Sample records for 4eme age observation

  1. Fracture num\\'erique chez les seniors du 4eme age. Observation d'une acculturation technique

    Michel, Christine; Tarpin-Bernard, Franck


    Very old people accumulate the "handicaps": social, physical, psychological or cognitive. Various research thus developed to determine there waiting and needs and also to see the benefit possibly produced by technologies (called ?gerontechnology?) on their living conditions. The object of this article is to present the numerical service offer to very old perople and to see how it takes part in a social justice according to the definition of Rawls (principle of equal freedom, principle of equal opportunity in the access). The adoption, the use and the benefit of technology are analyzed in a theoretical way through a state of the art and in an experimental way through a qualitative and quantitative investigation carried out with a population of very old people. We propose to identify dynamic technological acceptance of old people according to the TAM'S (Technology Acceptance Model) of Davis adapted by (Hamner and Qazi, 2008).

  2. Observational Search for Cometary Aging Processes

    Meech, Karen J.


    The scientific objectives of this study were (i) to search for physical differences in the behavior of the dynamically new comets (those which are entering the solar system for the first time from the Oort cloud) and the periodic comets, and (ii) to interpret these differences, if any, in terms of the physical and chemical nature of the comets and the evolutionary histories of the two comet groups. Because outer solar system comets may be direct remnants of the planetary formation processes, it is clear that the understanding of both the physical characteristics of these bodies at the edge of the planet forming zone and of their activity at large heliocentric distances, r, will ultimately provide constraints on the planetary formation process both in our Solar System and in extra-solar planetary systems. A combination of new solar system models which suggest that the protoplanetary disk was relatively massive and as a consequence comets could form at large distances from the sun (e.g. from the Uranus-Neptune region to the vicinity of the Kuiper belt), observations of activity in comets at large r, and laboratory experiments on low temperature volatile condensation, are dramatically changing our understanding of the chemical'and physical conditions in the early solar nebula. In order to understand the physical processes driving the apparent large r activity, and to address the question of possible physical and chemical differences between periodic, non-periodic and Oort comets, the PI has been undertaking a long-term study of the behavior of a significant sample of these comets (approximately 50) over a wide range of r to watch the development, disappearance and changing morphology of the dust coma. The ultimate goal is to search for systematic physical differences between the comet classes by modelling the coma growth in terms of volatile-driven activity. The systematic observations for this have been ongoing since 1986, and have been obtained over the course of

  3. Observable cosmological vector mode in the dark ages

    Saga, Shohei


    The second-order vector mode is inevitably induced from the coupling of first-order scalar modes in the cosmological perturbation theory, and might hinder a possible detection of primordial gravitational waves from inflation through 21cm lensing observations. Here, we investigate the weak lensing signal in 21cm photons emitted by neutral hydrogen atoms in the dark ages induced by the second-order vector mode, by decomposing the deflection angle of the 21cm lensing signal into the gradient and curl modes. The curl mode is a good tracer of the cosmological vector and tensor modes since the scalar mode does not induce the curl one. By comparing the angular power spectra of the 21cm lensing curl mode induced by the second-order vector mode and the primordial gravitational waves whose amplitude is parameterized by the tensor-to-scalar ratio $r$, we find that the 21cm curl mode from the second-order vector mode dominates over that from the primordial gravitational waves on almost all scales if $r \\lesssim 10^{-5}$....

  4. Aging worlds in contradiction: gerontological observations in the Mediterranean region

    Hans-Joachim von Kondratowitz


    Full Text Available This article discusses the existing and developing aging regimes in the Northern and Southern rim countries of the whole Mediterranean region which are all undergoing considerable social and political transformation processes. It is argued that several eye-opening theoretical interventions for such a gerontological project may lead to some methodological problems and pitfalls, which have to be dealt with productively. Central collective concepts of such an analysis (as the change-oriented "modernization effects" of societal aging and the continuity-oriented gaze at the "unity of the region" have to be reconsidered and ought to be more differentiated in order to allow smaller social entities (such as kinship and community systems and their connectivity to be central orientations for analyzing poverty and care management in old age in the Mediterranean region. How to reconnect such a rather micro-political agenda with large processes and big structures of aging policies in the region however still remains an open question.

  5. The age dependence of the Vega phenomenon: Observations

    Decin, G.; C. Dominik; Waters, L. B. F. M.; Waelkens, C.


    We study the time dependency of Vega-like excesses using infrared studies obtained with the imaging photopolarimeter ISOPHOT on board of ISO. We review the different studies published on this issue, and critically check and revise ages and fractional luminosities in the different samples. The conclusions of our study differ significantly from those obtained by other authors (e.g. Holland et al. 1998; Spangler et al. 2001) who suggested that there is a global power-law governing the amount of ...

  6. The age dependence of the Vega phenomenon: Observations

    Decin, G; Waters, L B F M; Waelkens, C


    We study the time dependency of Vega-like excesses using infrared studies obtained with the imaging photopolarimeter ISOPHOT on board of ISO. We review the different studies published on this issue, and critically check and revise ages and fractional luminosities in the different samples. The conclusions of our study differ significantly from those obtained by other authors (e.g. Holland et al. 1998; Spangler et al. 2001) who suggested that there is a global power-law governing the amount of dust seen in debris disks as a function of time. Our investigations lead us to conclude that (i) for stars at most ages, a large spread in fractional luminosity occurs, but (ii) there are few very young stars with intermediate or small excesses; (iii) the maximum excess seen in stars of a given age is about a fractional luminosity of approximately 10^{-3}, independent of time; and (iv) Vega-like excess is more common in young stars than in old stars.

  7. Cluster AgeS Experiment (CASE): Deficiency of observed dwarf novae in globular clusters

    Pietrukowicz, P; Schwarzenberg-Czerny, A; Thompson, I B; Pych, W; Krzeminski, W; Mazur, B


    We present the results of a search for dwarf novae (DNe) in globular clusters (GCs). It is based on the largest available homogeneous sample of observations, in terms of the time span, number of observations and number of clusters. It includes 16 Galactic GCs and yielded two new certain DNe: M55-CV1 and M22-CV2. All previously known systems located in our fields were recovered, too. We surveyed M4, M5, M10, M12, M22, M30, M55, NGC 288, NGC 362, NGC 2808, NGC 3201, NGC 4372, NGC 6362, NGC 6752, omega Cen (NGC 5139) and 47 Tuc (NGC 104). The discovery of two DNe, namely M55-CV1 and M22-CV2, was already reported by Kaluzny et al. (2005) and Pietrukowicz et al. (2005), respectively. In the remaining 14 GCs we found no certain new DNe. Our result raises the total number of known DNe in the Galactic globular clusters to 12 DNe, distributed among 7 clusters. Our survey recovered all three already known erupting cataclysmic variables (CVs) located in our fields, namely M5-V101, M22-CV1, and V4 in the foreground of M3...

  8. Mapping forest stand age in China using remotely sensed forest height and observation data

    Zhang, Chunhua; Ju, Weimin; Chen, Jing M.; Li, Dengqiu; Wang, Xiqun; Fan, Wenyi; Li, Mingshi; Zan, Mei


    Forest stand age plays a crucial role in determining the terrestrial carbon source or sink strength and reflects major disturbance information. Forests in China have changed drastically in recent decades, but quantification of spatially explicit forest age at national level has been lacking to date. This study generated a national map of forest age at 1 km spatial resolution using the remotely sensed forest height and forest type data in 2005, as well as relationships between age and height retrieved from field observations. These relationships include biomass as an intermediate parameter for major forest types in different regions of China. Biomass-height and age-biomass relationships were well fitted using field observations, with respective R2 values greater than 0.60 and 0.71 (P old in southwestern, northwestern, and northeastern areas, and young in southern and eastern regions.

  9. Incidence of cervical cancer after several negative smear results by age 50: prospective observational study

    Rebolj, Matejka; van Ballegooijen, Marjolein; Lynge, Elsebeth;


    OBJECTIVE: To determine the incidence of cervical cancer after several negative cervical smear tests at different ages. DESIGN: Prospective observational study of incidence of cervical cancer after the third consecutive negative result based on individual level data in a national registry...... of histopathology and cytopathology (PALGA). SETTING: Netherlands, national data. Population 218,847 women aged 45-54 and 445,382 aged 30-44 at the time of the third negative smear test. MAIN OUTCOME MEASURES: 10 year cumulative incidence of interval cervical cancer. RESULTS: 105 women developed cervical cancer...... within 2 595,964 woman years at risk after the third negative result at age 30-44 and 42 within 1,278,532 woman years at risk after age 45-54. During follow-up, both age groups had similar levels of screening. After 10 years of follow-up, the cumulative incidence rate of cervical cancer was similar: 41...

  10. HIV and aging: insights from the Asia Pacific HIV Observational Database (APHOD)

    Han, N; Wright, ST; O'Connor, CC; Hoy, J; Ponnampalavanar, S; Grotowski, M; Zhao, HX; Kamarulzaman, A


    Background The proportion of people living with HIV/AIDS in the ageing population (>50 years) is increasing. We aim to explore the relationship between older age and treatment outcomes in HIV-positive persons from the Asia-Pacific region. Methods Patients from the Australian HIV Observational Database (AHOD) and the TREAT Asia HIV Observational Database (TAHOD) were included in the analysis. We used survival methods to assess the association between older age and all-cause mortality, as well as time-to treatment modification. We used regression analyses to evaluate changes in CD4 counts after combination antiretroviral therapy (cART) initiation and determined the odds of detectable viral load, up to 24 months of treatment. Results A total of 7142 patients were included in these analyses (60% TAHOD, 40% AHOD), of which, 25% were >50 years old. In multivariable analyses those aged >50 were at least twice as likely to die as those aged 30-39 years [HR (50-59 years): 2.27, 95% CI: 1.34-3.83; HR (>60years) 4.28, 95% CI: 2.42-7.55]. The effect of older age on CD4 count changes was insignificant (p-trend=0.06). The odds of detectable viral load after cART initiation decreased with age (p-trend=age on time-to first treatment modification was insignificant (p-trend=0.21). We found no statistically significant differences in outcomes between AHOD and TAHOD participants for all endpoints examined. Conclusion The associations between older age and typical patient outcomes in HIV-positive patients from the Asia-Pacific region are similar in AHOD and TAHOD. Our data indicate that ‘age-effects’ traverse the resource-rich and resource-limited divide and indicate that future ageing-related findings might be applicable to each setting. PMID:25407085

  11. Reverse extraction of early-age hydration kinetic equation from observed data of Portland cement


    The early-age hydration of Portland cement paste has an important impact on the formation of microstructure and development of strength.However,manual derivation of hydration kinetic equation is very difficult because there are multi-phased,multi-sized and interrelated complex chemical and physical reactions during cement hydration.In this paper,early-age hydration kinetic equation is reversely extracted automatically from the observed time series of hydration degree of Portland cement using evolutionary computation method that combines gene expression programming and particle swarm optimization algorithms.In order to reduce the computing time,GPUs are used for acceleration in parallel.Studies have shown that according to the extracted kinetic equation,simulation curve of early-age hydration is in good accordance with the observed experimental data.Furthermore,this equation still has a good generalization ability even changing chemical composition,particle size and curing conditions.

  12. Older adults' perceptions of ageing and their health and functioning: a systematic review of observational studies.

    Warmoth, Krystal; Tarrant, Mark; Abraham, Charles; Lang, Iain A


    Many older people perceive ageing negatively, describing it in terms of poor or declining health and functioning. These perceptions may be related to older adults' health. The aim of this review was to synthesise existing research on the relationship between older adults' perceptions of ageing and their health and functioning. A systematic search was conducted of five electronic databases (ASSIA, CINAHL, IBSS, MEDLINE and PsycINFO). Citations within identified reports were also searched. Observational studies were included if they included perceptions of ageing and health-related measures involving participants aged 60 years and older. Study selection, data extraction and quality appraisal were conducted using predefined criteria. Twenty-eight reports met the criteria for inclusion. Older adults' perceptions of ageing were assessed with a variety of measures. Perceptions were related to health and functioning across seven health domains: memory and cognitive performance, physical and physiological performance, medical conditions and outcomes, disability, care-seeking, self-rated health, quality of life and death. How ageing is perceived by older adults is related to their health and functioning in multiple domains. However, higher quality and longitudinal studies are needed to further investigate this relationship. PMID:26527056

  13. Ultrasound observation of GAG content of human hip joint cartilage in different old age groups.

    Pengling Ren; Xiaofei Li; Fan Fan; Xiran Cai; He Gong; Yubo Fan; Haijun Niu


    In this study, we observed the age-related changes of glycosaminoglycan (GAG) content of human hip joint cartilage based on ultrasound (US). Seventy human hip cartilage-bone samples were collected from hip-fracture patients (ages 51 to 96) and divided into 5 groups (10 years in an age group). They were firstly measured by ultrasound to obtain quantitative acoustic parameters, including the speed of sound (SOS), US amplitude attenuation coefficient (UAA) and normalized broadband US attenuation coefficient (nBUA). Then the samples were stained for GAG with toluidine blue. Results showed SOS, UAA, nBUA decreased by 5.49%, 36.67%, 25.57% from 50-80 age group (plinear correlations between SOS and GAG optical density (r=0.825, plinear correlation to GAG optical density (r=0.688, p <; 0.07). In summary, GAG content of hip joint cartilage varied with aging in elderly people and conventional ultrasound can potentially be used to detect the age-related changes of acoustic parameters of human hip joint cartilage. PMID:26736848

  14. The Ages of A-Stars I: Interferometric Observations and Age Estimates for Stars in the Ursa Major Moving Group

    Jones, Jeremy; Boyajian, T; Schaefer, G; Baines, E; Ireland, M; Patience, J; Brummelaar, T ten; McAlister, H; Ridgway, S T; Sturmann, J; Sturmann, L; Turner, N; Farrington, C; Goldfinger, P J


    We have observed and spatially resolved a set of seven A-type stars in the nearby Ursa Major moving group with the Classic, CLIMB, and PAVO beam combiners on the CHARA Array. At least four of these stars have large rotational velocities ($v \\sin i$ $\\gtrsim$ 170 $\\mathrm{km~s^{-1}}$) and are expected to be oblate. These interferometric measurements, the stars' observed photometric energy distributions, and $v \\sin i$ values are used to computationally construct model oblate stars from which stellar properties (inclination, rotational velocity, and the radius and effective temperature as a function of latitude, etc.) are determined. The results are compared with MESA stellar evolution models (Paxton et al. 2011, 2013) to determine masses and ages. The value of this new technique is that it enables the estimation of the fundamental properties of rapidly rotating stars without the need to fully image the star. It can thus be applied to stars with sizes comparable to the interferometric resolution limit as oppose...

  15. Observational Constraints on Interacting Model of New Agegraphic Dark Energy and Alleviation of Cosmic Age Problem

    Li, Yun-He; Cui, Jing-Lei; Wang, Zhuo; Zhang, Xin


    Many dark energy models fail to pass the cosmic age test via the old quasar APM 08279+5255 at redshift $z=3.91$, even the $\\Lambda$CDM model and the holographic dark energy model are not exception. In this paper, we focus on the topic of age problem in the new agegraphic dark energy (NADE) model. We determine the age of the universe in the NADE model by using the fitting result of observational data including type Ia supernovae (SNIa), baryon acoustic oscillation (BAO) and cosmic microwave background (CMB). It is shown that the NADE model also faces the challenge of the age problem caused by the old quasar APM 08279+5255. In order to overcome such a difficulty, we consider the possible interaction between dark energy and matter. We show that the old quasar APM 08279+5255 at redshift $z=3.91$ can be successfully accommodated in the interacting new agegraphic dark energy (INADE) model at $2\\sigma$ level under the current observational constraints.

  16. Traumatic Brain Injury in Qatar: Age Matters—Insights from a 4-Year Observational Study

    Moamena El-Matbouly


    Full Text Available Background. Overall traumatic brain injury (TBI incidence and related death rates vary across different age groups. Objectives. To evaluate the incidence, causes, and outcome of TBI in adolescents and young adult population in Qatar. Method. This was a retrospective review of all TBIs admitted to the trauma center between January 2008 and December 2011. Demographics, mechanism of injury, morbidity, and mortality were analyzed in different age groups. Results. A total of 1665 patients with TBI were admitted; the majority were males (92% with a mean age of 28 ± 16 years. The common mechanism of injury was motor vehicle crashes and falls from height (51% and 35%, resp.. TBI was incidentally higher in young adults (34% and middle age group (21%. The most frequent injuries were contusion (40%, subarachnoid (25%, subdural (24%, and epidural hemorrhage (18%. The mortality rate was 11% among TBI patients. Mortality rates were 8% and 12% among adolescents and young adults, respectively. The highest mortality rate was observed in elderly patients (35%. Head AIS, ISS, and age were independent predictors for mortality. Conclusion. Adolescents and adults sustain significant portions of TBI, whereas mortality is much higher in the older group. Public awareness and injury prevention campaigns should target young population.

  17. How old is that child? Validating the accuracy of age assignments in observational surveys of vehicle restraint use

    Moeller, S; Berger, L.; J. Salvador; Helitzer, D


    Objectives: Many large scale observational studies of child restraint usage require observers to estimate the ages of the vehicle occupants. The accuracy of age assignments were assessed and possible methods to improve observational accuracy in research and field studies of child restraint use were identified.

  18. Atomic scale observation of phase transformation in long term thermally aged duplex stainless steels

    Embrittlement study of duplex stainless steels is a very important in order to predict the lifetime of primary circuits of nuclear power plant. Ferrite steels aged over 20 years, on-site, in laboratory and at different temperatures was analyzed by tomographic probe atom to assess the trend of aging of these materials with very long times. A more prospective work was also carried out, the aim was to model the decomposition of ferrite from austenitic-ferritic steels. The simulation of the decomposition of these steels are very complex, we initiated preliminary work in modelling the Fe-Cr alloys, because the decomposition of Fe and Cr in these steels is the main cause of their fragility. To validate the parameters used in simulation, an experimental study of the decomposition of an alloy Fe-20% at. Cr aged at 500 C was performed. This experimental study has shown that a non-classical germination (NCG) is involved in this alloy. The performed simulations on the same alloy at the same temperature, did not reproduce the progressive enrichment of precipitated phase a' (characteristic of NCG). The study of steels, aged over 20 years, has confirmed that the steel aged in laboratory are representative to steel aged in site ( T ≤350 C). Moreover, it has been shown that the G-phase (intermetallic precipitation at the interface a/a' phases) does not influence the embrittlement of the ferrite and the difference of thermo-mechanical treatment is not determinant of the variance decomposition observed in these steels. (author)

  19. The influence of speed, cyclists' age, pedaling frequency, and observer age on observers' time to arrival judgments of approaching bicycles and e-bikes.

    Schleinitz, Katja; Petzoldt, Tibor; Krems, Josef F; Gehlert, Tina


    Given their potential to reach higher speed levels than conventional bicycles, the growing market share of e-bikes has been the reason for increased concerns regarding road safety. Previous studies have shown a clear relationship between object approach speed and an observers' judgment of when the object would reach a predefined position (i.e., time to arrival, TTA), with higher speed resulting in longer TTA estimates. Since TTA estimates have been linked to road users' decisions of whether or not to cross or turn in front of approaching vehicles, the higher potential speeds of e-bikes might result in an increased risk for traffic conflicts. The goal of the two experiments presented in this paper was to examine the influence of speed and a variety of other factors on TTA estimation for conventional bicycles and for e-bikes. In both experiments, participants from two age groups (20-45 years old and 65 years or older) watched video sequences of bicycles approaching at different speeds (15-25km/h) and were asked to judge the TTA at the moment the video was stopped. The results of both experiments showed that an increase in bicycle approach speed resulted in longer TTA estimates (measured as the proportion of estimated TTA relative to actual TTA) for both bicycle types (ηp(2)Exp.1=.489, ηp(2)Exp.2=.705). Compared to younger observers, older observers provided shorter estimates throughout (Exp. I: MDiff=0.35, CI [0.197, 0.509], ηp(2)=.332, Exp. II: MDiff=0.50, CI [.317, 0.682], ηp(2)=.420). In Experiment I, TTA estimates for the conventional bicycle were significantly shorter than for the e-bike (MDiff=0.03, CI [.007, 0.044], ηp(2)=.154), as were the estimates for the elder cyclist compared to the younger one (MDiff=0.05, CI [.025, 0.066], ηp(2)=.323). We hypothesized that the cause for this effect might lie in the seemingly reduced pedaling effort for the e-bike as a result of the motor assistance it provides. Experiment II was able to show that a high pedaling

  20. Age and climate contribution to observed forest carbon sinks in East Asia

    Gao, Shan; Zhou, Tao; Zhao, Xiang; Wu, Donghai; Li, Zheng; Wu, Hao; Du, Ling; Luo, Hui


    The observed forest carbon sink, i.e. positive net ecosystem productivity (NEP), in East Asia reported by the eddy covariance flux tower network is an integrated result of forests themselves (e.g. age) and abiotic factors such as climate. However the relative contribution of climate alone to that sink is highly uncertain and has been in debate. In this study we de-trended a primary effect of forest age on carbon sinks by a statistical regression model between NEP and forest ages. Then, modeled residual NEP was regressed against climate factors again so that its relative contribution could be evaluated appropriately in the region. The analysis for data from the 2000s showed that forest age appeared to be the primary impact factor on the carbon sink of the region (R 2 = 0.347), and the mean annual temperature (MAT) was the second (R 2 = 0.23), while the mean annual precipitation effect might not be as apparent as MAT. Particularly for forests in China, climate might contribute to about 31.7% of the total NEP of 0.540 Pg C yr-1. Given that forests in China are relatively young under current climate conditions, we predicted that they would be capable of atmospheric carbon sequestration in the near future.


    Dadashova, G M


    Analysis of literature shows that very little data are available on gender differences and age-specific drug use in the treatment of chronic heart failure (CHF). In this work, the character of drug therapy was studied as dependent on the age and sex of patients with CHF under in-hospital observation conditions. Among hospitalized patients with CHF, an important role is played by modern drug therapy. Gender differences were found in respect of therapy with ACE inhibitors, which was used in men more frequently than in women (89 and 78%, respectively, p ACE inhibitors/ARBs (from 79.1 to 95.3%p < 0.01) and aldosterone antagonists (from 29.3 to 38.2% p < 0.001). PMID:27416677

  2. The Ages of Globular Clusters in NGC 4365 Revisited with Deep HST Observations

    Kundu, Arunav; Zepf, Stephen E.; Hempel, Maren; Morton, David; Ashman, Keith M.; Maccarone, Thomas J.; Kissler-Patig, Markus; Puzia, Thomas H.; Vesperini, Enrico


    We present new Hubble Space Telescope (HST) NIC3, near-infrared H-band photometry of globular clusters (GCs) around NGC 4365 and NGC 1399 in combination with archival HST WFPC2 and ACS optical data. We find that NGC 4365 has a number of globular clusters with bluer optical colors than expected for their red optical-to-near-infrared colors and an old age. The only known way to explain these colors is with a significant population of intermediate-age (2-8 Gyr) clusters in this elliptical galaxy. On the other hand, our result for NGC 1399 is in agreement with previous spectroscopic work that suggests that its clusters have a large metallicity spread and are nearly all old. In the literature, there are various results from spectroscopic studies of modest samples of NGC 4365 globular clusters. The spectroscopic data allow for either the presence or absence of a significant population of intermediate-age clusters, given the index uncertainties indicated by comparing objects in common between these studies and the few spectroscopic candidates with optical-to-near-IR colors indicative of intermediate ages. Our new near-IR data of the NGC 4365 GC system with a much higher signal-to-noise ratio agree well with earlier published photometry, and both give strong evidence of a significant intermediate-age component. The agreement between the photometric and spectroscopic results for NGC 1399 and other systems lends further confidence to this conclusion and to the effectiveness of the near-IR technique. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555.

  3. Influence of age and of desmotropic drugs on the step phenomenon observed in rat skin.

    Vogel, H G; Hilgner, W


    Comprehensive analysis of the mechanical properties of rat skin revealed the "step phenomenon". This particular observation was made after constant strain rate (analysis of stress strain curves) as well as after constant load (creep experiments). Relative low extensions or low loads were necessary to provoke the steps. In most cases two, sometimes three steps were observed. The step phenomenon was found mainly in skin strips punched out perpendicularly to the body axis. Probably some bonds in the fibrous network are broken giving way to additional elongation whereafter stronger links take over the stress. Since earlier studies demonstrated a pronounced influence of age and of desmotropic drugs on mechanical properties at ultimate load, e.g., tensile strength, ultimate modulus of elasticity, and ultimate strain, also the step phenomenon was studied under these conditions. In stress-strain experiments most of the steps were found at the ages of 2 and 4 months. Total stress loss and total work loss due to the steps were the highest at the age of 4 months. If, however, these values were calculated as percentage of ultimate values, the highest figures were found in young animals. Elongation gain due to the steps also showed a maximum at time of maturation, e.g., 4 months. Similar findings were achieved in creep experiments at medium load (200 g). After treatment with prednisolone acetate more steps and after treatment with D-penicillamine fewer steps were observed. In stress-strain experiments total stress loss and total work loss due to steps were more than twice as high than controls after prednisolone treatment and only one half after D-penicillamine. If calculated as percentage of ultimate stress or percentage of work input, these changes disappeared because of similar changes at ultimate load. However, elongation gain due to steps, which was not significantly influenced by prednisolone acetate but significantly decreased by D-penicillamine, showed the same changes

  4. The Age of the Directly Imaged Planet Host Star κ Andromedae Determined from Interferometric Observations

    Jones, Jeremy; White, R. J.; Quinn, S.; Ireland, M.; Boyajian, T.; Schaefer, G.; Baines, E. K.


    κ Andromedae, an early-type star that hosts a directly imaged low-mass companion, is expected to be oblate due to its rapid rotational velocity (v sin i = ˜162 km s-1). We observed the star with the CHARA Array’s optical beam combiner, PAVO, measuring its size at multiple orientations and determining its oblateness. The interferometric measurements, combined with photometry and this v sin i value are used to constrain an oblate star model that yields the fundamental properties of the star and finds a rotation speed that is ˜85% of the critical rate and a low inclination of ˜30°. Three modeled properties (the average radius, bolometric luminosity, and equatorial velocity) are compared to MESA evolution models to determine an age and mass for the star. In doing so, we determine an age for the system of {47}-40+27 Myr. Based on this age and previous measurements of the companion’s temperature, the BHAC15 evolution models imply a mass for the companion of {22}-9+8 M J.

  5. The Age of the Directly-Imaged Planet Host Star $\\kappa$ Andromedae Determined From Interferometric Observations

    Jones, Jeremy; Quinn, S; Ireland, M; Boyajian, T; Schaefer, G; Baines, E K


    $\\kappa$ Andromedae, an early type star that hosts a directly imaged low mass companion, is expected to be oblate due to its rapid rotational velocity ($v\\sin i$ = $\\sim$162 $\\mathrm{km~s^{-1}}$). We observed the star with the CHARA Array's optical beam combiner, PAVO, measuring its size at multiple orientations and determining its oblateness. The interferometric measurements, combined with photometry and this $v\\sin i$ value are used to constrain an oblate star model that yields the fundamental properties of the star and finds a rotation speed that is $\\sim$85\\% of the critical rate and a low inclination of $\\sim$30$^\\circ$. Three modeled properties (the average radius, bolometric luminosity, and equatorial velocity) are compared to MESA evolution models to determine an age and mass for the star. In doing so, we determine an age for the system of 47$^{+27}_{-40}$ Myr. Based on this age and previous measurements of the companion's temperature, the BHAC15 evolution models imply a mass for the companion of 22$^...

  6. Proportionate increase in incidence of colorectal cancer at an age below 40 years: An observation

    Pal Madhumay


    Full Text Available Aim: Colorectal cancer is particularly a disease affecting individuals above 40 years of age and 90% of cases occur in persons over the age of 50. Genetic and familial factors, viz, HNPCC and FAP, contribute to less than 20% and environmental or acquired factors are the cause of the rest. The aim of this study is to find out the relative proportion of patients Materials and Methods: Colorectal cancers registered in the calendar years of 2003 and 2004 in our institute were analyzed in this study. Data from Population Based Cancer Registry (P.B.C.R. for Bangalore, Mumbai, Delhi and Chennai for the year 1988 were taken for comparison. Results: The results show that our institute′s figures exceed the generally accepted figure for ′incidence of the disease below the age of 40 years′ by less than 10% of both the total incidence of the disease and those of P.B.C.R. for Bangalore, Mumbai and Chennai. The corresponding figure for females in Delhi P.B.C.R. shows a little similarity to our institute′s figure. Conclusion: This observation indicates a changing pattern of colorectal cancer occurrence. This change may be a regional one or may be a result of genetic or environmental changes.


    Nuclear stellar clusters (NSCs) are known to exist around massive black holes in galactic nuclei. They are thought to have formed through in situ star formation following gas inflow to the nucleus of the galaxy and/or through the infall of multiple stellar clusters. Here we study the latter, and explore the composite structure of the NSC and its relation to the various stellar populations originating from its progenitor infalling clusters. We use N-body simulations of cluster infalls and show that this scenario may produce observational signatures in the form of age segregation: the distribution of the stellar properties (e.g., stellar age and/or metallicity) in the NSCs reflects the infall history of the different clusters. The stellar populations of clusters, infalling at different times (dynamical ages), are differentially segregated in the NSC and are not fully mixed even after a few gigayears of evolution. Moreover, the radial properties of stellar populations in the progenitor cluster are mapped to their radial distribution in the final NSC, potentially leading to efficient mass segregation in NSCs, even those where relaxation times are longer than a Hubble time. Finally, the overall structures of the stellar populations present non-spherical configurations and show significant cluster to cluster population differences

  8. Observed temporal evolution of global mean age of stratospheric air for the 2002 to 2010 period

    G. P. Stiller


    Full Text Available An extensive observational data set, consisting of more than 106 SF6 vertical profiles from MIPAS measurements distributed over the whole globe has been condensed into monthly zonal means of mean age of air for the period September 2002 to January 2010, binned at 10° latitude and 1–2 km altitude. The data were analysed with respect to their temporal variation by fitting a regression model consisting of a constant and a linear increase term, 2 proxies for the QBO variation, sinusoidal terms for the seasonal and semi-annual variation and overtones for the correction of the shapes to the observed data set. The impact of subsidence of mesospheric SF6-depleted air and in-mixing into non-polar latitudes on mid-latitudinal absolute age of air and its linear increase was assessed and found to be small.

    The linear increase of mean age of stratospheric air was found to be positive and partly larger than the trend derived by Engel et al. (2009 for most of the Northern mid-latitudes, the middle stratosphere in the tropics, and parts of the Southern mid-latitudes, as well as for the Southern polar upper stratosphere. Multi-year decrease of age of air was found for the lowermost and the upper stratospheric tropics, for parts of Southern mid-latitudes, and for the Northern polar regions. Analysis of the amplitudes and phases of the seasonal variation shed light on the coupling of stratospheric regions to each other. In particular, the Northern mid-latitude stratosphere is well coupled to the tropics, while the Northern lowermost mid-latitudinal stratosphere is decoupled, confirming the separation of the shallow branch of the Brewer-Dobson circulation from the deep branch. We suggest an overall increased tropical upwelling, together with weakening of mixing barriers, especially in the Northern Hemisphere, as a hypothetical model to explain the observed pattern of linear multi-year increase/decrease, and amplitudes

  9. Estimating true age-dependence in survival when only adults can be observed: an example with Black-legged Kittiwakes

    Frederiksen, M.


    Full Text Available In long-lived birds, pre-breeders are often difficult or impossible to observe, and even though a proportion of marked adults may be of known age, the estimation of age-specific survival is complicated by the absence of observations during the first years of life. New developments in MARK now allow use of an updated individual covariate. We used this powerful approach to model age-dependence in survival of Black-legged Kittiwakes (Rissa tridactyla at a North Sea colony. Although only 69 marked breeders were of known age, there was strong evidence for a quadratic relationship between true age and survival. We believe that this simple but powerful approach could be implemented for many species and could provide improved estimates of how survival changes with age, a central theme in life history theory.

  10. Manipulateurs paralleles, 4eme partie : mode d'assemblage et cinematique directe sous forme polynomiale

    Merlet, Jean-Pierre


    Dans cette quatrieme partie, nous allons nous interesser aux developpements recents du probleme de la cinematique directe, exprimee sous forme polynomiale- , ainsi qu'a son corollaire qui est a l'etude des modes d'assemblages, a variables articulaires fixees, des robots paralleles. Dans une premiere partie, on considere les manipulateurs paralleles plans. On y montre que la cinematique directe peut toujours s'exprimer sous la forme d'un polynome mono-variable. Pour les robots planaires classi...

  11. Aging.

    Park, Dong Choon; Yeo, Seung Geun


    Aging is initiated based on genetic and environmental factors that operate from the time of birth of organisms. Aging induces physiological phenomena such as reduction of cell counts, deterioration of tissue proteins, tissue atrophy, a decrease of the metabolic rate, reduction of body fluids, and calcium metabolism abnormalities, with final progression onto pathological aging. Despite the efforts from many researchers, the progression and the mechanisms of aging are not clearly understood yet. Therefore, the authors would like to introduce several theories which have gained attentions among the published theories up to date; genetic program theory, wear-and-tear theory, telomere theory, endocrine theory, DNA damage hypothesis, error catastrophe theory, the rate of living theory, mitochondrial theory, and free radical theory. Although there have been many studies that have tried to prevent aging and prolong life, here we introduce a couple of theories which have been proven more or less; food, exercise, and diet restriction. PMID:24653904

  12. Rotation periods and seismic ages of KOIs - comparison with stars without detected planets from Kepler observations

    Ceillier, T; Garcia, R A; Metcalfe, T S; Creevey, O; Mathis, S; Mathur, S; Pinsonneault, M H; Salabert, D; Tayar, J


    One of the most difficult properties to derive for stars is their age. For cool main-sequence stars, gyrochronology relations can be used to infer stellar ages from measured rotation pe- riods and HR Diagram positions. These relations have few calibrators with known ages for old, long rotation period stars. There is a significant sample of old Kepler objects of inter- est, or KOIs, which have both measurable surface rotation periods and precise asteroseismic measurements from which ages can be accurately derived. In this work we determine the age and the rotation period of solar-like pulsating KOIs to both compare the rotation properties of stars with and without known planets and enlarge the gyrochronology calibration sample for old stars. We use Kepler photometric light curves to derive the stellar surface rotation peri- ods while ages are obtained with asteroseismology using the Asteroseismic Modeling Portal in which individual mode frequencies are combined with high-resolution spectroscopic pa- rameters. ...

  13. Sickle cell disease and age at menarche in Jamaican girls: observations from a cohort study

    Serjeant, G; A Singhal; Hambleton, I.


    AIMS—(1) To investigate the distribution of age at menarche in a representative sample of 99 patients with homozygous sickle cell (SS) disease, 69 with sickle cell haemoglobin C (SC) disease, and 100 controls with a normal haemoglobin (AA) genotype followed in a cohort study from birth. (2) To explore the determinants of the age at menarche.
METHODS—Children ascertained in a newborn screening programme were followed prospectively from birth to age 18-26.5 years with regular ...

  14. Fractional laser therapy – the next step in alleviating the symptoms of skin aging (own observations)

    Adam Halbina; Ewa Trznadel-Grodzka; Helena Rotsztejn


    Skin aging is a natural process of the skin, which accelerates in menopause and is additionally intensified by accumulating effects of repeated exposure to solar UV radiation and other external factors. Anti-aging skin treatment and constant improvement of its methods have become an important area of current research. The need to apply effective skin anti-aging methods that minimize traumatization resulted in the development of fractional laser technology delivering a laser beam to micro...

  15. Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies

    Cardwell, Chris R; Stene, Lars C; Joner, Geir; Bulsara, Max K; Cinek, Ondrej; Rosenbauer, Joachim; Ludvigsson, Johnny; Jané, Mireia; Svensson, Jannet; Goldacre, Michael J; Waldhoer, Thomas; Jarosz-Chobot, Przemyslawa; Gimeno, Suely G A; Chuang, Lee-Ming; Parslow, Roger C; Wadsworth, Emma J K; Chetwynd, Amanda; Pozzilli, Paolo; Brigis, Girts; Urbonaite, Brone; Sipetic, Sandra; Schober, Edith; Devoti, Gabriele; Ionescu-Tirgoviste, Constantin; de Beaufort, Carine E; Stoyanov, Denka; Buschard, Karsten; Patterson, Chris C


    -9) increase in childhood type 1 diabetes odds per 5-year increase in maternal age (P = 0.006), but there was heterogeneity among studies (heterogeneity I(2) = 70%). In studies with a low risk of bias, there was a more marked increase in diabetes odds of 10% per 5-year increase in maternal age. Adjustments for...... incidence of childhood type 1 diabetes in recent years could be explained by increases in maternal age....

  16. Age-Related Frontal Hyperactivation Observed across Different Working Memory Tasks: An fMRI Study

    Mohammad Fakhri


    Full Text Available Purpose: To evaluate patterns of activation, convergence and divergence of three functional magnetic resonance imaging (fMRI Working Memory (WM tasks in two different age groups. We want to understand potential impact of task and subjects’ age on WM activations as well as most important areas with regard to WM functions.

  17. Fractional laser therapy – the next step in alleviating the symptoms of skin aging (own observations

    Adam Halbina


    Full Text Available Skin aging is a natural process of the skin, which accelerates in menopause and is additionally intensified by accumulating effects of repeated exposure to solar UV radiation and other external factors. Anti-aging skin treatment and constant improvement of its methods have become an important area of current research. The need to apply effective skin anti-aging methods that minimize traumatization resulted in the development of fractional laser technology delivering a laser beam to microscopic column skin zones in order to achieve skin photo-remodeling.

  18. Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform

    Lee, Sung Sik; Avalos Vizcarra, Ima; Huberts, Daphne H. E. W.; Lee, Luke P; Heinemann, Matthias


    Important insights into aging have been generated with the genetically tractable and short-lived budding yeast. However, it is still impossible today to continuously track cells by high-resolution microscopic imaging (e.g., fluorescent imaging) throughout their entire lifespan. Instead, the field still needs to rely on a 50-y-old laborious and time-consuming method to assess the lifespan of yeast cells and to isolate differentially aged cells for microscopic snapshots via manual dissection of...

  19. GeMS MCAO observations of the Galactic globular cluster NGC 2808: the absolute age

    Massari, Davide; McConnachie, A; Bono, G; Dall'Ora, M; Ferraro, I; Iannicola, G; Stetson, P B; Turri, P; Tolstoy, E


    Globular clusters are the oldest stellar systems in the Milky Way and probe the early epoch of the Galaxy formation. However, the uncertainties on their absolute age are still too large to soundly constrain how the Galactic structures have assembled. The aim of this work is to obtain an accurate estimate of the absolute age of the globular cluster NGC 2808 using deep IR data obtained with the multi conjugate adaptive optics system operating at the Gemini South telescope (GeMS). This exquisite photometry, combined with that obtained in V and I bands with HST, allowed us the detection of the faint Main Sequence Knee feature in NGC 2808 colour magnitude diagram. The difference between this point and the main sequence turn off is a good age estimator and provides ages with unprecedented accuracy. We found that NGC 2808 has an age of t=10.9\\pm0.7 (intrinsic) \\pm0.45 (metallicity term) Gyr. A possible contamination by He-enhanced population could make the cluster up to 0.25 Gyr older. Although this age estimate agr...

  20. Observations on morphologic changes in the aging and degenerating human disc: Secondary collagen alterations

    Hanley Edward N


    Full Text Available Abstract Background In the annulus, collagen fibers that make up the lamellae have a wavy, planar crimped pattern. This crimping plays a role in disc biomechanical function by allowing collagen fibers to stretch during compression. The relationship between morphologic changes in the aging/degenerating disc and collagen crimping have not been explored. Methods Ultrastructural studies were performed on annulus tissue from 29 control (normal donors (aged newborn to 79 years and surgical specimens from 49 patients (aged 16 to 77 years. Light microscopy and specialized image analysis to visualize crimping was performed on additional control and surgical specimens. Human intervertebral disc tissue from the annulus was obtained in a prospective morphologic study of the annulus. Studies were approved by the authors' Human Subjects Institutional Review Board. Results Three types of morphologic changes were found to alter the crimping morphology of collagen: 1 encircling layers of unusual matrix disrupted the lamellar collagen architecture; 2 collagen fibers were reduced in amount, and 3 collagen was absent in regions with focal matrix loss. Conclusions Although proteoglycan loss is well recognized as playing a role in the decreased shock absorber function of the aging/degenerating disc, collagen changes have received little attention. This study suggests that important stretch responses of collagen made possible by collagen crimping may be markedly altered by morphologic changes during aging/degeneration and may contribute to the early tissue changes involved in annular tears.

  1. The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect

    Tiemann-Boege, Irene; Navidi, William; Grewal, Raji; Cohn, Dan; Eskenazi, Brenda; Wyrobek, Andrew J.; Arnheim, Norman


    The lifelong spermatogonial stem cell divisions unique to male germ cell production are thought to contribute to a higher mutation frequency in males. The fact that certain de novo human genetic conditions (e.g., achondroplasia) increase in incidence with the age of the father is consistent with this idea. Although it is assumed that the paternal age effect is the result of an increasing frequency of mutant sperm as a man grows older, no direct molecular measurement of the germ-line mutation ...

  2. Stratospheric mean ages and transport rates from observations of CO{sub 2} and N{sub 2}O

    Boering, K.A.; Wofsy, S.C.; Daube, B.C.; Schneider, H.R. [Harvard Univ., Cambridge, MA (United States). Div. of Engineering and Applied Sciences; Loewenstein, M.; Podolske, J.R. [NASA Ames Research Center, Moffett Field, CA (United States); Conway, T.J. [National Oceanic and Atmospheric Administration, Boulder, CO (United States)


    Measurements of CO{sub 2} and N{sub 2}O concentrations are reported and analyzed to investigate stratospheric transport rates. Temporal variations in tropospheric CO{sub 2} are observed to propagate into the stratosphere, showing that tropospheric air enters the lower tropical stratosphere continuously, ascends, and is transported rapidly (in less than 1 month) to both hemispheres. The mean age of stratospheric air determined from CO{sub 2} data is approximately 5 years in the mid-stratosphere. It is shown that the mean age is mathematically equivalent to a conserved tracer analogous to exhaust from stratospheric aircraft. Comparison of the mean age from models and observations indicates that current model simulations likely underestimate pollutant concentrations from proposed stratospheric aircraft by 25-100%. (author) 36 refs.

  3. Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform

    Lee, Sung Sik; Avalos Vizcarra, Ima; Huberts, Daphne H E W; Lee, Luke P; Heinemann, Matthias


    Important insights into aging have been generated with the genetically tractable and short-lived budding yeast. However, it is still impossible today to continuously track cells by high-resolution microscopic imaging (e.g., fluorescent imaging) throughout their entire lifespan. Instead, the field st

  4. Relinquishing the Practices of a Lifetime: Observations on ageing, caring and literacies

    Mary Hamilton


    Full Text Available This paper draws on ethnographic and case study data from a variety of sources to explore the changing social practices of literacy across the lifespan. It explores the new literacy demands that people encounter with age when dealing with life events in a range of social domains. These include increased leisure; travel; changing family and peer relationships as a result of death and loss; issues of health and disability and accessing new technologies. It reveals how literacy is implicated in peoples' changing sense of time, place and history; how the older person’s identity as a literate actor may be interrupted by both institutional and informal processes of caring and their disengagement from spheres of activity that were previously central markers of their identity. Ageing thus involves both expansion and retreat from familiar literacy practices.

  5. Observing Interactions between Children and Adolescents and their Parents: The Effects of Anxiety Disorder and Age

    Waite, Polly; Creswell, Catharine


    Parental behaviors, most notably overcontrol, lack of warmth and expressed anxiety, have been implicated in models of the development and maintenance of anxiety disorders in children and young people. Theories of normative development have proposed that different parental responses are required to support emotional development in childhood and adolescence, yet age has not typically been taken into account in studies of parenting and anxiety disorders. In order to identify whether associations...

  6. Acetaminophen administration in pediatric age: an observational prospective cross-sectional study

    Lubrano, Riccardo; Paoli, Sara; Bonci, Marco; Di Ruzza, Luigi; Cecchetti, Corrado; Falsaperla, Raffaele; Pavone, Piero; Matin, Nassim; Vitaliti, Giovanna; Gentile, Isotta


    Background Parents often do not consider fever as an important physiological response and mechanism of defense against infections that leads to inappropriate use of antipyretics and potentially dangerous side effects. This study is designed to evaluate the appropriateness of antipyretics dosages generally administered to children with fever, and to identify factors that may influence dosage accuracy. Results In this cross-sectional study we analyzed the clinical records of 1397 children aged ...

  7. The Ages of Globular Clusters in NGC 4365 Revisited with Deep HST Observations

    Kundu, A; Hempel, M; Morton, D; Ashman, K M; Maccarone, T J; Kissler-Patig, M; Puzia, T; Vesperini, E; Kundu, Arunav; Zepf, Stephen E.; Hempel, Maren; Morton, David; Ashman, Keith M.; Maccarone, Thomas J.; Kissler-Patig, Markus; Puzia, Thomas H.; Vesperini, Enrico


    We present new Hubble Space Telescope (HST)-NIC3, near-infrared H-band photometry of globular clusters (GC) around NGC 4365 and NGC 1399 in combination with archival HST-WCPC2 and ACS optical data. We find that NGC 4365 has a number of globular clusters with bluer optical colors than expected for their red optical to near-infrared colors and an old age. The only known way to explain these colors is with a significant population of intermediate-age (2-8 Gyr) clusters in this elliptical galaxy. In contrast, NGC 1399 reveals no such population. Our result for NGC 1399 is in agreement with previous spectroscopic work that suggests that its clusters have a large metallicity spread and are nearly all old. In the literature, there are various results from spectroscopic studies of modest samples of NGC 4365 globular clusters. The spectroscopic data allow for either the presence or absence of a significant population of intermediate-age clusters, given the index uncertainties indicated by comparing objects in common b...

  8. 1-6 Years Aged Childrens Mothers First Aid for Burns Observation in Mardin City Center

    Betul Battaloglu Inanc


    Full Text Available        Aim: In this study, we aimed to determine the mothers’ knowledge levels about burns and first aid. When they encounter burns, what will they do in the first instance and emergency application. At the end of this research correct information given to mothers. Aimed to supply the deficiency information. Material and Method: 25-49 age group of mothers who have 1-6 years aged childrens’ in the study were choisen ramdomly. After being informed about the study, only volunteries for questionnaires were used. There were a thousand mothers. Results: Children’ 21.6 % have burns. 81.4% burns were in their house , 18.6 % burns were out of their house. Often burns case were 2-4 years aged group children. 89.6 % mothers found themselves have no true knowledge about first aid for burns. Discussion: Mothers’ knowledge more deficient about the first aid for the burns. In this regard mothers’ lack of knowledge must be correct with the training activities to be applied. Prime necessity of the mothers were informed about the right applications.

  9. Muscleblind-like 3 deficit results in a spectrum of age-associated pathologies observed in myotonic dystrophy.

    Choi, Jongkyu; Dixon, Donald M; Dansithong, Warunee; Abdallah, Walid F; Roos, Kenneth P; Jordan, Maria C; Trac, Brandon; Lee, Han Shin; Comai, Lucio; Reddy, Sita


    Myotonic dystrophy type I (DM1) exhibits distinctive disease specific phenotypes and the accelerated onset of a spectrum of age-associated pathologies. In DM1, dominant effects of expanded CUG repeats result in part from the inactivation of the muscleblind-like (MBNL) proteins. To test the role of MBNL3, we deleted Mbnl3 exon 2 (Mbnl3(ΔE2)) in mice and examined the onset of age-associated diseases over 4 to 13 months of age. Accelerated onset of glucose intolerance with elevated insulin levels, cardiac systole deficits, left ventricle hypertrophy, a predictor of a later onset of heart failure and the development of subcapsular and cortical cataracts is observed in Mbnl3(ΔE2) mice. Retention of embryonic splice isoforms in adult organs, a prominent defect in DM1, is not observed in multiple RNAs including the Insulin Receptor (Insr), Cardiac Troponin T (Tnnt2), Lim Domain Binding 3 (Ldb3) RNAs in Mbnl3(ΔE2) mice. Although rare DM1-like splice errors underlying the observed phenotypes cannot be excluded, our data in conjunction with the reported absence of alternative splice errors in embryonic muscles of a similar Mbnl3(ΔE2) mouse by RNA-seq studies, suggest that mechanisms distinct from the adult retention of embryonic splice patterns may make important contributions to the onset of age-associated pathologies in DM1. PMID:27484195

  10. Drying effect on cement paste porosity at early age observed by NMR methods

    FAURE, Paméla; CARE, Sabine; Magat, Julie; Chaussadent, Thierry


    Nuclear Magnetic Resonance (NMR) methods (imaging and relaxation time) allow studying water content and porous network in cementitious materials. Hydration of cement pastes with two water to cement ratios (W/C of 0.4 and 0.45) has been studied under two conditions (with drying or without drying) at early age. The objectives of this study were, firstly to determine the water content and the drying mechanisms with Magnetic Resonance Imaging (MRI) and to validate this result with oven-drying met...

  11. The life experience and status of Chinese rural women from observation of three age groups.

    Dai, K


    Interview data gathered during 2 surveys in Anhui and Shejiang Provinces in 1986 and 1987 are used to depict changes in the social status and life situation of rural women in China in 3 age groups, 18-36, 37-55, and 56 and over. For the younger women, marriage increasingly is a result of discussion with parents, not arrangement, but 3rd-party introductions are increasing. They are active in household and township enterprises and aspire to more education and economic independence. The middle-aged group experienced war and revolution and now work nonstop under the responsibility system of household production, aspiring to university education for sons and enterprise work for daughters. The older women, while supported by their sons, live a frugal existence. In general, preference for sons is still prevalent and deep-seated. At the same time, the bride price and costs of marriage are increasing and of widespread concern. Rural socioeconomic growth is required before Confucian traditions are overcome. PMID:12179888

  12. Ice formation and development in aged, wintertime cumulus over the UK : observations and modelling

    I. Crawford


    Full Text Available In-situ high resolution aircraft measurements of cloud microphysical properties were made in coordination with ground based remote sensing observations of Radar and Lidar as part of the Aerosol Properties, PRocesses And InfluenceS on the Earth's climate (APPRAISE project. A narrow but extensive line (~100 km long of shallow convective clouds over the southern UK was studied. Cloud top temperatures were observed to be higher than ~−8 °C, but the clouds were seen to consist of supercooled droplets and varying concentrations of ice particles. No ice particles were observed to be falling into the cloud tops from above. Current parameterisations of ice nuclei (IN numbers predict too few particles will be active as ice nuclei to account for ice particle concentrations at the observed near cloud top temperatures (~−7 °C. The role of biological particles, consistent with concentrations observed near the surface, acting as potential efficient high temperature IN is considered important in this case. It was found that very high concentrations of ice particles (up to 100 L−1 could be produced by powerful secondary ice particle production emphasising the importance of understanding primary ice formation in slightly supercooled clouds.

    Aircraft penetrations at −3.5 °C, showed peak ice crystal concentrations of up to 100 L−1 which together with the characteristic ice crystal habits observed (generally rimed ice particles and columns suggested secondary ice production had occurred. To investigate whether the Hallett-Mossop (HM secondary ice production process could account for these observations, ice splinter production rates were calculated. These calculated rates and observations could only be reconciled provided the constraint that only droplets >24 μm in diameter could lead to splinter production, was relaxed slightly by 2 μm.

    Model simulations of the case study were also performed with the WRF

  13. In situ observation of reversible domain switching in aged Mn-doped BaTiO3 single crystals

    Zhang, L. X.; Ren, X.


    Very recently, a giant recoverable electrostrain effect has been found in aged Fe-doped BaTiO3 single crystals; this effect is based on a defect-mediated reversible domain-switching mechanism. However, the reversible domain-switching process itself is yet to be directly verified. In the present study, we performed in situ domain observation during electric field cycling for an aged Mn-doped BaTiO3 single crystal and simultaneously measured its polarization (P) -field (E) hysteresis loop. In addition, the electrostrain behavior of the sample was also characterized. Such experimentation made it possible to correlate the mesoscopic domain-switching behavior with the macroscopic properties. It was found that the aged sample shows a remarkable reversible domain switching during electric field cycling; it corresponds very well to a “double” hysteresis loop and a giant recoverable electrostrain effect (with a maximum strain of 0.4%). This provides direct mesoscopic evidence for our reversible domain-switching mechanism. By contrast, an unaged sample shows irreversible domain-switching behavior during electric field cycling; it corresponds to a normal hysteresis loop and a butterfly-type irrecoverable electrostrain behavior. This indicates that the reversible domain switching in the aged sample is related to point-defect migration during aging. We further found that the large recoverable strain is available over a wide frequency range. This is important for the application of this electrostrain effect.

  14. Exploring Tree Age & Diameter to Illustrate Sample Design & Inference in Observational Ecology

    Casady, Grant M.


    Undergraduate biology labs often explore the techniques of data collection but neglect the statistical framework necessary to express findings. Students can be confused about how to use their statistical knowledge to address specific biological questions. Growth in the area of observational ecology requires that students gain experience in…

  15. An observation study on the effects of queen age on some characteristics of honey bee colonies

    Ibrahim Çakmak


    Full Text Available This study was conducted to determine the effects of the queen’s age on performance of the honeybee (A. mellifera anatoliaca colonies at nomad beekeeping conditions. Performances of the colonies, which had 0, 1, 2 and 3 year-old queens, were compared. The number of combs, brood areas, wintering ability survival rate and honey yield were determined as performance criteria. The average number of combs with bees throughout the experiment in Group I, Group II, Group III and Group IV was 10.92±0.78, 14.68±0.55, 10.10±0.60, 7.88±0.45 number combs/colony; the average of brood areas was 3078±372.5 cm2, 3668±460.3 cm2, 2215±294.0 cm2, 1665.38±241.8 cm2; the average of wintering ability was 84.3±2.9%, 88.0±3.7%, 46.6±19.0%, 26.8±16.5%; the survival rate was 100%, 100%, 60%, 40%; and the average of honey yields was 31.4±1.89 kg, 41.5±1.05 kg, 20.4±2.62 kg and 12.0±1.41 kg per colony, respectively. A significant and negative correlation between queen age and brood production (r=-80.2, colony strength (r=-62.5, wintering ability (r=-66 and honey yield (r=-75.6 were calculated (P<0.01. The colonies headed by young queens had more brood areas, longer worker colony population, better wintering ability and greater honey yield in comparison to colonies headed by old queens.

  16. Direct observation of aerosol particles in aged agricultural biomass burning plumes impacting urban atmospheres

    W. Y. Li


    Full Text Available Emissions from agricultural biomass burning (ABB in northern China have a significant impact on the regional and the global climate. According to the Giovanni's Aerosol optical depth (AOD map, the monthly average AOD at 550 nm in northern China in 2007 shows a maximum value of 0.7 in June, suggesting that episodes of severe aerosol pollution occurred in this region. Aerosol particles were collected in urban Beijing during regional brown hazes from 12 to 30 June, 2007. Transmission electron microscopy with energy-dispersive X-ray spectrometry characterized the morphology, composition, and mixing state of aerosol particles. Potassium salts (K2SO4 and KNO3, ammonium sulfate, soot, and organic particles predominated in fine particles (diameter <1 μm collected from 12 to 20 June, 2007. In contrast, from 21 to 30 June, 2007, ammonium sulfate, soot, and organic particles were dominant. Potassium-dominant particles as a tracer of biomass burning, together with wildfire maps, show that intensive regional ABB in northern China from 10 to 20 June, 2007 contributed significantly to the regional haze. After long-range transport, ABB particles exhibited marked changes in their morphology, elemental composition, and mixing state. Heterogeneous reactions completely converted KCl particles from ABB into K2SO4 and KNO3. Soot particles were generally mixed with potassium salts, ammonium salts, and organic particles. In addition, the abundant aged organic particles and soluble salts emitted by ABB become more hygroscopic and increase their size during long-range transport, becoming in effect additional cloud condensation nuclei. The high AOD (average value at 2.2 during 12 to 20 June, 2007, in Beijing is partly explained by the hygroscopic growth of aged fine aerosol particles and by the strong absorption of internally mixed soot particles, both coming from regional ABB emissions.

  17. [A study on observation of bone metabolism in middle-aged and senile female Graves' disease].

    Zhu, L Q; Liu, Y H; Zhou, Y B


    Sixty-nine cases of middle aged and senile female Graves' desease (GD) patients suffered from abnormal bone metabolism have been studied. They were divided randomly into group A and B, treated separately with antithyroid drugs (Tapazol and inderal, etc.) in group A, and added with Chinese herbal medicine for tonifying Kidney and promoting blood circulation in group B. Before treatment, patients of both groups showed obvious higher blood calcium (Ca) 24-hour urinary Ca, phosphorus (P) and serum clcitonin (CT) levels than that in normal subjects. These patients' serum Ca, moreover, had a parallel relationship with serum T3 levels (r = 0.6142, P < 0.01) and the serum Ca also a paralleled with serum CT levels (r = 0.5714, P < 0.05). After six months of treatment, the serum Ca, 24-hour urinary Ca, P and blood CT values were all reduced in various degree. The decrease of these bone metabolic parameters were more significant in group B than that in group A. PMID:9387746

  18. An observational study of comorbidity and healthcare utilisation among HIV-positive patients aged 50 years and over.

    Patel, Roshani; Moore, Thomas; Cooper, Vanessa; McArdle, Conor; Perry, Nicky; Cheek, Elizabeth; Gainsborough, Nicola; Fisher, Martin


    The number of HIV-positive people aged ≥50 years is rising each year. We measured the prevalence of non-infectious illnesses and their risk factors and described healthcare use in this UK population. A cross-sectional, observational study was conducted at an outpatient HIV specialist clinic in south east England. Patients age ≥50 years were invited to complete questionnaires measuring demographics, non-infectious illnesses, medication use, lifestyle and healthcare utilisation. The response rate was 67%. Of 299 participants, 84% reported ≥1 comorbid condition and 61% reported ≥2 (multimorbidity). Most commonly reported were high cholesterol, sexual dysfunction, hypertension and depression. In multivariate analyses, age, number of years HIV-positive and duration of antiretroviral therapy remained significant predictors of comorbidity when controlling for lifestyle factors (exercise, smoking and use of recreational drugs and alcohol). Use of non-HIV healthcare services was associated with increasing comorbidity, a longer duration of HIV and recreational drug use. The majority of HIV-patients aged ≥50 years reported multiple comorbidities and this was associated with polypharmacy and increased use of non-HIV services. Further research examining the quality, safety and patient experience of healthcare is needed to inform development of services to optimally meet the needs of older HIV-positive patients. PMID:26068965

  19. Intra- and inter-observer variation in histological criteria used in age at death determination based on femoral cortical bone

    Lynnerup, N; Thomsen, J L; Frohlich, B


    been carried out dealing with the intra- and inter-observer error. Furthermore, when such studies have been completed, the statistical tools for assessing variability have not been adequate. This study presents the results of applying simple quantitative statistics on several counts of microscopic......, precluding the use of osteon fragments and Haversian canals. The observers in this study included experienced and inexperienced users of the microscopic method, yet the variability was uniformly large for all observers, suggesting fundamental problems in definition and identification of the structural......The microscopic method of age at death determination was introduced by Kerley in 1965. The method, which relies on the quantification of selected elements in cortical bone tissue, has been widely used, and several other researchers have modified or added to the method. Yet, very few studies have...

  20. Techniques of the environmental observer: India's earth remote sensing program in the age of global information

    Denicola, Lane A.

    This research examines the emergence in India of earth remote sensing (ERS), a principal medium for environmental analysis, communication, and policy-making. ERS---the science and "craft" of analyzing images of terrestrial phenomena collected by aircraft or satellite---constitutes an information technology whose predominance in environmental discourse has grown continuously since first proposed for such applications by American researchers in 1962. Raising many thorny issues in information access and control, the use and popularization of ERS has intensified dramatically since the mid-1980s. In Westernized discourse (both popular and expert), space research and industry are often depicted at a double-remove from the so-called "developing world," where exotic technologies and esoteric goals are overshadowed by patent human needs and a lack of basic infrastructure. Yet advocates hail the utility of ERS in socially relevant applications, and India has amassed upwards of five decades of experience in space, with systems and products rivaled today only by those of the United States and China. A multi-sited ethnography of a nascent visual medium, the dissertation triangulates on its topic by tracing three analytical threads: (1) a diachronic analysis of Indian ERS satellites as an allegory of statehood and participation in the global present, (2) a synchronic analysis of ERS imagery as a discursive artifact and global information commodity, and (3) an analysis of interpretive practice as observed through a single class of Indian and foreign students at the Indian Institute of Remote Sensing (IIRS), considered here as an "interpretive community" of environmental experts. The dissertation is the result of four years of research with ERS students, faculty, researchers, users and administrators in the U.S., the U.K., Turkey and India. In particular, I conducted nine months of ethnographic fieldwork in India in 2002 and 2005, the latter half of which was spent in participant-observation

  1. Probing the dark ages: Observations of the high-redshift universe

    Stevens, Daniel Keith

    This thesis attempts to describe some of the earliest phases in the collapse of galaxies from an observational standpoint. The work is composed of an assortment of projects which sample objects at very high redshift, probing the Universe 1-3 Gyr after the Big Bang. The first section of the thesis concerns high-redshift galaxies. Search techniques for identifying distant galaxies are extensively reviewed. Radio selection was once the primary vehicle to targeting the early Universe. Keck spectroscopy of high-redshift radio galaxies from the MIT-Greenbank radio catalog (S5GHz >~ 50 mJy) are discussed. We synthesize a composite radio galaxy spectrum, which we compare with other composite active galaxy spectra. Our data suggests a correlation between radio power and ionization state in high-redshift radio galaxies. The following three chapters detail individual galaxies confirmed at z > 5. These galaxies are among the half-dozen most distant sources known at the close of the 20th Century. Two of the galaxies were photometrically-selected from the Hubble Deep Field (HDF 4-473.0 at z = 5.60 and HDF 3-951.0 at z = 5.34 +/- 0.01). The third is TN J0924-2201, a radio galaxy at z = 5.19 selected on the basis of steep radio spectral index and faint K-band brightness. This source contains the most distant active galactic nucleus currently known, requiring early formation of supermassive blackholes within a Gyr after the Big Bang. The second section of the thesis concerns searches for high-redshift Lyα emission, identified either from deep, narrow-band imaging surveys or deep slit spectra. We discuss in detail one faint, high equivalent width line-emitter. Conventional wisdom would suggest identifying the 9185 Å line with Lyα at z = 6.55. We argue [O II] λ3727 at z = 1.46 is the more likely identification and discuss observational tests to distinguish Lyα-emitters at high redshift from foreground (active) sources. The final section of the thesis concerns high

  2. Neurobehavioral observation and hearing impairment in children at school age in eastern Slovakia

    Sovcikova, E.; Trnovec, T.; Petrik, J.; Kocan, A.; Drobna, B.; Wimmerova, S.; Wsolova, L. [Slovak Medical Univ., Bratislava (Slovakia); Hustak, M. [Air Force Military Hospital, Kosice (Slovakia)


    Neurotoxicity of PCBs has been reported in humans and confirmed in animal studies. It was shown that PCBs can alter a number of developmental physiological processes in which the thyroid plays an essential role. In children, the prenatal exposure to PCBs was associated with reduced birth weight and poor recognition memory. In children with longer duration of breast feeding implying higher PCB exposure, altered behavior, lengthening of psychomotor activities, worse attention, and worse memory performance were found. The so far published data on the association between PCBs exposure and hearing were based mainly on animal observations. Low-frequency auditory impairments have been documented in PCB exposed rats, including elevated behavioral auditory thresholds, decreased amplitude and prolonged latency auditory evoked brain stem responses. Two papers were related to humans only. The first one reported PCB-associated increased thresholds at two out of eight frequencies on audiometry, but only on the left side, and no deficits on evoked potentials or contrast sensitivity in 7-year-old children prenatally exposed to seafood neurotoxicants. The other paper was focused on hearing impairments in boys of fish-eating mothers, but no individual PCB exposure data were available. The aim of this study was to evaluate the associations between exposure to PCBs and health outcomes assessed, as performance in neurobehavioral tests, thyroid hormones production and hearing status. Selected confounder factors such as heavy metals and health/social background of development in children were also taken into consideration.

  3. Observations of parent reactions to sex-stereotyped behaviors: age and sex effects.

    Fagot, B I; Hagan, R


    To examine differential socialization of boys and girls by mothers and fathers, home observations were completed for families of 92 12-month-old children, 82 18-month-old children, and 172 5-year-old children. Mothers gave more instructions and directions than did fathers, while fathers spent more time in positive play interaction. Differences in parents' reactions to 12- and 18-month boys and girls were as expected, with the exception that boys received more negative comment for communication attempts than did girls. The suggestion in the literature that fathers would be more involved in sex typing than mothers was not confirmed in this study. The only 2 significant sex-of-parent x sex-of-child effects occurred at 18 months; fathers gave fewer positive reactions to boys engaging in female-typical toy play, and mothers gave more instruction to girls when they attempted to communicate. We argue that the second year of life is the time when children are learning many new skills and when parents are still experimenting with parenting styles and may well use stereotypical responses when unsure of themselves. PMID:1914629

  4. Differences in oral sexual behaviors by gender, age, and race explain observed differences in prevalence of oral human papillomavirus infection.

    Gypsyamber D'Souza

    Full Text Available PURPOSE: This study explores whether gender, age and race differences in oral sexual behavior account for the demographic distribution of oral human papillomavirus infection (HPV and HPV-positive oropharyngeal cancer (HPV-OSCC. METHODS: This analysis included 2,116 men and 2,140 women from NHANES (2009-10 who answered a behavioral questionnaire and provided an oral-rinse sample for HPV detection. Weighted prevalence estimates and prevalence ratios (PR were calculated for sexual behaviors and oral HPV infection by gender, age-cohort (20-29, 30-44, 45-59, 60-69, and race, and contrasted with incidence rate ratios (IRR of OSCC from SEER 2009. Multivariate logistic regression was used to evaluate predictors of oral sexual behavior and oral HPV16 infection. RESULTS: Differences in oral sexual behavior were observed by gender, age-cohort and race. Most men (85.4% and women (83.2% had ever performed oral sex, but men had more lifetime oral and vaginal sexual partners and higher oral HPV16 prevalence than women (each p<0.001. 60-69 year olds (yo were less likely than 45-59 or 30-44 (yo to have performed oral sex (72.7%, 84.8%, and 90.3%, p<0.001, although oral HPV16 prevalence was similar. Prevalence ratios (PR of ever oral sex in men vs. women (PR = 1.03, and 45-59 vs. 30-44 year-old men (PR = 0.96 were modest relative to ratios for oral HPV16 infection (PRs = 1.3-6.8 and OSCC (IRR = 4.7-8.1. In multivariate analysis, gender, age-cohort, and race were significant predictors of oral sexual behavior. Oral sexual behavior was the primary predictor of oral HPV16 infection; once this behavior was adjusted for, age-cohort and race were no longer associated with oral HPV16. CONCLUSION: There are differences in oral sexual behaviors when considering gender, age-cohort and race which explain observed epidemiologic differences in oral HPV16 infection across these groups.

  5. First Observational Signature of Rotational Deceleration in a Massive, Intermediate-age Star Cluster in the Magellanic Clouds

    Wu, Xiaohan; de Grijs, Richard; Deng, Licai


    While the extended main-sequence turn-offs (eMSTOs) found in almost all 1--2 Gyr-old star clusters in the Magellanic Clouds are often explained by postulating extended star-formation histories, the tight subgiant branches (SGBs) seen in some clusters challenge this popular scenario. Puzzlingly, the SGB of the eMSTO cluster NGC 419 is significantly broader at bluer than at redder colors. We carefully assess and confirm the reality of this observational trend. If we would assume that the widths of the features in color--magnitude space were entirely owing to a range in stellar ages, the star-formation histories of the eMSTO stars and the blue SGB region would be significantly more prolonged than that of the red part of the SGB. This cannot be explained by assuming an internal age spread. We show that rotational deceleration of a population of rapidly rotating stars, a currently hotly debated alternative scenario, naturally explains the observed trend along the SGB. Our analysis shows that a `converging' SGB cou...

  6. Long-Term Changes in Stratospheric Age Spectra in the 21st Century in the Goddard Earth Observing System Chemistry-Climate Model (GEOSCCM)

    Li, Feng; Waugh, Darryn W.; Douglass, Anne R.; Newman, Paul A.; Strahan, Susan E.; Ma, Jun; Nielsen, J. Eric; Liang, Qing


    In this study we investigate the long-term variations in the stratospheric age spectra using simulations of the 21st century with the Goddard Earth Observing System Chemistry- Climate Model (GEOSCCM). Our purposes are to characterize the long-term changes in the age spectra and identify processes that cause the decrease of the mean age in a warming climate. Changes in the age spectra in the 21st century simulations are characterized by decreases in the modal age, the mean age, the spectral width, and the tail decay timescale. Our analyses show that the decrease in the mean age is caused by two processes: the acceleration of the residual circulation that increases the young air masses in the stratosphere, and the weakening of the recirculation that leads to the decrease of tail of the age spectra and the decrease of the old air masses. The weakening of the stratospheric recirculation is also strongly correlated with the increase of the residual circulation. One important result of this study is that the decrease of the tail of the age spectra makes an important contribution to the decrease of the main age. Long-term changes in the stratospheric isentropic mixing are investigated. Mixing increases in the subtropical lower stratosphere, but its impact on the age spectra is outweighed by the increase of the residual circulation. The impacts of the long-term changes in the age spectra on long-lived chemical traces are also investigated. 37 2

  7. Amputations and foot ulcers in patients newly diagnosed with Type 2 diabetes mellitus and observed for 19 years. The role of age, gender and co-morbidity

    Bruun, C; Siersma, V.; Guassora, A.D.;


    To determine the prevalence of foot ulcers and the incidence of amputations in patients with Type 2 diabetes observed for 19 years after diagnosis. We investigated the role of gender, age and co-morbidities.......To determine the prevalence of foot ulcers and the incidence of amputations in patients with Type 2 diabetes observed for 19 years after diagnosis. We investigated the role of gender, age and co-morbidities....

  8. Hydrological evidence for a North Atlantic oscillation during the Little Ice Age outside its range observed since 1850

    C. Martín-Puertas


    Full Text Available An annual-resolved precipitation reconstruction for the last 800 yr in Southern Spain has been performed using stable carbon isotope (δ13C of Pinus nigra tree rings. The reconstruction exhibits high- to low-frequency variability and distinguishes a Little Ice Age (LIA, AD 1350–1850 characterized by lower averaged rainfall than both in the transition from the Medieval Climate Anomaly to the LIA and in the 20th century. The driest conditions are recorded during the Maunder solar Minimum (mid 17th–early 18th centuries, in good agreement with the Spanish documentary archive. Similar linkage between solar activity (maximum/minimum and precipitation (increase/decrease is observed throughout the entire LIA. Additionally, the relationship between the hydrological pattern in the Iberian Peninsula and Morocco during the LIA suggests different spatial distribution of precipitation in the south-eastern sector of the North Atlantic region such as it is known currently. Whereas in the instrumental record the precipitation evolves similarly in both regions and opposite to the North Atlantic oscillation (NAO index, the coldest periods of the LIA shows a contrasting pattern with drier conditions in the South of Spain and wetter in Northern Africa. We suggest an extreme negative NAO conditions, accompanied by a southward excursion of the winter rainfall band beyond that observed in the last century, can explain this contrast. The sustained NAO conditions could have been triggered by solar minima and higher volcanic activity during the LIA.

  9. The Luminosity, Mass, and Age Distributions of Compact Star Clusters in M83 Based on HST/WFC3 Observations

    Chandar, Rupali; Kim, Hwihyun; Kaleida, Catherine; Mutchler, Max; Calzetti, Daniela; Saha, Abhijit; O'Connell, Robert; Balick, Bruce; Bond, Howard; Carollo, Marcella; Disney, Michael; Dopita, Michael A; Frogel, Jay A; Hall, Donald; Holtzman, Jon A; Kimble, Randy A; McCarthy, Patrick; Paresce, Francesco; Silk, Joe; Trauger, John; Walker, Alistair R; Windhorst, Rogier A; Young, Erick


    The newly installed Wide Field Camera 3 (WFC3) on the Hubble Space Telescope has been used to obtain multi-band images of the nearby spiral galaxy M83. These new observations are the deepest and highest resolution images ever taken of a grand-design spiral, particularly in the near ultraviolet, and allow us to better differentiate compact star clusters from individual stars and to measure the luminosities of even faint clusters in the U band. We find that the luminosity function for clusters outside of the very crowded starburst nucleus can be approximated by a power law, dN/dL \\propto L^{alpha}, with alpha = -2.04 +/- 0.08, down to M_V ~ -5.5. We test the sensitivity of the luminosity function to different selection techniques, filters, binning, and aperture correction determinations, and find that none of these contribute significantly to uncertainties in alpha. We estimate ages and masses for the clusters by comparing their measured UBVI,Halpha colors with predictions from single stellar population models....

  10. Slow aging in Secondary Organic Aerosol observed by Liquid Chromatography coupled with High-Resolution Mass Spectrometry

    Bones, D. L.; Bateman, A. P.; Nguyen, T. B.; Laskin, J.; Laskin, A.; Nizkorodov, S.


    This study investigated long term changes in the chemical composition of model biogenic secondary organic aerosol (SOA) prepared via ozonolysis of the terpene limonene. This SOA has been observed to turn brown when exposed to NH4+. Our hypothesis is that the chromophoric compounds responsible for this color change are suspected to be imidazole-like or pyridinium-like compounds. These compounds are only present in small relative amounts, hence standard mass spectrometry is insufficient to unambiguously detect these compounds. However, a combination of HPLC and high resolution electrospray ionization mass spectrometry allows assignments of chemical formulae to individual peaks. These and other experiments confirm the presence of N-containing compounds in treated SOA. We are in the process of determining the exact identity of these species by MS/MS methods. LC-MS can also provide information about the polarity of the compounds in SOA. Most compounds in limonene-O3 SOA are polar and are detected at short retention times; peaks suggesting trimeric species appear at longer retention times in the case of fresh SOA, but at shorter times with the bulk of the components for aged SOA. Limonene SOA has been shown to be composed of monomers, dimers, trimers and larger oligomers. The appearance of trimers in specific regions of the chromatogram suggests these species are genuine SOA components and not an artifact of electrospray ionization. Changes in biogenic SOA over time are important because of the propensity of SOA to affect direct and indirect radiative forcing.

  11. Age dependency of central and peripheral systolic blood pressures: Cross-sectional and longitudinal observations in European populations

    Wojciechowska, Wiktoria; Stolarz-Skrzypek, Katarzyna; Tikhonoff, Valérie; Richart, Tom; Seidlerová, Jitka; Cwynar, Marcin; Thijs, Lutgarde; Li, Yan; Kuznetsova, Tatiana; Filipovský, Jan; Casiglia, Edoardo; Grodzicki, Tomasz; Kawecka-Jaszcz, Kalina; O'Rourke, Michael; Staessen, Jan A.


    Abstract Background. As arteries become stiffer with ageing, reflected waves move faster and augment late systolic pressure. We investigated the age dependency of peripheral and central systolic pressure, pressure amplification (peripheral systolic blood pressure - central systolic blood pressure), and peripheral and central systolic augmentation (maximal systolic pressure minus the first peak of the pressure wave). Methods. We randomly recruited 1420 White Europeans (mean age, 41.7 years). p...

  12. Observational study of the effects of age, diabetes mellitus, cirrhosis and chronic kidney disease on sublingual microvascular flow

    Reynolds, Toby; Vivian-Smith, Amanda; Jhanji, Shaman; Pearse, Rupert M.


    Background Sidestream dark field (SDF) imaging has been used to demonstrate microcirculatory abnormalities in a variety of critical illnesses. The microcirculation is also affected by advancing age and chronic comorbidities. However, the effect of these conditions on SDF microcirculatory parameters has not been well described. Methods SDF images were obtained from five groups of 20 participants: healthy volunteers under the age of 25, healthy volunteers over the age of 55, and clinic patients...

  13. Trends in Outcomes for Out-of-Hospital Cardiac Arrest by Age in Japan: An Observational Study.

    Fukuda, Tatsuma; Ohashi-Fukuda, Naoko; Matsubara, Takehiro; Doi, Kent; Kitsuta, Yoichi; Nakajima, Susumu; Yahagi, Naoki


    Population aging has rapidly advanced throughout the world and the elderly accounting for out-of-hospital cardiac arrest (OHCA) has increased yearly.We identified all adults who experienced an out-of-hospital cardiac arrest in the All-Japan Utstein Registry of the Fire and Disaster Management Agency, a prospective, population-based clinical registry, between 2005 and 2010. Using multivariable regression, we examined temporal trends in outcomes for OHCA patients by age, as well as the influence of advanced age on outcomes. The primary outcome was a favorable neurological outcome at 1 month after OHCA.Among 605,505 patients, 454,755 (75.1%) were the elderly (≥65 years), and 154,785 (25.6%) were the oldest old (≥85 years). Although neurological outcomes were worse as the age group was older (P < 0.0001 for trend), there was a significant trend toward improved neurological outcomes during the study period by any age group (P < 0.005 for trend). After adjustment for temporal trends in various confounding variables, neurological outcomes improved yearly in all age groups (18-64 years: adjusted OR per year 1.15 [95% CI 1.13-1.18]; 65-84 years: adjusted OR per year 1.12 [95% CI 1.10-1.15]; and ≥85 years: adjusted OR per year 1.08 [95% CI 1.04-1.13]). Similar trends were found in the secondary outcomes.Although neurological outcomes from OHCA ware worse as the age group was older, the rates of favorable neurological outcomes have substantially improved since 2005 even in the elderly, including the oldest old. Careful consideration may be necessary in limiting treatment on OHCA solely for the reason of advanced age. PMID:26656330

  14. Photochemical age of air pollutants, ozone, and secondary organic aerosol in transboundary air observed on Fukue Island, Nagasaki, Japan

    Irei, Satoshi; Takami, Akinori; Sadanaga, Yasuhiro; Nozoe, Susumu; Yonemura, Seiichiro; Bandow, Hiroshi; Yokouchi, Yoko


    To better understand the secondary air pollution in transboundary air over westernmost Japan, ground-based field measurements of the chemical composition of fine particulate matter ( ≤ 1 µm), mixing ratios of trace gas species (CO, O3, NOx, NOy, i-pentane, toluene, and ethyne), and meteorological elements were conducted with a suite of instrumentation. The CO mixing ratio dependence on wind direction showed that there was no significant influence from primary emission sources near the monitoring site, indicating long- and/or mid-range transport of the measured chemical species. Despite the considerably different atmospheric lifetimes of NOy and CO, these mixing ratios were correlated (r2 = 0.67). The photochemical age of the pollutants, t[OH] (the reaction time × the mean concentration of OH radical during the atmospheric transport), was calculated from both the NOx / NOy concentration ratio (NOx / NOy clock) and the toluene / ethyne concentration ratio (hydrocarbon clock). It was found that the toluene / ethyne concentration ratio was significantly influenced by dilution with background air containing 0.16 ppbv of ethyne, causing significant bias in the estimation of t[OH]. In contrast, the influence of the reaction of NOx with O3, a potentially biasing reaction channel on [NOx] / [NOy], was small. The t[OH] values obtained with the NOx / NOy clock ranged from 2.9 × 105 to 1.3 × 108 h molecule cm-3 and were compared with the fractional contribution of the m/z 44 signal to the total signal in the organic aerosol mass spectra (f44, a quantitative oxidation indicator of carboxylic acids) and O3 mixing ratio. The comparison of t[OH] with f44 showed evidence for a systematic increase of f44 as t[OH] increased, an indication of secondary organic aerosol (SOA) formation. To a first approximation, the f44 increase rate was (1.05 ± 0.03) × 10-9 × [OH] h-1, which is comparable to the background-corrected increase rate observed during the New England Air Quality

  15. Microphysics-based black carbon aging in a global CTM: constraints from HIPPO observations and implications for global black carbon budget

    He, Cenlin; Li, Qinbin; Liou, Kuo-Nan; Qi, Ling; Tao, Shu; Schwarz, Joshua P.


    We develop and examine a microphysics-based black carbon (BC) aerosol aging scheme that accounts for condensation, coagulation, and heterogeneous chemical oxidation processes in a global 3-D chemical transport model (GEOS-Chem) by interpreting the BC measurements from the HIAPER Pole-to-Pole Observations (HIPPO, 2009-2011) using the model. We convert aerosol mass in the model to number concentration by assuming lognormal aerosol size distributions and compute the microphysical BC aging rate (excluding chemical oxidation aging) explicitly from the condensation of soluble materials onto hydrophobic BC and the coagulation between hydrophobic BC and preexisting soluble particles. The chemical oxidation aging is tested in the sensitivity simulation. The microphysical aging rate is ˜ 4 times higher in the lower troposphere over source regions than that from a fixed aging scheme with an e-folding time of 1.2 days. The higher aging rate reflects the large emissions of sulfate-nitrate and secondary organic aerosol precursors hence faster BC aging through condensation and coagulation. In contrast, the microphysical aging is more than 5-fold slower than the fixed aging in remote regions, where condensation and coagulation are weak. Globally, BC microphysical aging is dominated by condensation, while coagulation contribution is largest over eastern China, India, and central Africa. The fixed aging scheme results in an overestimate of HIPPO BC throughout the troposphere by a factor of 6 on average. The microphysical scheme reduces this discrepancy by a factor of ˜ 3, particularly in the middle and upper troposphere. It also leads to a 3-fold reduction in model bias in the latitudinal BC column burden averaged along the HIPPO flight tracks, with largest improvements in the tropics. The resulting global annual mean BC lifetime is 4.2 days and BC burden is 0.25 mg m-2, with 7.3 % of the burden at high altitudes (above 5 km). Wet scavenging accounts for 80.3 % of global BC

  16. Observation of granulations in the basal body of ovarioles and follicular dilatations for the determination of physiological age ofAnopheles gambiaes.s.

    Rodrigue Anagonou; Virgile Gnanguenon; Fiacre Agossa; Bruno Akinro; Armand Akpo; Martial Gbegbo; Albert Salako; Martin Akogbto


    Objective:To explore ovariole basal body granulations and follicular dilatations for determining physiological age inAnopheles gambiaes.s.(An. gambiaes.s.). Methods: Mosquitoes were collected by using window trap catch and identified morphologically. For the first lot ofmosquitoes, they were dissected, and ovary was left in distilled water for reading ovarian tracheoles and the second was cut and transferred to another blade in a physiological liquid for verification of ovariole basal body granulations. The same approach was followed with the second lot of mosquitoes where follicular dilatations were found after classic dilaceration of ovaries were transferred into physiological liquid. The other body parts of mosquitoes were used to identify the species of theAn. gambiaes.s. complex by PCR. Results:Among the 123An. gambiae s.s. of the first lot, the method of Detinova determined the age of 89 mosquitoes versus 114 for the observation of granulations (P > 0.05). Among the 112An. gambiae s.s. of the second lot, the method of Detinova determined the age of 84 mosquitoes versus 93 for the observation of follicular dilatations (P > 0.05). Unlike the method of Detinova, observation of follicular dilatations and basal body granulations of ovarioles were possible beyond the stage II Christophers. Conclusions: Overall, the observation of follicular dilatations and ovariole basal body granulations are reliable for the determination of the physiological age inAn. gambiaes.s. Furthermore, these two methods can be used beyond the stage II.

  17. Observable Indicators of Flow Experience: A Developmental Perspective on Musical Engagement in Young Children from Infancy to School Age

    Custodero, Lori A.


    Flow experience is an optimal state determined by an individual's perception of high skill and high challenge for a given task. In this study, young children's flow experience is examined in four naturally occurring music learning environments: infants and two-year-olds in childcare settings, and school-age children in Suzuki violin and Dalcroze…

  18. Differences in Oral Sexual Behaviors by Gender, Age, and Race Explain Observed Differences in Prevalence of Oral Human Papillomavirus Infection

    Gypsyamber D'Souza; Kevin Cullen; Janice Bowie; Roland Thorpe; Carole Fakhry


    PURPOSE: This study explores whether gender, age and race differences in oral sexual behavior account for the demographic distribution of oral human papillomavirus infection (HPV) and HPV-positive oropharyngeal cancer (HPV-OSCC). METHODS: This analysis included 2,116 men and 2,140 women from NHANES (2009-10) who answered a behavioral questionnaire and provided an oral-rinse sample for HPV detection. Weighted prevalence estimates and prevalence ratios (PR) were calculated for sexual behaviors ...

  19. Hydrological evidence for a North Atlantic oscillation during the Little Ice Age outside its range observed since 1850

    Martín-Puertas, C.; Dorado-Liñán, I.; A. Brauer; E. Zorita; B. L. Valero-Garcés; Gutierrez, E.


    An annual-resolved precipitation reconstruction for the last 800 yr in Southern Spain has been performed using stable carbon isotope (δ13C) of Pinus nigra tree rings. The reconstruction exhibits high- to low-frequency variability and distinguishes a Little Ice Age (LIA, AD 1350–1850) characterized by lower averaged rainfall than both in the transition from the Medieval Climate Anomaly to the LIA and in the 20th century. The ...

  20. Intra- and inter-observer reproducibility study of gestational age estimation using three common foetal biometric parameters: Experienced versus inexperienced sonographer

    Aim: To assess reproducibility of estimating gestational age (GA) of foetus using femur length (FL), biparietal diameter (BPD) and abdominal circumference (AC) within experienced and inexperienced sonographers and between the two. Patients and methods: Two sets of GA estimates each were obtained for FL, BPD and AC by the two observers in 20 normal singleton foetuses. The first estimates for the three biometric parameters were made by the experienced sonographer. Subsequently, the inexperienced sonographer, blind to the estimates of the first observer obtained his own estimates for the same biometric parameters. After a time interval of ten minutes the process was repeated for the second set of GA estimates. All the gestational age estimates were made following standard protocol. Statistical analysis was performed by Pearson's and intraclass correlations, coefficient of variation and Bland–Altman plots. Statistical inferences were drawn at p < 0.05. Results: The Pearson's and intraclass correlations of between GA estimates within and between both observers from measurement of FL, BPD and AC were very high and statistically significant (p < 0.05). Coefficient of variation for duplicate measurements for GA estimates within observers and between observers were quite negligible. Between observers, the first and second GA estimates from FL measurements showed the least variation. Estimates from BPD and AC measurements showed greater degree of variation between the observers. Conclusion: Reproducibility of GA estimation using FL, BPD and AC within experienced and inexperienced sonographers and between the two was excellent. Therefore, a fresh Nigerian radiography graduate with adequate exposure in obstetric ultrasound can correctly determine the gestational age of foetus in routine obstetric ultrasound without supervision

  1. Star Cluster Mass and Age Distributions of Two Fields in M83 Based on HST/WFC3 Observations

    Chandar, Rupali; Calzetti, Daniela; O'Connell, Robert


    We study star clusters in two fields in the nearby spiral galaxy M83 using broad and narrow band optical imaging taken with the WFC3 on-board HST. We present results based on several different catalogs of star clusters in an inner and outer field, and conclude that different methods of selection do not strongly impact the results, particularly for clusters older than $\\approx$10 Myr. The age distributions can be described by a power law, $dN/d\\tau \\propto\\tau^{\\gamma}$, with $\\gamma\\approx -$0.84$\\pm$0.12 in the inner field, and $\\gamma\\approx -$0.48$\\pm$0.12 in the outer field for $\\tau\\gtrsim$10 Myr. We bracket the difference, $\\Delta \\gamma$, between the two fields to be in the range 0.18$-$0.36, based on estimates of the relative star formation histories. The mass functions can also be described by a power law, $dN/dM\\propto M^{\\beta}$, with $\\beta\\approx -$1.98$\\pm$0.14 and $\\beta\\approx $2.34$\\pm$0.26 in the inner and outer fields, respectively. We conclude that the shapes of the mass and age distributi...

  2. Ejecta detection in the middle-aged Galactic supernova remnant G296.1-0.5 observed with Suzaku

    Gok, F


    In this paper, we report the detection of ejecta in the middle-aged Galactic supernova remnant G296.1-0.5 with the X-ray Imaging Spectrometer onboard the Suzaku satellite. The spectra of three lobes, north, southeast and southwest and inter-lobe regions, consist of soft (0.3-2.0 keV) emission originated from non-equilibrium ionization plasma. In north, southeast and inter-lobe regions, the thermal emission can be represented by a one-component, in southwest region it can be represented by two- component non-equilibrium ionization (VNEI) model. The spectra of studied regions have lines of N, O, Ne, Mg and Si elements. Si emission from this remnant is shown for the first time in this work. Enhanced abundances of Ne, Mg and Si elements obtained show the ejecta contribution in all regions. Assuming that the remnant is in Sedov phase, we obtained ambient density n0 ~ 0.45 cm-3, age t ~ 2.8 x 104 yr, shock velocity Vs ~ 320 km s-1, shock temperature Ts ~ 1.2 x 106 K, and swept-up mass Msw ~ 340 M at an adopted dist...

  3. Observation of granulations in the basal body of ovarioles and follicular dilatations for the determination of physiological age of Anopheles gambiae s.s.

    Rodrigue Anagonou


    Full Text Available Objective: To explore ovariole basal body granulations and follicular dilatations for determining physiological age in Anopheles gambiae s.s. (An. gambiae s.s.. Methods: Mosquitoes were collected by using window trap catch and identified morphologically. For the first lot of mosquitoes, they were dissected, and ovary was left in distilled water for reading ovarian tracheoles and the second was cut and transferred to another blade in a physiological liquid for verification of ovariole basal body granulations. The same approach was followed with the second lot of mosquitoes where follicular dilatations were found after classic dilaceration of ovaries were transferred into physiological liquid. The other body parts of mosquitoes were used to identify the species of the An. gambiae s.s. complex by PCR. Results: Among the 123 An. gambiae s.s. of the first lot, the method of Detinova determined the age of 89 mosquitoes versus 114 for the observation of granulations (P > 0.05. Among the 112 An. gambiae s.s. of the second lot, the method of Detinova determined the age of 84 mosquitoes versus 93 for the observation of follicular dilatations (P > 0.05. Unlike the method of Detinova, observation of follicular dilatations and basal body granulations of ovarioles were possible beyond the stage II Christophers. Conclusions: Overall, the observation of follicular dilatations and ovariole basal body granulations are reliable for the determination of the physiological age in An. gambiae s.s. Furthermore, these two methods can be used beyond the stage II.

  4. Dietary diversity, animal source food consumption and linear growth among children aged 1-5 years in Bandung, Indonesia: a longitudinal observational study.

    Muslimatun, Siti; Wiradnyani, Luh Ade Ari


    Dietary diversity involves adequate intake of macronutrient and micronutrient. The inclusion of animal source foods (ASF) in the diet helps prevent multiple nutrient deficiencies and any resultant, linear growth retardation. The objective of the current study was to assess the relationship between dietary diversity, ASF consumption and height-for-age z-score (HAZ) among children aged 12-59 months old across a 1-year observation. This longitudinal observational study without controls was conducted among four age groups: 12-23 months (n 57), 24-35 months (n 56), 36-47 months (n 58) and 48-59 months (n 56). Anthropometry and dietary intake were measured during each of four visits at 16-20-week intervals. The general characteristics and other observations were only collected at baseline and endline. During the year-long study period, approximately 27 % of the children ate a diverse diet (consumed ≥6 out of 9 food groups) according to ≥3 visits. ASF consumption was high, particularly for eggs, poultry, processed meats and liquid milk. Yet, micronutrient intake inadequacy, especially of Zn, Ca, Fe and vitamin A, was highly prevalent. A multivariate regression analysis showed that the consumption of a diverse diet and ASF was not significantly associated with the HAZ at endline, after controlling for demographic characteristics and the baseline HAZ. The consumption of a diverse diet was significantly associated with Ca intake adequacy. Moreover, ASF consumption was significantly associated with adequate intake of protein and micronutrients, particularly vitamin A, Ca and Zn. Thus, the recommendation is to continue and strengthen the promotion of consuming a diverse diet that includes ASF in supporting the linear growth of young children. PMID:26817493

  5. A prospective observational study of early fetal growth velocity and its association with birth weight, gestational age at delivery, preeclampsia, and perinatal mortality

    Objectives: We aimed to measure early fetal growth velocity and to correlate this with the birth weight, gestational age at delivery, and with the incidence of adverse pregnancy outcomes specifically preeclampsia and perinatal mortality. Methods: A data based prospective observational study, wherein sonographic biometry data and specific pregnancy outcome related data were collected from pregnant women's records, starting soon after their first antenatal visit. Early fetal growth velocity was measured using BPD growth between 11 and 14 weeks scan and anomaly scan and standardizing this by Z scoring. Results: Out of 607 fetuses, 41 (6.7%) were slow growing, 531 (87.4%) normally growing, and 35 (5.7%) fast growing (Z scoring <10th, 10–90th, and >90th percentiles respectively). As fetal growth velocity increased, the mean birth weight decreased from 2958.7 ± 388.9 (<10th centile), 2742.1 ± 576.6 (10–90th centile), to 2339.3 ± 729.4 (>90th centile); and gestational age at delivery decreased from 38.5 ± 1.3 (<10th centile), 37.5 ± 2.1 (10–90th centile), to 36.4 ± 2.2 (>90th centile), and both these trends were statistically significant (p < 0.001).Faster growing fetuses had a higher risk of preterm delivery(spontaneous + indicated) compared to other 2 groups [OR 4.42 (2.18,8.98)], and slower growing fetuses had a higher risk of postdated deliveries compared to other 2 groups [OR 3.042 (1.44, 6.45)].We found no significant association between early fetal growth velocity and incidence of small for gestational age at birth/low birth weight at term, preeclampsia, and perinatal mortality. Conclusions: Early fetal growth velocity between first and second trimesters, may be one of the important factors influencing ultimate birthweight and gestational age at delivery

  6. A prospective observational study of early fetal growth velocity and its association with birth weight, gestational age at delivery, preeclampsia, and perinatal mortality

    Vasudeva, Akhila, E-mail: [Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal University, Manipal 576104, Karnataka State (India); Abraham, Anu Annie, E-mail: [Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal University, Manipal 576104, Karnataka State (India); Kamath, Asha, E-mail: [Department of Community Medicine, Kasturba Medical College, Manipal, A Constituent College of Manipal University (India)


    Objectives: We aimed to measure early fetal growth velocity and to correlate this with the birth weight, gestational age at delivery, and with the incidence of adverse pregnancy outcomes specifically preeclampsia and perinatal mortality. Methods: A data based prospective observational study, wherein sonographic biometry data and specific pregnancy outcome related data were collected from pregnant women's records, starting soon after their first antenatal visit. Early fetal growth velocity was measured using BPD growth between 11 and 14 weeks scan and anomaly scan and standardizing this by Z scoring. Results: Out of 607 fetuses, 41 (6.7%) were slow growing, 531 (87.4%) normally growing, and 35 (5.7%) fast growing (Z scoring <10th{sup ,} 10–90th, and >90th percentiles respectively). As fetal growth velocity increased, the mean birth weight decreased from 2958.7 ± 388.9 (<10th centile), 2742.1 ± 576.6 (10–90th centile), to 2339.3 ± 729.4 (>90th centile); and gestational age at delivery decreased from 38.5 ± 1.3 (<10th centile), 37.5 ± 2.1 (10–90th centile), to 36.4 ± 2.2 (>90th centile), and both these trends were statistically significant (p < 0.001).Faster growing fetuses had a higher risk of preterm delivery(spontaneous + indicated) compared to other 2 groups [OR 4.42 (2.18,8.98)], and slower growing fetuses had a higher risk of postdated deliveries compared to other 2 groups [OR 3.042 (1.44, 6.45)].We found no significant association between early fetal growth velocity and incidence of small for gestational age at birth/low birth weight at term, preeclampsia, and perinatal mortality. Conclusions: Early fetal growth velocity between first and second trimesters, may be one of the important factors influencing ultimate birthweight and gestational age at delivery.

  7. Arrival directions of large air showers, low-mu showers and old-age low-mu air showers observed at St. Chacaltaya

    Arrival directions of air showers with primary energies in the range 10 to the 16.5 power eV to 10 to the 18th power eV show the first harmonic in right ascension (RA) with amplitude of 2.7 + or - 1.0% and phase of 13-16h. However, the second harmonic in RA slightly seen for showers in the range 10 to the 18th power eV to 10 to the 19th power eV disappeared by accumulation of observed showers. The distribution of arrival directions of low-mu air showers with primary energies around 10 to the 15th power eV observed at Chacaltaya from 1962 to 1967 is referred to, relating to the above-mentioned first harmonic. Also presented in this paper are arrival directions of old-age low-mu air showers observed at Chacaltaya from 1962 to 1967, for recent interest in gamma-ray air showers

  8. Arrival directions of large air showers, low-mu showers and old-age low-mu air showers observed at St. Chacaltaya

    Hagiwara, K.; Yoshii, H.; Martinic, N.; Siles, L.; Miranda, P.; Kakimoto, F.; Obara, T.; Suga, K.; Kaneko, T.; Inoue, N.


    Arrival directions of air showers with primary energies in the range 10 to the 16.5 power eV to 10 to the 18th power eV show the first harmonic in right ascension (RA) with amplitude of 2.7 + or - 1.0% and phase of 13-16h. However, the second harmonic in RA slightly seen for showers in the range 10 to the 18th power eV to 10 to the 19th power eV disappeared by accumulation of observed showers. The distribution of arrival directions of low-mu air showers with primary energies around 10 to the 15th power eV observed at Chacaltaya from 1962 to 1967 is referred to, relating to the above-mentioned first harmonic. Also presented in this paper are arrival directions of old-age low-mu air showers observed at Chacaltaya from 1962 to 1967, for recent interest in gamma-ray air showers.

  9. Hospital Based Prospective Observational Study to Audit the Prescription Practices and Outcomes of Paediatric Patients (6 months to 5 years age group) Presenting with Acute Diarrhea

    Kondekar, Santosh; Rathi, Surbhi


    Introduction Diarrhea is a leading killer of children, accounting for 9% of all deaths among under-five children worldwide. WHO protocol deviation in management of diarrheas in children is likely due to various reasons. Aim To study the prescription practices, regarding adherence to WHO protocol and deviations, in the management of acute diarrhea in children presenting at a tertiary care hospital and its impact on the outcome. Materials and Methods This was a prospective observational hospital based study at a tertiary care carried out over a 12-month period including all cases of acute diarrhea (defined as 3 or more loose stools in last 24 hours) in children belonging to the age group of 6 months to 5 years. Patients were followed up on day 3,7,14 and 28 from the day of presentation. Software SPSS Version 17.0 was used for analysis. Correlation regression analysis was used to study predictiveness of different variables affecting outcome. Results In this study, 447 children aged between 6 months and 5 years were enrolled, of which 45 cases were lost in follow-up and excluded. The median age was 14 months. Some deviation from WHO protocol was noted in 78.4% of the cases. Most common deviations from WHO protocol were addition of probiotics (78.1% of cases) and addition of race cadotril (15.9% of cases). Inadvertent use of antibiotics in diarrhea was noted in 12.2% of cases. Presence of fever was strong predictor for use of antibiotics. Cases of early recovery within 3 days of presentation were higher in WHO protocol deviation group. Use of probiotics had statistically significant association with early recovery. Conclusion In diarrhea management, WHO protocol deviation is common. Probiotics are likely to help in early recovery. PMID:27437317

  10. Risk of Preterm or Small-for-Gestational-Age Birth After Influenza Vaccination During Pregnancy: Caveats When Conducting Retrospective Observational Studies.

    Vazquez-Benitez, Gabriela; Kharbanda, Elyse O; Naleway, Allison L; Lipkind, Heather; Sukumaran, Lakshmi; McCarthy, Natalie L; Omer, Saad B; Qian, Lei; Xu, Stanley; Jackson, Michael L; Vijayadev, Vinutha; Klein, Nicola P; Nordin, James D


    Vaccines are increasingly targeted toward women of reproductive age, and vaccines to prevent influenza and pertussis are recommended during pregnancy. Prelicensure clinical trials typically have not included pregnant women, and when they are included, trials cannot detect rare events. Thus, postmarketing vaccine safety assessments are necessary. However, analysis of observational data requires detailed assessment of potential biases. Using data from 8 Vaccine Safety Datalink sites in the United States, we analyzed the association of monovalent H1N1 influenza vaccine (MIV) during pregnancy with preterm birth (variable access to vaccines, the time-dependent nature of exposure to vaccination within pregnancy (immortal time bias), and confounding from baseline differences between vaccinated and unvaccinated women. We found a strong protective effect of vaccination on preterm birth (relative risk = 0.79, 95% confidence interval: 0.74, 0.85) when we ignored potential biases and no effect when accounted for them (relative risk = 0.91; 95% confidence interval: 0.83, 1.0). In contrast, we found no important biases in the association of MIV with small-for-gestational-age birth. Investigators conducting studies to evaluate birth outcomes after maternal vaccination should use statistical approaches to minimize potential biases. PMID:27449414

  11. The effects of methylphenidate on the classroom behavior of elementary school-age children with cerebral palsy: a preliminary observational analysis.

    Symons, Frank J; Tervo, Raymond C; Kim, Ockjean; Hoch, John


    High- and low-dose methylphenidate administration was evaluated prospectively for 3 elementary school-age children with cerebral palsy, cognitive impairments, and attention-deficit hyperactivity disorder (ADHD) symptoms using single-case, randomized, double-blind, placebo-controlled designs. An observational time sampling protocol was used to directly measure and quantify classroom behavior. Summary level analysis showed that (1) low-dose (0.3 mg/kg/dose) administration was associated with clinically significant (>50%) reductions in stereotyped and disruptive behavior relative to baseline and placebo conditions, (2) high-dose (0.5 mg/kg/dose) administration was associated with exacerbated amounts of stereotyped and disruptive behavior, and (3) no changes were directly observed for task-related behavior at either dose. Results are discussed with respect to previous research with methylphenidate administration and cerebral palsy, and the suggestion is made that further work using larger, randomly selected study samples with complementary measures of behavior and performance appears warranted. PMID:17608314


    The newly installed Wide Field Camera 3 (WFC3) on the Hubble Space Telescope has been used to obtain multi-band images of the nearby spiral galaxy M83. These new observations are the deepest and highest resolution images ever taken of a grand-design spiral, particularly in the near-ultraviolet, and allow us to better differentiate compact star clusters from individual stars and to measure the luminosities of even faint clusters in the U band. We find that the luminosity function (LF) for clusters outside of the very crowded starburst nucleus can be approximated by a power law, dN/dL ∝ L α, with α = -2.04 ± 0.08, down to MV ∼ -5.5. We test the sensitivity of the LF to different selection techniques, filters, binning, and aperture correction determinations, and find that none of these contribute significantly to uncertainties in α. We estimate ages and masses for the clusters by comparing their measured UBVI, Hα colors with predictions from single stellar population models. The age distribution of the clusters can be approximated by a power law, dN/dτ ∝ τγ, with γ = -0.9 ± 0.2, for M ∼> few x 103 M sun and τ ∼8 yr. This indicates that clusters are disrupted quickly, with ∼80%-90% disrupted each decade in age over this time. The mass function of clusters over the same M-τ range is a power law, dN/dM ∝ M β, with β = -1.94 ± 0.16, and does not have bends or show curvature at either high or low masses. Therefore, we do not find evidence for a physical upper mass limit, MC , or for the earlier disruption of lower mass clusters when compared with higher mass clusters, i.e., mass-dependent disruption. We briefly discuss these implications for the formation and disruption of the clusters.

  13. Estimation of aerosol radiative forcing over an aged-background aerosol feature during advection and non-advection events using a ground-based data obtained from a Prede Skyradiometer observation

    Ningombam, Shantikumar S.; Bagare, S. P.; Khatri, P.; Sohn, B. J.; Song, H.-J.


    Estimation of aerosol radiative forcing (ARF) was performed using a radiative transfer model (Rstar6b) along with physical and optical parameters of aerosols obtained from sky radiometer observation over Indian Astronomical Observatory (IAO), Hanle, Ladakh, during 2008-2010 from dust, anthropogenic, and aged background observing conditions. ARF was estimated at the top of the atmosphere (TOA), in the atmosphere, and at the surface during the three observing conditions. During dust and anthropogenic events, average aerosol optical depth (AOD at 500 nm) went up to 0.24 from the aged background observing condition 0.04. Such enhancement of AOD is associated by the combination of desert-dust and anthropogenic aerosols transported from distant sources as noticed from Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO). Such three types of aerosols are also identified from the observed properties of single scattering albedo (SSA), aerosol asymmetry (AS) parameter, and aerosol size distribution. The estimated ARFs at TOA, at the surface, and in atmosphere are - 3.73, - 6.82, and 3.40 Wm- 2, respectively during the dust advection period. On the contrary, the respective ARFs during the aged background observing condition are - 1.50, - 2.22, and 0.70 Wm- 2, respectively. A significant difference of spectral AOD is observed during dust, anthropogenic, and aged background observing conditions. Ångström exponent (AE) decreases from 1.05 in the aged background observing condition to 0.40 in the dust event. A significant difference of coarse-fine mode volume distribution is also observed between the dust and the anthropogenic cases. Further, the study reveals high aerosols induced during the dust and the anthropogenic episodes caused warming at atmosphere and cooling at surface which collectively may affect the local atmospheric circulation.

  14. Monthly Record Tables, December 1998, with Supplement for the 4. quarter 1998; Tableaux mensuels des mesures, Decembre 1998, avec supplement relatif au 4-eme trimestre 1998



    This report, issued under the aegis of O.P.R.I. (Office of protection against ionizing radiations), contains the activity level measurements of the radiation monitoring units throughout the country recorded in December 1998. A supplement contains the data relative to the 4. quarter is also added. Data relative toatmospheric sampling refer to surface and high altitude air as well as to atmospheric tritium concentration at Valduc. For rain water, dry fallout and deposition at soil level weekly sampling were carried out and monthly surveillance is reported. The drinking, surface and ground water measurements are reported for nuclear and non-nuclear sites. Measurement on food chains refer to cow milk, thyroids of horned cattle and fishes in the national market. Activity levels of given radioisotopes are given for vegetables and coastal sea waters as well as for waste and rain waters. Surveillance of wastes from facilities other than basic nuclear units (hospitals, research units, etc) was measured downstream to large cities in waste waters, rivers, sediments and aquatic flora. Sanitary controls on food and environment are reported as well as those carried out on workers and on operators implied in 6 nuclear incidents without consequences which occurred in December 1998 in French NPPs. The quarterly results refer to the following 16 items: 1. Radioactivity inventory in feedwater (Calvados); 2.Drinking waters; 3.Hydro-mineral sources; 4.Sea medium at Nord-Cotentin; 5.Surveillance of major National Navy facilities; 6.Surveillance of CNPE at Gravelines; 7. Surveillance of CNPE at Civaux; 8.Surveillance of COGEMA site at Marcoule; 9.Marine fauna and flora; 10.Surveillance of rice fields at Camargue; 11.Surveillance of sea sediments in Seine mouth; 12.Controlled releases; 13.Food chains; 14.Animal bones; 15.Soils; 16.Integrating dosemeters.

  15. Suzaku Observations of Thermal and Non-Thermal X-Ray Emission from the Middle-Aged Supernova Remnant G156.2+5.7

    Katsuda, Satoru; Petre, Robert; Hwang, Una; Yamaguchi, Hiroya; Mori, Koji; Tsunemi, Hiroshi


    We present results from X-ray analysis of a Galactic middle-aged supernova remnant (SNR) G156.2+5.7 which is bright and largely extended in X-ray wavelengths, showing a clear circular shape (radius approx.50'). Using the Suzaku satellite, we observed this SNR in three pointings; partially covering the northwestern (NW) rim, the eastern (E) rim, and the central portion of this SNR. In the NW rim and the central portion, we confirm that the X-ray spectra consist of soft and hard-tail emission, while in the E rim we find no significant hard-tail emission. The soft emission is well fitted by either a one-component or two-component non-equilibrium ionization (NEI) model. In the NW and E rims, a one-component (the swept-up interstellar medium) NEI model well represents the soft emission. On the other hand, in the central portion, a two-component (the interstellar medium and the metal-rich ejecta) NEI model fits the soft emission better than the one-component NEI model from a statistical point of view. The relative abundances in the ejecta component suggest that G156.2+5.7 is a remnant from a core-collapse SN explosion whose progenitor mass is less than 15 Solar Mass. The origin of the hard-tail emission detected in the NW rim and the central portion of the SNR is highly likely non-thermal synchrotron emission from relativistic electrons. In the NW rim, the relativistic electrons seems to be accelerated by a forward shock with a slow velocity of APPROX.500 km/sec.

  16. Sex, Race, and Age Differences in Observed Years of Life, Healthy Life, and Able Life among Older Adults in The Cardiovascular Health Study

    Thielke, Stephen M.; Diehr, Paula H.; Yee, Laura M.; Arnold, Alice M.; Quiñones, Ana R.; Whitson, Heather E.; Mini E. Jacob; Newman, Anne B.


    Objective: Longevity fails to account for health and functional status during aging. We sought to quantify differences in years of total life, years of healthy life, and years of able life among groups defined by age, sex, and race. Design: Primary analysis of a cohort study. Setting: 18 years of annual evaluations in four U.S. communities. Participants: 5888 men and women aged 65 and older. Measurements: Years of life were calculated as the time from enrollment to death or 18 years. Years of...

  17. Childhood IQ and all-cause mortality before and after age 65: Prospective observational study linking the Scottish Mental Survey 1932 and the Midspan studies

    Hart, C. L.; M. D. Taylor; Davey Smith, G; Whalley, L.J.; Starr, J M; Hole, D; Wilson, V.; Deary, I J


    OBJECTIVES: The objective was to investigate how childhood IQ related to all-cause mortality before and after age 65. DESIGN: The Midspan prospective cohort studies, followed-up for mortality for 25 years, were linked to individuals' childhood IQ from the Scottish Mental Survey 1932. METHODS: The Midspan studies collected data on risk factors for cardiorespiratory disease from a questionnaire and at a screening examination, and were conducted on adults in Scotland in the 1970s. An age 11 IQ f...

  18. The effect of clustering on the mobility of dislocations during aging in Nb-microalloyed strip cast steels: In situ heating TEM observations

    Cluster-strengthened Nb-microalloyed strip cast steels are of interest as clustering during aging leads to an enhancement in strength without compromising ductility, resulting in desirable mechanical properties. However, the precise strengthening mechanism is not well understood. Using in situ heating transmission electron microscopy, clustering was found to impede the movement of dislocations during aging. The attractive combination of ductility and strength was attributed to the effects of recovery and the restricted movement of dislocations through clustering

  19. Evidence-Based Novel Changes in Prevalence and Symptom Characteristics of Spleen Deficiency Syndrome in Persons of Varied Health Status and Different Ages: A Cross-Sectional Observational Study

    Yin Zhang


    Full Text Available Deficiency of the organs is a vital pathophysiologic characteristic in the elderly. A core TCM aging theory is known as aging caused by spleen deficiency syndrome (SDS that can be found in ancient and modern literature. The key objectives of this study were to establish a full-scale trial to evaluate the prevalence, symptom severity, frequency, and distribution of SDS in different age groups as related to health status (healthy, subhealthy, and chronic disease to elucidate the role of spleen deficiency in the aging process and deterioration of health status. This cross-sectional observational study was conducted in 4 hospitals in China. 1390 participants aged 20–79 were interviewed by investigators who completed questionnaires recording prevalence, severity, and frequency of symptoms as well as other relevant information. The results revealed that prevalence and symptom characteristics of SDS showed regularities with increasing age and deteriorating health status. It supports the TCM concept that spleen deficiency is an important mechanism of aging, subhealth, and chronic diseases. Early recognition of the warning signs and symptoms of SDS may lead to intervention and even prevention strategies for subhealth and chronic diseases as well as promotion of healthy aging.

  20. The Star-forming Region NGC 346 in the Small Magellanic Cloud with Hubble Space Telescope ACS Observations. II. Photometric Study of the Intermediate-Age Star Cluster BS 90

    Rochau, Boyke; Gouliermis, Dimitrios A.; Brandner, Wolfgang; Dolphin, Andrew E.; Henning, Thomas


    We present the results of our investigation of the intermediate-age star cluster BS 90, located in the vicinity of the HII region N 66 in the SMC, observed with HST/ACS. The high-resolution data provide a unique opportunity for a very detailed photometric study performed on one of the rare intermediate-age rich SMC clusters. The complete set of observations is centered on the association NGC 346 and contains almost 100,000 stars down to V ~28 mag. In this study we focus on the northern part o...

  1. Exploratory Investigation of Communication Management in Residential-Aged Care: A Comparison of Staff Knowledge, Documentation and Observed Resident-Staff Communication

    Bennett, Michelle K.; Ward, Elizabeth C.; Scarinci, Nerina A.


    Background: There is a high prevalence of communication difficulty among older people living in residential-aged care. Such functional deficits can have a negative impact on resident quality of life, staff workplace satisfaction and the provision of quality care. Systematic research investigating the nature of communication management in…


    S. Mehrabian


    Full Text Available A hundred and five strains of Salmonella havana were studied from the patients of pediatric hospital of Tehran and Tabriz during 1976-86. The sources of the strains in order to their frequency were from-stool, blood, spinal, fluid, wound and urine. From the epidemiological point of view Salmonella Havana is serotype of most non-typhoid Salmonella. All of the strains had drug resistancy and most of them were resistant to many drugs. Salmonella havana had been considered in the past as a serotype of nonpathogenic agent, but this work resulted that strain has Pathogenic strength to the children of under one year old age Symptoms of diseases caused by this strain were gastroenteritis, diarrhea, Vomiting fever, Focal infection, general infection and meningitis. This strain in about 20% of the cases, particularly in the children fewer than one year old age has caused death.

  3. Aging Skin

    ... email address Submit Home > Healthy Aging > Wellness Healthy Aging Aging skin More information on aging skin When it ... treated early. Return to top More information on Aging skin Read more from Varicose Veins ...

  4. Structural observations and U-Pb mineral ages from igneous rocks at the Archaean-Palaeoproterozoic boundary in the Salahmi Schist Belt, central Finland: constraints on tectonic evolution

    Pietikäinen, K.


    Full Text Available The study area in Vieremä, central Finland, contains part of Archaean-Palaeoproterozoic boundary. In the east, the area comprises Archaean gneiss and the Salahmi Schist Belt. The rocks of the schist belt are turbiditic metagreywackes, with well-preserved depositional structures, occurring as Proterozoic wedge-shaped blocks, and staurolite schists, the latter representing higher-strained and metamorphosed equivalents of the metagreywackes. In the west of the area there is an Archaean gneiss block, containing strongly elongated structures, and deformed Svecofennian supracrustal rocks, which are cut by deformed granitoids. These are juxtaposed with the schist belt. The boundaries of these tectonometamorphic blocks are narrow, highly strained mylonites and thrust zones. The metamorphic grade of the supracrustal rocks increases from east to west, the increase being stepwise across the mylonitic block boundaries. The rocks are more deformed from east to west with younger structures overprinting. In the staurolite schists of the Salahmi Schist Belt, the most prominent structure is a lineation (L2 that overprints the bedding and axial plane foliation. In Sorronmäki quarry, at the western boundary of the schist belt, this Palaeoproterozoic lineation dominates all the structures in tonalite gneiss, which gives a U-Pb age of 2731±6 Ma. Southeast of the quarry, at the same boundary, the Salahmi schists have been overturned towards the northeast, suggesting that the Archaean gneiss at Sorronmäki has been thrust towards the northeast over these rocks. In the western part of the study area, the Leppikangas granodiorite that intrudes the Svecofennian supracrustal rocks gives a U-Pb age of 1891+6 Ma. In the granodiorite, a strong lineation formed by the intersection of two foliations, which maybe L2 is associated with thrusting towards the northeast. The monazite age of the Archaean Sorronmäki gneiss is 1817+3 Ma, and the titanite age of the Svecofennian

  5. Is herpes zoster an additional complication in old age alongside comorbidity and multiple medications? Results of the post hoc analysis of the 12-month longitudinal prospective observational ARIZONA cohort study

    Pickering, Gisèle; Gavazzi, Gaëtan; Gaillat, Jacques; Paccalin, Marc; Bloch, Karine; Bouhassira, Didier


    Objectives To examine the burden of comorbidity, polypharmacy and herpes zoster (HZ), an infectious disease, and its main complication post-herpetic neuralgia (PHN) in young (50–70 years of age: 70−) and old (≥70 years of age: 70+) patients. Design Post hoc analysis of the results of the 12-month longitudinal prospective multicentre observational ARIZONA cohort study. Settings and participants The study took place in primary care in France from 20 November 2006 to 12 September 2008. Overall, ...

  6. Young and middle age pulsar light-curve morphology: Comparison of Fermi observations with gamma-ray and radio emission geometries

    Pierbattista, M; Gonthier, P L; Grenier, I A


    Thanks to the huge amount of gamma-ray pulsar photons collected by the Fermi Large Area Telescope since June 2008, it is now possible to constrain gamma-ray geometrical models by comparing simulated and observed light-curve morphological characteristics. We assumed vacuum-retarded dipole pulsar magnetic field and tested simulated and observed morphological light-curve characteristics in the framework of two pole emission geometries, Polar Cap (PC), radio, and Slot Gap (SG), and Outer Gap (OG)/One Pole Caustic (OPC) emission geometries. We compared simulated and observed/estimated light-curve morphological parameters as a function of observable and non-observable pulsar parameters. The PC model gives the poorest description of the LAT pulsar light-curve morphology. The OPC best explains both the observed gamma-ray peak multiplicity and shape classes. The OPC and SG models describe the observed gamma-ray peak-separation distribution for low- and high-peak separations, respectively. This suggests that the OPC ge...

  7. uvby(-$\\beta$) photometry of high-velocity and metal-poor stars X. Stars of very low metal abundance: observations, reddenings, metallicities, classifications, distances, and relative ages

    Schuster, W J; Michel, R; Nissen, P E; García, G


    uvby(--$\\beta$) photometry has been obtained for an additional 411 very metal-poor stars selected from the HK survey, and used to derive basic parameters such as interstellar reddenings, metallicities, photometric classifications, distances, and relative ages... These very metal-poor stars are compared to M92 in the c_0,(b-y)_0 diagram, and evidence is seen for field stars 1-3 Gyrs younger than this globular cluster. The significance of these younger very metal-poor stars is discussed in the context of Galactic evolution, mentioning such possibilities as hierarchical star-formation/mass-infall of very metal-poor material and/or accretion events whereby this material has been acquired from other (dwarf) galaxies with different formation and chemical-enrichment histories

  8. Ageing Studies on the Drift Tubes of the Muon Spectrometer and Observability of MSSM Heavy Higgses via a Sparticle decay Mode

    Adorisio, Cristina


    This Ph.D. thesis summarized the work performed in INFN Cosenza group within the ATLAS Muon Collaboration. This work is a representative cross section of the different aspects to the preparation of a modern day high energy physics experiment. An important part is dedicated to the testing of specialized detector elements. And the experiment's discovery potential for signatures of new theoretical proposal is evaluated. The thesis is divided into three parts. The first part, made up of the first three chapters, is an introduction about the theoretical and the experimental background of the two main work I have performed during the doctoral period. The second part, the fourth chapter, is about the main work I have dealt with, the ageing problem of the Monitored Drift Tube detectors, which make up the Muon Spectrometer. And the last third part, the fifth chapter, is about the study of an MSSM Higgs bosons decay mode into sparticles.

  9. Constraints on the Surface Magnetic Fields and Age of a Cool Hypergiant: XMM-Newton X-ray Observations of VY CMa

    Montez, R; Humphreys, R M; Turok, R L; Davidson, K


    The complex circumstellar ejecta of highly evolved, cool hypergiants are indicative of multiple, asymmetric mass loss events. To explore whether such episodic, non-isotropic mass loss may be driven by surface magnetic activity, we have observed the archetypical cool hypergiant VY CMa with the XMM-Newton X-ray satellite observatory. The hypergiant itself is not detected in these observations. From the upper limit on the X-ray flux from VY CMa at the time of our observations ($F_{X,UL}~\\approx~8\\times10^{-14} {\\rm~erg~cm}^{-2} {\\rm~s}^{-1}$, corresponding to $\\log~L_X/L_{bol}\\leq-8$), we estimate an average surface magnetic field strength $fB \\leq 2\\times10^{-3}$~G (where $f$ is the filling factor of magnetically active surface regions). These X-ray results for VY CMa represent the most stringent constraints to date on the magnetic field strength near the surface of a hypergiant. VY CMa's mass loss is episodic and may have been in a state of low surface magnetic activity during the XMM observations. The XMM obs...


    The complex circumstellar ejecta of highly evolved, cool hypergiants are indicative of multiple, asymmetric mass-loss events. To explore whether such episodic, non-isotropic mass loss may be driven by surface magnetic activity, we have observed the archetypical cool hypergiant VY CMa with the XMM-Newton X-ray satellite observatory. The hypergiant itself is not detected in these observations. From the upper limit on the X-ray flux from VY CMa at the time of our observations (F X, UL ≈ 8 × 10–14 erg cm–2 s–1, corresponding to log LX /L bol ≤ –8), we estimate an average surface magnetic field strength fB ≤ 2 × 10–3 G (where f is the filling factor of magnetically active surface regions). These X-ray results for VY CMa represent the most stringent constraints to date on the magnetic field strength near the surface of a hypergiant. VY CMa's mass loss is episodic, however, and the hypergiant may have been in a state of low surface magnetic activity during the XMM observations. The XMM observations also yield detections of more than 100 X-ray sources within ∼15' of VY CMa, roughly 50 of which have near-infrared counterparts. Analysis of X-ray hardness ratios and IR colors indicates that some of these field sources may be young, late-type stars associated with VY CMa, its adjacent molecular cloud complex, and the young cluster NGC 2362. Further study of the VY CMa field is warranted, given the potential to ascertain the evolutionary timescale of this enigmatic, massive star

  11. Objective method to determine the contribution of the great toe to standing balance and preliminary observations of age-related effects.

    Tanaka, T; Noriyasu, S; Ino, S; Ifukube, T; Nakata, M


    The purpose of this study was to examine the relationship between toe pressure and tactile sensitivity in the great toe and to describe two newly developed measurements of postural stability. The subjects of the study were 21 healthy volunteers. The subjects were divided into two age groups, the young group (mean 21.0 +/- 1.6 years, 7 males and 6 females), and the elderly group (mean 71.4 +/- 2.8 years, 4 males and 4 females). The methods and materials used for the first experiment (balance test): The instrument for measuring standing balance was a force plate. Data were analyzed to provide two main variables: 1) body sway index (SI: mm) and 2) toe pressure (%BW/cm2). The subjects were asked to stand in a relaxed posture for 20 s. The variables of body sway were measured in four conditions: normal surface with eyes open or closed, and soft surface with eyes open or closed. Second experiment (tactile sense test): This experiment utilized a new system which was developed for measuring the tactile sensation. The tactile threshold value was measured with the subject seated in a chair, the back supported, and the hips and knees flexed at 90 degrees. The contactor pulled and pushed the toe longitudinally along its axis at a constant velocity of 1 mm/s. There were significant differences between the young and elderly groups in the tactile sense of the great toe (p < .001). No significant difference between age groups was found for postural sway while the subjects stood on the normal surface with eyes open; however, when they stood on the soft surface with their eyes open and closed, the elderly showed significantly more sway (p < 0.01) than the young. Moreover, the maximal great toe pressure in the elderly group was significantly greater than that in the young group. The results suggest that the reduced tactile sense, deprivation of visual information, and toe pressure weakness are all important factors associated with postural instability. PMID:8798075

  12. Age at Menarche, Level of Education, Parity and the Risk of Hysterectomy: A Systematic Review and Meta-Analyses of Population-Based Observational Studies.

    Louise F Wilson

    Full Text Available Although rates have declined, hysterectomy is still a frequent gynaecological procedure. To date, there has been no systematic quantification of the relationships between early/mid-life exposures and hysterectomy. We performed a systematic review and meta-analyses to quantify the associations between age at menarche, education level, parity and hysterectomy.Eligible studies were identified by searches in PubMed and Embase through March 2015. Study-specific estimates were summarised using random effects meta-analysis. Heterogeneity was explored using sub-group analysis and meta-regression.Thirty-two study populations were identified for inclusion in at least one meta-analysis. Each year older at menarche was associated with lower risk of hysterectomy-summary hazard ratio 0.86 (95% confidence interval: 0.78, 0.95; I2 = 0%; summary odds ratio 0.88 (95% confidence interval: 0.82, 0.94; I2 = 61%. Low education levels conferred a higher risk of hysterectomy in the lowest versus highest level meta-analysis (summary hazard ratio 1.87 (95% confidence interval: 1.25, 2.80; I2 = 86%, summary odds ratio 1.51 (95% confidence interval: 1.35, 1.69; I2 = 90% and dose-response meta-analysis (summary odds ratio 1.17 (95% confidence interval: 1.12, 1.23; I2 = 85% per each level lower of education. Sub-group analysis showed that the birth cohort category of study participants, the reference category used for level of education, the year the included article was published, quality of the study (as assessed by the authors and control for the key variables accounted for the high heterogeneity between studies in the education level meta-analyses. In the meta-analyses of studies of parity and hysterectomy the results were not statistically significant.The present meta-analyses suggest that the early life factors of age at menarche and lower education level are associated with hysterectomy, although this evidence should be interpreted with some caution due to variance

  13. The Effect of Exclusive Breastfeeding on Hospital Stay and Morbidity due to Various Diseases in Infants under 6 Months of Age: A Prospective Observational Study

    Kaur, Amarpreet; Singh, Karnail; Pannu, M. S.; Singh, Palwinder; Sehgal, Neeraj; Kaur, Rupinderjeet


    Background. Mother's milk is the best for the babies. Protective and preventive role of breast milk was evaluated in this study by assessing the relation of type of feeding and duration of hospital stay or morbidity. Methods. This prospective study was conducted in a tertiary care hospital and 232 infants in the age group of 14 weeks to 6 months formed the sample. There are two groups of infants, that is, one for breastfed and one for top fed infants. Statistical analysis was done and results were calculated up to 95% to 99% level of significance to find effect of feeding pattern on hospital stay due to various diseases and morbidity. Results. Prolonged hospital stay, that is, >7 days, was lesser in breastfed infants and results were statistically significant in case of gastroenteritis (p value < 0.001), bronchopneumonia (p value = 0.0012), bronchiolitis (p value = 0.005), otitis media (p value = 0.003), and skin diseases (p value = 0.047). Lesser morbidity was seen in breastfed infants with gastroenteritis (p value 0.0414), bronchopneumonia (p value 0.03705), bronchiolitis (p value 0.036706), meningitis (p value 0.043), and septicemia (p value 0.04). Conclusions. Breastfed infants have shorter hospital stay and lesser morbidity in regard to various diseases as compared to top fed infants.

  14. The Star-forming Region NGC 346 in the Small Magellanic Cloud with Hubble Space Telescope ACS Observations. II. Photometric Study of the Intermediate-Age Star Cluster BS 90

    Rochau, Boyke; Brandner, Wolfgang; Dolphin, Andrew E; Henning, Thomas


    We present the results of our investigation of the intermediate-age star cluster BS 90, located in the vicinity of the HII region N 66 in the SMC, observed with HST/ACS. The high-resolution data provide a unique opportunity for a very detailed photometric study performed on one of the rare intermediate-age rich SMC clusters. The complete set of observations is centered on the association NGC 346 and contains almost 100,000 stars down to V ~28 mag. In this study we focus on the northern part of the region, which covers almost the whole stellar content of BS 90. We construct its stellar surface density profile and derive structural parameters. Isochrone fits on the CMD of the cluster results in an age of about 4.5 Gyr. The luminosity function is constructed and the present-day mass function of BS 90 has been obtained using the mass-luminosity relation, derived from the isochrone models. We found a slope between -1.30 and -0.95, comparable or somewhat shallower than a typical Salpeter IMF. Examination of the rad...

  15. Observing participating observation

    Keiding, Tina Bering


    Current methodology concerning participating observation in general leaves the act of observation unobserved. Approaching participating observation from systems theory offers fundamental new insights into the topic. Observation is always participation. There is no way to escape becoming a partici......Current methodology concerning participating observation in general leaves the act of observation unobserved. Approaching participating observation from systems theory offers fundamental new insights into the topic. Observation is always participation. There is no way to escape becoming...... as the idea of the naïve observer becomes a void. Not recognizing and observing oneself as observer and co-producer of empirical data simply leaves the process of observation as the major unobserved absorber of contingency in data production based on participating observation....

  16. Observing participating observation

    Keiding, Tina Bering


    Current methodology concerning participating observation in general leaves the act of observation unobserved. Approaching participating observation from systems theory offers fundamental new insights into the topic. Observation is always participation. There is no way to escape becoming a partici......Current methodology concerning participating observation in general leaves the act of observation unobserved. Approaching participating observation from systems theory offers fundamental new insights into the topic. Observation is always participation. There is no way to escape becoming...... as the idea of the naïve observer becomes a void. Not recognizing and observing oneself as observer and co-producer of empirical data simply leaves the process of observation as the major unobserved absorber of contingency in data production based on participating observation....

  17. Hyperextension in the pre-Caledonian margin of Baltica: new observations and U-Pb ages from the Samnanger Complex, Major Bergen Arc, western Norway.

    Jakob, Johannes; Alsaif, Manar; Andersen, Torgeir; Corfu, Fernando


    The Samnanger Complex (SC) of the Major Bergen Arc in western Norway (Færseth et al., 1977) comprises a thick succession of original fine-grained marine sediments, now mica- and graphitic schists, some fine-grained impure marbles as well as local quartzite, meta-sandstones and meta-fanglomerates of continental affinity. There are also minor meta-igneous rocks including amphibolite, metagabbro as well as felsic and mafic gneisses. The most characteristic rocks in this heterogeneous unit, however, are numerous solitary mantle-peridotites now present as variably altered serpentinites and soapstones with commonly developed ophicarbonate alteration. Detrital serpentinite and soapstone deposits have also been identified in one locality, now mostly removed by quarrying for building and ornamental stones. The SC is continuous with a regional mélange unit, which can be traced across southern Norway towards Røros (Andersen et al., 2012). The mélange is structurally positioned below large crystalline nappes such as the Jotun Nappe and the SC is structurally positioned in-between the underlying Lower Bergsdalen and the overlying Lindås nappes (Færseth et al., 1977). The lithological association of the mélange with its common presence of solitary and detrital meta-peridotites suggests that it was formed by hyperextension in a magma poor margin. After early-Caledonian metamorphism and deformation associated with emplacement of gabbro and granitoids in the early Ordovician it was finally emplaced in the Caledonian nappe stack after the closure of the Iapetus Ocean. Late granitoid dikes cutting most of the deformation fabric are ~420 Ma. New ID-TIMS U-Pb ages of a pegmatitic meta-gabbro (~486 Ma) and a mylonitic granitoid (~476 Ma) indicate magma emplacement, probably related to subduction within distal parts of the hyperextended margin. We suggest that the exhumation and hydration of subcontinental lithospheric mantle in hyperextended basins may lead to a long

  18. Age and structure parameters of a remote M31 globular cluster B514 based on HST, 2MASS, GALEX and BATC observations

    Ma, Jun; Wu, Zhenyu; Fan, Zhou; Zhang, Tianmeng; Wu, Jianghua


    B514 is a remote M31 globular cluster which locating at a projected distance of R_p~55 kpc. Deep observations with the Advanced Camera for Surveys (ACS) on the Hubble Space Telescope (HST) are used to provide the accurate integrated light and star counts of B514. By coupling analysis of the distribution of the integrated light with star counts, we are able to reliably follow the profile of the cluster out to ~40". Based on the combined profile, we study in detail its surface brightness distribution in F606W and F814W filters, and determine its structural parameters by fitting a single-mass isotropic King model. The results showed that, the surface brightness distribution departs from the best-fit King model for r>10". B514 is quite flatted in the inner region, and has a larger half-light radius than majority of normal globular clusters of the same luminosity. It is interesting that, in the M_V versus log R_h plane, B514 lies nearly on the threshold for ordinary globular clusters as defined by Mackey & van...

  19. A型肉毒毒素联合透明质酸注射治疗面部老化临床疗效观察%Botulinum toxin A joint hyaluronic acid injection Facial aging treatment clinical curative effect observation

    王芳芳; 张东晓; 熊玮; 王艳; 徐丽红


    Objective:To observe the clinical effect and safety of botulinum toxin type A and Hyaluronic Acid injection appliedin the treatmernt of facial skin aging.Methods:45 patients of different skin aging problem, according to botulinum toxin type A,and hyaluronic acid injection therapy. All patients were followed up and observed treatment effect and prognosis.Results:45 patients with skin aging problem has been improved to varying degrees of, treatment effective rate was 83.11%. Postoperative adverse reactions and are temporary, recovering well.Conclusion:Combined botulinum toxin A and hyaluronic acid injection treatment of facial skin aging good curative effect, patient satisfaction is high, safe and effective.%目的:探讨A型肉毒毒素、透明质酸注射联合治疗面部皮肤老化疗效及安全性。方法:对45例患者面部老化问题,采用A型肉毒毒素联合透明质酸注射治疗,观察治疗效果。结果:患者面部老化问题得到不同程度的改善,治疗有效率83.11%,术后不良反应轻且都是暂时性,恢复良好。结论:A型肉毒毒素联合透明质酸注射治疗面部皮肤老化疗效好,患者满意度高,安全有效。

  20. Rural Aging

    ... Rural Health > Topics & States > Topics View more Rural Aging The nation's population is aging, and with that change comes increased healthcare needs. ... Disease Control and Prevention report, The State of Aging and Health in America 2013 , the population 65 ...

  1. AgeFactDB—the JenAge Ageing Factor Database—towards data integration in ageing research

    Hühne, Rolf; Thalheim, Torsten; Sühnel, Jürgen


    AgeFactDB ( is a database aimed at the collection and integration of ageing phenotype data including lifespan information. Ageing factors are considered to be genes, chemical compounds or other factors such as dietary restriction, whose action results in a changed lifespan or another ageing phenotype. Any information related to the effects of ageing factors is called an observation and is presented on observation pages. To provide concise access to the complete info...

  2. Age -- Metallicity relation in the MCs clusters (Based on observations made with the Danish 1.54 m and ESO 3.6m Telescopes at La Silla Observatory, Chile)

    Livanou, E; Kontizas, M; Nordström, B; Kontizas, E; Andersen, J; Dirsch, B; Karampelas, A


    Aims: To investigate a possible dependence between age and metallicity in the Magellanic Clouds (MCs) from a study of small open star clusters, using Str\\"{o}mgren photometry. Our goal is to trace evidence of an age metallicity relation (AMR) and correlate it with the mutual interactions of the two MCs. Our aim is also to correlate the AMR with the spatial distribution of the clusters. In the Large Magellanic Cloud (LMC), the majority of the selected clusters are young (up to 1 Gyr) and our aim is to search for an AMR at this epoch which has not been much studied. Methods: We report on results for 15 LMC and 8 Small Magellanic Cloud (SMC) clusters, scattered all over the area of these galaxies, to cover a wide spatial distribution and metallicity range. The selected LMC clusters were observed with the 1.54m Danish Telescope in Chile, using the Danish Faint Object Spectrograph and Camera (DFOSC) with a single 2kx2k CCD, whereas the SMC clusters were observed with the ESO 3.6m Telescope also in Chile with the E...

  3. Comparison of response to 2-years’ growth hormone treatment in children with isolated growth hormone deficiency, born small for gestational age, idiopathic short stature, or multiple pituitary hormone deficiency: combined results from two large observational studies

    Lee Peter A


    Full Text Available Abstract Background Few studies have compared the response to growth hormone (GH treatment between indications such as isolated growth hormone deficiency (IGHD, born small for gestational age (SGA, idiopathic short stature (ISS, and multiple pituitary hormone deficiency (MPHD. The aim of this analysis of data, collected from two large ongoing observational outcome studies, was to evaluate growth and insulin-like growth factor-I (IGF-I response data for children of short stature with IGHD, MPHD, SGA, or ISS following two years of treatment with the recombinant GH product Norditropin® (Novo Nordisk A/S, Bagsværd, Denmark. Methods Analysis of auxologic data from two ongoing prospective observational studies, NordiNet® International Outcomes Study (NordiNet® IOS and NovoNet®/American Norditropin® Studies: Web-enabled Research (ANSWER Program®. Results 4,582 children aged p = 0.047; p  0.001 vs. IGHD, respectively. Height gain was comparable between IGHD and MPHD. In pre-pubertal children vs. total population, height SDS change after two years was: IGHD, +1.24 vs. +0.97; SGA, +1.17 vs. +1.03; ISS, +1.04 vs. +0.84; and MPHD, +1.16 vs. +0.99 (all p  Conclusions After two years’ GH treatment, change in height SDS was greater in SGA and less in ISS, compared with IGHD; the discrepancy in responses may be due to the disease nature or confounders (i.e. age. Height SDS increase was greatest in pre-pubertal children, supporting early treatment initiation to optimize growth outcomes.

  4. Arterial Ageing

    Lee, Seung-Jun; Park, Sung-Ha


    Arterial ageing is characterized by age associated degeneration and sclerosis of the media layer of the large arteries. However, besides ageing, clinical conditions, which enhance oxidative stress and inflammation act to accelerate the degree of arterial ageing. In this review, we summarized the pathophysiology and contributing factors that accelerate arterial ageing. Among them, we focused on hypertension, the renin-angiotensin-aldosterone system and vascular inflammation which are modifiabl...

  5. 舒适护理在高龄梗阻性黄疸患者中的效果观察%Comfortable nursing in advanced age obstruction jaundice patlents effect observation

    金宁雀; 申莹


    Goal: Discussion introduction comfortable nursing and responsibility system nursing in advanced age obstruction jaundice patient's effect.Method:Review liver disease branch obstruction jaundice patient material.Will implement the responsibility system nursing advanced age obstruction jaundice patient 80 examples to take the control group, will introduce the comfortable nursing pattern the advanced age obstruction jaundice patient 80 examples to take the observation group, to nurses the work degree of satisfaction and the healthy knowledge knowing rate difference compared with two group of patients.Finally: The comfortable nurse service in the advanced age obstruction jaundice patient nurses, the fanily member and the patient to nurses the work degree of satisfaction and healthy knowledge knowing rate nurses the hospital ward distinct enhancement compared to the conventional whole.Conclusion: Comfortable nursing in the advanced age obstruction jaundice patient nurses can enhance the degree of satisfaction obviously, reduces the complication the occurrence, reduces the patient to be hospitalized the time, was the construction harmonious protects the trouble relations to provide the safeguard.%目的:探讨引进舒适护理与责任制护理在高龄梗阻性黄疸患者中的效果.方法:回顾性的肝病科梗阻性黄疸病员资料.将实施责任制护理高龄梗阻性黄疸患者80例作为对照组,将引进舒适护理模式的高龄梗阻性黄疸患者80例作为观察组,比较二组患者对护理工作满意度与健康知识知晓率的差异.结果:舒适护理服务在高龄梗阻性黄疸患者护理中,家属与患者对护理工作满意度与健康知识知晓率比常规整体护理病房明显提高.结论:舒适护理在高龄梗阻性黄疸患者护理中能明显提高满意度,减少并发症的发生,缩短患者住院时间,为构建和谐的护患关系提供了保障.

  6. Active ageing technologies

    Lassen, Aske Juul

    physical and productive activity; e.g. that a game of billiards is a technology of active aging. Thus, active aging is enacted in the socio-material practices of the technologies in this paper. The paper contributes with a strengthening of the concept of active aging, by focusing on entangled practices and...... elderly. As part of this rearticulation of old age, many new technologies take form. This paper uses a wide concept of technologies (devices, regimes, strategies and ways of doing) and argues that technologies form active aging subjectivities, and on the other hand, that these subjectivities in their...... socio-material practices form active aging. Hence, active aging is a mutual entanglement (Callon and Rabeharisoa 2004) between technologies, practices and subjectivities. The paper is based on four months of participant observations and 17 in-depth interviews with elderly persons conducted at three...

  7. Is herpes zoster an additional complication in old age alongside comorbidity and multiple medications? Results of the post hoc analysis of the 12-month longitudinal prospective observational ARIZONA cohort study

    Pickering, Gisèle; Gavazzi, Gaëtan; Gaillat, Jacques; Paccalin, Marc; Bloch, Karine; Bouhassira, Didier


    Objectives To examine the burden of comorbidity, polypharmacy and herpes zoster (HZ), an infectious disease, and its main complication post-herpetic neuralgia (PHN) in young (50–70 years of age: 70−) and old (≥70 years of age: 70+) patients. Design Post hoc analysis of the results of the 12-month longitudinal prospective multicentre observational ARIZONA cohort study. Settings and participants The study took place in primary care in France from 20 November 2006 to 12 September 2008. Overall, 644 general practitioners (GPs) collected data from 1358 patients aged 50 years or more with acute eruptive HZ. Outcome measures Presence of HZ-related pain or PHN (pain persisting >3 months) was documented at day 0 and at months 3, 6, and 12. To investigate HZ and PHN burden, pain, quality of life (QoL) and mood were self-assessed using validated questionnaires (Zoster Brief Pain Inventory, 12-item Short-Form health survey and Hospital Anxiety and Depression Scale, respectively). Results As compared with younger patients, older patients more frequently presented with comorbidities, more frequently took analgesics and had poorer response on all questionnaires, indicating greater burden, at inclusion. Analgesics were more frequently prescribed to relieve acute pain or PHN in 70+ than 70− patients. Despite higher levels of medication prescription, poorer pain relief and poorer response to all questionnaires were reported in 70+ than 70− patients. Conclusions Occurrence of HZ and progression to PHN adds extra burden on top of pharmacological treatment and impaired quality of life, especially in older patients who already have health problems to cope with in everyday life. PMID:26892790

  8. Skin Aging

    ... too. Sunlight is a major cause of skin aging. You can protect yourself by staying out of ... person has smoked. Many products claim to revitalize aging skin or reduce wrinkles, but the Food and ...

  9. Aging mechanisms

    Takahashi, Yoshiko; Kuro-o, Makoto; Ishikawa, Fuyuki


    Aging (senescence) has long been a difficult issue to be experimentally analyzed because of stochastic processes, which contrast with the programmed events during early development. However, we have recently started to learn the molecular mechanisms that control aging. Studies of the mutant mouse, klotho, showing premature aging, raise a possibility that mammals have an “anti-aging hormone.” A decrease of cell proliferation ability caused by the telomeres is also t...

  10. Happy Aging



    Aging is a normal physiological process in human life.The decline in the ability to repair and regenerate predisposes the aging person to develop disabling problems in the cardiovascular and skeletal systems.Full awareness of aging problems and advocations on the means to prevent their occurrence are mounting.European and US groups rely on scientific,target-oriented means to treat aging manifestations. Oriental medicine aims at prevention,using nutrition and exercise to maintain internal harmony.

  11. Population Aging

    Weil, David N.


    Population aging is primarily the result of past declines in fertility, which produced a decades long period in which the ratio of dependents to working age adults was reduced. Rising old-age dependency in many countries represents the inevitable passing of this %u201Cdemographic dividend.%u201D Societies use three methods to transfer resources to people in dependent age groups: government, family, and personal saving. In developed countries, families are predominant in supporting children, w...

  12. Creative Aging.

    Ager, Charlene Lee; And Others


    Explores some divergent attitudes toward aging, negative as well as positive. Presents a neurophysiological framework to support the belief that aging is an active and creative process. Explores physical, psychological, and sociological aspects, and identifies three factors in the creative aging process. (Author/JAC)

  13. Skin Aging

    Your skin changes as you age. You might notice wrinkles, age spots and dryness. Your skin also becomes thinner and loses fat, making it ... heal, too. Sunlight is a major cause of skin aging. You can protect yourself by staying out ...

  14. Ageing Polulations

    Christiansen, Terkel; Lauridsen, Jørgen Trankjær; Bech, Mickael


    An ageing society is characterised by an increasing median age of the population. The purpose of this chapter is to document the existing knowledge about the association between population ageing and health care expenditure, and to supplement this overview by a summary of our original research. S...

  15. Interpreting spotted dolphin age distributions

    Barlow, Jay; Hohn, Aleta A.


    Previous work has determined the age distribution from a sample of spotted dolphins (Stenella attenuata) killed in the eastern Pacific tuna purse-seine fishery. In this paper we examine the usefulness of this age distribution for estimating natural mortality rates. The observed age distribution has a deficiency of individuals from 5-15 years and cannot represent a stable age distribution. Sampling bias and errors in age interpretation are examined as possible causes of the "dip" in the obs...

  16. Successful ageing

    Kusumastuti, Sasmita; Derks, Marloes G M; Tellier, Siri;


    curvilinear pattern with the lowest point at middle age but increases thereafter up to very old age. OBJECTIVE: To shed further light on this paradox, we reviewed the existing literature on how scholars define successful ageing and how they weigh the contribution of health and functioning to define success....... METHODS: We performed a novel, hypothesis-free and quantitative analysis of citation networks exploring the literature on successful ageing that exists in the Web of Science Core Collection Database using the CitNetExplorer software. Outcomes were visualized using timeline-based citation patterns. The......BACKGROUND: Ageing is accompanied by an increased risk of disease and a loss of functioning on several bodily and mental domains and some argue that maintaining health and functioning is essential for a successful old age. Paradoxically, studies have shown that overall wellbeing follows a...

  17. Skin aging:

    Puizina-Ivić, Neira


    There are two main processes that induce skin aging: intrinsic and extrinsic. A stochastic process that implies random cell damage as a result of mutations during metabolic processes due to the production of free radicals is also implicated. Extrinsic aging is caused by environmental factors such as sun exposure, air pollution, smoking, alcohol abuse, and poor nutrition. Intrinsicaging reflects the genetic background and depends on time. Various expressions of intrinsic aging include smooth, ...

  18. Clinical observation of suanzaoren granules on insomnia of the middle age and elderly patients%酸枣仁颗粒治疗中老年失眠症临床疗效观察

    高声传; 王沈歌; 陈卫东


    Objective To explore the effect of suanzaoren granules on insomnia of the middle age and elder patients. Methods 140 middle age and elderly patients ( 45 ~75 year-old )with insomnia were divided into two groups according to random number table. Treatment group( n =70 )were treated with suanzaoren granules,8 g for each time, tid;control group( n =70 )were treated with diazepam tablets,5 mg per time,qn. The course of treatment was 15 d,and the patients were treated for two courses. The clinical syndromes of insomnia were observed. Results The effective rate was 91. 5% in treatment group and 72. 9% in control group, there were significant differences between the two groups( P <0. 05 ). Conclusion Suanzaoren granules on insomnia of the middle age and elderly patients is better than diazepam tablets.%目的 观察酸枣仁颗粒剂治疗中老年失眠症的临床疗效.方法 将140例45~75岁中老年失眠症患者按随机数字表法随机分为2组.治疗组70例,给予酸枣仁颗粒剂,8 g/次,3次/d;对照组70例,给予地西泮片,5 mg/次,每晚1次.15 d为1个疗程,共治疗2个疗程.观察患者临床疗效.结果 治疗组有效率为91.5%,对照组有效率为72.9%,两组总有效率比较差异有统计学意义(P<0.05).结论 酸枣仁颗粒治疗中老年失眠症效果优于地西洋.

  19. Ageing management

    Ageing management is generally defined in a broad sense covering not only ageing management of hardware (structures, systems and components), but also management issues such as keeping up with developments in state-of-the-art technology and the latest management practices. The importance assigned to traditional ageing management, in terms of issues related to hardware degradation problems, is clearly very high. The other aspects, for example developments in engineering or management, are considered important as well, but are less emphasized. Plant ageing management is composed of the following necessary elements, which are all linked together: understanding and knowledge of ageing-related damage mechanisms, including benchmarking of the consequences of damage mechanisms into macroscopic behaviour of materials and structures under applicable conditions; predictive models to extrapolate behaviour of systems, structures or components up to a defined time; qualified methods for detection and surveillance of ageing degradation; qualified mitigation, repair and replacements measures; reliable plant documentation, including optimisation of the ageing management programme based on current understanding and knowledge and periodic self-assessment; availability of a technical service and knowledge base. The subject of plant ageing management has gained increasing attention over the past years, notably as more nuclear power plants across the world are being considered for lifetime extension. In this context, the NEA has conducted numerous technical studies to assess the impact of ageing mechanisms on safe and reliable plant operation. International research activities have also been initiated or are under way to provide the technical basis for decision making. This article provides an overview of some of the activities and accomplishments of the NEA Committee on the Safety of Nuclear Installations (CSNI) Working Group on the Integrity and Ageing of Components and Structures

  20. Perceived age as a biomarker of ageing: a clinical methodology

    Gunn, David A; Murray, Peter G; Tomlin, Cyrena C;


    facial ageing is detailed. The methodology utilises facial photographs of subjects to present images to large numbers of age assessors who are primarily nationals of the country of study origin. In five observational studies in five different countries involving 874 female subjects it was found that...... measure when large numbers of adult age assessors are used and can be utilised globally in studies to investigate facial ageing....

  1. Healthy Ageing

    Schans, Cees van der


    Presentatie gehouden bij de bijeenkomst voor het Regionaal Genootschap Fysiotherapie Het Noorden op 10 februari te Marum, over het belang van fysieke activiteit voor healthy ageing en de rol van de fysiotherapeut hierin

  2. [Normal aging and cognition].

    Ska, Bernadette; Joanette, Yves


    It is now well documented that normal aging modifies the cognitive functioning and most observations suggest that cognition evolves in the direction of deterioration. The more frequently impaired functions are memory, attention and visual-spatial abilities. On the other hand, some abilities seem to increase, such as vocabulary. Considering the aging effect on cognition, questions remain regarding directionality, universality and reversibility. A great variability in aged related impacts is observed among subjects and among cognitive domains. Some individuals evolved more rapidly than others. Some cognitive functions are more affected by aging than others. General and specific factors are hypothesized to explain the aged related cognitive decline. Among them, educational level, health, cognitive style, life style, personality, are likely to modulate the aged related cognitive evolution by influencing attentional resources and cerebral plasticity. Cognitive resources are essential to develop adaptative strategies. During the life span, resources are activated and increased by learning and training. Considering the role of cognitive resources, successful aging is dependent on several conditions : absence of disease leading to a loss of autonomy, maintenance of cognitive and physical activities, and active and social engaged lifestyle. PMID:16527210

  3. 中老年女性糖尿病合并泌尿道感染48例临床观察%Clinical observation of 48 middle and aged women with diabetes mellitus complicating urinary tract infection

    冯琴琴; 王宏钊


    Objective To observe and analyze the clinical differences between the patients with diabetes mellitus ( DM ) complicating urinary tract infection and those with simple urinary tract infection among middle and aged women. Methods The clinical manifestations and treatment between 48 cases with DM complicating urinary tract infection and 24 cases with simple urinary tract infection were analyzed and compared. Results The clinical symptoms of DM complicating urinary tract infection among females were manifold and clinical manifestations were concealed. The incidence rate of irritation sign of bladder was significantly lower than that among patients with simple urinary tract infection ( 58. 3% vs 100. 0% , χ2= 13. 846, P < 0. 01 ). The mean course of treatment in the group of DM complicating urinary tract infection was 15. 0 ± 8. 0 days, which was significantly longer than that in the group of simple urinary tract infection ( 6. 0 ± 3.2 days, t=5.289, P<0. 01 ). Conclusion Exploring the symptoms and clinical course of DM complicating urinary tract infection in middle and aged women is helpful to improve clinical efficacy and prognosis.%目的 观察分析中老年女性糖尿病合并泌尿道感染患者与单纯泌尿道感染患者的临床差异.方法 对比分析48例女性糖尿病合并泌尿道感染者与24例单纯泌尿道感染患者的临床表现及治疗效果.结果 女性糖尿病合并泌尿道感染患者的临床症状多样,表现隐匿,其膀胱刺激症状的出现率明显低于单纯性泌尿道感染患者(58.3% vs 100.0%,χ2=13.846,P<0.05).糖尿病合并泌尿道感染组平均疗程为15.0±8.0天,明显长于单纯泌尿道感染组的6.0±3.2天(t=5.289,P<0.01).结论 探索中老年女性糖尿病合并泌尿道感染者的症状及临床疗程特点,将有利于提高临床疗效和改善预后.

  4. Risk factors for mortality from acute lower respiratory infections (ALRI in children under five years of age in low and middle-income countries: a systematic review and meta-analysis of observational studies.

    Michela Sonego

    Full Text Available OBJECTIVE: To evaluate risk factors for death from acute lower respiratory infections (ALRI in children in low- and middle-income countries. DESIGN: Systematic review and meta-analysis. STUDY SELECTION: Observational studies reporting on risk factors for death from ALRI in children below five years in low- and middle income countries. DATA SOURCES: Medline, Embase, Global Health Library, Lilacs, and Web of Science to January 2014. RISK OF BIAS ASSESSMENT: Quality In Prognosis Studies tool with minor adaptations to assess the risk of bias; funnel plots and Egger's test to evaluate publication bias. RESULTS: Out of 10,655 papers retrieved, 77 studies from 39 countries (198,359 children met the inclusion criteria. Host and disease characteristics more strongly associated with ALRI mortality were: diagnosis of very severe pneumonia as per WHO definition (odds ratio 9.42, 95% confidence interval 6.37‒13.92; age below two months (5.22, 1.70‒16.03; diagnosis of Pneumocystis Carinii (4.79, 2.67‒8.61, chronic underlying diseases (4.76, 3.27‒6.93; HIV/AIDS (4.68, 3.72‒5.90; and severe malnutrition (OR 4.27, 3.47‒5.25. Socio-economic and environmental factors significantly associated with increased odds of death from ALRI were: young maternal age (1.84, 1.03‒3.31; low maternal education (1.43, 1.13‒1.82; low socio-economic status (1.62, 1.32‒2.00; second-hand smoke exposure (1.52, 1.20 to 1.93; indoor air pollution (3.02, 2.11‒4.31. Immunisation (0.46, 0.36‒0.58 and good antenatal practices (0.50, 0.31‒0.81 were associated with decreased odds of death. CONCLUSIONS: Host and disease characteristics as well as socio-economic and environmental determinants affect the risk of death from ALRI in children. Together with the prevention and treatment of chronic diseases, interventions to modify underlying risk factors such as poverty, lack of female education, and poor environmental conditions, should be considered among the strategies to

  5. Age-related oral changes.

    Mckenna, Gerald


    Age-related oral changes are seen in the oral hard and soft tissues as well as in bone, the temporomandibular joints and the oral mucosa. As older patients retain their natural teeth for longer, the clinical picture consists of normal physiological age changes in combination with pathological and iatrogenic effects. Clinical Relevance: With an ageing population retaining more of its natural teeth for longer, dental professionals should expect to observe oral age changes more frequently.

  6. Bone age in cerebral palsy

    Miranda, Eduardo Régis de Alencar Bona; Palmieri, Maurício D'arc; de Assumpção, Rodrigo Montezuma César; Yamada, Helder Henzo; Rancan, Daniela Regina; Fucs, Patrícia Maria de Moraes Barros


    Objective To compare the chronological age and bone age among cerebral palsy patients in the outpatient clinic and its correlation with the type of neurological involvement, gender and functional status. Methods 401 patients with spastic cerebral palsy, and ages ranging from three months to 20 years old, submitted to radiological examination for bone age and analyzed by two independent observers according Greulich & Pyle. Results In the topographic distribution, there was a significant delay (p

  7. Telomeres and reproductive aging.

    Keefe, David L; Liu, Lin


    Infertility, miscarriage and aneuploid offspring increase with age in women, and meiotic dysfunction underlies reproductive aging. How aging disrupts meiotic function in women remains unclear, but as women increasingly delay having children, solving this problem becomes an urgent priority. Telomeres consist of a (TTAGGG)(n) repeated sequence and associated proteins at chromosome ends, mediate aging in mitotic cells and may also mediate aging during meiosis. Telomeres shorten both during DNA replication and from the response to oxidative DNA damage. Oocytes do not divide in adult mammals, but their precursors do replicate during fetal oogenesis; eggs ovulated from older females have traversed more mitotic cell cycles before entering meiosis during fetal oogenesis than eggs ovulated from younger females. Telomeres also would be expected to shorten from inefficient DNA repair of oxidative damage, because the interval between fetal oogenesis and ovulation is exceptionally prolonged in women. We have tested the hypothesis that telomere shortening disrupts meiosis by shortening telomeres experimentally in mice, which normally do not exhibit age-related meiotic dysfunction. Interestingly, mouse telomeres are much longer than human telomeres, but genetic or pharmacological shortening of mouse telomeres recapitulates in mice the human reproductive aging phenotype as the mouse telomeres reach the length of telomeres from older women. These observations led us to propose a telomere theory of reproductive aging. Moreover, chronological oxidative stress increases with reproductive aging, leading to DNA damage preferentially at (TTAGGG)(n) repeats. Finally, if telomeres shorten with aging, how do they reset across generations? Telomerase could not play a significant role in telomere elongation during early development, because this enzyme is not active until the blastocyst stage, well after the stage when telomere elongation takes place. Rather, telomeres lengthen during the

  8. Martian ages

    The subjects of this paper are a discussion of the methodology of relative age determination by impact crater statistics, a comparison of currently proposed Martian impact chronologies for the determination of absolute ages from crater frequencies, a report on our work of dating Martian volcanoes and erosional features by impact crater statistics, and an attempt to understand the main features of Martian history through a synthesis of our crater frequency data and those published by other authors. Two cratering chronology models are presented and used for inference of absolute ages from crater frequency data: model 1, with nearly equal Martian and lunar cratering rates around (ca.) 4- to 10-km crater sizes, and model II. equivalent to model I for ages >3.5 x 109 years but with a factor of 2 higher Martian cratering rate at ages 9 years. Those model cratering chronologies are applied to the data. The interpretation of all crater frequency data available and tractable by our methodology leads to a global Martian geological history that is characterized essentially by two epochs of activity. The division between the two epochs is measured at a cumulative crater frequency value for 1-km craters (crater retention age) of N(1) = 8 x 10-4 (km-2) corresponding to an absolute age of ca. 3 x 109 years (applying model I cratering chronology) and of ca. 1.5 x 109 years (applying model II cratering chronology). In the ancient epoch all major events like emplacement of the plains lavas, the piling up of most volcanic constructs, and large-scale erosion of channels and mensae (highland/northern lowland boundary) have taken place. During the younger epoch, only the big Tharsis shield volcanoes were active, and some minor erosion took place. This means that Mars is not a youthful planet but an ancient one with respect to most of its surface features

  9. Premature aging

    The hypothesis that radiation may accelerate aging phenomenon has been studied extensively, using the population of A-bomb survivors. In this paper, non-specific radiation-induced premature aging is discussed with a review of the literature. Cardiac lipofuscin, papillary fibrosis, aortic extensibility, hexamine/collagen ratio in the skin and aorta, testicular changes, giant hepatic cell nucleus, and neurofibril changes have so far been studied pathologically in the context of A-bomb radiation. Only testicular sclerosis has been found to correlate with distance from the hypocenter. Suggestive correlation was found to exist between the hexamine/collagen ratio in the skin and aorta and A-bomb radiation. Grip strength and hearing ability were decreased in the group of 100 rad and the group of 50-99 rad, respectively. The other physiological data did not definitely correlate with A-bomb radiation. Laboratory data, including erythrocyte sedimentation rate, α and β globulin levels, phytohemagglutinin reaction, T cell counts, erythrocyte glycophorin-A, the incidence of cerebral stroke, ischemic heart disease, and cataract were age-dependent and correlated with A-bomb radiation. These findings indicated that the occurrence of arteriosclerosis-related diseases, changes in immunological competence, and some pathological and physiological findings altered with advancing age, suggesting the correlation with A-bomb radiation. In general, it cannot be concluded that there is a positive correlation between A-bomb radiation and the premature aging. (N.K.) 51 refs

  10. Successful ageing

    Bülow, Morten Hillgaard; Söderqvist, Thomas


    prevention strategies; and the importance of individual, societal and scientific conceptualisations and understandings of ageing. By presenting an account of the recent historical uses, interpretations and critiques of the concept, the article unfolds the practical and normative complexities of ‘ successful......Since the late 1980s, the concept of ‘ successful ageing’ has set the frame for discourse about contemporary ageing research. Through an analysis of the reception to John W. Rowe and Robert L. Kahn's launch of the concept of ‘ successful ageing’ in 1987, this article maps out the important themes...

  11. Aging Differently

    Zajitschek, Felix; Jin, Tuo; Colchero, Fernando;


    Diet effects on age-dependent mortality patterns are well documented in a large number of animal species, but studies that look at the effects of nutrient availability on late-life mortality plateaus are lacking. Here, we focus on the effect of dietary protein content (low, intermediate, and high...... statistical approach based on Bayesian inference of age-specific mortality rates and found a deceleration of late-life mortality rates on all diets in males but only on the intermediate (standard) diet in females. The difference in mortality rate deceleration between males and females on extreme diets...

  12. Age management

    Kratochvilová, Markéta


    The Bachelor‘s thesis focuses on Age Management and its areas of influence. This term is most often discussed in connection with a problem which is currently common for all European Union countries – the ageing of society. In the near future, the structure of society is very likely to be altered drastically as a consequence of this phenomenon and due to the severity of the effects, it is necessary to begin addressing this problem. The first part of the thesis concerns itself with processing d...

  13. Observe Your Shadow

    Rovšek, Barbara


    Observe Your Shadow was the title of an observational experiment that was, among others, conducted in the scope of the past year's (2014-2015) first Slovene science competition for elementary school pupils between the ages of 6 and 13. The main reason for establishing a new science competition was popularization of science and its experimental…

  14. Aging Random Walks

    Böttcher, S


    Aging refers to the property of two-time correlation functions to decay very slowly on (at least) two time scales. This phenomenon has gained recent attention due to experimental observations of the history dependent relaxation behavior in amorphous materials (``Glasses'') which pose a challenge to theorist. Aging signals the breaking of time-translational invariance and the violation of the fluctuation dissipation theorem during the relaxation process. But while the origin of aging in disordered media is profound, and the discussion is clad in the language of a well-developed theory, systems as simple as a random walk near a wall can exhibit aging. Such a simple walk serves well to illustrate the phenomenon and some of the physics behind it.

  15. Ageing and skills

    Desjardins, Richard; Warnke, Arne Jonas

    The relationship between ageing and skills is becoming an important policy issue, not least in the context of population ageing. Data from the Programme for the International Assessment of Adult Competencies (PIAAC) will potentially add considerably to the understanding of the relationship between...... ageing and foundation skills. In particular, the fact that data from the 1994-1998 International Adult Literacy Survey (IALS) and the 2003-2007 Adult Literacy and Lifeskills Survey (ALL) will be linked with PIAAC offers a unique opportunity to examine trends over time at the cohort level for a wide range...... of countries. Specifically, repeated measures will enable an analysis of whether there is skill gain and skill loss over the lifespan of cohorts and overtime between cohorts. This is especially important because age-skill profiles observed on the basis of a single cross-section are difficult to...

  16. Age Spots

    ... for treating age spots include: Improved appearance. Enhanced self-esteem. Promotion of better skin health. What you need ... 480px View Render 320px View Connect with ASDS: Facebook LinkedIn YouTube Twitter Quick Links About ASDS Advocacy ...

  17. Fuel cycle: the transition between the third and the fourth generation of reactors; Cycle du combustible: faire la transition vers les 3eme et 4eme generations de reacteurs



    Many challenges arrive today for the french research and development on the fuel cycle: promote the industrial technologies, improve the world increase of the nuclear and adapt the fuel cycle technologies to the future reactors. In this framework the report presents after a recall on the fuel cycle, the researches on the fuel, the optimization of the recycling, the wastes management, the simulation and Phenix an experimentation tool for the fuel. (A.L.B.)

  18. Pump used as a turbine (PAT) with flow control - Part 4: Sizing the new spiral casing; Petites centrales hydrauliques. Pompe fonctionnant en turbine avec reglage du debit (Pat-Francis). 4eme partie: dimensionnement et construction de la bache spirale

    Chapallaz, J.-M.


    This fourth and final part of a final report for the Swiss Federal Office of Energy (SFOE) discusses the use of a pump equipped with variable guide vanes, similar to a Francis turbine. This fourth part of a four-part article deals with the selection of a pump and describes the general lay-out of the new spiral casing to be adapted for use in the PAT-Francis turbine. The parameters to be taken into account are looked at and calculation examples are presented. Proposals for a simplified construction are examined.

  19. Healthy ageing

    Harrison, Adrian Paul; Brüggemann, Dagmar Adeline; Bartels, Else Marie;


    The study employed mechanical stretching in vitro of sections of abdominal aorta of elderly mice to investigate any benefits of oral treatment with alpha-ketoglutarate (AKG) on arterial elasticity. Eighteen female mice (50-weeks-old) were assigned to a control (2% w/v) Na2-AKG or (2% w/v) a Ca-AK...... investigation as a candidate for therapies targeting arterial stiffening with age....

  20. Aging Perspectives

    Cosco, Theodore D; David Brehme; Nora Grigoruta; Lisa-Katrin Kaufmann; Liis Lemsalu; Ruth Meex; Angela Schuurmans; Neslihan Sener


    Despite the proliferation of successful ageing (SA) research, the literature is dominated by researcher-driven Anglophone conceptualisations. To date, lay perspectives of SA have not been examined in Europe or Turkey. The current study aims to conduct a mixed-methods examination of conceptualisations of SA in seven underrepresented countries. Using snowball sampling via social media sites, an online survey consisting of established closed-ended and open-ended items – translated into seven lan...

  1. Golden Age


      Sometimes, a moment can announce the end of an age. The gold market is like that. Within two transaction days, the gold slumped by 13%and saw a 25%tumble from the high point in August 2011. According to the classic investment theory, a 20%-above decline means the shift from“a bull”to“a bear”market.   The super bear market of gold has lasted a dozen years. But the bull-to-bear shift was completed within only 20 minutes. Wall Street’s analysts and ordinary Chinese people had different understandings to the golden age.   Expecting a bear market, Wall Street continuously dumped gold, resulting in a diving of gold price. Seeing the benefits, leisure Chinese madams made a gold rush, causing a slight bounce of gold price. On April 23, renowned investment bank Goldman Sachs suspended the short sale. So,“Chinese aunts”beating back Wall Street’s analysts became the hottest topic online for the time being.   What are the decisive factors for the crash of gold price? Will the gold market complete a real bull-to-bear shift? Will the golden age of gold be farther or nearer?

  2. The aging male project

    Farid Saad


    With an increasing life expectancy and a decreasing reproduction rate, the population structure changes. A Jenapharm R & D program investigates the endocrinology of aging men. In men, a decrease in production of sex steroids and other hormones with age can be observed. The typical patterns of daily rhythmicity become less distinct. This is part of a very complex picture in which not only isolated hormones are involved, but also the influence of hormones on each other. Many factors from th...

  3. Aging Perspectives

    Theodore D Cosco


    Full Text Available Despite the proliferation of successful ageing (SA research, the literature is dominated by researcher-driven Anglophone conceptualisations. To date, lay perspectives of SA have not been examined in Europe or Turkey. The current study aims to conduct a mixed-methods examination of conceptualisations of SA in seven underrepresented countries. Using snowball sampling via social media sites, an online survey consisting of established closed-ended and open-ended items – translated into seven languages – was administered. Grounded theory methods and descriptive statistics were used to analyse qualitative and quantitative data, respectively.

  4. Ice ages

    The Earth's climate undergoes great changes in cycles of 104 to 105 years. Deep sea sediments contain proof of these changes. The critical parameter is the O18/O16 isotope ratio. The astronomical theory is discussed of ice ages based on the changes in the shape of the Earth's orbit around the sun. Forecasts for the future are given - in the coming years the climate is expected to get warmer owing to increased CO2 levels in the atmosphere, and then a long cooler period is expected to follow. (M.D.)

  5. Aging Blepharoplasty

    Inchang Cho


    Full Text Available In performing upper blepharoplasty in the elderly, looking younger and keeping the eyelidsharmonious with the rest of the face have to be achieved at the same time. The most importantgoal in upper blepharoplasty for aging is correcting the drooping upper eyelid skin, and inthis process, the surgeon may or may not create a double eyelid fold. The pros and cons haveto be fully discussed with the patient, but the author personally prefers creating a doublefold unless the patient refuses, because it is efficient in correcting and preventing furtherdrooping of the skin. In most patients, the brow is elevated to compensate for the droopingeyelid, and when the drooping is corrected, brow ptosis may ensue. The surgeon has to preparefor these consequences before performing the procedure, and estimate the exact amountof skin to be excised. In the elderly, the skin and the orbicularis oculi muscle is thin, with adecreased amount of subcutaneous fat and retro-orbicularis oculi fat, and in most cases,excision of the skin alone is enough to correct the deformity. Removing large portions ofsoft tissue may also prolong the recovery period. Unlike younger patients, the lower skinflap should not be stretched too much in the elderly, as it may create an aggressive lookingappearance. A few wrinkles in the lower flap should remain untouched to create a naturallook. In this article, the author’s own methods of performing an aging blepharoplasty aredescribed specifically, with a step-by-step guide and surgical tips.

  6. Aging blepharoplasty.

    Cho, Inchang


    In performing upper blepharoplasty in the elderly, looking younger and keeping the eyelids harmonious with the rest of the face have to be achieved at the same time. The most important goal in upper blepharoplasty for aging is correcting the drooping upper eyelid skin, and in this process, the surgeon may or may not create a double eyelid fold. The pros and cons have to be fully discussed with the patient, but the author personally prefers creating a double fold unless the patient refuses, because it is efficient in correcting and preventing further drooping of the skin. In most patients, the brow is elevated to compensate for the drooping eyelid, and when the drooping is corrected, brow ptosis may ensue. The surgeon has to prepare for these consequences before performing the procedure, and estimate the exact amount of skin to be excised. In the elderly, the skin and the orbicularis oculi muscle is thin, with a decreased amount of subcutaneous fat and retro-orbicularis oculi fat, and in most cases, excision of the skin alone is enough to correct the deformity. Removing large portions of soft tissue may also prolong the recovery period. Unlike younger patients, the lower skin flap should not be stretched too much in the elderly, as it may create an aggressive looking appearance. A few wrinkles in the lower flap should remain untouched to create a natural look. In this article, the author's own methods of performing an aging blepharoplasty are described specifically, with a step-by-step guide and surgical tips. PMID:24086798

  7. Skin Care and Aging

    ... Home » Skin Care and Aging Heath and Aging Skin Care and Aging Dry Skin and Itching Bruises Wrinkles Age Spots ... doctor. For More Information About Skin Care and Aging American Academy of Dermatology 1-866-503-7546 ( ...

  8. Dominant perceptions on the age

    Komatina Slavica


    Full Text Available Contemporary developed society, despite the fact that it is constantly and intensively ageing, is characterized by deeply rooted numerous negative stereotypes on old people and old age as a life period. The study of dominant perceptions on the age of Belgrade population takes not only the universal character of negative connotation of old age into consideration, but also the concrete unfavorable social context. The delicate problematic of stereotypes on old age and old people has been analyzed mostly indirectly, through questions on the beginning of old age, advantages and difficulties which we experience during ageing, the first subjective conscious encounter with one’s own ageing, the concept of ideal old age, changes in the persons traits and directly through questions on dominant negative perceptions which prevail on old people in our surrounding. Ageing in the Belgrade milieu is most commonly identified with illness and with the decline of physical potentials, and at the same time a number of other negative qualifications of old age as well. Research results indicate to a pronounced ambivalent standpoint towards ageing, to different observation of one’s own to old age of other people, to different consideration of old age among the sexes and to obvious aversion towards old people. This is expected, taking into consideration that living and ageing are developing nowadays under aggressive influence of contemporary mass culture which affirms youth, beauty, physical strength, health as dominant values, namely everything that is contrary to ageing and old age. On the other hand, our society is today confronted with, as well as in the near past, exceptional political, economic and cultural difficulties which cause specific problems with various age groups, as well as the lowering of the level of mutual endurance and tolerance. The atmosphere of straining the old people and emergence of new antagonisms causes the intensification of

  9. Population aging and legal retirement age

    Lacomba, Juan Antonio; Lagos, Francisco Miguel


    This paper analyzes the effects of population aging on the preferred legal retirement age. What is revealed is the crucial role that the indirect ???macro??? effects resulting from a change in the legal retirement age play in the optimal decision. Two Social Security systems are studied. Under a defined contribution scheme aging lowers the preferred legal retirement age. However, under a defined pension scheme the retirement age is delayed. This result shows the relevance of correctly c...

  10. Observation of the effect of Hongyangfuzheng oral liquid on exercise capacity and aging mechanism%红阳扶正口服液增强运动能力和抗衰老机理的实验观察

    董彩霞; 张彩云; 滕宝霞


    目的 研究红阳扶正口服液对增强运动能力和抗衰老作用的机理.方法 小鼠口服红阳扶正口服液10 d,每鼠尾部负重为体重的5%,力竭后,摘取眼球取血,3000 r/min离心10 min,检测血清乳酸、乳酸脱氢酶、肝糖原、尿素氮、丙二醛和超氧化物歧化酶(SOD),测定红阳扶正口服液对衰老模型小鼠脑中SOD和丙二醛含量的影响.结果 红阳扶正口服液能明显降低血清中乳酸、尿素氮、丙二醛的含量,增加小鼠血清中乳酸脱氢酶、SOD和肝糖原的含量(P<0.05);红阳扶正口服液降低衰老模型小鼠大脑中丙二醛的含量,增加大脑SOD活性.结论 红阳扶正口服液具有增加运动能力和抗衰老的作用.%Objective To investigate the effect of Hongyangfuzheng oral liquid (HOL) on exercise capacity and aging mechanism. Methods Through oral administration with HOL 10 days, each rat tail weight for weight 5%, after exhaustive, removal of eye blood, centrifugal 10 min (3000 r/min). The content of serum lactic acid (LA), lactate dehydrogenase (LAD), hepatic glycogen, blood urea nitrogen (BUN), malondialdehyde (MDA) and superoxide dismutase (SOD) was detected. MDA and SOD in the brain of mice was detected too. Results HOL obviously decrease the content of serum LA, BUN, MDA. LAD, SOD and hepatic glycogen increased in mice serum (P<0.05). HOL reduced the aging model mice brain MDA content, increased SOD activity in brain. Conclusion HOL can increase of exercise capacity and the anti aging effect.

  11. Aging and the intestine

    Laurie Drozdowski; Alan BR Thomson


    Over the lifetime of the animal, there are many changes in the function of the body's organ systems. In the gastrointestinal tract there is a general modest decline in the function of the esophagus, stomach, colon,pancreas and liver. In the small intestine, there may be subtle alterations in the intestinal morphology, as well as a decline in the uptake of fatty acids and sugars.The malabsorption may be partially reversed by aging glucagon-like peptide 2 (GLP2) or dexamethasone.Modifications in the type of lipids in the diet will influence the intestinal absorption of nutrients: for example, in mature rats a diet enriched with saturated as compared with polysaturated fatty acids will enhance lipid and sugar uptake, whereas in older animals the opposite effect is observed. Thus, the results of studies of the intestinal adaptation performed in mature rats does not necessarily apply in older animals. The age-associated malabsorption of nutrients that occurs with aging may be one of the several factors which contribute to the malnutrition that occurs with aging.

  12. The Observation on Development of Thickness of Cortical Bone in Children of Different Age%不同年龄组小儿骨皮质发育状况观察

    宁刚; 吴康敏; 伍家农; 张光鹏; 杨定焯


    【 Objective】 In order to find out the pattern of development in cortical bone, a study of cortical bone in normal in-fants、 children、adolescence and adults were carried out. 【Methods】 The authors measured the transverse and inner diameter inmidpoint of the second metacarpal bone from 1 017 X- ray films of right wrist of normal infants、children、 adolescence and adults inthe urban and of infants in the suburban. The thickness and index of cortical bone in midpoint of the second metacarpal were calculat-ed by Microsoft Excel 97. 【 Results】 The increase of thickness of cortical bone was respectively 3.06 mm、2.89 mm for boys andgirls from 1.0 to 15.0 vr of age ,the average amplitude was respectively 4.0% 、4.3%, the latter was 8.2% 、6.9% for male and fe-male infants , 2.3 %、 2.0 % for infancy and preschool children, 10.7 % for girls at 11~13yr of age ,7.8 % for boys of 13~15yr ofage. Between urban areas and a rural area there were not significant differences between the transverse diameters in the secondmetacarpal of boys and girls at 1.0yr of age, but the average thickness of cortical bone were decreased of 0.39 mm in rural area ( P< 0.001 ). 【Conclusions】 The thickness of cortical bone increased significantly with age in children and adolescence , the in-creased velocity was more rapid during infncy nd puberty , with the pek thickness of corticl bone round puberty.%【目的】通过对正常婴幼儿、青少年及部分成年人骨皮质发育的横向观察,了解小儿骨皮质发育的规律。【方法】市郊农村健康婴儿,城区婴幼儿、青少年及部分成年人,共1 017例摄右手腕正位X光片,测量第二掌骨中点横径及内径,用Microsoft Excel97软件计算出骨皮质厚度、皮质指数并作统计学处理。【结果】从1岁组到15岁组男、女童骨皮质厚度分别增加了3.06mm及2.89mm,平均年增幅分别为4.0%及4.3%;婴儿期平均年增幅分别为8.2

  13. Aging and Aged in Organized Crime.

    Amir, Menachem


    Examines problems of the aged in organized crime, basing discussion on organized crime bosses over age 60 operating in Italy, the United States, and Israel. Looks at problems stemming from normative system in organized crime, role of the aged, intergenerational problems, fears of the aged, excuses and justifications, standards of life, and…

  14. Oral Health and Aging

    ... please turn JavaScript on. Feature: Oral Health and Aging Oral Health and Aging Summer 2016 Table of Contents Jerrold H. Epstein, ... they may need. Read More "Oral Health and Aging" Articles Oral Health and Aging / 4 Myths About ...

  15. Skin Care and Aging

    ... page please turn Javascript on. Skin Care and Aging How Aging Affects Skin Your skin changes with age. It ... if they bother you. See additional resources on aging skin, including information on treatment options, specific conditions, ...

  16. The Biology of Aging.

    Sprott, Richard L.; And Others


    Thirteen articles in this special issue discuss aging theories, biomarkers of aging, aging research, disease, cancer biology, Alzheimer's disease, stress, oxidation of proteins, gene therapy, service delivery, biogerontology, and ethics and aging research. (SK)

  17. Aging in language dynamics.

    Animesh Mukherjee

    Full Text Available Human languages evolve continuously, and a puzzling problem is how to reconcile the apparent robustness of most of the deep linguistic structures we use with the evidence that they undergo possibly slow, yet ceaseless, changes. Is the state in which we observe languages today closer to what would be a dynamical attractor with statistically stationary properties or rather closer to a non-steady state slowly evolving in time? Here we address this question in the framework of the emergence of shared linguistic categories in a population of individuals interacting through language games. The observed emerging asymptotic categorization, which has been previously tested--with success--against experimental data from human languages, corresponds to a metastable state where global shifts are always possible but progressively more unlikely and the response properties depend on the age of the system. This aging mechanism exhibits striking quantitative analogies to what is observed in the statistical mechanics of glassy systems. We argue that this can be a general scenario in language dynamics where shared linguistic conventions would not emerge as attractors, but rather as metastable states.

  18. Predatory senescence in ageing wolves

    MacNulty, D.R.; Smith, D.W.; Vucetich, J.A.; Mech, L.D.; Stahler, D.R.; Packer, C.


    It is well established that ageing handicaps the ability of prey to escape predators, yet surprisingly little is known about how ageing affects the ability of predators to catch prey. Research into long-lived predators has assumed that adults have uniform impacts on prey regardless of age. Here we use longitudinal data from repeated observations of individually-known wolves (Canis lupus) hunting elk (Cervus elaphus) in Yellowstone National Park to demonstrate that adult predatory performance declines with age and that an increasing ratio of senescent individuals in the wolf population depresses the rate of prey offtake. Because this ratio fluctuates independently of population size, predatory senescence may cause wolf populations of equal size but different age structure to have different impacts on prey populations. These findings suggest that predatory senescence is an important, though overlooked, factor affecting predator-prey dynamics. ?? 2009 Blackwell Publishing Ltd/CNRS.

  19. Ageing in Communal Place

    Aarhus, Rikke; Ballegaard, Stinne Aaløkke; Grönvall, Erik;


    In this paper we adopt the position that design of social media for the elderly and virtual senior communities may be informed by studying ‘real’ senior communities. Since current research efforts target the role of social media and virtual communities for supporting seniors ageing in place, i...... how these findings apply to designers of social media technologies. .......e. in their homes, housing communities seem a natural place to begin this enquiry. We conducted observations and informal interviews in six different senior dwellings. In this paper we present the key findings from these visits related to social interaction and the formation of communities and explicate...

  20. Satellite observations


    In 1982 and 1983, six scientific satellites were operated successfully. Two of them, JIKIKEN and ISS-b, performed observations of the Earth's plasma environment. HINOTORI, the solar maximum satellite, observed a number of solar flares. HAKUCHO and newly launched TENMA conducted various observations of cosmic X-ray sources. HIMAWARI-2 is a meteorological satellite but its payload includes a solar particle monitor. EXOS-C was successfully launched in February, 1983, and participants in the MAP (Middle Atmosphere Program). Following these missions, the PLANET-A project comprising two missions, MS-T5 and PLANET-A, is under preparation for the participation in the international cooperative exploration of Comet P/Halley. The third X-ray astronomy satellite ASTRO-C is currently scheduled for 1987 launch.

  1. Observational $\\Delta\

    Hernández, Antonio García; Monteiro, Mário J P F G; Suárez, Juan Carlos; Reese, Daniel R; Pascual-Granado, Javier; Garrido, Rafael


    Delta Scuti ($\\delta$ Sct) stars are intermediate-mass pulsators, whose intrinsic oscillations have been studied for decades. However, modelling their pulsations remains a real theoretical challenge, thereby even hampering the precise determination of global stellar parameters. In this work, we used space photometry observations of eclipsing binaries with a $\\delta$ Sct component to obtain reliable physical parameters and oscillation frequencies. Using that information, we derived an observational scaling relation between the stellar mean density and a frequency pattern in the oscillation spectrum. This pattern is analogous to the solar-like large separation but in the low order regime. We also show that this relation is independent of the rotation rate. These findings open the possibility of accurately characterizing this type of pulsator and validate the frequency pattern as a new observable for $\\delta$ Sct stars.

  2. 微创种植技术在老年人牙种植术中应用的临床观察%The clinical observation of flapless technology in dental implantation for the aged

    杨懿; 郭家平; 马毅慧; 邱建勇; 何非


    Objective:To retrospectively study the clinical effect of minimally invasive implant technology in the el-derly patients was. Method:Retrospectively study the elderly patients who received 79 implant surgery,49 men,30 women, the average age of 67 years,and 97 implants total. Flapless group:35 people,including 23 men,12 female,47 implants. Con-ventional surgery group:44 people,28 male,16 female,50 implants. To evaluate the clinical effect of Operation time,Postop-erative pain,Postoperative bleeding,Postoperative swelling and implant success after comparison. Result:Compared with the results of the groups,the flapless group was significantly better than that of the conventional flap group,and the success rate of the implants was not significantly different between the two groups. Conclusion:The flapless technique is suitable for the elderly patients,and the clinical effect is definitive.%目的:回顾性研究微创种植技术在老年患者中应用的临床效果。方法:回访2009~2014年接受种植手术的老年患者79人,男49人,女30人,平均年龄67岁,植入种植体97颗,分为微创组和常规组。微创组35例,男23例,女12例,植入种植体47颗。常规组44例,男28例,女16例,植入种植体50颗。对比手术时间、术后疼痛反应,术后出血、肿胀及种植手术成功率,评价临床效果。结果:对比术后反应发生率,微创组明显少于常规组,种植手术成功率基本接近,两组间比较,差异无统计学意义。结论:在条件允许情况下,微创种植手术更适合老年患者应用,临床效果确定。

  3. Macroscopic observables

    We study macroscopic observables defined as the total value of a physical quantity over a collection of quantum systems. We show that previous results obtained for an infinite ensemble of identically prepared systems lead to incorrect conclusions for finite ensembles. In particular, exact measurement of a macroscopic observable significantly disturbs the state of any finite ensemble. However, we show how this disturbance can be made arbitrarily small when the measurements are of finite accuracy. We demonstrate a general trade-off between state disturbance and measurement coarseness as a function of the size of the ensemble. Using this trade-off, we show that the histories generated by any sequence of finite accuracy macroscopic measurements always generate a consistent family in the absence of large-scale entanglement for sufficiently large ensembles. Hence, macroscopic observables behave 'classically' provided that their accuracy is coarser than the quantum correlation length scale of the system. The role of these observable is also discussed in the context of NMR quantum information processing and bulk ensemble quantum state tomography

  4. Babylonian observations

    Brown, D.

    Very few cuneiform records survive from Mesopotamia of datable astronomical observations made prior to the mid-eighth century BC. Those that do record occasional eclipses, and in one isolated case the dates of the heliacal rising and setting of Venus over a few years sometime in the first half of the second millennium BC. After the mid-eighth century BC the situation changes dramatically. Incomplete records of daily observations of astronomical and meteorological events are preserved from c. 747 BC until the Christian Period. These records are without accompanying ominous interpretation, although it is highly probable that they were compiled by diviners for astrological purposes. They include numerous observations of use to historical astronomers, such as the times of eclipses and occultations, and the dates of comet appearances and meteor showers. The question arises as to why such records do not survive from earlier times; celestial divination was employed as far back as the third millenium BC. It is surely not without importance that the earliest known accurate astronomical predictions accompany the later records, and that the mid-eighth century BC ushered in a period of centralised Assyrian control of Mesopotamia and the concomitant employment by the Assyrian ruler of large numbers of professional celestial diviners. The programme of daily observations evidently began when a high premium was first set on the accurate astronomical prediction of ominous events. It is in this light that we must approach this valuable source material for historical astronomy.

  5. Flare Observations

    Benz Arnold O.


    Full Text Available Solar flares are observed at all wavelengths from decameter radio waves to gamma-rays at 100 MeV. This review focuses on recent observations in EUV, soft and hard X-rays, white light, and radio waves. Space missions such as RHESSI, Yohkoh, TRACE, and SOHO have enlarged widely the observational base. They have revealed a number of surprises: Coronal sources appear before the hard X-ray emission in chromospheric footpoints, major flare acceleration sites appear to be independent of coronal mass ejections (CMEs, electrons, and ions may be accelerated at different sites, there are at least 3 different magnetic topologies, and basic characteristics vary from small to large flares. Recent progress also includes improved insights into the flare energy partition, on the location(s of energy release, tests of energy release scenarios and particle acceleration. The interplay of observations with theory is important to deduce the geometry and to disentangle the various processes involved. There is increasing evidence supporting reconnection of magnetic field lines as the basic cause. While this process has become generally accepted as the trigger, it is still controversial how it converts a considerable fraction of the energy into non-thermal particles. Flare-like processes may be responsible for large-scale restructuring of the magnetic field in the corona as well as for its heating. Large flares influence interplanetary space and substantially affect the Earth’s lower ionosphere. While flare scenarios have slowly converged over the past decades, every new observation still reveals major unexpected results, demonstrating that solar flares, after 150 years since their discovery, remain a complex problem of astrophysics including major unsolved questions.

  6. Utilization of dental services in old age

    Nitschke, Ina; Stillhart, Angela; Kunze, Julia


    Regular utilization of dental services helps to improve and maintain oral and general health, even in old age. However, utilization behavior for dental services changes with age: preventive utilization behavior is often replaced by a symptom-driven one. With age, a decrease in the utilization of dental services can be observed, whilst the frequency of contact with physicians increases. The present review describes the current knowledge regarding the utilization of dental services in old age (...

  7. Dehydroepiandrosterone and age-related cognitive decline

    Sorwell, Krystina G.; Urbanski, Henryk F.


    In humans the circulating concentrations of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) decrease markedly during aging, and have been implicated in age-associated cognitive decline. This has led to the hypothesis that DHEA supplementation during aging may improve memory. In rodents, a cognitive anti-aging effect of DHEA and DHEAS has been observed but it is unclear whether this effect is mediated indirectly through conversion of these steroids to estradiol. Moreover, despite the de...

  8. Parental age, genetic mutation, and cerebral palsy.

    Fletcher, N A; Foley, J


    Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.

  9. Avoiding Aging? Social Psychology's Treatment of Age

    Barrett, Anne E.; Redmond, Rebecca; von Rohr, Carmen


    Population aging, in conjunction with social and cultural transformations of the life course, has profound implications for social systems--from large-scale structures to micro-level processes. However, much of sociology remains fairly quiet on issues of age and aging, including the subfield of social psychology that could illuminate the impact of…

  10. Observing environments

    Alrøe, Hugo Fjelsted; Noe, Egon


    Context: Society is faced with “wicked” problems of environmental sustainability, which are inherently multiperspectival, and there is a need for explicitly constructivist and perspectivist theories to address them. Problem: However, different constructivist theories construe the environment in...... different ways. The aim of this paper is to clarify the conceptions of environment in constructivist approaches, and thereby to assist the sciences of complex systems and complex environmental problems. Method: We describe the terms used for “the environment” in von Uexküll, Maturana & Varela, and Luhmann......, and analyse how their conceptions of environment are connected to differences of perspective and observation. Results: We show the need to distinguish between inside and outside perspectives on the environment, and identify two very different and complementary logics of observation, the logic of...

  11. The aging mouth: differentiating normal aging from disease.

    Lamster, Ira B; Asadourian, Lynda; Del Carmen, Tessa; Friedman, Paula K


    Aging is the physiologic change that occurs over time. In humans, this change occurs at different rates and are related to lifestyle, environment and genetics. It can be challenging to differentiate normal aging from disease. In the oral cavity, with increasing age the teeth demonstrate wearing of the enamel, chipping and fracture lines, and a darker color. The pulp chamber and canals are reduced in size as a result of the deposition of secondary dentin. Coronal or root caries, however, represent disease. A limited amount of periodontal attachment loss occurs in association with aging, usually manifesting as recession on the buccal surface of teeth. Severe periodontitis occurs in 10.5-12% of the population, with the peak incidence being observed at 35-40 years of age. Changes to the mucosal tissue that occur with age include reduced wound-healing capacity. However, environmental factors, such as smoking, dramatically increase the risk of mucosal pathology. Reduced salivary gland function is often seen in association with medication usage, as well as with disorders such as diabetes mellitus. Both medication use and chronic disorders are more common in older adults. Masticatory function is of particular importance for older adults. Maintenance of a nutritionally complete diet is important for avoiding sarcopenia and the frailty syndrome. Successful oral aging is associated with adequate function and comfort. A reduced, but functional, dentition of 20 teeth in occlusion has been proposed as a measure of successful oral aging. Healthy oral aging is important to healthy aging from both biological and social perspectives. PMID:27501493

  12. [Ageing society and laboratory medicine].

    Okabe, H


    An interest in the ageing process has increased greatly with increasing the population of the aged. The goal of this interest is to improve the quality of life(QOL) in the aged. In this paper, the presidential address "Ageing Society and Laboratory Medicine" at the 46th annual meeting of JSCP in Kumamoto'99 was summarized on the important research for ageing in the past decades. The paper presented was age- and gene-related changes, the latent variation of serum constituents and lipids abnormality in the ageing process. Concerning to the definition of reference value of healthy populations and the subjects who had no combined ailments, the reference interval of individuals(intra-personal), followed 5 years categorized by age, sex, and social conditions, gave a narrow range of variation than did a larger mixed populations(inter-personal). The reference intervals set would be a more sensitive reference than is the customary "normal range" for values occurring in inter-personal. Concerning to the study of the relationship between laboratory test and activity of daily living(ADL), the higher serum levels for TP, Alb, Hb, Glu, TC were observed in the higher ADL. The basic research techniques were also evaluated in the paper. The serum lipoperoxides were correlated with serum lipoprotein free radicals which caused atherosclerosis. The higher frequency of cerebral- and myocardial-infarction in the aged were observed in the higher serum LDL-C and lower serum level of arachidonic acid(AA), eicosapentaenoic acid(EPA), and AA/EPA ratio were observed in AMI patients with lower HDL-C groups than the healthy aged. Although Alzheimer(AD)'s disease had a progressive memory loss and immobile dementia and was reported the decrease of acetyltransferase activity in the brain, decrease of serum level of free choline, lyso-phosphatidylcholine, phosphatidylcholine(PC) and sphingomyelin(SM)/PC ratio were observed in spite of keeping normal serum level of SM. The decreased serum levels of

  13. Early Pulsar Observations with LOFAR

    Hessels, Jason; Alexov, Anastasia; Coenen, Thijs; Hassall, Tom; Karastergiou, Aris; Kondratiev, Vlad; Kramer, Michael; van Leeuwen, Joeri; Mol, Jan David; Noutsos, Aris; Weltevrede, Patrick


    This contribution to the proceedings of "A New Golden Age for Radio Astronomy" is simply intended to give some of the highlights from pulsar observations with LOFAR at the time of its official opening: June 12th, 2010. These observations illustrate that, though LOFAR is still under construction and astronomical commissioning, it is already starting to deliver on its promise to revolutionize radio astronomy in the low-frequency regime. These observations also demonstrate how LOFAR has many "next-generation" capabilities, such as wide-field multi-beaming, that will be vital to open a new Golden Age in radio astronomy through the Square Kilometer Array and its precursors.

  14. Les observables

    Bergounioux Gabriel


    jacents ? Au cours de cette table ronde, la question des observables sera interrogée en partant d’une réflexion concernant les études qui se fondent sur l’inventaire empirique des données pour construire leurs analyses (statistique lexicale, Labphon, corpus-guided linguistics, sociolinguistique variationniste, linguistique cognitive… et en allant jusqu’aux théories qui postulent l’existence de formalismes préalables dont les discours et les textes ratifieraient, par l’actualisation et la distribution de leurs occurrences, la pertinence épistémologique.

  15. Healthy Aging -- Sexual Health

    ... address Submit Home > Healthy Aging > Sexual health Healthy Aging This information in Spanish ( en español ) Sexual health ... to discuss with your doctor. Sexual Health and Aging: Keep the Passion Alive (Copyright © Mayo Foundation) - This ...

  16. Administration on Aging

    ... Federal Initiatives Career Opportunities Contact Us Administration on Aging (AoA) The Administration on Aging (AOA) is the ... themselves. Back to top Older Americans Act and Aging Network To meet the diverse needs of the ...

  17. Aging changes in sleep

    ... this page: // Aging changes in sleep To use the sharing features ... cycle is repeated several times during the night. AGING CHANGES With aging, sleep patterns tend to change. ...

  18. The aging male project

    Farid Saad


    Full Text Available With an increasing life expectancy and a decreasing reproduction rate, the population structure changes. A Jenapharm R & D program investigates the endocrinology of aging men. In men, a decrease in production of sex steroids and other hormones with age can be observed. The typical patterns of daily rhythmicity become less distinct. This is part of a very complex picture in which not only isolated hormones are involved, but also the influence of hormones on each other. Many factors from the external and intemal environment mediated by neurotransmitters constantly affect the highly sensitive hormonal balance. Therefore, aging has also been defined as "the gradual dysfunction of homeostatic processes". Declining testosterone (T levels are involved in 'andropausal' symptoms in men: loss of libido, erectile dysfunction, insulin receptor resistance, obesity, osteoporosis, disturbances of lipid metabolism, myocardial and circulatory disturbances, impaired well-being and mood. Data are derived from studies in hypogonadal men treated by T replacement. In such parients under T treatment libido increases, fat mass decreases, muscle strenth, bone mineral density and erythropoesis increase. Whether the symptoms of andropause in aging men could successfully be treated by T substitution remains to be investigated. Negative effects of T, especially on the prostate and the cardiovascular system, are under discussion. There is increasing evidence that low T levels seem to be a risk factor for both the prostate and the cardiovascular system. Jenapharm's new testosterone undecanoate formulation for intramuscular injection can be administered every three months. T levels remain within the physiologic range. No supraphysiologic peaks occur. In women, estrogens have beneficial non-genital effects. Studies concentrate on synthetic estrogens for men without feminizing properties such as gynecomastia and reduced testicular size. Several derivatives of 17-

  19. Photoplethysmogram reflection index and aging

    Qawqzeh, Yousef K.; Reaz, M. B. I.; Maskon, O.; Chellappan, Kalaivani; Ali, M. A. M.


    This study conducted to investigate and study the effect of aging on Photoplethysmogram (PPG) signal and the effects of aging on the calculations of reflection index (RI). The results showed that PPG is highly affected by aging which noteworthy to be observed by the variations of PPG contour. Since we advance in age, PPG becomes more rounded which in turn make PPG inflection point and dicrotic notch less pronounced. As a conclusion, RI may provide a window to small and medium arteries compliance and it can be a measure of small and medium arteries stiffness. When small and medium arteries start stiffening, early detection of atherosclerosis in sub-clinical settings can be investigated and detected.

  20. Observe Your Shadow

    Rovšek, Barbara


    Observe Your Shadow was the title of an observational experiment that was, among others, conducted in the scope of the past year's (2014-2015) first Slovene science competition for elementary school pupils between the ages of 6 and 13. The main reason for establishing a new science competition was popularization of science and its experimental methods, particularly among elementary school students. Elementary school teachers are not generally specialists in science, but rather have (and should have) extremely wide scopes of interests and competencies. By providing them with ideas and instructions for science experiments, we aim to enrich regular school lessons. In the first year alone, the competition took place in over half of Slovene elementary schools, with a total of 9000 participating students. In this paper we shall report about pupils' responses to tasks related to one of the experiments, namely, observation of their shadows on a sunny day.

  1. Practical pathology of aging mice

    Piper M. M. Treuting


    Full Text Available Old mice will have a subset of lesions as part of the progressive decline in organ function that defines aging. External and palpable lesions will be noted by the research, husbandry, or veterinary staff during testing, cage changing, or physical exams. While these readily observable lesions may cause alarm, not all cause undue distress or are life-threatening. In aging research, mice are maintained until near end of life that, depending on strain and genetic manipulation, can be upwards of 33 months. Aging research has unique welfare issues related to age-related decline, debilitation, fragility, and associated pain of chronic diseases. An effective aging research program includes the collaboration and education of the research, husbandry, and veterinary staff, and of the members of the institution animal care and use committee. This collaborative effort is critical to humanely maintaining older mice and preventing excessive censorship due to non-lethal diseases. Part of the educational process is becoming familiar with how old mice appear clinically, at necropsy and histopathologically. This baseline knowledge is important in making the determination of humane end points, defining health span, contributing causes of death and effects of interventions. The goal of this paper is to introduce investigators to age-associated diseases and lesion patterns in mice from clinical presentation to pathologic assessment. To do so, we present and illustrate the common clinical appearances, necropsy and histopathological lesions seen in subsets of the aging colonies maintained at the University of Washington.

  2. Age-related skin changes

    Božanić Snežana


    Full Text Available Age-related skin changes can be induced by chronological ageing, manifested in subcutaneous fat reduction, and photo-ageing eliciting increased elastotic substance in the upper dermis, destruction of its fibrilar structure, augmented intercellular substance and moderate inflammatory infiltrate. Forty-five biopsy skin samples of the sun-exposed and sun-protected skin were analyzed. The patients were both males and females, aged from 17 to 81 years. The thickness of the epidermal layers and the number of cellular living layers is greater in younger skin. The amount of keratohyaline granules is enlarged in older skin. Dermoepidermal junction is flattened and the presence of elastotic material in the dermis is pronounced with age. The amount of inflammatory infiltrate is increased, the fibrous trabeculae are thickened in older skin and the atrophy of the hypodermis is observed. Chronological ageing alters the fibroblasts metabolism by reducing their life span, capacity to divide and produce collagen. During ageing, the enlargement of collagen fibrils diminishes the skin elasticity.

  3. Mitochondria and the aging heart

    Ketul R Chaudhary; Haitham El-Sikhry; John M Seubert


    The average human life span has markedly increased in modern society largely attributed to advances in medical and therapeutic sciences that have successfully reduced important health risks.However,advanced age results in numerous alterations to cellular and subcellular components that can impact the overall health and function of an individual.Not surprisingly,advanced age is a major risk factor for the development of heart disease in which elderly populations observe increased morbidity and mortality.Even healthy individuals that appear to have normal heart fimction under resting conditions,actually have an increased susceptibility and vulnerability to stress.This is confounded by the impact that stress and disease can have over time to both the heart and vessels. Although, there is a rapidly growing body of literature investigating the effects of aging on the heart and how age-related alterations affect cardiac fimction, the biology of aging and underlying mechanisms remain unclear .In this review,we summarize effects of aging on the heart and discuss potential theories of cellular aging with special emphasis on mitochondrial dysfunction.

  4. Spectral ageing a new age perspective

    Rawlings, S; Rawlings, Katherine M Blundell & Steve


    We present an up-to-date critique of the physical basis for the spectral ageing method. We find that the number of cases where this method may be meaningfully applied to deduce the ages of classical double radio sources is small indeed. This critique is much more than merely a re-expression of anxieties about the calibration of spectral ageing (which have been articulated by others in the past).

  5. New concept of age(ing: Prospective age

    Devedžić Mirjana


    Full Text Available While the last century was the century of world population growth, according to demographers, the XXI century will be century of population aging. Statistics undoubtedly show that number of elderly will continue it’s growth in the future. If old age is seen as period of life with reduced physical and mental capabilities and increased disability, and demographic aging as increase of dependent population, trends are quite disturbing, at least in certain societal segments. In developed countries, this population category is no longer treated as passive or as a "burden of society" and efforts are made for better social inclusion of older people. In contrast to growing interest in this phenomenon, the concepts that define the aging of the population remained stagnant. The aim of this paper is to introduce into domestic literature the term "prospective age" as a dynamic category which is more affected with socio-historical conditions, not only with biological as traditional definition of aging suggested. Papers written by Sanderson and Scherbov offer new methodological options for study of population aging, because it takes into account the biometric rather than chronological approach. Calculation of prospective years is a simple operation that requires pair of the same number of remained life expectancy from life tables for two different periods (the year of concern is index, and the one we are comparing with is standard year, so that phrase "40s is the new 30s" or "70s the new 60s" gets scientific foundation. Average remaining years of life represent a realistic indicator suggesting increased capacity, activity and vitality of individuals, which is due to accepted demographic parameters still considered old. „Prospective threshold“ is defined as the age when life expectancy falls below 15 years (it is subjective choice made by Sanderson and Scherbov, which is also used in this paper and during the elaboration of these ideas three demographic

  6. Observational exobiology

    Tarter, J.


    The Earth's atmosphere absorbs partially or completely many ultraviolet, infrared and submillimeter wavelengths. Atmospheric seeing distorts small images, imposing a limit on the achievable angular resolution at optical and infrared wavelengths that is much poorer than the intrinsic capability of telescope optics. The atomic and molecular species of the atmosphere confuse or prevent the spectral studies of similar compounds outside of the terrestrial environment. Telescopes placed in orbit above the atmosphere avoid these problems and enjoy a unique view of the universe. There are many complex questions pertaining to the origin and evolution of the biogenic elements and compounds and the existence of terrestrial types of planets elsewhere that can be only tackled from orbiting facilities. The detailed nature of the spacecraft, platforms and instrumentation most likely to be launched by the United States and Europe in the near future in an attempt to determine what observational programs would be tractable and which areas of interest to exobiology required hardware capabilities beyond those currently envisioned are considered.

  7. Observing the stars. Love in the age of systems

    Kjetil Ansgar Jakobsen


    Full Text Available A number of scholars have demonstrated how the cultural industry involves people in a participatory culture in which users actively construct personal identities. However, the link between a public of mass-mediated entertainment and the private sphere of intimacy and personal identity is a paradox. A consistent theory to clarify that paradox is lacking in the cultural studies literature. I suggest that social systems theory in the Luhmannian tradition may explain in economical terms why the continuous performance and intensification of the paradox of mass-mediated intimacy is a major trait of contemporary culture. Nevertheless, the article does not address normative issues. It is neither an apology for the culture industry, nor a condemnation. The aim is simply to bring one of the most powerful tools of analysis in social theory today to bear on an aspect of modern society which is as important as it is baffling.

  8. Careveillance of Aging Bodies As Proxemic Diffraction

    Lutz, Peter


    New healthcare technologies are increasingly used for augmenting old age homecare. These are often designed to improve risk awareness and render healthcare data more visible and mobile. At the same time this situation raises questions about how human-technological relationalities effect old age h...... aging bodies are observed and treated as cared entities. On a final note the article also suggests that the concept ‘proxemic diffraction' provides polycentric vantage points for considering the relational effects of ethnographic inquiry....

  9. Aging of gaseous detectors

    This paper makes an overview of developments in the wire chamber aging field since the wire chamber aging workshop held at the Lawrence Berkeley Laboratory, Berkeley, California on January 16--17, 1986. The author discusses new techniques to analyze the gas impurities and the wire aging products, wire ''nonaging'' in clean systems, wire aging in systems containing various impurities, various examples of problems which can ''prime'' surfaces prior to the occurrence of the aging, and some recent aging experience with the ''SSC micro-straw tubes.'' 35 refs., 10 figs., 2 tabs

  10. Radiation and aging

    Dorsal root ganglia (DRG) specimens were obtained from 3 women aged in their 6th decade and 5 men in their 8th decade, who were exposed to A-bomb at ≤ 3,000 m from the hypocenter in Nagasaki, and were analyzed for the frequency of DRG neurons with lipofuscin (LP), neuromelanin (NM), and eosinophilic granule (EG). The neurons for the men in the A-bomb group showed an increase of LP and a decrease of NM compared with those in age- and sex-matched control group, with significant differences (p < 0.05 and p < 0.01). The frequency of neurons with EG tended to be slightly higher for the men in the A-bomb group than in the control group; however, this was not statistically significant. For the women, there was a tendency toward a higher frequency of neurons with LP in the A-bomb group than in the control group, although no statistically significant difference emerged from this limited material. Regarding NM and EG for the women, DRG neurons showed no significant difference between the groups. Both men and women showed similar trends for the frequency of DRG neurons without pigments; no significant difference was observed between the groups. Regarding the sum of DRG neurons with large amounts of LP and with mixed LP and EG, the frequency of neurons was significantly higher for the men in the A-bomb group than in the control group, although this was not significant for the women. (Namekawa, K.)

  11. Visual Signs of Ageing

    Helle Rexbye


    Full Text Available Consumer culture has placed the ageing body in a dilemma of representation. Physical appearance has become increasingly important as a symbol of identity, and at the same time society idealizes youth. This study explores visual ageing empirically. By using photographs of older persons (70+ as starting point, it is explored how visual age is assessed and interpreted. It is shown that informants read age in a spread of stages and categories. Main age indicators are biological markers: skin, eyes, and hair colour, but supplemented by vigour, style, and grooming. Furthermore, in-depth interviews indicate that visual age is mainly interpreted into categories and moral regulations rooted in early modernity. Subsequently the question of a postmodern perspective of visual ageing is discussed in this article. The empirical findings in the study question a postmodern fluidity of visual signs – at least when the concern is signs of ageing.

  12. National Institute on Aging

    ... Join Our Mailing List Email The Leader in Aging Research NIA, one of the 27 Institutes and ... broad scientific effort to understand the nature of aging and to extend the healthy, active years of ...

  13. Aging changes in immunity

    ... cells and antibodies that destroy these harmful substances. Aging Changes and Their Effects on the Immune System ... Prevention To decrease the risks from immune system aging: Get the flu and pneumonia vaccines, and any ...

  14. NIA Aging Cell Repository

    Federal Laboratory Consortium — To facilitate aging research on cells in culture, the NIA provides support for the NIA Aging Cell Repository, located at the Coriell Institute for Medical Research...

  15. Corrected Age for Preemies

    ... Prenatal Baby Bathing & Skin Care Breastfeeding Crying & Colic Diapers & Clothing Feeding & Nutrition Preemie Sleep Teething & Tooth Care Toddler Preschool Gradeschool Teen Young Adult Healthy Children > Ages & Stages > Baby > Preemie > Corrected Age ...

  16. Alaska Radiometric Ages

    U.S. Geological Survey, Department of the Interior — The Alaska Radiometric Age file is a database of radiometric ages of rocks or minerals sampled from Alaska. The data was collected from professional publications...

  17. Aging changes in immunity

    ... this page: // Aging changes in immunity To use the sharing features ... cells and antibodies that destroy these harmful substances. Aging Changes and Their Effects on the Immune System ...

  18. Memory and Aging

    Memory and Aging Losing keys, misplacing a wallet, or forgetting someone’s name are common experiences. But for people nearing or over age 65, such memory lapses can be frightening. They wonder if they ...

  19. Components of aging

    Wiegand, Iris


    Age-related cognitive decline has been linked to a reduction in attentional resources that are assumed to result from alterations in the aging brain. A core ability that is subject to age-related decline is visual attention, which enables individuals to select the most important information for conscious processing and action. However, visual attention is considered a conglomerate of various functions and the specific components underlying age differences in performance remain little understo...

  20. The Gestational Age Pattern of Human Mortality

    Schöley, Jonas; Vaupel, James W.; Jacobsen, Rune;


    a "birth hump" peaking week 38. The absolute rate of decline slows down over age. The observed gestational age pattern of the force of mortality is consistent with three hypotheses concerning the causes for ontogenescense: 1) Adaptation: as the organism growths it becomes more resilient towards...... processes I fit a three component mortality model against the observed force of mortality. The model describes the data with high accuracy, suggesting that the phenomenon of ontogenescense in humans is fully explained by the three hypotheses....

  1. Viewing Our Aged Selves: Age Progression Simulations Increase Young Adults' Aging Anxiety and Negative Stereotypes of Older Adults.

    Rittenour, Christine E; Cohen, Elizabeth L


    This experiment tests the effect of an old-age progression simulation on young adults' (N = 139) reported aging anxiety and perceptions about older adults as a social group. College students were randomly assigned to one of three conditions: self-aged simulation, stranger-aged simulation, or a control group. Compared with the control group, groups exposed to an age progression experienced more negative affect, and individuals in the self-aged condition reported greater aging anxiety. In accordance with stereotype activation theorizing, the self-age simulation group also perceived older adults as less competent and expressed more pity and less envy for older adults. Compared to the stranger-aged group, participants who observed their own age progression were also the more likely to deny the authenticity of their transformed image.These findings highlight potential negative social and psychological consequences of using age simulations to affect positive health outcomes, and they shed light on how virtual experiences can affect stereotyping of older adults. PMID:27076488

  2. Optimal Aging and Death

    Dalgaard, Carl-Johan; Strulik, Holger

    representative consumer is subject to physiological aging. In modeling aging we draw on recent research in the fields of biology and medicine. The speed of the aging process, and thus the time of death, are endogenously determined by optimal health investments. We calibrate the model to US data and proceed to...

  3. Optimal Aging and Death

    Dalgaard, Carl-Johan Lars; Strulik, Holger


    This study introduces physiological aging into a simple model of optimal intertemporal consumption. In this endeavor we draw on the natural science literature on aging. According to the purposed theory, the speed of the aging process and the time of death are endogenously determined by optimal...

  4. Age and Farmer Productivity

    Tauer, Loren W.


    Farmer productivity by age was estimated, allowing for differences because of efficiency and returns to scale. Using Census of Agriculture data, estimates vary by state, but returns to scale average 1.07. Efficiency increases average 4.5 percent every ten years of age, to the age interval 35 to 44, and then decreases at that same rate.

  5. Peroxisomes in yeast ageing

    Kumar, Sanjeev


    Ageing is characterized by the progressive decline in cellular functions that eventually leads to death. In human, ageing is associated with several age-related diseases such as cancer, cardiovascular disorders and neurodegenerative diseases. Over the years, research performed in several simpler sho

  6. PerformAge

    Fristrup, Tine


    ), I do not want to paint a uniformly rosy picture of aging and old age, but unfold an opening up of life taking the heroines and heroes of aging life to the open road in search of themselves and new roles in life as a quest of self-knowledge, self-development – a role for the future. Different...

  7. Hodgkin's disease and age

    Specht, L.; Nissen, N.I.


    modality, stage, and total tumour burden, whereas age had no prognostic significance. With regard to death from Hodgkin's disease only age and total tumour burden had independent significance. The significance of age would seem to stem from the fact that some older patients could not be given adequate...

  8. Osteoclasts prefer aged bone

    Henriksen, K; Leeming, Diana Julie; Byrjalsen, I;


    We investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts preferentially develop and resorb bone on aged bone. These findings indicate that the bone matrix itself plays a role in targeted remodeling of...... aged bones....

  9. Filter-adsorber aging assessment

    An aging assessment of high-efficiency particulate (HEPA) air filters and activated carbon gas adsorption units was performed by the Pacific Northwest Laboratory as part of the U.S. Nuclear Regulatory Commission's (USNRC) Nuclear Plant Aging Research (NPAR) Program. This evaluation of the general process in which characteristics of these two components gradually change with time or use included the compilation of information concerning failure experience, stressors, aging mechanisms and effects, and inspection, surveillance, and monitoring methods (ISMM). Stressors, the agents or stimuli that can produce aging degradation, include heat, radiation, volatile contaminants, and even normal concentrations of aerosol particles and gasses. In an experimental evaluation of degradation in terms of the tensile breaking strength of aged filter media specimens, over forty percent of the samples did not meet specifications for new material. Chemical and physical reactions can gradually embrittle sealants and gaskets as well as filter media. Mechanisms that can lead to impaired adsorber performance are associated with the loss of potentially available active sites as a result of the exposure of the carbon to airborne moisture or volatile organic compounds. Inspection, surveillance, and monitoring methods have been established to observe filter pressure drop buildup, check HEPA filters and adsorbers for bypass, and determine the retention effectiveness of aged carbon. These evaluations of installed filters do not reveal degradation in terms of reduced media strength but that under normal conditions aged media can continue to effectively retain particles. However, this degradation may be important when considering the likelihood of moisture, steam, and higher particle loadings during severe accidents and the fact it is probable that the filters have been in use for an extended period

  10. Aging fingerprints in combustion particles

    V. Zelenay


    Full Text Available Soot particles can significantly influence the Earth's climate by absorbing and scattering solar radiation as well as by acting as cloud condensation nuclei. However, despite their environmental (as well as economic and political importance, the way these properties are affected by atmospheric processing is still a subject of discussion. In this work, soot particles emitted from two different cars, a EURO 2 transporter, a EURO 3 passenger vehicle, and a wood stove were investigated on a single-particle basis. The emitted exhaust, including the particulate and the gas phase, was processed in a smog chamber with artificial solar radiation. Single particle specimens of both unprocessed and aged soot were characterized using x-ray absorption spectroscopy and scanning electron microscopy. Comparison of the spectra from the unprocessed and aged soot particles revealed changes in the carbon functional group content, such as that of carboxylic carbon, which can be ascribed to both the condensation of secondary organic compounds on the soot particles and oxidation of primary soot particles upon photochemical aging. Changes in the morphology and size of the single soot particles were also observed upon aging. Furthermore, we show that the soot particles take up water in humid environments and that their water uptake capacity increases with photochemical aging.

  11. Ageing Management of CARR

    The paper introduced the ageing management of CARR, including the ageing management system, instances of ageing components, difficulties we met and follow up plan, and put forward some suggestions on strengthening and promoting ageing management. We hope to enhance international exchange and collaboration. It is a great challenge to do research on how to manage ageing effectively in the beginning of life, but it will enhance the safety of reactor operation, extend the life of the reactor and improve the quality of operation, making this work very meaningful

  12. Can aging be 'drugged'?

    Riera, Celine E; Dillin, Andrew


    The engines that drive the complex process of aging are being identified by model-organism research, thereby providing potential targets and rationale for drug studies. Several studies of small molecules have already been completed in animal models with the hope of finding an elixir for aging, with a few compounds showing early promise. What lessons can we learn from drugs currently being tested, and which pitfalls can we avoid in our search for a therapeutic for aging? Finally, we must also ask whether an elixir for aging would be applicable to everyone, or whether we age differently, thus potentially shortening lifespan in some individuals. PMID:26646496

  13. Carcinogenesis and aging

    This 2-voluem set discusses the problem of inter-relation between carcinogenesis and aging, and the phenomenon of age-related increase in cancer incidence in animals and humans. Covered topics include current concepts in mechanisms of carcinogenesis and aging; data on chemical, radiation, ultraviolet-light, hormonal and viral carcinogenesis in aging; data on the role of age-related shifts in the activity of carcinogen-metabolizing enzymes; binding of carcinogens with macromolecules; DNA repair; tissue proliferation; and immunity and homono-metabolic patterns in realization of initiation and promotion of carcinogenesis

  14. Heart Age PSA (:60)


    This 60 second public service announcement is based on the September 2015 CDC Vital Signs report. Your heart age is the age of your heart and blood vessels as a result of your risk factors for heart attack and stroke. If you smoke or have high blood pressure, your heart age will be much higher than your actual age. Learn what you can do to lower your heart age and keep it low.  Created: 9/1/2015 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 9/1/2015.

  15. Wages, productivity and aging

    Dostie, Benoît


    In this article, we estimate age based wage and productivity differentials using linked employer-employee Canadian data from the Workplace and Employee Survey 1999-2003. Data on the firm side is used to estimate production functions taking into account the age profile of the firm's work-force. Data on the workers' side is used to estimate wage equations that also depend on age. Results show concave age-wage and age-productivity profiles. Wage-productivity comparisons show that the productivit...

  16. UV, stress and aging.

    Debacq-Chainiaux, Florence; Leduc, Cedric; Verbeke, Alix; Toussaint, Olivier


    Skin is a model of choice in studies on aging. Indeed, skin aging can be modulated by internal and external factors, reflecting its complexity. Two types of skin aging have been identified: intrinsic, mainly genetically determined and extrinsic-also called "photo-aging"-resulting on the impact of environmental stress and more precisely of UV rays. Simplified in vitro models, based on cellular senescence, have been developed to study the relationship between UV and aging. These models vary on the cell type (fibroblasts or keratinocytes, normal or immortalized) and the type of UV used (UVA or UVB). PMID:23467762

  17. On aging and aged care in Serbia.

    Sevo, G; Davidovic, M; Erceg, P; Despotovic, N; Milosevic, D P; Tasic, M


    Serbia is a demographically old nation, with 17.4 % of its residents being aged 65 years and older in 2011. The previous two decades of turbulent history have significantly affected the demographic picture of this country, and their ramifications remain visible in Serbia's economic, political, cultural, and health spheres. Major demographic forces behind population aging in Serbia can be attributed to lower fertility rates, migrations, and declining mortality (reflecting improvements in overall health leading to a longer life expectancy). In Serbia, low fertility and migrations appear to play major roles, although the relative contribution of recent migrations cannot be measured with accuracy. Patterns of demographic aging vary considerably across different geographic, socioeconomic, and cultural settings. The common denominator throughout present day Serbia is extensive political and economic transition. One would expect that, given sufficient time, this process will result in improved population health, and yet, at this stage outcomes of major health care reform in Serbia are somewhat perplexing. For the second consecutive year, Serbia's health care system has been ranked at the very bottom of the scale among 34 European countries. It is then no surprise that the elderly represent particularly vulnerable population segment. This paper discusses some of the issues relevant to these demographic patterns of aging and aged care in contemporary Serbia, focusing on the period after 2000. PMID:25943380

  18. Aging male syndrome

    Valer Donca


    Full Text Available Aging Male Syndrome is a medical condition through which men could pass between the ages of 35 and 65, when testosterone levelsin their body decline considerably. Androgen deficiency in the aging male has become a topic of increasing interest and debate throughout theworld. In contrast to female menopause, the process of aging in the male genital system is slow and highly variable between individuals. Thecharacteristic symptoms of Aging Male Syndrome include weakness, depression, fatigue and changes in body hair and skin, decreased sexualdesire, decreased lean body mass accompanied by increased visceral fat, decreased bone mineral density. Aging Male Syndrome is usually diagnosedby testing the blood for testosterone levels. The usual treatment method for Aging Male Syndrome includes testosterone injections,testosterone patches, testosterone gels and oral preparations.

  19. Skin mirrors human aging.

    Nikolakis, Georgios; Makrantonaki, Evgenia; Zouboulis, Christos C


    Abstract Aged skin exhibits disturbed lipid barrier, angiogenesis, production of sweat, immune functions, and calcitriol synthesis as well as the tendency towards development of certain benign or malignant diseases. These complex biological processes comprise endogenous and exogenous factors. Ethnicity also markedly influences the phenotype of skin aging. The theories of cellular senescence, telomere shortening and decreased proliferative capacity, mitochondrial DNA single mutations, the inflammation theory, and the free radical theory try to explain the biological background of the global aging process, which is mirrored in the skin. The development of advanced glycation end-products and the declining hormonal levels are major factors influencing intrinsic aging. Chronic photodamage of the skin is the prime factor leading to extrinsic skin aging. The deterioration of important skin functions, due to intrinsic and extrinsic aging, leads to clinical manifestations, which mirror several internal age-associated diseases such as diabetes, arterial hypertension and malignancies. PMID:25436743

  20. CEO age and gender: Subsequent market performance

    Marcelo Eduardo


    Full Text Available The issue of CEO age and gender vs. concurrent performance is extensively examined, but the association with subsequent performance has limited treatment in the financial literature, and with conflicting findings. In the current study, we examine the association between CEO age and gender, and subsequent company market performance using a more recent set of observations and the standard four-factor model to estimate future cumulative abnormal shareholder returns. We find that subsequent abnormal shareholder returns are marginally significantly higher for female CEOs than for their male counterparts, but no material pattern is observed between CEO age and subsequent abnormal shareholder return performance.

  1. VERITAS Observations under Bright Moonlight



    The presence of moonlight is usually a limiting factor for imaging atmospheric Cherenkov telescopes due to the high sensitivity of the camera photomultiplier tubes (PMTs). In their standard configuration, the extra noise limits the sensitivity of the experiment to gamma-ray signals and the higher PMT currents also accelerates PMT aging. Since fall 2012, observations have been carried out with VERITAS under bright moonlight (Moon illumination $> 35\\%$), in two observing modes, by reducing the voltage applied to the PMTs and with UV bandpass filters, which allow observations up to $\\sim80\\%$ Moon illumination resulting in $29\\%$ more observing time over the course of the year. In this presentation, we provide details of these new observing modes and their performance relative to the standard VERITAS observations.

  2. Analyzer of Spectra for Age Determination (ASAD) - Algorithm and Applications

    Asa'd, Randa


    Analyzer of Spectra for Age Determination (ASAD) is a new package that can easily predict the age and reddening of stellar clusters from their observed optical integrated spectra by comparing them to synthesis model spectra. The ages obtained with ASAD are consistent with ages obtained from previous cluster age methods requiring a more rigorous and time-consuming analysis. This package not only provides fast results, but also allows the user to comprehend the accuracy of these results by prov...

  3. Like milk or wine : does firm performance improve with age?

    Coad, Alex; Segarra Blasco, Agustí; Teruel Carrizosa, Mercedes


    Our empirical literature review shows that little is known about how firm performance changes with age, presumably because of the paucity of data on firm age. For Spanish manufacturing firms, we analyse the firm performance related to firm age between 1998 and 2006. We find evidence that firms improve with age, because ageing firms are observed to have steadily increasing levels of productivity, higher profits, larger size, lower debt ratios, and higher equity ratios. Furthermore, older firms...

  4. Autophagy in ageing and ageing-associated diseases

    Li-qiang HE; Jia-hong LU; Zhen-yu YUE


    Autophagy is a cell self-digestion process via lysosomes that clears "cellular waste",including aberrantly modified proteins or protein aggregates and damaged organelles.Therefore,autophagy is considered a protein and organelle quality control mechanism that maintains normal cellular homeostasis.Dysfunctional autophagy has been observed in ageing tissues and several ageing-associated diseases.Lifespan of model organisms such as yeast,worms,flies,and mice can be extended through promoting autophagy,either by genetic manipulations such as over-expression of Sirtuin 1,or by administrations of rapamycin,resveratrol or spermidine.The evidence supports that autophagy may play an important role in delaying ageing or extending lifespan.In this review,we summarize the current knowledge about autophagy and its regulation,outline recent developments ie the genetic and pharmacological manipulations of autophagy that affects the lifespan,and discuss the role of autophagy in the ageing-related diseases.ow in Center for Neurodegenerative and Neuroimmunologic Diseases,Department of Neurology,University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School,Piscataway,NJ 08854,USA

  5. Galactic Globular Cluster Relative Ages. II

    De Angeli, F; Cassisi, S; Busso, G; Recio-Blanco, A; Salaris, M; Aparicio, A; Rosenberg, A L


    We present accurate relative ages for a sample of 55 Galactic globular clusters. The ages have been obtained by measuring the difference between the horizontal branch and the turnoff in two, internally photometrically homogeneous databases. The mutual consistency of the two data sets has been assessed by comparing the ages of 16 globular clusters in common between the two databases. We have also investigated the consistency of our relative age determination within the recent stellar model framework. All clusters with [Fe/H]-0.8 are ~1 Gyr younger than the most metal poor ones, with a relatively small age dispersion, though the metal rich sample is still too small to allow firmer conclusions. There is no correlation of the cluster age with the Galactocentric distance. We briefly discuss the implication of these observational results for the formation history of the Galaxy.

  6. Healthy Aging in China

    Smith, James P.; Strauss, John; Zhao, Yaohui


    China has aged rapidly and the rate is accelerating in decades to come. We review positive and negative forces for healthy aging in China now and in the future. The most positive force is the spectacular growth in education over time especially for Chinese women, which should improve all dimensions of cognitive and physical health and eliminate vast gender disparities in healthy aging that currently exist.

  7. The aging lung

    Lowery EM


    Full Text Available Erin M Lowery,1 Aleah L Brubaker,2 Erica Kuhlmann,1 Elizabeth J Kovacs31Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine at Loyola University Medical Center, 2Loyola University Stritch School of Medicine, 3Department of Surgery, Loyola University Medical Center, Maywood, IL, USAAbstract: There are many age-associated changes in the respiratory and pulmonary immune system. These changes include decreases in the volume of the thoracic cavity, reduced lung volumes, and alterations in the muscles that aid respiration. Muscle function on a cellular level in the aging population is less efficient. The elderly population has less pulmonary reserve, and cough strength is decreased in the elderly population due to anatomic changes and muscle atrophy. Clearance of particles from the lung through the mucociliary elevator is decreased and associated with ciliary dysfunction. Many complex changes in immunity with aging contribute to increased susceptibility to infections including a less robust immune response from both the innate and adaptive immune systems. Considering all of these age-related changes to the lungs, pulmonary disease has significant consequences for the aging population. Chronic lower respiratory tract disease is the third leading cause of death in people aged 65 years and older. With a large and growing aging population, it is critical to understand how the body changes with age and how this impacts the entire respiratory system. Understanding the aging process in the lung is necessary in order to provide optimal care to our aging population. This review focuses on the nonpathologic aging process in the lung, including structural changes, changes in muscle function, and pulmonary immunologic function, with special consideration of obstructive lung disease in the elderly.Keywords: aging, lung, pulmonary immunology, COPD

  8. Aging and cosmetic enhancement

    Honigman, Roberta; David J. Castle


    Obsession with a youthful appearance has become commonplace in modern society and has resulted in an upswing in cosmetic procedures trying to reverse the aging process. We selectively review the literature on aging and cosmetic surgery, with particular regard for the aging face. We pay attention to psychosocial aspects of response to such cosmetic procedures, both in terms of outcome and with respect to risk factors for a poor outcome.

  9. We Are Ageing

    Kolovou, Genovefa D; Kolovou, Vana; Mavrogeni, Sophie


    Ageing and longevity is unquestioningly complex. Several thoughts and mechanisms of ageing such as pathways involved in oxidative stress, lipid and glucose metabolism, inflammation, DNA damage and repair, growth hormone axis and insulin-like growth factor (GH/IGF), and environmental exposure have been proposed. Also, some theories of ageing were introduced. To date, the most promising leads for longevity are caloric restriction, particularly target of rapamycin (TOR), sirtuins, hexarelin and ...

  10. Optimal Aging and Death

    Dalgaard, Carl-Johan Lars; Strulik, Holger


    This study introduces physiological aging into a simple model of optimal intertemporal consumption. In this endeavor we draw on the natural science literature on aging. According to the purposed theory, the speed of the aging process and the time of death are endogenously determined by optimal...... health investments. At the same time, physiological aspects of the aging process influence optimal savings and health investment. We calibrate the model for the average US male in 2000 and proceed to show that the calibrated model accounts well for the cross-country link between labor productivity and...

  11. Age, wage and productivity

    van Ours, J.C.; Stoeldraijer, L.


    Previous empirical studies on the effect of age on productivity and wages find contradicting results. Some studies find that if workers grow older there is an increasing gap between productivity and wages, i.e. wages increase with age while productivity does not or does not increase at the same pace. However, other studies find no evidence of such an age related pay-productivity gap. We perform an analysis of the relationship between age, wage and productivity using a matched worker-firm pane...

  12. Hodgkin's disease and age

    Specht, L; Nissen, N I


    506 unselected, previously untreated patients with Hodgkin's disease were treated at the Finsen Institute between 1969 and 1983. The prognostic significance of age, sex, stage, systemic symptoms, histologic subtype, number of involved nodal regions, total tumour burden (peripheral + intrathoracic...... modality, stage, and total tumour burden, whereas age had no prognostic significance. With regard to death from Hodgkin's disease only age and total tumour burden had independent significance. The significance of age would seem to stem from the fact that some older patients could not be given adequate...

  13. Nutrients, Microglia Aging, and Brain Aging

    Zhou Wu; Janchun Yu; Aiqin Zhu; Hiroshi Nakanishi


    As the life expectancy continues to increase, the cognitive decline associated with Alzheimer’s disease (AD) becomes a big major issue in the world. After cellular activation upon systemic inflammation, microglia, the resident immune cells in the brain, start to release proinflammatory mediators to trigger neuroinflammation. We have found that chronic systemic inflammatory challenges induce differential age-dependent microglial responses, which are in line with the impairment of learning and ...

  14. On aging factors, aging mechanisms and their combinations in the primary circuit of NPPs

    Ageing is the dominating problem of elder nuclear power plant (NPP) components but still can not be neglected even for the newest ones. Ageing may express itself in different ways: irradiated steel parts may become embrittled, chromium alloy steels may decompose, fatigue life may become exhausted so that cracks may be formed and finally, corrosion attack may result in stress corrosion cracking. However, even synthetics and rubber parts may become inelastic, swell, shrink or crack, electric contacts may be oxydised, or isolations may lose their high electric resistance. Therefore, experts in the different components and their materials have collected and published not only plenty of observations, but also a number of more or less systematic approaches. A general picture, however, still seems to be lacking, due to the fact that ageing factors and mechanisms are not defined and used properly, i.e. - ageing factors act because of the service conditions of the components, as well as the characteristics of the materials which provoke ageing mechanisms - ageing mechanisms cause the changing of properties of the materials involved - combinations of single ageing mechanisms, which can be double, triple or multiple, change and accelerate the ageing process - the consequence of ageing mechanisms is the altering of the properties of the material depending on the lifetime. In this paper we shall try to show a systematic approach to a potential ageing analysis concerning the main metallic components of primary circuits of NPP's - connection between ageing factors, ageing mechanisms and their consequences/effects on component behaviour

  15. Characterising the pollutant ventilation characteristics of street canyons using the tracer age and age spectrum

    Lo, K. W.; Ngan, K.


    The age of air, which measures the time elapsed between the emission of a chemical constituent and its arrival at a receptor location, has many applications in urban air quality. Typically it has been estimated for special cases, e.g. the local mean age of air for a spatially homogeneous source. An alternative approach uses the response to a point source to determine the distribution of transit times or tracer ages connecting the source and receptor. The distribution (age spectrum) and first moment (mean tracer age) have proven to be useful diagnostics in stratospheric modelling because they can be related to observations and do not require a priori assumptions. The tracer age and age spectrum are applied to the pollutant ventilation of street canyons in this work. Using large-eddy simulations of flow over a single isolated canyon and an uneven, non-uniform canyon array, it is shown that the structure of the tracer age is dominated by the central canyon "vortex"; small variations in the building height have a significant influence on the structure of the tracer age and the pollutant ventilation. The age spectrum is broad, with a long exponential tail whose slope depends on the canyon geometry. The mean tracer age, which roughly characterises the ventilation strength, is much greater than the local mean age of air.

  16. Mars Ice Age, Simulated


    December 17, 2003This simulated view shows Mars as it might have appeared during the height of a possible ice age in geologically recent time.Of all Solar System planets, Mars has the climate most like that of Earth. Both are sensitive to small changes in orbit and tilt. During a period about 2.1 million to 400,000 years ago, increased tilt of Mars' rotational axis caused increased solar heating at the poles. A new study using observations from NASA's Mars Global Surveyor and Mars Odyssey orbiters concludes that this polar warming caused mobilization of water vapor and dust into the atmosphere, and buildup of a surface deposit of ice and dust down to about 30 degrees latitude in both hemispheres. That is the equivalent of the southern Unites States or Saudi Arabia on Earth. Mars has been in an interglacial period characterized by less axial tilt for about the last 300,000 years. The ice-rich surface deposit has been degrading in the latitude zone of 30 degrees to 60 degrees as water-ice returns to the poles.In this illustration prepared for the December 18, 2003, cover of the journal Nature, the simulated surface deposit is superposed on a topography map based on altitude measurements by Global Surveyor and images from NASA's Viking orbiters of the 1970s.Mars Global Surveyor and Mars Odyssey are managed by NASA's Jet Propulsion Laboratory, a division of the California Institute of Technology, Pasadena, for the NASA Office of Space Science, Washington.

  17. Biodemography of human ageing

    Vaupel, James W


    Human senescence has been delayed by a decade. This finding, documented in 1994 and bolstered since, is a fundamental discovery about the biology of human ageing, and one with profound implications for individuals, society and the economy. Remarkably, the rate of deterioration with age seems to be...

  18. Aging, Trade, and Migration

    Chisik, Richard; Onder, Harun; Qirjo, Dhimitri


    This study considers the role of demand-driven changes arising from population aging and how they affect the pattern of international trade as well as trade and immigration policy. An aging society can see a welfare-reducing reduction in its share of manufacturing output and this reduction is magnified by a decrease in trade costs (an increase in globalization). Immigration can ameliorate ...

  19. Biology of ageing

    Rattan, Suresh


    Living systems owe their survival and health to a series of complex biochemical pathways of maintenance and repair. These defense systems create the homeodynamic space of an individual, which is characterized by stress tolerance, molecular damage control and continuous remodeling. Ageing, age-rel...

  20. Healthy ageing through music

    Perkins, Rosie; Bisschop Boele, E.H.; Smilde, Rineke


    Presentation in session ‘Healthy Ageing through Music’. Presentations: - Rineke Smilde: Music and Dementia - Evert Bisschop Boele: Creative Workshops with the Elderly - Rosie Burt-Perkins: Healthy ageing through instrumental music learning World Conference ISME, Thessaloniki, Greece, 20/7/2012

  1. The ageing spine

    This book contain 15 selections. Some of the titles are: Effects of age on the appearance of magnetic resonance images of the spine; Potential for image analysis in quantitative magnetic resonance imaging of the aging spine; Potential of x-ray diffraction computed tomography for discriminating between normal and osteoporotic bone; and Spinal fusion in the elderly

  2. The age of Schumpeter

    Giersch, Herbert


    The centenary of Schumpeter's birth coincides with a revival of Schumpeterian economics. Could the third quarter of this Century justly be called the age of Keynes (Hicks, 1974), the fourth quarter has a fair chance of becoming the age of Schumpeter. Before giving substance to this proposition, I shall present a Short introduction to Schumpeter's life, work and paradigm.

  3. Age, Wage and Productivity

    van Ours, J.C.; Stoeldraijer, L.


    Previous empirical studies on the effect of age on productivity and wages find contradicting results. Some studies find that if workers grow older there is an increasing gap between productivity and wages, i.e. wages increase with age while productivity does not or does not increase at the same pace

  4. A Respectable Old Age.

    Swensen, Clifford H.


    Contrasts the relatively abundant information on the young with the paucity of research knowledge on the aged, and asserts that psychologists have too few solutions to coping with the problems of aging. Suggests the integration of older adults into all aspects of society through structural change. (Author/AOS)

  5. Aging, longevity and health

    Rasmussen, Lene Juel; Sander, Miriam; Wewer, Ulla M.;


    Session included speeches by Ralf Hemmingsen, Ulla Wewer, and Lene Juel Rasmussen and Keynote Addresses by four world renowned aging researchers: Povl Riis (The Age Forum), Bernard Jeune (University of Southern Denmark), George Martin (University of Washington, USA) and Jan Vijg (Albert Einstein School of...

  6. COOEE bitumen: chemical aging

    Lemarchand, Claire A; Dyre, Jeppe C; Hansen, Jesper S


    We study chemical aging in "COOEE bitumen" using molecular dynamic simulations. The model bitumen is composed of four realistic molecule types: saturated hydrocarbon, resinous oil, resin, and asphaltene. The aging reaction is modelled by the chemical reaction: "2 resins $\\rightarrow$ 1 asphaltene". Molecular dynamic simulations of four bitumen compositions, obtained by a repeated application of the aging reaction, are performed. The stress autocorrelation function, the fluid structure, the rotational dynamics of the plane aromatic molecules, and the diffusivity of each molecule, are determined for the four different compositions. The aging reaction causes a significant dynamics slowdown, which is correlated to the aggregation of asphaltene molecules in larger and dynamically slower nanoaggregates. Finally, a detailed description of the role of each molecule types in the aggregation and aging processes is given.

  7. Parylene C Aging Studies.

    Achyuthan, Komandoor; Sawyer, Patricia Sue.; Mata, Guillermo Adrian; White II, Gregory Von; Bernstein, Robert


    Parylene C is used in a device because of its conformable deposition and other advantages. Techniques to study Parylene C aging were developed, and %22lessons learned%22 that could be utilized for future studies are the result of this initial study. Differential Scanning Calorimetry yielded temperature ranges for Parylene C aging as well as post-deposition treatment. Post-deposition techniques are suggested to improve Parylene C performance. Sample preparation was critical to aging regimen. Short-term (~40 days) aging experiments with free standing and ceramic-supported Parylene C films highlighted %22lessons learned%22 which stressed further investigations in order to refine sample preparation (film thickness, single sided uniform coating, machine versus laser cutting, annealing time, temperature) and testing issues (%22necking%22) for robust accelerated aging of Parylene C.

  8. Snubber aging assessment

    Snubbers are safety-related devices used to restrain undesirable dynamic loads at various piping and equipment locations in nuclear power plants (NPPs). Each snubber must accommodate a plant's normal thermal movements and be capable of restraining the maximum off-normal dynamic loads postulated for its specific location. The effects of snubber aging and the environments and mechanisms that degrade snubber performance need to be better understood. This paper describes the Phase II Nuclear Plant Aging Research Program in-plant aging research conducted to enhance the understanding of snubber aging and its consequences. Pacific Northwest Laboratory staff and their subcontractors, Lake Engineering and Wyle Laboratories, visited eight sites (encompassing thirteen plants) to conduct interviews with NPP staff and to collet snubber aging, testing, and maintenance data. The research methodology, evaluations, results, conclusions, and recommendations are described in the paper. Effective methods for service-life monitoring of snubbers are included in the recommendations. (orig.)

  9. Gene and Aging

    DD Farhud


    Full Text Available "nCollection of multiple processes that increase the chronological age of an organism leading to death is defined as aging, and even though important, it is poorly understood. Recent research has shown that aging is due to biochemical and genetic changes, in interaction with environmental effects, including diet and nutrition. Most knowledge on aging is based on ge­netic model system, but its molecular mechanisms are still not very clear. Discoveries in molecular biology have made way to look for candidate genes influencing lifespan. Furthermore, new investigations have stressed on the roles of mitochondria as the major generators and direct targets of reactive oxygen species. This paper reviews some recent literature on genes and ag­ing in model system, then discusses the role of mitochondria and nutrients in human aging.

  10. Overview of facial aging.

    Beer, Kenneth; Beer, Jacob


    Facial aging is a multidimensional, multifactorial process. The aging face has traditionally been treated by each specialty in a different manner. However, by understanding the process from the perspective of different specialties, each physician may better treat the spectrum of facial aging. Whether or not the facial plastic surgeon injects products to restore volume, uses lasers to resurface the epidermis and dermis, incorporates cosmeceuticals to enhance and maintain improvements in the skin integrity and appearance, or relaxes muscles with botulinum toxins, he or she can best advise patients and address facial aging by having a functional understanding of these various modalities. With this knowledge, the facial plastic surgeon can parse the component of facial aging that enables him or her to correct each with the appropriate treatment. PMID:20024868

  11. Ageing and Health: A Health Profile of Inmates of Old Age Home

    Bindu M Bhatt, Shivani Vyas, Janak P Joshi


    Conclusion: It is observed that majority of inmates were suffering from health problems associated with ageing. The elderly comprise a very important vulnerable group is ignored but needs urgent attention.

  12. The period-age relation for cepheids

    The list of 119 cepheid-members of 55 clusters and associations of the Magellanic Clouds, the Galaxy, and M31 is given. The period-age relation is found from the data on 64 cepheids in 29 clusters for which the age determinations are available, the ages of extragalactic clusters were determined mainly from their integral colours. The U-B colours are found to be of much better age parameters than the B-V ones. The composite period-age relation agrees well with the theoretical one. The observed dispersion of the period-age relation leads to an estimate of the age dispersion about 1x107 years in the associations. Some peculiarities of the cepheids with the shortest periods amongst others in the same clusters are probably explained if they are overtone pulsators. The period-age relation may be used for an investigation of the recent history of star formation in the galaxies. This relation allows to determine the age gradient across the spiral arm in M31 which is in agreement with the density wave theory predictions. The distribution of cepheids in our Galaxy and neighbouring galaxies is consistent with the conception of star formation lasting for some dozen million years in cells with a dimension of some hundreds of parsecs

  13. Aging, mitochondria and male reproductive function.

    Amaral, Sandra; Ramalho-Santos, João


    The rise in life expectancy over the last century, together with higher maternal and paternal ages and have highlighted the issue of reduced fertility with advancing age. Aging of the male reproductive system is incited by multi-factorial changes at molecular, cellular and regulatory levels, and individual characteristics are highly variable, although strongly influenced by lifestyle and environmental factors. Damage accumulated with age leads to progressive deregulation of the hypothalamic-pituitary-gonadal axis and of local auto/paracrine interactions, thereby inducing changes in target organs such as the testis, penis and prostate. Elderly human males produce less testosterone, have fewer motile sperm and a higher incidence of erectile dysfunction and prostate disorders, all of which contribute to lower fertility. Cellular aging can manifest itself at several levels. Aging cells progressively accumulate "waste" products, resulting in a decreased functionally. Changes to mitochondria are among the most remarkable features observed in aging cells and several theories place mitochondria at the hub of cellular events related to aging, namely in terms of the accumulation of oxidative damage to cells and tissues, a process in which these organelles may play a prominent role, although alternative theories have also emerged. Furthermore, mitochondrial energy metabolism is also crucial for male reproductive function and mitochondria may therefore constitute a common link between aging and fertility loss. PMID:20021411

  14. The impact of an increase in the legal retirement age on the effective retirement age.

    Bernal, Noelia; Vermeulen, Frederic


    We analyze the impact of an increase in the legal retirement age on the effective retirement age in the Netherlands. We do this by means of a dynamic programming model for the retirement behavior of singles. The model is applied to new administrative data that contain very accurate and detailed information on individual incomes and occupational pension entitlements. Our model is able to capture the main patterns observed in the data. We observe that as individuals get older their labor supply...

  15. Epigenetics and aging

    Pal, Sangita; Tyler, Jessica K.


    Over the past decade, a growing number of studies have revealed that progressive changes to epigenetic information accompany aging in both dividing and nondividing cells. Functional studies in model organisms and humans indicate that epigenetic changes have a huge influence on the aging process. These epigenetic changes occur at various levels, including reduced bulk levels of the core histones, altered patterns of histone posttranslational modifications and DNA methylation, replacement of canonical histones with histone variants, and altered noncoding RNA expression, during both organismal aging and replicative senescence. The end result of epigenetic changes during aging is altered local accessibility to the genetic material, leading to aberrant gene expression, reactivation of transposable elements, and genomic instability. Strikingly, certain types of epigenetic information can function in a transgenerational manner to influence the life span of the offspring. Several important conclusions emerge from these studies: rather than being genetically predetermined, our life span is largely epigenetically determined; diet and other environmental influences can influence our life span by changing the epigenetic information; and inhibitors of epigenetic enzymes can influence life span of model organisms. These new findings provide better understanding of the mechanisms involved in aging. Given the reversible nature of epigenetic information, these studies highlight exciting avenues for therapeutic intervention in aging and age-associated diseases, including cancer. PMID:27482540

  16. Age Crises, Scalar Fields, and the Apocalypse

    Jackson, J. C.

    Recent observations suggest that Hubble's constant is large, to the extent that the oldest stars appear to have ages which are greater than the Hubble time, and that the Hubble expansion is slowing down, so that according to conventional cosmology the age of the Universe is less than the Hubble time. The concepts of weak and strong age crises (respectively t01/H0 and q0>0) are introduced. These observations are reconciled in models which are dynamically dominated by a homogeneous scalar field, corresponding to an ultra-light boson whose Compton wavelength is of the same order as the Hubble radius. Two such models are considered, an open one with vacuum energy comprising a conventional cosmological term and a scalar field component, and a flat one with a scalar component only, aimed respectively at weak and strong age crises. Both models suggest that anti-gravity plays a significant role in the evolution of the Universe.

  17. Skin aging: are adipocytes the next target?

    Kruglikov, Ilja L; Scherer, Philipp E


    Dermal white adipose tissue (dWAT) is increasingly appreciated as a special fat depot. The adipocytes in this depot exert a variety of unique effects on their surrounding cells and can undergo massive phenotypic changes. Significant modulation of dWAT content can be observed both in intrinsically and extrinsically aged skin. Specifically, skin that has been chronically photo-damaged displays a reduction of the dWAT volume, caused by the replacement of adipocytes by fibrotic structures. This is likely to be caused by the recently uncovered process described as "adipocyte-myofibroblast transition" (AMT). In addition, contributions of dermal adipocytes to the skin aging processes are also indirectly supported by spatial correlations between the prevalence of hypertrophic scarring and the appearance of signs of skin aging in different ethnic groups. These observations could elevate dermal adipocytes to prime targets in strategies aimed at counteracting skin aging. PMID:27434510

  18. Three ages of Venus

    Wood, Charles A.; Coombs, Cassandra R.


    A central question for any planet is the age of its surface. Based on comparative planetological arguments, Venus should be as young and active as the Earth (Wood and Francis). The detection of probable impact craters in the Venera radar images provides a tool for estimating the age of the surface of Venus. Assuming somewhat different crater production rates, Bazilevskiy et al. derived an age of 1 + or - 0.5 billion years, and Schaber et al. and Wood and Francis estimated an age of 200 to 400 million years. The known impact craters are not randomly distributed, however, thus some area must be older and others younger than this average age. Ages were derived for major geologic units on Venus using the Soviet catalog of impact craters (Bazilevskiy et al.), and the most accessible geologic unit map (Bazilevskiy). The crater counts are presented for (diameters greater than 20 km), areas, and crater densities for the 7 terrain units and coronae. The procedure for examining the distribution of craters is superior to the purely statistical approaches of Bazilevskiy et al. and Plaut and Arvidson because the bins are larger (average size 16 x 10(6) sq km) and geologically significant. Crater densities define three distinct groups: relatively heavily cratered (Lakshmi, mountain belts), moderately cratered (smooth and rolling plains, ridge belts, and tesserae), and essentially uncratered (coronae and domed uplands). Following Schaber et al., Grieve's terrestrial cratering rate of 5.4 + or - 2.7 craters greater than 20 km/10(9) yrs/10(6) sq km was used to calculate ages for the geologic units on Venus. To improve statistics, the data was aggregated into the three crater density groups, deriving the ages. For convenience, the three similar age groups are given informal time stratigraphic unit names, from youngest to oldest: Ulfrunian, Sednaian, Lakshmian.

  19. Forever young or ageing naturally?

    Van Hees, R.P.J.; Naldini, S.


    Age and ageing can be felt as negative occurrences. For monuments however, old age is traditionally considered to be a positive quality. Without a certain age the nomination of monument hardly applies. Ageing can be seen as the work of time, which has always been valued: ageing was sometimes even ar

  20. Growth hormone and aging

    Bartke, Andrzej; Brown-Borg, Holly; Kinney, Beth; Mattison, Julie; Wright, Chris; Hauck, Steven; Coschigano, Karen; Kopchick, John


    The potential usefulness of growth hormone (GH) as an anti-aging therapy is of considerable current interest. Secretion of GH normally declines during aging and administration of GH can reverse age-related changes in body composition. However, mutant dwarf mice with congenital GH deficiency and GH resistant GH-R-KO mice live much longer than their normal siblings, while a pathological elevation of GH levels reduces life expectancy in both mice and men. We propose that the actions of GH on gro...

  1. Vitamin D and Aging

    Gallagher, J. Christopher


    Aging affects the formation of 1,25-dihydroxyvitamin D (1,25[OH]2D; calcitriol), the active form of vitamin D. Production of 1,25(OH)2D is reduced by 50% as a result of an age-related decline in renal function, although serum 1,25(OH)2D levels are maintained in part by secondary hyperparathyroidism. Aging also causes a decrease in calcium absorption that precedes the decrease in 1,25(OH)2D by 10 to 15 years. Because 1,25(OH)2D is dependent on an adequate supply of the substrate vitamin D, the...

  2. Observation on the clinical therapeutic effect of compound glycyrrhizin tablets plus 2% Minoxidil for the treatment of alopecia areata in School -age Children%复方甘草酸苷联合2%米诺地尔液治疗学龄期儿童斑秃疗效观察

    岳振; 江从军


    Objective To examine the clinical efficacy and safety of compound Glycyrrhizin Tablets (CGT) plus 2%minoxidil for the treatment of alopecia areata in School -age Children.Methods 110 subjects were randomly allocated into 2 groups: 55 cases in treatment group which were treated by CGT plus 2%minoxidil;55 cases in control group which were treated only by 2% minoxidil.The outcome measures included effective rate and adverse events were observed in the 3rd month since the treatment.Results On the 3rd month of treatment, the total effective rate of treatment group was 90.91%and it was higher than the control group (70. 91%) .All these 2 groups had no obvious adverse events during the treatment .Conclusions CGT plus 2%minoxidil appears effective and safe for alopecia areata in School -age Children .%目的 探讨复方甘草酸苷联合2%米诺地尔液治疗学龄期儿童斑秃的临床疗效及安全性.方法 将110例患者随机等分为试验组和对照组,试验组口服复方甘草酸苷片,同时联合外用2%米诺地尔液;对照组外用2%米诺地尔液,用法用量同试验组,治疗3月后观察疗效. 结果 两组患者治疗3个月后,试验组的有效率及治愈率均显著高于对照组,且均未见明显不良反应. 结论 复方甘草酸苷联合2%米诺地尔液治疗学龄期儿童斑秃安全、有效,值得临床推广使用.

  3. Regeneration in the aging peripheral nervous system

    Painter, Michio Wendell


    In the peripheral nervous system (PNS), aging is associated with a number of disorders, including a decline in regenerative capacity after injury. Although this decline has been observed in both rodents and humans for decades, the cellular and molecular underpinnings of this defect have remained elusive. As such, the goal of this thesis was to elucidate, at least in part, how aging impinges on axonal regeneration.

  4. [Epidermal aging and anti-aging strategies].

    Wohlrab, J; Hilpert, K; Wolff, L


    Epithelial senescence is a complex process depending on intrinsic as well as extrinsic factors (e.g., UV or IR light, tobacco smoke) and must be seen in the context of the aging process especially of the corium and the subcutis. Morphological alterations become apparent in the form of epithelial atrophy, structural changes within the basal membrane, and a decrease in cell count of melanocytes and Langerhans cells. Signs of cellular senescence are reduced proliferation of keratinocytes, cumulation of dysplastic keratinocytes, various mutations (e.g., c-Fos/c-Jun, STAT3, FoxO1), as well as multiple lipid or amino acid metabolic aberrations (e.g., production of advanced glycation endproducts). This causes functional changes within the physical (lipid deficiency, water distribution dysfunction, lack of hygroscopic substances), chemical (pH conditions, oxygen radicals), and immunological barrier. Prophylactically, barrier-protective care products, antioxidant substances (e.g., vitamin C, B3, E, polyphenols, flavonoids), sunscreen products/measurements, and retinoids are used. For correcting alterations in aged epidermis, chemical peelings (fruit acids, β-hydroxy acid, trichloroacetic acid, phenolic compounds), non-ablative (IPL, PDL, Nd:YAG) as well as ablative (CO2, Erbium-YAG) light-assisted methods are used. PMID:26636143

  5. Analyzer of Spectra for Age Determination (ASAD) - Algorithm and Applications

    Asa'd, Randa


    Analyzer of Spectra for Age Determination (ASAD) is a new package that can easily predict the age and reddening of stellar clusters from their observed optical integrated spectra by comparing them to synthesis model spectra. The ages obtained with ASAD are consistent with ages obtained from previous cluster age methods requiring a more rigorous and time-consuming analysis. This package not only provides fast results, but also allows the user to comprehend the accuracy of these results by providing surface plots and spectral plots for all combinations of observations and models. ASAD is available for download on the Web and can be immediately used on both Mac and Windows.

  6. Paternal age and offspring congenital heart defects

    Su, Xiu Juan; Yuan, Wei; Huang, Guo Ying;


    Paternal age has been associated with offspring congenital heart defects (CHDs), which might be caused by increased mutations in the germ cell line because of cumulated cell replications. Empirical evidences, however, remain inconclusive. Furthermore, it is unknown whether all subtypes of CHDs are.......17-2.43). We observed similar results when subanalyses were restricted to children born to mothers of 27-30 years old. After taking into consideration of maternal age, our data suggested that advanced paternal age was associated with an increased prevalence of one subtype of offspring congenital heart defects...

  7. HEU age determination

    A technique has been developed to determine the Highly Enriched Uranium (HEU) Age which is defined as the time since the HEU was produced in an enrichment process. The HEU age is determined from the ratios of relevant uranium parents and their daughters viz 230Th/234U and 231Pa/235U. Uranium isotopes are quantitatively measured by their characteristic gammas and their daughters by alpha spectroscopy. In some of the samples where HEU is enriched more than 99%, the only mode of HEU age determination is by the measurement of 231Pa since there is negligible quantity of 230Th due to very low atom concentrations of 234U in the sample. In this paper we have presented data and methodology of finding the age of two HEU samples

  8. Global Health and Aging

    ... 9 12 16 18 20 22 25 4 Global Health and Aging Preface The world is facing ... stages of economic development and with varying resources. Global efforts are required to understand and find cures ...

  9. Sleep and Aging

    ... version of this page please turn Javascript on. Sleep and Aging About Sleep We all look forward to a good night's ... health and quality of life. Two Types of Sleep There are two types of sleep: non-rapid ...

  10. Sleep and Aging: Insomnia

    ... page please turn Javascript on. Sleep and Aging Insomnia Insomnia is the most common sleep complaint at ... at greater risk for falling. Health Issues and Insomnia Disorders that cause pain or discomfort during the ...

  11. Ageing of research reactors

    Historically, many of the research institutions were centred on a research reactor facility as main technological asset and major source of neutrons for research. Important achievements were made in time in these research institutions for development of nuclear materials technology and nuclear safety for nuclear energy. At present, ageing of nuclear research facilities among these research reactors and ageing of staff are considerable factors of reduction of competence in research centres. The safe way of mitigation of this trend deals with ageing management by so called, for power reactors, Plant Life Management and new investments in staff as investments in research, or in future resources of competence. A programmatic approach of ageing of research reactors in correlation with their actual and future utilisation, will be used as a basis for safety evaluation and future spending. (author)

  12. Forest Stand Age

    U.S. Geological Survey, Department of the Interior — Source data for forest stand age were obtained from the USDA Forest Inventory and Analysis (FIA) DataMart and were projected for future scenarios based on selected...

  13. Cellular Homeostasis and Aging.

    Hartl, F Ulrich


    Aging and longevity are controlled by a multiplicity of molecular and cellular signaling events that interface with environmental factors to maintain cellular homeostasis. Modulation of these pathways to extend life span, including insulin-like signaling and the response to dietary restriction, identified the cellular machineries and networks of protein homeostasis (proteostasis) and stress resistance pathways as critical players in the aging process. A decline of proteostasis capacity during aging leads to dysfunction of specific cell types and tissues, rendering the organism susceptible to a range of chronic diseases. This volume of the Annual Review of Biochemistry contains a set of two reviews addressing our current understanding of the molecular mechanisms underlying aging in model organisms and humans. PMID:27050288

  14. Stress, Inflammation and Aging

    Lavretsky, Helen; Newhouse, Paul A.


    This editorial provides a summary of the state of research on stress-related changes associated with aging and discuss how factors such as inflammation and sex steroid alterations may interact with psychosocial stress to affect the risk for mood and cognitive disturbance in older individuals. The authors provide an integrated summary of four studies reported in this issue of the journal and views on future direction in stress and aging research and interventions targeting resilience to stress.

  15. Evolution and Ageing

    de Oliveira, S. Moss; Alves, Domingos; Martins, J. S. Sa


    The idea of this review is to connect the different models of evolution to those of biological ageing through Darwin's theory. We start with the Eigen model of quasispecies for microevolution, then introduce the Bak-Sneppen model for macroevolution and, finally, present the Penna model for biological ageing and some of its most important results. We also explore the concept of coevolution using this model.


    Francisco M. Lagos; Juan Antonio Lacomba


    We analyze the relationship between wage distribution, degree of redistribution of the Social Security and effective retirement age. We develop a two-staged political economy model. In the first stage government chooses the redistribution level of the Social Security Program, according to three different criteria. In second stage the retirement age is elected through a majority voting process by agents with different wages, knowing exactly the redistribution level and voting accordingly. We a...

  17. Modulating aging and longevity

    Rattan, Suresh

    Provides information and an evaluation of a variety of approaches tried for modulating aging and longevity, including dietary supplementation with antioxidants, vitamins and hormones, genetic engineering, life-style alterations, and hormesis through mild stress. After decades of systematic...... mild stress. The goal of research on ageing is not to increase human longevity regardless of the consequences, but to increase active longevity free from disability and functional dependence...

  18. Aging and sexuality.

    Holzapfel, S.


    Recent research suggesting that a high proportion of men and women remain sexually active well into later life refutes the prevailing myth that aging and sexual dysfunction are inexorably linked. Age-related physiological changes do not render a meaningful sexual relationship impossible or even necessarily difficult. In men, greater physical stimulation is required to attain and maintain erections, and orgasms are less intense. In women, menopause terminates fertility and produces changes ste...

  19. Age Discrimination in Italy

    Olga Rymkevitch; Claudia Villosio


    The Framework Directive on Equal Treatment in Employment and Occupation (2000/78/EC) included age as one of its prohibited grounds of discrimination. Member States were required to transpose this Directive by December 2003. In Italy age discrimination was explicitly regulated by means of Legislative Decree no. 216, 9 July 2003. The Decree introduced the new specific prohibition of discrimination, defining its application, exceptions and remedies. The purpose of this paper is to explore, in a ...

  20. Classifier in Age classification

    B. Santhi; R.Seethalakshmi


    Face is the important feature of the human beings. We can derive various properties of a human by analyzing the face. The objective of the study is to design a classifier for age using facial images. Age classification is essential in many applications like crime detection, employment and face detection. The proposed algorithm contains four phases: preprocessing, feature extraction, feature selection and classification. The classification employs two class labels namely child and Old. This st...

  1. Exercise, Inflammation and Aging

    Jeffrey A Woods; Wilund, Kenneth R.; Martin, Stephen A.; Kistler, Brandon M.


    Aging results in chronic low grade inflammation that is associated with increased risk for disease, poor physical functioning and mortality. Strategies that reduce age-related inflammation may improve the quality of life in older adults. Regular exercise is recommended for older people for a variety of reasons including increasing muscle mass and reducing risk for chronic diseases of the heart and metabolic systems. Only recently has exercise been examined in the context of inflammation. This...

  2. Aging aspects of DEB getters

    Dinh, L.N., E-mail: [Lawrence Livermore National Laboratory, Livermore, CA (United States); Cairns, G.A. [AWE plc, Aldermaston, Reading (United Kingdom); Krueger, R.; Mayer, B.P.; Maxwell, R.S. [Lawrence Livermore National Laboratory, Livermore, CA (United States)


    The changes in uptake capacity of 1,4-bis(phenylethynyl)benzene (DEB) blended with carbon-supported Pd (DEB-Pd/C) in the form of pellets as a function of temperature and time were investigated. Experimental results revealed a segregation and crystallization of DEB molecules toward the geometrical surfaces of the getter pellets, but very little or no diffusion-aggregation of Pd nano-catalysts even after long term storage at 75 °C in nitrogen. Despite the observation of surface segregation and crystallization of DEB molecules with increasing temperature and time, statistically there was no reduction in uptake capacity for the getter pellets stored at higher temperature. However, significant reversible reductions in uptake capacity was found among getter pellets exposed to air for extended time. The possible causes for these observations and their respective roles in the aging of getters are discussed.

  3. Clinical observation of the age-related cataract PCC combined with IOL implantation%老年性白内障超声乳化吸后囊环形撕开联合人工晶状体植入术临床观察

    林涛; 张军


    Objective To observe the age-related cataract PCC combined with IOL implantation. Methods All patients from our hospital aged from 52-90 years old ,who have no hypertension , diabetic mellitus, hyeropia , and lens subluxation ,no glaucoma, male 32 ,female 28. they undergo pcc or no pcc and who have both eyes cataract. observe at least one year. Result VA 100. 1 ~ 0.3 ,360. 3 ~ 0. 6 , 140. 6. no retinal detachment ,2% CME , there is no difference between two groups. Conclusion It is a safe method when combining PCC and IOL implantation , and it is effective to prevent PCO.%目的 观察老年性白内障超声乳化吸除后囊环形撕开联合人工晶状体植入术的临床疗效.方法 选取2010年1月至2010年4月在我院门诊和病房行老年性白内障超声乳化手术的患者30例(60只眼),均为双眼白内障患者,除外高血压、糖尿病、高度近视、晶状体脱位以及半脱位,青光眼以及囊膜剥脱的患者.年龄在52~90岁,男32例,女28例.患者一眼行后囊撕开、另一眼行不撕开手术,植入同种人工晶状体.手术后随访1年.结果 术后矫正视力0.1~0.3者10只眼,0.3~0.6者36只眼,0.6以上者14只眼,无视网膜脱离发生,黄斑囊样水肿患者为3.3%.两组无明显差异.所有术眼无人工晶状体脱位,轻度偏位的发生率为6%.结论 老年性白内障超声乳化手术后囊环形撕开联合人工晶状体植入,是一种安全有效的手术技术,可以有效防止后囊浑浊,远期手术并发症少,黄斑囊样水肿和视网膜脱离的发病率与常规白内障超声乳化手术无统计学差异.

  4. Observation on curative effect of preschool-aged children with cerebral palsy by occupational therapy in groups%采用小组形式开展作业疗法治疗学龄前脑瘫儿童的疗效观察

    谭玮玮; 陈国治; 张明武; 罗寀宾; 谭海萍; 蒋锦生


    目的:观察以小组形式开展作业疗法治疗学龄前脑瘫儿童的临床效果。方法20例痉挛型双瘫的脑瘫患儿按随机数字表法分为对照组( n=10)和观察组( n=10)。对照组的作业治疗采用一对一的训练方法,观察组采用2名脑瘫儿童为一小组形式开展作业治疗,1次/d,30 min/次,每周5 d,治疗3个月。结果两组治疗后,精细运动功能及日常生活活动能力显著提高(P<0.01),观察组与对照组效果差异无统计学意义( P>0.05)。结论以小组形式与传统一对一形式开展作业治疗均能明显提高脑瘫患儿的精细运动功能及日常生活活动能力,治疗效果差异无统计学意义。%Objective To investigate the clinical effect of treating preschool-aged children with cerebral pal-sy by occupational therapy in groups.Methods Twenty children with spastic diplegia were randomly divided into control group(n=10) and observation group(n=10).Occupational therapy of the control group was conducted in a one-to-one training way while the observation group was conducted in groups of 2 children once a day, each time last-ing for 30 minutes, 5 days each week for 3 months.Results After the therapy, the Fine Motor Function( FMF) and Activities of Daily Living(ADL) in both groups significantly improved(P0.05).Conclusion Both occupational therapy in the ways of groups and traditional one-to-one can substantially improve the FMF and ADL of children with cerebral palsy, and there is no significant difference in the treatment effect.

  5. Age differences in mental health literacy

    Christensen Helen


    Full Text Available Abstract Background The community's knowledge and beliefs about mental health problems, their risk factors, treatments and sources of help may vary as a function of age. Methods Data were taken from an epidemiological survey conducted during 2003–2004 with a national clustered sample of Australian adults aged 18 years and over. Following the presentation of a vignette describing depression (n = 1001 or schizophrenia (n = 997, respondents were asked a series of questions relating to their knowledge and recognition of the disorder, beliefs about the helpfulness of treating professionals and medical, psychological and lifestyle treatments, and likely causes. Results Participant age was coded into five categories and cross-tabulated with mental health literacy variables. Comparisons between age groups revealed that although older adults (70+ years were poorer than younger age groups at correctly recognising depression and schizophrenia, young adults (18–24 years were more likely to misidentify schizophrenia as depression. Differences were also observed between younger and older age groups in terms of beliefs about the helpfulness of certain treating professionals and medical and lifestyle treatments for depression and schizophrenia, and older respondents were more likely to believe that schizophrenia could be caused by character weakness. Conclusion Differences in mental health literacy across the adult lifespan suggest that more specific, age appropriate messages about mental health are required for younger and older age groups. The tendency for young adults to 'over-identify' depression signals the need for awareness campaigns to focus on differentiation between mental disorders.

  6. Olfactory phenotypic expression unveils human aging

    Mazzatenta, Andrea; Cellerino, Alessandro; Origlia, Nicola; Barloscio, Davide; Sartucci, Ferdinando; Giulio, Camillo Di; Domenici, Luciano


    The mechanism of the natural aging of olfaction and its declinein the absence of any overt disease conditions remains unclear. Here, we investigated this mechanism through measurement of one of the parameters of olfactory function, the absolute threshold, in a healthy population from childhood to old age. The absolute olfactory threshold data were collected from an Italian observational study with 622 participants aged 5-105 years. A subjective testing procedure of constant stimuli was used, which was also compared to the ‘staircase’ method, with the calculation of the reliability. The n-butanol stimulus was used as an ascending series of nine molar concentrations that were monitored using an electronic nose. The data were analyzed using nonparametric statistics because of the multimodal distribution. We show that the age-related variations in the absolute olfactory threshold are not continuous; instead, there are multiple olfactory phenotypes. Three distinct age-related phenotypes were defined, termed as ‘juvenile’, ‘mature’ and ‘elder’. The frequency of these three phenotypes depends on age. Our data suggest that the sense of smell does not decrease linearly with aging. Our findings provide the basis for further understanding of olfactory loss as an anticipatory sign of aging and neurodegenerative processes. PMID:27027240

  7. Age-specific breeding in Emperor Geese

    Schmutz, J.A.


    I studied the frequency with which Emperor Geese (Chen canagica) of known age were observed breeding on the Yukon-Kuskokwim Delta, Alaska. No one- or two-year old geese were observed on nests. Three-year old geese bred at a lower rate than four-year old geese. These data suggest that patterns of age-specific breeding in Emperor Geese are similar to other sympatrically nesting, large bodied geese [Greater White-fronted Geese (Anser albifrons)] but delayed relative to smaller bodied geese [Cackling Canada Geese (Branta canadensis minima) and Pacific Black Brant (B. bernicla nigricans)].

  8. The Gestational Age Pattern of Human Mortality

    Schöley, Jonas

    I present a lifetable by gestational age from week 23 until week 100 after the last menstrual period of the mother. The lifetable shows the pre-natal, peri-natal and post-natal mortality levels for US fetus/infants conceived in the year 2009. The observed age pattern of the force of mortality is ...... mortality are correct. Additionally, I conclude that the phenomenon of "ontogenesis" -- the decreasing force of mortality from birth until onset of maturity observed in many species -- is, for modern humans, explained by adaptation and mortality selection alone....

  9. Brain atrophy during aging

    Age-related brain atrophy was investigated in thousands of persons with no neurologic disturbances using X-CT and NMR-CT. Brain atrophy was minimal in 34-35 years old in both sexes, increased exponentially to the increasing age after 34-35 years, and probably resulted in dementia, such as vascular or multi-infarct dementia. Brain atrophy was significantly greater in men than in women at all ages. Brain volumes were maximal in 34-35 years old in both sexes with minimal individual differences which increased proportionally to the increasing age. Remarkable individual differences in the extent of brain atrophy (20 - 30 %) existed among aged subjects. Progression of brain atrophy was closely related to loss of mental activities independently of their ages. Our longitudinal study has revealed that the most important factors promoting brain atrophy during aging was the decrease in the cerebral blood flow. We have classified brain atrophy into sulcal and cisternal enlargement type (type I), ventricular enlargement type (type II) and mixed type (type III) according to the clinical study using NMR-CT. Brain atrophy of type I progresses significantly in almost all of the geriatric disorders. This type of brain atrophy progresses significantly in heavy smokers and drinkers. Therefore this type of brain atrophy might be caused by the decline in the blood flow in anterior and middle cerebral arteries. Brain atrophy of type II was caused by the disturbance of cerebrospinal fluid circulation after cerebral bleeding and subarachnoid bleeding. Brain atrophy of type III was seen in vascular dementia or multi-infarct dementia which was caused by loss of brain matter after multiple infarction, and was seen also in dementia of Alzheimer type in which degeneration of nerve cells results in brain atrophy. NMR-CT can easily detect small infarction (lacunae) and edematous lesions resulting from ischemia and hypertensive encephalopathy. (J.P.N.)

  10. Cognitive aging in zebrafish.

    Lili Yu

    Full Text Available BACKGROUND: Age-related impairments in cognitive functions represent a growing clinical and social issue. Genetic and behavioral characterization of animal models can provide critical information on the intrinsic and environmental factors that determine the deterioration or preservation of cognitive abilities throughout life. METHODOLOGY/PRINCIPAL FINDINGS: Behavior of wild-type, mutant and gamma-irradiated zebrafish (Danio rerio was documented using image-analysis technique. Conditioned responses to spatial, visual and temporal cues were investigated in young, middle-aged and old animals. The results demonstrate that zebrafish aging is associated with changes in cognitive responses to emotionally positive and negative experiences, reduced generalization of adaptive associations, increased stereotypic and reduced exploratory behavior and altered temporal entrainment. Genetic upregulation of cholinergic transmission attenuates cognitive decline in middle-aged achesb55/+ mutants, compared to wild-type siblings. In contrast, the genotoxic stress of gamma-irradiation accelerates the onset of cognitive impairment in young zebrafish. CONCLUSIONS/SIGNIFICANCE: These findings would allow the use of powerful molecular biological resources accumulated in the zebrafish field to address the mechanisms of cognitive senescence, and promote the search for therapeutic strategies which may attenuate age-related cognitive decline.

  11. [Strategies for successful ageing].

    Orozco Ríos, Adriana Martha; López Velarde Peña, Tatiana; Martínez Gallardo Prieto, Lorenza


    There has been an increase in the interest of anti-ageing medicine in the last few years, with a growth in the industry of products that promise to prolong life and restore all the suffering or "defects" produced by age. The understanding of ageing has changed over the years, giving rise to the possibility of intervening in different metabolic and cellular pathways, and thus, delaying the appearance of the degenerative chronic diseases that appear with age, and that are finally the causing factors of the vulnerability that leads to our death. It is hoped that we can help the clinician to orientate their patients, who, due to the overwhelming amount of information they receive by the Internet, arrive at the clinic full of questions, waiting to receive absolute answer from their physician in order to increase their longevity and quality of life. This article presents an analysis of the physical activity, diets, supplements and drugs that are being investigated as anti-ageing measures and of the many clinical studies that have produced encouraging, measurable and reproducible results. PMID:26656211

  12. Aging and dark adaptation.

    Jackson, G R; Owsley, C; McGwin, G


    Older adults have serious difficulty seeing under low illumination and at night, even in the absence of ocular disease. Optical changes in the aged eye, such as pupillary miosis and increased lens density, cannot account for the severity of this problem, and little is known about its neural basis. Dark adaptation functions were measured on 94 adults ranging in age from the 20s to the 80s to assess the rate of rod-mediated sensitivity recovery after exposure to a 98% bleach. Fundus photography and a grading scale were used to characterize macular health in subjects over age 49 in order to control for macular disease. Thresholds for each subject were corrected for lens density based on individual estimates, and pupil diameter was controlled. Results indicated that during human aging there is a dramatic slowing in rod-mediated dark adaptation that can be attributed to delayed rhodopsin regeneration. During the second component of the rod-mediated phase of dark adaptation, the rate of sensitivity recovery decreased 0.02 log unit/min per decade, and the time constant of rhodopsin regeneration increased 8.4 s/decade. The amount of time to reach within 0.3 log units of baseline scotopic sensitivity increased 2.76 min/decade. These aging-related changes in rod-mediated dark adaptation may contribute to night vision problems commonly experienced by the elderly. PMID:10748929

  13. Stress, Aging and Thirst

    Greenleaf, John E.


    After growth during adolesence, total body water decreases progressively with aging from 65% of body weight to about 53% of body weight in the 70th decade; a majority of the loss occurs from the extracellular volume, from 42% to about 25%, respectively. Cellular volume also reaches equilibrium in the 70th decade at about 25% of body weight. Various stresses such as exercise, heat and attitude exposure, ad prior dehydration attenuate voluntary fluid intake (involuntary dehydration). Voluntary fluid intake appears to decrease with aging (involuntary dehydration in this sense aging can be considered as a stress. Kidney function and muscle mass (80% water) decrease somewhat with aging, and voluntary fluid intake (thirst) is also attenuated. Thirst is stimulated by increasing osmolality (hypernatremia) of the extracellular fluid and by decreased extracellular volume (mainly plasma volume) which act to increase intracellular fluid volume osmolality to activiate drinking. The latter decreases fluid compartment osmolality which ' It terminates drinking. However, this drinking mechanism seems to be attenuated with aging such that increasing plasma osmolality no longer stimulates fluid intake appropriately. Hypernatremia in the elderly has been associated all too frequently with greater incidence of bacterial infection and increased mortality. Involuntary dehydration can be overcome in young men by acclimation to an intermittent exercise-in-heat training program. Perhaps exercise training in the elderly would also increase voluntary fluid intake and increase muscle mass to enhance retention of water.

  14. The relationship between dental age, bone age and chronological age in underweight children

    Vinod Kumar; Karthik Venkataraghavan; Ramesh Krishnan; Kavitha Patil; Karishma Munoli; Sandhya Karthik


    Background and Objective: The knowledge of bone age and dental age is of great importance for pediatrician and pediatric dentist. It is essential for a pediatric dentist to formulate treatment plan and it is a source of complementary information for pediatrician. There are few studies, which showed the relationship between dental age, bone age and chronological age in underweight children. Therefore, objective of this study was to determine and compare dental age, bone age and chronological a...

  15. Signatures of aging

    Cornwall, J.; Dyson, F.; Garwin, R.; Hammer, D.; Happer, W.; Lewis, N.; Schwitters, R.; Sullivan, J.; Williams, E.


    The Department of Energy and its three weapons laboratories (LANL, LLNL, and SNL) have developed a Stockpile Stewardship and Management Program (SSMP) in response to their designated mission of maintaining an effective, i.e. reliable and safe, nuclear deterrent without underground nuclear tests (UGTs). The need to ensure the effectiveness of an aging stockpile presents new challenges of major importance. In this study we review what is known about the aging of critical constituents, particularly the high explosives, polymers, and metals in the enduring stockpile. We discuss data that are required to provide a fuller understanding of aging, and how to obtain that data as a basis for anticipating and addressing potential stockpile problems. Our particular concern is problems that may arise in the short term, i.e. within the next 5 to 10 years, and their implied requirements for preventive maintenance and remanufacture.

  16. Cancer and aging

    Pedersen, Jacob K; Engholm, Gerda; Skytthe, Axel;


    Epidemiological cancer data shed light on key questions within basic science, clinical medicine and public health. For decades, Denmark has had linkable health registers that contain individual level data on the entire population with virtually complete follow-up. This has enabled high quality...... studies of cancer epidemiology and minimized the challenges often faced in many countries, such as uncertain identification of the study base, age misreporting, and low validity of the cancer diagnoses. However, methodological challenges still remain to be addressed, especially in cancer epidemiology...... studies among the elderly and the oldest-old. For example, a characteristic pattern for many cancer types is that the incidence increases up to a maximum at about ages 75-90 years and is then followed by a decline or a leveling off at the oldest ages. It has been suggested that the oldest individuals may...

  17. Ageing Management Program Database

    The aspects of plant ageing management (AM) gained increasing attention over the last ten years. Numerous technical studies have been performed to study the impact of ageing mechanisms on the safe and reliable operation of nuclear power plants. National research activities have been initiated or are in progress to provide the technical basis for decision making processes. The long-term operation of nuclear power plants is influenced by economic considerations, the socio-economic environment including public acceptance, developments in research and the regulatory framework, the availability of technical infrastructure to maintain and service the systems, structures and components as well as qualified personnel. Besides national activities there are a number of international activities in particular under the umbrella of the IAEA, the OECD and the EU. The paper discusses the process, procedure and database developed for Slovenian Nuclear Safety Administration (SNSA) surveillance of ageing process of Nuclear power Plant Krsko.(author)

  18. Glucose and Aging

    Ely, John T. A.


    When a human's enzymes attach glucose to proteins they do so at specific sites on a specific molecule for a specific purpose that also can include ascorbic acid (AA) at a high level such as 1 gram per hour during exposure. In an AA synthesizing animal the manifold increase of AA produced in response to illness is automatic. In contrast, the human non-enzymatic process adds glucose haphazardly to any number of sites along available peptide chains. As Cerami clarified decades ago, extensive crosslinking of proteins contributes to loss of elasticity in aging tissues. Ascorbic acid reduces the random non-enyzmatic glycation of proteins. Moreover, AA is a cofactor for hydroxylase enzymes that are necessary for the production and replacement of collagen and other structural proteins. We will discuss the relevance of ``aging is scurvy'' to the biochemistry of human aging.

  19. Redox theory of aging

    Dean P. Jones


    Full Text Available Metazoan genomes encode exposure memory systems to enhance survival and reproductive potential by providing mechanisms for an individual to adjust during lifespan to environmental resources and challenges. These systems are inherently redox networks, arising during evolution of complex systems with O2 as a major determinant of bioenergetics, metabolic and structural organization, defense, and reproduction. The network structure decreases flexibility from conception onward due to differentiation and cumulative responses to environment (exposome. The redox theory of aging is that aging is a decline in plasticity of genome–exposome interaction that occurs as a consequence of execution of differentiation and exposure memory systems. This includes compromised mitochondrial and bioenergetic flexibility, impaired food utilization and metabolic homeostasis, decreased barrier and defense capabilities and loss of reproductive fidelity and fecundity. This theory accounts for hallmarks of aging, including failure to maintain oxidative or xenobiotic defenses, mitochondrial integrity, proteostasis, barrier structures, DNA repair, telomeres, immune function, metabolic regulation and regenerative capacity.

  20. Age and Value Orientations

    Asya Kh. Kukubayeva


    Full Text Available The present article deals with value orientations and their role in men’s lives, particularly, in young people’s lives. This notion was introduced by the American theoretical sociologist T. Parsons, one of the creators of modern theoretical sociology. The scientist made an attempt to construct the structural and analytical theory of social action, combining personal interests (needs and aims and situation, it takes place in. The issue of value orientations remains acute for psychology. Herein we have considered several most important works, relating to the considered issue. Age aspects of young people’s value orientations are of peculiar interest to us. When analyzing this phenomenon, one should take into consideration the psychological formations, inhere for a certain age. In fact every age has its unique structure, which may change when passing from one development stage to another. Basing on this fact, we’ve considered the values, depending on the age features of the youth, relying upon the works of the scientists, working with different categories of the youth, such as: teenagers, students, children of different nationalities. It is not surprising that most scientists have come to the conclusion that the chief role in value orientation belongs to a family, originates in relations with parents and teachers. The positive reinforcement to the future develops throughout life in accordance with a lifestyle of a family, society and political situation in a state.Life orientations as a type of value orientations show different types of young people’s preferences. Value structure of its consciousness has its own specific character, depending on the age peculiarities. The dynamics of the transition from one age to another is accompanied with the reappraisal of values, eventually, influencing the life strategy of the future generation

  1. Nutrition and Ageing.

    Minuti, Andrea; Patrone, Vania; Giuberti, Gianluca; Spigno, Giorgia; Pietri, Amedeo; Battilani, Paola; Ajmone Marsan, Paolo


    The world elderly population is rapidly increasing. This demographic change represents a new challenge for the society and demands for a multisectorial intervention to promote a long, healthy, and active life span. Between the factors that contribute in fostering a long healthy life, the nutritional regime plays a central role and is recognized as a major factor in the onset of chronic diseases. A better understanding of the interaction between nutrition and ageing is essential to unravel the mechanisms responsible for these positive/negative effects and to identify diet components promoting the quality of life in the old age and to contribute to the prevention of late-life disabilities. At Università Cattolica del Sacro Cuore, the research activity in food science is focusing on four main objectives: food quality, food safety, functional foods and diet balancing. These objectives are the target of multidisciplinary ongoing and future research activities for a better understanding of the link between diet and ageing. Briefly, the different activities are addressed to the study of the following subjects: the most relevant factors affecting food choices and habits of old aged persons; the effects of long term low dose supplementation of conjugated linoleic acid in mouse; the use of low glycemic index and high resistant starch foods to prevent diabetes and obesity; the adjuvant effect of food bacteria for vaccination; the role of food ingredients in disease; the immunosuppression effect of mycotoxins, and its relevance in ageing people; the production of sustainable and natural antioxidant ingredients to encourage a healthy diet. Our research projects emphasize an holistic and integrated approach that, by bringing together complementary research groups, can combine the collective expertise and thus provide a comprehensive assessment of the role of nutrition in healthy ageing people. PMID:26630518

  2. Genome instability and aging.

    Vijg, Jan; Suh, Yousin


    Genome instability has long been implicated as the main causal factor in aging. Somatic cells are continuously exposed to various sources of DNA damage, from reactive oxygen species to UV radiation to environmental mutagens. To cope with the tens of thousands of chemical lesions introduced into the genome of a typical cell each day, a complex network of genome maintenance systems acts to remove damage and restore the correct base pair sequence. Occasionally, however, repair is erroneous, and such errors, as well as the occasional failure to correctly replicate the genome during cell division, are the basis for mutations and epimutations. There is now ample evidence that mutations accumulate in various organs and tissues of higher animals, including humans, mice, and flies. What is not known, however, is whether the frequency of these random changes is sufficient to cause the phenotypic effects generally associated with aging. The exception is cancer, an age-related disease caused by the accumulation of mutations and epimutations. Here, we first review current concepts regarding the relationship between DNA damage, repair, and mutation, as well as the data regarding genome alterations as a function of age. We then describe a model for how randomly induced DNA sequence and epigenomic variants in the somatic genomes of animals can result in functional decline and disease in old age. Finally, we discuss the genetics of genome instability in relation to longevity to address the importance of alterations in the somatic genome as a causal factor in aging and to underscore the opportunities provided by genetic approaches to develop interventions that attenuate genome instability, reduce disease risk, and increase life span. PMID:23398157

  3. Religion and aging.

    Margaret Hall, C


    Life history data and cultural values are used to suggest ways in which personal and social beliefs influence the quality of experiences of aging. Central questions are the extent to which an individual can select beliefs that lead to a longer, more meaningful life and the special influence that religion may have in enhancing aging. Responsiveness to needs of the elderly is a necessary component of enlightened planning for the future. Secularization and industrialization have diminished roles and expectations for the elderly. Religion may be an effective means to identify these concerns and improve the quality of life of older people. PMID:24307195

  4. Aging changes in the face

    ... this page: // Aging changes in the face To use the sharing ... Changes in face with age References Brodie SE. Aging and disorders of the eye. In: Fillit HM, ...

  5. IGBT accelerated aging data set.

    National Aeronautics and Space Administration — Preliminary data from thermal overstress accelerated aging using the aging and characterization system. The data set contains aging data from 6 devices, one device...

  6. Sleep, ageing and night work

    M.L.N. Pires


    Full Text Available Studies have shown that the frequency or worsening of sleep disorders tends to increase with age and that the ability to perform circadian adjustments tends to decrease in individuals who work the night shift. This condition can cause consequences such as excessive sleepiness, which are often a factor in accidents that occur at work. The present study investigated the effects of age on the daytime and nighttime sleep patterns using polysomnography (PSG of long-haul bus drivers working fixed night or day shifts. A total of 124 drivers, free of sleep disorders and grouped according to age (<45 years, N = 85, and ≥45 years, N = 39 and PSG timing (daytime (D PSG, N = 60; nighttime (N PSG, N = 64 participated in the study. We observed a significant effect of bedtime (D vs N and found that the length of daytime sleep was shorter [D: <45 years (336.10 ± 73.75 min vs N: <45 years (398 ± 78.79 min and D: ≥45 years (346.57 ± 43.17 min vs N: ≥45 years (386.44 ± 52.92 min; P ≤ 0.05]. Daytime sleep was less efficient compared to nighttime sleep [D: <45 years (78.86 ± 13.30% vs N: <45 years (86.45 ± 9.77% and D: ≥45 years (79.89 ± 9.45% and N: ≥45 years (83.13 ± 9.13%; P ≤ 0.05]. An effect of age was observed for rapid eye movement sleep [D: <45 years (18.05 ± 6.12% vs D: ≥45 years (15.48 ± 7.11% and N: <45 years (23.88 ± 6.75% vs N: ≥45 years (20.77 ± 5.64%; P ≤ 0.05], which was greater in younger drivers. These findings are inconsistent with the notion that older night workers are more adversely affected than younger night workers by the challenge of attempting to rest during the day.

  7. Taurine increases hippocampal neurogenesis in aging mice

    Elias Gebara


    Full Text Available Aging is associated with increased inflammation and reduced hippocampal neurogenesis, which may in turn contribute to cognitive impairment. Taurine is a free amino acid found in numerous diets, with anti-inflammatory properties. Although abundant in the young brain, the decrease in taurine concentration with age may underlie reduced neurogenesis. Here, we assessed the effect of taurine on hippocampal neurogenesis in middle-aged mice. We found that taurine increased cell proliferation in the dentate gyrus through the activation of quiescent stem cells, resulting in increased number of stem cells and intermediate neural progenitors. Taurine had a direct effect on stem/progenitor cells proliferation, as observed in vitro, and also reduced activated microglia. Furthermore, taurine increased the survival of newborn neurons, resulting in a net increase in adult neurogenesis. Together, these results show that taurine increases several steps of adult neurogenesis and support a beneficial role of taurine on hippocampal neurogenesis in the context of brain aging.

  8. Aging of Organic Nanowires

    Balzer, Frank; Schiek, Manuela; Osadnik, Andreas;


    attribute, making them especially interesting for light generation in OLEDs and for light-harvesting devices such as solar cells. Functionalization of the molecules allows the customization of optical and electrical properties. However, aging of the wires might lead to a considerable decrease in device...

  9. Bronze Age Acrobats

    Iversen, Rune


    immaterial, ritual and cosmological exchange that characterized the second and early firstmillennium BC.Beliefs and ritual practices went hand in hand with the adoption of a series of elite items and an aristocratic lifestyle, thereby creating a unique and fascinating European Bronze Age....

  10. Time perception and age.

    Ferreira, Vanessa Fernanda Moreira; Paiva, Gabriel Pina; Prando, Natália; Graça, Carla Renata; Kouyoumdjian, João Aris


    Our internal clock system is predominantly dopaminergic, but memory is predominantly cholinergic. Here, we examined the common sensibility encapsulated in the statement: "time goes faster as we get older". Objective To measure a 2 min time interval, counted mentally in subjects of different age groups. Method 233 healthy subjects (129 women) were divided into three age groups: G1, 15-29 years; G2, 30-49 years; and G3, 50-89 years. Subjects were asked to close their eyes and mentally count the passing of 120 s. Results The elapsed times were: G1, mean = 114.9 ± 35 s; G2, mean = 96.0 ± 34.3 s; G3, mean = 86.6 ± 34.9 s. The ANOVA-Bonferroni multiple comparison test showed that G3 and G1 results were significantly different (P < 0.001). Conclusion Mental calculations of 120 s were shortened by an average of 24.6% (28.3 s) in individuals over age 50 years compared to individuals under age 30 years. PMID:27097002

  11. Curcumin and aging

    Curcumin has been used commonly as a spice, food additive, and an herbal medicine worldwide. Known as a bioactive polyphenolic, curcumin has a broad range of beneficial properties to human health. Recently, active research on curcumin with respect to aging and related traits in model organisms has d...

  12. Estrogens and aging skin

    Thornton, M. Julie


    Estrogen deficiency following menopause results in atrophic skin changes and acceleration of skin aging. Estrogens significantly modulate skin physiology, targeting keratinocytes, fibroblasts, melanocytes, hair follicles and sebaceous glands, and improve angiogenesis, wound healing and immune responses. Estrogen insufficiency decreases defense against oxidative stress; skin becomes thinner with less collagen, decreased elasticity, increased wrinkling, increased dryness and reduced vascularity...

  13. Ageing and safety

    Ageing is a continuous process which cannot be reversed but which can be controlled by replacing components. However, the replacement of some components may be impossible or uneconomical; therefore, monitoring and in-service inspections must be increased. The combination of replacement of components and increased monitoring should make possible the total control of ageing. In this connection, it can be said that it is necessary to produce components and systems which are appropriate to the useful life of the facility, otherwise safety will be affected; that the materials used should be carefully selected so as to reduce activation problems; that in any new design, the need for components, systems and programmes for decontamination of the facility must be taken into account; that in order to control ageing, the increase in the level of monitoring and the replacement of components should be planned as a function of time; and that maintaining a constant level of design monitoring and increasing the rate of component replacement alone does not constitute control of ageing. It is not possible to replace all the components and those which cannot be replaced (reactor vessel, steam generators, pressurizer, heat exchangers, etc.) would present a high risk of failure if the monitoring of them were not stepped up so as to allow timely corrective action to be taken. (author)

  14. Taste perception with age

    Mojet, J.


    Keywords: age, thresholds, supra-threshold intensities, pleasantness, optimally preferred concentration, olfactory deprivation,signal-to-noise ratio

    This thesis


    Mishchykha, Larysa


    The article focuses on the problem of a personality’s creative longevity. It is concluded that creative activity in the period of late ontogenesis should facilitate improvement of (a personality’s) life quality in the final period and, consequently, should become one of the significant factors of productive old age.

  16. CETA and the Aging.

    Schram, Sanford F.; Osten, David F.


    To assess the impact of the 1973 Comprehensive Employment and Training Act (CETA) on older worker's problems, article examines CETA's history, options, and authority. Finds major systemic factors that encourage local prime sponsors to understate aging populations' needs. Concludes there is a need for substantial CETA changes to effectively serve…

  17. Psychological Aspects of Aging.

    Mooney, Craig M.


    Psychological aspects of aging, based on gerontological hypotheses and research, are presented under three headings: intellectual abilities; emotional capacities; and motor capabilities. Consequences are discussed. Well-being throughout life depends on fulfillment of fundamental human needs; existential needs for nourishment, stimulation, rest,…

  18. A Bittersweet Age


    They are the first generation bom under the one-child policy that came into eifect about 30 years ago. Today this post-80s generation are mostly aged between 20-28 and lead independent lives. Their unique family environment is a far cry from that of their parents’ generation, and has helped shape a personality of

  19. Helping You Age Well

    ... Need and When / A Note on Complementary Medicines / Nutrition and the Aging Eye / In The Genes? Searching for Methuselah Winter 2007 Issue: Volume 2 Number 1 Page 9 MedlinePlus | Subscribe | Magazine Information | Contact Us | Viewers & Players Friends of the ...

  20. Chromium and aging

    Aging is associated with increased blood glucose, insulin, blood lipids, and fat mass, and decreased lean body mass leading to increased incidences of diabetes and cardiovascular diseases. Improved chromium nutrition is associated with improvements in all of these variables. Insulin sensitivity de...

  1. Protein oxidation and ageing

    Linton, S; Davies, Michael Jonathan; Dean, R T


    of redox-active metal ions that could catalyse oxidant formation. As a result of this decrease in antioxidant defences, and increased rate of ROS formation, it is possible that the impact of ROS increases with age. ROS are known to oxidise biological macromolecules, with proteins an important target...

  2. Ageing in communal place

    Aarhus, Rikke; Ballegaard, Stinne Aaløkke; Grönvall, Erik;


    In this paper we adopt the position that design of social media for the elderly and virtual senior communities may be informed by studying `real´senior communities. Since current research efforts target the role of social media and virtual communities for supporting seniors ageing in place, i.e. in...

  3. Bioethics and aging

    Domingo Castillo


    The purpose of this presentation is to discuss some concepts related to bioethics and ageing, specifically with regard to health and disease. Considerations on medical practice are made by referring to Kant and Heidelberg school of thought. Perception of time in the elderly and issues such as euthanasia and death are mentioned.

  4. Observer's Interface for JWST Observation Specifications

    Link, Miranda; Douglas, Robert; Moriarty, Christopher; Roman, Anthony


    In support of the launch of the James Webb Space Telescope, various teams at STScI (the Space Telescope Science Institute) have collaborated on how to re-structure the view of a an observing program within the Astronomer's Proposal Tool (APT) to accommodate for the differences between HST and JWST. For HST APT programs, the structure is visit-dominant, and there is one generic form for entering observing information that spans all instruments with their required fields and options. This can result in sometimes showing irrelevant fields to the user for a given observing goal. Also, the generation of mosaicked observations in HST requires the user to manually calculate the position of each tile within the mosaic, accounting for positional offsets and the roll of the telescope, which is a time consuming process. Now, for JWST programs in APT, the description of the observations has been segregated by instrument and mode into discrete observing templates. Each template's form allows instrument specific choices and displays of relevant information. APT will manually manage the number of visits needed to perform the observation. This is particularly useful for mosaics and dithering with JWST. For example, users will select how they would like a mosaic to be tiled at the observation level, and the visits are automatically created. In this, visits have been re-structured to be purely informational; all editing is done at the observation level. These options and concepts are illustrated to future users via the corresponding poster.

  5. Transgenerational memory effect of ageing in Drosophila.

    Burns, James G; Mery, Frederic


    Children born to older parents tend to have lower intelligence and are at higher risk for disorders such as schizophrenia and autism. Such observations of ageing damage being passed on from parents to offspring are not often considered within the evolutionary theory of ageing. Here, we show the 25% memory impairment in Drosophila melanogaster offspring solely dependent on the age of the parents and also passed on to the F2 generation. Furthermore, this parental age effect was not attributed to a generalized reduction in condition of the offspring but was specific to short-term memory. We also provide evidence implicating oxidative stress as a causal factor by showing that lines selected for resistance to oxidative stress did not display a memory impairment in offspring of old parents. The identification of the parental age-related memory impairment in a model system should stimulate integration between mechanistic studies of age-related mortality risk and functional studies of parental age effects on the fitness of future generations. PMID:20149023

  6. Ageing management in Sweden

    Since the adoption of the 1997 act of parliament concerning the abolishment of nuclear power in Sweden plant lives are no longer limited until 2010 as they were following the referendum in 1980. The Swedish Nuclear Power Inspectorate (SKI) has therefore in its most recent general regulations from 2004 introduced requirements for nuclear power plants to develop ageing management programmes which should have been in place by the end of 2005. Since SKI:s role is not to provide detailed regulations but to ensure that the licensees take the full responsibility for the safety of their plants the detailed contents of the programmes have not been stipulated by SKI. An ageing management programme should coordinate the plant efforts in other programmes such as maintenance, monitoring, inspection, environmental qualification, chemistry, periodic testing and surveillance programmes that should already exist. In this way an integrated and long term approach to these issues can be ensured and become a natural part in the overall management of the plant. To this end it is important that the ageing management programme, as all other central programmes and processes, is documented in the quality assurance system, overall management system and is included in the underlying safety analysis report of the plant. Once the ageing management programmes have been established SKI is planning to assess them specifically through a combination of inspection and document reviews during 2008 and 2009. Thereafter it is anticipated that the major regulatory effort will be concentrated to the assessment of the periodic safety reviews to determine the effectiveness of the programmes and whether further specific regulatory action is required. SKI will also continue its active involvement in national and international research efforts to improve the understanding of ageing and degradation mechanisms. (author)

  7. Perceived age as clinically useful biomarker of ageing: cohort study

    Christensen, Kaare; Thinggaard, Mikael; McGue, Matt;


    young men, and 11 older women (assessors); 1826 twins aged >or=70. MAIN OUTCOME MEASURES: Assessors: perceived age of twins from photographs. Twins: physical and cognitive tests and molecular biomarker of ageing (leucocyte telomere length). RESULTS: For all three groups of assessors, perceived age was...

  8. Adult Graduates' Negotiations of Age(ing) and Employability

    Siivonen, Päivi; Isopahkala-Bouret, Ulpukka


    In this article, we will explore Finnish adult graduates' social positioning in relation to age and ageing, and the new discursive framing of employability that is firmly expressed in national as well as in European policy agendas. Age is here understood as a social construction and ageing as a lifelong process. We will analyse our joint interview…

  9. Violence in the Dark Ages

    Thacker, R J


    A wide range of observational and theoretical arguments suggest that the universe experienced a period of heating and metal enrichment, most likely from starbursting dwarf galaxies. Using a hydrodynamic simulation we have conducted a uniquely detailed theoretical investigation of this epoch at the end of the cosmological ``dark ages''. Outflows strip baryons from pre-viralized halos with total masses $\\lesssim10{}^{10}$ M${}_\\odot$, reducing their number density and the overall star formation rate, while pushing these quantities toward their observed values. We show that the metallicity of $\\lesssim10{}^{10}$ M${}_\\odot$ objects increases with size, but with a large scatter, reproducing the metallicity-luminosity relation of dwarf galaxies. Galaxies $\\gtrsim10{}^{10}$ M${}_\\odot$ form with a roughly constant initial metallicity of 10% solar, explaining the observed lack of metal-poor disk stars in these objects. Outflows enrich roughly 20% of the simulation volume, yielding a mean metallicity of 0.3% solar, i...

  10. Unmaking old age : political and cognitive formats of active ageing.

    Lassen, A.J.; Moreira, T.


    Active ageing is a policy tool that dominates the way the ageing society has been constituted during the last decades. The authors argue that active ageing is an attempt at unmaking the concept of old age, by engaging in the plasticity of ageing in various ways. Through a document study of the different epistemes, models and forms used in the constitution of active ageing policies, the authors show how active ageing is not one coordinated set of policy instruments, but comes in different form...

  11. Aging trends -- the Philippines.

    Biddlecom, A E; Domingo, L J


    This report presents a description of the trends in growth of the elderly population in the Philippines and their health, disability, education, work status, income, and family support. The proportion of elderly in the Philippines is much smaller than in other Southeast Asian countries, such as Singapore and Malaysia. The elderly population aged over 65 years increased from 2.7% of total population in 1990 to 3.6% in 1990. The elderly are expected to comprise 7.7% of total population in 2025. The proportion of elderly is small due to the high fertility rate. Life expectancy averages 63.5 years. The aged dependency ratio will double from 5.5 elderly per 100 persons aged 15-64 years in 1990 to 10.5/100 in 2025. A 1984 ASEAN survey found that only 11% of elderly rated their health as bad. The 1990 Census reveals that 3.9% were disabled elderly. Most were deaf, blind, or orthopedically impaired. 16% of elderly in the ASEAN survey reported not seeing a doctor even when they needed to. 54% reported that a doctor was not visited due to the great expense. In 1980, 67% of men and 76% of women aged over 60 years had less than a primary education. The proportion with a secondary education in 2020 is expected to be about 33% for men and 33% for women. 66.5% of men and 28.5% of women aged over 60 years were in the formal labor force in 1990. Women were less likely to receive cash income from current jobs or pensions. 65% of earnings from older rural people was income from agricultural production. 60% of income among urban elderly was from children, and 23% was from pensions. Family support is provided to the elderly in the form of coresidence. In 1988, 68% of elderly aged over 60 years lived with at least one child. Retirement or nursing homes are uncommon. The Philippines Constitution states that families have a duty to care for elderly members. PMID:12292274

  12. [The aging of Down's Syndrome subjects].

    Fromage, B; Anglade, P


    The normal ageing of Down's Syndrome subjects is comparable to that observed in individuals who have an equivalent cognitive deficit. However it is earlier and is related to the former intellectual level and life story of the person. Before 50 years, there is no significant reduction of memory. After this age short-term memory, the speed of information processing and selective attention weaken. These changes are similar to those in older non-Down's Syndrome defective adults, giving the impression of early ageing in Down's Syndrome subjects. In terms of autonomy in everyday life, it is possible to establish an average evolutionary profile. From 60 years old, deterioration is estimated at 45% of the score obtained at 40 years, affecting in particular the skills necessary for the carrying out daily tasks (washing, dressing, feeding without assistance.). We have little knowledge of the psychiatric evolution of this people because older handicapped people are a new group in society. In the three fields of cognition, autonomy and mental health, the ageing of Down's Syndrome subjects is very sensitive to their environment. Pathological ageing of the Down's Syndrome subject is associated with the dementia syndrome that, with varying degrees, combines disorders of the cognitive functions and behavior, modifying the personality. The clinical diagnosis of dementia is difficult to establish in the Down's Syndrome subject and opinions diverge, also it is important to comply with three rules: 1) to establish an individual base line and to observe, with the help of regular evaluations, a clear change in performance; this must be confirmed by similar modifications in daily conducts; 2) the decline depends not only on the resources of the subject, but also on the demands made by environment; 3) lasting deterioration of capacities must be clearly greater than that observable in normal ageing to signify dementia. As a function of actual age, the Down's Syndrome shows early signs of

  13. Natural radioactivity, age estimation

    The life in the earth depends totally on the sun. The universe was born from great explosion, the Big Bang. Practically all the materials in the nature contain radioactive nuclides. The sources that give them origin can be categorized as: 1. Cosmogenic s 2. primordial 3. anthropogenic. The application for the first and two groups of natural radionuclides it is the age estimation. Although some of the primitive ones has application in therapy of oncological patient. 1: The three groups of age estimation methods, for nuclear phenomenons are: 1. Measure of the radioactive decline of the primitive isotopes, by accumulation of stable isotopes. 2. use of the descendants of radioactive isotopes of the families of the Uranium or of the Th. 3. Measure of the cosmogenic s isotopes

  14. Aging management of Cirus

    Cirus, a 40 MWt tank type research reactor located at the Bhabha Atomic Research Centre, is in operation since 1960. In Cirus, heavy water is used as moderator, demineralized light water as primary coolant and natural uranium metal as fuel. The average availability factor had been about 70% till the year 1990 where after it started decreasing due to frequent problems with equipment and components. Systematic aging studies were therefore undertaken to assess the condition of structures, systems and components. Based on these studies, refurbishing requirements were identified and a detailed plan was drawn up for refurbishing. The reactor was shut down in October 1997 for execution of refurbishing jobs. A summary is presented of the results of aging studies and the refurbishing plans. Details of core unloading to facilitate refurbishing and some of the important jobs in the primary coolant system relating to pressure testing of primary coolant pipelines and repairs to identified leaky sections are discussed. (author)

  15. Aging, exercise, and attention.

    Hawkins, H L; Kramer, A F; Capaldi, D


    The authors investigated the relationship among aging, attentional processes, and exercise in 2 experiments. First they examined age differences on 2 attentional tasks, a time-sharing task and an attentional flexibility task. Young adults alternated attention between 2 sequenced tasks more rapidly and time-shared the processing of 2 tasks more efficiently than older adults. They then investigated the effects of aerobic exercise on the same 2 attentional tasks in older adults. Following the 10-week exercise program, older exercisers showed substantially more improvement in alternation speed and time-sharing efficiency than older controls. Interestingly, this exercise effect was specific to dual-task processing. Both groups of subjects showed equivalent effects on single-task performance. These results indicate that aerobic exercise can exert a beneficial influence on the efficiency of at least 2 different attentional processes in older adults. PMID:1466833

  16. The Great Ice Age

    Ray, Louis L.


    The Great Ice Age, a recent chapter in the Earth's history, was a period of recurring widespread glaciations. During the Pleistocene Epoch of the geologic time scale, which began about a million or more years ago, mountain glaciers formed on all continents, the icecaps of Antarctica and Greenland were more extensive and thicker than today, and vast glaciers, in places as much as several thousand feet thick, spread across northern North America and Eurasia. So extensive were these glaciers that almost a third of the present land surface of the Earth was intermittently covered by ice. Even today remnants of the great glaciers cover almost a tenth of the land, indicating that conditions somewhat similar to those which produced the Great Ice Age are still operating in polar and subpolar climates.

  17. Constipation in old age.

    Gallagher, Paul


    The prevalence of constipation increases with age. However, constipation is not a physiological consequence of normal ageing. Indeed, the aetiology of constipation in older people is often multifactorial with co-morbid diseases, impaired mobility, reduced dietary fibre intake and prescription medications contributing significantly to constipation in many instances. A detailed clinical history and physical examination including digital rectal examination is usually sufficient to uncover the causes of constipation in older people; more specialized tests of anorectal physiology and colonic transit are rarely required. The scientific evidence base from which to develop specific treatment recommendations for constipation in older people is, for the most part, slim. Constipation can be complicated by faecal impaction and incontinence, particularly in frail older people with reduced mobility and cognitive impairment; preventative strategies are important in those at risk.

  18. Blood rheology and aging

    Başkurt, Oğuz K.; Simmonds, Michael J. ; Meiselman, Herbert J.


    Journal of Geriatric Cardiology (2013) 10: 291301 ©2013 JGC All rights reserved;; | Journal of Geriatric Cardiology Review  Open Access  Blood rheology and aging Michael J. Simmonds1, Herbert J. Meiselman2, Oguz K. Baskurt3 1Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Gold Coast, QLD 4222, Australia 2Department of Physiology and Biophysics, Keck School of Medicine, University of S...

  19. Communication and Aging

    Yorkston, Kathryn M.; Bourgeois, Michelle S.; Baylor, Carolyn R.


    Interpersonal communication has been described as a critical tool for life adjustment, linking people to their environment.1 When communication disorders are present these links can be easily broken. Communication disorders form a diverse group of conditions that vary in terms of type, severity, and co-occurrence with other symptoms that limit mobility, vision, endurance, or cognition. Although communication disorders affect people of all ages, the prevalence and complexity of these condition...

  20. Anthropocene Age Wicked Challenges

    Edgeman, Rick; Wu, Zhaohui


    weather events, drought, and desertification; threatened food supplies; water pollution, air pollution, and soil contamination; and the connection of these to disease, violence, and terrorism. Wicked challenges are discussed in relation to enterprise excellence, sustainability, resilience and robustness......Grand global challenges, including wicked human caused or influenced ones key to sustainability, characterize the Anthropocene Age. Among these are climate change driven by increased methane and CO2 in the atmosphere; consequent global warming and increasing intensity and incidence of extreme...

  1. The aging lung

    Lowery EM; Brubaker AL; Kuhlmann E; Kovacs EJ


    Erin M Lowery,1 Aleah L Brubaker,2 Erica Kuhlmann,1 Elizabeth J Kovacs31Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine at Loyola University Medical Center, 2Loyola University Stritch School of Medicine, 3Department of Surgery, Loyola University Medical Center, Maywood, IL, USAAbstract: There are many age-associated changes in the respiratory and pulmonary immune system. These changes include decreases in the volume of the thoracic cavity, reduced lung volume...

  2. Diabetes in the Aged

    Grobin, Wulf


    In keeping with the already known high prevalence of diabetes among residents of the Jewish Home for the Aged, Toronto, annual screening disclosed an average incidence of 25.5% of abnormal glucose tolerance (two-hour post-glucose blood sugars above 140 mg./100 ml.) in residents not known to be diabetic. Forty-five (47%) of the 94 residents with abnormal screening values were considered subsequently to be diabetic according to our criteria. Long-term follow-up, particularly of 81 residents initially normoglycemic in 1964-5, confirmed that the natural course of glucose tolerance in this population was one of progressive deterioration. By contrast, improvement amounting to remission has been demonstrated in nine out of 20 residents several years after they had been declared diabetic, and is thought to have been induced by dietotherapy. Moderate hyperglycemia per se did not cause symptoms in these almost always keto-resistant and usually aglycosuric aged diabetics, who often claimed they felt better when hyperglycemic. Hypoglycemia was an ever present danger when anti-diabetic medication was used; it was the main reason for undertreatment. So far, data from our long-term study have not shown morbidity to be markedly increased in the diabetics, and mortality was found to be evenly distributed among diabetic and non-diabetic male residents. However, in the females there was a clear correlation between mortality rate and the diminished glucose tolerance. What may appear as overdiagnosis of diabetes in the aged is recommended in the hope that early institution of dietary treatment will delay the development of clinical diabetes and the need for anti-diabetic agents. This, in turn, would prevent iatrogenic hypoglycemia. It would also reduce the severity and frequency of spontaneous hypoglycemia which, we believe, occurs more commonly in the early phase of diabetes in the aged than is generally realized. PMID:5476778

  3. Old age and poverty

    Vuković Drenka


    Full Text Available The process of demographic changes in Serbia is followed by discussions on the need to provide safety at old age and solve the problems of poverty and social exclusion of older citizens. In the current state there are no mechanisms that guarantee an adequate life standard at old age, the consequence of which is a high poverty rate, deteriorating health and limited access to social programs. The results of the Survey on life standard from 2002 and 2007 show that poverty among population in general and pensioners has decreased, while the poverty risk among people older than 65 has increased twice. The restrictive methods of the reforms cause a change in the relation between the pensions and the earnings, so that more and more pensioners receive below average, i.e. minimal pensions. Not all old people are covered by pension insurance so that a significant number (around 400.000 does not have a safe monthly income at all. The state program of financial aid is of modest size and does not provide help to all of the poor. Welfare aid decreases the risk of poverty, but it do not guarantee an adequate level of material security at old age. The low level of minimal and average pensions, the decline of participation in the average earnings and the strict criteria of the social security system have brought to awareness the necessity of 'social pensions' and various help and support programs for the elderly. .

  4. The little ice age

    Grove, J.M.


    The Little Ice Age, a period of glacier expansion in alpine regions that began sometime between the twelfth and sixteenth centuries and lasted until late in the nineteenth century, was recorded not only in glacial features dated by geologic techniques but also in historical documents such as field sketches, land values, and weather records, especially in the Alps. Indirect evidence of its impact in other parts of the world includes the records of sea-ice extent near Iceland and Greenland, the fate of the Viking settlements in Greenland, and many other suggestions that the climate was colder in the recent past than it is today. Jean Grove's book is an authoritative, superbly documented, and excellently written summary of the abundant evidence of climatic change during the last few centuries in the context of broader climatic variations of the last 10,000 years. This summary provides a much-needed perspective for considering the magnitude and frequency of natural climatic variations in the past, given predictions for the future. In the final chapter, Grove notes that natural climatic variations, including another minor ice age, might be expected in the future but at the end of the Little Ice Age coincided with the increased burning of fossil fuels during the industralization of Europe and North America. This coincidence does indeed suggest that modern scientists already have had a significant impact on the global climate.

  5. [Resilience in old age].

    Cárdenas-Jiménez, Andrea; López-Díaz, Alba L


    The aim of this study was to characterise and analyse articles published on resilience and old-age from 1990-2006. After a systematic search of five databases (Academic Search Premier-Ebsco Host, Medline, Psyc Articles, Ovid and Science Direct) 33 pieces of literature were included in the analysis. The selected articles had 31 different definitions of resilience, from eight disciplines, mainly health-related fields. It was also found that the research studied the association of resilience with individual (68 variables) and social/environmental factors (17 variables); the most frequent were age and health self-perception. Cultural and religious values were of special interest amongst the latter variables. The literature review demonstrated that resilience in old age is a topic having increasing research interest; this has been linked to various individual, social and cultural factors. However, this is a rapidly developing area that requires that a unified definition be established and that a theoretical and intervention model be created. PMID:22031004

  6. Space age. Final report



    Space age had its world premiere at the large-screen Spaceport Theater at Cape Canaveral/Kennedy Spaceport. The first program was screened for invited guests who, that morning, also witnessed a launch of the Space Shuttle. Since that mission carried the first Japanese astronaut, it was a nice tie-in to the substantial co-production participation of space age by NHK Japan. A special press conference for the series and a twenty-minute preview reel was screened for journalists who were also at the Cape for the shuttle launch. Numerous first-hand newspaper articles were generated. CNN ran part of the preview reel. The first episode in the series, `The Quest for Planet Mars,` then ran twice a day for a week, prior to the Public Broadcasting Service broadcast on an Imax format screen at the Spaceport theater. The program was seen by thousands of visitors. Space age also had a special premier at the National Academy of Sciences in Washington, DC with some 400 special guests, including scientists and government agency representatives.

  7. Thermal-aging evaluation of on site aged cast duplex stainless steel

    Cast duplex stainless steel was widely used for main coolant pipe in pressurized water reactors, they can suffer a loss of toughness after long-term thermal-aging. To evaluate mechanical properties of such as thermal-aged materials was investigated in laboratory using accelerated aged materials. In addition, to investigate the degradation mechanism, micro-structural behaviors were also investigated. According to such as laboratory data, main cause of degradation of these materials was considered ferrite hardening by spinodal decomposition and G-phase precipitation in the ferrite phase. In this study, thermal-aging evaluation has been performed using service aged elbow pipe in PWR plant, aged at 320℃ for 196,500h. Thermal-aging were evaluated using atom-probe analysis, scanning transmission electron microscope, and micro-Vickers hardness measurement. And then those parameters were compared accelerated thermal-aged materials. As a result, micro Vickers hardness of ferrite in service material (SCS14A), HV(0.025) was 616-630. Since micro Vickers hardness of un-aged ferrite phase is about HV(0.025)=300 in commercial SCS14A, the increasing of ferrite hardness during aging was 300. Cr-rich and Fe-rich regions were observed in the ferrite phase using Atom-probe analysis. In addition, Ni, Si and Mo clustering were also observed in the ferrite phase. So the ferrite phase was hardened caused by these micro-structural changes. Micro Vickers hardness of austenite phase, HV (0.025) was 155-180. Since micro Vickers hardness of un-aged austenite phase is about HV (0.025)=180-200, and no micro-structural change was observed in the austenite phase, so no change was observed in the austenite phase during aging. To compare the micro Vickers hardness of ferrite in service and accelerated materials using activation energy, Q=100kJ/mol, the ferrite hardness of in service material was very low rather than predictive line. This seems the activation energy was too conservative. (author)

  8. Ageing changes in the eye

    Salvi, S M; Akhtar, S; Currie, Z


    Ageing changes occur in all the structures of the eye causing varied effects. This article attempts to review the parameters of what is considered within the “normal limits” of ageing so as to be able to distinguish those conditions from true disease processes. Improving understanding of the ageing changes will help understand some of the problems that the ageing population faces.

  9. Immune Dysfunction in Aged Horses.

    McFarlane, Dianne


    The aging process in people is associated with changes in adaptive and innate immune responses. Similar changes occur in aged horses. Age-related progressive impairment in the ability to respond to pathogen challenge and an increased inflammatory reactivity may predispose geriatric horses to many diseases of old age. Specific recommendations for immune modification of older horses, including an age-appropriate vaccination schedule, are not currently available. In addition, the effect of old age on risk of infectious disease is poorly documented. More work is needed to better understand the interactions of age on immunity, vaccine response, and disease risk in horses. PMID:27329495

  10. Age aspects of habitability

    Safonova, M.; Murthy, J.; Shchekinov, Yu. A.


    A `habitable zone' of a star is defined as a range of orbits within which a rocky planet can support liquid water on its surface. The most intriguing question driving the search for habitable planets is whether they host life. But is the age of the planet important for its habitability? If we define habitability as the ability of a planet to beget life, then probably it is not. After all, life on Earth has developed within only ~800 Myr after its formation - the carbon isotope change detected in the oldest rocks indicates the existence of already active life at least 3.8 Gyr ago. If, however, we define habitability as our ability to detect life on the surface of exoplanets, then age becomes a crucial parameter. Only after life had evolved sufficiently complex to change its environment on a planetary scale, can we detect it remotely through its imprint on the atmosphere - the so-called biosignatures, out of which the photosynthetic oxygen is the most prominent indicator of developed (complex) life as we know it. Thus, photosynthesis is a powerful biogenic engine that is known to have changed our planet's global atmospheric properties. The importance of planetary age for the detectability of life as we know it follows from the fact that this primary process, photosynthesis, is endothermic with an activation energy higher than temperatures in habitable zones, and is sensitive to the particular thermal conditions of the planet. Therefore, the onset of photosynthesis on planets in habitable zones may take much longer time than the planetary age. The knowledge of the age of a planet is necessary for developing a strategy to search for exoplanets carrying complex (developed) life - many confirmed potentially habitable planets are too young (orbiting Population I stars) and may not have had enough time to develop and/or sustain detectable life. In the last decade, many planets orbiting old (9-13 Gyr) metal-poor Population II stars have been discovered. Such planets had had

  11. Mathematical Model of Age Aggression

    Golovinski, P. A.


    We formulate a mathematical model of competition for resources between representatives of different age groups. A nonlinear kinetic integral-differential equation of the age aggression describes the process of redistribution of resources. It is shown that the equation of the age aggression has a stationary solution, in the absence of age-dependency in the interaction of different age groups. A numerical simulation of the evolution of resources for different initial distributions has done. It ...

  12. Dominant perceptions on the age

    Komatina Slavica


    Contemporary developed society, despite the fact that it is constantly and intensively ageing, is characterized by deeply rooted numerous negative stereotypes on old people and old age as a life period. The study of dominant perceptions on the age of Belgrade population takes not only the universal character of negative connotation of old age into consideration, but also the concrete unfavorable social context. The delicate problematic of stereotypes on old age and old people has been analyze...

  13. [Relationships among self concept, perception of aging and physical aging].

    Lee, Y H; Kim, M S; Choi, Y H


    Although everyone grows old, perception about the aging process and aging as measured physiologically vary widely. Perceptions of aging have psychologically influence on physical aging. This study was to examine the relationships between, self-concept, perception of aging, and physical aging in the elderly and to contribute to the theory development which may direct nursing intervention to promote well-being of the aged. Subjects were 70 women residents of a nursing home for the elderly in Seoul. Data collection was done from May 15 to June 15, 1988 using interview schedules and mechanical instruments. The instruments were selected items from the Health Self Concept Scale developed by Jacox and Stewart for self concept, and Secord and Jourad's Body Cathexis Scale and Osgood's Semantic Differential Scale for perception of aging. Physical aging was measured by mechanical instruments, inspection, questions, and palpation. The data were analysed for mean, t-test, ANOVA, and Pearson Correlation Coefficient using an S.P.S.S computerized program. The results of the analysis were as follows. 1. The mean level of self concept for the subject group was 16.97 (SD = +/- 6.17) in a range from 6-30. The mean level of perception of aging was 39.6. (SD = +/- 6.51) in a range from 13-65. The mean level of physical aging was 14.09 (SD = +/- 2.05) in a range from 8-40. 2. Relationships among self-concept, perception of aging, and physical aging. 1) There was a positive relationship between self-concept and perception of aging (r = 0.4461, p = 0.000). 2) There was a negative relationship between physical aging and perception of aging (r = -0.2975, p = 0.006). 3) There was a tendency toward a negative relationship between physical aging and self-concept, but not a significant relationship (r = -0.1033, p = 0.197). 3. 1) No general characteristic variables were related to self concept. 2) The general characteristic variable related to the level of perception of aging was religion (t = 4

  14. AAO Observer - August 2011 Edition

    Brough, Sarah


    This edition of the Australian Astronomical Observatory Observer contains articles on the commissioning of the new SAMI instrument giving the first hexabundle galaxy spectra; galaxy parameter variations across and through the 6dFGS Fundamental Plane; an introduction to the new Dragonfly stellar interferometer; an update on the RAdial VElocity (RAVE) survey at half a million spectra; the Magellanic Quasars Survey; the Integrated Photonic Spectrograph's first look at the heart of the Scorpion; using AAOMega to measure the age of the young open cluster IC2602; making MANIFEST fibres for the Giant Magellan Telescope and a Voyage through Filaments of Galaxies. The Observer also contains thoughts on diversity in the astronomy community and reports on the recent Supernovae and their Host Galaxies conference and the 2011 Science Meets Parliament. In addition there are the usual features of the AUSGO Corner, Epping News and Letter from Coona.

  15. Fetal age estimation using MSCT scans of deciduous tooth germs.

    Minier, Marie; Maret, Delphine; Dedouit, Fabrice; Vergnault, Marion; Mokrane, Fathima-Zohra; Rousseau, Hervé; Adalian, Pascal; Telmon, Norbert; Rougé, Daniel


    Evaluation of fetal age is an essential element in many fields such as anthropology, odontology, paleopathology, and forensic sciences. This study examines the correlation between fetal age, femoral diaphyseal length (considered as the gold standard), and deciduous tooth germs of fetuses aged 22 to 40 weeks amenorrhea (WA) based on computed tomography (MSCT) reconstructions. Qualitative and quantitative studies of femoral and deciduous tooth germ lengths were performed on 81 fetuses (39 females and 42 males). R software was used for statistical analyses. Intra-observer and inter-observer variabilities and the interclass correlation coefficient (ICC) were calculated. Correlation coefficients (R (2)) and linear regression equations were calculated. Intra- and inter-observer variabilities were very satisfactory (intra-observer ICC ≥ 0.96, inter-observer ICC ≥ 0.95). Femoral length was significantly correlated with age (R (2) = 0.9). The correlation coefficient between age and height, width, and dental volume was R (2) ≥ 0.73. Tooth germs were good indicators of fetal age. Our method appears to be reliable and reproducible, and the results of this study agreed with those of the literature. The dental formula provided a precise estimation of fetal age between 25 and 32 WA. Tooth germs were reliable indicators of fetal age, and multislice computed tomography was shown to be an innovative and reliable technology for this purpose. PMID:23828625

  16. Dry aging of beef; Review.

    Dashdorj, Dashmaa; Tripathi, Vinay Kumar; Cho, Soohyun; Kim, Younghoon; Hwang, Inho


    The present review has mainly focused on the specific parameters including aging (aging days, temperature, relative humidity, and air flow), eating quality (flavor, tenderness and juiciness), microbiological quality and economic (shrinkage, retail yields and cost) involved beef dry aging process. Dry aging is the process where beef carcasses or primal cuts are hanged and aged for 28 to 55 d under controlling environment conditions in a refrigerated room with 0° to 4 °C and with relative humidity of 75 to 80 %. However there are various opinions on dry aging procedures and purveyors of such products are passionate about their programs. Recently, there has been an increased interest in dry aging process by a wider array of purveyors and retailers in the many countries. Dry aging process is very costly because of high aging shrinkage (6 to15 %), trims loss (3 to 24 %), risk of contamination and the requirement of highest grades meat with. The packaging in highly moisture-permeable bag may positively impact on safety, quality and shelf stability of dry aged beef. The key effect of dry aging is the concentration of the flavor that can only be described as "dry-aged beef". But the contribution of flavor compounds of proteolysis and lipolysis to the cooked dry aged beef flavor is not fully known. Also there are limited scientific studies of aging parameters on the quality and palatability of dry aged beef. PMID:27200180

  17. [Normal aging of frontal lobe functions].

    Calso, Cristina; Besnard, Jérémy; Allain, Philippe


    Normal aging in individuals is often associated with morphological, metabolic and cognitive changes, which particularly concern the cerebral frontal regions. Starting from the "frontal lobe hypothesis of cognitive aging" (West, 1996), the present review is based on the neuroanatomical model developed by Stuss (2008), introducing four categories of frontal lobe functions: executive control, behavioural and emotional self-regulation and decision-making, energization and meta-cognitive functions. The selected studies only address the changes of one at least of these functions. The results suggest a deterioration of several cognitive frontal abilities in normal aging: flexibility, inhibition, planning, verbal fluency, implicit decision-making, second-order and affective theory of mind. Normal aging seems also to be characterised by a general reduction in processing speed observed during neuropsychological assessment (Salthouse, 1996). Nevertheless many cognitive functions remain preserved such as automatic or non-conscious inhibition, specific capacities of flexibility and first-order theory of mind. Therefore normal aging doesn't seem to be associated with a global cognitive decline but rather with a selective change in some frontal systems, conclusion which should be taken into account for designing caring programs in normal aging. PMID:27005339

  18. Hydra, a powerful model for aging studies

    Tomczyk, Szymon; Fischer, Kathleen; Austad, Steven; Galliot, Brigitte


    Cnidarian Hydra polyps escape senescence, most likely due to the robust activity of their three stem cell populations. These stem cells continuously self-renew in the body column and differentiate at the extremities following a tightly coordinated spatial pattern. Paul Brien showed in 1953 that in one particular species, Hydra oligactis, cold-dependent sexual differentiation leads to rapid aging and death. Here, we review the features of this inducible aging phenotype. These cellular alterations, detected several weeks after aging was induced, are characterized by a decreasing density of somatic interstitial cell derivatives, a disorganization of the apical nervous system, and a disorganization of myofibers of the epithelial cells. Consequently, tissue replacement required to maintain homeostasis, feeding behavior, and contractility of the animal are dramatically affected. Interestingly, this aging phenotype is not observed in all H. oligactis strains, thus providing a powerful experimental model for investigations of the genetic control of aging. Given the presence in the cnidarian genome of a large number of human orthologs that have been lost in ecdysozoans, such approaches might help uncover novel regulators of aging in vertebrates. PMID:26120246

  19. ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

    Pierpaola Davalli


    Full Text Available The aging process worsens the human body functions at multiple levels, thus causing its gradual decrease to resist stress, damage, and disease. Besides changes in gene expression and metabolic control, the aging rate has been associated with the production of high levels of Reactive Oxygen Species (ROS and/or Reactive Nitrosative Species (RNS. Specific increases of ROS level have been demonstrated as potentially critical for induction and maintenance of cell senescence process. Causal connection between ROS, aging, age-related pathologies, and cell senescence is studied intensely. Senescent cells have been proposed as a target for interventions to delay the aging and its related diseases or to improve the diseases treatment. Therapeutic interventions towards senescent cells might allow restoring the health and curing the diseases that share basal processes, rather than curing each disease in separate and symptomatic way. Here, we review observations on ROS ability of inducing cell senescence through novel mechanisms that underpin aging processes. Particular emphasis is addressed to the novel mechanisms of ROS involvement in epigenetic regulation of cell senescence and aging, with the aim to individuate specific pathways, which might promote healthy lifespan and improve aging.

  20. Age estimation from physiological changes of teeth: A reliable age marker?

    Nishant Singh


    Full Text Available Background: Age is an essential factor in establishing the identity of a person. Teeth are one of the most durable and resilient part of skeleton. Gustafson (1950 suggested the use of six retrogressive dental changes that are seen with increasing age. Aim: The aim of the study was to evaluate the results and to check the reliability of modified Gustafson′s method for determining the age of an individual. Materials and Methods: Total 70 patients in the age group of 20-65 years, undergoing extraction were included in this present work. The ground sections of extracted teeth were prepared and examined under the microscope. Modified Gustafson′s criteria were used for the estimation of age. Degree of attrition, root translucency, secondary dentin deposition, cementum apposition, and root resorption were measured. A linear regression formula was obtained using different statistical equations in a sample of 70 patients. Results: The mean age difference of total 70 cases studied was ±2.64 years. Difference of actual and calculated age was significant and was observed at 5% level of significance, that is, t-cal > t-tab (t-cal = 7.72. P < 0.05, indicates that the results were statistically significant. Conclusion: The present study concludes that Gustafson′s method is a reliable method for age estimation with some proposed modifications.

  1. Aging of Pentaerythritol Tetranitrate (PETN)

    Foltz, M F


    crystalline surface irregularities may cause a decrease in surface area over time due to smoothing of contact points and sintering. PETN has been found to contain a number of impurities, including homologues, pentaerythryl ethers with a mixture of hydroxyl and nitrate functional groups, and organic salts, that can alter its physical and chemical properties. (5) The processes of sublimation/recrystallization and surface diffusion are important processes that can cause changes in PETN crystal morphology, particle size distribution and specific surface area. Sublimation feeds a process called Ostwald ripening, which involves the spontaneous growth of larger crystals from those of smaller size. This process proceeds with age regardless of storage conditions unless the crystals are treated to retard growth. The coarsening mechanisms include Ostwald ripening, 'sintering', and surface diffusion. The latter has not been experimentally observed, but a molecular modeling approach has attempted to investigate this phenomenon theoretically. (6) Threshold test fire, particle size distribution, specific surface area, thermal analysis, chemical analysis, powder compact specific surface area and density are approaches that have been used in the attempt to assess changes attributable to aging of PETN, with varying results. The biggest problem lies in the aging mechanism itself, which likely influences small changes in morphology, both internal and external, and particle size distribution changes on a scale too small to reliably monitor. Other aspects, such as subtle changes in density profiles within pressed powder compacts, may be beyond the capability of current technology to assess. Crystal growth significant enough to affect the PETN particle size distribution is expected to impact detonator performance. (7) Factors relevant to stabilizing particle size growth include crystal morphology, powder surface area and particle size distribution; crystal density and internal defects

  2. Unmaking old age: political and cognitive formats of active ageing

    Lassen, Aske Juul; Moreira, Tiago


    different epistemes, models and forms used in the constitution of active ageing policies, the authors show how active ageing is not one coordinated set of policy instruments, but comes in different formats. In the WHO, active ageing configures individual lifestyle in order to expand the plasticity of ageing......, based on epidemiological and public health conventions. In the EU, active ageing reforms the retirement behaviour of populations in order to integrate the plasticity of ageing into the institutions, based on social gerontological and demographic conventions. These conventional arrangements are cognitive...

  3. Molecular Inflammation: Underpinnings of Aging and Age-related Diseases

    Chung, Hae Young; Cesari, Matteo; Anton, Stephen; Marzetti, Emanuele; Giovannini, Silvia; Seo, Arnold Young; Carter, Christy; Yu, Byung Pal; Leeuwenburgh, Christiaan


    Recent scientific studies have advanced the notion of chronic inflammation as a major risk factor underlying aging and age-related diseases. In this review, low-grade, unresolved, molecular inflammation is described as an underlying mechanism of aging and age-related diseases, which may serve as a bridge between normal aging and age-related pathological processes. Accumulated data strongly suggest that continuous (chronic) up-regulation of pro-inflammatory mediators (e.g., TNF-α, IL-1β, 6, CO...

  4. School Starting Age and the Crime-Age Profile

    Landersø, Rasmus; Nielsen, Helena Skyt; Simonsen, Marianne


    This paper uses register-based data to investigate the effects of school starting age on crime. Through this, we provide insights into the determinants of crime-age profiles. We exploit that Danish children typically start first grade in the calendar year they turn seven, which gives rise to a...... discontinuity in school starting age for children born around New Year. Our analysis speaks against a simple invariant crime-age profile as is popular in criminology: we find that higher school starting age lowers the propensity to commit crime at young ages. We also find effects on the number of crimes...

  5. The pituitary - Aging and spaceflown rats

    Hymer, W. C.; Grindeland, R. E.


    Decrements in growth hormone (GH) release we observed in two spaceflight experiments and four tail-suspended rat studies mimic age-associated changes in the mammalian pituitary GH system seen by Meites and others. The spaceflight data suggest that formation of high molecular weight bioactive disulfide-linked aggregates of the 20 and 22K monomeric GH forms may be reduced in microgravity, thereby, reducing target tissue activity. Correlative studies to confirm spaceflight as a model for pituitary GH system aging should include: (1) investigation of mechanisms of intracellular hormone packaging, (2) consequences to biological activity of the hormone molecule, and (3) study of intracellular microtubule dynamics.

  6. The Abnormal Choroidal Vessels in Aged Patients

    Shizhou Huang; Feng Wen; Dezheng Wu; Guangwei Luo; Caijiao Liu


    Background: To show the abnormal choroidal vessels in aged patients with indocyanine-green angiography (ICGA).Methods: ICGA was performed in 350 patients with TOPCON TRC-50IA fundus camera.The images were recorded and retrospectively reviewed.Results: Five aged patients out of 350 cases were found to have abnormal choroidalvessels. The incidence was 1.43%. The abnormal choroidal vessels showed round- shapet,focal enlargement, abnormal shape and entrance, satellite appearance, and vascularloops. These might be due to congenital abnormality of choroid.Conclusion: ICGA could be used to observe the abnormal choroidal vessels.

  7. The new electricity age

    Weinhold, Michael; Willnow, Klaus


    A sustainable energy system requires optimal integration of all components resulting in an integrated energy system. To setup the integrated energy system three steps have to be completed: 1. Optimal selection and allocation of the Energy Mix 2. Efficiency increase along all steps of the energy conversion chain 3. Holistic optimization across infrastructures and across regions using Smart Grid Technologies Due to greater complexity caused by growing demand for electricity and decentralized generation only end-to-end intelligence from power plants via networks to end-use applications, so-called smart grid technologies will enable the integrated energy system and thus the New Electricity Age.

  8. The Age of Precision Cosmology

    Chuss, David T.


    In the past two decades, our understanding of the evolution and fate of the universe has increased dramatically. This "Age of Precision Cosmology" has been ushered in by measurements that have both elucidated the details of the Big Bang cosmology and set the direction for future lines of inquiry. Our universe appears to consist of 5% baryonic matter; 23% of the universe's energy content is dark matter which is responsible for the observed structure in the universe; and 72% of the energy density is so-called "dark energy" that is currently accelerating the expansion of the universe. In addition, our universe has been measured to be geometrically flat to 1 %. These observations and related details of the Big Bang paradigm have hinted that the universe underwent an epoch of accelerated expansion known as Uinflation" early in its history. In this talk, I will review the highlights of modern cosmology, focusing on the contributions made by measurements of the cosmic microwave background, the faint afterglow of the Big Bang. I will also describe new instruments designed to measure the polarization of the cosmic microwave background in order to search for evidence of cosmic inflation.

  9. The pedagogicalization of ageing societies

    Fristrup, Tine


    Transformations' in' the' age'profile'of' a'population' are' a' response' to' political' and' economic' structures' and' in' relation' to' public'services'older'people'become'a'burden'to'the'younger'work) ing'people.'The'construction'of'a'social'problem'in'relation'to'popu) lation' ageing' becomes......'way'of'controlling'the'processes'of'subjectification'in'old' age'as'the'socialization'of'an'ageing'person'in'relation'to'the'disci) plining' of' population' ageing:' becoming' a' subject' to' active' and' healthy'ageing.'The'future'of'ageing'societies'depends'on'the'plas) ticity' of' the' individual' performance' underlying' people’s' personal' responsibility......' a' social' pedagogical' problem' involving' a' focus' on' social' pedagogical' interventions' throughout' the' life' course.'In'order'to'shape'the'future'of'society,'the'perspective'on' ageing'and'old'age'has'shifted'from'being'a'determined'process'to' becoming' a'modifiable' process' focusing' on...

  10. Randomized-controlled observation of naolibao in improvement of memory impairment in aged people with yin deficiency of liver and kidney%脑力宝改善肝肾阴虚证老年人记忆障碍的随机对照观察

    王健; 李方莲


    BACKGROUND: There are many reports on treatment of senile memory impairment with huperzine A, aniracetam, ginkgobiloba, etc. But, a strict double-blind and double-dummy design is deficit during experiment.OBJECTIVE: With cognition, symptoms of yin deficiency of liver and kidney and memory taken as observed indexes, double-blind and doubledummy method was used to observe the therapeutic effects of Chinese drug naolibao on senile memory impairmentof yin deficiency of liver and kidney. DESIGN: Prospective clinical experiment with randomized controlled double-blind and double-dummy method was designed. SETTING: Department of Neurology of Affiliated Hospital with Changchun College of Chinese Medicine, Department of Medicament of 2nd Clinical Hospital Affiliated to Jilin University.PARTICIPANTS: Totally 80 cases of memory impairment were from the clinic of Department of Neurology of affiliated Hospital with Changchun College of Chinese Medicine from April to December 2000. They were aged varied from 40 to 75 years, with mild non-constant poor memory, differentiated as yin deficiency of liver and kidney and diagnosed as questionable dementia in Chinese medicine, scored as 0 or 0.5 according to Clinical Dementia Assessment Scale (CDAS) and their integrals were > 17 (illiteracy) or > 20 (elementary-school educated) or > 23 (juniorschool educated) and 17(文盲)或>20(小学)或>23(初中以上)和的疗效判定标准,治疗后症状积分下降与治疗前症状平均积分值比较,显效:≥2/3,有效1/3~2/3,无效≤1/3.认知及记忆功能疗效判定采用尼莫地平法计算公式[(治疗后积分-治疗前积分)÷治疗前积分]×100%,临床控制≥85%,显效≥50%,有效≥20%,无效≤20%.主要观察指标:①两组肝肾阴虚证治疗前后变化比较.②两组治疗前后肝肾阴虚证症状积分比较.③两组记忆功能各项指标评定结果比较.④显效病例随访结果.⑤不良事件和副反应.结果:脑力宝组43例和脑复康组37

  11. Check valves aging assessment

    In support of the NRC Nuclear Plant Aging Research (NPAR) program, the Oak Ridge National Laboratory (ORNL) has carried out an assessment of several check value diagnostic monitoring methods, in particular, those based on measurements of acoustic emission, ultrasonics, and magnetic flux. The evaluations have focussed on the capabilities of each method to provide information useful in determining check valve aging and service wear effects, check valve failures, and undesirable operating modes. This paper describes the benefits and limitations associated with each method and includes recent laboratory and field test data, including data obtained from the vendors who recently participated in a comprehensive series of tests directed by a nuclear industry users group. In addition, as part of the ORNL Advanced Diagnostic Engineering Research and Development Center (ADEC), two novel nonintrusive monitoring methods were developed that provide several unique capabilities. These methods, based on external ac- an dc-magnetic monitoring are also described. None of the examined methods could, by themselves, monitor both the instantaneous position and motion of check valve internals and valve leakage; however, the combination of acoustic emission monitoring with one of the other methods provides the means to determine vital check valve operational information

  12. [Feeding and aging].

    Sánchez Zaplana, Isabel; Maestre González, Elena


    Aging is characterized by an increase in relative population of 65 years and older, and can say that, in our country, it is a phenomenon demographic, political, social and health. Several studies have shown that the nutritional status of the general population and the elderly, in particular, is a valid indicator to predict longevity and quality of life of this group of people. The World Health Organization (who) pointed out that the elderly population is a group nutritionally very vulnerable as a result of anatomical and physiological changes associated with aging. Between 35-40 of the elderly has some kind of altered nutrition or malnutrition: protein or protein-energy malnutrition, selective deficiency of vitamins and minerals, inadequate water intake, obesity, etc. The best way to promote the quality of life and prevent disease is a proper diet, also called healthy eating, adapted to the special circumstances which older persons may present without forgetting gastronomy is not incompatible with health. In this article, some tips are also available for preparing and cooking food, as well as culinary strategies to introduce them in the daily menu. PMID:23909217

  13. Antioxidants in the Canine Model of Human Aging

    Dowling, Amy L. S.; Head, Elizabeth


    Oxidative damage can lead to neuronal dysfunction in the brain due to modifications to proteins, lipids and DNA/RNA. In both human and canine brain, oxidative damage progressively increases with age. In the Alzheimer’s disease (AD) brain, oxidative damage is further exacerbated, possibly due to increased deposition of beta-amyloid (Aβ) peptide in senile plaques. These observations have led to the hypothesis that antioxidants may be beneficial for brain aging and AD. Aged dogs naturally develo...

  14. Age-dependent small-animal internal radiation dosimetry

    XIE, Tianwu; Zaidi, Habib


    Rats at various ages were observed to present with different radiosensitivity and bioavailability for radiotracers commonly used in preclinical research. We evaluated the effect of age-induced changes in body weight on radiation dose calculations. A series of rat models at different age periods were constructed based on the realistic four-dimensional digital rat whole-body (ROBY) computational model. Particle transport was simulated using the MCNPX Monte Carlo code. Absorbed fractions (AFs) a...

  15. Smoking and cognitive change from age 11 to age 80

    Deary, Ian J; Pattie, Alison; M. D. Taylor; Whiteman, Martha C; Starr, John M; Lawrence J Whalley


    Age related cognitive decline affects people’s quality of life and their ability to live independently. A recent review stated, "[we] are aware of no studies on the relationship between smoking and cognitive decline associated with normal aging or studies of the effect of smoking on cognition in normally aging individuals." Some previous studies examined smoking in relation to pathological cognitive aging, but lacked cognitive data before the initiation of smoking, and used crude clinical cog...

  16. Ageing, Health and Life Satisfaction of the Oldest Old: An Analysis for Germany

    Gwozdz, Wencke; Sousa-Poza, Alfonso


    This analysis uses data from the German Socio-Economic Panel and the Survey on Health, Ageing and Retirement in Europe to assess the effect of ageing and health on the life satisfaction of the oldest old (defined as 75 and older). We observe a U-shaped relationship between age and levels of life satisfaction for individuals aged between 16 and 65.…

  17. Changing Attitudes towards Ageing and the Aged amongst Psychology Students

    Fonseca, Antonio; Goncalves, Daniela; Martin, Ignacio


    Society is ageing. In Europe, the ageing of the population is a recurrent and discussed theme. The impact of the ageing of the population is varied and transversal in different fields. The increase in the number of elderly people implies an increase in the levels of dependence and, consequently, more sanitary, physical, and human resources. Also,…

  18. Impairment of age estimation from faces in Alzheimer's disease.

    Moyse, Evelyne; Bastin, Christine; Salmon, Eric; Brédart, Serge


    A prerequisite for any function in social cognition is the perception and processing of social cues. Age estimation is a skill that is used in everyday life and is fundamental in social interactions. This study evaluated whether facial age estimation is impaired in patients with mild to moderate Alzheimer's disease (AD). The current age of faces is known to have an impact on age estimation, and therefore stimuli belonging to different age groups (young, middle-aged, and older adults' faces) were used. As expected, an impairment of age estimation from faces was observed in mild to moderate AD patients. However, the profile of impairment depended on the age of faces and stage of the disease. Mild AD patients presented difficulties mainly in assessing the age of middle-aged adults. In moderate disease stage, these difficulties also affected the age estimation of young adult faces. Interestingly, AD patients remained relatively good at estimating the age of older adults' faces, compared to healthy controls. PMID:25589725

  19. Aging management assessment of type B transportation packages

    The condition of a physical system such as a radioactive materials transportation package can change as it ages. The degree to which aging effects are identified, prevented or mitigated will depend on the types of inspections and maintenance performed on the critical components of the system. Routine inspections and maintenance may not address degradation mechanisms that are difficult to observe and can act over long periods of time. Aging management is a systematic effort to ensure that the system performs as designed over its entire service life and that degradation mechanisms do not prematurely end the service life. The Nuclear Waste Management Division (NWMD) of Ontario Power Generation (OPG) has developed an Aging Management Procedure and began performing aging management assessments on its Type B(U) packages. This paper discusses the Procedure and briefly describes the aging management assessment performed on the Roadrunner Transportation Package to demonstrate a practical application of the aging management process

  20. Towards age/rotation/magnetic activity relation with seismology

    Mathur, Savita


    The knowledge of stellar ages directly impacts the characterization of a planetary system as it puts strong constraints on the moment when the system was born. Unfortunately, the determination of precise stellar ages is a very difficult task. Different methods can be used to do so (based on isochrones or chemical element abundances) but they usually provide large uncertainties. During its evolution a star goes through processes leading to loss of angular momentum but also changes in its magnetic activity. Building rotation, magnetic, age relations would be an asset to infer stellar ages model independently. Several attempts to build empirical relations between rotation and age (namely gyrochronology) were made with a focus on cluster stars where the age determination is easier and for young stars on the main sequence. For field stars, we can now take advantage of high-precision photometric observations where we can perform asteroseismic analyses to improve the accuracy of stellar ages. Furthermore, the variab...

  1. Physical activity, quality of life and medication in aging: differences between age and gender

    Lilian Teresa Bucken Gobbi


    Full Text Available Studies have shown an inverse relationship between physical activity level (PAL, quality of life (QoL and use of medications in the elderly. The objective of this study was to analyze possible relationships and differences between PAL, QoL and use of medications in the elderly. A total of 192 subjects (≥ 60 years were selected by stratified random sampling according to census sector. The following assessment instruments were used: a Modified Baecke Questionnaire for older adults, b Medical Outcomes Study – 36-Item Short Form Health Survey, and c Sociodemographic and Health Factors Questionnaire. Descriptive statistics and parametric and nonparametric tests were used (p < 0.05. a With respect to chronological age, significant differences between groups were only observed for PAL, with G1 (60-69 years being more active than the other groups. b With respect to gender irrespective of age, analysis showed a difference in QoL and in the number of medications, with men reporting better perceived QoL and using fewer medications. c With respect to gender but considering chronological age, differences in PAL, QoL and medication use were observed between genders for specific age groups. In conclusion, in the elderly a PAL is low, declines even more during advanced age and is higher in men than in women during the first decade of old age, and b men report better perceived QoL and use fewer medications than women.

  2. Color change of composite resins subjected to accelerated artificial aging

    Denise Cremonezzi Tornavoi


    Conclusions: All composite resins presented unacceptable color changes after 382 h of aging and different composite resins with same hue, presented different colors before being subjected to the aging process (B2 and C2 and after (B2. It was also observed color difference within a group of the same composite resin and same hue.

  3. Radical Change: Books for Youth in a Digital Age

    Dresang, Eliza T.


    "Radical Change: Books for Youth in a Digital Age" (Dresang, 1999) is a landmark work that examines ways in which young readers are affected by the Digital Age. The impetus for the book grew out of Eliza Dresang's observation that printed books with nonlinear, interactive qualities appeal strongly to contemporary children. She noted that…

  4. Low vigorous physical activity at ages 15, 19 and 27

    Suppli, Camilla Hiul; Due, Pernille; Henriksen, Pia Elena Wichmann;


    The present study examines (i) if the level of vigorous physical activity (VPA) at age 15 predicts low VPA at ages 19 and 27 and (ii) whether the observed prediction pattern differs by childhood socio-economic position (SEP). In this way, prediction analyses are applied to study tracking behaviour....

  5. Ataxia rating scales are age-dependent in healthy children

    Brandsma, Rick; Spits, Anne H.; Kuiper, Marieke J.; Lunsing, Roelinka J.; Burger, Huibert; Kremer, Hubertus P.; Sival, Deborah A.


    AIM: To investigate ataxia rating scales in children for reliability and the effect of age and sex. METHOD: Three independent neuropaediatric observers cross-sectionally scored a set of paediatric ataxia rating scales in a group of 52 healthy children (26 males, 26 females) aged 4 to 16 years (mean

  6. Uruguay - Surface Weather Observations

    National Oceanic and Atmospheric Administration, Department of Commerce — Surface weather observation forms for 26 stations in Uruguay. Period of record 1896-2005, with two to eight observations per day. Files created through a...

  7. Lightship Monthly Observations

    National Oceanic and Atmospheric Administration, Department of Commerce — Daily Weather Observations (Monthly Form 1001) from lightship stations in the United States. Please see the 'Surface Weather Observations (1001)' library for more...

  8. Surface Weather Observations Hourly

    National Oceanic and Atmospheric Administration, Department of Commerce — Standard hourly observations taken at Weather Bureau/National Weather Service offices and airports throughout the United States. Hourly observations began during...

  9. Regional National Cooperative Observer

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA publication dedicated to issues, news and recognition of observers in the National Weather Service Cooperative Observer program. Issues published regionally...

  10. Monthly Weather Observations

    National Oceanic and Atmospheric Administration, Department of Commerce — Monthly Weather Observations (Form 1001) is a set of historical manuscript records for the period 1893-1948. In order to fill in the observation gap prior to the...

  11. Role of Carbonyl Modifications on Aging-Associated Protein Aggregation

    Tanase, Maya; Urbanska, Aleksandra M.; Zolla, Valerio; Clement, Cristina C.; Huang, Liling; Morozova, Kateryna; Follo, Carlo; Goldberg, Michael; Roda, Barbara; Reschiglian, Pierluigi; Santambrogio, Laura


    Protein aggregation is a common biological phenomenon, observed in different physiological and pathological conditions. Decreased protein solubility and a tendency to aggregate is also observed during physiological aging but the causes are currently unknown. Herein we performed a biophysical separation of aging-related high molecular weight aggregates, isolated from the bone marrow and splenic cells of aging mice and followed by biochemical and mass spectrometric analysis. The analysis indicated that compared to younger mice an increase in protein post-translational carbonylation was observed. The causative role of these modifications in inducing protein misfolding and aggregation was determined by inducing carbonyl stress in young mice, which recapitulated the increased protein aggregation observed in old mice. Altogether our analysis indicates that oxidative stress-related post-translational modifications accumulate in the aging proteome and are responsible for increased protein aggregation and altered cell proteostasis.

  12. Effect of cholecystokinin on experimental neuronal aging

    Xiao-Jiang Sun; Qin-Chi Lu; Yan Cai


    AIM: To observe the effect of cholecystokinin (CCK) on lipofusin value, neuronal dendrite and spine ultrastructure, and total cellular protein during the process of experimental neuronal aging.METHODS: Experimental neuronal aging study model was established by NBA2cellular serum-free culture method. By using single irtracellular lipofusin value from microspectrophotometry,morphology of neuronal dendrites and spines from the scanner electron microscopy, and total cellular protein as the indexes of experimental neuronal aging, we observed the effect of CCK8 on the process of experimental neuronal aging.RESULTS: Under the condition of serum-free culture,intracellular fluorescence value (%) increased with the extension of culture time (1 d 8.51±3.43; 5 d 10.12±3.03;10 d 20.54±10.3; 15 d 36.88±10.49; bP<0.01). When CCK was added to serum-free culture medium, intracellular lipofusin value (%) decreased remarkably after consecutive CCK reaction for 10 and 15 d (control 36.88±10.49; 5 d 32.03±10.01; 10 d 14.37±5.55; 15 d 17.31±4.80; bP<0.01).As the time of serum-free culturing was prolonged, the number of neuronal dendrite and spine cells decreased.The later increased in number when CCK8 was added. CCK8 could improve the total cellular protein in the process of experimental neuronal aging.CONCLUSION: CCK8 may prolong the process of experimental neuronal aging by maintaining the structure and the number of neuronal dendrite and spine cells and changing the total cellular protein.

  13. Employment Age Discrimination on Women



    Employment age discrimination against women is not an unusual phenomenon in China.Through describing the present situation and negative effect of this phenomenon,this paper claims laws are very important weapon to eliminate age discrimination against women.

  14. Aging changes in the senses

    ... ency/article/004013.htm Aging changes in the senses To use the sharing features on this page, ... enable JavaScript. As you age, the way your senses (hearing, vision, taste, smell, touch) give you information ...

  15. Aging changes in body shape

    ... and both sexes. Height loss is related to aging changes in the bones, muscles, and joints. People ... lifetime. Your lifestyle choices affect how quickly the aging process takes place. Some things you can do ...

  16. Aging changes in hormone production

    ... that produce hormones are controlled by other hormones. Aging also changes this process. For example, an endocrine ... produce the same amount at a slower rate. AGING CHANGES The hypothalamus is located in the brain. ...

  17. Large for gestational age (LGA)

    ... this page: // Large for gestational age (LGA) To use the sharing features on this page, please enable JavaScript. Large for gestational age means that a fetus or ...

  18. MedlinePlus: Healthy Aging

    ... Health screening - women - over 65 Related Health Topics Exercise for Seniors Nutrition for Seniors Seniors' Health National Institutes of Health The primary NIH organization for research on Healthy Aging is the National Institute on Aging Languages ...

  19. Personality Plasticity After Age 30

    Terracciano, Antonio; Costa, Paul T.; McCrae, Robert R.


    Rank-order consistency of personality traits increases from childhood to age 30. After that, different summaries of the literature predict a plateau at age 30, or at age 50, or a curvilinear peak in consistency at age 50. These predictions were evaluated at group and individual levels using longitudinal data from the Guilford-Zimmerman Temperament Survey and the Revised NEO Personality Inventory over periods of up to 42 years. Consistency declined toward a non-zero asymptote with increasing time-interval. Although some scales showed increasing stability after age 30, the rank-order consistencies of the major dimensions and most facets of the Five-Factor Model were unrelated to age. Ipsative stability, assessed with the California Adult Q-Set, was also unrelated to age. These data strengthen claims of predominant personality stability after age 30. PMID:16861305

  20. Organizational Climate for Successful Aging.

    Zacher, Hannes; Yang, Jie


    Research on successful aging at work has neglected contextual resources such as organizational climate, which refers to employees' shared perceptions of their work environment. We introduce the construct of organizational climate for successful aging (OCSA) and examine it as a buffer of the negative relationship between employee age and focus on opportunities (i.e., beliefs about future goals and possibilities at work). Moreover, we expected that focus on opportunities, in turn, positively predicts job satisfaction, organizational commitment, and motivation to continue working after official retirement age. Data came from 649 employees working in 120 companies (M age = 44 years, SD = 13). We controlled for organizational tenure, psychological climate for successful aging (i.e., individuals' perceptions), and psychological and organizational age discrimination climate. Results of multilevel analyses supported our hypotheses. Overall, our findings suggest that OCSA is an important contextual resource for successful aging at work. PMID:27458405

  1. Cognition and brain functional aging

    Hui-jie LI


    Full Text Available China has the largest population of elderly adults. Meanwhile, it is one of the countries showing fastest aging speed in the world. Aging processing is always companied with a series of brain structural and functional changes, which result in the decline of processing speed, working memory, long-term memory and executive function, etc. The studies based on functional magnetic resonance imaging (fMRI found certain aging effects on brain function activation, spontaneous activity and functional connectivity in old people. However, few studies have explored the brain functional curve during the aging process while most previous studies explored the differences in the brain function between young people and old people. Delineation of the human brain functional aging curve will promote the understanding of brain aging mechanisms and support the normal aging monitoring and early detection of abnormal aging changes. doi: 10.3969/j.issn.1672-6731.2014.03.005

  2. Aging changes in the breast

    ... this page: // Aging changes in the breast To use the sharing ... chap 18. Minaker KL. Common clinical sequelae of aging. In: Goldman L, Schafer AI, eds. Goldman's Cecil ...

  3. Aging changes in the lungs

    ... this page: // Aging changes in the lungs To use the sharing ... out (exhaled). Watch this video about: Gas exchange AGING CHANGES IN YOUR BODY AND THEIR AFFECTS ON ...

  4. Aging changes in body shape

    ... this page: // Aging changes in body shape To use the sharing ... and both sexes. Height loss is related to aging changes in the bones, muscles, and joints. People ...

  5. 7 Steps to Aging Well

    ... Issue Past Issues Special Section 7 Steps to Aging Well Past Issues / Winter 2007 Table of Contents ... Exercise: A Guide from the National Institute on Aging is a publication from NIA that has strength, ...

  6. Aging changes in the kidneys

    ... this page: // Aging changes in the kidneys and bladder To use ... in the reproductive system can affect bladder control. Aging Changes and Their Effects on the Kidneys and ...

  7. Aging changes in hormone production

    ... this page: // Aging changes in hormone production To use the sharing ... that produce hormones are controlled by other hormones. Aging also changes this process. For example, an endocrine ...

  8. Personality plasticity after age 30.

    Terracciano, Antonio; Costa, Paul T; McCrae, Robert R


    Rank-order consistency of personality traits increases from childhood to age 30. After that, different summaries of the literature predict a plateau at age 30, or at age 50, or a curvilinear peak in consistency at age 50. These predictions were evaluated at group and individual levels using longitudinal data from the Guilford-Zimmerman Temperament Survey and the Revised NEO Personality Inventory for periods of up to 42 years. Consistency declined toward a nonzero asymptote with increasing time interval. Although some scales showed increasing stability after age 30, the rank-order consistencies of the major dimensions and most facets of the Five-Factor Model were unrelated to age. Ipsative stability, assessed with the California Adult Q-Set, also was unrelated to age. These data strengthen claims of predominant personality stability after age 30. PMID:16861305

  9. Observing in school geometry

    Zupan, Karmen


    Observing is an important process in learning geometry. In the first part of the thesis observing is considered from a psychological perspective: the Gestalt theory, its history, the distribution of gestalt qualities, as well as various studies and theories of templates. The observing process is considered also from the didactic point of view by means of the van Hiele’s theory of levels of geometric reasoning. Since colours also influence observing, a list of advices for teachers about using ...

  10. Learning by observing

    Efe Postalci


    We introduce a network formation model based on the idea that individuals engage in production (or decide to participate in an action) depending on the similar actions of the people they observe in a society. We differentiate from the classical models of participation by letting individuals to choose, non cooperatively, which agents to observe. Observing behavior of others is a costly activity but provides benefits in terms of reduction in cost of production for the observing agent, which we ...

  11. Cloning of observables

    Ferraro, Alessandro; Galbiati, Matteo; Paris, Matteo G. A.


    We introduce the concept of cloning for classes of observables and classify cloning machines for qubit systems according to the number of parameters needed to describe the class under investigation. A no-cloning theorem for observables is derived and the connections between cloning of observables and joint measurements of noncommuting observables are elucidated. Relationships with cloning of states and non-demolition measurements are also analyzed.

  12. Log-concave Observers

    Henningsson, Toivo; Åström, Karl Johan


    The Kalman filter is the optimal state observer in the case of linear dynamics and Gaussian noise. In this paper, the observer problem is studied when process noise and measurements are generalized from Gaussian to log-concave. This generalization is of interest for example in the case where observations only give information that the signal is in a given range. It turns out that the optimal observer preserves log-concavity. The concept of strong log-concavity is ...

  13. Nutrition and aging.

    Noel, Mary; Reddy, Mohan


    Nutritional concerns are common among older adults seen in the primary care office. The food pyramid for people over the age of 70 years is a useful starting point for discussions about what reasonably healthy older adults should be eating and drinking. If there is a decline in the ability to perform IADLs or if there is a decrease in appetite or the discovery of unintended weight loss, careful assessment followed by targeted interventions may improve health outcomes and the quality of life. Restrictive diets are often not well tolerated, especially by frail older adults. Dietary recommendations blending the elements of the pyramid and the essential components of accepted medical nutritional therapy that are most consistent with the patient's lifelong eating patterns are most likely to succeed. PMID:16140121

  14. Analyzing an Aging ISS

    Scharf, R.


    The ISS External Survey integrates the requirements for photographic and video imagery of the International Space Station (ISS) for the engineering, operations, and science communities. An extensive photographic survey was performed on all Space Shuttle flights to the ISS and continues to be performed daily, though on a level much reduced by the limited available imagery. The acquired video and photo imagery is used for both qualitative and quantitative assessments of external deposition and contamination, surface degradation, dynamic events, and MMOD strikes. Many of these assessments provide important information about ISS surfaces and structural integrity as the ISS ages. The imagery is also used to assess and verify the physical configuration of ISS structure, appendages, and components.

  15. Observed Infant Reactions during Live Interparental Conflict

    Du Rocher Schudlich, Tina D.; White, Clare R.; Fleischhauer, Emily A.; Fitzgerald, Kelly A.


    Associations between interparental conflict and infant reactions were examined. Infants' history of exposure to interparental conflict and infant reactive temperament were examined as moderators. A community sample of 74 infants, aged 6-14 months, participated with their parents. Behavioral observations were made of parents' marital conflict and…

  16. Glycoconjugate changes in aging and age-related diseases.

    Ando, Susumu


    The significance of glycosphingolipids and glycoproteins is discussed in their relation to normal aging and pathological aging, aging with diseases. Healthy myelin that looks stable is found to be gradually degraded and reconstructed throughout life for remodeling. An exciting finding is that myelin P0 protein is located in neurons and glycosylated in aging brains. In pathological aging, the roles of glycosphingolipids and glycoproteins as risk factors or protective agents for Alzheimer's and Parkinson's diseases are discussed. Intensive studies have been performed aiming to remove the risks from and to restore the functional deficits of the brain. Some of them are expected to be translated to therapeutic means. PMID:25151390

  17. Radioactive sampler observation device

    When an object of observation is a fuel rod and if a specimen in a fuel pool is small, it takes much labor for the observation and micro-observation images at a high ratio can not be displayed. A pipe for containing an observing camera in a water-sealed state, a jack capable of adjusting the focus of the observation camera by remote control and a horizontal bed capable of controlling the position of the observation camera for observing the specimen are disposed on a rail formed on lead block shielding walls. The magnification ratio for the observation can be increased by exchanging a die for securing the specimen and a lens, and a transparent acrylic resin plate, or a transparent lead-incorporated glass plate is joined to the bottom of the pipe. Since the sampled specimen can be observed as it is irrespective of the shape or the size of the specimen to be observed, danger of radiation exposure caused such as upon cutting, transportation or fabrication of the radioactive specimen can be reduced. Further, observation underwater can be conducted by the water sealing treatment of the pipe for the observing camera. (N.H.)

  18. Precise age estimation from different ageing structures in the striped snakehead, Channa striata (Bloch,1793, collected from the river Ganga

    Salman Khan


    Full Text Available In Channa striata (N=156; TL=17-60cm sampled from the river Ganga, the annuli laid on different ageing structures such as otoliths (whole and sectioned, scales, opercular bone and vertebrae were observed for age estimation. Standard procedures were followed to prepare and study the age structures. Age estimates obtained from different hard structures were analysed to calculate the parameters for precise age estimation viz., APE, CV and PA. The sectioned otoliths showed the highest (89.9% percentage of agreement between readers while least average percent error (1.20% and coefficient of variation (3.81% values between two readers. Thus sectioned otoliths were considered to be the most suitable method for estimating age in C. striata. When sectioned otoliths were compared with other bony structures, the highest percent agreement and lowest average percent error and coefficient of variation values were found between sectioned otoliths and whole otoliths age estimates.

  19. Farmer Productivity at Various Ages

    Tauer, Loren W.


    The productivity of farmers at six different age cohorts was computed by estimating production functions using 1987 census data. The results suggest that farmers of different ages operate with slightly different technologies and use various inputs at different efficiencies. Compared with previous 1978 estimates, the productivity of middleaged farmers appears to be even greater than the productivity of younger and older farmers. The average age of U.S. farmers exceeds the age of highest produc...

  20. Aging and Functional Brain Networks

    Tomasi, Dardo; Volkow, Nora D.


    Aging is associated with changes in human brain anatomy and function and cognitive decline. Recent studies suggest the aging decline of major functional connectivity hubs in the “default-mode” network (DMN). Aging effects on other networks, however, are largely unknown. We hypothesized that aging would be associated with a decline of short- and long-range functional connectivity density (FCD) hubs in the DMN. To test this hypothesis we evaluated resting-state datasets corresponding to 913 hea...

  1. The clinical pharmacology of ageing

    Swift, C G


    The ageing of populations and individuals continues to be as vital, yet to some extent as neglected, a topic in pharmacology and therapeutics as was first realised about 30 years ago. In parallel with the realisation of the predicted demographic shifts in both the developed and developing world, there have since been major developments in the basic biological concepts of ageing, in the physiology of ageing, in the study of pathogenetic mechanisms underlying a variety of age-associated disorde...

  2. Lithuanian Population Aging Factors Analysis

    Agnė Garlauskaitė; Rasa Zabarauskaitė


    The aim of this article is to identify the factors that determine aging of Lithuania’s population and to assess the influence of these factors. The article shows Lithuanian population aging factors analysis, which consists of two main parts: the first describes the aging of the population and its characteristics in theoretical terms. Second part is dedicated to the assessment of trends that influence the aging population and demographic factors and also to analyse the determinants of the agin...

  3. Personality Plasticity After Age 30

    Terracciano, Antonio; Costa, Paul T.; McCrae, Robert R.


    Rank-order consistency of personality traits increases from childhood to age 30. After that, different summaries of the literature predict a plateau at age 30, or at age 50, or a curvilinear peak in consistency at age 50. These predictions were evaluated at group and individual levels using longitudinal data from the Guilford-Zimmerman Temperament Survey and the Revised NEO Personality Inventory over periods of up to 42 years. Consistency declined toward a non-zero asymptote with increasing t...

  4. The Effect of Age on Attention Level: A Comparison of Two Age Groups.

    Lufi, Dubi; Segev, Shahar; Blum, Adi; Rosen, Tal; Haimov, Iris


    In the present study, a computerized test was used to compare the attention level of a group of healthy older participants aged 75 with that of a group of students aged 31. The second part of the study examined only the older participants and sought to discover how three measures of lifestyle were related to measures of attention. The results showed that the young group performed better on measures of attention. No differences between the two age groups were found on measures of impulsivity and on four measures of sustained attention. A discriminant function analysis found that reaction time and standard deviation of reaction time can explain 87.50% of the variance in both groups. The older participants' answers to the lifestyle questions showed that variables of attention correlated significantly with time spent watching television and reading. The results indicate that attention level declines with age; however, no decline was observed on measures of impulsivity and sustained attention. PMID:26537543

  5. The changing understanding of ageing. Part 1: Evaluating ageing theories and studies

    Dennis F. Lawler


    Full Text Available This is the first of three discussions on emerging views of ageing, its derivation, and ageing-related diseases. To offer a context for the series, this first report briefly reviews several major early and recent theoretical debates. Arguments for and against several well-known ageing theories are presented for their veterinary relevance, including mutation, pleiotropy, reproduction-longevity trade-offs, oxygen metabolism and ageing as a genomically programmed product of natural selection. Additionally, the author presents commonly encountered problems when reading to interpret laboratory and population studies of ageing, offering busy clinicians a perspective on evaluating complex papers that analyse ageing-related data. Included among these problems are categorising intrinsic and extrinsic diseases, contrasts between laboratory-based and population-based observations, over-generalising research outcomes, short-term and long-term studies, and theoretical treatises. Central ideas of these discussions include why post-reproductive life span is relatively common among animals, the nature of age-related diseases relative to stochastic or programmed origins and the disease-related implications.

  6. Non-financial determinants of the retirement age

    Vermeer, C.A.F.


    This dissertation examines the importance of non-financial determinants for the individual retirement age. Recent increases in statutory retirement ages around the world point to the relevance of this issue. Financial incentives alone cannot fully explain observed retirement behavior. Chapter 2 examines the possible relevance of insights from behavioral economics and social norms for retirement and concludes that defaults, reference points and social norms are likely explanations for observed...

  7. Pathophysiology of ageing, longevity and age related diseases

    Santoni Angela


    Full Text Available Abstract On April 18, 2007 an international meeting on Pathophysiology of Ageing, Longevity and Age-Related Diseases was held in Palermo, Italy. Several interesting topics on Cancer, Immunosenescence, Age-related inflammatory diseases and longevity were discussed. In this report we summarize the most important issues. However, ageing must be considered an unavoidable end point of the life history of each individual, nevertheless the increasing knowledge on ageing mechanisms, allows envisaging many different strategies to cope with, and delay it. So, a better understanding of pathophysiology of ageing and age-related disease is essential for giving everybody a reasonable chance for living a long and enjoyable final part of the life.

  8. [Vitamin E in the aged].

    Pentimone, F; del Corso, L; Laghi, G


    Aging is a multifactorial process still incompletely known. The role of oxidative damage to cell membranes, as an important phase of the process, is underlined by the recent literature. We emphasize the value of vitamin E as an antioxidant agent supplied by suitable diets in middle age and by cheap tablets in the aged. PMID:8001337

  9. Modern biological theories of aging

    These proceedings contain 30 papers grouped under the headings of: Theories of aging: A perspective; Evolution of life span in placental mammals; Developmentally programmed aging; Free-radical damage; Error catastrophe; DNA Damage and repair; and Organ systems as pacemakers of aging

  10. Is the Age Problem Resolved?

    Ali Akbar Navabi; Nematollah Riazi


    The cosmological, astrophysical, and nucleocosmochronological methods for estimating the age of the universe and the corresponding uncertainties are comparatively studied in the present paper.We are led to the conclusion that the newmeasurements of cosmological parameters, and the recent estimates of the age of globular clusters have led to the gradual disappearance of the age problem from the arena of modern cosmology.

  11. The temporal scaling of Caenorhabditis elegans ageing

    Stroustrup, Nicholas; Anthony, Winston E.; Nash, Zachary M.; Gowda, Vivek; Gomez, Adam; López-Moyado, Isaac F.; Apfeld, Javier; Fontana, Walter


    The process of ageing makes death increasingly likely, involving a random aspect that produces a wide distribution of lifespan even in homogeneous populations. The study of this stochastic behaviour may link molecular mechanisms to the ageing process that determines lifespan. Here, by collecting high-precision mortality statistics from large populations, we observe that interventions as diverse as changes in diet, temperature, exposure to oxidative stress, and disruption of genes including the heat shock factor hsf-1, the hypoxia-inducible factor hif-1, and the insulin/IGF-1 pathway components daf-2, age-1, and daf-16 all alter lifespan distributions by an apparent stretching or shrinking of time. To produce such temporal scaling, each intervention must alter to the same extent throughout adult life all physiological determinants of the risk of death. Organismic ageing in Caenorhabditis elegans therefore appears to involve aspects of physiology that respond in concert to a diverse set of interventions. In this way, temporal scaling identifies a novel state variable, r(t), that governs the risk of death and whose average decay dynamics involves a single effective rate constant of ageing, kr. Interventions that produce temporal scaling influence lifespan exclusively by altering kr. Such interventions, when applied transiently even in early adulthood, temporarily alter kr with an attendant transient increase or decrease in the rate of change in r and a permanent effect on remaining lifespan. The existence of an organismal ageing dynamics that is invariant across genetic and environmental contexts provides the basis for a new, quantitative framework for evaluating the manner and extent to which specific molecular processes contribute to the aspect of ageing that determines lifespan.

  12. Radiochemical aging of an epoxy network

    This thesis is to give a better understanding of the radiochemical aging of a thermoset resin under gamma irradiation. The conditions of aging are gamma irradiation under air with a dose rate of 2 kGy/h at 120 C. The requested lifetime is four years, it means a dose of 70 MGy. The first step of this work was the choice of a resistive epoxy resin. This choice was made thanks to the literature data. The high glass transition temperature and the high amount of aromatic groups were the main criteria of the final choice. After this choice, thermal and mechanical properties were followed under thermal and radiochemical aging: i) under thermal aging, after 600 hours at 220 C, the glass transition temperature remained unchanged. But, from a mechanical point of view, properties at break dramatically decreased. This embrittlement was assigned to a critical oxidized layer. The thickness of this layer was estimated about 30 μm. ii) the same kind of embrittlement was observed under radiochemical aging. Moreover, it appeared a decrease of the glass transition temperature when increasing the dose of irradiation. This indicates that the main degradation mechanism is chain scission under anaerobic atmosphere. We, then, proposed a mechanistic model associated with a kinetic model to predict the evolution of the glass transition temperature depending on the irradiation conditions. Parameters of the kinetic model were determined by solid NMR and ESR experiments. Comparison between experimental and calculated values at 120 C is satisfactory, a global good agreement was found. (author)

  13. Age effects on explicit and implicit memory

    Emma eWard


    Full Text Available It is well documented that explicit memory (e.g., recognition declines with age. In contrast, many argue that implicit memory (e.g., priming is preserved in healthy aging. For example, priming on tasks such as perceptual identification is often not statistically different in groups of young and older adults. Such observations are commonly taken as evidence for distinct explicit and implicit learning/memory systems. In this article we discuss several lines of evidence that challenge this view. We describe how patterns of differential age-related decline may arise from differences in the ways in which the two forms of memory are commonly measured, and review recent research suggesting that under improved measurement methods, implicit memory is not age-invariant. Formal computational models are of considerable utility in revealing the nature of underlying systems. We report the results of applying single and multiple-systems models to data on age effects in implicit and explicit memory. Model comparison clearly favours the single-system view. Implications for the memory systems debate are discussed.

  14. Regulation of a Hemodynamics Adaptation to Ageing

    Astakhov A.A.


    Full Text Available The aim of the investigation is to study a scheme implementation of the vegetative supply of the hemodynamics adaptive reaction connected with ageing. It should be evaluated with hemodynamic parameter variability. Materials and Methods. 489 healthy people have been divided into 2 age groups: 329 at the age of 20—44 years and 160 at the age of 45—65 years. The variability values of an average arterial pressure have been recorded. R—R-interval, the highest volume of the heart and the peripheral vessels pulsation amplitudes have been observed as well. The researchers have carried out a spectral analysis on the plane of complex frequencies with a spectral density capacity assessment according to the four regulatory ranges. Results. The received data allows to assess the regulation mechanisms of such parameters as the highest volume and microvessels pulsation amplitude in different age groups. Moreover, it is possible to figure out the cardiac rhythm and arterial pressure regulation mechanisms considering a probability of the oscillation analysis of the most low-frequency range.

  15. Olive Oil and the Hallmarks of Aging

    Lucía Fernández del Río


    Full Text Available Aging is a multifactorial and tissue-specific process involving diverse alterations regarded as the “hallmarks of aging”, which include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intracellular communication. Virtually all these hallmarks are targeted by dietary olive oil, particularly by virgin olive oil, since many of its beneficial effects can be accounted not only for the monounsaturated nature of its predominant fatty acid (oleic acid, but also for the bioactivity of its minor compounds, which can act on cells though both direct and indirect mechanisms due to their ability to modulate gene expression. Among the minor constituents of virgin olive oil, secoiridoids stand out for their capacity to modulate many pathways that are relevant for the aging process. Attenuation of aging-related alterations by olive oil or its minor compounds has been observed in cellular, animal and human models. How olive oil targets the hallmarks of aging could explain the improvement of health, reduced risk of aging-associated diseases, and increased longevity which have been associated with consumption of a typical Mediterranean diet containing this edible oil as the predominant fat source.

  16. Observation of online communities

    Nørskov, Sladjana V.; Rask, Morten


    This paper addresses the application of observation to online settings with a special focus on observer roles. It draws on a study of online observation of a virtual community, i.e. an open source software (OSS) community. The paper examines general and specific advantages and disadvantages of the...... observer roles in online settings by relating these roles to the same roles assumed in offline settings. The study suggests that under the right circumstances online and offline observation may benefit from being combined as they complement each other well. Quality issues and factors important to elicit...... trustworthy observational data from online study settings, such as OSS communities, are discussed. A proposition is made concerning how threats to credibility and transferability in relation to online observation (i.e. lack of richness and detail, risk of misunderstandings) can be diminished, while...

  17. Asteroseismic age determination for dwarfs and giants

    Aguirre, V Silva


    Asteroseismology can make a substantial contribution to our understanding of the formation history and evolution of our Galaxy by providing precisely determined stellar properties for thousands of stars in different regions of the Milky Way. We present here the different sets of observables used in determining asteroseismic stellar properties, the typical level of precision obtained, the current status of results for ages of dwarfs and giants and the improvements than can be expected in the near future in the context of Galactic archaeology.

  18. Asteroseismic age determination for dwarfs and giants

    Silva Aguirre, V.; Serenelli, A. M.


    Asteroseismology can make a substantial contribution to our understanding of the formation history and evolution of our Galaxy by providing precisely determined stellar properties for thousands of stars in different regions of the Milky Way. We present here the different sets of observables used ...... determining asteroseismic stellar properties, the typical level of precision obtained, the current status of results for ages of dwarfs and giants and the improvements than can be expected in the near future in the context of Galactic archaeology....

  19. Ageing management for research reactors

    During the past several years, ageing of research reactor facilities continues to be an important safety issue. Despite the efforts exerted by operating organizations and regulatory authorities worldwide to address this issue, the need for an improved strategy as well as the need for establishing and implementing a systematic approach to ageing management at research reactors was identified. This paper discusses, on the basis of the IAEA Safety Standards, the effect of ageing on the safety of research reactors and presents a proactive strategy for ageing management. A systematic approach for ageing management is developed and presented together with its key elements, along with practical examples for their application. (author)

  20. Age determination and geological studies

    Two hundred and eight potassium-argon age determinations carried out on Canadian rocks and minerals are reported. Each age determination is accompanied by a description of the rock and mineral concentrate used; brief interpretative comments regarding the geological significance of each age are also provided where possible. The experimental procedures employed are described in brief outline and the constants used in the calculation of ages are listed. Two geological time-scales are reproduced in tabular form for ready reference and an index of all Geological Survey of Canada K-Ar age determinations published in this format has been prepared using NTS quadrangles as the primary reference

  1. Technical approach to aging management

    Systematic and effective control of age-related degradation of safety-related components, systems, and structures in nuclear power plants (NPPs) is an important challenge to plant operators. Several data bases, available to provide guidance on aging management, are summarized. However, the ultimate consideration is: How effectively is aging management being implemented at individual plants? Illustrated here is a specific strategy that served to develop the technical data base for the Nuclear Plant Aging Research Program. The strategy is comprehensive, systematic, and adaptable. Effective aging management at NPPs could be facilitated by a parallel strategy. The elements of a strategy are suggested

  2. Skin aging and oxidative stress

    Sayeeda Ahsanuddin


    Full Text Available Skin aging occurs through two main pathways, intrinsic and extrinsic. These pathways have significant interaction in contributing to the aging phenotype, which includes skin laxity, wrinkling, pigmentation irregularities, and the appearance of neoplastic skin lesions. Here, we review the critical role that oxidative stress plays in skin aging, including its effects on signaling pathways involved in skin matrix formation and degradation, proteasome activity, as well as DNA structure. Furthermore, we discuss the recent literature surrounding the prevention and treatment of skin aging. Although current research is suggestive of the role of antioxidants in anti-aging skin therapies, further research is much needed to explore its role in humans.

  3. Contrasting neural effects of aging on proactive and reactive response inhibition

    Bloemendaal, Mirjam; Zandbelt, Bram; Wegman, Joost; Nieuwerth-van de Rest, Ondine; Cools, Roshan; Aarts, Esther


    Two distinct forms of response inhibition may underlie observed deficits in response inhibition in aging. We assessed whether age-related neurocognitive impairments in response inhibition reflect deficient reactive inhibition (outright stopping) or also deficient proactive inhibition (anticipator

  4. BOOK REVIEW: Observational Cosmology Observational Cosmology

    Howell, Dale Andrew


    Observational Cosmology by Stephen Serjeant fills a niche that was underserved in the textbook market: an up-to-date, thorough cosmology textbook focused on observations, aimed at advanced undergraduates. Not everything about the book is perfect - some subjects get short shrift, in some cases jargon dominates, and there are too few exercises. Still, on the whole, the book is a welcome addition. For decades, the classic textbooks of cosmology have focused on theory. But for every Sunyaev-Zel'dovich effect there is a Butcher-Oemler effect; there are as many cosmological phenomena established by observations, and only explained later by theory, as there were predicted by theory and confirmed by observations. In fact, in the last decade, there has been an explosion of new cosmological findings driven by observations. Some are so new that you won't find them mentioned in books just a few years old. So it is not just refreshing to see a book that reflects the new realities of cosmology, it is vital, if students are to truly stay up on a field that has widened in scope considerably. Observational Cosmology is filled with full-color images, and graphs from the latest experiments. How exciting it is that we live in an era where satellites and large experiments have gathered so much data to reveal astounding details about the origin of the universe and its evolution. To have all the latest data gathered together and explained in one book will be a revelation to students. In fact, at times it was to me. I've picked up modern cosmological knowledge through a patchwork of reading papers, going to colloquia, and serving on grant and telescope allocation panels. To go back and see them explained from square one, and summarized succinctly, filled in quite a few gaps in my own knowledge and corrected a few misconceptions I'd acquired along the way. To make room for all these graphs and observational details, a few things had to be left out. For one, there are few derivations

  5. Improvement of seismic observation systems in JOYO

    In the experimental fast reactor 'Joyo' in order to perform the seismic observation in and around the building block and ground, SMAC type seismographs had continuously been used for about 38 years. However, this equipment aged, and the 2011 off the Pacific Coast of Tohoku Earthquake on Mach 11, 2011 increased the importance of seismic data of the reactor facilities from the viewpoint of earthquake-proof safety. For these reasons, Joyo updated the system to the seismic observation system reflecting the latest technology/information, while keeping consistency with the observation data of the former seismographs (SMAC type seismograph). This updating improved various problems on the former observation seismographs. In addition, the installation of now observation points in the locations that are important in seismic safety evaluation expanded the data, and further improved the reliability of the seismic observation and evaluation on 'Joyo'. (A.O.)

  6. Deuteronation and aging.

    Olgun, Abdullah; Oztürk, Kamile; Bayir, Selda; Akman, Serif; Erbil, M Kemal


    Deuterium has one proton and one neutron in its atomic nucleus, but hydrogen has only proton. The natural abundance of deuterium is 1 per approximately 6600 hydrogen atoms. Therefore deuterated water (both HOD + D(2)O [heavy water]) abundance is 1 per approximately 3300 water molecules. One dissociation product of deuterated and heavy water is deuteron (proton + neutron, D(+), H(2)OD(+)/D(3)O(+)). Because heavy water has a lower ionization constant than water, the D(+)/H(+) ratio is approximately 1/15,000 in biological fluids. O-D bond length is shorter than O-H, and D-O-D angle is lesser than H-O-H. Once a deuteron exchanges with proton on the water-exposed surface of a macromolecule, it can lead to a conformational change and the reverse exchange will be less likely. Deuteron bonds are stronger than proton bonds. Therefore an increase of deuteronated macromolecules can be expected in due course of time. In order to test this hypothesis, we conducted a pilot study and measured the D/H ratio in the tails of three Sprague-Dawley rats at different ages (4 weeks, 5 weeks, and >1-year old) by elemental analysis coupled with isotope ratio mass spectrometry (EA-IRMS) technique. To prevent the effect of daily water consumption, the homogenized tails were lyophilized before analysis. The results, as mean of several measurements, of 4 weeks, 5 weeks, and >1-year-old rats were per thousand-94 +/- 9.56, per thousand-101.71 +/- 6.89, per thousand-83.68 +/- 3.46 delta((2)H) relative to VSMOW, respectively. Although there is a slight increase in >1-year-old rat, the difference among the animals was not significant. We propose that, before reaching to a final conclusion about the accumulation of deuterium with aging, the measurements should be done not in whole tissue samples but in purified macromolecules from a larger set of animals. PMID:17460204

  7. Gene expression-based biomarkers for Anopheles gambiae age grading.

    Wang, Mei-Hui; Marinotti, Osvaldo; Zhong, Daibin; James, Anthony A; Walker, Edward; Guda, Tom; Kweka, Eliningaya J; Githure, John; Yan, Guiyun


    Information on population age structure of mosquitoes under natural conditions is fundamental to the understanding of vectorial capacity and crucial for assessing the impact of vector control measures on malaria transmission. Transcriptional profiling has been proposed as a method for predicting mosquito age for Aedes and Anopheles mosquitoes, however, whether this new method is adequate for natural conditions is unknown. This study tests the applicability of transcriptional profiling for age-grading of Anopheles gambiae, the most important malaria vector in Africa. The transcript abundance of two An. gambiae genes, AGAP009551 and AGAP011615, was measured during aging under laboratory and field conditions in three mosquito strains. Age-dependent monotonic changes in transcript levels were observed in all strains evaluated. These genes were validated as age-grading biomarkers using the mark, release and recapture (MRR) method. The MRR method determined a good correspondence between actual and predicted age, and thus demonstrated the value of age classifications derived from the transcriptional profiling of these two genes. The technique was used to establish the age structure of mosquito populations from two malaria-endemic areas in western Kenya. The population age structure determined by the transcriptional profiling method was consistent with that based on mosquito parity. This study demonstrates that the transcription profiling method based on two genes is valuable for age determination of natural mosquitoes, providing a new approach for determining a key life history trait of malaria vectors. PMID:23936017

  8. Gene expression-based biomarkers for Anopheles gambiae age grading.

    Mei-Hui Wang

    Full Text Available Information on population age structure of mosquitoes under natural conditions is fundamental to the understanding of vectorial capacity and crucial for assessing the impact of vector control measures on malaria transmission. Transcriptional profiling has been proposed as a method for predicting mosquito age for Aedes and Anopheles mosquitoes, however, whether this new method is adequate for natural conditions is unknown. This study tests the applicability of transcriptional profiling for age-grading of Anopheles gambiae, the most important malaria vector in Africa. The transcript abundance of two An. gambiae genes, AGAP009551 and AGAP011615, was measured during aging under laboratory and field conditions in three mosquito strains. Age-dependent monotonic changes in transcript levels were observed in all strains evaluated. These genes were validated as age-grading biomarkers using the mark, release and recapture (MRR method. The MRR method determined a good correspondence between actual and predicted age, and thus demonstrated the value of age classifications derived from the transcriptional profiling of these two genes. The technique was used to establish the age structure of mosquito populations from two malaria-endemic areas in western Kenya. The population age structure determined by the transcriptional profiling method was consistent with that based on mosquito parity. This study demonstrates that the transcription profiling method based on two genes is valuable for age determination of natural mosquitoes, providing a new approach for determining a key life history trait of malaria vectors.

  9. Health screening - women - over age 65

    Health maintenance visit - women - over age 65; Physical exam - women - over age 65; Yearly exam - women - over age 65; Checkup - women - over age 65; Women's health - over age 65; Preventive care exam - women - over ...

  10. Health screening - men - ages 40 to 64

    Health maintenance visit - men - ages 40 to 64; Physical exam - men - ages 40 to 64; Yearly exam - ... 64; Checkup - men - ages 40 to 64; Men's health - ages 40 to 64; Preventive care - men - ages ...

  11. Health screening - women - ages 40 to 64

    Health maintenance visit - women - ages 40 to 64; Physical exam - women - ages 40 to 64; Yearly exam - ... 64; Checkup - women - ages 40 to 64; Women's health - ages 40 to 64; Preventive care - women - ages ...

  12. Health screening - women - ages 18 to 39

    Health maintenance visit - women - ages 18 to 39; Physical exam - women - ages 18 to 39; Yearly exam - ... 39; Checkup - women - ages 18 to 39; Women's health - ages 18 to 39; Preventive care - women - ages ...

  13. Health screening - men age 65 and older

    Health maintenance visit - men - over age 65; Physical exam - men - over age 65; Yearly exam - men - over age 65; Checkup - men - over age 65; Men's health - over age 65; Preventive care exam - men - over ...

  14. Optimal Aging and Death: Understanding the Preston Curve

    Dalgaard, Carl-Johan Lars; Strulik, Holger


    Does prosperity lead to greater longevity? If so, what is the strength of the income channel? To address these questions we develop a life cycle model in which households are subject to physiological aging. In modeling aging we draw on recent research in the fields of biology and medicine. The...... speed of the aging process, and thus the age of death, are endogenously determined by optimal health investments. A calibrated version of the model accounts well for the observed nonlinear cross-country link between longevity and income, also known as the Preston curve...

  15. The analysis of aging and elderly age quality in empirical research: data based on University of the Third Age (U3A) students.

    Zielińska-Więczkowska, Halina; Muszalik, Marta; Kędziora-Kornatowska, Kornelia


    The aim of the study was to evaluate aging and elderly age quality in elderly individuals and persons entering the elderly age participating U3A continuous education courses. The research included 255 students of the U3A located in Bydgoszcz, Poland. The research included 235 women and 20 men of mean age 64.43 years. The dominant group was persons with secondary education (65.9%), and higher education (28.2%) as well as married (54.5%). All of the subjects included in the study were fully mobile. The study was conducted based on authors' original questionnaire which consisted of 24 questions and a basic personal data form surveying age, gender, marital status, level of education as well as self-reported illnesses and health problems. The research assumed the majority of positive responses as the sign of happy aging and experiencing one's own old age. Positive correlation was observed between the statement that human beings influence quality and shape of their lives, and therefore they are responsible for their own life. The higher the level of fulfilling aims in life the more frequently elderly age was perceived as a happy period. In the research data there was a relationship observed between levels of education and discrimination, i.e., the higher level of education the fewer cases of discrimination experienced: χ(2)=12.992 (df=2; ppersons entering late adulthood period who attend continuous education courses at U3A. PMID:21962545

  16. Quantifying the shape of aging

    Wrycza, Tomasz F; Missov, Trifon I; Baudisch, Annette


    aging rates, suggest the shape of aging as a novel and valuable alternative concept for comparative aging research. The concept of shape captures the direction and degree of change in the force of mortality over age, which—on a demographic level—reflects aging. We 1) provide a list of shape properties...... that are desirable from a theoretical perspective, 2) suggest several demographically meaningful and non-parametric candidate measures to quantify shape, and 3) evaluate performance of these measures based on the list of properties as well as based on an illustrative analysis of a simple dataset. The...... shape measures suggested here aim to provide a general means to classify aging patterns independent of any particular mortality model and independent of any species-specific time-scale. Thereby they support systematic comparative aging research across different species or between populations of the same...

  17. Exercise and the Aging Endothelium

    Saeid Golbidi


    Full Text Available The endothelium plays a critical role in the maintenance of cardiovascular health by producing nitric oxide and other vasoactive materials. Aging is associated with a gradual decline in this functional aspect of endothelial regulation of cardiovascular homeostasis. Indeed, age is an independent risk factor for cardiovascular diseases and is in part an important factor in the increased exponential mortality rates from vascular disease such as myocardial infarction and stroke that occurs in the ageing population. There are a number of mechanisms suggested to explain age-related endothelial dysfunction. However, recent scientific studies have advanced the notion of oxidative stress and inflammation as the two major risk factors underlying aging and age-related diseases. Regular physical activity, known to have a favorable effect on cardiovascular health, can also improve the function of the ageing endothelium by modulating oxidative stress and inflammatory processes, as we discuss in this paper.

  18. Ages and Ages: The Multiplication of Children's "Ages" in Early Twentieth-Century Child Psychology

    Beauvais, Clementine


    This paper explores the trend, between 1905 and the late 1920s in UK and US child psychology, of "discovering," labelling and calculating different "ages" in children. Those new "ages"--from mental to emotional, social, anatomical ages, and more--were understood as either replacing, or meaningfully related to,…

  19. Age modifies the pituitary TSH response to thyroid failure

    Carlé, Allan; Laurberg, Peter; Pedersen, Inge B.; Perrild, Hans; Ovesen, Lars; Rasmussen, Lone Banke; Jorgensen, Torben; Knudsen, Nils


    Objective: To investigate the association between serum TSH, total T4 and various patient characteristics when hypothyroidism is diagnosed in a population, and to study how age, sex and serum T4 levels influenced pituitary TSH response. Design: A computer-based register linked to laboratory...... patients. No age dependent variation was observed in serum total T4. Log TSH showed an inverse linear correlation with age. An inverse linear correlation was present between log TSH and total T4 in both young and old patients, but for all total T4 values we observed lower median serum TSH values in elderly...

  20. Wisdom comes with age?


    ‘A relativistic generalization of the Navier-Stokes equations to quark-gluon plasmas’ – the work of a CERN physicist perhaps? No, actually it is the title of a high school student’s project! Thirteen of the world’s brightest young scientific minds were recently treated to a tour of CERN. The Bulletin finds out more. The Intel ISEF students during their visit to CERN.Thirteen science wunderkinds came to CERN for a three-day visit on 29 June. The high school students, aged between 16 and 18, were all winners of this year’s Intel International Science and Engineering Fair (Intel ISEF), the world’s largest pre-college science competition. As part of their prize they won a visit to CERN organized by the CERN openlab collaboration (see box). "The whole trip has been incredible, and this is my first time in Europe as well so that makes it even more exciting," said Ryan Alexander, just 16 years old, who won in the Energy and Tr...

  1. Aging and operation results

    The correlation between the different accelerated aging methods and operation reality has to be done with solid and representative elements in matter of tests as well as in operating experience. In 1990 in France, the first unit will be 13 years operating, there will be 34 units of 900 MW PWR and 18 units of 1300 MW PWR in operation. The total of experience will be equivalent to 400 reactor-years. Only computerised means permit to collect all corresponding events, to manage them and to draw a lot of conclusions. One describes these computerised applications explaining the different events collected, data input and interrogating possibilities. The first application, called ''events file'', records all important events in nuclear plants. For each of these events, an event reporting format is set up as soon as first informations are known and then is put into the file. An updating is performed when the event is better known and analyzed. Interrogating programs allow no specialist to access easily to this data bank. So it is possible to collect events of the same nature, of the same equipments or of the same systems. The second application called S.R.D.F. (fiability data bank system) collects all maintenance operations on certain mechanical and electrical equipment. These two computerized applications complete on another in the way they allow to do fiability and availability studies for some equipments or for some elements of a nuclear plant

  2. Ageing and water homeostasis

    Robertson, David; Jordan, Jens; Jacob, Giris; Ketch, Terry; Shannon, John R.; Biaggioni, Italo


    This review outlines current knowledge concerning fluid intake and volume homeostasis in ageing. The physiology of vasopressin is summarized. Studies have been carried out to determine orthostatic changes in plasma volume and to assess the effect of water ingestion in normal subjects, elderly subjects, and patients with dysautonomias. About 14% of plasma volume shifts out of the vasculature within 30 minutes of upright posture. Oral ingestion of water raises blood pressure in individuals with impaired autonomic reflexes and is an important source of noise in blood pressure trials in the elderly. On the average, oral ingestion of 16 ounces (473ml) of water raises blood pressure 11 mmHg in elderly normal subjects. In patients with autonomic impairment, such as multiple system atrophy, strikingly exaggerated pressor effects of water have been seen with blood pressure elevations greater than 75 mmHg not at all uncommon. Ingestion of water is a major determinant of blood pressure in the elderly population. Volume homeostasis is importantly affected by posture and large changes in plasma volume may occur within 30 minutes when upright posture is assumed.

  3. The Observer Strikes Back

    Hartle, James


    In the modern quantum mechanics of cosmology observers are physical systems within the universe. They have no preferred role in the formulation of the theory nor in its predictions of third person probabilities of what occurs. However, observers return to importance for the prediction of first person probabilities for what we observe of the universe: What is most probable to be observed is not necessarily what is most probable to occur. This essay reviews the basic framework for the computation of first person probabilities in quantum cosmology starting with an analysis of very simple models. It is shown that anthropic selection is automatic in this framework, because there is no probability for us to observe what is where we cannot exist. First person probabilities generally favor larger universes resulting from inflation where there are more places for us to be. In very large universes it is probable that our observational situation is duplicated elsewhere. The calculation of first person probabilities then...

  4. Does Observation Influence Learning?

    Olivier Armantier


    A common value auction experiment is run to compare the relative influence of observation and experience on learning. It is shown that the ex-post observation of opponents' actions and payoffs homogenizes behavior and accelerates learning toward the Nash equilibrium. Besides, experiential and observational learning are both relevant and of comparable magnitude. A general reinforcement model for continuous strategies, encompassing choice reinforcement learning, direction learning and payoff de...

  5. Observables on Quantum Structures

    Dvurečenskij, Anatolij; Kuková, Mária


    An observable on a quantum structure is any $\\sigma$-homomorphism of quantum structures from the Borel $\\sigma$-algebra into the quantum structure. We show that our partial information on an observable known only for all intervals of the form $(-\\infty,t)$ is sufficient to determine uniquely the whole observable defined on quantum structures like $\\sigma$-MV-algebras, $\\sigma$-effect algebras, Boolean $\\sigma$-algebras, monotone $\\sigma$-complete effect algebras with the Riesz Decomposition P...

  6. How observers create reality

    Josephson, Brian D


    Wheeler proposed that repeated acts of observation give rise to the reality that we observe, but offered no detailed mechanism for this. Here this creative process is accounted for on the basis of the idea that nature has a deep technological aspect that evolves as a result of selection processes that act upon observers making use of the technologies. This leads to the conclusion that our universe is the product of agencies that use these evolved technologies to suit particular purposes.

  7. Aging, rejuvenation and memory phenomena in spin glasses

    V Dupuis; F Bert; J-P Bouchaud; J Hammann; F Ladieu; D Parker; E Vincent


    In this paper, we review several important features of the out-of-equilibrium dynamics of spin glasses. Starting with the simplest experiments, we discuss the scaling laws used to describe the isothermal aging observed in spin glasses after a quench down to the low-temperature phase. We report in particular new results on the sub-aging behaviour of spin glasses. We then discuss the rejuvenation and memory effects observed when a spin glass is submitted to temperature variations during aging, from the point of view of both energy landscape pictures and real-space pictures. We highlight the fact that both approaches point out the necessity of hierarchical processes involved in aging. Finally, we report an investigation of the effect of small temperature variations on aging in spin glass samples with various anisotropies which indicates that this hierarchy depends on the spin anisotropy.

  8. Jupiter System Observer

    Senske, Dave; Kwok, Johnny


    This slide presentation reviews the proposed mission for the Jupiter System Observer. The presentation also includes overviews of the mission timeline, science goals, and spacecraftspecifications for the satellite.

  9. Automated Weather Observing System

    Department of Transportation — The Automated Weather Observing System (AWOS) is a suite of sensors, which measure, collect, and disseminate weather data to help meteorologists, pilots, and flight...

  10. Aerosol Observation System

    Oak Ridge National Laboratory — The aerosol observation system (AOS) is the primary Atmospheric Radiation Measurement (ARM) platform for in situ aerosol measurements at the surface. The principal...

  11. Active ageing and the unmaking of old age

    Lassen, Aske Juul

    -private innovation partnership (PPIP) that developed technologies catering to the active late life. A thorough analysis of active ageing entails studying what precisely active ageing tries to solve. I approach ageing as a matter of concern, a term proposed by Bruno Latour to describe how myriad practices and...... analysis of active ageing has changed throughout the project, I demonstrate how method, theory, and analysis intersect. Part 1 ends with my proposal of fibres as a tool to study matters of concern. In part 2, I dedicate a chapter to each of the three entangled formations. In chapter 5, I examine how...... article A, I describe how I participated in the innovation process of new technologies that cater to active ageing, and show how a specific kind of late life is assumed in such innovation processes. In article B, I portray active ageing as multiple knowledge-driven policy formats, which intend to unmake...

  12. Free radicals created by radiation and aging symptoms

    The universality of aging implies that its cause is basically the same in all species. A free radical hypothesis of aging has been proposed that the free radicals produced during normal metabolism of the cell over time damage DNA and other macromolecules leading to degenerative diseases, malignancies, and eventual death of vital cells which in turn causes aging and death of the organism. This hypothesis is supported by several observations. Radiation produces its biologic effect through free radical formation and causes premature aging. Second, the age pigment lipo fuscin is associated with lipid peroxidation. The hypothesis that oxygen radicals play a role in aging is also supported by the observation that, in general, long-lived species produce less endogenous free oxygen radicals because of their lower metabolic rate. Long-lived animals also have more superoxide dismutase than do their short-lived counterparts, and animal species with the longest lifespan have the highest levels of superoxide dismutase. Oxidative DNA damage is rapidly and effectively repaired. It has been estimated that there are several thousand oxidative DNA damage sites in a human cell every day, and the majority of these are repaired. However, a small fraction of unrepaired lesions could cause permanent changes in DNA and might be a major contributor to aging and cancer. A consequence of the free radical hypothesis of aging is the idea that free radical scavenging agents might be used to prevent aging. (author)

  13. PGC-1α in aging and anti-aging interventions

    Anderson, Rozalyn; Prolla, Tomas


    Deregulation of mitochondrial function is a common feature in multiple aspects of aging. In addition to playing a role in aging-associated disease, decline in mitochondrial energy metabolism is likely to be important in the development of metabolic disease. Furthermore, altered mitochondrial function is a conserved feature in caloric restriction – a dietary intervention that delays aging in diverse species. The transcriptional co-activator PGC-1α is a critical regulator of mitochondrial energ...

  14. "Is old age stigma? Ageing identity in Lithuania"

    Rapolienė, Grazina


    While population ageing is attracting ever more attention of international scientific community and social policy, its cultural and communicative aspects remain underinvestigated. The goal of the dissertation is to investigate the old age (ageing) identity in Lithuania, applying the sociological concept of stigma. In the pursuit of this goal, the research areas of stigma and ageism are connected, highlighting their common denominator - discrimination. The following questions are raised: wheth...

  15. Transgender, aging and old age - Do transgender people get old?

    Pedro Paulo Sammarco Antunes; Elisabeth Frohlich Mercadante


    This study is aimed to understand transgender aging context in Brazil. Normal and abnormal were especially created by biological sciences. For being considered deviants, transgender people are not seen as human beings. They end up living in violent environments. Their life expectancy is low. Many of them do not believe to reach old age. They face a lot of prejudice and death threat. Those who get to what we call old age are considered survivals. This investigation was able to show satisfactor...

  16. Turbulence Heating ObserveR - THOR

    Retino, Alessandro; Marcucci, Maria FedericaFederica; Vaivads, Andris; Escoubet, C. Philippe; Khotyaintsev, Yuri; Fazakerley, Andrew; Soucek, Jan; Gehler, Martin; Lavraud, Benoit; Vainio, Rami; Valentini, Francesco; Chen, Christopher H. K.; Narita, Yasuhito; Wielders, Arno


    Turbulent fluctuations are ubiquitous in astrophysical plasmas and reach up to scales as large as stars, bubbles or clouds blown out by stellar winds, or even entire galaxies. However, most of the irreversible energy dissipation produced by turbulent fluctuations occurs at very small scales, the so-called kinetic scales, where the plasma no longer behaves as a fluid and the properties of individual plasma species (electrons, protons, and other ions) become important. The heating of different plasma species as well as the acceleration of particles to high energies are governed by kinetic processes which determine how the turbulent electromagnetic fluctuations dissipate. Thus, processes at kinetic scales directly affect the large-scale properties of astrophysical plasmas. Turbulence Heating ObserveR (THOR) is the first mission ever flown in space fully dedicated to study plasma turbulent fluctuations and associated energization mechanisms. It will explore the kinetic plasma processes that determine the fundamental behavior of the majority of baryonic matter in the universe. THOR will lead to an understanding of the basic plasma heating and particle acceleration mechanisms, of their effect on different plasma species and of their relative importance in different turbulent regimes. THOR will provide closure of these fundamental questions by making detailed in situ measurements of the closest available dilute and turbulent magnetized plasmas at unprecedented temporal and spatial resolution. THOR focuses on particular regions in space: the pristine solar wind, the Earth's bow shock and interplanetary shocks, and the compressed solar wind regions downstream of shocks. These regions are selected because of their different turbulence properties, and reflect similar astrophysical environments. THOR is a candidate for selection as the next ESA M4 mission. Here we present THOR's science as well as the results of the ongoing mission study, currently undertaken at ESA.

  17. Age features of eyeball envelopes structure

    Ulyanova N.A.


    Full Text Available Background. The absence of adequate experimental model of myopia is the actual problem in pathophysiological investigation of the myopia progression. Studies of the chick eye have formed the basis for several hypotheses of myopia development. The most pathogenically valid animal model of myopia is a deprivation model. Before introduction of this model in mammals, in particular rats, it is necessary to investigate the dynamics of age morphological changes in sclera and retina. Objective. To determine the age-related features of the sclera and retina in intact rats. Methods. The sclera and retina were investigated by optic microscopy method on the 14th, 21st, 30th, 40th, 50th, 60th, 70th, 90th days after birth. Results. It was determined that sagittal, vertical and horizontal sizes of rats eyes increase more intensively at the age period from the 14th to the 30th day. At this time the maximal number of fibroblasts was observed in sclera. The total amount of these cells decreases after 40 days of postnatal ontogenesis. At the same time changes in thickness and compactness of retina layers were detected. At the age period from the 14th to the 30th day definitive scleral tissue architecture is not yet formed, part of collagen fibrils are organized in bundles, part of them are loosely arranged. On the 90th day all collagen fibrils of scleral stroma and retina are arranged. Conclusion. The highest intensity of sclera and retina restructuring is observed between the 14th and 30th days of postnatal ontogenesis. This period could be considered as optimal for experimental modeling of myopia in rats. Citation: Ulyanova NA. [Age features of eyeball envelopes structure]. Morphologia. 2014;8(1:95-8. Russian.

  18. A low molecular weight urinary proteome profile of human kidney aging

    Zürbig, Petra; Decramer, Stéphane; Dakna, Mohammed; Jantos, Justyna; Good, David M.; Coon, Joshua J.; Bandin, Flavio; Mischak, Harald; Bascands, Jean-Loup; Schanstra, Joost P


    Aging induces morphological changes of the kidney and reduces renal function. We analyzed the low molecular weight urinary proteome of 324 healthy individuals from 2-73 years of age to gain insight on renal aging in humans. We observed age-related modification of secretion of 325 out of 5000 urinary peptides. The majority of these changes was associated with renal development before and during puberty, while 49 peptides were related to aging in adults. Of these 49 peptides, the majority were ...

  19. Aging and functional brain networks

    Tomasi D.; Tomasi, D.; Volkow, N.D.


    Aging is associated with changes in human brain anatomy and function and cognitive decline. Recent studies suggest the aging decline of major functional connectivity hubs in the 'default-mode' network (DMN). Aging effects on other networks, however, are largely unknown. We hypothesized that aging would be associated with a decline of short- and long-range functional connectivity density (FCD) hubs in the DMN. To test this hypothesis, we evaluated resting-state data sets corresponding to 913 healthy subjects from a public magnetic resonance imaging database using functional connectivity density mapping (FCDM), a voxelwise and data-driven approach, together with parallel computing. Aging was associated with pronounced long-range FCD decreases in DMN and dorsal attention network (DAN) and with increases in somatosensory and subcortical networks. Aging effects in these networks were stronger for long-range than for short-range FCD and were also detected at the level of the main functional hubs. Females had higher short- and long-range FCD in DMN and lower FCD in the somatosensory network than males, but the gender by age interaction effects were not significant for any of the networks or hubs. These findings suggest that long-range connections may be more vulnerable to aging effects than short-range connections and that, in addition to the DMN, the DAN is also sensitive to aging effects, which could underlie the deterioration of attention processes that occurs with aging.

  20. Evolution of ageing since Darwin

    Michael R. Rose; Molly K. Burke; Parvin Shahrestani; Laurence D. Mueller


    In the late 19th century, the evolutionary approach to the problem of ageing was initiated by August Weismann, who argued that natural selection was more important for ageing than any physiological mechanism. In the mid-twentieth century, J. B. S. Haldane, P. B. Medawar and G. C. Williams informally argued that the force of natural selection falls with adult age. In 1966, W. D. Hamilton published formal equations that showed mathematically that two ‘forces of natural selection’ do indeed decline with age, though his analysis was not genetically explicit. Brian Charlesworth then developed the required mathematical population genetics for the evolution of ageing in the 1970’s. In the 1980’s, experiments using Drosophila showed that the rate of ageing evolves as predicted by Hamilton’s ‘forces of natural selection’. The discovery of the cessation of ageing late in life in the 1990’s was followed by its explanation in terms of evolutionary theory based on Hamilton’s forces. Recently, it has been shown that the cessation of ageing can also be manipulated experimentally using Hamilton’s ‘forces of natural selection’. Despite the success of evolutionary research on ageing, mainstream gerontological research has largely ignored both this work and the opportunity that it provides for effective intervention in ageing.