology (AMDP system and the Insight and Treatment Attitudes Questionnaire. The neuropsychological battery included a wide range of tests that assessed global cognitive function, attention, memory, and executive functions. Results After conducting adequate statistical correction to avoid Type I bias, insight dimensions and cognitive performance were not found to be significantly associated at cross-sectional and longitudinal assessments. In addition, baseline cognitive performance did not explain changes in insight dimensions at follow-up. Similar results were found in the subset of patients with schizophrenia (n = 37. The possibility of a Type II error might have increased due to sample attrition at follow-up. Conclusion These results suggest that lack of insight dimensions and cognitive functioning may be unrelated phenomena in psychosis.

  5. A longitudinal study of memory advantages in bilinguals.

    Jessica K Ljungberg

    Full Text Available Typically, studies of cognitive advantages in bilinguals have been conducted previously by using executive and inhibitory tasks (e.g. Simon task and applying cross-sectional designs. This study longitudinally investigated bilingual advantages on episodic memory recall, verbal letter and categorical fluency during the trajectory of life. Monolingual and bilingual participants (n=178 between 35-70 years at baseline were drawn from the Betula Prospective Cohort Study of aging, memory, and health. Results showed that bilinguals outperformed monolinguals at the first testing session and across time both in episodic memory recall and in letter fluency. No interaction with age was found indicating that the rate of change across ages was similar for bilinguals and monolinguals. As predicted and in line with studies applying cross-sectional designs, no advantages associated with bilingualism were found in the categorical fluency task. The results are discussed in the light of successful aging.

  6. Longitudinal bunch dynamics study with coherent synchrotron radiation

    Billinghurst, B. E.; Bergstrom, J. C.; Baribeau, C.; Batten, T.; May, T. E.; Vogt, J. M.; Wurtz, W. A.

    2016-02-01

    An electron bunch circulating in a storage ring constitutes a dynamical system with both longitudinal and transverse degrees of freedom. Through a self-interaction with the wakefields created by the bunch, certain of these degrees may get excited, defining a set of eigenmodes analogous to a spectroscopic series. The present study focuses on the longitudinal modes of a single bunch. The excitation of a mode appears as an amplitude modulation at the mode frequency of the coherent synchrotron radiation (CSR) emitted by the bunch. The modulations are superimposed on a much larger continuum from CSR emission in the continuous mode. A given eigenmode is classified by the integer m which is the ratio of the mode frequency to the synchrotron frequency. The present measurements extend up to m =8 and focus on the region near the instability thresholds. At threshold the modes are excited sequentially, resembling a staircase when the mode frequencies are plotted as a function of bunch length or synchrotron frequency. Adjacent modes are observed to coexist at the boundaries between the modes. An energy-independent correlation is observed between the threshold current for an instability and the corresponding zero-current bunch length. Measurements were made at five beam energies between 1.0 and 2.9 GeV at the Canadian Light Source. The CSR was measured in the time domain using an unbiased Schottky diode spanning 50-75 GHz.

  7. Longitudinal Study: Efficacy of Online Technology Tools for Instructional Use

    Uenking, Michael D.

    2011-01-01

    Studies show that the student population (secondary and post secondary) is becoming increasingly more technologically savvy. Use of the internet, computers, MP3 players, and other technologies along with online gaming has increased tremendously amongst this population such that it is creating an apparent paradigm shift in the learning modalities of these students. Instructors and facilitators of learning can no longer rely solely on traditional lecture-based lesson formals. In order to achieve student academic success and satisfaction and to increase student retention, instructors must embrace various technology tools that are available and employ them in their lessons. A longitudinal study (January 2009-June 2010) has been performed that encompasses the use of several technology tools in an instructional setting. The study provides further evidence that students not only like the tools that are being used, but prefer that these tools be used to help supplement and enhance instruction.

  8. Father involvement in infant care: two longitudinal studies.

    Rustia, J G; Abbott, D

    1993-12-01

    Data collected from two samples of fathers in separate longitudinal studies were compared. One sample consisted of 53 first-time fathers and the other of 69 multiple-time fathers. A post-test only time-series design was used for both studies, and both employed the same procedures and instruments. The studies examined role enactment of fathers with different child-caring experiences using role-theory concepts. Fathers' normative expectations, personal expectations, and personal learning about parenting were tested to determine if they were predictive of paternal role performance. The findings seem to indicate that the culture of fatherhood has changed more rapidly than the conduct of fatherhood. PMID:8288416

  9. A Longitudinal Examination of Childhood Maltreatment and Adolescent Obesity: Results from the National Longitudinal Study of Adolescent Health (AddHealth) Study

    Shin, Sunny Hyucksun; Miller, Daniel P.

    2012-01-01

    Objectives: We sought to explore the association between childhood maltreatment (e.g., neglect, physical and sexual abuse) and longitudinal growth trajectories of body mass index (BMI) from adolescence to young adulthood. Methods: We used latent curve modeling to examine data from the National Longitudinal Study of Adolescent Health (N = 8,471),…

  10. Assessment of caries prevalence among children below 5 years old

    Prabhu, Poornima; Rajajee, K. T. S. S.; Sudheer, K. A.; Jesudass, G.

    2014-01-01

    Context: In the current scenario of developing countries, dental caries has been a long-standing challenge in the oral health issue and still on the rise. Aim: The aim of the following study is to estimate the caries prevalence in the primary dentition among children below 5 years of age. Meterials and Methods: Study population included both boys and girls below 5 years old attending KGF Dental College and Hospital, Karnataka. A simple random sampling method was used. A total of 672 children ...

  11. Impedance studies for the PS Finemet loaded longitudinal damper

    Persichelli, S; Paoluzzi, M; Salvant, B

    2014-01-01

    The impedance of the Finemet® loaded longitudinal damper cavity, installed in the CERN Proton Synchrotron straight section 02 during the Long Shutdown 2013-2014, has been evaluated [1]. Time domain simulations with CST Particle Studio have been performed in order to get the longitudinal and transverse impedance of the device and make a comparison with the longitudinal impedance that was measured for a single cell prototype.

  12. A longitudinal study of back dimension changes over 1 year in sports horses.

    Greve, Line; Dyson, Sue

    2015-01-01

    Major back dimension changes over time have been observed in some horses, the speed of which may be influenced by work type, skeletal maturity, nutrition and saddle fit. Currently, there are no longitudinal data quantifying changes in back dimensions. The objectives of this study were to quantify back dimension changes over time, to identify the effects of horse, saddle and rider on these dimensions, and to determine their association with season, weight, work and saddle management. A prospective, longitudinal study was performed, using stratified random sampling within a convenience sample of 104 sports horses in normal work. Thoracolumbar dimensions/symmetry were measured at predetermined sites every second month over 1 year; weight, work and saddle management changes were recorded. Descriptive statistics, and univariable and multiple mixed effects linear regression were performed to assess the association between management changes, horse-saddle-rider factors and back dimension changes. Complete data was available for 63/104 horses, including horses used for dressage (n= 26), showjumping (n= 26), eventing (n= 26) and general purpose (n= 26), with age groups 3-5 years (n = 24), 6-8 years (n = 28), 9-12 years (n = 24) and ≥ 13 years (n = 28). There were considerable variations in back dimensions over 1 year. In the multivariable analysis, the presence of gait abnormalities at initial examination and back asymmetry were significant and had a negative effect on changes in back dimensions. Subsequent improved saddle fit, similar or increased work intensity, season (summer versus winter) and increased bodyweight retained significance, having positive effects on changes in back dimensions. In conclusion, quantifiable changes in back dimensions occur throughout the year. Saddle fit should be reassessed professionally several times a year, especially if there has been a change in work intensity. PMID:25510314

  13. Hearing loss in the Royal Norwegian Navy: A longitudinal study.

    Irgens-Hansen, Kaja; Baste, Valborg; Bratveit, Magne; Lind, Ola; Koefoed, Vilhelm F; Moen, Bente E

    2016-01-01

    The aims of this longitudinal study were to investigate a significant threshold shift (STS) among personnel working on board the Royal Norwegian Navy's (RNoN) vessels between 2012 and 2014 and to identify possible determinants of STS. Hearing thresholds were measured by pure tone audiometry in two consecutive examinations (n = 226). STS was defined as an average change in hearing thresholds ≥ + 10 dB at 2,000 Hz, 3,000 Hz, and 4,000 Hz in either ear. Determinants of STS were assessed through a questionnaire. The incidence of STS was 23.0%. Significant determinants of STS were the number of episodes of temporary threshold shifts (TTS) in the Navy, exposure to continuous loud noise during work on board, and the number of gun shots (in the Navy, hunting, and sports). This study indicated a significant association between noise exposure on board Navy vessels and development of STS. PMID:27157689

  14. A longitudinal study of adult foreign language learning

    Nielsen, Andreas Højlund; Horn, Nynne Thorup; Sørensen, Stine Derdau;

    Models of speech learning suggest that adaptations to foreign language sound categories should happen early in the acquisition process. Results from laboratory language training show effects on non-native perception within one to three weeks of training. Results from linguistic immersion studies...... show differences in adaptations when contrasting averages of 1-2 yrs of experience with 6-7 yrs of experience. We investigated this apparent discrepancy in a longitudinal study on Danish language officer cadets learning either Arabic (MSA and Egyptian dialect) or Dari (Afghan Farsi) through intensive...... multi-faceted language training. We conducted two experiments (identification and discrimination) with the two groups of cadets. The cadets were tested at four time points (at the start (T0), after three weeks (T1), after six months (T2), and after 20 months (T3)). We used a phonemic Arabic contrast...

  15. Hearing loss in the Royal Norwegian Navy: A longitudinal study

    Irgens-Hansen, Kaja; Baste, Valborg; Bråtveit, Magne; Lind, Ola; Koefoed, Vilhelm F.; Moen, Bente E

    2016-01-01

    The aims of this longitudinal study were to investigate a significant threshold shift (STS) among personnel working on board the Royal Norwegian Navy's (RNoN) vessels between 2012 and 2014 and to identify possible determinants of STS. Hearing thresholds were measured by pure tone audiometry in two consecutive examinations (n = 226). STS was defined as an average change in hearing thresholds ≥ + 10 dB at 2,000 Hz, 3,000 Hz, and 4,000 Hz in either ear. Determinants of STS were assessed through a questionnaire. The incidence of STS was 23.0%. Significant determinants of STS were the number of episodes of temporary threshold shifts (TTS) in the Navy, exposure to continuous loud noise during work on board, and the number of gun shots (in the Navy, hunting, and sports). This study indicated a significant association between noise exposure on board Navy vessels and development of STS. PMID:27157689

  16. Improving retention of very old participants in longitudinal research: experiences from the Newcastle 85+ study.

    Karen Davies

    Full Text Available BACKGROUND: People aged 85 and over are often excluded from research on the grounds of being difficult to recruit and problematic to retain. The Newcastle 85+ study successfully recruited a cohort of 854 85-year-olds to detailed health assessment at baseline and followed them up over 3 phases spanning 5 years. This paper describes the effectiveness of its retention strategies. METHODS: Primary retention strategies involved meticulous management of contact information and active maintenance of contact with participants between research visits and between phases of the study. For statistical analysis, data on post-inclusion attrition over the 3 follow-up phases was separated into 'death' and 'withdrawal' categories, with sub-categories 'health' and 'non-health' reasons created for 'withdrawal'. Multinomial logistic regression was used to determine if particular socio-demographic and health characteristics were associated with post-inclusion attrition due to withdrawal at each of the 3 phase-to-phase transition points. RESULTS: For both sexes, at successive follow-up phases there was a decrease in attrition due to withdrawal and an increase due to death. Withdrawal was most prevalent between baseline and phase 2. Across the 5 years of the study total post-inclusion (post-baseline attrition due to death accounted for a 40% (344/854 loss to cohort and total post-inclusion attrition due to withdraw a 19% (166/854 loss to cohort, with health reasons for withdrawal becoming more dominant over time. Adjusting for sex, parsimonious modelling showed only occupational class (National Statistics Socio-economic Classification to be associated with withdrawal and only between baseline and phase 2 (routine/manual compared to managerial (OR 3.41; 95% CI [1.23 to 9.44]. CONCLUSION: Following successful recruitment, we retained a high proportion of participants from a very old age group over 5 years of longitudinal research. No strong predictors of post

  17. A Longitudinal Adoption Study of Substance Use Behavior in Adolescence.

    Huibregtse, Brooke M; Corley, Robin P; Wadsworth, Sally J; Vandever, Joanna M; DeFries, John C; Stallings, Michael C

    2016-08-01

    Although cross-sectional twin studies have assessed the genetic and environmental etiologies of substance use during adolescence and early adulthood, comparisons of results across different samples, measures, and cohorts are problematic. While several longitudinal twin studies have investigated these issues, few corroborating adoption studies have been conducted. The current study is the first to estimate the magnitude of genetic, shared environmental, and non-shared environmental influences on substance use (cigarettes, alcohol, and marijuana) from ages 14 to 18 years, using a prospective longitudinal adoption design. Adoptive and control sibling correlations provided substantial evidence for early genetic effects on cigarette, alcohol, and marijuana use/no use. Shared environmental effects were relatively modest, except for alcohol use, which showed increases in late adolescence (age 17 to 18 years). Sibling similarity for quantity/frequency of use also support additive genetic influences across adolescence, with some shared environmental influences for all three substances. To test the stability of these influences across time, a series of independent pathway models were run to explore common and age-specific influences. For all substances, there were minimal age-specific additive genetic and shared environmental influences on quantity/frequency of use. Further, there was a trend toward increasing genetic influences on cigarette and alcohol use across ages. Genetic influences on marijuana were important early, but did not contribute substantially at age 17 and 18 years. Overall, the findings indicate that genetic influences make important contributions to the frequency/quantity of substance use in adolescence, and suggest that new genetic influences may emerge in late adolescence for cigarette and alcohol use. PMID:27161024

  18. Integrating Prospective Longitudinal Data: Modeling Personality and Health in the Terman Life Cycle and Hawaii Longitudinal Studies

    Kern, Margaret L.; Hampson, Sarah E.; Goldberg, Lewis R.; Friedman, Howard S.

    2012-01-01

    The present study used a collaborative framework to integrate two long-term prospective studies: the Terman Life Cycle Study and the Hawaii Personality and Health Longitudinal Study. Using a five-factor personality-trait framework, teacher assessments of child personality were rationally and empirically aligned to establish similar factor structures across samples. Comparable items related to adult self-rated health, education, and alcohol use were harmonized, and data were pooled on harmoniz...

  19. Metalinguistic awareness and early reading: a longitudinal study Metalinguistic awareness and early reading: a longitudinal study

    L. Van Damme

    2008-04-01

    Full Text Available This study originates from two 'ecologically valid' educational experiences. First, there is Van Damme's activity as a teacher-researcher in the RUG Laboratory of Education's experimental primary school. Since 1980 she has been responsible for the reading and writing program of the children of the 1st and 2nd grade (aged 6 - 8. Second, there is the preschool reading acquisition experience in which a father (M.Spoelders and his son joined efforts to make the 'miracle of literacy acquisition' happen(Spoelders & Van Damme, 1982. Both experiences convinced the writers of this paper that the phenomenon of developmental metalinguistics should be in the focus of their future educational and scientific endeavours. This study originates from two 'ecologically valid' educational experiences. First, there is Van Damme's activity as a teacher-researcher in the RUG Laboratory of Education's experimental primary school. Since 1980 she has been responsible for the reading and writing program of the children of the 1st and 2nd grade (aged 6 - 8. Second, there is the preschool reading acquisition experience in which a father (M.Spoelders and his son joined efforts to make the 'miracle of literacy acquisition' happen(Spoelders & Van Damme, 1982. Both experiences convinced the writers of this paper that the phenomenon of developmental metalinguistics should be in the focus of their future educational and scientific endeavours.

  20. Rationales, design and recruitment of the Taizhou Longitudinal Study

    Lu Daru

    2009-07-01

    Full Text Available Background Rapid economic growth in China in the past decades has been accompanied by dramatic changes in lifestyle and environmental exposures. The burdens of non-communicable diseases, such as cardiovascular diseases, diabetes and cancer, have also increased substantially. Methods/design We initiated a large prospective cohort–the Taizhou Longitudinal Study–in Taizhou (a medium-size city in China to explore the environmental and genetic risk factors for common non-communicable diseases. The sample size of the cohort will be at least 100,000 adults aged 30–80 years drawn from the general residents of the districts of Hailin, Gaogang, and Taixing (sample frame, 1.8 million of Taizhou. A three-stage stratified sampling method will be applied. Baseline investigations include interviewer-administered questionnaire, anthropometric measurements, and collection of buccal mucosal cells and blood specimens. DNA will be extracted for genetic studies and serum samples will be used for biochemical examinations. A follow-up survey will be conducted every three years to obtain information on disease occurrence and information on selected lifestyle exposures. Study participants will be followed-up indefinitely by using a chronic disease register system for morbidity and cause-specific mortality. Information on non-fatal events will be obtained for certain major categories of disease (e.g., cancer, stroke, myocardial infarction through established registry systems. Discussion The Taizhou Longitudinal Study will provide a good basis for exploring the roles of many important environmental factors (especially those concomitant with the economic transformation in China for common chronic diseases, solely or via interaction with genetic factors.

  1. Maternal Smoking during Pregnancy and DNA-Methylation in Children at Age 5.5 Years: Epigenome-Wide-Analysis in the European Childhood Obesity Project (CHOP)-Study

    Rzehak, Peter; Saffery, Richard; Reischl, Eva; Covic, Marcela; Wahl, Simone; Grote, Veit; Xhonneux, Annick; Langhendries, Jean-Paul; Ferre, Natalia; Closa-Monasterolo, Ricardo; Verduci, Elvira; Riva, Enrica; Socha, Piotr; Gruszfeld, Dariusz; Koletzko, Berthold

    2016-01-01

    Mounting evidence links prenatal exposure to maternal tobacco smoking with disruption of DNA methylation (DNAm) profile in the blood of infants. However, data on the postnatal stability of such DNAm signatures in childhood, as assessed by Epigenome Wide Association Studies (EWAS), are scarce. Objectives of this study were to investigate DNAm signatures associated with in utero tobacco smoke exposure beyond the 12th week of gestation in whole blood of children at age 5.5 years, to replicate previous findings in young European and American children and to assess their biological role by exploring databases and enrichment analysis. DNA methylation was measured in blood of 366 children of the multicentre European Childhood Obesity Project Study using the Illumina Infinium HM450 Beadchip (HM450K). An EWAS was conducted using linear regression of methylation values at each CpG site against in utero smoke exposure, adjusted for study characteristics, biological and technical effects. Methylation levels at five HM450K probes in MYO1G (cg12803068, cg22132788, cg19089201), CNTNAP2 (cg25949550), and FRMD4A (cg11813497) showed differential methylation that reached epigenome-wide significance according to the false-discovery-rate (FDR) criteria (q-valuechildhood phenotypes, previously associated with maternal smoking, requires further investigation. PMID:27171005

  2. Longitudinal study of serum placental GH in 455 normal pregnancies

    Chellakooty, Marla; Skibsted, Lillian; Skouby, Sven Olaf;

    2002-01-01

    Placental GH is thought to be responsible for the rise in maternal IGF-I during pregnancy and is considered to be important for fetal growth. In this prospective longitudinal study of healthy pregnant women, we investigated determinants of placental GH in maternal serum. Serum was obtained from 455...... women with normal singleton pregnancies at approximately 19 and 28 wk gestation. Serum placental GH concentrations were measured by a highly specific immunoradiometric assay, and fetal size was measured by ultrasound. Data on birth weight, gender, prepregnancy body mass index (BMI), parity, and smoking...... habits were obtained from medical records. Serum placental GH concentrations were detectable in serum from all women as early as 14 wk gestation and increased during pregnancy in all individuals (P <0.001). Placental GH levels at second examination were found to be higher in women carrying female fetuses...

  3. A Longitudinal Study of Hedges in Different Moves of EMRAs

    寇英

    2013-01-01

    This paper investigates the evolutionary change in the OF (OF) of hedges in different moves of EMRAs (EMRAs). Two corpora are established for longitudinal study, with Corpus A consisting of EMRAs from 1990-1994 and Corpus B from 2005-2009. Generally, no significant change has been found in overall use of hedges. However, apart from move 6, 7 and 10, we have found some interesting changes in the other moves. On the one hand, the OF of hedges in move 1, move 3, move 4 and move 5 shows a significant increase. On the other hand, the OF of hedges in move 2, 8, 9 and move 11 show a significant de⁃crease.

  4. Growth trajectories in the children of mothers with eating disorders: a longitudinal study

    Easter, A.; Howe, L D; Tilling, K; Schmidt, U.; Treasure, J.; Micali, N.

    2014-01-01

    Objective The aim of this study was to examine longitudinal patterns of growth trajectories in children of women with eating disorders (ED): anorexia nervosa (AN) and bulimia nervosa (BN). Design Prospective longitudinal birth cohort; Avon Longitudinal Study of Parents and Children (ALSPAC). Setting South West England, UK. Participants The sample consisted of women and their children (n=10 190) from ALSPAC. Patterns of growth among children of women reporting a history of AN (n=137), BN (n=16...

  5. A longitudinal study of rumination and distraction in formerly depressed inpatients and community controls.

    Huffziger, Silke; Reinhard, Iris; Kuehner, Christine

    2009-11-01

    The response styles theory (S. Nolen-Hoeksema, B. E. Wisco, & S. Lyubomirsky, 2008) supposes that ruminative coping is a cognitive risk factor for the course of depression, whereas distractive coping has protective effects. The authors present a longitudinal study on reciprocal relations between coping styles and depressive symptoms. They investigated 82 formerly depressed inpatients 4 weeks, 6 months, and 3.5 years after hospital discharge together with 76 age- and gender-matched community controls. Depressive symptoms predicted future symptom-focused rumination over the initial short-term interval in both samples. In former inpatients, this predictive effect was also significant over the subsequent long-term interval. Symptom-focused rumination and distraction were significant predictors of future depressive symptoms across both intervals, with sample-specific effects. In the community sample, symptom-focused rumination predicted more depressive symptoms, whereas in former inpatients, distractive coping predicted fewer depressive symptoms over time. The authors conclude that interventions aimed at reducing rumination should preferably be applied in preventive and early intervention settings, although in individuals with a history of more severe and long-standing depression rumination might gradually lose its capacity to predict the further illness course. In these persons, interventions should particularly strengthen distractive coping. PMID:19899844

  6. Progressive changes in arch width from primary to early mixed dentition period: A longitudinal study

    S Sangwan

    2011-01-01

    Full Text Available Objective: The present study was conducted to evaluate, on a longitudinal basis, the changes in intercanine and intermolar widths form the primary to the early mixed dentition periods. Materials and Methods: A total of 38 children aged 4-5 years, with normal occlusion without any proximal caries or any dental anomalies, were selected. The impressions were recorded and casts were prepared. Intercanine and intermolar widths were measured on these dental casts with the help of a digital vernier calliper. After 3 years follow-up, the impressions were recorded again and dental casts were prepared. Intercanine and intermolar widths were measured again at this stage and were compared with the baseline data using the paired t-test and the chi square test. Results: There is a significant increase in the intercanine (3.93 + 1.70 mm and intermolar width (1.49 + 1.77 mm during the transition period from primary to early mixed dentition in both the arches and both the sexes. The gender-wise comparison showed a greater increase in males than in females, but this was not statistically significant. Conclusion: A thorough knowledge of growth changes during various stages of the mixed dentition period are important for a pediatric dentist to make an accurate diagnosis and treatment planning during preventive and interceptive orthodontics.

  7. Maternal Smoking during Pregnancy and DNA-Methylation in Children at Age 5.5 Years: Epigenome-Wide-Analysis in the European Childhood Obesity Project (CHOP-Study.

    Peter Rzehak

    Full Text Available Mounting evidence links prenatal exposure to maternal tobacco smoking with disruption of DNA methylation (DNAm profile in the blood of infants. However, data on the postnatal stability of such DNAm signatures in childhood, as assessed by Epigenome Wide Association Studies (EWAS, are scarce. Objectives of this study were to investigate DNAm signatures associated with in utero tobacco smoke exposure beyond the 12th week of gestation in whole blood of children at age 5.5 years, to replicate previous findings in young European and American children and to assess their biological role by exploring databases and enrichment analysis. DNA methylation was measured in blood of 366 children of the multicentre European Childhood Obesity Project Study using the Illumina Infinium HM450 Beadchip (HM450K. An EWAS was conducted using linear regression of methylation values at each CpG site against in utero smoke exposure, adjusted for study characteristics, biological and technical effects. Methylation levels at five HM450K probes in MYO1G (cg12803068, cg22132788, cg19089201, CNTNAP2 (cg25949550, and FRMD4A (cg11813497 showed differential methylation that reached epigenome-wide significance according to the false-discovery-rate (FDR criteria (q-value<0.05. Whereas cg25949550 showed decreased methylation (-2% DNAm ß-value, increased methylation was observed for the other probes (9%: cg12803068; 5%: cg22132788; 4%: cg19089201 and 4%: cg11813497 in exposed relative to non-exposed subjects. This study thus replicates previous findings in children ages 3 to 5, 7 and 17 and confirms the postnatal stability of MYO1G, CNTNAP2 and FRMD4A differential methylation. The role of this differential methylation in mediating childhood phenotypes, previously associated with maternal smoking, requires further investigation.

  8. Connections between Learning Experience, Study Behaviour and Academic Performance: A Longitudinal Study

    Ning, H. K.; Downing, Kevin

    2010-01-01

    Background: Whilst past studies have established the joint influence of student learning experience and study behaviour on academic achievement, few attempts have been made to determine their causal ordering in a longitudinal framework. Purpose: This study explored the reciprocal relationship between learning experience and study behaviour, and…

  9. Parental influences on adolescent physical activity: a longitudinal study

    Ayala Guadalupe X

    2007-02-01

    Full Text Available Abstract Background Physical inactivity is increasing among adolescents in the U.S., especially among girls. Despite growing evidence that parents are an important influence on adolescent health, few longitudinal studies have explored the causal relationship between parental influence and physical activity. This study examines how the relationships between parental influences and adolescent physical activity differ by gender and tests whether these relationships are mediated by adolescents' self-esteem and depression. Methods Data are from the National Longitudinal Study of Adolescent Health. The sample includes 13,246 youth, grades 7 to 12, interviewed in 1995 and again 1 year later. Logit models were used to evaluate parental influences on achieving five or more bouts of moderate to vigorous physical activity per week [MVPA] and whether the relationship between parental influence and MVPA was mediated by adolescents' level of self-esteem and depression. Results Family cohesion, parent-child communication and parental engagement positively predicted MVPA for both genders one year later (odds ratios and 95% confidence intervals for females, 1.09 [1.05–1.12], 1.13 [1.07–1.19], 1.25 [1.17–1.33] and males, 1.08 [1.04–1.11], 1.14 [1.07–1.23], 1.23 [1.14–1.33], respectively; however, parental monitoring did not (odds ratio and confidence intervals for females and males, 1.02 [.97–1.07]. For both females and males, self-esteem mediated the relationship between parental influence and physical activity. Depressive symptoms were only a mediator among males. Females reported higher levels of parent-child communication and lower family cohesion compared with males. There were no gender differences in levels of parental monitoring and engagement. Females had significantly lower levels of self-esteem and higher levels of depressive symptoms than males. Conclusion Strategies to promote physical activity among adolescents should focus on

  10. Undergraduate nursing students' learning styles: a longitudinal study.

    Fleming, Sandra; McKee, Gabrielle; Huntley-Moore, Sylvia

    2011-07-01

    This paper reports on the main findings of a longitudinal study of the learning styles of one cohort of undergraduate pre-registration nursing students at an Irish university. The Honey and Mumford (2000a) Learning Styles Questionnaire was administered to a sample of students in their first (n=202) and final year of study (n=166), the final sample number (58) was based on matched pairs. The most common dominant learning style in first year was the dual learning category (35%) while a large proportion of the students (53%) in their final year had no dominant learning style. The preferred learning style of students in their first (69%) and final (57%) year was reflector. Learning styles were significantly different at the two time points and there was a significant relationship between some learning styles and students' age but not with academic achievement. Total scores of all learning styles showed significant improvements across the two time points of the study. An important implication for nurse education practice is the need for nurse educators to be aware of students' learning styles and in an attempt to maximise students' learning potential, utilise a range of teaching and learning methodologies and assessments that develop all learning styles. PMID:20863600

  11. Becoming a mental health nurse; A three year longitudinal study

    Harvey Wells

    2015-03-01

    Full Text Available This longitudinal case series study explores how students’ conceptions of ‘mental health nursing’ changed whilst on a three-year pre-registration Mental Health Nursing programme. The study was carried out in two university nursing schools in the South East of England and this paper reports a detailed analysis of 6 individual case studies. The researchers utilised Novak’s approach to concept mapping to elicit students’ personal knowledge structures, which were explored further using semi-structured individual qualitative interviews. The maps were analysed by looking at their gross morphology to interpret changes over time into types of learning achieved and the associated interview data were analysed using thematic content analysis. Results from analysis of the map structures suggest that whilst four of the selected students learned deeply, one participant learned superficially and one appeared not to learn at all. The associated interview data provides an interesting insight into the students’ reflective narratives on the process of learning. The findings also demonstrate further evidence of the practicability of using Novakian concept maps to self-prompt qualitative research interviews. Implications for the professional education of Mental Health Nurses are discussed.

  12. Longitudinal Trajectories in Guilford-Zimmerman Temperament Survey Data: Results from the Baltimore Longitudinal Study of Aging

    Terracciano, Antonio; McCrae, Robert R.; Costa, Paul T.

    2006-01-01

    Developmental trends in personality traits over 42 years were examined using data from the Baltimore Longitudinal Study on Aging (N = 2,359, aged 17 to 98), collected from 1958 to 2002. Hierarchical Linear Modeling analyses revealed cumulative mean-level changes averaging about 0.5 SD across adulthood. Scales related to Extraversion showed distinct developmental patterns: General Activity declined from age 60 to 90; Restraint increased; Ascendance peaked around age 60; and Sociability decline...

  13. Race, ideology, and the tea party: a longitudinal study.

    Eric D Knowles

    Full Text Available The Tea Party movement, which rose to prominence in the United States after the election of President Barack Obama, provides an ideal context in which to examine the roles of racial concerns and ideology in politics. A three-wave longitudinal study tracked changes in White Americans' self-identification with the Tea Party, racial concerns (prejudice and racial identification, and ideologies (libertarianism and social conservatism over nine months. Latent Growth Modeling (LGM was used to evaluate potential causal relationships between Tea Party identification and these factors. Across time points, racial prejudice was indirectly associated with movement identification through Whites' assertions of national decline. Although initial levels of White identity did not predict change in Tea Party identification, initial levels of Tea Party identification predicted increases in White identity over the study period. Across the three assessments, support for the Tea Party fell among libertarians, but rose among social conservatives. Results are discussed in terms of legitimation theories of prejudice, the "racializing" power of political judgments, and the ideological dynamics of the Tea Party.

  14. Medical Graduates, Tertiary Hospitals, and Burnout: A Longitudinal Cohort Study

    Parr, Justin M.; Pinto, Nigel; Hanson, Martin; Meehan, Ashlea; Moore, Peter T.

    2016-01-01

    Background: Burnout among junior doctors can affect patient care. We conducted a longitudinal cohort study designed to explore the incidence of burnout in medical interns and to examine the changes in burnout during the course of the intern year. Methods: Interns were recruited at two tertiary hospitals in Brisbane, Australia (n=180). Participants completed surveys at four time points during their internship year. All interns (100%) completed the baseline survey during their orientation. Response rates were 85%, 88%, and 79%, respectively, at 5-week, 6-month, and 12-month follow-up. Results: Interns reported high levels of personal and work-related burnout throughout the year that peaked at 6 months with mean scores of 42.53 and 41.81, respectively. Increases of 5.1 points (confidence interval [CI] 2.5,7.7; P=0.0001) and 3.5 points (CI 1.3,5.6; P=0.0015) were seen at 6 months for personal and work-related burnout, respectively. The mean score for patient-related burnout at 12 months was 25.57, and this number had increased significantly by 5.8 points (CI 3.2,8.5; Pburnout was 55.9%. Conclusion: Our study showed that burnout is a common problem among interns. The high incidence of burnout demonstrates the need for appropriate strategies to prevent adverse effects on doctors' quality of life and on the quality of care patients receive. PMID:27046399

  15. Validation of Maturity Offset in the Fels Longitudinal Study.

    Malina, Robert M; Choh, Audrey C; Czerwinski, Stefan A; Chumlea, Wm Cameron

    2016-08-01

    Sex-specific equations for predicting maturity offset, time before or after peak height velocity (PHV), were evaluated in 63 girls and 74 boys from the Fels Longitudinal Study. Serially measured heights (0.1 cm), sitting heights (0.1 cm), weights (0.1 kg), and estimated leg lengths (0.1 cm) from 8 to 18 years were used. Predicted age at PHV (years) was calculated as the difference between chronological age (CA) and maturity offset. Actual age at PHV for each child was derived with a triple logistic model (Bock-Thissen-du Toit). Mean predicted maturity offset was negative and lowest at 8 years and increased linearly with increasing CA. Predicted ages at PHV increased linearly with CA from 8 to 18 years in girls and from 8 to 13 years in boys; predictions varied within relatively narrow limits from 12 to 15 years and then increased to 18 years in boys. Differences between predicted and actual ages at PHV among youth of contrasting maturity status were significant across the age range in both sexes. Dependence of predicted age at PHV upon CA at prediction and on actual age at PHV limits its utility as an indicator of maturity timing and in sport talent programs. PMID:26757350

  16. Parent-offspring similarity for drinking: a longitudinal adoption study.

    McGue, Matt; Malone, Steve; Keyes, Margaret; Iacono, William G

    2014-11-01

    Parent-offspring resemblance for drinking was investigated in a sample of 409 adopted and 208 non-adopted families participating in the Sibling Interaction and Behavior Study. Drinking data was available for 1,229 offspring, assessed longitudinally up to three times in the age range from 10 to 28 years. A single drinking index was computed from four items measuring quantity, frequency and density of drinking. As expected, the mean drinking index increased with age, was greater in males as compared to females (although not at the younger ages), but did not vary significantly by adoption status. Parent-offspring correlation in drinking did not vary significantly by either offspring or parent gender but did differ significantly by adoption status. In adopted families, the parent-offspring correlation was statistically significant at all ages but decreased for the oldest age group (age 22-28). In non-adopted families, the parent-offspring correlation was statistically significant at all ages and increased in the oldest age group. Findings imply that genetic influences on drinking behavior increase with age while shared family environment influences decline, especially during the transition from late-adolescence to early adulthood. PMID:25224596

  17. Rationales, design and recruitment for the Elfe longitudinal study

    Salines Georges

    2009-09-01

    Full Text Available Abstract Background Many factors act simultaneously in childhood to influence health status, life chances and well being, including pre-birth influences, the environmental pollutants of early life, health status but also the social influences of family and school. A cohort study is needed to disentangle these influences and explore attribution. Methods Elfe will be a nationally representative cohort of 20 000 children followed from birth to adulthood using a multidisciplinary approach. The cohort will be based on the INSEE Permanent Demographic Panel (EDP established using census data and civil records. The sample size has been defined in order to match the representativeness criteria and to obtain some prevalence estimation, but also to address the research area of low exposure/rare effects. The cohort will be based on repeated surveys by face to face or phone interview (at birth and each year as well as medical interview (at 2 years and examination (at 6 years. Furthermore, biological samples will be taken at birth to evaluate the foetal exposition to toxic substances, environmental sensors will be placed in the child's homes. Pilot studies have been initiated in 2007 (500 children with an overall acceptance rate of 55% and are currently under progress, the 2-year survey being carried out in October this year. Discussion The longitudinal study will provide a unique source of data to analyse the development of children in their environment, to study the various factors interacting throughout the life course up to adulthood and to determine the impact of childhood experience on the individual's physical, psychological, social and professional development.

  18. A 5-Year Investigation of Children's Adaptive Functioning Following Conformal Radiation Therapy for Localized Ependymoma

    Purpose: Conformal and intensity modulated radiation therapies have the potential to preserve cognitive outcomes in children with ependymoma; however, functional behavior remains uninvestigated. This longitudinal investigation prospectively examined intelligence quotient (IQ) and adaptive functioning during the first 5 years after irradiation in children diagnosed with ependymoma. Methods and Materials: The study cohort consisted of 123 children with intracranial ependymoma. Mean age at irradiation was 4.60 years (95% confidence interval [CI], 3.85-5.35). Serial neurocognitive evaluations, including an age-appropriate IQ measure and the Vineland Adaptive Behavior Scales (VABS), were completed before irradiation, 6 months after treatment, and annually for 5 years. A total of 579 neurocognitive evaluations were included in these analyses. Results: Baseline IQ and VABS were below normative means (P<.05), although within the average range. Linear mixed models revealed stable IQ and VABS across the follow-up period, except for the VABS Communication Index, which declined significantly (P=.015). Annual change in IQ (−.04 points) did not correlate with annual change in VABS (−.90 to +.44 points). Clinical factors associated with poorer baseline performance (P<.05) included preirradiation chemotherapy, cerebrospinal fluid shunt placement, number and extent of surgical resections, and younger age at treatment. No clinical factors significantly affected the rate of change in scores. Conclusions: Conformal and intensity modulated radiation therapies provided relative sparing of functional outcomes including IQ and adaptive behaviors, even in very young children. Communication skills remained vulnerable and should be the target of preventive and rehabilitative interventions.

  19. Longitudinal variability of time-location/activity patterns of population at different ages: a longitudinal study in California

    Cassady Diana L

    2011-09-01

    Full Text Available Abstract Background Longitudinal time-activity data are important for exposure modeling, since the extent to which short-term time-activity data represent long-term activity patterns is not well understood. This study was designed to evaluate longitudinal variations in human time-activity patterns. Method We report on 24-hour recall diaries and questionnaires collected via the internet from 151 parents of young children (mostly under age 55, and from 55 older adults of ages 55 and older, for both a weekday and a weekend day every three months over an 18-month period. Parents also provided data for their children. The self-administrated diary and questionnaire distinguished ~30 frequently visited microenvironments and ~20 activities which we selected to represent opportunities for exposure to toxic environmental compounds. Due to the non-normal distribution of time-location/activity data, we employed generalized linear mixed-distribution mixed-effect models to examine intra- and inter-individual variations. Here we describe variation in the likelihood of and time spent engaging in an activity or being in a microenvironment by age group, day-type (weekday/weekend, season (warm/cool, sex, employment status, and over the follow-up period. Results As expected, day-type and season influence time spent in many location and activity categories. Longitudinal changes were also observed, e.g., young children slept less with increasing follow-up, transit time increased, and time spent on working and shopping decreased during the study, possibly related to human physiological changes with age and changes in macro-economic factors such as gas prices and the economic recession. Conclusions This study provides valuable new information about time-activity assessed longitudinally in three major age groups and greatly expands our knowledge about intra- and inter-individual variations in time-location/activity patterns. Longitudinal variations beyond weekly and

  20. Nine year longitudinal retrospective study of Taekwondo injuries.

    Kazemi, Mohsen; Chudolinski, Artur; Turgeon, Matt; Simon, Aaron; Ho, Eric; Coombe, Lianne

    2009-12-01

    This retrospective longitudinal study aims to describe reported Taekwondo injuries and to examine associations between competitor experience level, age and gender, and the type, location, and mechanism of injury sustained. Additionally, we examined whether recent rule changes concerning increased point value of head shots in adult Taekwondo competition had affected injury incidence.This study was a summation of 9 years of data of competition injury reports, which included 904 injury reports spanning 58 individual competitions. The data was collected on standardized injury reports at time of injury during competition. Care was provided to the athletes, but the type of care provided was not included in the study. Participants included athletes injured during competition who sought care by the health care team, and for whom an injury report was filled out. The data analysis was performed at the Canadian Memorial Chiropractic College.The three most common locations of presenting injury were the head (19%), foot (16%), and thigh (9%). The most common mechanism of presenting injury was found to be a defensive kick (44%), followed by an offensive kick (35%). The most commonly diagnosed injuries were contusions (36%), sprains (19%), and strains (15%). Coloured belts had a higher incidence of contusions, while black belts sustained more joint irritation injuries. Black belts were more likely to suffer multiple injuries. Colored belts suffered more injuries while receiving a kick, while black belts had a larger influence of past history of injury. We found no significant difference in location or type of injury when comparing pre versus post rule change. The most common locations of injury are head, foot, and thigh respectively, and are areas for concern when considering preventative measures. Colour belt competitors are more likely to sustain contusions, which the authors believe is due to more aggressive tactics and lack of control. Those more likely to be injured tend to

  1. Pelvic pain after childbirth: a longitudinal population study.

    Bjelland, Elisabeth Krefting; Owe, Katrine Mari; Pingel, Ronnie; Kristiansson, Per; Vangen, Siri; Eberhard-Gran, Malin

    2016-03-01

    In this longitudinal population study, the aims were to study associations of mode of delivery with new onset of pelvic pain and changes in pelvic pain scores up to 7 to 18 months after childbirth. We included 20,248 participants enrolled in the Norwegian Mother and Child Cohort Study (1999-2008) without preexisting pelvic pain in pregnancy. Data were obtained by 4 self-administered questionnaires and linked to the Medical Birth Registry of Norway. A total of 4.5% of the women reported new onset of pelvic pain 0 to 3 months postpartum. Compared to unassisted vaginal delivery, operative vaginal delivery was associated with increased odds of pelvic pain (adjusted odds ratio [OR]: 1.30; 95% confidence interval [CI]: 1.06-1.59). Planned and emergency cesarean deliveries were associated with reduced odds of pelvic pain (adjusted OR: 0.48; 95% CI: 0.31-0.74 and adjusted OR: 0.65; 95% CI: 0.49-0.87, respectively). Planned cesarean delivery, young maternal age, and low Symptom Checklist-8 scores were associated with low pelvic pain scores after childbirth. A history of pain was the only factor associated with increased pelvic pain scores over time (P = 0.047). We conclude that new onset of pelvic pain after childbirth was not commonly reported, particularly following cesarean delivery. Overall, pelvic pain scores were rather low at all time points and women with a history of pain reported increased pelvic pain scores over time. Hence, clinicians should follow up women with pelvic pain after a difficult childbirth experience, particularly if they have a history of pain. PMID:26588694

  2. Undergraduates’ opinion after 5-year experience with rotary endodontic instruments

    Flávia Sens Fagundes Tomazinho; Gisele Aihara Haragushiku; Flares Baratto Filho; Denise Piotto Leonardi; Maria da Graça Kfouri Lopes; Alexandre Moro

    2011-01-01

    Introduction: Dentistry evolution in the past few years has revolutionized daily practice in some specialties. One of these revolutions has occurred in Endodontics due to the advancement of rotary techniques for root canal preparation and its subsequent incorporation into the teaching of Dentistry undergraduates. Objective: The aim of this study was to report a 5-year experience on the undergraduate laboratorial and clinical use of rotary endodontic preparation at a private university. Materi...

  3. Functional Status After Injury: A Longitudinal Study of Geriatric Trauma

    Kelley-Quon, Lorraine; Min, Lillian; Morley, Eric; Hiatt, Jonathan R; Cryer, Henry; Tillou, Areti

    2010-01-01

    We evaluated self-rated functional status measured longitudinally in the year following injury in a geriatric trauma population. The Longitudinal (L) group included 37 of 60 eligible trauma patients age ≥ 65 years admitted December 2006-November 2007 for > 24 hours who completed a Short Functional Status questionnaire (SFS) at 3, 6, and 12 months after injury. The SFS yields scores of 0-5 (5=independent in all five activities of daily living, ADLs) and has been validated among community-dwell...

  4. Does time heal all wounds? A longitudinal study of the development of posttraumatic stress symptoms in parents of survivors of childhood cancer and bereaved parents

    Ljungman, Lisa; Hovén, Emma; Ljungman, Gustaf; Cernvall, Martin; von Essen, Louise

    2015-01-01

    Background: A lack of longitudinal studies has hampered the understanding of the development of posttraumatic stress symptoms (PTSS) in parents of children diagnosed with cancer. This study examines level of PTSS and prevalence of posttraumatic stress disorder (PTSD) from shortly after diagnosis up to 5 years after end of treatment or child’s death, in mothers and fathers. Methods: A design with seven assessments (T1–T7) was used. T1–T3 were administered during treatment and T4–T7 after end o...

  5. A Longitudinal Study of Midage Women with Indicators of Disordered Eating

    Fairweather-Schmidt, A. Kate; Lee, Christina; Wade, Tracey D.

    2015-01-01

    This longitudinal study of midage women has two main aims: to examine the effect of disordered eating (DE) on quality of life (QoL) among women, including a comparison with a younger cohort and to investigate the mediating roles of both depressive symptoms and social support on the longitudinal relationship between DE and QoL as potential…

  6. A longitudinal study on the stability over time of school and teacher effects on student outcomes

    Kyriakides, Leonidas; Creemers, Bert P. M.

    2008-01-01

    This paper reviews educational effectiveness theory, concentrating on the time stability of the teacher and school effect. The contribution of longitudinal studies investigating the long-term effect of schools and teachers to modelling educational effectiveness is discussed. Findings of a longitudin

  7. Use of Missing Data Methods in Longitudinal Studies: The Persistence of Bad Practices in Developmental Psychology

    Jelicic, Helena; Phelps, Erin; Lerner, Richard M.

    2009-01-01

    Developmental science rests on describing, explaining, and optimizing intraindividual changes and, hence, empirically requires longitudinal research. Problems of missing data arise in most longitudinal studies, thus creating challenges for interpreting the substance and structure of intraindividual change. Using a sample of reports of longitudinal…

  8. High School Social Climate and Antisocial Behavior: A 10 Year Longitudinal and Multilevel Study

    Leblanc, Line; Swisher, Raymond; Vitaro, Frank; Tremblay, Richard E.

    2008-01-01

    A longitudinal and multilevel approach is used to examine the relationship between antisocial behavior during adolescence and high school social climate. The data are taken from a longitudinal study of 1,233 boys and girls who attended 217 public and private high schools. Students' disruptive behaviors were assessed yearly from 6 to 12 years of…

  9. What Alumni Value from New Product Development Education: A Longitudinal Study

    Cobb, Corie L.; Hey, Jonathan; Agogino, Alice M.; Beckman, Sara L.; Kim, Sohyeong

    2016-01-01

    We present a longitudinal study of what graduates take away from a cross-disciplinary graduate-level New Product Development (NPD) course at UC Berkeley over a 15-year period from 1996-2010. We designed and deployed a longitudinal survey and interviewed a segment of our NPD alumni population to better understand how well our course prepared these…

  10. Problematics of Time and Timing in the Longitudinal Study of Human Development: Theoretical and Methodological Issues

    Lerner, Richard M.; Schwartz, Seth J.; Phelps, Erin

    2009-01-01

    Studying human development involves describing, explaining, and optimizing intraindividual change and interindividual differences in such change and, as such, requires longitudinal research. The selection of the appropriate type of longitudinal design requires selecting the option that best addresses the theoretical questions asked about…

  11. Predictors of English fluency among Hmong refugees in Minnesota: a longitudinal study.

    Westermeyer, J; Her, C

    1996-01-01

    The objective of this study was to assess factors associated with later acquisition of English language fluency among Hmong refugees in Minnesota. Fluency in a society's lingua franca is a critical skill in psychosocial adaptation and mental health. A longitudinal study design was used, in which premigration and early postmigration factors were related to subsequent English fluency. The first group of 102 Hmong refugees located in Minnesota by the Immigration and Naturalization Service participated, and were interviewed in their homes. Hmong research assistants collected data using a questionnaire format at 1.5 years following resettlement in the U.S. Eight years later, two measures of English language competence were obtained: a self-assessment and an objective measure of English language fluency. Self-assessed fluency and performance on a brief English test showed good correlation. Greater English fluency on both measures was predicted by the following: younger age, male gender, education or vocational training in Laos prior to migration, occupation in Laos requiring literacy, study of English while in Asia, less proximity to other Hmong households in the U.S., any educational involvement in the U.S. (except English as a second language or ESL training), and not receiving welfare. Self-assessment of English fluency appeared to be a valid measure of competence in English. Demographic characteristics, certain premigration experiences, and early postmigration experiences predicted English fluency after 10 years in the U.S. ESL training was not associated with eventual English fluency on either self-assessment or objective testing. Recommendations are made to enhance English fluency, and hence the psychosocial adaptation of refuguees and other immigrants to the U.S. PMID:9225568

  12. Kinaesthetic acuity in adolescent boys : A longitudinal study

    Visser, J.; Geuze, R.H.

    2000-01-01

    The Kinaesthetic Sensitivity Test (KST) was used to measure the development of kinaesthetic acuity in adolescent boys. Thirty boys were tested longitudinally, at intervals of 6 months, between the ages of 11 1/2 and 14 years. A second group of 20 boys was tested at the ages of 14 and 16 1/2 years. T

  13. Prediction of the development of reading comprehension: a longitudinal study

    Verhoeven, L.T.W.; Leeuwe, J.F.J. van

    2008-01-01

    Specific effects of word decoding, vocabulary and listening comprehension abilities on the development of reading comprehension were longitudinally examined for a representative sample of 2143 Dutch children throughout the elementary school period. An attempt was made to test two theoretical framewo

  14. A Chinese Longitudinal Study on Work/Family Enrichment

    Lu, Luo

    2011-01-01

    Purpose: The purpose of this paper is to explore reciprocal relationships between work/family resources, work/family enrichment (WFE), and work/family satisfaction in a Chinese society. Design/methodology/approach: A longitudinal design was adopted using a three-wave panel sample. Data were obtained from 310 Taiwanese employees on three occasions,…

  15. Social-psychological adjustment to multiple sclerosis. A longitudinal study.

    Brooks, N A; Matson, R R

    1982-01-01

    This study employs a longitudinal design to analyze the adjustment process of 103 people diagnosed with multiple sclerosis and in the middle and later stages of their illness careers. The mean age of the sample at Time 2 is 52 years, and mean duration since diagnosis is 17 years. A highly reliable self concept measure is the indicator of adjustment and changes in adjustment from T1 (1974) to T2 (1981). Four sets of variables are analyzed in their relationship to adjustment: (1) socio-demographic; (2) disease-related; (3) medical; and (4) social-psychological. Females are more likely than males to show positive adjustment (improving self concepts). Hours of employment and living arrangement are also related to the adjustment process. The vast majority of respondents show only slight decline in mobility, but among the disease related variables, number of episodes (exacerbations) in past seven years is the strongest predictor of changes in adjustment. Nearly half the respondents seek medical attention for their M.S. once a year or less, and the choice of health care professional is related to changes in the course of the disease. Subjects with an internal locus of control have more positive adjustment scores. Those who say they cope through acceptance of the disease show improvements in self concept while those reporting religion or family as major coping strategies have decreasing self concepts. Results indicate that the majority make satisfactory adjustment as indicated by maintenance of positive self concepts over the 7 year period, although the disease is chronic and progressive. For patients in the middle and later stages of illness careers, the data suggest comprehensive rehabilitation efforts that enhance autonomy and develop the social-psychological resources of the lifestyle. PMID:7157043

  16. Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women.

    Compston, Juliet E; Wyman, Allison; FitzGerald, Gordon; Adachi, Jonathan D; Chapurlat, Roland D; Cooper, Cyrus; Díez-Pérez, Adolfo; Gehlbach, Stephen H; Greenspan, Susan L; Hooven, Frederick H; LaCroix, Andrea Z; March, Lyn; Netelenbos, J Coen; Nieves, Jeri W; Pfeilschifter, Johannes; Rossini, Maurizio; Roux, Christian; Saag, Kenneth G; Siris, Ethel S; Silverman, Stuart; Watts, Nelson B; Anderson, Frederick A

    2016-07-01

    Increased fracture risk has been associated with weight loss in postmenopausal women, but the time course over which this occurs has not been established. The aim of this study was to examine the effects of unintentional weight loss of ≥10 lb (4.5 kg) in postmenopausal women on fracture risk at multiple sites up to 5 years after weight loss. Using data from the Global Longitudinal Study of Osteoporosis in Women (GLOW), we analyzed the relationships between self-reported unintentional weight loss of ≥10 lb at baseline, year 2, or year 3 and incident clinical fracture in the years after weight loss. Complete data were available in 40,179 women (mean age ± SD 68 ± 8.3 years). Five-year cumulative fracture rate was estimated using the Kaplan-Meier method, and adjusted hazard ratios for weight loss as a time-varying covariate were calculated from Cox multiple regression models. Unintentional weight loss at baseline was associated with a significantly increased risk of fracture of the clavicle, wrist, spine, rib, hip, and pelvis for up to 5 years after weight loss. Adjusted hazard ratios showed a significant association between unintentional weight loss and fracture of the hip, spine, and clavicle within 1 year of weight loss, and these associations were still present at 5 years. These findings demonstrate increased fracture risk at several sites after unintentional weight loss in postmenopausal women. This increase is found as early as 1 year after weight loss, emphasizing the need for prompt fracture risk assessment and appropriate management to reduce fracture risk in this population. © 2016 American Society for Bone and Mineral Research. PMID:26861139

  17. Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women†

    Compston, Juliet E.; Wyman, A; FitzGerald, Gordon; Adachi, Jonathan D.; Chapurlat, Roland D.; Cooper, Cyrus; Díez-Pérez, Adolfo; Gehlbach, Stephen H; Greenspan, Susan L.; Hooven, Frederick H.; LaCroix, Andrea Z.; March, Lyn; Coen Netelenbos, J.; Nieves, Jeri W.; Pfeilschifter, Johannes; Rossini, Maurizio; Roux, Christian; Saag, Kenneth G.; Siris, Ethel S.; Silverman, Stuart; Watts, Nelson B.; Anderson, Frederick A.

    2016-01-01

    Increased fracture risk has been associated with weight loss in postmenopausal women but the time course over which this occurs has not been established. The aim of this study was to examine the effects of unintentional weight loss of ≥10 lb (4.5 kg) in postmenopausal women on fracture risk at multiple sites up to 5 years following weight loss. Using data from the Global Longitudinal Study of Osteoporosis in Women (GLOW) we analyzed the relationships between self-reported unintentional weight loss of ≥10 lb at baseline, year 2, or year 3 and incident clinical fracture in the years following weight loss. Complete data were available in 40,179 women (mean age ± SD 68 ± 8.3 years). Five-year cumulative fracture rate was estimated using the Kaplan-Meier method, and adjusted hazard ratios for weight loss as a time-varying covariate were calculated from Cox multiple regression models. Unintentional weight loss at baseline was associated with a significantly increased risk of fracture of the clavicle, wrist, spine, rib, hip, and pelvis for up to 5 years following weight loss. Adjusted hazard ratios showed a significant association between unintentional weight loss and fracture of the hip, spine, and clavicle within 1 year of weight loss, and these associations were still present at 5 years. These findings demonstrate increased fracture risk at several sites after unintentional weight loss in postmenopausal women. This increase is seen as early as 1 year following weight loss, emphasizing the need for prompt fracture risk assessment and appropriate management to reduce fracture risk in this population. PMID:26861139

  18. Diffusion of a collaborative care model in primary care: a longitudinal qualitative study

    Vedel Isabelle

    2013-01-01

    Full Text Available Background Although collaborative team models (CTM improve care processes and health outcomes, their diffusion poses challenges related to difficulties in securing their adoption by primary care clinicians (PCPs. The objectives of this study are to understand: (1 how the perceived characteristics of a CTM influenced clinicians' decision to adopt -or not- the model; and (2 the model's diffusion process. Methods We conducted a longitudinal case study based on the Diffusion of Innovations Theory. First, diffusion curves were developed for all 175 PCPs and 59 nurses practicing in one borough of Paris. Second, semi-structured interviews were conducted with a representative sample of 40 PCPs and 15 nurses to better understand the implementation dynamics. Results Diffusion curves showed that 3.5 years after the start of the implementation, 100% of nurses and over 80% of PCPs had adopted the CTM. The dynamics of the CTM's diffusion were different between the PCPs and the nurses. The slopes of the two curves are also distinctly different. Among the nurses, the critical mass of adopters was attained faster, since they adopted the CTM earlier and more quickly than the PCPs. Results of the semi-structured interviews showed that these differences in diffusion dynamics were mostly founded in differences between the PCPs' and the nurses' perceptions of the CTM's compatibility with norms, values and practices and its relative advantage (impact on patient management and work practices. Opinion leaders played a key role in the diffusion of the CTM among PCPs. Conclusion CTM diffusion is a social phenomenon that requires a major commitment by clinicians and a willingness to take risks; the role of opinion leaders is key. Paying attention to the notion of a critical mass of adopters is essential to developing implementation strategies that will accelerate the adoption process by clinicians.

  19. Maximising retention in a longitudinal study of genital Chlamydia trachomatis among young women in Australia

    Birden Hudson; Gurrin Lyle C; Kaldor John; Pirotta Marie; Currie Marian; McNamee Kathleen; Tabrizi Sepehr N; Donovan Basil; Walker Sandra M; Bradshaw Catriona; Chen Marcus Y; Urban Eve; Fairley Christopher K; Walker Jennifer; Harindra Veerakathy

    2011-01-01

    Abstract Background Cohort studies are an important study design however they are difficult to implement, often suffer from poor retention, low participation and bias. The aims of this paper are to describe the methods used to recruit and retain young women in a longitudinal study and to explore factors associated with loss to follow up. Methods The Chlamydia Incidence and Re-infection Rates Study (CIRIS) was a longitudinal study of Australian women aged 16 to 25 years recruited from primary ...

  20. Recruiting and Retaining Mobile Young Injection Drug Users in a Longitudinal Study

    Lankenau, Stephen E.; Sanders, Bill; Hathazi, Dodi; Jackson Bloom, Jennifer

    2011-01-01

    Longitudinal studies that research homeless persons or transient drug users face particular challenges in retaining subjects. Between 2005 and 2006, 101 mobile young injection drug users were recruited in Los Angeles into a 2-year longitudinal study. Several features of ethnographic methodology, including fieldwork and qualitative interviews, and modifications to the original design, such as toll-free calls routed directly to ethnographer cell phones and wiring incentive payments, resulted in retention of 78% of subjects for the first follow-up interview. Longitudinal studies that are flexible and based upon qualitative methodologies are more likely to retain mobile subjects while also uncovering emergent research findings. PMID:20222779

  1. Pattern of Rheumatic Fever in Egyptian Children Younger Than 5 Years

    Ibrahim, L. A.; Fattouh, A. M.; Hamza, H. S.; Attia, W. A.

    2013-01-01

    Aims: Acute rheumatic fever (ARF) is common between 5-15 years, uncommon with different presentation 25 in children below 5 years. The aim of this study is to assess the frequency and characterize the pattern of 26 presentation of rheumatic fever (RF) in Egyptian children younger than 5 years. Study Design: Retrospective study. Place and Duration of the Study: Pediatric department, cardiology division, Cairo University Children’s Hospital, 5 years follow up. Methodology: We retrospectiv...

  2. Adiposity, obesity, and arterial aging: longitudinal study of aortic stiffness in the Whitehall II cohort.

    Brunner, Eric J; Shipley, Martin J; Ahmadi-Abhari, Sara; Tabak, Adam G; McEniery, Carmel M; Wilkinson, Ian B; Marmot, Michael G; Singh-Manoux, Archana; Kivimaki, Mika

    2015-08-01

    We sought to determine whether adiposity in later midlife is an independent predictor of accelerated stiffening of the aorta. Whitehall II study participants (3789 men; 1383 women) underwent carotid-femoral applanation tonometry at the mean age of 66 and again 4 years later. General adiposity by body mass index, central adiposity by waist circumference and waist:hip ratio, and fat mass percent by body impedance were assessed 5 years before and at baseline. In linear mixed models adjusted for age, sex, ethnicity, and mean arterial pressure, all adiposity measures were associated with aortic stiffening measured as increase in pulse wave velocity (PWV) between baseline and follow-up. The associations were similar in the metabolically healthy and unhealthy, according to Adult Treatment Panel-III criteria excluding waist circumference. C-reactive protein and interleukin-6 levels accounted for part of the longitudinal association between adiposity and PWV change. Adjusting for chronic disease, antihypertensive medication and risk factors, standardized effects of general and central adiposity and fat mass percent on PWV increase (m/s) were similar (0.14, 95% confidence interval: 0.05-0.24, P=0.003; 0.17, 0.08-0.27, P<0.001; 0.14, 0.05-0.22, P=0.002, respectively). Previous adiposity was associated with aortic stiffening independent of change in adiposity, glycaemia, and lipid levels across PWV assessments. We estimated that the body mass index-linked PWV increase will account for 12% of the projected increase in cardiovascular risk because of high body mass index. General and central adiposity in later midlife were strong independent predictors of aortic stiffening. Our findings suggest that adiposity is an important and potentially modifiable determinant of arterial aging. PMID:26056335

  3. How do 5 year olds understand questions?

    Sauerland, Uli; Grohmann, Kleanthes; Teresa Guasti, Maria; Andjelkovic, Darinka; Argus, Reili; Armon-Lotem, Sharon; Arosio, Farizio; Arvam, Larisa; Costa, João; Dabašinskienė, Ineta; De Lopez, Kristine M. Jensen; Gatt, Daniela; Grech, Helen; Haman, Ewa; Hout, Angeliek van; Hrzica, Gordana; Kainhofer, Judith; Kamandulyte-Merfeldiené, Laura; Kunnari, Sari; Kovačević, Melita; Kuvac Kraljevic, Jelena; Lipowska,, Katarzyna; Mejias, Sandrine; Popović, Maša; Ruzaitè, Juratè; Savić, Maja; Sevcenco, Anca; Varlokosta, Spyridoula; Varnava, Marina; Yatsushiro, Kazuko

    2016-01-01

    The comprehension of constituent questions is an important topic for language acquisition research and for applications in the diagnosis of language impairment. We present the the results of a study investigating the comprehension of different types of questions by five year old, typically...... developing children across 19 European countries, 18 different languages, and 7 language (sub-)families. We studied the effects of two factors on question formation: a) whether the question contains a simple interrogative word like ‘who’ or a complex one like ‘which princess’, and b) whether the question...... facilitate children’s understanding of questions: having overt case morphology, having a single lexical item for both ‘who’ and ‘which’, and the use of synthetic verbal forms. [156 words]...

  4. Progression along the Bipolar Spectrum: A Longitudinal Study of Predictors of Conversion from Bipolar Spectrum Conditions to Bipolar I and II Disorders

    Alloy, Lauren B.; Urošević, Snežana; Abramson, Lyn Y.; Jager-Hyman, Shari; Nusslock, Robin; Whitehouse, Wayne G.; Hogan, Michael

    2011-01-01

    Little longitudinal research has examined progression to more severe bipolar disorders in individuals with “soft” bipolar spectrum conditions. We examine rates and predictors of progression to bipolar I and II diagnoses in a non-patient sample of college-age participants (n = 201) with high General Behavior Inventory scores and childhood or adolescent onset of “soft” bipolar spectrum disorders followed longitudinally for 4.5 years from the Longitudinal Investigation of Bipolar Spectrum (LIBS)...

  5. A longitudinal study of food intake patterns and obesity in adult Danish men and women

    Togo, P; Osler, M; Sørensen, T I A;

    2004-01-01

    OBJECTIVE: The aim of this study was to test the hypothesis that specific food intake patterns or changes in food intake patterns were related to future changes in body mass index (BMI). DESIGN: Longitudinal observational study, with clinical and questionnaire examinations at baseline and two...... factor scores, changes in factor scores and subsequent BMI changes or obesity were found. CONCLUSION: In this longitudinal study of a Danish population, food intake factors could not consistently predict changes in BMI or obesity development....

  6. Education Does Not Slow Cognitive Decline with Aging: 12-Year Evidence from the Victoria Longitudinal Study

    Zahodne, L.B.; Glymour, M.M.; Sparks, C.; Bontempo, D.; Dixon, R A; MacDonald, S.W.S.; Manly, J J

    2011-01-01

    Although the relationship between education and cognitive status is well-known, evidence regarding whether education moderates the trajectory of cognitive change in late life is conflicting. Early studies suggested that higher levels of education attenuate cognitive decline. More recent studies using improved longitudinal methods have not found that education moderates decline. Few studies have explored whether education exerts different effects on longitudinal changes within different cognit...

  7. Immediate loading of four freestanding implants retaining a mandibular overdenture: 3-5 years follow-up study%下颌即刻负荷种植覆盖义齿3~5年临床观察

    张晓; 俞红; 张峰

    2012-01-01

    目的 探讨种植体支持的覆盖义齿即刻负荷后种植体的长期稳定性.方法 对北京大学口腔医学院·口腔医院第一门诊部就诊的10例牙列缺失患者采用Ankylos SynCone种植系统支持的即刻负荷覆盖义齿修复,均为下颌全颌覆盖义齿.10例均在下颌颏孔之间植入4枚种植体,共植入40枚,修复后平均随访3~5年,以共振频率分析和影像学检查评价种植体稳定性和边缘骨丢失情况.结果 所有种植体无松动脱落,均获得良好的骨结合,存留率为100%;种植体稳定性指数值均> 65,与临床检查种植体稳定性良好一致.种植体周软组织健康,未见X线连续透射影,边缘骨吸收<1 mm.结论 下颌即刻负荷种植覆盖义齿修复3~5年随访临床效果满意.%Objective To evaluate the clinical results of immediate loading of four freestanding implants retaining a mandibular overdenture.Methods Ten patients were treated with implants retaining a mandibular overdenture.All 40 implants had osseointegmtion.The treatment method was based on immediate loading of four interforaminal implants without the use of a bar retainer.The denture was placed on and retained by prefabricated conical crowns that were inserted into the existing denture base by direct intraoral polymerization immediately after surgery and supported by the corresponding conical primary implant abutments.Clinical examination and radiographs were conducted.Changes in the marginal bone level around the implants were evaluated with radiograph.The mean follow-up time was 60 months(range 24-60 months).Results The cumulative implant survival rate was 100%.All implants presented healthy peri-implant soft tissue conditions showing low value of clinical parameters.Average marginal bone level change after 5 years of function was (0.52 ± 0.49) mm.The patients were satisfied with the outcomes.Conclusions The preliminary clinical results of this clinical study suggest that immediate

  8. Baseline ambulatory knee kinematics are associated with changes in cartilage thickness in osteoarthritic patients over 5 years.

    Favre, Julien; Erhart-Hledik, Jennifer C; Chehab, Eric F; Andriacchi, Thomas P

    2016-06-14

    Although kinematic alterations during walking have been reported with knee osteoarthritis (OA), there is a paucity of longitudinal data, therefore limiting our understanding of the role of kinematics in OA development. This study tested the hypothesis that less knee extension angle and less posterior displacement of the femur relative to the tibia during the heel-strike portion of the gait cycle are associated with greater loss of medial cartilage thickness during a follow-up period of five years. This study also tested for associations between flexion-extension angle and anterior-posterior displacement during other periods of the gait cycle and 5-year cartilage thinning. 16 subjects with moderate medial knee OA were tested with gait analysis and MRI at baseline and had a follow-up MRI after 5 years. Linear regressions were used to assess the relationship between changes in cartilage thickness and baseline kinematics using Pearson correlation coefficients. Multivariate regressions were also performed to adjust for gender, baseline age, BMI, walking speed, Kellgren/Lawrence grade, and baseline knee pain score. As hypothesized, baseline knee flexion angle and femoral displacement during heel-strike and other gait cycle periods were significantly associated with medial femoral and tibial cartilage thinning at the 5 year follow-up; these associations were strengthened after adjustment for covariates. This study provided new insight into the pathogenesis of knee OA where baseline knee kinematics were associated with longitudinal disease progression. These results could serve as a basis for developing newer gait modification interventions to reduce the risk for developing knee OA. PMID:27178021

  9. The Alcohol Warning and Adolescents: 5-Year Effects.

    MacKinnon, David P.; Nohre, Liva; Pentz, Mary Ann; Stacy, Alan W.

    2000-01-01

    Examined the effect of alcohol warning labels on adolescents during the first 5 years that the warning was required. Surveys of 10th and 12th grade students over 5 years indicated that the initial positive effects of the labels on adolescents leveled off after 3.5 years. The labels have not affected adolescents' beliefs about alcohol or…

  10. The Longitudinal Case Study: From Schon's Model to Self-Directed Learning.

    Borduas, Francine; Gagnon, Robert; Laprise, Rejean; Lacoursiere, Yves

    2001-01-01

    An interactive workshop based on longitudinal case studies and using Schon's reflection-in-action and reflection-on-action was presented to 37 physicians. Pre/postworkshop data from eight participants showed significant improvements in their knowledge. (SK)

  11. A Longitudinal Study of Objectively Measured Built Environment as Determinant of Physical Activity in Young Adults

    Schipperijn, Jasper; Ried-Larsen, Mathias; Nielsen, Merete S;

    2015-01-01

    BACKGROUND: This longitudinal study aimed to examine if a Moveability Index (MI), based on objectively measured built environment characteristics, was a determinant for objectively measured physical activity (PA) among young adults. METHOD: Data collected from 177 persons participating in the...

  12. A Longitudinal Multilevel Study of Individual Characteristics and Classroom Norms in Explaining Bullying Behaviors

    Sentse, Miranda; Veenstra, Rene; Kiuru, Noona; Salmivalli, Christina

    2015-01-01

    This three-wave longitudinal study was set out to examine the interplay between individual characteristics (social standing in the classroom) and descriptive and injunctive classroom norms (behavior and attitudes, respectively) in explaining subsequent bullying behavior, defined as initiating, assis

  13. Trajectories of Mental Health over 16 Years amongst Young Adult Women: The Australian Longitudinal Study on Women's Health

    Holden, Libby; Ware, Robert S.; Lee, Christina

    2016-01-01

    This article used data from 5,171 young women participating in the Australian Longitudinal Study on Women's Health, a nationally representative longitudinal cohort study, to identify longitudinal trajectory patterns of mental health across 6 surveys over 16 years of early adulthood, from age 18-23 to age 34-39. In addition, we identified both…

  14. The heritability of insomnia from childhood to adolescence: results from a longitudinal twin study

    Barclay, Nicola L; Gehrman, P R; Gregory, Alice M.; Eaves, L. J.; Silberg, J. L.

    2014-01-01

    Study Objectives: To determine prevalence and heritability of insomnia during middle/late childhood and adolescence; examine longitudinal associations in insomnia over time; and assess the extent to which genetic and environmental factors on insomnia remain stable, or whether new factors come into play, across this developmental period. Design: Longitudinal twin study. Setting: Academic medical center. Patients or Participants: There were 739 complete monozygotic twin pairs (52%) ...

  15. Visual Impairment, Hearing Loss and Cognitive Function in an Older Population: Longitudinal Findings from the Blue Mountains Eye Study.

    Hong, Thomas; Mitchell, Paul; Burlutsky, George; Liew, Gerald; Wang, Jie Jin

    2016-01-01

    The presence of visual impairment (VI) and hearing loss (HL) with may be a marker for subsequent cognitive decline over time in older people. A prospective, longitudinal population-based study of the 3654 participants of the Blue Mountains Eye Study were assessed for the associations between VI and HL and a decline in mini-mental state examination (MMSE) scores over a duration of 10 years from the 5-year (baseline of this report) to the 15-year follow-up visits. MMSE was assessed at the 5-, 10- and 15-year follow-up visits. A decline ≥3 scores from 5-year to 10- or 15-year visits indicated possible cognitive decline. VI was defined as best-corrected visual acuity 40 decibels in the worse-ear and dual sensory impairment (DSI) was defined by the co-presence of VI and HL, detected at 5-year follow-up (baseline of this report). Participants with no VI and HL over the same 5- or 10-year corresponding period were controls. Associations of VI, HL and DSI with possible cognitive decline were assessed using logistic regression models adjusting for age and sex after excluding subjects with a stroke history. The presence of VI, HL or DSI was not associated with possible cognitive decline over 5 years (odds ratio (OR) 0.84, 95% confidence-intervals (CI) 0.40-1.79, OR 1.02, 95% CI 0.61-1.70 and 1.41, 95% CI 0.54-3.72, respectively) or 10 years (OR 1.09, 95% CI 0.52-2.30, OR 1.09, 95% CI 0.65-1.82 and 1.15, 95% CI 0.28-4.73, respectively). There were no changes to these findings after adjustment for other potential confounders. Age was significantly associated with possible cognitive decline (OR 1.07, 95% CI 1.04-1.10 for both periods). Neither visual impairment, hearing loss nor dual sensory impairment was independently associated with subsequent decline in cognition. PMID:26808979

  16. Visual Impairment, Hearing Loss and Cognitive Function in an Older Population: Longitudinal Findings from the Blue Mountains Eye Study.

    Thomas Hong

    Full Text Available The presence of visual impairment (VI and hearing loss (HL with may be a marker for subsequent cognitive decline over time in older people. A prospective, longitudinal population-based study of the 3654 participants of the Blue Mountains Eye Study were assessed for the associations between VI and HL and a decline in mini-mental state examination (MMSE scores over a duration of 10 years from the 5-year (baseline of this report to the 15-year follow-up visits. MMSE was assessed at the 5-, 10- and 15-year follow-up visits. A decline ≥3 scores from 5-year to 10- or 15-year visits indicated possible cognitive decline. VI was defined as best-corrected visual acuity 40 decibels in the worse-ear and dual sensory impairment (DSI was defined by the co-presence of VI and HL, detected at 5-year follow-up (baseline of this report. Participants with no VI and HL over the same 5- or 10-year corresponding period were controls. Associations of VI, HL and DSI with possible cognitive decline were assessed using logistic regression models adjusting for age and sex after excluding subjects with a stroke history. The presence of VI, HL or DSI was not associated with possible cognitive decline over 5 years (odds ratio (OR 0.84, 95% confidence-intervals (CI 0.40-1.79, OR 1.02, 95% CI 0.61-1.70 and 1.41, 95% CI 0.54-3.72, respectively or 10 years (OR 1.09, 95% CI 0.52-2.30, OR 1.09, 95% CI 0.65-1.82 and 1.15, 95% CI 0.28-4.73, respectively. There were no changes to these findings after adjustment for other potential confounders. Age was significantly associated with possible cognitive decline (OR 1.07, 95% CI 1.04-1.10 for both periods. Neither visual impairment, hearing loss nor dual sensory impairment was independently associated with subsequent decline in cognition.

  17. Non-communicable disease risk factor patterns among mining industry workers in Papua, Indonesia: longitudinal findings from the Cardiovascular Outcomes in a Papuan Population and Estimation of Risk (COPPER) Study

    Rodriguez-Fernandez, Rodrigo; Rahajeng, Ekowati; Viliani, Francesca; Kushadiwijaya, Haripurnomo; Rachel M Amiya; Bangs, Michael J

    2015-01-01

    Objectives Non-communicable diseases (NCDs) constitute an increasing slice of the global burden of disease, with the South-East Asia region projected to see the highest increase in NCD-related deaths over the next decade. Mining industry employees may be exposed to various factors potentially elevating their NCD risk. This study aimed to assess the distribution and 5-year longitudinal trends of key metabolic NCD risk factors in a cohort of copper–gold mining company workers in Papua, Indonesi...

  18. Environmental Quality Analysis and Countermeasure Study in Jianyang Municipality during the 11 th 5 -- Year Period%“十一五”期间建阳市环境质量状况分析与对策探讨

    张金秀

    2012-01-01

    Based on the environmental quality monitoring data of Jianyang Municipality during the 11 th 5 - Year Period (2006 -2010), an analysis is done on the environmental quality in Jianyang during the same period. After the analysis of the environmental quality of the surface water, air and noise, the countermeasures and suggestions are put forward.%根据“十一五”(2006—2010年)期间建阳市的环境质量监测数据,对“十一五”期间建阳市环境质量状况进行了分析。对地表水、环境空气、环境噪声的质量进行了分析,提出改善环境质量的对策与措施。

  19. Longitudinal Trajectories in Guilford-Zimmerman Temperament Survey Data: Results from the Baltimore Longitudinal Study of Aging

    Terracciano, Antonio; McCrae, Robert R.; Costa, Paul T.

    2009-01-01

    Developmental trends in personality traits over 42 years were examined using data from the Baltimore Longitudinal Study on Aging (N = 2,359, aged 17 to 98), collected from 1958 to 2002. Hierarchical Linear Modeling analyses revealed cumulative mean-level changes averaging about 0.5 SD across adulthood. Scales related to Extraversion showed distinct developmental patterns: General Activity declined from age 60 to 90; Restraint increased; Ascendance peaked around age 60; and Sociability declined slightly. Scales related to Neuroticism showed curvilinear declines up to age 70 and then increased. Scales related to Agreeableness and Openness changed little; Masculinity declined linearly. Significant individual variability in change was found. Although intercepts differed, trajectories were similar for men and women. Attrition and death had no effect on slopes. This study highlights the use of lower-order traits in providing a more nuanced picture of developmental change. PMID:16497954

  20. Development of the perceptual span in reading: A longitudinal study.

    Sperlich, Anja; Meixner, Johannes; Laubrock, Jochen

    2016-06-01

    The perceptual span is a standard measure of parafoveal processing, which is considered highly important for efficient reading. Is the perceptual span a stable indicator of reading performance? What drives its development? Do initially slower and faster readers converge or diverge over development? Here we present the first longitudinal data on the development of the perceptual span in elementary school children. Using the moving window technique, eye movements of 127 German children in three age groups (Grades 1, 2, and 3 in Year 1) were recorded at two time points (T1 and T2) 1year apart. Introducing a new measure of the perceptual span, nonlinear mixed-effects modeling was used to separate window size effects from asymptotic reading performance. Cross-sectional differences were well replicated longitudinally. Asymptotic reading rate increased monotonously with grade, but in a decelerating fashion. A significant change in the perceptual span was observed only between Grades 2 and 3. Together with results from a cross-lagged panel model, this suggests that the perceptual span increases as a consequence of relatively well-established word reading. Stabilities of observed and predicted reading rates were high after Grade 1, whereas the perceptual span was only moderately stable for all grades. Comparing faster and slower readers as assessed at T1, in general, a pattern of stable between-group differences emerged rather than a compensatory pattern; second and third graders even showed a Matthew effect in reading rate and the perceptual span, respectively. PMID:26950508

  1. Secondary Science Teachers' Beliefs and Persistence: A Longitudinal Mixed-Methods Study

    Wong, Sissy S.; Luft, Julie A.

    2015-01-01

    While many studies focus on why teachers leave the classroom, there remains a need to study why teachers persist in teaching. One area to study is the beliefs of teachers, which may impact persistence in the field. This 5-year mixed-methods study explored whether 35 beginning secondary science teachers' beliefs were related to their persistence in…

  2. Loss and gain cycles? A longitudinal study about burnout, engagement and self-efficacy

    Susana Llorens-Gumbau; Marisa Salanova-Soria

    2014-01-01

    The present longitudinal study (two waves), conducted on a population of 274 secondary-school teachers, expands on previous research on burnout and work engagement. Accordingly, the effect of organizational factors (obstacles, facilitators) as well as personal resources (self-efficacy) on burnout and engagement is tested longitudinally following the Social Cognitive Theory. More specifically, we test the loss and gain cycles, and reciprocal relationships concerning burnout, engagement, and se...

  3. Body Dissatisfaction from Adolescence to Young Adulthood: Findings from a 10-Year Longitudinal Study

    Bucchianeri, Michaela M.; Arikian, Aimee J.; Hannan, Peter J.; Eisenberg, Marla E.; Neumark-Sztainer, Dianne

    2012-01-01

    Given mixed findings regarding the unique trajectories of female and male adolescents’ body dissatisfaction over time, comprehensive longitudinal examinations are needed. This 10-year longitudinal, population-based study, with 1,902 participants from diverse ethnic/racial and socioeconomic backgrounds in the Minneapolis/St. Paul metropolitan area, examined changes in body dissatisfaction from adolescence to young adulthood. Results revealed that: (a) female and male participants’ body dissati...

  4. Television viewing time and risk of incident diabetes mellitus: the English Longitudinal Study of Ageing.

    Smith, L; M. Hamer

    2014-01-01

    Aim To investigate the longitudinal association between television viewing time and risk of incident diabetes mellitus in an elderly sample of adults in England. Methods Analyses of data from the English Longitudinal Study of Ageing. At baseline (2008), participants reported their television viewing time and physical activity level. Diabetes mellitus was recorded from self-reported physician diagnosis at 2-year follow-up. Associations between television viewing time and combined television vi...

  5. Motivation mediates the perfectionism–burnout relationship: A three-wave longitudinal study with junior athletes

    Madigan, Daniel J.; Stoeber, Joachim; Passfield, Louis

    2016-01-01

    Perfectionism in sports has been shown to predict longitudinal changes in athlete burnout. What mediates these changes over time, however, is still unclear. Adopting a self-determination theory perspective and using a three-wave longitudinal design, the present study examined perfectionistic strivings, perfectionistic concerns, autonomous motivation, controlled motivation, and athlete burnout in 141 junior athletes (mean age 17.3 years) over 6 months of active training. When multilevel struct...

  6. Protocol of the PSYCHOTSH study: association between neonatal thyroid stimulating hormone concentration and intellectual, psychomotor and psychosocial development at 4–5 year of age: a retrospective cohort study

    Trumpff, Caroline; Vanderfaeillie, Johan; Vercruysse, Nathalie; De Schepper, Jean; Tafforeau, Jean; Van Oyen, Herman; Vandevijvere, Stefanie

    2014-01-01

    Background Several European countries, including Belgium, still suffer from mild iodine deficiency. Thyroid stimulating hormone (TSH) concentration in whole blood measured at birth has been proposed as an indicator of maternal iodine status during the last trimester of pregnancy. It has been shown that mild iodine deficiency during pregnancy may affect the neurodevelopment of the offspring. In several studies, elevated TSH levels at birth were associated with suboptimal cognitive and psychomo...

  7. A Longitudinal Study on Human Outdoor Decomposition in Central Texas.

    Suckling, Joanna K; Spradley, M Katherine; Godde, Kanya

    2016-01-01

    The development of a methodology that estimates the postmortem interval (PMI) from stages of decomposition is a goal for which forensic practitioners strive. A proposed equation (Megyesi et al. 2005) that utilizes total body score (TBS) and accumulated degree days (ADD) was tested using longitudinal data collected from human remains donated to the Forensic Anthropology Research Facility (FARF) at Texas State University-San Marcos. Exact binomial tests examined the rate of the equation to successfully predict ADD. Statistically significant differences were found between ADD estimated by the equation and the observed value for decomposition stage. Differences remained significant after carnivore scavenged donations were removed from analysis. Low success rates for the equation to predict ADD from TBS and the wide standard errors demonstrate the need to re-evaluate the use of this equation and methodology for PMI estimation in different environments; rather, multivariate methods and equations should be derived that are environmentally specific. PMID:26258913

  8. Parenting practices and school dropout: a longitudinal study.

    Blondal, Kristjana S; Adalbjarnardottir, Sigrun

    2009-01-01

    Adolescents' perceptions of parenting style and parental involvement in their education were examined longitudinally and related to school dropout among Icelandic youth (N = 427). Results indicated that adolescents who, at age 14, characterized their parents as authoritative (showing acceptance and supervision) were more likely to have completed upper secondary school by age 22 than adolescents from non-authoritative families, controlling for adolescents' gender, socioeconomic status (SES), temperament, and parental involvement. Parenting style seems to more strongly predict school dropout than parental involvement. Further, parenting style may moderate the relationship between parental involvement and dropout, but not in all groups; only in authoritative families does parental involvement decrease the likelihood of school dropout. Furthermore, even after controlling for previous academic achievement, adolescents from authoritative families were less likely to drop out than adolescents from authoritarian and neglectful families. These findings emphasize the importance of encouraging quality parent-child relationships in order to reduce the likelihood of school dropout. PMID:20432598

  9. What is the utility of using syndromic surveillance systems during large subnational infectious gastrointestinal disease outbreaks? An observational study using case studies from the past 5 years in England.

    Todkill, D; Elliot, A J; Morbey, R; Harris, J; Hawker, J; Edeghere, O; Smith, G E

    2016-08-01

    Syndromic surveillance systems in England have demonstrated utility in the early identification of seasonal gastrointestinal illness (GI) tracking its spatio-temporal distribution and enabling early public health action. There would be additional public health utility if syndromic surveillance systems could detect or track subnational infectious disease outbreaks. To investigate using syndromic surveillance for this purpose we retrospectively identified eight large GI outbreaks between 2009 and 2014 (four randomly and four purposively sampled). We then examined syndromic surveillance information prospectively collected by the Real-time Syndromic Surveillance team within Public Health England for evidence of possible outbreak-related changes. None of the outbreaks were identified contemporaneously and no alerts were made to relevant public health teams. Retrospectively, two of the outbreaks - which happened at similar times and in proximal geographical locations - demonstrated changes in the local trends of relevant syndromic indicators and exhibited a clustering of statistical alarms, but did not warrant alerting local health protection teams. Our suite of syndromic surveillance systems may be more suited to their original purposes than as means of detecting or monitoring localized, subnational GI outbreaks. This should, however, be considered in the context of this study's limitations; further prospective work is needed to fully explore the use of syndromic surveillance for this purpose. Provided geographical coverage is sufficient, syndromic surveillance systems could be able to provide reassurance of no or minor excess healthcare systems usage during localized GI incidents. PMID:27033409

  10. Hypomineralized second primary molars: Prevalence data in Dutch 5-year-olds

    Elfrink, M.E.C.; Schuller, A.A.; Weerheijm, K.L.; Veerkamp, J.S.J.

    2008-01-01

    The aim of this cross-sectional observational study was to report on the prevalence of hypomineralizations in second primary molars in 5-year-old Dutch children. In the study 386 (45% girls) 5-year-old Dutch children, all insured by a Health Insurance Fund, participated. Scoring criteria for molar i

  11. What is Learned from Longitudinal Studies of Advertising and Youth Drinking and Smoking? A Critical Assessment

    Jon P. Nelson

    2010-03-01

    Full Text Available This paper assesses the methodology employed in longitudinal studies of advertising and youth drinking and smoking behaviors. These studies often are given a causal interpretation in the psychology and public health literatures. Four issues are examined from the perspective of econometrics. First, specification and validation of empirical models. Second, empirical issues associated with measures of advertising receptivity and exposure. Third, potential endogeneity of receptivity and exposure variables. Fourth, sample selection bias in baseline and follow-up surveys. Longitudinal studies reviewed include 20 studies of youth drinking and 26 studies of youth smoking. Substantial shortcomings are found in the studies, which preclude a causal interpretation.

  12. Relação do índice de massa corporal, da relação cintura-quadril e da circunferência abdominal com a mortalidade em mulheres idosas: seguimento de 5 anos Relationship between body mass index, waist circumference, and waist-to-hip ratio and mortality in elderly women: a 5-year follow-up study

    Marcos A. S. Cabrera

    2005-06-01

    Full Text Available Este estudo analisa a associação entre a relação cintura-quadril (RCQ, a circunferência abdominal (CA e o índice de massa corporal (IMC com a mortalidade total e cardiovascular em 575 mulheres idosas ambulatoriais por um seguimento de cinco anos. Os maiores quartis de RCQ, CA e IMC, bem como as categorias pré-determinadas de IMC, foram analisados como variáveis preditivas e analisada a interferência de algumas variáveis confundidoras. Oitenta e oito mulheres morreram durante o seguimento (15,4%. As mulheres com baixo peso (IMC 0,97 estava associado com a maior mortalidade total, entretanto, na análise multivariada o aumento de RCQ apresentou uma associação independente com a mortalidade total, apenas entre as mulheres de 60 a 80 anos. Nenhuma medida antropométrica apresentou uma associação significativa com a mortalidade cardiovascular. Os resultados identificaram o baixo peso e a RCQ como preditores de mortalidade total em idosas, principalmente entre as mulheres com até 80 anos.This study examines the association between body mass index (BMI, waist-to-hip ratio (WHR, and waist circumference (WC and all-cause and cardiovascular mortality in elderly women in a 5-year longitudinal study of 575 female outpatients 60 years and over. The highest BMI, WHR, and WC quartiles and predefined BMI categories were analyzed as predictive variables. Death occurred in 88 (15.4%. Underweight (BMI 0.97 was associated with all-cause mortality. However, after adjustment for age, smoking, and previous cardiovascular diseases, the increase in WHR was positively associated only in women from 60 to 80 years of age. None of the anthropometric measurements was associated with cardiovascular mortality. The results indicate that underweight and increased waist-to-hip ratio were predictors of all-cause mortality in elderly women, mainly among those under 80 years.

  13. A longitudinal study of the reciprocal effects of alcohol use and interpersonal violence among Australian young people.

    Scholes-Balog, Kirsty E; Hemphill, Sheryl A; Kremer, Peter; Toumbourou, John W

    2013-12-01

    The impact of alcohol-related violence on individuals and society continues to receive attention from both media and policy makers. However, the longitudinal relationship between alcohol consumption and violence is unclear, with findings from prospective studies producing mixed results. The current study utilized Australian data from the International Youth Development Study to examine longitudinal relationships between alcohol consumption and severe interpersonal violence across the developmental periods of early adolescence to late adolescence/emerging adulthood. The full sample comprised 849 adolescents (53.8 % female) who had been followed up over a 5 year period, from Grade 7 secondary school (age 13) until Grade 11 secondary school (age 17). Cross-lagged path analysis was used to examine reciprocal relationships between alcohol consumption and interpersonal violence; analyses controlled for a range of covariates considered to be common risk factors for both behaviors. Alcohol use during early and mid adolescence was found to predict violence 2 years later, whereas a bi-directional relationship between adolescent heavy episodic drinking and violence was observed. Some of these relationships were not significant when covariates such as family conflict and affiliation with antisocial and drug using friends were included in the models. These findings suggest that risk processes begin in late childhood or very early adolescence; efforts to reduce one problem behavior are likely to reduce the other. Further, the role that social and family contexts have in influencing the relationships between alcohol use and interpersonal violence should be considered in future research to better inform preventive efforts. PMID:23354419

  14. Changes in physical activity over time in young children: a longitudinal study using accelerometers.

    Rachael W Taylor

    Full Text Available Previous research has suggested that marked declines in physical activity occur during the preschool years, and across the transition into school. However, longitudinal studies using objective measures of activity have been limited by sample size and length of follow-up. The aims of this study were to determine how overall activity and time in different intensities of activity change in children followed from 3 to 7 years. Children (n = 242 wore Actical accelerometers at 3, 4, 5, 5.5, 6.5 and 7 years of age during all waking and sleeping hours for a minimum of 5 days. Time in sedentary (S, light (L, moderate (M, and vigorous (V physical activity was determined using available cut points. Data were analyzed using a mixed model and expressed as counts per minute (cpm, overall activity and the ratio of active time to sedentary time (LMV:S, adjusted for multiple confounders including sex, age, time worn, and weather. At 5 years, physical activity had declined substantially to around half that observed at 3 years. Although starting school was associated with a further short-term (6-month decline in activity (cpm in both boys (difference; 95% CI: -98; -149, -46 and girls (-124; -174, -74, both P<0.001, this proved to be relatively transient; activity levels were similar at 6-7 years as they were just prior to starting school. Boys were more physically active than girls as indicated by an overall 12% (95% CI: 2, 22% higher ratio of active to sedentary time (P = 0.014, but the pattern of this difference did not change from 3 to 7 years. Time worn and weather variables were significant predictors of activity. In conclusion, both boys and girls show a marked decline in activity from 3 to 4 years of age, a decrease that is essentially maintained through to 7 years of age. Factors driving this marked decrease need to be determined to enable the development of targeted interventions.

  15. Cross-sectional study on oral health behaviors among children aged 5-year old in Mianyang City,Sichuan%四川省绵阳市5岁儿童口腔健康现况调查

    申洋; 刘凡; 蒋莹; 曾庆奇; 常春; 王燕玲

    2015-01-01

    目的:了解绵阳市5岁儿童口腔健康现状,为进一步开展口腔健康教育提供参考依据。方法采用多阶段抽样的方法,抽取绵阳市3所幼儿园285名5岁儿童家长,参照《全国第三次口腔健康流行病学调查方案》中5岁儿童家长问卷对儿童家长进行调查。结果家长对于“窝沟封闭能预防儿童龋齿”的知晓率为11.6%,口腔知识主要来源是电视/广播(64.9%)和报纸/杂志(55.4%);90.2%的家长认同“保护孩子六龄牙很重要”;每天进食含糖食品的儿童为69.0%,75.8%儿童曾有睡前吃甜食行为;3岁以前开始刷牙的儿童占73.0%,每天帮助孩子刷牙和检查刷牙效果的家长占18.6%和19.6%;75.8%的儿童过去1年未进行任何口腔检查,其中46.7%的家长认为儿童牙齿没问题,不需要检查;最近一次口腔就诊的主要原因是急、慢性牙痛,定期检查牙齿的仅占4.2%;知识得分与态度得分之间存在正相关(r =0.285),同行为得分之间存在正相关(r =0.213)。结论绵阳市5岁儿童口腔健康行为有待改善,虽然多数儿童家长有较好的口腔健康态度和一定的口腔健康知识,但是转化为实际行动的能力较弱,仍需有针对性的开展健康促进活动,以使儿童形成正确的口腔卫生行为。%Objective To understand the oral health behaviors status among children aged 5-year old in Mianyang city,and provide evidence for further implementing oral health education.Methods Using multistage sampling,285 par-ents of children aged 5-year old were selected in Mianyang city according to 3rd Chinese national oral health investigation cri-teria and children’s oral health behaviors were investigated by questionnaire.Results The awareness rate of parents’for‘Dental sealant could prevent caries for children’ was 11.6%,the main sources of oral knowledge were TV /radio (64.9%),newspaper

  16. Gender representation in the vision sciences: A longitudinal study.

    Cooper, Emily A; Radonjic, Ana

    2016-01-01

    Understanding the current status and historical trends of gender representation within a research field is an important component of fostering a diverse and inclusive scientific community. Here, we report on the gender representation of a large sample of the vision science research community--the attendees of the Annual Meeting of the Vision Sciences Society (VSS). Our analysis shows that the majority of scientists at all career levels in our sample are male. This imbalance is most pronounced for the senior scientists, whereas predoctoral students are nearly balanced between the genders. Historically, the gender imbalance was larger than it is at present, and it has followed a slow-but-steady trend toward gender parity over the past decade. A longitudinal analysis based on tracking individual attendees shows a larger dropout rate for female than male predoctoral trainees. However, among the trainees who continue in the vision science field after graduate school, evidence suggests that career advancement is quite similar between the genders. In an additional analysis, we found that the VSS Young Investigator awardees and the abstract review committee members reflect substantial gender imbalances, suggesting that these recognitions have yet to catch up with the greater gender balance of the rising generation of junior vision scientists. We hope that this report will encourage awareness of issues of diversity in the scientific community and further promote the development of a research field in which all talented scientists are supported to succeed. PMID:26818970

  17. Forbidden fruit? A longitudinal study of Christianity, sex, and marriage.

    Pedersen, Willy

    2014-01-01

    Does religion still play a role in explorations of romance and sexuality among adolescents and young adults in a secular society such as Norway? Does it influence the type of living arrangements chosen? A population-based sample (n = 2,454) was followed longitudinally from their midteens to their late 20s using survey and register data. Christian involvement in teenage years was associated with subsequent less "precoital" exploration, less masturbation, delayed sexual intercourse, and a smaller number of sex partners. However, there were no associations with prevalence of same-sex experiences. Christians also postponed initiating romantic relationships and chose marriage over cohabitation. Associations were reduced after controlling for confounding factors but remained significant. Some associations (for example, the form of residential union chosen) were present only in the most "active" Christians. In other areas, such as "precoital explorations" and the age at which intercourse is initiated, Christian norms seem to play a role in much broader segments of the population. The findings indicate that Christianity may continue to influence young Norwegians' experiences of sexuality and cohabitation more than has been expected. PMID:23631689

  18. Perianal injuries resulting from sexual abuse: a longitudinal study.

    McCann, J; Voris, J

    1993-02-01

    Four children who incurred perianal injuries as a result of a sexual assault were followed on a longitudinal basis to document the anatomical changes that ensued. The subjects, whose ages ranged from 4 to 8 years, were followed from 1 week to 14 months. They were examined in both supine and prone knee-chest positions and a 35-mm camera mounted on a colposcope was used to record their injuries. At the time of the initial examination, there were a variety of findings including erythema of the tissues, edema of the skin folds, localized venous engorgement, dilation of the external anal sphincter, and lacerations of different depths. Superficial lacerations reepithelized within 1 to 11 days. The second-degree wounds in two of the children were healed by the 1- and 5-week return visits, leaving narrow bands of scar tissue. In the two subjects who were followed the longest, signs of both a second-degree laceration and a surgically repaired third-degree injury had virtually disappeared by 12 to 14 months after the assaults. The wounds in one subject, infected with a herpes simplex type 2 virus, remained erythematous for a longer period of time than did similar injuries in the other children. A skin tag created by the avulsion of the tissues in one subject persisted, although it became less obvious as it retracted into the redundant folds of the perianal tissues over time. PMID:8424016

  19. Clinical management and burden of bipolar disorder: a multinational longitudinal study (WAVE-bd Study)

    Moreno-Manzanaro Miriam; Langosch Jens M; Figueira Maria; Blasco-Colmenares Elena; Vieta Eduard; Medina Esteban

    2011-01-01

    Abstract Background Studies in bipolar disorder (BD) to date are limited in their ability to provide a whole-disease perspective - their scope has generally been confined to a single disease phase and/or a specific treatment. Moreover, most clinical trials have focused on the manic phase of disease, and not on depression, which is associated with the greatest disease burden. There are few longitudinal studies covering both types of patients with BD (I and II) and the whole course of the disea...

  20. A MIXTURE DROPOUT MECHANISM IN A LONGITUDINAL STUDY WITH TWO TIME POINTS: A METHADONE STUDY

    Zohreh Toghrayee

    2014-01-01

    Full Text Available One of the most important issues that confront statisticians in longitudinal studies is dropouts. A variety of reasons may lead to withdrawal from a study and produce two different missingness mechanisms, namely, missing at random and non-ignorable dropouts. Nevertheless, none of these mechanisms is tenable in most studies. In addition, it may be that not all of dropouts are nonignorable. Many dropout handling methods have been employed by assuming only one of these dropout mechanisms. In this study, the dropout indicator is improved to take into account both dropout mechanisms. In this two-stage approach, a selection model is combined with an imputation method for dropout process in a longitudinal study with two time points. Simulation studies in a variety of situations are conducted to evaluate this approach in estimating the mean of the response variable at the second time point. This parameter is estimated by using maximum likelihood method. The results of the simulation studies indicate the superiority of the proposed method to the existing ones in estimating the mean of the variable with dropouts. In addition, this method is performed on a methadone dataset of 161 patients admitted to an Iranian clinic to estimate the final methadone dose.

  1. In the long run...longitudinal studies of psychopathology in children. Committee on Child Psychology. Group for the Advancement of Psychiatry. Report no.143.

    1999-01-01

    in infancy correlate poorly with temperamental characteristics measured at age 4 or 5 years, they appear to be much more stable and correlate well with temperament at ages 8 and 12 years. Some of these temperamental characteristics, particularly aggressivity and negativity at age 5 years, are serious risk factors for behavioral psychopathology at age 8 or 12 years and, possibly, at later ages as well. Aggressive, negative 5-year-olds do not necessarily grow out of their problems. Their problems are important and should be dealt with when children are age 5 years. What does appear important is early language development. Delays in language development or developmental language disorders are risk factors for later psychopathology. Fifty percent of school-age children with language problems requiring speech and language therapy also have diagnosable psychopathology. Hyperactivity and short attention span are characteristics that tend to persist in later childhood--even adulthood. Alone, each of these characteristics may not be a risk factor for later psychopathology, but, when accompanied by oppositional behavior and conduct disorder, the outcome is detrimental to the child. Many studies have shown that children with these comorbid problems are at risk later for becoming delinquent and antisocial. Conduct disorder in childhood, which is much more common in males, is a risk factor for later delinquency, even if it is not associated with hyperactivity. Again, early intervention is important. The effects of comorbidity in this instance can be serious. Comorbidity in general, especially as children grow older, leads to adverse social, academic, and psychopathological outcomes. Depression does occur in children, in all of its adult manifestations. Mania, in contrast, is rarely seen in children younger than age 12 years. Depression in school-age children can be severe or mild. In contrast to adolescents with depression, depressed children are most likely to have somatic

  2. Higher maternal protectiveness is associated with higher odds of child overweight and obesity: a longitudinal Australian study.

    Hancock, Kirsten J; Lawrence, David; Zubrick, Stephen R

    2014-01-01

    In recent years there has been an increasing interest in overprotective parenting and the potential role it plays in child development. While some have argued that a trend towards increased parental fear and reduced opportunity for independent mobility may be linked to increasing rates of child overweight and obesity, there is limited empirical information available to support this claim. Using data from the Longitudinal Study of Australian Children, this study aimed to examine the longitudinal relationships between maternal protectiveness and child overweight and obesity. A cohort of 4-5 year old children was followed up at 6-7, 8-9 and 10-11 years of age (n  =  2596). Measures included a protective parenting scale administered when children were 6-7 and 8-9 years of age, child body mass index (BMI), family characteristics including household income, neighbourhood disadvantage, child's position amongst siblings, and maternal BMI, education, employment, mental health and age at first birth. International Obesity Taskforce age- and sex-specific BMI cut points were used to determine if children were in the normal, overweight or obese BMI range. There was no association between maternal protectiveness and the odds of children being overweight or obese at age 4-5, 6-7 or 8-9 years. However at age 10-11 years, a 1 standard deviation increase in maternal protectiveness was associated with a 13% increase in the odds of children being overweight or obese. The results provide evidence of a relationship between maternal protectiveness and child overweight and obesity, however further research is required to understand the mechanism(s) that links the two concepts. PMID:24955586

  3. [Neurotoxicity of chemical substances in the workplace. VI. Longitudinal study of persons occupationally exposed to mercury].

    Triebig, G; Grobe, T; Saure, E; Schaller, K H; Weltle, D; Valentin, H

    1984-01-01

    A longitudinal study was performed on eleven persons, who had been chronically exposed to mercury (Hg) (3 to 31 years, median 5 years) in 1977, 1980 resp., and 1982. During their work in a chemical plant they had had contact to elemental Hg and various inorganic as well as organic mercury compounds. The main purpose of the investigation was the evaluation of possible adverse effects to the nervous system caused by mercury. The internal Hg-exposure was measured by mercury analysis in blood (Hg-B) and in urine (Hg-U). Furthermore "time-weighted average" levels were calculated on the basis of former Hg-determinations from 1974 to 1982. For Hg-B these values ranged between 26 and 104 microgram/dl (median 42 microgram/l) and for Hg-U between 73 and 434 microgram/g creatinine (median 233 microgram/g creatinine) (upper normal levels: Hg-B: 5 microgram/l; Hg-U: 5 microgram/g creatinine). The determination of the peripheral nerve conduction velocities (NLG) of motor and sensory fibers as well as the registration of somatosensory-evoked potentials (SEP) revealed no pathological results, except one borderline case. The NLG- and SEP-values did not significantly differ from those of non exposed persons or from those of former NLG-determinations. No correlations were found between indicators of Hg-exposure and neurophysiological parameters regarding dose-effect-relationship. Statistical differences resulted in the time-dependent test of the psychological test battery performed in comparison to age-matched control persons of equal socio-economous status. In additional, significant relationships were calculated between Hg-exposure and these tests. Considering the inter- and intraindividual variations of the psychological test results, there were no substantial alterations in the total findings over the observed period except for one case. Workers with Hg-exposure below the current BAT-values (Hg-B 50 microgram/l, Hg-U 200 microgram/l) showed no pathological findings in the

  4. Comparative Study on Community Natural Recovery of Kmeria septentrionalis Dandy (Magnoliaceae) after 5 Years%5年自然恢复前后单性木兰群落的比较研究

    覃文更; 覃国乐; 冯昌林; 黄承标; 唐小平

    2012-01-01

    应用固定监测样方法对5年自然恢复前后的单性木兰群落进行了系统全面的调查,分析了单性木兰群落的物种组成、物种多样性和群落结构的变化.结果表明,(1)组成群落的植物科、属、种数量均有所减少,但物种个体数量却明显增加;(2)乔木、灌木层物种多样性变幅较大,草本层则波动不大,群落还处于初期演替阶段,各物种间竞争强烈,一些下层阳性物种正在消失,中性、耐阴性物种在不断补充,群落物种多样性变得更加复杂;(3)濒危植物单性木兰的密度、盖度和重要值明显增加,单性木兰对自然环境有较强的适应性,在群落中的优势地位不断加强,群落正向着以单性木兰为主要建群种的方向发展.%We used a fixed monitoring sample method to conduct a systematic and comprehensive investigation to community natural recovery of Kmeria septentrionalis , analyse community species composition,species diversity and community structure in the process of 5-year succession for the plants K. Septentrionalis. The results showed that:(l)The number of families,genera and species in the community decreased significantly, but individuals in a certain species were increased obviously. (2) Species diversities of trees and shrubs changed significantly, while herb layer fluctuation is not obvious. The community succession is still in an early restoration stage. The interspecies competition was strong. Some light demanding tree species in substrate are disappearing, yet neutral shade and tolerant species are keeping on adding, and community species diversities are become more complicated. (3)The species density,cover and important value of endangered K. Septentrionalis increased dramatically. K. Septentrionalis have strong adaptability to the natural environment,and the status of dominance in the community has been continuously strengthened. Thecommunity is developing in the direction of K. Septentrionalis to be

  5. Development of body composition and its relationship with physical activity in healthy Swedish children : A longitudinal study until 4.5 years of age including evaluation of methods to assess physical activity and energy intake

    Henriksson, Hanna

    2015-01-01

    Childhood obesity according to the World Health Organization is one of the most serious public health challenges of the 21st century. The proportion of childhood obesity is high both globally and in Sweden. This is of great concern since obese children tend to stay obese in adulthood. In order to develop strategies to prevent early childhood obesity more knowledge is needed regarding factors explaining why children become overweight and obese. Preventive strategies require accurate and easy-t...

  6. Early Number and Arithmetic Performance of Ecuadorian 4-5-Year-Olds

    Bojorque, Gina; Torbeyns, Joke; Moscoso, Jheni; Van Nijlen, Daniël; Verschaffel, Lieven

    2015-01-01

    This study aimed at (a) constructing a reliable and valid test to assess Ecuadorian 4-5-year olds' number and arithmetic skills; (b) providing empirical data on Ecuadorian 4-5-year olds' number and arithmetic skills; and (c) confronting these children's actual performances with the performances expected by national experts in this domain. We…

  7. 75 FR 66724 - Endangered and Threatened Species; 5-Year Review

    2010-10-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE... (NOAA), Commerce. ACTION: Notice of availability of a 5-year review for the U.S. Distinct Population... electronic message to Shelley.norton@noaa.gov . Electronic copies of the 5-year review are available...

  8. Auditory sensory deficits in developmental dyslexia: a longitudinal ERP study.

    Stefanics, Gabor; Fosker, Tim; Huss, Martina; Mead, Natasha; Szucs, Denes; Goswami, Usha

    2011-08-01

    The core difficulty in developmental dyslexia across languages is a "phonological deficit", a specific difficulty with the neural representation of the sound structure of words. Recent data across languages suggest that this phonological deficit arises in part from inefficient auditory processing of the rate of change of the amplitude envelope at syllable onset (inefficient sensory processing of rise time). Rise time is a complex percept that also involves changes in duration and perceived intensity. Understanding the neural mechanisms that give rise to the phonological deficit in dyslexia is important for optimising educational interventions. In a three-deviant passive 'oddball' paradigm and a corresponding blocked 'deviant-alone' control condition we recorded ERPs to tones varying in rise time, duration and intensity in children with dyslexia and typically developing children longitudinally. We report here results from test Phases 1 and 2, when participants were aged 8-10 years. We found an MMN to duration, but not to rise time nor intensity deviants, at both time points for both groups. For rise time, duration and intensity we found group effects in both the Oddball and Blocked conditions. There was a slower fronto-central P1 response in the dyslexic group compared to controls. The amplitude of the P1 fronto-centrally to tones with slower rise times and lower intensity was smaller compared to tones with sharper rise times and higher intensity in the Oddball condition, for children with dyslexia only. The latency of this ERP component for all three stimuli was shorter on the right compared to the left hemisphere, only for the dyslexic group in the Blocked condition. Furthermore, we found decreased N1c amplitude to tones with slower rise times compared to tones with sharper rise times for children with dyslexia, only in the Oddball condition. Several other effects of stimulus type, age and laterality were also observed. Our data suggest that neuronal responses

  9. 阳泉市0至5岁儿童生长发育与营养状况研究%Study of growth and nutritional status of children aged 0-5 years in Yangquan city

    潘玉泉; 罗莎莎; 李红宇; 宋智华; 李忠义; 段淑红; 葛建军; 李虹; 潘建平; 张华

    2011-01-01

    Objective To investigate the status of growth and nutrition of children aged 0-5 years in Yangquan so as to provide basis for analyzing influencing factors and taking intervention measures. Methods With stratified cluster sampling method, 6334 children of 0-5 years old from 5 counties were divided into 19 age groups of boys and girls respectively. Their body weight, length/height, chest circumference, head circumference and upper arm circumference were measured, their hemoglobin were determined and rickets were evaluated. Results Generally speaking, physical growth of children under age 5 conformed to general laws. Compared with the measured values of normal children under age 7 in 9 suburbs in China in 2005, children' s average height and weight of each age groups were higher. Among children under age 5, the incidence of malnutrition was 2. 26% ( 1. 14% in city, 3. 63% in countryside ), low birth weight was 1.47% , stunting was 2. 23% and emaciation was 2. 49%. The detection rate of obesity was 2. 03% ( 2. 57% in city, 1. 58% in countryside ), which was lower than that of children in China city. The prevalence of rickets in children under age 3 was 30. 89% , which was consistent with the national prevalence. The prevalence rate of anemia was 4. 94% ( 3. 61% in city, 5. 81% in countryside ), which was lower than that in other areas. Conclusion At present, the growth and development of children under age 5 in Yangquan are in line with general laws. The level of growth and development has a tendency of gradual increasing. The nutritional status of children is generally good, but that of rural children is poorer than urban children. The prevalence of rickets for children under age 3 in Yangquan is almost consistent with national level, but the prevalence of anemia is lower than other areas.%目的 了解阳泉市0至5岁儿童生长发育及营养状况,为进一步分析影响因素及制定相应的干预措施提供依据.方法 采用分层整群

  10. Theory of mind in children with 'lesser variants' of autism : a longitudinal study

    Serra, M; Loth, FL; van Geert, PLC; Hurkens, E; Minderaa, RB

    2002-01-01

    Background: The study investigated the development of theory-of-mind (ToM) knowledge in children with 'lesser variants' of autism (PDD-NOS) over a period thought to be critical for ToM development (i.e., 3 to 5 years of age). Method: The sample included 11 children with PDD-NOS; 23 normally developi

  11. Influence of female bodyweight on IVF outcome: a longitudinal multicentre cohort study of 487 infertile couples

    Pinborg, A; Gaarslev, C; Hougaard, C O;

    2011-01-01

    This study investigated the impact of women's body mass index (BMI) on the outcome after consecutive IVF/intracytoplasmic sperm injection cycles in 487 patients initiating treatment with 5-year follow-up. The total number of cycles was 1417. In total 103 (21.1%) were overweight (BMI 25-29.9 kg/m²...

  12. Directionality of the Associations of High School Expectancy-Value, Aspirations, and Attainment: A Longitudinal Study

    Guo, Jiesi; Marsh, Herbert W.; Morin, Alexandre J. S.; Parker, Philip D.; Kaur, Gurvinder

    2015-01-01

    (This study examines the directionality of the associations among cognitive assets (IQ, academic achievement), motivational beliefs (academic self-concept, task values), and educational and occupational aspirations over time from late adolescence (Grade 10) into early adulthood (5 years post high school). Participants were from a nationally…

  13. Differential Olfactory Identification in Children with Autism and Asperger's Disorder: A Comparative and Longitudinal Study

    May, Tamara; Brewer, Warrick J.; Rinehart, Nicole J.; Enticott, Peter G.; Brereton, Avril V.; Tonge, Bruce J.

    2011-01-01

    Key theories of autism implicate orbitofrontal cortex (OFC) compromise, while olfactory identification (OI) deficits are associated with OFC dysfunction. This study aimed to complete a 5-year follow-up of children with high-functioning autism (HFA) who previously lacked the normal age-OI association; and compare unirhinal-OI in children with HFA,…

  14. Re-Examining Exit Exams: New Findings from the Education Longitudinal Study of 2002

    Shuster, Kate

    2012-01-01

    Using the nationally representative, cohort-based data of the Education Longitudinal Study of 2002 (ELS:02), this study employs multiple regression to examine the effects of exit exams on student achievement and school completion. This study finds that exit exams as a whole do not have substantial effects on student achievement in mathematics,…

  15. A Longitudinal Study of Enhancing Critical Thinking and Reading Comprehension in Title I Classrooms

    VanTassel-Baska, Joyce; Bracken, Bruce; Feng, Annie; Brown, Elissa

    2009-01-01

    A longitudinal study of student growth gains was conducted in Title I schools to assess growth in reading comprehension and critical thinking. Results suggested that all students benefited from the intervention of Project Athena units of study designed for high-ability learners. In addition, the study suggested that the comparison curriculum also…

  16. A Longitudinal Investigation into L2 Learners' Cognitive Processes during Study Abroad

    Ren, Wei

    2014-01-01

    The present study longitudinally investigates the cognitive processes of advanced L2 learners engaged in a multimedia task that elicited status-equal and status-unequal refusals in English during their study abroad. Data were collected three times by retrospective verbal report from 20 Chinese learners who were studying abroad over the course of…

  17. Family and Psychosocial Risk Factors in a Longitudinal Epidemiological Study of Adolescents.

    Cuffe, Steven P.; McKeown, Robert E.; Addy, Cheryl L.; Garrison, Carol Z.

    2005-01-01

    Objective: To study the association of family and social risk factors with psychopathology in a longitudinal study of adolescents. Method: From 1986 to 1988, 3,419 seventh through ninth graders were screened with the Center for Epidemiologic Studies Depression Scale. The top decile scorers and a random sample of the remainder were interviewed…

  18. The Skinny on Body Dissatisfaction: A Longitudinal Study of Adolescent Girls and Boys

    Bearman, Sarah Kate; Presnell, Katherine; Martinez, Erin; Stice, Eric

    2006-01-01

    The present study tested whether theoretically derived risk factors predicted increases in body dissatisfaction and whether gender moderated these relations with data from a longitudinal study of 428 adolescent girls and boys because few prospective studies have examined these aims, despite evidence that body dissatisfaction increases risk for…

  19. Development of the Literacy Achievement Gap: A Longitudinal Study of Kindergarten through Third Grade

    Foster, Wayne A.; Miller, Merideth

    2007-01-01

    Purpose: The major goal of this study was to specify the developmental trajectories for phonics and early text comprehension skills of children from kindergarten through third grade. Method: Data from the Early Childhood Longitudinal Study (N = 12,261) were used in this study. The participants were divided into 3 school readiness groups based on…

  20. A Prospective, Longitudinal Study of Patient Activity Levels Following Total Knee Arthroplasty Stratified by Demographic and Comorbid Factors.

    Issa, Kimona; Jauregui, Julio J; Given, Kristin; Harwin, Steven F; Mont, Michael A

    2015-08-01

    With the marked increase in the annual number of total knee arthroplasties (TKAs) in the United States, there has been an increased interest in evaluating patient-reported outcomes. The purpose of this study was to prospectively and longitudinally evaluate temporal trends in patient activity levels following TKA and to identify potential demographic and comorbid factors that may affect these outcomes. This prospective study evaluated 281 patients, including 108 men and 173 women, who had a mean age of 66 years (39-80 years) and underwent primary TKA. All patients were followed for a minimum of 2 years. Medical comorbidities were recorded preoperatively and activity scores were evaluated at each follow-up visit. The effects of different patient demographics and systemic comorbidities on activity outcomes were further analyzed using multivariate regression analysis. Compared with preoperative levels, the activity score was observed to initially significantly decrease at 6 weeks postoperatively to below preoperative levels (9.2 vs. 8.1 points). By 3 months, scores were above preoperative levels (10.3 points), but below peak levels. A significant peak in the activity score was observed at 2-year follow-up after which there were no significant differences in scores at 5 years (11.49 vs. 11.47 points). In evaluating patient demographics and comorbidities, significant negative impact of older age, tobacco use, history of cancer, cardiovascular disease, lymphatic disease, and renal disease can be seen on activity levels. Activity scores following TKA follow a temporal trend in which scores initially drop below preoperative levels after surgery, but recover and reach a peak at 2 years postoperatively. This peak was maintained at 5-year follow-up. Surgeons should counsel their patients that they will not perceive the full benefit of a TKA until 1 to 2 years after surgery, in addition, patients may actually perceive their progress to decrease initially. Also, their

  1. Longitudinal strain from velocity encoded cardiovascular magnetic resonance: a validation study

    Heiberg Einar

    2013-01-01

    Full Text Available Abstract Background Regional myocardial function is typically evaluated by visual assessment by experienced users, or by methods requiring substantial post processing time. Visual assessment is subjective and not quantitative. Therefore, the purpose of this study is to develop and validate a simple method to derive quantitative measures of regional wall function from velocity encoded Cardiovascular Magnetic Resonance (CMR, and provide associated normal values for longitudinal strain. Method Both fast field echo (FFE and turbo field echo (TFE velocity encoded CMR images were acquired in three long axis planes in 36 healthy volunteers (13 women, 23 men, age 35±12 years. Strain was also quantified in 10 patients within one week after myocardial infarction. The user manually delineated myocardium in one time frame and strain was calculated as the myocardium was tracked throughout the cardiac cycle using an optimization formulation and mechanical a priori assumptions. A phantom experiment was performed to validate the method with optical tracking of deformation as an independent gold standard. Results There was an excellent agreement between longitudinal strain measured by optical tracking and longitudinal strain measured with TFE velocity encoding. Difference between the two methods was 0.0025 ± 0.085 (ns. Mean global longitudinal strain in the 36 healthy volunteers was −0.18 ± 0.10 (TFE imaging. Intra-observer variability for all segments was 0.00 ± 0.06. Inter-observer variability was −0.02 ± 0.07 (TFE imaging. The intra-observer variability for radial strain was high limiting the applicability of radial strain. Mean longitudinal strain in patients was significantly lower (−0.15± 0.12 compared to healthy volunteers (p Conclusion In conclusion, we have developed and validated a robust and clinically applicable technique that can quantify longitudinal strain and regional myocardial wall function and present the associated normal values

  2. Lifecourse socioeconomic status and type 2 diabetes: the role of chronic inflammation in the English Longitudinal Study of Ageing.

    Stringhini, Silvia; Zaninotto, Paola; Kumari, Meena; Kivimäki, Mika; Batty, G David

    2016-01-01

    We examined the association between lifecourse socioeconomic status (SES) and the risk of type 2 diabetes at older ages, ascertaining the extent to which adult lifestyle factors and systemic inflammation explain this relationship. Data were drawn from the English Longitudinal Study of Ageing (ELSA) which, established in 2002, is a representative cohort study of ≥50-year olds individuals living in England. SES indicators were paternal social class, participants' education, participants' wealth, and a lifecourse socioeconomic index. Inflammatory markers (C-reactive protein and fibrinogen) and lifestyle factors were measured repeatedly; diabetes incidence (new cases) was monitored over 7.5 years of follow-up. Of the 6218 individuals free from diabetes at baseline (44% women, mean aged 66 years), 423 developed diabetes during follow-up. Relative to the most advantaged people, those in the lowest lifecourse SES group experienced more than double the risk of diabetes (hazard ratio 2.59; 95% Confidence Interval (CI) = 1.81-3.71). Lifestyle factors explained 52% (95%CI:30-85) and inflammatory markers 22% (95%CI:13-37) of this gradient. Similar results were apparent with the separate SES indicators. In a general population sample, socioeconomic inequalities in the risk of type 2 diabetes extend to older ages and appear to partially originate from socioeconomic variations in modifiable factors which include lifestyle and inflammation. PMID:27101929

  3. A Longitudinal Study of Growth and Relation With Anemia and Iron Overload in Pediatric Patients With Transfusion-dependent Thalassemia.

    Nokeaingtong, Kwannapas; Charoenkwan, Pimlak; Silvilairat, Suchaya; Saekho, Suwit; Pongprot, Yupada; Dejkhamron, Prapai

    2016-08-01

    Short stature is one of the most common endocrinopathies in transfusion-dependent thalassemia (TDT). This study aimed to determine the longitudinal pattern of growth in pediatric patients with TDT and study the relationship between growth and hemoglobin level, serum ferritin level/iron overload parameters, and other clinical factors. The interval height-for-age Z-scores (HAZ) of 50 patients with TDT, of a mean age of 13.3±2.8 years, were analyzed using linear mixed model analysis. Nineteen patients (38%) had short stature with HAZ≤-2.0. The prevalence of short stature increased with age. The estimated mean HAZ decreased by 0.19 SD per year from the age of 5 years until approximately 14 years (95% confidence interval [CI], -0.22 to -0.16, Pferritin level ≥1800 ng/mL (estimate, -0.44; 95% CI, -0.59 to -0.29; P<0.001), and cardiac T2* ≤20 ms (estimate, -1.05; 95% CI, -1.34 to -0.77; P<0.001) were significantly associated with short stature. In conclusion, short stature in patients with TDT is common and relates significantly with increasing age, male sex, hemoglobin level, and iron overload status. PMID:27438019

  4. Lara Crofts Daughters? A Longitudinal Study on Female Preadolescents’ Computer Game Play and Aggressive Behavior

    Oppl, Caroline

    2010-01-01

    The current longitudinal study addresses the question about the direction of effects: Does playing (violent) electronic games increase aggressive behavior in girls over time or is it aggressive girls who increasingly seek out (and play) (violent) electronic games? This question was investigated within a longitudinal field study on children (Kinder, Computer, Hobby, Lernen = KUHL) in Berlin (Germany). The longitudinal sample of the current study included N = 169 girls who attended in the begin...

  5. Long path-length experimental studies of longitudinal phenomena in intense beams

    Beaudoin, B. L.; Haber, I.; Kishek, R. A.; Bernal, S.; Koeth, T. W.

    2016-05-01

    Intense charged particle beams are nonneutral plasmas as they can support a host of plasma waves and instabilities. The longitudinal physics, for a long beam, can often be reasonably described by a 1-D cold-fluid model with a geometry factor to account for the transverse effects. The plasma physics of such beams has been extensively studied theoretically and computationally for decades, but until recently, the only experimental measurements were carried out on relatively short linacs. This work reviews experimental studies over the past five years on the University of Maryland Electron Ring, investigating longitudinal phenomena over time scales of thousands of plasma periods, illustrating good agreement with simulations.

  6. Monitoring the Growth Dynamics of Somatic Traits Based on a Semi-longitudinal Study

    Sedlak, P.; Bláha, P.; Brabec, Marek; Vignerová, J.; Janoušek, S.; Riedlová, J.; Stříbrná, L.

    2011-01-01

    Roč. 62, č. 2 (2011), s. 144-158. ISSN 0018-442X Grant ostatní: GA MZd(CZ) NS9802 Institutional research plan: CEZ:AV0Z10300504 Keywords : semi-longitudinal study * anthropomenty * linear mixed effects model * study design Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 0.542, year: 2011

  7. Peer Contagion of Depressogenic Attributional Styles among Adolescents: A Longitudinal Study.

    Stevens, Elizabeth A.; Prinstein, Mitchell J.

    2005-01-01

    This study examined longitudinal associations between adolescents' and their friend's depressive symptoms and depressogenic attributional style. Participants included 398 adolescents in grades six through eight at the outset of the study. Adolescents completed peer nominations to identify reciprocated and unreciprocated best friendships as well as…

  8. Making Meaning of Constructivism: A Longitudinal Study of Beginning History Teachers' Beliefs and Practices

    Martell, Christopher C.

    2012-01-01

    This longitudinal interpretative case study examined the constructivist beliefs and related practices of four secondary history teachers from their teacher preparation through their first year in the classroom. The results of this study showed that issues of historical content knowledge and classroom control were major barriers for the…

  9. Language Learning at Key Stage 2: Findings from a Longitudinal Study

    Cable, Carrie; Driscoll, Patricia; Mitchell, Rosamond; Sing, Sue; Cremin, Teresa; Earl, Justine; Eyres, Ian; Holmes, Bernardette; Martin, Cynthia; Heins, Barbara

    2012-01-01

    This paper discusses some of the findings from a 3-year longitudinal study of language learning in the upper stage of English primary schools, i.e. at Key Stage 2. This largely qualitative study (commissioned by the then Department for Children, Schools and Families) was designed to explore and document developing provision and practice in a…

  10. Learning Styles and Motivational Styles in Different Academic Contexts: A Longitudinal Study

    Ozen, Rasit; Eren, Altay

    2009-01-01

    In this study, individual differences among the first year undergraduate students' learning styles and motivational styles were examined in two different academic contexts. Changes in students' learning styles and motivational styles were also investigated through a longitudinal design over one academic year. The results of this study showed that…

  11. Brain structure in bipolar disorder : A longitudinal neuroimaging study in twins

    Bootsman, F

    2016-01-01

    In this longitudinal twin study, the goal was to ascertain the extent to which BD shows abnormalities in subcortical and cortical brain regions at baseline and over time. Baseline assessments in this study revealed that BD was associated with smaller volumes of the thalamus, putamen and nucleus accu

  12. Positive Socialization Mechanisms in Secure and Insecure Parent-Child Dyads: Two Longitudinal Studies

    Kochanska, Grazyna; Woodard, Jarilyn; Kim, Sanghag; Koenig, Jamie L.; Yoon, Jeung Eun; Barry, Robin A.

    2010-01-01

    Background: Implications of early attachment have been extensively studied, but little is known about its long-term indirect sequelae, where early security organization moderates future parent-child relationships, serving as a catalyst for adaptive and maladaptive processes. Two longitudinal multi-trait multi-method studies examined whether early…

  13. Analysis of Apprenticeship Training from the National Longitudinal Study of the High School Class of 1972.

    Cook, Robert F.; And Others

    A study investigated effects of on-the-job or "hands-on" vocational training relative to standard classroom vocational instruction on subsequent employment, earnings, wages, and job satisfaction. The data used were from the National Longitudinal Study of the High School Class of 1972 and five follow-up surveys of this population. An analysis of…

  14. Longitudinal Study of Nightmares in Children: Stability and Effect of Emotional Symptoms

    Schredl, Michael; Fricke-Oerkermann, Leonie; Mitschke, Alexander; Wiater, Alfred; Lehmkuhl, Gerd

    2009-01-01

    Nightmares are defined as dreams with strong negative emotions which awaken the dreamer and are common during childhood: cross-sectional data shows the highest prevalence rates between the ages of five and ten. The present longitudinal study was designed to study the stability of nightmares over the course of 2 years. Sleep questionnaires and…

  15. Development of Working Memory and Performance in Arithmetic: A Longitudinal Study with Children

    López, Magdalena

    2014-01-01

    Introduction: This study has aimed to investigate the relationship between the development of working memory and performance on arithmetic activities. Method: We conducted a 3-year longitudinal study of a sample of 90 children, that was followed during the first, second and third year of primary school. All children were tested on measures of WM…

  16. Sleep Problems in Children with Autism Spectrum Problems: A Longitudinal Population-Based Study

    Sivertsen, Borge; Posserud, Maj-Britt; Gillberg, Christopher; Lundervold, Astri J.; Hysing, Mari

    2012-01-01

    This study examined the prevalence and chronicity of sleep problems in children who manifest problems believed to be typical of Autism Spectrum Disorders (ASD). Using data from a longitudinal total population study, symptoms of ASD, insomnia and potential explanatory factors were assessed at ages 7-9 and 11-13. Children were included in a group…

  17. Violence against Pregnant Women Can Increase the Risk of Child Abuse: A Longitudinal Study

    Chan, Ko Ling; Brownridge, Douglas A.; Fong, Daniel Y. T.; Tiwari, Agnes; Leung, Wing Cheong; Ho, Pak Chung

    2012-01-01

    Objective: To assess the impact of intimate partner violence (IPV) against pregnant women on subsequent perpetration of child abuse and neglect (CAN) by parents; and to test the mediation effect of recent IPV on the link between IPV during pregnancy and subsequent CAN. Methods: This study was a longitudinal follow-up of a population-based study on…

  18. A Longitudinal Study of the Social and Academic Competence of Economically Disadvantaged Bilingual Preschool Children

    Oades-Sese, Geraldine V.; Esquivel, Giselle B.; Kaliski, Pamela K.; Maniatis, Lisette

    2011-01-01

    This longitudinal study was conducted to gain understanding of the social-emotional and academic development of economically disadvantaged bilingual preschool children. In Study 1, the authors combined cognitive, psychosocial, and cultural-linguistic factors to determine profiles of social competence as measured by peer play. A person-centered…

  19. Power of Models in Longitudinal Study: Findings from a Full-Crossed Simulation Design

    Fang, Hua; Brooks, Gordon P.; Rizzo, Maria L.; Espy, Kimberly Andrews; Barcikowski, Robert S.

    2009-01-01

    Because the power properties of traditional repeated measures and hierarchical multivariate linear models have not been clearly determined in the balanced design for longitudinal studies in the literature, the authors present a power comparison study of traditional repeated measures and hierarchical multivariate linear models under 3…

  20. Longitudinal Associations between Externalizing Behavior and Dysfunctional Eating Attitudes and Behaviors: A Community-Based Study

    Marmorstein, Naomi R.; von Ranson, Kristin M.; Iacono, William G.; Succop, Paul A.

    2007-01-01

    This study investigated longitudinal associations between externalizing behavior and dysfunctional eating attitudes and behaviors. Participants were girls drawn from the community-based Minnesota Twin Family Study and assessed at ages 11, 14, and 17. Cross-sectional correlations indicated that the strength of the associations between externalizing…

  1. A Longitudinal Study of the Determinants and Outcomes of Career Change

    Carless, Sally A.; Arnup, Jessica L.

    2011-01-01

    The present longitudinal field study investigated the antecedents and consequences of an actual career change. The framework for this study was Rhodes and Doering's (1983) model of career change. We examined the effect of individual and organisational characteristics on career change behaviour. The individual characteristics were: traits (Openness…

  2. Early Intervention and Juvenile Delinquency Prevention: Evidence from the Chicago Longitudinal Study

    Mann, Emily A.; Reynolds, Arthur J.

    2006-01-01

    This study investigated the role of an early educational intervention and child-, family-, peer-, and school-level predictors on court-reported juvenile delinquency. Data were provided from the Chicago Longitudinal Study, an ongoing investigation of the scholastic and social development of more than 1,500 low-income youths (93% of whom were…

  3. Attention Problems in Very Preterm Children from Childhood to Adulthood: The Bavarian Longitudinal Study

    Breeman, Linda D.; Jaekel, Julia; Baumann, Nicole; Bartmann, Peter; Wolke, Dieter

    2016-01-01

    Background: Very preterm (VP; gestational age attention problems in childhood and adulthood. The stability of these problems into adulthood is not known. Methods: The Bavarian Longitudinal Study is a prospective cohort study that followed 260 VP/VLBW and 229 term-born…

  4. LIFESPAN: A Tool for the Computer-Aided Design of Longitudinal Studies

    Andreas M Brandmaier

    2015-03-01

    Full Text Available Researchers planning a longitudinal study typically search, more or less informally, a multivariate space of possible study designs that include dimensions such as the hypothesized true variance in change, indicator reliability, the number and spacing of measurement occasions, total study time, and sample size. The main search goal is to select a research design that best addresses the guiding questions and hypotheses of the planned study while heeding applicable external conditions and constraints, including time, money, feasibility, and ethical considerations. Because longitudinal study selection ultimately requires optimization under constraints, it is amenable to the general operating principles of optimization in computer-aided design. Based on power equivalence theory (MacCallum et al., 2010; von Oertzen, 2010, we propose a computational framework to promote more systematic searches within the study design space. Starting with an initial design, the proposed framework generates a set of alternative models with equal statistical power for detecting hypothesized effects, and delineates tradeoff relations among relevant parameters, such as total study time and the number of measurement occasions. We present LIFESPAN (Longitudinal Interactive Front End Study Planner that implements this framework. LIFESPAN boosts the efficiency, breadth, and precision of the search for optimal longitudinal designs. Its initial version, which is freely available at http://www.brandmaier.de/lifespan, is geared towards the power to detect variance in change as specified in a linear latent growth curve model.

  5. Etiology of Pervasive versus Situational Antisocial Behaviors: A Multi-informant Longitudinal Cohort Study

    Wertz, Jasmin; Zavos, Helena M. S.; Matthews, Timothy; Gray, Rebecca; Best-Lane, Janis; Pariante, Carmine M.; Moffitt, Terrie E.; Arseneault, Louise

    2016-01-01

    The aim of this study was to disentangle pervasive from situational antisocial behaviors using multiple informants, and to investigate their genetic and environmental etiologies in preadolescence and across time. Antisocial behaviors were assessed in 2,232 twins from the Environmental Risk (E-Risk) Longitudinal Twin Study at ages 5 and 12.…

  6. The Intergenerational Continuity of Observed Early Parenting: A Prospective, Longitudinal Study

    Kovan, Nikki M.; Chung, Alissa L.; Sroufe, L. Alan

    2009-01-01

    The authors report the results from a prospective, longitudinal study of cross-generational parenting quality in a lower socioeconomic status sample of moderate ethnic diversity (N = 61). The study extends previous research on intergenerational continuity of parenting in several significant ways: (a) Assessments in both generations were based on…

  7. A Longitudinal Study of Environmental and Outdoor Education: A Cultural Change

    Tal, Tali; Morag, Orly

    2013-01-01

    In this case-study, we present a longitudinal study of one elementary (grades 1-6) school's environmental education (EE) in order to understand the ways in which the school culture supports outdoor EE as a critical component of their science education program. The school, which was known for its school-based EE curriculum that encompasses an…

  8. How preschool executive functioning predicts several aspects of math achievement in Grades 1 and 3: A longitudinal study.

    Viterbori, Paola; Usai, M Carmen; Traverso, Laura; De Franchis, Valentina

    2015-12-01

    This longitudinal study analyzes whether selected components of executive function (EF) measured during the preschool period predict several indices of math achievement in primary school. Six EF measures were assessed in a sample of 5-year-old children (N = 175). The math achievement of the same children was then tested in Grades 1 and 3 using both a composite math score and three single indices of written calculation, arithmetical facts, and problem solving. Using previous results obtained from the same sample of children, a confirmatory factor analysis examining the latent EF structure in kindergarten indicated that a two-factor model provided the best fit for the data. In this model, inhibition and working memory (WM)-flexibility were separate dimensions. A full structural equation model was then used to test the hypothesis that math achievement (the composite math score and single math scores) in Grades 1 and 3 could be explained by the two EF components comprising the kindergarten model. The results indicate that the WM-flexibility component measured during the preschool period substantially predicts mathematical achievement, especially in Grade 3. The math composite scores were predicted by the WM-flexibility factor at both grade levels. In Grade 3, both problem solving and arithmetical facts were predicted by the WM-flexibility component. The results empirically support interventions that target EF as an important component of early childhood mathematics education. PMID:26218333

  9. Cognitive abilities underlying second-language vocabulary acquisition in an early second-language immersion education context: a longitudinal study.

    Nicolay, Anne-Catherine; Poncelet, Martine

    2013-08-01

    First-language (L1) and second-language (L2) lexical development has been found to be strongly associated with phonological processing abilities such as phonological short-term memory (STM), phonological awareness, and speech perception. Lexical development also seems to be linked to attentional and executive skills such as auditory attention, flexibility, and response inhibition. The aim of this four-wave longitudinal study was to determine to what extent L2 vocabulary acquired through the particular school context of early L2 immersion education is linked to the same cognitive abilities. A total of 61 French-speaking 5-year-old kindergartners who had just been enrolled in English immersion classes were administered a battery of tasks assessing these three phonological processing abilities and three attentional/executive skills. Their English vocabulary knowledge was measured 1, 2, and 3 school years later. Multiple regression analyses showed that, among the assessed phonological processing abilities, phonological STM and speech perception, but not phonological awareness, appeared to underlie L2 vocabulary acquisition in this context of an early L2 immersion school program, at least during the first steps of acquisition. Similarly, among the assessed attentional/executive skills, auditory attention and flexibility, but not response inhibition, appeared to be involved during the first steps of L2 vocabulary acquisition in such an immersion school context. PMID:23708731

  10. A longitudinal study of cerebral blood flow and intelligences in normal elderly people living in retirement house

    It is well known that the number of the neuron in the brain gradually reduced with advancing age, but speed of decline of brain functions differs among individuals. We have reported that social environmental factors had significant influences to cerebral blood flow (CBF) and mental function. In this paper, we report 2.5 years longitudinal study concerning with CBF and intelligences in twenty normal elderly people, mean age of 76 years old at the first measurement, living in retirement house. 1) Mean CBF measured by Xe 133 inhalation method did not alter significantly during the observation period. 2) Performance intelligence evaluated by Kohs' block design test had reduced at the point of begining but no more reduction was observed during the period. 3) Verbal intelligence evaluated by Hasegawa's intelligence scale for aged which was within normal range at the begining, slightly (-7.5 %) but significantly (p < 0.05) reduced during the period. 4) Performance intelligence tended to reduce in subjects who showed reduction of CBF. There were no significant correlation between both intelligences and CBF. CBF could be maintained even in elderly people living in retirement house which has less social stimuli during relatively short observation period in so far as they maintain active daily life. The speed of reduction of performance intelligence may be getting slow after certain age and verbal intelligence gradually decreases perhaps by disuse of the mental function. (author)

  11. Developmental changes in brain response to speech perception in late-talking children: A longitudinal MMR study.

    Chen, Yuchun; Tsao, Feng-Ming; Liu, Huei-Mei

    2016-06-01

    This study used a longitudinal design to examine the development of mismatch responses (MMRs) to Mandarin lexical tones, an index of neural speech discriminative responses, in late talkers and typical controls at 3, 5, and 6 years of age. Lexical tones are phonetic suprasegments that distinguish the lexical meanings of syllables in tonal languages. The 2 year-old late talkers were later divided into persistent language delay and late bloomer groups according to their performance on standardized language tests at 4 years. Results showed that children with persistent language delay demonstrated more positive mismatch responses than the typical controls at 3 years of age. At the age of 5, no group difference were found in the amplitude of MMRs, but the maturation of MMRs could be observed in the change of topography, with more prominent negative response in the frontal sites only in the typical group. Correlations were found between the index of MMRs at 3 years and children's language performance outcome at 6 years. Our results indicate that the development of fine-grained tone representations is delayed in late-talking children between 3 and 5 years and may be one of the underlying mechanisms which associated with later language performance. PMID:27061247

  12. Longitudinal MRI study of cortical thickness, perfusion, and metabolite levels in major depressive disorder

    Järnum, Hanna; Eskildsen, Simon Fristed; Steffensen, Elena G.;

    2011-01-01

    disorder (MDD) display morphologic, functional, and metabolic brain abnormalities in limbic-cortical regions at a baseline magnetic resonance (MR) scan and whether these changes are normalized in MDD patients in remission at a follow-up scan. Method:  A longitudinal 3.0-Tesla (T) magnetic resonance imaging......Järnum H, Eskildsen SF, Steffensen EG, Lundbye-Christensen S, Simonsen CW, Thomsen IS, Fründ E-T, Théberge J, Larsson E-M. Longitudinal MRI study of cortical thickness, perfusion, and metabolite levels in major depressive disorder. Objective:  To determine whether patients with major depressive...

  13. Simulation study of the oscillatory longitudinal motion of an airplane at the stall

    Phillips, W. H.

    1978-01-01

    Hybrid simulation of the longitudinal motion of a straight-wing airplane at the stall was studied to investigate the effect of hysteresis in the development of lift and pitching moments on the wing as a function of angle of attack on the occurrence of longitudinal oscillations at the stall. Flight data for the simulated airplane and for various other airplanes are shown for the simulated airplane and for comparison. The results show that oscillations similar to those measured in flight may be obtained by incorporating hysteresis in the lift and pitching-moment curves.

  14. The Influence of Place on Weight Gain during Early Childhood: A Population-Based, Longitudinal Study

    Carter, Megan Ann; Dubois, Lise; Tremblay, Mark S; Taljaard, Monica

    2012-01-01

    The objective of this paper was to determine the influence of place factors on weight gain in a contemporary cohort of children while also adjusting for early life and individual/family social factors. Participants from the Québec Longitudinal Study of Child Development comprised the sample for analysis (n = 1,580). A mixed-effects regression analysis was conducted to determine the longitudinal relationship between these place factors and standardized BMI, from age 4 to 10 years. The average ...

  15. Encapsulating Peritoneal Sclerosis – A 5 Year Experience

    Spence, Robert; Gillespie, Scott; Loughrey, Maurice; Gardiner, Keith

    2013-01-01

    Title Encapsulating peritoneal sclerosis – A 5 year experience Aim Encapsulating peritoneal sclerosis (EPS) is a rare, life-threatening condition, characterised by a progressive, intra-abdominal inflammatory process resulting in fibrotic visceral constriction. We report the aetiology, management, and outcome of EPS in Belfast. Method All patients diagnosed with EPS in Belfast over the past 5 years are included. Presentation, aetiology, imaging, pathology, and outcome are retrospectively analy...

  16. Education does not slow cognitive decline with aging: 12-year evidence from the victoria longitudinal study.

    Zahodne, Laura B; Glymour, M Maria; Sparks, Catharine; Bontempo, Daniel; Dixon, Roger A; MacDonald, Stuart W S; Manly, Jennifer J

    2011-11-01

    Although the relationship between education and cognitive status is well-known, evidence regarding whether education moderates the trajectory of cognitive change in late life is conflicting. Early studies suggested that higher levels of education attenuate cognitive decline. More recent studies using improved longitudinal methods have not found that education moderates decline. Fewer studies have explored whether education exerts different effects on longitudinal changes within different cognitive domains. In the present study, we analyzed data from 1014 participants in the Victoria Longitudinal Study to examine the effects of education on composite scores reflecting verbal processing speed, working memory, verbal fluency, and verbal episodic memory. Using linear growth models adjusted for age at enrollment (range, 54-95 years) and gender, we found that years of education (range, 6-20 years) was strongly related to cognitive level in all domains, particularly verbal fluency. However, education was not related to rates of change over time for any cognitive domain. Results were similar in individuals older or younger than 70 at baseline, and when education was dichotomized to reflect high or low attainment. In this large longitudinal cohort, education was related to cognitive performance but unrelated to cognitive decline, supporting the hypothesis of passive cognitive reserve with aging. PMID:21923980

  17. SALGOT - Stroke Arm Longitudinal study at the University of Gothenburg, prospective cohort study protocol

    Lundgren-Nilsson Åsa

    2011-05-01

    Full Text Available Abstract Background Recovery patterns of upper extremity motor function have been described in several longitudinal studies, but most of these studies have had selected samples, short follow up times or insufficient outcomes on motor function. The general understanding is that improvements in upper extremity occur mainly during the first month after the stroke incident and little if any, significant recovery can be gained after 3-6 months. The purpose of this study is to describe the recovery of upper extremity function longitudinally in a non-selected sample initially admitted to a stroke unit with first ever stroke, living in Gothenburg urban area. Methods/Design A sample of 120 participants with a first-ever stroke and impaired upper extremity function will be consecutively included from an acute stroke unit and followed longitudinally for one year. Assessments are performed at eight occasions: at day 3 and 10, week 3, 4 and 6, month 3, 6 and 12 after onset of stroke. The primary clinical outcome measures are Action Research Arm Test and Fugl-Meyer Assessment for Upper Extremity. As additional measures, two new computer based objective methods with kinematic analysis of arm movements are used. The ABILHAND questionnaire of manual ability, Stroke Impact Scale, grip strength, spasticity, pain, passive range of motion and cognitive function will be assessed as well. At one year follow up, two patient reported outcomes, Impact on Participation and Autonomy and EuroQol Quality of Life Scale, will be added to cover the status of participation and aspects of health related quality of life. Discussion This study comprises a non-selected population with first ever stroke and impaired arm function. Measurements are performed both using traditional clinical assessments as well as computer based measurement systems providing objective kinematic data. The ICF classification of functioning, disability and health is used as framework for the selection of

  18. Comparing Adult Productivity of American Mathematics, Chemistry, and Physics Olympians with Terman's Longitudinal Study

    Campbell, James Reed; Feng, Annie Xuemei

    2011-01-01

    In the 1950s, Terman summarized the results of his longitudinal study of the gifted and compared the "life success" of the 150 most successful men (Group A) with the 150 least successful men (Group C) at the midpoint of their careers (age 30). The objective of this article is to replicate the original Terman work with a modern sample of the most…

  19. Impact of Curriculum on Understanding of Professional Practice: A Longitudinal Study of Students Commencing Dental Education

    Kieser, Jules A.; Dall'Alba, Gloria; Livingstone, Vicki

    2009-01-01

    This longitudinal study examines changes in understanding of dental practice among a cohort of students in the early years of a dentistry programme. In their first two professional years, we identified five distinct understandings of dental practice that we have ordered from least to most comprehensive: "relieving pain or generally caring for…

  20. Change in University Teachers' Elearning Beliefs and Practices: A Longitudinal Study

    Scott, Karen M.

    2016-01-01

    Little longitudinal research has examined change in university teachers' elearning beliefs and practices after their initial experience with elearning. This study addresses this gap by focusing on six teachers who developed and implemented an elearning resource, and the changes they made to the resource and its implementation over two years. A…

  1. Early-stage cervical carcinoma, radical hysterectomy, and sexual function. A longitudinal study

    Jensen, Pernille T; Groenvold, Mogens; Klee, Marianne C;

    2004-01-01

    BACKGROUND: Limited knowledge exists concerning the impact of radical hysterectomy (RH) alone on the sexual function of patients with early-stage cervical carcinoma. The authors investigated the longitudinal course of self-reported sexual function after RH. METHODS: The current study was comprise...

  2. How Fast Do Students Forget What They Learn in Consumer Behavior? A Longitudinal Study

    Bacon, Donald R.; Stewart, Kim A.

    2006-01-01

    The retention curve for knowledge acquired in a consumer behavior course is explored in a longitudinal study, tracking individual students from 8 to 101 weeks following course completion. Rasch measurement is used to link tests and to achieve intervally scaled measures of knowledge. The findings indicate that most of the knowledge gained in the…

  3. School, Neighborhood, and Family Factors Are Associated with Children's Bullying Involvement: A Nationally Representative Longitudinal Study

    Bowes, Lucy; Arseneault, Louise; Maughan, Barbara; Taylor, Alan; Caspi, Ashalom; Moffitt, Terrie E.

    2009-01-01

    School size and problems with neighbors is associated with a greater risk of being a bullying victim while family factors such as maltreatment and domestic violence are associated with involvement in bullying. The findings are based on the Environmental Risk Longitudinal Twin Study that involves 2,232 children.

  4. Longitudinal Study of Self-Regulation, Positive Parenting, and Adjustment Problems among Physically Abused Children

    Kim-Spoon, Jungmeen.; Haskett, Mary E.; Longo, Gregory S.; Nice, Rachel.

    2012-01-01

    Objective: Research using normative and high-risk samples indicates a significant link between problems with self-regulation and child maladjustment. Nevertheless, little is known about the processes that may modify the link between self-regulation and maladjustment. This longitudinal study examined the joint contributions of child self-regulation…

  5. Relations of Television Viewing and Reading: Findings from a 4-Year Longitudinal Study

    Ennemoser, Marco; Schneider, Wolfgang

    2007-01-01

    This longitudinal study explored the long-term effects of television viewing on the development of children's reading competencies. Among 2 cohorts of German children (N[subscript 1] = 165, N[subscript 2] = 167), measures of television viewing were collected over 4 years, and tests of reading speed and reading comprehension were administered…

  6. Changing Stereotypes, Changing Grades: A Longitudinal Study of Stereotyping during a College Math Course

    Ramsey, Laura R.; Sekaquaptewa, Denise

    2011-01-01

    Previous research has illuminated an important connection between stereotypes and the performance of those targeted by a stereotype. This body of work suggests that even implicit (i.e., nonconscious and unintended) math-gender stereotyping is related to poor math performance among women. Our longitudinal study sought to measure students'…

  7. Understanding Student Stress and Coping in Elementary School: A Mixed-Method, Longitudinal Study

    Sotardi, Valerie A.

    2016-01-01

    This mixed-method, longitudinal study examined daily school stress and coping strategies of elementary schoolchildren in the United States. Students (n = 65) between the ages of 7 and 11 years reported daily school stress measures for 8 weeks and completed individual stress and coping interviews. Results highlight critical relations between…

  8. Investigation of University Students' Self-Acceptance and Learned Resourcefulness: A Longitudinal Study

    Ceyhan, A. Aykut; Ceyhan, Esra

    2011-01-01

    Self-acceptance and learned resourcefulness of university students are important concepts in coping with the environmental and developmental stressors and in the development of healthy personality. In this study, university students' self acceptance and learned resourcefulness levels were investigated longitudinally. 198 university students' self…

  9. The relationship between early sexual debut and psychosocial outcomes: a longitudinal study of Dutch adolescents

    W. Udell; T. Sandfort; E. Reitz; H. Bos; M. Dekovic

    2010-01-01

    In a longitudinal dataset of 470 Dutch adolescents, the current study examined the ways in which early sexual initiation was related to subsequent attachment, self-perception, internalizing problems, and externalizing problems. For male adolescents, analyses revealed general attachment to mother and

  10. A Longitudinal Study of the Relation between Depressive Symptomatology and Parenting Practices

    Arellano, Paula A. Errazuriz; Harvey, Elizabeth A.; Thakar, Dhara A.

    2012-01-01

    This longitudinal study examined whether mothers' depressive symptomatology predicted parenting practices in a sample of 199 mothers of 3-year-old children with behavior problems who were assessed yearly until age 6. Higher maternal depressive symptoms were associated with higher overreactivity and laxness and lower warmth when children were 6…

  11. Social Identities among Engineering Students and through Their Transition to Work: A Longitudinal Study

    Jungert, Tomas

    2013-01-01

    This article draws on a longitudinal and qualitative study of students in a master's program in engineering. Interpretative phenomenological analysis was used to analyze annual, semi-structured interviews with ten students, from the first semester until one year after graduation. The program enjoys a high status and has a reputation of being…

  12. Working Memory, Attention, and Mathematical Problem Solving: A Longitudinal Study of Elementary School Children

    Swanson, H. Lee

    2011-01-01

    The role of working memory (WM) in children's growth in mathematical problem solving was examined in a longitudinal study of children (N = 127). A battery of tests was administered that assessed problem solving, achievement, WM, and cognitive processing (inhibition, speed, phonological coding) in Grade 1 children, with follow-up testing in Grades…

  13. Behavioral Inhibition as a Risk Factor for the Development of Childhood Anxiety Disorders: A Longitudinal Study

    P.E.H.M. Muris (Peter); A.M.L. van Brakel (Anna); A. Arntz (Arnoud); E. Schouten (Erik)

    2011-01-01

    textabstractThis longitudinal study examined the additive and interactive effects of behavioral inhibition and a wide range of other vulnerability factors in the development of anxiety problems in youths. A sample of 261 children, aged 5 to 8 years, 124 behaviorally inhibited and 137 control childre

  14. Psychological Distress among Nursing, Physiotherapy and Occupational Therapy Students: A Longitudinal and Predictive Study

    Nerdrum, Per; Rustoen, Tone; Helge Ronnestad, Michael

    2009-01-01

    In this study, we present longitudinal data on changes in psychological distress among 232 Norwegian undergraduate students of nursing, physiotherapy, and occupational therapy. Psychological distress was assessed by applying the 12-item version of the General Health Questionnaire. Nursing students became substantially more distressed during the…

  15. Nutrition in adolescence. A longitudinal study in dietary patterns from teenager to adult.

    Post, G.B.

    1989-01-01

    This thesis reports the longitudinal changes in dietary intake of a group of Dutch adolescents, 103 girls and 97 boys from about 12 to 21 years of age (part of 'The Amsterdam Growth and Health Study'). The subjects were pupils of a secondary school, and measured five times. A dietary history method

  16. A longitudinal study on gross motor development in children with learning disorders

    Westendorp, Marieke; Hartman, Esther; Houwen, Suzanne; Huijgen, Barbara C. H.; Smith, Joanne; Visscher, Chris

    2014-01-01

    This longitudinal study examined the development of gross motor skills, and sex-differences therein, in 7; to 11-years-old children with learning disorders (LD) and compared the results with typically developing children to determine the performance level of children with LD. In children with LD (n

  17. Multiracial Children and Poverty: Evidence from the Early Childhood Longitudinal Study of Kindergartners

    Bratter, Jenifer; Kimbro, Rachel Tolbert

    2013-01-01

    Despite the recent growth in multiracial children among American children, we know very little about their well-being. Using the Early Childhood Longitudinal Study, Kindergarten Class (N?=?17,706), we evaluated the likelihood of living in poverty and near poverty for multiracial and monoracial children. Most multiracial groups have poverty or near…

  18. Gender Differences in the Content of Preschool Children's Recollections: A Longitudinal Study

    Tõugu, Pirko; Tulviste, Tiia; Suits, Kristi

    2014-01-01

    Personal recollections constitute autobiographical memory that develops intensively during the preschool years. The two-wave longitudinal study focuses on gender differences in preschool children's independent recollections. The same children (N = 275; 140 boys, 135 girls) were asked to talk about their previous birthday and the past weekend…

  19. Emotional Intelligence throughout Portuguese Secondary School: A Longitudinal Study Comparing Performance and Self-Report Measures

    Costa, Ana; Faria, Luísa

    2016-01-01

    This study examines the developmental trajectories of ability and trait emotional intelligence (EI) in the Portuguese secondary school. Within a three-wave longitudinal design, 395 students (M[subscript age] = 15.4; SD = 0.74) completed both the Emotional Skills and Competence Questionnaire (ESCQ) and the Vocabulary of Emotions Test (VET). Results…

  20. Effects of attitude dissimilarity and time on social integration : A longitudinal panel study

    Van der Vegt, GS

    2002-01-01

    A longitudinal panel study in 25 work groups of elementary school teachers examined the effect of attitudinal dissimilarity and time on social integration across a 9-month period. In line with the prediction based on both the similarity-attraction approach and social identity theory, cross-lagged re